:- include('dir.header'). assertion_content_comment('tOboGo_LipidParticle',s("Any","particle","of","coalesced","lipids","in","the","cytoplasm","of","a","cell",".","May","include","associated","proteins","."),4074460). assertion_content_comment('tOboGo_LipidParticleTransportAlongMicrotubule',s("The","directed","movement","of","a","lipid","particle","along","a","microtubule",",","mediated","by","motor","proteins","."),4323713). assertion_content_comment('tOboGo_LipidPhosphataseActivity',s("Catalysis","of","the","reaction",":","a","phospholipid","+","H2O","=","a","lipid","+","phosphate","."),4206566). assertion_content_comment('tOboGo_LipidPhosphorylation',s("The","process","of","introducing","one","or","more","phosphate","groups","into","a","lipid",",","any","member","of","a","group","of","substances","soluble","in","lipid","solvents","but","only","sparingly","soluble","in","aqueous","solvents","."),4358077). assertion_content_comment('tOboGo_LipidStorage',s("The","accumulation","and","maintenance","in","cells","or","tissues","of","lipids",",","compounds","soluble","in","organic","solvents","but","insoluble","or","sparingly","soluble","in","aqueous","solvents",".","Lipid","reserves","can","be","accumulated","during","early","developmental","stages","for","mobilization","and","utilization","at","later","stages","of","development","."),4037364). assertion_content_comment('tOboGo_LipidTranslocation',s("The","translocation",",","or","flipping",",","of","lipid","molecules","from","one","monolayer","of","a","membrane","bilayer","to","the","opposite","monolayer","."),4135376). assertion_content_comment('tOboGo_LipidTransporterActivity',s("Enables","the","directed","movement","of","lipids","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4170121). assertion_content_comment('tOboGo_LipidTransportInvolvedInLipidStorage',s("The","directed","movement","of","lipids","into","cells","that","is","part","of","their","accumulation","and","maintenance","."),4037382). assertion_content_comment('tOboGo_LipidTransport',s("The","directed","movement","of","lipids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Lipids","are","compounds","soluble","in","an","organic","solvent","but","not",",","or","sparingly",",","in","an","aqueous","solvent","."),3993877). assertion_content_comment('tOboGo_LipidTubeAssemblyInvolvedInCytokinesis',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","macromolecules","to","form","a","macromolecular","complex","that","contains","a","tube","of","lipid","surrounded","by","a","protein","coat","involved","in","cytokinesis","."),4113174). assertion_content_comment('tOboGo_LipidTubeAssemblyInvolvedInOrganelleFission',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","macromolecules","to","form","a","macromolecular","complex","that","contains","a","tube","of","lipid","surrounded","by","a","protein","coat","involved","in","membrane","shaping","of","vesicle","membranes","as","organelles","undergo","fission","."),4113185). assertion_content_comment('tOboGo_LipidTubeAssemblyInvolvedInOrganelleFusion',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","macromolecules","to","form","a","macromolecular","complex","that","contains","a","tube","of","lipid","surrounded","by","a","protein","coat","involved","in","membrane","shaping","of","vesicle","membranes","as","organelles","fuse","."),4113196). assertion_content_comment('tOboGo_LipidTubeAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","macromolecules","to","form","a","macromolecular","complex","that","contains","a","tube","of","lipid","surrounded","by","a","protein","coat","involved","in","membrane","shaping","of","vesicle","membranes","as","the","fuse","or","undergo","fission","."),4113170). assertion_content_comment('tOboGo_LipidTube',s("A","macromolecular","complex","that","contains","a","tube","of","lipid","surrounded","by","a","protein","coat","."),4156739). assertion_content_comment('tOboGo_LipoamideBinding',s("Interacting","selectively","and","non-covalently","with","lipoamide",",","the","functional","form","of","lipoic","acid","in","which","the","carboxyl","group","is","attached","to","protein","by","an","amide","linkage","to","a","lysine","amino","group","."),4325549). assertion_content_comment('tOboGo_LipoamideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lipoamide",",","the","functional","form","of","lipoic","acid","in","which","the","carboxyl","group","is","attached","to","protein","by","an","amide","linkage","to","a","lysine","amino","group","."),4229092). assertion_content_comment('tOboGo_LipoarabinomannanBinding',s("Interacting","selectively","and","non-covalently","with","lipoarabinomannan","."),4384391). assertion_content_comment('tOboGo_LipoarabinomannanReceptorActivity',s("Combining","with","lipoarabinomannan","to","initiate","a","change","in","cell","activity","."),4384433). assertion_content_comment('tOboGo_LipoateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lipoate",",","1",",","2-dithiolane-3-pentanoate",",","the","anion","derived","from","lipoic","acid","."),4257766). assertion_content_comment('tOboGo_LipoateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lipoate","."),4333798). assertion_content_comment('tOboGo_LipoateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lipoate",",","1",",","2-dithiolane-3-pentanoate",",","the","anion","derived","from","lipoic","acid","."),4229086). assertion_content_comment('tOboGo_LipoateSynthaseActivity',s("Catalysis","of","the","reaction",":","protein","N6-","(","octanoyl",")","lysine","+","2","sulfur","+","2","S-adenosyl-L-methionine","=","protein","N6-","(","lipoyl",")","lysine","+","2","L-methionine","+","2","5","'","-deoxyadenosyl","."),4302333). assertion_content_comment('tOboGo_LipoicAcidBinding',s("Interacting","selectively","and","non-covalently","with","lipoic","acid",",","1",",","2-dithiolane-3-pentanoic","acid","."),4319526). assertion_content_comment('tOboGo_LipopeptideBinding',s("Interacting","selectively","and","non-covalently","with","a","lipopeptide",",","any","of","a","group","of","organic","compounds","comprising","two","or","more","amino","acids","linked","by","peptide","bonds","and","containing","a","nonprotein","group","consisting","of","a","lipid","or","lipids","."),4170060). assertion_content_comment('tOboGo_LipopeptideHormone',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4216998). assertion_content_comment('tOboGo_Lipophorin',s("OBSOLETE",".","Any","member","of","the","major","class","of","lipid-transporting","proteins","found","in","the","hemolymph","of","insects","."),4246379). assertion_content_comment('tOboGo_LipopolysaccharideBinding',s("Interacting","selectively","and","non-covalently","with","lipopolysaccharide","."),4361636). assertion_content_comment('tOboGo_LipopolysaccharideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lipopolysaccharides",",","any","of","a","group","of","related",",","structurally","complex","components","of","the","outer","membrane","of","Gram-negative","bacteria","."),4023926). assertion_content_comment('tOboGo_LipopolysaccharideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lipopolysaccharides",",","any","of","a","group","of","related",",","structurally","complex","components","of","the","outer","membrane","of","Gram-negative","bacteria","."),4257713). assertion_content_comment('tOboGo_LipopolysaccharideCoreHeptosyltransferaseActivity',s("Catalysis","of","the","reaction",":","glucosyl-heptosyl2-KDO2-lipid","A-phosphate","+","ADP-L-glycero-beta-D-manno-heptose","=","glucosyl-heptosyl3-KDO2-lipid","A-phosphate","+","ADP","+","H","+"),4168402). assertion_content_comment('tOboGo_LipopolysaccharideCoreRegionBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","core","region","of","bacterial","lipopolysaccharides",",","which","contains","ten","saccharide","residues","."),4023983). assertion_content_comment('tOboGo_LipopolysaccharideCoreRegionMetabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","core","region","of","bacterial","lipopolysaccharides",",","which","contains","ten","saccharide","residues",".","The","structure","of","this","core","oligosaccharide","appears","to","be","similar","in","closely","related","bacterial","strains","."),4023978). assertion_content_comment('tOboGo_LipopolysaccharideExporterActivity',s("Catalysis","of","the","transfer","of","lipopolysaccharide","from","the","inside","of","the","cell","to","the","outside","of","the","cell","across","a","membrane",".","A","lipopolysaccharide","is","any","of","a","group","of","related",",","structurally","complex","components","of","the","outer","membrane","of","Gram-negative","bacteria",".","Lipopolysaccharides","consist","three","covalently","linked","regions",",","lipid","A",",","core","oligosaccharide",",","and","an","O","side","chain",".","Lipid","A","is","responsible","for","the","toxicity","of","the","lipopolysaccharide","."),4290397). assertion_content_comment('tOboGo_LipopolysaccharideExport',s("The","directed","movement","of","lipopolysaccharides","out","of","a","cell","or","organelle","."),4294448). assertion_content_comment('tOboGo_LipopolysaccharideGlucosyltransferaseIActivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","lipopolysaccharide","=","UDP","+","D-glucosyl-lipopolysaccharide","."),4248703). assertion_content_comment('tOboGo_LipopolysaccharideGlucosyltransferaseIIActivity',s("Catalysis","of","the","reaction",":","lipopolysaccharide","+","UDP-D-glucose","=","D-glucosyl-lipopolysaccharide","+","UDP","."),4367525). assertion_content_comment('tOboGo_LipopolysaccharideHeptosyltransferaseActivity',s("Catalysis","of","the","reaction",":","a","lipopolysaccharide","+","ADP-L-glycero-beta-D-manno-heptose","=","a","heptosylated","lipopolysaccharide","+","ADP","+","H","+"),4168399). assertion_content_comment('tOboGo_LipopolysaccharideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lipopolysaccharides",",","any","of","a","group","of","related",",","structurally","complex","components","of","the","outer","membrane","of","Gram-negative","bacteria",".","Lipopolysaccharides","consist","three","covalently","linked","regions",",","lipid","A",",","core","oligosaccharide",",","and","an","O","side","chain",".","Lipid","A","is","responsible","for","the","toxicity","of","the","lipopolysaccharide","."),4023921). assertion_content_comment('tOboGo_LipopolysaccharideReceptorActivity',s("Combining","with","a","lipopolysaccharide","to","initiate","a","change","in","cell","activity",".","Lipopolysaccharides","(","LPS",")","are","major","components","of","the","outer","membrane","of","Gram-negative","bacteria",",","making","them","prime","targets","for","recognition","by","the","immune","system","."),4384402). assertion_content_comment('tOboGo_LipopolysaccharideReceptorComplex',s("A","multiprotein","complex","that","consists","of","at","least","three","proteins",",","CD14",",","TLR4",",","and","MD-2",",","each","of","which","is","glycosylated","."),4099222). assertion_content_comment('tOboGo_LipopolysaccharideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","lipopolysaccharides","from","one","side","of","the","membrane","to","the","other",".","A","lipopolysaccharide","is","any","of","a","group","of","related",",","structurally","complex","components","of","the","outer","membrane","of","Gram-negative","bacteria",".","Lipopolysaccharides","consist","three","covalently","linked","regions",",","lipid","A",",","core","oligosaccharide",",","and","an","O","side","chain",".","Lipid","A","is","responsible","for","the","toxicity","of","the","lipopolysaccharide","."),4290393). assertion_content_comment('tOboGo_LipopolysaccharideTransport',s("The","directed","movement","of","lipopolysaccharides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","A","lipopolysaccharide","is","any","of","a","group","of","related",",","structurally","complex","components","of","the","outer","membrane","of","Gram-negative","bacteria",".","Lipopolysaccharides","consist","three","covalently","linked","regions",",","lipid","A",",","core","oligosaccharide",",","and","an","O","side","chain",".","Lipid","A","is","responsible","for","the","toxicity","of","the","lipopolysaccharide","."),4294445). assertion_content_comment('tOboGo_LipoproteinAminoAcidOxidation',s("The","modification","of","a","lipoprotein","by","oxidation","of","one","or","more","amino","acids","in","the","protein","."),4357296). assertion_content_comment('tOboGo_LipoproteinAntitoxin',s("OBSOLETE",".","Binds","to","a","lipoprotein","toxin",",","which","is","usually","derived","from","a","microorganism",",","thereby","neutralizing","it","."),4290474). assertion_content_comment('tOboGo_LipoproteinBinding',s("OBSOLETE",".","Interacting","selectively","and","non-covalently","with","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids","."),4246951). assertion_content_comment('tOboGo_LipoproteinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids","."),4009703). assertion_content_comment('tOboGo_LipoproteinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids","."),4313456). assertion_content_comment('tOboGo_LipoproteinLipaseActivatorActivity',s("Increases","the","activity","of","a","lipoprotein","lipase",",","an","enzyme","that","catalyzes","of","the","hydrolysis","of","a","lipid","within","a","lipoprotein","."),4160057). assertion_content_comment('tOboGo_LipoproteinLipaseActivity',s("Catalysis","of","the","reaction",":","triacylglycerol","+","H2O","=","diacylglycerol","+","a","carboxylate","."),4205711). assertion_content_comment('tOboGo_LipoproteinLipidOxidation',s("The","modification","of","a","lipoprotein","by","oxidation","of","the","lipid","group","."),4116865). assertion_content_comment('tOboGo_LipoproteinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids","."),4009700). assertion_content_comment('tOboGo_LipoproteinModification',s("The","chemical","reactions","and","pathways","resulting","in","the","covalent","alteration","of","one","or","more","amino","acid","or","lipid","residues","occurring","in","a","lipoprotein",",","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids","."),4074856). assertion_content_comment('tOboGo_LipoproteinOxidation',s("The","modification","of","a","lipoprotein","by","oxidation","of","one","or","more","amino","acids","or","the","lipid","group","."),4074859). assertion_content_comment('tOboGo_LipoproteinParticleBinding',s("Interacting","selectively","and","non-covalently","with","a","lipoprotein","particle",".","A","lipoprotein","particle",",","also","known","as","a","lipoprotein",",","is","a","clathrate","complex","consisting","of","a","lipid","enwrapped","in","a","protein","host","without","covalent","binding","in","such","a","way","that","the","complex","has","a","hydrophilic","outer","surface","consisting","of","all","the","protein","and","the","polar","ends","of","any","phospholipids","."),4171100). assertion_content_comment('tOboGo_LipoproteinParticleMediatedSignaling',s("A","series","of","molecular","signals","mediated","by","the","detection","of","a","lipoprotein","particle","."),4109397). assertion_content_comment('tOboGo_LipoproteinParticleReceptorActivity',s("Combining","with","a","lipoprotein","particle","to","initiate","a","change","in","cell","activity",".","A","lipoprotein","particle",",","also","known","as","a","lipoprotein",",","is","a","clathrate","complex","consisting","of","a","lipid","enwrapped","in","a","protein","host","without","covalent","binding","in","such","a","way","that","the","complex","has","a","hydrophilic","outer","surface","consisting","of","all","the","protein","and","the","polar","ends","of","any","phospholipids","."),4174854). assertion_content_comment('tOboGo_LipoproteinParticleReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","lipoprotein","particle","receptor","."),4173014). assertion_content_comment('tOboGo_LipoproteinToxin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4290486). assertion_content_comment('tOboGo_LipoproteinTransporterActivity',s("Enables","the","directed","movement","of","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4316356). assertion_content_comment('tOboGo_LipoproteinTransport',s("The","directed","movement","of","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4316366). assertion_content_comment('tOboGo_LipoteichoicAcidBinding',s("Interacting","selectively","and","non-covalently","with","lipoteichoic","acid","."),4178361). assertion_content_comment('tOboGo_LipoteichoicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lipoteichoic","acid",",","which","is","a","major","component","of","the","cell","wall","of","gram-positive","bacteria","and","typically","consists","of","a","chain","of","glycerol-phosphate","repeating","units","linked","to","a","glycolipid","anchor","."),4173528). assertion_content_comment('tOboGo_LipoteichoicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lipoteichoic","acid",",","which","is","a","major","component","of","the","cell","wall","of","gram-positive","bacteria","and","typically","consists","of","a","chain","of","glycerol-phosphate","repeating","units","linked","to","a","glycolipid","anchor","."),4173664). assertion_content_comment('tOboGo_LipoteichoicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lipoteichoic","acid",",","which","is","a","major","component","of","the","cell","wall","of","gram-positive","bacteria","and","typically","consists","of","a","chain","of","glycerol-phosphate","repeating","units","linked","to","a","glycolipid","anchor","."),4173516). assertion_content_comment('tOboGo_LipoteichoicAcidReceptorActivity',s("Combining","with","lipoteichoic","acid","to","initiate","a","change","in","cell","activity","."),4178382). assertion_content_comment('tOboGo_LipoxygenaseActivity',s("Catalysis","of","the","reaction",":","linoleate","+","O2","=","(","9Z",",","11E",")","-","(","13S",")","-13-hydroperoxyoctadeca-9",",","11-dienoate","."),4304165). assertion_content_comment('tOboGo_LipoxygenasePathway',s("The","chemical","reactions","and","pathways","by","which","an","unsaturated","fatty","acid","(","such","as","arachidonic","acid","or","linolenic","acid",")","is","converted","to","other","compounds",",","and","in","which","the","first","step","is","hydroperoxide","formation","catalyzed","by","lipoxygenase","."),4239961). assertion_content_comment('tOboGo_LipoylOctanoylTransferaseActivity',s("Catalysis","of","the","reaction",":","octanoyl-","[","acyl-carrier","protein","]","+","protein","=","protein","N6-","(","octanoyl",")","lysine","+","acyl-carrier","protein","."),4342980). assertion_content_comment('tOboGo_LipoyltransferaseActivity',s("Catalysis","of","the","transfer","of","the","lipoyl","group","from","lipoyl-AMP","to","the","lysine","residue","of","lipoate-dependent","enzyme","."),4267409). assertion_content_comment('tOboGo_LiquidClearanceOpenTrachealSystem',s("The","clearance","of","liquid","from","the","epithelial","tubes","of","an","open","tracheal","system",",","shortly","before","the","emergence","of","the","larva",",","to","generate","an","air-filled","tubule","system","."),4072397). assertion_content_comment('tOboGo_Lithium_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Li","+","(","in",")","+","H","+","(","out",")","=","Li","+","(","out",")","+","H","+","(","in",")"),4331907). assertion_content_comment('tOboGo_LithiumIonBinding',s("Interacting","selectively","and","non-covalently","with","lithium","ions","(","Li","+",")"),4319536). assertion_content_comment('tOboGo_LithiumIonExport',s("The","directed","movement","of","lithium","ion","out","of","a","cell","or","organelle","."),4331946). assertion_content_comment('tOboGo_LithiumIonTransport',s("The","directed","movement","of","lithium","ion","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4331927). assertion_content_comment('tOboGo_LiverDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","liver","over","time",",","from","its","formation","to","the","mature","structure",".","The","liver","is","an","exocrine","gland","which","secretes","bile","and","functions","in","metabolism","of","protein","and","carbohydrate","and","fat",",","synthesizes","substances","involved","in","the","clotting","of","the","blood",",","synthesizes","vitamin","A",",","detoxifies","poisonous","substances",",","stores","glycogen",",","and","breaks","down","worn-out","erythrocytes","."),3986634). assertion_content_comment('tOboGo_LiverMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","liver","are","generated","and","organized","."),4125949). assertion_content_comment('tOboGo_LiverTrabeculaFormation',s("The","process","of","creating","a","trabecula","in","the","liver",".","A","trabecula","is","a","tissue","element","in","the","form","of","a","small","beam",",","strut","or","rod","."),4115292). assertion_content_comment('tOboGo_LobarBronchusDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","lobar","bronchus","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","lobar","bronchus","and","ends","with","the","mature","structure",".","The","lobar","bronchus","is","the","major","airway","within","the","respiratory","tree","that","starts","by","division","of","the","principal","bronchi","on","both","sides","and","ends","at","the","point","of","its","own","subdivision","into","tertiary","or","segmental","bronchi","."),4116517). assertion_content_comment('tOboGo_LobarBronchusEpitheliumDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","lobar","bronchus","epithelium","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","lobar","bronchus","epithelium","and","ends","with","the","mature","structure",".","The","lobar","bronchus","epithelium","is","the","tissue","made","up","of","epithelial","cells","that","lines","the","inside","of","the","lobar","bronchus","."),4116519). assertion_content_comment('tOboGo_LobarBronchusMesenchymeDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","lobar","bronchus","mesenchyme","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","lobar","bronchus","mesenchyme","and","ends","with","the","mature","structure",".","The","lobar","bronchus","mesenchyme","is","the","mass","of","tissue","composed","of","mesenchymal","cells","in","the","lobar","bronchus","."),4117593). assertion_content_comment('tOboGo_LocalizationOfCell',s("Any","process","in","which","a","cell","is","transported","to",",","and/or","maintained","in",",","a","specific","location","."),3985072). assertion_content_comment('tOboGo_Localization',s("Any","process","in","which","a","cell",",","a","substance",",","or","a","cellular","entity",",","such","as","a","protein","complex","or","organelle",",","is","transported","to",",","and/or","maintained","in","a","specific","location","."),3969970). assertion_content_comment('tOboGo_LocalizationWithinMembrane',s("Any","process","in","which","a","substance","or","cellular","entity",",","such","as","a","protein","complex","or","organelle",",","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","a","membrane","."),3986840). assertion_content_comment('tOboGo_LocomotionInvolvedInLocomotoryBehavior',s("Self-propelled","movement","of","a","cell","or","organism","from","one","location","to","another","in","a","behavioral","context",";","the","aspect","of","locomotory","behavior","having","to","do","with","movement","."),4058101). assertion_content_comment('tOboGo_Locomotion',s("Self-propelled","movement","of","a","cell","or","organism","from","one","location","to","another","."),3985061). assertion_content_comment('tOboGo_LocomotorRhythm',s("The","rhythm","of","the","locomotor","activity","of","an","organism","during","its","24","hour","activity","cycle","."),4299871). assertion_content_comment('tOboGo_LocomotoryBehavior',s("The","specific","movement","from","place","to","place","of","an","organism","in","response","to","external","or","internal","stimuli",".","Locomotion","of","a","whole","organism","in","a","manner","dependent","upon","some","combination","of","that","organism","'","s","internal","state","and","external","conditions","."),4058086). assertion_content_comment('tOboGo_LocomotoryExplorationBehavior',s("The","specific","movement","from","place","to","place","of","an","organism","in","response","to","a","novel","environment","."),4380007). assertion_content_comment('tOboGo_LocusCeruleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","locus","ceruleus","over","time",",","from","its","formation","to","the","mature","structure",".","The","locus","ceruleus","is","a","dense","cluster","of","neurons","within","the","dorsorostral","pons",".","This","nucleus","is","the","major","location","of","neurons","that","release","norepinephrine","throughout","the","brain",",","and","is","responsible","for","physiological","responses","to","stress","and","panic","."),4042876). assertion_content_comment('tOboGo_LocusCeruleusFormation',s("The","process","that","gives","rise","to","the","locus","ceruleus",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","In","mice",",","the","locus","ceruleus","is","a","dense","cluster","of","neurons","within","the","dorsorostral","pons",".","This","nucleus","is","the","major","location","of","neurons","that","release","norepinephrine","throughout","the","brain",",","and","is","responsible","for","physiological","responses","to","stress","and","panic","."),4042949). assertion_content_comment('tOboGo_LocusCeruleusMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","locus","ceruleus","to","attain","its","fully","functional","state",".","The","locus","ceruleus","is","a","dense","cluster","of","neurons","within","the","dorsorostral","pons",".","This","nucleus","is","the","major","location","of","neurons","that","release","norepinephrine","throughout","the","brain",",","and","is","responsible","for","physiological","responses","to","stress","and","panic","."),4043054). assertion_content_comment('tOboGo_LocusCeruleusMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","locus","ceruleus","is","generated","and","organized",".","In","mice",",","the","locus","ceruleus","is","a","dense","cluster","of","neurons","within","the","dorsorostral","pons",".","This","nucleus","is","the","major","location","of","neurons","that","release","norepinephrine","throughout","the","brain",",","and","is","responsible","for","physiological","responses","to","stress","and","panic","."),4042914). assertion_content_comment('tOboGo_LombricineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","lombricine","=","ADP","+","N-phospholombricine","."),4270769). assertion_content_comment('tOboGo_LongDescendingThinLimbBendDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","long","descending","thin","limb","bend","over","time",",","from","its","formation","to","the","mature","structure",".","The","long","descending","thin","limb","bend","is","a","part","of","the","descending","thin","limb","of","a","long","nephron","that","lies","beyond","the","prebend","segment","."),4123814). assertion_content_comment('tOboGo_LongDescendingThinLimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","long","descending","thin","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","long","descending","thin","limb","is","the","descending","thin","limb","of","a","long","nephron","that","has","a","squamous","epithelial","morphology",".","The","long","descending","limb","starts","in","the","inner","stripe","of","the","outer","medulla","and","extends","into","the","inner","medulla","."),4123804). assertion_content_comment('tOboGo_LongitudinalAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","longitudinal","axis",".","In","plants",",","this","is","the","axis","that","runs","from","the","shoot","to","the","root","."),4033336). assertion_content_comment('tOboGo_LongitudinalSarcoplasmicReticulumLumen',s("The","region","between","the","inner","and","outer","lipid","bilayers","of","the","longitudinal","sarcoplasmic","reticulum","envelope",".","The","longitudinal","sarcoplasmic","reticulum","lumen","is","continuous","with","the","lumen","contained","within","the","terminal","cisternae","."),4040168). assertion_content_comment('tOboGo_LongitudinalSarcoplasmicReticulum',s("The","portion","of","the","free","sarcoplasmic","reticulum","consisting","of","longitudinal","tubules","that","connect","terminal","cisternae","."),4040149). assertion_content_comment('tOboGo_LongitudinalSideOfCellSurface',s("The","side","of","the","cell","parallel","to","the","zygotic","axis","."),4021504). assertion_content_comment('tOboGo_LongNephronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","long","nephron","over","time",",","from","its","formation","to","the","mature","structure",".","Long","nephrons","are","associated","with","juxtamedullary","glomeruli","and","extend","into","the","inner","medulla","."),4123801). assertion_content_comment('tOboGo_LongTermSynapticDepression',s("A","process","that","modulates","synaptic","plasticity","such","that","synapses","are","changed","resulting","in","the","decrease","in","the","rate",",","or","frequency","of","synaptic","transmission","at","the","synapse","."),4159979). assertion_content_comment('tOboGo_LoopDNABinding',s("Interacting","selectively","and","non-covalently","with","DNA","containing","a","loop",".","A","loop","occurs","when","DNA","contains","a","large","insertion","or","deletion","that","causes","a","region","of","unpaired","single-stranded","DNA","to","loop","out",",","while","the","rest","of","the","DNA","is","in","a","paired","double-stranded","configuration","."),4362801). assertion_content_comment('tOboGo_LoopOfHenleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","loop","of","Henle","over","time",",","from","its","formation","to","the","mature","structure",".","The","loop","of","Henle","is","a","nephron","tubule","that","connects","the","proximal","convoluted","tubule","to","the","distal","convoluted","tubule","."),4123771). assertion_content_comment('tOboGo_LossOfAsymmetricBudding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236137). assertion_content_comment('tOboGo_LossOfChromatinSilencingInvolvedInReplicativeCellAging',s("The","process",",","which","occurs","as","a","dividing","cell","ages",",","leading","to","expression","of","genes","that","are","typically","not","expressed","due","to","silencing","by","regulatory","proteins","."),4362268). assertion_content_comment('tOboGo_LossOfChromatinSilencing',s("The","process","leading","to","expression","of","genes","that","are","typically","not","expressed","due","to","silencing","by","regulatory","proteins","."),4222580). assertion_content_comment('tOboGo_LovastatinNonaketideSynthaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","+","acetyl-CoA","+","18","H","(","+",")","+","8","malonyl-CoA","+","11","NADPH","=","S-adenosyl-L-homocysteine","+","8","CO","(","2",")","+","9","CoA","+","dihydromonacolin","L","+","6","H","(","2",")","O","+","11","NADP","(","+",")"),4277732). assertion_content_comment('tOboGo_LowAffinityFcReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4245569). assertion_content_comment('tOboGo_LowAffinityIgAReceptorActivity',s("Combining","with","low","affinity","with","an","immunoglobulin","of","an","IgA","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4375824). assertion_content_comment('tOboGo_LowAffinityIgEReceptorActivity',s("Combining","with","low","affinity","with","an","immunoglobulin","of","the","IgE","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4245534). assertion_content_comment('tOboGo_LowAffinityIgGReceptorActivity',s("Combining","with","low","affinity","with","an","immunoglobulin","of","an","IgG","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4245340). assertion_content_comment('tOboGo_LowAffinityIgMReceptorActivity',s("Combining","with","low","affinity","with","an","immunoglobulin","of","an","IgM","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4375755). assertion_content_comment('tOboGo_LowAffinityIronIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Fe2","+","(","out",")","=","Fe2","+","(","in",")"),4297507). assertion_content_comment('tOboGo_LowAffinityMetalIonUptakeTransporterActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","Me2","+","(","out",")","+","H","+","(","out",")","=","Me2","+","(","in",")","+","H","+","(","in",")","Me","can","be","Mn2","+","or","Cu2","+"),4296264). assertion_content_comment('tOboGo_LowAffinityNitrateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nitrate","ions","(","NO3-",")","from","one","side","of","a","membrane","to","the","other",".","In","low","affinity","transport","the","transporter","is","able","to","bind","the","solute","only","if","it","is","present","at","very","high","concentrations","."),4182671). assertion_content_comment('tOboGo_LowAffinityNitrateTransport',s("The","directed","movement","of","nitrate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","In","low","affinity","transport","the","transporter","is","able","to","bind","the","solute","only","if","it","is","present","at","very","high","concentrations","."),4182651). assertion_content_comment('tOboGo_LowAffinityPhosphateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","phosphate","from","one","side","of","the","membrane","to","the","other",".","In","low","affinity","transport","the","transporter","is","able","to","bind","the","solute","only","if","it","is","present","at","very","high","concentrations","."),4260876). assertion_content_comment('tOboGo_LowAffinitySecondaryActiveAmmoniumTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","ammonium","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport",".","In","low","affinity","transport","the","transporter","is","able","to","bind","the","solute","only","if","it","is","present","at","very","high","concentrations","."),4291684). assertion_content_comment('tOboGo_LowAffinitySodium_DicarboxylateSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","dicarboxylate","(","out",")","+","Na","+","(","out",")","=","dicarboxylate","(","in",")","+","Na","+","(","in",")","In","low","affinity","transport","the","transporter","is","able","to","bind","the","solute","only","if","it","is","present","at","very","high","concentrations","."),4295911). assertion_content_comment('tOboGo_LowAffinitySulfate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","sulfate","(","out",")","+","H","+","(","out",")","=","sulfate","(","in",")","+","H","+","(","in",")","In","low","affinity","transport","the","transporter","is","able","to","bind","the","solute","only","if","it","is","present","at","very","high","concentrations","."),4260916). assertion_content_comment('tOboGo_LowMolecularWeightKininogenBinding',s("Interacting","selectively","and","non-covalently","with","a","kininogen","of","low","molecular","mass","."),4307225). assertion_content_comment('tOboGo_LRRDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","LRR","domain","(","leucine","rich","repeats",")","of","a","protein","."),4311977). assertion_content_comment('tOboGo_Lsd12Complex',s("A","nucleosome-binding","protein","complex","that","comprises","two","SWIRM","domain","histone","demethylases","and","two","PHD","finger","proteins",".","The","complex","is","involved","in","transcriptional","regulation","via","heterochromatic","silencing","and","the","regulation","of","chromatin","boundary","formation",",","and","was","first","identified","in","fission","yeast","."),4347627). assertion_content_comment('tOboGo_LSURRNABinding',s("Interacting","selectively","and","non-covalently","with","the","large","ribosomal","subunit","RNA","(","LSU","rRNA",")",",","a","constituent","of","the","large","ribosomal","subunit",".","In","S",".","cerevisiae",",","this","is","the","25S","rRNA","."),4179288). assertion_content_comment('tOboGo_LUBACComplex',s("A","ubiquitin","ligase","complex","that","catalyzes","linear","head-to-tail","polyubiquitin","conjugation","on","its","targets",".","In","human","the","complex","consists","of","RBCK1",",","RNF31","and","SHARPIN",",","and","has","an","MW","of","approximately","600","kDa",",","suggesting","a","heteromultimeric","assembly","of","its","subunits",".","LUBAC","stands","for","Linear","Ubiquitin","Chain","Assembly","Complex","."),4169334). assertion_content_comment('tOboGo_LuciferinMonooxygenaseActivity',s("Catalysis","of","the","generalized","reaction",":","luciferin","+","O2","=","oxidized","luciferin","+","CO2","+","light",".","There","may","be","additional","substrates","and","reactants","involved","in","the","reaction",".","The","reaction","results","in","light","emission","as","luciferin","returns","to","the","ground","state","after","enzymatic","oxidation","."),4263711). assertion_content_comment('tOboGo_LugaroCellDifferentiation',s("The","process","in","which","neuroblasts","acquire","specialized","structural","and/or","functional","features","that","characterize","the","mature","Lugaro","cell",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","neuroblast","to","a","Lugaro","cell","fate",".","A","Lugaro","cell","is","an","inhibitory","GABAergic","interneuron","found","in","the","cerebellar","cortex","."),4043066). assertion_content_comment('tOboGo_LumenFormationOpenTrachealSystem',s("Creation","of","the","central","hole","of","a","tube","in","an","open","tracheal","system","through","which","gases","flow","."),4382137). assertion_content_comment('tOboGo_LuminalSurveillanceComplex',s("A","multiprotein","complex","that","recognizes","ERAD-luminal","misfolded","substrates","and","brings","them","to","the","ubiquitination/extraction","machinery",".","In","yeast",",","this","complex","consists","of","Yos9p",",","Kar2p","and","Hrd3p","proteins","."),4076577). assertion_content_comment('tOboGo_LungAlveolusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","alveolus","over","time",",","from","its","formation","to","the","mature","structure",".","The","alveolus","is","a","sac","for","holding","air","in","the","lungs",";","formed","by","the","terminal","dilation","of","air","passageways","."),4103767). assertion_content_comment('tOboGo_LungBasalCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells",",","e.g",".","embryonic","or","regenerative","cells",",","acquire","specialized","structural","and/or","functional","features","of","a","mature","basal","cell","found","in","the","lung",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate",".","A","basal","cell","is","an","epithelial","stem","cell","."),4116539). assertion_content_comment('tOboGo_LungCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells",",","e.g",".","embryonic","or","regenerative","cells",",","acquire","specialized","structural","and/or","functional","features","of","a","mature","cell","found","in","the","lung",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","."),4116535). assertion_content_comment('tOboGo_LungCiliatedCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","lung","ciliated","cell",".","A","lung","ciliated","cell","is","a","specialized","lung","epithelial","cell","that","contains","a","motile","cilium","for","moving","substances","released","from","lung","secretory","cells","."),4155990). assertion_content_comment('tOboGo_LungConnectiveTissueDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","lung","connective","tissue","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","lung","connective","tissue","and","ends","with","the","mature","structure",".","The","lung","connective","tissue","is","a","material","made","up","of","fibers","forming","a","framework","and","support","structure","for","the","lungs","."),4117220). assertion_content_comment('tOboGo_LungDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","lung","over","time",",","from","its","formation","to","the","mature","structure",".","In","all","air-breathing","vertebrates","the","lungs","are","developed","from","the","ventral","wall","of","the","oesophagus","as","a","pouch","which","divides","into","two","sacs",".","In","amphibians","and","many","reptiles","the","lungs","retain","very","nearly","this","primitive","sac-like","character",",","but","in","the","higher","forms","the","connection","with","the","esophagus","becomes","elongated","into","the","windpipe","and","the","inner","walls","of","the","sacs","become","more","and","more","divided",",","until",",","in","the","mammals",",","the","air","spaces","become","minutely","divided","into","tubes","ending","in","small","air","cells",",","in","the","walls","of","which","the","blood","circulates","in","a","fine","network","of","capillaries",".","In","mammals","the","lungs","are","more","or","less","divided","into","lobes",",","and","each","lung","occupies","a","separate","cavity","in","the","thorax","."),4048317). assertion_content_comment('tOboGo_LungEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","epithelial","cell","that","contributes","to","the","epithelium","of","the","lung","."),4117528). assertion_content_comment('tOboGo_LungEpitheliumDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","the","lung","epithelium","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","lung","epithelium","and","ends","with","the","mature","structure",".","The","lung","epithelium","is","the","specialized","epithelium","that","lines","the","inside","of","the","lung","."),4116506). assertion_content_comment('tOboGo_LungFieldSpecification',s("The","process","that","results","in","the","delineation","of","a","specific","region","of","the","foregut","into","the","area","in","which","the","lung","will","develop","."),4116634). assertion_content_comment('tOboGo_LungGobletCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","lung","goblet","cell",".","A","goblet","cell","is","a","cell","of","the","epithelial","lining","that","produces","and","secretes","mucins","."),4117532). assertion_content_comment('tOboGo_LungGrowth',s("The","increase","in","size","or","mass","of","a","lung",".","In","all","air-breathing","vertebrates","the","lungs","are","developed","from","the","ventral","wall","of","the","oesophagus","as","a","pouch","which","divides","into","two","sacs",".","In","amphibians","and","many","reptiles","the","lungs","retain","very","nearly","this","primitive","sac-like","character",",","but","in","the","higher","forms","the","connection","with","the","esophagus","becomes","elongated","into","the","windpipe","and","the","inner","walls","of","the","sacs","become","more","and","more","divided",",","until",",","in","the","mammals",",","the","air","spaces","become","minutely","divided","into","tubes","ending","in","small","air","cells",",","in","the","walls","of","which","the","blood","circulates","in","a","fine","network","of","capillaries",".","In","mammals","the","lungs","are","more","or","less","divided","into","lobes",",","and","each","lung","occupies","a","separate","cavity","in","the","thorax","."),4113279). assertion_content_comment('tOboGo_LungInduction',s("The","close","range","interaction","of","two","or","more","cells","or","tissues","that","causes","the","cells","of","the","foregut","to","change","their","fates","and","specify","the","development","of","the","lung","."),4116637). assertion_content_comment('tOboGo_LungLobeDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","lung","lobe","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","a","lung","lobe","by","branching","morphogenesis","and","ends","with","the","mature","structure",".","A","lung","lobe","is","one","of","the","rounded","projections","that","compose","the","lung","."),4117765). assertion_content_comment('tOboGo_LungLobeFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","lung","lobe","from","unspecified","parts",".","This","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","lobe","and","ends","when","the","structural","rudiment","is","recognizable",".","A","lung","lobe","is","a","projection","that","extends","from","the","lung","."),4117852). assertion_content_comment('tOboGo_LungLobeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","lung","lobe","are","generated","and","organized",".","A","lung","lobe","is","a","projection","that","extends","from","the","lung","."),4117842). assertion_content_comment('tOboGo_LungMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","lung","are","generated","and","organized","."),4113488). assertion_content_comment('tOboGo_LungNeuroendocrineCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuroendocrine","cell","of","the","lung","epithelium","."),4155971). assertion_content_comment('tOboGo_LungPatternSpecificationProcess',s("Any","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","lung",",","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4117263). assertion_content_comment('tOboGo_LungProximalDistalAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","proximal/distal","axis","of","the","lung",".","The","proximal/distal","axis","of","the","lung","is","defined","by","a","line","that","runs","from","the","trachea","to","the","alveoli","."),4156146). assertion_content_comment('tOboGo_LungSacculeDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","lung","saccule","from","an","initial","condition","to","its","mature","state",".","The","lung","saccule","is","the","primitive","gas","exchange","portion","of","the","lung","composed","of","type","I","and","type","II","cells","."),4117242). assertion_content_comment('tOboGo_LungSecretoryCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","lung","secretory","cell",".","A","lung","secretory","cell","is","a","specialized","epithelial","cell","of","the","lung","that","contains","large","secretory","granules","in","its","apical","part","."),4155999). assertion_content_comment('tOboGo_LungSmoothMuscleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","smooth","muscle","in","the","lung","over","time",",","from","its","formation","to","the","mature","structure","."),4135638). assertion_content_comment('tOboGo_LungVasculatureDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","lung","vasculature","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","lung","vasculature","and","ends","with","the","mature","structure",".","The","lung","vasculature","is","composed","of","the","tubule","structures","that","carry","blood","or","lymph","in","the","lungs","."),4117231). assertion_content_comment('tOboGo_LupeolSynthaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2",",","3-epoxysqualene","=","lupeol",".","This","reaction","is","the","cyclization","of","(","S",")","-2",",","3-epoxysqualene","(","2",",","3-oxidosqualene",")","to","lupeol","."),4314094). assertion_content_comment('tOboGo_Luteinization',s("The","set","of","processes","resulting","in","differentiation","of","theca","and","granulosa","cells","into","luteal","cells","and","in","the","formation","of","a","corpus","luteum","after","ovulation","."),3981191). assertion_content_comment('tOboGo_LuteinizingHormoneReceptorActivity',s("Combining","with","luteinizing","hormone","(","also","called","lutropin",")","to","initiate","a","change","in","cell","activity","."),4198168). assertion_content_comment('tOboGo_LuteinizingHormoneSecretion',s("The","regulated","release","of","luteinizing","hormone",",","a","gonadotropic","glycoprotein","hormone","secreted","by","the","anterior","pituitary","."),4062998). assertion_content_comment('tOboGo_LuteinizingHormoneSignalingPathwayInvolvedInOvarianFollicleDevelopment',s("The","series","of","molecular","signals","initiated","by","luteinizing","hormone","binding","to","a","receptor",",","where","the","activated","receptor","signals","via","downstream","effectors","that","contribute","to","progression","of","the","ovarian","follicle","over","time",",","from","its","formation","to","the","mature","structure","."),4084497). assertion_content_comment('tOboGo_LuteinizingHormoneSignalingPathway',s("The","series","of","molecular","signals","mediated","by","luteinizing","hormone","."),4084492). assertion_content_comment('tOboGo_LuteolinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","luteolin",",","2-","(","3",",","4-dihydroxyphenyl",")","-5",",","7-dihydroxy-4H-chromen-4-one","."),4340588). assertion_content_comment('tOboGo_LuteolinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","luteolin",",","2-","(","3",",","4-dihydroxyphenyl",")","-5",",","7-dihydroxy-4H-chromen-4-one","."),4340584). assertion_content_comment('tOboGo_Luteolysis',s("The","lysis","or","structural","demise","of","the","corpus","luteum",".","During","normal","luteolysis",",","two","closely","related","events","occur",".","First",",","there","is","loss","of","the","capacity","to","synthesize","and","secrete","progesterone","(","functional","luteolysis",")","followed","by","loss","of","the","cells","that","comprise","the","corpus","luteum","(","structural","luteolysis",")","Preventing","luteolysis","is","crucial","to","maintain","pregnancy","."),3981147). assertion_content_comment('tOboGo_LyaseActivity',s("Catalysis","of","the","cleavage","of","C-C",",","C-O",",","C-N","and","other","bonds","by","other","means","than","by","hydrolysis","or","oxidation",",","or","conversely","adding","a","group","to","a","double","bond",".","They","differ","from","other","enzymes","in","that","two","substrates","are","involved","in","one","reaction","direction",",","but","only","one","in","the","other","direction",".","When","acting","on","the","single","substrate",",","a","molecule","is","eliminated","and","this","generates","either","a","new","double","bond","or","a","new","ring","."),4073955). assertion_content_comment('tOboGo_LycopeneBetaCyclaseActivity',s("Catalysis","of","the","cyclization","of","beta","rings","at","one","or","both","ends","of","the","lycopene","molecule","(","psi",",","psi-carotene",")","to","form","gamma-carotene","or","the","bicyclic","beta-carotene","(","beta",",","beta-carotene",")",",","respectively","."),4299613). assertion_content_comment('tOboGo_LycopeneEpsilonCyclaseActivity',s("Catalysis","of","the","cyclization","of","an","epsilon","ring","at","one","end","of","the","lycopene","molecule","(","psi",",","psi-carotene",")","to","form","delta-carotene","(","epsilon",",","psi-carotene",")"),4299601). assertion_content_comment('tOboGo_Lymphangiogenesis',s("Lymph","vessel","formation","when","new","vessels","emerge","from","the","proliferation","of","pre-existing","vessels","."),3988401). assertion_content_comment('tOboGo_LymphaticEndothelialCellDifferentiation',s("The","process","in","which","a","venous","blood","vessel","endothelial","cell","acquires","specialized","features","of","a","lymphatic","vessel","endothelial","cell",",","a","thin","flattened","cell","that","lines","the","inside","surfaces","of","lymph","vessels","."),4113679). assertion_content_comment('tOboGo_LymphaticEndothelialCellFateCommitment',s("The","commitment","of","a","venous","blood","vessel","endothelial","cell","to","a","lymphatic","endothelial","cell","fate","and","its","capacity","to","differentiate","into","a","lymphatic","endothelial","cell","."),4113744). assertion_content_comment('tOboGo_LymphCirculation',s("The","flow","of","lymph","through","the","body","of","an","animal","."),4193896). assertion_content_comment('tOboGo_LymphGlandCrystalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","larval","lymph","gland-derived","hemocyte","precursor","cell","acquires","the","specialized","features","of","a","crystal","cell",".","Crystal","cells","are","a","class","of","cells","that","contain","crystalline","inclusions","and","are","involved","in","the","melanization","of","pathogenic","material","in","the","hemolymph","."),4382075). assertion_content_comment('tOboGo_LymphGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","lymph","gland","over","time",",","from","its","formation","to","the","mature","structure",".","The","lymph","gland","is","one","of","the","sites","of","hemocyte","differentiation",".","It","consists","of","three","to","six","bilaterally","paired","lobes","that","are","attached","to","the","cardioblasts","during","larval","stages",",","and","it","degenerates","during","pupal","stages","."),4072059). assertion_content_comment('tOboGo_LymphGlandPlasmatocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","larval","lymph","gland-derived","hemocyte","precursor","cell","acquires","the","specialized","features","of","the","phagocytic","blood-cell","type",",","the","plasmatocyte","."),4382085). assertion_content_comment('tOboGo_LymphNodeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","lymph","nodes","over","time",",","from","their","formation","to","the","mature","structure",".","A","lymph","node","is","a","round",",","oval",",","or","bean","shaped","structure","localized","in","clusters","along","the","lymphatic","vessels",",","with","a","distinct","internal","structure","including","specialized","vasculature","and","B-","and","T-zones","for","the","activation","of","lymphocytes","."),4234483). assertion_content_comment('tOboGo_LymphocyteActivationInvolvedInImmuneResponse',s("A","change","in","morphology","and","behavior","of","a","lymphocyte","resulting","from","exposure","to","a","specific","antigen",",","mitogen",",","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),3992423). assertion_content_comment('tOboGo_LymphocyteActivation',s("A","change","in","morphology","and","behavior","of","a","lymphocyte","resulting","from","exposure","to","a","specific","antigen",",","mitogen",",","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),3984564). assertion_content_comment('tOboGo_LymphocyteAggregation',s("The","adhesion","of","one","lymphocyte","to","one","or","more","other","lymphocytes","via","adhesion","molecules","."),4142630). assertion_content_comment('tOboGo_LymphocyteAnergy',s("Any","process","contributing","to","lymphocyte","anergy",",","a","state","of","functional","inactivation","."),3993816). assertion_content_comment('tOboGo_LymphocyteAntigen',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218244). assertion_content_comment('tOboGo_LymphocyteApoptosis',s("The","process","of","apoptosis","in","a","lymphocyte","."),3993760). assertion_content_comment('tOboGo_LymphocyteChemotaxisAcrossHighEndothelialVenule',s("The","movement","of","a","lymphocyte","to","cross","a","high","endothelial","venule","in","response","to","an","external","stimulus","."),4381172). assertion_content_comment('tOboGo_LymphocyteChemotaxis',s("The","directed","movement","of","a","lymphocyte","in","response","to","an","external","stimulus","."),4026031). assertion_content_comment('tOboGo_LymphocyteCostimulation',s("The","process","of","providing",",","via","surface-bound","receptor-ligand","pairs",",","a","second",",","antigen-independent",",","signal","in","addition","to","that","provided","by","the","B-","or","T","cell","receptor","to","augment","B-","or","T","cell","activation","."),4144701). assertion_content_comment('tOboGo_LymphocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","precursor","cell","acquires","specialized","features","of","a","lymphocyte",".","A","lymphocyte","is","a","leukocyte","commonly","found","in","the","blood","and","lymph","that","has","the","characteristics","of","a","large","nucleus",",","a","neutral","staining","cytoplasm",",","and","prominent","heterochromatin","."),3988996). assertion_content_comment('tOboGo_LymphocyteHomeostasis',s("The","process","of","regulating","the","proliferation","and","elimination","of","lymphocytes","such","that","the","total","number","of","lymphocytes","within","a","whole","or","part","of","an","organism","is","stable","over","time","in","the","absence","of","an","outside","stimulus","."),3984802). assertion_content_comment('tOboGo_LymphocyteMediatedImmunity',s("Any","process","involved","in","the","carrying","out","of","an","immune","response","by","a","lymphocyte","."),3982944). assertion_content_comment('tOboGo_LymphocyteMigrationIntoLymphNode',s("The","movement","of","a","lymphocyte","within","the","lymphatic","system","into","a","lymph","node",",","and","its","subsequent","positioning","within","defined","functional","compartments","such","as","sites","of","cell","activation","by","antigen","."),4074037). assertion_content_comment('tOboGo_LymphocyteMigrationIntoLymphoidOrgans',s("The","movement","of","a","lymphocyte","within","the","lymphatic","system","into","lymphoid","organs","such","as","lymph","nodes",",","spleen","or","Peyer","'","s","patches",",","and","its","subsequent","positioning","within","defined","functional","compartments","such","as","sites","of","cell","activation","by","antigen","."),4074034). assertion_content_comment('tOboGo_LymphocyteMigration',s("The","movement","of","a","lymphocyte","within","or","between","different","tissues","and","organs","of","the","body","."),4026029). assertion_content_comment('tOboGo_LymphocyteProliferation',s("The","expansion","of","a","lymphocyte","population","by","cell","division","."),3984852). assertion_content_comment('tOboGo_LymphoidProgenitorCellDifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","lymphoid","progenitor","cell",".","Lymphoid","progenitor","cells","include","progenitor","cells","for","any","of","the","lymphoid","lineages","."),3996197). assertion_content_comment('tOboGo_LymphotoxinABiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","cytokine","lymphotoxin","A","."),4079718). assertion_content_comment('tOboGo_LymphotoxinAProduction',s("The","appearance","of","lymphotoxin","A","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4068337). assertion_content_comment('tOboGo_LymphVesselDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","lymph","vessel","over","time",",","from","its","formation","to","the","mature","structure","."),3988391). assertion_content_comment('tOboGo_LysinActivity',s("OBSOLETE",".","An","agent","that","can","lyse","cells","."),4291832). assertion_content_comment('tOboGo_LysineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lysine",",","2",",","6-diaminohexanoic","acid","."),4042266). assertion_content_comment('tOboGo_LysineBiosyntheticProcessViaAminoadipicAcid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lysine","by","the","aminoadipic","pathway","."),4183672). assertion_content_comment('tOboGo_LysineBiosyntheticProcessViaDiaminopimelateDehydrogenasePathway',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lysine",",","via","the","intermediate","diaminopimelate",";","in","this","pathway","tetrahydrodipicolinate","is","converted","to","meso-diaminopimelate","in","a","single","enzymatic","step","."),4338831). assertion_content_comment('tOboGo_LysineBiosyntheticProcessViaDiaminopimelate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lysine",",","via","the","intermediate","diaminopimelate","."),4042298). assertion_content_comment('tOboGo_Lysine_CadaverineAntiporterActivity',s("Catalysis","of","the","reaction",":","lysine","(","out",")","+","cadaverine","(","in",")","=","lysine","(","in",")","+","cadaverine","(","out",")"),4326619). assertion_content_comment('tOboGo_LysineCarbamoyltransferaseActivity',s("Catalysis","of","the","reaction",":","L-lysine","+","carbamoyl","phosphate","=","L-homocitrulline","+","H","(","+",")","+","phosphate","."),4270916). assertion_content_comment('tOboGo_LysineCarboxypeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","peptidyl-L-lysine","(","or","peptidyl-L-arginine",")","+","H2O","=","peptide","+","L-lysine","(","or","L-arginine",")","Release","of","a","C-terminal","basic","amino","acid",",","preferentially","lysine",";","inactivates","bradykinin","and","anaphylatoxins","in","blood","plasma","."),4210588). assertion_content_comment('tOboGo_LysineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lysine",",","2",",","6-diaminohexanoic","acid","."),4231555). assertion_content_comment('tOboGo_LysineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","L-lysine","+","H","(","+",")","=","cadaverine","+","CO","(","2",")"),4248603). assertion_content_comment('tOboGo_LysineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-lysine","+","NAD","+","=","1",",","2-didehydropiperidine-2-carboxylate","+","NH3","+","NADH","."),4270927). assertion_content_comment('tOboGo_Lysine_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","lysine","(","out",")","+","H","+","(","out",")","=","lysine","(","in",")","+","H","+","(","in",")"),4292316). assertion_content_comment('tOboGo_LysineImport',s("The","directed","movement","of","lysine",",","2",",","6-diaminohexanoic","acid",",","into","a","cell","or","organelle","."),4025877). assertion_content_comment('tOboGo_LysineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lysine",",","2",",","6-diaminohexanoic","acid","."),4042230). assertion_content_comment('tOboGo_LysineRacemaseActivity',s("Catalysis","of","the","reaction",":","L-lysine","=","D-lysine","."),4285076). assertion_content_comment('tOboGo_LysineTransport',s("The","directed","movement","of","lysine",",","2",",","6-diaminohexanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4025862). assertion_content_comment('tOboGo_Lysogeny',s("The","incorporation","of","a","bacteriophage","genome","into","the","genome","of","its","bacterial","host","organism","."),4045134). assertion_content_comment('tOboGo_LysolecithinAcylmutaseActivity',s("Catalysis","of","the","reaction",":","1-acyl-sn-glycero-3-phosphocholine","=","2-acyl-sn-glycero-3-phosphocholine","."),4271043). assertion_content_comment('tOboGo_LysophosphatidicAcidAcyltransferaseActivity',s("Catalysis","of","the","transfer","of","acyl","groups","from","an","acyl-CoA","to","lysophosphatidic","acid","to","form","phosphatidic","acid","."),4313429). assertion_content_comment('tOboGo_LysophosphatidicAcidBinding',s("Interacting","selectively","and","non-covalently","with","lysophosphatidic","acid","(","LPA",")",",","a","phospholipid","derivative","that","acts","as","a","potent","mitogen","due","to","its","activation","of","high-affinity","G-protein-coupled","receptors","."),4380804). assertion_content_comment('tOboGo_LysophosphatidicAcidPhosphataseActivity',s("Catalysis","of","the","reaction",":","lysophosphatidic","acid","+","H2O","=","phosphate","+","monoacylglycerol","."),4191739). assertion_content_comment('tOboGo_LysophosphatidicAcidReceptorActivity',s("Combining","with","lysophosphatidic","acid","to","initiate","a","change","in","cell","activity","."),4178257). assertion_content_comment('tOboGo_LysophosphatidylethanolamineAcyltransferaseActivity',s("Catalysis","of","the","transfer","of","acyl","groups","from","an","acyl-CoA","to","lysophosphatidylethanolamine","."),4172667). assertion_content_comment('tOboGo_LysophospholipaseActivity',s("Catalysis","of","the","reaction",":","2-lysophosphatidylcholine","+","H2O","=","glycerophosphocholine","+","a","carboxylate","."),4203032). assertion_content_comment('tOboGo_LysophospholipidAcyltransferaseActivity',s("Catalysis","of","the","transfer","of","acyl","groups","from","an","acyl-CoA","to","a","lysophospholipid","."),4172665). assertion_content_comment('tOboGo_LysophospholipidTransporterActivity',s("Enables","the","directed","movement","of","lysophospholipids","into",",","out","of","or","within","a","cell",",","or","between","cells",".","A","lysophospholipid","is","a","phospholipid","that","lacks","one","of","its","fatty","acyl","chains",";","it","is","an","intermediate","formed","during","digestion","of","dietary","and","biliary","phospholipids","."),4183715). assertion_content_comment('tOboGo_LysophospholipidTransport',s("The","directed","movement","of","phospholipids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","A","lysophospholipid","is","a","phospholipid","that","lacks","one","of","its","fatty","acyl","chains",";","it","is","an","intermediate","formed","during","digestion","of","dietary","and","biliary","phospholipids","."),4183724). assertion_content_comment('tOboGo_LysosomalEnzymeProductionInvolvedInInflammatoryResponse',s("The","synthesis","or","release","of","lysosomal","enzymes","following","a","stimulus","as","part","of","a","inflammatory","response",",","resulting","in","an","increase","in","intracellular","or","extracellular","levels","."),3995885). assertion_content_comment('tOboGo_LysosomalEnzymeSecretionInvolvedInInflammatoryResponse',s("The","regulated","release","of","lysosomal","enzymes","by","a","cell","or","group","of","cells","as","part","of","an","inflammatory","response","."),3995907). assertion_content_comment('tOboGo_LysosomalGlycocalyx',s("The","polysaccharide-based","coating","on","the","inner","side","of","a","lysosomal","membrane","that","protects","it","from","digestion","by","lysosomal","enzymes","."),4149037). assertion_content_comment('tOboGo_LysosomalLumenAcidification',s("Any","process","that","reduces","the","pH","of","the","lysosomal","lumen",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4235357). assertion_content_comment('tOboGo_LysosomalLumenPHElevation',s("Any","process","that","increases","the","pH","of","the","lysosomal","lumen",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4381255). assertion_content_comment('tOboGo_LysosomalLumen',s("The","volume","enclosed","within","the","lysosomal","membrane","."),4092888). assertion_content_comment('tOboGo_LysosomalMembrane',s("The","lipid","bilayer","surrounding","the","lysosome","and","separating","its","contents","from","the","cell","cytoplasm","."),4007720). assertion_content_comment('tOboGo_LysosomalMultienzymeComplex',s("A","protein","complex","found","in","the","lysosome","that","contains","beta-galactosidase",",","cathepsin","A",",","alpha-neuraminidase","and","N-acetylgalactosamine-6-sulfate","sulfatase",",","and","is","involved","in","glycosaminoglycan","catabolism","."),4131068). assertion_content_comment('tOboGo_LysosomalProteinStabilization',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4268818). assertion_content_comment('tOboGo_LysosomalTransport',s("The","directed","movement","of","substances","into",",","out","of","or","within","a","lysosome","."),4034735). assertion_content_comment('tOboGo_LysosomeLocalization',s("Any","process","in","which","a","lysosome","is","transported","to",",","and/or","maintained","in",",","a","specific","location","."),4335055). assertion_content_comment('tOboGo_LysosomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","lysosome",".","A","lysosome","is","a","cytoplasmic",",","membrane-bounded","organelle","that","is","found","in","most","animal","cells","and","that","contains","a","variety","of","hydrolases","."),4081441). assertion_content_comment('tOboGo_Lysosome',s("A","small","lytic","vacuole","that","has","cell","cycle-independent","morphology","and","is","found","in","most","animal","cells","and","that","contains","a","variety","of","hydrolases",",","most","of","which","have","their","maximal","activities","in","the","pH","range","5-6",".","The","contained","enzymes","display","latency","if","properly","isolated",".","About","40","different","lysosomal","hydrolases","are","known","and","lysosomes","have","a","great","variety","of","morphologies","and","functions","."),4007710). assertion_content_comment('tOboGo_LysosomeToERCholesterolTransport',s("The","directed","movement","of","cholesterol",",","cholest-5-en-3-beta-ol",",","or","cholesterol-containing","compounds",",","from","the","lysosome","to","the","endoplasmic","reticulum","."),4154725). assertion_content_comment('tOboGo_LysosphingolipidAndLysophosphatidicAcidReceptorActivity',s("Combining","with","lysosphingolipid","or","lysophosphatidic","acid","to","initiate","a","change","in","cell","activity","."),4383612). assertion_content_comment('tOboGo_LysozymeActivity',s("Catalysis","of","the","hydrolysis","of","the","1",",","4-beta-linkages","between","N-acetylmuramic","acid","and","N-acetyl-D-glucosamine","residues","in","a","peptidoglycan","and","between","N-acetyl-D-glucosamine","residues","in","chitodextrins","."),4193015). assertion_content_comment('tOboGo_LysozymeInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","lysozyme",",","an","enzyme","that","hydrolyses","the","beta-","(","1",",","4",")","glycosidic","bond","between","N-acetylmuramic","acid","and","N-acetylglucosamine","in","peptidoglycan","."),4160084). assertion_content_comment('tOboGo_LysyltransferaseActivity',s("Catalysis","of","the","reaction",":","L-lysyl-tRNA","+","phosphatidylglycerol","=","tRNA","+","3-phosphatidyl-1","'","-","(","3","'","-O-L-lysyl",")","glycerol","."),4270951). assertion_content_comment('tOboGo_LyticEndotransglycosylaseActivity',s("Catalysis","of","the","specific","cleavage","of","the","beta-1",",","4","glycosidic","linkage","between","N-acetylmuramyl","and","N-acetylglucosaminyl","residues","in","peptidoglycan",",","with","the","concomitant","formation","of","1",",","6-anhydro-N-acetylmuramyl","residues",".","Acts","on","linkages","within","peptidoglycan","chains","(","i.e",".","not","at","the","ends",")","to","produce","shorter","strands","with","1",",","6-anhydromuramic","acid","ends","."),4248764). assertion_content_comment('tOboGo_LyticTransglycosylaseActivity',s("Catalysis","of","the","specific","cleavage","of","the","beta-1",",","4","glycosidic","linkage","between","N-acetylmuramyl","and","N-acetylglucosaminyl","residues","in","peptidoglycan",",","with","the","concomitant","formation","of","1",",","6-anhydro-N-acetylmuramyl","residues","."),4248720). assertion_content_comment('tOboGo_LyticVacuoleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","lytic","vacuole","."),4181175). assertion_content_comment('tOboGo_LyticVacuole',s("A","vacuole","that","is","maintained","at","an","acidic","pH","and","which","contains","degradative","enzymes",",","including","a","wide","variety","of","acid","hydrolases","."),3974398). assertion_content_comment('tOboGo_LyticVacuoleWithinProteinStorageVacuole',s("A","membrane-bounded","compartment","containing","crystals","of","phytic","acid","and","proteins","characteristic","of","a","lytic","vacuole",",","found","within","a","storage","vacuole","."),3974402). assertion_content_comment('tOboGo_LyticViralBudding',s("A","form","of","viral","release","in","which","the","viral","particles","bud","out","through","cellular","membranes",",","resulting","in","cell","lysis",".","It","is","also","a","form","of","viral","envelopment","."),4236646). assertion_content_comment('tOboGo_LyticViralExocytosis',s("The","exit","of","the","virion","particle","from","the","host","cell","by","exocytosis",",","resulting","in","cell","lysis","."),4356832). assertion_content_comment('tOboGo_LyticViralLifeCycle',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4306579). assertion_content_comment('tOboGo_LyticViralRelease',s("A","viral","infection","and","replication","that","leads","to","the","destruction","(","lysis",")","of","the","infected","cell","with","the","release","of","virions","."),4236636). assertion_content_comment('tOboGo_LyticVirusBuddingFromERMembrane',s("A","form","of","viral","release","in","which","the","nucleocapsid","evaginates","from","the","host","endoplasmic","reticulum","membrane","system",",","resulting","in","envelopment","of","the","virus","and","cell","lysis","."),4355148). assertion_content_comment('tOboGo_LyticVirusBuddingFromGolgiMembrane',s("A","form","of","viral","release","in","which","the","nucleocapsid","evaginates","from","the","host","Golgi","membrane","system",",","resulting","in","envelopment","of","the","virus","and","cell","lysis","."),4355161). assertion_content_comment('tOboGo_LyticVirusBuddingFromPlasmaMembrane',s("A","form","of","viral","release","in","which","the","nucleocapsid","evaginates","from","the","host","nuclear","membrane","system",",","resulting","in","envelopment","of","the","virus","and","cell","lysis","."),4355136). assertion_content_comment('tOboGo_M1MuscarinicAcetylcholineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","M1","muscarinic","acetylcholine","receptor","."),4323579). assertion_content_comment('tOboGo_M2MuscarinicAcetylcholineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","M2","muscarinic","acetylcholine","receptor","."),4323569). assertion_content_comment('tOboGo_M3MuscarinicAcetylcholineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","M3","muscarinic","acetylcholine","receptor","."),4323559). assertion_content_comment('tOboGo_M4MuscarinicAcetylcholineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","M4","muscarinic","acetylcholine","receptor","."),4323609). assertion_content_comment('tOboGo_M5MuscarinicAcetylcholineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","M5","muscarinic","acetylcholine","receptor","."),4323599). assertion_content_comment('tOboGo_M7G5PppNDiphosphataseActivity',s("Catalysis","of","the","reaction",":","7-methylguanosine","5","'","-triphospho-5","'","-polynucleotide","+","H2O","=","7-methylguanosine","5","'","-phosphate","+","polynucleotide","."),4270937). assertion_content_comment('tOboGo_Macroautophagy',s("The","major","inducible","pathway","for","the","general","turnover","of","cytoplasmic","constituents","in","eukaryotic","cells",",","it","is","also","responsible","for","the","degradation","of","active","cytoplasmic","enzymes","and","organelles","during","nutrient","starvation",".","Macroautophagy","involves","the","formation","of","double-membrane-bounded","autophagosomes","which","enclose","the","cytoplasmic","constituent","targeted","for","degradation","in","a","membrane-bounded","structure",",","which","then","fuse","with","the","lysosome","(","or","vacuole",")","releasing","a","single-membrane-bounded","autophagic","bodies","which","are","then","degraded","within","the","lysosome","(","or","vacuole",")","Though","once","thought","to","be","a","purely","non-selective","process",",","it","appears","that","some","types","of","macroautophagy",",","e.g",".","macropexophagy",",","macromitophagy",",","may","involve","selective","targeting","of","the","targets","to","be","degraded","."),3969819). assertion_content_comment('tOboGo_MacrolideBinding',s("Interacting","selectively","and","non-covalently","with","a","macrolide",",","any","of","a","large","group","of","structurally","related","antibiotics","produced","by","Streptomyces","species","."),4218736). assertion_content_comment('tOboGo_MacrolideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","leading","to","the","formation","of","macrolides",",","any","of","a","large","group","of","polyketide","compounds","that","contain","a","large","lactone","ring","with","few","or","no","double","bonds","and","no","nitrogen","atoms",",","linked","glycosidically","to","one","or","more","sugar","groups",".","The","macrolides","include","the","carbomycins",",","the","erythromycins",",","oleandomycin",",","oligomycins",",","and","the","spiramycins",",","and","act","as","antibiotics",",","mainly","against","Gram-positive","bacteria","."),4347313). assertion_content_comment('tOboGo_MacrolideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","macrolides",",","any","of","a","large","group","of","polyketide","compounds","that","contain","a","large","lactone","ring","with","few","or","no","double","bonds","and","no","nitrogen","atoms",",","linked","glycosidically","to","one","or","more","sugar","groups",".","The","macrolides","include","the","carbomycins",",","the","erythromycins",",","oleandomycin",",","oligomycins",",","and","the","spiramycins",",","and","act","as","antibiotics",",","mainly","against","Gram-positive","bacteria","."),4347310). assertion_content_comment('tOboGo_Macromitophagy',s("Degradation","of","a","mitochondrion","by","macroautophagy","."),4362578). assertion_content_comment('tOboGo_MacromolecularComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","macromolecules","to","form","a","complex","."),3969514). assertion_content_comment('tOboGo_MacromolecularComplexDisassembly',s("The","disaggregation","of","a","macromolecular","complex","into","its","constituent","components","."),3970603). assertion_content_comment('tOboGo_MacromolecularComplexRemodeling',s("The","acquisition",",","loss",",","or","modification","of","macromolecules","within","a","complex",",","resulting","in","the","alteration","of","an","existing","complex","."),3980444). assertion_content_comment('tOboGo_MacromolecularComplex',s("A","stable","assembly","of","two","or","more","macromolecules",",","i.e",".","proteins",",","nucleic","acids",",","carbohydrates","or","lipids",",","in","which","the","constituent","parts","function","together","."),3971344). assertion_content_comment('tOboGo_MacromolecularComplexSubunitOrganization',s("Any","process","in","which","macromolecules","aggregate",",","disaggregate",",","or","are","modified",",","resulting","in","the","formation",",","disassembly",",","or","alteration","of","a","macromolecular","complex","."),3969479). assertion_content_comment('tOboGo_MacromoleculeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","macromolecule",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3970944). assertion_content_comment('tOboGo_MacromoleculeCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","macromolecule",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3974265). assertion_content_comment('tOboGo_MacromoleculeGlycosylation',s("The","covalent","attachment","of","a","glycosyl","residue","to","one","or","more","monomeric","units","in","a","polypeptide",",","polynucleotide",",","polysaccharide",",","or","other","biological","macromolecule","."),4009761). assertion_content_comment('tOboGo_MacromoleculeLocalization',s("Any","process","in","which","a","macromolecule","is","transported","to",",","or","maintained","in",",","a","specific","location","."),3970221). assertion_content_comment('tOboGo_MacromoleculeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","macromolecules",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3968939). assertion_content_comment('tOboGo_MacromoleculeMethylation',s("The","covalent","attachment","of","a","methyl","residue","to","one","or","more","monomeric","units","in","a","polypeptide",",","polynucleotide",",","polysaccharide",",","or","other","biological","macromolecule","."),3975514). assertion_content_comment('tOboGo_MacromoleculeModification',s("The","covalent","alteration","of","one","or","more","monomeric","units","in","a","polypeptide",",","polynucleotide",",","polysaccharide",",","or","other","biological","macromolecule",",","resulting","in","a","change","in","its","properties","."),3972235). assertion_content_comment('tOboGo_MacromoleculeTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","macromolecule","from","one","side","of","the","membrane","to","the","other","."),4234258). assertion_content_comment('tOboGo_MacronucleusOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","macronucleus","."),4329227). assertion_content_comment('tOboGo_Macronucleus',s("A","membrane-bounded","organelle","of","ciliated","protozoan","cells","that","contains","polyploid","copies","of","a","portion","of","the","cell","'","s","complete","genome",".","Transcription","of","genes","occurs","in","macronuclei",".","Some","ciliate","species","may","contain","multiple","macronuclei","per","cell","."),4319350). assertion_content_comment('tOboGo_Macropexophagy',s("Degradation","of","a","peroxisome","by","macropexophagy","."),4362607). assertion_content_comment('tOboGo_MacrophageActivationInvolvedInImmuneResponse',s("A","change","in","morphology","and","behavior","of","a","macrophage","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4378465). assertion_content_comment('tOboGo_MacrophageActivation',s("A","change","in","morphology","and","behavior","of","a","macrophage","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),4094046). assertion_content_comment('tOboGo_MacrophageAntigenProcessingAndPresentation',s("The","process","in","which","a","macrophage","expresses","antigen","(","peptide","or","lipid",")","on","its","cell","surface","in","association","with","an","MHC","protein","complex","."),3994531). assertion_content_comment('tOboGo_MacrophageApoptosis',s("The","process","of","apoptosis","in","a","macrophage","."),4138374). assertion_content_comment('tOboGo_MacrophageChemotaxis',s("The","movement","of","a","macrophage","in","response","to","an","external","stimulus","."),4024964). assertion_content_comment('tOboGo_MacrophageCytokineProduction',s("The","appearance","of","a","macrophage","cytokine","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4034910). assertion_content_comment('tOboGo_MacrophageDerivedFoamCellDifferentiation',s("The","process","in","which","a","monocyte","acquires","the","specialized","features","of","a","foam","cell",".","A","foam","cell","is","a","type","of","cell","containing","lipids","in","small","vacuoles","and","typically","seen","in","atherosclerotic","lesions",",","as","well","as","other","conditions","."),4024643). assertion_content_comment('tOboGo_MacrophageDifferentiation',s("The","process","in","which","a","relatively","unspecialized","monocyte","acquires","the","specialized","features","of","a","macrophage","."),4087690). assertion_content_comment('tOboGo_MacrophageElastaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","soluble","and","insoluble","elastin",".","Specific","cleavages","are","also","produced","at","Ala14-Leu15","and","Tyr16-Leu17","in","the","B","chain","of","insulin","."),4209925). assertion_content_comment('tOboGo_MacrophageFusion',s("The","binding","and","fusion","of","a","macrophage","to","one","or","more","other","cells","to","form","a","multinucleated","cell","."),4075687). assertion_content_comment('tOboGo_MacrophageMigrationInhibitoryFactorBinding',s("Interacting","selectively","and","non-covalently","with","the","cytokine",",","macrophage","migration","inhibitory","factor","."),4380879). assertion_content_comment('tOboGo_MacrophageMigrationInhibitoryFactorReceptorComplex',s("A","protein","complex","that","binds","macrophage","migration","inhibitory","factor",".","Comprises","CD74","and","CD44","cell","surface","proteins","."),4380345). assertion_content_comment('tOboGo_MacrophageMigrationInhibitoryFactorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","macrophage","migration","inhibitory","factor","binding","to","a","cell","surface","receptor","."),4142332). assertion_content_comment('tOboGo_MacrophageReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4247334). assertion_content_comment('tOboGo_MacrophageToleranceInduction',s("A","process","involving","any","mechanism","for","tolerance","induction","in","macrophages","."),4034971). assertion_content_comment('tOboGo_MacrophomateSynthaseActivity',s("Catalysis","of","the","reaction",":","a","2-pyrone","+","oxalacetate","=","macrophomate","."),4347672). assertion_content_comment('tOboGo_MacropinocyticCupCytoskeleton',s("The","part","of","the","cortical","actin","cytoskeleton","that","forms","part","of","a","macropinocytic","cup","."),4130415). assertion_content_comment('tOboGo_MacropinocyticCupMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","macropinocytic","cup","."),4130426). assertion_content_comment('tOboGo_MacropinocyticCup',s("A","cell","projection","that","forms","at","the","site","of","macropinocytosis",",","a","form","of","endocytosis","that","results","in","the","uptake","of","relatively","large","amounts","of","extracellular","fluid",".","The","macropinocytic","cup","membrane","selectively","excludes","certain","proteins",",","such","as","H36","or","PM4C4","in","Dictyostelium",",","and","the","underlying","cytoskeleton","is","enriched","in","F-actin","and","coronin","."),4130412). assertion_content_comment('tOboGo_MaculaDensaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","macula","densa","over","time",",","from","its","formation","to","the","mature","structure",".","The","macula","densa","is","an","area","of","specialized","cells","in","the","distal","tubule","that","makes","contact","with","the","vascular","pole","of","the","glomerulus","."),4125191). assertion_content_comment('tOboGo_MagnesiumChelataseActivity',s("Catalysis","of","the","reaction",":","ATP","+","H","(","2",")","O","+","Mg","(","2","+",")","+","protoporphyrin","IX","=","ADP","+","2","H","(","+",")","+","magnesium","protoporphyrin","IX","+","phosphate","."),4301746). assertion_content_comment('tOboGo_MagnesiumChelataseComplex',s("A","heterotrimeric","enzyme","complex","composed","of","three","subunits",",","all","of","which","are","required","for","enzyme","activity",",","which","catalyzes","the","chelation","of","Mg","by","proto","IX","in","an","ATP-dependent","manner","."),4329943). assertion_content_comment('tOboGo_MagnesiumIonBinding',s("Interacting","selectively","and","non-covalently","with","magnesium","(","Mg",")","ions","."),4346692). assertion_content_comment('tOboGo_MagnesiumIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","magnesium","ions","within","an","organism","or","cell","."),4336138). assertion_content_comment('tOboGo_MagnesiumIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","magnesium","(","Mg",")","ions","from","one","side","of","a","membrane","to","the","other","."),4292102). assertion_content_comment('tOboGo_MagnesiumIonTransport',s("The","directed","movement","of","magnesium","(","Mg",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4289873). assertion_content_comment('tOboGo_MagnesiumProtoporphyrinIXMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","+","magnesium","protoporphyrin","IX","=","S-adenosyl-L-homocysteine","+","H","(","+",")","+","magnesium","protoporphyrin","IX","13-monomethyl","ester","."),4351358). assertion_content_comment('tOboGo_MagnetoreceptionBySensoryPerceptionOfChemicalStimulus',s("The","series","of","events","required","for","an","organism","to","receive","a","chemical","stimulus","relating","to","a","magnetic","field",",","convert","it","to","a","molecular","signal",",","and","recognize","and","characterize","the","signal",".","It","is","believed","that","organisms","such","as","birds","and","salamanders","use","a","'","chemical","compass","'",":","chemical","reactions","that","involve","transitions","between","different","spin","states","can","be","influenced","by","magnetic","fields","and","by","detecting","the","different","product","ratios",",","these","organisms","can","perceive","the","direction","of","the","magnetic","field",".","The","mechanism","by","which","this","is","detected","is","not","certain","but","it","may","also","involve","light","stimuli","."),4100462). assertion_content_comment('tOboGo_MagnetoreceptionBySensoryPerceptionOfElectricalStimulus',s("The","series","of","events","required","for","an","organism","to","receive","an","electrical","stimulus","relating","to","a","magnetic","field",",","convert","it","to","a","molecular","signal",",","and","recognize","and","characterize","the","signal",".","Movement","in","a","magnetic","field","results","in","an","induced","electric","field",",","which","can","be","perceived","by","organisms","such","as","elasmobranch","fish","."),4100297). assertion_content_comment('tOboGo_MagnetoreceptionBySensoryPerceptionOfMechanicalStimulus',s("The","series","of","events","required","for","an","organism","to","receive","a","mechanical","stimulus","relating","to","a","magnetic","field",",","convert","it","to","a","molecular","signal",",","and","recognize","and","characterize","the","signal",".","A","magnetic","field","exerts","a","torque","on","a","ferromagnetic","material","(","e.g",".","magnetite",")","or","on","a","material","with","diamagnetic","anisotropy",";","organisms","that","can","detect","this","torque","can","use","it","to","determine","the","orientation","of","the","magnetic","field","."),4100390). assertion_content_comment('tOboGo_Magnetoreception',s("The","series","of","events","required","for","an","organism","to","receive","a","stimulus","relating","to","a","magnetic","field",",","convert","it","to","a","molecular","signal",",","and","recognize","and","characterize","the","signal",".","Stimuli","may","be","chemical",",","mechanical","or","electrical","and","interpreting","these","stimuli","allows","an","organism","to","determine","the","orientation","of","a","magnetic","field",".","Magnetoreception","also","involves","the","perception","of","light",";","birds","cannot","orient","without","the","presence","of","short","wavelength","(","blue/green",")","light","."),4100293). assertion_content_comment('tOboGo_MainAxon',s("The","main","axonal","trunk",",","as","opposed","to","the","collaterals","."),4051589). assertion_content_comment('tOboGo_MainBodyFollicleCellMigration',s("The","ovarian","follicle","cell","migration","process","in","which","follicle","cells","migrate","posteriorly","to","form","a","columnar","epithelium","over","the","oocyte","."),4159928). assertion_content_comment('tOboGo_MaintenanceOfApicalBasalCellPolarity',s("Retaining","the","established","polarization","of","a","cell","along","its","apical/basal","axis","."),4300415). assertion_content_comment('tOboGo_MaintenanceOfBipolarCellPolarityRegulatingInCellShape',s("The","maintenance","of","established","bipolar","anisotropic","intracellular","organization","or","cell","growth","patterns","that","results","in","the","shaping","of","a","cell","."),4133660). assertion_content_comment('tOboGo_MaintenanceOfCellPolarity',s("The","maintenance","of","established","anisotropic","intracellular","organization","or","cell","growth","patterns","."),4299077). assertion_content_comment('tOboGo_MaintenanceOfCentrosomeLocation',s("Any","process","in","which","a","centrosome","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4121783). assertion_content_comment('tOboGo_MaintenanceOfChromatinSilencingAtTelomere',s("The","maintenance","of","chromatin","in","a","transcriptionally","silent","state","such","as","heterochromatin","at","the","telomere","."),4083233). assertion_content_comment('tOboGo_MaintenanceOfChromatinSilencing',s("The","maintenance","of","chromatin","in","a","transcriptionally","silent","state","such","as","heterochromatin","."),4009330). assertion_content_comment('tOboGo_MaintenanceOfChromosomeLocation',s("Any","process","in","which","a","chromosome","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4121829). assertion_content_comment('tOboGo_MaintenanceOfContractileRingLocalizationInvolvedInCellCycleCytokinesis',s("Any","process","in","which","a","contractile","ring","is","maintained","in","a","location","and","prevented","from","moving","elsewhere","."),4055382). assertion_content_comment('tOboGo_MaintenanceOfCRISPRRepeatElements',s("Any","process","involved","in","sustaining","CRISPR","repeat","clusters",",","including","capture","of","new","spacer","elements",",","expansion","or","contraction","of","clusters",",","propagation","of","the","leader","sequence","and","repeat","clusters","within","a","genome",",","transfer","of","repeat","clusters","and","CRISPR-associated","(","cas",")","genes","to","new","genomes",",","transcription","of","the","CRISPR","repeat","arrays","into","RNA","and","processing",",","and","interaction","of","CRISPR/cas","loci","with","the","host","genome",".","CRISPR","(","clustered","regularly","interspaced","short","palindromic","repeat",")","elements","are","a","family","of","sequence","elements","containing","multiple","direct","repeats","of","24-48","bp","with","weak","dyad","symmetry","which","are","separated","by","regularly","sized","nonrepetitive","spacer","sequences","."),4325662). assertion_content_comment('tOboGo_MaintenanceOfDauer',s("Maintenance","of","a","nematode","during","the","facultative","diapause","of","the","dauer","(","enduring",")","larval","stage","of","nematode","development","."),4094240). assertion_content_comment('tOboGo_MaintenanceOfDenseCoreGranuleLocation',s("Any","process","in","which","a","dense","core","granule","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4054034). assertion_content_comment('tOboGo_MaintenanceOfDiapause',s("The","dormancy","process","that","results","an","organism","remaining","in","diapause",".","Diapause","is","a","neurohormonally","mediated",",","dynamic","state","of","low","metabolic","activity",".","Associated","characteristics","of","this","form","of","dormancy","include","reduced","morphogenesis",",","increased","resistance","to","environmental","extremes",",","and","altered","or","reduced","behavioral","activity",".","Full","expression","develops","in","a","species-specific","manner",",","usually","in","response","to","a","number","of","environmental","stimuli","that","precede","unfavorable","conditions",".","Once","diapause","has","begun",",","metabolic","activity","is","suppressed","even","if","conditions","favorable","for","development","prevail",".","Once","initiated",",","only","certain","stimuli","are","capable","of","releasing","the","organism","from","this","state",",","and","this","characteristic","is","essential","in","distinguishing","diapause","from","hibernation","."),4094237). assertion_content_comment('tOboGo_MaintenanceOfDNAMethylation',s("Any","process","involved","in","maintaining","the","methylation","state","of","a","nucleotide","sequence","."),4031968). assertion_content_comment('tOboGo_MaintenanceOfDNARepeatElements',s("Any","process","involved","in","sustaining","the","fidelity","and","copy","number","of","DNA","repeat","elements","."),4299499). assertion_content_comment('tOboGo_MaintenanceOfDNATrinucleotideRepeats',s("Any","process","involved","in","sustaining","the","fidelity","and","copy","number","of","DNA","trinucleotide","repeats",".","DNA","trinucleotide","repeats","are","naturally","occurring","runs","of","three","base-pairs","."),4381245). assertion_content_comment('tOboGo_MaintenanceOfDosageCompensation',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4234426). assertion_content_comment('tOboGo_MaintenanceOfEndoplasmicReticulumLocationInvolvedInEndoplasmicReticulumPolarizationAtCellDivisionSite',s("The","process","in","which","the","endoplasmic","reticulum","is","maintained","at","the","site","of","cell","division","and","is","prevented","from","moving","elsewhere","."),4135761). assertion_content_comment('tOboGo_MaintenanceOfEpithelialCellApicalBasalPolarity',s("The","maintenance","of","the","apicobasal","polarity","of","an","epithelial","cell","."),4300418). assertion_content_comment('tOboGo_MaintenanceOfEpithelialIntegrityOpenTrachealSystem',s("Ensuring","that","tracheal","tubes","in","an","open","tracheal","system","maintain","their","epithelial","structure","during","the","cell","shape","changes","and","movements","that","occur","during","the","branching","process","."),4382096). assertion_content_comment('tOboGo_MaintenanceOfERLocation',s("Any","process","in","which","the","endoplasmic","reticulum","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4121992). assertion_content_comment('tOboGo_MaintenanceOfFloralMeristemIdentity',s("The","process","in","which","an","organism","retains","a","population","of","floral","meristem","cells",",","preventing","the","commitment","of","all","stem","cell","progeny","to","a","differentiated","cell","fate","."),4329615). assertion_content_comment('tOboGo_MaintenanceOfFloralOrganIdentity',s("The","process","in","which","the","identity","of","a","floral","organ","is","maintained",".","Identity","is","considered","to","be","the","aggregate","of","characteristics","by","which","a","structure","is","recognized","."),4103161). assertion_content_comment('tOboGo_MaintenanceOfGastrointestinalEpithelium',s("Protection","of","epithelial","surfaces","of","the","gastrointestinal","tract","from","proteolytic","and","caustic","digestive","agents","."),4110780). assertion_content_comment('tOboGo_MaintenanceOfGolgiLocation',s("Any","process","in","which","the","Golgi","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4121869). assertion_content_comment('tOboGo_MaintenanceOfGranzymeBLocationInTCellSecretoryGranule',s("A","process","in","which","the","protease","granyme","B","is","maintained","in","a","secretory","granule","in","a","T","cell","and","prevented","from","moving","elsewhere","."),4063326). assertion_content_comment('tOboGo_MaintenanceOfImaginalHistoblastDiploidy',s("The","negative","regulation","of","the","differentiation","of","polytenized","larval","hypodermal","cells","from","abdominal","histoblasts",".","The","abdominal","histoblasts","remain","a","small","cluster","of","diploid","cells","among","the","polytenized","larval","hypodermal","cells","."),4018230). assertion_content_comment('tOboGo_MaintenanceOfInflorescenceMeristemIdentity',s("The","process","in","which","an","organism","retains","a","population","of","inflorescence","meristem","cells",",","preventing","the","commitment","of","all","stem","cell","progeny","to","a","differentiated","cell","fate","."),4329606). assertion_content_comment('tOboGo_MaintenanceOfKidneyIdentity',s("The","process","in","which","the","identity","of","a","kidney","is","maintained",".","Identity","is","considered","to","be","the","aggregate","of","characteristics","by","which","a","structure","is","recognized","."),4125813). assertion_content_comment('tOboGo_MaintenanceOfLocationInCell',s("Any","process","in","which","a","substance","or","cellular","entity",",","such","as","a","protein","complex","or","organelle",",","is","maintained","in","a","specific","location","within",",","or","in","the","membrane","of",",","a","cell",",","and","is","prevented","from","moving","elsewhere","."),4011738). assertion_content_comment('tOboGo_MaintenanceOfLocation',s("Any","process","in","which","a","cell",",","substance","or","cellular","entity",",","such","as","a","protein","complex","or","organelle",",","is","maintained","in","a","location","and","prevented","from","moving","elsewhere","."),4011696). assertion_content_comment('tOboGo_MaintenanceOfMeioticSisterChromatidCohesion',s("The","process","in","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","as","chromosomes","condense",",","attach","to","the","spindle","in","a","bipolar","orientation",",","and","congress","to","the","metaphase","plate","during","a","meiotic","cell","cycle","."),4076598). assertion_content_comment('tOboGo_MaintenanceOfMembranePotentialInPhotoreceptorCellByRhodopsinMediatedSignaling',s("Maintenance","of","the","excited","state","of","a","photoreceptor","cell","to","produce","a","steady-state","current","as","a","result","of","signals","generated","by","rhodopsin","activation","by","a","photon","."),4303429). assertion_content_comment('tOboGo_MaintenanceOfMeristemIdentity',s("The","process","in","which","an","organism","retains","a","population","of","meristem","cells",",","preventing","the","commitment","of","all","stem","cell","progeny","to","a","differentiated","cell","fate","."),4032546). assertion_content_comment('tOboGo_MaintenanceOfMitochondrionLocation',s("Any","process","in","which","a","mitochondrion","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4121794). assertion_content_comment('tOboGo_MaintenanceOfMitoticSisterChromatidCohesion',s("The","process","in","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","as","chromosomes","condense",",","attach","to","the","spindle","in","a","bipolar","orientation",",","and","congress","to","the","metaphase","plate","during","a","mitotic","cell","cycle","."),4075987). assertion_content_comment('tOboGo_MaintenanceOfNeuroblastPolarity',s("The","maintenance","of","the","apicobasal","polarity","of","a","neuroblast","cell",",","a","progenitor","of","the","central","nervous","system","."),4299080). assertion_content_comment('tOboGo_MaintenanceOfNucleusLocation',s("Any","process","in","which","the","nucleus","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4080470). assertion_content_comment('tOboGo_MaintenanceOfOocyteNucleusLocationInvolvedInOocyteDorsalVentralAxisSpecification',s("Maintenance","of","the","oocyte","nucleus","in","a","particular","position","within","the","cell","during","the","establishment","and","maintenance","of","the","axes","of","the","oocyte",".","An","example","of","this","process","is","found","In","Drosophila","melanogaster","."),4080475). assertion_content_comment('tOboGo_MaintenanceOfOrganelleLocation',s("Any","process","in","which","an","organelle","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4053991). assertion_content_comment('tOboGo_MaintenanceOfOrganIdentity',s("The","process","in","which","the","identity","of","an","organ","is","maintained",".","Identity","is","considered","to","be","the","aggregate","of","characteristics","by","which","a","structure","is","recognized","."),4103158). assertion_content_comment('tOboGo_MaintenanceOfPigmentGranuleLocation',s("Any","process","in","which","a","pigment","granule","is","maintained","in","a","location","and","prevented","from","moving","elsewhere","."),4120220). assertion_content_comment('tOboGo_MaintenanceOfPlastidLocation',s("Any","process","in","which","a","plastid","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4121945). assertion_content_comment('tOboGo_MaintenanceOfPolarityOfEmbryonicEpithelium',s("The","maintenance","of","an","established","polarized","embryonic","epithelial","sheet","."),4314626). assertion_content_comment('tOboGo_MaintenanceOfPolarityOfFollicularEpithelium',s("The","maintenance","of","an","established","polarized","follicular","epithelial","sheet","."),4314654). assertion_content_comment('tOboGo_MaintenanceOfPolarityOfLarvalImaginalDiscEpithelium',s("The","maintenance","of","an","established","polarized","larval","imaginal","disc","epithelium","."),4314635). assertion_content_comment('tOboGo_MaintenanceOfPolePlasmMRNALocation',s("The","process","of","maintaining","mRNA","in","a","specific","location","in","the","oocyte","pole","plasm",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4098599). assertion_content_comment('tOboGo_MaintenanceOfPresynapticActiveZoneStructure',s("The","process","in","which","a","neuronal","cell","maintains","the","organization","and","the","arrangement","of","proteins","at","the","active","zone","to","ensure","the","fusion","and","dock","of","vesicles","and","the","release","of","neurotransmitters","."),4330170). assertion_content_comment('tOboGo_MaintenanceOfProteaseLocationInMastCellSecretoryGranule',s("A","process","in","which","a","protease","is","maintained","in","a","secretory","granule","in","a","mast","cell","and","prevented","from","moving","elsewhere","."),4063264). assertion_content_comment('tOboGo_MaintenanceOfProteaseLocationInTCellSecretoryGranule',s("A","process","in","which","a","protease","is","maintained","in","a","secretory","granule","in","a","T","cell","and","prevented","from","moving","elsewhere","."),4063178). assertion_content_comment('tOboGo_MaintenanceOfProteinLocalizationInEndoplasmicReticulum',s("Any","process","in","which","a","protein","is","maintained","in","the","endoplasmic","reticulum","and","prevented","from","moving","elsewhere",".","These","include","sequestration","within","the","endoplasmic","reticulum",",","protein","stabilization","to","prevent","transport","elsewhere","and","the","active","retrieval","of","proteins","that","escape","the","endoplasmic","reticulum","."),4082907). assertion_content_comment('tOboGo_MaintenanceOfProteinLocalizationToOrganelle',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","a","specific","location","on","or","in","an","organelle",",","and","is","prevented","from","moving","elsewhere",".","Encompasses","establishment","of","localization","in","the","membrane","or","lumen","of","a","membrane-bounded","organelle","."),4082904). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationAtSpindlePoleBody',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","at","the","spindle","pole","body",",","and","is","prevented","from","moving","elsewhere","."),4125781). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInCell',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","within",",","or","in","the","membrane","of",",","a","cell",",","and","is","prevented","from","moving","elsewhere","."),4016465). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInChloroplast',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","in","a","chloroplast",",","and","is","prevented","from","moving","elsewhere","."),4126591). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInExtracellularRegion',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","within","the","extracellular","region","and","is","prevented","from","moving","elsewhere","."),4129007). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInMastCellSecretoryGranule',s("A","process","in","which","a","protein","is","maintained","in","a","secretory","granule","in","a","mast","cell","and","prevented","from","moving","elsewhere","."),4063259). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInMembrane',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","in","a","membrane",",","and","is","prevented","from","moving","elsewhere","."),4146847). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInMitochondrion',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","in","a","mitochondrion",",","and","is","prevented","from","moving","elsewhere","."),4158051). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInNucleus',s("Any","process","in","which","a","protein","is","maintained","in","the","nucleus","and","prevented","from","moving","elsewhere",".","These","include","sequestration","within","the","nucleus",",","protein","stabilization","to","prevent","transport","elsewhere","and","the","active","retrieval","of","proteins","that","escape","the","nucleus","."),4118546). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInPeroxisome',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","in","a","peroxisome",",","and","is","prevented","from","moving","elsewhere","."),4146826). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInPlasmaMembrane',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","in","the","plasma","membrane",",","and","is","prevented","from","moving","elsewhere","."),4146868). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInTCellSecretoryGranule',s("A","process","in","which","a","protein","is","maintained","in","a","secretory","granule","in","a","T","cell","and","prevented","from","moving","elsewhere","."),4063151). assertion_content_comment('tOboGo_MaintenanceOfProteinLocationInVacuole',s("Any","process","in","which","a","protein","is","maintained","in","a","specific","location","in","a","vacuole",",","and","is","prevented","from","moving","elsewhere","."),4146816). assertion_content_comment('tOboGo_MaintenanceOfProteinLocation',s("Any","process","in","which","a","protein","is","maintained","in","a","location","and","prevented","from","moving","elsewhere",".","These","include","sequestration",",","stabilization","to","prevent","transport","elsewhere","and","the","active","retrieval","of","proteins","that","do","move","away","."),4016458). assertion_content_comment('tOboGo_MaintenanceOfRDNA',s("Any","process","involved","in","sustaining","the","fidelity","and","copy","number","of","rDNA","repeats","."),4299501). assertion_content_comment('tOboGo_MaintenanceOfReproductiveDiapause',s("The","dormancy","process","that","results","an","organism","remaining","in","reproductive","diapause",".","Reproductive","diapause","is","a","form","of","diapause","where","the","organism","itself","will","remain","fully","active",",","including","feeding","and","other","routine","activities",",","but","the","reproductive","organs","experience","a","tissue-specific","reduction","in","metabolism",",","with","characteristic","triggering","and","releasing","stimuli","."),4168840). assertion_content_comment('tOboGo_MaintenanceOfRNALocation',s("Any","process","in","which","RNA","is","maintained","in","a","location","and","prevented","from","moving","elsewhere","."),4098594). assertion_content_comment('tOboGo_MaintenanceOfRootMeristemIdentity',s("The","process","in","which","an","organism","retains","a","population","of","root","meristem","cells",",","preventing","the","commitment","of","all","stem","cell","progeny","to","a","differentiated","cell","fate","."),4032558). assertion_content_comment('tOboGo_MaintenanceOfSecretoryGranuleLocation',s("Any","process","in","which","a","secretory","granule","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4053999). assertion_content_comment('tOboGo_MaintenanceOfSeedDormancy',s("Any","process","that","maintains","a","seed","in","a","dormant","state","."),4031980). assertion_content_comment('tOboGo_MaintenanceOfShootApicalMeristemIdentity',s("The","process","in","which","an","organism","retains","a","population","of","shoot","apical","meristem","cells",",","preventing","the","commitment","of","all","stem","cell","progeny","to","a","differentiated","cell","fate","."),4332734). assertion_content_comment('tOboGo_MaintenanceOfSisterChromatidCohesion',s("The","process","in","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","as","chromosomes","condense",",","attach","to","the","spindle","in","a","bipolar","orientation",",","and","congress","to","the","metaphase","plate","."),4075984). assertion_content_comment('tOboGo_MaintenanceOfSpindleLocation',s("Any","process","in","which","the","spindle","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4121956). assertion_content_comment('tOboGo_MaintenanceOfStationaryPhaseInResponseToStarvation',s("The","homeostatic","process","in","which","a","population","of","cells","changes","its","metabolic","activity","resulting","in","the","rate","of","death","in","the","population","equaling","the","rate","of","reproduction","in","response","to","limited","nutrients","in","the","environment","."),4159910). assertion_content_comment('tOboGo_MaintenanceOfStationaryPhaseInResponseToToxin',s("The","homeostatic","process","in","which","a","population","of","cells","changes","its","metabolic","activity","resulting","in","the","rate","of","death","in","the","population","equaling","the","rate","of","reproduction","in","response","to","a","build-up","of","toxins","in","the","environment","."),4159958). assertion_content_comment('tOboGo_MaintenanceOfStationaryPhase',s("The","homeostatic","process","in","which","a","population","of","cells","changes","its","metabolic","activity","resulting","in","the","rate","of","death","in","the","population","equaling","the","rate","of","reproduction",".","Stationary","phase","can","be","in","response","to","limited","nutrients","or","a","build-up","of","toxic","substances","in","the","environment","."),4159900). assertion_content_comment('tOboGo_MaintenanceOfSymbiontToleranceToHostDefenseMolecules',s("Any","process","that","contributes","to","the","maintenance","of","a","physiologic","state","in","which","the","symbiont","immune","system","does","not","react","destructively","against","defense","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153390). assertion_content_comment('tOboGo_MaintenanceOfSymbiontToleranceToHostEnvironment',s("Any","process","that","contributes","to","the","maintenance","of","a","physiologic","state","in","which","the","symbiont","immune","system","does","not","react","destructively","against","the","components","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153346). assertion_content_comment('tOboGo_MaintenanceOfSymbiontToleranceToHostIronConcentration',s("Any","process","that","contributes","to","the","maintenance","of","a","physiologic","state","in","which","the","symbiont","immune","system","does","not","react","destructively","against","iron","concentration","environment","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153401). assertion_content_comment('tOboGo_MaintenanceOfSymbiontToleranceToHostOsmoticEnvironment',s("Any","process","that","contributes","to","the","maintenance","of","a","physiologic","state","in","which","the","symbiont","immune","system","does","not","react","destructively","against","osmotic","environment","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153422). assertion_content_comment('tOboGo_MaintenanceOfSymbiontToleranceToHostOxygenTensionEnvironment',s("Any","process","that","contributes","to","the","maintenance","of","a","physiologic","state","in","which","the","symbiont","immune","system","does","not","react","destructively","against","oxygen","tension","environment","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153379). assertion_content_comment('tOboGo_MaintenanceOfSymbiontToleranceToHostPHEnvironment',s("Any","process","that","contributes","to","the","maintenance","of","a","physiologic","state","in","which","the","symbiont","immune","system","does","not","react","destructively","against","pH","environment","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154441). assertion_content_comment('tOboGo_MaintenanceOfSymbiontToleranceToHostRedoxEnvironment',s("Any","process","that","contributes","to","the","maintenance","of","a","physiologic","state","in","which","the","symbiont","immune","system","does","not","react","destructively","against","redox","environment","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153368). assertion_content_comment('tOboGo_MaintenanceOfTurgorInAppressoriumByMelanization',s("The","process","in","which","melanin","is","produced","in","the","appressorium","of","the","symbiont","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153808). assertion_content_comment('tOboGo_MaintenanceOfVegetativeMeristemIdentity',s("The","process","in","which","an","organism","retains","a","population","of","vegetative","meristem","cells",",","preventing","the","commitment","of","all","stem","cell","progeny","to","a","differentiated","cell","fate","."),4329597). assertion_content_comment('tOboGo_MaintenanceOfVesicleLocation',s("Any","process","in","which","a","vesicle","is","maintained","in","a","specific","location","within","a","cell","and","prevented","from","moving","elsewhere","."),4053995). assertion_content_comment('tOboGo_MajorHistocompatibilityComplexAntigen',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4188123). assertion_content_comment('tOboGo_MajorMitochondrialDerivative',s("The","larger","of","the","two","mitochondrial","derivatives","that","arise","by","the","unfolding","of","the","Nebenkern","during","flagellum","elongation",";","the","major","mitochondrial","derivative","is","ovoid","and","darker","than","the","minor","derivative","."),4302741). assertion_content_comment('tOboGo_MajorUrinaryProtein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217555). assertion_content_comment('tOboGo_MalateDehydrogenaseActivity',s("Catalysis","of","the","reversible","conversion","of","pyruvate","or","oxaloacetate","to","malate","."),4186737). assertion_content_comment('tOboGo_MalateDehydrogenaseDecarboxylatingActivity',s("Catalysis","of","the","reaction",":","(","S",")","-malate","+","NAD","+","=","pyruvate","+","CO2","+","NADH","+","H","+","Does","not","decarboxylate","oxaloacetate","."),4205544). assertion_content_comment('tOboGo_MalateDehydrogenaseMenaquinoneActivity',s("Catalysis","of","the","reaction",":","(","S",")","-malate","+","a","menaquinone","=","oxaloacetate","+","a","menaquinol","."),4186740). assertion_content_comment('tOboGo_MalateDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","(","S",")","-malate","+","NADP","+","=","oxaloacetate","+","NADPH","+","H","+"),4359049). assertion_content_comment('tOboGo_MalateDehydrogenaseQuinoneActivity',s("Catalysis","of","the","reaction",":","(","S",")","-malate","+","a","quinone","=","oxaloacetate","+","a","quinol","."),4248616). assertion_content_comment('tOboGo_Malate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","malate","(","out",")","+","H","+","(","out",")","=","malate","(","in",")","+","H","+","(","in",")"),4296012). assertion_content_comment('tOboGo_MalateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","malate",",","the","anion","of","hydroxybutanedioic","acid",",","a","chiral","hydroxydicarboxylic","acid",".","The","(","+",")","enantiomer","is","an","important","intermediate","in","metabolism","as","a","component","of","both","the","TCA","cycle","and","the","glyoxylate","cycle","."),4224437). assertion_content_comment('tOboGo_MalateOxidaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-malate","+","O","(","2",")","=","H","(","2",")","O","(","2",")","+","oxaloacetate","."),4237558). assertion_content_comment('tOboGo_Malate_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","malate","(","out",")","+","Na","+","(","out",")","=","malate","(","in",")","+","Na","+","(","in",")"),4326728). assertion_content_comment('tOboGo_MalateSynthaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","glyoxylate","+","H","(","2",")","O","=","(","S",")","-malate","+","CoA","+","H","(","+",")"),4205608). assertion_content_comment('tOboGo_MalateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","malate","from","one","side","of","the","membrane","to","the","other",".","Malate","is","a","chiral","hydroxydicarboxylic","acid",",","hydroxybutanedioic","acid",".","The","(","+",")","enantiomer","is","an","important","intermediate","in","metabolism","as","a","component","of","both","the","TCA","cycle","and","the","glyoxylate","cycle","."),4228482). assertion_content_comment('tOboGo_MalateTransmembraneTransport',s("A","process","in","which","a","malate","ion","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4164078). assertion_content_comment('tOboGo_MalateTransport',s("The","directed","movement","of","malate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4164074). assertion_content_comment('tOboGo_MaleAnaliaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","analia","of","the","male","over","time",",","from","formation","to","the","mature","structure",".","The","analia","is","the","posterior-most","vertral","appendage","that","develops","from","the","genital","disc",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4105113). assertion_content_comment('tOboGo_MaleAnaliaMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","analia","of","the","male","are","generated","and","organized",".","The","analia","is","the","posterior-most","vertral","appendage","that","develops","from","the","genital","disc","."),4105123). assertion_content_comment('tOboGo_MaleateHydrataseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-malate","=","H","(","2",")","O","+","maleate","."),4270998). assertion_content_comment('tOboGo_MaleateIsomeraseActivity',s("Catalysis","of","the","reaction",":","maleate","=","fumarate","."),4270988). assertion_content_comment('tOboGo_MaleCourtshipBehaviorOrientationPriorToLegTappingAndWingVibration',s("The","process","during","courtship",",","where","the","male","orients","towards","a","potential","partner",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4305291). assertion_content_comment('tOboGo_MaleCourtshipBehavior',s("The","actions","or","reactions","of","a","male",",","for","the","purpose","of","attracting","a","sexual","partner",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4015062). assertion_content_comment('tOboGo_MaleCourtshipBehaviorTappingToDetectPheromone',s("The","process","during","courtship","where","the","male","insect","taps","the","female","with","his","frontal","leg",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4305303). assertion_content_comment('tOboGo_MaleCourtshipBehaviorVeinedWingExtension',s("The","process","during","courtship","where","the","male","insect","extends","his","wings",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4089538). assertion_content_comment('tOboGo_MaleCourtshipBehaviorVeinedWingGeneratedSongProduction',s("The","process","during","wing","vibration","where","the","male","insect","produces","a","species-specific","acoustic","signal","called","a","love","song","."),4089556). assertion_content_comment('tOboGo_MaleCourtshipBehaviorVeinedWingVibration',s("The","process","during","courtship","where","the","male","insect","vibrates","his","wings",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4089543). assertion_content_comment('tOboGo_MaleGameteGeneration',s("Generation","of","the","male","gamete",";","specialised","haploid","cells","produced","by","meiosis","and","along","with","a","female","gamete","takes","part","in","sexual","reproduction","."),3982230). assertion_content_comment('tOboGo_MaleGenitaliaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","male","genitalia","over","time",",","from","its","formation","to","the","mature","structure","."),4046692). assertion_content_comment('tOboGo_MaleGenitaliaMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","male","genitalia","are","generated","and","organized","."),4105144). assertion_content_comment('tOboGo_MaleGermCellNucleus',s("The","nucleus","of","a","male","germ","cell",",","a","reproductive","cell","in","males","."),4383633). assertion_content_comment('tOboGo_MaleGermCellProliferation',s("The","multiplication","or","reproduction","of","male","germ","cells",",","resulting","in","the","expansion","of","a","cell","population","."),3993267). assertion_content_comment('tOboGo_MaleGermlineRingCanalFormation',s("Formation","of","the","intercellular","bridges","that","connect","the","germ-line","cells","of","a","male","cyst","."),4052076). assertion_content_comment('tOboGo_MaleGermlineRingCanal',s("An","intercellular","bridge","that","connects","the","germline","cells","of","a","male","cyst","."),4382910). assertion_content_comment('tOboGo_MaleGonadDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","male","gonad","over","time",",","from","its","formation","to","the","mature","structure","."),4020237). assertion_content_comment('tOboGo_MaleimideHydrolaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","maleimide","=","H","(","+",")","+","maleamate","."),4268684). assertion_content_comment('tOboGo_MaleMatingBehavior',s("The","specific","actions","or","reactions","of","a","male","organism","that","are","associated","with","reproduction","."),4015059). assertion_content_comment('tOboGo_MaleMeiosisCentrosomeCycle',s("Centrosome","duplication","and","separation","in","the","context","of","a","meiotic","cell","cycle","in","a","male","organism","."),4012565). assertion_content_comment('tOboGo_MaleMeiosisChromosomeSegregation',s("The","cell","cycle","process","in","which","genetic","material",",","in","the","form","of","chromosomes",",","is","organized","and","then","physically","separated","and","apportioned","to","two","or","more","sets","during","the","meiotic","cell","cycle","in","a","male","."),4013053). assertion_content_comment('tOboGo_MaleMeiosisChromosomeSeparation',s("The","process","in","which","paired","chromosomes","are","physically","detached","from","each","other","during","male","meiosis","."),4286181). assertion_content_comment('tOboGo_MaleMeiosisCytokinesis',s("A","cell","cycle","process","that","occurs","as","part","of","the","male","meiotic","cell","cycle","and","results","in","the","division","of","the","cytoplasm","of","a","cell","to","produce","two","daughter","cells","."),4236047). assertion_content_comment('tOboGo_MaleMeiosisII',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","male","meiosis","II",",","the","second","meiotic","division","in","the","male","germline","."),4011920). assertion_content_comment('tOboGo_MaleMeiosisI',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","male","meiosis","I",",","the","first","meiotic","division","in","the","male","germline","."),4011910). assertion_content_comment('tOboGo_MaleMeiosis',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","nuclear","division","phase","of","a","meiotic","cell","cycle","in","the","male","germline","."),4011900). assertion_content_comment('tOboGo_MaleMeiosisSisterChromatidCohesion',s("The","joining","of","the","sister","chromatids","of","a","replicated","chromosome","along","the","entire","length","of","the","chromosome","that","occurs","during","meiosis","in","a","male","."),4013127). assertion_content_comment('tOboGo_MaleMeioticChromosomeMovementTowardsSpindlePole',s("The","directed","movement","of","chromosomes","in","the","center","of","the","spindle","towards","the","spindle","poles",",","mediated","by","the","shortening","of","microtubules","attached","to","the","chromosomes",",","during","male","meiosis","."),4034460). assertion_content_comment('tOboGo_MalePigmentation',s("Establishment","of","a","pattern","of","pigment","in","males","."),4104308). assertion_content_comment('tOboGo_MalePronuclearEnvelopeSynthesis',s("Assembly","of","a","nuclear","envelope","containing","nuclear","pores","and","a","lamina","around","the","male","pronucleus",",","the","final","step","in","sperm","pronuclear","formation","."),4072673). assertion_content_comment('tOboGo_MalePronucleusAssembly',s("The","conversion","at","fertilization","of","the","inactive","sperm","nucleus","into","a","male","pronucleus","with","its","chromosomes","processed","for","the","first","zygotic","division","."),4072640). assertion_content_comment('tOboGo_MalePronucleus',s("The","pronucleus","originating","from","the","spermatozoa","that","was","involved","in","fertilization","."),4384140). assertion_content_comment('tOboGo_MaleSexDetermination',s("The","specification","of","male","sex","of","an","individual","organism","."),4049188). assertion_content_comment('tOboGo_MaleSexDifferentiation',s("The","establishment","of","the","sex","of","a","male","organism","by","physical","differentiation","."),3986504). assertion_content_comment('tOboGo_MaleSomaticSexDetermination',s("The","determination","of","sex","and","sexual","phenotypes","in","a","male","organism","'","s","soma","."),4237072). assertion_content_comment('tOboGo_MaleUrethraDevelopment',s("The","progression","of","the","male","urethra","over","time","from","its","initial","formation","to","the","mature","structure",".","The","male","urethra","is","a","renal","system","organ","that","carries","urine","from","the","bladder","through","the","penis","to","outside","the","body","."),4155943). assertion_content_comment('tOboGo_MaleylacetateReductaseActivity',s("Catalysis","of","the","reaction",":","3-oxoadipate","+","NAD","(","P",")","+","=","2-maleylacetate","+","NAD","(","P",")","H","+","H","+"),4278585). assertion_content_comment('tOboGo_MaleylacetoacetateIsomeraseActivity',s("Catalysis","of","the","reaction",":","4-maleylacetoacetate","=","4-fumarylacetoacetate","."),4302615). assertion_content_comment('tOboGo_MaleylpyruvateIsomeraseActivity',s("Catalysis","of","the","reaction",":","3-maleylpyruvate","=","3-fumarylpyruvate","."),4271023). assertion_content_comment('tOboGo_MalicAcidSecretion',s("The","controlled","release","of","malic","acid",",","hydroxybutanedioic","(","hydroxysuccinic",")","acid",",","by","a","cell","or","group","of","cells","."),4356950). assertion_content_comment('tOboGo_MalicEnzymeActivity',s("Catalysis","of","the","oxidative","decarboxylation","of","malate","with","the","concomitant","production","of","pyruvate","."),4205540). assertion_content_comment('tOboGo_MalolacticEnzymeActivity',s("Catalysis","of","the","reaction",":","malate","+","H","+","=","L-lactate","+","CO2","."),4326750). assertion_content_comment('tOboGo_MalolacticFermentation',s("The","anaerobic","enzymatic","conversion","of","L-malate","to","L-lactate","and","carbon","dioxide",",","yielding","energy","in","the","form","of","ATP","."),4325013). assertion_content_comment('tOboGo_MalonateSemialdehydeDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","malonate","semialdehyde","+","H","+","=","acetaldehyde","+","CO2","."),4348732). assertion_content_comment('tOboGo_MalonyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","malonyl","(","HOOC-CH2-CO-",")","group","to","an","acceptor","molecule","."),4208784). assertion_content_comment('tOboGo_MalpighianTubuleBudMorphogenesis',s("The","morphogenetic","process","in","which","a","bud","forms","from","the","embryonic","hindgut","tube","to","form","the","Malpighian","tubule",".","A","bud","is","a","protrusion","that","forms","from","the","tube","by","localized","changes","in","cell","shape","and","position","."),4134929). assertion_content_comment('tOboGo_MalpighianTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","Malpighian","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","A","Malpighian","tubule","is","a","fine",",","thin-walled","excretory","tubule","in","insects","which","leads","into","the","posterior","part","of","the","gut","."),4017553). assertion_content_comment('tOboGo_MalpighianTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","Malpighian","tubule","are","generated","and","organized",".","This","process","takes","place","entirely","during","the","embryonic","phase",".","A","Malpighian","tubule","is","a","fine",",","thin-walled","excretory","tubule","in","insects","which","leads","into","the","posterior","part","of","the","gut","."),4017634). assertion_content_comment('tOboGo_MalpighianTubulePrincipalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","Malpighian","tubule","principal","cell",".","A","Malpighian","tubule","principal","cell","is","an","epithelial","secretory","cell","that","transports","cations","into","the","lumen","of","the","tubule","."),4134918). assertion_content_comment('tOboGo_MalpighianTubuleStellateCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","Malpighian","tubule","stellate","cell",".","A","Malpighian","tubule","stellate","cell","is","a","specialized","epithelial","secretory","cell","that","moves","chloride","ions","and","water","across","the","tubule","epithelium","."),4134950). assertion_content_comment('tOboGo_MalpighianTubuleTipCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","Malpighian","tubule","tip","cell",".","A","Malpighian","tubule","tip","cell","is","a","mitogenic","signaling","cell","that","controls","the","proliferation","of","its","neighboring","cells","."),4133471). assertion_content_comment('tOboGo_MaltodextrinPhosphorylaseActivity',s("Catalysis","of","the","reaction",":","maltodextrin","=","glucose-1-phosphate","."),4319992). assertion_content_comment('tOboGo_MaltodextrinTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","maltodextrin",",","any","polysaccharide","of","glucose","residues","in","beta-","(","1",",","4",")","linkage",",","from","one","side","of","the","membrane","to","the","other","."),4316326). assertion_content_comment('tOboGo_MaltodextrinTransport',s("The","directed","movement","of","maltodextrin",",","any","polysaccharide","of","glucose","residues","in","beta-","(","1",",","4",")","linkage",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4316346). assertion_content_comment('tOboGo_MaltoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","disaccharide","maltose","(","4-O-alpha-D-glucopyranosyl-D-glucopyranose",")"),4345474). assertion_content_comment('tOboGo_MaltoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","disaccharide","maltose","(","4-O-alpha-D-glucopyranosyl-D-glucopyranose",")"),4345458). assertion_content_comment('tOboGo_MaltoseEpimeraseActivity',s("Catalysis","of","the","reaction",":","alpha-maltose","=","beta-maltose","."),4268157). assertion_content_comment('tOboGo_Maltose_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","maltose","(","out",")","+","H","+","(","out",")","=","maltose","(","in",")","+","H","+","(","in",")"),4216653). assertion_content_comment('tOboGo_MaltoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","disaccharide","maltose","(","4-O-alpha-D-glucopyranosyl-D-glucopyranose",")",",","an","intermediate","in","the","catabolism","of","glycogen","and","starch","."),4345452). assertion_content_comment('tOboGo_MaltosePhosphorylaseActivity',s("Catalysis","of","the","reaction",":","maltose","+","phosphate","=","D-glucose","+","beta-D-glucose","1-phosphate","."),4270603). assertion_content_comment('tOboGo_MaltoseSynthaseActivity',s("Catalysis","of","the","reaction",":","2","alpha-D-glucose","1-phosphate","=","maltose","+","2","phosphate","."),4266870). assertion_content_comment('tOboGo_MaltoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","maltose","from","one","side","of","the","membrane","to","the","other",".","Maltose","is","the","disaccharide","4-O-alpha-D-glucopyranosyl-D-glucopyranose",",","an","intermediate","in","the","enzymatic","breakdown","of","glycogen","and","starch","."),4216642). assertion_content_comment('tOboGo_MaltoseTransportingPorinActivity',s("Catalysis","of","the","transfer","of","maltose","from","one","side","of","the","membrane","to","the","other",".","Maltose","is","the","disaccharide","4-O-alpha-D-glucopyranosyl-D-glucopyranose",",","an","intermediate","in","the","enzymatic","breakdown","of","glycogen","and","starch",".","This","transporter","is","a","porin","so","enables","the","energy","independent","passage","of","substances",",","sized","less","than","1000","Da",",","across","a","membrane",".","The","transmembrane","portions","of","porins","consist","exclusively","of","beta-strands","which","form","a","beta-barrel",".","They","are","found","in","the","outer","membranes","of","Gram-negative","bacteria",",","mitochondria",",","plastids","and","possibly","acid-fast","Gram-positive","bacteria","."),4292536). assertion_content_comment('tOboGo_MaltoseTransport',s("The","directed","movement","of","maltose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Maltose","is","the","disaccharide","4-O-alpha-D-glucopyranosyl-D-glucopyranose",",","an","intermediate","in","the","catabolism","of","glycogen","and","starch","."),4291182). assertion_content_comment('tOboGo_MammaryDuctTerminalEndBudGrowth',s("The","morphogenetic","growth","of","the","large",",","club-shaped","terminal","end","of","a","mammary","gland","duct","during","prepubertal","growth","and","during","puberty","."),4111060). assertion_content_comment('tOboGo_MammaryGlandAlveolusDevelopment',s("The","progression","of","the","mammary","gland","alveolus","over","time",",","from","its","formation","to","its","mature","state",".","The","mammary","gland","alveolus","is","a","sac-like","structure","that","is","found","in","the","mature","gland","."),4110570). assertion_content_comment('tOboGo_MammaryGlandBranchingInvolvedInPregnancy',s("The","process","in","which","the","branching","structure","of","the","mammary","gland","duct","is","generated","and","organized","as","a","part","of","pregnancy","."),4110538). assertion_content_comment('tOboGo_MammaryGlandBranchingInvolvedInThelarche',s("The","process","in","which","the","branching","structure","of","the","mammary","gland","duct","is","generated","and","organized","during","the","period","of","sexual","maturity","in","mammals",".","The","mammary","gland","is","a","large","compound","sebaceous","gland","that","in","female","mammals","is","modified","to","secrete","milk","."),4110581). assertion_content_comment('tOboGo_MammaryGlandBudElongation',s("The","process","in","which","the","mammary","gland","bud","grows","along","its","axis","."),4111991). assertion_content_comment('tOboGo_MammaryGlandBudFormation',s("The","morphogenetic","process","in","which","a","bud","forms","from","the","mammary","placode",".","A","mammary","bud","is","bulb","of","epithelial","cells","that","is","distinct","from","the","surrounding","epidermis","."),4111929). assertion_content_comment('tOboGo_MammaryGlandBudMorphogenesis',s("The","process","in","which","anatomical","structures","of","the","mammary","gland","buds","are","generated","and","organized",".","Mammary","gland","buds","form","by","an","outpocketing","of","the","mammary","placodes","and","grow","to","invade","the","mammary","fat",",","when","they","form","the","mammary","cord","."),4111918). assertion_content_comment('tOboGo_MammaryGlandCordElongation',s("The","process","in","which","the","mammary","gland","sprout","grows","along","its","axis","."),4111952). assertion_content_comment('tOboGo_MammaryGlandCordFormation',s("The","process","in","which","the","mammary","gland","cord","forms","by","elongation","of","the","mammary","bud",".","The","cord","is","formed","once","the","elongating","bud","breaks","through","the","mesenchyme","and","reaches","the","fat","pad","."),4111898). assertion_content_comment('tOboGo_MammaryGlandCordMorphogenesis',s("The","process","in","which","anatomical","structures","of","the","mammary","gland","cord","are","generated","and","organized",".","Mammary","gland","cords","form","when","the","mammary","gland","bud","invades","the","mammary","fat","."),4111887). assertion_content_comment('tOboGo_MammaryGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mammary","gland","over","time",",","from","its","formation","to","the","mature","structure",".","The","mammary","gland","is","a","large","compound","sebaceous","gland","that","in","female","mammals","is","modified","to","secrete","milk",".","Its","development","starts","with","the","formation","of","the","mammary","line","and","ends","as","the","mature","gland","cycles","between","nursing","and","weaning","stages","."),3993247). assertion_content_comment('tOboGo_MammaryGlandDuctCavitation',s("Creation","of","the","central","hole","of","the","mammary","gland","duct","by","the","hollowing","out","of","a","solid","rod","."),4111817). assertion_content_comment('tOboGo_MammaryGlandDuctMorphogenesis',s("The","process","in","which","anatomical","structures","of","the","mammary","ducts","are","generated","and","organized",".","Mammary","ducts","are","epithelial","tubes","that","transport","milk","."),4110493). assertion_content_comment('tOboGo_MammaryGlandDuctRegressionInMales',s("The","process","in","which","the","epithelium","of","the","mammary","duct","is","destroyed","in","males","."),4112127). assertion_content_comment('tOboGo_MammaryGlandEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","epithelial","cell","becomes","a","more","specialized","epithelial","cell","of","the","mammary","gland","."),4112022). assertion_content_comment('tOboGo_MammaryGlandEpithelialCellProliferation',s("The","multiplication","or","reproduction","of","mammary","gland","epithelial","cells",",","resulting","in","the","expansion","of","a","cell","population",".","Mammary","gland","epithelial","cells","make","up","the","covering","of","surfaces","of","the","mammary","gland",".","The","mammary","gland","is","a","large","compound","sebaceous","gland","that","in","female","mammals","is","modified","to","secrete","milk","."),4063418). assertion_content_comment('tOboGo_MammaryGlandEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mammary","gland","epithelium","over","time",",","from","its","formation","to","the","mature","structure",".","The","mammary","gland","is","a","large","compound","sebaceous","gland","that","in","female","mammals","is","modified","to","secrete","milk","."),4063415). assertion_content_comment('tOboGo_MammaryGlandFatDevelopment',s("The","progression","of","the","mammary","gland","fat","over","time",",","from","its","formation","to","the","mature","structure",".","The","mammary","fat","is","an","adipose","structure","in","the","gland","that","is","invaded","by","the","mammary","ducts","."),4111786). assertion_content_comment('tOboGo_MammaryGlandFormation',s("The","process","pertaining","to","the","initial","formation","of","the","mammary","gland","from","unspecified","parts",".","The","process","begins","with","formation","of","the","mammary","line","and","ends","when","the","solid","mammary","bud","invades","the","primary","mammary","mesenchyme","."),4111836). assertion_content_comment('tOboGo_MammaryGlandInvolution',s("The","tissue","remodeling","that","removes","differentiated","mammary","epithelia","during","weaning","."),4109268). assertion_content_comment('tOboGo_MammaryGlandLobuleDevelopment',s("The","progression","of","the","mammary","gland","lobule","over","time",",","from","its","formation","to","the","mature","structure",".","A","mammary","gland","lobule","is","a","small","rounded","projection","of","the","mammary","gland","."),4110560). assertion_content_comment('tOboGo_MammaryGlandMorphogenesis',s("The","process","in","which","anatomical","structures","of","the","mammary","gland","are","generated","and","organized",".","Morphogenesis","refers","to","the","creation","of","shape",".","The","mammary","gland","is","a","large","compound","sebaceous","gland","that","in","female","mammals","is","modified","to","secrete","milk","."),4109266). assertion_content_comment('tOboGo_MammaryGlandSpecification',s("The","regionalization","process","in","which","the","mammary","line","is","specified",".","The","mammary","line","is","a","ridge","of","epidermal","cells","that","will","form","the","mammary","placodes","."),4116972). assertion_content_comment('tOboGo_MammaryPlacodeFormation',s("The","developmental","process","in","which","the","mammary","placode","forms",".","The","mammary","placode","is","a","transient","lens","shaped","structure","that","will","give","rise","to","the","mammary","bud","proper","."),4111842). assertion_content_comment('tOboGo_MammaryStemCellProliferation',s("The","expansion","of","a","mammary","stem","cell","population","by","cell","division",".","Mammary","stem","cells","are","a","source","of","cells","for","growth","of","the","mammary","gland","during","puberty","and","gestation",".","These","cells","can","give","rise","to","both","the","luminal","and","myoepithelial","cell","types","of","the","gland",",","and","can","regenerate","the","entire","organ","."),3993257). assertion_content_comment('tOboGo_MammillaryAxonalComplexDevelopment',s("The","progression","of","the","mammillary","axonal","complex","over","time",",","from","its","formation","to","the","mature","structure",".","The","mammillary","axonal","complex","is","formed","by","the","axons","from","the","lateral",",","medial","mammillary","and","the","dorsal","premammillary","nuclei","which","share","a","branching","pattern",".","Every","neuron","gives","off","one","axonal","stem","that","bifurcates","into","2","branches",".","One","of","the","branches","is","directed","dorsally","to","the","thalamus","and","another","caudally","to","the","midbrain","."),4133521). assertion_content_comment('tOboGo_MammillaryBodyDevelopment',s("The","progression","of","the","mammillary","body","over","time","from","its","initial","formation","until","its","mature","state",".","The","mammillary","body","is","a","protrusion","at","the","posterior","end","of","the","hypothalamus","that","contains","hypothalamic","nuclei","."),4049306). assertion_content_comment('tOboGo_MammillotectalAxonalTractDevelopment',s("The","progression","of","the","mammillotectal","tract","over","time",",","from","its","formation","to","the","mature","structure",".","The","mammillotectal","tract","is","the","collection","of","axons","that","connects","the","ventral","diencephalon","to","the","superior","colliculus","."),4133541). assertion_content_comment('tOboGo_MammillotegmentalAxonalTractDevelopment',s("The","process","in","which","the","mammillotegmental","tract","progresses","over","time",",","from","its","formation","to","the","mature","structure",".","The","mammillotegmental","tract","is","the","collection","of","axons","that","connects","the","ventral","diencephalon","to","the","tegmentum","and","pons","."),4133531). assertion_content_comment('tOboGo_MammillothalamicAxonalTractDevelopment',s("The","progression","of","the","mammillothalamic","axonal","tract",",","from","its","formation","to","the","mature","structure",".","The","mammillothalamic","tract","is","the","collection","of","axons","that","connects","the","two","major","subdivisions","of","the","diencephalon","(","hypothalamus","and","thalamus",")","and","closes","the","diencephalic","circuit","."),4133551). assertion_content_comment('tOboGo_Manchette',s("A","conical","shaped","array","of","microtubules","that","completely","covers","the","nucleus","of","a","spermatid",",","thought","to","be","involved","in","sperm","head","elongation","."),3993238). assertion_content_comment('tOboGo_MandelamideAmidaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-mandelamide","+","H","(","2",")","O","=","(","R",")","-mandelate","+","NH","(","4",")","(","+",")"),4268591). assertion_content_comment('tOboGo_MandelateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mandelate",",","the","anion","of","mandelic","acid",".","Mandelic","acid","(","alpha-hydroxybenzeneacetic","acid",")","is","an","8-carbon","alpha-hydroxy","acid","(","AHA",")","that","is","used","in","organic","chemistry","and","as","a","urinary","antiseptic","."),4354128). assertion_content_comment('tOboGo_MandelateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mandelate",",","the","anion","of","mandelic","acid",".","Mandelic","acid","(","alpha-hydroxybenzeneacetic","acid",")","is","an","8-carbon","alpha-hydroxy","acid","(","AHA",")","that","is","used","in","organic","chemistry","and","as","a","urinary","antiseptic","."),4243316). assertion_content_comment('tOboGo_MandelateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mandelate",",","the","anion","of","mandelic","acid",".","Mandelic","acid","(","alpha-hydroxybenzeneacetic","acid",")","is","an","8-carbon","alpha-hydroxy","acid","(","AHA",")","that","is","used","in","organic","chemistry","and","as","a","urinary","antiseptic","."),4243310). assertion_content_comment('tOboGo_MandelateRacemaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-mandelate","=","(","R",")","-mandelate","."),4273503). assertion_content_comment('tOboGo_MandelonitrileLyaseActivity',s("Catalysis","of","the","reaction",":","mandelonitrile","=","cyanide","+","benzaldehyde","."),4358716). assertion_content_comment('tOboGo_Manganese_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Mn2","+","(","in",")","+","H","+","(","out",")","=","Mn2","+","(","out",")","+","H","+","(","in",")"),4332840). assertion_content_comment('tOboGo_ManganeseIonBinding',s("Interacting","selectively","and","non-covalently","with","manganese","(","Mn",")","ions","."),4311136). assertion_content_comment('tOboGo_ManganeseIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","manganese","ions","within","an","organism","or","cell","."),4222111). assertion_content_comment('tOboGo_ManganeseIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","manganese","(","Mn",")","ions","from","one","side","of","a","membrane","to","the","other","."),4216777). assertion_content_comment('tOboGo_ManganeseIonTransmembraneTransport',s("A","process","in","which","a","manganese","ion","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4164207). assertion_content_comment('tOboGo_ManganeseIonTransport',s("The","directed","movement","of","manganese","(","Mn",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4164204). assertion_content_comment('tOboGo_ManganesePeroxidaseActivity',s("Catalysis","of","the","reaction",":","2","Mn2","+","+","2","H","+","+","hydrogen","peroxide","=","2","Mn3","+","+","2","H2O","."),4306052). assertion_content_comment('tOboGo_ManganeseResistancePermeaseActivity',"OBSOLETE.",4297529). assertion_content_comment('tOboGo_MannanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mannan",",","the","main","hemicellulose","of","soft","(","coniferous",")","wood",",","made","up","of","D-mannose",",","D-glucose","and","D-galactose","."),4287019). assertion_content_comment('tOboGo_MannanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mannan",",","the","main","hemicellulose","of","soft","(","coniferous",")","wood",",","made","up","of","D-mannose",",","D-glucose","and","D-galactose","."),4285557). assertion_content_comment('tOboGo_MannanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mannan",",","a","group","of","polysaccharides","containing","a","backbone","composed","of","a","polymer","of","D-mannose","units","."),4183803). assertion_content_comment('tOboGo_MannanSynthaseActivity',s("Catalysis","of","the","reaction",":","mannan","(","n",")","+","GDP-mannose","=","mannan","(","n","+","1",")","+","GDP",".","This","reaction","is","the","formation","of","the","beta-1",",","4-linked","mannan","backbone","in","substrates","such","as","galactomannan","."),4280033). assertion_content_comment('tOboGo_MannitolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mannitol",",","the","alditol","derived","from","D-mannose","by","reduction","of","the","aldehyde","group","."),4243422). assertion_content_comment('tOboGo_MannitolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mannitol",",","the","alditol","derived","from","D-mannose","by","reduction","of","the","aldehyde","group","."),4243437). assertion_content_comment('tOboGo_MannitolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","D-mannitol","+","NAD","(","+",")","=","D-mannose","+","H","(","+",")","+","NADH","."),4348083). assertion_content_comment('tOboGo_MannitolDehydrogenaseCytochromeActivity',s("Catalysis","of","the","reaction",":","D-mannitol","+","ferricytochrome","c","=","D-fructose","+","ferrocytochrome","c","."),4270545). assertion_content_comment('tOboGo_MannitolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mannitol",",","the","alditol","derived","from","D-mannose","by","reduction","of","the","aldehyde","group","."),4243419). assertion_content_comment('tOboGo_MannitolTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","mannitol","from","one","side","of","the","membrane","to","the","other",".","Mannitol","is","the","alditol","derived","from","D-mannose","by","reduction","of","the","aldehyde","group","."),4293511). assertion_content_comment('tOboGo_MannitolTransport',s("The","directed","movement","of","mannitol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Mannitol","is","the","alditol","derived","from","D-mannose","by","reduction","of","the","aldehyde","group","."),4290982). assertion_content_comment('tOboGo_MannokinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","D-mannose","=","ADP","+","D-mannose","6-phosphate","."),4237572). assertion_content_comment('tOboGo_MannonateDehydrataseActivity',s("Catalysis","of","the","reaction",":","D-mannonate","=","2-dehydro-3-deoxy-D-gluconate","+","H","(","2",")","O","."),4248652). assertion_content_comment('tOboGo_MannoproteinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mannoproteins",",","any","protein","that","contains","covalently","bound","mannose","residues","."),4224782). assertion_content_comment('tOboGo_MannoproteinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mannoproteins",",","any","protein","that","contains","covalently","bound","mannose","residues","."),4224811). assertion_content_comment('tOboGo_MannoproteinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mannoproteins",",","any","protein","that","contains","covalently","bound","mannose","residues","."),4224778). assertion_content_comment('tOboGo_MannosamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mannosomine",",","2-amino-2-deoxymannose",";","the","D-isomer","is","a","constituent","of","neuraminic","acids","as","well","as","mucolipids","and","mucoproteins","."),4224693). assertion_content_comment('tOboGo_MannosamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mannosomine",",","2-amino-2-deoxymannose",";","the","D-isomer","is","a","constituent","of","neuraminic","acids","as","well","as","mucolipids","and","mucoproteins","."),4224665). assertion_content_comment('tOboGo_MannosamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mannosomine",",","2-amino-2-deoxymannose",";","the","D-isomer","is","a","constituent","of","neuraminic","acids","as","well","as","mucolipids","and","mucoproteins","."),4224649). assertion_content_comment('tOboGo_MannoseBindingLectin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218831). assertion_content_comment('tOboGo_MannoseBinding',s("Interacting","selectively","and","non-covalently","with","mannose",",","a","monosaccharide","hexose",",","stereoisomeric","with","glucose",",","that","occurs","naturally","only","in","polymerized","forms","called","mannans","."),4218808). assertion_content_comment('tOboGo_MannoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mannose",",","the","aldohexose","manno-hexose",",","the","C-2","epimer","of","glucose","."),4239076). assertion_content_comment('tOboGo_MannoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mannose",",","the","aldohexose","manno-hexose",",","the","C-2","epimer","of","glucose","."),4239053). assertion_content_comment('tOboGo_Mannose_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","mannose","+","H","+","=","mannose","+","H","+"),4221893). assertion_content_comment('tOboGo_MannoseIsomeraseActivity',s("Catalysis","of","the","reaction",":","D-mannose","=","D-fructose","."),4270517). assertion_content_comment('tOboGo_MannoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mannose",",","the","aldohexose","manno-hexose",",","the","C-2","epimer","of","glucose",".","The","D-","(","+",")","-form","is","widely","distributed","in","mannans","and","hemicelluloses","and","is","of","major","importance","in","the","core","oligosaccharide","of","N-linked","oligosaccharides","of","glycoproteins","."),4225228). assertion_content_comment('tOboGo_MannoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","mannose","from","one","side","of","the","membrane","to","the","other",".","Mannose","is","the","aldohexose","manno-hexose",",","the","C-2","epimer","of","glucose",".","The","D-","(","+",")","-form","is","widely","distributed","in","mannans","and","hemicelluloses","and","is","of","major","importance","in","the","core","oligosaccharide","of","N-linked","oligosaccharides","of","glycoproteins","."),4221890). assertion_content_comment('tOboGo_MannoseTransport',s("The","directed","movement","of","mannose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Mannose","is","the","aldohexose","manno-hexose",",","the","C-2","epimer","of","glucose",".","The","D-","(","+",")","-form","is","widely","distributed","in","mannans","and","hemicelluloses","and","is","of","major","importance","in","the","core","oligosaccharide","of","N-linked","oligosaccharides","of","glycoproteins","."),4291131). assertion_content_comment('tOboGo_MannosidaseActivity',s("Catalysis","of","the","hydrolysis","of","mannosyl","compounds",",","substances","containing","a","group","derived","from","a","cyclic","form","of","mannose","or","a","mannose","derivative","."),4204455). assertion_content_comment('tOboGo_Mannosome',s("A","specialised","tubular","organelle",",","assembled","in","hexagonal","bundles","within","an","external","membrane",".","Mannosomes","are","specific","to","molluscs","and","are","thought","to","be","involved","in","a","general","stress","reaction","."),4316808). assertion_content_comment('tOboGo_MannosylDiphosphorylinositolCeramideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mannosyl","diphosphorylinositol","ceramide",",","any","lipid","with","a","phosphodiester","bridge","between","an","inositol","residue","and","the","ceramide","group","which","contains","two","phosphoryl","(","-P","(","O",")","=",")","groups","and","a","mannose","derivative","."),4230724). assertion_content_comment('tOboGo_MannosylglycerateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mannosylglycerate",",","a","very","common","compatible","solute","in","thermophilic","and","hyperthermophilic","organisms","."),4286419). assertion_content_comment('tOboGo_MannosylglycerateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mannosylglycerate",",","a","very","common","compatible","solute","in","thermophilic","and","hyperthermophilic","organisms","."),4286416). assertion_content_comment('tOboGo_MannosylglycerateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","mannosylglycerate","from","one","side","of","the","membrane","to","the","other","."),4286432). assertion_content_comment('tOboGo_MannosylglycerateTransport',s("The","directed","movement","of","mannosylglycerate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4286441). assertion_content_comment('tOboGo_MannosylphosphateTransferaseActivity',s("Catalysis","of","the","transfer","of","a","mannosylphosphate","group","from","one","compound","to","another","."),4345561). assertion_content_comment('tOboGo_MannosyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","mannosyl","group","to","an","acceptor","molecule",",","typically","another","carbohydrate","or","a","lipid","."),4204147). assertion_content_comment('tOboGo_MannosyltransferaseComplex',s("A","complex","that","posseses","mannosyltransferase","activity","."),3971964). assertion_content_comment('tOboGo_MannuronateReductaseActivity',s("Catalysis","of","the","reaction",":","D-mannonate","+","NAD","(","P",")","+","=","D-mannuronate","+","NAD","(","P",")","H","+","H","+"),4270730). assertion_content_comment('tOboGo_MAPERKKinaseKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","mitogen","activated","protein","kinase","kinase","=","ADP","+","mitogen","activated","protein","kinase","kinase","phosphate","."),4200585). assertion_content_comment('tOboGo_MAPKExportFromNucleus',s("The","directed","movement","of","a","MAP","kinase","from","the","nucleus","to","the","cytoplasm","."),4129308). assertion_content_comment('tOboGo_MAPKImportIntoNucleusInvolvedInCellWallBiogenesis',s("The","directed","movement","of","a","MAP","kinase","to","the","nucleus","that","occurs","in","the","context","of","cell","wall","biogenesis",",","the","assembly","and","arrangement","of","the","cell","wall",",","the","rigid","or","semi-rigid","envelope","lying","outside","the","cell","membrane","of","plant",",","fungal","and","most","prokaryotic","cells","."),3973074). assertion_content_comment('tOboGo_MAPKImportIntoNucleusInvolvedInConjugationWithCellularFusion',s("The","directed","movement","of","a","MAP","kinase","to","the","nucleus","that","occurs","in","the","context","of","conjugation","with","cellular","fusion","."),4129618). assertion_content_comment('tOboGo_MAPKImportIntoNucleusInvolvedInInnateImmuneResponse',s("The","directed","movement","of","a","MAP","kinase","to","the","nucleus","in","the","context","of","an","innate","immune","response",",","a","defense","response","mediated","by","germline","encoded","components","that","directly","recognize","components","of","potential","pathogens","."),4083011). assertion_content_comment('tOboGo_MAPKImportIntoNucleusInvolvedInOsmosensorySignalingPathway',s("The","directed","movement","of","a","MAP","kinase","to","the","nucleus","during","osmolarity","sensing","."),3972980). assertion_content_comment('tOboGo_MAPKImportIntoNucleus',s("The","directed","movement","of","a","MAP","kinase","to","the","nucleus","upon","activation","."),3972920). assertion_content_comment('tOboGo_MAPKinaseActivity',s("Catalysis","of","the","reaction",":","protein","+","ATP","=","protein","phosphate","+","ADP",".","This","reaction","is","the","phosphorylation","of","proteins",".","Mitogen-activated","protein","kinase",";","a","family","of","protein","kinases","that","perform","a","crucial","step","in","relaying","signals","from","the","plasma","membrane","to","the","nucleus",".","They","are","activated","by","a","wide","range","of","proliferation-","or","differentiation-inducing","signals",";","activation","is","strong","with","agonists","such","as","polypeptide","growth","factors","and","tumor-promoting","phorbol","esters",",","but","weak","(","in","most","cell","backgrounds",")","by","stress","stimuli","."),4200637). assertion_content_comment('tOboGo_MAPKinaseKinaseActivity',s("Catalysis","of","the","concomitant","phosphorylation","of","threonine","(","T",")","and","tyrosine","(","Y",")","residues","in","a","Thr-Glu-Tyr","(","TEY",")","thiolester","sequence","in","MAP","kinases",".","It","is","a","dual-specificity","mitogen-activated","protein","kinase","kinase","and","requires","activation","by","the","serine/threonine","kinase",",","MAP","kinase","kinase","kinase","."),4200595). assertion_content_comment('tOboGo_MAPKinaseKinaseKinaseActivity',s("Catalysis","of","the","phosphorylation","and","activation","of","MAP","kinase","kinases",";","each","MAP","kinase","kinase","can","be","phosphorylated","by","any","of","several","MAP","kinase","kinase","kinases","."),4200565). assertion_content_comment('tOboGo_MAPKinaseKinaseKinaseKinaseActivity',s("Catalysis","of","the","phosphorylation","of","serine","and","threonine","residues","in","a","mitogen-activated","protein","kinase","kinase","kinase","(","MAPKKK",")",",","resulting","in","activation","of","MAPKKK",".","MAPKKK","signaling","pathways","relay",",","amplify","and","integrate","signals","from","the","plasma","membrane","to","the","nucleus","in","response","to","a","diverse","range","of","extracellular","stimuli","."),4255160). assertion_content_comment('tOboGo_MAPKinasePhosphataseActivity',s("Catalysis","of","the","reaction",":","a","phosphorylated","MAP","kinase","+","H2O","=","a","MAP","kinase","+","phosphate","."),4268998). assertion_content_comment('tOboGo_MAPKinaseTyrosinePhosphataseActivity',s("Catalysis","of","the","reaction",":","MAP","kinase","tyrosine","phosphate","+","H2O","=","MAP","kinase","tyrosine","+","phosphate","."),4341017). assertion_content_comment('tOboGo_MAPKinaseTyrosineSerineThreoninePhosphataseActivity',s("Catalysis","of","the","reaction",":","MAP","kinase","serine/threonine/tyrosine","phosphate","+","H2O","=","MAP","kinase","serine/threonine/tyrosine","+","phosphate","."),4269000). assertion_content_comment('tOboGo_MAPKKKCascadeDuringSporulationSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310052). assertion_content_comment('tOboGo_MAPKKKCascadeDuringSporulationSensuSaccharomyces',s("OBSOLETE",".","MAPKKK","cascade","involved","in","transduction","of","signal","promoting","sporulation",".","As","in",",","but","not","restricted","to",",","the","taxon","Saccharomyces","(","Saccharomyces",",","ncbi_taxonomy_id",":","4930",")"),4346567). assertion_content_comment('tOboGo_MAPKKKCascadeInvolvedInCellWallBiogenesis',s("A","MAPKKK","cascade","culminating","in","the","phosphorylation","and","activation","of","a","MAP","kinase","that","occurs","in","the","context","of","cell","wall","biogenesis",",","the","assembly","and","arrangement","of","the","cell","wall",",","the","rigid","or","semi-rigid","envelope","lying","outside","the","cell","membrane","of","plant",",","fungal","and","most","prokaryotic","cells","."),3972969). assertion_content_comment('tOboGo_MAPKKKCascadeInvolvedInConjugationWithCellularFusion',s("A","MAPKKK","cascade","culminating","in","the","phosphorylation","and","activation","of","a","MAP","kinase","that","occurs","in","the","context","of","conjugation","with","cellular","fusion","."),4129592). assertion_content_comment('tOboGo_MAPKKKCascadeInvolvedInEpidermalGrowthFactorReceptorSignaling',s("The","process","in","which","a","signal","is","passed","from","the","epidermal","growth","factor","receptor","(","EGFR",")","to","components","of","the","MAPKKK","cascade",",","which","become","activated","themselves","to","further","propagate","the","signal","and","finally","trigger","a","change","in","the","function","or","state","of","the","cell","."),4082235). assertion_content_comment('tOboGo_MAPKKKCascadeInvolvedInInnateImmuneResponse',s("A","MAPKKK","cascade","culminating","in","the","phosphorylation","and","activation","of","a","MAP","kinase","that","occurs","in","the","context","of","an","innate","immune","response",",","a","defense","response","mediated","by","germline","encoded","components","that","directly","recognize","components","of","potential","pathogens","."),4082967). assertion_content_comment('tOboGo_MAPKKKCascadeInvolvedInOsmosensorySignalingPathway',s("MAPKKK","cascade","involved","in","signal","transduction","in","response","to","change","in","osmotic","conditions","."),3972186). assertion_content_comment('tOboGo_MAPKKKCascadeMatingSensuFungi',s("OBSOLETE",".","MAPKKK","cascade","involved","in","transducing","mating","pheromone","signal","in","a","fungus","."),4310406). assertion_content_comment('tOboGo_MAPKKKCascadeMatingSensuSaccharomyces',s("OBSOLETE",".","MAPKKK","cascade","involved","in","transduction","of","mating","pheromone","signal",",","as","described","in","Saccharomyces","."),4235567). assertion_content_comment('tOboGo_MAPKKKCascadePseudohyphalGrowth',s("OBSOLETE",".","MAPKKK","cascade","involved","in","transduction","of","signal","promoting","pseudohyphal","or","invasive","growth","."),4345986). assertion_content_comment('tOboGo_MAPKKKCascade',s("A","cascade","of","at","least","three","protein","kinase","activities","culminating","in","the","phosphorylation","and","activation","of","a","MAP","kinase",".","MAPKKK","cascades","lie","downstream","of","numerous","signaling","pathways","."),3972176). assertion_content_comment('tOboGo_MAPKPhosphataseExportFromNucleusLeptomycinBSensitive',s("Leptomycin","B-sensitive","movement","of","a","MAPK","phosphatase","from","the","nucleus","to","the","cytoplasm","."),4299027). assertion_content_comment('tOboGo_MAPKPhosphataseExportFromNucleus',s("The","directed","movement","of","a","MAPK","phosphatase","from","the","nucleus","to","the","cytoplasm","."),4299021). assertion_content_comment('tOboGo_MAPKPhosphataseTransporterActivity',s("OBSOLETE",".","Enables","the","directed","movement","of","MAPK","phosphatase","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4299002). assertion_content_comment('tOboGo_MAPKTransporterActivity',s("OBSOLETE",".","Enables","the","directed","movement","of","MAP","kinase","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4299044). assertion_content_comment('tOboGo_MarginalZoneBCellDifferentiation',s("The","process","in","which","a","B","cell","in","the","spleen","acquires","the","specialized","features","of","a","marginal","zone","B","cell",".","Marginal","zone","B","cells","are","localized","in","a","distinct","anatomical","region","of","the","spleen","that","represents","the","major","antigen-filtering","and","scavenging","area","(","by","specialized","macrophages","resident","there",")","It","appears","that","they","are","preselected","to","express","a","BCR","repertoire","similar","to","B-1","B","cells",",","biased","toward","bacterial","cell","wall","constituents","and","senescent","self-components","(","such","as","oxidized","LDL",")"),4380481). assertion_content_comment('tOboGo_MarneralSynthaseActivity',s("Catalysis","of","the","reaction",":","oxidosqualene","=","marneral","."),4361216). assertion_content_comment('tOboGo_MasculinizationOfHermaphroditeSoma',s("Promotion","of","male","sex","and","sexual","phenotypes","in","the","hermaphroditic","nematode","soma",".","An","example","of","this","is","found","in","Caenorhabditis","elegans","."),4306118). assertion_content_comment('tOboGo_MastCellActivationInvolvedInImmuneResponse',s("The","change","in","morphology","and","behavior","of","a","mast","cell","resulting","from","exposure","to","a","cytokine",",","chemokine",",","soluble","factor",",","or","to","(","at","least","in","mammals",")","an","antigen","which","the","mast","cell","has","specifically","bound","via","IgE","bound","to","Fc-epsilonRI","receptors",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),3996352). assertion_content_comment('tOboGo_MastCellActivation',s("The","change","in","morphology","and","behavior","of","a","mast","cell","resulting","from","exposure","to","a","cytokine",",","chemokine",",","soluble","factor",",","or","to","(","at","least","in","mammals",")","an","antigen","which","the","mast","cell","has","specifically","bound","via","IgE","bound","to","Fc-epsilonRI","receptors","."),3996350). assertion_content_comment('tOboGo_MastCellApoptosis',s("The","process","of","apoptosis","in","mast","cells","."),4065101). assertion_content_comment('tOboGo_MastCellChemotaxis',s("The","movement","of","a","mast","cell","in","response","to","an","external","stimulus","."),4110441). assertion_content_comment('tOboGo_MastCellCytokineProduction',s("Any","process","that","contributes","to","cytokine","production","by","a","mast","cell","."),4068946). assertion_content_comment('tOboGo_MastCellDegranulation',s("The","regulated","exocytosis","of","secretory","granules","containing","preformed","mediators","such","as","histamine",",","serotonin",",","and","neutral","proteases","by","a","mast","cell","."),3996390). assertion_content_comment('tOboGo_MastCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","myeloid","precursor","cell","acquires","the","specialized","features","of","a","mast","cell",".","A","mast","cell","is","a","cell","that","is","found","in","almost","all","tissues","containing","numerous","basophilic","granules","and","capable","of","releasing","large","amounts","of","histamine","and","heparin","upon","activation","."),4114956). assertion_content_comment('tOboGo_MastCellGranule',s("Coarse",",","bluish-black","staining","cytoplasmic","granules",",","bounded","by","a","plasma","membrane","and","found","in","mast","cells","and","basophils",".","Contents","include","histamine",",","heparin",",","chondroitin","sulfates",",","chymase","and","tryptase","."),4316449). assertion_content_comment('tOboGo_MastCellHomeostasis',s("The","process","of","regulating","the","proliferation","and","elimination","of","mast","cells","such","that","the","total","number","of","mast","cells","within","a","whole","or","part","of","an","organism","is","stable","over","time","in","the","absence","of","an","outside","stimulus","."),4065099). assertion_content_comment('tOboGo_MastCellMediatedImmunity',s("Any","process","involved","in","the","carrying","out","of","an","immune","response","by","a","mast","cell","."),3996388). assertion_content_comment('tOboGo_MastCellProliferation',s("The","expansion","of","a","mast","cell","population","by","cell","division","."),4130447). assertion_content_comment('tOboGo_MastCellSecretoryGranuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","secretory","granule","in","a","mast","cell",".","A","secretory","granule","is","a","small","subcellular","vesicle",",","surrounded","by","a","membrane",",","that","is","formed","from","the","Golgi","apparatus","and","contains","a","highly","concentrated","protein","destined","for","secretion","."),4063234). assertion_content_comment('tOboGo_Mastication',s("The","process","of","biting","and","mashing","food","with","the","teeth","prior","to","swallowing","."),4172834). assertion_content_comment('tOboGo_MaternalAggressiveBehavior',s("Aggressive","behavior","of","a","female","to","protect","her","offspring","from","a","threat","."),4375578). assertion_content_comment('tOboGo_MaternalBehavior',s("Female","behaviors","associated","with","the","care","and","rearing","of","offspring","."),4316971). assertion_content_comment('tOboGo_MaternalDeterminationOfAnteriorPosteriorAxisEmbryo',s("The","specification","of","the","anterior/posterior","axis","of","the","embryo","by","gradients","of","maternally-transcribed","gene","products",";","exemplified","in","insects","by","the","morphogens",",","bicoid","and","nanos","."),4018952). assertion_content_comment('tOboGo_MaternalDeterminationOfDorsalVentralAxisOvarianFollicularEpitheliumSomaEncoded',s("Polarization","of","the","ovarian","follicle","cells","along","the","dorsal-ventral","axis","by","a","gene","product","encoded","by","somatic","cells",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4247195). assertion_content_comment('tOboGo_MaternalPlacentaDevelopment',s("Maternally","driven","process","whose","specific","outcome","is","the","progression","of","the","placenta","over","time",",","from","its","formation","to","the","mature","structure",".","The","placenta","is","an","organ","of","metabolic","interchange","between","fetus","and","mother",",","partly","of","embryonic","origin","and","partly","of","maternal","origin","."),3986687). assertion_content_comment('tOboGo_MaternalProcessInvolvedInFemalePregnancy',s("A","reproductive","process","occurring","in","the","mother","that","allows","an","embryo","or","fetus","to","develop","within","it","."),4108060). assertion_content_comment('tOboGo_MaternalProcessInvolvedInParturition',s("A","reproductive","process","occurring","in","the","mother","that","results","in","birth","."),4108093). assertion_content_comment('tOboGo_MaternalSpecificationOfDorsalVentralAxisOocyteSomaEncoded',s("Polarization","of","the","oocyte","along","the","dorsal-ventral","axis",",","by","a","gene","product","encoded","by","somatic","cells",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4235824). assertion_content_comment('tOboGo_MatingBehaviorSexDiscrimination',s("The","actions","or","reactions","of","individuals","for","the","purpose","of","discriminating","between","the","sexes",",","for","the","purpose","of","finding","a","suitable","mating","partner","."),4384613). assertion_content_comment('tOboGo_MatingBehavior',s("The","behavioral","interactions","between","organisms","for","the","purpose","of","mating",",","or","sexual","reproduction","resulting","in","the","formation","of","zygotes","."),4014915). assertion_content_comment('tOboGo_MatingPheromoneActivity',s("The","activity","of","binding","to","and","activating","specific","cell","surface","receptors",",","thereby","inducing","a","behavioral","or","physiological","response","(","s",")","from","a","responding","organism","or","cell","that","leads","to","the","transfer","or","union","of","genetic","material","between","organisms","or","cells",".","The","mating","pheromone","can","either","be","retained","on","the","cell","surface","or","secreted","."),4363671). assertion_content_comment('tOboGo_MatingPheromoneExporter',s("OBSOLETE",".","Exports","diffusible","peptide","signals","that","are","responsible","for","binding","to","other","cells","and","triggering","a","series","of","responses","to","facilitate","mating","."),4313974). assertion_content_comment('tOboGo_MatingPheromoneSecretionInvolvedInConjugation',s("The","regulated","release","of","a","mating","pheromone",",","a","peptide","hormone","that","induces","a","behavioral","or","physiological","response","(","s",")","from","a","responding","organism","or","cell",",","that","contributes","to","the","union","or","introduction","of","genetic","information","from","compatible","mating","types","that","results","in","a","genetically","different","individual",".","Conjugation","requires","direct","cellular","contact","between","the","organisms","."),4125600). assertion_content_comment('tOboGo_MatingPheromoneSecretionInvolvedInConjugationWithCellularFusion',s("The","regulated","release","of","a","mating","pheromone",",","a","peptide","hormone","that","induces","a","behavioral","or","physiological","response","(","s",")","from","a","responding","organism","or","cell",",","that","contributes","to","a","conjugation","process","that","results","in","the","union","of","cellular","and","genetic","information","from","compatible","mating","types","."),4130265). assertion_content_comment('tOboGo_MatingPheromoneSecretion',s("The","regulated","release","of","a","mating","pheromone",",","a","peptide","hormone","that","induces","a","behavioral","or","physiological","response","(","s",")","from","a","responding","organism","or","cell",",","that","contributes","to","a","process","of","sexual","reproduction","."),4125596). assertion_content_comment('tOboGo_MatingPlugFormation',s("The","deposition","of","a","plug","of","sperm","or","other","gelatinous","material","into","the","opening","of","the","vulva","by","a","male","at","the","termination","of","copulation",".","Probably","acts","to","prevent","subsequent","matings","by","other","males","."),4077827). assertion_content_comment('tOboGo_MatingProjectionAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","cell","projection","in","response","to","mating","pheromone",".","This","process","is","observed","in","unicellular","fungi","."),4058539). assertion_content_comment('tOboGo_MatingProjectionBase',s("The","region","where","the","mating","projection","meets","the","bulk","of","the","cell",",","in","unicellular","fungi","exposed","to","mating","pheromone","."),3980308). assertion_content_comment('tOboGo_MatingProjectionMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","mating","projection",",","the","projection","formed","by","unicellular","fungi","in","response","to","mating","pheromone","."),4137137). assertion_content_comment('tOboGo_MatingProjectionSeptinBand',s("A","septin","band",",","i.e",".","a","diffuse","ring","composed","of","a","series","of","septin","bars","running","parallel","to","the","long","axis","of","the","cell",",","located","at","the","neck","of","a","shmoo","(","mating","projection",")"),4054858). assertion_content_comment('tOboGo_MatingProjectionSeptinRing',s("A","septin","ring",",","i.e",".","a","ring-shaped","structure","composed","of","septins","and","septin-associated","proteins",",","located","at","the","neck","of","a","shmoo","(","mating","projection",")","The","septin","ring","in","the","neck","of","a","shmoo","may","act","as","a","barrier","to","localize","mating","factors","in","the","shmoo","tip","."),4055277). assertion_content_comment('tOboGo_MatingProjection',s("The","projection","formed","by","unicellular","fungi","in","response","to","mating","pheromone","."),3980285). assertion_content_comment('tOboGo_MatingProjectionTipMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","mating","projection","tip","."),4132272). assertion_content_comment('tOboGo_MatingProjectionTipPolarisome',s("Protein","complex","that","has","a","role","in","determining","cell","polarity",",","found","at","the","tip","of","the","mating","projection","in","unicellular","fungi","exposed","to","mating","pheromone","."),4060420). assertion_content_comment('tOboGo_MatingProjectionTip',s("The","apex","of","the","mating","projection","in","unicellular","fungi","exposed","to","mating","pheromone",";","site","of","polarized","growth","."),4060407). assertion_content_comment('tOboGo_Mating',s("The","pairwise","union","of","individuals","for","the","purpose","of","sexual","reproduction",",","ultimately","resulting","in","the","formation","of","zygotes","."),4014913). assertion_content_comment('tOboGo_MatingTypeDetermination',s("Any","process","that","establishes","and","transmits","the","specification","of","mating","type","upon","an","individual",".","Mating","types","are","the","equivalent","in","microorganisms","of","the","sexes","in","higher","organisms","."),3978057). assertion_content_comment('tOboGo_MatingTypeSwitching',s("The","conversion","of","a","single-cell","organism","from","one","mating","type","to","another","by","the","precise","replacement","of","a","DNA","sequence","at","the","expressed","mating","type","locus","with","a","copy","of","a","sequence","from","a","donor","locus","."),3978060). assertion_content_comment('tOboGo_MatrilysinActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","Ala14-Leu15","and","Tyr16-Leu17","in","B","chain","of","insulin",".","No","action","on","collagen","types","I",",","II",",","IV","and","V",".","Cleaves","gelatin","chain","alpha-2","(","I",")","&","gt",";","alpha-1","(","I",")"),4209941). assertion_content_comment('tOboGo_MatrixMetalloproteinase19Activity',s("OBSOLETE",".","Was","not","defined","before","being","made","obsolete","."),4310210). assertion_content_comment('tOboGo_MatrixMetalloproteinase25Activity',s("OBSOLETE",".","Was","not","defined","before","being","made","obsolete","."),4310173). assertion_content_comment('tOboGo_MaturationOf2SRRNA',s("Any","process","involved","in","the","maturation","of","a","precursor","2S","ribosomal","RNA","(","rRNA",")","molecule","into","a","mature","2S","rRNA","molecule","."),3976366). assertion_content_comment('tOboGo_MaturationOf45SRRNA',s("Any","process","involved","in","the","maturation","of","a","precursor","4.5S","ribosomal","RNA","(","rRNA",")","molecule","into","a","mature","4.5S","rRNA","molecule","."),4362412). assertion_content_comment('tOboGo_MaturationOf58SRRNA',s("Any","process","involved","in","the","maturation","of","a","precursor","5.8S","ribosomal","RNA","(","rRNA",")","molecule","into","a","mature","5.8S","rRNA","molecule","."),3976121). assertion_content_comment('tOboGo_MaturationOf5SRRNA',s("Any","process","involved","in","the","maturation","of","a","precursor","5S","ribosomal","RNA","(","rRNA",")","molecule","into","a","mature","5S","rRNA","molecule","."),4362342). assertion_content_comment('tOboGo_MaturationOfAppressoriumOnOrNearHost',s("The","process","in","which","specialized","features","of","the","symbiont","appressorium","are","acquired","post","initiation",",","to","aid","in","infection","of","the","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146947). assertion_content_comment('tOboGo_MatureBCellApoptosis',s("The","process","of","apoptosis","in","mature","B","cells","."),3999479). assertion_content_comment('tOboGo_MatureBCellDifferentiationInvolvedInImmuneResponse',s("The","process","in","which","a","naive","B","cell","acquires","the","specialized","features","of","a","mature","or","memory","B","cell","during","an","immune","response","."),4379848). assertion_content_comment('tOboGo_MatureBCellDifferentiation',s("The","process","in","which","transitional","stage","B","cells","acquire","the","specialized","features","of","mature","B","cells","in","the","spleen","."),3989008). assertion_content_comment('tOboGo_MatureChylomicron',s("A","chylomicron","that","contains","apolipoprotein","C2","(","APOC2",")",",","a","cofactor","for","lipoprotein","lipase","(","LPL",")","activity",",","and","has","a","mean","diameter","of","500","nm","and","density","of","0.95g/ml",".","Mature","chylomicron","particles","transport","exogenous","(","dietary",")","lipids","from","the","intestines","to","other","body","tissues",",","via","the","blood","and","lymph","."),4355415). assertion_content_comment('tOboGo_MatureDendriticCellDifferentiation',s("The","process","in","which","antigen-activated","dendritic","cells","acquire","the","specialized","features","of","a","mature","dendritic","cell",".","Mature","dendritic","cells","upregulate","the","surface","expression","of","MHC","molecules",",","chemokine","receptors","and","adhesion","molecules",",","and","increase","the","number","of","dendrites","(","cytoplasmic","protrusions",")","in","preparation","for","migration","to","lymphoid","organs","where","they","present","antigen","to","T","cells","."),4074058). assertion_content_comment('tOboGo_MatureFollicleStage',s("The","stage","in","oogenesis","when","the","antrum","is","swollen","with","follicular","fluid",".","The","ovum","is","ready","to","erupt","from","the","ovary","and","is","arrested","at","metaphase","of","the","second","meiotic","division","."),4385091). assertion_content_comment('tOboGo_MatureNaturalKillerCellChemotaxis',s("The","directed","movement","of","a","mature","natural","killer","cell","guided","by","a","specific","chemical","concentration","gradient",".","Movement","may","be","towards","a","higher","concentration","(","positive","chemotaxis",")","or","towards","a","lower","concentration","(","negative","chemotaxis",")","A","mature","natural","killer","cell","is","a","natural","killer","cell","that","is","developmentally","mature","and","expresses","a","variety","of","inhibitory","and","activating","receptors","that","recognize","MHC","class","and","other","stress","related","molecules","."),4381092). assertion_content_comment('tOboGo_MatureRibosomeAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","the","large","and","small","ribosomal","subunits","into","a","functional","ribosome","."),4314645). assertion_content_comment('tOboGo_MaurerSCleft',s("A","disk-like","structure","that","appears","at","the","periphery","of","a","red","blood","cell","infected","by","an","apicomplexan","parasite",",","characterized","by","a","translucent","lumen","and","an","electron-dense","coat","of","variable","thickness",";","often","appears","to","be","tethered","to","the","host","cell","membrane","by","fibrous","connections","with","the","erythrocyte","cytoskeleton","."),4079764). assertion_content_comment('tOboGo_MBand',s("The","midline","of","aligned","thick","filaments","in","a","sarcomere",";","location","of","specific","proteins","that","link","thick","filaments",".","Depending","on","muscle","type","the","M","band","consists","of","different","numbers","of","M","lines","."),4058450). assertion_content_comment('tOboGo_MBFTranscriptionComplex',s("A","protein","complex","that","binds","to","the","Mlu1","cell","cycle","box","(","MCB",")","promoter","element",",","consensus","sequence","ACGCGN",",","and","is","involved","in","regulation","of","transcription","during","the","G1/S","transition","of","the","cell","cycle",".","In","Saccharomyces",",","the","complex","contains","a","heterodimer","of","the","DNA","binding","protein","Mbp1p","and","the","activator","Swi4p",",","and","is","associated","with","additional","proteins","known","as","Nrm1p",",","Msa1p",",","and","Msa2p",";","in","Schizosaccharomyces","the","complex","contains","Res1p",",","Res2p",",","and","Cdc10p","."),4307672). assertion_content_comment('tOboGo_MCMComplex',s("A","hexameric","protein","complex","required","for","the","initiation","and","regulation","of","DNA","replication","."),4316668). assertion_content_comment('tOboGo_MDM2Binding',s("Interacting","selectively","and","non-covalently","with","any","isoform","of","the","MDM2","protein",",","a","negative","regulator","of","p53","."),4173991). assertion_content_comment('tOboGo_MDM4Binding',s("Interacting","selectively","and","non-covalently","with","any","isoform","of","the","MDM4","protein",",","a","negative","regulator","of","p53","."),4174000). assertion_content_comment('tOboGo_MechanicallyGatedChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","solute","by","a","channel","that","opens","in","response","to","a","mechanical","stress","."),4255583). assertion_content_comment('tOboGo_MechanoreceptorDifferentiationInvolvedInMechanosensoryEpitheliumRegeneration',s("Differentiation","of","new","mechanoreceptors","to","replace","those","lost","or","destroyed","by","injury","."),4130516). assertion_content_comment('tOboGo_MechanoreceptorDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mechanoreceptor",",","a","cell","specialized","to","transduce","mechanical","stimuli","and","relay","that","information","centrally","in","the","nervous","system","."),3992788). assertion_content_comment('tOboGo_MechanosensoryBehavior',s("Behavior","that","is","dependent","upon","the","sensation","of","a","mechanical","stimulus","."),4235073). assertion_content_comment('tOboGo_MechanosensoryEpitheliumRegeneration',s("The","regrowth","of","lost","or","destroyed","mechanosensory","epithelia","."),4130506). assertion_content_comment('tOboGo_MechanosensoryLateralLineSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mechanosensory","lateral","line","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","mechanosensory","lateral","line","system","consists","of","small","sensory","patches","(","neuromasts",")","located","superficially","on","the","skin","or","just","under","the","skin","in","fluid-filled","canals","on","the","head","and","body","of","all","fishes","and","most","amphibians",".","The","neuromasts","are","innervated","by","several","lateral","line","nerves",",","which","project","primarily","to","the","hindbrain",".","The","mechanosensory","lateral","line","system","is","stimulated","by","local","water","displacements","and","vibrations",",","and","detects","propulsion","of","the","fish","through","the","water",",","as","well","as","facilitating","shoaling",",","prey","capture",",","and","predator","and","obstacle","avoidance","."),4082673). assertion_content_comment('tOboGo_MedialCortex',s("A","medial","cortical","band","overlaying","the","nucleus","which","acts","as","a","landmark","for","contractile","ring","positioning","and","plays","a","role","in","cell","cycle","regulation","."),4128422). assertion_content_comment('tOboGo_MedialCorticalNode',s("A","protein","complex","that","contains","the","mid1",",","cdr2",",","wee1",",","klp8",",","and","blt1","proteins",",","and","is","involved","in","contractile","ring","localization",".","Medial","cortical","node","complexes","appear","as","cortical","dots","in","the","middle","of","the","cell","during","interphase",",","and","function","to","recruit","other","ring","components","in","early","mitosis","."),4128435). assertion_content_comment('tOboGo_MedialFinDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","medial","fin","over","time",",","from","its","formation","to","the","mature","structure","."),4071711). assertion_content_comment('tOboGo_MedialFinMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","medial","fin","are","generated","and","organized",".","A","medial","fin","is","an","unpaired","fin","of","fish",",","usually","located","dorsomedially","or","ventromedially","and","primarily","used","for","stability","while","swimming","."),4071721). assertion_content_comment('tOboGo_MedialGanglionicEminenceCellProliferation',s("The","multiplication","or","reproduction","of","medial","ganglionic","eminence","cells",",","resulting","in","the","expansion","of","a","cell","population","."),4336750). assertion_content_comment('tOboGo_MedialMembraneBandAssembly',s("The","assembly","of","a","sterol-rich","region","of","the","plasma","membrane","at","the","cell","surface","overlying","the","contractile","ring","."),4055001). assertion_content_comment('tOboGo_MedialMembraneBand',s("A","sterol-rich","region","of","the","plasma","membrane","which","forms","at","the","cell","surface","overlying","the","contractile","ring","and","spreads","into","the","invaginating","plasma","membrane","surrounding","the","septum","."),4329517). assertion_content_comment('tOboGo_MedialMotorColumnNeuronDifferentiation',s("The","process","in","which","differentiating","motor","neurons","in","the","neural","tube","acquire","the","specialized","structural","and/or","functional","features","of","medial","motor","column","neurons",".","Medial","motor","column","neurons","are","generated","at","all","rostrocaudal","levels","and","send","axons","to","the","axial","muscles","(","medial","group",")","and","to","the","body","wall","muscles","(","lateral","group",")","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","."),4041341). assertion_content_comment('tOboGo_MediatorComplex',s("A","protein","complex","that","interacts","with","the","carboxy-terminal","domain","of","the","largest","subunit","of","RNA","polymerase","II","and","plays","an","active","role","in","transducing","the","signal","from","a","transcription","factor","to","the","transcriptional","machinery",".","The","mediator","complex","is","required","for","activation","of","transcription","of","most","protein-coding","genes",",","but","can","also","act","as","a","transcriptional","corepressor",".","The","Saccharomyces","complex","contains","several","identifiable","subcomplexes",":","a","head","domain","comprising","Srb2",",","-4",",","and","-5",",","Med6",",","-8",",","and","-11",",","and","Rox3","proteins",";","a","middle","domain","comprising","Med1",",","-4",",","and","-7",",","Nut1","and","-2",",","Cse2",",","Rgr1",",","Soh1",",","and","Srb7","proteins",";","a","tail","consisting","of","Gal11p",",","Med2p",",","Pgd1p",",","and","Sin4p",";","and","a","regulatory","subcomplex","comprising","Ssn2",",","-3",",","and","-8",",","and","Srb8","proteins",".","Metazoan","mediator","complexes","have","similar","modular","structures","and","include","homologs","of","yeast","Srb","and","Med","proteins","."),4305502). assertion_content_comment('tOboGo_MediolateralIntercalation',s("The","interdigitation","of","cells","along","the","mediolateral","axis","during","gastrulation","."),4109090). assertion_content_comment('tOboGo_MedullaOblongataDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","medulla","oblongata","over","time",",","from","its","formation","to","the","mature","structure",".","The","medulla","oblongata","lies","directly","above","the","spinal","cord","and","controls","vital","autonomic","functions","such","as","digestion",",","breathing","and","the","control","of","heart","rate","."),4042517). assertion_content_comment('tOboGo_MedullaOblongataFormation',s("The","process","that","gives","rise","to","the","medulla","oblongata",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","medulla","oblongata","lies","directly","above","the","spinal","cord","and","controls","vital","autonomic","functions","such","as","digestion",",","breathing","and","the","control","of","heart","rate","."),4043408). assertion_content_comment('tOboGo_MedullaOblongataMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","medulla","oblongata","to","attain","its","fully","functional","state",".","The","medulla","oblongata","lies","directly","above","the","spinal","cord","and","controls","vital","autonomic","functions","such","as","digestion",",","breathing","and","the","control","of","heart","rate","."),4043249). assertion_content_comment('tOboGo_MedullaOblongataMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","medulla","oblongata","is","generated","and","organized",".","The","medulla","oblongata","lies","directly","above","the","spinal","cord","and","controls","vital","autonomic","functions","such","as","digestion",",","breathing","and","the","control","of","heart","rate","."),4043181). assertion_content_comment('tOboGo_MedullaOblongataStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","medulla","oblongata",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","medulla","oblongata","lies","directly","above","the","spinal","cord","and","controls","vital","autonomic","functions","such","as","digestion",",","breathing","and","the","control","of","heart","rate","."),4043231). assertion_content_comment('tOboGo_MedullaReticulospinalTractMorphogenesis',s("Generation","of","a","long","process","of","a","CNS","neuron",",","that","carries","efferent","(","outgoing",")","action","potentials","from","the","cell","body","in","the","medulla","towards","target","cells","in","the","spinal","cord","."),4048109). assertion_content_comment('tOboGo_Megagametogenesis',s("The","process","whose","specific","outcome","is","the","progression","of","the","embryo","sac","over","time",",","from","its","formation","as","the","megaspore","to","the","mature","structure",".","The","process","begins","when","three","of","the","four","haploid","megaspores","disintegrate",",","and","the","fourth","undergoes","mitosis","giving","rise","to","a","binucleate","syncytial","embryo","sac",".","The","two","haploid","nuclei","migrate","to","the","opposite","poles","of","the","embryo","sac","and","then","undergo","two","rounds","of","mitosis","generating","four","haploid","nuclei","at","each","pole",".","One","nucleus","from","each","set","of","four","migrates","to","the","center","of","the","cell",".","Cellularization","occurs",",","resulting","in","an","eight-nucleate","seven-celled","structure",".","This","structure","contains","two","synergid","cells","and","an","egg","cell","at","the","micropylar","end",",","and","three","antipodal","cells","at","the","other","end",".","A","binucleate","endosperm","mother","cell","is","formed","at","the","center","."),4022827). assertion_content_comment('tOboGo_MegagametophyteEggCellNucleus',s("The","nucleus","of","a","plant","egg","cell",".","This","nucleus","is","found","at","the","micropylar","end","of","the","embryo","."),4317863). assertion_content_comment('tOboGo_MegakaryocyteDifferentiation',s("The","process","in","which","a","myeloid","precursor","cell","acquires","specializes","features","of","a","megakaryocyte","."),4087741). assertion_content_comment('tOboGo_Megasome',s("Large",",","cysteine","proteinase","rich","lysosomes",",","often","found","in","the","amastigote","(","an","intracytoplasmic",",","nonflagellated","form","of","the","parasite",")","stage","of","Leishmania","species","belonging","to","the","mexicana","complex","."),4318605). assertion_content_comment('tOboGo_MegasporocyteNucleus',s("The","nucleus","of","a","megasporocyte",",","a","diploid","cell","that","undergoes","meiosis","to","produce","four","megaspores",",","and","its","descendents","."),4317801). assertion_content_comment('tOboGo_Megasporogenesis',s("The","process","in","which","the","megasporocyte","undergoes","meiosis",",","giving","rise","to","four","haploid","megaspores","in","the","nucellus","."),4023138). assertion_content_comment('tOboGo_Mei2NuclearDot',s("A","nuclear","body","that","forms","during","meiotic","prophase","in","a","fixed","position","in","the","horsetail","nucleus",";","contains","Mei2","and","meiRNA",".","May","play","a","role","in","the","progression","of","meiosis","I","."),4341603). assertion_content_comment('tOboGo_MeiosisIINuclearEnvelopeDisassembly',s("The","controlled","breakdown","of","the","nuclear","envelope","during","the","second","division","of","meiosis","."),4119543). assertion_content_comment('tOboGo_MeiosisIINuclearEnvelopeReassembly',s("The","reformation","of","the","nuclear","envelope","during","meiosis","II","."),4118004). assertion_content_comment('tOboGo_MeiosisII',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","second","phase","of","meiosis",",","in","which","cells","divide","and","separate","the","two","chromatids","in","each","chromosome","."),4011841). assertion_content_comment('tOboGo_MeiosisINuclearEnvelopeDisassembly',s("The","controlled","breakdown","of","the","nuclear","envelope","during","the","first","division","of","meiosis","."),4119530). assertion_content_comment('tOboGo_MeiosisINuclearEnvelopeReassembly',s("The","reformation","of","the","nuclear","envelope","during","meiosis","I","."),4117994). assertion_content_comment('tOboGo_MeiosisI',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","first","phase","of","meiosis",",","in","which","cells","divide","and","homologous","chromosomes","are","paired","and","segregated","from","each","other",",","producing","two","daughter","cells","."),3973660). assertion_content_comment('tOboGo_Meiosis',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","nuclear","division","phase","of","a","meiotic","cell","cycle",",","the","specialized","nuclear","and","cell","division","in","which","a","single","diploid","cell","undergoes","two","nuclear","divisions","following","a","single","round","of","DNA","replication","in","order","to","produce","four","daughter","cells","that","contain","half","the","number","of","chromosomes","as","the","diploid","cell",".","Meiotic","division","occurs","during","the","formation","of","gametes","from","diploid","organisms","and","at","the","beginning","of","haplophase","in","those","organisms","that","alternate","between","diploid","and","haploid","generations","."),3973658). assertion_content_comment('tOboGo_MeioticAnaphaseII',s("Anaphase","occurring","as","part","of","meiosis","II",".","Anaphase","is","the","part","of","nuclear","division","in","which","sister","chromatids","(","or","chromosomes",")","separate","and","migrate","towards","the","poles","of","the","spindle",".","Meiosis","II","is","the","second","phase","of","meiosis",",","in","which","cells","divide","and","separate","the","two","chromatids","in","each","chromosome","."),4011871). assertion_content_comment('tOboGo_MeioticAnaphaseI',s("Anaphase","occurring","as","part","of","meiosis","I",".","Anaphase","is","the","part","of","nuclear","division","in","which","chromosomes","separate","and","migrate","towards","the","poles","of","the","spindle",".","Meiosis","I","is","the","first","phase","of","meiosis",",","in","which","cells","divide","and","homologous","chromosomes","are","paired","and","segregated","from","each","other","."),4011997). assertion_content_comment('tOboGo_MeioticCellCycleCheckpoint',s("A","cell","cycle","checkpoint","that","ensures","accurate","chromosome","replication","and","segregation","by","preventing","progression","through","a","meiotic","cell","cycle","until","conditions","are","suitable","for","the","cell","to","proceed","to","the","next","stage","."),4121330). assertion_content_comment('tOboGo_MeioticCellCycleDNAReplicationCheckpoint',s("A","cell","cycle","checkpoint","that","acts","during","a","meiotic","cell","cycle","and","prevents","the","initiation","of","mitosis","until","DNA","replication","is","complete",",","thereby","ensuring","that","progeny","inherit","a","full","complement","of","the","haploid","genome","."),4127993). assertion_content_comment('tOboGo_MeioticCellCycle',s("Progression","through","the","phases","of","the","meiotic","cell","cycle",",","in","which","canonically","a","cell","replicates","to","produce","four","offspring","with","half","the","chromosomal","content","of","the","progenitor","cell","."),3972996). assertion_content_comment('tOboGo_MeioticChromosomeCondensation',s("Compaction","of","chromatin","structure","prior","to","meiosis","in","eukaryotic","cells","."),4330093). assertion_content_comment('tOboGo_MeioticChromosomeDecondensation',s("The","cell","cycle","process","in","which","chromosome","structure","is","altered","from","the","condensed","form","held","during","meiosis","to","the","relaxed","dispersed","form","held","in","resting","cells","."),4119735). assertion_content_comment('tOboGo_MeioticChromosomeMovementTowardsSpindlePole',s("The","cell","cycle","process","in","which","the","directed","movement","of","chromosomes","from","the","center","of","the","spindle","towards","the","spindle","poles","takes","place",",","mediated","by","the","shortening","of","microtubules","attached","to","the","chromosomes",".","This","occurs","during","meiosis","."),4034453). assertion_content_comment('tOboGo_MeioticChromosomeSegregation',s("The","process","in","which","genetic","material",",","in","the","form","of","chromosomes",",","is","organized","into","specific","structures","and","then","physically","separated","and","apportioned","to","two","or","more","sets","during","M","phase","of","the","meiotic","cell","cycle","."),3977131). assertion_content_comment('tOboGo_MeioticChromosomeSeparation',s("The","process","in","which","chromosomes","are","physically","detached","from","each","other","during","meiosis","."),3977133). assertion_content_comment('tOboGo_MeioticChromosome',s("OBSOLETE",".","A","chromosome","involved","in","the","process","of","meiosis","."),4219740). assertion_content_comment('tOboGo_MeioticCohesinComplex',s("A","cohesin","complex","that","mediates","sister","chromatid","cohesion","during","meiosis",";","has","a","subunit","composition","distinct","from","that","of","the","mitotic","cohesin","complex","."),4307072). assertion_content_comment('tOboGo_MeioticDNARecombinaseAssemblyInvolvedInMeioticGeneConversion',s("The","aggregation",",","arrangement","and","bonding","together","of","strand","exchange","proteins","(","recombinases",")","to","form","higher","order","oligomers","on","single-stranded","DNA","resulting","in","meiotic","gene","conversion",".","Meiotic","gene","conversion","is","the","cell","cycle","process","in","which","genetic","information","is","transferred","from","one","helix","to","another","."),4025114). assertion_content_comment('tOboGo_MeioticDNARecombinaseAssemblyInvolvedInReciprocalMeioticRecombination',s("The","aggregation",",","arrangement","and","bonding","together","of","strand","exchange","proteins","(","recombinases",")","to","form","higher","order","oligomers","on","single-stranded","DNA","resulting","in","meiotic","recombination",".","Meiotic","recombination","is","the","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","."),4025104). assertion_content_comment('tOboGo_MeioticDNARecombinaseAssembly',s("During","meiosis",",","the","aggregation",",","arrangement","and","bonding","together","of","strand","exchange","proteins","(","recombinases",")","to","form","higher","order","oligomers","on","single-stranded","DNA","."),3977273). assertion_content_comment('tOboGo_MeioticDNARepairSynthesisInvolvedInMeioticGeneConversion',s("The","synthesis","of","DNA","proceeding","from","the","broken","3","'","single-strand","DNA","end","that","uses","the","homologous","intact","duplex","as","the","template","resulting","in","meiotic","gene","conversion",".","Meiotic","gene","conversion","is","the","cell","cycle","process","in","which","genetic","information","is","transferred","from","one","helix","to","another","."),4025195). assertion_content_comment('tOboGo_MeioticDNARepairSynthesisInvolvedInReciprocalMeioticRecombination',s("The","synthesis","of","DNA","proceeding","from","the","broken","3","'","single-strand","DNA","end","that","uses","the","homologous","intact","duplex","as","the","template","resulting","in","meiotic","recombination",".","Meiotic","recombination","is","the","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","."),4025164). assertion_content_comment('tOboGo_MeioticDNARepairSynthesis',s("During","meiosis",",","the","synthesis","of","DNA","proceeding","from","the","broken","3","'","single-strand","DNA","end","that","uses","the","homologous","intact","duplex","as","the","template","."),3977095). assertion_content_comment('tOboGo_MeioticG2MITransition',s("The","cell","cycle","process","in","which","a","cell","progresses","from","meiotic","prophase","to","metaphase","I","."),4020788). assertion_content_comment('tOboGo_MeioticGeneConversion',s("The","cell","cycle","process","in","which","genetic","information","is","transferred","from","one","helix","to","another",".","It","often","occurs","in","association","with","general","genetic","recombination","events",",","and","is","believed","to","be","a","straightforward","consequence","of","the","mechanisms","of","general","recombination","and","DNA","repair",".","For","example",",","meiosis","might","yield","three","copies","of","the","maternal","version","of","an","allele","and","only","one","copy","of","the","paternal","allele",",","indicating","that","one","of","the","two","copies","of","the","paternal","allele","has","been","changed","to","a","copy","of","the","maternal","allele","."),4011206). assertion_content_comment('tOboGo_MeioticHeteroduplexFormation',s("During","meiosis",",","the","formation","of","a","stable","duplex","DNA","that","contains","one","strand","from","each","of","the","two","recombining","DNA","molecules","."),3976875). assertion_content_comment('tOboGo_MeioticJointMoleculeFormation',s("The","conversion","of","the","paired","broken","DNA","and","homologous","duplex","DNA","into","a","four-stranded","branched","intermediate",",","known","as","a","joint","molecule",",","formed","during","meiotic","recombination",".","These","joint","molecules","contain","Holliday","junctions","on","either","side","of","heteroduplex","DNA","."),3977029). assertion_content_comment('tOboGo_MeioticMetaphaseIIPlateCongression',s("The","alignment","of","chromosomes","at","the","metaphase","plate",",","a","plane","halfway","between","the","poles","of","the","meiotic","spindle",",","during","meiosis","II","."),4094271). assertion_content_comment('tOboGo_MeioticMetaphaseII',s("Metaphase","occurring","as","part","of","meiosis","II",".","Metaphase","is","the","part","of","nuclear","division","in","which",",","canonically",",","chromosomes","become","aligned","on","the","equatorial","plate","of","the","cell",".","Meiosis","II","is","the","second","phase","of","meiosis",",","in","which","cells","divide","and","separate","the","two","chromatids","in","each","chromosome","."),4011861). assertion_content_comment('tOboGo_MeioticMetaphaseIPlateCongression',s("The","alignment","of","chromosomes","at","the","metaphase","plate",",","a","plane","halfway","between","the","poles","of","the","meiotic","spindle",",","during","meiosis","I","."),4060031). assertion_content_comment('tOboGo_MeioticMetaphaseI',s("Metaphase","occurring","as","part","of","meiosis","I",".","Metaphase","is","the","part","of","nuclear","division","in","which",",","canonically",",","chromosomes","become","aligned","on","the","equatorial","plate","of","the","cell",".","Meiosis","I","is","the","first","phase","of","meiosis",",","in","which","cells","divide","and","homologous","chromosomes","are","paired","and","segregated","from","each","other","."),4011930). assertion_content_comment('tOboGo_MeioticMetaphasePlateCongression',s("The","cell","cycle","process","in","which","chromosomes","are","aligned","at","the","metaphase","plate",",","a","plane","halfway","between","the","poles","of","the","meiotic","spindle",",","during","meiosis","."),4060014). assertion_content_comment('tOboGo_MeioticMismatchRepairInvolvedInMeioticGeneConversion',s("A","system","for","the","identification","and","correction","of","base-base","mismatches",",","small","insertion-deletion","loops",",","and","regions","of","heterology","that","are","present","in","duplex","DNA","formed","with","strands","from","two","recombining","molecules","resulting","in","meiotic","gene","conversion",".","Meiotic","gene","conversion","is","the","cell","cycle","process","in","which","genetic","information","is","transferred","from","one","helix","to","another","."),4025144). assertion_content_comment('tOboGo_MeioticMismatchRepairInvolvedInReciprocalMeioticRecombination',s("A","system","for","the","identification","and","correction","of","base-base","mismatches",",","small","insertion-deletion","loops",",","and","regions","of","heterology","that","are","present","in","duplex","DNA","formed","with","strands","from","two","recombining","molecules","resulting","in","meiotic","recombination",".","Meiotic","recombination","is","the","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","."),4025154). assertion_content_comment('tOboGo_MeioticMismatchRepair',s("A","system","for","the","identification","and","correction","of","base-base","mismatches",",","small","insertion-deletion","loops",",","and","regions","of","heterology","that","are","present","in","duplex","DNA","formed","with","strands","from","two","recombining","molecules",".","Correction","of","the","mismatch","can","result","in","non-Mendelian","segregation","of","alleles","following","meiosis","."),3977055). assertion_content_comment('tOboGo_MeioticNuclearEnvelopeDisassembly',s("The","cell","cycle","process","in","which","the","controlled","breakdown","of","the","nuclear","envelope","during","meiotic","cell","division","occurs","."),4119524). assertion_content_comment('tOboGo_MeioticNuclearEnvelopeReassembly',s("The","cell","cycle","process","in","which","the","reformation","of","the","nuclear","envelope","during","meiosis","occurs","."),4117974). assertion_content_comment('tOboGo_MeioticProphaseII',s("Prophase","occurring","as","part","of","meiosis","II",".","Prophase","is","the","part","of","nuclear","division","in","which",",","canonically",",","chromosomes","condense","and","the","two","daughter","centrioles","and","their","asters","migrate","toward","the","poles","of","the","cell",".","Meiosis","II","is","the","second","phase","of","meiosis",",","in","which","cells","divide","and","separate","the","two","chromatids","in","each","chromosome","."),4011987). assertion_content_comment('tOboGo_MeioticProphaseI',s("Prophase","occurring","as","part","of","meiosis","I",".","Prophase","is","the","part","of","nuclear","division","in","which",",","canonically",",","chromosomes","condense","and","the","two","daughter","centrioles","and","their","asters","migrate","toward","the","poles","of","the","cell",".","Meiosis","I","is","the","first","phase","of","meiosis",",","in","which","cells","divide","and","homologous","chromosomes","are","paired","and","segregated","from","each","other","."),3973662). assertion_content_comment('tOboGo_MeioticRecombinationCheckpoint',s("A","checkpoint","that","acts","during","late","prophase","I","(","pachytene",")","and","prevents","segregation","of","homologous","chromosomes","until","recombination","is","completed",",","ensuring","proper","distribution","of","the","genetic","material","to","the","gametes","."),4121334). assertion_content_comment('tOboGo_MeioticRecombinationInitiationComplex',s("A","protein","complex","that","initiates","the","formation","of","double-strand","breaks","(","DSBs",")","required","for","meiotic","recombination",".","Consists","of","a","protein","that","catalyses","formation","of","the","double-strand","breaks","(","Spo11","in","S",".","cerevisiae","and","Rec12","in","S",".","pombe",")",",","and","a","number","of","accessory","proteins","."),4081035). assertion_content_comment('tOboGo_MeioticRecombinationNoduleAssembly',s("During","meiosis",",","the","aggregation",",","arrangement","and","bonding","together","of","strand","exchange","proteins","(","recombinases",")","to","form","small",",","electron","dense","structures","in","association","with","meiotic","chromosomes","."),4236158). assertion_content_comment('tOboGo_MeioticSeptinComplex',s("A","heterooligomeric","septin","complex","that","acts","during","meiotic","cell","division","."),4329184). assertion_content_comment('tOboGo_MeioticSisterChromatidArmSeparation',s("The","cell","cycle","process","in","which","sister","chromatid","arms","are","physically","detached","from","each","other","during","meiosis","."),4122166). assertion_content_comment('tOboGo_MeioticSisterChromatidCentromereSeparation',s("The","cell","cycle","process","in","which","the","centromeres","of","sister","chromatids","are","physically","detached","from","each","other","during","meiosis","."),4122155). assertion_content_comment('tOboGo_MeioticSisterChromatidCohesionArms',s("The","cell","cycle","process","in","which","the","sister","chromatids","of","a","replicated","chromosome","are","joined","along","the","length","of","the","chromosome","arms","during","meiosis","."),4122188). assertion_content_comment('tOboGo_MeioticSisterChromatidCohesionCentromeric',s("The","cell","cycle","process","in","which","centromeres","of","sister","chromatids","are","joined","during","meiosis","."),4122176). assertion_content_comment('tOboGo_MeioticSisterChromatidCohesionInvolvedInMeiosisII',s("The","cell","cycle","process","in","which","sister","chromatids","of","a","replicated","chromosome","are","joined","along","the","entire","length","of","the","chromosome","during","meiosis","II","."),4025472). assertion_content_comment('tOboGo_MeioticSisterChromatidCohesionInvolvedInMeiosisI',s("The","cell","cycle","process","in","which","sister","chromatids","of","a","replicated","chromosome","are","joined","along","the","entire","length","of","the","chromosome","during","meiosis","I","."),4025482). assertion_content_comment('tOboGo_MeioticSisterChromatidCohesion',s("The","cell","cycle","process","in","which","sister","chromatids","of","a","replicated","chromosome","are","joined","along","the","entire","length","of","the","chromosome","during","meiosis","."),4013124). assertion_content_comment('tOboGo_MeioticSisterChromatidSegregation',s("The","cell","cycle","process","in","which","sister","chromatids","are","organized","and","then","physically","separated","and","randomly","apportioned","to","two","sets","during","the","second","division","of","the","meiotic","cell","cycle","."),4086661). assertion_content_comment('tOboGo_MeioticSisterChromatidSeparation',s("The","process","in","which","sister","chromatids","are","physically","detached","from","each","other","during","meiosis","."),4122152). assertion_content_comment('tOboGo_MeioticSpindleAssemblyCheckpoint',s("A","cell","cycle","checkpoint","that","delays","the","metaphase/anaphase","transition","of","a","meiotic","cell","cycle","until","the","spindle","is","correctly","assembled","and","chromosomes","are","attached","to","the","spindle","."),4127548). assertion_content_comment('tOboGo_MeioticSpindleDisassembly',s("The","controlled","breakdown","of","the","spindle","during","a","meiotic","cell","cycle","."),4287626). assertion_content_comment('tOboGo_MeioticSpindleElongation',s("The","lengthening","of","the","distance","between","poles","of","the","spindle","during","a","meiotic","cell","cycle","."),4120074). assertion_content_comment('tOboGo_MeioticSpindleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","microtubule","spindle","during","a","meiotic","cell","cycle","."),3973007). assertion_content_comment('tOboGo_MeioticSpindleStabilization',s("The","cell","cycle","process","in","which","spindle","integrity","is","maintained","during","M","phase","of","meiosis","."),4092924). assertion_content_comment('tOboGo_MeioticStrandDisplacement',s("The","cell","cycle","process","in","which","the","broken","3","'","single-strand","DNA","molecule","that","formed","heteroduplex","DNA","with","its","complement","in","an","intact","duplex","DNA","is","rejected",".","The","Watson-Crick","base","pairing","in","the","original","duplex","is","restored",".","The","rejected","3","'","single-strand","DNA","molecule","reanneals","with","its","original","complement","to","reform","two","intact","duplex","molecules",".","This","occurs","during","meiosis","."),3976901). assertion_content_comment('tOboGo_MeioticStrandInvasionInvolvedInMeioticGeneConversion',s("The","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","resulting","in","meiotic","recombination","."),4025134). assertion_content_comment('tOboGo_MeioticStrandInvasionInvolvedInReciprocalMeioticRecombination',s("The","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","resulting","in","meiotic","recombination",".","Meiotic","recombination","is","the","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","."),4025124). assertion_content_comment('tOboGo_MeioticStrandInvasion',s("The","cell","cycle","process","in","which","the","nucleoprotein","complex","(","composed","of","the","broken","single-strand","DNA","and","the","recombinase",")","searches","and","identifies","a","region","of","homology","in","intact","duplex","DNA",".","The","broken","single-strand","DNA","displaces","the","like","strand","and","forms","Watson-Crick","base","pairs","with","its","complement",",","forming","a","duplex","in","which","each","strand","is","from","one","of","the","two","recombining","DNA","molecules",".","This","occurs","during","meiosis","."),3977000). assertion_content_comment('tOboGo_MeioticTelomereClustering',s("The","cell","cycle","process","in","which","the","dynamic","reorganization","of","telomeres","occurs","in","early","meiotic","prophase",",","during","which","meiotic","chromosome","ends","are","gathered","in","a","bouquet","arrangement","at","the","inner","surface","of","the","nuclear","envelope","proximal","to","the","spindle","pole","body",".","This","plays","an","important","role","in","homologous","chromosome","pairing","and","therefore","progression","through","meiosis","."),4054946). assertion_content_comment('tOboGo_MeioticTelophaseII',s("Telophase","occurring","as","part","of","meiosis","II",".","Telophase","is","the","part","of","nuclear","division","that",",","canonically",",","begins","when","the","chromosomes","arrive","at","the","poles","of","the","cell","and","the","division","of","the","cytoplasm","starts",".","Meiosis","II","is","the","second","phase","of","meiosis",",","in","which","cells","divide","and","separate","the","two","chromatids","in","each","chromosome","."),4011851). assertion_content_comment('tOboGo_MeioticTelophaseI',s("Telophase","occurring","as","part","of","meiosis","I",".","Telophase","is","the","part","of","nuclear","division","that",",","canonically",",","begins","when","the","chromosomes","arrive","at","the","poles","of","the","cell","and","the","division","of","the","cytoplasm","starts",".","Meiosis","I","is","the","first","phase","of","meiosis",",","in","which","cells","divide","and","homologous","chromosomes","are","paired","and","segregated","from","each","other","."),4012007). assertion_content_comment('tOboGo_MelaninBiosyntheticProcessFromTyrosine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","melanin","from","other","compounds",",","including","tyrosine","."),4232014). assertion_content_comment('tOboGo_MelaninBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","melanins",",","pigments","largely","of","animal","origin",".","High","molecular","weight","polymers","of","indole","quinone",",","they","are","irregular","polymeric","structures","and","are","divided","into","three","groups",":","allomelanins","in","the","plant","kingdom","and","eumelanins","and","phaeomelanins","in","the","animal","kingdom","."),4104430). assertion_content_comment('tOboGo_MelaninCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","melanins",",","pigments","largely","of","animal","origin",".","High","molecular","weight","polymers","of","indole","quinone",",","they","are","irregular","polymeric","structures","and","are","divided","into","three","groups",":","allomelanins","in","the","plant","kingdom","and","eumelanins","and","phaeomelanins","in","the","animal","kingdom","."),4352022). assertion_content_comment('tOboGo_MelaninMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","melanins",",","pigments","largely","of","animal","origin",".","High","molecular","weight","polymers","of","indole","quinone",",","they","are","irregular","polymeric","structures","and","are","divided","into","three","groups",":","allomelanins","in","the","plant","kingdom","and","eumelanins","and","phaeomelanins","in","the","animal","kingdom","."),4072428). assertion_content_comment('tOboGo_MelanizationDefenseResponse',s("The","blackening","of","the","wounded","area","of","the","cuticle","or","the","surface","of","invading","pathogens",",","parasites","or","parasitoids",",","resulting","from","a","proteolytic","cascade","leading","to","the","de","novo","synthesis","and","deposition","of","melanin","."),4072432). assertion_content_comment('tOboGo_MelanocortinReceptorActivity',s("Combining","with","melanocortin","to","initiate","a","change","in","cell","activity","."),4198063). assertion_content_comment('tOboGo_MelanocortinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","melanocortin","receptor","."),4177757). assertion_content_comment('tOboGo_MelanocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","melanocyte","."),4086886). assertion_content_comment('tOboGo_MelanosomeLocalization',s("Any","process","in","which","a","melanosome","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell","."),4056441). assertion_content_comment('tOboGo_MelanosomeLumen',s("The","volume","enclosed","by","the","melanosome","membrane","."),4074779). assertion_content_comment('tOboGo_MelanosomeMembrane',s("The","lipid","bilayer","surrounding","a","melanosome","."),4065376). assertion_content_comment('tOboGo_MelanosomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","melanosome",".","A","melanosome","is","a","tissue-specific",",","membrane-bounded","cytoplasmic","organelle","within","which","melanin","pigments","are","synthesized","and","stored","."),4334804). assertion_content_comment('tOboGo_Melanosome',s("A","tissue-specific",",","membrane-bounded","cytoplasmic","organelle","within","which","melanin","pigments","are","synthesized","and","stored",".","Melanosomes","are","synthesized","in","melanocyte","cells","."),4065365). assertion_content_comment('tOboGo_MelanosomeTransport',s("The","directed","movement","of","melanosomes","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4334966). assertion_content_comment('tOboGo_MelanoticEncapsulationOfForeignTarget',s("Formation","of","a","multilayered",",","melanized","sheath","of","cells","around","a","foreign","invader","."),4381898). assertion_content_comment('tOboGo_MelanoticTumorResponse',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4232507). assertion_content_comment('tOboGo_MelatoninBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","melatonin","(","N-acetyl-5-methoxytryptamine",")"),4311448). assertion_content_comment('tOboGo_MelatoninCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","melatonin","(","N-acetyl-5-methoxytryptamine",")"),4313402). assertion_content_comment('tOboGo_MelatoninMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","melatonin","(","N-acetyl-5-methoxytryptamine",")"),4311413). assertion_content_comment('tOboGo_MelatoninReceptorActivity',s("Combining","with","melatonin",",","N-acetyl-5-methoxytryptamine",",","to","initiate","a","change","in","cell","activity",".","Melatonin","is","a","neuroendocrine","substance","that","stimulates","the","aggregation","of","melanosomes","in","melanophores",",","thus","lightening","the","skin","."),4254777). assertion_content_comment('tOboGo_MelatoninReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","melatonin","receptor","."),4322932). assertion_content_comment('tOboGo_MelibioseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","melibiose",",","the","disaccharide","6-O-alpha-D-galactopyranosyl-D-glucose","."),4313179). assertion_content_comment('tOboGo_MelibioseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","melibiose",",","the","disaccharide","6-O-alpha-D-galactopyranosyl-D-glucose","."),4220837). assertion_content_comment('tOboGo_MelibioseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","melibiose",",","the","disaccharide","6-O-alpha-D-galactopyranosyl-D-glucose","."),4220804). assertion_content_comment('tOboGo_Melibiose_MonovalentCationSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","melibiose","(","out",")","+","monovalent","cation","(","out",")","=","melibiose","(","in",")","+","monovalent","cation","(","in",")"),4292467). assertion_content_comment('tOboGo_Melibiose_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","melibiose","(","out",")","+","Na","+","(","out",")","=","melibiose","(","in",")","+","Na","+","(","in",")"),4328854). assertion_content_comment('tOboGo_MelibioseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","melibiose","from","one","side","of","the","membrane","to","the","other",".","Melibiose","is","the","disaccharide","6-O-alpha-D-galactopyranosyl-D-glucose","and","occurs","as","a","constituent","of","the","trisaccharide","raffinose","or","in","the","exudates","and","nectaries","of","a","number","of","plants","."),4292464). assertion_content_comment('tOboGo_MelibioseTransport',s("The","directed","movement","of","melibiose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Melibiose","is","the","disaccharide","6-O-alpha-D-galactopyranosyl-D-glucose","."),4291192). assertion_content_comment('tOboGo_MembraneAdditionAtSiteOfCytokinesis',s("Any","process","involved","in","the","net","addition","of","membrane","at","the","site","of","cytokinesis",";","includes","vesicle","recruitment","and","fusion",",","local","lipid","synthesis","and","insertion","."),4236008). assertion_content_comment('tOboGo_MembraneAlanylAminopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","an","N-terminal","amino","acid",",","Xaa-Xbb-","from","a","peptide",",","amide","or","arylamide",".","Xaa","is","preferably","Ala",",","but","may","be","most","amino","acids","including","Pro","(","slow","action",")","When","a","terminal","hydrophobic","residue","is","followed","by","a","prolyl","residue",",","the","two","may","be","released","as","an","intact","Xaa-Pro","dipeptide","."),4210822). assertion_content_comment('tOboGo_MembraneAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","membrane","."),4054917). assertion_content_comment('tOboGo_MembraneAssociatedActinBinding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4192970). assertion_content_comment('tOboGo_MembraneAttackComplexProteinAlphaMChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218505). assertion_content_comment('tOboGo_MembraneAttackComplexProteinBeta2Chain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4247430). assertion_content_comment('tOboGo_MembraneAttackComplex',s("A","protein","complex","produced","by","sequentially","activated","components","of","the","complement","cascade","inserted","into","a","target","cell","membrane","and","forming","a","pore","leading","to","cell","lysis","via","ion","and","water","flow","."),4007099). assertion_content_comment('tOboGo_MembraneBiogenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","membrane","."),4040701). assertion_content_comment('tOboGo_MembraneBudding',s("The","evagination","of","a","membrane",",","resulting","in","formation","of","a","vesicle","."),4004836). assertion_content_comment('tOboGo_MembraneCoat',s("Any","of","several","different","proteinaceous","coats","that","can","associate","with","membranes",".","Membrane","coats","include","those","formed","by","clathrin","plus","an","adaptor","complex",",","the","COPI","and","COPII","complexes",",","and","possibly","others",".","They","are","found","associated","with","membranes","on","many","vesicles","as","well","as","other","membrane","features","such","as","pits","and","perhaps","tubules","."),4053028). assertion_content_comment('tOboGo_MembraneDepolarization',s("The","process","in","which","membrane","potential","changes","in","the","depolarizing","direction","from","the","resting","potential",",","usually","from","negative","to","positive",".","For","example",",","the","initial","depolarization","during","the","rising","phase","of","an","action","potential","is","in","the","direction","from","the","negative","resting","potential","towards","the","positive","membrane","potential","that","will","be","the","peak","of","the","action","potential","."),4003099). assertion_content_comment('tOboGo_MembraneDipeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","dipeptides","."),4209967). assertion_content_comment('tOboGo_MembraneDisassembly',s("The","controlled","breakdown","of","any","cell","membrane","in","the","context","of","a","normal","process","such","as","autophagy","."),4012682). assertion_content_comment('tOboGo_MembraneDisruptionInOtherOrganism',s("The","disruption","of","the","membranes","of","another","organism",",","leading","to","damage","to","its","cells","and","possibly","death","of","that","organism","."),4285470). assertion_content_comment('tOboGo_MembraneDocking',s("The","initial","attachment","of","a","membrane","or","protein","to","a","target","membrane",".","Docking","requires","only","that","the","proteins","come","close","enough","to","interact","and","adhere","."),3988758). assertion_content_comment('tOboGo_MembraneFissionInvolvedInMitochondrialFission',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","separation","of","a","single","continuous","mitochondrial","membrane","into","two","membranes","and","contributes","to","mitochondrial","fission","."),4149188). assertion_content_comment('tOboGo_MembraneFission',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","separation","of","a","single","continuous","membrane","into","two","membranes","."),4005541). assertion_content_comment('tOboGo_MembraneFraction',s("That","fraction","of","cells",",","prepared","by","disruptive","biochemical","methods",",","that","includes","the","plasma","and","other","membranes","."),3988370). assertion_content_comment('tOboGo_MembraneFusionInvolvedInAcrosomeReaction',s("The","fusion","of","the","plasma","membrane","of","the","sperm","with","the","outer","acrosomal","membrane","."),3990193). assertion_content_comment('tOboGo_MembraneFusion',s("The","membrane","organization","process","that","joins","two","lipid","bilayers","to","form","a","single","membrane","."),3969889). assertion_content_comment('tOboGo_MembraneHyperpolarization',s("The","process","in","which","membrane","potential","changes","in","the","hyperpolarizing","direction","from","the","resting","potential",",","usually","from","negative","to","more","negative","."),4159443). assertion_content_comment('tOboGo_MembraneInsertaseActivity',s("Mediates","the","integration","of","proteins","into","a","membrane","from","the","inner","side","of","the","membrane",".","Membrane","insertases","are","highly","conserved","and","include","the","bacterial","YidC","family",",","the","plant","chloroplast","Alb3","family",",","and","the","fungal","and","animal","mitochondrial","Oxa1/Cox18","family","."),4337128). assertion_content_comment('tOboGo_MembraneInvagination',s("The","infolding","of","a","membrane",",","resulting","in","formation","of","a","vesicle","."),3986697). assertion_content_comment('tOboGo_MembraneLipidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","membrane","lipids",",","any","lipid","found","in","or","associated","with","a","biological","membrane","."),4024040). assertion_content_comment('tOboGo_MembraneLipidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","membrane","lipids",",","any","lipid","found","in","or","associated","with","a","biological","membrane","."),4230849). assertion_content_comment('tOboGo_MembraneLipidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","membrane","lipids",",","any","lipid","found","in","or","associated","with","a","biological","membrane","."),4024023). assertion_content_comment('tOboGo_MembraneMacromoleculeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","macromolecule","destined","to","form","part","of","a","membrane","in","a","cell","."),4129295). assertion_content_comment('tOboGo_MembraneOrganization',s("A","process","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","membrane",".","A","membrane","is","a","double","layer","of","lipid","molecules","that","encloses","all","cells",",","and",",","in","eukaryotes",",","many","organelles",";","may","be","a","single","or","double","lipid","bilayer",";","also","includes","associated","proteins","."),3969875). assertion_content_comment('tOboGo_MembranePart',s("Any","constituent","part","of","a","membrane",",","a","double","layer","of","lipid","molecules","that","encloses","all","cells",",","and",",","in","eukaryotes",",","many","organelles",";","may","be","a","single","or","double","lipid","bilayer",";","also","includes","associated","proteins","."),3973155). assertion_content_comment('tOboGo_MembranePotentialDrivenUniporterActivity',s("Enables","the","active","transport","of","a","solute","across","a","membrane","by","a","mechanism","involving","conformational","change",",","where","energy","for","active","transport","is","derived","from","membrane","potential","if","the","solute","is","charged","."),4331111). assertion_content_comment('tOboGo_MembraneProteinEctodomainProteolysis',s("The","proteolytic","cleavage","of","transmembrane","proteins","and","release","of","their","ectodomain","(","extracellular","domain",")"),4119224). assertion_content_comment('tOboGo_MembraneProteinIntracellularDomainProteolysis',s("The","proteolytic","cleavage","of","a","transmembrane","protein","leading","to","the","release","of","an","intracellular","domain","."),4083567). assertion_content_comment('tOboGo_MembraneProteinProteolysis',s("The","proteolytic","cleavage","of","a","transmembrane","protein","leading","to","the","release","of","its","intracellular","or","ecto-domains","."),4083565). assertion_content_comment('tOboGo_MembraneRaftAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","membrane","raft",",","a","small","(","10-200","nm",")",",","heterogeneous",",","highly","dynamic",",","sterol-","and","sphingolipid-enriched","membrane","domains","that","compartmentalizes","cellular","processes","."),4178884). assertion_content_comment('tOboGo_MembraneRaftDistribution',s("The","process","that","establishes","the","spatial","arrangement","of","membrane","rafts","within","a","cellular","membrane","."),4322053). assertion_content_comment('tOboGo_MembraneRaftLocalization',s("Any","process","in","which","membrane","rafts","are","transported","to",",","or","maintained","in",",","a","specific","location",".","Membrane","rafts","are","small","(","10-200","nm",")",",","heterogeneous",",","highly","dynamic",",","sterol-","and","sphingolipid-enriched","membrane","domains","that","compartmentalize","cellular","processes","."),4285426). assertion_content_comment('tOboGo_MembraneRaftOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","membrane","rafts",",","small","(","10-200","nm",")",",","heterogeneous",",","highly","dynamic",",","sterol-","and","sphingolipid-enriched","membrane","domains","that","compartmentalize","cellular","processes","."),4178879). assertion_content_comment('tOboGo_MembraneRaftPolarization',s("The","clustering","and","aggregation","of","membrane","rafts","at","a","single","cellular","pole","during","activation","of","particular","cell","types",",","such","as","lymphocytes","."),4383440). assertion_content_comment('tOboGo_MembraneRaft',s("Any","of","the","small","(","10-200","nm",")",",","heterogeneous",",","highly","dynamic",",","sterol-","and","sphingolipid-enriched","membrane","domains","that","compartmentalize","cellular","processes",".","Small","rafts","can","sometimes","be","stabilized","to","form","larger","platforms","through","protein-protein","and","protein-lipid","interactions","."),3992831). assertion_content_comment('tOboGo_MembraneReorganizationInvolvedInPhagocytosisEngulfment',s("The","assembly","and","arrangement","of","the","plasma","membrane","that","is","involved","in","the","internalization","of","bacteria",",","immune","complexes","and","other","particulate","matter","or","of","an","apoptotic","cell","by","phagocytosis","."),4108731). assertion_content_comment('tOboGo_Membrane',s("Double","layer","of","lipid","molecules","that","encloses","all","cells",",","and",",","in","eukaryotes",",","many","organelles",";","may","be","a","single","or","double","lipid","bilayer",";","also","includes","associated","proteins","."),3972008). assertion_content_comment('tOboGo_MembraneToMembraneDocking',s("The","initial","attachment","of","a","membrane","to","a","target","membrane",",","mediated","by","proteins","protruding","from","the","two","membranes",".","Docking","requires","only","that","the","membranes","come","close","enough","for","the","proteins","to","interact","and","adhere","."),4129849). assertion_content_comment('tOboGo_MembranousSeptumMorphogenesis',s("The","process","in","which","the","membranous","septum","is","generated","and","organized",".","The","membranous","septum","is","the","upper","part","of","ventricular","septum","."),4003662). assertion_content_comment('tOboGo_MemoryBCellDifferentiation',s("The","process","in","which","a","B","cell","acquires","the","specialized","features","of","a","memory","B","cell",".","Memory","B","cells","are","cells","that","can","respond","rapidly","to","antigen","re-exposure","by","production","of","high-affinity","antibody","."),4379885). assertion_content_comment('tOboGo_Memory',s("The","activities","involved","in","the","mental","information","processing","system","that","receives","(","registers",")",",","modifies",",","stores",",","and","retrieves","informational","stimuli",".","The","main","stages","involved","in","the","formation","and","retrieval","of","memory","are","encoding","(","processing","of","received","information","by","acquisition",")",",","storage","(","building","a","permanent","record","of","received","information","as","a","result","of","consolidation",")","and","retrieval","(","calling","back","the","stored","information","and","use","it","in","a","suitable","way","to","execute","a","given","task",")"),4159120). assertion_content_comment('tOboGo_MemoryTCellActivation',s("The","change","in","morphology","and","behavior","of","a","memory","T","cell","resulting","from","exposure","to","a","mitogen",",","cytokine",",","chemokine",",","cellular","ligand",",","or","an","antigen","for","which","it","is","specific","."),4144242). assertion_content_comment('tOboGo_MemoryTCellDifferentiation',s("The","process","in","which","a","newly","activated","T","cell","acquires","specialized","features","of","a","memory","T","cell","."),4095702). assertion_content_comment('tOboGo_MemoryTCellExtravasation',s("The","migration","of","a","memory","T","cell","from","the","blood","vessels","into","the","surrounding","tissue",".","A","memory","T","cell","is","a","distinctly","differentiated","long-lived","T","cell","that","has","the","phenotype","CD45RO-positive","and","CD127-positive","."),4380294). assertion_content_comment('tOboGo_MenaquinoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","of","the","menaquinones",",","any","of","the","quinone-derived","compounds","synthesized","by","intestinal","bacteria",".","Structurally",",","menaquinones","consist","of","a","methylated","naphthoquinone","ring","structure","and","side","chains","composed","of","a","variable","number","of","unsaturated","isoprenoid","residues",".","Menaquinones","have","vitamin","K","activity","and","are","known","as","vitamin","K2","."),4257571). assertion_content_comment('tOboGo_MenaquinoneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","menaquinones",",","any","of","the","quinone-derived","compounds","synthesized","by","intestinal","bacteria",".","Structurally",",","menaquinones","consist","of","a","methylated","naphthoquinone","ring","structure","and","side","chains","composed","of","a","variable","number","of","unsaturated","isoprenoid","residues",".","Menaquinones","have","vitamin","K","activity","and","are","known","as","vitamin","K2","."),4312729). assertion_content_comment('tOboGo_MenaquinoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","of","the","menaquinones",",","quinone-derived","compounds","synthesized","by","intestinal","bacteria",".","Structurally",",","menaquinones","consist","of","a","methylated","naphthoquinone","ring","structure","and","side","chains","composed","of","a","variable","number","of","unsaturated","isoprenoid","residues",".","Menaquinones","have","vitamin","K","activity","and","are","known","as","vitamin","K2","."),4257535). assertion_content_comment('tOboGo_Menarche',s("The","beginning","of","the","menstrual","cycle",";","the","first","menstrual","cycle","in","an","individual","."),4317264). assertion_content_comment('tOboGo_Menopause',s("Cessation","of","menstruation",",","occurring","in","(","e.g.",")","the","human","female","usually","around","the","age","of","50","."),4078415). assertion_content_comment('tOboGo_MenstrualCyclePhase',s("The","progression","of","physiological","phases",",","occurring","in","the","endometrium","during","the","menstrual","cycle","that","recur","at","regular","intervals","during","the","reproductive","years",".","The","menstrual","cycle","is","an","ovulation","cycle","where","the","endometrium","is","shed","if","pregnancy","does","not","occur","."),4078354). assertion_content_comment('tOboGo_Menstruation',s("The","cyclic",",","physiologic","discharge","through","the","vagina","of","blood","and","endometrial","tissues","from","the","nonpregnant","uterus","."),4078356). assertion_content_comment('tOboGo_MentholBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","menthol",",","the","monoterpene","2-isopropyl-5-methylcyclohexanol","."),4321916). assertion_content_comment('tOboGo_MentholMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","menthol",",","the","monoterpene","2-isopropyl-5-methylcyclohexanol","."),4321900). assertion_content_comment('tOboGo_MenthoneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","-",")","-","(","2S",",","5R",")","-menthone","+","NAD","+","=","(","5R",")","-menth-2-enone","+","NADH","+","H","+"),4350683). assertion_content_comment('tOboGo_MeprinAActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","protein","and","peptide","substrates","preferentially","on","carboxyl","side","of","hydrophobic","residues","."),4209989). assertion_content_comment('tOboGo_MeprinAComplex',s("A","protein","complex","that","is","located","in","the","cell","membrane",",","and","is","involved","in","the","metabolism","of","peptides",",","including","neuropeptides",".","The","complex","has","metalloendopeptidase","activity","that","catalyzes","the","hydrolysis","of","protein","and","peptide","substrates",",","preferentially","on","carboxyl","side","of","hydrophobic","residues","."),4040876). assertion_content_comment('tOboGo_MercuricSensitivityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4233785). assertion_content_comment('tOboGo_MercuryIIReductaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","Hg","+","NADP","(","+",")","=","Hg","(","2","+",")","+","NADPH","."),4303236). assertion_content_comment('tOboGo_MercuryIonBinding',s("Interacting","selectively","and","non-covalently","with","mercury","(","Hg",")","ions","."),4298583). assertion_content_comment('tOboGo_MercuryIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","mercury","(","Hg",")","ions","from","one","side","of","a","membrane","to","the","other","."),4297519). assertion_content_comment('tOboGo_MercuryIonTransport',s("The","directed","movement","of","mercury","(","Hg",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4033733). assertion_content_comment('tOboGo_MeristemDeterminacy',s("The","process","in","which","a","meristem","becomes","determinate","(","i.e",".","ceases","to","produce","lateral","organs","and","may","or","may","not","terminally","differentiate",")"),4028384). assertion_content_comment('tOboGo_MeristemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","meristem","over","time",",","from","its","formation","to","the","mature","structure","."),4028380). assertion_content_comment('tOboGo_MeristemGrowth',s("The","increase","in","size","or","mass","of","a","meristem",",","a","region","of","tissue","in","a","plant","that","is","composed","of","one","or","more","undifferentiated","cells","capable","of","undergoing","mitosis","and","differentiation","."),4029429). assertion_content_comment('tOboGo_MeristemInitiation',s("Initiation","of","a","region","of","tissue","in","a","plant","that","is","composed","of","one","or","more","undifferentiated","cells","capable","of","undergoing","mitosis","and","differentiation",",","thereby","effecting","growth","and","development","of","a","plant","by","giving","rise","to","more","meristem","or","specialized","tissue","."),4032489). assertion_content_comment('tOboGo_MeristemMaintenance',s("Any","process","involved","in","maintaining","the","identity",",","size","and","shape","of","a","meristem","."),4028382). assertion_content_comment('tOboGo_MeristemoidMotherCellDivision',s("The","asymmetric","cell","division","by","which","a","meristemoid","mother","cells","(","MMC",")","give","rise","to","a","meristemoid","and","another","cell",".","The","other","cell","may","itself","become","a","MMC","or","may","generate","an","epidermal","cell",".","Any","cell","that","undergoes","this","type","of","division","is","a","MMC","."),4029563). assertion_content_comment('tOboGo_MeristemStructuralOrganization',s("Organization","of","a","region","of","tissue","in","a","plant","that","is","composed","of","one","or","more","undifferentiated","cells","capable","of","undergoing","mitosis","and","differentiation",",","thereby","effecting","growth","and","development","of","a","plant","by","giving","rise","to","more","meristem","or","specialized","tissue","."),4032485). assertion_content_comment('tOboGo_MerozoiteDenseGranuleMembrane',s("The","lipid","bilayer","surrounding","a","dense","granule","of","the","type","found","in","apicomplexan","parasites","."),4051729). assertion_content_comment('tOboGo_MerozoiteDenseGranule',s("Electron-dense","organelle","with","a","granular","internal","matrix","found","throughout","the","merozoite","life","cycle","stage","of","apicomplexan","parasites",";","contains","proteins","destined","to","be","secreted","into","the","parasitophorous","vacuole","following","parasite","invasion","of","a","host","cell","."),4051718). assertion_content_comment('tOboGo_MesangialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","mesangial","cell","in","the","kidney","over","time",",","from","its","formation","to","the","mature","structure","."),4122928). assertion_content_comment('tOboGo_MesangialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","mesangial","cells","of","the","kidney","as","it","progresses","from","its","formation","to","the","mature","state","."),4122918). assertion_content_comment('tOboGo_MesangialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","mesangial","cell","."),4123156). assertion_content_comment('tOboGo_MesectodermDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesectoderm","over","time",",","from","its","formation","to","the","mature","structure",".","In","animal","embryos",",","mesectoderm","development","processes","give","rise","to","both","mesoderm","and","ectoderm","tissues","."),4102361). assertion_content_comment('tOboGo_MesencephalicTrigeminalNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesencephalic","trigeminal","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042821). assertion_content_comment('tOboGo_MesenchymalCellCondensationInvolvedInMammaryFatDevelopment',s("The","cell","adhesion","process","in","which","mammary","mesenchyme","cells","adhere","to","one","another","in","the","initial","stages","of","the","formation","of","mammary","fat","development","."),4112180). assertion_content_comment('tOboGo_MesenchymalCellDevelopment',s("The","process","aimed","at","the","progression","of","a","mesenchymal","cell","over","time",",","from","initial","commitment","of","the","cell","to","its","specific","fate",",","to","the","fully","functional","differentiated","cell","."),3984994). assertion_content_comment('tOboGo_MesenchymalCellDifferentiationInvolvedInKidneyDevelopment',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","mesenchymal","cells","of","the","kidney","as","it","progresses","from","its","formation","to","the","mature","state","."),4123240). assertion_content_comment('tOboGo_MesenchymalCellDifferentiationInvolvedInLungDevelopment',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesenchymal","cell","of","the","lung",".","A","mesenchymal","cell","is","a","loosely","associated","cell","that","is","part","of","the","connective","tissue","in","an","organism",".","Mesenchymal","cells","give","rise","to","more","mature","connective","tissue","cell","types","."),4114330). assertion_content_comment('tOboGo_MesenchymalCellDifferentiationInvolvedInMammaryGlandDevelopment',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mammary","gland","mesenchymal","cell",".","Mammary","gland","mesenchymal","cells","form","a","loosely","connected","network","of","cells","that","surround","the","mammary","ducts","."),4111796). assertion_content_comment('tOboGo_MesenchymalCellDifferentiationInvolvedInSalivaryGlandDevelopment',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesenchymal","cell","of","the","salivary","gland",".","A","mesenchymal","cell","is","a","loosely","associated","cell","that","is","part","of","the","connective","tissue","in","an","organism",".","Mesenchymal","cells","give","rise","to","more","mature","connective","tissue","cell","types","."),4160960). assertion_content_comment('tOboGo_MesenchymalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesenchymal","cell",".","A","mesenchymal","cell","is","a","loosely","associated","cell","that","is","part","of","the","connective","tissue","in","an","organism",".","Mesenchymal","cells","give","rise","to","more","mature","connective","tissue","cell","types","."),3984992). assertion_content_comment('tOboGo_MesenchymalCellFateCommitment',s("The","process","in","which","a","cell","becomes","committed","to","become","a","mesenchymal","cell","."),4039069). assertion_content_comment('tOboGo_MesenchymalCellMigrationInvolvedInLimbBudFormation',s("The","orderly","movement","of","a","mesenchymal","cell","from","one","site","to","another","that","will","contribute","to","the","formation","of","a","limb","bud","."),4071286). assertion_content_comment('tOboGo_MesenchymalCellProliferationInvolvedInLungDevelopment',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","mesenchymal","cell","population","that","contributes","to","the","progression","of","the","lung","over","time",".","A","mesenchymal","cell","is","a","cell","that","normally","gives","rise","to","other","cells","that","are","organized","as","three-dimensional","masses",",","rather","than","sheets","."),4114320). assertion_content_comment('tOboGo_MesenchymalCellProliferationInvolvedInProstateGlandDevelopment',s("The","multiplication","or","reproduction","of","mesenchymal","cells",",","resulting","in","the","expansion","of","a","cell","population","that","contributes","to","the","progression","of","the","prostate","gland","over","time","."),4110892). assertion_content_comment('tOboGo_MesenchymalCellProliferationInvolvedInUreterDevelopment',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","mesenchymal","cell","population","of","the","ureter",",","that","contributes","to","ureter","development","."),4124843). assertion_content_comment('tOboGo_MesenchymalCellProliferationInvolvedInUretericBudDevelopment',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","mesenchymal","cell","population","of","the","ureteric","bud",",","that","contributes","to","ureteric","bud","development","."),4122826). assertion_content_comment('tOboGo_MesenchymalCellProliferation',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","mesenchymal","cell","population",".","A","mesenchymal","cell","is","a","cell","that","normally","gives","rise","to","other","cells","that","are","organized","as","three-dimensional","masses",",","rather","than","sheets","."),3990401). assertion_content_comment('tOboGo_MesenchymalSmoothenedSignalingPathwayInvolvedInProstateGlandDevelopment',s("The","series","of","molecular","signals","generated","as","a","consequence","of","activation","of","the","transmembrane","Smoothened-type","protein","in","the","mesenchymal","cells","of","the","prostate","that","contribute","to","the","progression","of","the","prostate","over","time",".","This","process","contributes","to","lung","development","."),4110915). assertion_content_comment('tOboGo_MesenchymalStemCellDifferentiationInvolvedInMesonephricNephronMorphogenesis',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesenchymal","stem","cell","that","contributes","to","the","shaping","of","a","nephronin","the","mesonephros",".","A","mesenchymal","stem","cell","is","a","cell","that","retains","the","ability","to","divide","and","proliferate","throughout","life","to","provide","progenitor","cells","that","can","differentiate","into","specialized","mesenchymal","cells","."),4134187). assertion_content_comment('tOboGo_MesenchymalStemCellDifferentiationInvolvedInMetanephricNephronMorphogenesis',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesenchymal","stem","cell","that","contributes","to","the","shaping","of","a","nephronin","the","metanephros",".","A","mesenchymal","stem","cell","is","a","cell","that","retains","the","ability","to","divide","and","proliferate","throughout","life","to","provide","progenitor","cells","that","can","differentiate","into","specialized","mesenchymal","cells","."),4124354). assertion_content_comment('tOboGo_MesenchymalStemCellDifferentiationInvolvedInNephronMorphogenesis',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesenchymal","stem","cell","that","contributes","to","the","shaping","of","a","nephron",".","A","mesenchymal","stem","cell","is","a","cell","that","retains","the","ability","to","divide","and","proliferate","throughout","life","to","provide","progenitor","cells","that","can","differentiate","into","specialized","mesenchymal","cells","."),4123626). assertion_content_comment('tOboGo_MesenchymalStemCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesenchymal","stem","cell",".","A","mesenchymal","stem","cell","is","a","cell","that","retains","the","ability","to","divide","and","proliferate","throughout","life","to","provide","progenitor","cells","that","can","differentiate","into","specialized","mesenchymal","cells","."),4096690). assertion_content_comment('tOboGo_MesenchymalStemCellMaintenanceInvolvedInMesonephricNephronMorphogenesis',s("The","process","in","which","an","organism","retains","a","population","of","mesenchymal","stem","cells","that","contributes","to","the","shaping","of","a","nephron","in","the","mesonephros",".","A","mesenchymal","stem","cell","is","a","cell","that","retains","the","ability","to","divide","and","proliferate","throughout","life","to","provide","progenitor","cells","that","can","differentiate","into","specialized","mesenchymal","cells","."),4134031). assertion_content_comment('tOboGo_MesenchymalStemCellMaintenanceInvolvedInMetanephricNephronMorphogenesis',s("The","process","in","which","an","organism","retains","a","population","of","mesenchymal","stem","cells","that","contributes","to","the","shaping","of","a","nephron","in","the","metanephros",".","A","mesenchymal","stem","cell","is","a","cell","that","retains","the","ability","to","divide","and","proliferate","throughout","life","to","provide","progenitor","cells","that","can","differentiate","into","specialized","mesenchymal","cells","."),4124626). assertion_content_comment('tOboGo_MesenchymalStemCellMaintenanceInvolvedInNephronMorphogenesis',s("The","process","in","which","an","organism","retains","a","population","of","mesenchymal","stem","cells","that","contributes","to","the","shaping","of","a","nephron",".","A","mesenchymal","stem","cell","is","a","cell","that","retains","the","ability","to","divide","and","proliferate","throughout","life","to","provide","progenitor","cells","that","can","differentiate","into","specialized","mesenchymal","cells","."),4123567). assertion_content_comment('tOboGo_MesenchymalStemCellProliferationInvolvedInNephronMorphogenesis',s("The","multiplication","or","reproduction","of","mesenchymal","stem","cells",",","resulting","in","the","expansion","of","a","stem","cell","population",",","that","contributes","to","the","shaping","of","a","nephron","."),4123502). assertion_content_comment('tOboGo_MesenchymalToEpithelialTransitionInvolvedInMesonephricRenalVesicleFormation',s("A","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","that","will","contribute","to","the","shaping","of","the","mesonephric","renal","vesicle","."),4134525). assertion_content_comment('tOboGo_MesenchymalToEpithelialTransitionInvolvedInMesonephrosMorphogenesis',s("A","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","that","will","contribute","to","the","shaping","of","the","mesonephros","."),4134440). assertion_content_comment('tOboGo_MesenchymalToEpithelialTransitionInvolvedInMetanephricRenalVesicleFormation',s("A","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","that","will","contribute","to","the","shaping","of","the","metanephric","renal","vesicle","."),4124332). assertion_content_comment('tOboGo_MesenchymalToEpithelialTransitionInvolvedInMetanephrosMorphogenesis',s("A","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","that","will","contribute","to","the","shaping","of","the","metanephros","."),4006132). assertion_content_comment('tOboGo_MesenchymalToEpithelialTransitionInvolvedInRenalVesicleFormation',s("A","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","that","will","contribute","to","the","shaping","of","the","renal","vesicle","."),4124329). assertion_content_comment('tOboGo_MesenchymalToEpithelialTransition',s("A","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","."),4005995). assertion_content_comment('tOboGo_MesenchymeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","mesenchymal","tissue","over","time",",","from","its","formation","to","the","mature","structure",".","A","mesenchymal","tissue","is","made","up","of","loosely","packed","stellate","cells","."),3984989). assertion_content_comment('tOboGo_MesenchymeMigration',s("The","process","in","which","the","population","of","cells","that","make","up","a","mesenchyme","undergo","directed","movement","."),4071283). assertion_content_comment('tOboGo_MesenchymeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","mesenchymal","tissue","are","generated","and","organized",".","A","mesenchymal","tissue","is","made","up","of","loosely","packed","stellate","cells","."),4001132). assertion_content_comment('tOboGo_MesendodermDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesendoderm","over","time",",","from","its","formation","to","the","mature","structure",".","In","animal","embryos",",","mesendoderm","development","gives","rise","to","both","mesoderm","and","endoderm","tissues","."),4005630). assertion_content_comment('tOboGo_MesendodermMigration',s("The","process","in","which","the","population","of","cells","that","make","up","a","mesendoderm","undergo","directed","movement",".","The","mesendoderm","is","the","epithelial","tissue","that","gives","rise","to","both","mesoderm","and","endoderm","."),4005632). assertion_content_comment('tOboGo_MesodermalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","mesoderm","cell","."),3982071). assertion_content_comment('tOboGo_MesodermalCellFateCommitment',s("The","cell","differentiation","process","that","results","in","commitment","of","a","cell","to","become","part","of","the","mesoderm","."),3982092). assertion_content_comment('tOboGo_MesodermalCellFateDetermination',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","mesoderm","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4018251). assertion_content_comment('tOboGo_MesodermalCellFateSpecification',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","mesoderm","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4018263). assertion_content_comment('tOboGo_MesodermalCellMigration',s("The","orderly","movement","of","mesodermal","cells","from","one","site","to","another","."),4015146). assertion_content_comment('tOboGo_MesodermalToMesenchymalTransitionInvolvedInGastrulation',s("The","epithelial","to","mesenchymal","transition","process","in","which","a","mesodermal","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","as","part","of","the","process","of","gastrulation","."),4111081). assertion_content_comment('tOboGo_MesodermDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesoderm","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesoderm","is","the","middle","germ","layer","that","develops","into","muscle",",","bone",",","cartilage",",","blood","and","connective","tissue","."),3982065). assertion_content_comment('tOboGo_MesodermFormation',s("The","process","that","gives","rise","to","the","mesoderm",".","This","process","pertains","to","the","initial","formation","of","the","structure","from","unspecified","parts","."),3982069). assertion_content_comment('tOboGo_MesodermMigrationInvolvedInGastrulation',s("The","migration","of","mesodermal","cells","during","gastrulation","to","help","establish","the","multilayered","body","plan","of","the","organism","."),4015136). assertion_content_comment('tOboGo_MesodermMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","mesoderm","are","generated","and","organized","."),3982067). assertion_content_comment('tOboGo_MesodermStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","mesoderm",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4102078). assertion_content_comment('tOboGo_MesonephricCapsuleDevelopment',s("The","progression","of","the","mesonephric","capsule","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephric","capsule","is","the","tough","fibrous","layer","surrounding","the","mesonephros",",","covered","in","a","thick","layer","of","perinephric","adipose","tissue","."),4134554). assertion_content_comment('tOboGo_MesonephricCapsuleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","mesonephric","capsule","from","unspecified","parts",".","The","mesonephric","capsule","is","the","tough","fibrous","layer","surrounding","the","mesonephros",",","covered","in","a","thick","layer","of","perinephric","adipose","tissue",".","It","provides","some","protection","from","trauma","and","damage","."),4134566). assertion_content_comment('tOboGo_MesonephricCapsuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","mesonephric","capsule","are","generated","and","organized",".","The","mesonephric","capsule","is","the","tough","fibrous","layer","surrounding","the","mesonephros",",","covered","in","a","thick","layer","of","perinephric","adipose","tissue",".","It","provides","some","protection","from","trauma","and","damage","."),4134556). assertion_content_comment('tOboGo_MesonephricCapsuleSpecification',s("The","regionalization","process","in","which","the","identity","of","the","mesonephric","capsule","is","specified",".","Identity","is","considered","to","be","the","aggregate","of","characteristics","by","which","a","structure","is","recognized","."),4134576). assertion_content_comment('tOboGo_MesonephricCollectingDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","collecting","duct","in","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","collecting","duct","regulates","water",",","electrolyte","and","acid-base","balance",".","The","collecting","duct","is","the","final","common","path","through","which","urine","flows","before","entering","the","ureter","and","then","emptying","into","the","bladder","."),4136181). assertion_content_comment('tOboGo_MesonephricConnectingTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesonephric","connecting","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephric","connecting","tubule","is","a","tubular","segment","of","the","mesonephric","nephron",";","it","connects","the","distal","tubule","to","the","collecting","duct","in","the","mesonephros","."),4134630). assertion_content_comment('tOboGo_MesonephricDistalTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesonephric","distal","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephric","distal","tubule","is","a","mesonephric","nephron","tubule","that","begins","at","the","terminal","segment","of","the","proximal","tubule","and","ends","at","the","mesonephric","connecting","tubule","."),4134470). assertion_content_comment('tOboGo_MesonephricDistalTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","mesonephric","distal","tubule","are","generated","and","organized",".","The","mesonephric","distal","tubule","is","a","mesonephric","nephron","tubule","that","begins","at","the","macula","densa","and","extends","to","the","mesonephric","connecting","tubule","."),4134472). assertion_content_comment('tOboGo_MesonephricDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","mesonephric","duct","over","time",",","from","its","initial","formation","to","a","mature","structure",".","A","mesonephric","duct","is","a","tube","drains","the","mesonephros","."),4123419). assertion_content_comment('tOboGo_MesonephricDuctFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","mesonephric","duct",".","A","mesonephric","duct","is","a","tube","drains","the","mesonephros","."),4158181). assertion_content_comment('tOboGo_MesonephricDuctMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","mesonephric","duct","are","generated","and","organized",".","A","mesonephric","duct","is","a","tube","drains","the","mesonephros","."),4123430). assertion_content_comment('tOboGo_MesonephricEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","epithelium","in","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure",".","An","epithelium","is","a","tissue","that","covers","the","internal","or","external","surfaces","of","an","anatomical","structure","."),4123259). assertion_content_comment('tOboGo_MesonephricExtraglomerularMesangialCellProliferationInvolvedInMesonephrosDevelopment',s("The","multiplication","or","reproduction","of","extraglomerular","glomerular","mesangium","cells","in","the","mesonephros","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","Extraglomerular","mesangial","cells","(","also","known","as","lacis","cells",",","Goormaghtigh","cells",")","are","light-staining","cells","in","the","kidney","found","outside","the","glomerulus",",","near","the","vascular","pole","and","macula","densa","."),4133946). assertion_content_comment('tOboGo_MesonephricGlomerularBasementMembraneDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesonephric","glomerular","basement","membrane","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephric","glomerular","basement","membrane","is","the","basal","laminal","portion","of","the","mesonephric","glomerulus","which","performs","the","actual","filtration","."),4134134). assertion_content_comment('tOboGo_MesonephricGlomerularCapillaryFormation',s("The","process","that","gives","rise","to","a","mesonephric","glomerular","capillary",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4134345). assertion_content_comment('tOboGo_MesonephricGlomerularEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","mesonephric","glomerular","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Mesonephric","glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","mesonephric","glomerulus",";","there","are","two","types",",","mesonephric","glomerular","parietal","epithelial","cells","and","mesonephric","glomerular","visceral","epithelial","cells","."),4134299). assertion_content_comment('tOboGo_MesonephricGlomerularEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesonephric","glomerular","epithelial","cell",".","Mesonephric","glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","mesonephric","glomerulus",";","there","are","two","types",",","mesonephric","glomerular","parietal","epithelial","cells","and","mesonephric","glomerular","visceral","epithelial","cells","."),4134248). assertion_content_comment('tOboGo_MesonephricGlomerularEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","mesonephric","glomerular","epithelial","cell",".","Mesonephric","glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","mesonephric","glomerulus",";","there","are","two","types",",","mesonephric","glomerular","parietal","epithelial","cells","and","mesonephric","glomerular","visceral","epithelial","cells","."),4134268). assertion_content_comment('tOboGo_MesonephricGlomerularEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesonephric","glomerular","epithelium","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephric","glomerular","epithelium","is","an","epithelial","tissue","that","covers","the","outer","surfaces","of","the","glomerulus","in","the","mesonephros",".","The","mesonephric","glomerular","epithelium","consists","of","both","parietal","and","visceral","epithelium",".","Mesonephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport",".","A","mesonephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","mesonephros","."),4134145). assertion_content_comment('tOboGo_MesonephricGlomerularMesangialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","glomerular","mesangial","cell","in","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure","."),4134419). assertion_content_comment('tOboGo_MesonephricGlomerularMesangialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","glomerular","mesangial","cells","of","the","mesonephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4134335). assertion_content_comment('tOboGo_MesonephricGlomerularMesangialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","mesonephric","glomerular","mesangial","cell","."),4134409). assertion_content_comment('tOboGo_MesonephricGlomerularMesangialCellProliferationInvolvedInMesonephrosDevelopment',s("The","multiplication","or","reproduction","of","glomerular","mesangial","cells","in","the","mesonephros",",","resulting","in","the","expansion","of","the","population","."),4134536). assertion_content_comment('tOboGo_MesonephricGlomerularMesangiumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesonephric","glomerular","mesangium","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephric","glomerular","mesangium","is","the","thin","membrane","connective","tissue","composed","of","mesangial","cells","in","the","mesonephros",",","which","helps","to","support","the","capillary","loops","in","a","renal","glomerulus","."),4134165). assertion_content_comment('tOboGo_MesonephricGlomerularParietalEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","mesonephric","glomerular","parietal","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Mesonephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport","."),4134356). assertion_content_comment('tOboGo_MesonephricGlomerularParietalEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesonephric","glomerular","parietal","epithelial","cell",".","Mesonephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport","."),4134251). assertion_content_comment('tOboGo_MesonephricGlomerularParietalEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","mesonephric","glomerular","parietal","epithelial","cell",".","Mesonephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport",".","These","cells","may","also","give","rise","to","podocytes","."),4134272). assertion_content_comment('tOboGo_MesonephricGlomerularVisceralEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","mesonephric","glomerular","visceral","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","mesonephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","mesonephros","."),4134303). assertion_content_comment('tOboGo_MesonephricGlomerularVisceralEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","mesonephric","glomerular","visceral","epithelial","cell",".","A","mesonephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","mesonephros","."),4134282). assertion_content_comment('tOboGo_MesonephricGlomerularVisceralEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","mesonephric","glomerular","visceral","epithelial","cell",".","A","mesonephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","mesonephros","."),4134314). assertion_content_comment('tOboGo_MesonephricGlomerulusDevelopment',s("The","progression","of","the","mesonephric","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","mesonephric","glomerulus","is","a","capillary","tuft","which","forms","a","close","network","with","the","visceral","epithelium","(","podocytes",")","and","the","mesangium","to","form","the","filtration","barrier","and","is","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","mature","vertebrate","kidney",",","or","mesonephros","."),4134021). assertion_content_comment('tOboGo_MesonephricGlomerulusMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","mesonephric","glomerulus","are","generated","and","organized",".","The","mesonephric","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","mesonephros","."),4134052). assertion_content_comment('tOboGo_MesonephricGlomerulusVasculatureDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","mesonephric","glomerulus","vasculature","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","mesonephric","glomerulus","vasculature","and","ends","with","the","mature","structure",".","The","mesonephric","glomerulus","vasculature","is","composed","of","the","tubule","structures","that","carry","blood","or","lymph","in","the","mesonephric","glomerulus","."),4134114). assertion_content_comment('tOboGo_MesonephricGlomerulusVasculatureMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","mesonephric","glomerulus","vasculature","are","generated","and","organized",".","The","mesonephric","glomerulus","vasculature","is","composed","of","the","tubule","structures","that","carry","blood","or","lymph","in","the","mesonephric","glomerulus","."),4134176). assertion_content_comment('tOboGo_MesonephricInterstitialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","mesonephric","interstitial","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4134387). assertion_content_comment('tOboGo_MesonephricInterstitialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","interstitial","cells","of","the","mesonephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4134366). assertion_content_comment('tOboGo_MesonephricInterstitialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","mesonephric","interstitial","cell","."),4134377). assertion_content_comment('tOboGo_MesonephricIntraglomerularMesangialCellProliferation',s("The","multiplication","or","reproduction","of","intraglomerular","glomerular","mesangium","cells","in","the","mesonephros","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","Intraglomerular","mesangial","cells","are","specialized","pericytes","located","among","the","glomerular","capillaries","within","a","renal","corpuscle","of","a","kidney",".","They","are","required","for","filtration",",","structural","support","and","phagocytosis","."),4155905). assertion_content_comment('tOboGo_MesonephricJuxtaglomerularApparatusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","juxtaglomerular","apparatus","in","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","juxtaglomerular","apparatus","is","an","anatomical","structure","which","consists","of","juxtaglomerular","cells",",","extraglomerular","mesangial","cells","and","the","macula","densa",".","The","juxtaglomerular","apparatus","lies","adjacent","to","the","glomerulus","and","regulates","kidney","function","by","maintaining","the","blood","flow","to","the","kidney","and","the","filtration","rate","."),4134092). assertion_content_comment('tOboGo_MesonephricJuxtaglomerulusCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","mesonephric","juxtaglomerulus","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4134124). assertion_content_comment('tOboGo_MesonephricJuxtaglomerulusCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","juxtaglomerulus","cells","of","the","mesonephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4134094). assertion_content_comment('tOboGo_MesonephricJuxtaglomerulusCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","mesonephric","juxtaglomerulus","cell","."),4134104). assertion_content_comment('tOboGo_MesonephricMaculaDensaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesonephric","macula","densa","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephric","macula","densa","is","an","area","of","specialized","cells","in","the","distal","tubule","of","the","mesonephros","that","makes","contact","with","the","vascular","pole","of","the","glomerulus","."),4136191). assertion_content_comment('tOboGo_MesonephricMesangialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","mesangial","cells","of","the","mesonephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4134331). assertion_content_comment('tOboGo_MesonephricMesenchymalCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","mesenchymal","cells","of","the","mesonephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4133990). assertion_content_comment('tOboGo_MesonephricMesenchymalCellProliferationInvolvedInMesonephrosDevelopment',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","mesonephric","mesenchymal","cell","population","."),4134001). assertion_content_comment('tOboGo_MesonephricMesenchymeDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","mesonephric","mesenchyme","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","mesonephric","mesenchyme","and","ends","with","the","mature","structure",".","Mesonephric","mesenchyme","is","the","tissue","made","up","of","loosely","connected","mesenchymal","cells","in","the","mesonephros","."),4133979). assertion_content_comment('tOboGo_MesonephricMesenchymeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","mesonephric","mesenchymal","tissue","are","generated","and","organized",".","Mesonephric","mesenchyme","is","the","tissue","made","up","of","loosely","connected","mesenchymal","cells","in","the","mesonephros","."),4134011). assertion_content_comment('tOboGo_MesonephricNephronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","nephron","in","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure",".","A","nephron","is","the","functional","unit","of","the","kidney","."),4133902). assertion_content_comment('tOboGo_MesonephricNephronEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesonephric","nephron","epithelium","over","time",",","from","its","formation","to","the","mature","structure",".","An","epithelium","is","a","tissue","that","covers","the","internal","or","external","surfaces","of","an","anatomical","structure",".","The","mesonephric","nephron","epithelium","is","a","tissue","that","covers","the","surface","of","a","nephron","in","the","mesonephros","."),4134205). assertion_content_comment('tOboGo_MesonephricNephronMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","mesonephric","nephron","are","generated","and","organized",".","A","mesonephric","nephron","is","the","functional","unit","of","the","mesonephros","."),4133969). assertion_content_comment('tOboGo_MesonephricNephronTubuleDevelopment',s("The","progression","of","a","mesonephric","nephron","tubule","over","time",",","from","its","initial","formation","to","the","mature","structure",".","A","mesonephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","mesonephric","nephron",",","the","functional","part","of","the","mesonephros","."),4134209). assertion_content_comment('tOboGo_MesonephricNephronTubuleEpithelialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","cells","of","the","mesonephric","nephron","tubule","as","it","progresses","from","its","formation","to","the","mature","state","."),4134399). assertion_content_comment('tOboGo_MesonephricNephronTubuleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","mesonephric","nephron","tubule","from","unspecified","parts",".","A","mesonephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","a","nephron","in","the","mesonephros","."),4134493). assertion_content_comment('tOboGo_MesonephricNephronTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","mesonephric","nephron","tubule","are","generated","and","organized",".","A","mesonephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","mesonephric","nephron",",","the","functional","part","of","the","mesonephros","."),4134220). assertion_content_comment('tOboGo_MesonephricProximalTubuleDevelopment',s("The","progression","of","the","mesonephric","proximal","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephric","proximal","tubule","extends","from","the","capsule","to","the","distal","tubule","."),4134503). assertion_content_comment('tOboGo_MesonephricProximalTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","mesonephric","proximal","tubule","are","generated","and","organized",".","The","mesonephric","proximal","tubule","extends","from","the","capsule","to","the","distal","tubule","."),4134514). assertion_content_comment('tOboGo_MesonephricRenalVesicleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","mesonephros","."),4134429). assertion_content_comment('tOboGo_MesonephricRenalVesicleInduction',s("Signaling","at","short","range","between","cells","of","the","ureteric","bud","terminus","and","the","kidney","mesenchyme","that","positively","regulates","the","formation","of","the","mesonephric","renal","vesicle","."),4134665). assertion_content_comment('tOboGo_MesonephricRenalVesicleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","mesonephric","renal","vesicle","are","generated","and","organized",".","The","renal","vesicle","is","the","primordial","structure","of","the","mesonephric","nephron","epithelium",",","and","is","formed","by","the","condensation","of","mesenchymal","cells","."),4134230). assertion_content_comment('tOboGo_MesonephricSmoothMuscleTissueDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","smooth","muscle","in","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure","."),4136171). assertion_content_comment('tOboGo_MesonephricTubuleDevelopment',s("The","progression","of","a","mesonephric","tubule","over","time",",","from","its","initial","formation","to","the","mature","structure",".","A","mesonephric","tubule","is","an","epithelial","tube","that","is","part","of","the","mesonephros","."),4123297). assertion_content_comment('tOboGo_MesonephricTubuleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","mesonephric","tubule","from","unspecified","parts",".","A","mesonephric","tubule","is","an","epithelial","tube","that","is","part","of","the","mesonephros","."),4123334). assertion_content_comment('tOboGo_MesonephricTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","mesonephric","tubule","are","generated","and","organized",".","A","mesonephric","tubule","is","an","epithelial","tube","that","is","part","of","the","mesonephros","."),4123332). assertion_content_comment('tOboGo_MesonephrosDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure",".","In","mammals",",","the","mesonephros","is","the","second","of","the","three","embryonic","kidneys","to","be","established","and","exists","only","transiently",".","In","lower","vertebrates","such","as","fish","and","amphibia",",","the","mesonephros","will","form","the","mature","kidney","."),4123249). assertion_content_comment('tOboGo_MesonephrosMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","mesonephros","are","generated","and","organized","."),4133966). assertion_content_comment('tOboGo_Mesosome',s("An","intracellular",",","often","complex",",","membranous","structure",",","sometimes","with","additional","membranous","lamellae","inside",",","found","in","bacteria",".","They","are","associated","with","synthesis","of","DNA","and","secretion","of","proteins","."),4358428). assertion_content_comment('tOboGo_MetabolicProcessResultingInCellGrowth',s("OBSOLETE",".","The","chemical","reactions","that","occur","in","living","organisms","that","result","in","an","increase","in","the","mass","(","size",")","of","a","cell","."),4361385). assertion_content_comment('tOboGo_MetabolicProcess',s("The","chemical","reactions","and","pathways",",","including","anabolism","and","catabolism",",","by","which","living","organisms","transform","chemical","substances",".","Metabolic","processes","typically","transform","small","molecules",",","but","also","include","macromolecular","processes","such","as","DNA","repair","and","replication",",","and","protein","synthesis","and","degradation","."),3968934). assertion_content_comment('tOboGo_MetabolismByHostOfSubstanceInSymbiont',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","its","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110053). assertion_content_comment('tOboGo_MetabolismByHostOfSymbiontCarbohydrate',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","carbohydrates","within","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110079). assertion_content_comment('tOboGo_MetabolismByHostOfSymbiontCellWallCellulose',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","cellulose","in","the","cell","wall","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110092). assertion_content_comment('tOboGo_MetabolismByHostOfSymbiontCellWallChitin',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","chitin","in","the","cell","wall","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110204). assertion_content_comment('tOboGo_MetabolismByHostOfSymbiontCellWallPectin',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","pectin","in","the","cell","wall","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110156). assertion_content_comment('tOboGo_MetabolismByHostOfSymbiontGlucan',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","glucans","within","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188378). assertion_content_comment('tOboGo_MetabolismByHostOfSymbiontMacromolecule',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","macromolecules","within","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110066). assertion_content_comment('tOboGo_MetabolismByHostOfSymbiontProtein',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","protein","macromolecules","within","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188388). assertion_content_comment('tOboGo_MetabolismByHostOfSymbiontXylan',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","xylan","within","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188345). assertion_content_comment('tOboGo_MetabolismByOrganismOfCarbohydrateInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","carbohydrates","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109961). assertion_content_comment('tOboGo_MetabolismByOrganismOfCellWallCelluloseInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","cellulose","in","the","cell","wall","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4110002). assertion_content_comment('tOboGo_MetabolismByOrganismOfCellWallChitinInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","chitin","in","the","cell","wall","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4110187). assertion_content_comment('tOboGo_MetabolismByOrganismOfCellWallPectinInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","pectin","in","the","cell","wall","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4110137). assertion_content_comment('tOboGo_MetabolismByOrganismOfGlucanInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","glucans","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4188375). assertion_content_comment('tOboGo_MetabolismByOrganismOfProteinInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","protein","macromolecules","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4154411). assertion_content_comment('tOboGo_MetabolismByOrganismOfXylanInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","xylan","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4188342). assertion_content_comment('tOboGo_MetabolismBySymbiontOfHostCarbohydrate',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","carbohydrates","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121047). assertion_content_comment('tOboGo_MetabolismBySymbiontOfHostCellWallCellulose',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","cellulose","in","the","cell","wall","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121086). assertion_content_comment('tOboGo_MetabolismBySymbiontOfHostCellWallChitin',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","chitin","in","the","cell","wall","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121062). assertion_content_comment('tOboGo_MetabolismBySymbiontOfHostCellWallPectin',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","pectin","in","the","cell","wall","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121110). assertion_content_comment('tOboGo_MetabolismBySymbiontOfHostGlucan',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","glucans","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194864). assertion_content_comment('tOboGo_MetabolismBySymbiontOfHostMacromolecule',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","macromolecules","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121032). assertion_content_comment('tOboGo_MetabolismBySymbiontOfHostProtein',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","protein","macromolecules","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154414). assertion_content_comment('tOboGo_MetabolismBySymbiontOfHostXylan',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","xylan","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194842). assertion_content_comment('tOboGo_MetabolismBySymbiontOfSubstanceInHost',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121017). assertion_content_comment('tOboGo_MetabolismOfMacromoleculeInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","involving","macromolecules","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109946). assertion_content_comment('tOboGo_MetabolismOfSubstanceInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109931). assertion_content_comment('tOboGo_MetabotropicGABAReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","metabotropic","GABA","receptor","."),4323466). assertion_content_comment('tOboGo_MetabotropicGlutamateReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","metabotropic","glutamate","receptor",".","Metabotropic","glutamate","receptors","are","G-protein","coupled","receptors","that","bind","glutamate","and","exert","an","effect","through","the","regulation","of","enzyme","activity","."),4323497). assertion_content_comment('tOboGo_MetabotropicGlutamateReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","glutamate","binding","to","a","cell","surface","receptor","coupled","to","effectors","through","GTP-binding","proteins","."),4235665). assertion_content_comment('tOboGo_MetabotropicHistamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","metabotropic","histamine","receptor","."),4324418). assertion_content_comment('tOboGo_MetabotropicNucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","metabotropic","nucleotide","receptor","."),4324237). assertion_content_comment('tOboGo_MetabotropicSerotoninReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","metabotropic","serotonin","receptor","."),4324182). assertion_content_comment('tOboGo_MetalChelatingActivity',s("The","formation","of","bonds","from","two","or","more","atoms","within","the","same","ligand","to","a","metal","atom","in","complexes","in","which","the","metal","is","part","of","a","ring","."),4313992). assertion_content_comment('tOboGo_MetalClusterBinding',s("Interacting","selectively","and","non-covalently","with","a","cluster","of","atoms","including","both","metal","ions","and","nonmetal","atoms",",","usually","sulfur","and","oxygen",".","Examples","include","iron-sulfur","clusters","and","nickel-iron-sulfur","clusters","."),4283710). assertion_content_comment('tOboGo_MetalIonBinding',s("Interacting","selectively","and","non-covalently","with","any","metal","ion","."),4079821). assertion_content_comment('tOboGo_MetalIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","metal","ions","within","an","organism","or","cell","."),4011650). assertion_content_comment('tOboGo_MetalIon_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","metal","ion","(","in",")","+","H","+","(","out",")","=","metal","ion","(","out",")","+","H","+","(","in",")"),4287338). assertion_content_comment('tOboGo_MetalIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","metal","ions","from","one","side","of","a","membrane","to","the","other","."),4178482). assertion_content_comment('tOboGo_MetalIonTransport',s("The","directed","movement","of","metal","ions",",","any","metal","ion","with","an","electric","charge",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3991128). assertion_content_comment('tOboGo_MetalloaminopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","N-terminal","amino","acid","residues","from","a","polypeptide","chain","by","a","mechanism","in","which","water","acts","as","a","nucleophile",",","one","or","two","metal","ions","hold","the","water","molecule","in","place",",","and","charged","amino","acid","side","chains","are","ligands","for","the","metal","ions","."),4180843). assertion_content_comment('tOboGo_MetallocarboxypeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","C-terminal","amino","acid","residues","from","a","polypeptide","chain","by","a","mechanism","in","which","water","acts","as","a","nucleophile",",","one","or","two","metal","ions","hold","the","water","molecule","in","place",",","and","charged","amino","acid","side","chains","are","ligands","for","the","metal","ions","."),4209827). assertion_content_comment('tOboGo_MetallocarboxypeptidaseDActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","peptidyl-L-lysine","(","or","peptidyl-L-arginine",")","+","H2O","=","peptide","+","L-lysine","(","or","L-arginine",")","Function","is","activated","by","Co2","+",";","inhibited","by","guanidinoethylmercaptosuccinic","acid","."),4254221). assertion_content_comment('tOboGo_MetallochaperoneActivity',s("Assists","in","the","delivery","of","metal","ions","to","target","proteins","or","compartments","."),4305105). assertion_content_comment('tOboGo_MetallodipeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","a","dipeptide","by","a","mechanism","in","which","water","acts","as","a","nucleophile",",","one","or","two","metal","ions","hold","the","water","molecule","in","place",",","and","charged","amino","acid","side","chains","are","ligands","for","the","metal","ions","."),4175226). assertion_content_comment('tOboGo_MetalloendopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","internal",",","alpha-peptide","bonds","in","a","polypeptide","chain","by","a","mechanism","in","which","water","acts","as","a","nucleophile",",","one","or","two","metal","ions","hold","the","water","molecule","in","place",",","and","charged","amino","acid","side","chains","are","ligands","for","the","metal","ions","."),4209855). assertion_content_comment('tOboGo_MetalloendopeptidaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","metalloendopeptidases",",","enzymes","that","catalyze","the","hydrolysis","of","nonterminal","peptide","bonds","in","a","polypeptide","chain","and","contain","a","chelated","metal","ion","at","their","active","sites","which","is","essential","to","their","catalytic","activity","."),4246088). assertion_content_comment('tOboGo_MetalloenzymeActivatorActivity',s("Increases","the","activity","of","a","metalloenzyme",".","A","metalloenzyme","is","any","enzyme","that","contains","metal","."),4336159). assertion_content_comment('tOboGo_MetalloenzymeInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","metalloenzyme",".","A","metalloenzyme","is","any","enzyme","that","contains","metal","."),4246086). assertion_content_comment('tOboGo_MetalloenzymeRegulatorActivity',s("Modulates","the","activity","of","a","metalloenzyme",".","A","metalloenzyme","is","any","enzyme","that","contains","metal","."),4246084). assertion_content_comment('tOboGo_MetalloexopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","a","peptide","bond","not","more","than","three","residues","from","the","N-","or","C-terminus","of","a","polypeptide","chain","by","a","mechanism","in","which","water","acts","as","a","nucleophile",",","one","or","two","metal","ions","hold","the","water","molecule","in","place",",","and","charged","amino","acid","side","chains","are","ligands","for","the","metal","ions","."),4175213). assertion_content_comment('tOboGo_MetallopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","peptide","bonds","by","a","mechanism","in","which","water","acts","as","a","nucleophile",",","one","or","two","metal","ions","hold","the","water","molecule","in","place",",","and","charged","amino","acid","side","chains","are","ligands","for","the","metal","ions","."),4175208). assertion_content_comment('tOboGo_Metamorphosis',s("A","biological","process","in","which","an","animal","physically","develops","after","birth","or","hatching",",","involving","a","conspicuous","and","relatively","abrupt","change","in","the","animal","'","s","form","or","structure",".","Examples","include","the","change","from","tadpole","to","frog",",","and","the","change","from","larva","to","adult",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),3982535). assertion_content_comment('tOboGo_MetanephricAscendingThinLimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","metanephric","ascending","thin","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","ascending","thin","limb","is","a","segment","of","a","nephron","tubule","in","the","metanephros","lying","in","the","inner","medulla","that","is","permeable","to","ions","but","not","to","water","and","has","a","simple","epithelium",";","active","transepithelial","solute","transport","is","absent","."),4124982). assertion_content_comment('tOboGo_MetanephricCapDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","the","metanephric","cap","from","an","initial","condition","to","its","mature","state",".","The","metanephric","cap","is","formed","by","the","condensation","of","metanephric","mesenchymal","cells","surrounding","the","ureteric","bud","tip","."),4124950). assertion_content_comment('tOboGo_MetanephricCapFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","metanephric","cap","from","unspecified","parts",".","The","metanephric","cap","is","formed","by","the","condensation","of","metanephric","mesenchymal","cells","surrounding","the","ureteric","bud","tip","."),4124962). assertion_content_comment('tOboGo_MetanephricCapMesenchymalCellProliferationInvolvedInMetanephrosDevelopment',s("The","multiplication","or","reproduction","of","metanephric","cap","mesenchymal","cells",",","resulting","in","the","expansion","of","the","cell","population",".","A","metanephric","cap","mesenchymal","cell","is","a","mesenchymal","cell","that","has","condensed","with","other","mesenchymal","cells","surrounding","the","ureteric","bud","tip","."),4150202). assertion_content_comment('tOboGo_MetanephricCapMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","metanephric","cap","are","generated","and","organized",".","The","metanephric","cap","is","formed","by","the","condensation","of","metanephric","mesenchymal","cells","surrounding","the","ureteric","bud","tip","."),4124952). assertion_content_comment('tOboGo_MetanephricCapSpecification',s("The","process","in","which","the","metanephric","cap","acquires","its","identity","."),4158191). assertion_content_comment('tOboGo_MetanephricCapsuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","capsule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","capsule","is","the","tough","fibrous","layer","surrounding","the","metanephros",",","covered","in","a","thick","layer","of","perinephric","adipose","tissue",".","It","provides","some","protection","from","trauma","and","damage","."),4124051). assertion_content_comment('tOboGo_MetanephricCapsuleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","metanephric","capsule","from","unspecified","parts",".","The","metanephric","capsule","is","the","tough","fibrous","layer","surrounding","the","metanephros",",","covered","in","a","thick","layer","of","perinephric","adipose","tissue",".","It","provides","some","protection","from","trauma","and","damage","."),4124055). assertion_content_comment('tOboGo_MetanephricCapsuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","metanephric","capsule","are","generated","and","organized",".","The","metanephric","capsule","is","the","tough","fibrous","layer","surrounding","the","metanephros",",","covered","in","a","thick","layer","of","perinephric","adipose","tissue",".","It","provides","some","protection","from","trauma","and","damage","."),4124053). assertion_content_comment('tOboGo_MetanephricCapsuleSpecification',s("The","regionalization","process","in","which","the","identity","of","the","metanephric","capsule","is","specified",".","Identity","is","considered","to","be","the","aggregate","of","characteristics","by","which","a","structure","is","recognized","."),4124065). assertion_content_comment('tOboGo_MetanephricCollectingDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","collecting","duct","in","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","collecting","duct","responds","to","vasopressin","and","aldosterone","to","regulate","water",",","electrolyte","and","acid-base","balance",".","The","collecting","duct","is","the","final","common","path","through","which","urine","flows","before","entering","the","ureter","and","then","emptying","into","the","bladder","."),4125002). assertion_content_comment('tOboGo_MetanephricConnectingTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","connecting","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","connecting","tubule","is","a","tubular","segment","of","the","metanephric","nephron",";","it","connects","the","distal","convoluted","tubule","to","the","collecting","duct","in","the","metanephros","."),4124713). assertion_content_comment('tOboGo_MetanephricCortexDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","cortex","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","cortex","is","the","outer","region","of","the","metanephros","."),4125022). assertion_content_comment('tOboGo_MetanephricCorticalCollectingDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","cortical","collecting","duct","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","cortical","collecting","duct","is","the","portion","of","the","metanephric","collecting","duct","that","resides","in","the","renal","cortex","."),4125012). assertion_content_comment('tOboGo_MetanephricDCTCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","metanephric","distal","convoluted","tubule","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4125408). assertion_content_comment('tOboGo_MetanephricDCTCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","distal","convoluted","tubule","cells","of","the","metanephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4125363). assertion_content_comment('tOboGo_MetanephricDCTCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","metanephric","distal","convoluted","tubule","cell","."),4125374). assertion_content_comment('tOboGo_MetanephricDescendingThinLimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","descending","thin","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","descending","thin","limb","is","a","part","of","the","metanephric","loop","of","Henle","situated","just","after","the","proximal","straight","tubule","(","S3",")","It","extends","to","the","tip","of","the","metanephric","loop","of","Henle","."),4124992). assertion_content_comment('tOboGo_MetanephricDistalConvolutedTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","distal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","distal","convoluted","tubule","is","a","portion","of","the","metanephric","nephron","tubule","that","connects","the","metanephric","loop","of","Henle","to","the","collecting","duct","."),4125204). assertion_content_comment('tOboGo_MetanephricDistalTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","distal","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","distal","tubule","is","a","metanephric","nephron","tubule","that","begins","at","the","metanephric","macula","densa","and","extends","to","the","metanephric","connecting","tubule","."),4124418). assertion_content_comment('tOboGo_MetanephricDistalTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","metanephric","distal","tubule","are","generated","and","organized",".","The","metanephric","distal","tubule","is","a","metanephric","nephron","tubule","that","begins","at","the","macula","densa","and","extends","to","the","metanephric","connecting","tubule","."),4124429). assertion_content_comment('tOboGo_MetanephricEarlyDistalConvolutedTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","early","distal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","early","distal","convoluted","tubule","contains","metanephric","DCT","cells","and","is","vasopressin-insensitive","."),4125234). assertion_content_comment('tOboGo_MetanephricEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","epithelium","in","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","An","epithelium","is","a","tissue","that","covers","the","internal","or","external","surfaces","of","an","anatomical","structure","."),4124210). assertion_content_comment('tOboGo_MetanephricExtraglomerularMesangialCellProliferationInvolvedInMetanephrosDevelopment',s("The","multiplication","or","reproduction","of","extraglomerular","glomerular","mesangium","cells","in","the","metanephros","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","Extraglomerular","mesangial","cells","(","also","known","as","lacis","cells",",","Goormaghtigh","cells",")","are","light-staining","cells","in","the","kidney","found","outside","the","glomerulus",",","near","the","vascular","pole","and","macula","densa","."),4124288). assertion_content_comment('tOboGo_MetanephricGlomerularBasementMembraneDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","glomerular","basement","membrane","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","glomerular","basement","membrane","is","the","basal","laminal","portion","of","the","metanephric","glomerulus","which","performs","the","actual","filtration","."),4124439). assertion_content_comment('tOboGo_MetanephricGlomerularCapillaryFormation',s("The","process","that","gives","rise","to","a","metanephric","glomerular","capillary",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4124504). assertion_content_comment('tOboGo_MetanephricGlomerularEndotheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","glomerular","endothelium","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","glomerular","endothelium","is","an","epithelial","tissue","that","covers","the","internal","surfaces","of","the","glomerulus","of","the","metanephros","."),4124107). assertion_content_comment('tOboGo_MetanephricGlomerularEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","metanephric","glomerular","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Metanephric","glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","metanephric","glomerulus",";","there","are","two","types",",","metanephric","glomerular","parietal","epithelial","cells","and","metanephric","glomerular","visceral","epithelial","cells","."),4124823). assertion_content_comment('tOboGo_MetanephricGlomerularEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","metanephric","glomerular","epithelial","cell",".","Metanephric","glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","metanephric","glomerulus",";","there","are","two","types",",","metanephric","glomerular","parietal","epithelial","cells","and","metanephric","glomerular","visceral","epithelial","cells","."),4124813). assertion_content_comment('tOboGo_MetanephricGlomerularEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","metanephric","glomerular","epithelial","cell",".","Metanephric","glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","metanephric","glomerulus",";","there","are","two","types",",","metanephric","glomerular","parietal","epithelial","cells","and","metanephric","glomerular","visceral","epithelial","cells","."),4125302). assertion_content_comment('tOboGo_MetanephricGlomerularEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","glomerular","epithelium","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","glomerular","epithelium","is","an","epithelial","tissue","that","covers","the","outer","surfaces","of","the","glomerulus","in","the","metanephros",".","The","metanephric","glomerular","epithelium","consists","of","both","parietal","and","visceral","epithelium",".","Metanephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport",".","A","metanephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","metanephros","."),4124811). assertion_content_comment('tOboGo_MetanephricGlomerularMesangialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","glomerular","mesangial","cell","in","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure","."),4125275). assertion_content_comment('tOboGo_MetanephricGlomerularMesangialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","glomerular","mesangial","cells","of","the","metanephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4124256). assertion_content_comment('tOboGo_MetanephricGlomerularMesangialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","metanephric","glomerular","mesangial","cell","."),4124266). assertion_content_comment('tOboGo_MetanephricGlomerularMesangialCellProliferationInvolvedInMetanephrosDevelopment',s("The","multiplication","or","reproduction","of","glomerular","mesangial","cells","in","the","metanephros",",","resulting","in","the","expansion","of","the","population","."),4124277). assertion_content_comment('tOboGo_MetanephricGlomerularMesangiumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","glomerular","mesangium","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","glomerular","mesangium","is","the","thin","membrane","connective","tissue","composed","of","mesangial","cells","in","the","metanephros",",","which","helps","to","support","the","capillary","loops","in","a","renal","glomerulus","."),4124254). assertion_content_comment('tOboGo_MetanephricGlomerularParietalEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","metanephric","glomerular","parietal","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Metanephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport","."),4125397). assertion_content_comment('tOboGo_MetanephricGlomerularParietalEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","metanephric","glomerular","parietal","epithelial","cell",".","Metanephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport","."),4125285). assertion_content_comment('tOboGo_MetanephricGlomerularParietalEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","metanephric","glomerular","parietal","epithelial","cell",".","Metanephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport",".","These","cells","may","also","give","rise","to","podocytes","."),4125305). assertion_content_comment('tOboGo_MetanephricGlomerularVisceralEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","metanephric","glomerular","visceral","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","metanephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","metanephros","."),4125339). assertion_content_comment('tOboGo_MetanephricGlomerularVisceralEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","metanephric","glomerular","visceral","epithelial","cell",".","A","metanephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","metanephros","."),4125316). assertion_content_comment('tOboGo_MetanephricGlomerularVisceralEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","metanephric","glomerular","visceral","epithelial","cell",".","A","metanephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","metanephros","."),4125351). assertion_content_comment('tOboGo_MetanephricGlomerulusDevelopment',s("The","progression","of","the","metanephric","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","metanephric","glomerulus","is","a","capillary","tuft","which","forms","a","close","network","with","the","visceral","epithelium","(","podocytes",")","and","the","mesangium","to","form","the","filtration","barrier","and","is","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","mature","vertebrate","kidney",",","or","metanephros","."),4124083). assertion_content_comment('tOboGo_MetanephricGlomerulusMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","metanephric","glomerulus","are","generated","and","organized",".","The","metanephric","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney",",","or","metanephros","."),4124458). assertion_content_comment('tOboGo_MetanephricGlomerulusVasculatureDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","metanephric","glomerulus","vasculature","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","metanephric","glomerulus","vasculature","and","ends","with","the","mature","structure",".","The","metanephric","glomerulus","vasculature","is","composed","of","the","tubule","structures","that","carry","blood","or","lymph","in","the","metanephric","glomerulus","."),4124086). assertion_content_comment('tOboGo_MetanephricGlomerulusVasculatureMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","metanephric","glomerulus","vasculature","are","generated","and","organized",".","The","metanephric","glomerulus","vasculature","is","composed","of","the","tubule","structures","that","carry","blood","or","lymph","in","the","metanephric","glomerulus","."),4124460). assertion_content_comment('tOboGo_MetanephricInterstitialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","metanephric","interstitial","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4124182). assertion_content_comment('tOboGo_MetanephricInterstitialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","interstitial","cells","of","the","metanephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4124171). assertion_content_comment('tOboGo_MetanephricInterstitialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","metanephric","interstitial","cell","."),4124300). assertion_content_comment('tOboGo_MetanephricIntraglomerularMesangialCellProliferation',s("The","multiplication","or","reproduction","of","intraglomerular","glomerular","mesangium","cells","in","the","metanephros","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","Intraglomerular","mesangial","cells","are","specialized","pericytes","located","among","the","glomerular","capillaries","within","a","renal","corpuscle","of","a","kidney",".","They","are","required","for","filtration",",","structural","support","and","phagocytosis","."),4158201). assertion_content_comment('tOboGo_MetanephricJuxtaglomerularApparatusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","juxtaglomerular","apparatus","in","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","juxtaglomerular","apparatus","is","an","anatomical","structure","which","consists","of","juxtaglomerular","cells",",","extraglomerular","mesangial","cells","and","the","macula","densa",".","The","juxtaglomerular","apparatus","lies","adjacent","to","the","glomerulus","and","regulates","kidney","function","by","maintaining","the","blood","flow","to","the","kidney","and","the","filtration","rate","."),4125077). assertion_content_comment('tOboGo_MetanephricJuxtaglomerulusCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","metanephric","juxtaglomerulus","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4125255). assertion_content_comment('tOboGo_MetanephricJuxtaglomerulusCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","juxtaglomerulus","cells","of","the","metanephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4125245). assertion_content_comment('tOboGo_MetanephricJuxtaglomerulusCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","metanephric","juxtaglomerulus","cell","."),4125265). assertion_content_comment('tOboGo_MetanephricLateDistalConvolutedTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","late","distal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","late","distal","convoluted","tubule","contains","metanephric","DCT","cells","and","intercalated","(","IC",")","alpha","and","beta","cells","and","is","vasopressin-sensitive","."),4125214). assertion_content_comment('tOboGo_MetanephricLongDescendingThinLimbBendDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","long","descending","thin","limb","bend","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","long","descending","thin","limb","bend","is","a","part","of","the","descending","thin","limb","of","a","long","nephron","that","lies","beyond","the","prebend","segment","in","the","metanephros","."),4125173). assertion_content_comment('tOboGo_MetanephricLongDescendingThinLimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","long","descending","thin","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","long","descending","thin","limb","is","the","descending","thin","limb","of","a","long","nephron","in","the","metanephros","that","has","a","squamous","epithelial","morphology",".","The","long","descending","limb","starts","in","the","inner","stripe","of","the","outer","medulla","and","extends","into","the","inner","medulla","."),4124148). assertion_content_comment('tOboGo_MetanephricLongNephronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","metanephric","long","nephron","over","time",",","from","its","formation","to","the","mature","structure",".","Long","nephrons","are","associated","with","juxtamedullary","glomeruli","and","extend","into","the","inner","medulla","in","the","metanephros","."),4124137). assertion_content_comment('tOboGo_MetanephricLoopOfHenleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","loop","of","Henle","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","loop","of","Henle","is","a","metanephric","nephron","tubule","that","connects","the","proximal","convoluted","tubule","to","the","distal","convoluted","tubule","in","the","metanephros","."),4124746). assertion_content_comment('tOboGo_MetanephricMaculaDensaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","macula","densa","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","macula","densa","is","an","area","of","specialized","cells","in","the","distal","tubule","of","the","metanephros","that","makes","contact","with","the","vascular","pole","of","the","glomerulus","."),4125194). assertion_content_comment('tOboGo_MetanephricMesangialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","mesangial","cells","of","the","metanephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4124243). assertion_content_comment('tOboGo_MetanephricMesenchymalCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","mesenchymal","cells","of","the","metanephros","as","it","progresses","from","its","formation","to","the","mature","state","."),4123280). assertion_content_comment('tOboGo_MetanephricMesenchymalCellMigration',s("The","orderly","movement","of","undifferentiated","metanephric","mesenchymal","cells","(","precursors","to","metanephric","mesangial","cells",")","from","the","mesenchyme","into","the","cleft","of","the","developing","glomerulus",",","during","development","of","the","metanephros","."),4144520). assertion_content_comment('tOboGo_MetanephricMesenchymalCellProliferationInvolvedInMetanephrosDevelopment',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","metanephric","mesenchymal","cell","population","."),4122859). assertion_content_comment('tOboGo_MetanephricMesenchymeDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","metanephric","mesenchyme","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","metanephric","mesenchyme","and","ends","with","the","mature","structure",".","Metanephric","mesenchyme","is","the","tissue","made","up","of","loosely","connected","mesenchymal","cells","in","the","metanephros","."),4122776). assertion_content_comment('tOboGo_MetanephricMesenchymeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","metanephric","mesenchymal","tissue","are","generated","and","organized",".","Metanephric","mesenchyme","is","the","tissue","made","up","of","loosely","connected","mesenchymal","cells","in","the","metanephros","."),4122796). assertion_content_comment('tOboGo_MetanephricNephronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","nephron","in","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","A","nephron","is","the","functional","unit","of","the","kidney","."),4006126). assertion_content_comment('tOboGo_MetanephricNephronEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","nephron","epithelium","over","time",",","from","its","formation","to","the","mature","structure",".","An","epithelium","is","a","tissue","that","covers","the","internal","or","external","surfaces","of","an","anatomical","structure",".","The","metanephric","nephron","epithelium","is","a","tissue","that","covers","the","surface","of","a","nephron","in","the","metanephros","."),4124212). assertion_content_comment('tOboGo_MetanephricNephronMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","metanephric","nephron","are","generated","and","organized",".","A","metanephric","nephron","is","the","functional","unit","of","the","metanephros","."),4006128). assertion_content_comment('tOboGo_MetanephricNephronTubuleDevelopment',s("The","progression","of","a","metanephric","nephron","tubule","over","time",",","from","its","initial","formation","to","the","mature","structure",".","A","metanephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","metanephric","nephron",",","the","functional","part","of","the","metanephros","."),4124214). assertion_content_comment('tOboGo_MetanephricNephronTubuleEpithelialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","cells","of","the","metanephric","nephron","tubule","as","it","progresses","from","its","formation","to","the","mature","state","."),4124225). assertion_content_comment('tOboGo_MetanephricNephronTubuleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","metanephric","nephron","tubule","from","unspecified","parts",".","A","metanephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","a","nephron","in","the","metanephros","."),4124397). assertion_content_comment('tOboGo_MetanephricNephronTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","metanephric","nephron","tubule","are","generated","and","organized",".","A","metanephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","metanephric","nephron",",","the","functional","part","of","the","metanephros","."),4124366). assertion_content_comment('tOboGo_MetanephricPrebendSegmentDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","prebend","segment","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","prebend","segment","is","a","part","of","the","metanephric","descending","thin","limb","that","lies","before","the","bend","and","exhibits","permeabilities","characteristic","of","the","ascending","limb",",","especially","negligible","water","permeability","."),4125224). assertion_content_comment('tOboGo_MetanephricProximalConvolutedTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","proximal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","proximal","convoluted","tubule","is","the","most","proximal","portion","of","the","metanephric","proximal","tubule","and","extends","from","the","metanephric","glomerular","capsule","to","the","metanephric","proximal","straight","tubule","."),4125087). assertion_content_comment('tOboGo_MetanephricProximalStraightTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","proximal","straight","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","proximal","straight","tubule","is","the","part","of","the","metanephric","descending","limb","that","extends","from","the","metanephric","proximal","convoluted","tubule","to","the","metanephric","descending","thin","tubule","."),4125118). assertion_content_comment('tOboGo_MetanephricProximalTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","proximal","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","proximal","tubule","is","a","metanephric","nephron","tubule","that","connects","Bowman","'","s","capsule","to","the","descending","thin","limb","of","the","loop","of","Henle","in","the","metanephros",".","It","has","a","brush","border","epithelial","morphology","."),4124376). assertion_content_comment('tOboGo_MetanephricProximalTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","metanephric","proximal","tubule","are","generated","and","organized",".","The","metanephric","proximal","tubule","is","a","metanephric","nephron","tubule","that","connects","Bowman","'","s","capsule","to","the","descending","thin","limb","of","the","loop","of","Henle","in","the","metanephros",".","It","has","a","brush","border","epithelial","morphology","."),4124387). assertion_content_comment('tOboGo_MetanephricPyramidsDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","pyramids","over","time",",","from","their","formation","to","the","mature","structures",".","Metanephric","pyramids","are","the","conical","masses","that","constitute","the","renal","medulla","in","a","metanephros",";","they","contain","the","loops","of","Henle","and","the","medullary","collecting","ducts","."),4125042). assertion_content_comment('tOboGo_MetanephricRenalVesicleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","metanephros","."),4123909). assertion_content_comment('tOboGo_MetanephricRenalVesicleInduction',s("Signaling","at","short","range","between","cells","of","the","ureteric","bud","terminus","and","the","kidney","mesenchyme","that","positively","regulates","the","formation","of","the","metanephric","renal","vesicle","."),4123969). assertion_content_comment('tOboGo_MetanephricRenalVesicleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","metanephric","renal","vesicle","are","generated","and","organized",".","The","renal","vesicle","is","the","primordial","structure","of","the","metanephric","nephron","epithelium",",","and","is","formed","by","the","condensation","of","mesenchymal","cells","."),4006130). assertion_content_comment('tOboGo_MetanephricS1Development',s("The","process","whose","specific","outcome","is","the","progression","of","the","S1","portion","of","the","metanephric","proximal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","S1","portion","is","the","initial","portion","of","the","metanephric","proximal","convoluted","tubule","and","is","responsible","for","avid","reabsorption","of","water","and","solutes","."),4125097). assertion_content_comment('tOboGo_MetanephricS2Development',s("The","process","whose","specific","outcome","is","the","progression","of","the","S2","portion","of","the","metanephric","proximal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","S2","portion","of","the","metanephric","proximal","tubule","is","involved","in","reabsorption","of","water","and","sodium","chloride","."),4125162). assertion_content_comment('tOboGo_MetanephricShortDescendingThinLimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","short","descending","thin","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","short","descending","thin","limb","is","the","descending","thin","limb","of","a","short","nephron","in","the","metanephros","that","has","a","squamous","epithelial","morphology","."),4124127). assertion_content_comment('tOboGo_MetanephricShortNephronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","short","nephron","in","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","Short","nephrons","are","associated","with","mid-cortical","and","superficial","glomeruli",",","are","situated","entirely","in","the","outer","medulla",",","and","have","no","thin","ascending","limb","."),4124117). assertion_content_comment('tOboGo_MetanephricSmoothMuscleTissueDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","smooth","muscle","in","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure","."),4125056). assertion_content_comment('tOboGo_MetanephricThickAscendingLimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephric","thick","ascending","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephric","thick","ascending","limb","is","the","last","part","of","the","metanephric","loop","of","Henle",".","Its","thick",",","mitochondria-rich","epithelium","characterizes","the","outer","medulla",",","and","is","responsible","for","very","avid","active","salt","transport",".","At","the","macula","densa",",","the","thick","ascending","limb","connects","to","the","distal","convoluted","tubule","."),4125141). assertion_content_comment('tOboGo_MetanephricTubuleDevelopment',s("The","progression","of","a","metanephric","tubule","over","time",",","from","its","initial","formation","to","the","mature","structure",".","A","metanephric","tubule","is","an","epithelial","tube","that","is","part","of","the","metanephros","."),4123349). assertion_content_comment('tOboGo_MetanephricTubuleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","metanephric","tubule","."),4123388). assertion_content_comment('tOboGo_MetanephricTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","metanephric","tubule","are","generated","and","organized","from","an","epithelium",".","A","metanephric","tubule","is","an","epithelial","tube","that","is","part","of","the","metanephros","."),4123378). assertion_content_comment('tOboGo_MetanephricUretericBudDevelopment',s("The","development","of","the","portion","of","the","ureteric","bud","tube","that","contributes","to","the","morphogenesis","of","the","metanephros","."),4084333). assertion_content_comment('tOboGo_MetanephrosDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","In","mammals",",","the","metanephros","is","the","excretory","organ","of","the","fetus",",","which","develops","into","the","mature","kidney","and","is","formed","from","the","rear","portion","of","the","nephrogenic","cord",".","The","metanephros","is","an","endocrine","and","metabolic","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4006113). assertion_content_comment('tOboGo_MetanephrosMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","metanephros","are","generated","and","organized","."),4006115). assertion_content_comment('tOboGo_MetaphaseChromosome',s("OBSOLETE",".","A","chromosome","found","in","the","cell","during","metaphase",".","Typically",",","sister","chromatids","are","held","together","at","their","centromeres","and","chromosomes","are","covered","with","a","large","number","of","molecules",",","including","ribonucleoproteins","."),4219729). assertion_content_comment('tOboGo_MetaphasePlateCongression',s("The","alignment","of","chromosomes","at","the","metaphase","plate",",","a","plane","halfway","between","the","poles","of","the","spindle","."),4012609). assertion_content_comment('tOboGo_MetaphasePlate',s("The","intracellular","plane",",","located","halfway","between","the","poles","of","the","spindle",",","where","chromosomes","align","during","metaphase","of","mitotic","or","meiotic","nuclear","division","."),4180256). assertion_content_comment('tOboGo_Metaphase',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","metaphase",",","the","second","stage","of","chromosome","segregation","in","the","cell","cycle",".","Canonically",",","chromosomes","become","aligned","on","the","equatorial","plate","of","the","cell","."),3971219). assertion_content_comment('tOboGo_MetarhodopsinBinding',s("Interacting","selectively","and","non-covalently","with","metarhodopsin",",","a","transient","intermediate","produced","upon","irradiation","of","rhodopsin","in","the","visual","cycle","and","existing","in","two","forms",",","metarhodopsins","I","and","II",".","The","latter","dissociates","to","form","opsin","and","all-trans","retinal","."),4302651). assertion_content_comment('tOboGo_MetarhodopsinInactivation',s("The","process","in","which","metarhodopsin","is","prevented","from","generating","molecular","signals","."),4033787). assertion_content_comment('tOboGo_Metaxin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4272935). assertion_content_comment('tOboGo_MetaxylemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metaxylem","over","time",",","from","its","formation","to","the","mature","structure",".","The","metaxylem","is","the","part","of","the","primary","xylem","that","differentiates","after","the","protoxylem","and","before","the","secondary","xylem",",","if","any","of","the","latter","is","formed","."),4150052). assertion_content_comment('tOboGo_MetencephalonDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","metencephalon","over","time",",","from","its","formation","to","the","mature","structure","."),4042463). assertion_content_comment('tOboGo_Metestrus',s("The","estrous","cycle","phase","in","which","there","is","subsiding","follicular","function","."),4160029). assertion_content_comment('tOboGo_MethaneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","methane",",","a","colorless",",","odorless",",","flammable","gas","with","the","formula","CH4",".","It","is","the","simplest","of","the","alkanes","."),4351614). assertion_content_comment('tOboGo_MethaneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methane",",","a","colorless",",","odorless",",","flammable","gas","with","the","formula","CH4",".","It","is","the","simplest","of","the","alkanes","."),4239872). assertion_content_comment('tOboGo_MethaneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","methane","+","NAD","(","P",")","H","+","H","+","+","O2","=","methanol","+","NAD","(","P",")","+","+","H2O","."),4296967). assertion_content_comment('tOboGo_MethaneMonooxygenaseComplex',s("A","protein","complex","that","possesses","methane","monooxygenase","activity",";","dimeric","and","trimeric","complexes","have","been","characterized","."),4297234). assertion_content_comment('tOboGo_MethanesulfonateMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","methanesulfonate","+","NADH","+","H","+","+","O2","=","formaldehyde","+","NAD","+","+","sulfite","+","H2O","."),4276296). assertion_content_comment('tOboGo_MethanesulfonicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methanesulfonic","acid",",","a","strong","acid","produced","by","the","oxidation","of","dimethyl","sulfide","."),4272142). assertion_content_comment('tOboGo_MethanethiolOxidaseActivity',s("Catalysis","of","the","reaction",":","methanethiol","+","O2","+","H2O","=","formaldehyde","+","hydrogen","sulfide","+","hydrogen","peroxide","."),4278959). assertion_content_comment('tOboGo_MethanogenesisFromAcetate',s("The","formation","of","methane",",","a","colorless",",","odorless",",","flammable","gas","with","the","formula","CH4",",","from","other","components",",","including","acetate","."),4239910). assertion_content_comment('tOboGo_MethanogenesisFromCarbonDioxide',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","methane",",","a","colorless",",","odorless",",","flammable","gas","with","the","formula","CH4",",","from","other","compounds",",","including","carbon","dioxide","(","CO2",")"),4239922). assertion_content_comment('tOboGo_MethanogenesisFromMethanol',s("The","formation","of","methane",",","a","colorless",",","odorless",",","flammable","gas","with","the","formula","CH4",",","from","other","components",",","including","methanol","."),4239934). assertion_content_comment('tOboGo_Methanogenesis',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","methane",",","a","colorless",",","odorless",",","flammable","gas","with","the","formula","CH4",".","It","is","the","simplest","of","the","alkanes","."),4239906). assertion_content_comment('tOboGo_MethanolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","methanol",",","CH3-OH",",","a","colorless",",","flammable",",","mobile",",","poisonous","liquid",",","widely","used","as","a","solvent","."),4351419). assertion_content_comment('tOboGo_MethanolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","methanol",",","CH3-OH",",","a","colorless",",","flammable",",","mobile",",","poisonous","liquid",",","widely","used","as","a","solvent","."),4351571). assertion_content_comment('tOboGo_MethanolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","methanol","+","NAD","(","+",")","=","formaldehyde","+","H","(","+",")","+","NADH","."),4270694). assertion_content_comment('tOboGo_MethanolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methanol",",","CH3-OH",",","a","colorless",",","flammable",",","mobile",",","poisonous","liquid",",","widely","used","as","a","solvent","."),4294590). assertion_content_comment('tOboGo_MethanolOxidaseActivity',s("Catalysis","of","the","reaction",":","O2","+","methanol","=","H2O2","+","formaldehyde","."),4358829). assertion_content_comment('tOboGo_MethanolOxidation',s("The","chemical","reactions","and","pathways","resulting","in","the","conversion","of","methanol","to","methyl-Coenzyme","M","."),4294709). assertion_content_comment('tOboGo_MethenyltetrahydrofolateCyclohydrolaseActivity',s("Catalysis","of","the","reaction",":","5",",","10-methenyltetrahydrofolate","+","H2O","=","10-formyltetrahydrofolate","."),4205456). assertion_content_comment('tOboGo_MethenyltetrahydromethanopterinCyclohydrolaseActivity',s("Catalysis","of","the","reaction",":","5",",","10-methenyl-5",",","6",",","7",",","8-tetrahydromethanopterin","+","H","(","2",")","O","=","N","(","5",")","-formyl-5",",","6",",","7",",","8-tetrahydromethanopterin","+","H","(","+",")"),4274761). assertion_content_comment('tOboGo_MethionineAdenosyltransferaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","L-methionine","+","H2O","=","phosphate","+","diphosphate","+","S-adenosyl-L-methionine","."),4205513). assertion_content_comment('tOboGo_MethionineAdenosyltransferaseComplex',s("A","multimeric","enzyme","complex","composed","of","variable","numbers","of","catalytic","alpha","subunits",",","and","noncatalytic","beta","subunits",".","The","beta","subunits","are","believed","to","have","a","regulatory","function",".","The","enzyme","complex","catalyzes","the","synthesis","of","S-adenosylmethionine","(","AdoMet",")",",","which","is","the","major","methyl","group","donor",",","participating","in","the","methylation","of","proteins",",","DNA",",","RNA",",","phospholipids",",","and","other","small","molecules","."),4384762). assertion_content_comment('tOboGo_MethionineAdenosyltransferaseRegulatorActivity',s("Modulates","the","activity","of","methionine","adenosyltransferase","."),4384796). assertion_content_comment('tOboGo_MethionineAndThreonineMetabolicProcess',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4272267). assertion_content_comment('tOboGo_MethionineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","methionine","(","2-amino-4-","(","methylthio",")","butanoic","acid",")",",","a","sulfur-containing",",","essential","amino","acid","found","in","peptide","linkage","in","proteins","."),4045982). assertion_content_comment('tOboGo_MethionineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","methionine","(","2-amino-4-","(","methylthio",")","butanoic","acid",")",",","a","sulfur-containing",",","essential","amino","acid","found","in","peptide","linkage","in","proteins","."),4241691). assertion_content_comment('tOboGo_MethionineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","L-methionine","+","H","(","+",")","=","3-methylthiopropanamine","+","CO","(","2",")"),4270718). assertion_content_comment('tOboGo_MethionineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methionine","(","2-amino-4-","(","methylthio",")","butanoic","acid",")",",","a","sulfur-containing",",","essential","amino","acid","found","in","peptide","linkage","in","proteins","."),4045976). assertion_content_comment('tOboGo_MethionineRacemaseActivity',s("Catalysis","of","the","reaction",":","L-methionine","=","D-methionine","."),4285118). assertion_content_comment('tOboGo_MethionineSynthaseActivity',s("Catalysis","of","the","reaction",":","(","6S",")","-5-methyl-5",",","6",",","7",",","8-tetrahydrofolate","+","L-homocysteine","=","(","6S",")","-5",",","6",",","7",",","8-tetrahydrofolate","+","L-methionine","."),4251947). assertion_content_comment('tOboGo_MethionineSynthaseReductaseActivity',s("Catalysis","of","the","reaction",":","[","methionine","synthase","]","-cob","(","II",")","alamin","+","NADPH","+","H","+","+","S-adenosyl","methionine","=","[","methionine","synthase","]","-methylcob","(","I",")","alamin","+","S-adenosylhomocysteine","+","NADP","+"),4307719). assertion_content_comment('tOboGo_MethionineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","methionine","from","one","side","of","a","membrane","to","the","other","."),4295661). assertion_content_comment('tOboGo_MethionineTransport',s("The","directed","movement","of","methionine",",","2-amino-4-","(","methylthio",")","butanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293761). assertion_content_comment('tOboGo_MethionylAminopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","N-terminal","amino","acids",",","preferentially","methionine",",","from","peptides","and","arylamides","."),4210009). assertion_content_comment('tOboGo_MethionylGlutamylTRNASynthetaseComplex',s("A","complex","consisting","of","methionyl-","and","glutamyl-tRNA","synthetases",".","The","tRNA","synthetases","present","in","the","complex","bind","to","their","cognate","tRNAs","more","efficiently","than","they","do","as","monomers","."),4267656). assertion_content_comment('tOboGo_MethotrexateBinding',s("Interacting","selectively","and","non-covalently","with","methotrexate",",","an","antineoplastic","antimetabolite","with","immunosuppressant","properties",".","It","is","an","inhibitor","of","tetrahydrofolate","reductase","and","prevents","the","formation","of","tetrahydrofolate",",","necessary","for","synthesis","of","thymidylate",",","an","essential","component","of","DNA","."),4282156). assertion_content_comment('tOboGo_MethotrexateTransporterActivity',s("Enables","the","directed","movement","of","methotrexate",",","4-amino-10-methylformic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Methotrexate","is","a","folic","acid","analogue","and","a","potent","competitive","inhibitor","of","dihydrofolate","reductase","."),4296022). assertion_content_comment('tOboGo_MethotrexateTransport',s("The","directed","movement","of","methotrexate",",","4-amino-10-methylformic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Methotrexate","is","a","folic","acid","analogue","and","a","potent","competitive","inhibitor","of","dihydrofolate","reductase","."),4183862). assertion_content_comment('tOboGo_MethylamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methylamine","(","CH3NH2",")",",","a","flammable",",","explosive","gas",",","used","in","tanning","and","in","organic","synthesis","and","produced","naturally","in","some","decaying","fish",",","certain","plants",",","and","crude","methanol","."),4309923). assertion_content_comment('tOboGo_MethylammoniumChannelActivity',s("Catalysis","of","facilitated","diffusion","of","methylammonium","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel","without","evidence","for","a","carrier-mediated","mechanism",".","Methylammonium","is","CH3NH2","."),4295346). assertion_content_comment('tOboGo_MethylammoniumTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","methylammonium",",","CH3NH2",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4295344). assertion_content_comment('tOboGo_MethylammoniumTransmembraneTransport',s("The","directed","movement","of","methylammonium","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4156601). assertion_content_comment('tOboGo_MethylammoniumTransport',s("The","directed","movement","of","methylammonium","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4156598). assertion_content_comment('tOboGo_MethylarsonateReductaseActivity',s("Catalysis","of","the","reaction",":","2","glutathione","+","H","(","+",")","+","methylarsonate","=","glutathione","disulfide","+","H","(","2",")","O","+","methylarsonous","acid","."),4278050). assertion_content_comment('tOboGo_MethylarsoniteMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","methylarsonite","=","S-adenosyl-L-homocysteine","+","dimethylarsinate","."),4309101). assertion_content_comment('tOboGo_MethylaspartateMutaseActivity',s("Catalysis","of","the","reaction",":","threo-3-methyl-L-aspartate","=","L-glutamate","."),4270650). assertion_content_comment('tOboGo_MethylatedHistoneResidueBinding',s("Interacting","selectively","and","non-covalently","with","a","methylated","residue","on","a","histone","protein",".","Histones","are","any","of","a","group","of","water-soluble","proteins","found","in","association","with","the","DNA","of","plant","and","animal","chromosomes","."),4381800). assertion_content_comment('tOboGo_Methylation',s("The","process","in","which","a","methyl","group","is","covalently","attached","to","a","molecule","."),3975510). assertion_content_comment('tOboGo_MethylcytosineDioxygenaseActivity',s("Catalysis","of","the","reaction",":","methylcytosine","+","2-oxoglutarate","+","O2","=","5-hydroxymethylcytosine","+","succinate","+","CO2","."),4175183). assertion_content_comment('tOboGo_MethylenediureaDeaminaseActivity',s("Catalysis","of","the","reaction",":","2","H2O","+","methylenediurea","=","CO2","+","2","NH3","+","N-hydroxymethylurea","."),4369906). assertion_content_comment('tOboGo_MethylenetetrahydrofolateDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","5",",","10-methylenetetrahydrofolate","+","NAD","(","+",")","=","5",",","10-methenyltetrahydrofolate","+","NADH","."),4206069). assertion_content_comment('tOboGo_MethylenetetrahydrofolateDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","5",",","10-methylenetetrahydrofolate","+","NADP","(","+",")","=","5",",","10-methenyltetrahydrofolate","+","NADPH","."),4206058). assertion_content_comment('tOboGo_MethylenetetrahydrofolateReductaseFerredoxinActivity',s("Catalysis","of","the","reaction",":","5-methyltetrahydrofolate","+","oxidized","ferredoxin","=","5",",","10-methylenetetrahydrofolate","+","reduced","ferredoxin","."),4228348). assertion_content_comment('tOboGo_MethylenetetrahydrofolateReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","5-methyltetrahydrofolate","+","NAD","(","P",")","+","=","5",",","10-methylenetetrahydrofolate","+","NAD","(","P",")","H","+","H","+"),4206018). assertion_content_comment('tOboGo_MethylenetetrahydromethanopterinDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","5",",","10-methylenetetrahydromethanopterin","+","coenzyme","F420","+","2","H","(","+",")","=","5",",","10-methenyl-5",",","6",",","7",",","8-tetrahydromethanopterin","+","reduced","coenzyme","F","(","420",")"),4312013). assertion_content_comment('tOboGo_MethylEthylKetoneBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","methyl","ethyl","ketone",",","a","clear",",","colorless","liquid","with","a","fragrant",",","mint-like","odor",".","It","is","used","as","a","solvent","and","in","making","plastics",",","textiles","and","paints","."),4354322). assertion_content_comment('tOboGo_MethylEthylKetoneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","methyl","ethyl","ketone",",","a","clear",",","colorless","liquid","with","a","fragrant",",","mint-like","odor","."),4354308). assertion_content_comment('tOboGo_MethylEthylKetoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methyl","ethyl","ketone",",","a","clear",",","colorless","liquid","with","a","fragrant",",","mint-like","odor",".","It","is","used","as","a","solvent","and","in","making","plastics",",","textiles","and","paints","."),4272250). assertion_content_comment('tOboGo_MethylFluorideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methyl","fluoride",",","fluorine-substituted","methane",",","a","gaseous","halogenated","hydrocarbon","that","has","been","investigated","as","an","inhibitor","of","methanotrophy","and","nitrification","in","soils","."),4272238). assertion_content_comment('tOboGo_MethylgalactosideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","methylgalactoside","from","one","side","of","the","membrane","to","the","other",".","Methylgalactoside","is","a","compound","in","which","the","H","of","the","OH","group","on","carbon-1","of","galactose","is","replaced","by","a","methyl","group","."),4289651). assertion_content_comment('tOboGo_MethylgalactosideTransport',s("The","directed","movement","of","methylgalactoside","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Methylgalactoside","is","a","compound","in","which","the","H","of","the","OH","group","on","carbon-1","of","galactose","is","replaced","by","a","methyl","group","."),4291151). assertion_content_comment('tOboGo_MethylgallateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","methylgallate",",","trihydroxymethylbenzoate",",","the","anion","of","methylgallic","acid","."),4353340). assertion_content_comment('tOboGo_MethylgallateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","methylgallate",",","trihydroxymethylbenzoate",",","the","anion","of","methylgallic","acid","."),4353308). assertion_content_comment('tOboGo_MethylgallateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methylgallate",",","trihydroxymethylbenzoate",",","the","anion","of","methylgallic","acid","."),4241200). assertion_content_comment('tOboGo_MethylglutamateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","N-methyl-L-glutamate","+","A","+","H","(","2",")","O","=","L-glutamate","+","AH","(","2",")","+","formaldehyde","."),4270669). assertion_content_comment('tOboGo_MethylglyoxalBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","methylglyoxal",",","CH3-CO-CHO",",","the","aldehyde","of","pyruvic","acid","."),4238536). assertion_content_comment('tOboGo_MethylglyoxalCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","methylglyoxal",",","CH3-CO-CHO",",","the","aldehyde","of","pyruvic","acid","."),4238496). assertion_content_comment('tOboGo_MethylglyoxalMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methylglyoxal",",","CH3-CO-CHO",",","the","aldehyde","of","pyruvic","acid","."),4238476). assertion_content_comment('tOboGo_MethylglyoxalSynthaseActivity',s("Catalysis","of","the","reaction",":","glycerone","phosphate","=","methylglyoxal","+","phosphate","."),4248847). assertion_content_comment('tOboGo_MethylguanidinaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","methylguanidine","=","methylammonium","+","urea","."),4270638). assertion_content_comment('tOboGo_MethylisocitrateLyaseActivity',s("Catalysis","of","the","reaction",":","(","2S",",","3R",")","-3-hydroxybutane-1",",","2",",","3-tricarboxylate","=","pyruvate","+","succinate","."),4351267). assertion_content_comment('tOboGo_MethylJasmonateEsteraseActivity',s("Catalysis","of","the","reaction",":","a","methyl","jasmonate","+","H2O","=","a","jasmonic","acid","+","methanol","."),4181912). assertion_content_comment('tOboGo_MethylmercuryBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","methylmercury","(","MeHg","+",")",",","a","highly","toxic","organometal","."),4313548). assertion_content_comment('tOboGo_MethylmercuryCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","methylmercury","(","MeHg","+",")",",","a","highly","toxic","organometal","."),4313580). assertion_content_comment('tOboGo_MethylmercuryMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","methylmercury","(","MeHg","+",")",",","a","highly","toxic","organometal","which","can","accumulate","in","tissues",",","particularly","in","fish","species","."),4313529). assertion_content_comment('tOboGo_MethylnaphthaleneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","methylnaphthalene",",","an","organic","compound",",","C10H7CH3",",","obtained","from","coal","tar","."),4325150). assertion_content_comment('tOboGo_Methylosome',s("A","large","(","20","S",")","protein","complex","that","possesses","protein","arginine","methyltransferase","activity","and","modifies","specific","arginines","to","dimethylarginines","in","the","arginine-","and","glycine-rich","domains","of","several","spliceosomal","Sm","proteins",",","thereby","targeting","these","proteins","to","the","survival","of","motor","neurons","(","SMN",")","complex","for","assembly","into","small","nuclear","ribonucleoprotein","(","snRNP",")","core","particles",".","Proteins","found","in","the","methylosome","include","the","methyltransferase","JBP1","(","PRMT5",")",",","pICln","(","CLNS1A",")",",","MEP50","(","WDR77",")",",","and","unmethylated","forms","of","SM","proteins","that","have","RG","domains","."),4349304). assertion_content_comment('tOboGo_MethylphosphothioglyceratePhosphataseActivity',s("Catalysis","of","the","reaction",":","S-methyl-3-phospho-1-thio-D-glycerate","+","H","(","2",")","O","=","S-methyl-1-thio-D-glycerate","+","phosphate","."),4368623). assertion_content_comment('tOboGo_MethylputrescineOxidaseActivity',s("Catalysis","of","the","reaction",":","N-methylputrescine","+","H2O","+","O2","=","N-methylaminobutanal","+","NH3","+","hydrogen","peroxide","+","H","+"),4192207). assertion_content_comment('tOboGo_MethylSalicylateEsteraseActivity',s("Catalysis","of","the","reaction",":","methyl","salicylate","+","H2O","=","salicylic","acid","+","methanol","+","H","+"),4182232). assertion_content_comment('tOboGo_MethylsilanetriolHydroxylaseActivity',s("Catalysis","of","the","reaction",":","methylsilanetriol","+","O2","+","2","H","+","+","2","e-","=","H2O","+","hydroxymethylsilanetriol","."),4275637). assertion_content_comment('tOboGo_MethylthioadenosineNucleosidaseActivity',s("Catalysis","of","the","reaction",":","methylthioadenosine","+","H2O","=","adenine","+","5-methylthio-D-ribose","."),4248832). assertion_content_comment('tOboGo_MethylthiotransferaseActivity',s("Catalysis","of","the","addition","of","a","methylthioether","group","(","-SCH3",")","to","a","nucleic","acid","or","protein","acceptor","."),4379291). assertion_content_comment('tOboGo_MethyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","an","acceptor","molecule","."),4164116). assertion_content_comment('tOboGo_MethyltransferaseComplex',s("A","protein","complex","that","possesses","methyltransferase","activity","."),4162323). assertion_content_comment('tOboGo_MetulaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","metulae","over","time",",","from","its","formation","to","the","mature","structure",".","Metulae","are","elongated","mononucleate","cells","that","bud","from","the","surface","of","the","conidiophore","tip","."),4132548). assertion_content_comment('tOboGo_MevaldateReductaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-mevalonate","+","acceptor","=","mevaldate","+","reduced","acceptor","."),4205913). assertion_content_comment('tOboGo_MevaldateReductaseNADActivity',s("Catalysis","of","the","reaction",":","(","R",")","-mevalonate","+","NAD","(","+",")","=","H","(","+",")","+","mevaldate","+","NADH","."),4245235). assertion_content_comment('tOboGo_MevaldateReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","(","R",")","-mevalonate","+","NADP","(","+",")","=","H","(","+",")","+","mevaldate","+","NADPH","."),4245244). assertion_content_comment('tOboGo_MevalonateKinaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-mevalonate","+","ATP","=","(","R",")","-5-phosphomevalonate","+","ADP","+","2","H","(","+",")"),4205940). assertion_content_comment('tOboGo_MevalonateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","mevalonate","from","one","side","of","the","membrane","to","the","other",".","Mevalonate","is","the","anion","of","mevalonic","acid",";","its","(","R",")","-enantiomer","is","a","strategic","intermediate","derived","from","hydroxymethylglutaryl-CoA","in","the","biosynthesis","of","polyprenyl","compounds","."),4296072). assertion_content_comment('tOboGo_MevalonateTransport',s("The","directed","movement","of","mevalonate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290825). assertion_content_comment('tOboGo_MG1TransitionOfMitoticCellCycle',s("Progression","from","M","phase","to","G1","phase","of","the","mitotic","cell","cycle","."),3973119). assertion_content_comment('tOboGo_MH1DomainBinding',s("Interacting","selectively","and","non-covalently","with","the","MH1","(","MAD","homology","1",")","domain","of","a","protein",".","The","MH1","domain","is","found","at","the","amino","terminus","of","MAD","related","proteins","such","as","Smads","and","can","mediate","DNA","binding","in","some","proteins",".","Smads","also","use","the","MH1","domain","to","interact","with","some","transcription","factors","."),4377022). assertion_content_comment('tOboGo_MH2DomainBinding',s("Interacting","selectively","and","non-covalently","with","the","MH2","(","MAD","homology","2",")","domain","of","a","protein",".","The","MH2","domain","is","found","at","the","carboxy","terminus","of","MAD","related","proteins","such","as","Smads",".","The","MH2","domain","mediates","interaction","with","a","wide","variety","of","proteins","and","provides","specificity","and","selectivity","to","Smad","function","and","also","is","critical","for","mediating","interactions","in","Smad","oligomers","."),4377044). assertion_content_comment('tOboGo_MHCClassIBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","major","histocompatibility","protein","class","I","."),4085812). assertion_content_comment('tOboGo_MHCClassIbProteinBinding',s("Interacting","selectively","with","major","histocompatibility","complex","class","Ib","molecules","."),4052588). assertion_content_comment('tOboGo_MHCClassIbProteinBindingViaAntigenBindingGroove',s("Interacting","selectively","with","major","histocompatibility","complex","class","Ib","molecules","via","the","antigen","binding","groove","."),4052591). assertion_content_comment('tOboGo_MHCClassIbProteinBindingViaLateralSurface',s("Interacting","selectively","with","major","histocompatibility","complex","class","Ib","molecules","via","the","lateral","surface","."),4347181). assertion_content_comment('tOboGo_MHCClassIbProteinComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","MHC","class","Ib","protein","complex",".","Class","Ib","here","refers","to","non-classical","class","I","molecules","."),3993919). assertion_content_comment('tOboGo_MHCClassIbProteinComplexBinding',s("Interacting","selectively","with","the","class","Ib","major","histocompatibility","complex","."),4052527). assertion_content_comment('tOboGo_MHCClassIbProteinComplex',s("A","transmembrane","protein","complex","composed","of","a","MHC","class","Ib","alpha","chain","and",",","in","most","cases",",","an","invariant","beta2-microglobin","chain",",","and","with","or","without","a","bound","peptide","or","lipid","antigen",".","Class","Ib","here","refers","to","non-classical","class","I","molecules",",","such","as","those","of","the","CD1","or","HLA-E","gene","families","."),4333626). assertion_content_comment('tOboGo_MHCClassIbReceptorActivity',s("Combining","with","an","MHC","class","Ib","protein","complex","to","initiate","a","change","in","cellular","activity",".","Class","Ib","here","refers","to","non-classical","class","I","molecules",",","such","as","those","of","the","CD1","or","HLA-E","gene","families","."),4200125). assertion_content_comment('tOboGo_MHCClassIIBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","major","histocompatibility","protein","class","II","."),4085843). assertion_content_comment('tOboGo_MHCClassIIProteinBinding',s("Interacting","selectively","and","non-covalently","with","major","histocompatibility","complex","class","II","molecules",";","a","set","of","molecules","displayed","on","cell","surfaces","that","are","responsible","for","lymphocyte","recognition","and","antigen","presentation","."),4077789). assertion_content_comment('tOboGo_MHCClassIIProteinBindingViaAntigenBindingGroove',s("Interacting","selectively","and","non-covalently","with","the","antigen","binding","groove","of","major","histocompatibility","complex","class","II","molecules","."),4077794). assertion_content_comment('tOboGo_MHCClassIIProteinBindingViaLateralSurface',s("Interacting","selectively","and","non-covalently","with","the","lateral","surface","of","major","histocompatibility","complex","class","II","molecules","."),4316587). assertion_content_comment('tOboGo_MHCClassIIProteinComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","MHC","class","II","protein","complex","."),3996100). assertion_content_comment('tOboGo_MHCClassIIProteinComplexBinding',s("Interacting","selectively","with","the","class","II","major","histocompatibility","complex","."),4077772). assertion_content_comment('tOboGo_MHCClassIIProteinComplex',s("A","transmembrane","protein","complex","composed","of","an","MHC","class","II","alpha","and","MHC","class","II","beta","chain",",","and","with","or","without","a","bound","peptide","or","polysaccharide","antigen","."),4187971). assertion_content_comment('tOboGo_MHCClassIIReceptorActivity',s("Combining","with","an","MHC","class","II","protein","complex","to","initiate","a","change","in","cellular","activity","."),4200139). assertion_content_comment('tOboGo_MHCClassIPeptideLoadingComplex',s("A","large",",","multisubunit","complex","which","consists","of","the","MHC","class","I-beta","2","microglobulin","dimer",",","the","transporter","associated","with","antigen","presentation","(","TAP",")",",","tapasin","(","an","MHC-encoded","membrane","protein",")",",","the","chaperone","calreticulin","and","the","thiol","oxidoreductase","ERp57",".","Functions","in","the","assembly","of","peptides","with","newly","synthesized","MHC","class","I","molecules","."),4077425). assertion_content_comment('tOboGo_MHCClassIProteinBinding',s("Interacting","selectively","and","non-covalently","with","major","histocompatibility","complex","class","I","molecules",";","a","set","of","molecules","displayed","on","cell","surfaces","that","are","responsible","for","lymphocyte","recognition","and","antigen","presentation","."),4052617). assertion_content_comment('tOboGo_MHCClassIProteinBindingViaAntigenBindingGroove',s("Interacting","selectively","with","major","histocompatibility","complex","class","I","molecules","via","the","antigen","binding","groove","."),4052625). assertion_content_comment('tOboGo_MHCClassIProteinBindingViaLateralSurface',s("Interacting","selectively","with","major","histocompatibility","complex","class","I","molecules","via","the","lateral","surface","."),4347034). assertion_content_comment('tOboGo_MHCClassIProteinComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","MHC","class","I","protein","complex",".","Class","I","here","refers","to","classical","class","I","molecules","."),3996069). assertion_content_comment('tOboGo_MHCClassIProteinComplexBinding',s("Interacting","selectively","with","the","class","I","major","histocompatibility","complex","."),4052600). assertion_content_comment('tOboGo_MHCClassIProteinComplex',s("A","transmembrane","protein","complex","composed","of","a","MHC","class","I","alpha","chain","and","an","invariant","beta2-microglobin","chain",",","and","with","or","without","a","bound","peptide","antigen",".","Class","I","here","refers","to","classical","class","I","molecules","."),4187992). assertion_content_comment('tOboGo_MHCClassIReceptorActivity',s("Combining","with","an","MHC","class","I","protein","complex","to","initiate","a","change","in","cellular","activity",".","Class","I","here","refers","to","classical","class","I","molecules","."),4310926). assertion_content_comment('tOboGo_MHCProteinBinding',s("Interacting","selectively","and","non-covalently","with","major","histocompatibility","complex","molecules",";","a","set","of","molecules","displayed","on","cell","surfaces","that","are","responsible","for","lymphocyte","recognition","and","antigen","presentation","."),4052584). assertion_content_comment('tOboGo_MHCProteinComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","MHC","protein","complex","."),3993917). assertion_content_comment('tOboGo_MHCProteinComplexBinding',s("Interacting","selectively","with","the","major","histocompatibility","complex","."),4052525). assertion_content_comment('tOboGo_MHCProteinComplex',s("A","transmembrane","protein","complex","composed","of","an","MHC","alpha","chain","and",",","in","most","cases",",","either","an","MHC","class","II","beta","chain","or","an","invariant","beta2-microglobin","chain",",","and","with","or","without","a","bound","peptide",",","lipid",",","or","polysaccharide","antigen","."),4187969). assertion_content_comment('tOboGo_Microautophagy',s("The","transfer","of","cytosolic","components","into","the","lysosomal","compartment","by","direct","invagination","of","the","lysosomal","membrane","without","prior","sequestration","into","an","autophagosome",".","The","engulfing","membranes","fuse",",","resulting","in","the","lysosomal","delivery","of","the","cargo","wrapped","in","a","single","membrane","derived","from","the","invaginated","lysosomal","membrane",".","In","S",".","cerevisiae",",","the","vacuole","is","the","lysosomal","compartment","."),4129830). assertion_content_comment('tOboGo_MicrobialCollagenaseActivity',s("OBSOLETE",".","Catalysis","of","the","digestion","of","native","collagen","in","the","triple","helical","region","at","Xaa-Gly","bonds","."),4286856). assertion_content_comment('tOboGo_MicrobodyLumen',s("The","volume","enclosed","by","the","membranes","of","a","microbody","."),4074713). assertion_content_comment('tOboGo_MicrobodyMembrane',s("The","lipid","bilayer","surrounding","a","microbody","."),4007273). assertion_content_comment('tOboGo_MicrobodyPart',s("Any","constituent","part","of","a","microbody",",","a","cytoplasmic","organelle",",","spherical","or","oval","in","shape",",","that","is","bounded","by","a","single","membrane","and","contains","oxidative","enzymes",",","especially","those","utilizing","hydrogen","peroxide","(","H2O2",")"),4007292). assertion_content_comment('tOboGo_Microbody',s("Cytoplasmic","organelles",",","spherical","or","oval","in","shape",",","that","are","bounded","by","a","single","membrane","and","contain","oxidative","enzymes",",","especially","those","utilizing","hydrogen","peroxide","(","H2O2",")"),4007271). assertion_content_comment('tOboGo_MicrocinB17Transport',s("The","directed","movement","of","microcin","B17",",","a","bactericidal","peptide","(","antibiotic",")","produced","by","some","enteric","bacteria",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4314966). assertion_content_comment('tOboGo_MicrocinTransport',s("The","directed","movement","of","microcin",",","a","class","of","glycine-rich",",","bactericidal","peptides","(","antibiotics",")","produced","by","some","enteric","bacteria",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4314964). assertion_content_comment('tOboGo_MicrocinUptakeTransporterActivity',s("Catalysis","of","the","transfer","of","a","microcin","from","the","outside","of","a","cell","to","the","inside","of","the","cell","across","a","membrane","."),4290563). assertion_content_comment('tOboGo_MicrofibrilBinding',s("Interacting","selectively","and","non-covalently","with","a","microfibril",",","any","small","fibril","occurring","in","biological","material","."),4267001). assertion_content_comment('tOboGo_Microfibril',s("Extracellular","matrix","components","occurring","independently","or","along","with","elastin",".","Thought","to","have","force-bearing","functions","in","tendon",".","In","addition","to","fibrillins",",","microfibrils","may","contain","other","associated","proteins","."),4023073). assertion_content_comment('tOboGo_MicrofilamentMotorActivity',s("Catalysis","of","movement","along","a","microfilament",",","coupled","to","the","hydrolysis","of","a","nucleoside","triphosphate","(","usually","ATP",")"),4159565). assertion_content_comment('tOboGo_Microgametogenesis',s("The","process","whose","specific","outcome","is","the","progression","of","the","pollen","grain","over","time",",","from","its","formation","as","the","microspore","to","the","mature","structure","."),4053684). assertion_content_comment('tOboGo_MicrogliaDevelopment',s("The","process","aimed","at","the","progression","of","a","microglial","cell","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4036428). assertion_content_comment('tOboGo_MicrogliaDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","microglial","cell",".","Microglia","are","glial","cells","that","act","as","the","immune","cells","of","the","central","nervous","system",".","They","form","part","of","the","supporting","structure","of","this","system","."),4036212). assertion_content_comment('tOboGo_MicroglialCellActivationInvolvedInImmuneResponse',s("The","change","in","morphology","and","behavior","of","a","microglial","cell","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4378468). assertion_content_comment('tOboGo_MicroglialCellActivation',s("The","change","in","morphology","and","behavior","of","a","microglial","cell","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),4378454). assertion_content_comment('tOboGo_Micromitophagy',s("Degradation","of","a","mitochondrion","by","microautophagy","."),4362568). assertion_content_comment('tOboGo_MicronemeLumen',s("The","volume","enclosed","by","the","microneme","membrane","."),4074789). assertion_content_comment('tOboGo_MicronemeMembrane',s("The","lipid","bilayer","surrounding","a","microneme","."),4065347). assertion_content_comment('tOboGo_Microneme',s("A","small",",","elongated","secretory","organelle","that","forms","part","of","the","apical","complex",",","located","along","the","main","axis","of","an","apicomplexan","parasite","cell","within","the","extreme","apical","region","and","at","the","periphery","under","the","inner","membrane","complex",".","Of","the","specialized","secretory","compartments","identified","in","apicomplexans",",","micronemes","discharge","their","contents","first",",","during","initial","contact","of","the","parasite","'","s","apical","pole","with","the","host","cell","surface",".","Micronemal","proteins","function","during","parasite","attachment","and","penetration","into","the","target","cell","."),4041742). assertion_content_comment('tOboGo_MicronucleusOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","micronucleus","."),4329238). assertion_content_comment('tOboGo_Micronucleus',s("A","membrane-bounded","organelle","of","ciliated","protozoan","cells","that","contains","a","diploid","copy","of","the","cell","'","s","complete","genome",".","Sections","of","contiguous","sequence","in","the","macronucleus","are","often","interrupted","by","internal","eliminated","sequences","(","IES",")",",","and","may","be","permuted",",","in","micronuclei",".","Genic","transcription","is","not","found","in","micronuclei",".","Some","ciliate","species","may","contain","multiple","micronuclei","per","cell","."),4319408). assertion_content_comment('tOboGo_Micropexophagy',s("Degradation","of","a","peroxisome","by","micropexophagy","."),4362617). assertion_content_comment('tOboGo_MicroprocessorComplex',s("A","protein","complex","that","binds","to","heme","and","to","pri-miRNAs",",","and","is","required","for","the","formation","of","a","pre-microRNA","(","pre-miRNA",")",",","the","initial","step","of","microRNA","(","miRNA",")","biogenesis",".","The","complex","is","composed","of","the","double-stranded-RNA-specific","RNase","Drosha","(","also","called","RNASEN",")","and","the","RNA-binding","protein","DGCR8","(","heme-free","or","heme-bound","forms",")","Within","the","complex",",","DGCR8","function","as","a","molecular","anchor","necessary","for","the","recognition","of","pri-miRNA","at","dsRNA-ssRNA","junction","and","directs","RNASEN/Drosha","to","cleave","the","3","'","and","5","'","strands","of","a","stem-loop","to","release","hairpin-shaped","pre-miRNAs","."),4178581). assertion_content_comment('tOboGo_MicropyleFormation',s("Establishment","of","the","micropyle",",","a","single","cone-shaped","specialization","of","the","chorion","that","allows","sperm","entry","into","the","egg","prior","to","fertilization","."),4099472). assertion_content_comment('tOboGo_Micropyle',s("An","external","encapsulating","structure","part","of","the","chorion",".","A","single","cone-shaped","specialization","that","forms","an","opening","in","the","chorion","that","allows","sperm","entry","into","the","egg","prior","to","fertilization","."),4132332). assertion_content_comment('tOboGo_MicroRNABiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","microRNA",",","a","large","family","of","21-22","nucleotide","non-coding","RNAs","with","presumed","post-transcriptional","regulatory","activity","."),4333917). assertion_content_comment('tOboGo_MicroRNAMetabolicProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","involving","microRNA",",","a","large","family","of","21-22","nucleotide","non-coding","RNAs","with","presumed","post-transcriptional","regulatory","activity","."),4333934). assertion_content_comment('tOboGo_Microsome',s("Any","of","the","small",",","heterogeneous",",","artifactual",",","vesicular","particles",",","50-150","nm","in","diameter",",","that","are","formed","when","some","eukaryotic","cells","are","homogenized","and","that","sediment","on","centrifugation","at","100000","g","."),4219944). assertion_content_comment('tOboGo_MicrospikeAssembly',s("Formation","of","a","microspike",",","a","thin",",","stiff","projection","extended","from","the","surface","of","a","migrating","cell","."),4118954). assertion_content_comment('tOboGo_MicrosporocyteDifferentiation',s("The","process","aimed","at","the","progression","of","a","microsporocyte","cell","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell",".","A","microsporocyte","is","a","diploid","(","2n",")","cell","that","undergoes","meiosis","and","forms","four","haploid","(","1n",")","microspores",";","also","called","microspore","mother","cell","and",",","in","seed","plants",",","pollen","mother","cell","."),4029640). assertion_content_comment('tOboGo_MicrosporocyteNucleus',s("The","nucleus","of","the","microsporocyte",".","The","microsporocyte","is","a","diploid","cell","in","which","meiosis","will","occur",",","resulting","in","four","microspores",".","A","microspore","is","a","spore","that",",","in","vascular","plants",",","gives","rise","to","a","male","gametophyte","."),4332351). assertion_content_comment('tOboGo_Microsporogenesis',s("The","process","in","which","the","microsporocyte","undergoes","meiosis",",","giving","rise","to","four","haploid","microspores","."),4023127). assertion_content_comment('tOboGo_MicrotubuleAnchoringAtCentrosome',s("Any","process","in","which","a","microtubule","is","maintained","in","a","specific","location","in","a","cell","by","attachment","to","a","centrosome","."),4357148). assertion_content_comment('tOboGo_MicrotubuleAnchoringAtMicrotubuleOrganizingCenter',s("Any","process","in","which","a","microtubule","is","maintained","in","a","specific","location","in","a","cell","by","attachment","to","a","microtubule","organizing","center","."),4073515). assertion_content_comment('tOboGo_MicrotubuleAnchoringAtSpindlePoleBody',s("Any","process","in","which","a","microtubule","is","maintained","in","a","specific","location","in","a","cell","by","attachment","to","a","spindle","pole","body",".","Microtubules","attach","to","spindle","pole","bodies","at","the","minus","end","."),4073520). assertion_content_comment('tOboGo_MicrotubuleAnchoring',s("Any","process","in","which","a","microtubule","is","maintained","in","a","specific","location","in","a","cell","."),4060063). assertion_content_comment('tOboGo_MicrotubuleAssociatedComplex',s("Any","multimeric","complex","connected","to","a","microtubule","."),4008364). assertion_content_comment('tOboGo_MicrotubuleBasalBodyDuplication',s("Construction","of","a","new","microtubule","basal","body","."),4330353). assertion_content_comment('tOboGo_MicrotubuleBasalBodyOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","microtubule","basal","body",",","a","short","cylindrical","array","of","microtubules","and","associated","proteins","found","at","the","base","of","a","eukaryotic","cilium","or","flagellum","."),4330350). assertion_content_comment('tOboGo_MicrotubuleBasalBody',s("A","short","cylindrical","array","of","microtubules","and","associated","proteins","found","at","the","base","of","a","eukaryotic","cilium","or","flagellum","that","is","similar","in","structure","to","a","centriole",".","The","basal","body","serves","as","a","nucleation","site","for","axoneme","growth","."),4220654). assertion_content_comment('tOboGo_MicrotubuleBinding',s("Interacting","selectively","and","non-covalently","with","microtubules",",","filaments","composed","of","tubulin","monomers","."),4247367). assertion_content_comment('tOboGo_MicrotubuleBundleFormation',s("A","process","that","results","in","a","parallel","arrangement","of","microtubules","."),4016793). assertion_content_comment('tOboGo_MicrotubuleChromatinInteraction',s("OBSOLETE",".","Physical","interaction","between","microtubules","and","chromatin","via","DNA","binding","proteins","."),4252631). assertion_content_comment('tOboGo_MicrotubuleCytoskeletonOrganizationInvolvedInEstablishmentOfPlanarPolarity',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","microtubules","and","their","associated","proteins","and","contributes","to","the","establishment","of","planar","polarity","."),4149401). assertion_content_comment('tOboGo_MicrotubuleCytoskeletonOrganizationInvolvedInSynapsis',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","microtubules","and","their","associated","proteins","that","contributes","to","chromosomal","pairing","."),4149341). assertion_content_comment('tOboGo_MicrotubuleCytoskeletonOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","microtubules","and","their","associated","proteins","."),3969264). assertion_content_comment('tOboGo_MicrotubuleCytoskeleton',s("The","part","of","the","cytoskeleton","(","the","internal","framework","of","a","cell",")","composed","of","microtubules","and","associated","proteins","."),3973709). assertion_content_comment('tOboGo_MicrotubuleDepolymerizationDuringNuclearCongression',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310093). assertion_content_comment('tOboGo_MicrotubuleDepolymerization',s("The","removal","of","tubulin","heterodimers","from","one","or","both","ends","of","a","microtubule","."),4013216). assertion_content_comment('tOboGo_MicrotubuleMotorActivity',s("Catalysis","of","movement","along","a","microtubule",",","coupled","to","the","hydrolysis","of","a","nucleoside","triphosphate","(","usually","ATP",")"),4193077). assertion_content_comment('tOboGo_MicrotubuleNucleationByMicrotubuleOrganizingCenter',s("The","'","de","novo","'","formation","of","a","microtubule",",","mediated","by","the","microtubule","organizing","center","."),4118165). assertion_content_comment('tOboGo_MicrotubuleNucleationBySpindlePoleBody',s("The","'","de","novo","'","formation","of","a","microtubule",",","mediated","by","the","spindle","pole","body","."),4286785). assertion_content_comment('tOboGo_MicrotubuleNucleation',s("The","'","de","novo","'","formation","of","a","microtubule",",","in","which","tubulin","heterodimers","form","metastable","oligomeric","aggregates",",","some","of","which","go","on","to","support","formation","of","a","complete","microtubule",".","Microtubule","nucleation","usually","occurs","from","a","specific","site","within","a","cell","."),4035596). assertion_content_comment('tOboGo_MicrotubuleOrganizingCenterAttachmentSiteOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","microtubule","organizing","center","attachment","site",".","A","microtubule","organizing","center","attachment","site","is","a","region","of","the","nuclear","envelope","to","which","a","microtubule","organizing","center","(","MTOC",")","attaches","."),4072316). assertion_content_comment('tOboGo_MicrotubuleOrganizingCenterAttachmentSite',s("A","region","of","the","nuclear","envelope","to","which","a","microtubule","organizing","center","(","MTOC",")","attaches",";","protein","complexes","embedded","in","the","nuclear","envelope","mediate","direct","or","indirect","linkages","between","the","microtubule","cytoskeleton","and","the","nuclear","envelope","."),4072330). assertion_content_comment('tOboGo_MicrotubuleOrganizingCenterOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","microtubule","organizing","center",",","a","structure","from","which","microtubules","grow","."),3970526). assertion_content_comment('tOboGo_MicrotubuleOrganizingCenterPart',s("Any","constituent","part","of","a","microtubule","organizing","center",",","a","region","in","a","eukaryotic","cell",",","such","as","a","centrosome","or","basal","body",",","from","which","microtubules","grow","."),3973813). assertion_content_comment('tOboGo_MicrotubuleOrganizingCenter',s("A","cytoplasmic","structure","that","can","catalyze","gamma-tubulin-dependent","microtubule","nucleation","and","that","can","anchor","microtubules","by","interacting","with","their","minus","ends",",","plus","ends","or","sides","."),3973790). assertion_content_comment('tOboGo_MicrotubulePlusEnd',s("The","growing","(","plus",")","end","of","a","microtubule",".","In","vitro",",","microtubules","polymerize","more","quickly","at","the","plus","end","than","at","the","minus","end",".","In","vivo",",","microtubule","growth","occurs","only","at","the","plus","end",",","and","the","plus","end","switches","between","periods","of","growth","and","shortening",",","a","behavior","known","as","dynamic","instability","."),4083279). assertion_content_comment('tOboGo_MicrotubulePolymerizationOrDepolymerization',s("Assembly","or","disassembly","of","microtubules","by","the","addition","or","removal","of","tubulin","heterodimers","from","a","microtubule","."),4013213). assertion_content_comment('tOboGo_MicrotubulePolymerization',s("The","addition","of","tubulin","heterodimers","to","one","or","both","ends","of","a","microtubule","."),4062607). assertion_content_comment('tOboGo_Microtubule',s("Any","of","the","long",",","generally","straight",",","hollow","tubes","of","internal","diameter","12-15","nm","and","external","diameter","24","nm","found","in","a","wide","variety","of","eukaryotic","cells",";","each","consists","(","usually",")","of","13","protofilaments","of","polymeric","tubulin",",","staggered","in","such","a","manner","that","the","tubulin","monomers","are","arranged","in","a","helical","pattern","on","the","microtubular","surface",",","and","with","the","alpha/beta","axes","of","the","tubulin","subunits","parallel","to","the","long","axis","of","the","tubule",";","exist","in","equilibrium","with","pool","of","tubulin","monomers","and","can","be","rapidly","assembled","or","disassembled","in","response","to","physiological","stimuli",";","concerned","with","force","generation",",","e.g",".","in","the","spindle","."),3973738). assertion_content_comment('tOboGo_MicrotubuleSeveringActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4255210). assertion_content_comment('tOboGo_MicrotubuleSevering',s("The","process","in","which","a","microtubule","is","broken","down","into","smaller","segments","."),4255206). assertion_content_comment('tOboGo_MicrotubuleSliding',s("The","movement","of","one","microtubule","along","another","microtubule","."),4279110). assertion_content_comment('tOboGo_MicrovillarActinBundleAssembly',s("Assembly","of","the","parallel","bundle","of","actin","filaments","at","the","core","of","a","microvillus","."),4052753). assertion_content_comment('tOboGo_MicrovillusAssembly',s("Formation","of","a","microvillus",",","a","thin","cylindrical","membrane-covered","projection","on","the","surface","of","a","cell","."),4052728). assertion_content_comment('tOboGo_MicrovillusMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","microvillus","."),4060693). assertion_content_comment('tOboGo_MicrovillusOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","microvillus",",","a","thin","cylindrical","membrane-covered","projection","on","the","surface","of","a","cell","."),4052725). assertion_content_comment('tOboGo_Microvillus',s("Thin","cylindrical","membrane-covered","projections","on","the","surface","of","an","animal","cell","containing","a","core","bundle","of","actin","filaments",".","Present","in","especially","large","numbers","on","the","absorptive","surface","of","intestinal","cells","."),4055654). assertion_content_comment('tOboGo_Micturition',s("The","regulation","of","body","fluids","process","in","which","parasympathetic","nerves","stimulate","the","bladder","wall","muscle","to","contract","and","expel","urine","from","the","body","."),4108601). assertion_content_comment('tOboGo_Midbody',s("A","thin","cytoplasmic","bridge","formed","between","daughter","cells","at","the","end","of","cytokinesis",".","The","midbody","forms","where","the","contractile","ring","constricts",",","and","may","persist","for","some","time","before","finally","breaking","to","complete","cytokinesis","."),4310259). assertion_content_comment('tOboGo_MidbrainDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","midbrain","over","time",",","from","its","formation","to","the","mature","structure",".","The","midbrain","is","the","middle","division","of","the","three","primary","divisions","of","the","developing","chordate","brain","or","the","corresponding","part","of","the","adult","brain","(","in","vertebrates",",","includes","a","ventral","part","containing","the","cerebral","peduncles","and","a","dorsal","tectum","containing","the","corpora","quadrigemina","and","that","surrounds","the","aqueduct","of","Sylvius","connecting","the","third","and","fourth","ventricles",")"),4061343). assertion_content_comment('tOboGo_MidchainAlkaneHydroxylaseActivity',s("Catalysis","of","the","conversion","of","an","alkane","to","a","secondary","alcohol","."),4180903). assertion_content_comment('tOboGo_MiddleEarMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","middle","ear","are","generated","and","organized",".","The","middle","ear","is","the","air-filled","cavity","within","the","skull","of","vertebrates","that","lies","between","the","outer","ear","and","the","inner","ear",".","It","is","linked","to","the","pharynx","(","and","therefore","to","outside","air",")","via","the","Eustachian","tube","and","in","mammals","contains","the","three","ear","ossicles",",","which","transmit","auditory","vibrations","from","the","outer","ear","(","via","the","tympanum",")","to","the","inner","ear","(","via","the","oval","window",")"),4078716). assertion_content_comment('tOboGo_MiddleLamella',s("Layer","of","intercellular","material",",","chiefly","pectic","substances",",","cementing","together","the","primary","walls","of","contiguous","cells","."),4023444). assertion_content_comment('tOboGo_MidgutDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","midgut","over","time",",","from","its","formation","to","the","mature","structure",".","The","midgut","is","the","middle","part","of","the","alimentary","canal","from","the","stomach",",","or","entrance","of","the","bile","duct",",","to",",","or","including",",","the","large","intestine","."),4018273). assertion_content_comment('tOboGo_MigrationInHost',s("The","directional","movement","of","an","organism","from","one","place","to","another","within","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4136574). assertion_content_comment('tOboGo_MigrationInOtherOrganismInvolvedInSymbioticInteraction',s("The","directional","movement","of","an","organism","from","one","place","to","another","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4136570). assertion_content_comment('tOboGo_MigrationOfSymbiontWithinHostByPolymerizationOfHostActin',s("The","directional","movement","of","an","organism",",","usually","a","bacterial","cell",",","from","one","place","to","another","within","its","host","organism",",","by","a","process","involving","continuous","polymerization","of","host","actin","at","one","pole","of","the","symbiont","cell",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4136577). assertion_content_comment('tOboGo_MilkEjection',s("An","automatic","response","to","suckling",",","beginning","with","a","nerve","impulse","from","a","receptor","in","the","mammary","gland","and","ending","with","the","ejection","of","milk","from","the","gland",".","Signaling","never","reaches","a","level","of","consciousness","."),4159652). assertion_content_comment('tOboGo_MilkProtein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4216939). assertion_content_comment('tOboGo_MimosinaseActivity',s("Catalysis","of","the","reaction",":","L-mimosine","+","H","(","2",")","O","=","3-hydroxy-4H-pyrid-4-one","+","L-serine","."),4272027). assertion_content_comment('tOboGo_MineralocorticoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mineralocorticoids",",","hormonal","C21","corticosteroids","synthesized","from","cholesterol","."),4055993). assertion_content_comment('tOboGo_MineralocorticoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mineralocorticoids",",","hormonal","C21","corticosteroids","synthesized","from","cholesterol","."),4229693). assertion_content_comment('tOboGo_MineralocorticoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mineralocorticoids",",","hormonal","C21","corticosteroids","synthesized","from","cholesterol",".","Mineralocorticoids","act","primarily","on","water","and","electrolyte","balance","."),4055990). assertion_content_comment('tOboGo_MineralocorticoidReceptorActivity',s("Combining","with","mineralocorticoid","to","initiate","a","change","in","cell","activity","."),4269077). assertion_content_comment('tOboGo_MineralocorticoidReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","mineralocorticoid","receptor","."),4320513). assertion_content_comment('tOboGo_MineralocorticoidReceptorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","a","mineralocorticoid","binding","to","its","receptor","."),4320440). assertion_content_comment('tOboGo_MinorHistocompatibilityAntigen',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218274). assertion_content_comment('tOboGo_MinorMitochondrialDerivative',s("The","smaller","of","the","two","mitochondrial","derivatives","that","arise","by","the","unfolding","of","the","Nebenkern","during","flagellum","elongation","."),4302732). assertion_content_comment('tOboGo_MiRNABinding',s("Interacting","selectively","and","non-covalently","with","a","microRNA",",","a","21-23","nucleotide","RNA","that","is","processed","from","a","stem-loop","RNA","precursor","(","pre-miRNA",")","that","is","encoded","within","plant","and","animal","genomes","."),4381967). assertion_content_comment('tOboGo_MiRNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","miRNA",",","microRNA",",","a","class","of","single-stranded","RNA","molecules","of","about","21-23","nucleotides","in","length",",","which","regulates","gene","expression","."),4144002). assertion_content_comment('tOboGo_MiRNALoadingOntoRISCInvolvedInGeneSilencingByMiRNA',s("The","transfer","of","a","microRNA","(","miRNA",")","strand","from","a","miRNA",":","miRNA","duplex","onto","the","RNA-initiated","silencing","complex","(","RISC",")"),4071046). assertion_content_comment('tOboGo_MiRNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","miRNA",",","microRNA",",","a","class","of","single-stranded","RNA","molecules","of","about","21-23","nucleotides","in","length",",","which","regulates","gene","expression","."),4143967). assertion_content_comment('tOboGo_MIS12MINDTypeComplex',s("A","multiprotein","kinetochore","subcomplex","that","binds","to","centromeric","chromatin","and","forms","part","of","the","inner","kinetochore",".","It","helps","to","recruit","outer","kinetochore","subunits","that","will","bind","to","microtubules",".","In","humans",",","it","consists","of","MIS12",",","DSN1",",","NSL1","and","PMF1","."),3976737). assertion_content_comment('tOboGo_MisfoldedOrIncompletelySynthesizedProteinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","misfolded","or","attenuated","proteins","."),4170187). assertion_content_comment('tOboGo_MisfoldedProteinBinding',s("Interacting","selectively","and","non-covalently","with","a","misfolded","protein","."),4269463). assertion_content_comment('tOboGo_MisfoldedProteinTransport',s("The","directed","movement","of","misfolded","proteins","in","a","cell",",","including","the","movement","of","proteins","between","specific","compartments","or","structures","within","a","cell","."),4178761). assertion_content_comment('tOboGo_MisfoldedRNABinding',s("Interacting","selectively","and","non-covalently","with","an","RNA","molecule","that","has","assumed","an","incorrect","conformation","."),4355073). assertion_content_comment('tOboGo_MismatchedDNABinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","one","or","more","mismatches","."),4307248). assertion_content_comment('tOboGo_MismatchRepairComplexBinding',s("Interacting","selectively","and","non-covalently","with","a","mismatch","repair","complex","."),4334936). assertion_content_comment('tOboGo_MismatchRepairComplex',s("Any","complex","formed","of","proteins","that","act","in","mismatch","repair","."),4333603). assertion_content_comment('tOboGo_MismatchRepair',s("A","system","for","the","correction","of","errors","in","which","an","incorrect","base",",","which","cannot","form","hydrogen","bonds","with","the","corresponding","base","in","the","parent","strand",",","is","incorporated","into","the","daughter","strand",".","The","mismatch","repair","system","promotes","genomic","fidelity","by","repairing","base-base","mismatches",",","insertion-deletion","loops","and","heterologies","generated","during","DNA","replication","and","recombination","."),3977047). assertion_content_comment('tOboGo_MITETransposition',s("Any","process","involved","in","the","transposition","of","miniature","inverted-repeat","transposable","elements","(","MITEs",")"),4329385). assertion_content_comment('tOboGo_MitochondrialAspartateGlutamateTransport',s("OBSOLETE",".","The","directed","movement","of","aspartate","and","glutamate","into",",","out","of","or","within","a","mitochondrion","."),4228558). assertion_content_comment('tOboGo_MitochondrialATPSynthesisCoupledElectronTransport',s("The","transfer","of","electrons","through","a","series","of","electron","donors","and","acceptors",",","generating","energy","that","is","ultimately","used","for","synthesis","of","ATP",",","as","it","occurs","in","the","mitochondrial","inner","membrane","or","chloroplast","thylakoid","membrane","."),4010651). assertion_content_comment('tOboGo_MitochondrialATPSynthesisCoupledProtonTransport',s("The","transport","of","protons","across","a","mitochondrial","membrane","to","generate","an","electrochemical","gradient","(","proton-motive","force",")","that","powers","ATP","synthesis","."),4317078). assertion_content_comment('tOboGo_MitochondrialCalciumIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","calcium","ions","within","the","cytoplasm","of","a","cell","or","between","mitochondria","and","their","surroundings","."),4283916). assertion_content_comment('tOboGo_MitochondrialCalciumIonTransport',s("The","directed","movement","of","calcium","ions","(","Ca2","+",")","into",",","out","of","or","within","a","mitochondrion","."),4228625). assertion_content_comment('tOboGo_MitochondrialChromosome',s("A","chromosome","found","in","the","mitochondrion","of","a","eukaryotic","cell","."),3973924). assertion_content_comment('tOboGo_MitochondrialChromosomeSegregation',s("The","process","in","which","genetic","material","of","the","mitochondrion",",","in","the","form","of","the","mitochondrial","chromosome",",","is","organized","and","then","physically","separated","and","apportioned","to","two","or","more","sets","."),4149124). assertion_content_comment('tOboGo_MitochondrialCitrateTransport',s("The","directed","movement","of","citrate",",","2-hydroxy-1",",","2",",","3-propanetricarboyxlate",",","into",",","out","of","or","within","a","mitochondrion","."),4228536). assertion_content_comment('tOboGo_MitochondrialCloud',s("A","prominent","mass","in","the","cytoplasm","of","previtellogenic","oocytes",".","The","cloud","contains","both","mitochondria","and","electron-dense","granulofibrillar","material","(","GFM",")","and","is","the","source","of","germinal","granule","material","."),4330724). assertion_content_comment('tOboGo_MitochondrialCrista',s("Any","of","the","inward","folds","of","the","mitochondrial","inner","membrane",".","Their","number",",","extent",",","and","shape","differ","in","mitochondria","from","different","tissues","and","organisms",".","They","appear","to","be","devices","for","increasing","the","surface","area","of","the","mitochondrial","inner","membrane",",","where","the","enzymes","of","electron","transport","and","oxidative","phosphorylation","are","found",".","Their","shape","can","vary","with","the","respiratory","state","of","the","mitochondria","."),4052786). assertion_content_comment('tOboGo_MitochondrialDegradosome',s("The","mitochondrial","degradosome","(","mtEXO",")","is","a","three-protein","complex","which","has","a","3","'","to","5","'","exoribonuclease","activity","and","participates","in","intron-independent","turnover","and","processing","of","mitochondrial","transcripts","."),4300677). assertion_content_comment('tOboGo_MitochondrialDepolarization',s("The","process","in","which","the","membrane","potential","of","the","mitochondria","changes","in","the","depolarizing","direction","from","the","resting","potential",",","from","negative","to","positive","."),4120163). assertion_content_comment('tOboGo_MitochondrialDerivative',s("The","major","and","minor","mitochondrial","derivatives","are","the","mitochondria","of","the","sperm","tail","and","derive","by","the","unfolding","of","the","Nebenkern","during","flagellum","elongation","."),4302714). assertion_content_comment('tOboGo_MitochondrialDNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mitochondrial","DNA","."),4330266). assertion_content_comment('tOboGo_MitochondrialDNAInheritance',s("The","process","in","which","copies","of","the","mitochondrial","genome","are","segregated","or","distributed","into","daughter","mitochondria","upon","mitochondrial","fission","."),4077189). assertion_content_comment('tOboGo_MitochondrialDNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mitochondrial","DNA","."),4056907). assertion_content_comment('tOboGo_MitochondrialDNAPackaging',s("Any","process","in","which","mitochondrial","DNA","and","associated","proteins","are","formed","into","a","compact",",","orderly","structure","."),4154812). assertion_content_comment('tOboGo_MitochondrialDNARepair',s("The","process","of","restoring","mitochondrial","DNA","after","damage","."),4324602). assertion_content_comment('tOboGo_MitochondrialDNAReplication',s("The","process","in","which","new","strands","of","DNA","are","synthesized","in","the","mitochondrion","."),4152057). assertion_content_comment('tOboGo_MitochondrialElectronTransferFlavoproteinComplex',s("A","protein","complex","located","in","the","mitochondrion",".","It","contains","flavin","adenine","dinucleotide","(","FAD",")","that",",","together","with","an","acyl-CoA","dehydrogenase",",","forms","a","system","that","oxidizes","an","acyl-CoA","molecule","and","reduces","ubiquinone","and","other","acceptors","in","the","mitochondrial","electron","transport","system","."),4040936). assertion_content_comment('tOboGo_MitochondrialElectronTransportCytochromeCToOxygen',s("The","transfer","of","electrons","from","cytochrome","c","to","oxygen","that","occurs","during","oxidative","phosphorylation",",","mediated","by","the","multisubunit","enzyme","known","as","complex","IV","."),4010699). assertion_content_comment('tOboGo_MitochondrialElectronTransportNADHToUbiquinone',s("The","transfer","of","electrons","from","NADH","to","ubiquinone","that","occurs","during","oxidative","phosphorylation",",","mediated","by","the","multisubunit","enzyme","known","as","complex","I","."),4010663). assertion_content_comment('tOboGo_MitochondrialElectronTransportSuccinateToUbiquinone',s("The","transfer","of","electrons","from","succinate","to","ubiquinone","that","occurs","during","oxidative","phosphorylation",",","mediated","by","the","multisubunit","enzyme","known","as","complex","II","."),4010675). assertion_content_comment('tOboGo_MitochondrialElectronTransportUbiquinolToCytochromeC',s("The","transfer","of","electrons","from","ubiquinol","to","cytochrome","c","that","occurs","during","oxidative","phosphorylation",",","mediated","by","the","multisubunit","enzyme","known","as","complex","III","."),4010688). assertion_content_comment('tOboGo_MitochondrialEndopeptidaseClpComplex',s("A","Clp","endopeptidase","complex","located","in","the","mitochondrion","."),4021804). assertion_content_comment('tOboGo_MitochondrialEnvelope',s("The","double","lipid","bilayer","enclosing","the","mitochondrion","and","separating","its","contents","from","the","cell","cytoplasm",";","includes","the","intermembrane","space","."),3974086). assertion_content_comment('tOboGo_MitochondrialFission',s("The","division","of","a","mitochondrion","within","a","cell","to","form","two","or","more","separate","mitochondrial","compartments","."),4149100). assertion_content_comment('tOboGo_MitochondrialFragmentationInvolvedInApoptosis',s("The","change","in","the","morphology","of","the","mitochondria","in","an","apoptotic","cell","from","a","highly","branched","network","to","a","fragmented","vesicular","form","."),4326470). assertion_content_comment('tOboGo_MitochondrialFusion',s("Merging","of","two","or","more","mitochondria","within","a","cell","to","form","a","single","compartment","."),4016756). assertion_content_comment('tOboGo_MitochondrialGenomeMaintenance',s("The","maintenance","of","the","structure","and","integrity","of","the","mitochondrial","genome",";","includes","replication","and","segregation","of","the","mitochondrial","chromosome","."),4056897). assertion_content_comment('tOboGo_MitochondrialGlutamateSynthaseComplexNADH',s("A","protein","complex",",","found","in","the","mitochondria",",","that","in","yeast","consists","of","a","large","and","a","small","subunit",".","Possesses","glutamate","synthase","(","NADH",")","activity","."),4093379). assertion_content_comment('tOboGo_MitochondrialHeavyStrandPromoterSenseBinding',s("Interacting","selectively","and","non-covalently","with","the","sense","strand","of","the","heavy","strand","promoter",",","a","promoter","located","on","the","heavy",",","or","guanine-rich",",","strand","of","mitochondrial","DNA","."),4173298). assertion_content_comment('tOboGo_MitochondrialInnerBoundaryMembrane',s("The","portion","of","the","mitochondrial","inner","membrane","that","is","not","invaginated","to","form","cristae",".","The","inner","boundary","membrane","lies","parallel","to","the","outer","membrane","."),4071644). assertion_content_comment('tOboGo_MitochondrialInnerMembranePeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","maturation","of","mitochondrial","precursor","proteins","delivered","to","the","intermembrane","space","."),4210213). assertion_content_comment('tOboGo_MitochondrialInnerMembranePeptidaseComplex',s("Protease","complex","of","the","mitochondrial","inner","membrane",",","consisting","of","at","least","two","subunits",",","involved","in","processing","of","both","nuclear-","and","mitochondrially-encoded","proteins","targeted","to","the","intermembrane","space","."),4078242). assertion_content_comment('tOboGo_MitochondrialInnerMembranePresequenceTranslocaseComplex',s("The","protein","transport","machinery","of","the","mitochondrial","inner","membrane","that","contains","three","essential","Tim","proteins",":","Tim17","and","Tim23","are","thought","to","build","a","preprotein","translocation","channel","while","Tim44","interacts","transiently","with","the","matrix","heat-shock","protein","Hsp70","to","form","an","ATP-driven","import","motor","."),3981788). assertion_content_comment('tOboGo_MitochondrialInnerMembraneProteinInsertionComplex',s("A","multi-subunit","complex","embedded","in","the","mitochondrial","inner","membrane","that","mediates","insertion","of","carrier","proteins","into","the","inner","membrane","."),4078230). assertion_content_comment('tOboGo_MitochondrialInnerMembrane',s("The","inner",",","i.e",".","lumen-facing",",","lipid","bilayer","of","the","mitochondrial","envelope",".","It","is","highly","folded","to","form","cristae","."),3974130). assertion_content_comment('tOboGo_MitochondrialIntermediatePeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","an","N-terminal","octapeptide","as","second","stage","of","processing","of","some","proteins","imported","in","the","mitochondrion","."),4210200). assertion_content_comment('tOboGo_MitochondrialIntermembraneSpaceProteinTransporterComplex',s("Soluble","complex","of","the","mitochondrial","intermembrane","space","composed","of","various","combinations","of","small","Tim","proteins",";","acts","as","a","protein","transporter","to","guide","proteins","to","the","Tim22","complex","for","insertion","into","the","mitochondrial","inner","membrane","."),4078254). assertion_content_comment('tOboGo_MitochondrialIntermembraneSpace',s("The","region","between","the","inner","and","outer","lipid","bilayers","of","the","mitochondrial","envelope","."),4007830). assertion_content_comment('tOboGo_MitochondrialIntracristalSpace',s("The","space","bounded","by","the","mitochondrial","cristae","membranes",",","continuous","with","the","intermembrane","space","."),4288090). assertion_content_comment('tOboGo_MitochondrialIronIonTransport',s("The","directed","movement","of","iron","ions","into",",","out","of","or","within","a","mitochondrion","."),4384942). assertion_content_comment('tOboGo_MitochondrialIsocitrateDehydrogenaseComplexNAD',s("Mitochondrial","complex","that","possesses","isocitrate","dehydrogenase","(","NAD","+",")","activity","."),4221060). assertion_content_comment('tOboGo_MitochondrialLargeRibosomalSubunit',s("The","larger","of","the","two","subunits","of","a","mitochondrial","ribosome",".","Two","sites","on","the","ribosomal","large","subunit","are","involved","in","translation",":","the","aminoacyl","site","(","A","site",")","and","peptidyl","site","(","P","site",")"),4007743). assertion_content_comment('tOboGo_MitochondrialLightStrandPromoterSenseBinding',s("Interacting","selectively","and","non-covalently","with","the","sense","strand","of","the","light","strand","promoter",",","a","promoter","located","on","the","light",",","or","cytosine-rich",",","strand","of","mitochondrial","DNA","."),4173287). assertion_content_comment('tOboGo_MitochondrialLrRNAExportFromMitochondrion',s("The","directed","movement","of","mitochondrial","lrRNA","out","of","a","mitochondrion","."),4236566). assertion_content_comment('tOboGo_MitochondrialMagnesiumIonTransport',s("The","transport","of","magnesium","ions","(","Mg2","+",")","into",",","out","of","or","within","a","mitochondrion",".","Transport","across","the","mitochondrial","membranes","is","mediated","by","a","mitochondrial","inner","membrane","protein","."),4300592). assertion_content_comment('tOboGo_MitochondrialMatrix',s("The","gel-like","material",",","with","considerable","fine","structure",",","that","lies","in","the","matrix","space",",","or","lumen",",","of","a","mitochondrion",".","It","contains","the","enzymes","of","the","tricarboxylic","acid","cycle","and",",","in","some","organisms",",","the","enzymes","concerned","with","fatty","acid","oxidation","."),3973896). assertion_content_comment('tOboGo_MitochondrialMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","mitochondrial","membrane",",","either","of","the","lipid","bilayer","surrounding","a","mitochondrion","."),3986818). assertion_content_comment('tOboGo_MitochondrialMembranePart',s("Any","constituent","part","of","a","mitochondrial","membrane",",","either","of","the","lipid","bilayers","that","surround","the","mitochondrion","and","form","the","mitochondrial","envelope","."),3974090). assertion_content_comment('tOboGo_MitochondrialMembrane',s("Either","of","the","lipid","bilayers","that","surround","the","mitochondrion","and","form","the","mitochondrial","envelope","."),3974088). assertion_content_comment('tOboGo_MitochondrialMRNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mRNA","transcribed","from","the","mitochondrial","genome","and","occurring","in","the","mitochondrion","."),4363325). assertion_content_comment('tOboGo_MitochondrialMRNAEditingComplex',s("An","mRNA","editing","complex","found","in","the","mitochondrion",".","The","best","characterized","example","is","that","of","Trypanosoma","brucei",",","which","catalyzes","the","insertion","and","deletion","of","uridylates","."),4319201). assertion_content_comment('tOboGo_MitochondrialMRNAModification',s("The","covalent","alteration","of","one","or","more","nucleotides","within","a","mitochondrial","mRNA","molecule","to","produce","an","mRNA","molecule","with","a","sequence","that","differs","from","that","coded","genetically","."),4181155). assertion_content_comment('tOboGo_MitochondrialNucleoidOrganizationInvolvedInMitochondrialFission',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","mitochondrial","nucleoid","that","contributes","to","mitochondrial","division","."),4149165). assertion_content_comment('tOboGo_MitochondrialNucleoidOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","mitochondrial","nucleoid",".","The","mitochondrial","nucleoid","is","the","region","of","a","mitochondrion","to","which","the","DNA","is","confined","."),4149162). assertion_content_comment('tOboGo_MitochondrialNucleoid',s("The","region","of","a","mitochondrion","to","which","the","DNA","is","confined","."),3973900). assertion_content_comment('tOboGo_MitochondrialOrnithineTransport',s("The","directed","movement","of","ornithine",",","2",",","5-diaminopentanoic","acid",",","into",",","out","of","or","within","a","mitochondrion","."),4345673). assertion_content_comment('tOboGo_MitochondrialOuterMembrane',s("The","outer",",","i.e",".","cytoplasm-facing",",","lipid","bilayer","of","the","mitochondrial","envelope","."),3980246). assertion_content_comment('tOboGo_MitochondrialOuterMembraneTranslocaseComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","mitochondrial","outer","membrane","translocase","complex","."),4133101). assertion_content_comment('tOboGo_MitochondrialOuterMembraneTranslocaseComplex',s("A","large","complex","of","the","mitochondrial","outer","membrane","that","mediates","transport","of","proteins","into","all","mitochondrial","compartments","."),4007697). assertion_content_comment('tOboGo_MitochondrialOxoglutarateDehydrogenaseComplex',s("A","complex","of","multiple","copies","of","three","enzymatic","components",":","oxoglutarate","dehydrogenase","(","lipoamide",")",";","EC",":","1.2.4.2","(","E1",")",",","dihydrolipoamide","S-succinyltransferase",";","EC",":","2.3.1.61","(","E2",")","and","dihydrolipoamide","dehydrogenase",";","EC",":","1.8.1.4","(","E3",")",";","catalyzes","the","overall","conversion","of","2-oxoglutarate","to","succinyl-CoA","and","carbon","dioxide","(","CO2",")","within","the","mitochondrial","matrix",".","An","example","of","this","complex","is","found","in","Mus","musculus","."),4023778). assertion_content_comment('tOboGo_MitochondrialPart',s("Any","constituent","part","of","a","mitochondrion",",","a","semiautonomous",",","self","replicating","organelle","that","occurs","in","varying","numbers",",","shapes",",","and","sizes","in","the","cytoplasm","of","virtually","all","eukaryotic","cells",".","It","is","notably","the","site","of","tissue","respiration","."),3973883). assertion_content_comment('tOboGo_MitochondrialPermeabilityTransitionPoreComplex',s("A","protein","complex","that","connects","the","inner","and","outer","membranes","of","animal","mitochondria","and","acts","as","a","pore","that","can","open","transiently","to","allow","free","diffusion","of","solutes","between","the","mitochondrial","matrix","and","the","cytosol","."),4007817). assertion_content_comment('tOboGo_MitochondrialProcessingPeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","N-terminal","transit","peptides","from","precursor","proteins","imported","into","the","mitochondrion",",","typically","with","Arg","in","position","P2","."),4210251). assertion_content_comment('tOboGo_MitochondrialProcessingPeptidaseComplex',s("A","protein","complex","that","consists","of","a","catalytic","alpha","subunit","(","alpha-MPP",")","and","a","regulatory","beta","subunit","(","beta-MPP",")",",","and","catalyzes","the","release","of","N-terminal","targeting","peptides","from","precursor","proteins","imported","into","the","mitochondrion","."),4040889). assertion_content_comment('tOboGo_MitochondrialProhibitinComplex',s("A","complex","composed","of","two","proteins",",","prohibitin","1","and","prohibitin","2","(","PHB1/PHB-1","and","PHB2/PHB-2",")","that","is","highly","conserved","amongst","eukaryotes","and","associated","with","the","inner","mitochondrial","membrane",".","The","mitochondrial","prohibitin","complex","is","a","macromolecular","supercomplex","composed","of","repeating","heterodimeric","subunits","of","PHB1","and","PHB2",".","The","mitochondrial","prohibitin","complex","plays","a","role","in","a","number","of","biological","processes",",","including","mitochondrial","biogenesis","and","function",",","development",",","replicative","senescence",",","and","cell","death","."),4081946). assertion_content_comment('tOboGo_MitochondrialProteinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","mitochondrial","protein",".","This","process","is","necessary","to","maintain","the","healthy","state","of","mitochondria","and","is","thought","to","occur","via","the","induction","of","an","intramitochondrial","lysosome-like","organelle","that","acts","to","eliminate","the","damaged","oxidised","mitochondrial","proteins","without","destroying","the","mitochondrial","structure","."),4082553). assertion_content_comment('tOboGo_MitochondrialProteinProcessing',s("The","peptide","cleavage","of","proteins","in","the","mitochondrion",",","including","cleavage","contributing","to","their","import","."),4013818). assertion_content_comment('tOboGo_MitochondrialPyruvateDehydrogenaseComplex',s("Complex","that","carries","out","the","oxidative","decarboxylation","of","pyruvate","to","form","acetyl-CoA","in","eukaryotes",";","includes","subunits","possessing","three","catalytic","activities",":","pyruvate","dehydrogenase","(","E1",")",",","dihydrolipoamide","S-acetyltransferase","(","E2",")",",","and","dihydrolipoamide","dehydrogenase","(","E3",")","The","This","Eukaryotic","form","usually","contains","more","subunits","than","its","bacterial","counterpart",";","for","example",",","one","known","complex","contains","30","E1","dimers",",","60","E2","monomers",",","and","6","E3","dimers","as","well","as","a","few","copies","of","pyruvate","dehydrogenase","kinase","and","pyruvate","dehydrogenase","phosphatase","."),4009193). assertion_content_comment('tOboGo_MitochondrialPyruvateDehydrogenaseLipoamidePhosphataseComplex',s("A","mitochondrial","complex","of","a","regulatory","and","catalytic","subunit","that","catalyzes","the","dephosphorylation","and","concomitant","reactivation","of","the","alpha","subunit","of","the","E1","component","of","the","pyruvate","dehydrogenase","complex",".","An","example","of","this","component","is","found","in","Mus","musculus","."),4042193). assertion_content_comment('tOboGo_MitochondrialPyruvateTransport',s("The","directed","movement","of","pyruvate",",","2-oxopropanoate",",","into",",","out","of","or","within","a","mitochondrion","."),4228616). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","mitochondrial","respiratory","chain","complex","."),4065818). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","mitochondrial","respiratory","chain","complex","I","."),4337105). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIBiogenesis',s("The","biogenesis","of","a","mitochondrial","respiratory","chain","complex","I",",","a","protein","complex","located","in","the","mitochondrial","inner","membrane","that","forms","part","of","the","mitochondrial","respiratory","chain",".","Includes","the","synthesis","of","constituent","proteins","and","their","aggregation",",","arrangement","and","bonding","together","."),4074129). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIIAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","respiratory","chain","complex","II",",","in","the","mitochondrial","inner","membrane","."),4352879). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIIBiogenesis',s("The","biogenesis","of","a","mitochondrial","respiratory","chain","complex","II",",","a","protein","complex","located","in","the","mitochondrial","inner","membrane","that","forms","part","of","the","mitochondrial","respiratory","chain",".","Includes","the","synthesis","of","constituent","proteins","and","their","aggregation",",","arrangement","and","bonding","together","."),4074120). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIIIAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","cytochrome","bc","(","1",")","complex","(","also","known","as","ubiquinol-cytochrome","c","reductase",")",",","in","the","mitochondrial","inner","membrane","."),4352890). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIIIBiogenesis',s("The","biogenesis","of","a","mitochondrial","respiratory","chain","complex","III","(","also","known","as","cytochrome","bc","(","1",")","complex","or","ubiquinol-cytochrome","c","reductase",")",",","a","protein","complex","located","in","the","mitochondrial","inner","membrane","that","forms","part","of","the","mitochondrial","respiratory","chain",".","Includes","the","synthesis","of","constituent","proteins","and","their","aggregation",",","arrangement","and","bonding","together","."),4074110). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIII',s("A","protein","complex","located","in","the","mitochondrial","inner","membrane","that","forms","part","of","the","mitochondrial","respiratory","chain",".","Contains","about","10","polypeptide","subunits","including","four","redox","centers",":","cytochrome","b/b6",",","cytochrome","c1","and","an","2Fe-2S","cluster",".","Catalyzes","the","oxidation","of","ubiquinol","by","oxidized","cytochrome","c1","."),4007468). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexII',s("A","protein","complex","located","in","the","mitochondrial","inner","membrane","that","forms","part","of","the","mitochondrial","respiratory","chain",".","Contains","the","four","polypeptide","subunits","of","succinate","dehydrogenase",",","flavin-adenine","dinucleotide","and","iron-sulfur",".","Catalyzes","the","oxidation","of","succinate","by","ubiquinone",".","Connects","the","TCA","cycle","with","the","respiratory","chain","."),4007567). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIMembraneSegment',s("The","mitochondrial","membrane","segment","of","respiratory","chain","complex","I",".","Respiratory","chain","complex","I","is","an","enzyme","of","the","respiratory","chain",",","consisting","of","at","least","34","polypeptide","chains",".","The","electrons","of","NADH","enter","the","chain","at","this","complex",".","The","complete","complex","is","L-shaped",",","with","a","horizontal","arm","lying","in","the","membrane","and","a","vertical","arm","that","projects","into","the","matrix","."),4077749). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIPeripheralSegment',s("The","peripheral","segment","of","respiratory","chain","complex","I","located","in","the","mitochondrion",".","Respiratory","chain","complex","I","is","an","enzyme","of","the","respiratory","chain",",","consisting","of","at","least","34","polypeptide","chains",".","The","electrons","of","NADH","enter","the","chain","at","this","complex",".","The","complete","complex","is","L-shaped",",","with","a","horizontal","arm","lying","in","the","membrane","and","a","vertical","arm","that","projects","into","the","matrix","."),4077761). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexI',s("A","protein","complex","located","in","the","mitochondrial","inner","membrane","that","forms","part","of","the","mitochondrial","respiratory","chain",".","It","contains","about","25","different","polypeptide","subunits",",","including","NADH","dehydrogenase","(","ubiquinone",")",",","flavin","mononucleotide","and","several","different","iron-sulfur","clusters","containing","non-heme","iron",".","The","iron","undergoes","oxidation-reduction","between","Fe","(","II",")","and","Fe","(","III",")",",","and","catalyzes","proton","translocation","linked","to","the","oxidation","of","NADH","by","ubiquinone","."),4007686). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIVAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","respiratory","chain","complex","IV","(","also","known","as","cytochrome","c","oxidase",")","in","the","mitochondrial","inner","membrane","."),4341581). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIVBiogenesis',s("The","biogenesis","of","a","mitochondrial","respiratory","chain","complex","IV","(","also","known","as","cytochrome","c","oxidase","complex",")",",","a","protein","complex","located","in","the","mitochondrial","inner","membrane","that","forms","part","of","the","mitochondrial","respiratory","chain",".","Includes","the","synthesis","of","constituent","proteins","and","their","aggregation",",","arrangement","and","bonding","together","."),4074223). assertion_content_comment('tOboGo_MitochondrialRespiratoryChainComplexIV',s("A","protein","complex","located","in","the","mitochondrial","inner","membrane","that","forms","part","of","the","mitochondrial","respiratory","chain",".","Contains","the","13","polypeptide","subunits","of","cytochrome","c","oxidase",",","including","cytochrome","a","and","cytochrome","a3",".","Catalyzes","the","oxidation","of","reduced","cytochrome","c","by","dioxygen","(","O2",")"),4007434). assertion_content_comment('tOboGo_MitochondrialRespiratoryChain',s("The","protein","complexes","that","form","the","mitochondrial","electron","transport","system","(","the","respiratory","chain",")",",","associated","with","the","inner","mitochondrial","membrane",".","The","respiratory","chain","complexes","transfer","electrons","from","an","electron","donor","to","an","electron","acceptor","and","are","associated","with","a","proton","pump","to","create","a","transmembrane","electrochemical","gradient","."),4007404). assertion_content_comment('tOboGo_MitochondrialRibonucleasePComplex',s("A","ribonuclease","P","complex","located","in","the","mitochondrion","of","a","eukaryotic","cell",",","where","it","catalyzes","the","5","'","endonucleolytic","cleavage","of","precursor","tRNAs","to","yield","mature","tRNAs",".","The","subunit","composition","of","mitochondrial","ribonuclease","P","complexes","varies","between","species",",","but","the","complex","often","contains","a","single","RNA","molecule","and","a","single","protein","molecule","."),4308281). assertion_content_comment('tOboGo_MitochondrialRibosome',s("A","ribosome","found","in","the","mitochondrion","of","a","eukaryotic","cell",";","contains","a","characteristic","set","of","proteins","distinct","from","those","of","cytosolic","ribosomes","."),4007731). assertion_content_comment('tOboGo_MitochondrialRNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","RNA","transcribed","from","the","mitochondrial","genome","and","occurring","in","the","mitochondrion","."),3979557). assertion_content_comment('tOboGo_MitochondrialRNALocalization',s("Any","process","in","which","mitochondrial","RNA","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4236545). assertion_content_comment('tOboGo_MitochondrialRNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","RNA","transcribed","from","the","mitochondrial","genome","and","occurring","in","the","mitochondrion","."),3979554). assertion_content_comment('tOboGo_MitochondrialRNAPolymeraseBindingPromoterSpecificityActivity',s("An","activity","that","binds","to","mitochondrial","RNA","polymerase","and","which","while","present","in","a","complex","with","the","mitochondrial","RNA","polymerase","confers","sequence","specific","recognition","of","mitochondrial","promoter","DNA","sequence","motifs","."),4359587). assertion_content_comment('tOboGo_MitochondrialRNAPolymeraseRegulatoryRegionDNABinding',s("Interacting","selectively","with","a","DNA","region","that","controls","the","transcription","of","a","region","of","DNA","by","mitochondrial","RNA","polymerase",".","Binding","may","occur","as","a","high","affinity","and","sequence","specific","interaction","or","as","a","lower","affinity","interaction","observed","once","a","factor","has","been","recruited","to","the","DNA","by","other","factors","."),4356365). assertion_content_comment('tOboGo_MitochondrialRNAProcessing',s("The","conversion","of","a","primary","RNA","molecule","transcribed","from","a","mitochondrial","genome","into","one","or","more","mature","RNA","molecules",";","occurs","in","the","mitochondrion","."),4157914). assertion_content_comment('tOboGo_MitochondrialRRNAExportFromMitochondrion',s("The","directed","movement","of","mitochondrial","rRNA","out","of","a","mitochondrion","."),4236551). assertion_content_comment('tOboGo_MitochondrialRRNA',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218383). assertion_content_comment('tOboGo_MitochondrialSingleSubunitTypeRNAPolymeraseActivity',s("Catalysis","of","the","reaction",":","nucleoside","triphosphate","+","RNA","(","n",")","=","diphosphate","+","RNA","(","n","+","1",")","Utilizes","a","DNA","template","that","contains","a","single","subunit","type","mitochondrial","RNA","polymerase","specific","promoter","to","direct","initiation","and","catalyses","DNA-template-directed","extension","of","the","3","'","-end","of","an","RNA","strand","by","one","nucleotide","at","a","time",".","Can","initiate","a","chain","'","de","novo","'"),4355952). assertion_content_comment('tOboGo_MitochondrialSmallRibosomalSubunit',s("The","smaller","of","the","two","subunits","of","a","mitochondrial","ribosome","."),4007755). assertion_content_comment('tOboGo_MitochondrialSodiumCalciumIonExchange',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228662). assertion_content_comment('tOboGo_MitochondrialSortingAndAssemblyMachineryComplex',s("A","large","complex","of","the","mitochondrial","outer","membrane","that","mediates","sorting","of","some","imported","proteins","to","the","outer","membrane","and","their","assembly","in","the","membrane",";","functions","after","import","of","incoming","proteins","by","the","mitochondrial","outer","membrane","translocase","complex","."),3980259). assertion_content_comment('tOboGo_MitochondrialSrRNAExportFromMitochondrion',s("The","directed","movement","of","mitochondrial","srRNA","out","of","a","mitochondrion","."),4236581). assertion_content_comment('tOboGo_MitochondrialTranslationalElongation',s("The","successive","addition","of","amino","acid","residues","to","a","nascent","polypeptide","chain","during","protein","biosynthesis","in","a","mitochondrion","."),4133127). assertion_content_comment('tOboGo_MitochondrialTranslationalInitiation',s("The","process","preceding","formation","of","the","peptide","bond","between","the","first","two","amino","acids","of","a","protein","in","a","mitochondrion",".","This","includes","the","formation","of","a","complex","of","the","ribosome",",","mRNA",",","and","an","initiation","complex","that","contains","the","first","aminoacyl-tRNA","."),4133159). assertion_content_comment('tOboGo_MitochondrialTranslationalTermination',s("The","process","resulting","in","the","release","of","a","polypeptide","chain","from","the","ribosome","in","a","mitochondrion",",","usually","in","response","to","a","termination","codon","(","note","that","mitochondria","use","variants","of","the","universal","genetic","code","that","differ","between","different","taxa",")"),4133138). assertion_content_comment('tOboGo_MitochondrialTranslation',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","protein","in","a","mitochondrion",".","This","is","a","ribosome-mediated","process","in","which","the","information","in","messenger","RNA","(","mRNA",")","is","used","to","specify","the","sequence","of","amino","acids","in","the","protein",";","the","mitochondrion","has","its","own","ribosomes","and","transfer","RNAs",",","and","uses","a","genetic","code","that","differs","from","the","nuclear","code","."),4133112). assertion_content_comment('tOboGo_MitochondrialTranslocation',s("OBSOLETE",".","The","translocation","of","proteins","across","the","mitochondrial","membrane",".","In","the","presence","of","a","translocating","chain",",","the","outer","membrane","import","machinery","(","MOM","complex",")","and","the","inner","membrane","import","machinery","(","MIM","complex",")","form","translocation","contact","sites","as","a","part","of","the","membrane","preprotein","import","machinery","."),4230280). assertion_content_comment('tOboGo_MitochondrialTransport',s("Transport","of","substances","into",",","out","of","or","within","a","mitochondrion","."),4010717). assertion_content_comment('tOboGo_MitochondrialTricarboxylicAcidCycleEnzymeComplex',s("Any","of","the","heteromeric","enzymes",",","located","in","the","mitochondrion",",","that","act","in","the","tricarboxylic","acid","(","TCA",")","cycle","."),4052811). assertion_content_comment('tOboGo_MitochondrialTRNAMethylation',s("The","posttranscriptional","addition","of","methyl","groups","to","specific","residues","in","a","mitochondrial","tRNA","molecule","."),4178130). assertion_content_comment('tOboGo_MitochondrialTRNAModification',s("The","covalent","alteration","of","one","or","more","nucleotides","within","a","mitochondrial","tRNA","molecule","to","produce","a","mitochondrial","tRNA","molecule","with","a","sequence","that","differs","from","that","coded","genetically","."),4158038). assertion_content_comment('tOboGo_MitochondrialTRNAPseudouridineSynthesis',s("The","intramolecular","conversion","of","uridine","to","pseudouridine","in","a","mitochondrial","tRNA","molecule","."),4178109). assertion_content_comment('tOboGo_MitochondrialTRNA',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218373). assertion_content_comment('tOboGo_MitochondrialTRNAThreonylcarbamoyladenosineModification',s("The","attachment","of","a","carbonyl","group","and","a","threonine","to","the","amino","group","of","the","adenine","residue","immediately","3","'","of","the","anticodon",",","in","tRNAs","that","decode","ANN","codons","(","where","N","is","any","base",")"),4158040). assertion_content_comment('tOboGo_MitochondrialTRNAWobbleUridineModification',s("The","process","in","which","a","uridine","in","position","34","of","a","mitochondrial","tRNA","is","post-transcriptionally","modified","."),4178352). assertion_content_comment('tOboGo_MitochondrialTypeIIFattyAcidSynthaseComplex',s("OBSOLETE","A","fatty","acid","synthase","complex","in","which","each","polypeptide","chain","catalyzes","a","single","activity",",","located","in","the","mitochondrion","."),4319760). assertion_content_comment('tOboGo_MitochondrialUnfoldedProteinResponse',s("The","series","of","molecular","signals","generated","as","a","consequence","of","the","presence","of","unfolded","proteins","in","the","mitochondrial","matrix",";","results","in","transcriptional","upregulation","of","nuclear","genes","encoding","mitochondrial","stress","proteins","."),4352128). assertion_content_comment('tOboGo_MitochondrionDegradationByInducedVacuoleFormation',s("The","process","in","which","cells","degrade","mitochondria","by","inducing","a","vacuole-like","structure","which","directly","engulfs","and","degrades","the","unhealthy","mitochondria","by","accumulating","lysosomes","."),4380365). assertion_content_comment('tOboGo_MitochondrionDegradation',s("The","autophagic","process","in","which","mitochondria","are","delivered","to","the","vacuole","and","degraded","in","response","to","changing","cellular","conditions","."),4362557). assertion_content_comment('tOboGo_MitochondrionDistribution',s("Any","process","that","establishes","the","spatial","arrangement","of","mitochondria","between","and","within","cells","."),4077173). assertion_content_comment('tOboGo_MitochondrionInheritance',s("The","distribution","of","mitochondria",",","including","the","mitochondrial","genome",",","into","daughter","cells","after","mitosis","or","meiosis",",","mediated","by","interactions","between","mitochondria","and","the","cytoskeleton","."),4077178). assertion_content_comment('tOboGo_MitochondrionLocalization',s("Any","process","in","which","a","mitochondrion","or","mitochondria","are","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell","."),4077164). assertion_content_comment('tOboGo_MitochondrionMigrationAlongActinFilament',s("The","directed","movement","of","a","mitochondrion","along","a","microfilament",",","mediated","by","motor","proteins","."),4353826). assertion_content_comment('tOboGo_MitochondrionMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","mitochondrion","are","generated","and","organized","."),4175074). assertion_content_comment('tOboGo_MitochondrionOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","mitochondrion",";","includes","mitochondrial","morphogenesis","and","distribution",",","and","replication","of","the","mitochondrial","genome","as","well","as","synthesis","of","new","mitochondrial","components","."),3986794). assertion_content_comment('tOboGo_Mitochondrion',s("A","semiautonomous",",","self","replicating","organelle","that","occurs","in","varying","numbers",",","shapes",",","and","sizes","in","the","cytoplasm","of","virtually","all","eukaryotic","cells",".","It","is","notably","the","site","of","tissue","respiration","."),3973880). assertion_content_comment('tOboGo_MitochondrionTargetingSequenceBinding',s("Interacting","selectively","and","non-covalently","with","a","mitochondrion","targeting","sequence",",","a","specific","peptide","sequence","that","acts","as","a","signal","to","localize","the","protein","within","the","mitochondrion","."),4307444). assertion_content_comment('tOboGo_MitochondrionTransportAlongMicrotubule',s("The","directed","movement","of","a","mitochondrion","along","a","microtubule",",","mediated","by","motor","proteins","."),4369309). assertion_content_comment('tOboGo_Mitosis',s("A","cell","cycle","process","comprising","the","steps","by","which","the","nucleus","of","a","eukaryotic","cell","divides",";","the","process","involves","condensation","of","chromosomal","DNA","into","a","highly","compacted","form",".","Canonically",",","mitosis","produces","two","daughter","nuclei","whose","chromosome","complement","is","identical","to","that","of","the","mother","cell","."),3970447). assertion_content_comment('tOboGo_Mitosome',s("A","double-membrane-bounded","organelle","that","functions","in","iron-sulfur","protein","maturation",";","evolutionarily","derived","from","mitochondria","."),4330219). assertion_content_comment('tOboGo_MitoticAnaphaseA',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","anaphase","A",",","the","part","of","mitotic","anaphase","in","which","the","kinetochore","microtubules","shorten","as","chromosomes","move","toward","the","spindle","poles","."),4345704). assertion_content_comment('tOboGo_MitoticAnaphaseB',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","anaphase","B",",","the","part","of","mitotic","anaphase","in","which","the","polar","microtubules","elongate","and","the","two","poles","of","the","spindle","move","farther","apart","."),4345695). assertion_content_comment('tOboGo_MitoticAnaphase',s("Anaphase","occurring","as","part","of","mitosis",".","Anaphase","is","the","part","of","nuclear","division","in","which","sister","chromatids","(","or","chromosomes",")","separate","and","migrate","towards","the","poles","of","the","spindle",".","Mitosis","is","the","cell","cycle","process","in","which",",","canonically",",","the","nucleus","of","a","eukaryotic","cell","divides","to","produce","two","daughter","nuclei","whose","chromosome","complement","is","identical","to","that","of","the","mother","cell","."),3971202). assertion_content_comment('tOboGo_MitoticCatastrophe',s("A","type","of","programmed","cell","death","that","occurs","during","or","shortly","after","a","dysregulated","or","failed","mitosis","and","can","be","accompanied","by","morphological","alterations","including","micronucleation","and","multinucleation","."),4174361). assertion_content_comment('tOboGo_MitoticCellCycleArrest',s("The","process","in","which","the","mitotic","cell","cycle","is","halted","during","one","of","the","normal","phases","(","G1",",","S",",","G2",",","M",")"),4170941). assertion_content_comment('tOboGo_MitoticCellCycleCheckpoint',s("A","cell","cycle","checkpoint","that","ensures","accurate","chromosome","replication","and","segregation","by","preventing","progression","through","a","mitotic","cell","cycle","until","conditions","are","suitable","for","the","cell","to","proceed","to","the","next","stage","."),4060356). assertion_content_comment('tOboGo_MitoticCellCycleDNAReplicationCheckpoint',s("A","cell","cycle","checkpoint","that","acts","during","a","mitotic","cell","cycle","and","prevents","the","initiation","of","mitosis","until","DNA","replication","is","complete",",","thereby","ensuring","that","progeny","inherit","a","full","complement","of","the","genome","."),4127808). assertion_content_comment('tOboGo_MitoticCellCycleEmbryonic',s("The","eukaryotic","cell","cycle","in","which","a","cell","is","duplicated","without","changing","ploidy",",","occurring","in","the","embryo","."),4019117). assertion_content_comment('tOboGo_MitoticCellCycleG1STransitionCheckpoint',s("A","cell","cycle","checkpoint","that","blocks","entry","into","S","phase","of","the","mitotic","cell","cycle","."),4060385). assertion_content_comment('tOboGo_MitoticCellCycleG1STransitionDNADamageCheckpoint',s("A","mitotic","G1/S","transition","checkpoint","that","blocks","entry","into","S","phase","in","response","to","DNA","damage","."),4128111). assertion_content_comment('tOboGo_MitoticCellCycleG1STransitionSizeControlCheckpoint',s("A","mitotic","cell","cycle","checkpoint","that","blocks","cell","cycle","progression","from","G1","to","S","phase","until","cells","have","reached","a","critical","size","."),4127942). assertion_content_comment('tOboGo_MitoticCellCycleG2MTransitionCheckpoint',s("A","mitotic","cell","cycle","checkpoint","that","blocks","entry","into","M","phase","."),4127653). assertion_content_comment('tOboGo_MitoticCellCycleG2MTransitionDecatenationCheckpoint',s("A","mitotic","cell","cycle","checkpoint","that","blocks","cell","cycle","progression","from","G2","to","M","phase","until","sister","chromatids","are","sufficiently","separated",",","with","concatenated","molecules","topologically","resolved","."),4127656). assertion_content_comment('tOboGo_MitoticCellCycleG2MTransitionDNADamageCheckpoint',s("A","mitotic","cell","cycle","checkpoint","that","blocks","cell","cycle","progression","from","G2","to","M","phase","in","response","to","DNA","damage","."),4128037). assertion_content_comment('tOboGo_MitoticCellCycleSpindleAssemblyCheckpoint',s("A","cell","cycle","checkpoint","that","delays","the","metaphase/anaphase","transition","of","a","mitotic","nuclear","division","until","the","spindle","is","correctly","assembled","and","chromosomes","are","attached","to","the","spindle","."),4127384). assertion_content_comment('tOboGo_MitoticCellCycleSpindleCheckpoint',s("A","cell","cycle","checkpoint","that","delays","the","metaphase/anaphase","transition","of","a","mitotic","nuclear","division","until","the","spindle","is","correctly","assembled","and","oriented",",","and","chromosomes","are","attached","to","the","spindle","."),4127294). assertion_content_comment('tOboGo_MitoticCellCycleSpindleOrientationCheckpoint',s("A","cell","cycle","checkpoint","that","monitors","and","signals","errors","in","the","placement","or","orientation","of","the","spindle","in","the","cell",".","The","result","is","a","cell","cycle","delay",",","usually","in","mitosis",",","until","errors","are","corrected","."),4127297). assertion_content_comment('tOboGo_MitoticCellCycle',s("Progression","through","the","phases","of","the","mitotic","cell","cycle",",","the","most","common","eukaryotic","cell","cycle",",","which","canonically","comprises","four","successive","phases","called","G1",",","S",",","G2",",","and","M","and","includes","replication","of","the","genome","and","the","subsequent","segregation","of","chromosomes","into","daughter","cells",".","In","some","variant","cell","cycles","nuclear","replication","or","nuclear","division","may","not","be","followed","by","cell","division",",","or","G1","and","G2","phases","may","be","absent","."),3969326). assertion_content_comment('tOboGo_MitoticCentrosomeSeparation',s("Separation","of","duplicated","centrosome","components","at","the","beginning","of","mitosis",".","The","centriole","pair","within","each","centrosome","becomes","part","of","a","separate","microtubule","organizing","center","that","nucleates","a","radial","array","of","microtubules","called","an","aster",".","The","two","asters","move","to","opposite","sides","of","the","nucleus","to","form","the","two","poles","of","the","mitotic","spindle","."),4012555). assertion_content_comment('tOboGo_MitoticCheckpointComplex',s("A","multiprotein","complex","that","functions","as","a","mitotic","checkpoint","inhibitor","of","the","anaphase-promoting","complex/cyclosome","(","APC/C",")","In","budding","yeast","this","complex","consists","of","Mad2p",",","Mad3p",",","Bub3p","and","Cdc20p",",","and","in","mammalian","cells","it","consists","of","MAD2",",","BUBR1",",","BUB3",",","and","CDC20","."),4340558). assertion_content_comment('tOboGo_MitoticChromosomeCondensation',s("The","cell","cycle","process","in","which","chromatin","structure","is","compacted","prior","to","and","during","mitosis","in","eukaryotic","cells","."),4012744). assertion_content_comment('tOboGo_MitoticChromosomeDecondensation',s("The","cell","cycle","process","in","which","chromosome","structure","is","altered","from","the","condensed","form","taken","on","during","mitosis","to","the","relaxed","disperse","form","held","in","resting","cells","."),4012949). assertion_content_comment('tOboGo_MitoticChromosomeMovementTowardsSpindlePole',s("The","cell","cycle","process","in","which","the","directed","movement","of","chromosomes","from","the","center","of","the","spindle","towards","the","spindle","poles","occurs",".","This","mediates","by","the","shortening","of","microtubules","attached","to","the","chromosomes",",","during","mitosis","."),4012638). assertion_content_comment('tOboGo_MitoticChromosome',s("OBSOLETE",".","A","chromosome","involved","in","the","process","of","mitosis","."),4219770). assertion_content_comment('tOboGo_MitoticCohesinComplex',s("A","cohesin","complex","that","mediates","sister","chromatid","cohesion","during","mitosis",";","has","a","subunit","composition","distinct","from","that","of","the","meiotic","cohesin","complex","."),4307093). assertion_content_comment('tOboGo_MitoticG1CellCycleArrestInResponseToNitrogenStarvation',s("The","process","in","which","the","mitotic","cell","cycle","is","halted","during","G1","phase",",","as","a","result","of","deprivation","of","nitrogen","."),4170946). assertion_content_comment('tOboGo_MitoticMetaphaseAnaphaseTransition',s("The","cell","cycle","process","in","which","a","cell","progresses","from","metaphase","to","anaphase","during","mitosis",",","triggered","by","the","destruction","of","mitotic","cyclins","."),4012188). assertion_content_comment('tOboGo_MitoticMetaphasePlateCongression',s("The","cell","cycle","process","in","which","chromosomes","are","aligned","at","the","metaphase","plate",",","a","plane","halfway","between","the","poles","of","the","mitotic","spindle",",","during","mitosis","."),4012613). assertion_content_comment('tOboGo_MitoticMetaphase',s("Metaphase","occurring","as","part","of","mitosis",".","Metaphase","is","the","part","of","nuclear","division","in","which",",","canonically",",","chromosomes","become","aligned","on","the","equatorial","plate","of","the","cell",".","Mitosis","is","the","cell","cycle","process","in","which",",","canonically",",","the","nucleus","of","a","eukaryotic","cell","divides","to","produce","two","daughter","nuclei","whose","chromosome","complement","is","identical","to","that","of","the","mother","cell","."),3971222). assertion_content_comment('tOboGo_MitoticNuclearEnvelopeDisassembly',s("The","cell","cycle","process","in","which","the","controlled","breakdown","of","the","nuclear","envelope","during","mitotic","cell","division","occurs","."),4012693). assertion_content_comment('tOboGo_MitoticNuclearEnvelopeReassembly',s("The","cell","cycle","process","that","results","in","reformation","of","the","nuclear","envelope","during","mitotic","cell","division","."),4012859). assertion_content_comment('tOboGo_MitoticNuclearPoreComplexReassembly',s("The","cell","cycle","process","in","which","nuclear","pore","complexes","reform","during","mitotic","cell","division","."),4012918). assertion_content_comment('tOboGo_MitoticPrometaphase',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","prometaphase",",","the","stage","following","prophase","in","mitosis","(","in","higher","eukaryotes",")","during","which","the","nuclear","envelope","is","disrupted","and","breaks","into","membrane","vesicles",",","and","the","spindle","microtubules","enter","the","nuclear","region",".","Kinetochores","mature","on","each","centromere","and","attach","to","some","of","the","spindle","microtubules",".","Kinetochore","microtubules","begin","the","process","of","aligning","chromosomes","in","one","plane","halfway","between","the","poles","."),3973620). assertion_content_comment('tOboGo_MitoticProphase',s("Prophase","occurring","as","part","of","mitosis",".","Prophase","is","the","part","of","nuclear","division","in","which",",","canonically",",","chromosomes","condense","and","the","two","daughter","centrioles","and","their","asters","migrate","toward","the","poles","of","the","cell",".","Mitosis","is","the","cell","cycle","process","in","which",",","canonically",",","the","nucleus","of","a","eukaryotic","cell","divides","to","produce","two","daughter","nuclei","whose","chromosome","complement","is","identical","to","that","of","the","mother","cell","."),3971182). assertion_content_comment('tOboGo_MitoticRecombination',s("The","exchange",",","reciprocal","or","nonreciprocal",",","of","genetic","material","between","one","DNA","molecule","and","a","homologous","region","of","DNA","that","occurs","during","mitotic","cell","cycles","."),3969362). assertion_content_comment('tOboGo_MitoticSeptinComplex',s("A","heterooligomeric","septin","complex","that","acts","during","mitotic","cell","division","."),4329166). assertion_content_comment('tOboGo_MitoticSisterChromatidCohesion',s("The","cell","cycle","process","in","which","the","sister","chromatids","of","a","replicated","chromosome","are","joined","along","the","entire","length","of","the","chromosome",",","from","their","formation","in","S","phase","through","metaphase","during","a","mitotic","cell","cycle",".","This","cohesion","cycle","is","critical","for","high","fidelity","chromosome","transmission","."),4013106). assertion_content_comment('tOboGo_MitoticSisterChromatidSegregation',s("The","cell","cycle","process","in","which","replicated","homologous","chromosomes","are","organized","and","then","physically","separated","and","apportioned","to","two","sets","during","the","mitotic","cell","cycle",".","Each","replicated","chromosome",",","composed","of","two","sister","chromatids",",","aligns","at","the","cell","equator",",","paired","with","its","homologous","partner",".","One","homolog","of","each","morphologic","type","goes","into","each","of","the","resulting","chromosome","sets","."),3970504). assertion_content_comment('tOboGo_MitoticSisterChromatidSeparation',s("The","process","in","which","sister","chromatids","are","physically","detached","from","each","other","during","mitosis","."),4035616). assertion_content_comment('tOboGo_MitoticSpindleDisassembly',s("The","controlled","breakdown","of","the","spindle","during","a","mitotic","cell","cycle","."),4287610). assertion_content_comment('tOboGo_MitoticSpindleElongation',s("Lengthening","of","the","distance","between","poles","of","the","mitotic","spindle","."),3969352). assertion_content_comment('tOboGo_MitoticSpindleOrganizationInNucleus',s("A","process","resulting","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","microtubule","spindle","in","the","nucleus",".","The","process","occurs","during","a","mitotic","cell","cycle","and","takes","place","at","the","cellular","level","."),4310354). assertion_content_comment('tOboGo_MitoticSpindleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","microtubule","spindle","during","a","mitotic","cell","cycle","."),3969328). assertion_content_comment('tOboGo_MitoticSpindleStabilization',s("The","cell","cycle","process","in","which","spindle","integrity","is","maintained","during","M","phase","of","mitosis","."),4317525). assertion_content_comment('tOboGo_MitoticTelophase',s("Telophase","occurring","as","part","of","mitosis",".","Telophase","is","the","part","of","nuclear","division","that",",","canonically",",","begins","when","the","chromosomes","arrive","at","the","poles","of","the","cell","and","the","division","of","the","cytoplasm","starts",".","Mitosis","is","the","cell","cycle","process","in","which",",","canonically",",","the","nucleus","of","a","eukaryotic","cell","divides","to","produce","two","daughter","nuclei","whose","chromosome","complement","is","identical","to","that","of","the","mother","cell","."),3971162). assertion_content_comment('tOboGo_MitralValveDevelopment',s("The","progression","of","the","mitral","valve","over","time",",","from","its","formation","to","the","mature","structure","."),4002168). assertion_content_comment('tOboGo_MitralValveFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","mitral","valve","from","unspecified","parts",".","This","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","discrete","structure","and","ends","when","the","structural","rudiment","is","recognizable","."),4002335). assertion_content_comment('tOboGo_MitralValveMorphogenesis',s("The","process","in","which","the","structure","of","the","mitral","valve","is","generated","and","organized","."),4002178). assertion_content_comment('tOboGo_MLL1Complex',s("A","protein","complex","that","can","methylate","lysine-4","of","histone","H3",".","MLL1/MLL","is","the","catalytic","methyltransferase","subunit",",","and","the","complex","also","contains","the","core","components","ASH2L",",","HCFC1/HCF1","WDR5","and","RBBP5","."),4162328). assertion_content_comment('tOboGo_MMXDComplex',s("A","protein","complex","that","contains","the","proteins","MMS19",",","MIP18","and","XPD",",","localizes","to","mitotic","spindle","during","mitosis",",","and","is","required","for","proper","chromosome","segregation","."),4129491). assertion_content_comment('tOboGo_MnFeSuperoxideDismutase',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4201949). assertion_content_comment('tOboGo_MobileIonCarrierActivity',s("This","is","a","type","of","carrier","produced","by","bacteria",".","It","enable","passive","transport","by","shielding","the","ion","that","is","being","transported","from","the","lipid","membrane",".","It","carries","an","ion","across","the","membrane","by","enclosing","the","ion","and","travelling","across","the","membrane",".","It","does","not","form","a","fully","open","pore","across","the","membrane","."),4331193). assertion_content_comment('tOboGo_ModificationByHostOfSymbiontCellMembrane',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","symbiont","cell","membrane",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4122256). assertion_content_comment('tOboGo_ModificationByHostOfSymbiontCellularComponent',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","symbiont","cellular","component",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4109737). assertion_content_comment('tOboGo_ModificationByHostOfSymbiontCellWall',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","symbiont","cell","wall",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4109752). assertion_content_comment('tOboGo_ModificationByHostOfSymbiontCytoskeleton',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","symbiont","cytoskeleton",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197119). assertion_content_comment('tOboGo_ModificationByHostOfSymbiontMolecularFunction',s("The","process","in","which","an","organism","effects","a","change","in","the","function","of","proteins","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154237). assertion_content_comment('tOboGo_ModificationByHostOfSymbiontMorphologyOrPhysiology',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","processes","of","a","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080232). assertion_content_comment('tOboGo_ModificationByHostOfSymbiontMorphologyOrPhysiologyViaSecretedSubstance',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","symbiont","organism",",","mediated","by","a","substance","secreted","by","one","of","the","organisms",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080273). assertion_content_comment('tOboGo_ModificationByHostOfSymbiontStructure',s("The","process","in","which","an","organism","effects","a","change","in","an","anatomical","part","or","cellular","component","of","the","host","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4109734). assertion_content_comment('tOboGo_ModificationByOrganismOfCellMembraneInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","cell","membrane","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3985816). assertion_content_comment('tOboGo_ModificationByOrganismOfCellWallOfOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","cell","wall","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109748). assertion_content_comment('tOboGo_ModificationByOrganismOfCytoskeletonOfOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","cytoskeleton","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195264). assertion_content_comment('tOboGo_ModificationByOrganismOfSymbiontMorphologyOrPhysiologyViaProteinSecretedByTypeIIISecretionSystem',s("OBSOLETE",".","The","process","by","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","symbiont","organism",",","mediated","by","a","substance","secreted","by","a","type","III","secretion","system","in","the","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188679). assertion_content_comment('tOboGo_ModificationByOrganismOfSymbiontMorphologyOrPhysiologyViaProteinSecretedByTypeIISecretionSystem',s("OBSOLETE",".","The","process","by","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","symbiont","organism",",","mediated","by","a","substance","secreted","by","a","type","II","secretion","system","in","the","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188669). assertion_content_comment('tOboGo_ModificationByOrganismOfSymbiontMorphologyOrPhysiologyViaSubstanceSecretedByTypeIVSecretionSystem',s("OBSOLETE",".","The","process","by","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","symbiont","organism",",","mediated","by","a","substance","secreted","by","a","type","IV","secretion","system","in","the","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188689). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostAnionTransport',s("The","process","in","which","a","symbiont","organism","modulates","the","anion","transport",",","the","directed","movement","of","anions",",","atoms","or","small","molecules","with","a","net","negative","charge",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","of","its","host","organism","."),4288582). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostCellMembrane',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","host","cell","membrane",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3985819). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostCellNucleus',s("The","process","in","which","a","symbiont","organism","effects","a","change","in","the","structure","or","function","of","its","host","cell","nucleus","."),4288568). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostCellularComponent',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","host","cellular","component",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3985805). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostCellWall',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","host","cell","wall",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4120971). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostChloroplastPart',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","component","of","the","host","cell","chloroplast",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341329). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostChloroplast',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","host","cell","chloroplasts",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341327). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostChloroplastThylakoid',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","host","cell","chloroplast","thylakoid",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341347). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostCytoskeleton',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","the","host","cytoskeleton",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195267). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostIntercellularJunctions',s("The","process","in","which","a","symbiont","organism","effects","a","change","in","the","structure","or","function","of","its","host","intercellular","junction",",","a","specialized","region","of","connection","between","two","cells","."),4288557). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMitochondrion',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","host","cell","mitochondria",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341338). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiology',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","processes","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3985679). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaProteinSecretedBySecComplex',s("The","process","in","which","an","organism","(","symbiont",")","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","the","Sec","complex","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080385). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaProteinSecretedByTatComplex',s("The","process","in","which","an","organism","(","symbiont",")","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","the","Tat","complex","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080406). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaProteinSecretedByTypeIIISecretionSystem',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","a","type","III","secretion","system","in","the","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195465). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaProteinSecretedByTypeIISecretionSystem',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","a","type","II","secretion","system","in","the","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195412). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaProteinSecretedByTypeISecretionSystem',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","a","type","I","secretion","system","in","the","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080451). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaProteinSecretedByTypeVIISecretionSystem',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","a","type","VII","secretion","system","in","the","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080365). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaProteinSecretedByTypeVISecretionSystem',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","a","type","VI","secretion","system","in","the","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080345). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaProteinSecretedByTypeVSecretionSystem',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","a","type","V","secretion","system","in","the","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080613). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaSecretedSubstance',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","one","of","the","organisms",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080341). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostMorphologyOrPhysiologyViaSubstanceSecretedByTypeIVSecretionSystem',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","its","host","organism",",","mediated","by","a","substance","secreted","by","a","type","IV","secretion","system","in","the","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195489). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostProteinByPhosphorylation',s("The","process","in","which","an","organism","adds","a","phosphate","group","to","a","protein","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4288848). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostProteinByUbiquitination',s("The","process","in","which","an","organism","adds","one","or","more","ubiquitin","groups","to","a","protein","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154418). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostProtein',s("The","covalent","alteration","by","an","organism","of","one","or","more","amino","acids","occurring","in","proteins",",","peptides","and","nascent","polypeptides","(","co-translational",",","post-translational","modifications",")","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154416). assertion_content_comment('tOboGo_ModificationBySymbiontOfHostStructure',s("The","process","in","which","an","organism","effects","a","change","in","an","anatomical","part","or","cellular","component","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3985791). assertion_content_comment('tOboGo_ModificationByVirusOfHostCellCycleRegulation',s("Interactions",",","directly","with","the","host","cell","macromolecular","machinery",",","to","allow","a","virus","to","modulate","the","rate","of","the","host","cell","cycle","to","facilitate","virus","replication","."),4108297). assertion_content_comment('tOboGo_ModificationByVirusOfHostMRNAProcessing',s("Any","viral","process","that","interferes","with","the","processing","of","mRNA","in","the","host","cell","."),4354770). assertion_content_comment('tOboGo_ModificationByVirusOfHostPolysomes',s("Any","viral","process","that","interferes","with","and","inhibits","the","assembly","and","function","of","polysomes","."),4354809). assertion_content_comment('tOboGo_ModificationOfCellularComponentInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","cellular","component","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3985802). assertion_content_comment('tOboGo_ModificationOfMorphologyOrPhysiologyOfOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","processes","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3985671). assertion_content_comment('tOboGo_ModificationOfMorphologyOrPhysiologyOfOtherOrganism',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","processes","of","a","second","organism","."),3985664). assertion_content_comment('tOboGo_ModificationOfMorphologyOrPhysiologyOfOtherOrganismViaProteinSecretedByTypeIIISecretionSystemInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","second","organism",",","mediated","by","a","substance","secreted","by","a","type","III","secretion","system","in","the","first","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195462). assertion_content_comment('tOboGo_ModificationOfMorphologyOrPhysiologyOfOtherOrganismViaProteinSecretedByTypeIISecretionSystemInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","second","organism",",","mediated","by","a","substance","secreted","by","a","type","II","secretion","system","in","the","first","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195409). assertion_content_comment('tOboGo_ModificationOfMorphologyOrPhysiologyOfOtherOrganismViaSecretedSubstanceInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","second","organism",",","mediated","by","a","substance","secreted","by","one","of","the","organisms",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4080256). assertion_content_comment('tOboGo_ModificationOfMorphologyOrPhysiologyOfOtherOrganismViaSubstanceSecretedByTypeIVSecretionSystemInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","structure","or","function","of","a","second","organism",",","mediated","by","a","substance","secreted","by","a","type","IV","secretion","system","in","the","first","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195486). assertion_content_comment('tOboGo_ModificationOfStructureOfOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","an","anatomical","part","or","cellular","component","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3985788). assertion_content_comment('tOboGo_ModifiedAminoAcidBinding',s("Interacting","selectively","and","non-covalently","with","a","modified","amino","acid","."),4157082). assertion_content_comment('tOboGo_ModifiedAminoAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","modified","amino","acids","from","one","side","of","a","membrane","to","the","other","."),4158518). assertion_content_comment('tOboGo_ModifiedAminoAcidTransport',s("The","directed","movement","of","modified","amino","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4158286). assertion_content_comment('tOboGo_ModulationByHostOfNutrientReleaseFromSymbiont',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","release","of","nutrients","from","a","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110432). assertion_content_comment('tOboGo_ModulationByHostOfSymbiontAdenylateCyclaseActivity',s("Any","process","in","which","the","host","organism","modulates","the","frequency",",","rate","or","extent","of","the","symbiont","adenylate","cyclase","activity",",","which","catalyze","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154243). assertion_content_comment('tOboGo_ModulationByHostOfSymbiontCatalyticActivity',s("The","process","in","which","an","organism","effects","a","change","in","symbiont","enzyme","activity",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154240). assertion_content_comment('tOboGo_ModulationByHostOfSymbiontDefenseResponse',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","resistance","gene-dependent","defense","response","of","the","symbiont",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190765). assertion_content_comment('tOboGo_ModulationByHostOfSymbiontPhagocytosis',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","phagocytosis",",","the","engulfing","by","phagocytes","of","external","particulate","material",",","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186158). assertion_content_comment('tOboGo_ModulationByHostOfSymbiontProteaseActivity',s("The","process","in","which","an","organism","effects","a","change","in","symbiont","protease","activity",",","the","catalysis","of","the","hydrolysis","of","peptide","bonds","in","a","protein",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188042). assertion_content_comment('tOboGo_ModulationByHostOfSymbiontRNALevels',s("The","alteration","by","an","organism","of","the","levels","of","RNA","in","a","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188638). assertion_content_comment('tOboGo_ModulationByHostOfSymbiontSignalTransductionPathway',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","symbiont","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153253). assertion_content_comment('tOboGo_ModulationByHostOfSymbiontTranscription',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","symbiont","transcription",",","the","synthesis","of","either","RNA","on","a","template","of","DNA","or","DNA","on","a","template","of","RNA",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189884). assertion_content_comment('tOboGo_ModulationByHostOfViralTranscription',s("Any","process","in","which","a","host","organism","modulates","the","frequency",",","rate","or","extent","of","viral","transcription",",","the","synthesis","of","either","RNA","on","a","template","of","DNA","or","DNA","on","a","template","of","RNA","."),4328042). assertion_content_comment('tOboGo_ModulationByOrganismOfApoptosisInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","programmed","cell","death","by","apoptosis","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184167). assertion_content_comment('tOboGo_ModulationByOrganismOfBloodCoagulationInOtherOrganism',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","blood","coagulation","in","another","organism",".","Blood","coagulation","is","the","sequential","process","in","which","the","multiple","coagulation","factors","of","the","blood","interact",",","ultimately","resulting","in","the","formation","of","an","insoluble","fibrin","clot","."),4370460). assertion_content_comment('tOboGo_ModulationByOrganismOfDefenseResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","defense","response","of","a","second","organism",",","the","response","mounted","by","that","organism","in","response","to","the","presence","of","the","first","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4120838). assertion_content_comment('tOboGo_ModulationByOrganismOfEntryIntoOtherOrganismViaPhagocytosisInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","to","which","it","enters","into","a","second","organism","via","the","phagocytotic","processes","of","the","other","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4187611). assertion_content_comment('tOboGo_ModulationByOrganismOfEthyleneLevelsInOtherOrganismInvolvedInSymbioticInteraction',s("The","alteration","by","an","organism","of","the","levels","of","ethylene","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4189432). assertion_content_comment('tOboGo_ModulationByOrganismOfEthyleneLevelsInSymbiont',s("OBSOLETE",".","The","alteration","by","an","organism","of","the","levels","of","ethylene","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189422). assertion_content_comment('tOboGo_ModulationByOrganismOfHormoneOrGrowthRegulatorLevelsInOtherOrganismInvolvedInSymbioticInteraction',s("The","alteration","by","an","organism","of","the","levels","of","hormones","or","growth","regulators","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4154643). assertion_content_comment('tOboGo_ModulationByOrganismOfImmuneResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","immune","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction",".","The","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat","."),4184846). assertion_content_comment('tOboGo_ModulationByOrganismOfInducedSystemicResistanceInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","induced","systemic","resistance",",","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184946). assertion_content_comment('tOboGo_ModulationByOrganismOfInducedSystemicResistanceInSymbiont',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","induced","systemic","resistance","in","the","symbiont","organism",";","induced","systemic","resistance","is","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189169). assertion_content_comment('tOboGo_ModulationByOrganismOfInflammatoryResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","inflammatory","response",",","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",",","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195120). assertion_content_comment('tOboGo_ModulationByOrganismOfInnateImmunityInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","innate","immune","response",",","the","first","line","of","defense","against","infection",",","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184870). assertion_content_comment('tOboGo_ModulationByOrganismOfJasmonicAcidLevelsInOtherOrganismInvolvedInSymbioticInteraction',s("The","alteration","by","an","organism","of","the","levels","of","jasmonic","acid","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4189861). assertion_content_comment('tOboGo_ModulationByOrganismOfJasmonicAcidLevelsInSymbiont',s("OBSOLETE",".","The","alteration","by","an","organism","of","the","levels","of","jasmonic","acid","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189851). assertion_content_comment('tOboGo_ModulationByOrganismOfPhytoalexinProductionInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","production","of","phytoalexins","that","occurs","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195767). assertion_content_comment('tOboGo_ModulationByOrganismOfSalicylicAcidLevelsInOtherOrganismInvolvedInSymbioticInteraction',s("The","alteration","by","an","organism","of","the","levels","of","salicylic","acid","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190223). assertion_content_comment('tOboGo_ModulationByOrganismOfSalicylicAcidLevelsInSymbiont',s("OBSOLETE",".","The","alteration","by","an","organism","of","the","levels","of","salicylic","acid","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190213). assertion_content_comment('tOboGo_ModulationByOrganismOfSymbiontApoptosis',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","symbiont",",","where","programmed","cell","death","proceeds","by","apoptosis",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188658). assertion_content_comment('tOboGo_ModulationByOrganismOfSymbiontHormoneOrGrowthRegulatorLevels',s("OBSOLETE",".","The","alteration","by","an","organism","of","the","levels","of","hormones","or","growth","regulators","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197155). assertion_content_comment('tOboGo_ModulationByOrganismOfSymbiontImmuneResponse',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","immune","response","of","the","symbiont","organism",";","the","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186985). assertion_content_comment('tOboGo_ModulationByOrganismOfSymbiontInflammatoryResponse',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","inflammatory","response","of","a","symbiont","organism",";","the","inflammatory","response","is","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189137). assertion_content_comment('tOboGo_ModulationByOrganismOfSymbiontInnateImmunity',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","the","symbiont","organism",";","the","innate","immune","response","is","the","symbiont","'","s","first","line","of","defense","against","infection",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189126). assertion_content_comment('tOboGo_ModulationByOrganismOfSymbiontIntracellularTransport',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","within","the","cell","or","cells","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189158). assertion_content_comment('tOboGo_ModulationByOrganismOfSymbiontPhytoalexinProduction',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","production","of","phytoalexins","as","part","of","the","defense","response","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189530). assertion_content_comment('tOboGo_ModulationByOrganismOfSymbiontProgrammedCellDeath',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","a","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189517). assertion_content_comment('tOboGo_ModulationByOrganismOfSystemicAcquiredResistanceInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","systemic","acquired","resistance",",","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184849). assertion_content_comment('tOboGo_ModulationByOrganismOfSystemicAcquiredResistanceInSymbiont',s("OBSOLETE",".","Any","process","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","systemic","acquired","resistance","in","the","symbiont","organism",";","systemic","acquired","resistance","is","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4189894). assertion_content_comment('tOboGo_ModulationBySymbiontOfAbscisicAcidLevelsInHost',s("The","alteration","by","an","organism","of","the","levels","of","abscisic","acid","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154648). assertion_content_comment('tOboGo_ModulationBySymbiontOfEntryIntoHost',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","to","which","it","enters","into","the","host","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4146026). assertion_content_comment('tOboGo_ModulationBySymbiontOfEntryIntoHostViaPhagocytosis',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","to","which","it","enters","into","the","host",",","via","the","phagocytotic","processes","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190801). assertion_content_comment('tOboGo_ModulationBySymbiontOfEthyleneLevelsInHost',s("The","alteration","by","an","organism","of","the","levels","of","ethylene","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194918). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostAdenylateCyclaseActivity',s("Any","process","in","which","the","symbiont","modulates","the","frequency",",","rate","or","extent","of","the","host","adenylate","cyclase","activity",",","which","involves","catalysis","of","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153107). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostApoptosis',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","host",",","where","programmed","cell","death","proceeds","by","apoptosis",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195226). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostCatalyticActivity',s("The","process","in","which","an","organism","effects","a","change","in","host","enzyme","activity",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153063). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostCellCycle',s("The","process","in","which","a","symbiont","organism","effects","a","change","in","its","host","'","s","cell","cycle","through","direct","interactions","with","the","host","cell","macromolecular","machinery","."),4159785). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostCellularProcess',s("Any","process","in","which","a","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","a","cellular","process",",","any","process","that","is","carried","out","at","the","cellular","level",",","but","not","necessarily","restricted","to","a","single","cell",",","in","its","host","organism","."),4080692). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostDefenseResponse',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","defense","response","of","its","host",",","the","response","mounted","by","the","host","in","response","to","the","presence","of","the","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4120841). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostDigestiveSystemProcess',s("The","alteration","by","a","symbiont","organism","of","the","functioning","of","a","digestive","system","process",",","a","physical",",","chemical",",","or","biochemical","process","carried","out","by","the","host","organism","to","break","down","ingested","nutrients","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),4289050). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostEndocrineProcess',s("The","alteration","by","a","symbiont","organism","of","the","functioning","of","a","endocrine","process",",","any","of","the","hormonal",",","neural",",","and","secretory","processes","that","release","products","into","the","blood","or","lymph",",","in","the","host","organism","."),4289072). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostErythrocyteAggregation',s("Any","process","in","which","a","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","erythrocyte","aggregation","in","its","host","organism",",","e.g",".","the","binding","of","parasite-infected","erythrocytes","to","uninfected","erythrocytes","."),4080697). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostExcretion',s("The","alteration","by","a","symbiont","organism","of","the","functioning","of","excretion",",","the","elimination","by","the","host","organism","of","the","waste","products","that","arise","as","a","result","of","metabolic","activity","."),4288630). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostHormoneOrGrowthRegulatorLevels',s("The","alteration","by","an","organism","of","the","levels","of","hormones","or","growth","regulators","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154646). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostImmuneResponse',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","immune","response","of","the","host","organism",";","the","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4184960). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostInducedSystemicResistance',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","induced","systemic","resistance","in","the","host","organism",";","induced","systemic","resistance","is","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4184962). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostInflammatoryResponse',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","inflammatory","response","of","the","host","organism",";","the","inflammatory","response","is","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195123). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostInnateImmunity',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","the","host","organism",";","the","innate","immune","response","is","the","host","'","s","first","line","of","defense","against","infection",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190568). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostIntracellularTransport',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","within","the","cell","or","cells","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195291). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostMolecularFunction',s("The","process","in","which","an","organism","effects","a","change","in","the","function","of","a","host","protein","via","a","direct","interaction",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153011). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostNeurologicalSystemProcess',s("The","alteration","by","a","symbiont","organism","of","the","functioning","of","a","host","neurophysiological","process",",","an","organ","system","process","carried","out","by","any","of","the","organs","or","tissues","of","neurological","system","."),4288606). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostNeurotransmitterSecretion',s("Any","process","in","which","a","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","neurotransmitter","from","a","cell","or","group","of","cells","in","its","host","organism","."),4288696). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostPhagocytosis',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","phagocytosis",",","the","engulfing","by","phagocytes","of","external","particulate","material",",","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195640). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostPhytoalexinProduction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","production","of","phytoalexins","as","part","of","the","defense","response","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195803). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostProgrammedCellDeath',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121136). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostProteaseActivity',s("The","process","in","which","an","organism","effects","a","change","in","host","protease","activity",",","the","catalysis","of","the","hydrolysis","of","peptide","bonds","in","a","protein",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195432). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostProteinLevels',s("The","alteration","by","an","organism","of","protein","levels","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154601). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostRespiratorySystemProcess',s("The","alteration","by","a","symbiont","organism","of","the","functioning","of","a","respiratory","system","process",",","an","organ","system","process","carried","out","by","any","of","the","organs","or","tissues","of","the","respiratory","system","."),4288618). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostResponseToAbioticStimulus',s("Any","process","in","which","an","organism","modulates","a","change","in","the","state","or","activity","of","a","host","cell","or","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","an","abiotic","(","non-living",")","stimulus",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341492). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostResponseToCold',s("Any","process","in","which","an","organism","modulates","a","change","in","state","or","activity","of","a","host","cell","or","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","cold","stimulus",",","a","temperature","stimulus","below","the","optimal","temperature","for","that","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341511). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostResponseToGravitationalStimulus',s("Any","process","in","which","an","organism","modulates","a","change","in","state","or","activity","of","a","host","cell","or","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","gravitational","stimulus",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341549). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostResponseToHeat',s("Any","process","in","which","an","organism","modulates","a","change","in","state","or","activity","of","a","host","cell","or","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","heat","stimulus",",","a","temperature","stimulus","above","the","optimal","temperature","for","that","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341521). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostResponseToOsmoticStress',s("Any","process","in","which","an","organism","modulates","a","change","in","state","or","activity","of","a","host","cell","or","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","stimulus","indicating","an","increase","or","decrease","in","the","concentration","of","solutes","outside","the","organism","or","cell",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341540). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostResponseToPH',s("Any","process","in","which","an","organism","modulates","a","change","in","state","or","activity","of","a","host","cell","or","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","pH","stimulus",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341559). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostResponseToTemperatureStimulus',s("Any","process","in","which","an","organism","modulates","a","change","in","state","or","activity","of","a","host","cell","or","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","temperature","stimulus",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341501). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostResponseToWater',s("Any","process","in","which","an","organism","modulates","a","change","in","state","or","activity","of","a","host","cell","or","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","water","stimulus",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4341531). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostRhoProteinSignalTransduction',s("Any","process","in","which","a","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","Rho","protein","signal","transduction","in","its","host","organism","."),4288746). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostSignalTransductionPathway',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","host","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4083779). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostSmallGTPaseMediatedSignalTransduction',s("Any","process","in","which","a","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","small","GTPase","mediated","signal","transduction","in","its","host","organism","."),4288742). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostSystemicAcquiredResistance',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","systemic","acquired","resistance","in","the","host","organism",";","systemic","acquired","resistance","is","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4185088). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostSystemProcess',s("The","alteration","by","a","symbiont","organism","of","the","functioning","of","a","system","process","in","the","host",".","A","system","process","is","a","multicellular","organismal","process","carried","out","by","any","of","the","organs","or","tissues","in","an","organ","system","."),4288603). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostTranscription',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","host","transcription",",","the","synthesis","of","either","RNA","on","a","template","of","DNA","or","DNA","on","a","template","of","RNA",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194929). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostTranslation',s("The","process","in","which","a","symbiont","organism","effects","a","change","in","translation",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","protein",",","in","its","host","organism","."),4236791). assertion_content_comment('tOboGo_ModulationBySymbiontOfHostVacuoleOrganization',s("Any","process","in","which","a","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","vacuole","organization","in","its","host","organism","."),4288649). assertion_content_comment('tOboGo_ModulationBySymbiontOfIndoleAceticAcidLevelsInHost',s("The","alteration","by","an","organism","of","the","levels","of","indole","acetic","acid","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4288858). assertion_content_comment('tOboGo_ModulationBySymbiontOfJasmonicAcidLevelsInHost',s("The","alteration","by","an","organism","of","the","levels","of","jasmonic","acid","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194907). assertion_content_comment('tOboGo_ModulationBySymbiontOfNutrientReleaseFromHost',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","release","of","nutrients","from","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121158). assertion_content_comment('tOboGo_ModulationBySymbiontOfRNALevelsInHost',s("The","alteration","by","an","organism","of","the","levels","of","RNA","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4108212). assertion_content_comment('tOboGo_ModulationBySymbiontOfSalicylicAcidLevelsInHost',s("The","alteration","by","an","organism","of","the","levels","of","salicylic","acid","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194896). assertion_content_comment('tOboGo_ModulationByVirusOfHostCellCycle',s("Any","viral","process","that","modulates","the","rate","or","extent","of","progression","through","the","cell","cycle","."),4159790). assertion_content_comment('tOboGo_ModulationByVirusOfHostCellularProcess',s("The","process","in","which","a","virus","effects","a","change","in","the","cellular","pathways","and","activities","of","its","host","organism","."),4108171). assertion_content_comment('tOboGo_ModulationByVirusOfHostTranscription',s("The","modulation","by","viral","gene","products","of","host","RNA","polymerase","II","facilitated","transcription","."),4236770). assertion_content_comment('tOboGo_ModulationOfCatalyticActivityInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","enzyme","activity","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4153060). assertion_content_comment('tOboGo_ModulationOfDevelopmentOfSymbiontInvolvedInInteractionWithHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","progression","of","an","organism","from","an","initial","condition","to","a","later","condition",",","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4097494). assertion_content_comment('tOboGo_ModulationOfDevelopmentOfSymbiontOnOrNearHost',s("Any","process","in","which","the","symbiont","regulates","its","progression","from","an","initial","condition","to","a","later","condition",",","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4097498). assertion_content_comment('tOboGo_ModulationOfEncystedZoosporeGerminationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","encysted","zoospore","germination","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146304). assertion_content_comment('tOboGo_ModulationOfGermTubeFormationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","germ","tube","formation","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147351). assertion_content_comment('tOboGo_ModulationOfGrowthOfSymbiontInvolvedInInteractionWithHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","increase","in","size","or","mass","of","an","organism","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4097556). assertion_content_comment('tOboGo_ModulationOfGrowthOfSymbiontOnOrNearHost',s("Any","process","in","which","the","symbiont","regulates","the","increase","in","its","size","or","mass","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4097560). assertion_content_comment('tOboGo_ModulationOfGrowthOrDevelopmentOfSymbiontDuringInteractionWithHost',s("OBSOLETE",".","Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","increase","in","size","or","mass","of","an","organism",",","or","the","progression","of","an","organism","from","an","initial","condition","to","a","later","condition",",","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4154557). assertion_content_comment('tOboGo_ModulationOfGrowthOrDevelopmentOfSymbiontOnOrNearHost',s("OBSOLETE",".","Any","process","by","which","the","symbiont","regulates","the","increase","in","its","size","or","mass",",","or","its","progression","from","an","initial","condition","to","a","later","condition",",","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4154683). assertion_content_comment('tOboGo_ModulationOfHostTranslationByVirus',s("Any","process","in","which","a","virus","modulates","the","frequency",",","rate","or","extent","of","translation","of","host","mRNA","."),4236796). assertion_content_comment('tOboGo_ModulationOfIntracellularTransportInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","within","the","cell","or","cells","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195287). assertion_content_comment('tOboGo_ModulationOfMicrotubuleCytoskeletonInvolvedInCerebralCortexRadialGliaGuidedMigration',s("Rearrangements","of","the","microtubule","cytoskeleton","that","contribute","to","the","movement","of","cells","along","radial","glial","cells","as","a","component","of","the","process","of","cerebral","cortex","glial-mediated","radial","migration","."),4049729). assertion_content_comment('tOboGo_ModulationOfMolecularFunctionInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","the","function","of","proteins","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4153006). assertion_content_comment('tOboGo_ModulationOfNutrientReleaseFromOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","release","of","nutrients","from","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4110409). assertion_content_comment('tOboGo_ModulationOfPhagocytosisInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","phagocytosis",",","the","engulfing","by","phagocytes","of","external","particulate","material",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4186132). assertion_content_comment('tOboGo_ModulationOfProgrammedCellDeathInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4110231). assertion_content_comment('tOboGo_ModulationOfProteaseActivityInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","effects","a","change","in","protease","activity",",","the","catalysis","of","the","hydrolysis","of","peptide","bonds","in","a","protein",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4188021). assertion_content_comment('tOboGo_ModulationOfRNALevelsInOtherOrganismInvolvedInSymbioticInteraction',s("The","alteration","by","an","organism","of","the","levels","of","RNA","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4108209). assertion_content_comment('tOboGo_ModulationOfSignalTransductionPathwayInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",",","occurring","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4083776). assertion_content_comment('tOboGo_ModulationOfSporangiumGerminationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","sporangium","germination",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146383). assertion_content_comment('tOboGo_ModulationOfSporeEncystmentOnHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","spore","encystment","on","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146195). assertion_content_comment('tOboGo_ModulationOfSporeGerminationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","spore","germination","on","or","near","host",",","which","is","the","physiological",",","developmental","and","morphological","changes","that","occur","in","a","symbiont","spore","following","release","from","dormancy","up","to","the","earliest","signs","of","growth","occurring","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146301). assertion_content_comment('tOboGo_ModulationOfSporeMovementOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","spore","movement","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146473). assertion_content_comment('tOboGo_ModulationOfSymbiontCellWallStrengtheningInvolvedInEntryIntoHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","cell","wall","strengthening","during","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147087). assertion_content_comment('tOboGo_ModulationOfSymbiontGermTubeHookStructureFormationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","germ","tube","hook","structure","formation","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147429). assertion_content_comment('tOboGo_ModulationOfSymbiontHaustoriumNeckFormationForEntryIntoHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","haustorium","neck","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146054). assertion_content_comment('tOboGo_ModulationOfSymbiontPenetrationHyphaFormationForEntryIntoHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","penetration","hypha","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146029). assertion_content_comment('tOboGo_ModulationOfSymbiontPenetrationPegFormationForEntryIntoHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","penetration","peg","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147217). assertion_content_comment('tOboGo_ModulationOfSymbiontPenetrationPegInitiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","penetration","peg","initiation",",","the","process","in","which","a","relatively","unspecialized","cell","start","to","acquire","the","characteristics","of","a","mature","penetration","peg","when","the","symbiont","penetrates","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147233). assertion_content_comment('tOboGo_ModulationOfTheMicrofilamentCytoskeletonInvolvedInCellLocomotionInCerebralCortexRadialGliaGuidedMigration',s("The","changes","in","the","actin","cytoskeleton","that","are","necessary","for","the","movement","of","cells","along","radial","glial","cells","as","a","component","of","the","process","of","cerebral","cortex","glial-mediated","radial","cell","migration","."),4050003). assertion_content_comment('tOboGo_ModulationOfTranscriptionInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","transcription",",","the","synthesis","of","either","RNA","on","a","template","of","DNA","or","DNA","on","a","template","of","RNA",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4189881). assertion_content_comment('tOboGo_ModulationOfZoosporeEncystmentOnHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","zoospore","encystment","on","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146236). assertion_content_comment('tOboGo_ModulationOfZoosporeMovementOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","zoospore","movement","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146540). assertion_content_comment('tOboGo_Molecular_Function',s("Elemental","activities",",","such","as","catalysis","or","binding",",","describing","the","actions","of","a","gene","product","at","the","molecular","level",".","A","given","gene","product","may","exhibit","one","or","more","molecular","functions","."),3968897). assertion_content_comment('tOboGo_MolecularHydrogenTransport',s("The","directed","movement","of","molecular","hydrogen","(","H2",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4295106). assertion_content_comment('tOboGo_MolecularTransducerActivity',s("The","molecular","function","that","accepts","an","input","of","one","form","and","creates","an","output","of","a","different","form","."),4071545). assertion_content_comment('tOboGo_MoltingCycleProcess',s("A","multicellular","organismal","process","involved","in","the","periodic","casting","off","and","regeneration","of","an","outer","covering","of","cuticle",",","feathers",",","hair",",","horns",",","skin","."),4015231). assertion_content_comment('tOboGo_MoltingCycle',s("The","periodic","casting","off","and","regeneration","of","an","outer","covering","of","cuticle",",","feathers",",","hair",",","horns",",","skin",",","etc","."),4015229). assertion_content_comment('tOboGo_MolybdateIonBinding',s("Interacting","selectively","and","non-covalently","with","molybdate","(","MoO4","2-",")","ions","."),4307295). assertion_content_comment('tOboGo_MolybdateIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","molybdate","(","MoO4","2-",")","ions","from","one","side","of","a","membrane","to","the","other",".","Molybdate","is","the","bivalent","anion","derived","from","molybdic","acid","."),4291482). assertion_content_comment('tOboGo_MolybdateIonTransport',s("The","directed","movement","of","molybdate","(","MoO4","2-",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Molybdate","is","the","bivalent","anion","derived","from","molybdic","acid","."),4290085). assertion_content_comment('tOboGo_MolybdenumIonBinding',s("Interacting","selectively","and","non-covalently","with","molybdenum","(","Mo",")","ions","."),4311076). assertion_content_comment('tOboGo_MolybdenumIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","molybdenum","(","Mo",")","ions","from","one","side","of","a","membrane","to","the","other","."),4314976). assertion_content_comment('tOboGo_MolybdopterinCofactorBinding',s("Interacting","selectively","and","non-covalently","with","the","molybdopterin","cofactor","(","Moco",")",",","essential","for","the","catalytic","activity","of","some","enzymes",",","e.g",".","sulfite","oxidase",",","xanthine","dehydrogenase",",","and","aldehyde","oxidase",".","The","cofactor","consists","of","a","mononuclear","molybdenum","(","Mo-molybdopterin",")","or","tungsten","ion","(","W-molybdopterin",")","coordinated","by","one","or","two","molybdopterin","ligands","."),4325518). assertion_content_comment('tOboGo_MolybdopterinCofactorBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","molybdopterin","cofactor","(","Moco",")",",","essential","for","the","catalytic","activity","of","some","enzymes",",","e.g",".","sulfite","oxidase",",","xanthine","dehydrogenase",",","and","aldehyde","oxidase",".","The","cofactor","consists","of","a","mononuclear","molybdenum","(","Mo-molybdopterin",")","or","tungsten","ion","(","W-molybdopterin",")","coordinated","by","one","or","two","molybdopterin","ligands","."),4230093). assertion_content_comment('tOboGo_MolybdopterinCofactorCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","molybdopterin","cofactor","(","Moco",")",",","essential","for","the","catalytic","activity","of","some","enzymes",",","e.g",".","sulfite","oxidase",",","xanthine","dehydrogenase",",","and","aldehyde","oxidase",".","The","cofactor","consists","of","a","mononuclear","molybdenum","(","Mo-molybdopterin",")","or","tungsten","ion","(","W-molybdopterin",")","coordinated","by","one","or","two","molybdopterin","ligands","."),4333761). assertion_content_comment('tOboGo_MolybdopterinCofactorMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","molybdopterin","cofactor","(","Moco",")",",","essential","for","the","catalytic","activity","of","some","enzymes",",","e.g",".","sulfite","oxidase",",","xanthine","dehydrogenase",",","and","aldehyde","oxidase",".","The","cofactor","consists","of","a","mononuclear","molybdenum","(","Mo-molybdopterin",")","or","tungsten","ion","(","W-molybdopterin",")","coordinated","by","one","or","two","molybdopterin","ligands","."),4230073). assertion_content_comment('tOboGo_MolybdopterinSynthaseComplex',s("A","protein","complex","that","possesses","molybdopterin","synthase","activity",".","In","E",".","coli",",","the","complex","is","a","heterotetramer","consisting","of","two","MoaD","and","two","MoaE","subunits","."),4236468). assertion_content_comment('tOboGo_MonoacylglycerolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","monoacylglycerol",",","any","ester","of","glycerol","in","which","any","one","of","its","hydroxyl","groups","has","been","acylated","with","a","fatty","acid",",","the","other","being","non-esterified","."),4230473). assertion_content_comment('tOboGo_MonoacylglycerolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","monoacylglycerol",",","any","ester","of","glycerol","in","which","any","one","of","its","hydroxyl","groups","has","been","acylated","with","a","fatty","acid",",","the","other","being","non-esterified","."),4191802). assertion_content_comment('tOboGo_MonoacylglycerolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","monoacylglycerol",",","any","ester","of","glycerol","in","which","any","one","of","its","hydroxyl","groups","has","been","acylated","with","a","fatty","acid",",","the","other","being","non-esterified","."),4191796). assertion_content_comment('tOboGo_Monoamine_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","H","+","(","out",")","+","monoamine","(","in",")","=","H","+","(","in",")","+","monoamine","(","out",")"),4296500). assertion_content_comment('tOboGo_MonoamineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","monoamines",",","organic","compounds","that","contain","one","amino","group","that","is","connected","to","an","aromatic","ring","by","an","ethylene","group","(","-CH2-CH2-",")",",","from","one","side","of","the","membrane","to","the","other","."),4216224). assertion_content_comment('tOboGo_MonoamineTransport',s("The","directed","movement","of","monoamines",",","organic","compounds","that","contain","one","amino","group","that","is","connected","to","an","aromatic","ring","by","an","ethylene","group","(","-CH2-CH2-",")",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3993560). assertion_content_comment('tOboGo_MonocarboxylateChannelActivity',"OBSOLETE.",4295409). assertion_content_comment('tOboGo_MonocarboxylateLactatePyruvateMevalonateUptakeEffluxPorterActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4296079). assertion_content_comment('tOboGo_MonocarboxylicAcidBinding',s("Interacting","selectively","and","non-covalently","with","a","monocarboxylic","acid",",","any","organic","acid","containing","one","carboxyl","(","COOH",")","group","or","anion","(","COO-",")"),4174486). assertion_content_comment('tOboGo_MonocarboxylicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","monocarboxylic","acids",",","any","organic","acid","containing","one","carboxyl","(","-COOH",")","group","."),4158751). assertion_content_comment('tOboGo_MonocarboxylicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","monocarboxylic","acids",",","any","organic","acid","containing","one","carboxyl","(","-COOH",")","group","."),4057919). assertion_content_comment('tOboGo_MonocarboxylicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","monocarboxylic","acids",",","any","organic","acid","containing","one","carboxyl","(","COOH",")","group","or","anion","(","COO-",")"),4022287). assertion_content_comment('tOboGo_MonocarboxylicAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","monocarboxylic","acids","from","one","side","of","the","membrane","to","the","other",".","A","monocarboxylic","acid","is","an","organic","acid","with","one","COOH","group","."),4170100). assertion_content_comment('tOboGo_MonocarboxylicAcidTransport',s("The","directed","movement","of","monocarboxylic","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4024589). assertion_content_comment('tOboGo_MonocyteActivationInvolvedInImmuneResponse',s("The","change","in","morphology","and","behavior","of","a","monocyte","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4378497). assertion_content_comment('tOboGo_MonocyteActivation',s("The","change","in","morphology","and","behavior","of","a","monocyte","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),4313894). assertion_content_comment('tOboGo_MonocyteAggregation',s("The","adhesion","of","one","monocyte","to","one","or","more","other","monocytes","via","adhesion","molecules","."),4175795). assertion_content_comment('tOboGo_MonocyteAntigenProcessingAndPresentation',s("The","process","in","which","a","monocyte","expresses","antigen","(","peptide","or","lipid",")","on","its","cell","surface","in","association","with","an","MHC","protein","complex","."),3994581). assertion_content_comment('tOboGo_MonocyteChemotaxis',s("The","movement","of","a","monocyte","in","response","to","an","external","stimulus","."),4149839). assertion_content_comment('tOboGo_MonocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","myeloid","precursor","cell","acquires","the","specialized","features","of","a","monocyte","."),4087304). assertion_content_comment('tOboGo_MonocyteExtravasation',s("The","migration","of","a","monocyte","from","the","blood","vessels","into","the","surrounding","tissue","."),4142015). assertion_content_comment('tOboGo_MonocyteHomeostasis',s("The","process","of","regulating","the","proliferation","and","elimination","of","monocytes","such","that","the","total","number","of","monocytes","within","a","whole","or","part","of","an","organism","is","stable","over","time","in","the","absence","of","an","outside","stimulus","."),4381017). assertion_content_comment('tOboGo_MonocyteMigrationIntoBloodStream',s("The","movement","of","a","monocyte","from","the","bone","marrow","to","the","blood","stream","."),4082542). assertion_content_comment('tOboGo_MonodehydroascorbateReductaseNADHActivity',s("Catalysis","of","the","reaction",":","NADH","+","H","+","+","2","monodehydroascorbate","=","NAD","+","+","2","ascorbate","."),4305672). assertion_content_comment('tOboGo_MonodemethylisoproturonDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","monodemethylisoproturon","+","H2O","=","hydroxymonodemethylisoproturon","+","2","H","+","+","2","e-","."),4352606). assertion_content_comment('tOboGo_MonodemethylisoproturonDimethylaminedehydrogenaseActivity',s("Catalysis","of","the","reaction",":","monodemethylisoproturon","+","H2O","=","didemethylisoproturon","+","formaldehyde","+","2","H","+","+","2","e-","."),4352660). assertion_content_comment('tOboGo_MonohemeClassICytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4258961). assertion_content_comment('tOboGo_MonomericIgAImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","an","IgA","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",",","and","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169798). assertion_content_comment('tOboGo_MonomethylamineMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","monomethylamine","+","a","monomethylamine","corrinoid","protein","=","a","methylated","monomethylamine","corrinoid","protein","+","NH3","."),4326883). assertion_content_comment('tOboGo_Mononeme',s("A","secretory","organelle","that","forms","part","of","the","apical","complex",";","a","small",",","threadlike","structure","located","is","close","proximity","to","the","subpellicular","microtubules",".","Its","contents","include","a","rhomboid","protease","(","PfROM1","in","Plasmodium","falciparum",")","that","moves","from","the","lateral","asymmetric","localization","to","the","merozoite","apical","pole","and","the","posterior","pole","upon","release","of","merozoites","from","schizonts","."),4133879). assertion_content_comment('tOboGo_MononuclearCellMigration',s("The","movement","of","a","mononuclear","cell","within","or","between","different","tissues","and","organs","of","the","body","."),4025031). assertion_content_comment('tOboGo_MononuclearCellProliferation',s("The","expansion","of","a","mononuclear","cell","population","by","cell","division",".","A","mononuclear","cell","is","a","leukocyte","with","a","single","non-segmented","nucleus","in","the","mature","form","."),3984847). assertion_content_comment('tOboGo_MononuclearIronElectronCarrier',s("OBSOLETE",".","A","mononuclear","iron","entity","that","serves","as","an","electron","acceptor","and","electron","donor","in","an","electron","transport","system","."),4259496). assertion_content_comment('tOboGo_MonooxygenaseActivity',s("Catalysis","of","the","incorporation","of","one","atom","from","molecular","oxygen","into","a","compound","and","the","reduction","of","the","other","atom","of","oxygen","to","water","."),4073673). assertion_content_comment('tOboGo_MonophenolMonooxygenaseActivatorActivity',s("OBSOLETE",".","Increases","the","activity","of","the","enzyme","monophenol","monooxygenase","."),4253658). assertion_content_comment('tOboGo_MonophenolMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","L-tyrosine","+","L-DOPA","+","O2","=","L-DOPA","+","DOPAquinone","+","H2O","."),4205370). assertion_content_comment('tOboGo_MonopolarCellGrowth',s("Polarized","growth","from","one","end","of","a","cell","."),4118649). assertion_content_comment('tOboGo_MonopolinComplex',s("A","protein","complex","required","for","clamping","microtubule","binding","sites",",","ensuring","orientation","of","sister","kinetochores","to","the","same","pole","(","mono-orientation",")","during","meiosis","I",".","In","the","yeast","S",".","cerevisiae","this","complex","consists","of","Csm1p",",","Lrs4p",",","Hrr25p","and","Mam1p",";","in","S",".","pombe","Psc1","and","Mde4","have","been","identified","as","subunits","."),4063365). assertion_content_comment('tOboGo_MonoprenylIsoflavoneEpoxidaseActivity',s("Catalysis","of","the","reaction",":","O2","+","NADPH","+","H","+","+","7-O-methylluteone","=","H2O","+","NADP","+","+","dihydrofurano","derivatives","."),4278251). assertion_content_comment('tOboGo_MonosaccharideBinding',s("Interacting","selectively","and","non-covalently","with","any","monosaccharide",".","Monosaccharides","are","the","simplest","carbohydrates",";","they","are","polyhydroxy","aldehydes","H","[","CH","(","OH",")","]","nC","(","=","O",")","H","or","polyhydroxy","ketones","H","[","CHOH","]","nC","(","=","O",")","[","CHOH","]","mH","with","three","or","more","carbon","atoms",".","They","form","the","constitutional","repeating","units","of","oligo-","and","polysaccharides","."),4180071). assertion_content_comment('tOboGo_MonosaccharideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","monosaccharides",",","polyhydric","alcohols","containing","either","an","aldehyde","or","a","keto","group","and","between","three","to","ten","or","more","carbon","atoms","."),4010476). assertion_content_comment('tOboGo_MonosaccharideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","monosaccharides",",","polyhydric","alcohols","containing","either","an","aldehyde","or","a","keto","group","and","between","three","to","ten","or","more","carbon","atoms","."),4010413). assertion_content_comment('tOboGo_MonosaccharideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","monosaccharides",",","the","simplest","carbohydrates",".","They","are","polyhydric","alcohols","containing","either","an","aldehyde","or","a","keto","group","and","between","three","to","ten","or","more","carbon","atoms",".","They","form","the","constitutional","repeating","units","of","oligo-","and","polysaccharides","."),4008976). assertion_content_comment('tOboGo_MonosaccharideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","monosaccharide","from","one","side","of","a","membrane","to","the","other","."),4020393). assertion_content_comment('tOboGo_MonosaccharideTransport',s("The","directed","movement","of","monosaccharides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Monosaccharides","are","the","simplest","carbohydrates",";","they","are","polyhydric","alcohols","containing","either","an","aldehyde","or","a","keto","group","and","between","three","to","ten","or","more","carbon","atoms",".","They","form","the","constitutional","repeating","units","of","oligo-","and","polysaccharides","."),4036535). assertion_content_comment('tOboGo_MonosialogangliosideSialyltransferaseActivity',s("Catalysis","of","the","reaction",":","D-galactosyl-N-acetyl-D-galactosaminyl-","(","N-acetylneuraminyl",")","-D-galactosyl-D-glucosylceramide","+","CMP-N-acetylneuraminate","=","N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-","(","N-acetylneuraminyl",")","-D-galactosyl-D-glucosylceramide","+","CMP","."),4367400). assertion_content_comment('tOboGo_MonoterpeneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","monoterpenes",",","terpenes","with","a","C10","structure","."),4321913). assertion_content_comment('tOboGo_MonoterpeneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","monoterpenes",",","terpenes","with","a","C10","structure","."),4239774). assertion_content_comment('tOboGo_MonoterpeneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","monoterpenes",",","terpenes","with","a","C10","structure","."),4239755). assertion_content_comment('tOboGo_MonoterpenoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","monoterpenoid","compounds",",","terpenoids","having","a","C10","skeleton","."),4303335). assertion_content_comment('tOboGo_MonoterpenoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","monoterpenoid","compounds",",","terpenoids","having","a","C10","skeleton","."),4303275). assertion_content_comment('tOboGo_MonoterpenoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","monoterpenoid","compounds",",","terpenoids","having","a","C10","skeleton","."),4244131). assertion_content_comment('tOboGo_MonoubiquitinatedHistoneDeubiquitination',s("The","removal","of","the","ubiquitin","group","from","a","monoubiquitinated","histone","protein","."),4379041). assertion_content_comment('tOboGo_MonoubiquitinatedHistoneH2ADeubiquitination',s("The","removal","of","the","ubiquitin","group","from","a","monoubiquitinated","histone","H2A","protein","."),4379045). assertion_content_comment('tOboGo_MonoubiquitinatedProteinDeubiquitination',s("The","removal","of","the","ubiquitin","group","from","a","monoubiquitinated","protein","."),4379037). assertion_content_comment('tOboGo_MonovalentAnion_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","monovalent","anion","(","out",")","+","Na","+","(","out",")","=","monovalent","anion","(","in",")","+","Na","+","(","in",")"),4254743). assertion_content_comment('tOboGo_MonovalentCation_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","monovalent","cation","(","out",")","+","H","+","(","in",")","=","monovalent","cation","(","in",")","+","H","+","(","out",")"),4219495). assertion_content_comment('tOboGo_MonovalentInorganicAnionHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","monovalent","inorganic","anions","within","an","organism","or","cell","."),4174051). assertion_content_comment('tOboGo_MonovalentInorganicCationHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","monovalent","inorganic","cations","within","an","organism","or","cell","."),4069965). assertion_content_comment('tOboGo_MonovalentInorganicCationTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","inorganic","cations","with","a","valency","of","one","from","one","side","of","a","membrane","to","the","other",".","Inorganic","cations","are","atoms","or","small","molecules","with","a","positive","charge","that","do","not","contain","carbon","in","covalent","linkage","."),4178471). assertion_content_comment('tOboGo_MonovalentInorganicCationTransport',s("The","directed","movement","of","inorganic","cations","with","a","valency","of","one","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Inorganic","cations","are","atoms","or","small","molecules","with","a","positive","charge","which","do","not","contain","carbon","in","covalent","linkage","."),3991117). assertion_content_comment('tOboGo_MorphineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","morphine",",","17-methyl-7",",","8-didehydro-4",",","5alpha-epoxymorphinan-3",",","6alpha-diol",".","Morphine","is","a","highly","potent","opiate","analgesic","psychoactive","drug","obtained","form","the","opium","poppy",",","Papaver","somniferum","."),4166700). assertion_content_comment('tOboGo_MorphineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","morphine",",","17-methyl-7",",","8-didehydro-4",",","5alpha-epoxymorphinan-3",",","6alpha-diol",".","Morphine","is","a","highly","potent","opiate","analgesic","psychoactive","drug","obtained","form","the","opium","poppy",",","Papaver","somniferum","."),4166696). assertion_content_comment('tOboGo_MorphogenActivity',s("Acts","as","a","trigger","for","a","pattern","specification","process","when","present","at","a","specific","concentration","within","a","gradient","."),4302766). assertion_content_comment('tOboGo_MorphogenesisOfABranchingEpithelium',s("The","process","in","which","the","anatomical","structures","of","a","branched","epithelium","are","generated","and","organized","."),3980791). assertion_content_comment('tOboGo_MorphogenesisOfABranchingStructure',s("The","process","in","which","the","anatomical","structures","of","branches","are","generated","and","organized",".","A","branch","is","a","division","or","offshoot","from","a","main","stem",".","Examples","in","animals","would","include","blood","vessels",",","nerves",",","lymphatics","and","other","endothelial","or","epithelial","tubes","."),3980715). assertion_content_comment('tOboGo_MorphogenesisOfAnEndothelium',s("The","process","in","which","the","anatomical","structure","of","an","endothelium","is","generated","and","organized",".","An","endothelium","is","an","epithelium","that","lines","an","anatomical","structure","."),4003578). assertion_content_comment('tOboGo_MorphogenesisOfAnEpithelialBud',s("The","morphogenetic","process","in","which","a","bud","forms","from","an","epithelial","sheet",".","A","bud","is","a","protrusion","that","forms","form","the","sheet","by","localized","folding","."),4111915). assertion_content_comment('tOboGo_MorphogenesisOfAnEpithelialFoldInvolvedInEmbryonicHeartTubeFormation',s("The","morphogenetic","process","in","which","an","epithelial","sheet","bends","along","a","linear","axis",",","contributing","to","embryonic","heart","tube","formation","."),4003683). assertion_content_comment('tOboGo_MorphogenesisOfAnEpithelialFold',s("The","morphogenetic","process","in","which","an","epithelial","sheet","bends","along","a","linear","axis","."),3987183). assertion_content_comment('tOboGo_MorphogenesisOfAnEpithelialSheet',s("The","process","in","which","the","anatomical","structures","of","an","epithelial","sheet","are","generated","and","organized",".","An","epithelial","sheet","is","a","flat","surface","consisting","of","closely","packed","epithelial","cells","."),4005955). assertion_content_comment('tOboGo_MorphogenesisOfAnEpithelium',s("The","process","in","which","the","anatomical","structures","of","epithelia","are","generated","and","organized",".","An","epithelium","consists","of","closely","packed","cells","arranged","in","one","or","more","layers",",","that","covers","the","outer","surfaces","of","the","body","or","lines","any","internal","cavity","or","tube","."),3980789). assertion_content_comment('tOboGo_MorphogenesisOfAPolarizedEpithelium',s("The","morphogenetic","process","in","which","the","anatomical","structures","of","a","polarized","epithelium","are","generated","and","organized",".","A","polarized","epithelium","is","an","epithelium","where","the","epithelial","sheet","is","oriented","with","respect","to","the","planar","axis","."),3982309). assertion_content_comment('tOboGo_MorphogenesisOfEmbryonicEpithelium',s("The","process","in","which","the","anatomical","structures","of","embryonic","epithelia","are","generated","and","organized","."),3987035). assertion_content_comment('tOboGo_MorphogenesisOfFollicularEpithelium',s("The","process","in","which","the","anatomical","structures","of","a","follicular","epithelium","are","generated","and","organized","."),4014830). assertion_content_comment('tOboGo_MorphogenesisOfLarvalImaginalDiscEpithelium',s("The","process","in","which","the","anatomical","structures","of","a","larval","imaginal","disc","epithelium","are","generated","and","organized","."),4034540). assertion_content_comment('tOboGo_MotileCilium',s("A","cilium","which","has","a","variable","arrangement","of","axonemal","microtubules",",","contains","molecular","motors",",","and","beats","with","a","characteristic","whip-like","pattern","that","promotes","cell","motility","or","transport","of","fluids","and","other","cells","across","a","cell","surface",".","Motile","cilia","are","typically","found","in","multiple","copies","on","epithelial","cells","that","line","the","lumenal","ducts","of","various","tissues",".","Motile","cilia","may","also","function","as","sensory","organelles","."),4321829). assertion_content_comment('tOboGo_MotilePrimaryCilium',s("A","primary","cilium","which","may","contain","a","variable","array","of","axonemal","microtubules","and","also","contains","molecular","motors",".","Motile","primary","cilia","display","a","distinct","twirling","motion","that","directs","fluid","flow","asymmetrically","across","the","cellular","surface","to","affect","asymmetric","body","plan","organization","."),4321841). assertion_content_comment('tOboGo_MotilinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","motilin","receptor","."),4323519). assertion_content_comment('tOboGo_MotogenicSignalingInitiatingCellMovementInCerebralCortex',s("The","interaction","of","soluble","factors","and","receptors","that","result","in","the","movement","of","cells","in","the","primitive","cerebral","cortex","."),4049951). assertion_content_comment('tOboGo_MotogenicSignalingInvolvedInInterneuronMigrationFromTheSubpalliumToTheCortex',s("The","creation","and","reception","of","signals","that","result","in","the","directional","movement","of","interneuron","precursors","from","the","subpallium","to","the","cortex","."),4051154). assertion_content_comment('tOboGo_MotogenicSignalingInvolvedInPostnatalOlfactoryBulbInterneuronMigration',s("The","signaling","that","results","in","the","stimulation","of","cell","movement","in","the","rostral","migratory","stream","."),4051179). assertion_content_comment('tOboGo_MotorActivity',s("Catalysis","of","movement","along","a","polymeric","molecule","such","as","a","microfilament","or","microtubule",",","coupled","to","the","hydrolysis","of","a","nucleoside","triphosphate","."),4159563). assertion_content_comment('tOboGo_MotorAxonGuidance',s("The","process","in","which","the","migration","of","an","axon","growth","cone","of","a","motor","neuron","is","directed","to","a","specific","target","site","in","response","to","a","combination","of","attractive","and","repulsive","cues","."),4049380). assertion_content_comment('tOboGo_MotorNeuronPrecursorMigrationInvolvedInDorsalMotorNucleusOfVagusNerveFormation',s("The","orderly","movement","of","a","motor","neuron","precursor","cell","that","contributes","to","formation","of","the","dorsal","motor","nucleus","of","the","vagus","nerve","."),4081493). assertion_content_comment('tOboGo_MovementInEnvironmentOfOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","an","organism","or","motile","cell","on",",","within","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4045519). assertion_content_comment('tOboGo_MovementInHostEnvironment',s("The","directed","movement","of","an","organism","or","motile","cell","on",",","within","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4045540). assertion_content_comment('tOboGo_MovementInHost',s("The","process","in","which","an","organism","or","its","progeny","spreads","from","one","location","to","another","within","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4136554). assertion_content_comment('tOboGo_MovementInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","or","its","progeny","spreads","from","one","location","to","another","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4136549). assertion_content_comment('tOboGo_MovementInSymbiontEnvironment',s("The","directed","movement","of","an","organism","or","motile","cell","on",",","within","or","near","its","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197174). assertion_content_comment('tOboGo_MovementOfGroupIIntron',s("Lateral","transfer","of","a","group","I","intron","to","a","homologous","allele","that","lacks","the","intron",",","mediated","by","a","site-specific","endonuclease","encoded","within","the","mobile","intron",";","group","I","introns","are","self-splicing","introns","that","use","guanosine","as","a","cofactor","in","the","splicing","reaction","."),4222382). assertion_content_comment('tOboGo_MovementOnOrNearHost',s("The","directed","movement","of","an","organism","or","motile","cell","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146451). assertion_content_comment('tOboGo_MovementOnOrNearOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","an","organism","or","motile","cell","on","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4146448). assertion_content_comment('tOboGo_MovementOnOrNearSymbiont',s("The","directed","movement","of","an","organism","or","motile","cell","on","or","near","its","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197177). assertion_content_comment('tOboGo_MOZMORFHistoneAcetyltransferaseComplex',s("A","histone","acetyltransferase","complex","that","has","histone","H3","acetyltransferase","and","coactivator","activities",".","Subunits","of","the","human","complex","include","MYST3/MOZ",",","MYST4/MORF",",","ING5",",","EAF6","and","one","of","BRPF1",",","BRD1/BRPF2","and","BRPF3","."),4176416). assertion_content_comment('tOboGo_MPFComplex',s("A","complex","consisting","of","a","Cdc2-class","(","also","known","as","Cdc28",")","cyclin-dependent","kinase","and","an","M-phase","cyclin","such","as","S",".","pombe","Cdc13",".","The","MPF","complex","phosphorylates","and","activates","the","anaphase","promoting","complex","(","APC",")"),4319831). assertion_content_comment('tOboGo_MPhaseOfMeioticCellCycle',s("M","phase","occurring","as","part","of","the","meiotic","cell","cycle",".","M","phase","is","the","part","of","the","cell","cycle","during","which","nuclear","division","takes","place",".","A","meiotic","cell","cycle","is","one","in","which","canonically","a","cell","replicates","to","produce","four","offspring","with","half","the","chromosomal","content","of","the","progenitor","cell","."),3973656). assertion_content_comment('tOboGo_MPhaseOfMitoticCellCycle',s("M","phase","occurring","as","part","of","the","mitotic","cell","cycle",".","M","phase","is","the","part","of","the","cell","cycle","during","which","nuclear","division","takes","place",".","A","mitotic","cell","cycle","is","one","which","canonically","comprises","four","successive","phases","called","G1",",","S",",","G2",",","and","M","and","includes","replication","of","the","genome","and","the","subsequent","segregation","of","chromosomes","into","daughter","cells","."),3970444). assertion_content_comment('tOboGo_MPhase',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","M","phase",",","the","part","of","the","cell","cycle","comprising","nuclear","division","."),3969310). assertion_content_comment('tOboGo_MPhaseSpecificMicrotubuleProcess',s("A","microtubule-based","process","that","occurs","only","during","M","phase","of","the","cell","cycle","."),3970556). assertion_content_comment('tOboGo_Mpp10Complex',s("A","protein","complex","that","forms","a","subcomplex","of","the","90S","preribosome",".","In","S",".","cerevisiae",",","it","is","composed","of","Mpp10p",",","Imp3p","and","Imp4p","."),4074962). assertion_content_comment('tOboGo_Mre11Complex',s("Trimeric","protein","complex","that","possesses","endonuclease","activity",";","involved","in","meiotic","recombination",",","DNA","repair","and","checkpoint","signaling",".","In","Saccharomyces","cerevisiae",",","the","complex","comprises","Mre11p",",","Rad50p",",","and","Xrs2p",";","complexes","identified","in","other","species","generally","contain","proteins","orthologous","to","the","Saccharomyces","cerevisiae","proteins","."),4307024). assertion_content_comment('tOboGo_Mrf4Binding',s("Interacting","selectively","and","non-covalently","with","the","muscle","regulatory","factor","Mrf4","."),4284067). assertion_content_comment('tOboGo_MRFBinding',s("Interacting","selectively","and","non-covalently","with","Myogenic","Regulatory","Factor","(","MRF",")",",","a","member","of","the","basic","Helix-Loop-Helix","(","bHLH",")","superfamily","of","transcription","factors","."),4284065). assertion_content_comment('tOboGo_MRNABinding',s("Interacting","selectively","and","non-covalently","with","pre-messenger","RNA","(","pre-mRNA",")","or","messenger","RNA","(","mRNA",")"),4165413). assertion_content_comment('tOboGo_MRNACapBindingComplex',s("Any","protein","complex","that","binds","to","an","mRNA","cap","at","any","time","in","the","lifetime","of","the","mRNA","."),4221720). assertion_content_comment('tOboGo_MRNACapBinding',s("OBSOLETE",".","Interacting","selectively","with","the","7-methylguanosine","cap","at","the","5","'","end","of","a","nascent","messenger","RNA","transcript","."),4192648). assertion_content_comment('tOboGo_MRNACapMethyltransferaseComplex',s("A","protein","complex","that","consists","of","an","RNA","5","'","triphosphatase","and","a","guanyl","transferase","(","Cet1p","and","Ceg1p","in","S",".","cerevisiae",";","Pct1","and","Ceg1","in","S",".","pombe",")","and","is","involved","in","mRNA","capping","."),4321980). assertion_content_comment('tOboGo_MRNACapping',s("Addition","of","the","7-methylguanosine","cap","to","the","5","'","end","of","a","nascent","messenger","RNA","transcript","."),4224179). assertion_content_comment('tOboGo_MRNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","mRNA",",","messenger","RNA",",","which","is","responsible","for","carrying","the","coded","genetic","'","message","'",",","transcribed","from","DNA",",","to","sites","of","protein","assembly","at","the","ribosomes","."),3974285). assertion_content_comment('tOboGo_MRNACleavageAndPolyadenylationSpecificityFactorComplex',s("A","multisubunit","complex","that","binds","to","the","canonical","AAUAAA","hexamer","and","to","U-rich","upstream","sequence","elements","on","the","pre-mRNA",",","thereby","stimulating","the","otherwise","weakly","active","and","nonspecific","polymerase","to","elongate","efficiently","RNAs","containing","a","poly","(","A",")","signal","."),4221706). assertion_content_comment('tOboGo_MRNACleavageFactorComplex',s("Any","macromolecular","complex","involved","in","cleavage","or","polyadenylation","of","mRNA","molecules","."),4221591). assertion_content_comment('tOboGo_MRNACleavageInvolvedInGeneSilencingByMiRNA',s("The","process","in","which","microRNAs","(","miRNAs",")","direct","the","cleavage","of","target","mRNAs",".","Once","incorporated","into","a","RNA-induced","silencing","complex","(","RISC",")",",","a","miRNA","will","typically","direct","cleavage","by","base","pairing","with","near-perfect","complementarity","to","the","target","mRNA",".","Many","plant","miRNAs","downregulate","gene","expression","through","this","mechanism","."),4071008). assertion_content_comment('tOboGo_MRNACleavage',s("Any","process","in","which","a","pre-mRNA","or","mRNA","molecule","is","cleaved","at","specific","sites","or","in","a","regulated","manner","."),4058237). assertion_content_comment('tOboGo_MRNACleavageStimulatingFactorComplex',s("A","protein","complex","required","for","mRNA","cleavage","but","not","for","poly","(","A",")","addition","."),4221600). assertion_content_comment('tOboGo_MRNADestabilization',s("Any","process","that","decreases","the","stability","of","an","mRNA","molecule",",","making","it","more","vulnerable","to","degradative","processes",".","Messenger","RNA","is","the","intermediate","molecule","between","DNA","and","protein",".","It","includes","UTR","and","coding","sequences",".","It","does","not","contain","introns","."),4156253). assertion_content_comment('tOboGo_MRNAEditingComplex',s("A","protein","complex","that","posttranscriptionally","catalyzes","insertion",",","deletion","or","substitution","of","nucleotides","at","multiple","sites","within","nascent","mRNA","transcripts","to","produce","mature","mRNAs","in","eukaryotes","."),4298707). assertion_content_comment('tOboGo_MRNAExportFromNucleusInResponseToHeatStress',s("The","directed","movement","of","mRNA","from","the","nucleus","to","the","cytoplasm","during","a","heat","stimulus",",","a","temperature","stimulus","above","the","optimal","temperature","for","the","organism",";","in","particular",",","a","process","that","enables","an","organism","withstand","exposure","to","temperatures","that","would","otherwise","lethally","impair","poly","(","A",")","+","mRNA-nucleus","export","."),4320627). assertion_content_comment('tOboGo_MRNAExportFromNucleus',s("The","directed","movement","of","mRNA","from","the","nucleus","to","the","cytoplasm","."),4025533). assertion_content_comment('tOboGo_MRNAGuanylyltransferaseActivity',s("Catalysis","of","the","reaction",":","GTP","+","(","5","'",")","pp-Pur-mRNA","=","diphosphate","+","G","(","5","'",")","ppp-Pur-mRNA",";","G","(","5","'",")","ppp-Pur-mRNA","is","mRNA","containing","a","guanosine","residue","linked","5","'","through","three","phosphates","to","the","5","'","position","of","the","terminal","residue","."),4206117). assertion_content_comment('tOboGo_MRNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mRNA",",","messenger","RNA",",","which","is","responsible","for","carrying","the","coded","genetic","'","message","'",",","transcribed","from","DNA",",","to","sites","of","protein","assembly","at","the","ribosomes","."),3973559). assertion_content_comment('tOboGo_MRNAMethylation',s("The","posttranscriptional","addition","of","methyl","groups","to","specific","residues","in","an","mRNA","molecule","."),4182926). assertion_content_comment('tOboGo_MRNAMethyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosyl-L-methionine","to","a","nucleoside","residue","in","an","mRNA","molecule","."),4206142). assertion_content_comment('tOboGo_MRNAModification',s("The","covalent","alteration","of","one","or","more","nucleotides","within","an","mRNA","molecule","to","produce","an","mRNA","molecule","with","a","sequence","that","differs","from","that","coded","genetically","."),4150951). assertion_content_comment('tOboGo_MRNAPolyadenylation',s("The","enzymatic","addition","of","a","sequence","of","40-200","adenylyl","residues","at","the","3","'","end","of","a","eukaryotic","mRNA","primary","transcript","."),4224302). assertion_content_comment('tOboGo_MRNAProcessing',s("Any","process","involved","in","the","conversion","of","a","primary","mRNA","transcript","into","one","or","more","mature","mRNA","(","s",")","prior","to","translation","into","polypeptide","."),3973562). assertion_content_comment('tOboGo_MRNASpliceSiteSelection',s("Selection","of","a","splice","site","by","components","of","the","assembling","spliceosome","."),3975979). assertion_content_comment('tOboGo_MRNASplicing',s("OBSOLETE",".","The","process","in","which","excision","of","introns","from","the","primary","transcript","of","messenger","RNA","(","mRNA",")","is","followed","by","ligation","of","the","two","exon","termini","exposed","by","removal","of","each","intron",",","so","that","mRNA","consisting","only","of","the","joined","exons","is","produced","."),4224244). assertion_content_comment('tOboGo_MRNASplicingViaEndonucleolyticCleavageAndLigation',s("Splicing","of","mRNA","substrates","via","recognition","of","the","folded","RNA","structure","that","brings","the","5","'","and","3","'","splice","sites","into","proximity","and","cleavage","of","the","RNA","at","both","the","3","'","and","5","'","splice","sites","by","an","endonucleolytic","mechanism",",","followed","by","ligation","of","the","exons","."),4133826). assertion_content_comment('tOboGo_MRNAStabilization',s("Prevention","of","degradation","of","mRNA","molecules",".","In","the","absence","of","compensating","changes","in","other","processes",",","the","slowing","of","mRNA","degradation","can","result","in","an","overall","increase","in","the","population","of","active","mRNA","molecules","."),4177945). assertion_content_comment('tOboGo_MRNATranscriptionFromRNAPolymeraseIIPromoter',s("The","cellular","synthesis","of","messenger","RNA","(","mRNA",")","from","a","DNA","template","by","RNA","Polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter","."),4316982). assertion_content_comment('tOboGo_MRNATranscription',s("The","cellular","synthesis","of","messenger","RNA","(","mRNA",")","from","a","DNA","template","."),4236730). assertion_content_comment('tOboGo_MRNATransport',s("The","directed","movement","of","mRNA",",","messenger","ribonucleic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4025531). assertion_content_comment('tOboGo_MSLComplex',s("A","histone","acetyltransferase","complex","that","catalyzes","the","acetylation","of","a","histone","H4","lysine","residue","at","position","16",".","In","human",",","it","contains","the","catalytic","subunit","MOF",",","and","MSL1",",","MSL2","and","MSL3","."),4156551). assertion_content_comment('tOboGo_MucilageBiosyntheticProcessInvolvedInSeedCoatDevelopment',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mucilage","that","occur","as","part","of","seed","coat","development",";","mucilage","is","normally","synthesized","during","seed","coat","development","."),4334548). assertion_content_comment('tOboGo_MucilageBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mucilage",",","a","gelatinous","substance","secreted","by","plants","."),4102493). assertion_content_comment('tOboGo_MucilageExtrusionFromSeedCoat',s("The","process","in","which","seed","mucilage","expands","through","hydration","and","breaks","the","outer","cell","wall","that","encapsulates","the","whole","seed","upon","imbibition",".","Mucilage",",","mainly","composed","of","pectins",",","is","formed","during","seed","development","and","deposited","into","the","apoplast","underneath","the","outer","wall","of","the","seed","coat","."),4148851). assertion_content_comment('tOboGo_MucilageMetabolicProcessInvolvedSeedCoatDevelopment',s("The","chemical","reactions","and","pathways","involving","mucilage","that","occur","as","part","of","seed","coat","development",";","mucilage","is","normally","synthesized","during","seed","coat","development","."),4102481). assertion_content_comment('tOboGo_MucilageMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mucilage",",","a","gelatinous","substance","secreted","by","plants","."),4102447). assertion_content_comment('tOboGo_MucilagePectinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","pectin","component","of","mucilage","."),4102523). assertion_content_comment('tOboGo_MucilagePectinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","pectin","component","of","mucilage","."),4102469). assertion_content_comment('tOboGo_MucinaminylserineMucinaminidaseActivity',s("Catalysis","of","the","reaction",":","D-galactosyl-3-","(","N-acetyl-beta-D-galactosaminyl",")","-L-serine","+","H2O","=","D-galactosyl-3-N-acetyl-beta-D-galactosamine","+","L-serine","."),4271923). assertion_content_comment('tOboGo_MuconateCycloisomeraseActivity',s("Catalysis","of","the","reaction",":","2",",","5-dihydro-5-oxofuran-2-acetate","=","cis",",","cis-hexadienedioate","."),4273879). assertion_content_comment('tOboGo_MucosalImmuneResponse',s("An","immune","response","taking","place","in","mucosal","tissues",",","including","those","of","the","intestinal","tract",",","nasal","and","upper","respiratory","tract",",","and","genital","tract","."),3993408). assertion_content_comment('tOboGo_MucosalLymphocyteHomeostasis',s("The","process","of","regulating","the","proliferation","and","elimination","of","lymphocytes","such","that","the","total","number","of","lymphocytes","within","the","mucosal","tissue","of","an","organism","is","stable","over","time","in","the","absence","of","an","outside","stimulus","."),4378011). assertion_content_comment('tOboGo_MucosalToleranceInduction',s("Tolerance","induction","taking","place","in","the","mucosal","tissues","."),4379368). assertion_content_comment('tOboGo_MucusLayer',s("An","extracellular","region","part","that","consists","of","a","protective","layer","of","mucus","secreted","by","epithelial","cells","lining","tubular","organs","of","the","body","such","as","the","colon",".","Mucus","is","a","viscous","slimy","secretion","consisting","of","mucins","and","various","inorganic","salts","dissolved","in","water",",","with","suspended","epithelial","cells","and","leukocytes","."),4176525). assertion_content_comment('tOboGo_MucusSecretion',s("The","regulated","release","of","mucus","by","the","mucosa",".","Mucus","is","a","viscous","slimy","secretion","consisting","of","mucins","and","various","inorganic","salts","dissolved","in","water",",","with","suspended","epithelial","cells","and","leukocytes",".","The","mucosa",",","or","mucous","membrane",",","is","the","membrane","covered","with","epithelium","that","lines","the","tubular","organs","of","the","body",".","Mucins","are","carbohydrate-rich","glycoproteins","that","have","a","lubricating","and","protective","function","."),4137147). assertion_content_comment('tOboGo_MullerianDuctRegression',s("The","process","in","which","the","Mullerian","ducts",",","primordia","of","the","oviducts",",","uterus","and","upper","vagina",",","undergo","regression","in","male","embryos","."),3986525). assertion_content_comment('tOboGo_MulticellularOrganismAdhesion',s("The","attachment","of","a","multicellular","organism","to","a","substrate","or","other","organism","."),4015304). assertion_content_comment('tOboGo_MulticellularOrganismAdhesionToSubstrate',s("The","attachment","of","a","multicellular","organism","to","a","surface","or","material","."),4015306). assertion_content_comment('tOboGo_MulticellularOrganismalAging',s("The","inherent","decline","of","a","multicellular","organism","over","time",",","from","the","optimal","fertility","and","viability","of","early","maturity",",","that","may","precede","death","and","may","be","preceded","by","other","indications",",","such","as","sterility","."),4020741). assertion_content_comment('tOboGo_MulticellularOrganismalBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","substances","in","multicellular","organisms",",","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),4288077). assertion_content_comment('tOboGo_MulticellularOrganismalCarbohydrateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y",",","in","multicellular","organisms","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),4097946). assertion_content_comment('tOboGo_MulticellularOrganismalCarbohydrateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y",",","in","multicellular","organisms",",","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),4097927). assertion_content_comment('tOboGo_MulticellularOrganismalCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","substances","in","multicellular","organisms","that","occur","at","the","tissue",",","organ",",","or","organismal","level",".","These","processes",",","unlike","cellular","metabolism",",","can","include","transport","of","substances","between","cells","when","that","transport","is","required","."),3991706). assertion_content_comment('tOboGo_MulticellularOrganismalDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","multicellular","organism","over","time","from","an","initial","condition","(","e.g",".","a","zygote","or","a","young","adult",")","to","a","later","condition","(","e.g",".","a","multicellular","animal","or","an","aged","adult",")"),3978757). assertion_content_comment('tOboGo_MulticellularOrganismalHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","at","the","level","of","the","multicellular","organism","."),3985546). assertion_content_comment('tOboGo_MulticellularOrganismalIronIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","the","distribution","of","iron","stores","within","tissues","and","organs","of","a","multicellular","organism","."),4160816). assertion_content_comment('tOboGo_MulticellularOrganismalLipidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lipids",",","occurring","at","the","tissue",",","organ",",","or","organismal","level","of","a","multicellular","organism","."),4098013). assertion_content_comment('tOboGo_MulticellularOrganismalLocomotion',s("Locomotion","in","a","multicellular","organism",",","i.e",".","self-propelled","movement","of","a","multicellular","organism","from","one","location","to","another","."),4168422). assertion_content_comment('tOboGo_MulticellularOrganismalMacromoleculeCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","macromolecule",",","any","large","molecule","including","proteins",",","nucleic","acids","and","carbohydrates",",","in","multicellular","organisms","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),3991719). assertion_content_comment('tOboGo_MulticellularOrganismalMacromoleculeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","macromolecules",",","large","molecules","including","proteins",",","nucleic","acids","and","carbohydrates",",","in","multicellular","organisms","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),3991741). assertion_content_comment('tOboGo_MulticellularOrganismalMetabolicProcess',s("The","chemical","reactions","and","pathways","in","multicellular","organisms","that","occur","at","the","tissue",",","organ",",","or","organismal","level",".","These","processes",",","unlike","cellular","metabolism",",","can","include","transport","of","substances","between","cells","when","that","transport","is","required","."),3991041). assertion_content_comment('tOboGo_MulticellularOrganismalMovement',s("Any","physiological","process","involved","in","changing","the","position","of","a","multicellular","organism","or","an","anatomical","part","of","a","multicellular","organism","."),3998931). assertion_content_comment('tOboGo_MulticellularOrganismalOligosaccharideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","oligosaccharides",",","molecules","with","between","two","and","(","about",")","20","monosaccharide","residues","connected","by","glycosidic","linkages",",","in","multicellular","organisms",",","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),4285315). assertion_content_comment('tOboGo_MulticellularOrganismalOligosaccharideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","oligosaccharides",",","molecules","with","between","two","and","(","about",")","20","monosaccharide","residues","connected","by","glycosidic","linkages",",","in","multicellular","organisms",",","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),4285312). assertion_content_comment('tOboGo_MulticellularOrganismalPolysaccharideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","polysaccharides",",","occurring","at","the","tissue",",","organ",",","or","organismal","level","of","a","multicellular","organism","."),4097952). assertion_content_comment('tOboGo_MulticellularOrganismalPolysaccharideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","polysaccharides",",","polymers","of","more","than","10","monosaccharide","residues","joined","by","glycosidic","linkages",",","in","multicellular","organisms","that","occur","at","the","tissue",",","organ",",","or","organismal","level","."),4097930). assertion_content_comment('tOboGo_MulticellularOrganismalProcess',s("Any","biological","process",",","occurring","at","the","level","of","a","multicellular","organism",",","pertinent","to","its","function","."),3973412). assertion_content_comment('tOboGo_MulticellularOrganismalProteinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","in","a","multicellular","organism",",","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),3991767). assertion_content_comment('tOboGo_MulticellularOrganismalProteinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","specific","protein",",","rather","than","of","proteins","in","general",",","in","multicellular","organisms","occurring","at","the","tissue",",","organ",",","or","organismal","level","."),3991744). assertion_content_comment('tOboGo_MulticellularOrganismalReproductiveBehavior',s("The","specific","actions","or","reactions","of","an","organism","that","are","associated","with","reproduction","in","a","multicellular","organism","."),4014943). assertion_content_comment('tOboGo_MulticellularOrganismalReproductiveProcess',s("The","process",",","occurring","above","the","cellular","level",",","that","is","pertinent","to","the","reproductive","function","of","a","multicellular","organism",".","This","includes","the","integrated","processes","at","the","level","of","tissues","and","organs","."),3980947). assertion_content_comment('tOboGo_MulticellularOrganismalResponseToStress',s("A","change","in","state","or","activity","of","a","multicellular","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","stimulus","indicating","the","organism","is","under","stress",".","The","stress","is","usually",",","but","not","necessarily",",","exogenous","(","e.g",".","temperature",",","humidity",",","ionizing","radiation",")"),4122548). assertion_content_comment('tOboGo_MulticellularOrganismalSignaling',s("The","transfer","of","information","occurring","at","the","level","of","a","multicellular","organism","."),3981604). assertion_content_comment('tOboGo_MulticellularOrganismalWaterHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","water","within","a","tissue",",","organ",",","or","a","multicellular","organism","."),4004085). assertion_content_comment('tOboGo_MulticellularOrganismGrowth',s("The","increase","in","size","or","mass","of","an","entire","multicellular","organism",",","as","opposed","to","cell","growth","."),3990939). assertion_content_comment('tOboGo_MulticellularOrganismReproduction',s("The","biological","process","in","which","new","individuals","are","produced","by","one","or","two","multicellular","organisms",".","The","new","individuals","inherit","some","proportion","of","their","genetic","material","from","the","parent","or","parents","."),3980945). assertion_content_comment('tOboGo_MulticellularPellicleFormation',s("A","process","in","which","microorganisms","produce","an","extracellular","matrix","and","form","multicellular","aggregates","at","an","air-liquid","interface","."),4330684). assertion_content_comment('tOboGo_MulticellularStructureSeptumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","multicellular","structure","septum","over","time",",","from","its","formation","to","the","mature","structure",".","The","multicellular","structure","septum","is","the","thin","partition","or","membrane","that","divides","a","cavity","or","a","mass","of","tissue","."),4147502). assertion_content_comment('tOboGo_MulticopperFerroxidaseIronTransportMediatorActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","4","Fe2","+","+","4","H","+","+","O2","=","4","Fe3","+","+","2","H2O","."),4208589). assertion_content_comment('tOboGo_MultidimensionalCellGrowth',s("The","process","in","which","a","cell","irreversibly","increases","in","size","in","two","or","three","[","spatial","]","dimensions","or","along","two","or","three","axes","."),4077448). assertion_content_comment('tOboGo_MultimericRibonucleasePComplex',s("A","ribonuclease","P","complex","that","generally","contains","a","single","RNA","molecule","and","several","protein","molecules",".","Examples","of","this","complex","are","found","in","Archaeal","species","."),4051574). assertion_content_comment('tOboGo_MultinuclearOsteoclastDifferentiation',s("The","process","in","which","a","relatively","unspecialized","monocyte","acquires","the","specialized","features","of","a","multinuclear","osteoclast",".","An","osteoclast","is","a","specialized","phagocytic","cell","associated","with","the","absorption","and","removal","of","the","mineralized","matrix","of","bone","tissue","."),4146702). assertion_content_comment('tOboGo_MultipartiteViralGenome',s("A","segmented","viral","genome","consisting","of","more","than","three","sub-genomic","nucleic","acids","but","each","nucleic","acid","is","packaged","into","a","different","virion","."),4236384). assertion_content_comment('tOboGo_MultivesicularBodyMembraneDisassembly',s("The","controlled","breakdown","of","the","membranes","of","multivesicular","bodies","."),4357450). assertion_content_comment('tOboGo_MultivesicularBodyMembrane',s("The","lipid","bilayer","surrounding","a","multivesicular","body","."),4067556). assertion_content_comment('tOboGo_MultivesicularBody',s("A","type","of","late","endosome","in","which","regions","of","the","limiting","endosomal","membrane","invaginate","to","form","internal","vesicles",";","membrane","proteins","that","enter","the","internal","vesicles","are","sequestered","from","the","cytoplasm","."),4067543). assertion_content_comment('tOboGo_MultivesicularBodySortingPathway',s("A","vesicle-mediated","transport","process","in","which","transmembrane","proteins","are","ubiquitylated","to","facilitate","their","entry","into","luminal","vesicles","of","multivesicular","bodies","(","MVBs",")",";","upon","subsequent","fusion","of","MVBs","with","lysosomes","or","vacuoles",",","the","cargo","proteins","are","degraded","."),4168831). assertion_content_comment('tOboGo_MuramylDipeptideBinding',s("Interacting","selectively","and","non-covalently",",","in","a","non-covalent","manner",",","with","muramyl","dipeptide",";","muramyl","dipeptide","is","derived","from","peptidoglycan","."),4335309). assertion_content_comment('tOboGo_MureinSacculus',s("OBSOLETE",".","A","peptidoglycan","polymer","that","forms","the","shape-determining","structure","of","the","cell","all","of","Gram-negative","bacteria","."),4257268). assertion_content_comment('tOboGo_MuscarinicAcetylcholineReceptorActivity',s("Combining","with","acetylcholine","to","initiate","a","change","in","cell","activity","via","activation","of","a","G","protein",",","with","pharmacological","characteristics","of","muscarinic","receptors","."),4198867). assertion_content_comment('tOboGo_MuscarinicAcetylcholineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","muscarinic","acetylcholine","receptor","."),4323529). assertion_content_comment('tOboGo_MuscarinicAcetylcholineReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","muscarinic","acetylcholine","receptor","binding","to","one","of","its","physiological","ligands",";","muscarinic","acetylcholine","receptors","activate","inhibitory","G","proteins","and","can","be","activated","by","the","fungal","alkaloid","muscarine","."),4235628). assertion_content_comment('tOboGo_MuscleAdaptation',s("A","process","in","which","muscle","adapts",",","with","consequent","modifications","to","structural","and/or","functional","phenotypes",",","in","response","to","a","stimulus",".","Stimuli","include","contractile","activity",",","loading","conditions",",","substrate","supply",",","and","environmental","factors",".","These","adaptive","events","occur","in","both","muscle","fibers","and","associated","structures","(","motoneurons","and","capillaries",")",",","and","they","involve","alterations","in","regulatory","mechanisms",",","contractile","properties","and","metabolic","capacities","."),4028265). assertion_content_comment('tOboGo_MuscleAtrophy',s("A","process",",","occurring","in","the","muscle",",","that","is","characterized","by","a","decrease","in","protein","content",",","fiber","diameter",",","force","production","and","fatigue","resistance","in","response","to","different","conditions","such","as","starvation",",","aging","and","disuse","."),4040356). assertion_content_comment('tOboGo_MuscleAttachment',s("The","developmental","process","in","which","a","skeletal","muscle","attaches","to","its","target","(","such","as","bone","or","body","wall",")"),4034164). assertion_content_comment('tOboGo_MuscleCellApoptosis',s("A","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","muscle","cell","and","result","in","its","death",".","A","muscle","cell","is","a","mature","contractile","cell",",","commonly","known","as","a","myocyte",",","that","forms","one","of","three","kinds","of","muscle","."),4026215). assertion_content_comment('tOboGo_MuscleCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","muscle","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Muscle","cell","development","does","not","include","the","steps","involved","in","committing","an","unspecified","cell","to","the","muscle","cell","fate","."),4002852). assertion_content_comment('tOboGo_MuscleCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","muscle","cell","."),4002850). assertion_content_comment('tOboGo_MuscleCellFateCommitment',s("The","process","in","which","the","cellular","identity","of","muscle","cells","is","acquired","and","determined","."),4018560). assertion_content_comment('tOboGo_MuscleCellFateDetermination',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","muscle","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4018570). assertion_content_comment('tOboGo_MuscleCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","muscle","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4078305). assertion_content_comment('tOboGo_MuscleCellHomeostasis',s("The","cellular","homeostatic","process","that","preserves","a","muscle","cell","in","a","stable","functional","or","structural","state","."),4356883). assertion_content_comment('tOboGo_MuscleCellMigration',s("The","orderly","movement","of","a","muscle","cell","from","one","site","to","another",",","often","during","the","development","of","a","multicellular","organism","."),4038450). assertion_content_comment('tOboGo_MuscleCellProliferation',s("The","expansion","of","a","muscle","cell","population","by","cell","division","."),4038651). assertion_content_comment('tOboGo_MuscleContraction',s("A","process","in","which","force","is","generated","within","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis","."),3998967). assertion_content_comment('tOboGo_MuscleFiberDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","muscle","fiber","over","time",",","from","its","formation","to","the","mature","structure",".","Muscle","fibers","are","formed","by","the","maturation","of","myotubes",".","They","can","be","classed","as","slow",",","intermediate/fast","or","fast","."),4018501). assertion_content_comment('tOboGo_MuscleFiber',s("OBSOLETE",".","The","contractile","fibers",",","composed","of","actin",",","myosin",",","and","associated","proteins",",","found","in","cells","of","smooth","or","striated","muscle","."),4310330). assertion_content_comment('tOboGo_MuscleFilamentSliding',s("The","sliding","of","actin","thin","filaments","and","myosin","thick","filaments","past","each","other","in","muscle","contraction",".","This","involves","a","process","of","interaction","of","myosin","located","on","a","thick","filament","with","actin","located","on","a","thin","filament",".","During","this","process","ATP","is","split","and","forces","are","generated","."),4038936). assertion_content_comment('tOboGo_MuscleHyperplasia',s("A","muscle","system","process","that","results","in","an","increase","in","cell","number","by","cell","division",",","often","leading","to","an","increase","in","the","size","of","an","organ","."),4039975). assertion_content_comment('tOboGo_MuscleHypertrophyInResponseToStress',s("The","enlargement","or","overgrowth","of","all","or","part","of","a","muscle","organ","or","tissue","due","to","an","increase","in","the","size","of","its","muscle","cells","as","a","result","of","a","disturbance","in","organismal","or","cellular","homeostasis","."),4194255). assertion_content_comment('tOboGo_MuscleHypertrophy',s("The","muscle","system","process","that","results","in","enlargement","or","overgrowth","of","all","or","part","of","a","muscle","organ","due","to","an","increase","in","the","size","of","its","muscle","cells",".","Physiological","hypertrophy","is","a","normal","process","during","development","(","it","stops","in","cardiac","muscle","after","adolescence",")","and","can","also","be","brought","on","in","response","to","demand",".","In","athletes","cardiac","and","skeletal","muscles","undergo","hypertrophy","stimulated","by","increasing","muscle","activity","on","exercise",".","Smooth","muscle","cells","in","the","uterus","undergo","hypertrophy","during","pregnancy","."),4001769). assertion_content_comment('tOboGo_MuscleMotorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193135). assertion_content_comment('tOboGo_MuscleMyosinComplex',s("A","filament","of","myosin","found","in","a","muscle","cell","of","any","type","."),4008548). assertion_content_comment('tOboGo_MuscleOrganDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","muscle","over","time",",","from","its","formation","to","the","mature","structure",".","The","muscle","is","an","organ","consisting","of","a","tissue","made","up","of","various","elongated","cells","that","are","specialized","to","contract","and","thus","to","produce","movement","and","mechanical","work","."),3990134). assertion_content_comment('tOboGo_MuscleOrganMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","muscle","are","generated","and","organized","."),4002790). assertion_content_comment('tOboGo_MuscleStructureDevelopment',s("The","progression","of","a","muscle","structure","over","time",",","from","its","formation","to","its","mature","state",".","Muscle","structures","are","contractile","cells",",","tissues","or","organs","that","are","found","in","multicellular","organisms","."),3990132). assertion_content_comment('tOboGo_MuscleSystemProcess',s("A","organ","system","process","carried","out","at","the","level","of","a","muscle",".","Muscle","tissue","is","composed","of","contractile","cells","or","fibers","."),3998964). assertion_content_comment('tOboGo_MuscleTendonJunction',s("A","cell-substrate","junction","found","at","the","terminal","anchorage","site","of","skeletal","muscle","cells","to","tendons","."),4220663). assertion_content_comment('tOboGo_MuscleThinFilamentAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","to","form","the","actin-based","thin","filaments","of","myofibrils","in","striated","muscle","."),4129057). assertion_content_comment('tOboGo_MuscleThinFilamentTropomyosin',s("A","form","of","the","tropomyosin","dimer","found","associated","with","actin","and","the","troponin","complex","in","muscle","thin","filaments","."),4008586). assertion_content_comment('tOboGo_MuscleTissueDevelopment',s("The","progression","of","muscle","tissue","over","time",",","from","its","initial","formation","to","its","mature","state",".","Muscle","tissue","is","a","contractile","tissue","made","up","of","actin","and","myosin","fibers","."),3990105). assertion_content_comment('tOboGo_MuscleTissueMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","muscle","tissue","are","generated","and","organized",".","Muscle","tissue","consists","of","a","set","of","cells","that","are","part","of","an","organ","and","carry","out","a","contractive","function","."),4002792). assertion_content_comment('tOboGo_MuscularSeptumMorphogenesis',s("The","process","in","which","the","muscular","septum","is","generated","and","organized",".","The","muscular","septum","is","the","lower","part","of","the","ventricular","septum","."),4003672). assertion_content_comment('tOboGo_MusculoskeletalMovementSpinalReflexAction',s("Involuntary","movement","caused","by","the","application","of","a","stimulus","to","an","organism","and","a","subsequent","movement",".","The","signal","processing","of","this","movement","takes","place","in","the","spinal","cord","."),4274092). assertion_content_comment('tOboGo_MusculoskeletalMovement',s("The","movement","of","an","organism","or","part","of","an","organism","using","mechanoreceptors",",","the","nervous","system",",","striated","muscle","and/or","the","skeletal","system","."),3998933). assertion_content_comment('tOboGo_MushroomBodyDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mushroom","body","over","time",",","from","its","formation","to","the","mature","structure",".","The","mushroom","body","is","composed","of","the","prominent","neuropil","structures","of","the","insect","central","brain",",","thought","to","be","crucial","for","olfactory","associated","learning",".","These","consist","mainly","of","a","bulbous","calyx","and","tightly","packaged","arrays","of","thin","parallel","fibers","of","the","Kenyon","cells","."),4034611). assertion_content_comment('tOboGo_Mutagenesis',s("OBSOLETE",".","The","process","by","which","genetic","material","undergoes","a","detectable","and","heritable","structural","change",".","There","are","three","categories","of","mutation",":","genome","mutations",",","involving","addition","or","subtraction","of","one","or","more","whole","chromosomes",";","chromosome","mutations",",","which","alter","the","structure","of","chromosomes",";","and","gene","mutations",",","where","the","structure","of","a","gene","is","altered","at","the","molecular","level","."),4223791). assertion_content_comment('tOboGo_MutLalphaComplexBinding',s("Interacting","selectively","and","non-covalently","with","the","mismatch","repair","complex","MutLalpha","."),4334975). assertion_content_comment('tOboGo_MutLalphaComplex',s("A","heterodimer","involved","in","the","recognition","of","base-base","and","small","insertion/deletion","mismatches",".","In","human","the","complex","consists","of","two","subunits",",","MLH1","and","PMS2","."),4333636). assertion_content_comment('tOboGo_MutLbetaComplexBinding',s("Interacting","selectively","and","non-covalently","with","the","mismatch","repair","complex","MutLbeta","."),4334938). assertion_content_comment('tOboGo_MutLbetaComplex',s("A","heterodimer","involved","in","the","recognition","of","base-base","and","small","insertion/deletion","mismatches",".","In","human","the","complex","consists","of","two","subunits",",","MLH1","and","PMS1","."),4333606). assertion_content_comment('tOboGo_MutSalphaComplexBinding',s("Interacting","selectively","and","non-covalently","with","the","mismatch","repair","complex","MutSalpha","."),4334947). assertion_content_comment('tOboGo_MutSalphaComplex',s("A","heterodimer","involved","in","the","recognition","and","repair","of","base-base","and","small","insertion/deletion","mismatches",".","In","human","the","complex","consists","of","two","subunits",",","MSH2","and","MSH6","."),4333967). assertion_content_comment('tOboGo_MutSbetaComplexBinding',s("Interacting","selectively","and","non-covalently","with","the","mismatch","repair","complex","MutSbeta","."),4334956). assertion_content_comment('tOboGo_MutSbetaComplex',s("A","heterodimer","involved","in","binding","to","and","correcting","insertion/deletion","mutations",".","In","human","the","complex","consists","of","two","subunits",",","MSH2","and","MSH3","."),4333944). assertion_content_comment('tOboGo_Mutualism',s("An","interaction","between","two","organisms","living","together","in","more","or","less","intimate","association","in","a","relationship","in","which","both","organisms","benefit","from","each","other","."),4083855). assertion_content_comment('tOboGo_MybComplex',s("A","multisubunit","complex","consisting","of","Myb","and","other","proteins","that","regulates","site","specific","DNA","replication",",","gene","amplification","and","transcriptional","repression","."),4321865). assertion_content_comment('tOboGo_MyceliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","mycelium","over","time",",","from","its","formation","to","the","mature","structure",".","A","mycelium","is","the","mass","of","hyphae","that","constitutes","the","vegetative","part","of","a","fungus","."),4094837). assertion_content_comment('tOboGo_MycocerosateSynthaseActivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","7n","H","(","+",")","+","n","methylmalonyl-CoA","+","2n","NADPH","=","n","CO","(","2",")","+","n","CoA","+","n","H","(","2",")","O","+","multi-methyl-branched","acyl-CoA","+","2n","NADP","(","+",")"),4271912). assertion_content_comment('tOboGo_MycodextranaseActivity',s("Catalysis","of","the","endohydrolysis","of","1",",","4-alpha-D-glucosidic","linkages","in","alpha-D-glucans","containing","both","1",",","3-","and","1",",","4-bonds","."),4344317). assertion_content_comment('tOboGo_MycolateCellWallLayerAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components",",","including","arabinogalactan","mycolate","and","trehalose","dimycolate",",","to","form","the","mycolate","layer","of","the","Actinobacterium-type","cell","wall",".","The","mycolate","layer","is","physically","attached","to","the","peptidoglycan","layer","."),4129390). assertion_content_comment('tOboGo_MycolicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mycolic","acids",",","beta-hydroxy","fatty","acids","with","a","long","alpha-alkyl","side","chain","."),4129375). assertion_content_comment('tOboGo_MycolicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mycolic","acids",",","beta-hydroxy","fatty","acids","with","a","long","alpha-alkyl","side","chain","."),4129370). assertion_content_comment('tOboGo_MycothiolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mycothiol",",","which","consists","of","N-acetyl-L-cysteine","linked","to","a","pseudodisaccharide",",","D-glucosamine","and","myo-inositol",".","Mycothiol","is","produced","in","actinomycetes","like","mycobacteria","and","serves","similar","functions","to","glutathione","."),4334461). assertion_content_comment('tOboGo_MycothiolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mycothiol",",","which","consists","of","N-acetyl-L-cysteine","linked","to","a","pseudodisaccharide",",","D-glucosamine","and","myo-inositol",".","Mycothiol","is","produced","in","actinomycetes","like","mycobacteria","and","serves","similar","functions","to","glutathione","."),4334447). assertion_content_comment('tOboGo_MycothiolSynthaseActivity',s("Catalysis","of","the","reaction",":","1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside","+","acetyl-CoA","=","mycothiol","+","coenzyme","A","+","H","+","Mycothiol","is","also","known","as","AcCys-GlcN-Ins","and","1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside","as","Cys-GlcN-Ins","or","desacetylmycothiol","."),4375668). assertion_content_comment('tOboGo_MycothioneReductaseActivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","+","+","mycothiol","=","NAD","(","P",")","H","+","H","+","+","mycothione","."),4277897). assertion_content_comment('tOboGo_MycotoxinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","mycotoxin",",","any","poisonous","substance","produced","by","a","fungus","."),4300162). assertion_content_comment('tOboGo_MycotoxinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","mycotoxin",",","any","poisonous","substance","produced","by","a","fungus","."),4318142). assertion_content_comment('tOboGo_MycotoxinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","mycotoxin",",","any","poisonous","substance","produced","by","a","fungus","."),4300159). assertion_content_comment('tOboGo_MyelinAssembly',s("The","process","in","which","the","wraps","of","cell","membrane","that","constitute","myelin","are","laid","down","around","an","axon","in","the","central","or","peripheral","nervous","system","."),4054565). assertion_content_comment('tOboGo_MyelinationInPeripheralNervousSystem',s("The","process","in","which","neuronal","axons","and","dendrites","become","coated","with","a","segmented","lipid-rich","sheath","(","myelin",")","to","enable","faster","and","more","energetically","efficient","conduction","of","electrical","impulses",".","The","sheath","is","formed","by","the","cell","membranes","of","Schwann","cells","in","the","peripheral","nervous","system",".","Adjacent","myelin","segments","are","separated","by","a","non-myelinated","stretch","of","axon","called","a","node","of","Ranvier","."),4053320). assertion_content_comment('tOboGo_MyelinationOfAnteriorLateralLineNerveAxons',s("The","formation","of","compact","myelin","sheaths","around","the","axons","of","the","anterior","lateral","line","nerve","."),4106188). assertion_content_comment('tOboGo_MyelinationOfLateralLineNerveAxons',s("The","formation","of","compact","myelin","sheaths","around","the","axons","of","a","lateral","line","nerve","."),4105936). assertion_content_comment('tOboGo_MyelinationOfPosteriorLateralLineNerveAxons',s("The","formation","of","compact","myelin","sheaths","around","the","axons","of","the","posterior","lateral","line","nerve","."),4106056). assertion_content_comment('tOboGo_Myelination',s("The","process","in","which","myelin","sheaths","are","formed","and","maintained","around","neurons",".","Oligodendrocytes","in","the","brain","and","spinal","cord","and","Schwann","cells","in","the","peripheral","nervous","system","wrap","axons","with","compact","layers","of","their","plasma","membrane",".","Adjacent","myelin","segments","are","separated","by","a","non-myelinated","stretch","of","axon","called","a","node","of","Ranvier","."),4053261). assertion_content_comment('tOboGo_MyelinMaintenance',s("The","process","of","preserving","the","structure","and","function","of","mature","myelin",".","This","includes","maintaining","the","compact","structure","of","myelin","necessary","for","its","electrical","insulating","characteristics","as","well","as","the","structure","of","non-compact","regions","such","as","Schmidt-Lantermann","clefts","and","paranodal","loops",".","This","does","not","include","processes","responsible","for","maintaining","the","nodes","of","Ranvier",",","which","are","not","part","of","the","myelin","sheath","."),4054506). assertion_content_comment('tOboGo_MyelinSheathAbaxonalRegion',s("The","region","of","the","myelin","sheath","furthest","from","the","axon","."),4082474). assertion_content_comment('tOboGo_MyelinSheathAdaxonalRegion',s("The","region","of","the","myelin","sheath","nearest","to","the","axon","."),4082464). assertion_content_comment('tOboGo_MyelinSheath',s("An","electrically","insulating","fatty","layer","that","surrounds","the","axons","of","many","neurons",".","It","is","an","outgrowth","of","glial","cells",":","Schwann","cells","supply","the","myelin","for","peripheral","neurons","while","oligodendrocytes","supply","it","to","those","of","the","central","nervous","system","."),4082453). assertion_content_comment('tOboGo_MyeloidCellActivationInvolvedInImmuneResponse',s("A","change","in","the","morphology","or","behavior","of","a","myeloid","cell","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),3996339). assertion_content_comment('tOboGo_MyeloidCellApoptosis',s("The","process","of","apoptosis","in","myeloid","cells","."),3984732). assertion_content_comment('tOboGo_MyeloidCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","myeloid","precursor","cell","acquires","the","specialized","features","of","any","cell","of","the","myeloid","leukocyte",",","megakaryocyte",",","thrombocyte",",","or","erythrocyte","lineages","."),3996684). assertion_content_comment('tOboGo_MyeloidCellHomeostasis',s("The","process","of","regulating","the","proliferation","and","elimination","of","myeloid","cells","such","that","the","total","number","of","myeloid","cells","within","a","whole","or","part","of","an","organism","is","stable","over","time","in","the","absence","of","an","outside","stimulus","."),3984714). assertion_content_comment('tOboGo_MyeloidDendriticCellActivationInvolvedInImmuneResponse',s("The","change","in","morphology","and","behavior","of","a","myeloid","dendritic","cell","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4377866). assertion_content_comment('tOboGo_MyeloidDendriticCellActivation',s("The","change","in","morphology","and","behavior","of","a","dendritic","cell","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),4061873). assertion_content_comment('tOboGo_MyeloidDendriticCellAntigenProcessingAndPresentation',s("The","process","in","which","a","myeloid","dendritic","cell","expresses","antigen","(","peptide","or","lipid",")","on","its","cell","surface","in","association","with","an","MHC","protein","complex","."),3994722). assertion_content_comment('tOboGo_MyeloidDendriticCellChemotaxis',s("The","movement","of","a","myeloid","dendritic","cell","in","response","to","an","external","stimulus","."),4144642). assertion_content_comment('tOboGo_MyeloidDendriticCellCytokineProduction',s("Any","process","that","contributes","to","cytokine","production","by","a","myeloid","dendritic","cell","."),3998745). assertion_content_comment('tOboGo_MyeloidDendriticCellDifferentiationInvolvedInImmuneResponse',s("The","process","in","which","an","immature","myeloid","dendritic","cell","acquires","the","specialized","features","of","a","mature","myeloid","dendritic","cell","as","part","of","an","immune","response","."),4378437). assertion_content_comment('tOboGo_MyeloidDendriticCellDifferentiation',s("The","process","in","which","a","monocyte","acquires","the","specialized","features","of","a","dendritic","cell",",","an","immunocompetent","cell","of","the","lymphoid","and","hemopoietic","systems","and","skin","."),4318069). assertion_content_comment('tOboGo_MyeloidLeukocyteActivation',s("A","change","in","the","morphology","or","behavior","of","a","myeloid","leukocyte","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand","."),3996335). assertion_content_comment('tOboGo_MyeloidLeukocyteCytokineProduction',s("Any","process","that","contributes","to","cytokine","production","by","a","myeloid","cell","."),3998743). assertion_content_comment('tOboGo_MyeloidLeukocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","myeloid","precursor","cell","acquires","the","specialized","features","of","any","cell","of","the","myeloid","leukocyte","lineage","."),3996686). assertion_content_comment('tOboGo_MyeloidLeukocyteMediatedImmunity',s("Any","process","involved","in","the","carrying","out","of","an","immune","response","by","a","myeloid","leukocyte","."),3982823). assertion_content_comment('tOboGo_MyeloidProgenitorCellDifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","myeloid","progenitor","cell",".","Myeloid","progenitor","cells","include","progenitor","cells","for","any","of","the","myeloid","lineages","."),4379865). assertion_content_comment('tOboGo_Myf5Binding',s("Interacting","selectively","and","non-covalently","with","the","muscle","regulatory","factor","Myf5","."),4284085). assertion_content_comment('tOboGo_MyoblastCellDifferentiationInvolvedInSkeletalMuscleRegeneration',s("The","process","in","which","a","relatively","unspecialized","satellite","cell","acquires","specialized","features","of","a","myoblast","cell",".","This","occurs","as","part","of","skeletal","muscle","regeneration",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038474). assertion_content_comment('tOboGo_MyoblastCellFateCommitmentInHead',s("The","process",",","taking","place","in","the","head",",","whereby","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","myoblast","cell",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4320668). assertion_content_comment('tOboGo_MyoblastCellFateCommitmentInTrunk',s("The","process","taking","place","in","the","trunk","whereby","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","myoblast","cell",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4320659). assertion_content_comment('tOboGo_MyoblastCellFateCommitmentInvolvedInSkeletalMuscleRegeneration',s("The","process","in","which","the","developmental","fate","of","a","satellite","cell","becomes","restricted","such","that","it","will","develop","into","a","myoblast","cell",".","This","occurs","as","part","of","skeletal","muscle","regeneration",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038476). assertion_content_comment('tOboGo_MyoblastCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","myoblast","cell",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4018435). assertion_content_comment('tOboGo_MyoblastCellFateDeterminationInvolvedInSkeletalMuscleRegeneration',s("The","process","in","which","a","satellite","cell","becomes","capable","of","differentiating","autonomously","into","a","myoblast","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed",".","This","occurs","as","part","of","skeletal","muscle","regeneration",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038506). assertion_content_comment('tOboGo_MyoblastCellFateDetermination',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","myoblast","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4018445). assertion_content_comment('tOboGo_MyoblastCellFateSpecificationInvolvedInSkeletalMuscleRegeneration',s("The","process","in","which","a","satellite","cell","becomes","capable","of","differentiating","autonomously","into","a","myoblast","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",".","Upon","specification",",","the","cell","fate","can","be","reversed",".","This","occurs","as","part","of","skeletal","muscle","regeneration",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038496). assertion_content_comment('tOboGo_MyoblastCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","myoblast","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",".","Upon","specification",",","the","cell","fate","can","be","reversed",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038493). assertion_content_comment('tOboGo_MyoblastCellProliferationInvolvedInSkeletalMuscleRegeneration',s("The","multiplication","or","reproduction","of","myoblast","cells",",","resulting","in","the","expansion","of","the","cell","population",".","This","occurs","as","part","of","skeletal","muscle","regeneration",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038769). assertion_content_comment('tOboGo_MyoblastDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","myoblast","over","time",",","from","its","formation","to","the","mature","structure",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4106556). assertion_content_comment('tOboGo_MyoblastDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","myoblast",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","striated","muscle","fibers","."),4018432). assertion_content_comment('tOboGo_MyoblastDivision',s("The","process","resulting","in","the","physical","partitioning","and","separation","of","a","myoblast","into","daughter","cells",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4320941). assertion_content_comment('tOboGo_MyoblastFusionInvolvedInSkeletalMuscleRegeneration',s("A","process","in","which","non-proliferating","myoblasts",",","after","migrating","to","the","site","of","injury",",","fuse","into","existing","damaged","fibers","or","fuse","to","myotubes","to","form","new","fibers",",","as","part","of","the","process","of","skeletal","muscle","regeneration",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038869). assertion_content_comment('tOboGo_MyoblastFusion',s("A","process","in","which","non-proliferating","myoblasts","fuse","to","existing","fibers","or","to","myotubes","to","form","new","fibers",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4018415). assertion_content_comment('tOboGo_MyoblastMaturationInvolvedInMuscleRegeneration',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","myoblast","cell","to","attain","its","fully","functional","state","involved","in","muscle","regeneration",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4289280). assertion_content_comment('tOboGo_MyoblastMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","myoblast","to","attain","its","fully","functional","state",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4106566). assertion_content_comment('tOboGo_MyoblastMigrationInvolvedInSkeletalMuscleRegeneration',s("The","process","in","which","a","myoblast","migrates","along","an","entire","fiber","to","the","site","of","injury",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038455). assertion_content_comment('tOboGo_MyoblastMigration',s("The","orderly","movement","of","a","myoblast","from","one","site","to","another",",","often","during","the","development","of","a","multicellular","organism",".","A","myoblast","is","a","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038452). assertion_content_comment('tOboGo_MyoblastProliferation',s("The","multiplication","or","reproduction","of","myoblasts",",","resulting","in","the","expansion","of","a","myoblast","cell","population",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4038766). assertion_content_comment('tOboGo_MyocardialEpithelialInvolutionInvolvedInHeartJogging',s("The","morphogenetic","process","in","which","the","myocardium","bends","along","a","linear","axis","and","contributes","to","the","process","of","heart","jogging","."),4001882). assertion_content_comment('tOboGo_MyoDBinding',s("Interacting","selectively","and","non-covalently","with","the","muscle","regulatory","factor","MyoD","."),4284076). assertion_content_comment('tOboGo_MyofibrilAssembly',s("Formation","of","myofibrils",",","the","repeating","units","of","striated","muscle","."),4049123). assertion_content_comment('tOboGo_Myofibril',s("The","contractile","element","of","skeletal","and","cardiac","muscle",";","a","long",",","highly","organized","bundle","of","actin",",","myosin",",","and","other","proteins","that","contracts","by","a","sliding","filament","mechanism","."),4008506). assertion_content_comment('tOboGo_MyogeninBinding',s("Interacting","selectively","and","non-covalently","with","the","muscle","regulatory","factor","myogenin","."),4284106). assertion_content_comment('tOboGo_MyoinhibitoryHormoneActivity',s("The","action","characteristic","of","myostimulatory","hormone",",","a","peptide","hormone","that","inhibits","muscle","contraction","."),4303400). assertion_content_comment('tOboGo_MyopalladinBinding',s("Interacting","selectively","and","non-covalently","with","myopalladin",",","a","myofibrillar","protein","with","titin-like","Ig","domains","."),4324757). assertion_content_comment('tOboGo_MyosinATPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",".","The","hydrolysis","of","ATP","by","myosin","that","provides","the","energy","for","actomyosin","contraction","."),4252617). assertion_content_comment('tOboGo_MyosinBinding',s("Interacting","selectively","and","non-covalently","with","any","part","of","a","myosin","complex",";","myosins","are","any","of","a","superfamily","of","molecular","motor","proteins","that","bind","to","actin","and","use","the","energy","of","ATP","hydrolysis","to","generate","force","and","movement","along","actin","filaments","."),4178653). assertion_content_comment('tOboGo_MyosinComplex',s("A","protein","complex",",","formed","of","one","or","more","myosin","heavy","chains","plus","associated","light","chains","and","other","proteins",",","that","functions","as","a","molecular","motor",";","uses","the","energy","of","ATP","hydrolysis","to","move","actin","filaments","or","to","move","vesicles","or","other","cargo","on","fixed","actin","filaments",";","has","magnesium-ATPase","activity","and","binds","actin",".","Myosin","classes","are","distinguished","based","on","sequence","features","of","the","motor",",","or","head",",","domain",",","but","also","have","distinct","tail","regions","that","are","believed","to","bind","specific","cargoes","."),4008542). assertion_content_comment('tOboGo_MyosinFilamentAssemblyOrDisassembly',s("The","formation","or","disassembly","of","a","filament","composed","of","myosin","molecules","."),4049157). assertion_content_comment('tOboGo_MyosinFilamentAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","filament","composed","of","myosin","molecules","."),4049161). assertion_content_comment('tOboGo_MyosinFilamentDisassembly',s("The","disassembly","of","a","filament","composed","of","myosin","molecules","."),4094499). assertion_content_comment('tOboGo_MyosinFilament',s("A","protein","complex","containing","myosin","heavy","chains",",","plus","associated","light","chains","and","other","proteins",",","in","which","the","myosin","heavy","chains","are","arranged","into","a","filament","."),4008558). assertion_content_comment('tOboGo_MyosinHeadNeckBinding',s("Interacting","selectively","and","non-covalently","with","the","head/neck","region","of","a","myosin","heavy","chain","."),4178723). assertion_content_comment('tOboGo_MyosinHeavyChainBinding',s("Interacting","selectively","and","non-covalently","with","a","heavy","chain","of","a","myosin","complex","."),4178656). assertion_content_comment('tOboGo_MyosinHeavyChainKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","myosin-heavy-chain","=","ADP","+","myosin-heavy-chain","phosphate","."),4302102). assertion_content_comment('tOboGo_MyosinIBinding',s("Interacting","selectively","and","non-covalently","with","a","class","I","myosin",";","myosin","I","heavy","chains","are","single-headed",",","possess","tails","of","various","lengths",",","and","do","not","self-associate","into","bipolar","filaments","."),4268706). assertion_content_comment('tOboGo_MyosinIComplex',s("A","myosin","complex","containing","a","class","I","myosin","heavy","chain","and","associated","light","chains",";","myosin","I","heavy","chains","are","single-headed",",","possess","tails","of","various","lengths",",","and","do","not","self-associate","into","bipolar","filaments",";","myosin","I","complexes","are","involved","in","diverse","processes","related","to","membrane","traffic","and","cell","movement","."),4300293). assertion_content_comment('tOboGo_MyosinIHeadNeckBinding',s("Interacting","selectively","and","non-covalently","with","the","head/neck","region","of","a","myosin","I","heavy","chain","."),4330775). assertion_content_comment('tOboGo_MyosinIHeavyChainBinding',s("Interacting","selectively","and","non-covalently","with","a","heavy","chain","of","a","myosin","I","complex","."),4330773). assertion_content_comment('tOboGo_MyosinIIBinding',s("Interacting","selectively","and","non-covalently","with","a","class","II","myosin",",","any","member","of","the","class","of","'","conventional","'","double-headed","myosins","that","includes","muscle","myosin","."),4300398). assertion_content_comment('tOboGo_MyosinIIComplex',s("A","myosin","complex","containing","two","class","II","myosin","heavy","chains",",","two","myosin","essential","light","chains","and","two","myosin","regulatory","light","chains",".","Also","known","as","classical","myosin","or","conventional","myosin",",","the","myosin","II","class","includes","the","major","muscle","myosin","of","vertebrate","and","invertebrate","muscle",",","and","is","characterized","by","alpha-helical","coiled","coil","tails","that","self","assemble","to","form","a","variety","of","filament","structures","."),4008544). assertion_content_comment('tOboGo_MyosinIIFilamentAssemblyOrDisassembly',s("The","formation","or","disassembly","of","a","bipolar","filament","composed","of","myosin","II","molecules","."),4094457). assertion_content_comment('tOboGo_MyosinIIFilamentAssembly',s("The","formation","of","a","bipolar","filament","composed","of","myosin","II","molecules","."),4094460). assertion_content_comment('tOboGo_MyosinIIFilamentDisassembly',s("The","disassembly","of","a","bipolar","filament","composed","of","myosin","II","molecules","."),4094503). assertion_content_comment('tOboGo_MyosinIIHeadNeckBinding',s("Interacting","selectively","and","non-covalently","with","the","head/neck","region","of","a","myosin","II","heavy","chain","."),4330755). assertion_content_comment('tOboGo_MyosinIIHeavyChainBinding',s("Interacting","selectively","and","non-covalently","with","a","heavy","chain","of","a","myosin","II","complex","."),4330753). assertion_content_comment('tOboGo_MyosinIIIBinding',s("Interacting","selectively","and","non-covalently","with","a","class","III","myosin",";","myosin","III","is","monomeric","and","has","an","N","terminal","kinase","domain","."),4321617). assertion_content_comment('tOboGo_MyosinIIIComplex',s("A","myosin","complex","containing","a","class","III","myosin","heavy","chain","and","associated","light","chains",";","myosin","III","is","monomeric","myosin","that","serves","as","a","link","between","the","cytoskeleton","and","the","signaling","complex","involved","in","phototransduction",",","and","differs","from","all","other","myosins","in","having","an","N-terminal","kinase","domain","."),4312827). assertion_content_comment('tOboGo_MyosinIILightChainBinding',s("Interacting","selectively","and","non-covalently","with","a","light","chain","of","a","myosin","II","complex","."),4330735). assertion_content_comment('tOboGo_MyosinIITailBinding',s("Interacting","selectively","and","non-covalently","with","the","tail","region","of","a","myosin","II","heavy","chain","."),4330804). assertion_content_comment('tOboGo_MyosinILightChainBinding',s("Interacting","selectively","and","non-covalently","with","a","light","chain","of","a","myosin","I","complex","."),4330814). assertion_content_comment('tOboGo_MyosinITailBinding',s("Interacting","selectively","and","non-covalently","with","the","tail","region","of","a","myosin","I","heavy","chain","."),4330794). assertion_content_comment('tOboGo_MyosinIVComplex',s("A","myosin","complex","containing","one","or","more","class","IV","myosin","heavy","chains","and","associated","light","chains",";","myosin","IV","is","relatively","uncharacterized",",","but","is","predicted","to","have","a","single","motor","domain",",","one","IQ","motif","and","a","tail","with","a","Myosin","Tail","Homology","(","myTH4",")","domain","homologous","to","that","in","the","tails","of","myosins","VII","and","XV","."),4321665). assertion_content_comment('tOboGo_MyosinIXComplex',s("A","myosin","complex","containing","a","class","IX","myosin","heavy","chain","and","associated","light","chains",".","Myosin","IX","is","monomeric","with","a","motor","domain","containing","an","N-terminal","extension","and","an","insert","in","the","actin","binding","interface",",","followed","by","four","to","six","IQ","motifs","and","a","tail","region","that","contains","a","zinc","binding","motif","and","a","domain","with","homology","to","GTPase","activating","proteins","(","GAPs",")","of","the","Rho","family","of","G-proteins","."),4321578). assertion_content_comment('tOboGo_MyosinLightChainBinding',s("Interacting","selectively","and","non-covalently","with","a","light","chain","of","a","myosin","complex","."),4178704). assertion_content_comment('tOboGo_MyosinLightChainKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","myosin-light-chain","=","ADP","+","myosin-light-chain","phosphate","."),4202800). assertion_content_comment('tOboGo_MyosinPhosphataseActivity',s("Catalysis","of","the","reaction",":","phosphomyosin","+","H2O","=","myosin","+","phosphate","."),4268765). assertion_content_comment('tOboGo_MyosinPhosphataseComplex',s("An","enzyme","complex","that","catalyzes","the","removal","of","the","phosphate","group","from","phosphomyosin","."),4268697). assertion_content_comment('tOboGo_MyosinPhosphataseMyosinBinding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4268771). assertion_content_comment('tOboGo_MyosinPhosphataseRegulatorActivity',s("Modulation","of","the","activity","of","the","enzyme","myosin","phosphatase","."),4268746). assertion_content_comment('tOboGo_MyosinTailBinding',s("Interacting","selectively","and","non-covalently","with","the","tail","region","of","a","myosin","heavy","chain","."),4181814). assertion_content_comment('tOboGo_MyosinVBinding',s("Interacting","selectively","and","non-covalently","with","a","class","V","myosin",";","myosin","V","is","a","dimeric","molecule","involved","in","intracellular","transport","."),4321731). assertion_content_comment('tOboGo_MyosinVComplex',s("A","myosin","complex","containing","a","dimer","of","class","V","myosin","heavy","chains","and","associated","light","chains",";","involved","in","intracellular","transport",".","Myosin","V","is","a","dimeric","molecule","consisting","of","conserved","motor","domains","followed","by","6","IQ","motifs","which","bind","specific","light","chains","and","calmodulin",".","The","tail","domain","is","important","for","cellular","localization","and","cargo","binding","and","can","be","divided","into","an","alpha-helical","coiled","coil","region","and","a","C-terminal","globular","region","."),4321674). assertion_content_comment('tOboGo_MyosinVIBinding',s("Interacting","selectively","and","non-covalently","with","a","class","VI","myosin",".","The","myosin","VI","heavy","chain","has","a","single","IQ","motif","in","the","neck","and","a","tail","region","with","a","coiled","coil","domain","followed","by","a","unique","globular","domain",",","a","unique","insertion","that","enables","myosin","VI","to","move","towards","the","pointed","or","minus","end","of","actin","filaments","."),4178666). assertion_content_comment('tOboGo_MyosinVIComplex',s("A","myosin","complex","containing","one","or","more","class","VI","myosin","heavy","chains","and","associated","light","chains",".","Myosin","VI","has","a","single","IQ","motif","in","the","neck","and","a","tail","region","with","a","coiled","coil","domain","followed","by","a","unique","globular","domain",";","a","unique","insertion","that","enables","myosin","VI","to","move","towards","the","pointed","or","minus","end","of","actin","filaments","."),4321647). assertion_content_comment('tOboGo_MyosinVIHeadNeckBinding',s("Interacting","selectively","and","non-covalently","with","the","head/neck","region","of","a","myosin","VI","heavy","chain","."),4178726). assertion_content_comment('tOboGo_MyosinVIHeavyChainBinding',s("Interacting","selectively","and","non-covalently","with","a","heavy","chain","of","a","myosin","VI","complex","."),4178668). assertion_content_comment('tOboGo_MyosinVIIComplex',s("A","myosin","complex","containing","a","dimer","of","class","VII","myosin","heavy","chains","and","associated","light","chains",".","Myosin","VII","(","240","kDa",")","is","predicted","to","be","a","dimeric","molecule","with","5","IQ","motifs","and","a","tail","region","with","a","short","stretch","of","coiled","coil","followed","by","two","myosin-tail","homology","(","MyTH4",")","domains",",","two","talin-binding","(","FERM",")","domains","and","an","SH3-domain","."),4321656). assertion_content_comment('tOboGo_MyosinVIIIComplex',s("A","myosin","complex","containing","a","dimer","of","class","VIII","myosin","heavy","chains","and","associated","light","chains",".","Myosin","VIII","is","predicted","to","be","dimeric",",","and","contain","an","unusual","100-190","residue","N-terminal","extension","prior","to","their","motor","domains",",","3-4","IQ","motifs",",","a","short","region","(","~","70","residues",")","of","predicted","alpha-helical","coiled","coil","and","a","C-terminal","domain","."),4321587). assertion_content_comment('tOboGo_MyosinVILightChainBinding',s("Interacting","selectively","and","non-covalently","with","a","light","chain","of","a","myosin","VI","complex","."),4178707). assertion_content_comment('tOboGo_MyosinXComplex',s("A","myosin","complex","containing","one","or","more","class","X","myosin","heavy","chains","and","associated","light","chains","."),4321497). assertion_content_comment('tOboGo_MyosinXIComplex',s("A","myosin","complex","containing","a","dimer","of","class","XI","myosin","heavy","chains","and","associated","light","chains",".","Myosin","XI","heavy","chain","sizes","are","similar","in","molecular","structure","to","the","class","V","myosins","with","5","to","6","IQ","motifs","and","tail","regions","with","predicted","coiled","coil","domains","(","forming","dimeric","molecules",")","and","large","C-terminal","regions","."),4321506). assertion_content_comment('tOboGo_MyosinXIIComplex',s("A","myosin","complex","containing","one","or","more","class","XII","myosin","heavy","chains","and","associated","light","chains",";","myosin","XII","contains","a","large","tail","region","with","two","MyTH4","domains","and","a","short","region","of","coiled","coil","."),4321515). assertion_content_comment('tOboGo_MyosinXIIIComplex',s("A","myosin","complex","containing","one","or","more","class","XIII","myosin","heavy","chains","and","associated","light","chains","."),4321524). assertion_content_comment('tOboGo_MyosinXITailBinding',s("Interacting","selectively","and","non-covalently","with","the","tail","region","of","a","myosin","XI","heavy","chain","."),4181816). assertion_content_comment('tOboGo_MyosinXIVComplex',s("A","myosin","complex","containing","a","class","XIV","myosin","heavy","chain","and","associated","light","chains",";","myosin","XIV","heavy","chains","are","the","simplest","known",",","containing","a","motor","domain",",","no","classic","IQ","motif","and","variable","length","tails","."),4321533). assertion_content_comment('tOboGo_MyosinXVComplex',s("A","myosin","complex","containing","a","class","XV","myosin","heavy","chain","and","associated","light","chains",".","Myosin","XV","is","single","headed",",","and","has","a","large","extension","(","1200aa",")","at","the","N-terminus","of","the","motor","domain",",","two","IQ","motifs","and","a","tail","with","a","similar","domain","structure","to","that","of","the","tail","of","myosin","VII","."),4321542). assertion_content_comment('tOboGo_MyosinXVIComplex',s("A","myosin","complex","containing","a","class","XVI","myosin","heavy","chains","and","associated","light","chains",";","myosin","XVI","heavy","chains","contain","ankyrin","repeat","."),4321551). assertion_content_comment('tOboGo_MyosinXVIIComplex',s("A","myosin","complex","containing","one","or","more","class","XVII","myosin","heavy","chains","and","associated","light","chains","."),4321560). assertion_content_comment('tOboGo_MyosinXVIIIComplex',s("A","myosin","complex","containing","a","class","XVIII","myosin","heavy","chain","and","associated","light","chains",";","myosin","XVIII","heavy","chains","contain","an","N-terminal","PDZ","domain","."),4321569). assertion_content_comment('tOboGo_MyostimulatoryHormoneActivity',s("The","action","characteristic","of","myostimulatory","hormone",",","a","peptide","hormone","that","stimulates","muscle","contraction","."),4303409). assertion_content_comment('tOboGo_MyosuppressinReceptorActivity',s("Combining","with","the","peptide","myosuppressin","to","initiate","a","change","in","cell","activity","."),4381878). assertion_content_comment('tOboGo_MyotilinBinding',s("Interacting","selectively","and","non-covalently","with","myotilin",",","a","structural","component","of","the","Z-discs","in","human","skeletal","and","cardiac","muscle",".","Its","C-terminus","contains","two","immunoglobulin-like","domains","and","the","unique","N-terminal","half","has","a","serine-rich","region",",","with","numerous","potential","phosphorylation","sites",",","and","a","stretch","of","hydrophobic","amino","acids",".","Myotilin","forms","homodimers","and","binds","to","alpha-actinin",",","F-actin",",","and","filamin","C","."),4286797). assertion_content_comment('tOboGo_MyotomeDevelopment',s("The","progression","of","the","myotome","over","time",",","from","its","formation","to","the","mature","structure",".","The","myotome","is","the","portion","of","the","somite","that","will","give","rise","to","muscle","."),4113435). assertion_content_comment('tOboGo_MyotubeCellDevelopmentInvolvedInSkeletalMuscleRegeneration',s("The","process","aimed","at","the","progression","of","a","myotube","cell","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell",".","This","occurs","as","part","of","the","process","of","skeletal","muscle","regeneration",".","Myotubes","are","multinucleated","cells","that","are","formed","when","proliferating","myoblasts","exit","the","cell","cycle",",","differentiate","and","fuse","."),4038859). assertion_content_comment('tOboGo_MyotubeCellDevelopment',s("The","process","aimed","at","the","progression","of","a","myotube","cell","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell",".","Myotubes","are","multinucleated","cells","that","are","formed","when","proliferating","myoblasts","exit","the","cell","cycle",",","differentiate","and","fuse","."),4038820). assertion_content_comment('tOboGo_MyotubeDifferentiationInvolvedInSkeletalMuscleRegeneration',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","myotube","cell",".","Myotube","differentiation","starts","with","myoblast","fusion","and","the","appearance","of","specific","cell","markers","(","this","is","the","cell","development","step",")","Then","individual","myotubes","can","fuse","to","form","bigger","myotubes","and","start","to","contract",".","This","process","occurs","as","part","of","the","process","of","skeletal","muscle","regeneration",".","Myotubes","are","multinucleated","cells","that","are","formed","when","proliferating","myoblasts","exit","the","cell","cycle",",","differentiate","and","fuse","."),4038849). assertion_content_comment('tOboGo_MyotubeDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","myotube","cell",".","Myotube","differentiation","starts","with","myoblast","fusion","and","the","appearance","of","specific","cell","markers","(","this","is","the","cell","development","step",")","Then","individual","myotubes","can","fuse","to","form","bigger","myotubes","and","start","to","contract",".","Myotubes","are","multinucleated","cells","that","are","formed","when","proliferating","myoblasts","exit","the","cell","cycle",",","differentiate","and","fuse","."),4018384). assertion_content_comment('tOboGo_MyrceneSynthaseActivity',s("Catalysis","of","the","reaction",":","geranyl","diphosphate","=","diphosphate","+","myrcene","."),4268967). assertion_content_comment('tOboGo_MyristoyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","myristoyl","(","CH3-","[","CH2","]","12-CO-",")","group","to","an","acceptor","molecule","."),4207377). assertion_content_comment('tOboGo_MyrtenalDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","myrtenal","+","H2O","=","2","H","+","+","2","e-","+","myrtenic","acid","."),4277466). assertion_content_comment('tOboGo_MyrtenolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","myrtenol","+","O2","+","2","H","+","+","2","e-","=","2","H2O","+","myrtenal","."),4281756). assertion_content_comment('tOboGo_MysteryCellDifferentiation',s("The","process","in","which","an","undifferentiated","cell","acquires","the","features","of","a","mystery","cell",".","The","mystery","cells","are","a","precluster","of","cells","that","emerge","from","the","compound","eye","morphogenetic","furrow",",","normally","positioned","between","R3","and","R4",".","They","then","disappear","into","the","surrounding","pool","of","undifferentiated","cells","and","have","no","known","fate","in","the","mature","ommatidium",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4020080). assertion_content_comment('tOboGo_MyxosporeFormation',s("The","process","in","which","differentiated",",","resting","cells","are","formed",",","usually","within","a","fruiting","body","by","Myxobacteria",".","The","myxospore","is","more","resistant","to","high","temperature",",","dessication",",","and","UV","than","vegetative","myxobacteria","."),4354860). assertion_content_comment('tOboGo_NACHTDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","NACHT","(","NAIP",",","CIITA",",","HET-E","and","TP1",")","domain",".","The","NACHT","domain","consists","of","seven","distinct","conserved","motifs",",","including","an","ATP/GTPase","specific","P-loop",",","a","Mg","(","2","+",")","-binding","site","and","five","more","specific","motifs","."),4330871). assertion_content_comment('tOboGo_NADBinding',s("Interacting","selectively","and","non-covalently","with","the","oxidized","form",",","NAD",",","of","nicotinamide","adenine","dinucleotide",",","a","coenzyme","involved","in","many","redox","and","biosynthetic","reactions","."),4175635). assertion_content_comment('tOboGo_NADBiosynthesisViaNicotinamideRibosideSalvagePathway',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","adenine","dinucleotide","(","NAD",")","from","the","vitamin","precursor","nicotinamide","riboside","."),4355404). assertion_content_comment('tOboGo_NADBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","adenine","dinucleotide",",","a","coenzyme","present","in","most","living","cells","and","derived","from","the","B","vitamin","nicotinic","acid",";","biosynthesis","may","be","of","either","the","oxidized","form",",","NAD",",","or","the","reduced","form",",","NADH","."),4258896). assertion_content_comment('tOboGo_NADCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nicotinamide","adenine","dinucleotide",",","a","coenzyme","present","in","most","living","cells","and","derived","from","the","B","vitamin","nicotinic","acid",";","catabolism","may","be","of","either","the","oxidized","form",",","NAD",",","or","the","reduced","form",",","NADH","."),4244733). assertion_content_comment('tOboGo_NADDiphosphataseActivity',s("Catalysis","of","the","reaction",":","NAD","+","+","H2O","=","AMP","+","NMN","."),4346529). assertion_content_comment('tOboGo_NADHBinding',s("Interacting","selectively","and","non-covalently","with","the","reduced","form",",","NADH",",","of","nicotinamide","adenine","dinucleotide",",","a","coenzyme","involved","in","many","redox","and","biosynthetic","reactions","."),4175674). assertion_content_comment('tOboGo_NADHDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NADH","+","H","+","+","acceptor","=","NAD","+","+","reduced","acceptor","."),4184627). assertion_content_comment('tOboGo_NADHDehydrogenaseComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","NADH","dehydrogenase","complex","."),4335461). assertion_content_comment('tOboGo_NADHDehydrogenaseComplexPlastoquinoneAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","NADH",":","plastoquinone","dehydrogenase","complex",",","which","is","involved","in","the","non-photochemical","reduction","of","plastoquinones",",","as","well","as","the","cyclic","electron","transport","around","photosystem","I","."),4335463). assertion_content_comment('tOboGo_NADHDehydrogenaseComplexPlastoquinone',s("An","NADH","dehydrogenase","complex","that","catalyzes","the","transfer","of","electrons","to","plastoquinone",".","The","complex","is","involved","in","the","non-photochemical","reduction","of","plastoquinones","and","the","cyclic","electron","transport","around","photosystem","I",",","and","is","found","in","plastid","thylakoids","."),4129028). assertion_content_comment('tOboGo_NADHDehydrogenaseComplex',s("An","integral","membrane","complex","that","possesses","NADH","oxidoreductase","activity",".","The","complex","is","one","of","the","components","of","the","electron","transport","chain",".","It","catalyzes","the","transfer","of","a","pair","of","electrons","from","NADH","to","a","quinone","."),4007670). assertion_content_comment('tOboGo_NADHDehydrogenasePlastoquinoneActivity',s("Catalysis","of","the","reaction",":","NADH","+","H","+","+","plastoquinone","=","NAD","+","+","plastoquinol","."),4322389). assertion_content_comment('tOboGo_NADHDehydrogenaseQuinoneActivity',s("Catalysis","of","the","reaction",":","NADH","+","H","+","+","a","quinone","=","NAD","+","+","a","quinol","."),4246488). assertion_content_comment('tOboGo_NADHDehydrogenaseUbiquinoneActivity',s("Catalysis","of","the","reaction",":","NADH","+","H","+","+","ubiquinone","=","NAD","+","+","ubiquinol","."),4246495). assertion_content_comment('tOboGo_NADHKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","NADH","=","ADP","+","2","H","(","+",")","+","NADPH","."),4316912). assertion_content_comment('tOboGo_NADHMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","reduced","nicotinamide","adenine","dinucleotide","(","NADH",")",",","a","coenzyme","present","in","most","living","cells","and","derived","from","the","B","vitamin","nicotinic","acid","."),4224377). assertion_content_comment('tOboGo_NADHOxidation',s("A","metabolic","process","that","results","in","the","oxidation","of","reduced","nicotinamide","adenine","dinucleotide",",","NADH",",","to","the","oxidized","form",",","NAD","."),4224387). assertion_content_comment('tOboGo_NADHPeroxidaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","(","2",")","+","H","(","+",")","+","NADH","=","2","H","(","2",")","O","+","NAD","(","+",")"),4305987). assertion_content_comment('tOboGo_NADHPyrophosphataseActivity',s("Catalysis","of","the","reaction",":","NADH","+","H2O","=","AMP","+","NMNH","+","2","H","+"),4378780). assertion_content_comment('tOboGo_NADHRegeneration',s("A","metabolic","process","that","generates","a","pool","of","NADH","by","the","reduction","of","NAD","+"),4229540). assertion_content_comment('tOboGo_NADKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","NAD","(","+",")","=","ADP","+","2","H","(","+",")","+","NADP","(","+",")"),4184505). assertion_content_comment('tOboGo_NADMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotinamide","adenine","dinucleotide","(","NAD",")",",","a","coenzyme","present","in","most","living","cells","and","derived","from","the","B","vitamin","nicotinic","acid","."),4224365). assertion_content_comment('tOboGo_NADNucleosidaseActivity',s("Catalysis","of","the","reaction",":","NAD","+","+","H2O","=","nicotinamide","+","ADP-ribose","."),4184538). assertion_content_comment('tOboGo_NADPBinding',s("Interacting","selectively","and","non-covalently","with","the","oxidized","form",",","NADP","+",",","of","nicotinamide-adenine","dinucleotide","phosphate",",","a","coenzyme","involved","in","many","redox","and","biosynthetic","reactions","."),4175596). assertion_content_comment('tOboGo_NADPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide-adenine","dinucleotide","phosphate",",","a","coenzyme","involved","in","many","redox","and","biosynthetic","reactions",";","biosynthesis","may","be","of","either","the","oxidized","form",",","NADP",",","or","the","reduced","form",",","NADPH","."),4229214). assertion_content_comment('tOboGo_NADPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nicotinamide-adenine","dinucleotide","phosphate",",","a","coenzyme","involved","in","many","redox","and","biosynthetic","reactions",";","catabolism","may","be","of","either","the","oxidized","form",",","NADP",",","or","the","reduced","form",",","NADPH","."),4229151). assertion_content_comment('tOboGo_NADPHBinding',s("Interacting","selectively","and","non-covalently","with","the","reduced","form",",","NADPH",",","of","nicotinamide-adenine","dinucleotide","phosphate",",","a","coenzyme","involved","in","many","redox","and","biosynthetic","reactions","."),4175609). assertion_content_comment('tOboGo_NADPHDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NADPH","+","H","+","+","quinone","acceptor","=","NADP","+","+","hydroquinone","."),4185277). assertion_content_comment('tOboGo_NADPHDehydrogenaseComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","NAD","(","P",")","H","dehydrogenase","complex",",","which","is","involved","in","electron","transport","from","an","unidentified","electron","donor",",","possibly","NAD","(","P",")","H","or","ferredoxin","(","Fd",")","to","the","plastoquinone","pool","."),4335261). assertion_content_comment('tOboGo_NADPHDehydrogenaseComplexPlastoquinone',s("Complex","that","possesses","NAD","(","P",")","H","dehydrogenase","(","plastoquinone",")","activity",".","The","complex","is","one","of","the","components","of","the","electron","transport","chain",".","It","is","involved","in","electron","transport","from","an","unidentified","electron","donor",",","possibly","NADH",",","NADPH","or","ferredoxin","(","Fd",")","to","the","plastoquinone","pool","."),4336310). assertion_content_comment('tOboGo_NADPHDehydrogenaseQuinoneActivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","H","+","H","+","+","a","quinone","=","NAD","(","P",")","+","+","a","hydroquinone","."),4184588). assertion_content_comment('tOboGo_NADPHDehydrogenase',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4251515). assertion_content_comment('tOboGo_NADPHNitroreductaseActivity',s("Catalysis","of","the","conversion","of","a","nitrate","group","to","an","amino","or","hydroxylamino","group","on","toluene","or","a","toluene","derivative","."),4278993). assertion_content_comment('tOboGo_NADPhosphorylationAndDephosphorylation',s("OBSOLETE",".","The","addition","or","removal","of","a","phosphate","group","from","nicotinamide","adenine","dinucleotide","(","NAD",")",",","a","coenzyme","present","in","most","living","cells","and","derived","from","the","B","vitamin","nicotinic","acid","."),4244777). assertion_content_comment('tOboGo_NADPHOxidaseActivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","H","+","H","+","+","O2","=","NAD","(","P",")","+","+","hydrogen","peroxide","."),4304075). assertion_content_comment('tOboGo_NADPHOxidaseComplex',s("A","enzyme","complex","of","which","the","core","is","a","heterodimer","composed","of","a","light","(","alpha",")","and","heavy","(","beta",")","chain",",","and","requires","several","other","water-soluble","proteins","of","cytosolic","origin","for","activity",".","Functions","in","superoxide","generation","by","the","NADPH-dependent","reduction","of","O2","."),4094035). assertion_content_comment('tOboGo_NADPHOxidation',s("A","metabolic","process","that","results","in","the","oxidation","of","reduced","nicotinamide","adenine","dinucleotide",",","NADPH",",","to","the","oxidized","form",",","NADP","."),4177771). assertion_content_comment('tOboGo_NADPHPeroxidaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","(","2",")","+","H","(","+",")","+","NADPH","=","2","H","(","2",")","O","+","NADP","(","+",")"),4271612). assertion_content_comment('tOboGo_NADPHPyrophosphataseActivity',s("Catalysis","of","the","reaction",":","NADPH","+","H2O","=","NMNH","+","ADP","."),4336099). assertion_content_comment('tOboGo_NADPH_QuinoneReductaseActivity',s("Catalysis","of","the","reaction",":","NADPH","+","H","+","+","quinone","=","NADP","+","+","semiquinone","."),4185184). assertion_content_comment('tOboGo_NADPHRegeneration',s("A","metabolic","process","that","generates","a","pool","of","NADPH","by","the","reduction","of","NADP","+"),4021184). assertion_content_comment('tOboGo_NADPH_SulfurOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","NADPH","+","S0","=","hydrogen","sulfide","+","NADP","."),4328578). assertion_content_comment('tOboGo_NADPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotinamide-adenine","dinucleotide","phosphate",",","a","coenzyme","involved","in","many","redox","and","biosynthetic","reactions",";","metabolism","may","be","of","either","the","oxidized","form",",","NADP",",","or","the","reduced","form",",","NADPH","."),4021163). assertion_content_comment('tOboGo_NADPNucleosidaseActivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","+","+","H2O","=","ADP-ribose","(","P",")","+","nicotinamide","."),4271580). assertion_content_comment('tOboGo_NADPPhosphataseActivity',s("Catalysis","of","the","reaction",":","H2O","+","NADP","+","=","NAD","+","+","phosphate","."),4237804). assertion_content_comment('tOboGo_NADPTranshydrogenaseActivity',s("Catalysis","of","the","reaction",":","NADPH","+","H","+","+","NAD","+","=","NADP","+","+","NADH","+","H","+"),4185340). assertion_content_comment('tOboGo_NADSalvage',s("Any","process","that","generates","nicotinamide","adenine","dinucleotide","(","NAD",")","from","derivatives","of","it",",","without","de","novo","synthesis",";","salvage","is","usually","from","the","degradation","products","nicotinic","acid","(","Na",")","and","nicotinamide","(","Nam",")"),4355433). assertion_content_comment('tOboGo_NADSynthaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","deamido-NAD","+","+","NH3","=","AMP","+","diphosphate","+","NAD","+"),4249014). assertion_content_comment('tOboGo_NADTransmembraneTransport',s("The","process","in","which","nicotinamide","adenine","dinucleotide","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore",";","transport","may","be","of","either","the","oxidized","form",",","NAD",",","or","the","reduced","form",",","NADH","."),4383081). assertion_content_comment('tOboGo_NADTransporterActivity',s("Enables","the","directed","movement","of","nicotinamide","adenine","dinucleotide","into",",","out","of","or","within","a","cell",",","or","between","cells",";","transport","may","be","of","either","the","oxidized","form",",","NAD",",","or","the","reduced","form",",","NADH","."),4280873). assertion_content_comment('tOboGo_NADTransport',s("The","directed","movement","of","nicotinamide","adenine","dinucleotide","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",";","transport","may","be","of","either","the","oxidized","form",",","NAD",",","or","the","reduced","form",",","NADH","."),4317475). assertion_content_comment('tOboGo_NalidixicAcidTransporterActivity',s("Enables","the","directed","movement","of","nalidixic","acid","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Nalidixic","acid","is","a","synthetic","antibiotic","that","interferes","with","DNA","gyrase","and","inhibits","prokaryotic","replication","."),4293013). assertion_content_comment('tOboGo_NalidixicAcidTransport',s("The","directed","movement","of","nalidixic","acid","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Nalidixic","acid","is","a","synthetic","antibiotic","that","interferes","with","DNA","gyrase","and","inhibits","prokaryotic","replication","."),4294196). assertion_content_comment('tOboGo_NALP1InflammasomeComplex',s("A","protein","complex","that","consists","of","three","components",",","NALP3",",","PYCARD","and","caspase-1",",","and","includes","among","its","functions","the","sensing","of","various","stimuli","including","anti-viral","compounds","R837","and","R848",",","bacterial","mRNA",",","gout-associated","crystals",",","bacterial","toxins","derived","from","Listeria","monocytogenes",",","Staphylococcus","aureus","and","Shigella","flexneri","."),4157870). assertion_content_comment('tOboGo_NALP3InflammasomeComplex',s("A","protein","complex","that","consists","of","three","components",",","IPAF",",","NAIP","and","caspase-1",",","and","includes","among","its","functions","the","sensing","of","flagellin","derived","from","Legionella","pneumophila",",","Salmonella","typhimurium",",","Pseudomonas","aeruginosa","and","Shigella","flexneri","."),4157860). assertion_content_comment('tOboGo_NaphthaleneHydroxylaseActivity',s("Catalysis","of","the","conversion","of","naphthalene","to","naphthalene","1",",","2-oxide","."),4255637). assertion_content_comment('tOboGo_NaphthaleneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","naphthalene",",","a","fused","ring","bicyclic","aromatic","hydrocarbon","commonly","found","in","crude","oil","and","oil","products",".","Naphthalene","is","familiar","as","the","compound","that","gives","mothballs","their","odor",";","it","is","used","in","the","manufacture","of","plastics",",","dyes",",","solvents",",","and","other","chemicals",",","as","well","as","being","used","as","an","antiseptic","and","insecticide","."),4272178). assertion_content_comment('tOboGo_NaphthalenesulfonateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","naphthalenesulfonate",",","sulfonated","derivatives","of","naphthalene","."),4272867). assertion_content_comment('tOboGo_NardilysinActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","polypeptides",",","preferably","at","the","first","bond","of","Xaa-Arg-Lys",",","and","less","commonly","at","the","first","bond","of","Arg-Arg-Xaa",",","in","which","Xaa","is","not","Arg","or","Lys","."),4301996). assertion_content_comment('tOboGo_NarrowPoreChannelActivity',s("Enables","the","transport","of","a","solute","across","a","membrane","via","a","narrow","pore","channel","that","may","be","gated","or","ungated","."),4331088). assertion_content_comment('tOboGo_NarrowPoreGatedChannelActivity',s("Enables","the","transport","of","a","solute","across","a","membrane","via","a","narrow","pore","channel","that","opens","in","response","to","a","particular","stimulus","."),4331090). assertion_content_comment('tOboGo_NatAComplex',s("A","conserved","complex","that","catalyzes","the","transfer","of","an","acetyl","group","to","an","N-terminal","Ser",",","Ala",",","Gly",",","or","Thr","residue","of","a","protein","acceptor","molecule",".","In","Saccharomyces","the","complex","includes","Nat1p","and","Ard1p",",","and","may","contain","additional","proteins","."),4319515). assertion_content_comment('tOboGo_NatBComplex',s("A","conserved","complex","that","catalyzes","the","transfer","of","an","acetyl","group","to","the","N-terminal","residue","of","a","protein","acceptor","molecule","that","has","a","Met-Glu",",","Met-Asp",",","Met-Asn",",","or","Met-Met","N-terminus",".","In","Saccharomyces","the","complex","includes","Nat3p","and","Mdm20p","."),4319449). assertion_content_comment('tOboGo_NatCComplex',s("A","conserved","complex","that","catalyzes","the","transfer","of","an","acetyl","group","to","the","N-terminal","residue","of","a","protein","acceptor","molecule","that","has","a","Met-Ile",",","Met-Leu",",","Met-Trp",",","or","Met-Phe","N-terminus",".","In","Saccharomyces","the","complex","includes","Mak3p",",","Mak10p",",","and","Mak31p","."),4319459). assertion_content_comment('tOboGo_Natriuresis',s("OBSOLETE",".","The","process","of","renal","sodium","excretion","."),4311126). assertion_content_comment('tOboGo_NatriureticPeptideReceptorActivity',s("Combining","with","a","natriuretic","peptide","to","initiate","a","change","in","cell","activity","."),4301919). assertion_content_comment('tOboGo_NaturalKillerCellActivationInvolvedInImmuneResponse',s("The","change","in","morphology","and","behavior","of","a","natural","killer","cell","resulting","from","exposure","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4070605). assertion_content_comment('tOboGo_NaturalKillerCellActivation',s("The","change","in","morphology","and","behavior","of","a","natural","killer","cell","in","response","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),3984604). assertion_content_comment('tOboGo_NaturalKillerCellApoptosis',s("The","process","of","apoptosis","in","a","natural","killer","cell","."),4137082). assertion_content_comment('tOboGo_NaturalKillerCellChemotaxis',s("The","directed","movement","of","a","natural","killer","cell","guided","by","a","specific","chemical","concentration","gradient",".","Movement","may","be","towards","a","higher","concentration","(","positive","chemotaxis",")","or","towards","a","lower","concentration","(","negative","chemotaxis",")"),4145672). assertion_content_comment('tOboGo_NaturalKillerCellCytokineProduction',s("Any","process","that","contributes","to","cytokine","production","by","a","natural","killer","cell","."),3998603). assertion_content_comment('tOboGo_NaturalKillerCellDegranulation',s("The","regulated","exocytosis","of","secretory","granules","containing","preformed","mediators","such","as","perforin","and","granzymes","by","a","natural","killer","cell","."),4095496). assertion_content_comment('tOboGo_NaturalKillerCellDifferentiationInvolvedInImmuneResponse',s("The","process","in","which","a","naive","natural","killer","cell","acquires","the","specialized","features","of","an","effector","natural","killer","T","cell","as","part","of","an","immune","response","."),4070699). assertion_content_comment('tOboGo_NaturalKillerCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","natural","killer","cell","."),4070694). assertion_content_comment('tOboGo_NaturalKillerCellInhibitorySignalingPathway',s("A","series","of","molecular","signals","initiated","by","the","binding","of","an","extracellular","ligand","to","a","receptor","on","the","surface","of","a","natural","killer","cell","capable","of","inhibiting","an","immune","effector","process","contributing","to","an","immune","response","."),4382454). assertion_content_comment('tOboGo_NaturalKillerCellMediatedCytotoxicityDirectedAgainstTumorCellTarget',s("The","directed","killing","of","a","tumor","cell","by","a","natural","killer","cell","through","the","release","of","granules","containing","cytotoxic","mediators","or","through","the","engagement","of","death","receptors","."),3999962). assertion_content_comment('tOboGo_NaturalKillerCellMediatedCytotoxicity',s("The","directed","killing","of","a","target","cell","by","a","natural","killer","cell","through","the","release","of","granules","containing","cytotoxic","mediators","or","through","the","engagement","of","death","receptors","."),3999951). assertion_content_comment('tOboGo_NaturalKillerCellMediatedImmuneResponseToTumorCell',s("An","immune","response","mediated","by","a","natural","killer","cell","triggered","in","response","to","the","presence","of","a","tumor","cell","."),3999938). assertion_content_comment('tOboGo_NaturalKillerCellMediatedImmunity',s("The","promotion","of","an","immune","response","by","natural","killer","cells","through","direct","recognition","of","target","cells","or","through","the","release","of","cytokines","."),3998599). assertion_content_comment('tOboGo_NaturalKillerCellProgenitorDifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","natural","killer","cell","progenitor","."),4379909). assertion_content_comment('tOboGo_NaturalKillerCellProliferationInvolvedInImmuneResponse',s("The","expansion","of","a","natural","killer","cell","population","by","cell","division","as","part","of","an","immune","response","."),4070609). assertion_content_comment('tOboGo_NaturalKillerCellProliferation',s("The","expansion","of","a","natural","killer","cell","population","by","cell","division","."),4070528). assertion_content_comment('tOboGo_NaturalKillerCellReceptorActivity',s("A","receptor","found","on","the","surface","of","natural","killer","cells","which","binds","Class","I","MHC","antigens","and","is","required","for","activation","of","NK","activity",".","It","belongs","to","the","Ly49i","family","."),4298887). assertion_content_comment('tOboGo_NaturalKillerCellToleranceInduction',s("Tolerance","induction","of","natural","killer","cells","."),4000653). assertion_content_comment('tOboGo_NBAFComplex',s("A","SWI/SNF-type","complex","that","is","found","in","post-mitotic","neurons",",","and","in","human","contains","actin","and","proteins","encoded","by","the","ARID1A/BAF250A","or","ARID1B/BAF250B",",","SMARCD1/BAF60A",",","SMARCD3/BAF60C",",","SMARCA2/BRM/BAF190B",",","SMARCA4/BRG1/BAF190A",",","SMARCB1/BAF47",",","SMARCC1/BAF155",",","SMARCE1/BAF57",",","SMARCC2/BAF170",",","DPF1/BAF45B",",","DPF3/BAF45C",",","ACTL6B/BAF53B","genes",".","The","nBAF","complex","along","with","CREST","plays","a","role","regulating","the","activity","of","genes","essential","for","dendrite","growth","."),4171190). assertion_content_comment('tOboGo_NcRNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","non-coding","RNA","transcripts","(","ncRNAs",")","Includes","the","breakdown","of","cryptic","unstable","transcripts","(","CUTs",")"),4143997). assertion_content_comment('tOboGo_NcRNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","non-coding","RNA","transcripts","(","ncRNAs",")"),3974817). assertion_content_comment('tOboGo_NcRNAPolyadenylation',s("The","enzymatic","addition","of","a","sequence","of","adenylyl","residues","at","the","3","'","end","of","a","non-coding","RNA","(","ncRNA",")","molecule",".","In","eukaryotes",",","substrates","include","nuclear","non-coding","RNAs","such","as","precursors","and","a","variety","of","incorrectly","processed","forms","of","snRNAs",",","snoRNAs",",","rRNAs",",","and","tRNAs",",","as","well","as","discarded","RNA","fragments","which","have","been","removed","from","ncRNA","primary","transcripts",".","Polyadenylation","of","precursors","is","often","linked","to","termination","of","transcription",",","but","polyadenylation","of","RNAs","targeted","for","degradation","may","also","occur","post-transcriptionally",".","This","polyadenylation","is","important","both","for","3","'","-end","processing","to","produce","mature","ncRNA","species","and","also","for","targeting","incorrectly","processed","or","discarded","RNA","molecules","for","degradation","."),4095176). assertion_content_comment('tOboGo_NcRNAProcessing',s("Any","process","that","results","in","the","conversion","of","one","or","more","primary","non-coding","RNA","(","ncRNA",")","transcripts","into","one","or","more","mature","ncRNA","molecules","."),3974832). assertion_content_comment('tOboGo_NDC1Complex',s("A","protein","complex","that","forms","part","of","the","nuclear","pore","complex",",","and","contains","three","transmembrane","nucleoporins",",","encoded","in","S",".","cerevisiae","by","Ndc1p",",","Pom152p","and","Pom34p","."),4132859). assertion_content_comment('tOboGo_Ndc80Complex',s("A","protein","complex","conserved","among","eukaryotes","that","forms","part","of","the","kinetochore","and","plays","an","essential","role","in","forming","stable","kinetochore-microtubule","attachments",".","The","complex","contains","proteins","known","in","several","species",",","including","budding","and","fission","yeasts",",","as","Ndc80p",",","Nuf2p",",","Spc24p",",","and","Spc25p",".","In","vertebrates","it","is","part","of","the","outer","plate","of","the","kinetochore","."),4062337). assertion_content_comment('tOboGo_NebenkernAssembly',s("Fusion","of","mitochondria","during","insect","spermatid","differentiation","to","form","two","masses",",","which","wrap","around","each","other","to","form","a","densely","packed","sphere","called","the","Nebenkern","."),4016760). assertion_content_comment('tOboGo_Nebenkern',s("A","product","of","the","fusion","of","the","mitochondria","during","spermatogenesis",".","After","the","completion","of","meiosis","the","mitochondria","of","the","spermatid","collect","along","side","the","nucleus","and","fuse","into","two","masses",";","these","wrap","around","each","other","to","produce","the","spherical","Nebenkern",".","During","flagellum","elongation","the","Nebenkern","unfolds","and","the","two","derivatives","(","major","and","minor","mitochondrial","derivatives",")","elongate","down","the","axoneme","."),4302723). assertion_content_comment('tOboGo_NebuletteBinding',s("Interacting","selectively","and","non-covalently","with","nebulette",",","a","107","kDa","protein","associated","with","the","I-Z-I","complex","of","cardiac","myofibrils",".","It","shows","a","high","degree","of","homology","with","skeletal","muscle","nebulin","."),4286806). assertion_content_comment('tOboGo_NebulinBinding',s("Interacting","selectively","and","non-covalently","with","nebulin",",","a","large","protein","(","approximately","800kD",")","that","is","anchored","at","the","Z-disc","by","its","C-terminal","region","and","spans","the","length","of","the","thin","filament",",","ending","at","the","edge","of","the","H-zone","."),4286766). assertion_content_comment('tOboGo_Necroptosis',s("A","necrotic","cell","death","process","that","results","from","the","activation","of","endogenous","cellular","processes",",","such","as","signaling","involving","death","domain","receptors","and","Toll-like","receptors","."),4116456). assertion_content_comment('tOboGo_Necrosis',s("OBSOLETE",".","The","processes","that","cause","necrosis",",","the","death","of","tissues",",","in","another","organism","."),4255834). assertion_content_comment('tOboGo_NecroticCellDeath',s("A","cell","death","process","that","is","morphologically","characterized","by","a","gain","in","cell","volume","(","oncosis",")",",","swelling","of","organelles",",","plasma","membrane","rupture","and","subsequent","loss","of","intracellular","contents","."),4034878). assertion_content_comment('tOboGo_NectarSecretion',s("The","controlled","release","of","a","nectar","by","a","cell",",","a","group","of","cells",",","or","a","tissue",".","Nectar","is","a","fluid","secreted","by","many","angiosperms","to","promote","pollination","by","providing","a","reward","to","pollinators",".","Nectar","may","also","deter","certain","organisms","from","visiting","or","play","other","biological","roles",".","Nectar","is","a","complex","solution","that","may","include","the","following","types","of","compounds",":","sugars",",","amino","acids",",","organic","acids",",","alkaloids",",","flavonoids",",","glycosides",",","vitamins",",","phenolics",",","metal","ions",",","oils",",","free","fatty","acids",",","and","proteins","."),4170862). assertion_content_comment('tOboGo_NectaryDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","floral","nectaries","over","time",",","from","its","formation","to","the","mature","structure","."),4031769). assertion_content_comment('tOboGo_NEDD8ActivatingEnzymeActivity',s("Catalysis","of","the","initiation","of","the","NEDD8","(","RUB1",")","conjugation","cascade","."),4245426). assertion_content_comment('tOboGo_NEDD8LigaseActivity',s("Catalysis","of","ATP-dependent","isopeptide","bond","formation","between","the","carboxy-terminal","residues","of","the","small","ubiquitin-related","modifier","NEDD8","and","a","substrate","lysine","residue","."),4245353). assertion_content_comment('tOboGo_NegativeAdaptationOfSignalingPathway',s("The","negative","regulation","of","a","signal","transduction","pathway","in","response","to","a","stimulus","upon","prolonged","exposure","to","that","stimulus","."),3991186). assertion_content_comment('tOboGo_NegativeAerotaxisInEnvironmentOfOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","environmental","oxygen","on",",","within","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196865). assertion_content_comment('tOboGo_NegativeAerotaxisInHostEnvironment',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","environmental","oxygen","on",",","within","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197542). assertion_content_comment('tOboGo_NegativeAerotaxisInHost',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","environmental","oxygen","within","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197627). assertion_content_comment('tOboGo_NegativeAerotaxisInOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","environmental","oxygen","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196885). assertion_content_comment('tOboGo_NegativeAerotaxisOnOrNearHost',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","environmental","oxygen","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197656). assertion_content_comment('tOboGo_NegativeAerotaxisOnOrNearOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","environmental","oxygen","on","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4197653). assertion_content_comment('tOboGo_NegativeAerotaxis',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","environmental","oxygen","."),4196847). assertion_content_comment('tOboGo_NegativeChemotaxisInEnvironmentOfOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","a","specific","chemical","on",",","within","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196861). assertion_content_comment('tOboGo_NegativeChemotaxisInHostEnvironment',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","a","specific","chemical","on",",","within","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197444). assertion_content_comment('tOboGo_NegativeChemotaxisInHost',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","a","specific","chemical","within","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197449). assertion_content_comment('tOboGo_NegativeChemotaxisInOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","a","specific","chemical","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196880). assertion_content_comment('tOboGo_NegativeChemotaxisOnOrNearHost',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","a","specific","chemical","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197462). assertion_content_comment('tOboGo_NegativeChemotaxisOnOrNearOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","a","specific","chemical","on","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196898). assertion_content_comment('tOboGo_NegativeChemotaxis',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","a","chemical","."),4034189). assertion_content_comment('tOboGo_NegativeCofactor2Complex',s("A","heterodimeric","protein","complex","that","can","stably","associate","with","TATA-binding","protein","on","promoters",",","thereby","preventing","the","assembly","of","transcription","factors","TFIIA","and","TFIIB","and","leading","to","repression","of","RNA","polymerase","II","transcription",".","The","two","subunits",",","NC2alpha","(","Drap1",")","and","NC2beta","(","Dr1",")",",","dimerize","through","histone","fold","domains","of","the","H2A/H2B","type","present","in","the","amino","termini","."),4269774). assertion_content_comment('tOboGo_NegativeEnergyTaxisInEnvironmentOfOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","on",",","within","or","near","a","second","organism","towards","a","lower","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196723). assertion_content_comment('tOboGo_NegativeEnergyTaxisInHostEnvironment',s("The","directed","movement","of","a","motile","cell","or","organism","on",",","within","or","near","its","host","organism","towards","a","lower","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197295). assertion_content_comment('tOboGo_NegativeEnergyTaxisInHost',s("The","directed","movement","of","a","motile","cell","or","organism","within","its","host","organism","towards","a","lower","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197324). assertion_content_comment('tOboGo_NegativeEnergyTaxisInOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","within","a","second","organism","towards","a","lower","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196765). assertion_content_comment('tOboGo_NegativeEnergyTaxisOnOrNearHost',s("The","directed","movement","of","a","motile","cell","or","organism","on","or","near","its","host","organism","towards","a","lower","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197300). assertion_content_comment('tOboGo_NegativeEnergyTaxisOnOrNearOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","on","or","near","a","second","organism","towards","a","lower","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196740). assertion_content_comment('tOboGo_NegativeEnergyTaxis',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates","."),4196707). assertion_content_comment('tOboGo_NegativeExtrathymicTCellSelection',s("The","process","of","elimination","of","extrathymically","maturing","T","cells","which","react","strongly","with","self-antigens","."),4300983). assertion_content_comment('tOboGo_NegativeGravitaxis',s("The","directed","movement","of","a","motile","cell","or","organism","away","from","the","source","of","gravity","."),4384624). assertion_content_comment('tOboGo_NegativeGravitropism',s("The","orientation","of","plant","parts","away","from","gravity","."),4262127). assertion_content_comment('tOboGo_NegativePhototaxis',s("The","directed","movement","of","a","cell","or","organism","away","from","a","source","of","light","."),4361972). assertion_content_comment('tOboGo_NegativeRegulationByHostOfCytolysisOfSymbiontCells',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cytolysis","by","that","organism","of","cells","in","its","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282368). assertion_content_comment('tOboGo_NegativeRegulationByHostOfSymbiontAdenylateCyclaseActivity',s("Any","process","in","which","the","host","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","symbiont","adenylate","cyclase","activity",",","which","catalyze","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154288). assertion_content_comment('tOboGo_NegativeRegulationByHostOfSymbiontCatalyticActivity',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","enzyme","activity",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154279). assertion_content_comment('tOboGo_NegativeRegulationByHostOfSymbiontDefenseResponse',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","defense","response","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197211). assertion_content_comment('tOboGo_NegativeRegulationByHostOfSymbiontMolecularFunction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","functional","activity","of","symbiont","proteins",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154270). assertion_content_comment('tOboGo_NegativeRegulationByHostOfSymbiontPeptidaseActivity',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","protease","activity",",","the","catalysis","of","the","hydrolysis","of","peptide","bonds","in","a","protein",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4188044). assertion_content_comment('tOboGo_NegativeRegulationByHostOfSymbiontProgrammedCellDeath',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","a","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4187441). assertion_content_comment('tOboGo_NegativeRegulationByHostOfSymbiontSignalTransductionPathway',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","symbiont","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153294). assertion_content_comment('tOboGo_NegativeRegulationByHostOfViralTranscription',s("Any","process","in","which","a","host","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","viral","transcription",",","the","synthesis","of","either","RNA","on","a","template","of","DNA","or","DNA","on","a","template","of","RNA","."),4328058). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfDefenseResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4120854). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfEntryIntoCellOfOtherOrganismViaPhagocytosisInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops","or","prevents","itself","undergoing","phagocytosis","into","a","cell","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4187615). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfEntryIntoOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","to","which","it","enters","into","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4146125). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfImmuneResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","immune","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction",".","The","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat","."),4186921). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfInflammatoryResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","inflammatory","response",";","the","inflammatory","response","is","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",",","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195137). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfInnateImmunityInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4194983). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfProgrammedCellDeathInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4187433). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfSignalTransductionPathwayInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","second","organism","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4152811). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfSymbiontImmuneResponse',s("OBSOLETE",".","Any","process","by","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","immune","response","of","the","symbiont","organism",";","the","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186901). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfSymbiontInflammatoryResponse',s("OBSOLETE",".","Any","process","by","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","inflammatory","response","of","a","symbiont","organism",";","the","inflammatory","response","is","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4187642). assertion_content_comment('tOboGo_NegativeRegulationByOrganismOfSymbiontInnateImmunity',s("OBSOLETE",".","Any","process","by","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","the","symbiont","organism",",","the","symbiont","'","s","first","line","of","defense","against","infection",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4187652). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfEntryIntoHostCellViaPhagocytosis',s("Any","process","in","which","an","organism","stops","or","prevents","itself","undergoing","phagocytosis","into","a","cell","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195664). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfEntryIntoHost',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","to","which","it","enters","into","the","host","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4146132). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostAdenylateCyclaseActivity',s("Any","process","in","which","the","symbiont","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","host","adenylate","cyclase","activity",",","which","catalyze","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153117). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostApoptosis',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","host",",","where","programmed","cell","death","proceeds","by","apoptosis",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4236840). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostCatalyticActivity',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","host","enzyme","activity",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153089). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostCellCycle',s("The","process","in","which","a","symbiont","organism","stops",",","prevents","or","reduces","the","rate","or","extent","of","its","host","'","s","progression","through","its","cell","cycle","via","direct","interactions","with","the","host","cell","macromolecular","machinery","."),4288710). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostDefenseResponse',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","defense","response","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4120862). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostImmuneResponse',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","immune","response","of","the","host","organism",";","the","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186928). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostInflammatoryResponse',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","inflammatory","response","of","the","host","organism",";","the","inflammatory","response","is","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195144). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostInnateImmunity',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","the","host","organism",",","the","host","'","s","first","line","of","defense","against","infection",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194992). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostMolecularFunction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","functional","activity","of","host","proteins",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153033). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostPeptidaseActivity',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","host","protease","activity",",","the","catalysis","of","the","hydrolysis","of","peptide","bonds","in","a","protein",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195435). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostProgrammedCellDeath',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195303). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostSignalTransductionPathway',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","host","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152819). assertion_content_comment('tOboGo_NegativeRegulationBySymbiontOfHostTranslation',s("The","process","in","which","a","symbiont","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","translation",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","protein",",","in","its","host","organism","."),4288721). assertion_content_comment('tOboGo_NegativeRegulationOfAbscisicAcidBiosyntheticProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","abscisic","acid","."),4150882). assertion_content_comment('tOboGo_NegativeRegulationOfAbscisicAcidMediatedSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","abscisic","acid","."),4022602). assertion_content_comment('tOboGo_NegativeRegulationOfAcetateCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate","."),4091185). assertion_content_comment('tOboGo_NegativeRegulationOfAcetylcholineMetabolicProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","involving","acetylcholine",",","the","acetic","acid","ester","of","the","organic","base","choline",".","Acetylcholine","is","a","major","neurotransmitter","and","neuromodulator","both","in","the","central","and","peripheral","nervous","systems",".","It","also","acts","as","a","paracrine","signal","in","various","non-neural","tissues","."),4117490). assertion_content_comment('tOboGo_NegativeRegulationOfAcetylcholineSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","acetylcholine","."),4039509). assertion_content_comment('tOboGo_NegativeRegulationOfAcetylcholineUptake',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","acetylcholine","into","a","cell","."),4121602). assertion_content_comment('tOboGo_NegativeRegulationOfActinCytoskeletonReorganization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","actin","cytoskeleton","reorganization","."),4140437). assertion_content_comment('tOboGo_NegativeRegulationOfActinFilamentBundleAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","assembly","of","actin","filament","bundles","."),4054485). assertion_content_comment('tOboGo_NegativeRegulationOfActinFilamentDepolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","actin","depolymerization","."),4051230). assertion_content_comment('tOboGo_NegativeRegulationOfActinFilamentPolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","actin","polymerization","."),4051045). assertion_content_comment('tOboGo_NegativeRegulationOfActinNucleation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","actin","nucleation",",","the","initial","step","in","the","formation","of","an","actin","filament","in","which","actin","monomers","combine","to","form","a","new","filament","."),4075128). assertion_content_comment('tOboGo_NegativeRegulationOfActinPolymerizationAndOrDepolymerization',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","actin","polymerization","and/or","depolymerization","."),4297797). assertion_content_comment('tOboGo_NegativeRegulationOfActionPotential',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","action","potential","creation",",","propagation","or","termination",".","An","action","potential","is","a","spike","of","membrane","depolarization","and","repolarization","that","travels","along","the","membrane","of","a","cell","."),4297806). assertion_content_comment('tOboGo_NegativeRegulationOfActivatedTCellAutonomousCellDeath',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lymphocyte","death","by","apoptosis","."),4137567). assertion_content_comment('tOboGo_NegativeRegulationOfActivatedTCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","activated","T","cell","proliferation","."),4091914). assertion_content_comment('tOboGo_NegativeRegulationOfActivationOfMembraneAttackComplex',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","activation","of","the","membrane","attack","complex","components","of","the","complement","cascade","."),3987658). assertion_content_comment('tOboGo_NegativeRegulationOfActivinReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","activity","of","any","activin","receptor","signaling","pathway","."),4064102). assertion_content_comment('tOboGo_NegativeRegulationOfActivinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","activin","from","a","cell","or","group","of","cells","."),4056212). assertion_content_comment('tOboGo_NegativeRegulationOfAcuteInflammatoryResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","acute","inflammatory","response","."),3983801). assertion_content_comment('tOboGo_NegativeRegulationOfAcuteInflammatoryResponseToAntigenicStimulus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","acute","inflammatory","response","to","an","antigenic","stimulus","."),3983856). assertion_content_comment('tOboGo_NegativeRegulationOfAdaptiveImmuneResponseBasedOnSomaticRecombinationOfImmuneReceptorsBuiltFromImmunoglobulinSuperfamilyDomains',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","adaptive","immune","response","based","on","somatic","recombination","of","immune","receptors","built","from","immunoglobulin","superfamily","domains",".","An","example","of","this","process","is","found","in","the","Gnathostomata","."),3983974). assertion_content_comment('tOboGo_NegativeRegulationOfAdaptiveImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","adaptive","immune","response","."),3983966). assertion_content_comment('tOboGo_NegativeRegulationOfAdenosineReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","adenosine","receptor","signaling","pathway",".","The","adenosine","receptor","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","an","adenosine","receptor","binding","to","one","of","its","physiological","ligands","."),4108486). assertion_content_comment('tOboGo_NegativeRegulationOfAdenosineTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","adenosine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053925). assertion_content_comment('tOboGo_NegativeRegulationOfAdenylateCyclaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","adenylate","cyclase","activity","."),4152963). assertion_content_comment('tOboGo_NegativeRegulationOfAdiponectinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","adiponectin","from","a","cell","or","group","of","cells","."),4133332). assertion_content_comment('tOboGo_NegativeRegulationOfAdrenergicReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","adrenergic","receptor","protein","signaling","pathway","activity",".","An","adrenergic","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","an","adrenergic","receptor","binding","to","one","of","its","physiological","ligands","."),4125514). assertion_content_comment('tOboGo_NegativeRegulationOfAdultSalivaryGlandBoundarySpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","salivary","gland","determination","in","an","adult","organism","."),4091664). assertion_content_comment('tOboGo_NegativeRegulationOfAeciosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","aeciospore","formation",",","a","process","in","which","a","dikaryotic","spore","of","typically","a","rust","fungus","is","produced","in","an","aecium","."),4148604). assertion_content_comment('tOboGo_NegativeRegulationOfAeciumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","aecium","development",",","a","process","in","which","a","cuplike","structure","containing","chains","of","aeciospores","is","formed","."),4148446). assertion_content_comment('tOboGo_NegativeRegulationOfAggregateSizeInvolvedInSorocarpDevelopment',s("Any","process","that","decreases","the","size","of","the","aggregate","formed","during","sorocarp","formation","."),4318897). assertion_content_comment('tOboGo_NegativeRegulationOfAldosteroneBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","aldosterone","."),4056111). assertion_content_comment('tOboGo_NegativeRegulationOfAldosteroneMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","aldosterone","."),4056094). assertion_content_comment('tOboGo_NegativeRegulationOfAlkalinePhosphataseActivity',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","alkaline","phosphatase","activity",",","the","catalysis","of","the","reaction",":","an","orthophosphoric","monoester","+","H2O","=","an","alcohol","+","phosphate",",","with","an","alkaline","pH","optimum","."),4336519). assertion_content_comment('tOboGo_NegativeRegulationOfAmineTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amines","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990731). assertion_content_comment('tOboGo_NegativeRegulationOfAminoAcidTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amino","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990739). assertion_content_comment('tOboGo_NegativeRegulationOfAminoAcidUptakeInvolvedInSynapticTransmission',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amino","acid","neurotransmitters","into","a","neuron","or","glial","cell","."),4120404). assertion_content_comment('tOboGo_NegativeRegulationOfAmyloidPrecursorProteinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","amyloid","precursor","protein","(","APP",")",",","the","precursor","of","beta-amyloid","."),4093783). assertion_content_comment('tOboGo_NegativeRegulationOfAnagen',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","anagen",",","the","growth","phase","of","the","hair","cycle","."),4122498). assertion_content_comment('tOboGo_NegativeRegulationOfAndrogenBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","androgen","biosynthetic","process","."),4140911). assertion_content_comment('tOboGo_NegativeRegulationOfAndrogenReceptorSignalingPathway',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","androgen","receptor","signaling","pathway","."),4111015). assertion_content_comment('tOboGo_NegativeRegulationOfAngiogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","angiogenesis","."),4040538). assertion_content_comment('tOboGo_NegativeRegulationOfAnionChannelActivityByBlueLight',s("Any","process","in","which","blue","light","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","the","anion","channel","activity","."),4332126). assertion_content_comment('tOboGo_NegativeRegulationOfAnionChannelActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","the","anion","channel","activity","."),4332113). assertion_content_comment('tOboGo_NegativeRegulationOfAnteriorNeuralCellFateCommitmentOfTheNeuralPlateByFibroblastGrowthFactorReceptorSignalingPathway',s("The","series","of","molecular","signals","that","stops",",","prevents","or","reduces","the","frequency","or","rate","at","which","cell","adopts","an","anterior","neural","cell","fate",",","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","."),4336820). assertion_content_comment('tOboGo_NegativeRegulationOfAnteriorNeuralCellFateCommitmentOfTheNeuralPlateByWntReceptorSignalingPathway',s("The","series","of","molecular","signals","that","stops",",","prevents","or","reduces","the","frequency","or","rate","at","which","a","cell","adopts","an","anterior","neural","cell","fate",",","initiated","by","binding","of","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","."),4336803). assertion_content_comment('tOboGo_NegativeRegulationOfAnteriorNeuralCellFateCommitmentOfTheNeuralPlate',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency","or","rate","at","which","a","cell","adopts","an","anterior","neural","cell","fate","."),4053213). assertion_content_comment('tOboGo_NegativeRegulationOfAnthocyaninBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","anthocyanins","."),4060645). assertion_content_comment('tOboGo_NegativeRegulationOfAnthocyaninMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","involving","anthocyanins","."),4060607). assertion_content_comment('tOboGo_NegativeRegulationOfAntibacterialPeptideBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","biosynthesis","."),4000822). assertion_content_comment('tOboGo_NegativeRegulationOfAntibacterialPeptideProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","production","."),3997507). assertion_content_comment('tOboGo_NegativeRegulationOfAntibacterialPeptideSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","secretion","."),3997632). assertion_content_comment('tOboGo_NegativeRegulationOfAntifungalPeptideBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","biosynthesis","."),4000931). assertion_content_comment('tOboGo_NegativeRegulationOfAntifungalPeptideProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","production","."),3997522). assertion_content_comment('tOboGo_NegativeRegulationOfAntifungalPeptideSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","secretion","."),3997684). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentationOfLipidAntigenViaMHCClassIb',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","lipid","antigen","via","MHC","class","Ib","."),3994918). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentationOfPeptideAntigen',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","."),3995032). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassIb',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","Ib","."),3995042). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassII',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","II","."),3996176). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassI',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","I","."),3995079). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentationOfPeptideOrPolysaccharideAntigenViaMHCClassII',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","antigen","(","peptide","or","polysaccharide",")","via","MHC","class","II","."),3994857). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentationOfPolysaccharideAntigenViaMHCClassII',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","polysaccharide","antigen","via","MHC","class","II","."),3994866). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","."),3994376). assertion_content_comment('tOboGo_NegativeRegulationOfAntigenProcessingAndPresentationViaMHCClassIb',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","antigen","via","MHC","class","Ib","."),3994899). assertion_content_comment('tOboGo_NegativeRegulationOfAntimicrobialHumoralResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","antimicrobial","humoral","response","."),4020559). assertion_content_comment('tOboGo_NegativeRegulationOfAntimicrobialPeptideBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","biosynthesis","."),3997617). assertion_content_comment('tOboGo_NegativeRegulationOfAntimicrobialPeptideProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","production","."),3997445). assertion_content_comment('tOboGo_NegativeRegulationOfAntimicrobialPeptideSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","secretion","."),3997344). assertion_content_comment('tOboGo_NegativeRegulationOfAntipodalCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","antipodal","cell","differentiation","."),4091528). assertion_content_comment('tOboGo_NegativeRegulationOfAntisenseRNATranscription',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","synthesis","of","antisense","RNA",",","an","RNA","molecule","complementary","in","sequence","to","another","RNA","or","DNA","molecule",",","which",",","by","binding","the","latter",",","acts","to","inhibit","its","function","and/or","completion","of","synthesis",",","on","a","template","of","DNA","."),4115607). assertion_content_comment('tOboGo_NegativeRegulationOfAplanosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","aplanospore","formation",",","a","process","in","which","a","nonmotile",",","asexual","spore","is","formed","within","a","cell","in","certain","algae","and","fungi","(","commonly","in","the","Phycomycetes",")",",","the","wall","of","aplanospore","is","distinct","from","that","of","the","parent","cell","."),4148259). assertion_content_comment('tOboGo_NegativeRegulationOfApoptosisInBoneMarrow',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","occurrence","or","rate","of","cell","death","by","apoptosis","in","the","bone","marrow","."),4082022). assertion_content_comment('tOboGo_NegativeRegulationOfApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","death","by","apoptosis","."),3999561). assertion_content_comment('tOboGo_NegativeRegulationOfApoptoticCellClearance',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","apoptotic","cell","clearance","."),4141764). assertion_content_comment('tOboGo_NegativeRegulationOfAppetite',s("Any","process","that","reduces","appetite","."),4330824). assertion_content_comment('tOboGo_NegativeRegulationOfAppressoriumFormationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","appressorium","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146994). assertion_content_comment('tOboGo_NegativeRegulationOfAppressoriumInitiationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","symbiont","appressorium","initiation","near","or","on","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147404). assertion_content_comment('tOboGo_NegativeRegulationOfAppressoriumMaturationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","symbiont","appressorium","maturation","in",",","near","or","on","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147010). assertion_content_comment('tOboGo_NegativeRegulationOfArbusculeFormationForNutrientAcquisitionFromHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","arbuscule","formation","for","nutrient","acquisition","from","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4148910). assertion_content_comment('tOboGo_NegativeRegulationOfARFProteinSignalTransduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ARF","protein","signal","transduction","."),4057016). assertion_content_comment('tOboGo_NegativeRegulationOfAscosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ascospore","formation",",","a","process","in","which","a","sexual","spore",",","named","ascospore",",","from","Ascomycete","fungi","was","produced","inside","an","ascus","."),4148156). assertion_content_comment('tOboGo_NegativeRegulationOfAscusDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ascus","development",",","a","saclike","structure","produced","by","fungi","of","the","phylum","Ascomycota","(","sac","fungi",")","in","which","sexually","produced","spores","(","ascospores",")",",","usually","four","or","eight","in","number",",","are","formed","."),4147953). assertion_content_comment('tOboGo_NegativeRegulationOfAsexualSporulationResultingInFormationOfACellularSpore',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","formation","of","a","cellular","spore","derived","from","the","products","of","mitosis","."),4096528). assertion_content_comment('tOboGo_NegativeRegulationOfAstrocyteChemotaxis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","astrocyte","chemotaxis","."),4142131). assertion_content_comment('tOboGo_NegativeRegulationOfAstrocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","astrocyte","differentiation","."),4107232). assertion_content_comment('tOboGo_NegativeRegulationOfAsymmetricCellDivision',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","asymmetric","cell","division","."),4090858). assertion_content_comment('tOboGo_NegativeRegulationOfATP_ADPAntiporterActivity',s("Any","process","that","stops","or","reduces","the","activity","of","an","ATP",":","ADP","antiporter","."),4178235). assertion_content_comment('tOboGo_NegativeRegulationOfATPaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","ATP","hydrolysis","by","an","ATPase","."),4337584). assertion_content_comment('tOboGo_NegativeRegulationOfAtrichoblastFateSpecification',s("Any","process","that","suppresses","atrichoblast","fate","specification","."),4032701). assertion_content_comment('tOboGo_NegativeRegulationOfAttachmentOfSpindleMicrotubulesToKinetochore',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","attachment","of","spindle","microtubules","to","the","kinetochore","."),4120737). assertion_content_comment('tOboGo_NegativeRegulationOfAuditoryReceptorCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","auditory","hair","cell","differentiation","."),4087138). assertion_content_comment('tOboGo_NegativeRegulationOfAuditoryReceptorCellFateSpecification',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","specifying","into","an","auditory","hair","cell","."),4033480). assertion_content_comment('tOboGo_NegativeRegulationOfAutophagicVacuoleSize',s("Any","process","that","reduces","autophagic","vacuole","size","."),4297859). assertion_content_comment('tOboGo_NegativeRegulationOfAutophagy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","autophagy",".","Autophagy","is","the","process","in","which","cells","digest","parts","of","their","own","cytoplasm","."),4030516). assertion_content_comment('tOboGo_NegativeRegulationOfAuxinMediatedSignalingPathway',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","auxin","mediated","signaling","pathway",".","Auxin","mediated","signaling","pathway","is","the","series","of","molecular","signals","generated","in","response","to","detection","of","auxin","."),4034782). assertion_content_comment('tOboGo_NegativeRegulationOfAuxinMetabolicProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","auxins",",","plant","hormones","that","regulate","aspects","of","plant","growth","."),4150826). assertion_content_comment('tOboGo_NegativeRegulationOfAxialMesodermalCellFateDetermination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","axial","mesoderm","cell","fate","determination","."),4102907). assertion_content_comment('tOboGo_NegativeRegulationOfAxialMesodermalCellFateSpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","axial","mesoderm","cell","fate","specification","."),4102871). assertion_content_comment('tOboGo_NegativeRegulationOfAxonemalMicrotubuleDepolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","depolymerization","of","the","specialized","microtubules","of","the","axoneme","."),4013339). assertion_content_comment('tOboGo_NegativeRegulationOfAxonExtensionInvolvedInAxonGuidance',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","axon","extension","involved","in","axon","guidance","."),4105496). assertion_content_comment('tOboGo_NegativeRegulationOfAxonExtensionInvolvedInRegeneration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","axon","extension","involved","in","regeneration","."),4107084). assertion_content_comment('tOboGo_NegativeRegulationOfAxonExtension',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","axon","outgrowth","."),4046655). assertion_content_comment('tOboGo_NegativeRegulationOfAxonogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","axonogenesis","."),4046648). assertion_content_comment('tOboGo_NegativeRegulationOfAxonRegeneration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","axon","regeneration","."),4106854). assertion_content_comment('tOboGo_NegativeRegulationOfBarrierSeptumFormation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","barrier","septum","formation",".","Barrier","septum","formation","is","he","assembly","and","arrangement","of","a","septum","that","spans","the","plasma","membrane","interface","between","progeny","cells","following","cytokinesis","."),4035421). assertion_content_comment('tOboGo_NegativeRegulationOfBasidiosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","basidiospore","formation",",","a","process","in","which","a","sexually","produced","fungal","spore","is","formed","on","a","basidium","in","the","fungi","basidiomycetes","."),4148114). assertion_content_comment('tOboGo_NegativeRegulationOfBasidiumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","basidium","development",",","a","process","that","leads","to","the","formation","of","basidium",",","a","small",",","specialized","club-shaped","structure","typically","bearing","four","basidiospores","at","the","tips","of","minute","projections",".","The","basidium","is","unique","to","basidiomycetes","and","distinguishes","them","from","other","kinds","of","fungi","."),4148039). assertion_content_comment('tOboGo_NegativeRegulationOfBasophilDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","basophil","differentiation","."),4087611). assertion_content_comment('tOboGo_NegativeRegulationOfBCellActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","B","cell","activation","."),3989396). assertion_content_comment('tOboGo_NegativeRegulationOfBCellAnergy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","B","cell","anergy","."),3998396). assertion_content_comment('tOboGo_NegativeRegulationOfBCellAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","B","cell","antigen","processing","and","presentation","."),3994465). assertion_content_comment('tOboGo_NegativeRegulationOfBCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","B","cell","apoptosis","."),3999579). assertion_content_comment('tOboGo_NegativeRegulationOfBCellChemotaxis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","B","cell","chemotaxis","."),4144957). assertion_content_comment('tOboGo_NegativeRegulationOfBCellCytokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","B","cell","cytokine","production","."),3998508). assertion_content_comment('tOboGo_NegativeRegulationOfBCellDeletion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","B","cell","deletion","."),3999671). assertion_content_comment('tOboGo_NegativeRegulationOfBCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","B","cell","differentiation","."),3989406). assertion_content_comment('tOboGo_NegativeRegulationOfBCellMediatedImmunity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","B","cell","mediated","immunity","."),3983977). assertion_content_comment('tOboGo_NegativeRegulationOfBCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","B","cell","proliferation","."),4062099). assertion_content_comment('tOboGo_NegativeRegulationOfBCellReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signaling","pathways","initiated","by","the","cross-linking","of","an","antigen","receptor","on","a","B","cell","."),4100795). assertion_content_comment('tOboGo_NegativeRegulationOfBCellToleranceInduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","B","cell","tolerance","induction","."),3995317). assertion_content_comment('tOboGo_NegativeRegulationOfBehavior',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","behavior",",","the","specific","actions","or","reactions","of","an","organism","in","response","to","external","or","internal","stimuli","."),3998149). assertion_content_comment('tOboGo_NegativeRegulationOfBeta2IntegrinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta","2","integrins","."),4090839). assertion_content_comment('tOboGo_NegativeRegulationOfBicoidMRNALocalization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","process","in","which","bicoid","mRNA","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4090243). assertion_content_comment('tOboGo_NegativeRegulationOfBileAcidBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","bile","acids","."),4132188). assertion_content_comment('tOboGo_NegativeRegulationOfBindingOfSpermToZonaPellucida',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","binding","of","sperm","to","the","zona","pellucida","."),4142894). assertion_content_comment('tOboGo_NegativeRegulationOfBinding',s("Any","process","that","stops","or","reduces","the","rate","or","extent","of","binding",",","the","selective","interaction","of","a","molecule","with","one","or","more","specific","sites","on","another","molecule","."),4154945). assertion_content_comment('tOboGo_NegativeRegulationOfBiomineralTissueDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","biomineral","tissue","development",",","the","formation","of","hard","tissues","that","consist","mainly","of","inorganic","compounds","."),4046746). assertion_content_comment('tOboGo_NegativeRegulationOfBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","substances","."),3971595). assertion_content_comment('tOboGo_NegativeRegulationOfBipolarCellGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","bipolar","cell","growth",",","polarized","growth","from","both","ends","of","a","cell","."),4118773). assertion_content_comment('tOboGo_NegativeRegulationOfBloodCoagulationCommonPathway',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","blood","coagulation",",","common","pathway","."),4140313). assertion_content_comment('tOboGo_NegativeRegulationOfBloodCoagulationExtrinsicPathway',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","blood","coagulation",",","extrinsic","pathway","."),4140269). assertion_content_comment('tOboGo_NegativeRegulationOfBloodCoagulationIntrinsicPathway',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","blood","coagulation",",","intrinsic","pathway","."),4140291). assertion_content_comment('tOboGo_NegativeRegulationOfBloodCoagulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","blood","coagulation","."),4027271). assertion_content_comment('tOboGo_NegativeRegulationOfBloodMicroparticleFormation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","blood","microparticle","formation","."),4143158). assertion_content_comment('tOboGo_NegativeRegulationOfBloodPressure',s("Any","process","in","which","the","force","of","blood","traveling","through","the","circulatory","system","is","decreased","."),3987381). assertion_content_comment('tOboGo_NegativeRegulationOfBloodVesselEndothelialCellMigration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","migration","of","the","endothelial","cells","of","blood","vessels","."),4094419). assertion_content_comment('tOboGo_NegativeRegulationOfBloodVesselMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","blood","vessel","morphogenesis","."),4141429). assertion_content_comment('tOboGo_NegativeRegulationOfBloodVesselRemodeling',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","blood","vessel","remodeling",",","the","reorganization","or","renovation","of","existing","blood","vessels","."),4114815). assertion_content_comment('tOboGo_NegativeRegulationOfBMKCascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","BMK","cascade","."),4136781). assertion_content_comment('tOboGo_NegativeRegulationOfBMPSignalingPathwayByExtracellularSequesteringOfBMP',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","BMP","signaling","pathway","by","binding","or","confining","BMP","within","the","extracellular","region",",","such","that","it","is","separated","from","other","components","of","the","signaling","pathway","."),4378324). assertion_content_comment('tOboGo_NegativeRegulationOfBMPSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","BMP","signaling","pathway","activity","."),4046811). assertion_content_comment('tOboGo_NegativeRegulationOfBorderFollicleCellDelamination',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","border","cell","delamination","."),4052144). assertion_content_comment('tOboGo_NegativeRegulationOfBranchElongationInvolvedInUretericBudBranchingByBMPSignalingPathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","resulting","in","the","reduction","of","the","frequency",",","rate","or","extent","of","branch","elongation","involved","in","ureteric","bud","branching",",","the","growth","of","a","branch","of","the","ureteric","bud","along","its","axis","."),4158099). assertion_content_comment('tOboGo_NegativeRegulationOfBranchElongationInvolvedInUretericBudBranching',s("Any","process","that","reduces","the","frequency",",","rate","or","extent","of","branch","elongation","involved","in","ureteric","bud","branching",",","the","growth","of","a","branch","of","the","ureteric","bud","along","its","axis","."),4123899). assertion_content_comment('tOboGo_NegativeRegulationOfBranchingInvolvedInLungMorphogenesis',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","process","in","which","a","highly","ordered","sequence","of","patterning","events","generates","the","branched","structures","of","the","lung",",","consisting","of","reiterated","combinations","of","bud","outgrowth",",","elongation",",","and","dichotomous","subdivision","of","terminal","units","."),4113514). assertion_content_comment('tOboGo_NegativeRegulationOfBranchingInvolvedInUretericBudMorphogenesis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","branching","involved","in","ureteric","bud","morphogenesis",",","the","process","in","which","the","branching","structure","of","the","ureteric","bud","is","generated","and","organized",".","The","ureteric","bud","is","an","epithelial","tube","that","grows","out","from","the","metanephric","duct",".","The","bud","elongates","and","branches","to","give","rise","to","the","ureter","and","kidney","collecting","tubules","."),4149444). assertion_content_comment('tOboGo_NegativeRegulationOfBranchingMorphogenesisOfANerve',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","branching","morphogenesis","of","a","nerve","."),4141529). assertion_content_comment('tOboGo_NegativeRegulationOfBranchiomericSkeletalMuscleDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","branchiomeric","skeletal","muscle","development",".","Branchiomeric","skeletal","muscle","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","branchiomeric","skeletal","muscle","over","time",",","from","its","formation","to","the","mature","structure","."),4039875). assertion_content_comment('tOboGo_NegativeRegulationOfBrassinosteroidBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","brassinosteroids","."),4029390). assertion_content_comment('tOboGo_NegativeRegulationOfBrownFatCellProliferation',s("Any","process","that","stops","or","decreases","the","rate","or","extent","of","brown","fat","cell","proliferation","."),4136764). assertion_content_comment('tOboGo_NegativeRegulationOfBudOutgrowthInvolvedInLungBranching',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","bud","outgrowth","involved","in","lung","branching","."),4135509). assertion_content_comment('tOboGo_NegativeRegulationOfCalciumInER',s("OBSOLETE",".","Any","process","that","reduces","the","concentration","of","calcium","in","the","ER","."),4297874). assertion_content_comment('tOboGo_NegativeRegulationOfCalciumIonImport',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","directed","movement","of","calcium","ions","into","a","cell","or","organelle","."),4152163). assertion_content_comment('tOboGo_NegativeRegulationOfCalciumIonTransportIntoCytosol',s("Any","process","that","decreases","the","rate","of","the","directed","movement","of","calcium","ions","into","the","cytosol","of","a","cell",".","The","cytosol","is","that","part","of","the","cytoplasm","that","does","not","contain","membranous","or","particulate","subcellular","components","."),4029786). assertion_content_comment('tOboGo_NegativeRegulationOfCalciumIonTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","calcium","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4029778). assertion_content_comment('tOboGo_NegativeRegulationOfCAMPBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4049878). assertion_content_comment('tOboGo_NegativeRegulationOfCAMPCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4050494). assertion_content_comment('tOboGo_NegativeRegulationOfCAMPMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4049861). assertion_content_comment('tOboGo_NegativeRegulationOfCanonicalWntReceptorSignalingPathwayInvolvedInControllingTypeBPancreaticCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","canonical","Wnt","receptor","signaling","pathway","modulating","the","rate","or","frequency","of","pancreatic","B","cell","proliferation","."),4138694). assertion_content_comment('tOboGo_NegativeRegulationOfCanonicalWntReceptorSignalingPathwayInvolvedInNeuralCrestCellDifferentiation',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","Wnt","receptor","signaling","pathway","through","beta-catenin","involved","in","neural","crest","cell","differentiation",".","The","Wnt","receptor","signaling","pathway","is","the","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","."),4127140). assertion_content_comment('tOboGo_NegativeRegulationOfCanonicalWntReceptorSignalingPathwayInvolvedInNeuralPlateAnteriorPosteriorPatternFormation',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","Wnt","receptor","signaling","pathway","through","beta-catenin","in","the","anterior","end","of","the","neural","plate",".","This","regulation","sets","up","a","Wnt","signaling","gradient","along","the","anterior/posterior","axis","."),4156303). assertion_content_comment('tOboGo_NegativeRegulationOfCanonicalWntReceptorSignalingPathway',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","Wnt","receptor","signaling","pathway","through","beta-catenin",",","the","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","."),4127135). assertion_content_comment('tOboGo_NegativeRegulationOfCarbohydrateMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","carbohydrate","."),4026555). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacCellFateSpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cardiac","cell","fate","specification","."),4003487). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacMuscleAdaptation',s("Any","process","that","decreases","the","rate",",","extent","or","frequency","of","the","process","in","which","cardiac","muscle","adapts",",","with","consequent","modifications","to","structural","and/or","functional","phenotypes",",","in","response","to","a","stimulus",".","Stimuli","include","contractile","activity",",","loading","conditions",",","substrate","supply",",","and","environmental","factors","."),4028840). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacMuscleCellApoptosis',s("Any","process","that","decreases","the","rate","or","extent","of","cardiac","cell","apoptosis",".","Cardiac","cell","apoptosis","is","a","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","cardiac","muscle","cell","and","result","in","its","death","."),4026368). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacMuscleCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cardiac","muscle","cell","proliferation","."),4109215). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacMuscleContraction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cardiac","muscle","contraction","."),4109467). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacMuscleFiberDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cardiac","muscle","fiber","development","."),4107606). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacMuscleHypertrophy',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","enlargement","or","overgrowth","of","all","or","part","of","the","heart","due","to","an","increase","in","size","(","not","length",")","of","individual","cardiac","muscle","fibers",",","without","cell","division","."),4028794). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacMuscleTissueDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cardiac","muscle","tissue","development","."),4107574). assertion_content_comment('tOboGo_NegativeRegulationOfCardiacMuscleTissueGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cardiac","muscle","growth","."),4107794). assertion_content_comment('tOboGo_NegativeRegulationOfCardioblastCellFateSpecification',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","specifying","into","a","cardioblast",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4003490). assertion_content_comment('tOboGo_NegativeRegulationOfCardioblastDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cardioblast","differentiation",",","the","process","in","which","a","relatively","unspecialized","mesodermal","cell","acquires","the","specialized","structural","and/or","functional","features","of","a","cardioblast",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4122414). assertion_content_comment('tOboGo_NegativeRegulationOfCaspaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","caspase","activity","."),4317595). assertion_content_comment('tOboGo_NegativeRegulationOfCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","substances","."),3979625). assertion_content_comment('tOboGo_NegativeRegulationOfCatagen',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","catagen",",","the","regression","phase","of","the","hair","cycle","."),4122343). assertion_content_comment('tOboGo_NegativeRegulationOfCatalyticActivityInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","enzyme","activity","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4153081). assertion_content_comment('tOboGo_NegativeRegulationOfCatalyticActivity',s("Any","process","that","stops","or","reduces","the","activity","of","an","enzyme","."),3972858). assertion_content_comment('tOboGo_NegativeRegulationOfCatecholamineMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","catecholamine","."),4089666). assertion_content_comment('tOboGo_NegativeRegulationOfCatecholamineSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","catecholamine","."),4026722). assertion_content_comment('tOboGo_NegativeRegulationOfCatecholamineUptakeInvolvedInSynapticTransmission',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","catecholamine","neurotransmitters","into","a","neuron","or","glial","cell","."),4120479). assertion_content_comment('tOboGo_NegativeRegulationOfCateninImportIntoNucleus',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","directed","movement","of","a","catenin","protein","from","the","cytoplasm","into","the","nucleus","."),4083140). assertion_content_comment('tOboGo_NegativeRegulationOfCD40SignalingPathway',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","signaling","via","the","CD40","signaling","pathway","."),4143424). assertion_content_comment('tOboGo_NegativeRegulationOfCD4BiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","CD4","."),4086247). assertion_content_comment('tOboGo_NegativeRegulationOfCellActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","activation","."),3989355). assertion_content_comment('tOboGo_NegativeRegulationOfCellAdhesionInVentricularZone',s("The","process","that","results","in","the","loss","of","attachments","of","a","cell","in","the","ventricular","zone","."),4050155). assertion_content_comment('tOboGo_NegativeRegulationOfCellAdhesionMediatedByIntegrin',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","cell","adhesion","mediated","by","integrin","."),4063668). assertion_content_comment('tOboGo_NegativeRegulationOfCellAdhesionMoleculeProduction',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","cell","adhesion","molecule","production",".","Cell","adhesion","molecule","production","is","the","appearance","of","a","cell","adhesion","molecule","as","a","result","of","its","biosynthesis","or","a","decrease","in","its","catabolism","."),4115200). assertion_content_comment('tOboGo_NegativeRegulationOfCellAdhesion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","adhesion","."),3987992). assertion_content_comment('tOboGo_NegativeRegulationOfCellAging',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","cell","aging",".","Cell","aging","is","the","progression","of","the","cell","from","its","inception","to","the","end","of","its","lifespan","."),4151033). assertion_content_comment('tOboGo_NegativeRegulationOfCellBudding',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","budding","."),4090725). assertion_content_comment('tOboGo_NegativeRegulationOfCellCommunicationByChemicalCoupling',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","cell","communication","via","chemical","coupling",".","Cell","communication","by","chemical","coupling","is","the","process","that","mediates","signaling","interactions","between","one","cell","and","another","cell","by","the","transfer","of","small",",","water-soluble","molecules","or","metabolites","between","their","adjacent","cytoplasms","via","intercellular","protein","channels","."),4026315). assertion_content_comment('tOboGo_NegativeRegulationOfCellCommunicationByElectricalCoupling',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","cell","communication","via","electrical","coupling",".","Cell","communication","via","electrical","coupling","is","the","process","that","mediates","signaling","interactions","between","one","cell","and","another","cell","by","transfer","of","current","between","their","adjacent","cytoplasms","via","intercellular","protein","channels","."),4026152). assertion_content_comment('tOboGo_NegativeRegulationOfCellCommunication',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","cell","communication",".","Cell","communication","is","the","process","that","mediates","interactions","between","a","cell","and","its","surroundings",".","Encompasses","interactions","such","as","signaling","or","attachment","between","one","cell","and","another","cell",",","between","a","cell","and","an","extracellular","matrix",",","or","between","a","cell","and","any","other","aspect","of","its","environment","."),3987869). assertion_content_comment('tOboGo_NegativeRegulationOfCellCycleArrestInResponseToNitrogenStarvation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency","or","rate","of","cell","cycle","arrest","in","response","to","nitrogen","starvation","."),4030428). assertion_content_comment('tOboGo_NegativeRegulationOfCellCycleArrest',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","cell","cycle","arrest",",","the","process","in","which","the","cell","cycle","is","halted","during","one","of","the","normal","phases","."),4030425). assertion_content_comment('tOboGo_NegativeRegulationOfCellCycleCytokinesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","division","of","the","cytoplasm","of","a","cell",",","and","its","separation","into","two","daughter","cells",",","that","occurs","in","the","context","of","cell","cycle","progression","."),4128392). assertion_content_comment('tOboGo_NegativeRegulationOfCellCycleProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","a","cellular","process","that","is","involved","in","the","progression","of","biochemical","and","morphological","phases","and","events","that","occur","in","a","cell","during","successive","cell","replication","or","nuclear","replication","events","."),3980382). assertion_content_comment('tOboGo_NegativeRegulationOfCellCycle',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","progression","through","the","cell","cycle","."),3970707). assertion_content_comment('tOboGo_NegativeRegulationOfCellDeath',s("Any","process","that","decreases","the","rate","or","frequency","of","cell","death",".","Cell","death","is","the","specific","activation","or","halting","of","processes","within","a","cell","so","that","its","vital","functions","markedly","cease",",","rather","than","simply","deteriorating","gradually","over","time",",","which","culminates","in","cell","death","."),3999550). assertion_content_comment('tOboGo_NegativeRegulationOfCellDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","progression","of","the","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","specific","fate","."),4006231). assertion_content_comment('tOboGo_NegativeRegulationOfCellDifferentiationInvolvedInEmbryonicPlacentaDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","cell","differentiation","that","contributes","to","the","progression","of","the","placenta","over","time",",","from","its","initial","condition","to","its","mature","state","."),4111165). assertion_content_comment('tOboGo_NegativeRegulationOfCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","differentiation","."),3989322). assertion_content_comment('tOboGo_NegativeRegulationOfCellDivision',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","division","."),4035393). assertion_content_comment('tOboGo_NegativeRegulationOfCellFateCommitment',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency","or","rate","of","cell","fate","commitment",".","Cell","fate","commitment","is","the","commitment","of","cells","to","specific","cell","fates","and","their","capacity","to","differentiate","into","particular","kinds","of","cells",".","Positional","information","is","established","through","protein","signals","that","emanate","from","a","localized","source","within","a","cell","(","the","initial","one-cell","zygote",")","or","within","a","developmental","field","."),4003474). assertion_content_comment('tOboGo_NegativeRegulationOfCellFateSpecification',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","adopting","a","specific","cell","fate","."),4003478). assertion_content_comment('tOboGo_NegativeRegulationOfCellGrowthInvolvedInCardiacMuscleCellDevelopment',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","growth","of","a","cardiac","muscle","cell",",","where","growth","contributes","to","the","progression","of","the","cell","over","time","from","its","initial","formation","to","its","mature","state","."),4113401). assertion_content_comment('tOboGo_NegativeRegulationOfCellGrowthInvolvedInContactInhibition',s("The","negative","regulation","of","cell","growth","in","response","to","increased","cell","density","."),4115355). assertion_content_comment('tOboGo_NegativeRegulationOfCellGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","growth","."),4046590). assertion_content_comment('tOboGo_NegativeRegulationOfCellKilling',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","killing","."),3984028). assertion_content_comment('tOboGo_NegativeRegulationOfCellMigrationInvolvedInSproutingAngiogenesis',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","cell","migration","involved","in","sprouting","angiogenesis",".","Cell","migration","involved","in","sprouting","angiogenesis","is","the","orderly","movement","of","endothelial","cells","into","the","extracellular","matrix","in","order","to","form","new","blood","vessels","contributing","to","the","process","of","sprouting","angiogenesis","."),4150105). assertion_content_comment('tOboGo_NegativeRegulationOfCellMigration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","migration","."),3998053). assertion_content_comment('tOboGo_NegativeRegulationOfCellMorphogenesisInvolvedInDifferentiation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","cell","morphogenesis","contributing","to","cell","differentiation",".","Cell","morphogenesis","involved","in","differentiation","is","the","change","in","form","(","cell","shape","and","size",")","that","occurs","when","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","cells",",","tissues",",","or","organs","of","the","mature","organism","or","some","other","relatively","stable","phase","of","the","organism","'","s","life","history","."),4006236). assertion_content_comment('tOboGo_NegativeRegulationOfCellMotilityInvolvedInCerebralCortexRadialGliaGuidedMigration',s("The","intracellular","signaling","pathway","that","results","in","the","cessation","of","cell","movement","involved","in","lamination","of","the","cerebral","cortex","."),4051501). assertion_content_comment('tOboGo_NegativeRegulationOfCellMotility',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","motility","."),3998047). assertion_content_comment('tOboGo_NegativeRegulationOfCellProjectionOrganization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cell","projections","."),4028554). assertion_content_comment('tOboGo_NegativeRegulationOfCellProliferationInvolvedInCompoundEyeMorphogenesis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","compound","eye","morphogenesis","."),4145587). assertion_content_comment('tOboGo_NegativeRegulationOfCellProliferationInvolvedInContactInhibition',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","cell","proliferation","in","response","to","cell","density","."),4115345). assertion_content_comment('tOboGo_NegativeRegulationOfCellProliferationInvolvedInHeartMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","heart","morphogenesis","."),4003001). assertion_content_comment('tOboGo_NegativeRegulationOfCellProliferationInvolvedInHeartValveMorphogenesis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","cell","proliferation","that","contributes","to","the","shaping","of","a","heart","valve","."),4003004). assertion_content_comment('tOboGo_NegativeRegulationOfCellProliferationInvolvedInMesonephrosDevelopment',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","mesonephros","development","."),4138203). assertion_content_comment('tOboGo_NegativeRegulationOfCellSize',s("Any","process","that","reduces","cell","size","."),4046584). assertion_content_comment('tOboGo_NegativeRegulationOfCellularAmideCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","amides","."),4066809). assertion_content_comment('tOboGo_NegativeRegulationOfCellularAmideMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amides","."),4066789). assertion_content_comment('tOboGo_NegativeRegulationOfCellularAmineCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","leading","to","the","breakdown","of","amines","."),4066901). assertion_content_comment('tOboGo_NegativeRegulationOfCellularAmineMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amines","."),4031097). assertion_content_comment('tOboGo_NegativeRegulationOfCellularAminoAcidBiosyntheticProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","cellular","amino","acid","biosynthetic","process","."),4140104). assertion_content_comment('tOboGo_NegativeRegulationOfCellularAminoAcidMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amino","acid","."),4031101). assertion_content_comment('tOboGo_NegativeRegulationOfCellularBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","substances",",","carried","out","by","individual","cells","."),3971622). assertion_content_comment('tOboGo_NegativeRegulationOfCellularCarbohydrateMetabolicProcessByRepressionOfTranscription',s("Any","cellular","process","that","decreases","the","rate",",","extent","or","frequency","of","the","chemical","reactions","and","pathways","involving","carbohydrates","carried","out","by","repression","of","transcription","."),4336417). assertion_content_comment('tOboGo_NegativeRegulationOfCellularCarbohydrateMetabolicProcess',s("Any","process","that","decreases","the","rate",",","extent","or","frequency","of","the","chemical","reactions","and","pathways","involving","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y",",","as","carried","out","by","individual","cells","."),4026563). assertion_content_comment('tOboGo_NegativeRegulationOfCellularCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","substances",",","carried","out","by","individual","cells","."),3979637). assertion_content_comment('tOboGo_NegativeRegulationOfCellularComponentMovement',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","movement","of","a","cellular","component","."),3998037). assertion_content_comment('tOboGo_NegativeRegulationOfCellularComponentOrganization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cell","structures",",","including","the","plasma","membrane","and","any","external","encapsulating","structures","such","as","the","cell","wall","and","cell","envelope","."),3975676). assertion_content_comment('tOboGo_NegativeRegulationOfCellularDefenseResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","the","cellular","defense","response","."),4120047). assertion_content_comment('tOboGo_NegativeRegulationOfCellularExtravasation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","cellular","extravasation","."),3998100). assertion_content_comment('tOboGo_NegativeRegulationOfCellularMacromoleculeBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cellular","macromolecule","biosynthetic","process","."),3971634). assertion_content_comment('tOboGo_NegativeRegulationOfCellularMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","by","which","individual","cells","transform","chemical","substances","."),3971528). assertion_content_comment('tOboGo_NegativeRegulationOfCellularOrganofluorineMetabolicProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","involving","organofluorine","compounds",",","as","carried","out","by","individual","cells","."),4151094). assertion_content_comment('tOboGo_NegativeRegulationOfCellularOrganohalogenMetabolicProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","involving","organohalogen","compounds",",","as","carried","out","by","individual","cells","."),4151083). assertion_content_comment('tOboGo_NegativeRegulationOfCellularPHReduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","process","that","reduces","the","internal","pH","of","a","cell","."),4070068). assertion_content_comment('tOboGo_NegativeRegulationOfCellularProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","cellular","process",",","any","of","those","that","are","carried","out","at","the","cellular","level",",","but","are","not","necessarily","restricted","to","a","single","cell",".","For","example",",","cell","communication","occurs","among","more","than","one","cell",",","but","occurs","at","the","cellular","level","."),3970677). assertion_content_comment('tOboGo_NegativeRegulationOfCellularProteinMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","protein",",","occurring","at","the","level","of","an","individual","cell","."),3975725). assertion_content_comment('tOboGo_NegativeRegulationOfCellularResponseToGrowthFactorStimulus',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","a","change","in","state","or","activity","of","a","cell","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","growth","factor","stimulus","."),4145321). assertion_content_comment('tOboGo_NegativeRegulationOfCellularResponseToNitrogenStarvation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","cellular","response","to","nitrogen","starvation","."),4030048). assertion_content_comment('tOboGo_NegativeRegulationOfCellVolume',s("Any","process","that","decreases","cell","volume","."),4297768). assertion_content_comment('tOboGo_NegativeRegulationOfCentralBCellAnergy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","central","B","cell","anergy","."),3999881). assertion_content_comment('tOboGo_NegativeRegulationOfCentralBCellDeletion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","central","B","cell","deletion","."),3999682). assertion_content_comment('tOboGo_NegativeRegulationOfCentralBCellToleranceInduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","central","B","cell","tolerance","induction","."),3999631). assertion_content_comment('tOboGo_NegativeRegulationOfCentralToleranceInduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","central","tolerance","induction","."),3995463). assertion_content_comment('tOboGo_NegativeRegulationOfCentrioleReplication',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","centriole","replication","."),4098762). assertion_content_comment('tOboGo_NegativeRegulationOfCentrosomeCycle',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","centrosome","cycle","."),4098660). assertion_content_comment('tOboGo_NegativeRegulationOfCentrosomeDuplication',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","centrosome","duplication",".","Centrosome","duplication","is","the","replication","of","a","centrosome",",","a","structure","comprised","of","a","pair","of","centrioles","and","peri-centriolar","material","from","which","a","microtubule","spindle","apparatus","is","organized","."),4036472). assertion_content_comment('tOboGo_NegativeRegulationOfCerebellarGranuleCellPrecursorProliferation',s("The","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","granule","cell","precursor","proliferation","."),4047905). assertion_content_comment('tOboGo_NegativeRegulationOfCGMPBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cGMP","."),4050781). assertion_content_comment('tOboGo_NegativeRegulationOfCGMPCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cGMP","."),4050964). assertion_content_comment('tOboGo_NegativeRegulationOfCGMPMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","cGMP","."),4050595). assertion_content_comment('tOboGo_NegativeRegulationOfChemokineBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","chemokines","."),4097057). assertion_content_comment('tOboGo_NegativeRegulationOfChemokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","chemokine","production","."),4068532). assertion_content_comment('tOboGo_NegativeRegulationOfChemokineSecretion',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","chemokine","secretion",",","the","regulated","release","of","chemokines","from","a","cell","or","group","of","cells","."),4084127). assertion_content_comment('tOboGo_NegativeRegulationOfChemotaxis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","."),3998157). assertion_content_comment('tOboGo_NegativeRegulationOfCholesterolBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cholesterol","."),4088814). assertion_content_comment('tOboGo_NegativeRegulationOfCholesterolEfflux',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","cholesterol","efflux",".","Cholesterol","efflux","is","the","directed","movement","of","cholesterol",",","cholest-5-en-3-beta-ol",",","out","of","a","cell","or","organelle","."),4151305). assertion_content_comment('tOboGo_NegativeRegulationOfCholesterolImport',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","cholesterol","import",".","Cholesterol","import","is","the","directed","movement","of","cholesterol","into","a","cell","or","organelle","."),4111671). assertion_content_comment('tOboGo_NegativeRegulationOfCholesterolMetabolicProcess',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","cholesterol","metabolism",",","the","chemical","reactions","and","pathways","involving","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4088811). assertion_content_comment('tOboGo_NegativeRegulationOfCholesterolStorage',s("Any","process","that","decreases","the","rate","or","extent","of","cholesterol","storage",".","Cholesterol","storage","is","the","accumulation","and","maintenance","in","cells","or","tissues","of","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4037539). assertion_content_comment('tOboGo_NegativeRegulationOfCholesterolTransporterActivity',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","cholesterol","transporter","activity","."),4160917). assertion_content_comment('tOboGo_NegativeRegulationOfCholesterolTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","cholesterol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4056596). assertion_content_comment('tOboGo_NegativeRegulationOfChondrocyteDevelopment',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","process","whose","specific","outcome","is","the","progression","of","a","chondrocyte","over","time",",","from","its","commitment","to","its","mature","state",".","Chondrocyte","development","does","not","include","the","steps","involved","in","committing","a","chondroblast","to","a","chondrocyte","fate","."),4135907). assertion_content_comment('tOboGo_NegativeRegulationOfChromatinAssemblyOrDisassembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","chromatin","assembly","or","disassembly","."),4058354). assertion_content_comment('tOboGo_NegativeRegulationOfChromatinBinding',s("Any","process","that","stops","or","reduces","the","frequency",",","rate","or","extent","of","chromatin","binding",".","Chromatin","binding","is","the","selective","interaction","with","chromatin",",","the","network","of","fibers","of","DNA","and","protein","that","make","up","the","chromosomes","of","the","eukaryotic","nucleus","during","interphase","."),4378537). assertion_content_comment('tOboGo_NegativeRegulationOfChromatinSilencingAtRDNA',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","repression","of","transcription","of","ribosomal","DNA","by","altering","the","structure","of","chromatin","."),4136140). assertion_content_comment('tOboGo_NegativeRegulationOfChromatinSilencingAtTelomere',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","chromatin","silencing","at","telomeres","."),4057703). assertion_content_comment('tOboGo_NegativeRegulationOfChromatinSilencingBySmallRNA',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","chromatin","silencing","by","small","RNA",".","Chromatin","silencing","by","small","RNA","is","the","repression","of","transcription","by","conversion","of","large","regions","of","DNA","into","heterochromatin",",","directed","by","small","RNAs","sharing","sequence","identity","to","the","repressed","region","."),4114228). assertion_content_comment('tOboGo_NegativeRegulationOfChromatinSilencing',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","chromatin","silencing","."),4057694). assertion_content_comment('tOboGo_NegativeRegulationOfChromosomeSegregation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","chromosome","segregation",",","the","process","in","which","genetic","material",",","in","the","form","of","chromosomes",",","is","organized","and","then","physically","separated","and","apportioned","to","two","or","more","sets","."),4064986). assertion_content_comment('tOboGo_NegativeRegulationOfChronicInflammatoryResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","chronic","inflammatory","response","."),3998430). assertion_content_comment('tOboGo_NegativeRegulationOfChronicInflammatoryResponseToAntigenicStimulus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","chronic","inflammatory","response","to","an","antigenic","stimulus","."),4000640). assertion_content_comment('tOboGo_NegativeRegulationOfCiliumMovement',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","cilium","movement",",","the","directed",",","self-propelled","movement","of","a","cilium","."),4005858). assertion_content_comment('tOboGo_NegativeRegulationOfCircadianRhythm',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","circadian","rhythm","behavior","."),4077347). assertion_content_comment('tOboGo_NegativeRegulationOfCircadianSleepWakeCycleREMSleep',s("Any","process","that","stops",",","prevents","or","reduces","the","duration","or","quality","of","rapid","eye","movement","(","REM",")","sleep","."),4079676). assertion_content_comment('tOboGo_NegativeRegulationOfCircadianSleepWakeCycleSleep',s("Any","process","that","stops",",","prevents","or","reduces","the","duration","or","quality","of","sleep",",","a","readily","reversible","state","of","reduced","awareness","and","metabolic","activity","that","occurs","periodically","in","many","animals","."),4079668). assertion_content_comment('tOboGo_NegativeRegulationOfCleistotheciumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cleistothecium","development",",","a","process","that","leads","to","the","formation","of","a","cleistothecium",".","The","cleistothecium","is","a","closed","sexual","fruiting","body","that","contains","ascospores","in","linear","asci",",","characteristic","of","some","filamentous","Ascomycete","fungi","such","as","members","of","the","genera","Aspergillus","and","Emericella","."),4132732). assertion_content_comment('tOboGo_NegativeRegulationOfCoagulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","coagulation","."),4027262). assertion_content_comment('tOboGo_NegativeRegulationOfCoenzymeAndProstheticGroupMetabolicProcess',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","coenzymes","and","prosthetic","groups","."),4351911). assertion_content_comment('tOboGo_NegativeRegulationOfCoenzymeMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","coenzyme","."),4119662). assertion_content_comment('tOboGo_NegativeRegulationOfCofactorMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","cofactor","."),4119581). assertion_content_comment('tOboGo_NegativeRegulationOfCohesinLocalizationToChromatin',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","process","in","which","a","cohesin","complex","is","transported","to",",","or","maintained","at",",","a","part","of","a","chromosome","that","is","organized","into","chromatin","."),4125914). assertion_content_comment('tOboGo_NegativeRegulationOfCollagenBinding',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","collagen","binding","."),4338664). assertion_content_comment('tOboGo_NegativeRegulationOfCollagenCatabolicProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","collagen","catabolism",".","Collagen","catabolism","is","the","proteolytic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","collagen","in","the","extracellular","matrix","."),4026956). assertion_content_comment('tOboGo_NegativeRegulationOfCollagenMetabolicProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","metabolism","of","collagen",",","any","of","a","group","of","fibrous","proteins","of","very","high","tensile","strength","that","form","the","main","component","of","connective","tissue","in","animals","."),4026896). assertion_content_comment('tOboGo_NegativeRegulationOfCollateralSproutingInAbsenceOfInjury',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","collateral","sprouting","in","the","absence","of","injury","."),4107165). assertion_content_comment('tOboGo_NegativeRegulationOfCollateralSproutingOfInjuredAxon',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","collateral","sprouting","of","an","injured","axon","."),4107002). assertion_content_comment('tOboGo_NegativeRegulationOfCollateralSproutingOfIntactAxonInResponseToInjury',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","collateral","sprouting","of","an","intact","axon","as","a","result","of","injury","to","an","axon","."),4106873). assertion_content_comment('tOboGo_NegativeRegulationOfCollateralSprouting',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","collateral","sprouting","."),4106806). assertion_content_comment('tOboGo_NegativeRegulationOfComplementActivationAlternativePathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","complement","activation","by","the","alternative","pathway","."),4092592). assertion_content_comment('tOboGo_NegativeRegulationOfComplementActivationClassicalPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","complement","activation","by","the","classical","pathway","."),4092557). assertion_content_comment('tOboGo_NegativeRegulationOfComplementActivationLectinPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","complement","activation","by","the","lectin","pathway","."),3986376). assertion_content_comment('tOboGo_NegativeRegulationOfComplementActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","complement","activation","."),3986368). assertion_content_comment('tOboGo_NegativeRegulationOfCompoundEyeConeCellFateSpecification',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","specifying","into","a","compound","eye","cone","cell","."),4078014). assertion_content_comment('tOboGo_NegativeRegulationOfCompoundEyePhotoreceptorDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","compound","eye","photoreceptor","development","."),4085776). assertion_content_comment('tOboGo_NegativeRegulationOfCompoundEyePigmentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","compound","eye","."),4104251). assertion_content_comment('tOboGo_NegativeRegulationOfCompoundEyeRetinalCellProgrammedCellDeath',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","programmed","cell","death","that","occurs","in","the","compound","eye","retina","."),4099160). assertion_content_comment('tOboGo_NegativeRegulationOfConidiophoreDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","conidiophore","development",",","a","process","that","leads","to","the","formation","of","a","conidiophore",".","The","conidiophore","is","a","specialized","hypha","that","extends","aerially","from","the","growth","substrate","and","bears","conidia",",","or","asexual","spores","."),4132710). assertion_content_comment('tOboGo_NegativeRegulationOfConidiophoreStalkDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","conidiophore","stalk","development",",","a","process","that","leads","to","the","formation","of","a","conidiophore","stalk",".","The","conidiophore","stalk","is","part","of","a","specialized","hypha","that","extends","aerially","from","the","growth","substrate","and","supports","structures","from","which","conidia",",","or","asexual","spores",",","develop","."),4132524). assertion_content_comment('tOboGo_NegativeRegulationOfConidiumFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","conidium","formation",",","a","processes","leading","to","the","production","of","a","type","of","asexual","non-motile","reproductive","spore","of","fungi","via","mitosis","at","the","tip","or","side","of","hyphae","or","on","special","spore-producing","structures","called","conidiophores","."),4148073). assertion_content_comment('tOboGo_NegativeRegulationOfConjugation',s("Any","process","that","decreases","the","rate","of","conjugation","."),4029950). assertion_content_comment('tOboGo_NegativeRegulationOfConjugationWithCellularFusion',s("Any","process","that","decreases","the","rate","or","frequency","of","conjugation","with","cellular","fusion","."),4029958). assertion_content_comment('tOboGo_NegativeRegulationOfConnectiveTissueGrowthFactorBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","connective","tissue","growth","factor","."),4089019). assertion_content_comment('tOboGo_NegativeRegulationOfConnectiveTissueGrowthFactorProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","connective","tissue","growth","factor","production","."),4068554). assertion_content_comment('tOboGo_NegativeRegulationOfCoreceptorActivityInvolvedInEpidermalGrowthFactorReceptorSignalingPathway',s("Any","process","that","decreases","the","rate","or","frequency","of","coreceptor","activity","involved","in","epidermal","growth","factor","receptor","signaling","pathway","."),4161157). assertion_content_comment('tOboGo_NegativeRegulationOfCorticotropinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","corticotropic","hormone","from","a","cell","or","group","of","cells","."),4118488). assertion_content_comment('tOboGo_NegativeRegulationOfCortisolBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cortisol","biosynthetic","process","."),4138867). assertion_content_comment('tOboGo_NegativeRegulationOfCortisolSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","cortisol","from","a","cell","or","group","of","cells","."),4118509). assertion_content_comment('tOboGo_NegativeRegulationOfCREBTranscriptionFactorActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","activity","of","the","transcription","factor","CREB","."),4337687). assertion_content_comment('tOboGo_NegativeRegulationOfCrystalCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","crystal","cell","differentiation","."),4078049). assertion_content_comment('tOboGo_NegativeRegulationOfCrystalFormation',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","spontaneous","(","nonenzymatic",")","formation","of","crystals","in","a","solution",",","for","example",",","calcium","oxalate","crystals","in","urine","."),4358616). assertion_content_comment('tOboGo_NegativeRegulationOfCumulusCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ovarian","cumulus","cell","differentiation","."),4088385). assertion_content_comment('tOboGo_NegativeRegulationOfCuticlePigmentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","cuticle","of","an","organism","."),4104140). assertion_content_comment('tOboGo_NegativeRegulationOfCyanophoreDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cyanophore","differentiation","."),4104869). assertion_content_comment('tOboGo_NegativeRegulationOfCyclaseActivity',s("Any","process","that","stops","or","reduces","the","activity","of","a","cyclase","."),4152940). assertion_content_comment('tOboGo_NegativeRegulationOfCyclicNucleotideBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cyclic","nucleotides","."),4049840). assertion_content_comment('tOboGo_NegativeRegulationOfCyclicNucleotideCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cyclic","nucleotides","."),4050467). assertion_content_comment('tOboGo_NegativeRegulationOfCyclicNucleotideMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","cyclic","nucleotides","."),4049809). assertion_content_comment('tOboGo_NegativeRegulationOfCyclinCatabolicProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","cyclin","catabolic","process","."),4143837). assertion_content_comment('tOboGo_NegativeRegulationOfCytokineActivity',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","activity","of","a","molecule","that","controls","the","survival",",","growth",",","differentiation","and","effector","function","of","tissues","and","cells","."),4160574). assertion_content_comment('tOboGo_NegativeRegulationOfCytokineBiosyntheticProcessInvolvedInImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","cytokine","biosynthesis","contributing","to","an","immune","response","."),3996905). assertion_content_comment('tOboGo_NegativeRegulationOfCytokineBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cytokines","."),3996894). assertion_content_comment('tOboGo_NegativeRegulationOfCytokineProductionInvolvedInImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","cytokine","production","contributing","to","an","immune","response","."),3997239). assertion_content_comment('tOboGo_NegativeRegulationOfCytokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","production","of","a","cytokine","."),3984419). assertion_content_comment('tOboGo_NegativeRegulationOfCytokineSecretionInvolvedInImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","cytokine","secretion","contributing","to","an","immune","response","."),3997120). assertion_content_comment('tOboGo_NegativeRegulationOfCytokineSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","cytokines","from","a","cell","or","group","of","cells","."),3997113). assertion_content_comment('tOboGo_NegativeRegulationOfCytokinesisActomyosinContractileRingAssembly',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","cytokinesis",",","actomyosin","contractile","ring","assembly","."),4142084). assertion_content_comment('tOboGo_NegativeRegulationOfCytokinesisByBinaryFission',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cytokinesis","by","binary","fission","."),4140514). assertion_content_comment('tOboGo_NegativeRegulationOfCytokinesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cytokinesis","."),4035400). assertion_content_comment('tOboGo_NegativeRegulationOfCytokininMediatedSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","cytokinin","."),4148749). assertion_content_comment('tOboGo_NegativeRegulationOfCytolysisBySymbiontOfHostCells',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cytolysis","by","that","organism","of","cells","in","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3986048). assertion_content_comment('tOboGo_NegativeRegulationOfCytolysisInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cytolysis","by","that","organism","of","cells","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3986039). assertion_content_comment('tOboGo_NegativeRegulationOfCytolysisInOtherOrganism',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","cytolysis","of","cells","in","another","organism","."),3986029). assertion_content_comment('tOboGo_NegativeRegulationOfCytolysis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cytolysis","."),4089732). assertion_content_comment('tOboGo_NegativeRegulationOfCytoplasmicMRNAProcessingBodyAssembly',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","aggregation",",","arrangement","and","bonding","together","of","proteins","and","RNA","molecules","to","form","a","cytoplasmic","mRNA","processing","body","."),4028229). assertion_content_comment('tOboGo_NegativeRegulationOfCytoskeletonOrganization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","."),4013268). assertion_content_comment('tOboGo_NegativeRegulationOfCytoskeleton',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","organization",",","biogenesis","or","maintenance","of","the","cytoskeleton","."),4297750). assertion_content_comment('tOboGo_NegativeRegulationOfCytotoxicTCellDegranulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","cytotoxic","T","cell","degranulation","."),4095588). assertion_content_comment('tOboGo_NegativeRegulationOfCytotoxicTCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cytotoxic","T","cell","differentiation","."),4088470). assertion_content_comment('tOboGo_NegativeRegulationOfDauerLarvalDevelopment',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","dauer","larval","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","dauer","larva","over","time",",","through","the","facultative","diapause","of","the","dauer","(","enduring",")","larval","stage",",","with","specialized","traits","adapted","for","dispersal","and","long-term","survival",",","with","elevated","stress","resistance","and","without","feeding","."),4113547). assertion_content_comment('tOboGo_NegativeRegulationOfDecapentaplegicReceptorSignalingPathway',s("Any","process","that","decreases","the","frequency",",","rate",",","or","extent","of","the","decapentaplegic","receptor","signaling","pathway",".","The","decapentaplegic","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","a","decapentaplegic","receptor","binding","to","one","of","its","physiological","ligands","."),4150428). assertion_content_comment('tOboGo_NegativeRegulationOfDefecation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","defecation","."),4140028). assertion_content_comment('tOboGo_NegativeRegulationOfDefenseResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","defense","response","."),3983769). assertion_content_comment('tOboGo_NegativeRegulationOfDefenseResponseToVirusByHost',s("Any","host","process","that","results","in","the","inhibition","of","antiviral","immune","response","mechanisms",",","thereby","facilitating","viral","replication",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4277193). assertion_content_comment('tOboGo_NegativeRegulationOfDefenseResponseToVirus',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","antiviral","mechanisms",",","thereby","facilitating","viral","replication","."),4101394). assertion_content_comment('tOboGo_NegativeRegulationOfDendriteDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","dendrite","development","."),4141596). assertion_content_comment('tOboGo_NegativeRegulationOfDendriteMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","dendrite","morphogenesis","."),4101002). assertion_content_comment('tOboGo_NegativeRegulationOfDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","dendritic","cell","antigen","processing","and","presentation","."),3994701). assertion_content_comment('tOboGo_NegativeRegulationOfDendriticCellChemotaxis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","dendritic","cell","chemotaxis","."),4144680). assertion_content_comment('tOboGo_NegativeRegulationOfDendriticCellCytokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","dendritic","cell","cytokine","production","."),3997248). assertion_content_comment('tOboGo_NegativeRegulationOfDendriticCellDendriteAssembly',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","dendritic","cell","dendrite","assembly","."),4145015). assertion_content_comment('tOboGo_NegativeRegulationOfDendriticSpineDevelopment',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","dendritic","spine","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","dendritic","spine","over","time",",","from","its","formation","to","the","mature","structure","."),4113118). assertion_content_comment('tOboGo_NegativeRegulationOfDendriticSpineMorphogenesis',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","dendritic","spine","morphogenesis",",","the","process","in","which","the","anatomical","structures","of","a","dendritic","spine","are","generated","and","organized",".","A","dendritic","spine","is","a","protrusion","from","a","dendrite","and","a","specialized","subcellular","compartment","involved","in","synaptic","transmission","."),4113133). assertion_content_comment('tOboGo_NegativeRegulationOfDeoxyribonucleaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","deoxyribonuclease","activity",",","the","hydrolysis","of","ester","linkages","within","deoxyribonucleic","acid","."),4330549). assertion_content_comment('tOboGo_NegativeRegulationOfDephosphorylation',s("Any","process","the","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","removal","of","phosphate","groups","from","a","molecule","."),4071123). assertion_content_comment('tOboGo_NegativeRegulationOfDermatomeDevelopment',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","progression","of","the","dermatome","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","dermatome","is","the","portion","of","a","somite","that","will","form","skin","."),4136107). assertion_content_comment('tOboGo_NegativeRegulationOfDeterminationOfDorsalIdentity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","determination","of","dorsal","identity","."),4139459). assertion_content_comment('tOboGo_NegativeRegulationOfDevelopmentalGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","developmental","growth","."),4046631). assertion_content_comment('tOboGo_NegativeRegulationOfDevelopmentalPigmentation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","developmental","process","that","results","in","the","deposition","of","coloring","matter","in","an","organism","."),4087030). assertion_content_comment('tOboGo_NegativeRegulationOfDevelopmentalProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","development",",","the","biological","process","whose","specific","outcome","is","the","progression","of","an","organism","over","time","from","an","initial","condition","(","e.g",".","a","zygote",",","or","a","young","adult",")","to","a","later","condition","(","e.g",".","a","multicellular","animal","or","an","aged","adult",")"),3989316). assertion_content_comment('tOboGo_NegativeRegulationOfDevelopmentHeterochronic',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","progression","an","integrated","living","unit",":","an","anatomical","structure","(","which","may","be","a","subcellular","structure",",","cell",",","tissue",",","or","organ",")",",","or","organism","over","time","from","an","initial","condition","to","a","later","condition","at","a","consistent","predetermined","time","point","during","its","development","."),4297963). assertion_content_comment('tOboGo_NegativeRegulationOfDevelopmentOfSymbiontInHost',s("Any","process","in","which","the","symbiont","stops",",","prevents","or","reduces","its","progression","from","an","initial","condition","to","a","later","condition",",","within","the","cells","or","tissues","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4097817). assertion_content_comment('tOboGo_NegativeRegulationOfDevelopmentOfSymbiontInvolvedInInteractionWithHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","progression","of","an","organism","from","an","initial","condition","to","a","later","condition",",","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4097611). assertion_content_comment('tOboGo_NegativeRegulationOfDevelopmentOfSymbiontOnOrNearHostSurface',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","symbiont","'","s","progression","from","an","initial","condition","to","a","later","condition",",","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4097615). assertion_content_comment('tOboGo_NegativeRegulationOfDigestiveSystemProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","a","digestive","system","process",",","a","physical",",","chemical",",","or","biochemical","process","carried","out","by","living","organisms","to","break","down","ingested","nutrients","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),4035349). assertion_content_comment('tOboGo_NegativeRegulationOfDiuresis',s("OBSOLETE",".","Any","process","that","reduces","the","rate","of","diuresis",".","Diuresis","is","the","process","of","renal","water","excretion","."),4193948). assertion_content_comment('tOboGo_NegativeRegulationOfDNABinding',s("Any","process","that","stops","or","reduces","the","frequency",",","rate","or","extent","of","DNA","binding",".","DNA","binding","is","any","process","in","which","a","gene","product","interacts","selectively","with","DNA","(","deoxyribonucleic","acid",")"),4172514). assertion_content_comment('tOboGo_NegativeRegulationOfDNABiosyntheticProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","DNA","biosynthetic","process","."),4140167). assertion_content_comment('tOboGo_NegativeRegulationOfDNADamageCheckpoint',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","DNA","damage","checkpoint","."),4139590). assertion_content_comment('tOboGo_NegativeRegulationOfDNADamageResponseSignalTransductionByP53ClassMediator',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","cascade","of","processes","induced","by","the","cell","cycle","regulator","phosphoprotein","p53",",","or","an","equivalent","protein",",","in","response","to","the","detection","of","DNA","damage","."),4094564). assertion_content_comment('tOboGo_NegativeRegulationOfDNAEndoreduplication',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","DNA","endoreduplication","."),4064822). assertion_content_comment('tOboGo_NegativeRegulationOfDNALigation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","DNA","ligation",",","the","re-formation","of","a","broken","phosphodiester","bond","in","the","DNA","backbone",",","carried","out","by","DNA","ligase","."),4119473). assertion_content_comment('tOboGo_NegativeRegulationOfDNAMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","DNA","."),3975186). assertion_content_comment('tOboGo_NegativeRegulationOfDNARecombinationAtTelomere',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","genetic","recombination","within","the","telomere","."),4384864). assertion_content_comment('tOboGo_NegativeRegulationOfDNARecombination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","DNA","recombination","."),3975194). assertion_content_comment('tOboGo_NegativeRegulationOfDNARepair',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","DNA","repair","."),4055680). assertion_content_comment('tOboGo_NegativeRegulationOfDNAReplicationInitiationInvolvedInPlasmidCopyNumberMaintenance',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","initiation","of","plasmid","DNA","replication","that","contributes","to","copy","number","maintenance","."),4156926). assertion_content_comment('tOboGo_NegativeRegulationOfDNAReplication',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","DNA","replication","."),4016077). assertion_content_comment('tOboGo_NegativeRegulationOfDopamineMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","dopamine","."),4092608). assertion_content_comment('tOboGo_NegativeRegulationOfDopamineReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","dopamine","receptor","protein","signaling","pathway","activity",".","A","dopamine","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","a","dopamine","receptor","binding","to","one","of","its","physiological","ligands","."),4108351). assertion_content_comment('tOboGo_NegativeRegulationOfDopamineSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","dopamine","."),4063456). assertion_content_comment('tOboGo_NegativeRegulationOfDopamineUptake',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","dopamine","into","a","cell","."),4121292). assertion_content_comment('tOboGo_NegativeRegulationOfEarlyEndosomeToLateEndosomeTransport',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","early","endosome","to","late","endosome","transport","."),4137645). assertion_content_comment('tOboGo_NegativeRegulationOfEarlyStripeMelanocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","early","stripe","melanocyte","differentiation","."),4100064). assertion_content_comment('tOboGo_NegativeRegulationOfEcdysteroidBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","ecdysteroids","."),4092115). assertion_content_comment('tOboGo_NegativeRegulationOfEcdysteroidMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","ecdysteroids","."),4092106). assertion_content_comment('tOboGo_NegativeRegulationOfEcdysteroidSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","ecdysteroid","."),4092150). assertion_content_comment('tOboGo_NegativeRegulationOfEclosion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","eclosion","."),4090905). assertion_content_comment('tOboGo_NegativeRegulationOfEctodermalCellFateSpecification',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","specifying","into","an","ectoderm","cell","."),4078172). assertion_content_comment('tOboGo_NegativeRegulationOfEctodermDevelopment',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","ectoderm","development","."),4142532). assertion_content_comment('tOboGo_NegativeRegulationOfElastinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","elastin","."),4118823). assertion_content_comment('tOboGo_NegativeRegulationOfElastinCatabolicProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","elastin","catabolism",",","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","elastin","."),4114880). assertion_content_comment('tOboGo_NegativeRegulationOfEmbryonicDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","embryonic","development","."),4092234). assertion_content_comment('tOboGo_NegativeRegulationOfEmbryoSacCentralCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","embryo","sac","central","cell","differentiation","."),4091571). assertion_content_comment('tOboGo_NegativeRegulationOfEmbryoSacEggCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","embryo","sac","egg","cell","differentiation","."),4091711). assertion_content_comment('tOboGo_NegativeRegulationOfEnamelMineralization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","enamel","mineralization",",","the","deposition","of","calcium","salts","in","tooth","enamel","."),4133451). assertion_content_comment('tOboGo_NegativeRegulationOfEncystedZoosporeGerminationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","encysted","zoospore","germination","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146512). assertion_content_comment('tOboGo_NegativeRegulationOfEndocytosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","endocytosis","."),3989902). assertion_content_comment('tOboGo_NegativeRegulationOfEndodeoxyribonucleaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","endodeoxyribonuclease","activity",",","the","hydrolysis","of","ester","linkages","within","deoxyribonucleic","acid","by","creating","internal","breaks","."),4330557). assertion_content_comment('tOboGo_NegativeRegulationOfEndodermalCellFateSpecification',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","specifying","into","an","endoderm","cell","."),4078131). assertion_content_comment('tOboGo_NegativeRegulationOfEndopeptidaseActivity',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","endopeptidase","activity",",","the","endohydrolysis","of","peptide","bonds","within","proteins","."),4170378). assertion_content_comment('tOboGo_NegativeRegulationOfEndoribonucleaseActivity',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","catalysis","of","the","hydrolysis","of","ester","linkages","within","ribonucleic","acid","by","creating","internal","breaks","."),4161258). assertion_content_comment('tOboGo_NegativeRegulationOfEndothelialCellApoptosis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","endothelial","cell","apoptosis","."),4143477). assertion_content_comment('tOboGo_NegativeRegulationOfEndothelialCellChemotaxisToFibroblastGrowthFactor',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","endothelial","cell","chemotaxis","to","fibroblast","growth","factor","."),4145325). assertion_content_comment('tOboGo_NegativeRegulationOfEndothelialCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","endothelial","cell","differentiation","."),4088369). assertion_content_comment('tOboGo_NegativeRegulationOfEndothelialCellMigration',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","orderly","movement","of","an","endothelial","cell","into","the","extracellular","matrix","to","form","an","endothelium","."),4028193). assertion_content_comment('tOboGo_NegativeRegulationOfEndothelialCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","or","extent","of","endothelial","cell","proliferation","."),3988563). assertion_content_comment('tOboGo_NegativeRegulationOfEndothelialMicroparticleFormation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","endothelial","microparticle","formation","."),4143209). assertion_content_comment('tOboGo_NegativeRegulationOfEnergyHomeostasis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","energy","homeostasis","."),4145741). assertion_content_comment('tOboGo_NegativeRegulationOfEntryOfBacteriumIntoHostCell',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","entry","of","bacterium","into","host","cell","."),4145127). assertion_content_comment('tOboGo_NegativeRegulationOfEosinophilChemotaxis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","eosinophil","chemotaxis","."),4141912). assertion_content_comment('tOboGo_NegativeRegulationOfEosinophilDegranulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","eosinophil","degranulation","."),4093501). assertion_content_comment('tOboGo_NegativeRegulationOfEosinophilDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","eosinophil","differentiation","."),4087642). assertion_content_comment('tOboGo_NegativeRegulationOfEosinophilExtravasation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","eosinophil","extravasation","."),4141888). assertion_content_comment('tOboGo_NegativeRegulationOfEosinophilMigration',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","eosinophil","migration","."),4141884). assertion_content_comment('tOboGo_NegativeRegulationOfEpidermalCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","epidermal","cell","differentiation","."),4087079). assertion_content_comment('tOboGo_NegativeRegulationOfEpidermalGrowthFactorReceptorActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","EGF","receptor","activity","."),4217379). assertion_content_comment('tOboGo_NegativeRegulationOfEpidermalGrowthFactorReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","epidermal","growth","factor","receptor","signaling","pathway","activity","."),4081596). assertion_content_comment('tOboGo_NegativeRegulationOfEpidermisDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","epidermis","development","."),4087070). assertion_content_comment('tOboGo_NegativeRegulationOfEpinephrineSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","epinephrine","."),4070353). assertion_content_comment('tOboGo_NegativeRegulationOfEpinephrineUptake',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","epinephrine","into","a","cell","."),4121544). assertion_content_comment('tOboGo_NegativeRegulationOfEpithelialCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","epithelial","cell","differentiation","."),4061694). assertion_content_comment('tOboGo_NegativeRegulationOfEpithelialCellMigration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","epithelial","cell","migration","."),4028683). assertion_content_comment('tOboGo_NegativeRegulationOfEpithelialCellProliferationInvolvedInProstateGlandDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","epithelial","cell","proliferation","that","contributes","to","the","progression","of","the","prostate","gland","over","time","."),4110983). assertion_content_comment('tOboGo_NegativeRegulationOfEpithelialCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","epithelial","cell","proliferation","."),3988556). assertion_content_comment('tOboGo_NegativeRegulationOfEpithelialToMesenchymalTransition',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","epithelial","to","mesenchymal","transition",".","Epithelial","to","mesenchymal","transition","where","an","epithelial","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","."),4027052). assertion_content_comment('tOboGo_NegativeRegulationOfErgosterolBiosyntheticProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","ergosterol","."),4037848). assertion_content_comment('tOboGo_NegativeRegulationOfERK1AndERK2Cascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","ERK1","and","ERK2","cascade","."),4136862). assertion_content_comment('tOboGo_NegativeRegulationOfErythrocyteAggregation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","erythrocyte","aggregation","."),4076838). assertion_content_comment('tOboGo_NegativeRegulationOfErythrocyteClearance',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","erythrocyte","clearance","."),4076666). assertion_content_comment('tOboGo_NegativeRegulationOfErythrocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","erythrocyte","differentiation","."),4087657). assertion_content_comment('tOboGo_NegativeRegulationOfErythrophoreDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","erythrophore","differentiation","."),4105070). assertion_content_comment('tOboGo_NegativeRegulationOfEstablishmentOfCompetenceForTransformation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","of","competence","for","transformation","."),4090484). assertion_content_comment('tOboGo_NegativeRegulationOfEstablishmentOfContractileRingLocalizationInvolvedInCellCycleCytokinesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","process","in","which","a","contractile","ring","is","assembled","in","a","specific","location","."),4128395). assertion_content_comment('tOboGo_NegativeRegulationOfEstablishmentOfProteinLocalizationInPlasmaMembrane',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","protein","to","a","specific","location","in","the","plasma","membrane","."),4149583). assertion_content_comment('tOboGo_NegativeRegulationOfEstablishmentOfTurgorInAppressorium',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","turgor","formation","in","the","symbiont","appressorium","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147027). assertion_content_comment('tOboGo_NegativeRegulationOfEstablishmentOrMaintenanceOfNeuroblastPolarity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","or","maintenance","of","neuroblast","polarity","."),4140462). assertion_content_comment('tOboGo_NegativeRegulationOfEstrogenReceptorBinding',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","estrogen","receptor","binding",",","interacting","selectively","with","an","estrogen","receptor","."),4170640). assertion_content_comment('tOboGo_NegativeRegulationOfEstrogenReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","activity","of","an","estrogen","receptor","signaling","pathway","."),4065618). assertion_content_comment('tOboGo_NegativeRegulationOfEthyleneBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","an","ethylene","biosynthetic","process","."),4031137). assertion_content_comment('tOboGo_NegativeRegulationOfEthyleneMediatedSignalingPathway',s("Any","process","that","stops","or","prevents","ethylene","(","ethene",")","mediated","signaling","."),4033098). assertion_content_comment('tOboGo_NegativeRegulationOfEukaryoticCellSurfaceBinding',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","eukaryotic","cell","surface","binding","."),4171944). assertion_content_comment('tOboGo_NegativeRegulationOfExcitatoryPostsynapticMembranePotential',s("Any","process","that","prevents","the","establishment","or","decreases","the","extent","of","the","excitatory","postsynaptic","potential","(","EPSP",")","which","is","a","temporary","increase","in","postsynaptic","potential","due","to","the","flow","of","positively","charged","ions","into","the","postsynaptic","cell",".","The","flow","of","ions","that","causes","an","EPSP","is","an","excitatory","postsynaptic","current","(","EPSC",")","and","makes","it","easier","for","the","neuron","to","fire","an","action","potential","."),4155213). assertion_content_comment('tOboGo_NegativeRegulationOfExitFromMitosis',s("Any","process","involved","in","the","inhibition","of","progression","from","anaphase/telophase","(","high","mitotic","CDK","activity",")","to","G1","(","low","mitotic","CDK","activity",")"),3980385). assertion_content_comment('tOboGo_NegativeRegulationOfExocystAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","or","extent","of","exocyst","assembly","."),3988909). assertion_content_comment('tOboGo_NegativeRegulationOfExocytosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","exocytosis","."),4089699). assertion_content_comment('tOboGo_NegativeRegulationOfExogen',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","exogen",",","the","shedding","phase","of","the","hair","cycle","."),4122455). assertion_content_comment('tOboGo_NegativeRegulationOfExtentOfHeterochromatinFormation',s("Any","process","that","reduces","the","extent","of","heterochromatin","formation",";","reduces","the","size","of","a","chromosomal","region","converted","to","heterochromatin","."),4341708). assertion_content_comment('tOboGo_NegativeRegulationOfExtracellularMatrixConstituentSecretion',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","the","controlled","release","of","molecules","that","form","the","extracellular","matrix",",","including","carbohydrates","and","glycoproteins","by","a","cell","or","a","group","of","cells","."),4006408). assertion_content_comment('tOboGo_NegativeRegulationOfExtracellularMatrixDisassembly',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","extracellular","matrix","disassembly",".","Extracellular","matrix","disassembly","is","a","process","that","results","in","the","breakdown","of","the","extracellular","matrix","."),4027013). assertion_content_comment('tOboGo_NegativeRegulationOfExtraocularSkeletalMuscleDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","extraocular","skeletal","muscle","development",".","Extraocular","skeletal","muscle","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","extraocular","skeletal","muscle","over","time",",","from","its","formation","to","the","mature","structure",".","The","extraocular","muscle","is","derived","from","cranial","mesoderm","and","controls","eye","movements",".","The","muscle","begins","its","development","with","the","differentiation","of","the","muscle","cells","and","ends","with","the","mature","muscle","."),4040315). assertion_content_comment('tOboGo_NegativeRegulationOfExtrathymicTCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","extrathymic","T","cell","differentiation","."),4066205). assertion_content_comment('tOboGo_NegativeRegulationOfEyePhotoreceptorCellDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","eye","photoreceptor","development","."),4078766). assertion_content_comment('tOboGo_NegativeRegulationOfEyePigmentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","eye","of","an","organism","."),4104173). assertion_content_comment('tOboGo_NegativeRegulationOfFasLBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","FasL","."),4086181). assertion_content_comment('tOboGo_NegativeRegulationOfFatCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","adipocyte","differentiation","."),4088334). assertion_content_comment('tOboGo_NegativeRegulationOfFatCellProliferation',s("Any","process","that","stops","or","decreases","the","rate","or","extent","of","fat","cell","proliferation","."),4136649). assertion_content_comment('tOboGo_NegativeRegulationOfFattyAcidBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","fatty","acids","."),4058507). assertion_content_comment('tOboGo_NegativeRegulationOfFattyAcidMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","fatty","acids","."),4058055). assertion_content_comment('tOboGo_NegativeRegulationOfFattyAcidOxidation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","fatty","acid","oxidation","."),4058064). assertion_content_comment('tOboGo_NegativeRegulationOfFattyAcidTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","fatty","acid","transport","."),4024854). assertion_content_comment('tOboGo_NegativeRegulationOfFeedingBehavior',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","feeding","behavior","."),4140384). assertion_content_comment('tOboGo_NegativeRegulationOfFemaleGonadDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","female","gonad","development","."),4141415). assertion_content_comment('tOboGo_NegativeRegulationOfFemalePigmentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","females","."),4104387). assertion_content_comment('tOboGo_NegativeRegulationOfFemaleReceptivity',s("Any","process","that","stops",",","prevents","or","reduces","the","receptiveness","of","a","female","to","male","advances","."),4235017). assertion_content_comment('tOboGo_NegativeRegulationOfFertilization',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","fertilization",".","Fertilization","is","the","union","of","gametes","of","opposite","sexes","during","the","process","of","sexual","reproduction","to","form","a","zygote",".","It","involves","the","fusion","of","the","gametic","nuclei","(","karyogamy",")","and","cytoplasm","(","plasmogamy",")"),4117819). assertion_content_comment('tOboGo_NegativeRegulationOfFeverGeneration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","or","extent","of","fever","generation","."),4059973). assertion_content_comment('tOboGo_NegativeRegulationOfFibrinolysis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","fibrinolysis",",","an","ongoing","process","that","solubilizes","fibrin",",","resulting","in","the","removal","of","small","blood","clots","."),4120250). assertion_content_comment('tOboGo_NegativeRegulationOfFibroblastApoptosis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","fibroblast","apoptosis","."),4140236). assertion_content_comment('tOboGo_NegativeRegulationOfFibroblastGrowthFactorProduction',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","appearance","of","a","fibroblast","growth","factor","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4151807). assertion_content_comment('tOboGo_NegativeRegulationOfFibroblastGrowthFactorReceptorSignalingPathwayInvolvedInNeuralPlateAnteriorPosteriorPatternFormation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","fibroblast","growth","factor","receptor","signaling","pathway","involved","in","neural","plate","anterior/posterior","pattern","formation","."),4139795). assertion_content_comment('tOboGo_NegativeRegulationOfFibroblastGrowthFactorReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","fibroblast","growth","factor","receptor","signaling","pathway","activity","."),4081805). assertion_content_comment('tOboGo_NegativeRegulationOfFibroblastMigration',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","fibroblast","cell","migration",".","Fibroblast","cell","migration","is","accomplished","by","extension","and","retraction","of","a","pseudopodium","."),4025059). assertion_content_comment('tOboGo_NegativeRegulationOfFibroblastProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","multiplication","or","reproduction","of","fibroblast","cells","."),4103524). assertion_content_comment('tOboGo_NegativeRegulationOfFilamentousGrowth',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","process","in","which","a","multicellular","organism","or","a","group","of","unicellular","organisms","grow","in","a","threadlike",",","filamentous","shape","."),4116150). assertion_content_comment('tOboGo_NegativeRegulationOfFilopodiumAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","assembly","of","a","filopodium",",","a","thin",",","stiff","protrusion","extended","by","the","leading","edge","of","a","motile","cell","such","as","a","crawling","fibroblast","or","amoeba",",","or","an","axonal","growth","cone","."),4118986). assertion_content_comment('tOboGo_NegativeRegulationOfFlagellarCellMotility',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","flagellar","cell","motility","."),4137810). assertion_content_comment('tOboGo_NegativeRegulationOfFlagellumAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","formation","of","a","flagellum","."),4091221). assertion_content_comment('tOboGo_NegativeRegulationOfFlavonoidBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","flavonoids","."),4033170). assertion_content_comment('tOboGo_NegativeRegulationOfFlocculation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","non-sexual","aggregation","of","single-celled","organisms","."),4116171). assertion_content_comment('tOboGo_NegativeRegulationOfFloralOrganAbscissionByTransmembraneReceptorProteinSerineThreonineKinaseSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","transmembrane","receptor","serine/threonine","kinase","binding","to","its","physiological","ligand","and","contributing","to","the","decrease","in","the","rate","or","frequency","of","floral","organ","abscission","."),4156481). assertion_content_comment('tOboGo_NegativeRegulationOfFloralOrganAbscission',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","floral","organ","abscission",",","the","controlled","shedding","of","floral","organs","."),4113931). assertion_content_comment('tOboGo_NegativeRegulationOfFlowerDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","flower","development","."),4021366). assertion_content_comment('tOboGo_NegativeRegulationOfFocalAdhesionAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","focal","adhesion","assembly",",","the","establishment","and","maturation","of","focal","adhesions","."),4122382). assertion_content_comment('tOboGo_NegativeRegulationOfFormationBySymbiontOfHaustoriumForNutrientAcquisitionFromHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","haustorium","formation","for","nutrient","acquisition","from","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147100). assertion_content_comment('tOboGo_NegativeRegulationOfFractalkineBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","fractalkine",",","a","chemokine","involved","in","the","control","of","the","key","regulatory","mechanisms","of","cell","trafficking","at","sites","of","inflammation","."),4101209). assertion_content_comment('tOboGo_NegativeRegulationOfFractalkineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","fractalkine","production","."),4068539). assertion_content_comment('tOboGo_NegativeRegulationOfFusionCellFateSpecification',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","adopting","a","fusion","cell","fate",".","Once","the","terminal","and","fusion","fates","have","been","correctly","induced",",","inhibitory","feedback","loops","prevent","the","remaining","branch","cells","from","assuming","similar","fates","."),4071790). assertion_content_comment('tOboGo_NegativeRegulationOfFusionOfSpermToEggPlasmaMembrane',s("Any","process","that","stops","or","prevents","the","binding","and","fusion","of","a","sperm","to","the","oocyte","plasma","membrane","."),4093934). assertion_content_comment('tOboGo_NegativeRegulationOfG0ToG1Transition',s("A","cell","cycle","process","that","stops",",","prevents",",","or","reduces","the","rate","or","extent","of","the","transition","from","the","G0","quiescent","state","to","the","G1","phase","."),4137314). assertion_content_comment('tOboGo_NegativeRegulationOfG1STransitionOfMitoticCellCycle',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","G1/S","transition","of","mitotic","cell","cycle","."),4138085). assertion_content_comment('tOboGo_NegativeRegulationOfG2MTransitionOfMitoticCellCycle',s("Any","process","that","decreases","the","rate","or","extent","of","progression","from","G2","phase","to","M","phase","of","the","mitotic","cell","cycle","."),4035450). assertion_content_comment('tOboGo_NegativeRegulationOfGastricAcidSecretion',s("Any","process","that","decreases","the","rate","frequency","or","extent","of","gastric","secretion",".","Gastric","secretion","is","the","regulated","release","of","gastric","acid","(","hydrochloric","acid",")","by","parietal","or","oxyntic","cells","during","digestion","."),4117797). assertion_content_comment('tOboGo_NegativeRegulationOfGastrulation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","gastrulation","."),4145195). assertion_content_comment('tOboGo_NegativeRegulationOfGeneExpressionEpigenetic',s("Any","epigenetic","process","that","stops",",","prevents","or","reduces","the","rate","of","gene","expression","."),4009285). assertion_content_comment('tOboGo_NegativeRegulationOfGeneExpression',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","gene","expression",".","Gene","expression","is","the","process","in","which","a","gene","'","s","coding","sequence","is","converted","into","a","mature","gene","product","or","products","(","proteins","or","RNA",")","This","includes","the","production","of","an","RNA","transcript","as","well","as","any","processing","to","produce","a","mature","RNA","product","or","an","mRNA","(","for","protein-coding","genes",")","and","the","translation","of","that","mRNA","into","protein",".","Some","protein","processing","events","may","be","included","when","they","are","required","to","form","an","active","form","of","a","product","from","an","inactive","precursor","form","."),3971496). assertion_content_comment('tOboGo_NegativeRegulationOfGeneSilencingByMiRNA',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","downregulation","of","gene","expression","through","the","action","of","microRNAs","(","miRNAs",")",",","endogenous","21-24","nucleotide","small","RNAs","processed","from","stem-loop","RNA","precursors","(","pre-miRNAs",")","Once","incorporated","into","a","RNA-induced","silencing","complex","(","RISC",")",",","miRNAs","can","downregulate","gene","expression","by","either","of","two","posttranscriptional","mechanisms",":","mRNA","cleavage","or","translational","repression","."),4112991). assertion_content_comment('tOboGo_NegativeRegulationOfGeneSilencingByRNA',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","gene","silencing","by","RNA",".","Gene","silencing","by","RNA","is","the","process","in","which","RNA","molecules","inactivate","expression","of","target","genes","."),4112968). assertion_content_comment('tOboGo_NegativeRegulationOfGeneSilencing',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","gene","silencing",",","the","transcriptional","or","post-transcriptional","process","carried","out","at","the","cellular","level","that","results","in","long-term","gene","inactivation","."),4057691). assertion_content_comment('tOboGo_NegativeRegulationOfGerminalCenterFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","germinal","center","formation","."),3995666). assertion_content_comment('tOboGo_NegativeRegulationOfGermTubeFormationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","germ","tube","formation","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147354). assertion_content_comment('tOboGo_NegativeRegulationOfGibberellicAcidMediatedSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","gibberellic","acid","mediated","signaling","activity","."),4033362). assertion_content_comment('tOboGo_NegativeRegulationOfGibberellinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","gibberellins","."),4031351). assertion_content_comment('tOboGo_NegativeRegulationOfGlialCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","glial","cell","apoptosis","."),4075190). assertion_content_comment('tOboGo_NegativeRegulationOfGlialCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","glia","cell","differentiation","."),4036404). assertion_content_comment('tOboGo_NegativeRegulationOfGlialCellProliferation',s("Any","process","that","stops","or","decreases","the","rate","or","extent","of","glial","cell","proliferation","."),4028647). assertion_content_comment('tOboGo_NegativeRegulationOfGliogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","gliogenesis",",","the","formation","of","mature","glia","."),4028639). assertion_content_comment('tOboGo_NegativeRegulationOfGlomerularFiltrationByAngiotensin',s("The","process","in","which","angiotensin","directly","decreases","the","rate","of","glomerular","filtration","in","the","kidney",".","Glomerular","filtration","is","the","processs","whereby","blood","is","filtered","by","the","glomerulus","into","the","renal","tubule","."),4004045). assertion_content_comment('tOboGo_NegativeRegulationOfGlomerularMesangialCellProliferation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","glomerular","mesangial","cell","proliferation","."),4122756). assertion_content_comment('tOboGo_NegativeRegulationOfGlomerulusDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","glomerulus","development",",","the","progression","of","the","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney","."),4124591). assertion_content_comment('tOboGo_NegativeRegulationOfGlucagonSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","glucagon","."),4133030). assertion_content_comment('tOboGo_NegativeRegulationOfGlucocorticoidBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucocorticoids","."),4057563). assertion_content_comment('tOboGo_NegativeRegulationOfGlucocorticoidCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucocorticoids","."),4057505). assertion_content_comment('tOboGo_NegativeRegulationOfGlucocorticoidMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","glucocorticoids","."),4057495). assertion_content_comment('tOboGo_NegativeRegulationOfGlucocorticoidReceptorSignalingPathway',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","glucocorticoid","receptor","signaling","pathway","."),4139686). assertion_content_comment('tOboGo_NegativeRegulationOfGlucokinaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","glucokinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","glucose","molecule","."),4347971). assertion_content_comment('tOboGo_NegativeRegulationOfGluconateTransmembraneTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","gluconate","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083107). assertion_content_comment('tOboGo_NegativeRegulationOfGluconateTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","gluconate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4064720). assertion_content_comment('tOboGo_NegativeRegulationOfGluconeogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","gluconeogenesis","."),4091261). assertion_content_comment('tOboGo_NegativeRegulationOfGlucoseImport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","import","of","the","hexose","monosaccharide","glucose","into","a","cell","or","organelle","."),4098160). assertion_content_comment('tOboGo_NegativeRegulationOfGlucoseTransport',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","glucose","transport",".","Glucose","transport","is","the","directed","movement","of","the","hexose","monosaccharide","glucose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4036571). assertion_content_comment('tOboGo_NegativeRegulationOfGlucosylceramideBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosylceramide","."),4098460). assertion_content_comment('tOboGo_NegativeRegulationOfGlutamateMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","glutamate","metabolic","process","."),4141214). assertion_content_comment('tOboGo_NegativeRegulationOfGlutamateSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","controlled","release","of","glutamate","."),4039673). assertion_content_comment('tOboGo_NegativeRegulationOfGlutamateUptakeInvolvedInTransmissionOfNerveImpulse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","L-glutamate","into","a","neuron","or","glial","cell","."),4120593). assertion_content_comment('tOboGo_NegativeRegulationOfGlutamineTransport',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","glutamine","transport","."),4145824). assertion_content_comment('tOboGo_NegativeRegulationOfGlycerolTransport',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","directed","movement","of","glycerol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4151283). assertion_content_comment('tOboGo_NegativeRegulationOfGlycogenBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycogen","."),4091240). assertion_content_comment('tOboGo_NegativeRegulationOfGlycogenCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycogen","."),4090576). assertion_content_comment('tOboGo_NegativeRegulationOfGlycogenMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","glycogen","."),4090572). assertion_content_comment('tOboGo_NegativeRegulationOfGlycogenStarchSynthaseActivity',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","glycogen","(","starch",")","synthase","activity","."),4171989). assertion_content_comment('tOboGo_NegativeRegulationOfGlycolysis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","glycolysis","."),4090598). assertion_content_comment('tOboGo_NegativeRegulationOfGlycoproteinBiosyntheticProcess',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycoproteins",",","any","protein","that","contains","covalently","bound","glycose","(","i.e",".","monosaccharide",")","residues",";","the","glycose","occurs","most","commonly","as","oligosaccharide","or","fairly","small","polysaccharide","but","occasionally","as","monosaccharide","."),4027943). assertion_content_comment('tOboGo_NegativeRegulationOfGolgiToPlasmaMembraneCFTRProteinTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transport","of","Cystic","Fibrosis","Transmembrane","conductance","Regulator","(","CFTR",")","protein","from","the","Golgi","to","the","plasma","membrane","."),4093871). assertion_content_comment('tOboGo_NegativeRegulationOfGolgiToPlasmaMembraneProteinTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","transport","of","proteins","from","the","Golgi","to","the","plasma","membrane","."),4093853). assertion_content_comment('tOboGo_NegativeRegulationOfGolgiVesicleFusionToTargetMembrane',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Golgi","vesicle","fusion","to","target","membrane","."),4103305). assertion_content_comment('tOboGo_NegativeRegulationOfGonadotropinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","gonadotropin","."),4054823). assertion_content_comment('tOboGo_NegativeRegulationOfGranulocyteChemotaxis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","granulocyte","chemotaxis",".","Granulocyte","chemotaxis","is","the","movement","of","a","granulocyte","in","response","to","an","external","stimulus","."),4130243). assertion_content_comment('tOboGo_NegativeRegulationOfGranulocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","granulocyte","differentiation","."),4061745). assertion_content_comment('tOboGo_NegativeRegulationOfGranulomaFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","granuloma","formation","."),3995821). assertion_content_comment('tOboGo_NegativeRegulationOfGranzymeAProduction',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","granzyme","A","production","."),4144888). assertion_content_comment('tOboGo_NegativeRegulationOfGranzymeBProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","production","of","granzyme","B","."),4129229). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthHormoneReceptorSignalingPathway',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","growth","hormone","receptor","signaling","pathway",".","The","growth","hormone","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","growth","hormone","receptor","binding","to","its","physiological","ligand","."),4117419). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthHormoneSecretion',s("Any","process","that","decreases","or","stops","the","frequency",",","rate","or","extent","of","the","regulated","release","of","growth","hormone","from","a","cell","or","group","of","cells","."),4109013). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthOfSymbiontInHost',s("Any","process","in","which","the","symbiont","stops",",","prevents","or","reduces","its","increase","in","size","or","mass","within","the","cells","or","tissues","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4097830). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthOfSymbiontInvolvedInInteractionWithHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","increase","in","size","or","mass","of","an","organism","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4097584). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthOfSymbiontOnOrNearHostSurface',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","increase","in","the","symbiont","'","s","size","or","mass","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4097588). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthOfUnicellularOrganismAsAThreadOfAttachedCells',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","process","in","which","cells","remain","attached","after","division","and","form","thread-like","filaments","that","may","penetrate","into","a","solid","growth","medium","."),4132688). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthOrDevelopmentOfSymbiontDuringInteractionWithHost',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","increase","in","size","or","mass","of","an","organism",",","or","the","progression","of","an","organism","from","an","initial","condition","to","a","later","condition",",","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4154660). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthOrDevelopmentOfSymbiontInHost',s("OBSOLETE",".","Any","process","by","which","the","symbiont","stops",",","prevents","or","reduces","its","increase","in","size","or","mass","or","its","progression","from","an","initial","condition","to","a","later","condition",",","within","the","cells","or","tissues","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4341245). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthOrDevelopmentOfSymbiontOnOrNearHostSurface',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","increase","in","the","symbiont","'","s","size","or","mass",",","or","its","progression","from","an","initial","condition","to","a","later","condition",",","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4154696). assertion_content_comment('tOboGo_NegativeRegulationOfGrowthRate',s("Any","process","that","reduces","the","rate","of","growth","of","all","or","part","of","an","organism","."),4297993). assertion_content_comment('tOboGo_NegativeRegulationOfGrowth',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","growth",",","the","increase","in","size","or","mass","of","all","or","part","of","an","organism","."),4046567). assertion_content_comment('tOboGo_NegativeRegulationOfGTPaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","GTP","hydrolysis","by","a","GTPase","."),4304631). assertion_content_comment('tOboGo_NegativeRegulationOfGTPCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","GTP",",","guanosine","triphosphate","."),4065948). assertion_content_comment('tOboGo_NegativeRegulationOfGTPCyclohydrolaseIActivity',s("Any","process","that","stops","or","reduces","the","activity","of","the","enzyme","GTP","cyclohydrolase","I","."),4317752). assertion_content_comment('tOboGo_NegativeRegulationOfGuanylateCyclaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","guanylate","cyclase","activity","."),4320181). assertion_content_comment('tOboGo_NegativeRegulationOfHairCycle',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","cyclical","phases","of","growth","(","anagen",")",",","regression","(","catagen",")",",","quiescence","(","telogen",")",",","and","shedding","(","exogen",")","in","the","life","of","a","hair","."),4077852). assertion_content_comment('tOboGo_NegativeRegulationOfHairFollicleCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","hair","follicle","cell","proliferation","."),4128343). assertion_content_comment('tOboGo_NegativeRegulationOfHairFollicleDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","hair","follicle","development","."),4105197). assertion_content_comment('tOboGo_NegativeRegulationOfHairFollicleMaturation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","hair","follicle","maturation","."),4105204). assertion_content_comment('tOboGo_NegativeRegulationOfHairFolliclePlacodeFormation',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","hair","follicle","placode","formation",",","the","developmental","process","in","which","a","hair","placode","forms",".","An","hair","follicle","placode","is","a","thickening","of","the","ectoderm","that","will","give","rise","to","the","hair","follicle","bud","."),4135918). assertion_content_comment('tOboGo_NegativeRegulationOfHaustoriumMotherCellFormationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","haustorium","mother","cell","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146681). assertion_content_comment('tOboGo_NegativeRegulationOfHeartContraction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","heart","contraction","."),3987514). assertion_content_comment('tOboGo_NegativeRegulationOfHeartGrowth',s("Any","process","that","decreases","the","rate","or","extent","of","heart","growth",".","Heart","growth","is","the","increase","in","size","or","mass","of","the","heart","."),4107790). assertion_content_comment('tOboGo_NegativeRegulationOfHeartInductionByCanonicalWntReceptorSignalingPathway',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","heart","induction","."),4003514). assertion_content_comment('tOboGo_NegativeRegulationOfHeartRateByAcetylcholine',s("The","process","in","which","acetylcholine","released","from","vagus","nerve","endings","binds","to","muscarinic","receptors","on","the","pacemaker","cells","and","decreases","the","rate","of","heart","muscle","contraction","."),4003822). assertion_content_comment('tOboGo_NegativeRegulationOfHeartRateInvolvedInBaroreceptorResponseToIncreasedSystemicArterialBloodPressure',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","heart","contraction","as","a","result","of","the","baroreceptor","response","to","increased","blood","pressure","."),3987524). assertion_content_comment('tOboGo_NegativeRegulationOfHeartRate',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency","or","rate","of","heart","contraction","."),3987521). assertion_content_comment('tOboGo_NegativeRegulationOfHeatDissipation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","or","extent","of","heat","dissipation","."),4059782). assertion_content_comment('tOboGo_NegativeRegulationOfHeatGeneration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","or","extent","of","heat","generation","."),4059835). assertion_content_comment('tOboGo_NegativeRegulationOfHelicaseActivity',s("Any","process","that","stops","or","reduces","the","activity","of","a","helicase","."),4287184). assertion_content_comment('tOboGo_NegativeRegulationOfHematopoieticStemCellMigration',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","hematopoietic","stem","cell","migration","."),4145456). assertion_content_comment('tOboGo_NegativeRegulationOfHemeBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","heme","."),4131373). assertion_content_comment('tOboGo_NegativeRegulationOfHemocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","hemocyte","differentiation","."),4072242). assertion_content_comment('tOboGo_NegativeRegulationOfHemocyteProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","hemocyte","proliferation",".","Hemocytes","are","blood","cells","associated","with","a","hemocoel","(","the","cavity","containing","most","of","the","major","organs","of","the","arthropod","body",")","which","are","involved","in","defense","and","clotting","of","hemolymph",",","but","not","involved","in","transport","of","oxygen",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4072149). assertion_content_comment('tOboGo_NegativeRegulationOfHemoglobinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hemoglobin",",","an","oxygen","carrying",",","conjugated","protein","containing","four","heme","groups","and","globin","."),4099861). assertion_content_comment('tOboGo_NegativeRegulationOfHepaticStellateCellActivation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","hepatic","stellate","cell","activation","."),4145903). assertion_content_comment('tOboGo_NegativeRegulationOfHepatocyteDifferentiation',s("Any","process","that","stops","or","decreases","the","rate","or","extent","of","hepatocyte","differentiation","."),4136926). assertion_content_comment('tOboGo_NegativeRegulationOfHepatocyteGrowthFactorBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hepatocyte","growth","factor","."),4103446). assertion_content_comment('tOboGo_NegativeRegulationOfHepatocyteGrowthFactorProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","hepatocyte","growth","factor","production","."),4068862). assertion_content_comment('tOboGo_NegativeRegulationOfHepatocyteProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","hepatocyte","proliferation","."),4143413). assertion_content_comment('tOboGo_NegativeRegulationOfHeterochromatinFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","heterochromatin","formation","."),4058362). assertion_content_comment('tOboGo_NegativeRegulationOfHindgutContraction',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","muscle","contraction","of","the","hindgut",",","the","posterior","part","of","the","alimentary","canal",",","including","the","rectum",",","and","the","large","intestine","."),4117659). assertion_content_comment('tOboGo_NegativeRegulationOfHippoSignalingCascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","hippo","signaling","."),4071367). assertion_content_comment('tOboGo_NegativeRegulationOfHistamineUptake',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","histamine","into","a","cell","."),4121728). assertion_content_comment('tOboGo_NegativeRegulationOfHistolysis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","breakdown","of","tissues",";","usually",",","if","not","always",",","accompanied","by","cell","death","."),4026808). assertion_content_comment('tOboGo_NegativeRegulationOfHistoneAcetylation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","addition","of","an","acetyl","group","to","a","histone","protein","."),4072883). assertion_content_comment('tOboGo_NegativeRegulationOfHistoneDeacetylationAtCentromere',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","removal","of","acetyl","groups","to","histones","in","centromeric","DNA","."),4062854). assertion_content_comment('tOboGo_NegativeRegulationOfHistoneDeacetylation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","removal","of","acetyl","groups","from","histones","."),4062846). assertion_content_comment('tOboGo_NegativeRegulationOfHistoneH4Acetylation',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","histone","H4","acetylation",",","the","modification","of","histone","H4","by","the","addition","of","an","acetyl","group","."),4143556). assertion_content_comment('tOboGo_NegativeRegulationOfHistoneMethylation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","covalent","addition","of","methyl","groups","to","histones","."),3975748). assertion_content_comment('tOboGo_NegativeRegulationOfHistoneModification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","covalent","alteration","of","a","histone","."),3975740). assertion_content_comment('tOboGo_NegativeRegulationOfHistonePhosphorylation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","addition","of","one","or","more","phosphate","groups","to","a","histone","protein","."),4065984). assertion_content_comment('tOboGo_NegativeRegulationOfHistoneUbiquitination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","addition","of","a","ubiquitin","group","to","a","histone","protein","."),4065499). assertion_content_comment('tOboGo_NegativeRegulationOfHomeostaticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","homeostatic","process","."),4029762). assertion_content_comment('tOboGo_NegativeRegulationOfHomocysteineMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","homocysteine","."),4101438). assertion_content_comment('tOboGo_NegativeRegulationOfHormoneBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hormones","."),4029380). assertion_content_comment('tOboGo_NegativeRegulationOfHormoneMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","any","hormone","."),4029371). assertion_content_comment('tOboGo_NegativeRegulationOfHormoneSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","hormone","from","a","cell","or","group","of","cells","."),4054816). assertion_content_comment('tOboGo_NegativeRegulationOfHulleCellDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Hulle","cell","development",",","a","process","that","leads","to","the","formation","of","Hulle","cells",".","Hulle","cells","are","specialized","multinucleate","cells","that","originate","from","a","nest-like","aggregation","of","hyphae","during","sexual","development","and","serve","as","nurse","cells","to","the","developing","cleistothecium",",","or","fruiting","body","."),4132479). assertion_content_comment('tOboGo_NegativeRegulationOfHumoralImmuneResponseMediatedByCirculatingImmunoglobulin',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","humoral","immune","response","mediated","by","circulating","immunoglobulin","."),3999784). assertion_content_comment('tOboGo_NegativeRegulationOfHumoralImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","humoral","immune","response","."),3986316). assertion_content_comment('tOboGo_NegativeRegulationOfHydrogenPeroxideBiosyntheticProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","hydrogen","peroxide","biosynthesis",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hydrogen","peroxide","(","H2O2",")",",","a","potentially","harmful","byproduct","of","aerobic","cellular","respiration","which","can","cause","damage","to","DNA","."),4024449). assertion_content_comment('tOboGo_NegativeRegulationOfHydrogenPeroxideCatabolicProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","hydrogen","peroxide","catabolic","process","."),4139967). assertion_content_comment('tOboGo_NegativeRegulationOfHydrogenPeroxideMetabolicProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","hydrogen","peroxide","."),4024317). assertion_content_comment('tOboGo_NegativeRegulationOfHydrolaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","hydrolase","activity",",","the","catalysis","of","the","hydrolysis","of","various","bonds","."),4061636). assertion_content_comment('tOboGo_NegativeRegulationOfHypersensitivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","hypersensitivity","."),3983864). assertion_content_comment('tOboGo_NegativeRegulationOfHyphopodiumFormationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","hyphopodium","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146647). assertion_content_comment('tOboGo_NegativeRegulationOfHypoxanthineTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","hypoxanthine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083506). assertion_content_comment('tOboGo_NegativeRegulationOfIcosanoidSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","controlled","release","of","an","icosanoid","from","a","cell","or","group","of","cells","."),4054724). assertion_content_comment('tOboGo_NegativeRegulationOfImaginalDiscGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","imaginal","disc","growth","."),4087965). assertion_content_comment('tOboGo_NegativeRegulationOfImmatureTCellProliferationInThymus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","immature","T","cell","proliferation","in","the","thymus","."),4066247). assertion_content_comment('tOboGo_NegativeRegulationOfImmatureTCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","immature","T","cell","proliferation","."),4066236). assertion_content_comment('tOboGo_NegativeRegulationOfImmuneEffectorProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","immune","effector","process","."),3983894). assertion_content_comment('tOboGo_NegativeRegulationOfImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","immune","response",",","the","immunological","reaction","of","an","organism","to","an","immunogenic","stimulus","."),3983841). assertion_content_comment('tOboGo_NegativeRegulationOfImmuneResponseToTumorCell',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","immune","response","to","tumor","cell","."),4000044). assertion_content_comment('tOboGo_NegativeRegulationOfImmuneSystemProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","immune","system","process","."),3983832). assertion_content_comment('tOboGo_NegativeRegulationOfImmunoglobulinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","immunoglobulin","biosynthesis","."),3995545). assertion_content_comment('tOboGo_NegativeRegulationOfImmunoglobulinMediatedImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","immunoglobulin","mediated","immune","response","."),3983988). assertion_content_comment('tOboGo_NegativeRegulationOfImmunoglobulinProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","immunoglobulin","production","."),3995503). assertion_content_comment('tOboGo_NegativeRegulationOfImmunoglobulinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","immunoglobulins","from","a","cell","or","group","of","cells","."),4119192). assertion_content_comment('tOboGo_NegativeRegulationOfImmunologicalSynapseFormation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","immunological","synapse","formation","."),4144924). assertion_content_comment('tOboGo_NegativeRegulationOfInclusionBodyAssembly',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","inclusion","body","assembly",".","Inclusion","body","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","inclusion","body","."),4150320). assertion_content_comment('tOboGo_NegativeRegulationOfInductionOfApoptosisInResponseToChemicalStimulus',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","induction","of","apoptosis","in","response","to","chemical","stimulus","."),4145650). assertion_content_comment('tOboGo_NegativeRegulationOfInductionOfConjugationWithCellularFusion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency","or","rate","of","initiation","of","conjugation","with","cellular","fusion","."),4029965). assertion_content_comment('tOboGo_NegativeRegulationOfInfectionCushionFormationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","infection","cushion","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146601). assertion_content_comment('tOboGo_NegativeRegulationOfInflammatoryResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","inflammatory","response","."),3983793). assertion_content_comment('tOboGo_NegativeRegulationOfInflammatoryResponseToAntigenicStimulus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","an","inflammatory","response","to","an","antigenic","stimulus","."),3983848). assertion_content_comment('tOboGo_NegativeRegulationOfInhibinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","inhibin","from","a","cell","or","group","of","cells","."),4056197). assertion_content_comment('tOboGo_NegativeRegulationOfInitiationOfAcetateCatabolicProcessByAcetate',s("Any","process","that","stops","or","prevents","the","activation",",","by","acetate",",","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate","."),4091131). assertion_content_comment('tOboGo_NegativeRegulationOfInnateImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","innate","immune","response","."),3986292). assertion_content_comment('tOboGo_NegativeRegulationOfInosineTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","inosine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083454). assertion_content_comment('tOboGo_NegativeRegulationOfInositolPhosphateBiosyntheticProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","inositol","phosphate","biosynthesis",".","Inositol","phosphate","biosynthetic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","inositol","phosphate",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","with","one","or","more","phosphate","groups","attached","."),4034846). assertion_content_comment('tOboGo_NegativeRegulationOfInositolTrisphosphateBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","inositol","trisphosphate","."),4063820). assertion_content_comment('tOboGo_NegativeRegulationOfInsulinReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","insulin","receptor","signaling","."),4098867). assertion_content_comment('tOboGo_NegativeRegulationOfInsulinSecretionInvolvedInCellularResponseToGlucoseStimulus',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","insulin","that","contributes","to","the","response","of","a","cell","to","glucose","."),4135874). assertion_content_comment('tOboGo_NegativeRegulationOfInsulinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","insulin","."),4099206). assertion_content_comment('tOboGo_NegativeRegulationOfIntegrinActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","integrin","activation","."),4063635). assertion_content_comment('tOboGo_NegativeRegulationOfIntegrinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","integrins","."),4090828). assertion_content_comment('tOboGo_NegativeRegulationOfIntermediateFilamentDepolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","intermediate","filament","depolymerization","."),4051483). assertion_content_comment('tOboGo_NegativeRegulationOfIntermediateFilamentPolymerizationAndOrDepolymerization',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","intermediate","filament","polymerization","and/or","depolymerization","."),4298216). assertion_content_comment('tOboGo_NegativeRegulationOfIntermediateFilamentPolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","intermediate","filament","polymerization","."),4051540). assertion_content_comment('tOboGo_NegativeRegulationOfIntermediateMesodermalCellFateDetermination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","intermediate","mesoderm","cell","fate","determination","."),4102143). assertion_content_comment('tOboGo_NegativeRegulationOfIntermediateMesodermalCellFateSpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","intermediate","mesoderm","cell","fate","specification","."),4102025). assertion_content_comment('tOboGo_NegativeRegulationOfIntestinalCholesterolAbsorption',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","uptake","of","cholesterol","into","the","blood","by","absorption","from","the","intestine","."),4090986). assertion_content_comment('tOboGo_NegativeRegulationOfIntestinalPhytosterolAbsorption',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","phytosterols","into","the","blood","by","absorption","from","the","small","intestine","."),4035352). assertion_content_comment('tOboGo_NegativeRegulationOfIntracellularCholesterolTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","cholesterol","within","cells","."),4056637). assertion_content_comment('tOboGo_NegativeRegulationOfIntracellularLipidTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","lipids","within","cells","."),4056621). assertion_content_comment('tOboGo_NegativeRegulationOfIntracellularProteinKinaseCascade',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","a","series","of","reactions",",","mediated","by","protein","kinases",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4024686). assertion_content_comment('tOboGo_NegativeRegulationOfIntracellularProteinTransport',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","proteins","within","cells","."),4016393). assertion_content_comment('tOboGo_NegativeRegulationOfIntracellularSterolTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","sterols","within","cells","."),4056629). assertion_content_comment('tOboGo_NegativeRegulationOfIntracellularTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","within","cells","."),4016368). assertion_content_comment('tOboGo_NegativeRegulationOfInvasiveGrowthInResponseToGlucoseLimitation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","invasive","growth","in","response","to","glucose","limitation","."),4140784). assertion_content_comment('tOboGo_NegativeRegulationOfIonTransmembraneTransporterActivity',s("Any","process","that","stops","or","reduces","the","activity","of","an","ion","transporter","."),4160474). assertion_content_comment('tOboGo_NegativeRegulationOfIonTransmembraneTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","ions","from","one","side","of","a","membrane","to","the","other","."),4073262). assertion_content_comment('tOboGo_NegativeRegulationOfIonTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","charged","atoms","or","small","charged","molecules","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990692). assertion_content_comment('tOboGo_NegativeRegulationOfIridophoreDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","iridophore","differentiation","."),4100129). assertion_content_comment('tOboGo_NegativeRegulationOfIronIonTransmembraneTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","iron","ions","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4073387). assertion_content_comment('tOboGo_NegativeRegulationOfIronIonTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","iron","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4073351). assertion_content_comment('tOboGo_NegativeRegulationOfIsoprenoidMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","isoprenoid","."),4031342). assertion_content_comment('tOboGo_NegativeRegulationOfIsotypeSwitching',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","isotype","switching","."),4090669). assertion_content_comment('tOboGo_NegativeRegulationOfIsotypeSwitchingToIgAIsotypes',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgA","isotypes","."),4103866). assertion_content_comment('tOboGo_NegativeRegulationOfIsotypeSwitchingToIgDIsotypes',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgD","isotypes","."),4103607). assertion_content_comment('tOboGo_NegativeRegulationOfIsotypeSwitchingToIgEIsotypes',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgE","isotypes","."),4103805). assertion_content_comment('tOboGo_NegativeRegulationOfIsotypeSwitchingToIgGIsotypes',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgG","isotypes","."),4103668). assertion_content_comment('tOboGo_NegativeRegulationOfJNKCascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","JNK","cascade","."),4098088). assertion_content_comment('tOboGo_NegativeRegulationOfJUNKinaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","JUN","kinase","activity","."),4324625). assertion_content_comment('tOboGo_NegativeRegulationOfJuvenileHormoneBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","juvenile","hormone","."),4092538). assertion_content_comment('tOboGo_NegativeRegulationOfJuvenileHormoneCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","juvenile","hormone","."),4092496). assertion_content_comment('tOboGo_NegativeRegulationOfJuvenileHormoneMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","juvenile","hormone","."),4089766). assertion_content_comment('tOboGo_NegativeRegulationOfJuvenileHormoneSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","juvenile","hormone","."),4092446). assertion_content_comment('tOboGo_NegativeRegulationOfKeratinocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","keratinocyte","differentiation","."),4087269). assertion_content_comment('tOboGo_NegativeRegulationOfKeratinocyteMigration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","keratinocyte","migration","."),4118889). assertion_content_comment('tOboGo_NegativeRegulationOfKeratinocyteProliferation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","keratinocyte","proliferation",".","Keratinocyte","proliferation","is","the","multiplication","or","reproduction","of","keratinocytes",",","resulting","in","the","expansion","of","a","cell","population","."),4036809). assertion_content_comment('tOboGo_NegativeRegulationOfKidneyDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","kidney","development",".","Kidney","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","kidney","over","time",",","from","its","formation","to","the","mature","structure",".","The","kidney","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4123461). assertion_content_comment('tOboGo_NegativeRegulationOfKidneySmoothMuscleCellDifferentiation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","kidney","smooth","muscle","cell","differentiation","."),4142848). assertion_content_comment('tOboGo_NegativeRegulationOfKillingOfCellsOfOtherOrganism',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","killing","by","an","organism","of","cells","in","another","organism","."),3986021). assertion_content_comment('tOboGo_NegativeRegulationOfKinaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","substrate","molecule","."),3972873). assertion_content_comment('tOboGo_NegativeRegulationOfKininCascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","the","kinin","cascade","."),3992155). assertion_content_comment('tOboGo_NegativeRegulationOfLamellipodiumAssembly',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","formation","of","a","lamellipodium",",","a","thin","sheetlike","extension","of","the","surface","of","a","migrating","cell","."),4028563). assertion_content_comment('tOboGo_NegativeRegulationOfLamellipodiumMorphogenesis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","lamellipodium","morphogenesis","."),4142463). assertion_content_comment('tOboGo_NegativeRegulationOfLamellocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lamellocyte","differentiation",".","Lamellocytes","differentiate","massively","in","the","lymph","glands","after","parasitization","and","are","large","flat","cells","devoted","to","encapsulation","of","invaders","too","large","to","be","phagocytosed","by","plasmatocytes","."),4072250). assertion_content_comment('tOboGo_NegativeRegulationOfLarvalSalivaryGlandBoundarySpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","salivary","gland","determination","in","a","larval","organism","."),4091680). assertion_content_comment('tOboGo_NegativeRegulationOfLateralMesodermalCellFateDetermination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lateral","mesoderm","cell","fate","determination","."),4102432). assertion_content_comment('tOboGo_NegativeRegulationOfLateralMesodermalCellFateSpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lateral","mesoderm","cell","fate","specification","."),4102333). assertion_content_comment('tOboGo_NegativeRegulationOfLateralPseudopodiumAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","assembly","of","pseudopodia","from","the","lateral","side","of","the","cell","."),4059515). assertion_content_comment('tOboGo_NegativeRegulationOfLateStripeMelanocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","late","stripe","melanocyte","differentiation","."),4100031). assertion_content_comment('tOboGo_NegativeRegulationOfLeucineImportInResponseToAmmoniumIon',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","leucine","import","as","a","result","of","an","ammonium","ion","stimulus",".","Leucine","import","is","the","directed","movement","of","leucine","into","a","cell","or","organelle","."),4160263). assertion_content_comment('tOboGo_NegativeRegulationOfLeucineImport',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","leucine","import",".","Leucine","import","is","the","directed","movement","of","leucine","into","a","cell","or","organelle","."),4115160). assertion_content_comment('tOboGo_NegativeRegulationOfLeucophoreDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","leucophore","differentiation","."),4105019). assertion_content_comment('tOboGo_NegativeRegulationOfLeukocyteActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","leukocyte","activation","."),3989362). assertion_content_comment('tOboGo_NegativeRegulationOfLeukocyteApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","leukocyte","apoptosis","."),3999569). assertion_content_comment('tOboGo_NegativeRegulationOfLeukocyteChemotaxis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","leukocyte","chemotaxis","."),3998164). assertion_content_comment('tOboGo_NegativeRegulationOfLeukocyteDegranulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","leukocyte","degranulation","."),4093477). assertion_content_comment('tOboGo_NegativeRegulationOfLeukocyteMediatedCytotoxicity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","leukocyte","mediated","cytotoxicity","."),3984035). assertion_content_comment('tOboGo_NegativeRegulationOfLeukocyteMediatedImmunity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","leukocyte","mediated","immunity","."),3983902). assertion_content_comment('tOboGo_NegativeRegulationOfLeukocyteMigration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","leukocyte","migration","."),3998060). assertion_content_comment('tOboGo_NegativeRegulationOfLeukocyteProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","leukocyte","proliferation","."),4062077). assertion_content_comment('tOboGo_NegativeRegulationOfLeukotrieneProductionInvolvedInInflammatoryResponse',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","synthesis","or","release","of","any","leukotriene","following","a","stimulus","as","part","of","an","inflammatory","response","."),4084378). assertion_content_comment('tOboGo_NegativeRegulationOfLigaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","ligase","activity",",","the","catalysis","of","the","ligation","of","two","substances","with","concomitant","breaking","of","a","diphosphate","linkage",",","usually","in","a","nucleoside","triphosphate","."),4117031). assertion_content_comment('tOboGo_NegativeRegulationOfLipaseActivity',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","lipase","activity",",","the","hydrolysis","of","a","lipid","or","phospholipid","."),4061644). assertion_content_comment('tOboGo_NegativeRegulationOfLipidBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","lipids","."),4029339). assertion_content_comment('tOboGo_NegativeRegulationOfLipidCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lipids","."),4037982). assertion_content_comment('tOboGo_NegativeRegulationOfLipidKinaseActivity',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","lipid","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","simple","or","complex","lipid","."),4155565). assertion_content_comment('tOboGo_NegativeRegulationOfLipidMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","lipids","."),4029311). assertion_content_comment('tOboGo_NegativeRegulationOfLipidStorage',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","lipid","storage",".","Lipid","storage","is","the","accumulation","and","maintenance","in","cells","or","tissues","of","lipids",",","compounds","soluble","in","organic","solvents","but","insoluble","or","sparingly","soluble","in","aqueous","solvents",".","Lipid","reserves","can","be","accumulated","during","early","developmental","stages","for","mobilization","and","utilization","at","later","stages","of","development","."),4037536). assertion_content_comment('tOboGo_NegativeRegulationOfLipidTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","lipids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4024845). assertion_content_comment('tOboGo_NegativeRegulationOfLipoproteinLipaseActivity',s("Any","process","that","stops","or","reduces","the","activity","of","the","enzyme","lipoprotein","lipase","."),4279150). assertion_content_comment('tOboGo_NegativeRegulationOfLipoproteinLipidOxidation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","lipoprotein","lipid","oxidation",".","Lipoprotein","lipid","oxidation","is","the","modification","of","a","lipoprotein","by","oxidation","of","the","lipid","group","."),4116888). assertion_content_comment('tOboGo_NegativeRegulationOfLipoproteinMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","lipoproteins",",","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids","."),4074912). assertion_content_comment('tOboGo_NegativeRegulationOfLipoproteinOxidation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lipoprotein","oxidation","."),4074920). assertion_content_comment('tOboGo_NegativeRegulationOfLipoproteinParticleClearance',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","lipoprotein","particle","clearance",".","Lipoprotein","particle","clearance","is","the","process","in","which","a","lipoprotein","particle","is","removed","from","the","blood","via","receptor-mediated","endocytosis","and","its","constituent","parts","degraded","."),4035776). assertion_content_comment('tOboGo_NegativeRegulationOfLocomotionInvolvedInLocomotoryBehavior',s("Any","process","that","decreases","the","frequency",",","rate",",","or","extent","of","the","self-propelled","movement","of","a","cell","or","organism","from","one","location","to","another","in","a","behavioral","context",";","the","aspect","of","locomotory","behavior","having","to","do","with","movement","."),4150556). assertion_content_comment('tOboGo_NegativeRegulationOfLocomotion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","locomotion","of","a","cell","or","organism","."),3998020). assertion_content_comment('tOboGo_NegativeRegulationOfLuteinizingHormoneSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","luteinizing","hormone","."),4063048). assertion_content_comment('tOboGo_NegativeRegulationOfLyaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","lyase","activity",",","the","catalysis","of","the","cleavage","of","C-C",",","C-O",",","C-N","and","other","bonds","by","other","means","than","by","hydrolysis","or","oxidation",",","or","conversely","adding","a","group","to","a","double","bond","."),4152956). assertion_content_comment('tOboGo_NegativeRegulationOfLymphocyteActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lymphocyte","activation","."),3989372). assertion_content_comment('tOboGo_NegativeRegulationOfLymphocyteAnergy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","lymphocyte","anergy","."),3998336). assertion_content_comment('tOboGo_NegativeRegulationOfLymphocyteApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lymphocyte","death","by","apoptosis","."),3999572). assertion_content_comment('tOboGo_NegativeRegulationOfLymphocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lymphocyte","differentiation","."),3989379). assertion_content_comment('tOboGo_NegativeRegulationOfLymphocyteMediatedImmunity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","lymphocyte","mediated","immunity","."),3983942). assertion_content_comment('tOboGo_NegativeRegulationOfLymphocyteMigration',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","lymphocyte","migration","."),4142223). assertion_content_comment('tOboGo_NegativeRegulationOfLymphocyteProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","lymphocyte","proliferation","."),4062091). assertion_content_comment('tOboGo_NegativeRegulationOfLymphotoxinABiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","cytokine","lymphotoxin","A","."),4094006). assertion_content_comment('tOboGo_NegativeRegulationOfLymphotoxinAProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","lymphotoxin","A","production","."),4068366). assertion_content_comment('tOboGo_NegativeRegulationOfLysineImport',s("Any","process","that","decreases","the","rate","or","frequency","of","lysine","import",".","Lysine","import","is","the","directed","movement","of","lysine",",","2",",","6-diaminohexanoic","acid",",","into","a","cell","or","organelle","."),4025992). assertion_content_comment('tOboGo_NegativeRegulationOfMacroautophagy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","macroautophagy","."),4034060). assertion_content_comment('tOboGo_NegativeRegulationOfMacromoleculeBiosyntheticProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","macromolecule",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3971608). assertion_content_comment('tOboGo_NegativeRegulationOfMacromoleculeMetabolicProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","macromolecules",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3971493). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","macrophage","activation","."),4094067). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","macrophage","antigen","processing","and","presentation","."),3994568). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","macrophage","apoptosis","."),4138406). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageChemotaxis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","macrophage","chemotaxis",".","Macrophage","chemotaxis","is","the","movement","of","a","macrophage","in","response","to","an","external","stimulus","."),4024985). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageCytokineProduction',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","macrophage","cytokine","production",".","Macrophage","cytokine","production","is","the","appearance","of","a","chemokine","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4034931). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageDerivedFoamCellDifferentiation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","macrophage","derived","foam","cell","differentiation",".","Macrophage","derived","foam","cell","differentiation","is","the","process","in","which","a","macrophage","acquires","the","specialized","features","of","a","foam","cell",".","A","foam","cell","is","a","type","of","cell","containing","lipids","in","small","vacuoles","and","typically","seen","in","atherosclerotic","lesions",",","as","well","as","other","conditions","."),4024675). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","macrophage","differentiation","."),4087728). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageFusion',s("Any","process","that","stops",",","prevents",",","or","decreases","the","frequency",",","rate","or","extent","of","macrophage","fusion","."),4075733). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageInflammatoryProtein1AlphaProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","production","of","macrophage","inflammatory","protein","1","alpha","."),4130127). assertion_content_comment('tOboGo_NegativeRegulationOfMacrophageMigrationInhibitoryFactorSignalingPathway',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","macrophage","migration","inhibitory","factor","signaling","pathway","."),4142369). assertion_content_comment('tOboGo_NegativeRegulationOfMaintenanceOfBipolarCellPolarityRegulatingInCellShape',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","maintenance","of","bipolar","cell","polarity","regulating","cell","shape","."),4133723). assertion_content_comment('tOboGo_NegativeRegulationOfMaintenanceOfMeioticSisterChromatidCohesion',s("Any","process","that","decreases","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","during","a","meiotic","cell","cycle","."),4077039). assertion_content_comment('tOboGo_NegativeRegulationOfMaintenanceOfMitoticSisterChromatidCohesion',s("Any","process","that","decreases","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","during","a","mitotic","cell","cycle","."),4076086). assertion_content_comment('tOboGo_NegativeRegulationOfMaintenanceOfSisterChromatidCohesion',s("Any","process","that","decreases","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","."),4076082). assertion_content_comment('tOboGo_NegativeRegulationOfMaleGermCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","male","germ","cell","proliferation","."),4140357). assertion_content_comment('tOboGo_NegativeRegulationOfMaleGonadDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","male","gonad","development","."),4139432). assertion_content_comment('tOboGo_NegativeRegulationOfMalePigmentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","males","."),4104332). assertion_content_comment('tOboGo_NegativeRegulationOfMammaryGlandDevelopmentInMalesByAndrogenReceptorSignalingPathway',s("Any","process","that","decreases","the","rate","or","extent","of","mammary","gland","development","in","the","male","by","an","androgen","binding","to","its","receptor",",","causing","a","change","in","state","or","activity","of","a","cell","."),4111941). assertion_content_comment('tOboGo_NegativeRegulationOfMammaryGlandEpithelialCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","mammary","gland","epithelial","cell","proliferation","."),4063487). assertion_content_comment('tOboGo_NegativeRegulationOfMammaryStemCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mammary","stem","cell","proliferation","."),4138436). assertion_content_comment('tOboGo_NegativeRegulationOfMAPKinaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","MAP","kinase","activity","."),3972890). assertion_content_comment('tOboGo_NegativeRegulationOfMAPKKKCascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","MAPKKK","cascade","."),4070244). assertion_content_comment('tOboGo_NegativeRegulationOfMastCellActivationInvolvedInImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","mast","cell","activation","as","part","of","an","immune","response","."),4065254). assertion_content_comment('tOboGo_NegativeRegulationOfMastCellActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","mast","cell","activation","."),4065206). assertion_content_comment('tOboGo_NegativeRegulationOfMastCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","mast","cell","apoptosis","."),4065141). assertion_content_comment('tOboGo_NegativeRegulationOfMastCellChemotaxis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","mast","cell","chemotaxis",".","Mast","cell","chemotaxis","is","the","movement","of","a","mast","cell","in","response","to","an","external","stimulus","."),4110462). assertion_content_comment('tOboGo_NegativeRegulationOfMastCellCytokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","mast","cell","cytokine","production","."),4068967). assertion_content_comment('tOboGo_NegativeRegulationOfMastCellDegranulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","mast","cell","degranulation","."),4093678). assertion_content_comment('tOboGo_NegativeRegulationOfMastCellDifferentiation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","mast","cell","differentiation",",","the","process","in","which","a","relatively","unspecialized","myeloid","precursor","cell","acquires","the","specialized","features","of","a","mast","cell",".","A","mast","cell","is","a","cell","that","is","found","in","almost","all","tissues","containing","numerous","basophilic","granules","and","capable","of","releasing","large","amounts","of","histamine","and","heparin","upon","activation","."),4114988). assertion_content_comment('tOboGo_NegativeRegulationOfMastCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","mast","cell","proliferation","."),4130468). assertion_content_comment('tOboGo_NegativeRegulationOfMatingTypeSwitching',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mating","type","switching","."),4060848). assertion_content_comment('tOboGo_NegativeRegulationOfMatureBCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","mature","B","cell","apoptosis","."),3999615). assertion_content_comment('tOboGo_NegativeRegulationOfMechanoreceptorDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mechanoreceptor","differentiation","."),4086842). assertion_content_comment('tOboGo_NegativeRegulationOfMegakaryocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","megakaryocyte","differentiation","."),4087779). assertion_content_comment('tOboGo_NegativeRegulationOfMeiosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","meiosis","."),4086478). assertion_content_comment('tOboGo_NegativeRegulationOfMeioticCellCycle',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","progression","through","the","meiotic","cell","cycle","."),4118353). assertion_content_comment('tOboGo_NegativeRegulationOfMeioticJointMoleculeFormation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","meiotic","joint","molecule","formation",".","Meiotic","joint","molecule","formation","is","the","conversion","of","the","paired","broken","DNA","and","homologous","duplex","DNA","into","a","four-stranded","branched","intermediate",",","known","as","a","joint","molecule",",","formed","during","meiotic","recombination","."),4034868). assertion_content_comment('tOboGo_NegativeRegulationOfMelaninBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","melanin","."),4104531). assertion_content_comment('tOboGo_NegativeRegulationOfMelanizationDefenseResponse',s("Any","process","that","reduces","the","rate","or","extent","of","the","melanization","defense","response",".","This","regulation","is","critical","to","limit","melanization","to","the","site","of","injury","or","infection","."),4072485). assertion_content_comment('tOboGo_NegativeRegulationOfMelanocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","melanocyte","differentiation","."),4087045). assertion_content_comment('tOboGo_NegativeRegulationOfMembranePotential',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","or","extent","of","a","membrane","potential",",","the","electric","potential","existing","across","any","membrane","arising","from","charges","in","the","membrane","itself","and","from","the","charges","present","in","the","media","on","either","side","of","the","membrane","."),4155205). assertion_content_comment('tOboGo_NegativeRegulationOfMembraneProteinEctodomainProteolysis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","membrane","protein","ectodomain","proteolysis","."),4119254). assertion_content_comment('tOboGo_NegativeRegulationOfMemoryTCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","memory","T","cell","differentiation","."),4095881). assertion_content_comment('tOboGo_NegativeRegulationOfMesenchymalCellProliferationInvolvedInUreterDevelopment',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","mesenchymal","cell","proliferation","that","contributes","to","the","progression","of","the","ureter","gland","over","time",".","A","mesenchymal","cell","is","a","cell","that","normally","gives","rise","to","other","cells","that","are","organized","as","three-dimensional","masses",",","rather","than","sheets","."),4124869). assertion_content_comment('tOboGo_NegativeRegulationOfMesenchymalCellProliferation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","mesenchymal","cell","proliferation",".","A","mesenchymal","cell","is","a","cell","that","normally","gives","rise","to","other","cells","that","are","organized","as","three-dimensional","masses",",","rather","than","sheets","."),4124833). assertion_content_comment('tOboGo_NegativeRegulationOfMesenchymalStemCellApoptosisInvolvedInMesonephricNephronMorphogenesis',s("Any","process","that","reduces","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephron","in","the","mesonephros","."),4134699). assertion_content_comment('tOboGo_NegativeRegulationOfMesenchymalStemCellApoptosisInvolvedInMetanephricNephronMorphogenesis',s("Any","process","that","reduces","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephron","in","the","metanephros","."),4124659). assertion_content_comment('tOboGo_NegativeRegulationOfMesenchymalStemCellApoptosisInvolvedInNephronMorphogenesis',s("Any","process","that","reduces","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephron","."),4123603). assertion_content_comment('tOboGo_NegativeRegulationOfMesenchymalToEpithelialTransitionInvolvedInMesonephrosMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mesenchymal","to","epithelial","transition","involved","in","mesonephros","morphogenesis","."),4138287). assertion_content_comment('tOboGo_NegativeRegulationOfMesenchymalToEpithelialTransitionInvolvedInMetanephrosMorphogenesis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","that","will","contribute","to","the","shaping","of","the","metanephros","."),4006239). assertion_content_comment('tOboGo_NegativeRegulationOfMesodermalCellFateDetermination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mesoderm","cell","fate","determination","."),4102135). assertion_content_comment('tOboGo_NegativeRegulationOfMesodermalCellFateSpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mesoderm","cell","fate","specification","."),4078103). assertion_content_comment('tOboGo_NegativeRegulationOfMesodermDevelopment',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","mesoderm","development","."),4143052). assertion_content_comment('tOboGo_NegativeRegulationOfMesonephricGlomerularMesangialCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mesonephric","glomerular","mesangial","cell","proliferation","."),4138206). assertion_content_comment('tOboGo_NegativeRegulationOfMesonephricGlomerulusDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mesonephric","glomerulus","development","."),4138239). assertion_content_comment('tOboGo_NegativeRegulationOfMesonephricNephronTubuleEpithelialCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mesonephric","nephron","tubule","epithelial","cell","differentiation","."),4138151). assertion_content_comment('tOboGo_NegativeRegulationOfMesonephrosDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","mesonephros","development",".","Mesonephros","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephros","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4134694). assertion_content_comment('tOboGo_NegativeRegulationOfMetabolicActivityInvolvedInHibernation',s("The","slowing","of","metabolic","processes","to","very","low","levels","in","order","to","conserve","energy","as","a","part","of","hibernation","."),4097975). assertion_content_comment('tOboGo_NegativeRegulationOfMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","within","a","cell","or","an","organism","."),3971484). assertion_content_comment('tOboGo_NegativeRegulationOfMetalloenzymeActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","activity","of","a","metalloenzyme",".","A","metalloenzyme","is","any","enzyme","that","contains","metal","."),4332322). assertion_content_comment('tOboGo_NegativeRegulationOfMetanephricDCTCellDifferentiation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","metanephric","DCT","cell","differentiation","."),4144442). assertion_content_comment('tOboGo_NegativeRegulationOfMetanephricGlomerularMesangialCellProliferation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","metanephric","glomerular","mesangial","cell","proliferation","."),4124616). assertion_content_comment('tOboGo_NegativeRegulationOfMetanephricGlomerulusDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","metanephric","glomerulus","development",",","the","progression","of","the","metanephric","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","metanephric","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney",",","or","metanephros","."),4124594). assertion_content_comment('tOboGo_NegativeRegulationOfMetanephricMesenchymalCellMigration',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","metanephric","mesenchymal","cell","migration","."),4144556). assertion_content_comment('tOboGo_NegativeRegulationOfMetanephricNephronTubuleEpithelialCellDifferentiation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","metanephric","nephron","tubule","epithelial","cell","differentiation","."),4124681). assertion_content_comment('tOboGo_NegativeRegulationOfMetanephrosDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","metanephros","development",".","Metanephros","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephros","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4124578). assertion_content_comment('tOboGo_NegativeRegulationOfMetulaDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","metula","development",",","a","process","that","leads","to","the","formation","of","metulae",".","Metulae","are","elongated","mononucleate","cells","that","bud","from","the","surface","of","the","conidiophore","tip","."),4132572). assertion_content_comment('tOboGo_NegativeRegulationOfMHCClassIBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","MHC","class","I","."),4085941). assertion_content_comment('tOboGo_NegativeRegulationOfMHCClassIIBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","MHC","class","II","."),4085898). assertion_content_comment('tOboGo_NegativeRegulationOfMicrogliaDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","microglia","differentiation",",","the","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","microglial","cell","."),4036413). assertion_content_comment('tOboGo_NegativeRegulationOfMicrotubuleDepolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","microtubule","depolymerization",";","prevention","of","depolymerization","of","a","microtubule","can","result","from","binding","by","'","capping","'","at","the","plus","end","(","e.g",".","by","interaction","with","another","cellular","protein","of","structure",")","or","by","exposing","microtubules","to","a","stabilizing","drug","such","as","taxol","."),4013312). assertion_content_comment('tOboGo_NegativeRegulationOfMicrotubuleMotorActivity',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","microtubule","motor","activity","."),4155752). assertion_content_comment('tOboGo_NegativeRegulationOfMicrotubulePolymerizationOrDepolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","microtubule","polymerization","or","depolymerization","."),4013276). assertion_content_comment('tOboGo_NegativeRegulationOfMicrotubulePolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","microtubule","polymerization","."),4062630). assertion_content_comment('tOboGo_NegativeRegulationOfMiRNACatabolicProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","miRNA","catabolic","process","."),4144112). assertion_content_comment('tOboGo_NegativeRegulationOfMiRNAMetabolicProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","miRNA","metabolic","process","."),4144051). assertion_content_comment('tOboGo_NegativeRegulationOfMismatchRepair',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mismatch","repair","."),4055687). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialDepolarization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","change","in","the","membrane","potential","of","the","mitochondria","from","negative","to","positive","."),4120189). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialDNAReplication',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","process","in","which","new","strands","of","DNA","are","synthesized","in","the","mitochondrion","."),4152094). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialFission',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","mitochondrial","fission",".","Mitochondrial","fission","is","the","division","of","a","mitochondrion","within","a","cell","to","form","two","or","more","separate","mitochondrial","compartments","."),4151939). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialFusion',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","merging","of","two","or","more","mitochondria","within","a","cell","to","form","a","single","compartment","."),4028750). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialMembranePermeability',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","passage","or","uptake","of","molecules","by","the","mitochondrial","membrane","."),4381310). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialMembranePotential',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","establishment","or","extent","of","a","mitochondrial","membrane","potential",",","the","electric","potential","existing","across","any","mitochondrial","membrane","arising","from","charges","in","the","membrane","itself","and","from","the","charges","present","in","the","media","on","either","side","of","the","membrane","."),4336069). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialRNACatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","catabolism","in","the","mitochondrion","of","RNA","transcribed","from","the","mitochondrial","genome","."),3979648). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialTranslationalInitiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","process","preceding","formation","of","the","peptide","bond","between","the","first","two","amino","acids","of","a","protein","in","a","mitochondrion","."),4133359). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrialTranslation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","proteins","by","the","translation","of","mRNA","in","a","mitochondrion","."),4133215). assertion_content_comment('tOboGo_NegativeRegulationOfMitochondrionOrganization',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","mitochondrion","."),4028746). assertion_content_comment('tOboGo_NegativeRegulationOfMitosis',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","mitosis",".","Mitosis","is","the","division","of","the","eukaryotic","cell","nucleus","to","produce","two","daughter","nuclei","that",",","usually",",","contain","the","identical","chromosome","complement","to","their","mother","."),4090157). assertion_content_comment('tOboGo_NegativeRegulationOfMitoticCellCycleEmbryonic',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","progression","through","the","embryonic","mitotic","cell","cycle","."),4091994). assertion_content_comment('tOboGo_NegativeRegulationOfMitoticCellCycle',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","progression","through","the","mitotic","cell","cycle","."),4035441). assertion_content_comment('tOboGo_NegativeRegulationOfMitoticCentrosomeSeparation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","centrosome","separation","."),4098719). assertion_content_comment('tOboGo_NegativeRegulationOfMitoticMetaphaseAnaphaseTransition',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","mitotic","metaphase","to","anaphase","transition","."),4090164). assertion_content_comment('tOboGo_NegativeRegulationOfMitoticPrometaphase',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","mitotic","prometaphase",",","the","stage","following","prophase","in","mitosis","(","in","higher","eukaryotes",")","during","which","the","nuclear","envelope","is","disrupted","and","breaks","into","membrane","vesicles",",","and","the","spindle","microtubules","enter","the","nuclear","region","."),4082957). assertion_content_comment('tOboGo_NegativeRegulationOfMitoticRecombination',s("Any","process","that","inhibits","or","decreases","the","rate","of","DNA","recombination","during","mitosis","."),4055208). assertion_content_comment('tOboGo_NegativeRegulationOfMitoticSisterChromatidSegregation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sister","chromatid","segregation","during","mitosis","."),4064997). assertion_content_comment('tOboGo_NegativeRegulationOfMolecularFunctionEpigenetic',s("Any","heritable","epigenetic","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","function","by","self-perpetuating","conformational","conversions","of","normal","proteins","in","healthy","cells",".","This","is","distinct","from",",","though","mechanistically","analogous","to",",","disease","states","associated","with","prion","propagation","and","amyloidogenesis",".","A","single","protein",",","if","it","carries","a","glutamine/asparagine-rich","(","'","prion","'",")","domain",",","can","sometimes","stably","exist","in","at","least","two","distinct","physical","states",",","each","associated","with","a","different","phenotype",";","propagation","of","one","of","these","traits","is","achieved","by","a","self-perpetuating","change","in","the","protein","from","one","form","to","the","other",",","mediated","by","conformational","changes","in","the","glutamine/asparagine-rich","domain",".","Prion","domains","are","both","modular","and","transferable","to","other","proteins",",","on","which","they","can","confer","a","heritable","epigenetic","alteration","of","function",";","existing","bioinformatics","data","indicate","that","they","are","rare","in","non-eukarya",",","but","common","in","eukarya","."),4298133). assertion_content_comment('tOboGo_NegativeRegulationOfMolecularFunctionInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","functional","activity","of","proteins","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4153025). assertion_content_comment('tOboGo_NegativeRegulationOfMolecularFunction',s("Any","process","that","stops","or","reduces","the","rate","or","extent","of","a","molecular","function",",","an","elemental","biological","activity","occurring","at","the","molecular","level",",","such","as","catalysis","or","binding","."),3972855). assertion_content_comment('tOboGo_NegativeRegulationOfMonocyteAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","monocyte","antigen","processing","and","presentation","."),3994618). assertion_content_comment('tOboGo_NegativeRegulationOfMonocyteChemotaxis',s("Any","process","that","decreases","the","frequency",",","rate",",","or","extent","of","monocyte","chemotaxis","."),4149860). assertion_content_comment('tOboGo_NegativeRegulationOfMonocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","monocyte","differentiation","."),4087794). assertion_content_comment('tOboGo_NegativeRegulationOfMonocyteExtravasation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","monocyte","extravasation","."),4142047). assertion_content_comment('tOboGo_NegativeRegulationOfMononuclearCellMigration',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","mononuclear","cell","migration",".","Mononuclear","cell","migration","is","the","movement","of","a","mononuclear","cell","within","or","between","different","tissues","and","organs","of","the","body","."),4128993). assertion_content_comment('tOboGo_NegativeRegulationOfMononuclearCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mononuclear","cell","proliferation","."),4062084). assertion_content_comment('tOboGo_NegativeRegulationOfMonooxygenaseActivity',s("Any","process","that","stops","or","reduces","the","activity","of","a","monooxygenase","."),4279087). assertion_content_comment('tOboGo_NegativeRegulationOfMonophenolMonooxygenaseActivity',s("Any","process","that","stops","or","reduces","the","activity","of","the","enzyme","monophenol","monooxygenase",".","Monophenol","monooxygenase","catalyzes","the","reaction",":","L-tyrosine","+","L-DOPA","+","O2","=","L-DOPA","+","DOPAquinone","+","H2O","."),4337512). assertion_content_comment('tOboGo_NegativeRegulationOfMonopolarCellGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","monopolar","cell","growth",",","polarized","growth","from","one","end","of","a","cell","."),4118702). assertion_content_comment('tOboGo_NegativeRegulationOfMRNACleavage',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mRNA","cleavage","."),4058436). assertion_content_comment('tOboGo_NegativeRegulationOfMRNAModification',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","covalent","alteration","of","one","or","more","nucleotides","within","an","mRNA","molecule","to","produce","an","mRNA","molecule","with","a","sequence","that","differs","from","that","coded","genetically","."),4150974). assertion_content_comment('tOboGo_NegativeRegulationOfMRNAProcessing',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","mRNA","processing","."),4058286). assertion_content_comment('tOboGo_NegativeRegulationOfMucusSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","mucus","from","a","cell","or","group","of","cells","."),4137172). assertion_content_comment('tOboGo_NegativeRegulationOfMulticellularOrganismalMetabolicProcess',s("Any","process","that","stops",",","prevents","or","reduces","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","in","multicellular","organisms","that","occur","at","the","tissue",",","organ",",","or","organismal","level","."),4026888). assertion_content_comment('tOboGo_NegativeRegulationOfMulticellularOrganismalProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","an","organismal","process",",","the","processes","pertinent","to","the","function","of","an","organism","above","the","cellular","level",";","includes","the","integrated","processes","of","tissues","and","organs","."),3984412). assertion_content_comment('tOboGo_NegativeRegulationOfMulticellularOrganismGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","growth","of","an","organism","to","reach","its","usual","body","size","."),4081679). assertion_content_comment('tOboGo_NegativeRegulationOfMuscleAdaptation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","muscle","adaptation","."),4028836). assertion_content_comment('tOboGo_NegativeRegulationOfMuscleAtrophy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","muscle","atrophy","."),4040377). assertion_content_comment('tOboGo_NegativeRegulationOfMuscleCellApoptosis',s("Any","process","that","decreases","the","rate","or","frequency","of","muscle","cell","apoptosis",".","Muscle","cell","apoptosis","is","a","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","muscle","cell","and","result","in","its","death","."),4026245). assertion_content_comment('tOboGo_NegativeRegulationOfMuscleCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","muscle","cell","differentiation","."),4036711). assertion_content_comment('tOboGo_NegativeRegulationOfMuscleContraction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","muscle","contraction","."),4040051). assertion_content_comment('tOboGo_NegativeRegulationOfMuscleHyperplasia',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","muscle","hyperplasia","."),4039996). assertion_content_comment('tOboGo_NegativeRegulationOfMuscleHypertrophy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","muscle","hypertrophy","."),4028791). assertion_content_comment('tOboGo_NegativeRegulationOfMuscleOrganDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","muscle","development","."),4039832). assertion_content_comment('tOboGo_NegativeRegulationOfMyelination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","formation","of","a","myelin","sheath","around","nerve","axons","."),4059880). assertion_content_comment('tOboGo_NegativeRegulationOfMyeloidCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","myeloid","cell","apoptosis","."),4065034). assertion_content_comment('tOboGo_NegativeRegulationOfMyeloidCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","myeloid","cell","differentiation","."),3996728). assertion_content_comment('tOboGo_NegativeRegulationOfMyeloidDendriticCellActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","myeloid","dendritic","cell","activation","."),4061894). assertion_content_comment('tOboGo_NegativeRegulationOfMyeloidDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","myeloid","dendritic","cell","antigen","processing","and","presentation","."),3994759). assertion_content_comment('tOboGo_NegativeRegulationOfMyeloidDendriticCellChemotaxis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","myeloid","dendritic","cell","chemotaxis","."),4144684). assertion_content_comment('tOboGo_NegativeRegulationOfMyeloidDendriticCellCytokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","myeloid","dendritic","cell","cytokine","production","."),3998766). assertion_content_comment('tOboGo_NegativeRegulationOfMyeloidLeukocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","myeloid","leukocyte","differentiation","."),3996735). assertion_content_comment('tOboGo_NegativeRegulationOfMyeloidLeukocyteMediatedImmunity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","myeloid","leukocyte","mediated","immunity","."),3983912). assertion_content_comment('tOboGo_NegativeRegulationOfMyoblastDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","myoblast","differentiation",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4087383). assertion_content_comment('tOboGo_NegativeRegulationOfMyosinLightChainKinaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","myosin","light","chain","kinase","activity","."),4379228). assertion_content_comment('tOboGo_NegativeRegulationOfMyotubeDifferentiation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","myotube","differentiation",".","Myotube","differentiation","is","the","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","myotube","cell",".","Myotubes","are","multinucleated","cells","that","are","formed","when","proliferating","myoblasts","exit","the","cell","cycle",",","differentiate","and","fuse","."),4036726). assertion_content_comment('tOboGo_NegativeRegulationOfNADKinaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","NAD","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","an","NAD","molecule","."),4341287). assertion_content_comment('tOboGo_NegativeRegulationOfNADPHOxidaseActivity',s("Any","process","that","stops","or","reduces","the","activity","of","the","enzyme","NAD","(","P",")","H","oxidase","."),4343676). assertion_content_comment('tOboGo_NegativeRegulationOfNatriuresis',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","decreases","the","frequency",",","rate",",","or","extent","of","natriuresis",",","the","process","of","renal","sodium","excretion","."),4193937). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","cell","activation","."),4070643). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","cell","death","by","apoptosis","."),4137105). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellChemotaxis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","cell","chemotaxis","."),4145695). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellCytokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","cytokine","production","."),3998682). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellDegranulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","natural","killer","cell","degranulation","."),4095526). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellDifferentiationInvolvedInImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","cell","differentiation","as","part","of","an","immune","response","."),4070764). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","cell","differentiation","."),4070738). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellMediatedCytotoxicityDirectedAgainstTumorCellTarget',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","cytotoxicity","directed","against","tumor","cell","target","."),4000126). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellMediatedCytotoxicity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","natural","killer","mediated","cytotoxicity","."),4000112). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellMediatedImmuneResponseToTumorCell',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","immune","response","to","a","tumor","cell","."),4000064). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellMediatedImmunity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","immunity","."),3998670). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellProliferationInvolvedInImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","cell","proliferation","as","part","of","an","immune","response","."),4070822). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","cell","proliferation","."),4070653). assertion_content_comment('tOboGo_NegativeRegulationOfNaturalKillerCellToleranceInduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","tolerance","induction","."),4000695). assertion_content_comment('tOboGo_NegativeRegulationOfNecroptosis',s("Any","process","that","decreases","the","rate","frequency","or","extent","of","necroptosis",".","Necroptosis","is","a","necrotic","cell","death","process","that","results","from","the","activation","of","endogenous","cellular","processes",",","such","as","signaling","involving","death","domain","receptors","and","Toll-like","receptors","."),4116478). assertion_content_comment('tOboGo_NegativeRegulationOfNecroticCellDeath',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","necrotic","cell","death",".","Necrotic","cell","death","is","a","cell","death","process","that","is","morphologically","characterized","by","a","gain","in","cell","volume","(","oncosis",")",",","swelling","of","organelles",",","plasma","membrane","rupture","and","subsequent","loss","of","intracellular","contents","."),4116380). assertion_content_comment('tOboGo_NegativeRegulationOfNegativeChemotaxis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","in","a","concentration","gradient","of","a","specific","chemical","."),4100247). assertion_content_comment('tOboGo_NegativeRegulationOfNematodeLarvalDevelopment',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","nematode","larval","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","nematode","larva","over","time",",","from","its","formation","to","the","mature","structure",".","Nematode","larval","development","begins","with","the","newly","hatched","first-stage","larva","(","L1",")","and","ends","with","the","end","of","the","last","larval","stage","(","for","example","the","fourth","larval","stage","(","L4",")","in","C",".","elegans",")","Each","stage","of","nematode","larval","development","is","characterized","by","proliferation","of","specific","cell","lineages","and","an","increase","in","body","size","without","alteration","of","the","basic","body","plan",".","Nematode","larval","stages","are","separated","by","molts","in","which","each","stage-specific","exoskeleton",",","or","cuticle",",","is","shed","and","replaced","anew","."),4081905). assertion_content_comment('tOboGo_NegativeRegulationOfNephronTubuleEpithelialCellDifferentiation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","nephron","tubule","epithelial","cell","differentiation","."),4123465). assertion_content_comment('tOboGo_NegativeRegulationOfNerveGrowthFactorProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","production","of","nerve","growth","factor","."),4064586). assertion_content_comment('tOboGo_NegativeRegulationOfNerveGrowthFactorReceptorActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","activity","of","the","nerve","growth","factor","receptor","."),4286315). assertion_content_comment('tOboGo_NegativeRegulationOfNerveGrowthFactorReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","activity","of","the","nerve","growth","factor","receptor","signaling","pathway","."),4118289). assertion_content_comment('tOboGo_NegativeRegulationOfNervousSystemDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","nervous","system","development",",","the","origin","and","formation","of","nervous","tissue","."),4053206). assertion_content_comment('tOboGo_NegativeRegulationOfNeuralCrestFormation',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","neural","crest","formation",".","Neural","crest","formation","is","the","formation","of","the","specialized","region","of","ectoderm","between","the","neural","ectoderm","(","neural","plate",")","and","non-neural","ectoderm",".","The","neural","crest","gives","rise","to","the","neural","crest","cells","that","migrate","away","from","this","region","as","neural","tube","formation","procedes","."),4152047). assertion_content_comment('tOboGo_NegativeRegulationOfNeuralPrecursorCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","neural","precursor","cell","proliferation","."),4019632). assertion_content_comment('tOboGo_NegativeRegulationOfNeuralRetinaDevelopment',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","neural","retina","development",",","the","progression","of","the","neural","retina","over","time","from","its","initial","formation","to","the","mature","structure",".","The","neural","retina","is","the","part","of","the","retina","that","contains","neurons","and","photoreceptor","cells","."),4135255). assertion_content_comment('tOboGo_NegativeRegulationOfNeuroblastProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","proliferation","of","neuroblasts","."),4019635). assertion_content_comment('tOboGo_NegativeRegulationOfNeurogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","neurogenesis",",","the","origin","and","formation","of","neurons","."),4019617). assertion_content_comment('tOboGo_NegativeRegulationOfNeurologicalSystemProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","neurophysiological","process","."),4054239). assertion_content_comment('tOboGo_NegativeRegulationOfNeuronApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cell","death","by","apoptosis","in","neurons","."),4064505). assertion_content_comment('tOboGo_NegativeRegulationOfNeuronDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","neuron","differentiation","."),4086835). assertion_content_comment('tOboGo_NegativeRegulationOfNeuronMaturation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","neuron","maturation","."),4039607). assertion_content_comment('tOboGo_NegativeRegulationOfNeuronProjectionDevelopment',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","neuron","projection","development",".","Neuron","projection","development","is","the","process","whose","specific","outcome","is","the","progression","of","a","neuron","projection","over","time",",","from","its","formation","to","the","mature","structure",".","A","neuron","projection","is","any","process","extending","from","a","neural","cell",",","such","as","axons","or","dendrites","(","collectively","called","neurites",")"),4035813). assertion_content_comment('tOboGo_NegativeRegulationOfNeuronProjectionRegeneration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","neuron","projection","regeneration",",","the","regrowth","of","neuronal","processes","such","as","axons","or","dendrites","following","their","loss","or","damage","."),4106851). assertion_content_comment('tOboGo_NegativeRegulationOfNeurotransmitterSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","neurotransmitter","."),4039500). assertion_content_comment('tOboGo_NegativeRegulationOfNeurotransmitterTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","neurotransmitter","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4039493). assertion_content_comment('tOboGo_NegativeRegulationOfNeurotransmitterUptake',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","neurotransmitter","into","a","neuron","or","glial","cell","."),4120395). assertion_content_comment('tOboGo_NegativeRegulationOfNeurotrophinProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","production","of","a","neurotrophin","."),4064534). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilAggregation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","neutrophil","aggregation","."),4141737). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","neutrophil","apoptosis","."),4065077). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilChemotaxis',s("Any","process","that","decreases","the","frequency",",","rate",",","or","extent","of","neutrophil","chemotaxis",".","Neutrophil","chemotaxis","is","the","directed","movement","of","a","neutrophil","cell",",","the","most","numerous","polymorphonuclear","leukocyte","found","in","the","blood",",","in","response","to","an","external","stimulus",",","usually","an","infection","or","wounding","."),4149882). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilDegranulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","neutrophil","degranulation","."),4093648). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","neutrophil","differentiation","."),4087342). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilExtravasation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","neutrophil","extravasation","."),4142596). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilMediatedCytotoxicity',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","target","cell","by","a","neutrophil","."),4131829). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilMediatedKillingOfBacterium',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","bacterium","by","a","neutrophil","."),4131844). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilMediatedKillingOfFungus',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","fungal","cell","by","a","neutrophil","."),4131881). assertion_content_comment('tOboGo_NegativeRegulationOfNeutrophilMediatedKillingOfSymbiontCell',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","symbiont","target","cell","by","a","neutrophil","."),4131837). assertion_content_comment('tOboGo_NegativeRegulationOfNFATProteinImportIntoNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","movement","of","an","NFAT","protein","from","the","cytoplasm","to","the","nucleus","."),4118633). assertion_content_comment('tOboGo_NegativeRegulationOfNitricOxideBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","nitric","oxide","."),4097171). assertion_content_comment('tOboGo_NegativeRegulationOfNitricOxideMediatedSignalTransduction',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","nitric","oxide","mediated","signal","transduction",".","Nitric","oxide","mediated","signal","transduction","is","a","series","of","molecular","signals","mediated","by","the","detection","of","nitric","oxide","(","NO",")"),4024779). assertion_content_comment('tOboGo_NegativeRegulationOfNitrogenCompoundMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nitrogen","or","nitrogenous","compounds","."),3971545). assertion_content_comment('tOboGo_NegativeRegulationOfNitrogenUtilization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","nitrogen","utilization","."),4090209). assertion_content_comment('tOboGo_NegativeRegulationOfNKTCellActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","activation","."),4119427). assertion_content_comment('tOboGo_NegativeRegulationOfNKTCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","differentiation","."),4119911). assertion_content_comment('tOboGo_NegativeRegulationOfNKTCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","proliferation","."),4119844). assertion_content_comment('tOboGo_NegativeRegulationOfNorepinephrineSecretion',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","norepinephrine","."),4026729). assertion_content_comment('tOboGo_NegativeRegulationOfNorepinephrineUptake',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","norepinephrine","into","a","cell","."),4121743). assertion_content_comment('tOboGo_NegativeRegulationOfNotchSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","Notch","signaling","pathway","."),4091059). assertion_content_comment('tOboGo_NegativeRegulationOfNuclearDivision',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","nuclear","division",",","the","partitioning","of","the","nucleus","and","its","genetic","information","."),4090150). assertion_content_comment('tOboGo_NegativeRegulationOfNuclearMRNASplicingViaSpliceosome',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","mRNA","splicing","via","a","spliceosomal","mechanism","."),4104484). assertion_content_comment('tOboGo_NegativeRegulationOfNucleaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","nuclease","activity",",","the","hydrolysis","of","ester","linkages","within","nucleic","acids","."),4161248). assertion_content_comment('tOboGo_NegativeRegulationOfNucleobaseNucleosideNucleotideAndNucleicAcidMetabolicProcess',s("Any","cellular","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids","."),3971554). assertion_content_comment('tOboGo_NegativeRegulationOfNucleobaseNucleosideNucleotideAndNucleicAcidTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053727). assertion_content_comment('tOboGo_NegativeRegulationOfNucleocytoplasmicTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","between","the","cytoplasm","and","the","nucleus","."),4016376). assertion_content_comment('tOboGo_NegativeRegulationOfNucleosideMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleosides","."),4092250). assertion_content_comment('tOboGo_NegativeRegulationOfNucleosideTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","nucleoside","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053778). assertion_content_comment('tOboGo_NegativeRegulationOfNucleotideBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","nucleotides","."),4049829). assertion_content_comment('tOboGo_NegativeRegulationOfNucleotideCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nucleotides","."),4050457). assertion_content_comment('tOboGo_NegativeRegulationOfNucleotideMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleotides","."),4049801). assertion_content_comment('tOboGo_NegativeRegulationOfNurseCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","nurse","cell","apoptosis","."),4090180). assertion_content_comment('tOboGo_NegativeRegulationOfOctopamineOrTyramineSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","octopamine","or","tyramine","signaling","pathway","."),4137757). assertion_content_comment('tOboGo_NegativeRegulationOfOctopamineSignalingPathwayInvolvedInResponseToFood',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","octopamine","signaling","pathway","involved","in","response","to","food","."),4137768). assertion_content_comment('tOboGo_NegativeRegulationOfOctopamineSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","octopamine","signaling","pathway","."),4137763). assertion_content_comment('tOboGo_NegativeRegulationOfOdontogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","formation","and","development","of","a","tooth","or","teeth","."),4078555). assertion_content_comment('tOboGo_NegativeRegulationOfOligodendrocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","oligodendrocyte","differentiation","."),4107367). assertion_content_comment('tOboGo_NegativeRegulationOfOligodendrocyteProgenitorProliferation',s("Any","process","that","stops","or","decreases","the","rate","or","extent","of","oligodendrocyte","progenitor","proliferation","."),4136330). assertion_content_comment('tOboGo_NegativeRegulationOfOocyteDevelopment',s("Any","process","that","decreases","the","rate","or","extent","of","the","process","whose","specific","outcome","is","the","progression","of","an","oocyte","over","time",",","from","initial","commitment","of","the","cell","to","its","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4115832). assertion_content_comment('tOboGo_NegativeRegulationOfOogoniumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","oogonium","development",",","a","process","that","leads","to","the","formation","of","a","female","gametangium","of","oomycetes",",","containing","one","or","more","gametes","."),4148476). assertion_content_comment('tOboGo_NegativeRegulationOfOomyceteSporangiumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","oomycete","sporangium","development",",","a","process","that","leads","to","the","formation","of","oomycete","sporangium",",","a","single-celled","or","many-celled","structure","that","germinates","directly","to","form","an","infection","hypha","or","differentiate",",","through","specialized","cleavage","vesicles",",","into","between","10","and","30","zoospores",",","which","is","laterally","flagellated","."),4147998). assertion_content_comment('tOboGo_NegativeRegulationOfOosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","oospore","formation",",","a","process","in","which","male","and","female","gametangia","develop","and","fuse","to","form","a","thick-walled","resting","spore","of","oomycetes","."),4148645). assertion_content_comment('tOboGo_NegativeRegulationOfOpioidReceptorSignalingPathway',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","opioid","receptor","signaling","pathway","."),4145433). assertion_content_comment('tOboGo_NegativeRegulationOfOpticNerveFormation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","optic","nerve","formation","."),4144454). assertion_content_comment('tOboGo_NegativeRegulationOfOrganelleOrganization',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","organelle","."),3975685). assertion_content_comment('tOboGo_NegativeRegulationOfOrganGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","growth","of","an","organ","of","an","organism","."),4087961). assertion_content_comment('tOboGo_NegativeRegulationOfOrganicAcidTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","organic","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990715). assertion_content_comment('tOboGo_NegativeRegulationOfOskarMRNATranslation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","that","oskar","mRNAs","are","effectively","translated","into","protein","."),4235810). assertion_content_comment('tOboGo_NegativeRegulationOfOsteoclastDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","osteoclast","differentiation","."),4087434). assertion_content_comment('tOboGo_NegativeRegulationOfOvarianFollicleDevelopment',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","ovarian","follicle","development","."),4143492). assertion_content_comment('tOboGo_NegativeRegulationOfOvulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ovulation",",","the","release","of","a","mature","ovum/oocyte","from","an","ovary","."),4115820). assertion_content_comment('tOboGo_NegativeRegulationOfOxidativePhosphorylation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","phosphorylation","of","ADP","to","ATP","that","accompanies","the","oxidation","of","a","metabolite","through","the","operation","of","the","respiratory","chain",".","Oxidation","of","compounds","establishes","a","proton","gradient","across","the","membrane",",","providing","the","energy","for","ATP","synthesis","."),4155323). assertion_content_comment('tOboGo_NegativeRegulationOfOxidativePhosphorylationUncouplerActivity',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","oxidative","phosphorylation","uncoupler","activity","."),4169302). assertion_content_comment('tOboGo_NegativeRegulationOfOxidoreductaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","oxidoreductase","activity",",","the","catalysis","of","an","oxidation-reduction","(","redox",")","reaction",",","a","reversible","chemical","reaction","in","which","the","oxidation","state","of","an","atom","or","atoms","within","a","molecule","is","altered","."),4171879). assertion_content_comment('tOboGo_NegativeRegulationOfOxygenAndReactiveOxygenSpeciesMetabolicProcess',s("OBSOLETE",".","Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","dioxygen","(","O2",")",",","or","any","of","the","reactive","oxygen","species",",","e.g",".","superoxide","anions","(","O2-",")",",","hydrogen","peroxide","(","H2O2",")",",","and","hydroxyl","radicals","(","-OH",")"),4336383). assertion_content_comment('tOboGo_NegativeRegulationOfOxygenMetabolicProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","oxygen","metabolic","process","."),4143039). assertion_content_comment('tOboGo_NegativeRegulationOfPancreaticACellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","pancreatic","A","cell","differentiation","."),4140953). assertion_content_comment('tOboGo_NegativeRegulationOfPancreaticJuiceSecretion',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","pancreatic","juice","secretion",",","the","regulated","release","of","pancreatic","juice","by","the","exocrine","pancreas","into","the","upper","part","of","the","intestine","."),4149468). assertion_content_comment('tOboGo_NegativeRegulationOfPancreaticStellateCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","pancreatic","stellate","cell","proliferation","."),4140595). assertion_content_comment('tOboGo_NegativeRegulationOfParaxialMesodermalCellFateDetermination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","paraxial","mesoderm","cell","fate","determination","."),4102757). assertion_content_comment('tOboGo_NegativeRegulationOfParaxialMesodermalCellFateSpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","paraxial","mesoderm","cell","fate","specification","."),4102690). assertion_content_comment('tOboGo_NegativeRegulationOfPenicillinCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","leading","to","the","breakdown","of","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4066815). assertion_content_comment('tOboGo_NegativeRegulationOfPenicillinMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4066794). assertion_content_comment('tOboGo_NegativeRegulationOfPenileErection',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","penile","erection",".","Penile","erection","is","the","hardening",",","enlarging","and","rising","of","the","penis","which","often","occurs","in","the","sexually","aroused","male","and","enables","sexual","intercourse",".","Achieved","by","increased","inflow","of","blood","into","the","vessels","of","erectile","tissue",",","and","decreased","outflow","."),4117456). assertion_content_comment('tOboGo_NegativeRegulationOfPeptidaseActivityInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protease","activity",",","the","catalysis","of","the","hydrolysis","of","peptide","bonds","in","a","protein",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4188025). assertion_content_comment('tOboGo_NegativeRegulationOfPeptidaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","peptidase","activity",",","the","hydrolysis","of","peptide","bonds","within","proteins","."),4170375). assertion_content_comment('tOboGo_NegativeRegulationOfPeptideHormoneProcessing',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","peptide","hormone","processing",".","Peptide","hormone","processing","is","the","generation","of","a","mature","peptide","hormone","by","posttranslational","processing","of","a","prohormone","."),4117176). assertion_content_comment('tOboGo_NegativeRegulationOfPeptideHormoneSecretion',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","regulated","release","of","a","peptide","hormone","from","secretory","granules","."),4099203). assertion_content_comment('tOboGo_NegativeRegulationOfPeptideSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","peptide","secretion","."),3997292). assertion_content_comment('tOboGo_NegativeRegulationOfPeptidoglycanRecognitionProteinSignalingPathway',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","peptidoglycan","recognition","protein","signaling","pathway","."),4113668). assertion_content_comment('tOboGo_NegativeRegulationOfPeripheralBCellAnergy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","peripheral","B","cell","anergy","."),3999725). assertion_content_comment('tOboGo_NegativeRegulationOfPeripheralBCellDeletion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","peripheral","B","cell","deletion","."),3999822). assertion_content_comment('tOboGo_NegativeRegulationOfPeripheralTCellToleranceInduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","peripheral","T","cell","tolerance","induction","."),4000486). assertion_content_comment('tOboGo_NegativeRegulationOfPeripheralToleranceInduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","peripheral","tolerance","induction","."),3995302). assertion_content_comment('tOboGo_NegativeRegulationOfPeroxidaseActivity',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","peroxidase","activity","."),4171887). assertion_content_comment('tOboGo_NegativeRegulationOfPeroxisomeProliferatorActivatedReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","peroxisome","proliferator","activated","receptor","signaling","pathway","."),4083380). assertion_content_comment('tOboGo_NegativeRegulationOfPhagocytosisEngulfment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","internalization","of","bacteria",",","immune","complexes","and","other","particulate","matter","or","of","an","apoptotic","cell","by","phagocytosis","."),4108773). assertion_content_comment('tOboGo_NegativeRegulationOfPhagocytosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","phagocytosis","."),4101025). assertion_content_comment('tOboGo_NegativeRegulationOfPhialideDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","phialide","development",",","a","process","that","leads","to","the","formation","of","phialides",".","Phialides","are","specialized","cells","that","bud","from","the","ends","of","metulae","on","the","conidiophore","tip","."),4132411). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphataseActivity',s("Any","process","that","decreases","the","rate","or","frequency","of","phosphatase","activity",".","Phosphatases","catalyze","the","hydrolysis","of","phosphoric","monoesters",",","releasing","inorganic","phosphate","."),4331599). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphateMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","phosphates","."),3988705). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphateTransmembraneTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","phosphate","transmembrane","transport","."),4141315). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphatidylcholineCatabolicProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","phosphatidylcholine","catabolism",".","Phosphatidylcholine","catabolic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphatidylcholines",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","choline","."),4038085). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphatidylinositolBiosyntheticProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidylinositol","."),4030308). assertion_content_comment('tOboGo_NegativeRegulationOfPhospholipaseActivity',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","phospholipase","activity",",","the","hydrolysis","of","a","phospholipid","."),4061646). assertion_content_comment('tOboGo_NegativeRegulationOfPhospholipidBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phospholipids","."),4030297). assertion_content_comment('tOboGo_NegativeRegulationOfPhospholipidTranslocation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","translocation",",","or","flipping",",","of","phospholipid","molecules","from","one","monolayer","of","a","membrane","bilayer","to","the","opposite","monolayer","."),4135404). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphoproteinPhosphataseActivity',s("Any","process","that","stops","or","reduces","the","activity","of","a","phosphoprotein","phosphatase","."),4331603). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphorusMetabolicProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","phosphorus","or","compounds","containing","phosphorus","."),3988701). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphorusUtilization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","phosphorus","utilization","."),4092672). assertion_content_comment('tOboGo_NegativeRegulationOfPhosphorylation',s("Any","process","that","stops",",","prevents","or","decreases","the","rate","of","addition","of","phosphate","groups","to","a","molecule","."),3988713). assertion_content_comment('tOboGo_NegativeRegulationOfPhotomorphogenesis',s("Any","process","that","stops",",","reduces","or","prevents","photomorphogenesis","."),4033035). assertion_content_comment('tOboGo_NegativeRegulationOfPhotoreceptorCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","photoreceptor","cell","differentiation",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4087486). assertion_content_comment('tOboGo_NegativeRegulationOfPhotosynthesisLightReaction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","light-dependent","reaction","of","photosynthesis","."),4031609). assertion_content_comment('tOboGo_NegativeRegulationOfPhytoalexinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","phytoalexin","biosynthesis",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytoalexins","."),4110393). assertion_content_comment('tOboGo_NegativeRegulationOfPhytoalexinMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","phytoalexin","metabolism",",","the","chemical","reactions","and","pathways","involving","phytoalexins","."),4110385). assertion_content_comment('tOboGo_NegativeRegulationOfPigmentCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","pigment","cell","differentiation","."),4087038). assertion_content_comment('tOboGo_NegativeRegulationOfPinocytosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","pinocytosis",".","Pinocytosis","is","the","process","in","which","cells","take","in","liquid","material","from","their","external","environment",";","literally","'","cell","drinking","'","Liquid","is","enclosed","in","vesicles",",","formed","by","invagination","of","the","plasma","membrane",".","These","vesicles","then","move","into","the","cell","and","pass","their","contents","to","endosomes","."),4102946). assertion_content_comment('tOboGo_NegativeRegulationOfPlanarCellPolarityPathwayInvolvedInAxisElongation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","axis","elongation","."),4139054). assertion_content_comment('tOboGo_NegativeRegulationOfPlanarCellPolarityPathwayInvolvedInCardiacMuscleTissueMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","cardiac","muscle","tissue","morphogenesis","."),4137900). assertion_content_comment('tOboGo_NegativeRegulationOfPlanarCellPolarityPathwayInvolvedInCardiacRightAtriumMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","cardiac","right","atrium","morphogenesis","."),4141506). assertion_content_comment('tOboGo_NegativeRegulationOfPlanarCellPolarityPathwayInvolvedInHeartMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","heart","morphogenesis","."),4137897). assertion_content_comment('tOboGo_NegativeRegulationOfPlanarCellPolarityPathwayInvolvedInNeuralTubeClosure',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","neural","tube","closure","."),4141663). assertion_content_comment('tOboGo_NegativeRegulationOfPlanarCellPolarityPathwayInvolvedInOutflowTractMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","outflow","tract","morphogenesis","."),4141485). assertion_content_comment('tOboGo_NegativeRegulationOfPlanarCellPolarityPathwayInvolvedInPericardiumMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","pericardium","morphogenesis","."),4141685). assertion_content_comment('tOboGo_NegativeRegulationOfPlanarCellPolarityPathwayInvolvedInVentricularSeptumMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","ventricular","septum","morphogenesis","."),4137911). assertion_content_comment('tOboGo_NegativeRegulationOfPlasmacytoidDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","plasmacytoid","dendritic","cell","antigen","processing","and","presentation","."),3994709). assertion_content_comment('tOboGo_NegativeRegulationOfPlasmacytoidDendriticCellCytokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","plasmacytoid","dendritic","cell","cytokine","production","."),3997256). assertion_content_comment('tOboGo_NegativeRegulationOfPlasmaLipoproteinParticleOxidation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","lipoprotein","particle","oxidation",",","occurring","in","the","blood","plasma","."),4074936). assertion_content_comment('tOboGo_NegativeRegulationOfPlasmatocyteDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","plasmatocyte","differentiation","."),4087225). assertion_content_comment('tOboGo_NegativeRegulationOfPlasminogenActivation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","plasminogen","activation",".","Plasminogen","activation","is","the","process","in","which","plasminogen","is","processed","to","plasmin","."),4024898). assertion_content_comment('tOboGo_NegativeRegulationOfPlateletActivation',s("Any","process","that","decreases","the","rate","or","frequency","of","platelet","activation",".","Platelet","activation","is","a","series","of","progressive",",","overlapping","events","triggered","by","exposure","of","the","platelets","to","subendothelial","tissue","."),4027279). assertion_content_comment('tOboGo_NegativeRegulationOfPlateletAggregation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","platelet","aggregation",".","Platelet","aggregation","is","the","adhesion","of","one","platelet","to","one","or","more","other","platelets","via","adhesion","molecules","."),4150608). assertion_content_comment('tOboGo_NegativeRegulationOfPodosomeAssembly',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","podosome","assembly","."),4129451). assertion_content_comment('tOboGo_NegativeRegulationOfPolarizedEpithelialCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","polarized","epithelial","cell","differentiation","."),4061803). assertion_content_comment('tOboGo_NegativeRegulationOfPolePlasmOskarMRNALocalization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","process","in","which","oskar","mRNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm","."),4090296). assertion_content_comment('tOboGo_NegativeRegulationOfPositiveChemotaxis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","in","a","concentration","gradient","of","a","specific","chemical","."),4099999). assertion_content_comment('tOboGo_NegativeRegulationOfPositiveChemotaxisToCAMPByChlorinatedAlkylphenone',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","by","the","action","of","a","chlorinated","alkylphenone",".","An","alkylphenone","is","an","aromatic","polyketide","with","methyl","and","chlorine","substitutions","."),4156085). assertion_content_comment('tOboGo_NegativeRegulationOfPositiveChemotaxisToCAMP',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","."),4135498). assertion_content_comment('tOboGo_NegativeRegulationOfPosttranscriptionalGeneSilencing',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","inactivation","of","gene","expression","by","a","posttranscriptional","mechanism","."),4108267). assertion_content_comment('tOboGo_NegativeRegulationOfPotassiumIonTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","potassium","ions","(","K","+",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4093243). assertion_content_comment('tOboGo_NegativeRegulationOfPreblastodermMitoticCellCycle',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","progression","through","the","preblastoderm","mitotic","cell","cycle","."),4092039). assertion_content_comment('tOboGo_NegativeRegulationOfPrimaryMicroRNAProcessing',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","primary","microRNA","processing","."),4143919). assertion_content_comment('tOboGo_NegativeRegulationOfProductionOfMolecularMediatorOfImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","the","production","of","molecular","mediator","of","immune","response","."),3995496). assertion_content_comment('tOboGo_NegativeRegulationOfProgesteroneBiosynthesisInvolvedInLuteolysis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","biosynthesis","of","progesterone","biosynthesis","that","contributes","to","luteolysis","."),4133640). assertion_content_comment('tOboGo_NegativeRegulationOfProgesteroneBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","progesterone","biosynthetic","process","."),4133632). assertion_content_comment('tOboGo_NegativeRegulationOfProgrammedCellDeath',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","programmed","cell","death",",","cell","death","resulting","from","activation","of","endogenous","cellular","processes","."),3999553). assertion_content_comment('tOboGo_NegativeRegulationOfProlineMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","proline","metabolic","process","."),4140738). assertion_content_comment('tOboGo_NegativeRegulationOfProstaglandinBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","prostaglandin","."),4058518). assertion_content_comment('tOboGo_NegativeRegulationOfProstaglandinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","prostaglandin","from","a","cell","or","group","of","cells","."),4056320). assertion_content_comment('tOboGo_NegativeRegulationOfProstaticBudFormation',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","prostatic","bud","formation",",","the","morphogenetic","process","in","which","a","region","of","the","fetal","urogenital","sinus","epithelium","is","specified","to","become","the","prostate",",","resulting","in","prostate","bud","outgrowth","."),4112293). assertion_content_comment('tOboGo_NegativeRegulationOfProstheticGroupMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","prosthetic","group","."),4119605). assertion_content_comment('tOboGo_NegativeRegulationOfProteinActivationCascade',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","protein","activation","cascade","."),3986363). assertion_content_comment('tOboGo_NegativeRegulationOfProteinAutophosphorylation',s("Any","process","that","stops",",","prevents","or","decreases","the","rate","of","the","phosphorylation","by","a","protein","of","one","or","more","of","its","own","residues","."),4057340). assertion_content_comment('tOboGo_NegativeRegulationOfProteinBinding',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","binding","."),4154951). assertion_content_comment('tOboGo_NegativeRegulationOfProteinCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","by","the","destruction","of","the","native",",","active","configuration",",","with","or","without","the","hydrolysis","of","peptide","bonds","."),3995756). assertion_content_comment('tOboGo_NegativeRegulationOfProteinComplexAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","complex","assembly","."),3988901). assertion_content_comment('tOboGo_NegativeRegulationOfProteinComplexDisassembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","complex","disassembly",",","the","disaggregation","of","a","protein","complex","into","its","constituent","components","."),4013305). assertion_content_comment('tOboGo_NegativeRegulationOfProteinDephosphorylation',s("Any","process","the","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","removal","of","phosphate","groups","from","a","protein","."),4071422). assertion_content_comment('tOboGo_NegativeRegulationOfProteinDesumoylation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","protein","desumoylation",".","Protein","desumoylation","is","the","process","in","which","a","SUMO","protein","(","small","ubiquitin-related","modifier",")","is","cleaved","from","its","target","protein","."),4115531). assertion_content_comment('tOboGo_NegativeRegulationOfProteinDeubiquitination',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","protein","deubiquitination",".","Protein","deubiquitination","is","the","removal","of","one","or","more","ubiquitin","groups","from","a","protein","."),4150287). assertion_content_comment('tOboGo_NegativeRegulationOfProteinExitFromEndoplasmicReticulum',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","proteins","from","the","endoplasmic","reticulum","."),4132304). assertion_content_comment('tOboGo_NegativeRegulationOfProteinExportFromNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","proteins","from","the","nucleus","into","the","cytoplasm","."),4099613). assertion_content_comment('tOboGo_NegativeRegulationOfProteinGeranylgeranylation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","protein","geranylgeranylation","."),4145388). assertion_content_comment('tOboGo_NegativeRegulationOfProteinGlutathionylation',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","protein","glutathionylation",".","Protein","glutathionylation","is","the","protein","modification","process","in","which","a","glutathione","molecule","is","added","to","a","protein","amino","acid","through","a","disulfide","linkage","."),4024495). assertion_content_comment('tOboGo_NegativeRegulationOfProteinGlycosylationInGolgi',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","addition","of","a","sugar","unit","to","a","protein","amino","acid","in","any","compartment","of","the","Golgi","apparatus","."),4152138). assertion_content_comment('tOboGo_NegativeRegulationOfProteinGlycosylation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","glycosylation","of","one","or","more","amino","acid","residues","within","a","protein",".","Protein","glycosylation","is","the","addition","of","a","sugar","unit","to","a","protein","amino","acid",",","e.g",".","the","addition","of","glycan","chains","to","proteins","."),4109180). assertion_content_comment('tOboGo_NegativeRegulationOfProteinHistidineKinaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","histidine","kinase","activity","."),4329004). assertion_content_comment('tOboGo_NegativeRegulationOfProteinHomodimerizationActivity',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","protein","homodimerization",",","interacting","selectively","with","an","identical","protein","to","form","a","homodimer","."),4154968). assertion_content_comment('tOboGo_NegativeRegulationOfProteinHomooligomerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","homooligomerization","."),4055917). assertion_content_comment('tOboGo_NegativeRegulationOfProteinImportIntoNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","movement","of","proteins","from","the","cytoplasm","into","the","nucleus","."),4016396). assertion_content_comment('tOboGo_NegativeRegulationOfProteinImportIntoNucleusTranslocation',s("Any","process","that","stops",",","prevents","or","reduces","the","vectorial","transfer","of","a","protein","from","the","cytoplasm","into","the","nucleus",",","across","the","nuclear","membrane","."),4065688). assertion_content_comment('tOboGo_NegativeRegulationOfProteinKinaseActivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","kinase","activity","."),3972881). assertion_content_comment('tOboGo_NegativeRegulationOfProteinKinaseBSignalingCascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","protein","kinase","B","signaling","cascade",",","a","series","of","reactions","mediated","by","the","intracellular","serine/threonine","kinase","protein","kinase","B","."),4120115). assertion_content_comment('tOboGo_NegativeRegulationOfProteinKinaseCSignalingCascade',s("Any","process","that","decreases","the","frequency",",","rate",",","or","extent","of","a","series","of","reactions",",","mediated","by","the","intracellular","serine/threonine","kinase","protein","kinase","C",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4149980). assertion_content_comment('tOboGo_NegativeRegulationOfProteinLocalizationAtCellSurface',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","localization","at","cell","surface","."),4139389). assertion_content_comment('tOboGo_NegativeRegulationOfProteinMaturationByPeptideBondCleavage',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","protein","maturation","by","peptide","bond","cleavage","."),3986349). assertion_content_comment('tOboGo_NegativeRegulationOfProteinMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","involving","a","protein","."),3975717). assertion_content_comment('tOboGo_NegativeRegulationOfProteinModificationProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","covalent","alteration","of","one","or","more","amino","acid","residues","within","a","protein","."),3975733). assertion_content_comment('tOboGo_NegativeRegulationOfProteinNeddylation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","protein","neddylation","."),4142005). assertion_content_comment('tOboGo_NegativeRegulationOfProteinOligomerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","protein","oligomerization","."),4055492). assertion_content_comment('tOboGo_NegativeRegulationOfProteinPhosphataseType2AActivity',s("Any","process","that","stops","or","reduces","the","activity","of","the","enzyme","protein","phosphatase","type","2A","."),4360887). assertion_content_comment('tOboGo_NegativeRegulationOfProteinPhosphataseType2BActivity',s("Any","process","that","stops","or","reduces","the","activity","of","the","enzyme","protein","phosphatase","type","2B","."),4331618). assertion_content_comment('tOboGo_NegativeRegulationOfProteinPhosphorylation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","of","addition","of","phosphate","groups","to","amino","acids","within","a","protein","."),3988720). assertion_content_comment('tOboGo_NegativeRegulationOfProteinPolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","process","of","creating","protein","polymers","."),4051037). assertion_content_comment('tOboGo_NegativeRegulationOfProteinRefolding',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","protein","refolding",".","Protein","refolding","is","the","process","carried","out","by","a","cell","that","restores","the","biological","activity","of","an","unfolded","or","misfolded","protein",",","using","helper","proteins","such","as","chaperones","."),4135202). assertion_content_comment('tOboGo_NegativeRegulationOfProteinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","controlled","release","of","a","protein","from","a","cell","or","group","of","cells","."),3997106). assertion_content_comment('tOboGo_NegativeRegulationOfProteinSerineThreonineKinaseActivity',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","protein","serine/threonine","kinase","activity","."),3972888). assertion_content_comment('tOboGo_NegativeRegulationOfProteinSumoylation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","addition","of","SUMO","groups","to","a","protein","."),4066558). assertion_content_comment('tOboGo_NegativeRegulationOfProteinTargetingToMembrane',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","process","of","directing","proteins","towards","a","membrane",",","usually","using","signals","contained","within","the","protein","."),4150749). assertion_content_comment('tOboGo_NegativeRegulationOfProteinTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","protein","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3997099). assertion_content_comment('tOboGo_NegativeRegulationOfProteinTyrosineKinaseActivity',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","protein","tyrosine","kinase","activity","."),4155934). assertion_content_comment('tOboGo_NegativeRegulationOfProteinUbiquitination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","addition","of","ubiquitin","groups","to","a","protein","."),4058620). assertion_content_comment('tOboGo_NegativeRegulationOfProteolysisAssociatedWithAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","proteolysis","associated","with","antigen","processing","and","presentation","."),3995767). assertion_content_comment('tOboGo_NegativeRegulationOfProteolysis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","."),3986341). assertion_content_comment('tOboGo_NegativeRegulationOfPseudohyphalGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","pseudohyphal","growth","."),4140820). assertion_content_comment('tOboGo_NegativeRegulationOfPseudopodiumAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","assembly","of","pseudopodia","."),4059461). assertion_content_comment('tOboGo_NegativeRegulationOfPteridineMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","pteridine","."),4090380). assertion_content_comment('tOboGo_NegativeRegulationOfPurineBaseMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","purine","bases","."),4092285). assertion_content_comment('tOboGo_NegativeRegulationOfPurineNucleosideTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","purine","nucleoside","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053873). assertion_content_comment('tOboGo_NegativeRegulationOfPurineNucleotideCatabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","nucleotides","."),4050488). assertion_content_comment('tOboGo_NegativeRegulationOfPyrimidineBaseMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","pyrimidine","bases","."),4092185). assertion_content_comment('tOboGo_NegativeRegulationOfR7CellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","R7cell","differentiation","."),4087498). assertion_content_comment('tOboGo_NegativeRegulationOfR8CellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","R8","cell","differentiation","."),4091615). assertion_content_comment('tOboGo_NegativeRegulationOfR8CellSpacingInCompoundEye',s("Any","process","that","stops","or","prevents","the","correct","R8","cell","spacing","pattern","in","a","compound","eye","."),4299468). assertion_content_comment('tOboGo_NegativeRegulationOfRacProteinSignalTransduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Rac","protein","signal","transduction","."),4072543). assertion_content_comment('tOboGo_NegativeRegulationOfRanProteinSignalTransduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Ran","protein","signal","transduction","."),4056952). assertion_content_comment('tOboGo_NegativeRegulationOfRasGTPaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","activity","of","a","GTPase","of","the","Ras","superfamily","."),4359507). assertion_content_comment('tOboGo_NegativeRegulationOfRasProteinSignalTransduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Ras","protein","signal","transduction","."),4056945). assertion_content_comment('tOboGo_NegativeRegulationOfReactiveOxygenSpeciesMetabolicProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","reactive","oxygen","species","metabolic","process","."),4024312). assertion_content_comment('tOboGo_NegativeRegulationOfReceptorActivity',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","receptor","activity","."),4161155). assertion_content_comment('tOboGo_NegativeRegulationOfReceptorBiosyntheticProcess',s("Any","process","that","decreases","the","frequency","or","rate","of","receptor","biosynthesis",".","Receptor","biosynthesis","is","the","collection","of","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","receptor","molecule",",","a","macromolecule","that","undergoes","combination","with","a","hormone",",","neurotransmitter",",","drug","or","intracellular","messenger","to","initiate","a","change","in","cell","function","."),4037209). assertion_content_comment('tOboGo_NegativeRegulationOfReceptorCatabolicProcess',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","receptor","catabolic","process","."),4070504). assertion_content_comment('tOboGo_NegativeRegulationOfReceptorInternalization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","receptor","internalization","."),3989918). assertion_content_comment('tOboGo_NegativeRegulationOfReceptorRecycling',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","receptor","recycling","."),3989468). assertion_content_comment('tOboGo_NegativeRegulationOfReciprocalMeioticRecombination',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","recombination","during","meiosis",".","Reciprocal","meiotic","recombination","is","the","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","."),4086486). assertion_content_comment('tOboGo_NegativeRegulationOfRecombinationWithinRDNARepeats',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","genetic","recombination","within","the","DNA","of","the","genes","coding","for","ribosomal","RNA","."),4345491). assertion_content_comment('tOboGo_NegativeRegulationOfRegulationOfExcitatoryPostsynapticMembranePotential',s("OBSOLETE",".","Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","regulation","of","excitatory","postsynaptic","membrane","potential","."),4169095). assertion_content_comment('tOboGo_NegativeRegulationOfRegulationOfTranscriptionFromRNAPolymeraseIIPromoterByNuclearHormoneReceptor',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","regulation","of","transcription","from","RNA","polymerase","II","promoter","by","nuclear","hormone","receptor","."),4170329). assertion_content_comment('tOboGo_NegativeRegulationOfRegulatoryTCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","differentiation","of","regulatory","T","cells","."),4069725). assertion_content_comment('tOboGo_NegativeRegulationOfReleaseOfCytochromeCFromMitochondria',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","release","of","cytochrome","c","from","mitochondria",",","the","process","in","which","cytochrome","c","is","enabled","to","move","from","the","mitochondrial","intermembrane","space","into","the","cytosol",",","which","is","an","early","step","in","apoptosis","and","leads","to","caspase","activation","."),4149511). assertion_content_comment('tOboGo_NegativeRegulationOfReleaseOfSequesteredCalciumIonIntoCytosol',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","release","into","the","cytosolic","compartment","of","calcium","ions","sequestered","in","the","endoplasmic","reticulum","or","mitochondria","."),4119961). assertion_content_comment('tOboGo_NegativeRegulationOfRenalAlbuminAbsorption',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","renal","albumin","absorption","."),4145173). assertion_content_comment('tOboGo_NegativeRegulationOfRenalOutputByAngiotensin',s("The","process","in","which","angiotensin","directly","decreases","the","rate","of","natriuresis","and","diuresis","in","the","kidney","."),4004041). assertion_content_comment('tOboGo_NegativeRegulationOfRenalSodiumExcretionByAngiotensin',s("The","process","in","which","angiotensin","decreases","the","amount","of","sodium","that","is","excreted","in","urine","over","a","unit","of","time","."),4370480). assertion_content_comment('tOboGo_NegativeRegulationOfRenalSodiumExcretion',s("Any","process","that","decreases","the","amount","of","sodium","excreted","in","urine","over","a","unit","of","time","."),4081103). assertion_content_comment('tOboGo_NegativeRegulationOfReproductiveProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","reproductive","process","."),4021363). assertion_content_comment('tOboGo_NegativeRegulationOfRespiratoryBurstInvolvedInInflammatoryResponse',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","a","phase","of","elevated","metabolic","activity",",","during","which","oxygen","consumption","increases","made","as","a","defense","response",";","this","leads","to","the","production",",","by","an","NADH","dependent","system",",","of","hydrogen","peroxide","(","H2O2",")",",","superoxide","anions","and","hydroxyl","radicals","."),4115990). assertion_content_comment('tOboGo_NegativeRegulationOfRespiratoryBurst',s("Any","process","that","decreases","the","rate","frequency","or","extent","of","a","phase","of","elevated","metabolic","activity",",","during","which","oxygen","consumption","increases",";","this","leads","to","the","production",",","by","an","NADH","dependent","system",",","of","hydrogen","peroxide","(","H2O2",")",",","superoxide","anions","and","hydroxyl","radicals","."),4115986). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToBioticStimulus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","response","to","biotic","stimulus","."),4000003). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToCytokineStimulus',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","a","response","to","cytokine","stimulus","."),3987904). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToExternalStimulus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","response","to","an","external","stimulus","."),3983785). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToExtracellularStimulus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","response","to","an","extracellular","stimulus","."),4030022). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToFood',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","response","to","a","food","stimulus","."),4057125). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToNutrientLevels',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","response","to","nutrient","levels","."),4030040). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToStimulus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","response","to","a","stimulus",".","Response","to","stimulus","is","a","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","stimulus","."),3983762). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToTumorCell',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","response","to","tumor","cell","."),4000022). assertion_content_comment('tOboGo_NegativeRegulationOfResponseToWaterDeprivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","response","to","water","deprivation",".","Response","to","water","deprivation","is","a","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","water","deprivation","stimulus",",","prolonged","deprivation","of","water","."),4147870). assertion_content_comment('tOboGo_NegativeRegulationOfRestrictionEndodeoxyribonucleaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","a","restriction","endodeoxyribonuclease","activity",",","the","catalysis","of","endonucleolytic","cleavage","of","DNA","in","a","site-specific","manner",",","resulting","in","double-strand","breaks","."),4330564). assertion_content_comment('tOboGo_NegativeRegulationOfRetinalCellProgrammedCellDeath',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","programmed","cell","death","that","occurs","in","the","retina","."),4099152). assertion_content_comment('tOboGo_NegativeRegulationOfRetinalConeCellFateCommitment',s("Any","process","that","increases","the","process","in","which","a","cell","becomes","committed","to","a","retinal","cone","cell","fate",".","Retinal","cone","cell","fate","commitment","is","the","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","retinal","cone","cell","."),4115421). assertion_content_comment('tOboGo_NegativeRegulationOfRetinalConeCellFateSpecification',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","specifying","into","a","retinal","cone","cell","."),4033617). assertion_content_comment('tOboGo_NegativeRegulationOfRetinalGanglionCellAxonGuidance',s("Any","process","that","decreases","the","frequency",",","rate",",","or","extent","of","retinal","ganglion","cell","axon","guidance",",","the","process","in","which","the","migration","of","an","axon","growth","cone","of","a","retinal","ganglion","cell","(","RGC",")","is","directed","to","its","target","in","the","brain","in","response","to","a","combination","of","attractive","and","repulsive","cues","."),4151926). assertion_content_comment('tOboGo_NegativeRegulationOfRetinoicAcidReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","retinoic","acid","receptor","signaling","pathway","activity","."),4102220). assertion_content_comment('tOboGo_NegativeRegulationOfRetroviralGenomeReplication',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","retroviral","genome","replication","."),4090363). assertion_content_comment('tOboGo_NegativeRegulationOfRhodopsinGeneExpression',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","rhodopsin","gene","expression","."),4298320). assertion_content_comment('tOboGo_NegativeRegulationOfRhoGTPaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","activity","of","a","GTPase","of","the","Rho","family","."),4359513). assertion_content_comment('tOboGo_NegativeRegulationOfRhoProteinSignalTransduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Rho","protein","signal","transduction","."),4072574). assertion_content_comment('tOboGo_NegativeRegulationOfRibonucleaseActivity',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","ribonuclease","activity",",","catalysis","of","the","hydrolysis","of","phosphodiester","bonds","in","chains","of","RNA","."),4161256). assertion_content_comment('tOboGo_NegativeRegulationOfRibonucleoproteinComplexLocalization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ribonucleoprotein","complex","localization","."),4141022). assertion_content_comment('tOboGo_NegativeRegulationOfRibosomalLargeSubunitExportFromNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ribosomal","large","subunit","export","from","nucleus","."),4141260). assertion_content_comment('tOboGo_NegativeRegulationOfRibosomalProteinGeneTranscriptionFromRNAPolymeraseIIPromoterInResponseToChemicalStimulus',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","synthesis","of","RNA","from","ribosomal","protein","genes","by","RNA","polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter",",","as","a","result","of","a","chemical","stimulus","."),4336470). assertion_content_comment('tOboGo_NegativeRegulationOfRibosomalProteinGeneTranscriptionFromRNAPolymeraseIIPromoterInResponseToNutrientLevels',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","synthesis","of","RNA","from","ribosomal","protein","genes","by","RNA","polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter",",","as","a","result","of","a","stimulus","reflecting","the","presence",",","absence",",","or","concentration","of","nutrients","."),4336499). assertion_content_comment('tOboGo_NegativeRegulationOfRibosomalProteinGeneTranscriptionFromRNAPolymeraseIIPromoterInResponseToStress',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","synthesis","of","RNA","from","ribosomal","protein","genes","by","RNA","polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter",",","as","a","result","of","a","disturbance","in","organismal","or","cellular","homeostasis","."),4336529). assertion_content_comment('tOboGo_NegativeRegulationOfRibosomalProteinGeneTranscriptionFromRNAPolymeraseIIPromoter',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","synthesis","of","RNA","from","ribosomal","protein","genes","by","RNA","polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter","."),4336460). assertion_content_comment('tOboGo_NegativeRegulationOfRibosomalSmallSubunitExportFromNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ribosomal","small","subunit","export","from","nucleus","."),4141072). assertion_content_comment('tOboGo_NegativeRegulationOfRibosomalSubunitExportFromNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ribosomal","subunit","export","from","nucleus","."),4141047). assertion_content_comment('tOboGo_NegativeRegulationOfRibosomeBiogenesis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","ribosome","biogenesis",".","Ribosome","biogenesis","is","the","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","ribosome","subunits","."),4150191). assertion_content_comment('tOboGo_NegativeRegulationOfRNAExportFromNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","RNA","from","the","nucleus","into","the","cytoplasm","."),4099527). assertion_content_comment('tOboGo_NegativeRegulationOfRNAImportIntoNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","movement","of","RNA","from","the","cytoplasm","into","the","nucleus","."),4099574). assertion_content_comment('tOboGo_NegativeRegulationOfRNAMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","RNA","."),3971563). assertion_content_comment('tOboGo_NegativeRegulationOfRNAPolymeraseIITranscriptionalPreinitiationComplexAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","RNA","polymerase","II","transcriptional","preinitiation","complex","assembly","."),4040858). assertion_content_comment('tOboGo_NegativeRegulationOfRNASplicing',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","RNA","splicing","."),4065904). assertion_content_comment('tOboGo_NegativeRegulationOfRoundaboutSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","Roundabout","signaling","pathway","."),4082200). assertion_content_comment('tOboGo_NegativeRegulationOfRRNAProcessing',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","rRNA","processing","."),4140640). assertion_content_comment('tOboGo_NegativeRegulationOfSalivaryGlandBoundarySpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","salivary","gland","determination","."),4091648). assertion_content_comment('tOboGo_NegativeRegulationOfSarcomereOrganization',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","myofibril","assembly","by","organization","of","muscle","actomyosin","into","sarcomeres",".","The","sarcomere","is","the","repeating","unit","of","a","myofibril","in","a","muscle","cell",",","composed","of","an","array","of","overlapping","thick","and","thin","filaments","between","two","adjacent","Z","discs","."),4115797). assertion_content_comment('tOboGo_NegativeRegulationOfSchwannCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Schwann","cell","differentiation","."),4039166). assertion_content_comment('tOboGo_NegativeRegulationOfSchwannCellProliferation',s("Any","process","that","decreases","the","frequency","or","extent","of","the","multiplication","or","reproduction","of","Schwann","cells",",","resulting","in","the","expansion","of","their","population",".","Schwann","cells","are","a","type","of","glial","cell","in","the","peripheral","nervous","system","."),4028650). assertion_content_comment('tOboGo_NegativeRegulationOfSecondaryGrowth',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","secondary","growth","."),4143758). assertion_content_comment('tOboGo_NegativeRegulationOfSecretionOfLysosomalEnzymes',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","secretion","of","lysosomal","enzymes",",","the","controlled","release","of","lysosomal","enzymes","by","a","cell","or","group","of","cells","."),4150996). assertion_content_comment('tOboGo_NegativeRegulationOfSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","controlled","release","of","a","substance","from","a","cell","or","group","of","cells","."),3997083). assertion_content_comment('tOboGo_NegativeRegulationOfSeedGermination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","seed","germination","."),4031507). assertion_content_comment('tOboGo_NegativeRegulationOfSeptationInitiationSignalingCascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","septation","initiation","signaling","."),4060948). assertion_content_comment('tOboGo_NegativeRegulationOfSequesteringOfCalciumIon',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","binding","or","confining","calcium","ions","such","that","they","are","separated","from","other","components","of","a","biological","system","."),4021071). assertion_content_comment('tOboGo_NegativeRegulationOfSequesteringOfTriglyceride',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","sequestering","of","triglyceride",".","Triglyceride","sequestration","is","the","process","of","binding","or","confining","any","triester","of","glycerol","such","that","it","is","separated","from","other","components","of","a","biological","system","."),4037601). assertion_content_comment('tOboGo_NegativeRegulationOfSequesteringOfZincIon',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","sequestering","of","zinc","ion",".","Sequestering","of","zinc","ion","is","the","process","of","binding","or","confining","zinc","ions","such","that","they","are","separated","from","other","components","of","a","biological","system","."),4135170). assertion_content_comment('tOboGo_NegativeRegulationOfSerotoninSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","regulated","release","of","serotonin","."),4039428). assertion_content_comment('tOboGo_NegativeRegulationOfSerotoninUptake',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","serotonin","into","a","cell","."),4121668). assertion_content_comment('tOboGo_NegativeRegulationOfSevenlessSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","sevenless","signaling","pathway","."),4090447). assertion_content_comment('tOboGo_NegativeRegulationOfSexualSporulationResultingInFormationOfACellularSpore',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","formation","of","cellular","spores","derived","from","the","products","of","meiosis","."),4096540). assertion_content_comment('tOboGo_NegativeRegulationOfSignaling',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","signaling","process","."),3987880). assertion_content_comment('tOboGo_NegativeRegulationOfSignalTransductionInResponseToHost',s("Any","process","in","which","the","symbiont","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","its","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152345). assertion_content_comment('tOboGo_NegativeRegulationOfSignalTransductionInvolvedInConjugationWithCellularFusion',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","series","of","molecular","signals","that","bring","about","the","relay",",","amplification","or","dampening","of","a","signal","generated","in","response","to","a","cue",",","such","as","starvation","or","pheromone","exposure",",","in","organisms","that","undergo","conjugation","with","cellular","fusion","."),4115328). assertion_content_comment('tOboGo_NegativeRegulationOfSignalTransduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signal","transduction","."),3987886). assertion_content_comment('tOboGo_NegativeRegulationOfSisterChromatidCohesion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sister","chromatid","cohesion","."),4076075). assertion_content_comment('tOboGo_NegativeRegulationOfSisterChromatidSegregation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sister","chromatid","segregation","."),4064993). assertion_content_comment('tOboGo_NegativeRegulationOfSiteSelectionInvolvedInCellCycleCytokinesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","site","selection","involved","in","cell","cycle","cytokinesis","."),4138506). assertion_content_comment('tOboGo_NegativeRegulationOfSkeletalMuscleCellProliferation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","skeletal","muscle","cell","proliferation","."),4038685). assertion_content_comment('tOboGo_NegativeRegulationOfSkeletalMuscleContractionByRegulationOfReleaseOfSequesteredCalciumIon',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","skeletal","muscle","contraction","via","the","regulation","of","the","release","of","sequestered","calcium","ion","by","sarcoplasmic","reticulum","into","cytosol",".","The","sarcoplasmic","reticulum","is","the","endoplasmic","reticulum","of","striated","muscle",",","specialised","for","the","sequestration","of","calcium","ions","that","are","released","upon","receipt","of","a","signal","relayed","by","the","T","tubules","from","the","neuromuscular","junction","."),4320791). assertion_content_comment('tOboGo_NegativeRegulationOfSkeletalMuscleFiberDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","skeletal","muscle","fiber","development",".","Muscle","fibers","are","formed","by","the","maturation","of","myotubes",".","They","can","be","classed","as","slow",",","intermediate/fast","or","fast","."),4104797). assertion_content_comment('tOboGo_NegativeRegulationOfSkeletalMuscleTissueDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","skeletal","muscle","tissue","development","."),4039847). assertion_content_comment('tOboGo_NegativeRegulationOfSkeletalMuscleTissueGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","skeletal","muscle","growth","."),4106616). assertion_content_comment('tOboGo_NegativeRegulationOfSkeletalMuscleTissueRegeneration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","skeletal","muscle","regeneration","."),4095923). assertion_content_comment('tOboGo_NegativeRegulationOfSMADProteinComplexAssembly',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","SMAD","protein","complex","assembly",".","SMAD","protein","complex","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","protein","complex","that","contains","SMAD","proteins","."),4035944). assertion_content_comment('tOboGo_NegativeRegulationOfSMADProteinImportIntoNucleus',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","SMAD","protein","import","into","the","nucleus",",","i.e",".","the","directed","movement","of","a","SMAD","proteins","from","the","cytoplasm","into","the","nucleus",".","Pathway-restricted","SMAD","proteins","and","common-partner","SMAD","proteins","are","involved","in","the","transforming","growth","factor","beta","receptor","signaling","pathways","."),4117319). assertion_content_comment('tOboGo_NegativeRegulationOfSmallGTPaseMediatedSignalTransduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","small","GTPase","mediated","signal","transduction","."),4056937). assertion_content_comment('tOboGo_NegativeRegulationOfSmoothenedSignalingPathwayInvolvedInVentralSpinalCordPatterning',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","smoothened","signaling","that","is","involved","in","the","patterns","of","cell","differentiation","in","the","ventral","spinal","cord","."),4048429). assertion_content_comment('tOboGo_NegativeRegulationOfSmoothenedSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","smoothened","signaling","."),4048400). assertion_content_comment('tOboGo_NegativeRegulationOfSmoothMuscleCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","smooth","muscle","cell","apoptosis","."),4074592). assertion_content_comment('tOboGo_NegativeRegulationOfSmoothMuscleCellChemotaxis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","smooth","muscle","cell","chemotaxis","."),4129194). assertion_content_comment('tOboGo_NegativeRegulationOfSmoothMuscleCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","smooth","muscle","cell","differentiation","."),4119772). assertion_content_comment('tOboGo_NegativeRegulationOfSmoothMuscleCellMigration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","smooth","muscle","cell","migration","."),4038810). assertion_content_comment('tOboGo_NegativeRegulationOfSmoothMuscleCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","smooth","muscle","cell","proliferation","."),4106715). assertion_content_comment('tOboGo_NegativeRegulationOfSmoothMuscleContraction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","smooth","muscle","contraction","."),4092218). assertion_content_comment('tOboGo_NegativeRegulationOfSNAREComplexAssembly',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","assembly","of","the","SNARE","complex",".","The","SNARE","complex","is","a","protein","complex","involved","in","membrane","fusion",";","a","stable","ternary","complex","consisting","of","a","four-helix","bundle",",","usually","formed","from","one","R-SNARE","and","three","Q-SNAREs","with","an","ionic","layer","sandwiched","between","hydrophobic","layers","."),4083998). assertion_content_comment('tOboGo_NegativeRegulationOfSNAREComplexDisassembly',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","disassembly","of","the","SNARE","complex",".","The","SNARE","complex","is","a","protein","complex","involved","in","membrane","fusion",";","a","stable","ternary","complex","consisting","of","a","four-helix","bundle",",","usually","formed","from","one","R-SNARE","and","three","Q-SNAREs","with","an","ionic","layer","sandwiched","between","hydrophobic","layers","."),4083954). assertion_content_comment('tOboGo_NegativeRegulationOfSodium_HydrogenAntiporterActivity',s("Any","process","that","stops","or","reduces","the","activity","of","a","sodium",":","hydrogen","antiporter",",","which","catalyzes","the","reaction",":","Na","+","(","out",")","+","H","+","(","in",")","=","Na","+","(","in",")","+","H","+","(","out",")"),4335025). assertion_content_comment('tOboGo_NegativeRegulationOfSodiumIonTransport',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","sodium","ions","(","Na","+",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4025082). assertion_content_comment('tOboGo_NegativeRegulationOfSomatostatinSecretion',s("Any","process","that","decreases","the","rate",",","frequency",",","extent","of","the","regulated","release","of","somatostatin","from","secretory","granules","in","the","D","cells","of","the","pancreas","."),4151754). assertion_content_comment('tOboGo_NegativeRegulationOfSomitomericTrunkMuscleDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","somitomeric","trunk","muscle","development",".","The","somitomeric","trunk","muscle","is","derived","from","somitomeric","mesoderm",".","The","muscle","begins","its","development","with","the","differentiation","of","the","muscle","cells","and","ends","with","the","mature","muscle","."),4039854). assertion_content_comment('tOboGo_NegativeRegulationOfSorocarpStalkCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sorocarp","stalk","cell","differentiation",".","An","example","of","this","process","is","found","in","Dictyostelium","discoideum","."),4059683). assertion_content_comment('tOboGo_NegativeRegulationOfSpermatidNuclearDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","spermatid","nuclear","differentiation","."),4091824). assertion_content_comment('tOboGo_NegativeRegulationOfSPhaseOfMitoticCellCycle',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","S","phase","of","mitotic","cell","cycle","activity","."),4091002). assertion_content_comment('tOboGo_NegativeRegulationOfSphingolipidBiosynthesisInvolvedInCellularSphingolipidHomeostasis',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","sphingolipid","biosynthesis","that","contributes","to","the","maintenance","of","an","internal","equilibrium","of","sphingolipids","at","the","level","of","the","cell","."),4154784). assertion_content_comment('tOboGo_NegativeRegulationOfSphingolipidBiosyntheticProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","sphingolipid","biosynthesis",".","Sphingolipid","biosynthesis","is","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","sphingolipids",",","any","of","a","class","of","lipids","containing","the","long-chain","amine","diol","sphingosine","or","a","closely","related","base","(","a","sphingoid",")"),4098457). assertion_content_comment('tOboGo_NegativeRegulationOfSpindleAstralMicrotubuleDepolymerization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","depolymerization","of","astral","microtubules","."),4064067). assertion_content_comment('tOboGo_NegativeRegulationOfSpindleCheckpoint',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","spindle","checkpoint",",","a","cell","cycle","checkpoint","that","delays","the","metaphase/anaphase","transition","until","the","spindle","is","correctly","assembled","and","oriented",",","and","chromosomes","are","attached","to","the","spindle","."),4151617). assertion_content_comment('tOboGo_NegativeRegulationOfSpindlePoleBodySeparation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","process","involving","the","release","of","duplicated","spindle","pole","bodies","(","SPBs",")","and","their","migration","away","from","each","other","within","the","nuclear","membrane","."),4026774). assertion_content_comment('tOboGo_NegativeRegulationOfSporangiosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sporangiospore","formation",",","a","process","in","which","sporangiospores",",","a","type","of","asexual","spore","found","in","fungi",",","are","formed",".","Sporangiospores","are","formed","within","sac-like","structure",",","the","sporangium",",","following","the","division","of","the","cytoplasm","."),4148248). assertion_content_comment('tOboGo_NegativeRegulationOfSporangiumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sporangium","development",",","a","process","that","leads","to","the","formation","of","sporangium",",","a","single-celled","or","many-celled","structure","in","which","spores","are","produced",",","as","in","fungi",",","algae",",","mosses",",","and","ferns",",","gymnosperms",",","angiosperms","."),4146419). assertion_content_comment('tOboGo_NegativeRegulationOfSporangiumGerminationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sporangium","germination","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146422). assertion_content_comment('tOboGo_NegativeRegulationOfSporeEncystmentOnHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","spore","encystment","on","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146209). assertion_content_comment('tOboGo_NegativeRegulationOfSporeGerminationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","spore","germination","on","or","near","host",",","which","is","the","physiological",",","developmental","and","morphological","changes","that","occur","in","a","symbiont","spore","following","release","from","dormancy","up","to","the","earliest","signs","of","growth","occurring","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146508). assertion_content_comment('tOboGo_NegativeRegulationOfSporeMovementOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","spore","movement","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146476). assertion_content_comment('tOboGo_NegativeRegulationOfSporulationResultingInFormationOfACellularSpore',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sporulation","."),4081020). assertion_content_comment('tOboGo_NegativeRegulationOfSporulation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sporulation",",","the","process","whose","specific","outcome","is","the","progression","of","a","spore","over","time",",","from","its","initiation","to","the","mature","structure","."),4081016). assertion_content_comment('tOboGo_NegativeRegulationOfSproutingOfInjuredAxon',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sprouting","of","an","injured","axon","."),4106931). assertion_content_comment('tOboGo_NegativeRegulationOfSTATProteinImportIntoNucleus',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","STAT","protein","import","into","nucleus","."),4142918). assertion_content_comment('tOboGo_NegativeRegulationOfSteroidBiosyntheticProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","steroids",",","compounds","with","a","1",",","2",",","cyclopentanoperhydrophenanthrene","nucleus","."),4029351). assertion_content_comment('tOboGo_NegativeRegulationOfSteroidHormoneBiosyntheticProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","steroid","hormones",",","compounds","with","a","1",",","2",",","cyclopentanoperhydrophenanthrene","nucleus","that","act","as","hormones","."),4029387). assertion_content_comment('tOboGo_NegativeRegulationOfSteroidHormoneReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","activity","of","any","steroid","hormone","receptor","signaling","pathway","."),4065613). assertion_content_comment('tOboGo_NegativeRegulationOfSteroidMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","steroids","."),4029319). assertion_content_comment('tOboGo_NegativeRegulationOfSterolTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","sterols","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4035323). assertion_content_comment('tOboGo_NegativeRegulationOfStomachNeuroendocrineCellDifferentiation',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","the","differentiation","of","a","neuroendocrine","cell","in","the","stomach","."),4135540). assertion_content_comment('tOboGo_NegativeRegulationOfStomatalComplexDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","stomatal","complex","development","."),4138041). assertion_content_comment('tOboGo_NegativeRegulationOfStrandInvasion',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","strand","invasion",".","Strand","invasion","is","the","process","in","which","the","nucleoprotein","complex","(","composed","of","the","broken","single-strand","DNA","and","the","recombinase",")","searches","and","identifies","a","region","of","homology","in","intact","duplex","DNA",".","The","broken","single-strand","DNA","displaces","the","like","strand","and","forms","Watson-Crick","base","pairs","with","its","complement",",","forming","a","duplex","in","which","each","strand","is","from","one","of","the","two","recombining","DNA","molecules","."),4116444). assertion_content_comment('tOboGo_NegativeRegulationOfStressFiberAssembly',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","assembly","a","stress","fiber",",","a","bundle","of","microfilaments","and","other","proteins","found","in","fibroblasts","."),4119134). assertion_content_comment('tOboGo_NegativeRegulationOfStriatedMuscleCellApoptosis',s("Any","process","that","increases","the","rate","or","extent","of","striated","muscle","cell","apoptosis",".","Striated","muscle","cell","apoptosis","is","a","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","striated","muscle","cell","and","result","in","its","death","."),4026259). assertion_content_comment('tOboGo_NegativeRegulationOfStriatedMuscleCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","striated","muscle","cell","differentiation","."),4036719). assertion_content_comment('tOboGo_NegativeRegulationOfStriatedMuscleContraction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","striated","muscle","contraction","."),4040058). assertion_content_comment('tOboGo_NegativeRegulationOfStriatedMuscleTissueDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","striated","muscle","development","."),4039839). assertion_content_comment('tOboGo_NegativeRegulationOfSulfurAminoAcidMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","sulfur","amino","acids","."),4031129). assertion_content_comment('tOboGo_NegativeRegulationOfSulfurMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","sulfur","or","compounds","containing","sulfur","."),4031119). assertion_content_comment('tOboGo_NegativeRegulationOfSulfurUtilization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","sulfur","utilization","."),4089846). assertion_content_comment('tOboGo_NegativeRegulationOfSuperoxideAnionGeneration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","enzymatic","generation","of","superoxide","by","a","cell","."),4064185). assertion_content_comment('tOboGo_NegativeRegulationOfSurvivalGeneProductExpression',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","survival","gene","product","expression",";","survival","gene","products","are","those","that","antagonize","the","apoptotic","program",".","Regulation","can","be","at","the","transcriptional",",","translational",",","or","posttranslational","level","."),4253373). assertion_content_comment('tOboGo_NegativeRegulationOfSymbiontCellWallStrengtheningInvolvedInEntryIntoHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","cell","wall","strengthening","during","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147303). assertion_content_comment('tOboGo_NegativeRegulationOfSymbiontGermTubeHookStructureFormationOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","germ","tube","hook","structure","formation","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147470). assertion_content_comment('tOboGo_NegativeRegulationOfSymbiontHaustoriumNeckFormationForEntryIntoHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","haustorium","neck","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146140). assertion_content_comment('tOboGo_NegativeRegulationOfSymbiontInvasiveHyphaFormationInHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","invasive","hypha","formation","within","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147287). assertion_content_comment('tOboGo_NegativeRegulationOfSymbiontPenetrationHyphaFormationForEntryIntoHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","penetration","hypha","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146168). assertion_content_comment('tOboGo_NegativeRegulationOfSymbiontPenetrationPegFormationForEntryIntoHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","penetration","peg","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147258). assertion_content_comment('tOboGo_NegativeRegulationOfSymbiontPenetrationPegInitiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","symbiont","penetration","peg","initiation",",","the","process","in","which","a","relatively","unspecialized","cell","starts","to","acquire","the","characteristics","of","a","mature","penetration","peg","during","the","symbiont","penetrating","into","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147262). assertion_content_comment('tOboGo_NegativeRegulationOfSymbiontTranscriptionInResponseToHost',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","its","transcription","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152489). assertion_content_comment('tOboGo_NegativeRegulationOfSynapseMaturation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","synapse","maturation","."),4139891). assertion_content_comment('tOboGo_NegativeRegulationOfSynapseStructuralPlasticity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","synapse","structural","plasticity","."),4282677). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticGrowthAtNeuromuscularJunction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","synaptic","growth","at","neuromuscular","junction","."),4089942). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticMetaplasticity',s("A","process","that","decreases","synaptic","metaplasticity",".","Metaplasticity","is","a","higher-order","form","of","plasticity","and","is","manifest","as","a","change","in","the","ability","to","induce","subsequent","synaptic","plasticity","that","is","the","ability","of","synapses","to","change","as","circumstances","require","."),4320260). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticPlasticity',s("A","process","that","decreases","synaptic","plasticity",",","the","ability","of","synapses","to","change","as","circumstances","require",".","They","may","alter","function",",","such","as","increasing","or","decreasing","their","sensitivity",",","or","they","may","increase","or","decrease","in","actual","numbers","."),4320219). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticTransmissionCholinergic',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","cholinergic","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","acetylcholine","."),4054262). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticTransmissionDopaminergic',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","dopaminergic","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","dopamine","."),4054425). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticTransmissionGABAergic',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","GABAergic","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","gamma-aminobutyric","acid","(","GABA",")"),4054410). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticTransmissionGlutamatergic',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","glutamatergic","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","glutamate","."),4120707). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticTransmissionGlycinergic',s("Any","process","that","stops","or","decreases","the","frequency",",","rate","or","extent","of","glycinergic","synaptic","transmission",".","Glycinergic","synaptic","transmission","is","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","glycine","."),4108804). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticTransmission',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","a","target","(","neuron",",","muscle",",","or","secretory","cell",")","across","a","synapse","."),4054255). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticVesicleExocytosis',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","synaptic","vesicle","exocytosis","."),4139867). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticVesicleFusionToPresynapticMembrane',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","synaptic","vesicle","fusion","to","the","presynaptic","membrane","."),4059934). assertion_content_comment('tOboGo_NegativeRegulationOfSynapticVesiclePriming',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","synaptic","vesicle","priming",".","Synaptic","vesicle","priming","is","the","formation","of","SNARE-containing","complexes",",","bringing","synaptic","vesicle","membrane","and","plasma","membranes","into","close","proximity","and","thereby","facilitating","membrane","fusion","."),4026005). assertion_content_comment('tOboGo_NegativeRegulationOfSynaptogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","synaptogenesis",",","the","formation","of","a","synapse","."),4089935). assertion_content_comment('tOboGo_NegativeRegulationOfSyncytialBlastodermMitoticCellCycle',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","progression","through","the","syncytial","blastoderm","mitotic","cell","cycle","."),4092004). assertion_content_comment('tOboGo_NegativeRegulationOfSyncytiumFormationByPlasmaMembraneFusion',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","formation","of","a","syncytium",",","a","mass","of","cytoplasm","containing","several","nuclei","enclosed","within","a","single","plasma","membrane",",","by","the","fusion","of","the","plasma","membranes","of","two","or","more","individual","cells","."),4075730). assertion_content_comment('tOboGo_NegativeRegulationOfSynergidDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","synergid","cell","differentiation","."),4091788). assertion_content_comment('tOboGo_NegativeRegulationOfSystemicAcquiredResistance',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","systemic","acquired","resistance","."),4032930). assertion_content_comment('tOboGo_NegativeRegulationOfSystemicArterialBloodPressure',s("The","process","that","reduces","the","force","with","which","blood","travels","through","the","systemic","arterial","circulatory","system","."),3987388). assertion_content_comment('tOboGo_NegativeRegulationOfTCellActivation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","T","cell","activation","."),4066168). assertion_content_comment('tOboGo_NegativeRegulationOfTCellAnergy',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","T","cell","anergy","."),3998343). assertion_content_comment('tOboGo_NegativeRegulationOfTCellAntigenProcessingAndPresentation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","T","cell","antigen","processing","and","presentation","."),3994398). assertion_content_comment('tOboGo_NegativeRegulationOfTCellApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","T","cell","death","by","apoptosis","."),4137006). assertion_content_comment('tOboGo_NegativeRegulationOfTCellCostimulation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","T","cell","costimulation","."),4144752). assertion_content_comment('tOboGo_NegativeRegulationOfTCellCytokineProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","T","cell","cytokine","production","."),3998574). assertion_content_comment('tOboGo_NegativeRegulationOfTCellDifferentiationInThymus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","T","cell","differentiation","in","the","thymus","."),4066189). assertion_content_comment('tOboGo_NegativeRegulationOfTCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","T","cell","differentiation","."),4066178). assertion_content_comment('tOboGo_NegativeRegulationOfTCellExtravasation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","T","cell","extravasation","."),4142234). assertion_content_comment('tOboGo_NegativeRegulationOfTCellHomeostaticProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","resting","T","cell","proliferation","."),4091878). assertion_content_comment('tOboGo_NegativeRegulationOfTCellMediatedCytotoxicityDirectedAgainstTumorCellTarget',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","T","cell","mediated","cytotoxicity","directed","against","a","tumor","cell","target","."),4000388). assertion_content_comment('tOboGo_NegativeRegulationOfTCellMediatedCytotoxicity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","T","cell","mediated","cytotoxicity","."),3989556). assertion_content_comment('tOboGo_NegativeRegulationOfTCellMediatedImmuneResponseToTumorCell',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","T","cell","mediated","immune","response","to","tumor","cell","."),4000376). assertion_content_comment('tOboGo_NegativeRegulationOfTCellMediatedImmunity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","T","cell","mediated","immunity","."),3984126). assertion_content_comment('tOboGo_NegativeRegulationOfTCellMigration',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","T","cell","migration","."),4142227). assertion_content_comment('tOboGo_NegativeRegulationOfTCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","T","cell","proliferation","."),4066226). assertion_content_comment('tOboGo_NegativeRegulationOfTCellReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signaling","pathways","initiated","by","the","cross-linking","of","an","antigen","receptor","on","a","T","cell","."),4052481). assertion_content_comment('tOboGo_NegativeRegulationOfTCellToleranceInduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","T","cell","tolerance","induction","."),3995211). assertion_content_comment('tOboGo_NegativeRegulationOfTCellToleranceInductionToTumorCell',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","T","cell","tolerance","induction","to","tumor","cell","."),4000965). assertion_content_comment('tOboGo_NegativeRegulationOfTeliosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","teliospore","formation",",","which","is","the","formation","of","a","thick-walled","resting","or","overwintering","spore","produced","by","the","rust","fungi","(","Uredinales",")","and","smut","fungi","(","Ustilaginales",")","in","which","karyogamy","occurs","."),4148517). assertion_content_comment('tOboGo_NegativeRegulationOfTeliumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","telium","development",",","a","process","that","leads","to","the","formation","of","a","teliospore-bearing","sorus","of","the","rust","fungi","."),4148353). assertion_content_comment('tOboGo_NegativeRegulationOfTelomeraseActivity',s("Any","process","that","stops","or","reduces","the","activity","of","the","enzyme","telomerase",",","which","catalyzes","of","the","reaction",":","deoxynucleoside","triphosphate","+","DNA","(","n",")","=","diphosphate","+","DNA","(","n","+","1",")"),4183744). assertion_content_comment('tOboGo_NegativeRegulationOfTelomereMaintenance',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","process","that","affects","and","monitors","the","activity","of","telomeric","proteins","and","the","length","of","telomeric","DNA","."),4055095). assertion_content_comment('tOboGo_NegativeRegulationOfTelomereMaintenanceViaRecombination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","a","recombinational","process","involved","in","the","maintenance","of","proper","telomeric","length","."),4055216). assertion_content_comment('tOboGo_NegativeRegulationOfTelomereMaintenanceViaTelomerase',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","addition","of","telomeric","repeats","by","telomerase","."),4055142). assertion_content_comment('tOboGo_NegativeRegulationOfTerminalCellFateSpecificationOpenTrachealSystem',s("Any","process","that","restricts",",","stops","or","prevents","a","cell","from","adopting","a","terminal","cell","fate","in","an","open","tracheal","system",".","Once","the","terminal","and","fusion","fates","have","been","correctly","induced",",","inhibitory","feedback","loops","prevent","the","remaining","branch","cells","from","assuming","similar","fates","."),4071815). assertion_content_comment('tOboGo_NegativeRegulationOfTesticularBloodVesselMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","blood","vessel","morphogenesis","in","the","testicle","."),4261461). assertion_content_comment('tOboGo_NegativeRegulationOfTestosteroneBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","testosterone","biosynthetic","process","."),4140930). assertion_content_comment('tOboGo_NegativeRegulationOfTheForceOfHeartContractionByAcetylcholine',s("The","process","in","which","acetylcholine","released","from","vagus","nerve","endings","binds","to","muscarinic","receptors","and","decreases","the","force","of","heart","muscle","contraction","."),4003893). assertion_content_comment('tOboGo_NegativeRegulationOfTheForceOfHeartContractionByChemicalSignal',s("Any","process","which","decreases","the","force","of","heart","muscle","contraction","mediated","by","chemical","signaling",",","hormonal",",","autocrine","or","paracrine","."),4003889). assertion_content_comment('tOboGo_NegativeRegulationOfTheForceOfHeartContractionInvolvedInBaroreceptorResponseToIncreasedSystemicArterialBloodPressure',s("Any","process","that","decreases","the","force","with","which","the","cardiac","muscles","of","the","heart","pump","blood","through","the","circulatory","system","as","a","result","of","the","baroreceptor","response","to","increased","blood","pressure","."),3987541). assertion_content_comment('tOboGo_NegativeRegulationOfThiamineBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","thiamine","."),4130930). assertion_content_comment('tOboGo_NegativeRegulationOfThiamineDiphosphateBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","thiamine","diphosphate","."),4130955). assertion_content_comment('tOboGo_NegativeRegulationOfThrombinReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","thrombin","receptor","protein","signaling","pathway","activity",".","A","thrombin","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","a","thrombin","receptor","binding","to","one","of","its","physiological","ligands","."),4131262). assertion_content_comment('tOboGo_NegativeRegulationOfThymidylateSynthaseBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","enzyme","thymidylate","synthase","."),4101085). assertion_content_comment('tOboGo_NegativeRegulationOfThymineTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","thymine",",","5-methyluracil",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083409). assertion_content_comment('tOboGo_NegativeRegulationOfThymocyteAggregation',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","thymocyte","aggregation","."),4142684). assertion_content_comment('tOboGo_NegativeRegulationOfThymocyteApoptosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","thymocyte","death","by","apoptosis","."),4137030). assertion_content_comment('tOboGo_NegativeRegulationOfThymocyteMigration',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","thymocyte","migration","."),4142729). assertion_content_comment('tOboGo_NegativeRegulationOfThyroidHormoneGeneration',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","thyroid","hormone","generation","."),4143728). assertion_content_comment('tOboGo_NegativeRegulationOfThyroidHormoneMediatedSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","thyroid","hormone","mediated","signaling","pathway","."),3992963). assertion_content_comment('tOboGo_NegativeRegulationOfTissueRemodeling',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","tissue","remodeling","."),4076648). assertion_content_comment('tOboGo_NegativeRegulationOfToleranceInductionDependentUponImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","tolerance","induction","dependent","upon","immune","response","."),3995293). assertion_content_comment('tOboGo_NegativeRegulationOfToleranceInduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","tolerance","induction","."),3995203). assertion_content_comment('tOboGo_NegativeRegulationOfToleranceInductionToNonselfAntigen',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","tolerance","induction","to","nonself","antigen","."),3995371). assertion_content_comment('tOboGo_NegativeRegulationOfToleranceInductionToSelfAntigen',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","tolerance","induction","to","self","antigen","."),3995406). assertion_content_comment('tOboGo_NegativeRegulationOfToleranceInductionToTumorCell',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","tolerance","induction","to","tumor","cell","."),4000947). assertion_content_comment('tOboGo_NegativeRegulationOfTollSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","Tl","signaling","pathway","."),4091167). assertion_content_comment('tOboGo_NegativeRegulationOfTonicSkeletalMuscleContraction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","tonic","skeletal","muscle","contraction","."),4040065). assertion_content_comment('tOboGo_NegativeRegulationOfToothMineralization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","tooth","mineralization",",","the","deposition","of","calcium","salts","in","tooth","structures","."),4133440). assertion_content_comment('tOboGo_NegativeRegulationOfTORSignalingCascade',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","signaling","via","the","TOR","signaling","pathway","."),4057842). assertion_content_comment('tOboGo_NegativeRegulationOfTRAILBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","TRAIL",",","TNF-related","apoptosis","inducing","ligand","."),4088135). assertion_content_comment('tOboGo_NegativeRegulationOfTRAILProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","TRAIL","production","."),4068463). assertion_content_comment('tOboGo_NegativeRegulationOfTRAILReceptor1BiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","TRAIL","(","TNF-related","apoptosis","inducing","ligand",")","receptor","1","."),4088047). assertion_content_comment('tOboGo_NegativeRegulationOfTRAILReceptor2BiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","TRAIL","(","TNF-related","apoptosis","inducing","ligand",")","receptor","2","."),4088028). assertion_content_comment('tOboGo_NegativeRegulationOfTRAILReceptorBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","TRAIL","(","TNF-related","apoptosis","inducing","ligand",")","receptor","."),4087884). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionByCompetitivePromoterBinding',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","DNA-dependent","transcription","using","a","mechanism","that","involves","direct","competition","for","interaction","with","a","promoter","binding","site","."),4336108). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionByGalactose',s("Any","process","involving","galactose","that","stops",",","prevents","or","reduces","the","rate","of","transcription","."),4362685). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionByGlucose',s("Any","process","involving","glucose","that","stops",",","prevents","or","reduces","the","rate","of","transcription",".","The","presence","of","glucose","in","the","growth","medium","inhibits","the","synthesis","of","certain","enzymes","in","bacteria","growing","on","the","medium",".","For","example",",","transcription","of","some","catabolic","operons","is","under","negative","control","by","specific","repressors","and","glucose","is","an","anti-inducer","of","xylose","utilization","and","glycerol","kinase","."),4300542). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionByPheromones',s("Any","process","involving","pheromones","that","stops",",","prevents","or","reduces","the","rate","of","transcription","."),4298008). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionByTranscriptionFactorCatabolism',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","DNA-dependent","transcription","using","a","mechanism","that","involves","the","catabolism","of","a","transcription","factor","."),4336574). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionByTranscriptionFactorLocalization',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","DNA-dependent","transcription","using","a","mechanism","that","involves","the","localization","of","a","transcription","factor","."),4336584). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionDuringMeiosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","during","meiosis","."),4286949). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionDuringMitosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","during","mitosis","."),4235160). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionElongationFromRNAPolymeraseIIPromoter',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","elongation",",","the","extension","of","an","RNA","molecule","after","transcription","initiation","and","promoter","clearance","by","the","addition","of","ribonucleotides",",","catalyzed","by","RNA","polymerase","II","."),4075768). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFactorImportIntoNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","movement","of","a","transcription","factor","from","the","cytoplasm","to","the","nucleus","."),4016407). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIIPromoterDuringMitosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","III","promoter","during","mitosis","."),4235183). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIIPromoter',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","III","promoter","."),4034293). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterByGalactose',s("Any","process","involving","galactose","that","stops",",","prevents","or","reduces","the","rate","of","transcription","from","an","RNA","polymerase","II","promoter","."),4362693). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterByGlucose',s("Any","process","involving","glucose","that","stops",",","prevents","or","reduces","the","rate","of","transcription","from","an","RNA","polymerase","II","promoter","."),4362718). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterByNuclearHormoneReceptor',s("Any","process","in","which","a","ligand-bound","hormone","receptor","acts","in","the","nucleus","to","stop",",","prevent",",","or","reduce","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4156842). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterByPheromones',s("Any","process","involving","pheromones","that","stops",",","prevents","or","reduces","the","rate","of","transcription","from","an","RNA","polymerase","II","promoter","."),4348171). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterDuringMeiosis',s("A","cell","cycle","process","that","decreases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","during","meiosis","."),4336394). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterDuringMitosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","during","mitosis","."),4235214). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterGlobal',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","global","transcription","from","an","RNA","polymerase","II","promoter","."),4297723). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterInResponseToIronIonStarvation',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","as","a","result","of","a","stimulus","indicating","the","organism","is","deprived","of","iron","ions","."),4155284). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoterInResponseToIron',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","of","transcription","from","an","RNA","polymerase","II","promoter","in","response","to","an","iron","stimulus","."),4357125). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIIPromoter',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),3971650). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIPromoterDuringMitosis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","I","promoter","during","mitosis","."),4235268). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionFromRNAPolymeraseIPromoter',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","I","promoter","."),4034309). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionInitiationFromRNAPolymeraseIIPromoter',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","a","process","involved","in","starting","transcription","from","the","RNA","polymerase","II","promoter","."),4111696). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionInvolvedInG1PhaseOfMitoticCellCycle',s("Any","process","that","stop",",","prevents","or","decreases","transcription","as","part","of","the","G1","phase","of","the","mitotic","cell","cycle","."),4159947). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionInvolvedInG1SPhaseOfMitoticCellCycle',s("Any","process","that","stop",",","prevents","or","decreases","transcription","as","part","of","the","G1/S","transition","of","the","mitotic","cell","cycle","."),4167953). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionOfHomeoticGenePolycombGroup',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","of","homeotic","genes","of","the","Polycomb","group","."),4222571). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionOfHomeoticGeneTrithoraxGroup',s("OBSOLETE",".","Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transcription","of","homeotic","genes","of","the","trithorax","group","."),4298254). assertion_content_comment('tOboGo_NegativeRegulationOfTranscriptionRegulatorActivity',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","transcription","regulator","activity",",","any","molecular","function","that","plays","a","role","in","regulating","transcription",";","may","bind","a","promoter","or","enhancer","DNA","sequence","or","interact","with","a","DNA-binding","transcription","factor","."),4154859). assertion_content_comment('tOboGo_NegativeRegulationOfTransferaseActivity',s("Any","process","that","stops","or","reduces","the","rate","of","transferase","activity",",","the","catalysis","of","the","transfer","of","a","group",",","e.g",".","a","methyl","group",",","glycosyl","group",",","acyl","group",",","phosphorus-containing",",","or","other","groups",",","from","a","donor","compound","to","an","acceptor","."),3972866). assertion_content_comment('tOboGo_NegativeRegulationOfTransformingGrowthFactorBetaReceptorSignalingPathwayByExtracellularSequesteringOfTGFbeta',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","any","TGFbeta","receptor","signaling","pathway","by","binding","or","confining","a","TGFbeta","protein","within","the","extracellular","region","such","that","it","is","separated","from","other","components","of","the","signaling","pathway","."),4378312). assertion_content_comment('tOboGo_NegativeRegulationOfTransformingGrowthFactorBetaReceptorSignalingPathwayInvolvedInPrimitiveStreakFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","any","TGF-beta","receptor","signaling","pathway","that","contributes","to","the","formation","of","the","primitive","streak","."),4149715). assertion_content_comment('tOboGo_NegativeRegulationOfTransformingGrowthFactorBetaReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","any","TGF-beta","receptor","signaling","pathway","."),4046774). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationalElongation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","translational","elongation","."),4089978). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationalFidelity',s("Any","process","that","decreases","the","ability","of","the","translational","apparatus","to","interpret","the","genetic","code","."),4298092). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationalInitiationByIron',s("Any","process","involving","iron","that","stops",",","prevents","or","reduces","the","rate","of","translational","initiation","."),4298039). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationalInitiationInResponseToOsmoticStress',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","of","translation","initiation",",","as","a","result","of","a","stimulus","indicating","an","increase","or","decrease","in","the","concentration","of","solutes","outside","the","organism","or","cell","."),4330389). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationalInitiationInResponseToStarvation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","of","translation","initiation",",","as","a","result","of","deprivation","of","nourishment","."),4165506). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationalInitiationInResponseToStress',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","of","translation","initiation","as","a","result","of","a","stimulus","indicating","the","organism","is","under","stress","."),4165488). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationalInitiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","translational","initiation","."),4092738). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationalTermination',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","translational","termination","."),4090099). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationInResponseToNitrogenStarvation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","of","translation","as","a","result","of","a","stimulus","indicating","deprivation","of","nitrogen","."),4173088). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationInResponseToOsmoticStress',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","of","translation","as","a","result","of","a","stimulus","indicating","an","increase","or","decrease","in","the","concentration","of","solutes","outside","the","organism","or","cell","."),4330363). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationInResponseToOxidativeStress',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","translation","as","a","result","of","oxidative","stress",",","a","state","often","resulting","from","exposure","to","high","levels","of","reactive","oxygen","species",",","e.g",".","superoxide","anions",",","hydrogen","peroxide","(","H2O2",")",",","and","hydroxyl","radicals","."),4336963). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationInResponseToStress',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","of","translation","as","a","result","of","a","stimulus","indicating","the","organism","is","under","stress","."),4165480). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationInvolvedInGeneSilencingByMiRNA',s("The","process","in","which","microRNAs","(","miRNAs",")","block","the","translation","of","target","mRNAs","into","proteins",".","Once","incorporated","into","a","RNA-induced","silencing","complex","(","RISC",")",",","a","miRNA","will","typically","repress","translation","if","the","miRNA","imperfectly","base-pairs","with","the","3","'","untranslated","regions","of","target","mRNAs","."),4070992). assertion_content_comment('tOboGo_NegativeRegulationOfTranslationInvolvedInRNAInterference',s("A","process","of","negative","regulation","of","translation","that","is","mediated","by","the","association","of","small","interfering","RNAs","(","siRNAs",")","with","a","cognate","target","mRNA","."),4131079). assertion_content_comment('tOboGo_NegativeRegulationOfTranslation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","proteins","by","the","translation","of","mRNA","."),4040976). assertion_content_comment('tOboGo_NegativeRegulationOfTransmembraneReceptorProteinSerineThreonineKinaseSignalingPathway',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","series","of","molecular","signals","generated","as","a","consequence","of","a","transmembrane","receptor","serine/threonine","kinase","binding","to","its","physiological","ligand","."),4035940). assertion_content_comment('tOboGo_NegativeRegulationOfTransmembraneTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","solute","from","one","side","of","a","membrane","to","the","other","."),4016344). assertion_content_comment('tOboGo_NegativeRegulationOfTransmissionOfNerveImpulse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transmission","of","a","nerve","impulse",",","the","sequential","electrochemical","polarization","and","depolarization","that","travels","across","the","membrane","of","a","neuron","in","response","to","stimulation","."),4054249). assertion_content_comment('tOboGo_NegativeRegulationOfTransporterActivity',s("Any","process","that","stops","or","reduces","the","activity","of","a","transporter","."),4160467). assertion_content_comment('tOboGo_NegativeRegulationOfTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","(","such","as","macromolecules",",","small","molecules",",","ions",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3989895). assertion_content_comment('tOboGo_NegativeRegulationOfTransposition',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","transposition",".","Transposition","results","in","the","movement","of","discrete","segments","of","DNA","between","nonhomologous","sites","."),3975163). assertion_content_comment('tOboGo_NegativeRegulationOfTransposonIntegration',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","transposon","integration",",","a","process","in","which","a","transposable","element","is","incorporated","into","another","DNA","molecule","."),4132013). assertion_content_comment('tOboGo_NegativeRegulationOfTrichoblastFateSpecification',s("Any","process","that","suppresses","trichoblast","fate","specification","."),4032764). assertion_content_comment('tOboGo_NegativeRegulationOfTriglycerideBiosyntheticProcess',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","triglyceride","biosynthesis",".","Triglyceride","biosynthesis","is","the","collection","of","chemical","reactions","and","pathways","resulting","in","the","formation","of","triglyceride",",","any","triester","of","glycerol","."),4037246). assertion_content_comment('tOboGo_NegativeRegulationOfTriglycerideCatabolicProcess',s("Any","process","that","decreases","the","frequency",",","rate",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","triglyceride","."),4037993). assertion_content_comment('tOboGo_NegativeRegulationOfTriglycerideMetabolicProcess',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","triglyceride",",","any","triester","of","glycerol","."),4037243). assertion_content_comment('tOboGo_NegativeRegulationOfTRNAExportFromNucleus',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","tRNA","export","from","nucleus","."),4140700). assertion_content_comment('tOboGo_NegativeRegulationOfTRNAProcessing',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","tRNA","processing","."),4140676). assertion_content_comment('tOboGo_NegativeRegulationOfTrophoblastCellDifferentiationByTranscriptionRegulationFromRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","ultimately","resulting","in","a","decrease","in","trophoblast","stem","cells","differentiating","into","the","more","mature","cells","of","the","trophoblast","."),4156521). assertion_content_comment('tOboGo_NegativeRegulationOfTrophoblastCellDifferentiationByTransformingGrowthFactorBetaSignalingPathway',s("The","transforming","growth","factor","signaling","process","that","decreases","the","rate",",","frequency",",","or","extent","of","trophoblast","stem","cells","differentiating","into","the","more","mature","cells","of","the","trophoblast","."),4156541). assertion_content_comment('tOboGo_NegativeRegulationOfTumorNecrosisFactorBiosyntheticProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","tumor","necrosis","factor",",","an","inflammatory","cytokine","produced","by","macrophages/monocytes","during","acute","inflammation","and","which","is","responsible","for","a","diverse","range","of","signaling","events","within","cells",",","leading","to","necrosis","or","apoptosis","."),4077522). assertion_content_comment('tOboGo_NegativeRegulationOfTumorNecrosisFactorLigandSuperfamilyMember11Production',s("Any","process","that","stops",",","prevents","or","reduces","the","frequency",",","rate","or","extent","of","tumor","necrosis","factor","(","ligand",")","superfamily","member","11","production","."),4139769). assertion_content_comment('tOboGo_NegativeRegulationOfTumorNecrosisFactorProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","tumor","necrosis","factor","production","."),4068506). assertion_content_comment('tOboGo_NegativeRegulationOfTurningBehaviorInvolvedInMating',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","turning","behavior","involved","in","mating",".","Turning","behavior","is","the","sharp","ventral","turn","performed","by","the","male","as","he","approaches","either","the","hermaphrodite","head","or","tail",",","whilst","trying","to","locate","his","partner","'","s","vulva",".","Turning","occurs","via","a","sharp","ventral","coil","of","the","male","'","s","tail","."),4135417). assertion_content_comment('tOboGo_NegativeRegulationOfType2ImmuneResponse',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","a","type","2","immune","response","."),4000749). assertion_content_comment('tOboGo_NegativeRegulationOfTypeBPancreaticCellDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","pancreatic","B","cell","development","."),4138528). assertion_content_comment('tOboGo_NegativeRegulationOfTypeIHypersensitivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","type","I","hypersensitivity",",","a","type","of","inflammatory","response","."),3984153). assertion_content_comment('tOboGo_NegativeRegulationOfTypeIIaHypersensitivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","type","IIa","hypersensitivity",",","a","type","of","inflammatory","response","."),3984003). assertion_content_comment('tOboGo_NegativeRegulationOfTypeIIbHypersensitivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","type","IIb","hypersensitivity",",","a","type","of","inflammatory","response","."),3984514). assertion_content_comment('tOboGo_NegativeRegulationOfTypeIIHypersensitivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","type","II","hypersensitivity","."),3983996). assertion_content_comment('tOboGo_NegativeRegulationOfTypeIIIHypersensitivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","type","III","hypersensitivity",",","a","type","of","inflammatory","response","."),3984460). assertion_content_comment('tOboGo_NegativeRegulationOfTypeIIIInterferonProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","type","III","interferon","production",".","Type","III","interferons","are","members","of","the","interferon-lambda","gene","family","."),4075229). assertion_content_comment('tOboGo_NegativeRegulationOfTypeIInterferonProduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate",",","or","extent","of","type","I","interferon","production",".","Type","I","interferons","include","the","interferon-alpha",",","beta",",","delta",",","episilon",",","zeta",",","kappa",",","tau",",","and","omega","gene","families","."),4055883). assertion_content_comment('tOboGo_NegativeRegulationOfTypeIVHypersensitivity',s("Any","process","that","stops",",","prevents",",","or","reduces","the","rate","of","type","IV","hypersensitivity",",","a","type","of","inflammatory","response","."),3984137). assertion_content_comment('tOboGo_NegativeRegulationOfTyramineSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","tyramine","signaling","pathway","."),4138073). assertion_content_comment('tOboGo_NegativeRegulationOfTyrosinePhosphorylationOfStat1Protein',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat1","protein","."),4079087). assertion_content_comment('tOboGo_NegativeRegulationOfTyrosinePhosphorylationOfStat2Protein',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat2","protein","."),4079121). assertion_content_comment('tOboGo_NegativeRegulationOfTyrosinePhosphorylationOfStat3Protein',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat3","protein","."),4079206). assertion_content_comment('tOboGo_NegativeRegulationOfTyrosinePhosphorylationOfStat4Protein',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat4","protein","."),4079237). assertion_content_comment('tOboGo_NegativeRegulationOfTyrosinePhosphorylationOfStat5Protein',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat5","protein","."),4078859). assertion_content_comment('tOboGo_NegativeRegulationOfTyrosinePhosphorylationOfStat6Protein',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat6","protein","."),4078993). assertion_content_comment('tOboGo_NegativeRegulationOfTyrosinePhosphorylationOfStat7Protein',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat7","protein","."),4079008). assertion_content_comment('tOboGo_NegativeRegulationOfTyrosinePhosphorylationOfSTATProtein',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","STAT","(","Signal","Transducer","and","Activator","of","Transcription",")","protein","."),4078852). assertion_content_comment('tOboGo_NegativeRegulationOfUnidimensionalCellGrowth',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","unidimensional","cell","growth",",","the","process","in","which","a","cell","irreversibly","increases","in","size","in","one","[","spatial","]","dimension","or","along","one","axis","."),4118684). assertion_content_comment('tOboGo_NegativeRegulationOfUrediniumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","uredinium","development",",","a","process","that","leads","to","the","formation","of","a","reddish",",","pustule-like","structure","formed","by","a","rust","fungus","and","consisting","of","uredospores","."),4148323). assertion_content_comment('tOboGo_NegativeRegulationOfUredosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","uredospore","formation",",","a","process","in","which","an","asexual",",","dikaryotic",",","often","rusty-colored","spore",",","is","formed","in","a","structure","called","a","uredinium","."),4148561). assertion_content_comment('tOboGo_NegativeRegulationOfUreterSmoothMuscleCellDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","ureter","smooth","muscle","cell","differentiation","."),4138807). assertion_content_comment('tOboGo_NegativeRegulationOfUrineVolume',s("Any","process","that","decreases","the","amount","of","urine","excreted","from","the","body","over","a","unit","of","time","."),4081170). assertion_content_comment('tOboGo_NegativeRegulationOfUrothelialCellProliferation',s("Any","process","that","stops",",","prevents","or","reduces","the","rate","or","extent","of","urothelial","cell","proliferation","."),4101491). assertion_content_comment('tOboGo_NegativeRegulationOfUterineSmoothMuscleContraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","uterine","smooth","muscle","contraction","."),4131453). assertion_content_comment('tOboGo_NegativeRegulationOfVascularEndothelialGrowthFactorReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","vascular","endothelial","growth","factor","receptor","signaling","pathway","activity","."),4061555). assertion_content_comment('tOboGo_NegativeRegulationOfVascularPermeability',s("Any","process","that","reduces","the","extent","to","which","blood","vessels","can","be","pervaded","by","fluid","."),4317774). assertion_content_comment('tOboGo_NegativeRegulationOfVascularWoundHealing',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","blood","vessel","formation","when","new","vessels","emerge","from","the","proliferation","of","pre-existing","blood","vessels","and","contribute","to","the","series","of","events","that","restore","integrity","to","damaged","vasculature","."),4113468). assertion_content_comment('tOboGo_NegativeRegulationOfVasoconstriction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","vasoconstriction","."),4090035). assertion_content_comment('tOboGo_NegativeRegulationOfVasodilation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","vasodilation","."),4090066). assertion_content_comment('tOboGo_NegativeRegulationOfVernalizationResponse',s("Any","process","that","stops",",","prevents","or","reduces","the","vernalization","response",",","by","which","induction","of","flowering","is","normally","caused","by","extended","exposure","to","cold","temperatures","."),4031873). assertion_content_comment('tOboGo_NegativeRegulationOfVesicleFusion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","vesicle","fusion","."),4059253). assertion_content_comment('tOboGo_NegativeRegulationOfViralGenomeReplication',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","viral","genome","replication","."),4090355). assertion_content_comment('tOboGo_NegativeRegulationOfViralProteinLevelsInHostCell',s("Any","process","that","reduces","the","levels","of","viral","proteins","in","a","cell","."),4357014). assertion_content_comment('tOboGo_NegativeRegulationOfViralReproduction',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","viral","life","cycle",",","the","set","of","processes","by","which","a","virus","reproduces","and","spreads","among","hosts","."),4090346). assertion_content_comment('tOboGo_NegativeRegulationOfViralTranscription',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","viral","transcription","."),4064779). assertion_content_comment('tOboGo_NegativeRegulationOfVirionPenetrationIntoHostCell',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","introduction","of","virus","particles","into","the","cell","."),4098795). assertion_content_comment('tOboGo_NegativeRegulationOfVitaminDBiosyntheticProcess',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","a","vitamin","D","biosynthetic","process",".","Vitamin","D","biosynthesis","is","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","vitamin","D",",","any","of","a","group","of","related",",","fat-soluble","compounds","that","are","derived","from","delta-5",",","7","steroids","and","play","a","central","role","in","calcium","metabolism",".","Specific","forms","of","vitamin","D","include","calciferol","(","ergocalciferol",";","vitamin","D2",")","and","cholecalciferol","(","calciol",";","vitamin","D3",")"),4035257). assertion_content_comment('tOboGo_NegativeRegulationOfVitaminDReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","vitamin","D","receptor","signaling","pathway","activity","."),4131223). assertion_content_comment('tOboGo_NegativeRegulationOfVitaminMetabolicProcess',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","vitamin",",","one","of","a","number","of","unrelated","organic","substances","that","occur","in","many","foods","in","small","amounts","and","that","are","necessary","in","trace","amounts","for","the","normal","metabolic","functioning","of","the","body","."),4035236). assertion_content_comment('tOboGo_NegativeRegulationOfVulvalDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","development","of","the","vulva",".","Vulval","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","egg-laying","organ","of","female","and","hermaphrodite","nematodes","over","time",",","from","its","formation","to","the","mature","structure",".","In","nematodes",",","the","vulva","is","formed","from","ventral","epidermal","cells","during","larval","stages","to","give","rise","to","a","fully","formed","vulva","in","the","adult","."),4081908). assertion_content_comment('tOboGo_NegativeRegulationOfWhiteFatCellProliferation',s("Any","process","that","stops","or","decreases","the","rate","or","extent","of","white","fat","cell","proliferation","."),4136671). assertion_content_comment('tOboGo_NegativeRegulationOfWntProteinSecretion',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","controlled","release","of","a","Wnt","protein","from","a","cell","or","group","of","cells","."),4133778). assertion_content_comment('tOboGo_NegativeRegulationOfWntReceptorSignalingPathwayCalciumModulatingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","leads","to","an","increase","in","intracellular","calcium","and","activation","of","protein","kinase","C","(","PKC",")"),4090513). assertion_content_comment('tOboGo_NegativeRegulationOfWntReceptorSignalingPathwayInvolvedInDigestiveTractMorphogenesis',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Wnt","receptor","signaling","pathway","involved","in","digestive","tract","morphogenesis","."),4139189). assertion_content_comment('tOboGo_NegativeRegulationOfWntReceptorSignalingPathwayInvolvedInDorsalVentralAxisSpecification',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Wnt","receptor","signaling","pathway","involved","in","dorsal/ventral","axis","specification","."),4139152). assertion_content_comment('tOboGo_NegativeRegulationOfWntReceptorSignalingPathwayInvolvedInHeartDevelopment',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","series","of","molecular","signals","initiated","by","binding","of","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","resulting","a","change","in","cell","state","that","contributes","to","the","progression","of","the","heart","over","time","."),4001871). assertion_content_comment('tOboGo_NegativeRegulationOfWntReceptorSignalingPathway',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","Wnt","receptor","signaling","pathway","activity","."),4001857). assertion_content_comment('tOboGo_NegativeRegulationOfWoundHealing',s("Any","process","that","decreases","the","rate",",","frequency",",","or","extent","of","the","series","of","events","that","restore","integrity","to","a","damaged","tissue",",","following","an","injury","."),4113465). assertion_content_comment('tOboGo_NegativeRegulationOfXanthophoreDifferentiation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","xanthophore","differentiation","."),4100114). assertion_content_comment('tOboGo_NegativeRegulationOfZincIonImport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","zinc","ions","(","Zn2","+",")","from","one","side","of","a","membrane","to","the","other","."),4129813). assertion_content_comment('tOboGo_NegativeRegulationOfZincIonTransmembraneTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","zinc","ions","(","Zn2","+",")","from","one","side","of","a","membrane","to","the","other","."),4129810). assertion_content_comment('tOboGo_NegativeRegulationOfZincIonTransport',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","directed","movement","of","zinc","ions","(","Zn2","+",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4129807). assertion_content_comment('tOboGo_NegativeRegulationOfZoosporeEncystmentOnHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","zoospore","encystment","on","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146239). assertion_content_comment('tOboGo_NegativeRegulationOfZoosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","zoospore","formation",",","a","process","in","which","a","diploid","cell","undergoes","meiosis",",","and","the","meiotic","products","acquire","specialized","features","of","asexual","motile","mononucleate","flagellated","spores","called","zoospores","."),4148686). assertion_content_comment('tOboGo_NegativeRegulationOfZoosporeMovementOnOrNearHost',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","zoospore","movement","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146544). assertion_content_comment('tOboGo_NegativeRegulationOfZygosporangiumDevelopment',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","zygosporangium","development",",","a","process","in","which","a","fruiting","body","called","zygosporangium","is","formed","."),4148405). assertion_content_comment('tOboGo_NegativeRegulationOfZygosporeFormation',s("Any","process","that","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","zygospore","formation",",","a","process","in","which","a","thick-walled","spore","of","some","algae","and","fungi","is","formed","by","union","of","two","similar","sexual","cells",",","usually","serves","as","a","resting","spore",",","and","produces","the","sporophytic","phase","."),4148187). assertion_content_comment('tOboGo_NegativeSenseViralGenome',s("A","single","stranded","RNA","genome","with","the","opposite","nucleotide","polarity","as","mRNA","."),4236438). assertion_content_comment('tOboGo_NegativeTCellSelection',s("The","process","of","elimination","of","immature","T","cells","which","react","strongly","with","self-antigens","."),4300977). assertion_content_comment('tOboGo_NegativeThymicTCellSelection',s("The","process","of","elimination","of","immature","T","cells","in","the","thymus","which","react","strongly","with","self-antigens","."),4301010). assertion_content_comment('tOboGo_NegativeTranscriptionElongationFactorActivity',s("Any","activity","that","decreases","the","rate","of","transcription","elongation",",","the","addition","of","ribonucleotides","to","an","RNA","molecule","following","transcription","initiation","."),4245863). assertion_content_comment('tOboGo_NELFComplex',s("A","complex","of","five","proteins",",","designated","NELF-A",",","-B",",","-C",",","-D",",","and","-E","in","human",",","that","can","physically","associate","with","RNP","polymerase","II","to","induce","transcriptional","pausing","."),4330674). assertion_content_comment('tOboGo_Nematocyst',s("An","organelle","found","in","cnidoblast","(","nematoblast",")","cells",".","When","matured",",","these","stinging","organelles","store","toxins","and","can","deliver","them","when","the","cnidocil","(","a","short","extension","of","the","cnidocyst",")","is","stimulated","by","a","prey","or","another","stimulus","."),4313923). assertion_content_comment('tOboGo_NematodeLarvalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","nematode","larva","over","time",",","from","its","formation","to","the","mature","structure",".","Nematode","larval","development","begins","with","the","newly","hatched","first-stage","larva","(","L1",")","and","ends","with","the","end","of","the","last","larval","stage","(","for","example","the","fourth","larval","stage","(","L4",")","in","C",".","elegans",")","Each","stage","of","nematode","larval","development","is","characterized","by","proliferation","of","specific","cell","lineages","and","an","increase","in","body","size","without","alteration","of","the","basic","body","plan",".","Nematode","larval","stages","are","separated","by","molts","in","which","each","stage-specific","exoskeleton",",","or","cuticle",",","is","shed","and","replaced","anew","."),4081848). assertion_content_comment('tOboGo_NeopullulanaseActivity',s("Catalysis","of","the","hydrolysis","of","pullulan","to","panose","(","6-a-D-glucosylmaltose",")"),4319948). assertion_content_comment('tOboGo_NeoxanthinSynthaseActivity',s("Catalysis","of","the","reaction",":","all-trans-violaxanthin","=","all-trans-neoxanthin","."),4361119). assertion_content_comment('tOboGo_NephricDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","nephric","duct","over","time",",","from","its","initial","formation","to","a","mature","structure",".","A","nephric","duct","is","a","tube","that","drains","a","primitive","kidney","."),4058776). assertion_content_comment('tOboGo_NephricDuctFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","nephric","duct",".","A","nephric","duct","is","a","tube","that","drains","a","primitive","kidney","."),4123398). assertion_content_comment('tOboGo_NephricDuctMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","nephric","duct","are","generated","and","organized",".","A","nephric","duct","is","a","tube","that","drains","a","primitive","kidney","."),4058778). assertion_content_comment('tOboGo_NephrocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","structural","and/or","functional","features","of","a","nephrocyte",".","A","nephrocyte","is","an","insect","renal","cell","that","filters","hemolymph",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","and","its","subsequent","development","to","the","mature","state","."),4261627). assertion_content_comment('tOboGo_NephrocyteJunction',s("A","tissue-specific","adherens","junction","found","between","nephrocyte","cells",".","A","nephrocyte","is","an","insect","excretory","cell","that","regulates","hemolymph","composition","by","filtration","and","filtrate","endocytosis","."),4220634). assertion_content_comment('tOboGo_NephrogenicMesenchymeDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","nephrogenic","mesenchyme","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","nephrogenic","mesenchyme","and","ends","with","the","mature","structure",".","Nephrogenic","mesenchyme","is","the","tissue","made","up","of","loosely","connected","mesenchymal","cells","in","the","nephron","."),4122869). assertion_content_comment('tOboGo_NephrogenicMesenchymeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","nephrogenic","mesenchymal","tissue","are","generated","and","organized",".","Nephrogenic","mesenchyme","is","the","tissue","made","up","of","loosely","connected","mesenchymal","cells","in","the","nephron","."),4122879). assertion_content_comment('tOboGo_NephronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","nephron","over","time",",","from","its","formation","to","the","mature","structure",".","A","nephron","is","the","functional","unit","of","the","kidney","."),4006041). assertion_content_comment('tOboGo_NephronEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","nephron","epithelium","over","time",",","from","its","formation","to","the","mature","structure",".","An","epithelium","is","a","tissue","that","covers","the","internal","or","external","surfaces","of","an","anatomical","structure",".","The","nephron","epithelium","is","a","tissue","that","covers","the","surface","of","a","nephron","."),4006072). assertion_content_comment('tOboGo_NephronEpitheliumMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","nephron","epithelium","are","generated","and","organized",".","The","nephron","epithelium","is","a","tissue","that","covers","the","surface","of","a","nephron","."),4006085). assertion_content_comment('tOboGo_NephronMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","nephron","are","generated","and","organized",".","A","nephron","is","the","functional","unit","of","the","kidney","."),4006043). assertion_content_comment('tOboGo_NephronTubuleDevelopment',s("The","progression","of","a","nephron","tubule","over","time",",","from","its","initial","formation","to","the","mature","structure",".","A","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","nephron",",","the","functional","part","of","the","kidney","."),4058862). assertion_content_comment('tOboGo_NephronTubuleEpithelialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","cells","of","the","nephron","tubule","as","it","progresses","from","its","formation","to","the","mature","state","."),4123229). assertion_content_comment('tOboGo_NephronTubuleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","nephron","tubule","from","unspecified","parts",".","A","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","nephron",",","the","functional","part","of","the","kidney","."),4059082). assertion_content_comment('tOboGo_NephronTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","nephron","tubule","are","generated","and","organized",".","A","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","nephron",",","the","functional","part","of","the","kidney","."),4058912). assertion_content_comment('tOboGo_NephrostomeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","nephrostome","over","time",",","from","its","formation","to","the","mature","structure",".","The","nephrostome","is","the","opening","of","the","pronephros","into","the","body","cavity","."),4059186). assertion_content_comment('tOboGo_NeprilysinActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","at","the","amino","group","of","hydrophobic","residues","in","insulin",",","casein",",","hemoglobin",",","and","a","number","of","other","proteins","and","polypeptides","."),4210130). assertion_content_comment('tOboGo_NerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","nerve","over","time",",","from","its","formation","to","the","mature","structure","."),4043437). assertion_content_comment('tOboGo_NerveGrowthFactorBinding',s("Interacting","selectively","and","non-covalently","with","nerve","growth","factor","."),4214081). assertion_content_comment('tOboGo_NerveGrowthFactorProcessing',s("The","generation","of","a","mature","nerve","growth","factor","by","proteolysis","of","a","precursor","."),4334765). assertion_content_comment('tOboGo_NerveGrowthFactorProduction',s("The","appearance","of","nerve","growth","factor","due","to","biosynthesis","or","secretion","by","cells","in","a","neuron","'","s","target","field",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4064563). assertion_content_comment('tOboGo_NerveGrowthFactorReceptorActivity',s("Combining","with","nerve","growth","factor",",","to","block","apoptosis","in","neurons","and","promote","nerve","growth",",","or","to","initiate","a","change","in","cell","activity","."),4332921). assertion_content_comment('tOboGo_NerveGrowthFactorReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","nerve","growth","factor","receptor","."),4217196). assertion_content_comment('tOboGo_NerveGrowthFactorReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","the","nerve","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","."),4118186). assertion_content_comment('tOboGo_NerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","nerve","to","attain","its","fully","functional","state","."),4043448). assertion_content_comment('tOboGo_NervousSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","nervous","tissue","over","time",",","from","its","formation","to","its","mature","state","."),3984942). assertion_content_comment('tOboGo_NetrinReceptorActivity',s("A","transmembrane","receptor","activity","that","responds","to","the","netrin","family","of","ligands","and","results","in","chemotaxis","when","activated","."),4215106). assertion_content_comment('tOboGo_NeuralCrestCellDevelopment',s("The","process","aimed","at","the","progression","of","a","neural","crest","cell","over","time",",","from","initial","commitment","of","the","cell","to","its","specific","fate",",","to","the","fully","functional","differentiated","cell","."),3985006). assertion_content_comment('tOboGo_NeuralCrestCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neural","crest","cell","."),3985004). assertion_content_comment('tOboGo_NeuralCrestCellFateCommitment',s("The","process","in","which","a","cell","becomes","committed","to","become","a","neural","crest","cell","."),4039049). assertion_content_comment('tOboGo_NeuralCrestCellFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","neural","crest","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4039059). assertion_content_comment('tOboGo_NeuralCrestCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","neural","crest","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4039180). assertion_content_comment('tOboGo_NeuralCrestCellMigrationInvolvedInHeartFormation',s("The","characteristic","movement","of","a","cell","from","the","dorsal","ridge","of","the","neural","tube","towards","the","heart","and","that","contributes","to","heart","formation","."),4003631). assertion_content_comment('tOboGo_NeuralCrestCellMigration',s("The","characteristic","movement","of","cells","from","the","dorsal","ridge","of","the","neural","tube","to","a","variety","of","locations","in","a","vertebrate","embryo","."),3985091). assertion_content_comment('tOboGo_NeuralCrestFormation',s("The","formation","of","the","specialized","region","of","ectoderm","between","the","neural","ectoderm","(","neural","plate",")","and","non-neural","ectoderm",".","The","neural","crest","gives","rise","to","the","neural","crest","cells","that","migrate","away","from","this","region","as","neural","tube","formation","procedes","."),4039046). assertion_content_comment('tOboGo_NeuralFoldBending',s("The","morphogenesis","of","the","neural","fold","elevations","that","results","in","the","movement","of","the","tips","of","the","elevations","towards","each","other","in","order","to","fuse","."),4041600). assertion_content_comment('tOboGo_NeuralFoldElevationFormation',s("The","process","in","which","the","lateral","borders","of","the","neural","plate","begin","to","migrate","upwards","to","form","the","neural","folds",",","caused","by","the","proliferation","of","the","underlying","mesoderm","."),4041588). assertion_content_comment('tOboGo_NeuralFoldFolding',s("The","process","of","folding","the","neuroepithelium","around","the","medial","hinge","point","to","create","the","neural","elevations",",","and","around","the","lateral","hinge","points","to","produce","convergence","of","the","folds","."),4041642). assertion_content_comment('tOboGo_NeuralFoldFormation',s("The","process","in","which","the","neural","fold","is","formed",".","The","edges","of","the","neural","plate","thicken","and","move","up","to","form","a","U-shaped","structure","called","the","neural","groove","."),3987188). assertion_content_comment('tOboGo_NeuralFoldHingePointFormation',s("The","formation","of","the","median","and","lateral","hinge","points","in","the","neural","folds",".","These","are","created","by","apical","constriction","and","basal","expansion","of","the","underlying","neural","cells",".","The","median","hinge","point","extends","for","the","entire","length","of","the","neural","tube",",","and","the","lateral","hinge","points","do","not","form","in","the","spinal","cord","region","of","the","neural","tube","."),4041664). assertion_content_comment('tOboGo_NeuralKeelFormation',s("The","formation","of","a","thickened","region","of","the","neurectoderm","that","is","roughly","triangular","in","cross","section",".","The","neural","keel","develops","from","the","neural","plate","and","develops","into","the","neural","rod",".","Neural","keel","formation","occurs","during","primary","neurulation","in","teleosts","."),4039265). assertion_content_comment('tOboGo_NeuralNucleusDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","neural","nucleus","from","its","initial","condition","to","its","mature","state",".","A","neural","nucleus","is","an","anatomical","structure","consisting","of","a","discrete","aggregate","of","neuronal","soma","."),4042483). assertion_content_comment('tOboGo_NeuralPlateAnteriorPosteriorRegionalization',s("The","process","that","regulates","the","coordinated","growth","and","differentiation","that","establishes","the","non-random","anterior-posterior","spatial","arrangement","of","the","neural","plate","."),4044885). assertion_content_comment('tOboGo_NeuralPlateAxisSpecification',s("The","pattern","specification","process","in","which","the","axes","of","the","nervous","system","are","established","."),4046504). assertion_content_comment('tOboGo_NeuralPlateDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","neural","plate","over","time",",","from","its","formation","to","the","mature","structure",".","The","neural","plate","is","a","flat",",","thickened","layer","of","ectodermal","cells",".","The","underlying","dorsal","mesoderm","signals","the","ectodermal","cells","above","it","to","elongate","into","columnar","neural","plate","cells",".","The","neural","plate","subsequently","develops","into","the","neural","tube",",","which","gives","rise","to","the","central","nervous","system","."),3987077). assertion_content_comment('tOboGo_NeuralPlateElongation',s("The","process","in","which","the","neural","plate","is","shaped","by","the","intrinsic","movement","of","the","epidermal","and","neural","plate","regions","."),4039276). assertion_content_comment('tOboGo_NeuralPlateFormation',s("The","formation","of","the","flat",",","thickened","layer","of","ectodermal","cells","known","as","the","neural","plate",".","The","underlying","dorsal","mesoderm","signals","the","ectodermal","cells","above","it","to","elongate","into","columnar","neural","plate","cells",".","The","neural","plate","subsequently","develops","into","the","neural","tube",",","which","gives","rise","to","the","central","nervous","system","."),4046481). assertion_content_comment('tOboGo_NeuralPlateMediolateralRegionalization',s("The","process","that","regulates","the","coordinated","growth","and","differentiation","that","establishes","the","non-random","mediolateral","spatial","arrangement","of","the","neural","plate","."),4046515). assertion_content_comment('tOboGo_NeuralPlateMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","neural","plate","are","generated","and","organized",".","The","neural","plate","is","a","specialized","region","of","columnar","epithelial","cells","in","the","dorsal","ectoderm","that","will","give","rise","to","nervous","system","tissue","."),3987087). assertion_content_comment('tOboGo_NeuralPlatePatternSpecification',s("The","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","neural","plate","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4044881). assertion_content_comment('tOboGo_NeuralPlateRegionalization',s("The","pattern","specification","process","that","results","in","the","subdivision","of","an","axis","or","axes","of","the","neural","plate","in","space","to","define","an","area","or","volume","in","which","specific","patterns","of","cell","differentiation","will","take","place","or","in","which","cells","interpret","a","specific","environment","."),4044883). assertion_content_comment('tOboGo_NeuralPlateThickening',s("The","process","of","apical-basal","elongation","of","individual","ectodermal","cells","during","the","formation","of","the","neural","placode","."),4046470). assertion_content_comment('tOboGo_NeuralPrecursorCellProliferation',s("The","multiplication","or","reproduction","of","neural","precursor","cells",",","resulting","in","the","expansion","of","a","cell","population",".","A","neural","precursor","cell","is","either","a","nervous","system","stem","cell","or","a","nervous","system","progenitor","cell","."),3990286). assertion_content_comment('tOboGo_NeuralRetinaDevelopment',s("The","progression","of","the","neural","retina","over","time","from","its","initial","formation","to","the","mature","structure",".","The","neural","retina","is","the","part","of","the","retina","that","contains","neurons","and","photoreceptor","cells","."),4004651). assertion_content_comment('tOboGo_NeuralRodCavitation',s("The","process","of","rod","cavitation",",","which","is","the","formation","of","a","lumen","in","the","neural","rod","during","primary","neurulation",",","producing","the","neural","tube","."),4039245). assertion_content_comment('tOboGo_NeuralRodFormation',s("The","formation","of","a","solid","rod","of","neurectoderm","derived","from","the","neural","keel",".","The","neural","rod","is","roughly","circular","in","cross","section",".","Neural","rod","formation","occurs","during","primary","neurulation","in","teleosts","."),4039255). assertion_content_comment('tOboGo_NeuralTubeClosure',s("The","last","step","in","the","formation","of","the","neural","tube",",","where","the","paired","neural","folds","are","brought","together","and","fuse","at","the","dorsal","midline","."),3987208). assertion_content_comment('tOboGo_NeuralTubeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","neural","tube","over","time",",","from","its","formation","to","the","mature","structure",".","The","mature","structure","of","the","neural","tube","exists","when","the","tube","has","been","segmented","into","the","forebrain",",","midbrain",",","hindbrain","and","spinal","cord","regions",".","In","addition","neural","crest","has","budded","away","from","the","epithelium","."),3987141). assertion_content_comment('tOboGo_NeuralTubeFormation',s("The","formation","of","a","tube","from","the","flat","layer","of","ectodermal","cells","known","as","the","neural","plate",".","This","will","give","rise","to","the","central","nervous","system","."),3987152). assertion_content_comment('tOboGo_NeuralTubePatterning',s("The","regionalization","process","that","regulates","the","coordinated","growth","that","establishes","the","non-random","spatial","arrangement","of","the","neural","tube","."),4041254). assertion_content_comment('tOboGo_NeurexinBinding',s("Interacting","selectively","and","non-covalently","with","neurexins",",","synaptic","cell","surface","proteins","related","to","latrotoxin","receptor",",","laminin","and","agrin",".","Neurexins","act","as","cell","recognition","molecules","at","nerve","terminals","."),4217072). assertion_content_comment('tOboGo_NeuroblastActivation',s("A","change","in","the","morphology","or","behavior","of","a","neuroblast","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand","."),4019599). assertion_content_comment('tOboGo_NeuroblastDelamination',s("The","negative","regulation","of","cell","adhesion","process","in","which","a","neuroblast","slits","off","of","a","neurectodermal","sheet","."),4160066). assertion_content_comment('tOboGo_NeuroblastDevelopment',s("The","process","aimed","at","the","progression","of","a","neuroblast","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","state",",","to","the","mature","neuroblast",".","It","does","not","include","processes","where","the","neuroblast","turns","into","a","glial","cell","or","a","neuron","."),4039200). assertion_content_comment('tOboGo_NeuroblastDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuroblast",".","There","are","at","least","four","stages","through","which","the","pluripotent","cells","of","epiblast","or","blastula","become","neuroblasts","."),4019679). assertion_content_comment('tOboGo_NeuroblastDivisionInDorsalLateralGanglionicEminence',s("The","division","of","neuroblasts","in","the","dorsal","region","of","the","lateral","ganglionic","eminence",".","These","cells","give","rise","to","embryonic","interneuron","precursors","that","will","migrate","tangentially","to","the","olfactory","bulb","."),4050981). assertion_content_comment('tOboGo_NeuroblastDivisionInPallium',s("The","division","of","neuroblasts","in","the","pallium",".","Neuroblasts","are","precursor","cells","that","give","rise","to","neurons","."),4053495). assertion_content_comment('tOboGo_NeuroblastDivisionInSubpallium',s("The","division","of","neuroblasts","in","the","subpallium","area","of","the","forebrain",".","The","interneuron","precursors","that","these","cells","give","rise","to","include","GABAergic","interneurons","and","will","migrate","tangentially","."),4050882). assertion_content_comment('tOboGo_NeuroblastDivisionInSubventricularZone',s("The","division","of","neuroblasts","in","the","subventricular","zone","of","the","forebrain",".","The","interneuron","precursors","that","these","cells","give","rise","to","include","adult","olfactory","bulb","interneurons","and","migrate","tangentially","."),4050836). assertion_content_comment('tOboGo_NeuroblastDivision',s("The","process","resulting","in","the","physical","partitioning","and","separation","of","a","neuroblast","into","daughter","cells",".","A","neuroblast","is","any","cell","that","will","divide","and","give","rise","to","a","neuron","."),4047352). assertion_content_comment('tOboGo_NeuroblastFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","differentiate","into","a","neuroblast","."),4019681). assertion_content_comment('tOboGo_NeuroblastFateDetermination',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","neuroblast","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed",".","An","example","of","this","process","is","found","in","Mus","musculus","."),4019694). assertion_content_comment('tOboGo_NeuroblastFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","neuroblast","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",".","Upon","specification",",","the","cell","fate","can","be","reversed","."),4039190). assertion_content_comment('tOboGo_NeuroblastProliferation',s("The","expansion","of","a","neuroblast","population","by","cell","division",".","A","neuroblast","is","any","cell","that","will","divide","and","give","rise","to","a","neuron","."),3990289). assertion_content_comment('tOboGo_NeuroendocrineCellDifferentiationInvolvedInProstateGlandAcinusDevelopment',s("The","process","in","which","relatively","unspecialized","cells","acquires","specialized","structural","and","functions","of","a","neuroendocrine","cell","of","the","prostate","gland","acinus","."),4116347). assertion_content_comment('tOboGo_NeuroendocrineCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","structural","and/or","functional","features","of","a","neuroendocrine","cell",".","A","neuroendocrine","cell","is","a","cell","that","receives","input","form","a","neuron","which","controls","the","secretion","of","an","endocrine","substance","."),4116344). assertion_content_comment('tOboGo_NeuroepithelialCellDifferentiation',s("The","process","in","which","epiblast","cells","acquire","specialized","features","of","neuroepithelial","cells","."),3989709). assertion_content_comment('tOboGo_NeurofilamentBundleAssembly',s("The","assembly","of","neurofilaments","into","bundles",",","in","which","the","filaments","are","longitudinally","oriented",",","with","numerous","crossbridges","between","them",".","Neurofilament","bundles","may","be","cross-linked","to","each","other",",","to","membrane-bounded","organelles","or","other","cytoskeletal","structures","such","as","microtubules","."),4341747). assertion_content_comment('tOboGo_NeurofilamentCytoskeletonOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","neurofilaments","and","their","associated","proteins","."),4159266). assertion_content_comment('tOboGo_NeurofilamentCytoskeleton',s("Intermediate","filament","cytoskeletal","structure","that","is","made","up","of","neurofilaments",".","Neurofilaments","are","specialized","intermediate","filaments","found","in","neurons","."),4008417). assertion_content_comment('tOboGo_Neurofilament',s("A","type","of","intermediate","filament","found","in","the","core","of","neuronal","axons",".","Neurofilaments","are","heteropolymers","composed","of","three","type","IV","polypeptides",":","NF-L",",","NF-M",",","and","NF-H","(","for","low",",","middle",",","and","high","molecular","weight",")","Neurofilaments","are","responsible","for","the","radial","growth","of","an","axon","and","determine","axonal","diameter","."),4008461). assertion_content_comment('tOboGo_Neurogenesis',s("Generation","of","cells","within","the","nervous","system","."),3984945). assertion_content_comment('tOboGo_NeurohypophysealHormoneActivity',s("The","action","characteristic","of","a","neurohypophyseal","hormone",",","any","of","a","family","of","structurally","and","functionally","related","nonapeptides","that","are","synthesized","as","part","of","a","larger","precursor","molecule","comprising","a","signal","peptide",",","the","nonapeptide","hormone",",","and","a","neurophysin","."),4216913). assertion_content_comment('tOboGo_NeurohypophysisDevelopment',s("The","progression","of","the","neurohypophysis","over","time","from","its","initial","formation","until","its","mature","state",".","The","neurohypophysis","is","the","part","of","the","pituitary","gland","that","secretes","hormones","involved","in","blood","pressure","regulation","."),4046410). assertion_content_comment('tOboGo_NeurohypophysisFormation',s("The","process","that","gives","rise","to","neurohypophysis",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","neurohypophysis","is","the","part","of","the","pituitary","gland","that","secretes","hormones","involved","in","blood","pressure","regulation","."),4105695). assertion_content_comment('tOboGo_NeurohypophysisMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","neurohypophysis","are","generated","and","organized",".","The","neurohypophysis","is","the","part","of","the","pituitary","gland","that","secretes","hormones","involved","in","blood","pressure","regulation","."),4105682). assertion_content_comment('tOboGo_NeurokininReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neurokinin","receptor","."),4324312). assertion_content_comment('tOboGo_Neuroligin',s("OBSOLETE",".","A","class","of","ligands","for","neurexins","."),4217076). assertion_content_comment('tOboGo_NeurologicalSystemProcessInvolvedInRegulationOfSystemicArterialBloodPressure',s("The","regulation","of","blood","pressure","mediated","by","detection","of","stimuli","and","a","neurological","response","."),3987269). assertion_content_comment('tOboGo_NeurologicalSystemProcess',s("A","organ","system","process","carried","out","by","any","of","the","organs","or","tissues","of","neurological","system","."),3981386). assertion_content_comment('tOboGo_NeuromastDeposition',s("The","process","in","which","a","migrating","neuromast","primordium","deposits","clusters","of","undifferentiated","cells","(","proneuromasts",")","along","its","migratory","path","in","a","developing","lateral","line","."),4105718). assertion_content_comment('tOboGo_NeuromastDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","neuromast","over","time",",","from","its","formation","to","the","mature","structure",".","The","neuromast","is","the","sensory","organ","of","the","lateral","line","and","is","composed","of","a","population","of","sensory","hair","cells",",","and","nonsensory","supporting","cells","and","mantle","cells",".","Neuromasts","are","located","superficially","on","the","epithelium","or","in","lateral","line","canals","."),4082610). assertion_content_comment('tOboGo_NeuromastHairCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","neuromast","hair","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","neuromast","hair","cell","is","a","hair","cell","that","acts","as","a","sensory","receptor","of","the","neuromast",";","it","is","morphologically","polarized","as","a","result","of","the","relative","position","of","the","single","kinocilium","and","the","clusters","of","stereocilia","on","its","apical","surface",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","specific","fate","."),4082614). assertion_content_comment('tOboGo_NeuromastHairCellDifferentiationInvolvedInNeuromastRegeneration',s("Differentiation","of","new","neuromast","sensory","hair","cells","to","replace","those","lost","or","destroyed","by","injury","."),4130536). assertion_content_comment('tOboGo_NeuromastHairCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuromast","hair","cell",".","Hair","cells","are","the","sensory","receptors","of","the","neuromast","and","are","located","in","a","portion","of","the","neuromast","called","the","sensory","strip",".","Each","hair","cell","of","the","neuromast","is","morphologically","polarized","as","a","result","of","the","relative","position","of","the","single","kinocilium","and","the","clusters","of","stereocilia","on","its","apical","surface",".","There","are","approximately","seven","hair","cells","within","each","neuromast",",","with","each","hair","cell","innervated","by","afferent","and","efferent","neurons","."),4082612). assertion_content_comment('tOboGo_NeuromastHairCellMorphogenesis',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","when","a","neuromast","hair","cell","progresses","from","its","initial","formation","to","its","mature","state",".","A","neuromast","hair","cell","is","a","hair","cell","that","acts","as","a","sensory","receptor","of","the","neuromast",";","it","is","morphologically","polarized","as","a","result","of","the","relative","position","of","the","single","kinocilium","and","the","clusters","of","stereocilia","on","its","apical","surface","."),4082624). assertion_content_comment('tOboGo_NeuromastMantleCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuromast","mantle","cell",".","Mantle","cells","are","non-sensory","cells","that","surround","the","sensory","strip",",","separating","the","neuromast","from","the","epidermis",".","Mantle","cells","secrete","the","cupula","in","which","the","ciliary","bundles","of","all","of","the","hair","cells","are","embedded","."),4105821). assertion_content_comment('tOboGo_NeuromastPrimordiumMigration',s("The","migration","of","a","cluster","of","a","relatively","undifferentiated","cell","originating","at","specific","cephalic","placodes","and","depositing","proneuromasts","along","a","developing","lateral","line",",","from","which","the","neuromasts","will","develop","."),4105738). assertion_content_comment('tOboGo_NeuromastRegeneration',s("The","regrowth","of","a","neuromast","following","its","loss","or","destruction","."),4130525). assertion_content_comment('tOboGo_NeuromastSupportCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuromast","support","cell",".","Support","cells","are","non-sensory","cells","of","the","neuromast","that","extend","between","the","sensory","hair","cells","from","the","basement","membrane","to","the","apical","surface",";","they","are","surrounded","by","mantle","cells","."),4105759). assertion_content_comment('tOboGo_NeuromedinBReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neuromedin","B","receptor","."),4323208). assertion_content_comment('tOboGo_NeuromedinKReceptorActivity',s("Combining","with","neuromedin","K",",","the","peptide","Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met","to","initiate","a","change","in","cell","activity","."),4305004). assertion_content_comment('tOboGo_NeuromedinKReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neuromedin","K","receptor","."),4324315). assertion_content_comment('tOboGo_NeuromedinUBinding',s("Interacting","selectively","and","non-covalently","and","stoichiometrically","with","neuromedin","U",",","a","hypothalamic","peptide","involved","in","energy","homeostasis","and","stress","responses","."),4315757). assertion_content_comment('tOboGo_NeuromedinUReceptorActivity',s("Combining","with","neuromedin","U","to","initiate","a","change","in","cell","activity","."),4383542). assertion_content_comment('tOboGo_NeuromedinUReceptorBinding',s("Interacting","selectively","and","non-covalently","with","one","or","more","specific","sites","on","a","neuromedin","U","receptor","."),4315777). assertion_content_comment('tOboGo_NeuromuscularJunctionDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","neuromuscular","junction","over","time",",","from","its","formation","to","the","mature","structure","."),4018520). assertion_content_comment('tOboGo_NeuromuscularJunction',s("The","junction","between","the","axon","of","a","motor","neuron","and","a","muscle","fiber",".","In","response","to","the","arrival","of","action","potentials",",","the","presynaptic","button","releases","molecules","of","neurotransmitters","into","the","synaptic","cleft",".","These","diffuse","across","the","cleft","and","transmit","the","signal","to","the","postsynaptic","membrane","of","the","muscle","fiber",",","leading","to","a","post-synaptic","potential","responsible","of","the","muscle","contraction","."),4322175). assertion_content_comment('tOboGo_NeuromuscularProcessControllingBalance',s("Any","process","that","an","organism","uses","to","control","its","balance",",","the","orientation","of","the","organism","(","or","the","head","of","the","organism",")","in","relation","to","the","source","of","gravity",".","In","humans","and","animals",",","balance","is","perceived","through","visual","cues",",","the","labyrinth","system","of","the","inner","ears","and","information","from","skin","pressure","receptors","and","muscle","and","joint","receptors","."),4100543). assertion_content_comment('tOboGo_NeuromuscularProcessControllingPosture',s("Any","process","in","which","an","organism","voluntarily","modulates","its","posture",",","the","alignment","of","its","anatomical","parts","."),4045045). assertion_content_comment('tOboGo_NeuromuscularProcess',s("Any","process","pertaining","to","the","functions","of","the","nervous","and","muscular","systems","of","an","organism","."),4045041). assertion_content_comment('tOboGo_NeuromuscularSynapticTransmission',s("The","process","of","communication","from","a","neuron","to","a","muscle",",","across","a","synapse","."),4108648). assertion_content_comment('tOboGo_NeuronalActionPotentialPropagation',s("A","neurological","process","that","causes","the","sequential","depolarization","of","a","neuron","'","s","cell","membrane","along","an","axon","."),4045025). assertion_content_comment('tOboGo_NeuronalCellBodyMembrane',s("The","plasma","membrane","of","a","neuron","cell","body","-","excludes","the","plasma","membrane","of","cell","projections","such","as","axons","and","dendrites","."),4070340). assertion_content_comment('tOboGo_NeuronalCellBody',s("The","portion","of","a","neuron","that","includes","the","nucleus",",","but","excludes","all","cell","projections","such","as","axons","and","dendrites","."),4070317). assertion_content_comment('tOboGo_NeuronalIonChannelClustering',s("The","process","in","which","voltage-gated","ion","channels","become","localized","to","distinct","subcellular","domains","in","the","neuron",".","Specific","targeting",",","clustering",",","and","maintenance","of","these","channels","in","their","respective","domains","are","essential","to","achieve","high","conduction","velocities","of","action","potential","propagation","."),4086686). assertion_content_comment('tOboGo_NeuronalPentraxinReceptorActivity',s("Combining","with","a","neuronal","pentraxin","to","initiate","a","change","in","cell","activity","."),4246929). assertion_content_comment('tOboGo_NeuronalRNAGranule',s("A","ribonucleoprotein","complex","that","is","found","in","the","cytoplasm","of","axons","and","dendrites",",","and","transports","translationally","silenced","mRNAs","to","dendritic","synapses",",","where","they","are","released","and","translated","in","response","to","specific","exogenous","stimuli","."),4129904). assertion_content_comment('tOboGo_NeuronalSignalTransduction',s("The","process","in","which","an","activated","neuronal","cell","receptor","conveys","information","down","a","signaling","pathway",",","resulting","in","a","change","in","the","function","or","state","of","a","cell",".","This","process","may","be","intracellular","or","intercellular","."),4347107). assertion_content_comment('tOboGo_NeuronApoptosis',s("The","process","of","apoptosis","in","neurons",",","the","basic","cellular","unit","of","nervous","tissue",".","Each","neuron","consists","of","a","body",",","an","axon",",","and","dendrites",".","Their","purpose","is","to","receive",",","conduct",",","and","transmit","impulses","in","the","nervous","system","."),4064485). assertion_content_comment('tOboGo_NeuronDeath',s("The","process","of","cell","death","in","a","neuron","."),4064481). assertion_content_comment('tOboGo_NeuronDevelopmentInvolvedInAmphidSensoryOrganDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","neuron","over","time",",","that","contributes","to","the","development","of","the","amphid","sensory","organ","."),4004744). assertion_content_comment('tOboGo_NeuronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","neuron","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell","."),3992752). assertion_content_comment('tOboGo_NeuronDifferentiationInvolvedInAmphidSensoryOrganDevelopment',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuron","that","contributes","to","the","progression","of","the","amphid","sensory","gland","."),4004742). assertion_content_comment('tOboGo_NeuronDifferentiationInvolvedInSalivaryGlandDevelopment',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","structural","and/or","functional","features","that","characterize","the","neurons","of","the","salivary","gland","."),4161223). assertion_content_comment('tOboGo_NeuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuron","."),3984952). assertion_content_comment('tOboGo_NeuronFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","neuron","."),3985247). assertion_content_comment('tOboGo_NeuronFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","neuron","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4077941). assertion_content_comment('tOboGo_NeuronFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","neuron","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",".","Upon","specification",",","the","cell","fate","can","be","reversed","."),4033422). assertion_content_comment('tOboGo_NeuronHomeostasis',s("The","cellular","homeostatic","process","that","preserves","a","neuron","in","a","stable",",","differentiated","functional","and","structural","state","."),4180652). assertion_content_comment('tOboGo_NeuronMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","neuron","to","attain","its","fully","functional","state","."),4039109). assertion_content_comment('tOboGo_NeuronMigrationInvolvedInAmphidSensoryOrganDendriteRetrogradeExtension',s("The","directed",",","self-propelled","movement","of","a","neuron","that","contributes","to","the","process","of","retrograde","extension","of","a","dendrite","of","a","neuron","in","the","amphid","sensory","organ","."),4004776). assertion_content_comment('tOboGo_NeuronMigrationInvolvedInDendriteRetrogradeExtension',s("The","directed",",","self-propelled","movement","of","a","neuron","that","contributes","to","the","process","of","retrograde","extension","of","a","dendrite","."),4004773). assertion_content_comment('tOboGo_NeuronMigrationInvolvedInRetrogradeExtension',s("The","directed",",","self-propelled","movement","of","a","neuron","that","contributes","to","the","process","of","retrograde","extension","."),4004770). assertion_content_comment('tOboGo_NeuronMigration',s("The","characteristic","movement","of","an","immature","neuron","from","germinal","zones","to","specific","positions","where","they","will","reside","as","they","mature","."),3985369). assertion_content_comment('tOboGo_NeuronProjectionDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","neuron","projection","over","time",",","from","its","formation","to","the","mature","structure",".","A","neuron","projection","is","any","process","extending","from","a","neural","cell",",","such","as","axons","or","dendrites","(","collectively","called","neurites",")"),4004693). assertion_content_comment('tOboGo_NeuronProjectionMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","neuron","projection","."),4051618). assertion_content_comment('tOboGo_NeuronProjectionMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","neuron","projection","are","generated","and","organized",".","A","neuron","projection","is","any","process","extending","from","a","neural","cell",",","such","as","axons","or","dendrites","."),4017236). assertion_content_comment('tOboGo_NeuronProjectionRegeneration',s("The","regrowth","of","neuronal","processes","such","as","axons","or","dendrites","in","response","to","their","loss","or","damage","."),4036306). assertion_content_comment('tOboGo_NeuronProjection',s("A","prolongation","or","process","extending","from","a","nerve","cell",",","e.g",".","an","axon","or","dendrite","."),4008450). assertion_content_comment('tOboGo_NeuronProjectionTerminus',s("The","specialized",",","terminal","region","of","a","neuron","projection","such","as","an","axon","or","a","dendrite","."),4093166). assertion_content_comment('tOboGo_NeuronRecognition',s("The","process","in","which","a","neuronal","cell","in","a","multicellular","organism","interprets","its","surroundings","."),4015040). assertion_content_comment('tOboGo_NeuronRemodeling',s("The","developmentally","regulated","remodeling","of","neuronal","projections","such","as","pruning","to","eliminate","the","extra","dendrites","and","axons","projections","set","up","in","early","stages","of","nervous","system","development","."),4304326). assertion_content_comment('tOboGo_NeuronSpine',s("A","small","membranous","protrusion",",","often","ending","in","a","bulbous","head","and","attached","to","the","neuron","by","a","narrow","stalk","or","neck","."),4067487). assertion_content_comment('tOboGo_NeuropeptideBinding',s("Interacting","selectively","and","non-covalently","and","stoichiometrically","with","neuropeptides",",","peptides","with","direct","synaptic","effects","(","peptide","neurotransmitters",")","or","indirect","modulatory","effects","on","the","nervous","system","(","peptide","neuromodulators",")"),4197736). assertion_content_comment('tOboGo_NeuropeptideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","neuropeptides",".","Neuropeptides","are","signaling","peptides","that","travel","across","a","synaptic","junction","."),4335909). assertion_content_comment('tOboGo_NeuropeptideFReceptorActivity',s("Combining","with","neuropeptide","F",",","an","invertebrate","neuropeptide","thought","to","play","a","role","in","neuroregulation",",","to","initiate","a","change","in","cell","activity",".","In","many","species",",","neuropeptide","F","is","between","36","and","39","amino","acid","residues","terminating","in","a","phenylalaninamide","residue","."),4314584). assertion_content_comment('tOboGo_NeuropeptideFReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neuropeptide","F","receptor","."),4170956). assertion_content_comment('tOboGo_NeuropeptideHormoneActivity',s("The","action","characteristic","of","a","neuropeptide","hormone",",","any","peptide","hormone","that","acts","in","the","central","nervous","system",".","A","neuropeptide","is","any","of","several","types","of","molecules","found","in","brain","tissue",",","composed","of","short","chains","of","amino","acids",";","they","include","endorphins",",","enkephalins",",","vasopressin",",","and","others",".","They","are","often","localized","in","axon","terminals","at","synapses","and","are","classified","as","putative","neurotransmitters",",","although","some","are","also","hormones","."),4216910). assertion_content_comment('tOboGo_NeuropeptideReceptorActivity',s("Combining","with","a","neuropeptide","to","initiate","a","change","in","cell","activity","."),4197738). assertion_content_comment('tOboGo_NeuropeptideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neuropeptide","receptor","."),4170590). assertion_content_comment('tOboGo_NeuropeptideSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","peptide","neurotransmitter","binding","to","a","cell","surface","receptor","."),4235685). assertion_content_comment('tOboGo_NeuropeptideYReceptorActivity',s("Combining","with","neuropeptide","Y","to","initiate","a","change","in","cell","activity","."),4198904). assertion_content_comment('tOboGo_NeuropeptideYReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neuropeptide","Y","receptor","."),4324001). assertion_content_comment('tOboGo_NeuroporeClosure',s("The","process","of","joining","together","the","neural","folds","at","either","end","of","the","neural","tube","."),4041500). assertion_content_comment('tOboGo_Neuroprotection',s("Any","process","that","modulates","the","occurrence","or","rate","of","cell","death","by","apoptosis","in","the","nervous","system",".","It","may","stop","or","prevent","or","reduce","the","rate","of","cell","death","by","apoptosis","and","it","is","activated","by","stress","to","counteract","death","signals","in","central","nervous","systems",".","Different","neuroprotective","mechanisms","may","be","activated","to","combat","distinct","types","of","cellular","stress",",","ERK","pathway","is","one","of","several","neuroprotective","mechanisms","and","it","is","a","model","system","to","study","neuronal","apoptosis",",","which","may","contribute","to","several","neurodegenerative","diseases","and","aging-related","neuron","loss","."),4325601). assertion_content_comment('tOboGo_NeurotensinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neurotensin","receptor","."),4324053). assertion_content_comment('tOboGo_NeurotoxinActivity',s("OBSOLETE",".","Acts","to","inhibit","neural","function","in","another","living","organism","."),4233652). assertion_content_comment('tOboGo_NeurotransmitterBinding',s("Interacting","selectively","and","non-covalently","with","a","neurotransmitter",",","any","chemical","substance","that","is","capable","of","transmitting","(","or","inhibiting","the","transmission","of",")","a","nerve","impulse","from","a","neuron","to","another","cell","."),4197724). assertion_content_comment('tOboGo_NeurotransmitterBiosyntheticProcessAndStorage',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","neurotransmitters","and","the","storage","of","the","synthesized","molecules","."),4361565). assertion_content_comment('tOboGo_NeurotransmitterBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","of","a","group","of","substances","that","are","released","on","excitation","from","the","axon","terminal","of","a","presynaptic","neuron","of","the","central","or","peripheral","nervous","system","and","travel","across","the","synaptic","cleft","to","either","excite","or","inhibit","the","target","cell","."),4231907). assertion_content_comment('tOboGo_NeurotransmitterCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","of","a","group","of","substances","that","are","released","on","excitation","from","the","axon","terminal","of","a","presynaptic","neuron","of","the","central","or","peripheral","nervous","system","and","travel","across","the","synaptic","cleft","to","either","excite","or","inhibit","the","target","cell","."),3981712). assertion_content_comment('tOboGo_NeurotransmitterMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","neurotransmitters",",","any","of","a","group","of","substances","that","are","released","on","excitation","from","the","axon","terminal","of","a","presynaptic","neuron","of","the","central","or","peripheral","nervous","system","and","travel","across","the","synaptic","cleft","to","either","excite","or","inhibit","the","target","cell","."),3981659). assertion_content_comment('tOboGo_NeurotransmitterReceptorActivity',s("Combining","with","a","neurotransmitter","to","initiate","a","change","in","cell","activity","."),4197726). assertion_content_comment('tOboGo_NeurotransmitterReceptorBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","neurotransmitter","receptors","."),4298987). assertion_content_comment('tOboGo_NeurotransmitterReceptorCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","neurotransmitter","receptors","."),4073865). assertion_content_comment('tOboGo_NeurotransmitterReceptorMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","neurotransmitter","receptors","."),4073862). assertion_content_comment('tOboGo_NeurotransmitterSecretionInvolvedInRegulationOfSkeletalMuscleContraction',s("The","regulated","release","of","neurotransmitter","into","the","synaptic","cleft","involved","in","skeletal","muscle","contraction",".","A","neurotransmitter","is","any","of","a","group","of","substances","that","are","released","on","excitation","from","the","axon","terminal","of","a","presynaptic","neuron","of","the","central","or","peripheral","nervous","system","and","travel","across","the","synaptic","cleft","to","either","excite","or","inhibit","the","target","cell",".","Among","the","many","substances","that","have","the","properties","of","a","neurotransmitter","are","acetylcholine",",","noradrenaline",",","adrenaline",",","dopamine",",","glycine",",","gamma","aminobutyrate",",","glutamic","acid",",","substance","P",",","enkephalins",",","endorphins","and","serotonin","."),4038704). assertion_content_comment('tOboGo_NeurotransmitterSecretion',s("The","regulated","release","of","neurotransmitter","into","the","synaptic","cleft",".","A","neurotransmitter","is","any","of","a","group","of","substances","that","are","released","on","excitation","from","the","axon","terminal","of","a","presynaptic","neuron","of","the","central","or","peripheral","nervous","system","and","travel","across","the","synaptic","cleft","to","either","excite","or","inhibit","the","target","cell",".","Among","the","many","substances","that","have","the","properties","of","a","neurotransmitter","are","acetylcholine",",","noradrenaline",",","adrenaline",",","dopamine",",","glycine",",","gamma-aminobutyrate",",","glutamic","acid",",","substance","P",",","enkephalins",",","endorphins","and","serotonin","."),3988073). assertion_content_comment('tOboGo_NeurotransmitterSecretoryPathway',s("A","regulated","secretory","pathway","in","which","neurotransmitters","are","initially","stored","in","secretory","vesicles","for","later","release","."),4027897). assertion_content_comment('tOboGo_NeurotransmitterSignalingInitiatingCellMovementInvolvedInCerebralCortexRadialGliaGuidedMigration',s("Signaling","by","neurotransmitters","and","their","receptors","that","results","in","the","initiation","of","movement","of","cells","as","a","component","of","the","process","of","glial-mediated","radial","migration","."),4049966). assertion_content_comment('tOboGo_Neurotransmitter_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","neurotransmitter","(","out",")","+","Na","+","(","out",")","=","neurotransmitter","(","in",")","+","Na","+","(","in",")"),4216206). assertion_content_comment('tOboGo_NeurotransmitterTransporterActivity',s("Enables","the","directed","movement","of","a","neurotransmitter","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Neurotransmitters","are","any","chemical","substance","that","is","capable","of","transmitting","(","or","inhibiting","the","transmission","of",")","a","nerve","impulse","from","a","neuron","to","another","cell","."),4215756). assertion_content_comment('tOboGo_NeurotransmitterTransport',s("The","directed","movement","of","a","neurotransmitter","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Neurotransmitters","are","any","chemical","substance","that","is","capable","of","transmitting","(","or","inhibiting","the","transmission","of",")","a","nerve","impulse","from","a","neuron","to","another","cell","."),3988026). assertion_content_comment('tOboGo_NeurotransmitterUptake',s("The","directed","movement","of","neurotransmitters","into","neurons","or","glial","cells",".","This","process","leads","to","inactivation","and","recycling","of","neurotransmitters",".","It","does","not","occur","during","cholinergic","synaptic","transmission",".","Instead",",","acetylcholine","is","enzymatically","degraded","in","the","synaptic","cleft","."),4120307). assertion_content_comment('tOboGo_NeurotrophicFactorSignalingInitiatingCellMovementInvolvedInCerebralCortexRadialGliaGuidedMigration',s("Signaling","between","members","of","the","neurotrophin","family","and","their","receptors","that","result","in","the","start","of","cell","motility","as","a","component","of","the","process","of","cerebral","cortex","glial-mediated","radial","migration","."),4050203). assertion_content_comment('tOboGo_NeurotrophinBinding',s("Interacting","selectively","and","non-covalently","with","neurotrophin",",","any","of","a","family","of","growth","factors","that","block","apoptosis","in","neurons","and","thus","promote","nerve","growth","."),4159760). assertion_content_comment('tOboGo_NeurotrophinP75ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","neurotrophin","p75","receptor","."),4217173). assertion_content_comment('tOboGo_NeurotrophinProduction',s("The","appearance","of","a","neurotrophin","due","to","biosynthesis","or","secretion","by","cells","in","a","neuron","'","s","target","field",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels",".","A","neurotrophin","is","any","of","a","family","of","growth","factors","that","block","apoptosis","in","neurons","and","thus","promote","nerve","growth","."),4064513). assertion_content_comment('tOboGo_NeurotrophinReceptorActivity',s("Combining","with","neurotrophin",",","any","of","a","family","of","growth","factors","that","block","apoptosis","in","neurons","and","thus","promote","nerve","growth",",","to","initiate","a","change","in","cell","activity","."),4159763). assertion_content_comment('tOboGo_NeurotrophinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neurotrophin","receptor","."),4217124). assertion_content_comment('tOboGo_NeurotrophinTRKAReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4214086). assertion_content_comment('tOboGo_NeurotrophinTRKAReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","neurotrophin","TRKA","receptor","."),4217163). assertion_content_comment('tOboGo_NeurotrophinTRKBReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4214157). assertion_content_comment('tOboGo_NeurotrophinTRKBReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","neurotrophin","TRKB","receptor","."),4217153). assertion_content_comment('tOboGo_NeurotrophinTRKCReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4214113). assertion_content_comment('tOboGo_NeurotrophinTRKCReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","neurotrophin","TRKC","receptor","."),4217131). assertion_content_comment('tOboGo_NeurotrophinTRKReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4214100). assertion_content_comment('tOboGo_NeurotrophinTRKReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","neurotrophin","TRK","receptor","."),4217128). assertion_content_comment('tOboGo_NeutralAminoAcidExportFromVacuole',s("The","directed","movement","of","neutral","amino","acids","out","of","the","vacuole","."),4357547). assertion_content_comment('tOboGo_NeutralAminoAcidImportIntoVacuole',s("The","directed","movement","of","neutral","amino","acids","into","the","vacuole","."),4357441). assertion_content_comment('tOboGo_NeutralAminoAcid_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","neutral","amino","acid","(","out",")","+","Na","+","(","out",")","=","neutral","amino","acid","(","in",")","+","Na","+","(","in",")"),4215841). assertion_content_comment('tOboGo_NeutralAminoAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","neutral","amino","acids","from","one","side","of","a","membrane","to","the","other",".","Neutral","amino","acids","have","a","pH","of","7","."),4215825). assertion_content_comment('tOboGo_NeutralAminoAcidTransport',s("The","directed","movement","of","neutral","amino","acids",",","amino","acids","with","no","net","charge",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4115127). assertion_content_comment('tOboGo_NeutralCationicAminoAcid_Sodium_ChlorideSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","neutral/cationic","amino","acid","(","out",")","+","Na","+","(","out",")","+","Cl-","(","out",")","=","neutral/cationic","amino","acid","(","in",")","+","Na","+","(","in",")","+","Cl-","(","in",")"),4295835). assertion_content_comment('tOboGo_NeutralLipidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","neutral","lipids",",","lipids","only","soluble","in","solvents","of","very","low","polarity","."),4036980). assertion_content_comment('tOboGo_NeutralLipidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","neutral","lipids",",","lipids","only","soluble","in","solvents","of","very","low","polarity","."),4037678). assertion_content_comment('tOboGo_NeutralLipidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","neutral","lipids",",","lipids","only","soluble","in","solvents","of","very","low","polarity","."),4036921). assertion_content_comment('tOboGo_NeutrophilActivationInvolvedInImmuneResponse',s("The","change","in","morphology","and","behavior","of","a","neutrophil","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4093569). assertion_content_comment('tOboGo_NeutrophilActivation',s("The","change","in","morphology","and","behavior","of","a","neutrophil","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),4093567). assertion_content_comment('tOboGo_NeutrophilAggregation',s("The","adhesion","of","one","neutrophil","to","one","or","more","other","neutrophils","via","adhesion","molecules","."),4141708). assertion_content_comment('tOboGo_NeutrophilApoptosis',s("The","process","of","apoptosis","in","neutrophils","."),3984736). assertion_content_comment('tOboGo_NeutrophilChemotaxis',s("The","directed","movement","of","a","neutrophil","cell",",","the","most","numerous","polymorphonuclear","leukocyte","found","in","the","blood",",","in","response","to","an","external","stimulus",",","usually","an","infection","or","wounding","."),4149795). assertion_content_comment('tOboGo_NeutrophilCollagenaseActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","interstitial","collagens","in","the","triple","helical","domain",".","Unlike","EC",":","3.4.24.7",",","this","enzyme","cleaves","type","III","collagen","more","slowly","than","type","I","."),4246591). assertion_content_comment('tOboGo_NeutrophilDegranulation',s("The","regulated","exocytosis","of","secretory","granules","containing","preformed","mediators","such","as","proteases",",","lipases",",","and","inflammatory","mediators","by","a","neutrophil","."),4093584). assertion_content_comment('tOboGo_NeutrophilDifferentiation',s("The","process","in","which","a","myeloid","precursor","cell","acquires","the","specialized","features","of","a","neutrophil","."),4087282). assertion_content_comment('tOboGo_NeutrophilExtravasation',s("The","migration","of","a","neutrophil","from","the","blood","vessels","into","the","surrounding","tissue","."),4142563). assertion_content_comment('tOboGo_NeutrophilHomeostasis',s("The","process","of","regulating","the","proliferation","and","elimination","of","neutrophils","such","that","the","total","number","of","neutrophils","within","a","whole","or","part","of","an","organism","is","stable","over","time","in","the","absence","of","an","outside","stimulus","."),3984716). assertion_content_comment('tOboGo_NeutrophilMediatedCytotoxicity',s("The","directed","killing","of","a","target","cell","by","a","neutrophil","."),4131591). assertion_content_comment('tOboGo_NeutrophilMediatedImmunity',s("Any","process","involved","in","the","carrying","out","of","an","immune","response","by","a","neutrophil","."),4093582). assertion_content_comment('tOboGo_NeutrophilMediatedKillingOfBacterium',s("The","directed","killing","of","a","bacterium","by","a","neutrophil","."),4131597). assertion_content_comment('tOboGo_NeutrophilMediatedKillingOfFungus',s("The","directed","killing","of","a","fungal","cell","by","a","neutrophil","."),4131765). assertion_content_comment('tOboGo_NeutrophilMediatedKillingOfSymbiontCell',s("The","directed","killing","of","a","symbiont","target","cell","by","a","neutrophil","."),4131594). assertion_content_comment('tOboGo_NexinComplex',s("A","protein","complex","found","in","the","axoneme","of","eukaryotic","cilia","and","flagella",".","It","forms","interconnections","between","the","microtubule","outer","doublets","that","surround","the","inner","central","pair","of","microtubules","."),4220644). assertion_content_comment('tOboGo_Nexine',s("The","inner",",","non-sculptured","part","of","the","exine","which","lies","below","the","sexine","."),4095043). assertion_content_comment('tOboGo_NFAT1ProteinBinding',s("Interacting","selectively","and","non-covalently","with","NFAT1","(","nuclear","factor","of","activated","T","cells","1","protein",")",",","a","calcium-regulated","protein","which","acts","as","a","transcription","factor","."),4283544). assertion_content_comment('tOboGo_NFAT2ProteinBinding',s("Interacting","selectively","and","non-covalently","with","NFAT2","(","nuclear","factor","of","activated","T","cells","2","protein",")",",","a","calcium-regulated","protein","which","acts","as","a","transcription","factor","."),4283555). assertion_content_comment('tOboGo_NFAT3ProteinBinding',s("Interacting","selectively","and","non-covalently","with","NFAT3","(","nuclear","factor","of","activated","T","cells","3","protein",")",",","a","calcium-regulated","protein","which","acts","as","a","transcription","factor","."),4283575). assertion_content_comment('tOboGo_NFAT4ProteinBinding',s("Interacting","selectively","and","non-covalently","with","NFAT4","(","nuclear","factor","of","activated","T","cells","4","protein",")",",","a","calcium-regulated","protein","which","acts","as","a","transcription","factor","."),4283585). assertion_content_comment('tOboGo_NFAT5ProteinBinding',s("Interacting","selectively","and","non-covalently","with","NFAT1","(","nuclear","factor","of","activated","T","cells","1","protein",")",",","a","member","of","the","NFAT","transcription","factor","family","which","is","not","calcium","regulated","."),4283498). assertion_content_comment('tOboGo_NFATProteinBinding',s("Interacting","selectively","and","non-covalently","with","NFAT","(","nuclear","factor","of","activated","T","cells",")","proteins",",","a","family","of","transcription","factors",".","NFAT","proteins","have","crucial","roles","in","the","development","and","function","of","the","immune","system","."),4283494). assertion_content_comment('tOboGo_NFATProteinImportIntoNucleus',s("The","directed","movement","of","NFAT","(","nuclear","factor","of","activated","T","cells",")","proteins",",","a","family","of","transcription","factors",",","from","the","cytoplasm","into","the","nucleus",".","NFAT","proteins","are","dephosphorylated","in","the","cytoplasm","by","activated","calcineurin",",","which","leads","to","their","translocation","across","the","nuclear","membrane","."),4118585). assertion_content_comment('tOboGo_NHE3E3KARPACTN4Complex',s("A","heterotrimeric","protein","complex","formed","by","the","association","of","NHE3",",","E3KARP","and","alpha-actinin","upon","an","increase","in","calcium","ion","concentration",";","found","in","clusters","localized","on","plasma","membrane","and","in","intracellular","compartments","."),4337481). assertion_content_comment('tOboGo_Nic96Complex',s("A","protein","complex","that","forms","part","of","the","nuclear","pore","complex",",","and","is","required","for","its","correct","assembly",".","In","Saccharomyces","cerevisiae","Nic96","contains","Nsp1p",",","Nup57p",",","Nup49p",",","and","Nic96p","."),4109445). assertion_content_comment('tOboGo_NickelIonBinding',s("Interacting","selectively","and","non-covalently","with","nickel","(","Ni",")","ions","."),4303254). assertion_content_comment('tOboGo_NickelIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","nickel","ions","within","an","organism","or","cell","."),4381112). assertion_content_comment('tOboGo_NickelIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nickel","(","Ni",")","ions","from","one","side","of","a","membrane","to","the","other","."),4252840). assertion_content_comment('tOboGo_NickelIonTransmembraneTransport',s("The","directed","movement","of","nickel","(","Ni",")","ions","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4375689). assertion_content_comment('tOboGo_NickelIonTransport',s("The","directed","movement","of","nickel","(","Ni",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4289958). assertion_content_comment('tOboGo_NicotianamineAminotransferaseActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","nicotianamine","=","3","'","'","-deamino-3","'","'","-oxonicotianamine","+","L-glutamate","."),4343756). assertion_content_comment('tOboGo_NicotianamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotianamine",",","2","(","S",")",",","3","'","2","(","S",")",",","3","'","'","(","S",")","-N-","(","N-","(","3-amino-3-carboxypropyl",")","-3-amino-3-carboxypropyl",")","-azetidine-2-carboxylic","acid","."),4309950). assertion_content_comment('tOboGo_NicotianamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nicotianamine",",","2","(","S",")",",","3","'","2","(","S",")",",","3","'","'","(","S",")","-N-","(","N-","(","3-amino-3-carboxypropyl",")","-3-amino-3-carboxypropyl",")","-azetidine-2-carboxylic","acid","."),4309910). assertion_content_comment('tOboGo_NicotianamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotianamine",",","2","(","S",")",",","3","'","2","(","S",")",",","3","'","'","(","S",")","-N-","(","N-","(","3-amino-3-carboxypropyl",")","-3-amino-3-carboxypropyl",")","-azetidine-2-carboxylic","acid","."),4309904). assertion_content_comment('tOboGo_NicotianamineSynthaseActivity',s("Catalysis","of","the","reaction",":","3","S-adenosyl-L-methionine","(","1","+",")","=","3","S-methyl-5","'","-thioadenosine","+","3","H","(","+",")","+","nicotianamine","."),4310113). assertion_content_comment('tOboGo_NicotinamidaseActivity',s("Catalysis","of","the","reaction",":","nicotinamide","+","H2O","=","nicotinate","+","NH3","."),4248815). assertion_content_comment('tOboGo_NicotinamideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotinamide",",","pyridine-3-carboxamide",",","the","amide","of","nicotinic","acid",".","It","is","a","member","of","the","B","complex","of","vitamins","and","occurs","widely","in","living","organisms","."),4229968). assertion_content_comment('tOboGo_NicotinamideMononucleotideTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","nicotinamide","mononucleotide","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Nicotinamide","mononucleotide","is","a","ribonucleotide","in","which","the","nitrogenous","base",",","nicotinamide",",","is","in","beta-n-glycosidic","linkage","with","the","c-1","position","of","d-ribose",".","It","is","a","constituent","of","NAD","and","NADP","."),4290317). assertion_content_comment('tOboGo_NicotinamideMononucleotideTransmembraneTransport',s("The","process","in","which","nicotinamide","mononucleotide","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Nicotinamide","mononucleotide","is","a","ribonucleotide","in","which","the","nitrogenous","base",",","nicotinamide",",","is","in","beta-n-glycosidic","linkage","with","the","c-1","position","of","d-ribose",".","It","is","a","constituent","of","NAD","and","NADP","."),4383112). assertion_content_comment('tOboGo_NicotinamideMononucleotideTransport',s("The","directed","movement","of","nicotinamide","mononucleotide","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Nicotinamide","mononucleotide","is","a","ribonucleotide","in","which","the","nitrogenous","base",",","nicotinamide",",","is","in","beta-n-glycosidic","linkage","with","the","c-1","position","of","D-ribose",".","It","is","a","constituent","of","NAD","and","NADP","."),4294207). assertion_content_comment('tOboGo_NicotinamideNucleotideBiosyntheticProcessFromAspartate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","nucleotide","from","other","compounds",",","including","aspartate","."),4239552). assertion_content_comment('tOboGo_NicotinamideNucleotideBiosyntheticProcessFromNiacinamide',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","nucleotide","from","other","compounds",",","including","niacinamide","."),4239457). assertion_content_comment('tOboGo_NicotinamideNucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","nucleotides",",","any","nucleotide","that","contains","combined","nicotinamide","."),4229208). assertion_content_comment('tOboGo_NicotinamideNucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotinamide","nucleotides",",","any","nucleotide","that","contains","combined","nicotinamide","."),4021160). assertion_content_comment('tOboGo_NicotinamidePhosphoribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","diphosphate","+","nicotinamide","mononucleotide","=","5-phospho-alpha-D-ribose","1-diphosphate","+","H","(","+",")","+","nicotinamide","."),4367348). assertion_content_comment('tOboGo_NicotinamideRibosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","riboside",",","the","product","of","the","formation","of","a","glycosidic","bond","between","ribose","and","nicotinamide","."),4171810). assertion_content_comment('tOboGo_NicotinamideRibosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nicotinamide","riboside",",","the","product","of","the","formation","of","a","glycosidic","bond","between","ribose","and","nicotinamide","."),4229526). assertion_content_comment('tOboGo_NicotinamideRibosideHydrolaseActivity',s("Catalysis","of","the","reaction",":","nicotinamide","riboside","+","H2O","=","nicotinamide","+","D-ribose","."),4176947). assertion_content_comment('tOboGo_NicotinamideRibosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotinamide","riboside",",","the","product","of","the","formation","of","a","glycosidic","bond","between","ribose","and","nicotinamide","."),4171805). assertion_content_comment('tOboGo_NicotinamideRibosideTransporterActivity',s("Catalysis","of","the","transfer","of","nicotinamide","riboside",",","which","is","a","pyridine-3-carboxamide","covalently","bonded","to","a","ribose","sugar",",","from","one","side","of","a","membrane","to","the","other","."),4359489). assertion_content_comment('tOboGo_NicotinamideRibosideTransport',s("The","directed","movement","of","a","nicotinamide","riboside",",","which","is","a","pyridine-3-carboxamide","covalently","bonded","to","a","ribose","sugar",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4359480). assertion_content_comment('tOboGo_NicotinateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","NADP","(","+",")","+","nicotinate","=","6-hydroxynicotinate","+","H","(","+",")","+","NADPH","."),4271568). assertion_content_comment('tOboGo_NicotinateGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","nicotinate","+","UDP-D-glucose","=","N-","(","beta-D-glucosyl",")","nicotinate","+","UDP","."),4271555). assertion_content_comment('tOboGo_NicotinateNucleotideBiosyntheticProcessFromTryptophan',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinate","nucleotide","from","other","compounds",",","including","tryptophan","."),4239566). assertion_content_comment('tOboGo_NicotinateNucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","nucleotides",",","any","nucleotide","that","contains","combined","nicotinate","(","pyridine","3-carboxylic","acid",")"),4239524). assertion_content_comment('tOboGo_NicotinateNucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotinamide","nucleotides",",","any","nucleotide","that","contains","combined","nicotinate","(","pyridine","3-carboxylic","acid",",","or","niacin",")"),4239521). assertion_content_comment('tOboGo_NicotinateNucleotideSalvage',s("The","generation","of","nicotinate","nucleotide","without","de","novo","synthesis","."),4239539). assertion_content_comment('tOboGo_NicotinatePhosphoribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","diphosphate","+","nicotinate","D-ribonucleotide","=","5-phospho-alpha-D-ribose","1-diphosphate","+","H","(","+",")","+","nicotinate","."),4205159). assertion_content_comment('tOboGo_NicotineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotine",",","(","S",")","(","-",")","-3-","(","1-methyl-2-pyrrolidinyl",")","pyridine","."),4313441). assertion_content_comment('tOboGo_NicotineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nicotine",",","(","S",")","(","-",")","-3-","(","1-methyl-2-pyrrolidinyl",")","pyridine","."),4243569). assertion_content_comment('tOboGo_NicotineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","nicotine","+","acceptor","+","H2O","=","(","S",")","-6-hydroxynicotine","+","reduced","acceptor","."),4278163). assertion_content_comment('tOboGo_NicotineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotine",",","(","S",")","(","-",")","-3-","(","1-methyl-2-pyrrolidinyl",")","pyridine","."),4243565). assertion_content_comment('tOboGo_NicotinicAcidReceptorActivity',s("Combining","with","nicotinic","acid","to","initiate","a","change","in","cell","activity","."),4174640). assertion_content_comment('tOboGo_NicotinicAcidRibosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinic","acid","riboside",",","the","product","of","the","formation","of","a","glycosidic","bond","between","ribose","and","nicotinic","acid","."),4171783). assertion_content_comment('tOboGo_NicotinicAcidRibosideHydrolaseActivity',s("Catalysis","of","the","reaction",":","nicotinic","acid","riboside","+","H2O","=","nicotinic","acid","+","D-ribose","."),4176933). assertion_content_comment('tOboGo_NicotinicAcidRibosideKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","nicotinic","acid","riboside","=","ADP","+","nicotinic","acid","mononucleotide","."),4355370). assertion_content_comment('tOboGo_NicotinicAcidRibosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nicotinic","acid","riboside",",","the","product","of","the","formation","of","a","glycosidic","bond","between","ribose","and","nicotinic","acid","."),4171779). assertion_content_comment('tOboGo_NippleDevelopment',s("The","progression","of","the","nipple","over","time",",","from","its","formation","to","the","mature","structure",".","The","nipple","is","a","part","of","the","mammary","gland","that","protrudes","from","the","surface","ectoderm","."),4111862). assertion_content_comment('tOboGo_NippleMorphogenesis',s("The","process","in","which","the","nipple","is","generated","and","organized","."),4112086). assertion_content_comment('tOboGo_NippleSheathFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","nipple","sheath","from","the","unspecified","epidermis",".","This","process","begins","with","a","circular","ingrowth","of","the","epidermis","around","the","region","of","the","mammary","sprout",".","It","ends","before","the","region","begins","to","elevate","."),4112096). assertion_content_comment('tOboGo_NitrateAssimilation',s("The","nitrogen","metabolic","process","that","encompasses","the","uptake","of","nitrate","from","the","environment","and","reduction","to","ammonia",",","and","results","in","the","incorporation","of","nitrogen","derived","from","nitrate","into","cellular","substances","."),4151116). assertion_content_comment('tOboGo_NitrateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nitrates",",","inorganic","or","organic","salts","and","esters","of","nitric","acid","."),4325287). assertion_content_comment('tOboGo_NitrateEffluxTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nitrate","from","the","inside","of","the","cell","to","the","outside","of","the","cell","across","a","membrane","."),4336207). assertion_content_comment('tOboGo_Nitrate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","nitrate","(","out",")","+","H","+","(","out",")","=","nitrate","(","in",")","+","H","+","(","in",")"),4260854). assertion_content_comment('tOboGo_NitrateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitrates",",","inorganic","or","organic","salts","and","esters","of","nitric","acid","."),4151112). assertion_content_comment('tOboGo_NitrateReductaseActivity',s("Catalysis","of","the","reaction",":","nitrite","+","acceptor","=","nitrate","+","reduced","acceptor","."),4247492). assertion_content_comment('tOboGo_NitrateReductaseComplex',s("An","enzyme","complex","that","catalyzes","the","formation","of","nitrate","from","nitrite","with","the","concomitant","reduction","of","an","acceptor","."),4259869). assertion_content_comment('tOboGo_NitrateReductaseCytochromeActivity',s("Catalysis","of","the","reaction",":","ferrocytochrome","+","nitrate","=","ferricytochrome","+","nitrite","."),4271544). assertion_content_comment('tOboGo_NitrateReductaseNADHActivity',s("Catalysis","of","the","reaction",":","nitrite","+","NAD","+","+","H2O","=","nitrate","+","NADH","+","H","+"),4260760). assertion_content_comment('tOboGo_NitrateReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","nitrite","+","NAD","(","P",")","+","+","H2O","=","nitrate","+","NAD","(","P",")","H","+","H","+"),4266008). assertion_content_comment('tOboGo_NitrateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nitrate","ions","(","NO3-",")","from","one","side","of","a","membrane","to","the","other","."),4182668). assertion_content_comment('tOboGo_NitrateTransport',s("The","directed","movement","of","nitrate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4182649). assertion_content_comment('tOboGo_NitricOxideBinding',s("Interacting","selectively","and","non-covalently","with","nitric","oxide","(","NO",")"),4180400). assertion_content_comment('tOboGo_NitricOxideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nitric","oxide",",","nitrogen","monoxide","(","NO",")",",","a","colorless","gas","only","slightly","soluble","in","water","."),4089482). assertion_content_comment('tOboGo_NitricOxideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nitric","oxide",",","nitrogen","monoxide","(","NO",")",",","a","colorless","gas","only","slightly","soluble","in","water","."),4354353). assertion_content_comment('tOboGo_NitricOxideDioxygenaseActivity',s("Catalysis","of","the","reaction",":","2","NO","+","2","O2","+","NADPH","+","H","+","=","2","nitrate","+","NADP","+"),4247480). assertion_content_comment('tOboGo_NitricOxideHomeostasis',s("A","homeostatic","process","involved","in","the","maintenance","of","an","internal","steady","state","of","nitric","oxide","within","an","organism","or","cell","."),4082511). assertion_content_comment('tOboGo_NitricOxideMediatedSignalTransduction',s("A","series","of","molecular","signals","mediated","by","the","detection","of","nitric","oxide","(","NO",")"),4024742). assertion_content_comment('tOboGo_NitricOxideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitric","oxide",",","nitrogen","monoxide","(","NO",")",",","a","colorless","gas","only","slightly","soluble","in","water","."),4089479). assertion_content_comment('tOboGo_NitricOxideProductionInvolvedInInflammatoryResponse',s("The","synthesis","or","release","of","nitric","oxide","following","a","stimulus","as","part","of","an","inflammatory","response",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4381678). assertion_content_comment('tOboGo_NitricOxideReductaseActivity',s("Catalysis","of","the","reaction",":","nitrous","oxide","+","acceptor","+","H2O","=","2","nitric","oxide","+","reduced","acceptor","."),4302458). assertion_content_comment('tOboGo_NitricOxideStorage',s("The","accumulation","and","maintenance","in","cells","or","tissues","of","nitric","oxide","(","NO",")","Nitric","oxide","is","stored","in","the","form","of","dinitrosyl-iron","complexes",",","which","are","stabilized",",","and","possibly","sequestered",",","by","binding","to","glutathione","S-transferase","proteins","."),4082522). assertion_content_comment('tOboGo_NitricOxideTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","nitric","oxide",",","nitrogen","monoxide",",","from","one","side","of","a","membrane","to","the","other","."),4311402). assertion_content_comment('tOboGo_NitricOxideTransport',s("The","directed","movement","of","nitric","oxide",",","nitrogen","monoxide",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4311423). assertion_content_comment('tOboGo_NitrilaseActivity',s("Catalysis","of","the","reaction",":","a","nitrile","+","H2O","=","a","carboxylate","+","NH3",".","Acts","on","a","wide","range","of","aromatic","nitriles","including","(","indole-3-yl",")","-acetonitrile","and","some","aliphatic","nitriles",",","and","on","the","corresponding","acid","amides","."),4182589). assertion_content_comment('tOboGo_NitrileBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","nitrile",",","an","organic","compound","containing","trivalent","nitrogen","attached","to","one","carbon","atom","."),4182319). assertion_content_comment('tOboGo_NitrileCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","nitrile",",","an","organic","compound","containing","trivalent","nitrogen","attached","to","one","carbon","atom","."),4238061). assertion_content_comment('tOboGo_NitrileHydrataseActivity',s("Catalysis","of","the","reaction",":","an","aliphatic","amide","=","a","nitrile","+","H2O","."),4181441). assertion_content_comment('tOboGo_NitrileMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitriles",",","an","organic","compound","containing","trivalent","nitrogen","attached","to","one","carbon","atom",".","The","nitriles","are","named","with","reference","to","the","acids","produced","by","their","decomposition",";","for","example",",","hydrocyanic","acid","is","formic","nitrile",",","and","methyl","cyanide","is","acetic","nitrile","."),4182316). assertion_content_comment('tOboGo_NitrilotriacetateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","nitrilotriacetate","+","OH-","=","H","+","+","2","e-","+","glyoxylate","+","iminodiacetate","."),4278176). assertion_content_comment('tOboGo_NitrilotriacetateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitrilotriacetate",",","an","aminotricarboxylic","acid","that","binds","bivalent","metal","ions","in","a","ratio","of","1",":","1",".","As","an","important","industrial","chelating","agent",",","NTA","has","been","widely","used","for","various","radionuclide","processing","and","decontamination","procedures",",","such","as","textile",",","paper","and","pulp","processing","and","water","treatment","."),4272199). assertion_content_comment('tOboGo_NitrilotriacetateMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","nitrilotriacetate","+","NADH","+","H","+","+","O2","=","NAD","+","+","H2O","+","glyoxylate","+","iminodiacetate","."),4278415). assertion_content_comment('tOboGo_NitriteEffluxTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nitrite","from","the","inside","of","the","cell","to","the","outside","of","the","cell","across","a","membrane","."),4292761). assertion_content_comment('tOboGo_NitriteNitratePorterActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4296536). assertion_content_comment('tOboGo_NitriteReductaseComplexNADPH',s("Complex","that","possesses","nitrite","reductase","[","NAD","(","P",")","H","]","activity","."),4259658). assertion_content_comment('tOboGo_NitriteReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","ammonium","hydroxide","+","3","NAD","(","P",")","+","+","H2O","=","nitrite","+","3","NAD","(","P",")","H","+","3","H","+"),4247595). assertion_content_comment('tOboGo_NitriteTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nitrite","(","NO2-",")","ions","from","one","side","of","a","membrane","to","the","other","."),4292743). assertion_content_comment('tOboGo_NitriteTransport',s("The","directed","movement","of","nitrite","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290663). assertion_content_comment('tOboGo_NitriteUptakeTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nitrite","from","the","outside","of","a","cell","to","the","inside","of","the","cell","across","a","membrane","."),4292748). assertion_content_comment('tOboGo_NitroalkaneOxidaseActivity',s("Catalysis","of","the","reaction",":","nitroalkane","+","H2O","+","O2","=","an","aldehyde","or","ketone","+","nitrite","+","H2O2","."),4192084). assertion_content_comment('tOboGo_NitrobenzeneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitrobenzene","(","nitrobenzol",")",",","a","derivative","of","benzene","with","an","NO2","group","attached","to","the","ring",".","It","is","a","yellow","aromatic","liquid","used","in","perfumery","and","manufactured","in","large","quantities","in","the","preparation","of","aniline","."),4272156). assertion_content_comment('tOboGo_NitrobenzeneNitroreductaseActivity',s("Catalysis","of","the","reaction",":","nitrobenzene","+","2","NADPH","+","2","H","+","=","hydroxyaminobenzene","+","2","NADP","+","+","H2O","."),4279002). assertion_content_comment('tOboGo_NitrobenzoateNitroreductaseActivity',s("Catalysis","of","the","reaction",":","o-nitrobenzoate","+","NADPH","+","H","+","=","o-hydroxylaminobenzoate","+","NADP","+"),4352841). assertion_content_comment('tOboGo_NitroethaneOxidaseActivity',s("Catalysis","of","the","reaction",":","nitroethane","+","H2O","+","O2","=","acetaldehyde","+","nitrite","+","H2O2","."),4271463). assertion_content_comment('tOboGo_NitrogenaseActivity',s("Catalysis","of","the","reaction",":","8","reduced","ferredoxin","+","8","H","+","+","nitrogen","+","16","ATP","=","8","oxidized","ferredoxin","+","2","NH3","+","16","ADP","+","16","phosphate","."),4301370). assertion_content_comment('tOboGo_NitrogenaseComplex',s("An","enzyme","complex","composed","of","two","proteins",",","dinitrogenase","and","nitrogenase","reductase",";","dinitrogenase","is","tetrameric","with","an","alpha2-beta2","structure","and","nitrogenase","reductase","is","a","homodimer",",","and","both","are","associated","with","metal","ions",",","which","differ","between","species",".","Both","proteins","are","required","for","the","enzyme","activity","of","the","complex",",","the","formation","of","oxidized","ferredoxin","and","ammonia","from","reduced","ferredoxin","and","nitrogen","."),4301396). assertion_content_comment('tOboGo_NitrogenaseFlavodoxinActivity',s("Catalysis","of","the","reaction",":","6","reduced","flavodoxin","+","6","H","+","+","N2","+","n","ATP","=","6","oxidized","flavodoxin","+","2","NH3","+","n","ADP","+","n","phosphate","."),4271495). assertion_content_comment('tOboGo_NitrogenCataboliteActivationOfTranscriptionFromRNAPolymeraseIIPromoter',s("A","transcription","regulation","process","in","which","the","presence","of","one","nitrogen","source","leads","to","an","increase","in","the","frequency",",","rate",",","or","extent","of","transcription",",","from","an","RNA","polymerase","II","promoter",",","of","specific","genes","involved","in","the","metabolism","of","other","nitrogen","sources","."),4355716). assertion_content_comment('tOboGo_NitrogenCataboliteActivationOfTranscription',s("A","transcription","regulation","process","in","which","the","presence","of","one","nitrogen","source","leads","to","an","increase","in","the","frequency",",","rate",",","or","extent","of","transcription","of","specific","genes","involved","in","the","metabolism","of","other","nitrogen","sources","."),4155504). assertion_content_comment('tOboGo_NitrogenCataboliteRegulationOfTranscriptionFromRNAPolymeraseIIPromoter',s("A","transcription","regulation","process","in","which","the","presence","of","one","nitrogen","source","leads","to","the","modulation","of","the","frequency",",","rate",",","or","extent","of","transcription",",","from","an","RNA","polymerase","II","promoter",",","of","specific","genes","involved","in","the","metabolism","of","other","nitrogen","sources","."),4355701). assertion_content_comment('tOboGo_NitrogenCataboliteRegulationOfTranscription',s("A","transcription","regulation","process","in","which","the","presence","of","one","nitrogen","source","leads","to","the","modulation","of","the","frequency",",","rate",",","or","extent","of","transcription","of","specific","genes","involved","in","the","metabolism","of","other","nitrogen","sources","."),4155501). assertion_content_comment('tOboGo_NitrogenCataboliteRepressionOfTranscriptionFromRNAPolymeraseIIPromoter',s("A","transcription","regulation","process","in","which","the","presence","of","one","nitrogen","source","leads","to","a","decrease","in","the","frequency",",","rate",",","or","extent","of","transcription",",","from","an","RNA","polymerase","II","promoter",",","of","specific","genes","involved","in","the","metabolism","of","other","nitrogen","sources","."),4355705). assertion_content_comment('tOboGo_NitrogenCataboliteRepressionOfTranscription',s("A","transcription","regulation","process","in","which","the","presence","of","one","nitrogen","source","leads","to","a","decrease","in","the","frequency",",","rate",",","or","extent","of","transcription","of","specific","genes","involved","in","the","metabolism","of","other","nitrogen","sources","."),4155673). assertion_content_comment('tOboGo_NitrogenCompoundMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organic","or","inorganic","compounds","that","contain","nitrogen",",","including","(","but","not","limited","to",")","nitrogen","fixation",",","nitrification",",","denitrification",",","assimilatory/dissimilatory","nitrate","reduction","and","the","interconversion","of","nitrogenous","organic","matter","and","ammonium","."),3969006). assertion_content_comment('tOboGo_NitrogenCompoundTransport',s("The","directed","movement","of","nitrogen-containing","compounds","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990579). assertion_content_comment('tOboGo_NitrogenCycleMetabolicProcess',s("A","nitrogen","compound","metabolic","process","that","contributes","to","the","nitrogen","cycle",".","The","nitrogen","cycle","is","a","series","of","metabolic","pathways","by","which","nitrogen","is","converted","between","various","forms","and","redox","states",";","it","encompasses","pathways","in","which","nitrogen","is","acted","upon","directly",",","such","as","nitrification",",","denitrification",",","nitrogen","fixation",",","and","mineralization","."),4075495). assertion_content_comment('tOboGo_NitrogenFixation',s("The","process","in","which","nitrogen","is","taken","from","its","relatively","inert","molecular","form","(","N2",")","in","the","atmosphere","and","converted","into","nitrogen","compounds","useful","for","other","chemical","processes",",","such","as","ammonia",",","nitrate","and","nitrogen","dioxide","."),4260257). assertion_content_comment('tOboGo_NitrogenousCompoundFermentation',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","nitrogen-containing","compound",",","yielding","energy","in","the","form","of","ATP","."),4244288). assertion_content_comment('tOboGo_NitrogenUtilization',s("A","series","of","processes","that","forms","an","integrated","mechanism","by","which","a","cell","or","an","organism","detects","the","depletion","of","primary","nitrogen","source",",","usually","ammonia",",","and","then","activates","genes","to","scavenge","the","last","traces","of","the","primary","nitrogen","source","and","to","transport","and","metabolize","alternative","nitrogen","sources",".","The","utilization","process","begins","when","the","cell","or","organism","detects","nitrogen","levels",",","includes","the","activation","of","genes","whose","products","detect",",","transport","or","metabolize","nitrogen-containing","substances",",","and","ends","when","nitrogen","is","incorporated","into","the","cell","or","organism","'","s","metabolism","."),4014295). assertion_content_comment('tOboGo_NitroglycerinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitroglycerin",",","a","well-known","nitrate","ester","and","an","important","component","of","dynamite","and","other","propellants",".","Toxic","to","algae",",","invertebrate",",","and","vertebrates","."),4272214). assertion_content_comment('tOboGo_NitroglycerinReductaseActivity',s("Catalysis","of","the","removal","of","one","or","more","nitrite","(","NO2-",")","groups","from","nitroglycerin","or","a","derivative","."),4278973). assertion_content_comment('tOboGo_NitronateMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","ethylnitronate","+","FMNH","(","2",")","+","O","(","2",")","=","acetaldehyde","+","FMN","+","H","(","2",")","O","+","H","(","+",")","+","nitrite","."),4275466). assertion_content_comment('tOboGo_NitrotolueneBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nitrotoluene",",","any","methylbenzene","molecule","with","NO2","group","(","s",")","attached","."),4353279). assertion_content_comment('tOboGo_NitrotolueneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nitrotoluene",",","any","methylbenzene","molecule","with","NO2","group","(","s",")","attached","."),4238017). assertion_content_comment('tOboGo_NitrotolueneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitrotoluene",",","any","methylbenzene","molecule","with","NO2","group","(","s",")","attached","."),4237999). assertion_content_comment('tOboGo_NKTCellActivationInvolvedInImmuneResponse',s("The","change","in","morphology","and","behavior","of","a","mature","or","immature","natural","killer","T","cell","resulting","from","exposure","to","a","mitogen",",","cytokine",",","chemokine",",","cellular","ligand",",","or","an","antigen","for","which","it","is","specific",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4378381). assertion_content_comment('tOboGo_NKTCellActivation',s("The","change","in","morphology","and","behavior","of","a","mature","or","immature","natural","killer","T","cell","resulting","from","exposure","to","a","mitogen",",","cytokine",",","chemokine",",","cellular","ligand",",","or","an","antigen","for","which","it","is","specific","."),4119369). assertion_content_comment('tOboGo_NKTCellDifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","NK","T","cell","."),3994122). assertion_content_comment('tOboGo_NKTCellLineageCommitment',s("The","process","in","which","a","pro-T","cell","becomes","committed","to","becoming","an","NK","T","cell","."),3994140). assertion_content_comment('tOboGo_NKTCellProliferationInvolvedInImmuneResponse',s("The","expansion","of","a","NK","T","cell","population","by","cell","division","as","part","of","an","immune","response","."),4378420). assertion_content_comment('tOboGo_NKTCellProliferation',s("The","expansion","of","a","NK","T","cell","population","by","cell","division","."),4119786). assertion_content_comment('tOboGo_NMNNucleosidaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","nicotinamide","mononucleotide","=","D-ribose","5-phosphate","+","H","(","+",")","+","nicotinamide","."),4237675). assertion_content_comment('tOboGo_NMSComplex',s("A","supercomplex","formed","by","the","association","of","two","subcomplexes","(","known","as","MIND","and","Ndc80","in","Schizosaccharomyces",")","with","additional","proteins","at","the","kinetochores","of","condensed","nuclear","chromosomes","."),4060207). assertion_content_comment('tOboGo_NocComplex',s("Any","of","several","heterodimers","containing","one","or","two","Noc","proteins",",","associated","with","preribosomal","complexes",";","involved","in","ribosome","biogenesis","."),4051898). assertion_content_comment('tOboGo_NociceptinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","nociceptin","receptor","."),4324123). assertion_content_comment('tOboGo_NodeOfRanvier',s("An","axon","part","that","is","a","gap","in","the","myelin","where","voltage-gated","sodium","channels","cluster","and","saltatory","conduction","is","executed","."),4066498). assertion_content_comment('tOboGo_Nodulation',s("The","formation","of","nitrogen-fixing","root","nodules","on","plant","roots","."),4022180). assertion_content_comment('tOboGo_NoduleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","nodule","are","generated","and","organized","."),4022192). assertion_content_comment('tOboGo_NonahemeCytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259295). assertion_content_comment('tOboGo_NonassociativeLearning',s("A","simple","form","of","learning","whereby","the","repeated","presence","of","a","stimulus","leads","to","a","change","in","the","probability","or","strength","of","the","response","to","that","stimulus",".","There","is","no","association","of","one","type","of","stimulus","with","another",",","rather","it","is","a","generalized","response","to","the","environment","."),4361935). assertion_content_comment('tOboGo_NoncyclicPhotosyntheticPhosphorylation',s("A","photosynthetic","phosphorylation","process","in","which","ATP","synthesis","is","linked","to","the","transport","of","electrons","from","water","to","NADP","+","with","the","production","of","NADPH","and","dioxygen","(","O2",")","Involves","photosystem","I","and","photosystem","II","."),4262786). assertion_content_comment('tOboGo_NonexocytoticVesicleDocking',s("OBSOLETE",".","The","initial","attachment","of","a","transport","vesicle","membrane","to","a","target","membrane",",","mediated","by","proteins","protruding","from","the","membrane","of","the","vesicle","and","the","target","membrane",",","during","a","non-exocytotic","process","."),4384785). assertion_content_comment('tOboGo_NonfunctionalRRNADecay',s("An","rRNA","catabolic","process","that","results","in","the","targeted","detection","and","degradation","of","aberrant","rRNAs","contained","within","translationally","defective","ribosomes",",","thereby","acting","as","a","quality-control","system","."),4177443). assertion_content_comment('tOboGo_NonhomologousEndJoiningComplex',s("A","protein","complex","that","plays","a","role","in","DNA","double-strand","break","repair","via","nonhomologous","end","joining",".","Such","complexes","typically","contain","a","specialized","DNA","ligase","(","e.g",".","Lig4","in","eukaryotes",")","and","one","or","more","proteins","that","bind","to","DNA","ends","."),4175472). assertion_content_comment('tOboGo_NonmotilePrimaryCilium',s("A","primary","cilium","which","contains","a","variable","array","of","axonemal","microtubules","but","does","not","contain","molecular","motors",".","Nonmotile","primary","cilia","are","found","on","many","different","cell","types","and","function","as","sensory","organelles","that","concentrate","and","organize","sensory","signaling","molecules","."),4077627). assertion_content_comment('tOboGo_NonphotochemicalQuenching',s("The","process","to","maintain","the","balance","between","dissipation","and","utilization","of","light","energy","to","minimize","generation","of","oxidizing","molecules",",","thereby","protecting","the","plant","against","photo-oxidative","damage","."),4333906). assertion_content_comment('tOboGo_NonproteinAminoAcidBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","amino","acid","that","does","not","normally","occur","as","a","constituent","residue","of","proteins","."),4234288). assertion_content_comment('tOboGo_NonproteinAminoAcidCatabolicProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","amino","acid","not","found",",","or","rarely","found",",","in","peptide","linkage","in","proteins","."),4234304). assertion_content_comment('tOboGo_NonproteinAminoAcidMetabolicProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","involving","any","amino","acid","not","found",",","or","rarely","found",",","in","peptide","linkage","in","proteins","."),4234275). assertion_content_comment('tOboGo_NonribosomalPeptideBiosyntheticProcess',s("The","biosynthetic","process","in","which","peptide","bond","formation","occurs","in","the","absence","of","the","translational","machinery",".","Examples","include","the","synthesis","of","antibiotic","peptides",",","and","glutathione","."),4094107). assertion_content_comment('tOboGo_NonspecificRNAPolymeraseIITranscriptionFactorActivity',s("Any","function","that","supports","transcription","of","genes","by","RNA","polymerase","II",",","and","is","not","specific","to","a","particular","gene","or","gene","set","."),4303705). assertion_content_comment('tOboGo_NopalineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nopaline","(","N-","(","I-carboxy-4-guanidinobutyl",")","glutamic","acid",")",",","a","rare","amino-acid","derivative","."),4241511). assertion_content_comment('tOboGo_NopalineCatabolicProcessToProline',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nopaline","into","other","compounds",",","including","proline","."),4313331). assertion_content_comment('tOboGo_NopalineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nopaline",",","(","N-","(","I-carboxy-4-guanidinobutyl",")","glutamic","acid",")",",","a","rare","amino-acid","derivative","."),4241508). assertion_content_comment('tOboGo_NoradrenergicNeuronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","noradrenergic","neuron","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4005804). assertion_content_comment('tOboGo_NoradrenergicNeuronDifferentiationInvolvedInBrainstemDevelopment',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","noradrenergic","neuron","that","is","part","of","the","brainstem","."),4005773). assertion_content_comment('tOboGo_NoradrenergicNeuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","noradrenergic","neuron",",","a","neuron","that","secretes","noradrenaline","."),4005760). assertion_content_comment('tOboGo_NoradrenergicNeuronFateCommitmentInvolvedInBrainstemDevelopment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","noradrenergic","neuron","that","is","part","of","the","brainstem","."),4005794). assertion_content_comment('tOboGo_NoradrenergicNeuronFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","noradrenergic","neuron","."),4005790). assertion_content_comment('tOboGo_NorepinephrineBinding',s("Interacting","selectively","and","non-covalently","with","norepinephrine",",","(","3",",","4-dihydroxyphenyl-2-aminoethanol",")",",","a","hormone","secreted","by","the","adrenal","medulla","and","a","neurotransmitter","in","the","sympathetic","peripheral","nervous","system","and","in","some","tracts","of","the","CNS",".","It","is","also","the","biosynthetic","precursor","of","epinephrine","."),4286008). assertion_content_comment('tOboGo_NorepinephrineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","norepinephrine",",","a","hormone","secreted","by","the","adrenal","medulla",",","and","a","neurotransmitter","in","the","sympathetic","peripheral","nervous","system","and","in","some","tracts","in","the","central","nervous","system",".","It","is","also","the","demethylated","biosynthetic","precursor","of","epinephrine","."),4312365). assertion_content_comment('tOboGo_NorepinephrineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","norepinephrine",",","a","hormone","secreted","by","the","adrenal","medulla",",","and","a","neurotransmitter","in","the","sympathetic","peripheral","nervous","system","and","in","some","tracts","in","the","central","nervous","system",".","It","is","also","the","demethylated","biosynthetic","precursor","of","epinephrine","."),4312383). assertion_content_comment('tOboGo_NorepinephrineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","norepinephrine",",","a","hormone","secreted","by","the","adrenal","medulla",",","and","a","neurotransmitter","in","the","sympathetic","peripheral","nervous","system","and","in","some","tracts","in","the","central","nervous","system",".","It","is","also","the","demethylated","biosynthetic","precursor","of","epinephrine","."),4312357). assertion_content_comment('tOboGo_NorepinephrineSecretion',s("The","regulated","release","of","norepinephrine","by","a","cell","or","group","of","cells",".","Norepinephrine","is","a","catecholamine","and","it","acts","as","a","hormone","and","as","a","neurotransmitter","of","most","of","the","sympathetic","nervous","system","."),4026648). assertion_content_comment('tOboGo_Norepinephrine_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","norepinephrine","(","out",")","+","Na","+","(","out",")","=","norepinephrine","(","in",")","+","Na","+","(","in",")"),4216313). assertion_content_comment('tOboGo_NorepinephrineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","norepinephrine","from","one","side","of","the","membrane","to","the","other",".","Norepinephrine","(","3",",","4-dihydroxyphenyl-2-aminoethanol",")","is","a","hormone","secreted","by","the","adrenal","medulla","and","a","neurotransmitter","in","the","sympathetic","peripheral","nervous","system","and","in","some","tracts","of","the","CNS",".","It","is","also","the","biosynthetic","precursor","of","epinephrine","."),4216237). assertion_content_comment('tOboGo_NorepinephrineTransport',s("The","directed","movement","of","norepinephrine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Norepinephrine","(","3",",","4-dihydroxyphenyl-2-aminoethanol",")","is","a","hormone","secreted","by","the","adrenal","medulla","and","a","neurotransmitter","in","the","sympathetic","peripheral","nervous","system","and","in","some","tracts","of","the","CNS",".","It","is","also","the","biosynthetic","precursor","of","epinephrine","."),4026633). assertion_content_comment('tOboGo_NorepinephrineUptake',s("The","directed","movement","of","norepinephrine","into","a","cell",",","typically","presynaptic","neurons","or","glial","cells",".","Norepinephrine","(","3",",","4-dihydroxyphenyl-2-aminoethanol",")","is","a","hormone","secreted","by","the","adrenal","medulla","and","a","neurotransmitter","in","the","sympathetic","peripheral","nervous","system","and","in","some","tracts","of","the","CNS",".","It","is","also","the","biosynthetic","precursor","of","epinephrine","."),4121477). assertion_content_comment('tOboGo_NoseDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","nose","over","time",",","from","its","formation","to","the","mature","structure",".","The","nose","is","the","specialized","structure","of","the","face","that","serves","as","the","organ","of","the","sense","of","smell","and","as","part","of","the","respiratory","system",".","Includes","the","nasi","externus","(","external","nose",")","and","cavitas","nasi","(","nasal","cavity",")"),4061416). assertion_content_comment('tOboGo_NoseMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","nose","are","generated","and","organized",".","The","nose","is","the","specialized","structure","of","the","face","that","serves","as","the","organ","of","the","sense","of","smell","and","as","part","of","the","respiratory","system",".","Includes","the","nasi","externus","(","external","nose",")","and","cavitas","nasi","(","nasal","cavity",")"),4094783). assertion_content_comment('tOboGo_NotchBinding',s("Interacting","selectively","and","non-covalently","with","the","Notch","(","N",")","protein",",","a","surface","receptor","."),4214847). assertion_content_comment('tOboGo_NotchReceptorProcessing',s("The","series","of","successive","proteolytic","cleavages","of","the","Notch","protein",",","which","result","in","an","active","form","of","the","receptor","."),4083529). assertion_content_comment('tOboGo_NotchSignalingInvolvedInHeartDevelopment',s("The","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","and","contributing","to","the","progression","of","the","heart","over","time","."),4001220). assertion_content_comment('tOboGo_NotchSignalingPathwayInvolvedInArterialEndothelialCellFateCommitment',s("The","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","and","contributing","to","the","commitment","of","a","cell","to","an","arterial","endothelial","cell","fate","."),4113842). assertion_content_comment('tOboGo_NotchSignalingPathwayInvolvedInForebrainNeuroblastDivision',s("The","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","that","contributes","to","the","self","renewal","of","neuroblasts","in","the","forebrain","."),4047437). assertion_content_comment('tOboGo_NotchSignalingPathwayInvolvedInForebrainNeuronFateCommitment',s("The","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","that","contributes","to","the","commitment","of","a","neuroblast","to","a","neuronal","fate",".","The","neuron","will","reside","in","the","forebrain","."),4047568). assertion_content_comment('tOboGo_NotchSignalingPathwayInvolvedInHeartInduction',s("The","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","that","contributes","to","heart","induction","."),4003339). assertion_content_comment('tOboGo_NotchSignalingPathwayInvolvedInRegulationOfSecondaryHeartFieldCardioblastProliferation',s("The","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","contributing","to","the","modulation","of","the","frequency",",","rate","or","extent","of","cardioblast","proliferation",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4001224). assertion_content_comment('tOboGo_NotchSignalingPathway',s("The","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","."),4001210). assertion_content_comment('tOboGo_NotochordCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","notochord","cell","over","time",",","from","its","formation","to","its","mature","structure",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","specific","fate","."),4109109). assertion_content_comment('tOboGo_NotochordCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","cells","that","make","up","the","notochord",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","notochord","cell","fate","."),4109099). assertion_content_comment('tOboGo_NotochordCellVacuolation',s("The","assembly","and","arrangement","of","a","vacuole","within","a","cell","of","the","notochord","."),4109129). assertion_content_comment('tOboGo_NotochordDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","notochord","over","time",",","from","its","formation","to","the","mature","structure",".","The","notochord","is","a","mesoderm-derived","structure","located","ventral","of","the","developing","nerve","cord",".","In","vertebrates",",","the","notochord","serves","as","a","core","around","which","other","mesodermal","cells","form","the","vertebrae",".","In","the","most","primitive","chordates",",","which","lack","vertebrae",",","the","notochord","persists","as","a","substitute","for","a","vertebral","column","."),4039086). assertion_content_comment('tOboGo_NotochordFormation',s("The","formation","of","the","notochord","from","the","chordamesoderm",".","The","notochord","is","composed","of","large","cells","packed","within","a","firm","connective","tissue","sheath","and","is","found","in","all","chordates","at","the","ventral","surface","of","the","neural","tube",".","In","vertebrates",",","the","notochord","contributes","to","the","vertebral","column","."),4039099). assertion_content_comment('tOboGo_NotochordMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","notochord","are","generated","and","organized",".","The","notochord","is","a","mesoderm-derived","structure","located","ventral","of","the","developing","nerve","cord",".","In","vertebrates",",","the","notochord","serves","as","a","core","around","which","other","mesodermal","cells","form","the","vertebrae",".","In","the","most","primitive","chordates",",","which","lack","vertebrae",",","the","notochord","persists","as","a","substitute","for","a","vertebral","column","."),4039088). assertion_content_comment('tOboGo_NotochordRegression',s("The","developmental","process","in","which","the","stucture","of","the","notochord","is","destroyed","in","an","embryo","."),4109080). assertion_content_comment('tOboGo_NotumCellFateSpecification',s("The","process","in","which","a","cell","in","the","larval","wing","imaginal","disc","becomes","capable","of","differentiating","autonomously","into","a","notum","cell",",","if","left","in","its","normal","environment","."),4071409). assertion_content_comment('tOboGo_NotumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","dorsal","part","of","the","body","over","time",",","from","its","formation","to","the","mature","structure","."),4017992). assertion_content_comment('tOboGo_NotumMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","dorsal","part","of","the","body","are","generated","and","organized","."),4105372). assertion_content_comment('tOboGo_NovobiocinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","novobiocin",",","a","coumarin","antibiotic","produced","by","the","bacterium","Gyrasestreptomyces","spheroides",",","that","acts","by","inhibiting","DNA","gyrase","."),4325233). assertion_content_comment('tOboGo_NovobiocinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","novobiocin",",","a","coumarin","antibiotic","produced","by","the","bacterium","Gyrasestreptomyces","spheroides",",","that","acts","by","inhibiting","DNA","gyrase","."),4325220). assertion_content_comment('tOboGo_NpBAFComplex',s("A","SWI/SNF-type","complex","that","is","found","in","neural","stem","or","progenitor","cells",",","and","in","human","contains","actin","and","proteins","encoded","by","the","ARID1A/BAF250A","or","ARID1B/BAF250B",",","SMARCD1/BAF60A",",","SMARCD3/BAF60C",",","SMARCA2/BRM/BAF190B",",","SMARCA4/BRG1/BAF190A",",","SMARCB1/BAF47",",","SMARCC1/BAF155",",","SMARCE1/BAF57",",","SMARCC2/BAF170",",","PHF10/BAF45A",",","ACTL6A/BAF53A","genes",".","The","npBAF","complex","is","essential","for","the","self-renewal/proliferative","capacity","of","the","multipotent","neural","stem","cells","."),4171199). assertion_content_comment('tOboGo_Nrd1Complex',s("A","complex","that","functions","in","transcription","termination","of","RNA","polymerase","II","transcribed","non-coding","RNAs",".","This","complex","interacts","with","the","carboxy-terminal","domain","(","CTD",")","of","PolII","and","the","terminator","sequences","in","the","nascent","RNA","transcript",".","In","yeast","this","complex","consists","of","Nrd1p",",","Nab3p",",","and","Sen1p","."),4380252). assertion_content_comment('tOboGo_NuA3HistoneAcetyltransferaseComplex',s("A","Gcn5-independent","multisubunit","complex","that","catalyzes","the","acetylation","of","histone","H3",".","The","budding","yeast","complex","includes","Sas3p",",","Taf30p",",","and","Yng1p","."),4347781). assertion_content_comment('tOboGo_NuA4HistoneAcetyltransferaseComplex',s("A","complex","having","histone","acetylase","activity","on","chromatin",",","as","well","as","ATPase",",","DNA","helicase","and","structural","DNA","binding","activities",".","The","complex","is","thought","to","be","involved","in","double-strand","DNA","break","repair",".","Subunits","of","the","human","complex","include","HTATIP/TIP60",",","TRRAP",",","RUVBL1",",","BUVBL2",",","beta-actin","and","BAF53/ACTL6A",".","In","yeast",",","the","complex","has","13","subunits",",","including","the","catalytic","subunit","Esa1","(","homologous","to","human","Tip60",")"),4382671). assertion_content_comment('tOboGo_NuclearArylHydrocarbonReceptorComplex',s("An","aryl","hydrocarbon","receptor","(","AhR",")","complex","found","in","the","nucleus",";",";","consists","of","ligand-bound","AhR","and","the","aryl","hydrocarbon","receptor","nuclear","translocator","(","ARNT",")"),4349508). assertion_content_comment('tOboGo_NuclearAxialExpansion',s("The","stepwise","asymmetric","spreading","out","of","nuclei","internally","along","the","anterior-posterior","axis","of","the","developing","insect","embryo","during","mitotic","cycles","4","to","6",".","This","movement","leads","to","the","distribution","of","nuclei","in","a","hollow","ellipsoid","underlying","the","cortex","."),4381956). assertion_content_comment('tOboGo_NuclearBodyOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","any","of","the","extra-nucleolar","nuclear","domains","usually","visualized","by","confocal","microscopy","and","fluorescent","antibodies","to","specific","proteins","."),4307756). assertion_content_comment('tOboGo_NuclearBody',s("Extra-nucleolar","nuclear","domains","usually","visualized","by","confocal","microscopy","and","fluorescent","antibodies","to","specific","proteins","."),4126607). assertion_content_comment('tOboGo_NuclearCapBindingComplex',s("A","conserved","heterodimeric","protein","complex","that","binds","to","the","5","'","terminal","cap","structure","m7G","(","5","'",")","ppp","(","5","'",")","N","of","nascent","eukaryotic","RNA","polymerase","II","transcripts","such","as","pre-mRNA","and","U","snRNA",".","The","consists","of","proteins","known","as","CBP20","and","CBP80",",","binds","to","cap","structures","in","the","nucleus",",","and","is","involved","in","pre-mRNA","splicing",",","3","'","-end","formation",",","and","RNA","nuclear","export","."),4221693). assertion_content_comment('tOboGo_NuclearCentromericHeterochromatin',s("A","region","of","heterochromatin","located","near","the","centromere","of","a","chromosome","in","the","nucleus","."),3992985). assertion_content_comment('tOboGo_NuclearChromatin',s("The","ordered","and","organized","complex","of","DNA","and","protein","that","forms","the","chromosome","in","the","nucleus","."),3978234). assertion_content_comment('tOboGo_NuclearChromosomePart',s("Any","constituent","part","of","a","nuclear","chromosome",",","a","chromosome","found","in","the","nucleus","of","a","eukaryotic","cell","."),3978170). assertion_content_comment('tOboGo_NuclearChromosome',s("A","chromosome","found","in","the","nucleus","of","a","eukaryotic","cell","."),3973108). assertion_content_comment('tOboGo_NuclearChromosomeTelomericRegion',s("The","terminal","region","of","a","linear","chromosome","in","the","nucleus","that","includes","the","telomeric","DNA","repeats","and","associated","proteins","."),3978492). assertion_content_comment('tOboGo_NuclearCluster',s("Discrete","hetero-chromatin-containing","foci","in","interphase","nuclei",",","which","comprise","clusters","of","centromeric","DNA","(","as","defined","by","gamma-satellite","sequences","and","the","abundance","of","heterochromatin","protein","1","(","HP-1",")"),3992996). assertion_content_comment('tOboGo_NuclearCohesinComplex',s("A","cohesin","complex","required","for","cohesion","between","sister","chromatids","that","remain","in","the","nucleus","."),3978378). assertion_content_comment('tOboGo_NuclearCondensinComplex',s("A","multisubunit","protein","complex","that","plays","a","central","role","in","the","condensation","of","chromosomes","that","remain","in","the","nucleus","."),3978349). assertion_content_comment('tOboGo_NuclearCorticalMigration',s("The","symmetric","outward","movement","of","the","syncytial","nuclei","from","their","positions","in","the","ellipsoid","toward","the","periphery","of","the","embryo",",","during","mitotic","cycles","8","and","9",".","This","movement","results","in","the","placement","of","nuclei","in","a","uniform","monolayer","at","the","cortex","of","the","developing","embryo","."),4381947). assertion_content_comment('tOboGo_NuclearDicingBody',s("A","small","round","nuclear","body",",","measuring","0.2-0.8","microns","in","diameter","that","is","diffusely","distributed","throughout","the","nucleoplasm",".","Several","proteins","known","to","be","involved","in","miRNA","processing","have","been","localized","to","these","structures",".","D-bodies","are","thought","to","be","involved","in","primary-miRNA","processing","and/or","storage/assembly","of","miRNA","processing","complexes","."),4333375). assertion_content_comment('tOboGo_NuclearDivisionInvolvedInAppressoriumFormationOnOrNearHost',s("The","process","in","which","nuclear","division","occurs","within","a","symbiont","spore","that","contributes","to","appressorium","formation","on","or","near","the","exterior","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147136). assertion_content_comment('tOboGo_NuclearDivision',s("The","division","of","a","cell","nucleus","into","two","nuclei",",","with","DNA","and","other","nuclear","contents","distributed","between","the","daughter","nuclei","."),3970431). assertion_content_comment('tOboGo_NuclearDNAReplicationFactorCComplex',s("A","nuclear","complex","of","five","polypeptides","that","loads","the","DNA","polymerase","processivity","factor","proliferating","cell","nuclear","antigen","(","PCNA",")","onto","DNA",",","thereby","permitting","processive","DNA","synthesis","catalyzed","by","DNA","polymerase","delta","or","epsilon",".","In","Saccharomyces","and","several","other","species",",","the","subunits","are","known","as","Rfc1p-Rfc5p",",","although","subunit","names","do","not","necessarily","correspond","between","different","species","."),4094678). assertion_content_comment('tOboGo_NuclearEnvelopeDisassembly',s("The","controlled","breakdown","of","the","nuclear","envelope","in","the","context","of","a","normal","process","."),4012687). assertion_content_comment('tOboGo_NuclearEnvelopeLumen',s("The","region","between","the","two","lipid","bilayers","of","the","nuclear","envelope",";","20-40","nm","wide","."),4006572). assertion_content_comment('tOboGo_NuclearEnvelopeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","nuclear","envelope","."),4012669). assertion_content_comment('tOboGo_NuclearEnvelopeReassembly',s("The","reformation","of","the","nuclear","envelope","following","its","breakdown","in","the","context","of","a","normal","process","."),4012856). assertion_content_comment('tOboGo_NuclearEnvelope',s("The","double","lipid","bilayer","enclosing","the","nucleus","and","separating","its","contents","from","the","rest","of","the","cytoplasm",";","includes","the","intermembrane","space",",","a","gap","of","width","20-40","nm","(","also","called","the","perinuclear","space",")"),4006516). assertion_content_comment('tOboGo_NuclearEuchromatin',s("The","dispersed","less","dense","form","of","chromatin","in","the","interphase","nucleus",".","It","exists","in","at","least","two","forms",",","a","some","being","in","the","form","of","transcriptionally","active","chromatin","which","is","the","least","condensed",",","while","the","rest","is","inactive","euchromatin","which","is","more","condensed","than","active","chromatin","but","less","condensed","than","heterochromatin","."),4219717). assertion_content_comment('tOboGo_NuclearExosomeRNaseComplex',s("Complex","of","3","'","-5","'","exoribonucleases","found","in","the","nucleus","."),3972782). assertion_content_comment('tOboGo_NuclearExportSignalReceptorActivity',s("Combining","with","a","nuclear","export","signal","to","initiate","a","change","in","cell","activity","."),4215180). assertion_content_comment('tOboGo_NuclearExport',s("The","directed","movement","of","substances","out","of","the","nucleus","."),3970107). assertion_content_comment('tOboGo_NuclearFragmentationInvolvedInApoptoticNuclearChange',s("The","breakdown","of","the","nucleus","into","small","membrane-bounded","compartments",",","or","blebs",",","each","of","which","contain","compacted","DNA","."),4049102). assertion_content_comment('tOboGo_NuclearFusionDuringKaryogamy',s("OBSOLETE",".","The","fusion","of","two","haploid","nuclei","to","form","a","single","diploid","nucleus",",","as","seen","in","the","yeast","mating","process","."),4232338). assertion_content_comment('tOboGo_NuclearHeterochromatin',s("A","condensed","form","of","chromatin",",","occurring","in","the","nucleus","during","interphase",",","that","stains","strongly","with","basophilic","dyes",".","The","DNA","of","heterochromatin","is","typically","replicated","at","a","later","stage","in","the","cell-division","cycle","than","euchromatin","."),3985356). assertion_content_comment('tOboGo_NuclearHistoneMRNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","histone","messenger","RNA","(","mRNA",")","within","the","nucleus","."),4167249). assertion_content_comment('tOboGo_NuclearHormoneReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","nuclear","hormone","receptor",",","a","ligand-dependent","receptor","found","in","the","nucleus","of","the","cell","."),4277312). assertion_content_comment('tOboGo_NuclearImport',s("The","directed","movement","of","substances","into","the","nucleus","."),3970288). assertion_content_comment('tOboGo_NuclearInclusionBody',s("An","intranuclear","focus","at","which","aggregated","proteins","have","been","sequestered","."),4312306). assertion_content_comment('tOboGo_NuclearInnerMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","nuclear","inner","membrane","."),4169488). assertion_content_comment('tOboGo_NuclearInnerMembrane',s("The","inner",",","i.e",".","lumen-facing",",","lipid","bilayer","of","the","nuclear","envelope","."),4062251). assertion_content_comment('tOboGo_NuclearInterphaseChromosome',s("OBSOLETE",".","A","chromosome","found","in","the","nucleus","during","interphase","."),4346217). assertion_content_comment('tOboGo_NuclearLamina',s("The","fibrous",",","electron-dense","layer","lying","on","the","nucleoplasmic","side","of","the","inner","membrane","of","a","cell","nucleus",",","composed","of","lamin","filaments",".","The","polypeptides","of","the","lamina","are","thought","to","be","concerned","in","the","dissolution","of","the","nuclear","envelope","and","its","re-formation","during","mitosis",".","The","lamina","is","composed","of","lamin","A","and","lamin","C","filaments","cross-linked","into","an","orthogonal","lattice",",","which","is","attached","via","lamin","B","to","the","inner","nuclear","membrane","through","interactions","with","a","lamin","B","receptor",",","an","IFAP",",","in","the","membrane","."),4006605). assertion_content_comment('tOboGo_NuclearLocalizationSequenceBinding',s("Interacting","selectively","and","non-covalently","with","a","nuclear","localization","sequence",",","a","specific","peptide","sequence","that","acts","as","a","signal","to","localize","the","protein","within","the","nucleus","."),4246577). assertion_content_comment('tOboGo_NuclearLumen',s("The","volume","enclosed","by","the","nuclear","inner","membrane","."),3972757). assertion_content_comment('tOboGo_NuclearMatrixAnchoringAtNuclearMembrane',s("The","process","in","which","the","nuclear","matrix",",","the","dense","fibrillar","network","lying","on","the","inner","side","of","the","nuclear","membrane",",","is","directly","or","indirectly","linked","to","the","nuclear","membrane","."),4155457). assertion_content_comment('tOboGo_NuclearMatrixOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","nuclear","matrix",",","the","dense","fibrillar","network","lying","on","the","inner","side","of","the","nuclear","membrane","."),4155451). assertion_content_comment('tOboGo_NuclearMatrix',s("The","dense","fibrillar","network","lying","on","the","inner","side","of","the","nuclear","membrane","."),4034423). assertion_content_comment('tOboGo_NuclearMeioticCohesinComplex',s("A","cohesin","complex","that","mediates","sister","chromatid","cohesion","in","the","nucleus","during","meiosis",";","has","a","subunit","composition","distinct","from","that","of","the","meiotic","cohesin","complex","."),4348469). assertion_content_comment('tOboGo_NuclearMembraneFusionInvolvedInKaryogamy',s("The","joining","of","2","or","more","lipid","bilayer","membranes","that","surround","the","nucleus","during","the","creation","of","a","single","nucleus","from","multiple","nuclei","."),4103756). assertion_content_comment('tOboGo_NuclearMembraneFusion',s("The","joining","of","2","or","more","lipid","bilayer","membranes","that","surround","the","nucleus","."),4103753). assertion_content_comment('tOboGo_NuclearMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","nuclear","inner","or","outer","membrane","."),4049097). assertion_content_comment('tOboGo_NuclearMembranePart',s("Any","constituent","part","of","the","nuclear","membrane",",","the","envelope","that","surrounds","the","nucleus","of","eukaryotic","cells","."),4059328). assertion_content_comment('tOboGo_NuclearMembrane',s("Either","of","the","lipid","bilayers","that","surround","the","nucleus","and","form","the","nuclear","envelope",";","excludes","the","intermembrane","space","."),4007081). assertion_content_comment('tOboGo_NuclearMembraneVesicleBindingToChromatin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235232). assertion_content_comment('tOboGo_NuclearMicrotubule',s("Any","microtubule","in","the","nucleus","of","a","cell","."),4221509). assertion_content_comment('tOboGo_NuclearMigrationAlongMicrofilament',s("The","directed","movement","of","the","nucleus","along","microfilaments","within","the","cell",",","mediated","by","motor","proteins","."),4319154). assertion_content_comment('tOboGo_NuclearMigrationAlongMicrotubule',s("The","directed","movement","of","the","nucleus","along","microtubules","within","the","cell",",","mediated","by","motor","proteins","."),3977919). assertion_content_comment('tOboGo_NuclearMigrationInvolvedInConjugationWithCellularFusion',s("The","net","movement","of","nuclei","towards","one","another","as","a","prelude","to","karyogamy","in","organisms","undergoing","conjugation","with","cellular","fusion","."),3977933). assertion_content_comment('tOboGo_NuclearMigrationInvolvedInConjugationWithMutualGeneticExchange',s("The","net","movement","of","nuclei","towards","one","another",",","leading","to","the","bilateral","transfer","of","genetic","material","in","organisms","undergoing","conjugation","without","cellular","fusion","."),3977956). assertion_content_comment('tOboGo_NuclearMigration',s("The","directed","movement","of","the","nucleus","."),3977875). assertion_content_comment('tOboGo_NuclearMigrationToEmbryoSacPoles',s("Migration","of","the","nuclei","of","the","two-nucleate","embryo","sac","to","opposite","poles","of","the","cell","."),4346853). assertion_content_comment('tOboGo_NuclearMigrationToTheEmbryoSacCenter',s("Migration","of","one","of","the","four","nuclei","at","each","pole","of","the","eight-nucleate","embryo","sac",",","to","the","center","of","the","cell","."),4346837). assertion_content_comment('tOboGo_NuclearMIS12MINDTypeComplex',s("A","multiprotein","kinetochore","subcomplex","that","binds","to","centromeric","chromatin","and","forms","part","of","the","inner","kinetochore","of","a","chromosome","in","the","nucleus",".","It","helps","to","recruit","outer","kinetochore","subunits","that","will","bind","to","microtubules",".","Nuclear","localization","arises","in","some","organisms","because","the","nuclear","envelope","is","not","broken","down","during","mitosis",".","In","S",".","cerevisiae",",","it","consists","of","at","least","four","proteins",":","Mtw1p",",","Nnf1p",",","Nsl1p",",","and","Dsn1","."),3979089). assertion_content_comment('tOboGo_NuclearMitoticChromosome',s("OBSOLETE",".","A","chromosome","found","in","the","nucleus","during","mitosis","."),4346195). assertion_content_comment('tOboGo_NuclearMitoticCohesinComplex',s("A","cohesin","complex","that","mediates","sister","chromatid","cohesion","in","the","nucleus","during","mitosis",";","has","a","subunit","composition","distinct","from","that","of","the","meiotic","cohesin","complex","."),4348480). assertion_content_comment('tOboGo_NuclearMRNABranchSiteRecognition',s("Recognition","of","the","pre-mRNA","branch","site","sequence","by","components","of","the","assembling","spliceosome","."),3975395). assertion_content_comment('tOboGo_NuclearMRNACisSplicingViaSpliceosome',s("The","joining","together",",","after","removal","of","an","intervening","sequence","composed","of","one","or","more","introns",",","of","two","segments","of","the","same","RNA","molecule","via","spliceosomal","catalysis","to","produce","an","mRNA","composed","only","of","exon","sequences","that","all","came","from","the","same","primary","transcript","."),3974685). assertion_content_comment('tOboGo_NuclearMRNASplicingViaSpliceosome',s("The","joining","together","of","exons","from","one","or","more","primary","transcripts","of","nuclear","messenger","RNA","(","mRNA",")","and","the","excision","of","intron","sequences",",","via","a","spliceosomal","mechanism",",","so","that","mRNA","consisting","only","of","the","joined","exons","is","produced","."),3973565). assertion_content_comment('tOboGo_NuclearMRNASurveillanceOfMRNPExport',s("The","set","of","processes","involved","in","identifying","and","degrading","incorrectly","formed","or","aberrant","nuclear","mRNPs","docked","at","the","nuclear","pore","complex","prior","to","export","to","the","cytoplasm","."),4167357). assertion_content_comment('tOboGo_NuclearMRNASurveillance',s("The","set","of","processes","involved","in","identifying","and","degrading","defective","or","aberrant","mRNAs","within","the","nucleus","."),4128627). assertion_content_comment('tOboGo_NuclearMRNATransSplicingSLAddition',s("The","joining","together","of","two","independently","transcribed","RNAs",",","where","the","one","that","provides","the","5","'","portion","of","the","final","mRNA","is","from","a","splice","leader","RNA","(","SL-RNA",")","The","SL-RNA",",","or","mini-exon","donor","sequence",",","is","added","to","the","5","'","-end","of","the","acceptor","RNA","molecule","which","provides","the","mRNA","body","."),3974617). assertion_content_comment('tOboGo_NuclearMRNATransSplicingViaSpliceosome',s("The","joining","together","of","exons","from","two","different","primary","transcripts","of","messenger","RNA","(","mRNA",")","via","a","spliceosomal","mechanism",",","so","that","mRNA","consisting","only","of","the","joined","exons","is","produced","."),3974614). assertion_content_comment('tOboGo_NuclearNcRNASurveillance',s("The","set","of","processes","involved","in","identifying","and","degrading","defective","or","aberrant","ncRNAs","within","the","nucleus","."),4167216). assertion_content_comment('tOboGo_NuclearNucleosome',s("A","complex","comprised","of","DNA","wound","around","a","multisubunit","core","and","associated","proteins",",","which","forms","the","primary","packing","unit","of","DNA","in","the","nucleus","into","higher","order","structures","."),3978448). assertion_content_comment('tOboGo_NuclearOriginOfReplicationRecognitionComplex',s("A","multisubunit","complex","that","is","located","at","the","replication","origins","of","a","chromosome","in","the","nucleus","."),4220172). assertion_content_comment('tOboGo_NuclearOuterMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","nuclear","outer","membrane","."),4129340). assertion_content_comment('tOboGo_NuclearOuterMembrane',s("The","outer",",","i.e",".","cytoplasm-facing",",","lipid","bilayer","of","the","nuclear","envelope",";","continuous","with","the","endoplasmic","reticulum","of","the","cell","and","sometimes","studded","with","ribosomes","."),4007086). assertion_content_comment('tOboGo_NuclearPart',s("Any","constituent","part","of","the","nucleus",",","a","membrane-bounded","organelle","of","eukaryotic","cells","in","which","chromosomes","are","housed","and","replicated","."),3972724). assertion_content_comment('tOboGo_NuclearPeriphery',s("The","portion","of","the","nuclear","lumen","proximal","to","the","inner","nuclear","membrane","."),4006595). assertion_content_comment('tOboGo_NuclearPoreComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","nuclear","pore","complex","."),4012907). assertion_content_comment('tOboGo_NuclearPoreDistribution',s("Any","process","that","establishes","the","spatial","arrangement","of","nuclear","pores","within","the","nuclear","envelope","."),4319302). assertion_content_comment('tOboGo_NuclearPoreLocalization',s("Any","process","in","which","nuclear","pores","are","transported","to",",","or","maintained","in",",","a","specific","location","."),4285415). assertion_content_comment('tOboGo_NuclearPoreOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","nuclear","pore","."),4012884). assertion_content_comment('tOboGo_NuclearPore',s("Any","of","the","numerous","similar","discrete","openings","in","the","nuclear","envelope","of","a","eukaryotic","cell",",","where","the","inner","and","outer","nuclear","membranes","are","joined","."),4006544). assertion_content_comment('tOboGo_NuclearProteasomeComplex',s("A","proteasome","found","in","the","nucleus","of","a","cell","."),4060161). assertion_content_comment('tOboGo_NuclearProteasomeCoreComplex',s("The","core","complex","of","a","proteasome","located","in","the","nucleus","of","a","cell","."),4060251). assertion_content_comment('tOboGo_NuclearProteasomeRegulatoryParticleBaseSubcomplex',s("The","subunits","of","the","regulatory","particle","that","directly","associate","with","the","core","complex","of","a","proteasome","located","in","the","nucleus","of","a","cell","."),4060185). assertion_content_comment('tOboGo_NuclearProteasomeRegulatoryParticleLidSubcomplex',s("The","subunits","that","form","the","peripheral","lid","of","the","regulatory","particle","of","a","proteasome","located","in","the","nucleus","of","a","cell","."),4060174). assertion_content_comment('tOboGo_NuclearProteasomeRegulatoryParticle',s("The","regulatory","subcomplex","of","a","proteasome","located","in","the","nucleus","of","a","cell","."),4060163). assertion_content_comment('tOboGo_NuclearReplicationFork',s("The","Y-shaped","region","of","a","nuclear","replicating","DNA","molecule",",","resulting","from","the","separation","of","the","DNA","strands","and","in","which","the","synthesis","of","new","strands","takes","place",".","Also","includes","associated","protein","complexes","."),4006651). assertion_content_comment('tOboGo_NuclearReplisome',s("A","multi-component","enzymatic","machine","at","the","nuclear","replication","fork",",","which","mediates","DNA","replication",".","Includes","DNA","primase",",","one","or","more","DNA","polymerases",",","DNA","helicases",",","and","other","proteins","."),4006653). assertion_content_comment('tOboGo_NuclearRNAExportFactorComplex',s("A","protein","complex","that","contains","two","proteins","(","know","in","several","organisms",",","including","Drosophila",",","as","NXF1","and","NXF2",")","and","is","required","for","the","export","of","the","majority","of","mRNAs","from","the","nucleus","to","the","cytoplasm",";","localized","in","the","nucleoplasm","and","at","both","the","nucleoplasmic","and","cytoplasmic","faces","of","the","nuclear","pore","complex",";","shuttles","between","the","nucleus","and","the","cytoplasm","."),4314560). assertion_content_comment('tOboGo_NuclearRNASurveillance',s("The","set","of","processes","involved","in","identifying","and","degrading","defective","or","aberrant","RNAs","within","the","nucleus","."),4128623). assertion_content_comment('tOboGo_NuclearSCFUbiquitinLigaseComplex',s("A","ubiquitin","ligase","complex",",","located","in","the","nucleus",",","in","which","a","cullin","from","the","Cul1","subfamily","and","a","RING","domain","protein","form","the","catalytic","core",";","substrate","specificity","is","conferred","by","a","Skp1","adaptor","and","an","F-box","protein",".","SCF","complexes","are","involved","in","targeting","proteins","for","degradation","by","the","proteasome",".","The","best","characterized","complexes","are","those","from","yeast","and","mammals","(","with","core","subunits","named","Cdc53/Cul1",",","Rbx1/Hrt1/Roc1",")"),4318700). assertion_content_comment('tOboGo_NuclearSpeckOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","nuclear","specks",",","a","class","of","nuclear","body","in","which","splicing","factors","are","localized","."),4381787). assertion_content_comment('tOboGo_NuclearSpeck',s("A","discrete","extra-nucleolar","subnuclear","domain",",","20-50","in","number",",","in","which","splicing","factors","are","seen","to","be","localized","by","immunofluorescence","microscopy","."),4305914). assertion_content_comment('tOboGo_NuclearTelomereCapComplex',s("A","complex","of","DNA","and","protein","located","at","the","end","of","a","linear","chromosome","in","the","nucleus","that","protects","and","stabilizes","a","linear","chromosome","."),3978519). assertion_content_comment('tOboGo_NuclearTelomericHeterochromatin',s("Heterochromatic","regions","of","the","chromosome","found","at","the","telomeres","of","a","chromosome","in","the","nucleus","."),4008011). assertion_content_comment('tOboGo_NuclearTranslocationOfHog1',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235588). assertion_content_comment('tOboGo_NuclearTranslocationOfMAPKDuringSporulationSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310042). assertion_content_comment('tOboGo_NuclearTranslocationOfMAPKDuringSporulationSensuSaccharomyces',s("OBSOLETE",".","Movement","of","a","MAP","kinase","to","the","nucleus","in","the","context","of","sporulation",".","As","in",",","but","not","restricted","to",",","the","taxon","Saccharomyces","(","Saccharomyces",",","ncbi_taxonomy_id",":","4930",")"),4346464). assertion_content_comment('tOboGo_NuclearTranslocationOfMAPKMatingSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310439). assertion_content_comment('tOboGo_NuclearTranslocationOfMAPKMatingSensuSaccharomyces',s("OBSOLETE",".","Movement","of","a","MAP","kinase","to","the","nucleus","in","the","context","of","transduction","of","mating","pheromone","signal",",","as","described","for","Saccharomyces","."),4235609). assertion_content_comment('tOboGo_NuclearTranslocationOfMAPKPseudohyphalGrowth',s("OBSOLETE",".","Movement","of","a","MAP","kinase","to","the","nucleus","in","the","context","of","regulating","pseudohyphal","or","invasive","growth","."),4345936). assertion_content_comment('tOboGo_NuclearTransport',s("The","directed","movement","of","substances","into",",","out","of",",","or","within","the","nucleus","."),3970101). assertion_content_comment('tOboGo_NuclearUbiquitinLigaseComplex',s("A","ubiquitin","ligase","complex","found","in","the","nucleus","."),4220469). assertion_content_comment('tOboGo_NucleaseActivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","nucleic","acids","."),4174694). assertion_content_comment('tOboGo_NucleateErythrocyteDevelopment',s("The","process","aimed","at","the","progression","of","a","nucleate","erythrocyte","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4095422). assertion_content_comment('tOboGo_NucleateErythrocyteDifferentiation',s("The","process","in","which","a","myeloid","precursor","cell","acquires","specializes","features","of","an","erythrocyte","with","a","nucleus",",","as","found","in","non-mammalian","vertebrates","such","as","birds","."),4095418). assertion_content_comment('tOboGo_NucleateErythrocyteMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","nucleate","erythrocyte","to","attain","its","fully","functional","state",".","A","nucleate","erythrocyte","is","an","erythrocyte","with","a","nucleus","."),4095434). assertion_content_comment('tOboGo_NucleicAcidBinding',s("Interacting","selectively","and","non-covalently","with","any","nucleic","acid","."),3975006). assertion_content_comment('tOboGo_NucleicAcidBindingTranscriptionFactorActivity',s("Interacting","selectively","and","non-covalently","with","a","DNA","or","RNA","sequence","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","a","protein","or","macromolecular","complex","."),4192835). assertion_content_comment('tOboGo_NucleicAcidMetabolicProcess',s("Any","cellular","metabolic","process","involving","nucleic","acids","."),3969031). assertion_content_comment('tOboGo_NucleicAcidPhosphodiesterBondHydrolysis',s("The","nucleic","acid","metabolic","process","in","which","the","phosphodiester","bonds","between","nucleotides","are","cleaved","by","hydrolysis","."),3976058). assertion_content_comment('tOboGo_NucleicAcid',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218294). assertion_content_comment('tOboGo_NucleicAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nucleic","acids","from","one","side","of","a","membrane","to","the","other",".","Nucleic","acids","are","single","or","double-stranded","polynucleotides","involved","in","the","storage",",","transmission","and","transfer","of","genetic","information","."),4286908). assertion_content_comment('tOboGo_NucleicAcidTransport',s("The","directed","movement","of","nucleic","acids",",","single","or","double-stranded","polynucleotides","involved","in","the","storage",",","transmission","and","transfer","of","genetic","information",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4009490). assertion_content_comment('tOboGo_NucleobaseBinding',s("Interacting","selectively","and","non-covalently","with","a","nucleobase",",","any","of","a","class","of","pyrmidines","or","purines",",","organic","nitrogenous","bases","."),4373645). assertion_content_comment('tOboGo_NucleobaseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","nucleobase",",","a","nitrogenous","base","that","is","a","constituent","of","a","nucleic","acid","."),4226716). assertion_content_comment('tOboGo_NucleobaseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","nucleobase",",","a","nitrogenous","base","that","is","a","constituent","of","a","nucleic","acid","."),4226309). assertion_content_comment('tOboGo_Nucleobase_CationSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","nucleobase","(","out",")","+","cation","(","out",")","=","nucleobase","(","in",")","+","cation","(","in",")"),4215802). assertion_content_comment('tOboGo_NucleobaseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","nucleobase",",","a","nitrogenous","base","that","is","a","constituent","of","a","nucleic","acid",",","e.g",".","the","purines",":","adenine",",","guanine",",","hypoxanthine",",","xanthine","and","the","pyrimidines",":","cytosine",",","uracil",",","thymine","."),4010755). assertion_content_comment('tOboGo_NucleobaseNucleosideAndNucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nucleobases",",","nucleosides","and","nucleotides","."),4027575). assertion_content_comment('tOboGo_NucleobaseNucleosideAndNucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nucleobases",",","nucleosides","and","nucleotides","."),4005148). assertion_content_comment('tOboGo_NucleobaseNucleosideAndNucleotideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","nucleobase",",","nucleoside","or","nucleotide","is","synthesized","from","another","nucleobase",",","nucleoside","or","nucleotide","."),4244601). assertion_content_comment('tOboGo_NucleobaseNucleosideAndNucleotideMetabolicProcess',s("The","cellular","chemical","reactions","and","pathways","involving","nucleobases",",","nucleosides","and","nucleotides","."),4005060). assertion_content_comment('tOboGo_NucleobaseNucleosideNucleotideAndNucleicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids","."),4027567). assertion_content_comment('tOboGo_NucleobaseNucleosideNucleotideAndNucleicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids","."),4005141). assertion_content_comment('tOboGo_NucleobaseNucleosideNucleotideAndNucleicAcidMetabolicProcess',s("Any","cellular","metabolic","process","involving","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids","."),3969026). assertion_content_comment('tOboGo_NucleobaseNucleosideNucleotideAndNucleicAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids","from","one","side","of","a","membrane","to","the","other","."),4166885). assertion_content_comment('tOboGo_NucleobaseNucleosideNucleotideAndNucleicAcidTransport',s("The","directed","movement","of","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4009488). assertion_content_comment('tOboGo_NucleobaseNucleosideNucleotideKinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP","or","GTP",",","to","a","nucleobase",",","nucleoside",",","nucleotide","or","polynucleotide","substrate","."),4199480). assertion_content_comment('tOboGo_NucleobaseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","nucleobase",",","any","nitrogenous","base","that","is","a","constituent","of","a","nucleoside",",","nucleotide",",","or","nucleic","acidfrom","one","side","of","a","membrane","to","the","other","."),4215799). assertion_content_comment('tOboGo_NucleobaseTransport',s("The","directed","movement","of","a","nucleobase",",","any","nitrogenous","base","that","is","a","constituent","of","a","nucleoside",",","nucleotide",",","or","nucleic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083307). assertion_content_comment('tOboGo_NucleocytoplasmicShuttlingComplex',s("Any","complex","that","acts","to","move","proteins","or","RNAs","into","or","out","of","the","nucleus","through","nuclear","pores","."),4316627). assertion_content_comment('tOboGo_NucleocytoplasmicTransporterActivity',s("Enables","the","directed","movement","of","substances","between","the","nucleus","and","the","cytoplasm","of","a","cell","."),4219349). assertion_content_comment('tOboGo_NucleocytoplasmicTransport',s("The","directed","movement","of","molecules","between","the","nucleus","and","the","cytoplasm","."),3970104). assertion_content_comment('tOboGo_NucleoidOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","nucleoid",".","The","nucleoid","is","the","region","of","a","bacterial","cell",",","mitochondrion","or","chloroplast","to","which","the","DNA","is","confined","."),4149160). assertion_content_comment('tOboGo_Nucleoid',s("The","region","of","a","bacterial","cell",",","mitochondrion","or","chloroplast","to","which","the","DNA","is","confined","."),3973855). assertion_content_comment('tOboGo_NucleokinesisInvolvedInCellMotilityInCerebralCortexRadialGliaGuidedMigration',s("The","microtubule-mediated","movement","of","the","nucleus","that","is","required","for","the","movement","of","cells","along","radial","glial","fibers","as","a","component","of","the","process","of","cerebral","cortex","glial-mediated","radial","cell","migration","."),4049990). assertion_content_comment('tOboGo_NucleolarChromatin',s("The","portion","of","nuclear","chromatin","associated","with","the","nucleolus",";","includes","the","DNA","encoding","the","ribosomal","RNA","."),4061851). assertion_content_comment('tOboGo_NucleolarFragmentationInvolvedInReplicativeAging',s("A","nucleolar","fragmentation","process","that","gives","rise","to","multiple","rounded","structures","and","that","occurs","in","conjunction","with","increasing","age","in","dividing","cells","."),3979855). assertion_content_comment('tOboGo_NucleolarFragmentation',s("The","cell","aging","process","that","results","in","the","nucleolus","breaking","down","into","fragments","."),3979851). assertion_content_comment('tOboGo_NucleolarPart',s("Any","constituent","part","of","a","nucleolus",",","a","small",",","dense","body","one","or","more","of","which","are","present","in","the","nucleus","of","eukaryotic","cells",".","It","is","rich","in","RNA","and","protein",",","is","not","bounded","by","a","limiting","membrane",",","and","is","not","seen","during","mitosis","."),4051910). assertion_content_comment('tOboGo_NucleolarPreribosome',s("Any","complex","of","pre-rRNAs",",","ribosomal","proteins",",","and","associated","proteins","formed","in","the","nucleolus","during","ribosome","biogenesis","."),4308313). assertion_content_comment('tOboGo_NucleolarRibonucleasePComplex',s("A","ribonuclease","P","complex","located","in","the","nucleolus","of","a","eukaryotic","cell",",","where","it","catalyzes","the","5","'","endonucleolytic","cleavage","of","precursor","tRNAs","to","yield","mature","tRNAs",".","Eukaryotic","nucleolar","ribonuclease","P","complexes","generally","contain","a","single","RNA","molecule","that","is","necessary","but","not","sufficient","for","catalysis",",","and","several","protein","molecules","."),4220222). assertion_content_comment('tOboGo_NucleolarSizeIncreaseSensuSaccharomyces',s("OBSOLETE",".","The","process","of","nucleolar","expansion",",","as","seen","in","Saccharomyces","."),4360026). assertion_content_comment('tOboGo_NucleolarSizeIncrease',s("OBSOLETE",".","The","process","of","nucleolar","expansion","."),4234822). assertion_content_comment('tOboGo_Nucleologenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","nucleolus",",","a","small",",","dense","body","one","or","more","of","which","are","present","in","the","nucleus","of","eukaryotic","cells","."),4267508). assertion_content_comment('tOboGo_NucleolusOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","the","nucleolus","."),3979846). assertion_content_comment('tOboGo_NucleolusOrganizerRegion',s("A","region","of","a","chromosome","where","nucleoli","form","during","interphase",",","and","where","genes","encoding","the","largest","rRNA","precursor","transcript","are","tandemly","arrayed","."),4219833). assertion_content_comment('tOboGo_Nucleolus',s("A","small",",","dense","body","one","or","more","of","which","are","present","in","the","nucleus","of","eukaryotic","cells",".","It","is","rich","in","RNA","and","protein",",","is","not","bounded","by","a","limiting","membrane",",","and","is","not","seen","during","mitosis",".","Its","prime","function","is","the","transcription","of","the","nucleolar","DNA","into","45S","ribosomal-precursor","RNA",",","the","processing","of","this","RNA","into","5.8S",",","18S",",","and","28S","components","of","ribosomal","RNA",",","and","the","association","of","these","components","with","5S","RNA","and","proteins","synthesized","outside","the","nucleolus",".","This","association","results","in","the","formation","of","ribonucleoprotein","precursors",";","these","pass","into","the","cytoplasm","and","mature","into","the","40S","and","60S","subunits","of","the","ribosome","."),4007969). assertion_content_comment('tOboGo_NucleolusToNucleoplasmTransport',s("The","directed","movement","of","substances","from","the","nucleolus","to","the","nucleoplasm","."),4330472). assertion_content_comment('tOboGo_Nucleomorph',s("A","small",",","vestigial","nucleus","found","in","some","plastids","that","derive","from","a","eukaryotic","endosymbiont",".","Observed","in","chlorarachniophytes","and","cryptomonads",",","which","acquired","their","plastids","from","a","green","and","red","alga","respectively","."),4347554). assertion_content_comment('tOboGo_NucleoplasmicReticulum',s("Long",",","dynamic","tubular","channels",",","formed","by","invagination","of","the","nuclear","envelope",",","that","extend","deep","into","the","nucleoplasm",".","The","channels","have","an","underlying","lamina","and","are","implicated","in","functioning","in","signaling","and","transport","."),4097395). assertion_content_comment('tOboGo_NucleoplasmicTHOComplex',s("The","THO","complex","when","it","is","acting","as","a","nuclear","complex","that","is","required","for","transcription","elongation","through","genes","containing","tandemly","repeated","DNA","sequences",".","In","S",".","cerevisiae",",","it","is","composed","of","four","subunits",":","Hpr1",",","Tho2",",","Thp1",",","and","Mft1",",","while","the","human","complex","is","composed","of","7","subunits","."),4362464). assertion_content_comment('tOboGo_NucleoplasminATPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",".","The","hydrolysis","of","ATP","required","for","the","ATP-dependent","assembly","of","nucleosome","cores",",","in","decondensation","of","sperm","chromatin","and","in","other","histone-involving","processes","."),4252605). assertion_content_comment('tOboGo_NucleoplasmPart',s("Any","constituent","part","of","the","nucleoplasm",",","that","part","of","the","nuclear","content","other","than","the","chromosomes","or","the","nucleolus","."),3976511). assertion_content_comment('tOboGo_Nucleoplasm',s("That","part","of","the","nuclear","content","other","than","the","chromosomes","or","the","nucleolus","."),3976509). assertion_content_comment('tOboGo_NucleosideBinding',s("Interacting","selectively","and","non-covalently","with","a","nucleoside",",","a","compound","consisting","of","a","purine","or","pyrimidine","nitrogenous","base","linked","either","to","ribose","or","deoxyribose","."),4331252). assertion_content_comment('tOboGo_NucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","one","of","a","family","of","organic","molecules","consisting","of","a","purine","or","pyrimidine","base","covalently","bonded","to","a","sugar","ribose","(","a","ribonucleoside",")","or","deoxyribose","(","a","deoxyribonucleoside",")"),4171745). assertion_content_comment('tOboGo_NucleosideBisphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","nucleoside","bisphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4266699). assertion_content_comment('tOboGo_NucleosideBisphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","nucleoside","bisphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4343638). assertion_content_comment('tOboGo_NucleosideBisphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","nucleoside","bisphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4148814). assertion_content_comment('tOboGo_NucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","one","of","a","family","of","organic","molecules","consisting","of","a","purine","or","pyrimidine","base","covalently","bonded","to","a","sugar","ribose","(","a","ribonucleoside",")","or","deoxyribose","(","a","deoxyribonucleoside",")"),4176914). assertion_content_comment('tOboGo_NucleosideDeoxyribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-deoxy-D-ribosyl-base1","+","base2","=","2-deoxy-D-ribosyl-base2","+","base1","."),4271516). assertion_content_comment('tOboGo_NucleosideDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","nucleoside","diphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4222984). assertion_content_comment('tOboGo_NucleosideDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","nucleoside","diphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223126). assertion_content_comment('tOboGo_NucleosideDiphosphateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","nucleoside","diphosphate","=","ADP","+","nucleoside","triphosphate","."),4204754). assertion_content_comment('tOboGo_NucleosideDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","nucleoside","diphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4222980). assertion_content_comment('tOboGo_NucleosideDiphosphatePhosphorylation',s("The","process","of","introducing","a","phosphate","group","into","a","nucleoside","diphosphate","to","produce","a","nucleoside","triphosphate","."),4227093). assertion_content_comment('tOboGo_Nucleoside_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","nucleoside","(","out",")","+","H","+","(","out",")","=","nucleoside","(","in",")","+","H","+","(","in",")"),4292723). assertion_content_comment('tOboGo_NucleosideKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","nucleoside","=","ADP","+","nucleoside","monophosphate","."),4199482). assertion_content_comment('tOboGo_NucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","nucleoside",",","a","nucleobase","linked","to","either","beta-D-ribofuranose","(","a","ribonucleoside",")","or","2-deoxy-beta-D-ribofuranose",",","(","a","deoxyribonucleoside",")",",","e.g",".","adenosine",",","guanosine",",","inosine",",","cytidine",",","uridine","and","deoxyadenosine",",","deoxyguanosine",",","deoxycytidine","and","thymidine","(","=","deoxythymidine",")"),4024209). assertion_content_comment('tOboGo_NucleosideMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","nucleoside","monophosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4027611). assertion_content_comment('tOboGo_NucleosideMonophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","nucleoside","monophosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4050054). assertion_content_comment('tOboGo_NucleosideMonophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","nucleoside","monophosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4027522). assertion_content_comment('tOboGo_NucleosideMonophosphatePhosphorylation',s("The","process","of","introducing","one","or","more","phosphate","groups","into","a","nucleoside","monophosphate","to","produce","a","polyphosphorylated","nucleoside","."),4229296). assertion_content_comment('tOboGo_NucleosideOxidaseActivity',s("Catalysis","of","the","reactions",":","inosine","+","O2","=","9-riburonosylhypoxanthine","+","2","H2O",";","(","1a",")","2","inosine","+","O2","=","2","5","'","-dehydroinosine","+","2","H2O",",","and","(","1b",")","2","5","'","-dehydroinosine","+","O2","=","2","9-riburonosylhypoxanthine","+","2","H2O","."),4341956). assertion_content_comment('tOboGo_NucleosidePhosphateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","nucleoside","phosphate","=","ADP","+","nucleoside","diphosphate","."),4271450). assertion_content_comment('tOboGo_NucleosidePhosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","phosphorylated","nucleoside","."),4005063). assertion_content_comment('tOboGo_NucleosidePhosphoacylhydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","mixed","phospho-anhydride","bonds","."),4345034). assertion_content_comment('tOboGo_NucleosidePhosphotransferaseActivity',s("Catalysis","of","the","reaction",":","a","nucleotide","+","a","2","'","-deoxynucleoside","=","a","nucleoside","+","a","2","'","-deoxynucleoside","5","'","-monophosphate","."),4271436). assertion_content_comment('tOboGo_NucleosideRibosyltransferaseActivity',s("Catalysis","of","the","reaction",":","D-ribosyl-base1","+","base2","=","D-ribosyl-base2","+","base1","."),4271424). assertion_content_comment('tOboGo_NucleosideSalvage',s("Any","process","which","produces","a","nucleotide",",","a","nucleobase","linked","to","either","beta-D-ribofuranose","(","ribonucleoside",")","or","2-deoxy-beta-D-ribofuranose","(","a","deoxyribonucleotide",")",",","from","derivatives","of","it","without","de","novo","synthesis","."),4225942). assertion_content_comment('tOboGo_Nucleoside_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","nucleoside","(","out",")","+","Na","+","(","out",")","=","nucleoside","(","in",")","+","Na","+","(","in",")"),4219642). assertion_content_comment('tOboGo_NucleosideTransmembraneTransporterActivityAgainstAConcentrationGradient',s("Catalysis","of","the","transfer","of","a","nucleoside",",","from","one","side","of","a","membrane","to","the","other",",","up","a","concentration","gradient","."),4334180). assertion_content_comment('tOboGo_NucleosideTransmembraneTransporterActivityDownAConcentrationGradient',s("Catalysis","of","the","transfer","of","a","nucleoside",",","from","one","side","of","a","membrane","to","the","other",",","down","the","concentration","gradient","."),4295711). assertion_content_comment('tOboGo_NucleosideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","nucleoside",",","a","nucleobase","linked","to","either","beta-D-ribofuranose","(","ribonucleoside",")","or","2-deoxy-beta-D-ribofuranose",",","(","a","deoxyribonucleotide",")","from","one","side","of","a","membrane","to","the","other","."),4166887). assertion_content_comment('tOboGo_NucleosideTransport',s("The","directed","movement","of","a","nucleoside",",","a","nucleobase","linked","to","either","beta-D-ribofuranose","(","ribonucleoside",")","or","2-deoxy-beta-D-ribofuranose",",","(","a","deoxyribonucleotide",")",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053741). assertion_content_comment('tOboGo_NucleosideTriphosphateAdenylateKinaseActivity',s("Catalysis","of","the","reaction",":","nucleoside","triphosphate","+","AMP","=","nucleoside","diphosphate","+","ADP","."),4357211). assertion_content_comment('tOboGo_NucleosideTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","nucleoside","triphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222646). assertion_content_comment('tOboGo_NucleosideTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","nucleoside","triphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4005214). assertion_content_comment('tOboGo_NucleosideTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","nucleoside","triphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4005210). assertion_content_comment('tOboGo_NucleosomalDNABinding',s("Interacting","selectively","and","non-covalently","with","the","DNA","portion","of","a","nucleosome","."),4321712). assertion_content_comment('tOboGo_NucleosomalHistoneBinding',s("Interacting","selectively","and","non-covalently","with","a","histone","that","is","assembled","into","a","nucleosome","."),4321722). assertion_content_comment('tOboGo_NucleosomalMethylationActivatorComplex',s("A","protein","complex","that","contains","eight","subunits","in","common","with","the","SWI/SNF","complex",",","plus","the","ATPase","BRG1","(","SMARCA4",")","and","the","histone","methyltransferase","CARM1",";","the","complex","is","involved","in","regulating","nuclear","receptor-dependent","transcription","."),4172929). assertion_content_comment('tOboGo_NucleosomeAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","nucleosome",",","the","beadlike","structural","units","of","eukaryotic","chromatin","composed","of","histones","and","DNA","."),4011161). assertion_content_comment('tOboGo_NucleosomeBinding',s("Interacting","selectively","and","non-covalently","with","a","nucleosome",",","a","complex","comprised","of","DNA","wound","around","a","multisubunit","core","and","associated","proteins",",","which","forms","the","primary","packing","unit","of","DNA","into","higher","order","structures","."),4074159). assertion_content_comment('tOboGo_NucleosomeDisassembly',s("The","controlled","breakdown","of","nucleosomes",",","the","beadlike","structural","units","of","eukaryotic","chromatin","composed","of","histones","and","DNA","."),4011125). assertion_content_comment('tOboGo_NucleosomeMobilization',s("The","movement","of","nucleosomes","along","a","DNA","fragment","."),4317154). assertion_content_comment('tOboGo_NucleosomeModeling',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4305538). assertion_content_comment('tOboGo_NucleosomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","one","or","more","nucleosomes","."),4011121). assertion_content_comment('tOboGo_NucleosomePositioning',s("Ordering","of","successions","of","nucleosomes","into","regular","arrays","so","that","nucleosomes","are","positioned","at","defined","distances","from","one","another","."),4305526). assertion_content_comment('tOboGo_Nucleosome',s("A","complex","comprised","of","DNA","wound","around","a","multisubunit","core","and","associated","proteins",",","which","forms","the","primary","packing","unit","of","DNA","into","higher","order","structures","."),3978444). assertion_content_comment('tOboGo_NucleotidaseActivity',s("Catalysis","of","the","reaction",":","a","nucleotide","+","H2O","=","a","nucleoside","+","phosphate","."),4253797). assertion_content_comment('tOboGo_NucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","nucleotide",",","any","compound","consisting","of","a","nucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","ribose","or","deoxyribose","."),4175588). assertion_content_comment('tOboGo_NucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nucleotides",",","any","nucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","glycose","moiety",";","may","be","mono-",",","di-","or","triphosphate",";","this","definition","includes","cyclic-nucleotides","(","nucleoside","cyclic","phosphates",")"),4027581). assertion_content_comment('tOboGo_NucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nucleotides",",","any","nucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","glycose","moiety",";","may","be","mono-",",","di-","or","triphosphate",";","this","definition","includes","cyclic-nucleotides","(","nucleoside","cyclic","phosphates",")"),4005153). assertion_content_comment('tOboGo_NucleotideDiphosphataseActivity',s("Catalysis","of","the","reaction",":","a","dinucleotide","+","H2O","=","2","mononucleotides","."),4204729). assertion_content_comment('tOboGo_NucleotideDiphosphokinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","nucleoside","5","'","-phosphate","=","AMP","+","5","'","-phosphonucleoside","3","'","-diphosphate","."),4271410). assertion_content_comment('tOboGo_NucleotideKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","nucleoside","monophosphate","=","ADP","+","nucleoside","diphosphate","."),4202121). assertion_content_comment('tOboGo_NucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","nucleotide",",","a","nucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","glycose","moiety",";","may","be","mono-",",","di-","or","triphosphate",";","this","definition","includes","cyclic","nucleotides","(","nucleoside","cyclic","phosphates",")"),4005066). assertion_content_comment('tOboGo_NucleotidePhosphataseActivity',s("Catalysis","of","the","reaction",":","phosphopolynucleotide","+","H2O","=","polynucleotide","+","phosphate","."),4203384). assertion_content_comment('tOboGo_NucleotidePhosphorylation',s("The","process","of","introducing","one","or","more","phosphate","groups","into","a","nucleotide","to","produce","a","phosphorylated","nucleoside","."),4227091). assertion_content_comment('tOboGo_NucleotideReceptorActivity',s("Combining","with","a","nucleotide","to","initiate","a","change","in","cell","activity",".","A","nucleotide","is","a","compound","that","consists","of","a","nucleoside","esterified","with","a","phosphate","molecule","."),4171651). assertion_content_comment('tOboGo_NucleotideSalvage',s("Any","process","which","produces","a","nucleotide",",","a","compound","consisting","of","a","nucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","glycose","moiety",",","from","derivatives","of","it","without","de","novo","synthesis","."),4225845). assertion_content_comment('tOboGo_NucleotideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","nucleotide",",","any","compound","consisting","of","a","nucleoside","that","is","esterified","with","(","ortho",")","phosphate",",","from","one","side","of","a","membrane","to","the","other","."),4181582). assertion_content_comment('tOboGo_NucleotideTransport',s("The","directed","movement","of","a","nucleotide",",","any","compound","consisting","of","a","nucleoside","that","is","esterified","with","(","ortho",")","phosphate",",","into",",","out","of","or","within","a","cell","."),4176250). assertion_content_comment('tOboGo_NucleotidyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","nucleotidyl","group","to","a","reactant","."),3974934). assertion_content_comment('tOboGo_NucleusAccumbensDevelopment',s("The","progression","of","the","nucleus","accumbens","over","time","from","its","initial","formation","until","its","mature","state",".","The","nucleus","accumbens","is","a","collection","of","pleomorphic","cells","in","the","caudal","part","of","the","anterior","horn","of","the","lateral","ventricle",",","in","the","region","of","the","olfactory","tubercle",",","lying","between","the","head","of","the","caudate","nucleus","and","the","anterior","perforated","substance",".","It","is","part","of","the","ventral","striatum",",","a","composite","structure","considered","part","of","the","basal","ganglia","."),4049319). assertion_content_comment('tOboGo_NucleusAmbiguusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","nucleus","ambiguus","over","time",",","from","its","formation","to","the","mature","structure","."),4042765). assertion_content_comment('tOboGo_NucleusInheritance',s("The","partitioning","of","nuclei","between","daughter","cells","at","cell","division","."),4334591). assertion_content_comment('tOboGo_NucleusLocalization',s("Any","process","in","which","the","nucleus","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell","."),3977860). assertion_content_comment('tOboGo_NucleusOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","nucleus","."),3977789). assertion_content_comment('tOboGo_Nucleus',s("A","membrane-bounded","organelle","of","eukaryotic","cells","in","which","chromosomes","are","housed","and","replicated",".","In","most","cells",",","the","nucleus","contains","all","of","the","cell","'","s","chromosomes","except","the","organellar","chromosomes",",","and","is","the","site","of","RNA","synthesis","and","processing",".","In","some","species",",","or","in","specialized","cell","types",",","RNA","metabolism","or","DNA","replication","may","be","absent","."),3972721). assertion_content_comment('tOboGo_Number16_0MonogalactosyldiacylglycerolDesaturaseActivity',s("Catalysis","of","the","introduction","of","an","omega-3","double","bond","into","an","unsaturated","16-carbon","fatty","acid","in","a","monogalactosyldiacylglycerol","molecule","."),4262017). assertion_content_comment('tOboGo_Number26SProteasome',s("OBSOLETE",".","A","large","multisubunit","protease","found","in","the","cytosol","that","recognizes",",","unfolds",",","and","digests","protein","substrates","that","have","been","marked","for","degradation","by","the","attachment","of","a","ubiquitin","group",".","Individual","subcomplexes","of","the","complete","26S","proteasome","are","involved","in","these","different","tasks",":","the","ATP-dependent","19S","caps","are","believed","to","unfold","substrates","and","feed","them","to","the","actual","protease",",","the","20S","proteasome","."),4221673). assertion_content_comment('tOboGo_Number2Iron2SulfurClusterBinding',s("Interacting","selectively","and","non-covalently","with","a","2","iron",",","2","sulfur","(","2Fe-2S",")","cluster",";","this","cluster","consists","of","two","iron","atoms",",","with","two","inorganic","sulfur","atoms","found","between","the","irons","and","acting","as","bridging","ligands","."),4283741). assertion_content_comment('tOboGo_Number3Iron4SulfurClusterBinding',s("Interacting","selectively","and","non-covalently","with","a","3","iron",",","4","sulfur","(","3Fe-4S",")","cluster",";","this","cluster","consists","of","three","iron","atoms",",","with","the","inorganic","sulfur","atoms","found","between","the","irons","and","acting","as","bridging","ligands",".","It","is","essentially","a","4Fe-4S","cluster","with","one","iron","missing","."),4283757). assertion_content_comment('tOboGo_Number4Iron4SulfurClusterBinding',s("Interacting","selectively","and","non-covalently","with","a","4","iron",",","4","sulfur","(","4Fe-4S",")","cluster",";","this","cluster","consists","of","four","iron","atoms",",","with","the","inorganic","sulfur","atoms","found","between","the","irons","and","acting","as","bridging","ligands","."),4283773). assertion_content_comment('tOboGo_Number5SClassRRNATranscriptionFromRNAPolymeraseIIIType1Promoter',s("The","synthesis","of","5S","ribosomal","RNA","(","rRNA",")",",","or","an","equivalent","rRNA",",","from","a","DNA","template","by","RNA","polymerase","III","(","Pol","III",")",",","originating","at","a","type","1","RNA","polymerase","III","promoter","."),3979160). assertion_content_comment('tOboGo_Number5SRDNABinding',s("Interacting","selectively","and","non-covalently","with","the","5S","rDNA","sequence","encoding","ribosomal","5S","rRNA",",","which","is","individually","transcribed","by","RNA","polymerase","III",",","rather","than","by","RNA","polymerase","I",",","in","species","where","it","exists","."),4182407). assertion_content_comment('tOboGo_Number5SRRNABinding',s("Interacting","selectively","and","non-covalently","with","5S","ribosomal","RNA",",","the","smallest","RNA","constituent","of","a","ribosome","."),4247075). assertion_content_comment('tOboGo_Number5SRRNAPrimaryTranscriptBinding',s("Interacting","selectively","and","non-covalently","with","the","unprocessed","5S","ribosomal","RNA","transcript","."),4247113). assertion_content_comment('tOboGo_Number7SRNABinding',s("Interacting","selectively","and","non-covalently","with","7S","RNA",",","the","RNA","component","of","the","signal","recognition","particle","(","SRP",")"),4255472). assertion_content_comment('tOboGo_Number90SPreribosomeAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","RNA","molecules","to","form","a","90S","preribosome","."),4074973). assertion_content_comment('tOboGo_Number90SPreribosome',s("A","large","ribonucleoprotein","complex","considered","to","be","the","earliest","preribosomal","complex",".","In","S",".","cerevisiae",",","it","has","a","size","of","90S","and","consists","of","the","35S","pre-rRNA",",","early-associating","ribosomal","proteins","most","of","which","are","part","of","the","small","ribosomal","subunit",",","the","U3","snoRNA","and","associated","proteins","."),4051921). assertion_content_comment('tOboGo_Nup82Complex',s("A","protein","complex","that","forms","part","of","the","nuclear","pore","complex",".","It","forms","a","subcomplex","with","Nup159p","and","Nsp1p",",","interacts","with","Nup116p",",","and","is","required","for","proper","localization","of","Nup116p",".","In","Saccharomyces","cerevisiae","this","complex","contains","Nup82p",",","Nsp1p",",","Nup159p",",","Nup116p",",","and","Gle2p","."),4109589). assertion_content_comment('tOboGo_NuRDComplex',s("An","approximately","2","MDa","multi-subunit","complex","that","exhibits","ATP-dependent","chromatin","remodeling","activity","in","addition","to","histone","deacetylase","(","HDAC",")","activity",",","and","has","been","shown","to","establish","transcriptional","repression","of","a","number","of","target","genes","in","vertebrates",",","invertebrates","and","fungi",".","Amongst","its","subunits",",","the","NuRD","complex","contains","histone","deacetylases",",","histone","binding","proteins","and","Mi-2-like","proteins","."),4305575). assertion_content_comment('tOboGo_NURFComplex',s("A","four","subunit","ISWI-containing","protein","complex","that","facilitates","nucleosome","mobility","and","transcriptional","activation","in","an","ATP-dependent","manner",".","In","contrast","to","other","chromatin","remodeling","complexes",",","the","ATPase","activity","of","NURF","requires","nucleosomes","rather","than","free","DNA","or","histones","."),4305605). assertion_content_comment('tOboGo_NurseCellApoptosis',s("The","process","in","which","nurse","cells","undergo","apoptosis",".","During","late","oogenesis",",","following","the","transfer","of","substances","from","the","nurse","cells","to","the","oocyte",",","nurse","cell","remnants","are","cleared","from","the","egg","chamber","by","apoptosis","."),4088561). assertion_content_comment('tOboGo_NurseCellNucleusAnchoring',s("Attachment","of","the","nurse","cell","nucleus","to","the","plasma","membrane","."),4018849). assertion_content_comment('tOboGo_NutrientExport',s("OBSOLETE",".","The","directed","movement","of","nutrients","out","of","a","cell","or","organelle","."),4331433). assertion_content_comment('tOboGo_NutrientImport',s("OBSOLETE",".","The","directed","movement","of","nutrients","into","a","cell","or","organelle","."),4261798). assertion_content_comment('tOboGo_NutrientReservoirActivity',s("Functions","in","the","storage","of","nutritious","substrates","."),4216970). assertion_content_comment('tOboGo_NylonCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nylon",",","a","polymer","where","the","main","polymer","chain","comprises","recurring","amide","groups",";","these","compounds","are","generally","formed","from","combinations","of","diamines",",","diacids","and","amino","acids","."),4234163). assertion_content_comment('tOboGo_NylonMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nylon",",","a","polymer","where","the","main","polymer","chain","comprises","recurring","amide","groups",";","these","compounds","are","generally","formed","from","combinations","of","diamines",",","diacids","and","amino","acids","."),4234160). assertion_content_comment('tOboGo_OAntigenBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","O","side","chain","of","a","lipopolysaccharide",",","which","determines","the","antigenic","specificity","of","the","organism",".","It","is","made","up","of","about","50","repeating","units","of","a","branched","tetrasaccharide","."),4023954). assertion_content_comment('tOboGo_OAntigenLigaseActivity',s("Catalysis","of","the","reaction",":","Lipid","A-core","+","colanic","acid","=","MLPS","."),4251563). assertion_content_comment('tOboGo_OAntigenMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","O","side","chain","of","a","lipopolysaccharide",",","which","determines","the","antigenic","specificity","of","the","organism",".","It","is","made","up","of","about","50","repeating","units","of","a","branched","tetrasaccharide","."),4023950). assertion_content_comment('tOboGo_OAntigenPolymeraseActivity',s("Catalysis","of","the","polymerization","of","o-antigen","chains",".","O-antigens","are","tetra-","and","pentasaccharide","repeat","units","of","the","cell","walls","of","Gram-negative","bacteria","and","are","a","component","of","lipopolysaccharide","."),4251476). assertion_content_comment('tOboGo_ObsoleteBiologicalProcess',s("OBSOLETE",".","These","are","terms","that","have","been","removed","from","the","active","process","ontology","."),4255047). assertion_content_comment('tOboGo_ObsoleteCellularComponent',s("OBSOLETE",".","These","are","terms","that","have","been","removed","from","the","active","component","ontology","."),4255057). assertion_content_comment('tOboGo_ObsoleteMolecularFunction',s("OBSOLETE",".","These","are","terms","that","have","been","removed","from","the","active","function","ontology","."),4255024). assertion_content_comment('tOboGo_OccludingJunction',s("A","cell-cell","junction","that","seals","cells","together","in","an","epithelium","in","a","way","that","prevents","even","small","molecules","from","leaking","from","one","side","of","the","sheet","to","the","other","."),4008160). assertion_content_comment('tOboGo_OcclusionByHostOfSymbiontVascularSystem',s("The","process","in","which","an","organism","reduces","the","flow","of","fluid","within","its","symbiont","'","s","vascular","system",",","the","vessels","and","tissue","that","carry","or","circulate","fluids",",","such","as","blood",",","lymph","or","sap",",","through","the","body","of","an","animal","or","plant",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4187485). assertion_content_comment('tOboGo_OcclusionByHostOfSymbiontXylem',s("The","process","in","which","an","organism","reduces","the","flow","of","fluid","within","the","symbiont","xylem",",","the","tissue","in","plants","that","carries","water","and","nutrients","up","from","the","roots","to","the","shoot","and","leaves",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4187537). assertion_content_comment('tOboGo_OcclusionByOrganismOfVascularSystemInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","reduces","the","flow","of","fluid","within","its","second","organism","'","s","vascular","system",",","the","vessels","and","tissue","that","carry","or","circulate","fluids",",","such","as","blood",",","lymph","or","sap",",","through","the","body","of","an","animal","or","plant",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4187482). assertion_content_comment('tOboGo_OcclusionByOrganismOfXylemInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","reduces","the","flow","of","fluid","within","the","xylem",",","the","tissue","in","plants","that","carries","water","and","nutrients","up","from","the","roots","to","the","shoot","and","leaves",",","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4187508). assertion_content_comment('tOboGo_OcclusionBySymbiontOfHostVascularSystem',s("The","process","in","which","an","organism","reduces","the","flow","of","fluid","within","its","host","'","s","vascular","system",",","the","vessels","and","tissue","that","carry","or","circulate","fluids",",","such","as","blood",",","lymph","or","sap",",","through","the","body","of","an","animal","or","plant",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4196259). assertion_content_comment('tOboGo_OcclusionBySymbiontOfHostXylem',s("The","process","in","which","an","organism","reduces","the","flow","of","fluid","within","the","host","xylem",",","the","tissue","in","plants","that","carries","water","and","nutrients","up","from","the","roots","to","the","shoot","and","leaves",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4196262). assertion_content_comment('tOboGo_OcellusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","ocellus","over","time",",","from","its","formation","to","the","mature","structure",".","The","ocellus","is","a","simple","visual","organ","of","insects","."),4014859). assertion_content_comment('tOboGo_OcellusMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","ocellus","are","generated","and","organized",".","The","ocellus","is","a","simple","visual","organ","of","insects","."),4105156). assertion_content_comment('tOboGo_OcellusPhotoreceptorCellDevelopment',s("Development","of","photoreceptors",",","sensory","cells","that","react","to","the","presence","of","light",",","found","in","the","ocellus","."),4078705). assertion_content_comment('tOboGo_OcellusPhotoreceptorCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","photoreceptor","cell","found","in","the","ocellus","."),4078209). assertion_content_comment('tOboGo_OcellusPhotoreceptorCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","photoreceptor","cell","in","the","ocellus",".","A","photoreceptor","cell","is","a","cell","that","responds","to","incident","electromagnetic","radiation",".","Different","classes","of","photoreceptor","have","different","spectral","sensitivities","and","express","different","photosensitive","pigments","."),4078219). assertion_content_comment('tOboGo_OcellusPigmentation',s("The","deposition","or","aggregation","of","coloring","matter","in","an","ocellus",",","a","minute","simple","eye","found","in","many","invertebrates","."),4091855). assertion_content_comment('tOboGo_OcellusPigmentBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ocellus","pigments",",","any","general","or","particular","coloring","matter","in","living","organisms",",","found","or","utilized","in","the","ocellus",",","a","minute","simple","eye","found","in","many","invertebrates","."),4229409). assertion_content_comment('tOboGo_OcellusPigmentCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ocellus","pigments",",","any","general","or","particular","coloring","matter","in","living","organisms",",","found","or","utilized","in","the","ocellus",",","a","minute","simple","eye","found","in","many","invertebrates","."),4352002). assertion_content_comment('tOboGo_OcellusPigmentGranuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","intracellular","pigment","storage","granules","in","the","ocellus","."),4246781). assertion_content_comment('tOboGo_OcellusPigmentMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ocellus","pigments",",","any","general","or","particular","coloring","matter","in","living","organisms",",","found","or","utilized","in","the","ocellus",",","a","minute","simple","eye","found","in","many","invertebrates","."),4091866). assertion_content_comment('tOboGo_OctadecanalDecarbonylaseActivity',s("Catalysis","of","the","reaction",":","octadecanal","=","heptadecane","+","CO","."),4261850). assertion_content_comment('tOboGo_OctamethylcyclotetrasiloxaneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","octamethylcyclotetrasiloxane",",","a","cyclic","silicone-oxygen","ring","compound","with","two","methyl","groups","attached","to","each","silicone","atom","."),4314386). assertion_content_comment('tOboGo_OctamethylcyclotetrasiloxaneCatabolicProcessToDimethylsilanediol',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","octamethylcyclotetrasiloxane","into","dimethylsilanediol",".","The","former","is","a","tetramer","of","the","latter","."),4314391). assertion_content_comment('tOboGo_OctamethylcyclotetrasiloxaneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","octamethylcyclotetrasiloxane",",","a","cyclic","silicone-oxygen","ring","compound","with","two","methyl","groups","attached","to","each","silicone","atom","."),4314383). assertion_content_comment('tOboGo_OctanolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","octanol",",","the","8-carbon","alcohol","with","the","formula","C8H17OH","."),4351599). assertion_content_comment('tOboGo_OctanolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","octanol",",","the","8-carbon","alcohol","with","the","formula","C8H17OH","."),4351585). assertion_content_comment('tOboGo_OctanolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","1-octanol","+","NAD","(","+",")","=","1-octanal","+","H","(","+",")","+","NADH","."),4204741). assertion_content_comment('tOboGo_OctanolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","octanol",",","the","8-carbon","alcohol","with","the","formula","C8H17OH","."),4225081). assertion_content_comment('tOboGo_OctanoyltransferaseActivity',s("Catalysis","of","the","transfer","of","an","octanoyl","(","CH3-","[","CH2","]","6-CO-",")","group","to","an","acceptor","molecule","."),4254017). assertion_content_comment('tOboGo_OctopamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","octopamine",",","1-","(","p-hydroxyphenyl",")","-2-aminoethanol",".","The","D","enantiomer","is","about","one-tenth","as","active","as","norepinephrine","and","is","found","in","the","salivary","glands","of","Octopus","and","Eledone","species","."),4231930). assertion_content_comment('tOboGo_OctopamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","octopamine",",","1-","(","p-hydroxyphenyl",")","-2-aminoethanol",".","The","D","enantiomer","is","about","one-tenth","as","active","as","norepinephrine","and","is","found","in","the","salivary","glands","of","Octopus","and","Eledone","species","."),4350020). assertion_content_comment('tOboGo_OctopamineDehydrataseActivity',s("Catalysis","of","the","reaction",":","1-","(","4-hydroxyphenyl",")","-2-aminoethanol","=","(","4-hydroxyphenyl",")","acetaldehyde","+","NH","(","4",")","(","+",")"),4264416). assertion_content_comment('tOboGo_OctopamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","octopamine",",","1-","(","p-hydroxyphenyl",")","-2-aminoethanol",".","The","D","enantiomer","is","about","one-tenth","as","active","as","norepinephrine","and","is","found","in","the","salivary","glands","of","Octopus","and","Eledone","species","."),4231927). assertion_content_comment('tOboGo_OctopamineOrTyramineSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","octopamine","or","tyramine","binding","to","a","cell","surface","receptor",".","Octopamine","and","tyramine","are","decarboxylation","products","of","tyrosine",",","and","are","the","invertebrate","counterparts","of","the","vertebrate","adrenergic","transmitters","."),4125837). assertion_content_comment('tOboGo_OctopamineReceptorActivity',s("Combining","with","the","biogenic","amine","octopamine","to","initiate","a","change","in","cell","activity",".","Octopamine","is","found","in","both","vertebrates","and","invertebrates","and","can","have","properties","both","of","a","hormone","and","a","neurotransmitter","and","acts","as","an","adrenergic","agonist","."),4198922). assertion_content_comment('tOboGo_OctopamineSignalingPathwayInvolvedInResponseToFood',s("The","series","of","molecular","signals","initiated","by","binding","of","octopamine","to","a","receptor","on","the","surface","of","the","target","cell","that","contributes","to","a","response","to","a","food","stimulus","."),4125845). assertion_content_comment('tOboGo_OctopamineSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","octopamine","binding","to","a","cell","surface","receptor","."),4125841). assertion_content_comment('tOboGo_OctopineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","octopine","(","N-","(","1-carboxy-4-guanidinobutyl",")","-L-alanine",")",",","an","amino","acid","derived","opine","."),4241548). assertion_content_comment('tOboGo_OctopineCatabolicProcessToProline',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","octopine","into","other","compounds",",","including","proline","."),4313344). assertion_content_comment('tOboGo_OctopineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","octopine",",","(","N-","(","1-carboxy-4-guanidinobutyl",")","-L-alanine",")",",","an","amino","acid","derived","opine","."),4241545). assertion_content_comment('tOboGo_OculomotorNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","oculomotor","nerve","over","time",",","from","its","formation","to","the","mature","structure",".","This","motor","nerve","innervates","all","extraocular","muscles","except","the","superior","oblique","and","the","lateral","rectus","muscles",".","The","superior","division","supplies","the","levator","palpebrae","superioris","and","superior","rectus","muscles",".","The","inferior","division","supplies","the","medial","rectus",",","inferior","rectus","and","inferior","oblique","muscles",".","This","nerve","also","innervates","the","striated","muscles","of","the","eyelid",".","Pupillary","constriction","and","lens","movement","are","mediated","by","this","nerve","for","near","vision",".","In","the","orbit","the","inferior","division","sends","branches","that","enter","the","ciliary","ganglion","where","they","form","functional","contacts","(","synapses",")","with","the","ganglion","cells",".","The","ganglion","cells","send","nerve","fibers","into","the","back","of","the","eye","where","they","travel","to","ultimately","innervate","the","ciliary","muscle","and","the","constrictor","pupillae","muscle","."),4044347). assertion_content_comment('tOboGo_OculomotorNerveFormation',s("The","process","that","gives","rise","to","the","oculomotor","nerve",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","This","motor","nerve","innervates","all","extraocular","muscles","except","the","superior","oblique","and","the","lateral","rectus","muscles",".","The","superior","division","supplies","the","levator","palpebrae","superioris","and","superior","rectus","muscles",".","The","inferior","division","supplies","the","medial","rectus",",","inferior","rectus","and","inferior","oblique","muscles",".","This","nerve","also","innervates","the","striated","muscles","of","the","eyelid",".","Pupillary","constriction","and","lens","movement","are","mediated","by","this","nerve","for","near","vision",".","In","the","orbit","the","inferior","division","sends","branches","that","enter","the","ciliary","ganglion","where","they","form","functional","contacts","(","synapses",")","with","the","ganglion","cells",".","The","ganglion","cells","send","nerve","fibers","into","the","back","of","the","eye","where","they","travel","to","ultimately","innervate","the","ciliary","muscle","and","the","constrictor","pupillae","muscle","."),4044364). assertion_content_comment('tOboGo_OculomotorNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","oculomotor","nerve","to","attain","its","fully","functional","state",".","This","motor","nerve","innervates","all","extraocular","muscles","except","the","superior","oblique","and","the","lateral","rectus","muscles",".","The","superior","division","supplies","the","levator","palpebrae","superioris","and","superior","rectus","muscles",".","The","inferior","division","supplies","the","medial","rectus",",","inferior","rectus","and","inferior","oblique","muscles",".","This","nerve","also","innervates","the","striated","muscles","of","the","eyelid",".","Pupillary","constriction","and","lens","movement","are","mediated","by","this","nerve","for","near","vision",".","In","the","orbit","the","inferior","division","sends","branches","that","enter","the","ciliary","ganglion","where","they","form","functional","contacts","(","synapses",")","with","the","ganglion","cells",".","The","ganglion","cells","send","nerve","fibers","into","the","back","of","the","eye","where","they","travel","to","ultimately","innervate","the","ciliary","muscle","and","the","constrictor","pupillae","muscle","."),4044426). assertion_content_comment('tOboGo_OculomotorNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","oculomotor","nerve","is","generated","and","organized",".","This","motor","nerve","innervates","all","extraocular","muscles","except","the","superior","oblique","and","the","lateral","rectus","muscles",".","The","superior","division","supplies","the","levator","palpebrae","superioris","and","superior","rectus","muscles",".","The","inferior","division","supplies","the","medial","rectus",",","inferior","rectus","and","inferior","oblique","muscles",".","This","nerve","also","innervates","the","striated","muscles","of","the","eyelid",".","Pupillary","constriction","and","lens","movement","are","mediated","by","this","nerve","for","near","vision",".","In","the","orbit","the","inferior","division","sends","branches","that","enter","the","ciliary","ganglion","where","they","form","functional","contacts","(","synapses",")","with","the","ganglion","cells",".","The","ganglion","cells","send","nerve","fibers","into","the","back","of","the","eye","where","they","travel","to","ultimately","innervate","the","ciliary","muscle","and","the","constrictor","pupillae","muscle","."),4044352). assertion_content_comment('tOboGo_OculomotorNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","oculomotor","nerve",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","This","motor","nerve","innervates","all","extraocular","muscles","except","the","superior","oblique","and","the","lateral","rectus","muscles",".","The","superior","division","supplies","the","levator","palpebrae","superioris","and","superior","rectus","muscles",".","The","inferior","division","supplies","the","medial","rectus",",","inferior","rectus","and","inferior","oblique","muscles",".","This","nerve","also","innervates","the","striated","muscles","of","the","eyelid",".","Pupillary","constriction","and","lens","movement","are","mediated","by","this","nerve","for","near","vision",".","In","the","orbit","the","inferior","division","sends","branches","that","enter","the","ciliary","ganglion","where","they","form","functional","contacts","(","synapses",")","with","the","ganglion","cells",".","The","ganglion","cells","send","nerve","fibers","into","the","back","of","the","eye","where","they","travel","to","ultimately","innervate","the","ciliary","muscle","and","the","constrictor","pupillae","muscle","."),4044377). assertion_content_comment('tOboGo_OdontoblastDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","of","neural","crest","origin","acquires","the","specialized","features","of","an","odontoblast",",","a","cell","on","the","outer","surface","of","the","dental","pulp","whose","biological","function","is","the","creation","of","dentine","."),4170679). assertion_content_comment('tOboGo_Odontogenesis',s("The","process","whose","specific","outcome","is","the","progression","of","a","tooth","or","teeth","over","time",",","from","formation","to","the","mature","structure","(","s",")","A","tooth","is","any","hard","bony",",","calcareous",",","or","chitinous","organ","found","in","the","mouth","or","pharynx","of","an","animal","and","used","in","procuring","or","masticating","food","."),4073573). assertion_content_comment('tOboGo_OdorantBinding',s("Interacting","selectively","and","non-covalently","with","an","odorant",",","any","substance","capable","of","stimulating","the","sense","of","smell","."),4218232). assertion_content_comment('tOboGo_OdorantTransporterActivity',s("Enables","the","directed","movement","of","odorants",",","any","substance","capable","of","stimulating","the","sense","of","smell",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4325406). assertion_content_comment('tOboGo_OenocyteDelamination',s("The","negative","regulation","of","cell","adhesion","process","in","which","an","oenocyte","splits","off","of","an","existing","epithelial","sheet","."),4160075). assertion_content_comment('tOboGo_OenocyteDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","oenocyte","over","time",",","from","its","formation","to","the","mature","structure",".","The","oenocytes","are","large","secretory","cells","found","in","clusters","underlying","the","epidermis","of","larval","abdominal","segments","."),4017502). assertion_content_comment('tOboGo_OenocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","oenocyte",".","Oenocytes","are","large","secretory","cells","found","in","clusters","underlying","the","epidermis","of","larval","abdominal","segments","."),4017491). assertion_content_comment('tOboGo_OidiumFormation',s("The","process","in","which","oidia",",","a","type","of","asexual","spore","found","in","fungi",",","are","formed",".","Oidia","are","borne","a","few","at","a","time","on","very","simple","hyphae","that","protrude","a","short","distance","into","the","substrate",",","and","are","usually","presumed","not","to","constitute","the","main","reproductive","strategy","of","the","fungus","."),4360111). assertion_content_comment('tOboGo_OleateHydrataseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-10-hydroxystearate","=","H","(","2",")","O","+","oleate","."),4271385). assertion_content_comment('tOboGo_OleicAcidBinding',s("Interacting","selectively","and","non-covalently","with","oleic","acid",",","the","18-carbon","monounsaturated","fatty","acid","(","9Z",")","-octadec-9-enoic","acid","."),4174499). assertion_content_comment('tOboGo_OlfactoryBehavior',s("The","actions","or","reactions","of","an","organism","in","response","to","an","odor","."),4150515). assertion_content_comment('tOboGo_OlfactoryBulbAxonGuidance',s("The","process","in","which","the","migration","of","an","axon","growth","cone","of","a","neuron","in","the","olfactory","bulb","is","directed","to","its","target","in","the","brain","in","response","to","a","combination","of","attractive","and","repulsive","cues","."),4172413). assertion_content_comment('tOboGo_OlfactoryBulbDevelopment',s("The","progression","of","the","olfactory","bulb","over","time","from","its","initial","formation","until","its","mature","state",".","The","olfactory","bulb","coordinates","neuronal","signaling","involved","in","the","perception","of","smell",".","It","receives","input","from","the","sensory","neurons","and","outputs","to","the","olfactory","cortex","."),4047631). assertion_content_comment('tOboGo_OlfactoryBulbInterneuronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","interneuron","residing","in","the","olfactory","bulb",",","from","its","initial","commitment",",","to","the","fully","functional","differentiated","cell","."),4047665). assertion_content_comment('tOboGo_OlfactoryBulbInterneuronDifferentiation',s("The","process","in","which","a","neuroblast","acquires","specialized","features","of","an","interneuron","residing","in","the","olfactory","bulb","."),4047633). assertion_content_comment('tOboGo_OlfactoryBulbInterneuronFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","neuroblast","becomes","restricted","such","that","it","will","develop","into","an","interneuron","residing","in","the","olfactory","bulb","."),4047676). assertion_content_comment('tOboGo_OlfactoryBulbMitralCellLayerDevelopment',s("The","progression","of","the","olfactory","bulb","mitral","cell","layer","over","time","from","its","initial","formation","until","its","mature","state",".","The","mitral","cell","layer","is","composed","of","pyramidal","neurons","whose","cell","bodies","are","located","between","the","granule","cell","layer","and","the","plexiform","layer","."),4113311). assertion_content_comment('tOboGo_OlfactoryCortexDevelopment',s("The","progression","of","the","olfactory","cortex","over","time","from","its","initial","formation","until","its","mature","state",".","The","olfactory","cortex","is","involved","in","the","perception","of","smell",".","It","receives","input","from","the","olfactory","bulb","and","is","responsible","for","the","identification","of","odors","."),4046374). assertion_content_comment('tOboGo_OlfactoryLearning',s("Any","process","in","an","organism","in","which","a","relatively","long-lasting","adaptive","behavioral","change","occurs","in","response","to","(","repeated",")","exposure","to","an","olfactory","cue","."),4150523). assertion_content_comment('tOboGo_OlfactoryLobeDevelopment',s("The","progression","of","the","olfactory","lobe","over","time","from","its","initial","formation","until","its","mature","state",".","The","olfactory","lobe","is","the","area","of","the","brain","that","process","the","neural","inputs","for","the","sense","of","smell","."),4046372). assertion_content_comment('tOboGo_OlfactoryNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","olfactory","nerve","over","time",",","from","its","formation","to","the","mature","structure",".","The","olfactory","nerve","is","a","collection","of","sensory","nerve","rootlets","that","extend","down","from","the","olfactory","bulb","to","the","olfactory","mucosa","of","the","upper","parts","of","the","nasal","cavity",".","This","nerve","conducts","odor","information","to","the","brainstem","."),4044400). assertion_content_comment('tOboGo_OlfactoryNerveFormation',s("The","process","that","gives","rise","to","the","olfactory","nerve",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","olfactory","nerve","is","a","collection","of","sensory","nerve","rootlets","that","extend","down","from","the","olfactory","bulb","to","the","olfactory","mucosa","of","the","upper","parts","of","the","nasal","cavity",".","This","nerve","conducts","odor","information","to","the","brainstem","."),4044462). assertion_content_comment('tOboGo_OlfactoryNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","olfactory","nerve","to","attain","its","fully","functional","state",".","The","olfactory","nerve","is","a","collection","of","sensory","nerve","rootlets","that","extend","down","from","the","olfactory","bulb","to","the","olfactory","mucosa","of","the","upper","parts","of","the","nasal","cavity",".","This","nerve","conducts","odor","information","to","the","brainstem","."),4044438). assertion_content_comment('tOboGo_OlfactoryNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","olfactory","nerve","is","generated","and","organized",".","The","olfactory","nerve","is","a","collection","of","sensory","nerve","rootlets","that","extend","down","from","the","olfactory","bulb","to","the","olfactory","mucosa","of","the","upper","parts","of","the","nasal","cavity",".","This","nerve","conducts","odor","information","to","the","brainstem","."),4044414). assertion_content_comment('tOboGo_OlfactoryNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","oculomotor","nerve",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","olfactory","nerve","is","a","collection","of","sensory","nerve","rootlets","that","extend","down","from","the","olfactory","bulb","to","the","olfactory","mucosa","of","the","upper","parts","of","the","nasal","cavity",".","This","nerve","conducts","odor","information","to","the","brainstem","."),4044450). assertion_content_comment('tOboGo_OlfactoryPitDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","the","olfactory","pit","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","olfactory","pit",",","which","is","an","indentation","of","the","olfactory","placode",",","and","ends","when","the","pits","hollows","out","to","form","the","nasopharynx","."),4108399). assertion_content_comment('tOboGo_OlfactoryPlacodeDevelopment',s("The","progression","of","the","olfactory","placode","over","time","from","its","initial","formation","until","its","mature","state",".","The","olfactory","placode","is","a","thickening","of","the","neural","ectoderm","in","the","head","region","of","the","vertebrate","embryo","which","develops","into","the","olfactory","region","of","the","nasal","cavity","."),4061396). assertion_content_comment('tOboGo_OlfactoryPlacodeFormation',s("The","formation","of","a","thickening","of","the","neural","ectoderm","in","the","head","region","of","the","vertebrate","embryo","which","develops","into","the","olfactory","region","of","the","nasal","cavity","."),4061420). assertion_content_comment('tOboGo_OlfactoryPlacodeMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","olfactory","placode","to","attain","its","fully","functional","state",".","The","olfactory","placode","is","a","thickening","of","the","neural","ectoderm","in","the","head","region","of","the","vertebrate","embryo","which","develops","into","the","olfactory","region","of","the","nasal","cavity","."),4129017). assertion_content_comment('tOboGo_OlfactoryPlacodeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","olfactory","placode","are","generated","and","organized",".","The","olfactory","placode","is","a","thickening","of","the","neural","ectoderm","in","the","head","region","of","the","vertebrate","embryo","which","develops","into","the","olfactory","region","of","the","nasal","cavity","."),4061398). assertion_content_comment('tOboGo_OlfactoryReceptorActivity',s("Combining","with","airborne","compounds","to","initiate","a","change","in","cell","activity",".","These","receptors","are","used","for","the","sense","of","smell","."),4198876). assertion_content_comment('tOboGo_OlfactoryReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","olfactory","receptor","."),4324073). assertion_content_comment('tOboGo_OligodendrocyteCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","an","oligodendrocyte","."),4041238). assertion_content_comment('tOboGo_OligodendrocyteCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","oligodendrocyte","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",".","Upon","specification",",","the","cell","fate","can","be","reversed","."),4041240). assertion_content_comment('tOboGo_OligodendrocyteCellMigrationFromTheSubpalliumToTheCortex',s("The","directed","movement","of","oligodendrocytes","from","the","subpallium","to","the","cerebral","cortex","during","forebrain","development","."),4051302). assertion_content_comment('tOboGo_OligodendrocyteDevelopment',s("The","process","aimed","at","the","progression","of","an","oligodendrocyte","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell",".","An","oligodendrocyte","is","a","type","of","glial","cell","involved","in","myelinating","the","axons","in","the","central","nervous","system","."),4036384). assertion_content_comment('tOboGo_OligodendrocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","oligodendrocyte",".","An","oligodendrocyte","is","a","type","of","glial","cell","involved","in","myelinating","the","axons","of","neurons","in","the","central","nervous","system","."),4036374). assertion_content_comment('tOboGo_OligodendrocyteProgenitorProliferation',s("The","multiplication","or","reproduction","of","oligodendrocyte","progenitor","cells","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","Oligodendrocyte","progenitors","give","rise","to","oligodendrocytes",",","which","form","the","insulating","myelin","sheath","of","axons","in","the","central","nervous","system","."),4136305). assertion_content_comment('tOboGo_OligodeoxyribonucleotidaseActivity',s("Catalysis","of","the","exonucleolytic","cleavage","of","oligodeoxyribonucleotides","to","yield","deoxyribonucleoside","5","'","-phosphates","."),4353907). assertion_content_comment('tOboGo_OligogalacturonideLyaseActivity',s("Catalysis","of","the","reaction",":","4-","(","4-deoxy-beta-D-gluc-4-enuronosyl",")","-D-galacturonate","=","25-dehydro-4-deoxy-D-glucuronate","."),4369727). assertion_content_comment('tOboGo_OligogalacturonideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","oligogalacturonide","from","one","side","of","the","membrane","to","the","other","."),4347842). assertion_content_comment('tOboGo_OligogalacturonideTransportingATPaseActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","oligogalacturonide","(","out",")","=","ADP","+","phosphate","+","oligogalacturonide","(","in",")"),4347879). assertion_content_comment('tOboGo_OligogalacturonideTransport',s("The","directed","movement","of","oligogalacturonides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4347851). assertion_content_comment('tOboGo_OligonucleotidaseActivity',s("Catalysis","of","the","exonucleolytic","cleavage","of","oligonucleotides","to","yield","nucleoside","5","'","-phosphates","."),4247547). assertion_content_comment('tOboGo_OligopeptidaseAActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","oligopeptides",",","with","broad","specificity",".","Gly","or","Ala","commonly","occur","as","P1","or","P1","'","residues",",","but","more","distant","residues","are","also","important",",","as","is","shown","by","the","fact","that","Z-Gly-Pro-Gly-Gly-Pro-Ala","is","cleaved","at","the","Gly-Gly","bond",",","but","not","Z-","(","Gly",")","5","."),4247573). assertion_content_comment('tOboGo_OligopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","a","peptide","bond","in","an","oligopeptide",",","i.e",".","a","molecule","containing","a","small","number","(","2","to","20",")","of","amino","acid","residues","connected","by","peptide","bonds","."),4180357). assertion_content_comment('tOboGo_OligopeptidaseBActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","Arg-Xaa","and","Lys-Xaa","bonds","in","oligopeptides",",","even","when","P1","'","residue","is","proline","."),4247559). assertion_content_comment('tOboGo_OligopeptideExportFromMitochondrion',s("The","directed","movement","of","oligopeptides","out","of","mitochondria","into","the","cytosol","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Oligopeptides","are","molecules","that","contain","a","small","number","(","2","to","20",")","of","amino-acid","residues","connected","by","peptide","linkages","."),4155235). assertion_content_comment('tOboGo_OligopeptideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","oligopeptides","from","one","side","of","the","membrane","to","the","other","."),4168312). assertion_content_comment('tOboGo_OligopeptideTransmembraneTransport',s("The","directed","movement","of","an","oligopeptide","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Oligopeptides","are","molecules","that","contain","a","small","number","(","2","to","20",")","of","amino-acid","residues","connected","by","peptide","linkages","."),4155233). assertion_content_comment('tOboGo_OligopeptideTransporterActivity',s("Enables","the","directed","movement","of","oligopeptides","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Oligopeptides","are","molecules","that","contain","a","small","number","(","2","to","20",")","of","amino-acid","residues","connected","by","peptide","linkages","."),4168309). assertion_content_comment('tOboGo_OligopeptideTransport',s("The","directed","movement","of","oligopeptides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Oligopeptides","are","molecules","that","contain","a","small","number","(","2","to","20",")","of","amino-acid","residues","connected","by","peptide","linkages","."),4150244). assertion_content_comment('tOboGo_OligoribonucleotidaseActivity',s("Catalysis","of","the","exonucleolytic","cleavage","of","oligoribonucleotides","to","yield","ribonucleoside","5","'","-phosphates","."),4353918). assertion_content_comment('tOboGo_OligosaccharideBinding',s("Interacting","selectively","and","non-covalently","with","any","oligosaccharide",",","a","molecule","with","between","two","and","(","about",")","20","monosaccharide","residues","connected","by","glycosidic","linkages","."),4175766). assertion_content_comment('tOboGo_OligosaccharideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","oligosaccharides",",","molecules","with","between","two","and","(","about",")","20","monosaccharide","residues","connected","by","glycosidic","linkages","."),4009827). assertion_content_comment('tOboGo_OligosaccharideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","oligosaccharides",",","molecules","with","between","two","and","(","about",")","20","monosaccharide","residues","connected","by","glycosidic","linkages","."),4220826). assertion_content_comment('tOboGo_OligosaccharideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","oligosaccharides",",","molecules","with","between","two","and","(","about",")","20","monosaccharide","residues","connected","by","glycosidic","linkages","."),4009823). assertion_content_comment('tOboGo_OligosaccharideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","oligosaccharide","from","one","side","of","the","membrane","to","the","other","."),4289513). assertion_content_comment('tOboGo_OligosaccharideTransportingPorinActivity',s("Catalysis","of","the","transfer","of","oligosaccharide",",","sized","less","than","1000","Da",",","from","one","side","of","the","membrane","to","the","other",".","The","transmembrane","portions","of","porins","consist","exclusively","of","beta-strands","which","form","a","beta-barrel",".","They","are","found","in","the","outer","membranes","of","Gram-negative","bacteria",",","mitochondria",",","plastids","and","possibly","acid-fast","Gram-positive","bacteria","."),4292349). assertion_content_comment('tOboGo_OligosaccharideTransport',s("The","directed","movement","of","oligosaccharides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Oligosaccharides","are","molecules","with","between","two","and","(","about",")","20","monosaccharide","residues","connected","by","glycosidic","linkages","."),4157438). assertion_content_comment('tOboGo_OligosaccharylTransferaseActivity',s("Catalysis","of","the","transfer","of","a","oligosaccharyl","group","to","an","acceptor","molecule",",","typically","another","carbohydrate","or","a","lipid","."),4204284). assertion_content_comment('tOboGo_OligosaccharyltransferaseComplex',s("A","protein","complex","that","is","found","in","the","endoplasmic","reticulum","membrane","of","eukaryotes","and","transfers","lipid-linked","oligosaccharide","precursor","to","asparagine","residues","on","nascent","proteins",".","In","yeast",",","the","complex","includes","at","least","nine","different","subunits",",","whereas","in","mammalian","cells","at","least","three","different","forms","of","the","complex","have","been","detected","."),4016062). assertion_content_comment('tOboGo_OligosaccharyltransferaseIComplex',s("An","oligosaccharyltransferase","(","OST",")","complex","that","contains","at","least","seven","polypeptides","and","is","the","major","OST","complex","in","mammalian","cells",".","Of","the","three","forms","of","mammalian","OST","complex","identified",",","the","OSTI","complex","has","the","weakest","affinity","for","ribosomes","."),4348435). assertion_content_comment('tOboGo_OligosaccharyltransferaseIIComplex',s("An","oligosaccharyltransferase","(","OST",")","complex","that","contains","the","seven","polypeptides","found","in","OST","complex","I",",","plus","heterotrimeric","Sec61alpha-beta-gamma",".","Of","the","three","forms","of","mammalian","OST","complexes","identified",",","the","OSTII","complex","has","intermediate","affinity","for","ribosomes","."),4348445). assertion_content_comment('tOboGo_OligosaccharyltransferaseIIIComplex',s("An","oligosaccharyltransferase","(","OST",")","complex","that","contains","the","seven","polypeptides","found","in","OST","complex","I",",","plus","heterotrimeric","Sec61alpha-beta-gamma","and","the","tetrameric","TRAP","complex",".","Of","the","three","forms","of","mammalian","OST","complexes","identified",",","the","OSTIII","complex","has","the","strongest","affinity","for","ribosomes","."),4381868). assertion_content_comment('tOboGo_OmegaPeptidaseActivity',s("Catalysis","of","the","removal","of","terminal","peptide","residues","that","are","substituted",",","cyclized","or","linked","by","isopeptide","bonds","(","peptide","linkages","other","than","those","of","alpha-carboxyl","to","alpha-amino","groups",")"),4209207). assertion_content_comment('tOboGo_OmegaSpeckle',s("A","nucleoplasmic","speckle","distributed","in","the","interchromatin","space","of","cells","in","close","proximity","to","chromatin",".","Omega","speckles","are","distinct","from","interchromatin","granules","and","contain","heterogeneous","nuclear","RNA-binding","proteins","(","hnRNPs",")"),4381819). assertion_content_comment('tOboGo_OmmatidialRotation',s("The","process","in","which","photoreceptors","are","arranged","in","ommatidia","in","the","dorsal","and","ventral","fields","to","be","mirror","images",".","The","polarity","is","established","in","the","imaginal","discs","concurrently","with","cell","fate","specification","."),4034601). assertion_content_comment('tOboGo_OmmochromeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ommochromes",",","any","of","a","large","group","of","natural","polycyclic","pigments","commonly","found","in","the","Arthropoda",",","particularly","in","the","ommatidia","of","the","compound","eye","."),4229430). assertion_content_comment('tOboGo_OmmochromeCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ommochromes",",","any","of","a","large","group","of","natural","polycyclic","pigments","commonly","found","in","the","Arthropoda",",","particularly","in","the","ommatidia","of","the","compound","eye","."),4352008). assertion_content_comment('tOboGo_OmmochromeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ommochromes",",","any","of","a","large","group","of","natural","polycyclic","pigments","commonly","found","in","the","Arthropoda",",","particularly","in","the","ommatidia","of","the","compound","eye","."),4229427). assertion_content_comment('tOboGo_OmptinActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","of","Xaa-Yaa","in","which","both","Xaa","and","Yaa","are","Arg","or","Lys","."),4247536). assertion_content_comment('tOboGo_Oncogenesis',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235337). assertion_content_comment('tOboGo_Oncosis',s("A","cellular","process","that","results","in","swelling","of","the","cell","body",",","and","that","is","morphologically","characteristic","of","necrotic","cell","death","."),4136952). assertion_content_comment('tOboGo_OocyteAnimalVegetalAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","animal/vegetal","axis","in","the","oocyte",".","The","animal/vegetal","axis","of","an","oocyte","is","defined","by","the","placement","of","the","nucleus","in","the","oocyte","and","can","sometimes","be","identified","by","the","asymmetric","placement","of","other","substances","such","as","yolk","in","the","oocyte",".","The","pole","of","the","egg","that","is","closest","to","the","nucleus","defines","the","animal","end",",","with","the","axis","passing","through","the","nucleus","."),4113722). assertion_content_comment('tOboGo_OocyteAnteriorPosteriorAxisSpecification',s("Polarization","of","the","oocyte","along","its","anterior-posterior","axis",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4018954). assertion_content_comment('tOboGo_OocyteAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","an","axis","in","the","oocyte",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4015122). assertion_content_comment('tOboGo_OocyteConstruction',s("The","synthesis",",","deposition",",","and","organization","of","the","materials","in","a","cell","of","an","ovary",";","where","the","cell","can","then","undergo","meiosis","and","form","an","ovum",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4015096). assertion_content_comment('tOboGo_OocyteDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","oocyte","over","time",",","from","initial","commitment","of","the","cell","to","its","specific","fate",",","to","the","fully","functional","differentiated","cell","."),3980993). assertion_content_comment('tOboGo_OocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","immature","germ","cell","acquires","the","specialized","features","of","a","mature","female","gamete","."),3980990). assertion_content_comment('tOboGo_OocyteDorsalVentralAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","dorsal/ventral","axis","of","the","oocyte",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4052030). assertion_content_comment('tOboGo_OocyteFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","an","oocyte","."),4106435). assertion_content_comment('tOboGo_OocyteFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","oocyte","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4016901). assertion_content_comment('tOboGo_OocyteGrowth',s("The","developmental","growth","process","in","which","an","oocyte","irreversibly","increases","in","size","over","time","by","accretion","and","biosynthetic","production","of","matter","similar","to","that","already","present","."),3981181). assertion_content_comment('tOboGo_OocyteMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","an","oocyte","to","attain","its","fully","functional","state",".","Oocyte","maturation","commences","after","reinitiation","of","meiosis","commonly","starting","with","germinal","vesicle","breakdown",",","and","continues","up","to","the","second","meiotic","arrest","prior","to","fertilization","."),3981030). assertion_content_comment('tOboGo_OocyteMicrotubuleCytoskeletonOrganization',s("Formation","and","maintenance","of","a","polarized","microtubule","array","originating","from","a","microtubule-organizing","center","(","MTOC",")","in","the","oocyte",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4015099). assertion_content_comment('tOboGo_OocyteMicrotubuleCytoskeletonPolarization',s("Establishment","and","maintenance","of","a","specific","axis","of","polarity","of","the","oocyte","microtubule","network",".","The","axis","is","set","so","that","the","minus","and","plus","ends","of","the","microtubules","of","the","mid","stage","oocyte","are","positioned","along","the","anterior","cortex","and","at","the","posterior","pole",",","respectively",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4015126). assertion_content_comment('tOboGo_OocyteMorphogenesis',s("The","process","in","which","the","structures","of","an","oocyte","are","generated","and","organized",".","This","process","occurs","while","the","initially","relatively","unspecialized","cell","is","acquiring","the","specialized","features","of","an","oocyte","."),4106422). assertion_content_comment('tOboGo_OocyteNucleusLocalizationInvolvedInOocyteDorsalVentralAxisSpecification',s("The","directed","movement","of","the","nucleus","to","a","specific","location","within","a","cell","during","the","establishment","and","maintenance","of","the","dorsal/ventral","axis","of","the","oocyte","."),4052035). assertion_content_comment('tOboGo_OocyteNucleusMigrationInvolvedInOocyteDorsalVentralAxisSpecification',s("The","directed","movement","of","the","oocyte","nucleus","within","the","cell","as","part","of","the","establishment","and","maintenance","of","the","dorsal/ventral","axis","of","the","oocyte",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4235839). assertion_content_comment('tOboGo_OogenesisStage',s("A","reproductive","process","that","is","a","step","in","the","formation","and","maturation","of","an","ovum","or","female","gamete","from","a","primordial","female","germ","cell","."),3981230). assertion_content_comment('tOboGo_Oogenesis',s("The","complete","process","of","formation","and","maturation","of","an","ovum","or","female","gamete","from","a","primordial","female","germ","cell",".","Examples","of","this","process","are","found","in","Mus","musculus","and","Drosophila","melanogaster","."),3980987). assertion_content_comment('tOboGo_OogoniumDevelopment',s("The","process","that","leads","to","the","development","of","an","oogonium",",","a","female","gametangium","of","Oomycetes",",","containing","one","or","more","gametes","."),4148455). assertion_content_comment('tOboGo_OogoniumStage',s("The","stage","in","mammalian","oogenesis","when","the","primordial","germ","cell","is","hardly","distinguishable","from","other","cortical","cells","of","the","ovary","."),4385173). assertion_content_comment('tOboGo_OomyceteSporangiumDevelopment',s("The","process","that","leads","to","the","development","of","an","oomycete","sporangium",",","a","single-celled","or","many-celled","structure","that","germinates","directly","to","form","an","infection","hypha","or","differentiates",",","through","specialized","cleavage","vesicles",",","into","between","10","and","30","zoospores",",","which","are","laterally","flagellated","."),4147963). assertion_content_comment('tOboGo_OosporeFormation',s("The","process","in","which","male","and","female","gametangia","develop","and","fuse","to","form","an","oospore",",","a","thick-walled","resting","spore","of","oomycetes","."),4148624). assertion_content_comment('tOboGo_OpenRectifierPotassiumChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","potassium","ion","by","an","open","rectifier","voltage-gated","channel",".","An","open","rectifier","current-voltage","relationship","is","one","in","which","the","direction","of","rectification","depends","on","the","external","potassium","ion","concentration","."),4217891). assertion_content_comment('tOboGo_OpenTrachealSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","open","tracheal","system","over","time",",","from","its","formation","to","the","mature","structure",".","An","open","tracheal","system","is","a","respiratory","system",",","a","branched","network","of","epithelial","tubes","that","supplies","oxygen","to","target","tissues","via","spiracles",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4017387). assertion_content_comment('tOboGo_OperantConditioning',s("Learning","to","anticipate","future","events","on","the","basis","of","past","experience","with","the","consequences","of","one","'","s","own","behavior","."),4381937). assertion_content_comment('tOboGo_OphelineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","guanidinoethyl","methyl","phosphate","=","N","'","-phosphoguanidinoethyl","methylphosphate","+","ADP","+","2","H","(","+",")"),4271324). assertion_content_comment('tOboGo_OpineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","2S",")","-2-","[","(","R",")","-1-carboxyethylamino","]","pentanoate","+","H","(","2",")","O","+","NAD","(","+",")","=","L-2-aminopentanoate","+","H","(","+",")","+","NADH","+","pyruvate","."),4365768). assertion_content_comment('tOboGo_OpioidPeptideActivity',s("Naturally","occurring","peptide","that","is","an","opioid","(","any","non-alkaloid","having","an","opiate-like","effect","that","can","be","reversed","by","naloxone","or","other","recognized","morphine","antagonist",")","These","include","Leu-","and","Met-enkephalin",",","dynorphin","and","neoendorphin",",","alpha",",","beta",",","gamma","and","delta","endorphins","formed","from","beta-lipotropin",",","various","pronase-resistant","peptides","such","as","beta","casamorphin",",","and","other","peptides","whose","opiate-like","action","seems","to","be","indirect","."),4361491). assertion_content_comment('tOboGo_OpioidReceptorActivity',s("Combining","with","an","opioid",",","any","narcotic","derived","from","or","resembling","opium",",","to","initiate","a","change","in","cell","activity","."),4198885). assertion_content_comment('tOboGo_OpioidReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","opioid","receptor","."),4322317). assertion_content_comment('tOboGo_OpioidReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","opioid","receptor","binding","to","one","of","its","physiological","ligands","."),3973461). assertion_content_comment('tOboGo_OpsinBinding',s("Interacting","selectively","and","non-covalently","with","an","opsin",",","any","of","a","group","of","hydrophobic",",","integral","membrane","glycoproteins","located","primarily","in","the","disc","membrane","of","rods","or","cones",",","involved","in","photoreception","."),4302649). assertion_content_comment('tOboGo_Opsin',s("OBSOLETE",".","Hydrophobic","glycoprotein","to","which","11-cis-retinal","binds","as","a","Schiff","base","(","in","rhodopsin",")","or","3",",","4-didehydro-11-cis-retinal","binds","as","a","Schiff","base","in","cyanopsin","and","porphyropsin","."),4297268). assertion_content_comment('tOboGo_OpsoninActivity',s("OBSOLETE",".","Binds","to","microorganisms","or","other","particulate","material","(","for","example",",","foreign","erythrocytes",")","to","increase","the","susceptibility","of","the","latter","to","phagocytosis","."),4255820). assertion_content_comment('tOboGo_OpsoninBinding',s("Interacting","selectively","and","non-covalently","with","an","opsonin",",","such","as","a","complement","component","or","antibody",",","deposited","on","the","surface","of","a","bacteria",",","virus",",","immune","complex",",","or","other","particulate","material","."),4200463). assertion_content_comment('tOboGo_OpsoninReceptorActivity',s("Combining","with","an","opsonin","to","initiate","a","change","in","cell","activity","."),4200466). assertion_content_comment('tOboGo_Opsonization',s("The","process","in","which","a","microorganism","(","or","other","particulate","material",")","is","rendered","more","susceptible","to","phagocytosis","by","coating","with","an","opsonin",",","a","blood","serum","protein","such","as","a","complement","component","or","antibody","."),4016032). assertion_content_comment('tOboGo_OpticChiasmaDevelopment',s("The","developmental","process","pertaining","to","the","progression","of","the","optic","chiasm","from","its","initial","formation","to","the","mature","structure",".","The","process","begins","when","the","pathfinding","of","the","axons","of","the","developing","optic","nerve","cause","some","axons","to","cross","at","the","midline","of","the","brain","and","ends","when","the","axons","are","mature","."),4133733). assertion_content_comment('tOboGo_OpticCupStructuralOrganization',s("The","process","that","contributes","to","creating","the","structural","organization","of","the","optic","cup",".","This","process","pertains","to","the","physical","shaping","of","the","rudimentary","structure","."),4004547). assertion_content_comment('tOboGo_OpticLobePlacodeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","optic","placode","over","time",",","from","its","formation","to","the","mature","structure",".","During","embryonic","stage","12","the","placode","starts","to","invaginate",",","forming","a","pouch",".","Cells","that","will","form","Bolwig","'","s","organ","segregate","from","the","ventral","lip","of","this","pouch",",","remaining","in","the","head","epidermis",".","The","remainder","of","the","invagination","loses","contact","with","the","outer","surface","and","becomes","the","optic","lobe",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),3985307). assertion_content_comment('tOboGo_OpticLobePlacodeFormation',s("Establishment","of","the","optic","placode",",","a","thickened","area","of","densely","packed","ectoderm","cells","directly","overlying","the","optic","vesicle","in","the","early","embryo",".","In","Drosophila",",","for","example",",","the","placode","appears","in","the","dorsolateral","region","of","the","head","in","late","stage","11","embryos","and","is","the","precursor","to","the","larval","visual","system","."),3985320). assertion_content_comment('tOboGo_OpticNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","optic","nerve","over","time",",","from","its","formation","to","the","mature","structure",".","The","sensory","optic","nerve","originates","from","the","bipolar","cells","of","the","retina","and","conducts","visual","information","to","the","brainstem",".","The","optic","nerve","exits","the","back","of","the","eye","in","the","orbit",",","enters","the","optic","canal",",","and","enters","the","central","nervous","system","at","the","optic","chiasm","(","crossing",")","where","the","nerve","fibers","become","the","optic","tract","just","prior","to","entering","the","hindbrain","."),4044483). assertion_content_comment('tOboGo_OpticNerveFormation',s("The","process","that","gives","rise","to","the","optic","nerve",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","sensory","optic","nerve","originates","from","the","bipolar","cells","of","the","retina","and","conducts","visual","information","to","the","brainstem",".","The","optic","nerve","exits","the","back","of","the","eye","in","the","orbit",",","enters","the","optic","canal",",","and","enters","the","central","nervous","system","at","the","optic","chiasm","(","crossing",")","where","the","nerve","fibers","become","the","optic","tract","just","prior","to","entering","the","hindbrain","."),4044561). assertion_content_comment('tOboGo_OpticNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","optic","nerve","to","attain","its","fully","functional","state",".","The","sensory","optic","nerve","originates","from","the","bipolar","cells","of","the","retina","and","conducts","visual","information","to","the","brainstem",".","The","optic","nerve","exits","the","back","of","the","eye","in","the","orbit",",","enters","the","optic","canal",",","and","enters","the","central","nervous","system","at","the","optic","chiasm","(","crossing",")","where","the","nerve","fibers","become","the","optic","tract","just","prior","to","entering","the","hindbrain","."),4044512). assertion_content_comment('tOboGo_OpticNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","optic","nerve","is","generated","and","organized",".","The","sensory","optic","nerve","originates","from","the","bipolar","cells","of","the","retina","and","conducts","visual","information","to","the","brainstem",".","The","optic","nerve","exits","the","back","of","the","eye","in","the","orbit",",","enters","the","optic","canal",",","and","enters","the","central","nervous","system","at","the","optic","chiasm","(","crossing",")","where","the","nerve","fibers","become","the","optic","tract","just","prior","to","entering","the","hindbrain","."),4044488). assertion_content_comment('tOboGo_OpticNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","optic","nerve",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","sensory","optic","nerve","originates","from","the","bipolar","cells","of","the","retina","and","conducts","visual","information","to","the","brainstem",".","The","optic","nerve","exits","the","back","of","the","eye","in","the","orbit",",","enters","the","optic","canal",",","and","enters","the","central","nervous","system","at","the","optic","chiasm","(","crossing",")","where","the","nerve","fibers","become","the","optic","tract","just","prior","to","entering","the","hindbrain","."),4044500). assertion_content_comment('tOboGo_OpticPlacodeFormation',s("The","initial","developmental","process","that","will","lead","to","the","formation","of","an","eye","."),3985297). assertion_content_comment('tOboGo_OpticVesicleElongation',s("The","developmental","growth","that","results","in","the","lengthening","of","the","optic","vesicle","in","the","posterior","direction","."),4004628). assertion_content_comment('tOboGo_OpticVesicleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","optic","vesicle","from","the","lateral","wall","of","the","forebrain",".","This","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","vesicle","and","ends","when","the","vesicle","has","evaginated",".","The","optic","vesicle","is","the","evagination","of","neurectoderm","that","precedes","formation","of","the","optic","cup","."),4004598). assertion_content_comment('tOboGo_OpticVesicleMorphogenesis',s("The","developmental","process","pertaining","to","the","formation","and","shaping","of","the","optic","vesicle",".","This","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","vesicle","and","ends","when","the","vesicle","has","evaginated",".","The","optic","vesicle","is","the","evagination","of","neurectoderm","that","precedes","formation","of","the","optic","cup","."),4004595). assertion_content_comment('tOboGo_OptokineticBehavior',s("The","actions","or","reactions","of","an","organism","pertaining","to","movement","of","the","eyes","and","of","objects","in","the","visual","field",",","as","in","nystagmus","."),4172777). assertion_content_comment('tOboGo_OptomotorResponse',s("Eye",",","head","or","whole","body","movements","that","help","to","compensate","movements","of","the","environment","in","order","to","stabilize","its","image","on","the","retina",".","In","the","case","of","whole","body","movements",",","these","motor","actions","may","also","stabilize","a","locomotor","course","in","response","to","some","disturbance",".","Examples","include",":","the","optokinetic","reflex",",","which","allows","human","eyes","to","follow","objects","in","motion","while","the","head","remains","stationary","reflex",";","the","optomotor","responses","of","flying","insects","and","swimming","fish","."),4172780). assertion_content_comment('tOboGo_OralAboralAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","a","line","that","delineates","the","mouth","and","the","anus","of","an","embryo","."),4113688). assertion_content_comment('tOboGo_OralApparatusOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","oral","apparatus",".","The","oral","apparatus","is","a","funnel-like","structure","used","by","the","cell","to","collect","food","and","channel","it","to","the","cytostome",",","characteristic","of","ciliate","protozoans","."),4329259). assertion_content_comment('tOboGo_OralApparatus',s("Complex","basket-","or","funnel-like","structure","used","by","the","cell","to","collect","food","and","channel","it","to","the","cytostome",";","includes","specialized","sub-structures","made","up","of","closely-spaced","cilia","and","underlying","basal","bodies","and","fibrillar","systems","."),4055012). assertion_content_comment('tOboGo_OralIncubation',s("A","parental","behavior","in","which","fertilized","eggs","are","taken","into","the","mouth","and","held","until","hatching","."),4161106). assertion_content_comment('tOboGo_OrbitofrontalCortexDevelopment',s("The","progression","of","the","orbitofrontal","cortex","over","time","from","its","initial","formation","until","its","mature","state",".","The","orbitofrontal","cortex","is","a","cerebral","cortex","region","located","in","the","frontal","lobe","."),4049343). assertion_content_comment('tOboGo_OrcinolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","orcinol","(","5-methyl-1",",","3-benzenediol",")",",","an","aromatic","compound","derived","from","the","fermentation","of","lichen","and","synthesized","by","some","higher","plants","."),4351761). assertion_content_comment('tOboGo_OrcinolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","orcinol","(","5-methyl-1",",","3-benzenediol",")",",","an","aromatic","compound","derived","from","the","fermentation","of","lichen","and","synthesized","by","some","higher","plants","."),4314423). assertion_content_comment('tOboGo_OrcinolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","orcinol","(","5-methyl-1",",","3-benzenediol",")",",","an","aromatic","compound","derived","from","the","fermentation","of","lichen",",","and","synthesized",",","probably","as","a","fungicide",",","by","some","higher","plants","."),4272716). assertion_content_comment('tOboGo_OrexigenicNeuropeptideQRFPReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","orexigenic","neuropeptide","QRFP","receptor","."),4324093). assertion_content_comment('tOboGo_OrexinReceptorActivity',s("Combining","with","orexin","to","initiate","a","change","in","cell","activity","."),4305033). assertion_content_comment('tOboGo_OrganBoundarySpecificationBetweenLateralOrgansAndTheMeristem',s("The","process","in","which","boundaries","between","lateral","organs","and","the","meristem","is","established","and","maintained","."),4333896). assertion_content_comment('tOboGo_OrganDevelopment',s("Development","of","a","tissue","or","tissues","that","work","together","to","perform","a","specific","function","or","functions",".","Development","pertains","to","the","process","whose","specific","outcome","is","the","progression","of","a","structure","over","time",",","from","its","formation","to","the","mature","structure",".","Organs","are","commonly","observed","as","visibly","distinct","structures",",","but","may","also","exist","as","loosely","associated","clusters","of","cells","that","work","together","to","perform","a","specific","function","or","functions","."),3978761). assertion_content_comment('tOboGo_OrganellarChromatophoreInnerMembrane',s("The","inner",",","i.e",".","lumen-facing",",","of","the","two","lipid","bilayers","surrounding","an","organellar","chromatophore","."),4179912). assertion_content_comment('tOboGo_OrganellarChromatophoreIntermembraneSpace',s("The","region","between","the","inner","and","outer","lipid","bilayers","that","surround","an","organellar","chromatophore","."),4133253). assertion_content_comment('tOboGo_OrganellarChromatophoreMembrane',s("Either","of","the","lipid","bilayers","that","surround","an","organellar","chromatophore","."),4133276). assertion_content_comment('tOboGo_OrganellarChromatophoreOuterMembrane',s("The","outer",",","i.e",".","cytoplasm-facing",",","of","the","two","lipid","bilayers","surrounding","an","organellar","chromatophore","."),4179923). assertion_content_comment('tOboGo_OrganellarChromatophore',s("A","bacteroid-containing","symbiosome","in","which","the","bacterial","component","is","a","genetically","highly","reduced","cyanobacterium","that","is","photosynthetically","active","and","incapable","of","an","independent","existence","outside","its","host",".","The","chromatophore","functions","as","a","photosynthetic","organelle",",","and","has","been","found","and","characterized","in","the","amoeba","Paulinella","chromatophora","."),4133228). assertion_content_comment('tOboGo_OrganellarChromatophoreThylakoidLumen',s("The","volume","enclosed","by","an","organellar","chromatophore","thylakoid","membrane","."),4133288). assertion_content_comment('tOboGo_OrganellarChromatophoreThylakoidMembrane',s("The","lipid","bilayer","membrane","of","any","thylakoid","within","an","organellar","chromatophore","."),4133300). assertion_content_comment('tOboGo_OrganellarChromatophoreThylakoid',s("A","thylakoid","located","in","an","organellar","chromatophore","."),4133241). assertion_content_comment('tOboGo_OrganellarLargeRibosomalSubunit',s("The","larger","of","the","two","subunits","of","an","organellar","ribosome",".","Two","sites","on","the","ribosomal","large","subunit","are","involved","in","translation",":","the","aminoacyl","site","(","A","site",")","and","peptidyl","site","(","P","site",")"),3974552). assertion_content_comment('tOboGo_OrganellarRibosome',s("A","ribosome","contained","within","a","subcellular","membrane-bounded","organelle","."),3974455). assertion_content_comment('tOboGo_OrganellarSmallRibosomalSubunit',s("The","smaller","of","the","two","subunits","of","an","organellar","ribosome","."),3974525). assertion_content_comment('tOboGo_OrganelleAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","organelle",".","An","organelle","is","an","organized","structure","of","distinctive","morphology","and","function",".","Includes","the","nucleus",",","mitochondria",",","plastids",",","vacuoles",",","vesicles",",","ribosomes","and","the","cytoskeleton",".","Excludes","the","plasma","membrane","."),3969568). assertion_content_comment('tOboGo_OrganelleEnvelopeLumen',s("The","region","between","the","inner","and","outer","lipid","bilayers","of","an","organelle","envelope","."),4006567). assertion_content_comment('tOboGo_OrganelleEnvelope',s("A","double","membrane","structure","enclosing","an","organelle",",","including","two","lipid","bilayers","and","the","region","between","them",".","In","some","cases",",","an","organelle","envelope","may","have","more","than","two","membranes","."),3974083). assertion_content_comment('tOboGo_OrganelleFission',s("The","creation","of","two","or","more","organelles","by","division","of","one","organelle","."),3970429). assertion_content_comment('tOboGo_OrganelleFusion',s("The","creation","of","a","single","organelle","from","two","or","more","organelles","."),3969839). assertion_content_comment('tOboGo_OrganelleInheritance',s("The","partitioning","of","organelles","between","daughter","cells","at","cell","division","."),4077146). assertion_content_comment('tOboGo_OrganelleInnerMembrane',s("The","inner",",","i.e",".","lumen-facing",",","lipid","bilayer","of","an","organelle","envelope",";","usually","highly","selective","to","most","ions","and","metabolites","."),3974127). assertion_content_comment('tOboGo_OrganelleLocalization',s("Any","process","in","which","an","organelle","is","transported","to",",","and/or","maintained","in",",","a","specific","location","."),3970022). assertion_content_comment('tOboGo_OrganelleLumen',s("The","internal","volume","enclosed","by","the","membranes","of","a","particular","organelle",";","includes","the","volume","enclosed","by","a","single","organelle","membrane",",","e.g",".","endoplasmic","reticulum","lumen",",","or","the","volume","enclosed","by","the","innermost","of","the","two","lipid","bilayers","of","an","organelle","envelope",",","e.g",".","nuclear","lumen","."),3972752). assertion_content_comment('tOboGo_OrganelleMembraneContactSite',s("A","zone","of","apposition","between","the","membranes","of","two","organelles",",","structured","by","bridging","complexes",".","Membrane","contact","sites","(","MCSs",")","are","specialized","for","communication",",","including","the","efficient","traffic","of","small","molecules","such","as","Ca2","+","ions","and","lipids",",","as","well","as","enzyme-substrate","interactions","."),4070096). assertion_content_comment('tOboGo_OrganelleMembraneFusion',s("The","joining","of","two","lipid","bilayers","to","form","a","single","organelle","membrane","."),3969893). assertion_content_comment('tOboGo_OrganelleMembrane',s("The","lipid","bilayer","surrounding","an","organelle","."),3972012). assertion_content_comment('tOboGo_OrganelleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","organelle","within","a","cell",".","An","organelle","is","an","organized","structure","of","distinctive","morphology","and","function",".","Includes","the","nucleus",",","mitochondria",",","plastids",",","vacuoles",",","vesicles",",","ribosomes","and","the","cytoskeleton",".","Excludes","the","plasma","membrane","."),3969245). assertion_content_comment('tOboGo_OrganelleOuterMembrane',s("The","outer",",","i.e",".","cytoplasm-facing","in","a","cellular","organelle",",","lipid","bilayer","of","an","organelle","envelope","."),3980244). assertion_content_comment('tOboGo_OrganellePart',s("Any","constituent","part","of","an","organelle",",","an","organized","structure","of","distinctive","morphology","and","function",".","Includes","constituent","parts","of","the","nucleus",",","mitochondria",",","plastids",",","vacuoles",",","vesicles",",","ribosomes","and","the","cytoskeleton",",","but","excludes","the","plasma","membrane","."),3971754). assertion_content_comment('tOboGo_Organelle',s("Organized","structure","of","distinctive","morphology","and","function",".","Includes","the","nucleus",",","mitochondria",",","plastids",",","vacuoles",",","vesicles",",","ribosomes","and","the","cytoskeleton",",","and","prokaryotic","structures","such","as","anammoxosomes","and","pirellulosomes",".","Excludes","the","plasma","membrane","."),3971752). assertion_content_comment('tOboGo_OrganelleSubcompartment',s("A","compartment","that","consists","of","a","lumen","and","an","enclosing","membrane",",","and","is","part","of","an","organelle","."),3971883). assertion_content_comment('tOboGo_OrganelleTransportAlongMicrotubule',s("The","directed","movement","of","an","organelle","along","a","microtubule",",","mediated","by","motor","proteins",".","This","process","begins","with","the","attachment","of","an","organelle","to","a","microtubule",",","and","ends","when","the","organelle","reaches","its","final","destination","."),3977916). assertion_content_comment('tOboGo_OrganFormation',s("The","process","pertaining","to","the","initial","formation","of","an","organ","from","unspecified","parts",".","The","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","discrete","structure",",","such","as","inductive","events",",","and","ends","when","the","structural","rudiment","of","the","organ","is","recognizable",",","such","as","a","condensation","of","mesenchymal","cells","into","the","organ","rudiment",".","Organs","are","a","natural","part","or","structure","in","an","animal","or","a","plant",",","capable","of","performing","some","special","action","(","termed","its","function",")",",","which","is","essential","to","the","life","or","well-being","of","the","whole",".","The","heart","and","lungs","are","organs","of","animals",",","and","the","petal","and","leaf","are","organs","of","plants",".","In","animals","the","organs","are","generally","made","up","of","several","tissues",",","one","of","which","usually","predominates",",","and","determines","the","principal","function","of","the","organ","."),3985424). assertion_content_comment('tOboGo_OrganGrowth',s("The","increase","in","size","or","mass","of","an","organ",".","Organs","are","commonly","observed","as","visibly","distinct","structures",",","but","may","also","exist","as","loosely","associated","clusters","of","cells","that","function","together","as","to","perform","a","specific","function","."),4001733). assertion_content_comment('tOboGo_OrganicAcidBinding',s("Interacting","selectively","and","non-covalently","with","an","organic","acid",",","any","acidic","compound","containing","carbon","in","covalent","linkage","."),4317293). assertion_content_comment('tOboGo_OrganicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","organic","acids",",","any","acidic","compound","containing","carbon","in","covalent","linkage","."),4014438). assertion_content_comment('tOboGo_OrganicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","organic","acids",",","any","acidic","compound","containing","carbon","in","covalent","linkage","."),4057908). assertion_content_comment('tOboGo_OrganicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organic","acids",",","any","acidic","compound","containing","carbon","in","covalent","linkage","."),3978956). assertion_content_comment('tOboGo_OrganicAcidPhosphorylation',s("The","process","of","introducing","one","or","more","phosphate","groups","into","an","organic","acid","."),4319822). assertion_content_comment('tOboGo_OrganicAcid_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","organic","acid","(","out",")","+","Na","+","(","out",")","=","organic","acid","(","in",")","+","Na","+","(","in",")"),4215629). assertion_content_comment('tOboGo_OrganicAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","organic","acids",",","any","acidic","compound","containing","carbon","in","covalent","linkage",",","from","one","side","of","the","membrane","to","the","other","."),4158507). assertion_content_comment('tOboGo_OrganicAcidTransport',s("The","directed","movement","of","organic","acids",",","any","acidic","compound","containing","carbon","in","covalent","linkage",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990602). assertion_content_comment('tOboGo_OrganicAlcoholTransport',s("The","directed","movement","of","organic","alcohols","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","An","organic","alcohol","is","any","carbon-containing","compound","containing","a","hydroxyl","group","."),4026629). assertion_content_comment('tOboGo_OrganicAnionChannelActivity',"OBSOLETE.",4295399). assertion_content_comment('tOboGo_OrganicAnionTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","organic","anions","from","one","side","of","a","membrane","to","the","other",".","Organic","anions","are","atoms","or","small","molecules","with","a","negative","charge","which","contain","carbon","in","covalent","linkage","."),4254585). assertion_content_comment('tOboGo_OrganicAnionTransport',s("The","directed","movement","of","organic","anions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Organic","anions","are","atoms","or","small","molecules","with","a","negative","charge","which","contain","carbon","in","covalent","linkage","."),3990532). assertion_content_comment('tOboGo_OrganicCationTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","organic","cations","from","one","side","of","a","membrane","to","the","other",".","Organic","cations","are","atoms","or","small","molecules","with","a","positive","charge","that","contain","carbon","in","covalent","linkage","."),4254572). assertion_content_comment('tOboGo_OrganicCationTransport',s("The","directed","movement","of","organic","cations","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Organic","cations","are","atoms","or","small","molecules","with","a","positive","charge","which","contain","carbon","in","covalent","linkage","."),4156576). assertion_content_comment('tOboGo_OrganicEtherMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organic","ethers",",","any","anhydride","of","the","general","formula","R1-O-R2",",","formed","between","two","identical","or","nonidentical","organic","hydroxy","compounds","."),4036942). assertion_content_comment('tOboGo_OrganicSubstanceMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organic","substances",",","any","molecular","entities","containing","carbon","."),4044997). assertion_content_comment('tOboGo_OrganicSubstanceTransport',s("The","directed","movement","of","organic","substances","into",",","out","of","or","within","a","cell",",","or","between","cells",",","or","within","a","multicellular","organism","by","means","of","some","agent","such","as","a","transporter","or","pore",".","An","organic","substance","is","a","molecular","entity","that","contains","carbon","."),3990569). assertion_content_comment('tOboGo_OrganInduction',s("The","interaction","of","two","or","more","cells","or","tissues","that","causes","them","to","change","their","fates","and","specify","the","development","of","an","organ","."),3985536). assertion_content_comment('tOboGo_OrganismEmergenceFromProtectiveStructure',s("The","developmental","process","in","which","an","organism","emerges","from","a","surrounding","protective","structure","such","as","an","egg","or","pupa","case","."),3987111). assertion_content_comment('tOboGo_OrganMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","an","organ","to","attain","its","fully","functional","state",".","An","organ","is","a","tissue","or","set","of","tissues","that","work","together","to","perform","a","specific","function","or","functions","."),4081244). assertion_content_comment('tOboGo_OrganMorphogenesis',s("Morphogenesis","of","an","organ",".","An","organ","is","defined","as","a","tissue","or","set","of","tissues","that","work","together","to","perform","a","specific","function","or","functions",".","Morphogenesis","is","the","process","in","which","anatomical","structures","are","generated","and","organized",".","Organs","are","commonly","observed","as","visibly","distinct","structures",",","but","may","also","exist","as","loosely","associated","clusters","of","cells","that","work","together","to","perform","a","specific","function","or","functions","."),3981771). assertion_content_comment('tOboGo_OrganomercurialTransporterActivity',s("Enables","the","directed","movement","of","organomercurial","compounds","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Organomercurial","substances","are","any","organic","compound","containing","a","mercury","atom","."),4293024). assertion_content_comment('tOboGo_OrganomercurialTransport',s("The","directed","movement","of","organomercurial","compounds","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Organomercurial","substances","are","any","organic","compound","containing","a","mercury","atom","."),4294176). assertion_content_comment('tOboGo_OrganomercuryBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","organomercury","compounds",",","any","organic","compound","containing","a","mercury","atom","."),4313542). assertion_content_comment('tOboGo_OrganomercuryCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","organomercury","compounds",",","any","organic","compound","containing","a","mercury","atom","."),4242690). assertion_content_comment('tOboGo_OrganomercuryMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organomercury","compound",",","any","organic","compound","containing","a","mercury","atom","."),4242673). assertion_content_comment('tOboGo_OrganometalMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organometals",",","any","metal-containing","organic","compound",",","especially","one","in","which","the","metal","atom","is","linked","directly","to","one","of","more","carbon","atoms","."),4242670). assertion_content_comment('tOboGo_OrganophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","biosynthesis","of","deoxyribose","phosphate",",","the","phosphorylated","sugar","2-deoxy-erythro-pentose","."),4034814). assertion_content_comment('tOboGo_OrganophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","organophosphates",",","any","phosphate-containing","organic","compound","."),4038139). assertion_content_comment('tOboGo_OrganophosphateEsterTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","organophosphate","esters","from","one","side","of","a","membrane","to","the","other",".","Organophosphate","esters","are","small","organic","molecules","containing","phosphate","ester","bonds","."),4289475). assertion_content_comment('tOboGo_OrganophosphateEsterTransport',s("The","directed","movement","of","organophosphate","esters","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Organophosphate","esters","are","small","organic","molecules","containing","phosphate","ester","bonds","."),4291111). assertion_content_comment('tOboGo_Organophosphate_InorganicPhosphateAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","organophosphate","(","out",")","+","inorganic","phosphate","(","in",")","=","organophosphate","(","in",")","+","inorganic","phosphate","(","out",")"),4020541). assertion_content_comment('tOboGo_OrganophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organophosphates",",","any","phosphate-containing","organic","compound","."),4009889). assertion_content_comment('tOboGo_OrganophosphorusResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4246037). assertion_content_comment('tOboGo_OrganophosphorusSusceptibilityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4304436). assertion_content_comment('tOboGo_OrganOrTissueSpecificImmuneResponse',s("An","immune","response","taking","place","in","an","organ","or","tissues","such","as","the","liver",",","brain",",","mucosa",",","or","nervous","system","tissues","."),3993405). assertion_content_comment('tOboGo_OrganosiliconCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","organosilicons",",","any","organic","compound","that","contains","silicon","."),4314340). assertion_content_comment('tOboGo_OrganosiliconMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","organosilicon",",","organic","compounds","that","contain","silicon",",","a","nonmetal","element","analogous","to","carbon","."),4272650). assertion_content_comment('tOboGo_OrganosulfideCycle',s("A","cyclic","series","of","interconversions","involving","dimethyl","sulfide",",","methanethiol","and","hydrogen","sulfide",".","Dimethylsulfoxide","can","also","be","converted","to","dimethyl","sulfide",",","which","enters","the","cycle","."),4272404). assertion_content_comment('tOboGo_OrganotinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organotin",",","an","organic","compound","containing","a","tin","atom","."),4272700). assertion_content_comment('tOboGo_OrganRegeneration',s("The","regrowth","of","a","lost","or","destroyed","organ","."),4318850). assertion_content_comment('tOboGo_OrganSenescence',s("The","process","that","occurs","in","an","organ","near","the","end","of","its","active","life","that","is","associated","with","the","dismantling","of","cell","components","and","membranes",",","and","an","overall","decline","in","metabolism",".","An","example","of","this","process","is","found","in","Arabidopsis","thaliana","."),4031820). assertion_content_comment('tOboGo_OriginRecognitionComplex',s("A","multisubunit","complex","that","is","located","at","the","replication","origins","of","a","chromosome","."),3978293). assertion_content_comment('tOboGo_OrnithineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ornithine",",","an","amino","acid","only","rarely","found","in","proteins",",","but","which","is","important","in","living","organisms","as","an","intermediate","in","the","reactions","of","the","urea","cycle","and","in","arginine","biosynthesis","."),4232054). assertion_content_comment('tOboGo_OrnithineCarbamoyltransferaseActivity',s("Catalysis","of","the","reaction",":","carbamoyl","phosphate","+","L-ornithine","=","phosphate","+","L-citrulline","."),4204120). assertion_content_comment('tOboGo_OrnithineCarbamoyltransferaseComplex',s("A","homotrimeric","protein","complex","that","catalyzes","the","transfer","of","a","carbamoyl","group","to","ornithine",",","forming","citrulline","."),4259615). assertion_content_comment('tOboGo_OrnithineCarbamoyltransferaseInhibitorActivity',s("Stops",",","prevents",",","or","reduces","ornithine","carbamoyltransferase","activity",",","the","catalysis","of","the","reaction",":","carbamoyl","phosphate","+","L-ornithine","=","phosphate","+","L-citrulline","."),4155313). assertion_content_comment('tOboGo_OrnithineCatabolicProcessByDecarboxylation',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ornithine","by","decarboxylation","."),4241524). assertion_content_comment('tOboGo_OrnithineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ornithine",",","an","amino","acid","only","rarely","found","in","proteins",",","but","which","is","important","in","living","organisms","as","an","intermediate","in","the","reactions","of","the","urea","cycle","and","in","arginine","biosynthesis","."),4232069). assertion_content_comment('tOboGo_OrnithineCatabolicProcessViaProline',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ornithine",",","via","the","intermediate","proline","."),4241477). assertion_content_comment('tOboGo_OrnithineCyclodeaminaseActivity',s("Catalysis","of","the","reaction",":","L-ornithine","=","L-proline","+","NH","(","4",")","(","+",")"),4254205). assertion_content_comment('tOboGo_OrnithineDecarboxylaseActivatorActivity',s("Upregulation","of","the","activity","of","the","enzyme","ornithine","decarboxylase","."),4316124). assertion_content_comment('tOboGo_OrnithineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","L-ornithine","+","H","(","+",")","=","CO","(","2",")","+","putrescine","."),4204264). assertion_content_comment('tOboGo_OrnithineDecarboxylaseInhibitorActivity',s("The","stopping",",","prevention","or","reduction","of","the","activity","of","the","enzyme","ornithine","decarboxylase","."),4247251). assertion_content_comment('tOboGo_OrnithineDecarboxylaseRegulatorActivity',s("Modulation","of","the","activity","of","the","enzyme","ornithine","decarboxylase","."),4247249). assertion_content_comment('tOboGo_OrnithineLysineTransaminaseActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","L-ornithine","=","H2O","+","L-glutamate","+","3",",","4-dihydro-2H-pyrrole-2-carboxylate","."),4271334). assertion_content_comment('tOboGo_OrnithineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ornithine",",","an","amino","acid","only","rarely","found","in","proteins",",","but","which","is","important","in","living","organisms","as","an","intermediate","in","the","reactions","of","the","urea","cycle","and","in","arginine","biosynthesis","."),4139267). assertion_content_comment('tOboGo_OrnithineRacemaseActivity',s("Catalysis","of","the","reaction",":","L-ornithine","=","D-ornithine","."),4271279). assertion_content_comment('tOboGo_OrnithineTransport',s("The","directed","movement","of","ornithine",",","2",",","5-diaminopentanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293750). assertion_content_comment('tOboGo_OrotatePhosphoribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","orotidine","5","'","-phosphate","+","diphosphate","=","orotate","+","5-phospho-alpha-D-ribose","1-diphosphate","."),4204208). assertion_content_comment('tOboGo_OrotateReductaseNADHActivity',s("Catalysis","of","the","reaction",":","(","S",")","-dihydroorotate","+","NAD","(","+",")","=","H","(","+",")","+","NADH","+","orotate","."),4204197). assertion_content_comment('tOboGo_OrotateReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","(","S",")","-dihydroorotate","+","NADP","(","+",")","=","H","(","+",")","+","NADPH","+","orotate","."),4271310). assertion_content_comment('tOboGo_OrsellinateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","o-orsellinate","+","H","(","+",")","=","CO","(","2",")","+","orcinol","."),4271299). assertion_content_comment('tOboGo_OrthodenticleMRNALocalization',s("Any","process","in","which","orthodenticle","mRNA","is","transported","to","and","maintained","in","the","oocyte","and/or","syncytial","embryo","as","part","of","the","process","that","will","specify","the","anterior/posterior","axis","."),4156334). assertion_content_comment('tOboGo_OrthogonalDichotomousSubdivisionOfTerminalUnitsInvolvedInLungBranchingMorphogenesis',s("The","process","in","which","a","lung","bud","bifurcates","perpendicular","to","the","plane","of","the","previous","bud","."),4160643). assertion_content_comment('tOboGo_Orthokinesis',s("The","movement","of","a","cell","or","organism","in","response","to","a","stimulus","in","which","the","speed","or","frequency","of","movement","is","increased","or","decreased","."),4313295). assertion_content_comment('tOboGo_OscillatoryMuscleContraction',s("A","process","in","which","force","is","generated","within","oscillatory","skeletal","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","Oscillatory","muscle","contraction","occurs","in","insect","wing","muscles","and","is","characterized","by","asynchrony","between","action","potential","and","contraction","and","by","stretch","activation","."),4320752). assertion_content_comment('tOboGo_OsmiophilicBody',s("A","membrane-bounded","vesicle","found","predominantly","in","Plasmodium","female","gametocytes",",","that","becomes","progressively","more","abundant","as","the","gametocyte","reaches","full","maturity",".","These","vesicles","lie","beneath","the","subpellicular","membrane","of","the","gametocyte",",","and","the","release","of","their","contents","into","the","parasitophorous","vacuole","has","been","postulated","to","aid","in","the","escape","of","gametocytes","from","the","erythrocyte","after","ingestion","by","the","mosquito","."),4287930). assertion_content_comment('tOboGo_OsmosensorActivity',s("Sensing","extracellular","osmolarity","to","initiate","a","change","in","cell","activity",",","and","spanning","the","membrane","of","the","cell","."),4215028). assertion_content_comment('tOboGo_OsmosensorySignalingPathway',s("The","series","of","molecular","signals","initiated","in","response","to","osmotic","change","."),3972116). assertion_content_comment('tOboGo_OsmosensorySignalingPathwayViaSho1Osmosensor',s("A","series","of","molecular","signals","generated","in","response","to","osmotic","change",",","as","mediated","through","a","Sho1","osmosensor","system","."),4235502). assertion_content_comment('tOboGo_OssificationInvolvedInBoneMaturation',s("The","formation","of","bone","or","of","a","bony","substance",",","or","the","conversion","of","fibrous","tissue","or","of","cartilage","into","bone",",","involved","in","the","progression","of","the","skeleton","from","its","formation","to","its","mature","state","."),4081976). assertion_content_comment('tOboGo_OsteoblastDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","osteoblast","over","time",",","from","its","formation","to","the","mature","structure",".","Osteoblast","development","does","not","include","the","steps","involved","in","committing","a","cranial","neural","crest","cell","or","an","osteoprogenitor","cell","to","an","osteoblast","fate",".","An","osteoblast","is","a","cell","that","gives","rise","to","bone","."),3990074). assertion_content_comment('tOboGo_OsteoblastFateCommitment',s("The","commitment","of","mesenchymal","cells","to","the","specific","cell","fate","of","an","osteoblast",".","An","osteoblast","is","a","bone-forming","cell","which","secretes","an","extracellular","matrix",".","Hydroxyapatite","crystals","are","then","deposited","into","the","matrix","to","form","bone","."),3990393). assertion_content_comment('tOboGo_OsteoclastFusion',s("The","plasma","membrane","fusion","process","that","results","in","fusion","of","mononuclear","osteoclasts","to","form","a","multinuclear","osteoclast","."),4146714). assertion_content_comment('tOboGo_OtherCollagen',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4304457). assertion_content_comment('tOboGo_OtherIsomeraseActivity',s("OBSOLETE",".","A","grouping","term","for","isomerases","that","cannot","be","more","accurately","categorized","."),4301816). assertion_content_comment('tOboGo_OtherLyaseActivity',s("OBSOLETE",".","A","grouping","term","for","lyases","that","cannot","be","more","accurately","categorized","."),4301793). assertion_content_comment('tOboGo_OtherOrganismCellMembrane',s("The","cell","membrane","of","a","secondary","organism","with","which","the","first","organism","is","interacting","."),4080861). assertion_content_comment('tOboGo_OtherOrganismCell',s("A","cell","of","a","secondary","organism","with","which","the","first","organism","is","interacting","."),4041806). assertion_content_comment('tOboGo_OtherOrganismMembrane',s("A","membrane","of","a","secondary","organism","with","which","the","first","organism","is","interacting","."),4080858). assertion_content_comment('tOboGo_OtherOrganismPart',s("Any","constituent","part","of","a","secondary","organism","with","which","the","first","organism","is","interacting","."),4041788). assertion_content_comment('tOboGo_OtherOrganismPostsynapticMembrane',s("A","postsynaptic","membrane","that","is","part","of","another","organism",",","i.e",".","a","secondary","organism","with","which","the","first","organism","is","interacting",".","A","postsynaptic","membrane","is","a","specialized","area","of","membrane","facing","the","presynaptic","membrane","on","the","tip","of","the","nerve","ending","and","separated","from","it","by","a","minute","cleft","(","the","synaptic","cleft",")","Neurotransmitters","transmit","the","signal","across","the","synaptic","cleft","to","the","postsynaptic","membrane","."),4381347). assertion_content_comment('tOboGo_OtherOrganismPresynapticMembrane',s("A","presynaptic","membrane","that","is","part","of","another","organism",",","i.e",".","a","secondary","organism","with","which","the","first","organism","is","interacting",".","A","presynaptic","membrane","is","specialized","area","of","membrane","of","the","axon","terminal","that","faces","the","plasma","membrane","of","the","neuron","or","muscle","fiber","with","which","the","axon","terminal","establishes","a","synaptic","junction",";","many","synaptic","junctions","exhibit","structural","presynaptic","characteristics",",","such","as","conical",",","electron-dense","internal","protrusions",",","that","distinguish","it","from","the","remainder","of","the","axon","plasma","membrane","."),4098034). assertion_content_comment('tOboGo_OtherOrganism',s("A","secondary","organism","with","which","the","first","organism","is","interacting","."),4041786). assertion_content_comment('tOboGo_OtherPathwaysOfElectronTransport',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228227). assertion_content_comment('tOboGo_OticPlacodeFormation',s("The","initial","developmental","process","that","will","lead","to","the","formation","of","the","vertebrate","inner","ear",".","The","otic","placode","forms","as","a","thickening","of","the","head","ectoderm","adjacent","to","the","developing","hindbrain","."),4094192). assertion_content_comment('tOboGo_OticVesicleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","otic","vesicle","over","time",",","from","its","formation","to","the","mature","structure",".","The","otic","vesicle","is","a","transient","embryonic","structure","formed","during","development","of","the","vertebrate","inner","ear","."),4061464). assertion_content_comment('tOboGo_OticVesicleFormation',s("The","process","resulting","in","the","transition","of","the","otic","placode","into","the","otic","vesicle",",","a","transient","embryonic","structure","formed","during","development","of","the","vertebrate","inner","ear","."),4061476). assertion_content_comment('tOboGo_OticVesicleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","otic","vesicle","are","generated","and","organized",".","The","otic","vesicle","is","a","transient","embryonic","structure","formed","during","development","of","the","vertebrate","inner","ear","."),4061466). assertion_content_comment('tOboGo_OtolithDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","otolith","over","time",",","from","its","formation","to","the","mature","structure","."),4005896). assertion_content_comment('tOboGo_OtolithFormation',s("The","process","that","gives","rise","to","an","otolith",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4005900). assertion_content_comment('tOboGo_OtolithMineralizationCompletedEarlyInDevelopment',s("The","formation","of","otoliths","during","embryogenesis","with","completion","in","early","postembryonic","development",".","Formation","occurs","by","precipitation","of","specific","crystal","forms","of","calcium","carbonate","around","an","organic","core","of","extracellular","matrix","proteins",".","Otoconia","(","otoliths",")","are","small","(","~","10","micron",")","dense","extracellular","particles","present","in","the","otolith","end","organs","of","the","vertebrate","inner","ear","."),4319047). assertion_content_comment('tOboGo_OtolithMineralization',s("The","precipitation","of","specific","crystal","forms","of","calcium","carbonate","with","extracellular","matrix","proteins","in","the","otolith","organs","of","the","vertebrate","inner","ear","."),4085685). assertion_content_comment('tOboGo_OtolithMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","an","otolith","are","generated","and","organized","."),4005898). assertion_content_comment('tOboGo_OuterAcrosomalMembrane',s("The","acrosomal","membrane","region","that","underlies","the","plasma","membrane","of","the","sperm",".","This","membrane","fuses","with","the","sperm","plasma","membrane","as","part","of","the","acrosome","reaction","."),3989648). assertion_content_comment('tOboGo_OuterDenseFiber',s("Structure","or","material","found","in","the","flagella","of","mammalian","sperm","that","surrounds","each","of","the","nine","microtubule","doublets",",","giving","a","9","+","9","+","2","arrangement","rather","than","the","9","+","2","pattern","usually","seen",".","These","dense","fibers","are","stiff","and","noncontractile","."),4361470). assertion_content_comment('tOboGo_OuterEarEmergence',s("The","growth","of","the","outer","ear","."),4108578). assertion_content_comment('tOboGo_OuterEarMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","outer","ear","are","generated","and","organized",".","The","outer","ear","is","the","part","of","the","ear","external","to","the","tympanum","(","eardrum",")","It","consists","of","a","tube","(","the","external","auditory","meatus",")","that","directs","sound","waves","on","to","the","tympanum",",","and","may","also","include","the","external","pinna",",","which","extends","beyond","the","skull","."),4078726). assertion_content_comment('tOboGo_OuterEarUnfolding',s("The","opening","and","spreading","out","of","the","outer","ear","."),4108591). assertion_content_comment('tOboGo_OuterEndosporeMembrane',s("The","outer","membrane","around","a","bacterial","endospore",",","located","between","the","endospore","cortex","and","endospore","coat","."),4094762). assertion_content_comment('tOboGo_OuterMedullaryCollectingDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","outer","medullary","collecting","duct","over","time",",","from","its","formation","to","the","mature","structure",".","The","outer","medullary","collecting","duct","is","the","portion","of","the","collecting","duct","that","lies","in","the","renal","outer","medulla","."),4158080). assertion_content_comment('tOboGo_OuterMembraneExporterPorin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4292362). assertion_content_comment('tOboGo_OuterMembrane',s("The","external","membrane","of","Gram-negative","bacteria","or","certain","organelles","such","as","mitochondria","and","chloroplasts",";","freely","permeable","to","most","ions","and","metabolites","."),3980239). assertion_content_comment('tOboGo_OuterMitochondrialMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","mitochondrial","outer","membrane","."),4133089). assertion_content_comment('tOboGo_OuterMucusLayer',s("The","outer","of","two","mucus","layers","secreted","by","epithelial","cells","in","the","colon",";","the","outer","mucus","layer","is","loosely","packed","and","can","be","colonized","by","bacteria","."),4176527). assertion_content_comment('tOboGo_OuterPlaqueOfSpindlePoleBody',s("One","of","three","laminate","structures","that","form","the","spindle","pole","body",";","the","outer","plaque","is","in","the","cytoplasm","."),4007225). assertion_content_comment('tOboGo_OuterStripeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","outer","stripe","over","time",",","from","its","formation","to","the","mature","structure",".","The","outer","stripe","is","the","region","of","the","kidney","outer","medulla","that","lies","just","below","the","cortex",".","The","proximal","straight","tubules","(","S3",")","characterize","this","region","."),4123699). assertion_content_comment('tOboGo_OutflowTractMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","outflow","tract","are","generated","and","organized",".","The","outflow","tract","is","the","portion","of","the","heart","through","which","blood","flows","into","the","arteries","."),4001413). assertion_content_comment('tOboGo_OutflowTractSeptumMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","outflow","tract","septum","are","generated","and","organized",".","The","outflow","tract","septum","is","a","partition","in","the","outflow","tract","."),4003641). assertion_content_comment('tOboGo_OutwardMigrationOfDeepNuclearNeurons',s("The","directed","movement","of","a","deep","nuclear","neuron","from","their","ventrolateral","origin","to","a","rostrodorsal","region","of","the","cerebellar","plate","."),4048006). assertion_content_comment('tOboGo_OutwardRectifierPotassiumChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","potassium","ion","by","an","outwardly-rectifying","voltage-gated","channel",".","An","outwardly","rectifying","current-voltage","relation","is","one","where","at","any","given","driving","force","the","outward","flow","of","K","+","ions","exceeds","the","inward","flow","for","the","opposite","driving","force","."),4217907). assertion_content_comment('tOboGo_OvarianCumulusExpansion',s("Increase","in","size","of","the","cumulus","surrounding","the","oocyte","including","change","in","morphology","due","to","proliferation","and","dispersion","of","cumulus","cells","."),3981257). assertion_content_comment('tOboGo_OvarianFollicleAtresia',s("Ovarian","follicle","demise","mediated","by","apoptosis","."),3981322). assertion_content_comment('tOboGo_OvarianFollicleCellDevelopment',s("The","process","that","occurs","during","oogenesis","involving","the","ovarian","follicle","cells",",","somatic","cells","which","surround","the","germ","cells","of","an","ovary",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4014779). assertion_content_comment('tOboGo_OvarianFollicleCellMigration',s("The","directed","movement","of","an","ovarian","follicle","cell","that","takes","place","during","oogenesis",".","During","egg","chamber","formation",",","follicle","cells","migrate","to","envelop","the","germ-line","cysts","and","move","in","between","cysts",".","At","stage","10B",",","follicle","cells","migrate","centripetally","between","the","nurse","cells","and","the","oocyte",",","enclosing","the","anterior","of","the","egg",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4018790). assertion_content_comment('tOboGo_OvarianFollicleCellStalkFormation',s("Development","of","ovarian","follicle","cells","to","create","the","interfollicular","stalks","that","connect","the","egg","chambers","of","progressive","developmental","stages",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4052161). assertion_content_comment('tOboGo_OvarianFollicleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","ovarian","follicle","over","time",",","from","its","formation","to","the","mature","structure","."),3981202). assertion_content_comment('tOboGo_OvarianFollicleEndowment',s("Association","of","oocytes","with","supporting","epithelial","granulosa","cells","to","form","primordial","follicles","."),3981213). assertion_content_comment('tOboGo_OvarianFollicleRupture',s("Disruption","of","theca","cell","layer","releasing","follicular","fluid","and/or","the","oocyte","."),3981846). assertion_content_comment('tOboGo_OvarianFusomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","fusome","of","ovarian","cells",",","an","organelle","derived","from","the","spectrosome",".","It","anchors","the","mitotic","spindle","pole","to","provide","orientation","during","cystoblast","cell","divisions","."),4052006). assertion_content_comment('tOboGo_OvarianNurseCellToOocyteTransport',s("Transfer","of","constituents","synthesized","in","the","ovarian","nurse","cells","to","the","oocyte",",","through","the","ring","canals",",","as","the","egg","chamber","is","growing",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4018653). assertion_content_comment('tOboGo_OvarySeptumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","ovary","septum","over","time",",","from","its","formation","to","the","mature","structure",".","The","ovary","septum","is","the","thin","partition","that","divides","the","ovary",",","the","basal","portion","of","a","carpel","or","group","of","fused","carpels",",","that","encloses","the","ovule","(","s",")"),4147505). assertion_content_comment('tOboGo_Oviposition',s("The","deposition","of","eggs","(","either","fertilized","or","not",")","upon","a","surface","or","into","a","medium","such","as","water","."),4099030). assertion_content_comment('tOboGo_OvulationCycleProcess',s("A","process","involved","in","the","sexual","cycle","seen","in","females",",","often","with","physiologic","changes","in","the","endometrium","that","recur","at","regular","intervals","during","the","reproductive","years","."),3981142). assertion_content_comment('tOboGo_OvulationCycle',s("The","type","of","sexual","cycle","seen","in","females",",","often","with","physiologic","changes","in","the","endometrium","that","recur","at","regular","intervals","during","the","reproductive","years","."),3981138). assertion_content_comment('tOboGo_OvulationFromOvarianFollicle',s("The","process","leading","to","the","rupture","of","the","follicle",",","releasing","the","centrally","located","oocyte","into","the","oviduct",".","An","example","of","this","is","found","in","Mus","musculus","."),3981826). assertion_content_comment('tOboGo_Ovulation',s("The","release","of","a","mature","ovum/oocyte","from","an","ovary","."),3981823). assertion_content_comment('tOboGo_OvuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","ovule","over","time",",","from","its","formation","to","the","mature","structure",".","The","ovule","is","the","structure","in","seed","plants","enclosing","the","female","gametophyte",",","and","is","composed","of","the","nucellus",",","one","or","two","integuments",",","and","the","funiculus",";","it","develops","into","the","seed","."),4028915). assertion_content_comment('tOboGo_OvuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","ovule","are","generated","and","organized",".","The","ovule","is","the","structure","in","seed","plants","enclosing","the","female","gametophyte",",","and","is","composed","of","the","nucellus",",","one","or","two","integuments",",","and","the","funiculus",";","it","develops","into","the","seed","."),4028917). assertion_content_comment('tOboGo_OxalateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","oxalate",",","the","organic","acid","ethanedioate","."),4341680). assertion_content_comment('tOboGo_OxalateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","oxalate",",","the","organic","acid","ethanedioate","."),4341664). assertion_content_comment('tOboGo_OxalateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","oxalate","=","CO","(","2",")","+","formate","."),4358786). assertion_content_comment('tOboGo_OxalateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","oxalate",",","the","organic","acid","ethanedioate","."),4341628). assertion_content_comment('tOboGo_OxalateOxidaseActivity',s("Catalysis","of","the","reaction",":","2","H","(","+",")","+","O","(","2",")","+","oxalate","=","2","CO","(","2",")","+","H","(","2",")","O","(","2",")"),4271219). assertion_content_comment('tOboGo_OxalateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","oxalate","from","one","side","of","the","membrane","to","the","other",".","Oxalate",",","or","ethanedioic","acid",",","occurs","in","many","plants","and","is","highly","toxic","to","animals","."),4242067). assertion_content_comment('tOboGo_OxalateTransport',s("The","directed","movement","of","oxalate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Oxalate",",","or","ethanedioic","acid",",","occurs","in","many","plants","and","is","highly","toxic","to","animals","."),4242079). assertion_content_comment('tOboGo_OxalicAcidSecretion',s("The","controlled","release","of","oxalic","acid",",","ethanedioic","acid",",","by","a","cell","or","group","of","cells","."),4357029). assertion_content_comment('tOboGo_OxaloacetaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","oxaloacetate","=","acetate","+","H","(","+",")","+","oxalate","."),4308370). assertion_content_comment('tOboGo_OxaloacetateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","oxaloacetate","=","pyruvate","+","CO2","."),4247519). assertion_content_comment('tOboGo_OxaloacetateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","oxaloacetate",",","the","anion","of","oxobutanedioic","acid",",","an","important","intermediate","in","metabolism",",","especially","as","a","component","of","the","TCA","cycle","."),4224415). assertion_content_comment('tOboGo_OxaloacetateSecondaryActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","oxaloacetate","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4346183). assertion_content_comment('tOboGo_OxaloacetateTautomeraseActivity',s("Catalysis","of","the","reaction",":","oxaloacetate","=","&","lt",";","stereo","&","gt",";","enol","&","lt",";","/stereo","&","gt",";","-oxaloacetate","."),4271231). assertion_content_comment('tOboGo_OxaloacetateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","oxaloacetate",",","the","anion","of","oxobutanedioic","acid",",","from","one","side","of","the","membrane","to","the","other","."),4297316). assertion_content_comment('tOboGo_OxaloacetateTransport',s("The","directed","movement","of","oxaloacetate",",","the","anion","of","oxobutanedioic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290834). assertion_content_comment('tOboGo_OxaloglycolateReductaseDecarboxylatingActivity',s("Catalysis","of","the","reaction",":","glycerate","+","CO2","+","NAD","(","P",")","+","=","NAD","(","P",")","H","+","H","+","+","2-hydroxy-3-oxosuccinate","."),4364267). assertion_content_comment('tOboGo_OxalomalateLyaseActivity',s("Catalysis","of","the","reaction",":","3-oxalomalate","=","glyoxylate","+","oxaloacetate","."),4264440). assertion_content_comment('tOboGo_OxamateCarbamoyltransferaseActivity',s("Catalysis","of","the","reaction",":","carbamoyl","phosphate","+","oxamate","=","oxalurate","+","phosphate","."),4264451). assertion_content_comment('tOboGo_OxazoleOrThiazoleBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","oxazole","or","thiazole",",","five-membered","heterocyclic","ring","structures","containing","an","oxygen","and","a","sulfur",",","respectively",",","in","the","1-position","and","a","nitrogen","in","the","3-position","."),4284678). assertion_content_comment('tOboGo_OxazoleOrThiazoleMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","oxazole","or","thiazole",",","five-membered","heterocyclic","ring","structures","containing","an","oxygen","and","a","sulfur",",","respectively",",","in","the","1-position","and","a","nitrogen","in","the","3-position","."),4284675). assertion_content_comment('tOboGo_OxidativeDeethylation',s("The","process","of","removing","one","or","more","ethyl","groups","from","a","molecule",",","involving","the","oxidation","(","i.e",".","electron","loss",")","of","one","or","more","atoms","in","the","substrate","."),4172676). assertion_content_comment('tOboGo_OxidativeDemethylation',s("The","process","of","removing","one","or","more","methyl","groups","from","a","molecule",",","involving","the","oxidation","(","i.e",".","electron","loss",")","of","one","or","more","atoms","in","the","substrate","."),4177581). assertion_content_comment('tOboGo_OxidativeDNADemethylaseActivity',s("Catalysis","of","the","removal","of","the","methyl","group","from","one","or","more","nucleotides","within","a","DNA","molecule","involving","the","oxidation","(","i.e",".","electron","loss",")","of","one","or","more","atoms","."),4378957). assertion_content_comment('tOboGo_OxidativeDNADemethylation',s("Removal","of","the","methyl","group","from","one","or","more","nucleotides","within","a","DNA","molecule","involving","the","oxidation","(","i.e",".","electron","loss",")","of","one","or","more","atoms","."),4378585). assertion_content_comment('tOboGo_OxidativePhosphorylation',s("The","phosphorylation","of","ADP","to","ATP","that","accompanies","the","oxidation","of","a","metabolite","through","the","operation","of","the","respiratory","chain",".","Oxidation","of","compounds","establishes","a","proton","gradient","across","the","membrane",",","providing","the","energy","for","ATP","synthesis","."),3989679). assertion_content_comment('tOboGo_OxidativePhosphorylationUncouplerActivity',s("Catalysis","of","the","transfer","of","protons","from","mitochondrial","intermembrane","space","into","mitochondrial","matrix",",","dissipating","the","proton","gradient","across","the","mitochondrial","inner","membrane","established","by","the","electron","transport","chain","during","the","oxidative","phosphorylation","(","proton","leak",")","Proton","leak","uncouples","the","processes","of","electron","transport/proton","generation","and","ATP","synthesis","."),4269403). assertion_content_comment('tOboGo_OxidativePhotosyntheticCarbonPathway',s("The","reactions","of","the","C2","pathway","bring","about","the","metabolic","conversion","of","two","molecules","of","2-phosphoglycolate","to","one","molecule","of","3-phosphoglycerate",",","which","can","be","used","by","the","C3","cycle",",","and","one","molecule","of","carbon","dioxide","(","CO2",")"),4022150). assertion_content_comment('tOboGo_OxidativeRNADemethylaseActivity',s("Catalysis","of","the","removal","of","a","methyl","group","from","one","or","more","nucleosides","within","a","RNA","molecule","involving","the","oxidation","(","i.e",".","electron","loss",")","of","one","or","more","atoms","."),4378968). assertion_content_comment('tOboGo_OxidativeRNADemethylation',s("The","removal","of","the","methyl","group","from","one","or","more","nucleotides","within","an","RNA","molecule","involving","oxidation","(","i.e",".","electron","loss",")","of","one","or","more","atoms","."),4378565). assertion_content_comment('tOboGo_OxidizedDNABinding',s("Interacting","selectively","and","non-covalently","with","oxidized","residues","in","DNA","."),4333702). assertion_content_comment('tOboGo_OxidizedGlutathioneReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228178). assertion_content_comment('tOboGo_OxidizedPurineDNABinding',s("Interacting","selectively","and","non-covalently","with","oxidized","purine","residues","in","DNA","."),4333727). assertion_content_comment('tOboGo_OxidizedPyrimidineDNABinding',s("Interacting","selectively","and","non-covalently","with","oxidized","pyrimidine","residues","in","DNA","."),4333705). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnAHemeGroupOfDonorsNitrogenousGroupAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","heme","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","nitrogenous","group","."),4271541). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnAHemeGroupOfDonorsOxygenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","heme","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","oxygen","."),4211586). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnAHemeGroupOfDonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","heme","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4211582). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnASulfurGroupOfDonorsCytochromeAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","sulfur-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","cytochrome","."),4173898). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnASulfurGroupOfDonorsDisulfideAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","sulfur-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","disulfide","."),4157837). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnASulfurGroupOfDonorsNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","sulfur-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","or","NADP","."),4202008). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnASulfurGroupOfDonorsOxygenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","sulfur-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","oxygen","."),4254395). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnASulfurGroupOfDonorsQuinoneOrSimilarCompoundAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","sulfur-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","quinone","or","a","related","compound","."),4173875). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnASulfurGroupOfDonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","sulfur-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4157833). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnCH2GroupsOtherAcceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","disulfide",",","NAD",",","NADP","or","oxygen","."),4301352). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnCHOrCH2GroupsDisulfideAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","disulfide","group","."),4201353). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnCHOrCH2GroupsNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","+","or","NADP","."),4177426). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnCHOrCH2GroupsOxygenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","oxygen","molecule","."),4177389). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnCHOrCH2GroupsQuinoneOrSimilarCompoundAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","quinone","or","similar","acceptor","molecule","."),4341758). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnCHOrCH2Groups',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4177386). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnDiphenolsAndRelatedSubstancesAsDonorsCytochromeAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","diphenol",",","or","related","compound",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","cytochrome","."),4246724). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnDiphenolsAndRelatedSubstancesAsDonorsNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","diphenol",",","or","related","compound",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","or","NADP","."),4306079). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnDiphenolsAndRelatedSubstancesAsDonorsOtherAcceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","diphenol",",","or","related","compound",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","a","cytochrome",",","NAD",",","NADP","or","oxygen","."),4306090). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnDiphenolsAndRelatedSubstancesAsDonorsOxygenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","diphenol",",","or","related","compound",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","oxygen","."),4212158). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnDiphenolsAndRelatedSubstancesAsDonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","diphenol","or","related","substance","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4212155). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHalogenInDonors',s("Catalysis","of","an","oxidation-reduction","in","which","a","halogen","in","the","donor","substance","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4186460). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHalogenInDonorsWithNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","in","which","a","halogen","in","the","donor","substance","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","or","NADP","."),4186462). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHemeGroupOfDonorsOtherAcceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","heme","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","a","nitrogenous","group","or","oxygen","."),4305629). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHydrogenAsDonorCytochromeAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","acts","as","an","electron","donor","and","reduces","a","cytochrome","."),4305977). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHydrogenAsDonorNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","acts","as","an","electron","donor","and","reduces","NAD","or","NADP","."),4267858). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHydrogenAsDonorOtherAcceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","is","the","electron","donor","and","reduces","an","acceptor","other","than","a","cytochrome",",","an","iron-sulfur","protein",",","NAD",",","NADP","or","a","quinone","or","similar","compound","."),4301225). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHydrogenAsDonor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","acts","as","an","electron","donor","."),4183202). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHydrogenAsDonorWithAQuinoneOrSimilarCompoundAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","acts","as","an","electron","donor","and","reduces","quinone","or","similar","compound","."),4361695). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnHydrogenAsDonorWithOtherKnownAcceptors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","reduces","a","known","acceptor","other","than","a","cytochrome",",","an","iron-sulfur","protein",",","NAD",",","NADP",",","or","a","quinone","or","similar","compound","."),4183205). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnNADHOrNADPHFlavinAsAcceptor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4305724). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnNADHOrNADPHHemeProteinAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","NADH","or","NADPH","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","heme","protein","."),4185230). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnNADHOrNADPHNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","NADH","or","NADPH","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","+","or","NADP","."),4185338). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnNADHOrNADPHNitrogenousGroupAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","NADH","or","NADPH","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","nitrogenous","group","."),4182977). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnNADHOrNADPHOtherAcceptor',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","NADH","or","NADPH","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","disulfide",",","a","heme","protein",",","NAD",",","NADP",",","a","nitrogenous","group",",","a","quinone","or","similar","compound","or","oxygen","."),4305735). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnNADHOrNADPHOxygenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","NADH","or","NADPH","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","oxygen","molecule","."),4277493). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnNADHOrNADPHQuinoneOrSimilarCompoundAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","NADH","or","NADPH","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","quinone","or","a","similar","acceptor","molecule","."),4184586). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnNADHOrNADPH',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","NADH","or","NADPH","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4182973). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnOtherNitrogenousCompoundsAsDonorsCytochromeAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","nitrogenous","group",",","excluding","NH","and","NH2","groups",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","cytochrome","."),4266891). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnOtherNitrogenousCompoundsAsDonorsOtherAcceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","nitrogenous","group",",","excluding","NH","and","NH2","groups",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","a","cytochrome",",","an","iron-sulfur","protein",",","oxygen",",","NAD","or","NADP","."),4305652). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnOtherNitrogenousCompoundsAsDonorsOxygenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","nitrogenous","group",",","excluding","NH","and","NH2","groups",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","oxygen","."),4192082). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnOtherNitrogenousCompoundsAsDonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","nitrogenous","group",",","excluding","NH","and","NH2","groups",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4186402). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnOtherNitrogenousCompoundsAsDonorsWithAQuinoneOrSimilarCompoundAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","nitrogenous","group",",","excluding","NH","and","NH2","groups",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","quinone","or","similar","compound","."),4186405). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnOtherNitrogenousCompoundsAsDonorsWithNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","nitrogenous","group",",","excluding","NH","and","NH2","groups",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","or","NADP","."),4247593). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnOtherSubstrates',s("OBSOLETE",".","A","grouping","term","for","oxidoreductase","that","cannot","be","more","accurately","categorized","."),4301247). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenAnotherCompoundAsOneDonorAndIncorporationOfOneAtomOfOxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","each","of","two","donors",",","and","one","atom","of","oxygen","is","incorporated","into","one","donor","."),4205368). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenMiscellaneous',s("OBSOLETE",".","A","grouping","term","for","oxidoreductases",",","acting","on","paired","donors","with","incorporation","or","reduction","of","molecular","oxygen",",","that","cannot","be","more","accurately","categorized","."),4301325). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenNADHOrNADPHAsOneDonorAndIncorporationOfOneAtomOfOxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","NADH","or","NADPH","and","one","other","donor",",","and","one","atom","of","oxygen","is","incorporated","into","one","donor","."),4073689). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenNADHOrNADPHAsOneDonorAndIncorporationOfTwoAtomsOfOxygenIntoOneDonor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","NADH","or","NADPH","and","one","other","donor",",","and","two","atoms","of","oxygen","is","incorporated","into","one","donor","."),4247478). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenReducedAscorbateAsOneDonorAndIncorporationOfOneAtomOfOxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","reduced","ascorbate","and","one","other","donor",",","and","one","atom","of","oxygen","is","incorporated","into","one","donor","."),4205333). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenReducedFlavinOrFlavoproteinAsOneDonorAndIncorporationOfOneAtomOfOxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","reduced","flavin","or","flavoprotein","and","one","other","donor",",","and","one","atom","of","oxygen","is","incorporated","into","one","donor","."),4173222). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenReducedPteridineAsOneDonorAndIncorporationOfOneAtomOfOxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","reduced","pteridine","and","one","other","donor",",","and","one","atom","of","oxygen","is","incorporated","into","one","donor","."),4205129). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","each","of","two","donors",",","and","molecular","oxygen","is","reduced","or","incorporated","into","a","donor","."),4073686). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenWithNADHOrNADPHAsOneDonorAndTheOtherDehydrogenated',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","NADH","or","NADPH","and","one","other","donor",",","and","the","latter","donor","is","dehydrogenated","."),4270201). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPairedDonorsWithOxidationOfAPairOfDonorsResultingInTheReductionOfMolecularOxygenToTwoMoleculesOfWater',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","each","of","two","donors",",","and","molecular","oxygen","is","reduced","to","two","molecules","of","water","."),4201581). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPeroxideAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","the","peroxide","group","acts","as","a","hydrogen","or","electron","acceptor","."),4203692). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPhosphorusOrArsenicInDonorsDisulfideAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","phosphorus-","or","arsenic-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","disulfide","."),4248925). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPhosphorusOrArsenicInDonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","phosphorus-","or","arsenic-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4248922). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPhosphorusOrArsenicInDonorsWithNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","phosphorus-","or","arsenic-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","NAD","(","P",")","+","to","NAD","(","P",")","H","."),4265955). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPhosphorusOrArsenicInDonorsWithOtherAcceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","phosphorus","or","arsenic","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","disulfide",",","NAD","or","NADP","."),4269364). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnPhosphorusOrArsenicInDonorsWithOtherKnownAcceptors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","phosphorus","or","arsenic","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","known","acceptor","other","than","disulfide",",","NAD","or","NADP","."),4269322). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnReducedFlavodoxinAsDonorDinitrogenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","reduced","flavodoxin","acts","as","a","hydrogen","or","electron","donor","and","reduces","dinitrogen","."),4271493). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnReducedFlavodoxinAsDonor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","reduced","flavodoxin","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4271491). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnSingleDonorsWithIncorporationOfMolecularOxygenIncorporationOfOneAtomOfOxygenInternalMonooxygenasesOrInternalMixedFunctionOxidases',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","one","donor",",","and","one","oxygen","atom","is","incorporated","into","a","donor","."),4190942). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnSingleDonorsWithIncorporationOfMolecularOxygenIncorporationOfTwoAtomsOfOxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","one","donor",",","and","two","oxygen","atoms","is","incorporated","into","a","donor","."),4188296). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnSingleDonorsWithIncorporationOfMolecularOxygenMiscellaneous',s("OBSOLETE",".","A","grouping","term","for","oxidoreductases","acting","on","single","donors","with","incorporation","of","molecular","oxygen","that","cannot","be","more","accurated","categorized","."),4301236). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnSingleDonorsWithIncorporationOfMolecularOxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","one","donor",",","and","molecular","oxygen","is","incorporated","into","a","donor","."),4188291). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnSulfurGroupOfDonorsOtherAcceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","sulfur-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","quinone","or","a","related","compound",",","oxygen",",","NAD",",","NADP",",","an","iron-sulfur","protein",",","disulfide","or","a","cytochrome","."),4305617). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnSuperoxideRadicalsAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","superoxide","radical","(","O2-","or","O2.-",")","acts","as","a","hydrogen","or","electron","acceptor","."),4201915). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnTheAldehydeOrOxoGroupOfDonorsCytochromeAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","aldehyde","or","ketone","(","oxo",")","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","cytochrome","."),4248099). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnTheAldehydeOrOxoGroupOfDonorsDisulfideAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","aldehyde","or","ketone","(","oxo",")","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","disulfide","."),4189311). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnTheAldehydeOrOxoGroupOfDonorsNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","aldehyde","or","ketone","(","oxo",")","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","or","NADP","."),4182069). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnTheAldehydeOrOxoGroupOfDonorsOtherAcceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","aldehyde","or","ketone","(","oxo",")","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","NAD",",","NADP",",","oxygen",",","an","iron-sulfur","protein",",","disulphide","or","a","cytochrome","."),4305835). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnTheAldehydeOrOxoGroupOfDonorsOxygenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","aldehyde","or","ketone","(","oxo",")","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","oxygen","."),4200742). assertion_content_comment('tOboGo_OxidoreductaseActivityActingOnTheAldehydeOrOxoGroupOfDonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","aldehyde","or","ketone","(","oxo",")","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4182066). assertion_content_comment('tOboGo_OxidoreductaseActivityOxidizingMetalIonsNADOrNADPAsAcceptor',s("Catalysis","of","an","oxidation-reduction","in","which","the","oxidation","state","of","metal","ion","is","altered","and","NAD","+","or","NADP","+","acts","as","an","electron","acceptor","."),4230030). assertion_content_comment('tOboGo_OxidoreductaseActivityOxidizingMetalIonsOxygenAsAcceptor',s("Catalysis","of","an","oxidation-reduction","in","which","the","oxidation","state","of","metal","ion","is","altered","and","oxygen","acts","as","an","electron","acceptor","."),4208567). assertion_content_comment('tOboGo_OxidoreductaseActivityOxidizingMetalIons',s("Catalysis","of","an","oxidation-reduction","in","which","the","oxidation","state","of","metal","ion","is","altered","."),4208565). assertion_content_comment('tOboGo_OxidoreductaseActivityOxidizingMetalIonsWithFlavinAsAcceptor',s("Catalysis","of","an","oxidation-reduction","in","which","the","oxidation","state","of","metal","ion","is","altered","and","flavin","acts","as","an","electron","acceptor","."),4327865). assertion_content_comment('tOboGo_OxidoreductaseActivity',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction",",","a","reversible","chemical","reaction","in","which","the","oxidation","state","of","an","atom","or","atoms","within","a","molecule","is","altered",".","One","substrate","acts","as","a","hydrogen","or","electron","donor","and","becomes","oxidized",",","while","the","other","acts","as","hydrogen","or","electron","acceptor","and","becomes","reduced","."),4073669). assertion_content_comment('tOboGo_OxidoreductionCoenzymeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","coenzymes","that","are","required",",","in","addition","to","an","enzyme","and","a","substrate",",","for","an","oxidoreductase","reaction","to","proceed","."),4021140). assertion_content_comment('tOboGo_OxidosqualeneCyclaseActivity',s("Catalysis","of","the","cyclization","of","(","S",")","-2",",","3-epoxysqualene","to","form","a","triterpene","."),4182151). assertion_content_comment('tOboGo_OximinotransaminaseActivity',s("Catalysis","of","the","reversible","transfer","of","an","oxime","group","to","an","acceptor","."),4264469). assertion_content_comment('tOboGo_OximinotransferaseActivity',s("Catalysis","of","the","reaction",":","2-","(","hydroxyimino",")","propanoate","+","acetone","=","acetone","oxime","+","pyruvate","."),4264471). assertion_content_comment('tOboGo_OxoacidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","oxoacid",";","an","oxoacid","is","a","compound","which","contains","oxygen",",","at","least","one","other","element",",","and","at","least","one","hydrogen","bound","to","oxygen",",","and","which","produces","a","conjugate","base","by","loss","of","positive","hydrogen","ion","(","s",")","(","hydrons",")"),3978973). assertion_content_comment('tOboGo_OxoglutarateDehydrogenaseComplex',s("A","complex","of","multiple","copies","of","three","enzymatic","components",":","oxoglutarate","dehydrogenase","(","lipoamide",")",";","EC",":","1.2.4.2","(","E1",")",",","dihydrolipoamide","S-succinyltransferase",";","EC",":","2.3.1.61","(","E2",")","and","dihydrolipoamide","dehydrogenase",";","EC",":","1.8.1.4","(","E3",")",";","catalyzes","the","overall","conversion","of","2-oxoglutarate","to","succinyl-CoA","and","carbon","dioxide","(","CO2",")"),4023774). assertion_content_comment('tOboGo_OxoglutarateDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","CoA","+","NAD","+","=","succinyl-CoA","+","CO2","+","NADH","."),4353928). assertion_content_comment('tOboGo_OxoglutarateDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","CoA","+","NADP","(","+",")","=","CO","(","2",")","+","NADPH","+","succinyl-CoA","."),4271243). assertion_content_comment('tOboGo_Oxoglutarate_MalateAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","oxoglutarate","(","out",")","+","malate","(","in",")","=","oxoglutarate","(","in",")","+","malate","(","out",")"),4228486). assertion_content_comment('tOboGo_OxygenAndReactiveOxygenSpeciesMetabolicProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","involving","dioxygen","(","O2",")",",","or","any","of","the","reactive","oxygen","species",",","e.g",".","superoxide","anions","(","O2-",")",",","hydrogen","peroxide","(","H2O2",")",",","and","hydroxyl","radicals","(","-OH",")"),4228823). assertion_content_comment('tOboGo_OxygenBinding',s("Interacting","selectively","and","non-covalently","with","oxygen","(","O2",")"),4233300). assertion_content_comment('tOboGo_OxygenEvolvingActivity',s("Catalysis","of","the","reaction",":","2","H2O","=","O2","+","4","H","+","+","4","e-",".","The","evolution","of","oxygen","from","oxidizing","water","is","carried","out","by","the","oxygen","evolving","complex","in","photosystem","II","of","plants",".","P680","+",",","the","photochemically","oxidized","reaction-center","chlorophyll","of","PSII",",","is","a","strong","biological","oxidant",".","The","reduction","potential","of","P680","+","is","more","positive","than","that","of","water",",","and","thus","it","can","oxidize","water","to","give","O2","and","H","+","ions",".","The","oxygen","escapes","as","a","gas","while","the","H","+","ions","remain","in","solution","inside","the","thylakoid","vesicle","."),4262859). assertion_content_comment('tOboGo_OxygenEvolvingComplex',s("A","complex",",","composed","of","a","cluster","of","manganese",",","calcium","and","chloride","ions","bound","to","extrinsic","proteins",",","that","catalyzes","the","splitting","of","water","to","O2","and","4","H","+","In","cyanobacteria","there","are","five","extrinsic","proteins","in","OEC","(","PsbO",",","PsbP-like",",","PsbQ-like",",","PsbU","and","PsbV",")",",","while","in","plants","there","are","only","three","(","PsbO",",","PsbP","and","PsbQ",")"),4022687). assertion_content_comment('tOboGo_OxygenHomeostasis',s("A","homeostatic","process","involved","in","the","maintenance","of","an","internal","steady","state","of","oxygen","within","an","organism","or","cell","."),4333674). assertion_content_comment('tOboGo_OxygenMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","diatomic","oxygen","(","O2",")"),4143001). assertion_content_comment('tOboGo_OxygenSensorActivity',s("Interacting","selectively","and","non-covalently","with","and","responding",",","e.g",".","by","conformational","change",",","to","changes","in","the","cellular","level","of","oxygen","(","O2",")"),4233304). assertion_content_comment('tOboGo_OxygenTransporterActivity',s("Enables","the","directed","movement","of","oxygen","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4216326). assertion_content_comment('tOboGo_OxygenTransport',s("The","directed","movement","of","oxygen","(","O2",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4289928). assertion_content_comment('tOboGo_OxylipinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","oxylipin",",","any","of","a","group","of","biologically","active","compounds","formed","by","oxidative","metabolism","of","polyunsaturated","fatty","acids","."),4147800). assertion_content_comment('tOboGo_OxylipinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","oxylipin",",","any","of","a","group","of","biologically","active","compounds","formed","by","oxidative","metabolism","of","polyunsaturated","fatty","acids","."),4147785). assertion_content_comment('tOboGo_OxysterolBinding',s("Interacting","selectively","and","non-covalently","with","oxysterol",",","an","oxidized","form","of","cholesterol","."),4245787). assertion_content_comment('tOboGo_OxytocinReceptorActivity',s("Combining","with","oxytocin","to","initiate","a","change","in","cell","activity","."),4198959). assertion_content_comment('tOboGo_OxytocinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","oxytocin","receptor","."),4324103). assertion_content_comment('tOboGo_P1Peroxisome',s("A","subform","of","peroxisome","that","corresponds","to","an","intermediate","in","a","peroxisome","assembly","pathway",",","which","operates","by","conversion","of","peroxisomal","subforms","in","the","direction","P1",",","P2","-","&","gt",";","P3","-","&","gt",";","P4","-","&","gt",";","P5","-","&","gt",";","P6",".","P1","peroxisomes","are","distinguished","from","the","other","subforms","on","the","bases","of","buoyant","density","and","protein","content",";","they","contain","fewer","peroxisomal","proteins","than","the","other","subforms","."),4233215). assertion_content_comment('tOboGo_P2Peroxisome',s("A","subform","of","peroxisome","that","corresponds","to","an","intermediate","in","a","peroxisome","assembly","pathway",",","which","operates","by","conversion","of","peroxisomal","subforms","in","the","direction","P1",",","P2","-","&","gt",";","P3","-","&","gt",";","P4","-","&","gt",";","P5","-","&","gt",";","P6",".","P2","peroxisomes","are","distinguished","from","the","other","subforms","on","the","bases","of","buoyant","density","and","protein","content",";","they","are","the","least","dense","of","the","subforms","observed","."),4233226). assertion_content_comment('tOboGo_P2Y10NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y10","nucleotide","receptor","."),4324531). assertion_content_comment('tOboGo_P2Y11NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y11","nucleotide","receptor","."),4324241). assertion_content_comment('tOboGo_P2Y1NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y1","nucleotide","receptor","."),4324571). assertion_content_comment('tOboGo_P2Y2NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y2","nucleotide","receptor","."),4324561). assertion_content_comment('tOboGo_P2Y4NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y4","nucleotide","receptor","."),4324591). assertion_content_comment('tOboGo_P2Y5NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y5","nucleotide","receptor","."),4324581). assertion_content_comment('tOboGo_P2Y6NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y6","nucleotide","receptor","."),4324521). assertion_content_comment('tOboGo_P2Y8NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y8","nucleotide","receptor","."),4324511). assertion_content_comment('tOboGo_P2Y9NucleotideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","P2Y9","nucleotide","receptor","."),4324541). assertion_content_comment('tOboGo_P3Peroxisome',s("A","subform","of","peroxisome","that","corresponds","to","an","intermediate","in","a","peroxisome","assembly","pathway",",","which","operates","by","conversion","of","peroxisomal","subforms","in","the","direction","P1",",","P2","-","&","gt",";","P3","-","&","gt",";","P4","-","&","gt",";","P5","-","&","gt",";","P6",".","P3","peroxisomes","are","formed","by","fusion","of","P1","and","P2","peroxisomes",",","and","are","distinguished","from","the","other","subforms","on","the","bases","of","buoyant","density","and","protein","content","."),4233270). assertion_content_comment('tOboGo_P4Peroxisome',s("A","subform","of","peroxisome","that","corresponds","to","an","intermediate","in","a","peroxisome","assembly","pathway",",","which","operates","by","conversion","of","peroxisomal","subforms","in","the","direction","P1",",","P2","-","&","gt",";","P3","-","&","gt",";","P4","-","&","gt",";","P5","-","&","gt",";","P6",".","P4","peroxisomes","are","distinguished","from","the","other","subforms","on","the","bases","of","buoyant","density","and","protein","content","."),4233259). assertion_content_comment('tOboGo_P53Binding',s("Interacting","selectively","and","non-covalently","with","one","of","the","p53","family","of","proteins","."),4374217). assertion_content_comment('tOboGo_P5Peroxisome',s("A","subform","of","peroxisome","that","corresponds","to","an","intermediate","in","a","peroxisome","assembly","pathway",",","which","operates","by","conversion","of","peroxisomal","subforms","in","the","direction","P1",",","P2","-","&","gt",";","P3","-","&","gt",";","P4","-","&","gt",";","P5","-","&","gt",";","P6",".","P5","peroxisomes","are","distinguished","from","the","other","subforms","on","the","bases","of","buoyant","density","and","protein","content","."),4233248). assertion_content_comment('tOboGo_P6Peroxisome',s("A","subform","of","peroxisome","that","corresponds","to","an","intermediate","in","a","peroxisome","assembly","pathway",",","which","operates","by","conversion","of","peroxisomal","subforms","in","the","direction","P1",",","P2","-","&","gt",";","P3","-","&","gt",";","P4","-","&","gt",";","P5","-","&","gt",";","P6",".","P6","peroxisomes","are","distinguished","from","the","other","subforms","on","the","bases","of","buoyant","density","and","protein","content",",","and","are","equivalent","to","mature","peroxisomes","."),4233237). assertion_content_comment('tOboGo_PacemakerCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","pacemaker","cell","over","time",",","from","its","formation","to","the","mature","state",".","Pacemaker","cells","are","specialized","cardiomyocytes","that","are","responsible","for","regulating","the","timing","of","heart","contractions","."),4114405). assertion_content_comment('tOboGo_PacemakerCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","pacemaker","cell",".","Pacemaker","cells","are","specialized","cardiomyocytes","that","are","responsible","for","regulating","the","timing","of","heart","contractions","."),4114346). assertion_content_comment('tOboGo_PacemakerCellFateCommitment',s("The","commitment","of","cells","to","pacemaker","cell","fates","and","their","capacity","to","differentiate","into","pacemaker","cells",".","Pacemaker","cells","are","specialized","cardiomyocytes","that","are","responsible","for","regulating","the","timing","of","heart","contractions","."),4114395). assertion_content_comment('tOboGo_Pachytene',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","third","stage","of","prophase","I","in","meiosis",",","in","which","crossing","over","occurs","between","a","chromatid","in","one","partner","and","another","chromatid","in","the","homologous","chromosome","."),3973828). assertion_content_comment('tOboGo_PaclitaxelBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","paclitaxel",",","an","alkaloid","compound","used","as","an","anticancer","treatment","."),4316500). assertion_content_comment('tOboGo_PaclitaxelMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","paclitaxel",",","an","alkaloid","compound","used","as","an","anticancer","treatment","."),4316495). assertion_content_comment('tOboGo_PalateDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","the","palate","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","structure","and","ends","with","the","mature","structure",".","The","palate","is","the","partition","that","separates","the","nasal","and","oral","cavities","."),4109628). assertion_content_comment('tOboGo_PalliumCellProliferationInForebrain',s("The","multiplication","or","reproduction","of","pallium","cells","in","the","forebrain",",","resulting","in","the","expansion","of","the","cell","population","."),4053298). assertion_content_comment('tOboGo_PalliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pallium","over","time",",","from","its","formation","to","the","mature","structure",".","The","pallium","is","the","roof","region","of","the","telencephalon","."),4041129). assertion_content_comment('tOboGo_PalliumGlioblastDivision',s("The","division","of","a","glioblast","in","the","pallium",".","A","glioblast","is","a","dividing","precursor","cell","that","gives","rise","to","glial","cells","."),4053483). assertion_content_comment('tOboGo_PalmitoyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","palmitoyl","(","CH3-","[","CH2","]","14-CO-",")","group","to","an","acceptor","molecule","."),4201522). assertion_content_comment('tOboGo_PalmitoyltransferaseComplex',s("A","protein","complex","with","palmitoyltransferase","activity","."),4062279). assertion_content_comment('tOboGo_PANComplex',s("A","complex","that","possesses","poly","(","A",")","-specific","ribonuclease","activity",";","catalyzes","the","message-specific","shortening","of","mRNA","poly","(","A",")","tails",".","Contains","at","least","two","subunits",",","known","as","Pan2p","and","Pan3p","in","Saccharomyces","."),4320046). assertion_content_comment('tOboGo_PancreasDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pancreas","over","time",",","from","its","formation","to","the","mature","structure",".","The","pancreas","is","an","endoderm","derived","structure","that","produces","precursors","of","digestive","enzymes","and","blood","glucose","regulating","enzymes","."),4001933). assertion_content_comment('tOboGo_PancreasFieldSpecification',s("The","process","in","which","a","specific","region","of","the","gut","is","delineated","into","the","area","in","which","the","pancreas","will","develop","."),4135698). assertion_content_comment('tOboGo_PancreasInduction',s("The","close","range","interaction","of","two","or","more","cells","or","tissues","that","causes","the","cells","of","the","gut","to","change","their","fates","and","specify","the","development","of","the","pancreas","."),4135709). assertion_content_comment('tOboGo_PancreasMorphogenesis',s("Morphogenesis","of","the","pancreas",".","Morphogenesis","is","the","process","in","which","anatomical","structures","are","generated","and","organized","."),4135519). assertion_content_comment('tOboGo_PancreaticACellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","pancreatic","A","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","pancreatic","A","cell","is","a","cell","in","the","pancreas","that","secretes","glucagon","."),4002049). assertion_content_comment('tOboGo_PancreaticACellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and","functional","features","of","a","pancreatic","A","cell",".","A","pancreatic","A","cell","is","a","cell","in","the","pancreas","that","secretes","glucagon","."),4001998). assertion_content_comment('tOboGo_PancreaticACellFateCommitment',s("The","commitment","of","a","cell","to","a","pancreatic","A","cell","and","its","capacity","to","differentiate","into","a","pancreatic","A","cell",".","A","pancreatic","A","cell","is","a","cell","in","the","pancreas","that","secretes","glucagon","."),4006482). assertion_content_comment('tOboGo_PancreaticBudFormation',s("The","morphogenetic","process","in","which","the","foregut","region","specified","to","become","the","pancreas","forms","a","bud","."),4135696). assertion_content_comment('tOboGo_PancreaticDCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","pancreatic","delta","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","delta","cell","is","a","cell","of","the","pancreas","that","produces","somatostatin","."),4006461). assertion_content_comment('tOboGo_PancreaticDCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and","functional","features","that","characterize","a","pancreatic","delta","cell",".","A","delta","cell","is","a","cell","of","the","pancreas","that","produces","somatostatin","."),4002008). assertion_content_comment('tOboGo_PancreaticDCellFateCommitment',s("The","commitment","of","a","cell","to","a","pancreatic","D","cell","fate","and","its","capacity","to","differentiate","into","a","pancreatic","D","cell",".","A","delta","cell","is","a","cell","of","the","pancreas","that","produces","somatostatin","."),4006429). assertion_content_comment('tOboGo_PancreaticECellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","pancreatic","E","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4150363). assertion_content_comment('tOboGo_PancreaticECellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and","functional","features","of","a","pancreatic","E","cell",".","A","pancreatic","E","cell","is","a","cell","in","the","pancreas","that","secretes","ghrelin","."),4150353). assertion_content_comment('tOboGo_PancreaticECellFateCommitment',s("The","commitment","of","a","cell","to","a","pancreatic","E","cell","fate","and","its","capacity","to","differentiate","into","a","pancreatic","E","cell","."),4150373). assertion_content_comment('tOboGo_PancreaticElastaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","proteins",",","including","elastin","."),4246557). assertion_content_comment('tOboGo_PancreaticElastaseIActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","proteins",",","including","elastin",".","Preferential","cleavage",":","Ala-Xaa","."),4246669). assertion_content_comment('tOboGo_PancreaticElastaseIIActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","of","Leu-Xaa",",","Met-Xaa","and","Phe-Xaa",".","Hydrolyzes","elastin","."),4209593). assertion_content_comment('tOboGo_PancreaticJuiceSecretion',s("The","regulated","release","of","pancreatic","juice","by","the","exocrine","pancreas","into","the","upper","part","of","the","intestine",".","Pancreatic","juice","is","slightly","alkaline","and","contains","numerous","enzymes","and","inactive","enzyme","precursors","including","alpha-amylase",",","chymotrypsinogen",",","lipase",",","procarboxypeptidase",",","proelastase",",","prophospholipase","A2",",","ribonuclease",",","and","trypsinogen",".","Its","high","concentration","of","bicarbonate","ions","helps","to","neutralize","the","acid","from","the","stomach","."),4149411). assertion_content_comment('tOboGo_PancreaticPolypeptideReceptorActivity',s("Combining","with","pancreatic","polypeptide","PP","to","initiate","a","change","in","cell","activity","."),4383532). assertion_content_comment('tOboGo_PancreaticPPCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","pancreatic","PP","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","pancreatic","polypeptide-producing","cell","is","a","cell","in","the","pancreas","that","produces","pancreatic","polypeptide","."),4006472). assertion_content_comment('tOboGo_PancreaticPPCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and","functional","features","of","a","pancreatic","polypeptide-producing","cell",".","A","pancreatic","polypeptide-producing","cell","is","a","cell","in","the","pancreas","that","produces","pancreatic","polypeptide","."),4001954). assertion_content_comment('tOboGo_PancreaticPPCellFateCommitment',s("The","commitment","of","a","cell","to","a","pancreatic","PP","cell","fate","and","its","capacity","to","differentiate","into","a","pancreatic","PP","cell",".","A","pancreatic","polypeptide-producing","cell","is","a","cell","in","the","pancreas","that","produces","pancreatic","polypeptide","."),4006439). assertion_content_comment('tOboGo_PancreaticRibonucleaseActivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","RNA","to","3","'","-phosphomononucleotides","and","3","'","-phosphooligonucleotides","ending","in","C-P","or","U-P","with","2","'",",","3","'","-cyclic","phosphate","intermediates","."),4205050). assertion_content_comment('tOboGo_PancreaticStellateCellProliferation',s("The","multiplication","or","reproduction","of","pancreatic","stellate","cells",",","resulting","in","the","expansion","of","a","pancreatic","stellate","cell","population",".","Pancreatic","stellate","cells","are","found","in","the","periacinar","space","of","the","exocrine","pancreas","and","in","perivascular","and","periductal","regions","of","the","pancreas",",","and","have","long","cytoplasmic","processes","that","encircle","the","base","of","the","acinus","."),4140576). assertion_content_comment('tOboGo_PantetheineHydrolaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-pantetheine","+","H","(","2",")","O","=","(","R",")","-pantothenate","+","cysteamine","."),4257726). assertion_content_comment('tOboGo_PantetheineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","pantetheine","=","ADP","+","pantetheine","4","'","-phosphate","."),4271254). assertion_content_comment('tOboGo_PantothenaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-pantothenate","+","H","(","2",")","O","=","(","R",")","-pantoate","+","beta-alanine","."),4203988). assertion_content_comment('tOboGo_PantothenateBiosyntheticProcessFromValine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pantothenate",",","the","anion","of","pantothenic","acid",",","from","other","compounds",",","including","valine","."),4339031). assertion_content_comment('tOboGo_PantothenateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pantothenate",",","the","anion","of","pantothenic","acid",".","It","is","a","B","complex","vitamin","that","is","a","constituent","of","coenzyme","A","and","is","distributed","ubiquitously","in","foods","."),4294557). assertion_content_comment('tOboGo_PantothenateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pantothenate",",","the","anion","of","pantothenic","acid",".","It","is","a","B","complex","vitamin","that","is","a","constituent","of","coenzyme","A","and","is","distributed","ubiquitously","in","foods","."),4294539). assertion_content_comment('tOboGo_PantothenateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","pantothenate","=","ADP","+","D-4","'","-phosphopantothenate","."),4203974). assertion_content_comment('tOboGo_PantothenateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pantothenate",",","the","anion","of","pantothenic","acid",",","the","amide","of","beta-alanine","and","pantoic","acid",".","It","is","a","B","complex","vitamin","that","is","a","constituent","of","coenzyme","A","and","is","distributed","ubiquitously","in","foods","."),4294532). assertion_content_comment('tOboGo_Pantothenate_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","pantothenate","(","out",")","+","Na","+","(","out",")","=","pantothenate","(","in",")","+","Na","+","(","in",")"),4292212). assertion_content_comment('tOboGo_PantothenateTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","pantothenate","across","a","membrane","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Pantothenate","is","the","anion","of","pantothenic","acid",",","the","amide","of","beta-alanine","and","pantoic","acid",";","it","is","a","B","complex","vitamin","that","is","a","constituent","of","coenzyme","A","and","is","distributed","ubiquitously","in","foods","."),4292207). assertion_content_comment('tOboGo_PantothenateTransmembraneTransport',s("The","directed","movement","of","pantothenate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Pantothenate","is","the","anion","of","pantothenic","acid",",","the","amide","of","beta-alanine","and","pantoic","acid",";","it","is","a","B","complex","vitamin","that","is","a","constituent","of","coenzyme","A","and","is","distributed","ubiquitously","in","foods","."),4294267). assertion_content_comment('tOboGo_PantothenoylcysteineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","N-","[","(","R",")","-pantothenoyl","]","-L-cysteine","+","H","(","+",")","=","(","R",")","-pantetheine","+","CO","(","2",")"),4271184). assertion_content_comment('tOboGo_ParaferritinComplex',s("A","cytoplasmic","protein","complex","that","contains","integrin",",","mobilferrin","and","a","flavin","monooxygenase",",","is","capable","of","reducing","Fe","(","III",")","to","Fe","(","II",")","utilizing","NADPH",",","and","is","involved","in","iron","transport",".","Fe","(","II",")","is","required","in","the","cell","as","the","substrate","for","ferrochelatase","in","the","synthesis","of","heme","."),4178941). assertion_content_comment('tOboGo_ParahippocampalGyrusDevelopment',s("The","progression","of","the","parahippocampal","gyrus","over","time","from","its","initial","formation","until","its","mature","state",".","The","parahippocampal","gyrus","is","a","ridge","in","the","cerebral","cortex","."),4049232). assertion_content_comment('tOboGo_ParallelActinFilamentBundleAssembly',s("Assembly","of","actin","filament","bundles","in","which","the","filaments","are","tightly","packed","(","approximately","10-20","nm","apart",")","and","oriented","with","the","same","polarity","."),4306908). assertion_content_comment('tOboGo_ParamesonephricDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","paramesonephric","duct","over","time",",","from","its","formation","to","the","mature","structure",".","Mullerian","ducts","(","or","paramesonephric","ducts",")","are","paired","ducts","of","the","embryo","that","run","down","the","lateral","sides","of","the","urogenital","ridge","and","terminate","at","the","mullerian","eminence","in","the","primitive","urogenital","sinus",".","In","the","female",",","they","will","develop","to","form","the","fallopian","tubes",",","uterus",",","cervix",",","and","the","upper","portion","of","the","vagina",";","in","the","male",",","they","are","lost",".","These","ducts","are","made","of","tissue","of","mesodermal","origin","."),4155885). assertion_content_comment('tOboGo_ParamyosinFilamentAssemblyOrDisassembly',s("The","formation","or","disassembly","of","a","filament","composed","of","paramyosin","molecules","."),4136217). assertion_content_comment('tOboGo_ParanodalJunctionAssembly',s("Formation","of","the","junction","between","an","axon","and","the","glial","cell","that","forms","the","myelin","sheath",".","Paranodal","junctions","form","at","each","paranode",",","i.e",".","at","the","ends","of","the","unmyelinated","nodes","of","Ranvier","."),4061442). assertion_content_comment('tOboGo_ParanodalJunction',s("A","highly","specialized","cell-cell","junction","found","in","vertebrates",",","which","forms","between","a","neuron","and","a","glial","cell",",","and","has","structural","similarity","to","Drosophila","septate","junctions",".","It","flanks","the","node","of","Ranvier","in","myelinated","nerve","and","electrically","isolates","the","myelinated","from","unmyelinated","nerve","segments","and","physically","separates","the","voltage-gated","sodium","channels","at","the","node","from","the","cluster","of","potassium","channels","underneath","the","myelin","sheath","."),4347572). assertion_content_comment('tOboGo_ParanodeRegionOfAxon',s("An","axon","part","that","is","located","adjacent","to","the","nodes","of","Ranvier","and","surrounded","by","lateral","loop","portions","of","myelin","sheath","."),4066487). assertion_content_comment('tOboGo_Parasitism',s("An","interaction","between","two","organisms","living","together","in","more","or","less","intimate","association","in","a","relationship","in","which","association","is","disadvantageous","or","destructive","to","one","of","the","organisms","."),4157365). assertion_content_comment('tOboGo_Paraspeckles',s("Discrete","subnuclear","bodies","in","the","interchromatin","nucleoplasmic","space",",","often","located","adjacent","to","nuclear","specks",".","10-20","paraspeckles","are","typically","found","in","human","cell","nuclei","."),4312818). assertion_content_comment('tOboGo_ParasympatheticNervousSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","parasympathetic","nervous","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","parasympathetic","nervous","system","is","one","of","the","two","divisions","of","the","vertebrate","autonomic","nervous","system",".","Parasympathetic","nerves","emerge","cranially","as","pre","ganglionic","fibers","from","oculomotor",",","facial",",","glossopharyngeal","and","vagus","and","from","the","sacral","region","of","the","spinal","cord",".","Most","neurons","are","cholinergic","and","responses","are","mediated","by","muscarinic","receptors",".","The","parasympathetic","system","innervates",",","for","example",":","salivary","glands",",","thoracic","and","abdominal","viscera",",","bladder","and","genitalia","."),4043915). assertion_content_comment('tOboGo_ParathionCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","parathion",",","a","highly","toxic","organophosphate","compound",".","Degradation","of","parathion","by","sunlight","or","liver","enzymes","can","result","in","the","formation","of","the","active","compound","paraoxon","which","interferes","with","the","nervous","system","through","cholinesterase","inhibition","."),4240409). assertion_content_comment('tOboGo_ParathionMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","parathion",",","a","highly","toxic","organophosphate","compound","formerly","used","as","a","broad","spectrum","insecticide",",","acaricide",",","fumigant","and","nematocide",".","Degradation","of","parathion","by","sunlight","or","liver","enzymes","can","result","in","the","formation","of","the","active","compound","paraoxon","which","interferes","with","the","nervous","system","through","cholinesterase","inhibition","."),4240404). assertion_content_comment('tOboGo_ParathyroidGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","parathyroid","gland","over","time",",","from","its","formation","to","the","mature","structure",".","The","parathyroid","gland","is","an","organ","specialised","for","secretion","of","parathyroid","hormone","."),4109690). assertion_content_comment('tOboGo_ParathyroidHormoneReceptorActivity',s("Combining","with","parathyroid","hormone","to","initiate","a","change","in","cell","activity","."),4198968). assertion_content_comment('tOboGo_ParathyroidHormoneReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","parathyroid","hormone","receptor","."),4324155). assertion_content_comment('tOboGo_ParaxialMesodermalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","paraxial","mesoderm","cell","."),4102665). assertion_content_comment('tOboGo_ParaxialMesodermalCellFateCommitment',s("The","process","in","which","a","cell","becomes","committed","to","become","a","paraxial","mesoderm","cell","."),4102667). assertion_content_comment('tOboGo_ParaxialMesodermalCellFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","paraxial","mesoderm","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4102720). assertion_content_comment('tOboGo_ParaxialMesodermalCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","paraxial","mesoderm","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4102669). assertion_content_comment('tOboGo_ParaxialMesodermDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","paraxial","mesoderm","over","time",",","from","its","formation","to","the","mature","structure",".","The","paraxial","mesoderm","is","the","mesoderm","located","bilaterally","adjacent","to","the","notochord","and","neural","tube","."),4102616). assertion_content_comment('tOboGo_ParaxialMesodermFormation',s("The","process","that","gives","rise","to","the","paraxial","mesoderm",".","This","process","pertains","to","the","initial","formation","of","the","structure","from","unspecified","parts","."),4102663). assertion_content_comment('tOboGo_ParaxialMesodermMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","paraxial","mesoderm","are","generated","and","organized","."),4102618). assertion_content_comment('tOboGo_ParaxialMesodermStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","paraxial","mesoderm",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4102628). assertion_content_comment('tOboGo_ParenchymalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","parenchymal","cell",".","Parenchymal","cells","are","the","most","abundant","and","versatile","cells","in","plants",".","They","have","very","few","distinguishing","characteristics","and","botanists","classify","them","as","any","cell","type","that","cannot","be","assigned","to","any","other","structural","or","functional","class",".","They","can","redifferentiate","and","dedifferentiate","and","are","involved","in","storage",",","basic","metabolism","and","other","processes",".","The","cells","are","polyhedral",",","typically","with","thin",",","non-lignified","cellulose","cell","walls","and","nucleate","living","protoplasm",".","They","vary","in","size",",","form",",","and","wall","structure","."),4104720). assertion_content_comment('tOboGo_ParentalBehavior',s("A","reproductive","behavior","in","which","a","parent","cares","for","and","rears","offspring","."),4161104). assertion_content_comment('tOboGo_Parturition',s("The","reproductive","process","in","which","the","parent","is","separated","from","its","offspring","either","by","giving","birth","to","live","young","or","by","laying","eggs","."),4108081). assertion_content_comment('tOboGo_Parvulin',s("OBSOLETE",".","A","peptidyl-prolyl","isomerase","isolated","from","Escherichia","coli",".","It","does","not","have","any","function","as","an","immunophilin","."),4306941). assertion_content_comment('tOboGo_PASComplex',s("A","protein","complex","that","contains","a","phosphatidylinositol-3-phosphate","5-kinase","subunit","(","Fab1p","in","yeast",";","PIKfyve","in","mammals",")",",","a","kinase","activator",",","and","a","phosphatase",",","and","may","also","contain","additional","proteins",";","it","is","involved","in","regulating","the","synthesis","and","turnover","of","phosphatidylinositol","3",",","5-bisphosphate",".","In","mammals","the","complex","is","composed","of","PIKFYVE",",","FIG4","and","VAC14",".","In","yeast","it","is","composed","of","Atg18p",",","Fig4p",",","Fab1p",",","Vac14p","and","Vac7p","."),4132626). assertion_content_comment('tOboGo_PassiveEvasionOfHostImmuneResponse',s("Any","mechanism","of","immune","avoidance","that","does","not","directly","interfere","with","the","host","immune","system",";","for","example",",","some","viruses","enter","a","state","of","latency","where","their","protein","production","is","drastically","downregulated",",","meaning","that","they","are","not","detected","by","the","host","immune","system",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4317133). assertion_content_comment('tOboGo_PassiveEvasionOfImmuneResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","avoids","the","immune","response","of","a","second","organism","without","directly","interfering","with","the","second","organism","'","s","immune","system",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4079971). assertion_content_comment('tOboGo_PassiveEvasionOfSymbiontImmuneResponse',s("OBSOLETE",".","Any","mechanism","of","immune","avoidance","that","does","not","directly","interfere","with","the","symbiont","immune","system",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282393). assertion_content_comment('tOboGo_PassiveInductionOfHostHumoralImmuneResponseByVirus',s("The","unintentional","stimulation","by","a","virus","of","a","host","humoral","defense","response","to","viral","infection",",","as","part","of","the","viral","infectious","cycle","."),4357039). assertion_content_comment('tOboGo_PassiveInductionOfHostImmuneResponseByVirus',s("The","unintentional","stimulation","by","a","virus","of","a","host","defense","response","to","viral","infection",",","as","part","of","the","viral","infectious","cycle","."),4356579). assertion_content_comment('tOboGo_PassiveInductionOfHostInnateImmuneResponseByVirus',s("The","unintentional","stimulation","by","a","virus","of","an","innate","host","defense","response","to","viral","infection",",","as","part","of","the","viral","infectious","cycle","."),4356583). assertion_content_comment('tOboGo_PassiveProtonTransportDownTheElectrochemicalGradient',s("OBSOLETE",".","The","passive","movement","of","protons","from","areas","of","high","proton","concentration","and","electrical","potential","to","areas","where","concentration","and","electrical","potential","are","low","."),4295059). assertion_content_comment('tOboGo_PassiveSporeDispersalOnOrNearHost',s("Any","passive","process","in","which","a","symbiont","disseminates","its","spores",",","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154492). assertion_content_comment('tOboGo_PassiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","solute","from","one","side","of","the","membrane","to","the","other",",","down","the","solute","'","s","concentration","gradient","."),4107455). assertion_content_comment('tOboGo_PatchedBinding',s("Interacting","selectively","and","non-covalently","with","the","patched","(","ptc",")","protein",",","a","receptor","for","hedgehog","proteins","."),4214835). assertion_content_comment('tOboGo_PatchedLigandMaturation',s("The","posttranslational","modification","of","members","of","the","Hedgehog","family","of","signaling","proteins","in","order","for","Hedgehog","to","exert","its","biological","activity",".","These","modifications","include","cleavage","of","its","signal","sequence",",","autocatalytic","protein","cleavage","and","the","attachment","of","sterol","groups","."),4016143). assertion_content_comment('tOboGo_PaternalBehavior',s("Male","behaviors","associated","with","the","care","and","rearing","offspring","."),4316961). assertion_content_comment('tOboGo_Pathogenesis',s("The","set","of","specific","processes","that","generate","the","ability","of","an","organism","to","cause","disease","in","another","."),4233620). assertion_content_comment('tOboGo_PatternBinding',s("Interacting","selectively","and","non-covalently","with","a","repeating","or","polymeric","structure",",","such","as","a","polysaccharide","or","peptidoglycan","."),4157709). assertion_content_comment('tOboGo_PatterningOfBloodVessels',s("The","process","that","regulates","the","coordinated","growth","and","sprouting","of","blood","vessels","giving","rise","to","the","organized","vascular","system","."),3980794). assertion_content_comment('tOboGo_PatterningOfLymphVessels',s("The","process","that","regulates","the","coordinated","growth","and","sprouting","of","lymph","vessels","giving","rise","to","the","organized","lymphatic","system","."),4113853). assertion_content_comment('tOboGo_PatternOrientation',s("The","actions","or","reactions","of","an","individual","in","response","to","the","orientation","of","a","visual","pattern",".","This","is","exemplified","by","some","classes","of","insects","which","are","able","to","detect","and","learn","the","orientation","of","a","set","of","stripes","and","subsequently","behaviorally","discriminate","between","horizontal",",","vertical","or","45","degree","stripes","."),4235051). assertion_content_comment('tOboGo_PatternRecognitionReceptorActivity',s("Combining","with","a","molecular","pattern","based","on","a","repeating","or","polymeric","structure",",","such","as","a","polysaccharide","or","peptidoglycan",",","to","initiate","a","change","in","cell","activity",".","Such","molecular","patterns","are","sometimes","associated","with","potential","pathogens","."),4178378). assertion_content_comment('tOboGo_PatternRecognitionReceptorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","cell","surface","or","intracellular","pattern","recognition","receptor","(","PRR",")","Such","receptors","bind","for","molecular","patterns","based","on","a","repeating","or","polymeric","structures",",","like","those","of","polysaccharides","or","peptidoglycans",",","which","are","sometimes","associated","with","potential","pathogens","."),4075804). assertion_content_comment('tOboGo_PatternSpecificationInvolvedInKidneyDevelopment',s("Any","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","kidney","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4059042). assertion_content_comment('tOboGo_PatternSpecificationInvolvedInMesonephrosDevelopment',s("Any","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","mesonephros","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4133919). assertion_content_comment('tOboGo_PatternSpecificationInvolvedInMetanephrosDevelopment',s("Any","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","metanephros","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4124158). assertion_content_comment('tOboGo_PatternSpecificationInvolvedInPronephrosDevelopment',s("Any","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","pronephros","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4059048). assertion_content_comment('tOboGo_PatternSpecificationProcess',s("Any","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","an","organism","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),3980695). assertion_content_comment('tOboGo_PBAFComplex',s("A","SWI/SNF-type","complex","that","contains","the","ATPase","product","of","the","mammalian","BAF180","gene","."),4177474). assertion_content_comment('tOboGo_PCAFComplex',s("A","large","multiprotein","complex","that","possesses","histone","acetyltransferase","activity","and","is","involved","in","regulation","of","transcription",".","The","composition","is","similar","to","that","of","the","SAGA","complex",",","but","includes","fewer","Spt","and","Ada","proteins",",","and","more","TAFs","."),4345781). assertion_content_comment('tOboGo_PcGProteinComplex',s("A","chromatin-associated","multiprotein","complex","containing","Polycomb","Group","proteins",".","In","Drosophila",",","Polycomb","group","proteins","are","involved","in","the","long-term","maintenance","of","gene","repression",",","and","PcG","protein","complexes","associate","with","Polycomb","group","response","elements","(","PREs",")","in","target","genes","to","regulate","higher-order","chromatin","structure","."),4321854). assertion_content_comment('tOboGo_PCNAComplex',s("A","protein","complex","composed","of","three","identical","PCNA","monomers",",","each","comprising","two","similar","domains",",","which","are","joined","in","a","head-to-tail","arrangement","to","form","a","homotrimer",".","Forms","a","ring-like","structure","in","solution",",","with","a","central","hole","sufficiently","large","to","accommodate","the","double","helix","of","DNA",".","Originally","characterized","as","a","DNA","sliding","clamp","for","replicative","DNA","polymerases","and","as","an","essential","component","of","the","replisome",",","and","has","also","been","shown","to","be","involved","in","other","processes","including","Okazaki","fragment","processing",",","DNA","repair",",","translesion","DNA","synthesis",",","DNA","methylation",",","chromatin","remodeling","and","cell","cycle","regulation","."),4220133). assertion_content_comment('tOboGo_PDZDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","PDZ","domain","of","a","protein",",","a","domain","found","in","diverse","signaling","proteins","."),4311235). assertion_content_comment('tOboGo_PeBoWComplex',s("A","protein","complex","that","is","involved","in","coordinating","ribosome","biogenesis","with","cell","cycle","progression",".","In","human",",","it","is","composed","of","Pes1",",","Bop1",",","and","WDR12",";","in","Saccharomyces","the","proteins","are","known","as","Nop7p",",","Erb1","and","Ytm1","respectively","."),4131047). assertion_content_comment('tOboGo_PectateLyaseActivity',s("Catalysis","of","the","eliminative","cleavage","of","pectate","to","give","oligosaccharides","with","4-deoxy-alpha-D-gluc-4-enuronosyl","groups","at","their","non-reducing","ends","."),4310633). assertion_content_comment('tOboGo_PecticArabinanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","arabinan",",","a","polymer","with","an","alpha-","(","1-","&","gt",";","5",")","-linked","-L-arabinofuranose","(","Araf",")","backbone","that","can","be","substituted","with","Araf-alpha-","(","1-","&","gt",";","2",")","-",",","Araf-alpha-","(","1-","&","gt",";","3",")","-",",","and/or","Araf-alpha-","(","1-","&","gt",";","3",")","-Araf-alpha-","(","1-","&","gt",";","3",")","-side","chains",".","Arabinan","can","be","found","as","a","side","chain","of","the","pectin","rhamnogalacturonan","I","."),4333032). assertion_content_comment('tOboGo_PecticArabinogalactanIMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pectic","arabinogalactan","I",",","an","alpha-","(","1-","&","gt",";","4",")","-linked","D-galactopyranose","backbone","that","is","substituted","with","alpha-l-Araf","residues","via","the","O-3","of","the","D-galactose","residues",".","Arabinogalactan","I","can","be","found","as","a","side","chain","of","rhamnogalacturonan","I","."),4333042). assertion_content_comment('tOboGo_PecticGalactanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactan",",","a","polymer","of","D-galactosyl","units","that","can","be","found","as","a","side","chain","of","the","pectin","rhamnogalacturonan","I","."),4333061). assertion_content_comment('tOboGo_PecticMatrix',s("The","gel-like","pectin","matrix","consists","of","the","interlinked","acidic","and","neutral","pectin","networks","that","are","further","cross-linked","by","calcium","bridges",".","Pectins","consist","largely","of","long","chains","of","mostly","galacturonic","acid","units","(","typically","1",",","4","linkages","and","sometimes","methyl","esters",")","Three","major","pectic","polysaccharides","(","homogalacturonan",",","rhamnogalacturonan","I","and","rhamnogalacturonan","II",")","are","thought","to","occur","in","all","primary","cell","walls","."),4103974). assertion_content_comment('tOboGo_PectinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pectin",",","a","polymer","containing","a","backbone","of","alpha-1",",","4-linked","D-galacturonic","acid","residues","."),4102515). assertion_content_comment('tOboGo_PectinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pectin",",","a","polymer","containing","a","backbone","of","alpha-1",",","4-linked","D-galacturonic","acid","residues","."),4299650). assertion_content_comment('tOboGo_PectinesteraseActivity',s("Catalysis","of","the","reaction",":","pectin","+","n","H2O","=","n","methanol","+","pectate","."),4307848). assertion_content_comment('tOboGo_PectinesteraseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","any","pectinesterase","enzyme","."),4358544). assertion_content_comment('tOboGo_PectinLyaseActivity',s("Catalysis","of","the","eliminative","cleavage","of","(","14",")","-a-D-galacturonan","methyl","ester","to","give","oligosaccharides","with","4-deoxy-6-O-methyl-a-D-galact-4-enuronosyl","groups","at","their","nonreducing","ends","."),4369251). assertion_content_comment('tOboGo_PectinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pectin",",","a","group","of","galacturonic","acid-containing",",","water-soluble","colloidal","carbohydrates","of","high","molecular","weight","and","of","net","negative","charge","."),4102465). assertion_content_comment('tOboGo_PectoralFinDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pectoral","fin","over","time",",","from","its","formation","to","the","mature","structure","."),4071653). assertion_content_comment('tOboGo_PectoralFinMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","pectoral","fin","are","generated","and","organized",".","Pectoral","fins","are","bilaterally","paired","fins","mounted","laterally","and","located","behind","the","gill","covers","of","fish",".","These","fins","are","used","for","lateral","mobility","and","propulsion","."),4071673). assertion_content_comment('tOboGo_PedicelMucilageBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","mucilage","that","occur","in","the","flower","stem","."),4102547). assertion_content_comment('tOboGo_PedicelMucilageMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","mucilage","that","occur","in","the","flower","stem","."),4102536). assertion_content_comment('tOboGo_PegAndSocketContact',s("A","cell-cell","contact","zone","that","consists","of","membrane","invaginations","extending","from","either","cell",",","which","contain","tight-",",","gap-",",","and","adherens","junctions",".","Peg","and","socket","contacts","form","between","endothelial","cells","and","pericytes",",","and","between","lens","fiber","cells","."),4288159). assertion_content_comment('tOboGo_Pellicle',s("The","structure","enclosing","an","apicomplexan","parasite","cell",";","consists","of","the","cell","membrane","with","its","associated","infrastructure","of","microtubules",",","microfilaments","and","other","organelles","."),4041609). assertion_content_comment('tOboGo_PelvicFinDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pelvic","fin","over","time",",","from","its","formation","to","the","mature","structure","."),4071682). assertion_content_comment('tOboGo_PelvicFinMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","pelvic","fin","are","generated","and","organized",".","Pelvic","fins","are","bilaterally","paired","fins","mounted","in","a","ventral-lateral","position","on","most","fish",".","These","fins","are","used","primarily","for","lateral","mobility","and","propulsion","."),4071702). assertion_content_comment('tOboGo_PenetrationOfZonaPellucida',s("The","infiltration","by","sperm","of","the","zona","pellucida","to","reach","the","oocyte",".","The","process","involves","digestive","enzymes","from","a","modified","lysosome","called","the","acrosome",",","situated","at","the","head","of","the","sperm","."),4019191). assertion_content_comment('tOboGo_PenicillinAmidaseActivity',s("Catalysis","of","the","reaction",":","penicillin","+","H2O","=","a","carboxylate","+","6-aminopenicillanate","."),4247689). assertion_content_comment('tOboGo_PenicillinaseActivity',s("Catalysis","of","the","reaction",":","a","penicillin","+","H2O","=","a","substituted","beta-amino","acid","derivative","of","the","penicillin","."),4337866). assertion_content_comment('tOboGo_PenicillinBinding',s("Interacting","selectively","and","non-covalently","with","penicillin",",","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4253276). assertion_content_comment('tOboGo_PenicillinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4312983). assertion_content_comment('tOboGo_PenicillinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4066704). assertion_content_comment('tOboGo_PenicillinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system",".","Penicillins","are","produced","naturally","during","the","growth","of","various","microfungi","of","the","genera","Penicillium","and","Aspergillus","."),4066683). assertion_content_comment('tOboGo_PenicillopepsinActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","proteins","with","broad","specificity","similar","to","that","of","pepsin","A",",","preferring","hydrophobic","residues","at","P1","and","P1","'",",","but","also","cleaving","Gly20-Glu","in","the","B","chain","of","insulin",".","Clots","milk",",","and","activates","trypsinogen","."),4358856). assertion_content_comment('tOboGo_PenileErection',s("The","hardening",",","enlarging","and","rising","of","the","penis","which","often","occurs","in","the","sexually","aroused","male","and","enables","sexual","intercourse",".","Achieved","by","increased","inflow","of","blood","into","the","vessels","of","erectile","tissue",",","and","decreased","outflow","."),4094328). assertion_content_comment('tOboGo_PentachlorophenolBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pentachlorophenol",",","a","chlorinated","insecticide","and","fungicide","used","primarily","to","protect","timber","from","fungal","rot","and","wood","boring","insects",".","Pentachlorophenol","is","significantly","toxic","to","mammals",",","plants",",","and","many","microorganisms","."),4351805). assertion_content_comment('tOboGo_PentachlorophenolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pentachlorophenol",",","a","chlorinated","insecticide","and","fungicide","used","primarily","to","protect","timber","from","fungal","rot","and","wood","boring","insects",".","Pentachlorophenol","is","significantly","toxic","to","mammals",",","plants",",","and","many","microorganisms","."),4240438). assertion_content_comment('tOboGo_PentachlorophenolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pentachlorophenol",",","a","chlorinated","insecticide","and","fungicide","used","primarily","to","protect","timber","from","fungal","rot","and","wood","boring","insects",".","Pentachlorophenol","is","significantly","toxic","to","mammals",",","plants",",","and","many","microorganisms","."),4240431). assertion_content_comment('tOboGo_PentachlorophenolMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","pentachlorophenol","+","NADPH","+","H","+","+","O2","=","tetrachlorohydroquinone","+","NADP","+","+","chloride","."),4276446). assertion_content_comment('tOboGo_PentacyclicTriterpenoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pentacyclic","triterpenoid","compounds",",","terpenoids","with","six","isoprene","units","and","5","carbon","rings","."),4244956). assertion_content_comment('tOboGo_PentacyclicTriterpenoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pentacyclic","triterpenoid","compounds",",","terpenoids","with","six","isoprene","units","and","5","carbon","rings","."),4244889). assertion_content_comment('tOboGo_PentacyclicTriterpenoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pentacyclic","triterpenoid","compounds",",","terpenoids","with","six","isoprene","units","and","5","carbon","rings","."),4244886). assertion_content_comment('tOboGo_PentaerythritolTetranitrateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pentaerythritol","tetranitrate",",","C","(","CH2-O-NO2",")","4",",","a","substance","produced","for","use","as","an","explosive","and","a","vasodilator","."),4272804). assertion_content_comment('tOboGo_PentaerythritolTrinitrateReductaseActivity',s("Catalysis","of","the","reaction",":","pentaerythritol","trinitrate","+","NADPH","=","NADP","+","+","nitrate","+","pentaerythritol","dinitrate","."),4278983). assertion_content_comment('tOboGo_PentaleneneSynthaseActivity',s("Catalysis","of","the","reaction",":","2-trans",",","6-trans-farnesyl","diphosphate","=","diphosphate","+","pentalenene","."),4266233). assertion_content_comment('tOboGo_PentamericIgMImmunoglobulinComplex',s("A","circulating","form","of","IgM","consisting","of","a","pentamer","of","IgM","core","units","with","a","single","J","chain","polypeptide","."),4169670). assertion_content_comment('tOboGo_PentanamidaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","pentanamide","=","NH","(","4",")","(","+",")","+","valerate","."),4271173). assertion_content_comment('tOboGo_PentitolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pentitols",",","any","alditol","with","a","chain","of","five","carbon","atoms","in","the","molecule","."),4242354). assertion_content_comment('tOboGo_PentitolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pentitols",",","any","alditol","with","a","chain","of","five","carbon","atoms","in","the","molecule","."),4241158). assertion_content_comment('tOboGo_PentitolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pentitols",",","any","alditol","with","a","chain","of","five","carbon","atoms","in","the","molecule","."),4240224). assertion_content_comment('tOboGo_PentitolPhosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pentitol","phosphates",",","any","phosphorylated","alditol","with","a","chain","of","five","carbon","atoms","in","the","molecule","."),4191694). assertion_content_comment('tOboGo_PentoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pentose",",","any","monosaccharide","with","a","chain","of","five","carbon","atoms","in","the","molecule","."),4220871). assertion_content_comment('tOboGo_PentoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","pentose",",","any","monosaccharide","with","a","chain","of","five","carbon","atoms","in","the","molecule","."),4095946). assertion_content_comment('tOboGo_PentoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","pentose",",","any","monosaccharide","with","a","chain","of","five","carbon","atoms","in","the","molecule","."),4021211). assertion_content_comment('tOboGo_PentoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","pentose","sugar",",","a","monosaccharide","with","5","carbon","atoms",",","from","one","side","of","the","membrane","to","the","other","."),4289559). assertion_content_comment('tOboGo_PentoseTransport',s("The","directed","movement","of","pentoses","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","A","pentose","is","any","aldose","with","a","chain","of","five","carbon","atoms","in","the","molecule","."),4291032). assertion_content_comment('tOboGo_PentraxinBinding',s("Interacting","selectively","and","non-covalently","with","a","pentraxin",",","a","member","of","a","family","of","inflammatory","proteins","with","a","radially","symmetric","arrangement","of","five","identical",",","noncovalently","linked","chains","in","a","pentagonal","array","."),4246924). assertion_content_comment('tOboGo_PentraxinReceptorActivity',s("Combining","with","a","pentraxin","to","initiate","a","change","in","cell","activity","."),4246926). assertion_content_comment('tOboGo_PEPCarboxykinaseC4Photosynthesis',s("The","process","of","C4","photosynthesis",",","as","it","occurs","in","plants","in","which","the","enzyme","decarboxylating","C4","acids","in","the","bundle","sheath","is","phosphoenolpyruvate","carboxykinase","(","PEPCK",")"),4262768). assertion_content_comment('tOboGo_PepsinAActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",".","Preferential","cleavage",":","hydrophobic",",","preferably","aromatic",",","residues","in","P1","and","P1","'","positions",".","Cleaves","Phe1-Val2",",","Gln4-His5",",","Glu13-Ala14",",","Ala14-Leu15",",","Leu15-Tyr16",",","Tyr16-Leu17",",","Gly23-Phe24",",","Phe24-Phe25","and","Phe25-Tyr26","bonds","in","the","B","chain","of","insulin","."),4210424). assertion_content_comment('tOboGo_PeptidaseActivatorActivity',s("Increases","the","activity","of","a","peptidase",",","any","enzyme","that","catalyzes","the","hydrolysis","peptide","bonds","."),4156045). assertion_content_comment('tOboGo_PeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","a","peptide","bond",".","A","peptide","bond","is","a","covalent","bond","formed","when","the","carbon","atom","from","the","carboxyl","group","of","one","amino","acid","shares","electrons","with","the","nitrogen","atom","from","the","amino","group","of","a","second","amino","acid","."),4168559). assertion_content_comment('tOboGo_PeptidaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","peptidase",",","any","enzyme","that","catalyzes","the","hydrolysis","peptide","bonds","."),4160612). assertion_content_comment('tOboGo_PeptidaseRegulatorActivity',s("Modulates","the","activity","of","a","peptidase",",","any","enzyme","that","catalyzes","the","hydrolysis","peptide","bonds","."),4156008). assertion_content_comment('tOboGo_PeptideAmidation',s("The","posttranslational","conversion","of","C-terminal","glycine-extended","peptides","to","C-terminal","alpha-amidated","peptides",".","Occurs","to","over","half","of","all","peptide","hormones","to","give","bioactive","peptides",".","This","is","a","two","step","process","catalyzed","by","a","peptidyl-glycine","alpha-hydroxylating","monooxygenase","and","a","peptidyl-alpha-hydroxyglycine","alpha-amidating","lyase",".","In","some","organisms",",","this","process","is","catalyzed","by","two","separate","enzymes",",","whereas","in","higher","organisms",",","one","polypeptide","catalyzes","both","reactions","."),4361521). assertion_content_comment('tOboGo_PeptideAntibioticBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptides","with","antibiotic","activity","."),4308072). assertion_content_comment('tOboGo_PeptideAntibioticCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","peptides","with","antibiotic","activity","."),4308088). assertion_content_comment('tOboGo_PeptideAntibioticMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","peptides","with","antibiotic","activity","."),4308068). assertion_content_comment('tOboGo_PeptideAntigenAssemblyWithMHCClassIbProteinComplex',s("The","binding","of","a","peptide","antigen","to","the","antigen","binding","groove","of","an","MHC","class","Ib","protein","complex",".","Class","Ib","here","refers","to","non-classical","class","I","molecules",",","such","as","those","of","the","HLA-E","gene","family","."),3993952). assertion_content_comment('tOboGo_PeptideAntigenAssemblyWithMHCClassIIProteinComplex',s("The","binding","of","a","peptide","to","the","antigen","binding","groove","of","an","MHC","class","II","protein","complex","."),3996103). assertion_content_comment('tOboGo_PeptideAntigenAssemblyWithMHCClassIProteinComplex',s("The","binding","of","a","peptide","to","the","antigen","binding","groove","of","an","MHC","class","I","protein","complex",".","Class","I","here","refers","to","classical","class","I","molecules","."),3996072). assertion_content_comment('tOboGo_PeptideAntigenAssemblyWithMHCProteinComplex',s("The","binding","of","a","peptide","to","the","antigen","binding","groove","of","an","MHC","protein","complex","."),3993937). assertion_content_comment('tOboGo_PeptideAntigenBinding',s("Interacting","selectively","and","non-covalently","with","an","antigen","peptide",",","a","fragment","of","a","foreign","protein","derived","by","proteolysis","within","the","cell","."),4200156). assertion_content_comment('tOboGo_PeptideAntigenStabilizationActivity',s("OBSOLETE",".","Strengthening","of","a","bond","with","a","peptide","antigen",";","a","fragment","of","a","foreign","protein","derived","by","proteolysis","within","the","cell","."),4385072). assertion_content_comment('tOboGo_PeptideAntigenStabilization',s("Any","process","involved","in","maintaining","the","structure","and","integrity","of","a","peptide","antigen","and","preventing","it","from","being","degraded","."),4100828). assertion_content_comment('tOboGo_PeptideAntigenTransport',s("The","directed","movement","of","a","peptide","antigen","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","The","peptide","antigen","is","typically",",","but","not","always",",","processed","from","an","endogenous","or","exogenous","protein","."),4099792). assertion_content_comment('tOboGo_PeptideBinding',s("Interacting","selectively","and","non-covalently","with","peptides",",","any","of","a","group","of","organic","compounds","comprising","two","or","more","amino","acids","linked","by","peptide","bonds","."),4159866). assertion_content_comment('tOboGo_PeptideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptides",",","compounds","of","2","or","more","(","but","usually","less","than","100",")","amino","acids","where","the","alpha","carboxyl","group","of","one","is","bound","to","the","alpha","amino","group","of","another",".","This","may","include","the","translation","of","a","precursor","protein","and","its","subsequent","processing","into","a","functional","peptide","."),3997588). assertion_content_comment('tOboGo_PeptideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","peptides",",","compounds","of","2","or","more","(","but","usually","less","than","100",")","amino","acids","where","the","alpha","carboxyl","group","of","one","is","bound","to","the","alpha","amino","group","of","another","."),4229340). assertion_content_comment('tOboGo_PeptideDeformylaseActivity',s("Catalysis","of","the","reaction",":","formyl-L-methionyl","peptide","+","H2O","=","formate","+","methionyl","peptide","."),4316786). assertion_content_comment('tOboGo_PeptideDisulfideOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","a","peptide","with","reduced","sulfide","groups","=","a","peptide","with","oxidized","disulfide","bonds","."),4207488). assertion_content_comment('tOboGo_PeptideHormoneBinding',s("Interacting","selectively","and","non-covalently","with","any","peptide","with","hormonal","activity","in","animals","."),4268281). assertion_content_comment('tOboGo_PeptideHormoneProcessing',s("The","generation","of","a","mature","peptide","hormone","by","posttranslational","processing","of","a","prohormone","."),3991877). assertion_content_comment('tOboGo_PeptideHormoneReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","receptor","for","peptide","hormones","."),4073729). assertion_content_comment('tOboGo_PeptideHormoneSecretion',s("The","regulated","release","of","a","peptide","hormone","from","a","cell","or","organ","."),3991840). assertion_content_comment('tOboGo_PeptideHormone',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217009). assertion_content_comment('tOboGo_Peptide_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","peptide","(","out",")","+","H","+","(","out",")","=","peptide","(","in",")","+","H","+","(","in",")","Catalysis","of","the","transfer","of","a","peptide","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","hydrogen","ion","movement","."),4296312). assertion_content_comment('tOboGo_PeptideMatingPheromoneMaturationInvolvedInConjugationWithCellularFusion',s("The","formation","of","a","mature","peptide","mating","pheromone","by","proteolysis","and/or","modification","of","a","peptide","precursor",",","occurring","in","the","context","of","conjugation","with","cellular","fusion","."),4128493). assertion_content_comment('tOboGo_PeptideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","peptides",",","compounds","of","two","or","more","amino","acids","where","the","alpha","carboxyl","group","of","one","is","bound","to","the","alpha","amino","group","of","another","."),3997584). assertion_content_comment('tOboGo_PeptideModification',s("The","covalent","alteration","of","one","or","more","amino","acid","residues","within","a","peptide",",","resulting","in","a","change","in","the","properties","of","that","peptide","."),4319068). assertion_content_comment('tOboGo_PeptidePheromoneExportInvolvedInConjugation',s("The","directed","movement","of","a","peptide","pheromone","out","of","a","cell","by","a","secretion","or","export","pathway","used","solely","for","the","export","of","peptide","pheromones","that","contributes","to","the","union","or","introduction","of","genetic","information","from","compatible","mating","types","that","results","in","a","genetically","different","individual",".","Conjugation","requires","direct","cellular","contact","between","the","organisms","."),4125631). assertion_content_comment('tOboGo_PeptidePheromoneExportInvolvedInConjugationWithCellularFusion',s("The","directed","movement","of","a","peptide","pheromone","out","of","a","cell","by","a","secretion","or","export","pathway","used","solely","for","the","export","of","peptide","pheromones","that","contributes","to","a","conjugation","process","that","results","in","the","union","of","cellular","and","genetic","information","from","compatible","mating","types","."),4125634). assertion_content_comment('tOboGo_PeptidePheromoneExport',s("The","directed","movement","of","a","peptide","pheromone","out","of","a","cell","by","a","secretion","or","export","pathway","used","solely","for","the","export","of","peptide","pheromones","."),4125626). assertion_content_comment('tOboGo_PeptidePheromoneMaturation',s("The","generation","of","a","mature",",","active","peptide","pheromone","via","processes","unique","to","its","processing","and","modification",".","An","example","of","this","process","is","found","in","Saccharomyces","cerevisiae","."),4128489). assertion_content_comment('tOboGo_PeptideReceptorActivity',s("Combining","with","an","extracellular","or","intracellular","peptide","to","initiate","a","change","in","cell","activity","."),4159868). assertion_content_comment('tOboGo_PeptideSecretion',s("The","controlled","release","of","a","peptide","from","a","cell","or","group","of","cells","."),3991815). assertion_content_comment('tOboGo_PeptideStabilizationActivity',s("OBSOLETE",".","Strengthening","of","a","bond","between","peptides",".","Peptides","are","compounds","of","two","or","more","amino","acids","where","the","alpha","carboxyl","group","of","one","is","bound","to","the","alpha","amino","group","of","another","."),4385061). assertion_content_comment('tOboGo_PeptideStabilization',s("Any","process","involved","in","maintaining","the","structure","and","integrity","of","a","peptide","and","preventing","it","from","being","degraded","."),4100824). assertion_content_comment('tOboGo_PeptideTransporterActivity',s("Enables","the","directed","movement","of","peptides",",","compounds","of","two","or","more","amino","acids","where","the","alpha","carboxyl","group","of","one","is","bound","to","the","alpha","amino","group","of","another",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4168306). assertion_content_comment('tOboGo_PeptideTransport',s("The","directed","movement","of","peptides",",","compounds","of","two","or","more","amino","acids","where","the","alpha","carboxyl","group","of","one","is","bound","to","the","alpha","amino","group","of","another",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3991812). assertion_content_comment('tOboGo_PeptideYYReceptorActivity',s("Combining","with","gut","peptide","YY","to","initiate","a","change","in","cell","activity","."),4383495). assertion_content_comment('tOboGo_PeptidoglycanBinding',s("Interacting","selectively","and","non-covalently",",","in","a","non-covalent","manner",",","with","peptidoglycan",",","any","of","a","class","of","glycoconjugates","found","in","bacterial","cell","walls","."),4302785). assertion_content_comment('tOboGo_PeptidoglycanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptidoglycans",",","any","of","a","class","of","glycoconjugates","found","in","bacterial","cell","walls","."),4024192). assertion_content_comment('tOboGo_PeptidoglycanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","peptidoglycans",",","any","of","a","class","of","glycoconjugates","found","in","bacterial","cell","walls","."),4121920). assertion_content_comment('tOboGo_PeptidoglycanGlycosyltransferaseActivity',s("Catalysis","of","the","reaction",":","[","GlcNAc-","(","1",",","4",")","-Mur2Ac","(","oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala",")","]","(","n",")","-diphosphoundecaprenol","+","GlcNAc-","(","1",",","4",")","-Mur2Ac","(","oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala",")","-diphosphoundecaprenol","=","[","GlcNAc-","(","1",",","4",")","-Mur2Ac","(","oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala",")","]","(","n","+","1",")","-diphosphoundecaprenol","+","undecaprenyl","diphosphate","."),4247669). assertion_content_comment('tOboGo_PeptidoglycanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","peptidoglycans",",","any","of","a","class","of","glycoconjugates","found","only","in","bacterial","cell","walls","and","consisting","of","strands","of","glycosaminoglycan","cross-linked","by","oligopeptides","to","form","a","huge","and","rigid","network","."),4024118). assertion_content_comment('tOboGo_PeptidoglycanPeptideTransporterActivity',s("Enables","the","directed","movement","of","peptidoglycan","peptides","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Peptidoglycan","peptides","are","the","oligopeptides","found","in","peptidoglycan","networks","which","cross-link","the","polysaccharide","chains","."),4290529). assertion_content_comment('tOboGo_PeptidoglycanReceptorActivity',s("Combining","with","a","peptidoglycan","to","initiate","a","change","in","cell","activity","."),4302787). assertion_content_comment('tOboGo_PeptidoglycanRecognitionProteinSignalingPathway',s("The","series","of","molecular","signals","initiated","by","binding","of","peptidoglycan","to","a","receptor","on","the","surface","of","the","target","cell","and","mediated","by","Imd",".","The","main","outcome","of","the","Imd","signaling","is","the","production","of","antimicrobial","peptides","."),4113620). assertion_content_comment('tOboGo_PeptidoglycanSynthetaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4247679). assertion_content_comment('tOboGo_PeptidoglycanTransporterActivity',s("Enables","the","directed","movement","of","peptidoglycans",",","a","class","of","glycoconjugates","found","in","bacterial","cell","walls",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4290507). assertion_content_comment('tOboGo_PeptidoglycanTransport',s("The","directed","movement","of","peptidoglycans",",","a","class","of","glycoconjugates","found","in","bacterial","cell","walls",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293980). assertion_content_comment('tOboGo_PeptidoglycanTurnover',s("The","continual","breakdown","and","regeneration","of","peptidoglycan","required","to","maintain","the","cell","wall","."),4257689). assertion_content_comment('tOboGo_PeptidylamidoglycolateLyaseActivity',s("Catalysis","of","the","reaction",":","peptidylamidoglycolate","=","peptidyl","amide","+","glyoxylate","."),4204059). assertion_content_comment('tOboGo_PeptidylglycineMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","peptidyl-glycine","+","ascorbate","+","O2","=","peptidyl","(","2-hydroxyglycine",")","+","dehydroascorbate","+","H2O","."),4205434). assertion_content_comment('tOboGo_PeptidyltransferaseActivity',s("Catalysis","of","the","reaction",":","peptidyl-tRNA","(","1",")","+","aminoacyl-tRNA","(","2",")","=","tRNA","(","1",")","+","peptidylaminoacyl-tRNA","(","2",")"),4345581). assertion_content_comment('tOboGo_PerceptionOfMechanicalStimulus',s("OBSOLETE",".","The","series","of","events","by","which","a","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4261418). assertion_content_comment('tOboGo_PerceptionOfRateOfMovement',s("The","series","of","events","by","which","an","organism","senses","the","speed","and","direction","of","movement","of","the","body","and","its","parts","."),4238376). assertion_content_comment('tOboGo_PerceptionOfStaticPosition',s("The","perception","of","the","orientation","of","different","parts","of","the","body","with","respect","to","one","another","."),4238386). assertion_content_comment('tOboGo_PerchlorateReductaseActivity',s("Catalysis","of","the","reaction",":","perchlorate","+","2","H","+","+","2","e-","=","chlorate","+","H2O","."),4348860). assertion_content_comment('tOboGo_PeriarbuscularMembrane',s("A","host-derived","membrane","surrounding","the","symbiont","arbuscule","during","symbiosis","."),4084008). assertion_content_comment('tOboGo_PeribacteroidFluid',s("The","soluble","material","inside","the","peribacteroid","membrane",",","but","outside","of","the","bacteroid",",","within","a","bacteroid-containing","symbiosome","."),4095054). assertion_content_comment('tOboGo_PeribacteroidMembrane',s("A","membrane","that","surrounds","one","or","more","bacteroids","(","such","as","nitrogen-fixing","bacteroids","within","legume","root","nodule","cells",")"),4094950). assertion_content_comment('tOboGo_PericanalicularVesicle',s("A","membrane-bounded","vesicle","found","near","the","apical",",","or","pericanalicular",",","membrane","of","a","hepatocyte",";","contains","proteins","involved","in","bile","salt","transport","and","other","fluid","and","solute","transport","processes","."),4341311). assertion_content_comment('tOboGo_PericardialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","mesodermal","cell","acquires","the","specialized","features","of","a","pericardial","cell",".","In","insects",",","pericardial","cells","are","loosely","arranged","non-myogenic","cells","that","flank","the","cardioblasts","and","probably","act","in","the","filtration","of","hemolymph","."),4234497). assertion_content_comment('tOboGo_PericardialNephrocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","structural","and/or","functional","features","of","a","pericardial","nephrocyte",".","A","pericardial","nephrocyte","is","an","insect","renal","cell","that","filters","hemolymph","and","is","found","with","other","pericardial","nephrocytes","in","two","rows","flanking","the","dorsal","vessel",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","and","its","subsequent","development","to","the","mature","state","."),4261647). assertion_content_comment('tOboGo_PericardiumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pericardium","over","time",",","from","its","formation","to","the","mature","structure",".","The","pericardium","is","a","double-walled","sac","that","contains","the","heart","and","the","roots","of","the","aorta",",","vena","cava","and","the","pulmonary","artery","."),4005967). assertion_content_comment('tOboGo_PericardiumMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","pericardium","is","generated","and","organized","."),4005969). assertion_content_comment('tOboGo_PericentriolarMaterial',s("A","network","of","small","fibers","that","surrounds","the","centrioles","in","cells",";","contains","the","microtubule","nucleating","activity","of","the","centrosome","."),3973818). assertion_content_comment('tOboGo_PerichromatinFibrils',s("Structures","of","variable","diameter","visible","in","the","nucleoplasm","by","electron","microscopy",",","mainly","observed","near","the","border","of","condensed","chromatin",".","The","fibrils","are","enriched","in","RNA",",","and","are","believed","to","be","sites","of","pre-mRNA","splicing","and","polyadenylylation","representing","the","in","situ","form","of","nascent","transcripts","."),4008021). assertion_content_comment('tOboGo_Perikaryon',s("The","portion","of","the","cell","soma","(","cell","body",")","that","excludes","the","nucleus","."),4093127). assertion_content_comment('tOboGo_PerineurialGlialGrowth',s("Glial","cell","growth","that","occurs","in","the","perineurium",",","a","cell","layer","that","ensheaths","projections","of","peripheral","nerves",",","such","as","motor","axons","."),4306468). assertion_content_comment('tOboGo_PerineuronalNet',s("A","dense","extracellular","matrix","(","ECM",")","structure","that","forms","around","many","neuronal","cell","bodies","and","dendrites","late","in","development","and","is","responsible","for","synaptic","stabilization","in","the","adult","brain","."),4157149). assertion_content_comment('tOboGo_PerinuclearEndoplasmicReticulum',s("The","portion","of","endoplasmic","reticulum",",","the","intracellular","network","of","tubules","and","cisternae",",","that","occurs","near","the","nucleus",".","The","lumen","of","the","perinuclear","endoplasmic","reticulum","is","contiguous","with","the","nuclear","envelope","lumen","(","also","called","perinuclear","space",")",",","the","region","between","the","inner","and","outer","nuclear","membranes","."),4074234). assertion_content_comment('tOboGo_PerinuclearRegionOfCytoplasm',s("Cytoplasm","situated","near",",","or","occurring","around",",","the","nucleus","."),4065174). assertion_content_comment('tOboGo_PerinuclearTheca',s("A","condensed","cytoplasmic","structure","that","covers","the","nucleus","of","mammalian","spermatozoa","except","for","a","narrow","zone","around","the","insertion","of","the","tail",".","It","shows","two","distinct","regions",",","a","subacrosomal","layer","and",",","continuing","caudally","beyond","the","acrosomic","system",",","the","postacrosomal","sheath",".","The","perinuclear","theca","has","been","considered","a","cytoskeletal","scaffold","responsible","for","maintaining","the","overall","architecture","of","the","mature","sperm","head",";","however",",","recent","studies","indicate","that","the","bulk","of","its","constituent","proteins","are","not","traditional","cytoskeletal","proteins","but","rather","a","variety","of","cytosolic","proteins","."),4065185). assertion_content_comment('tOboGo_PerinucleolarChromocenter',s("A","chromocenter","adjacent","to","the","nucleolus","."),4332063). assertion_content_comment('tOboGo_PeriodicPartitioningByPairRuleGene',s("Allocation","of","cells","to","parasegments","in","the","embryo",",","through","the","action","of","overlapping","series","of","pair","rule","gene","activities","."),4234633). assertion_content_comment('tOboGo_PeriodicPartitioning',s("The","regionalization","process","that","divides","the","spatial","regions","of","an","embryo","into","serially","repeated","regions","."),4019374). assertion_content_comment('tOboGo_PeripheralBCellAnergy',s("Any","process","contributing","to","anergy",",","a","state","of","functional","inactivation","that","occurs","as","part","of","tolerance","induction",",","in","peripheral","B","cells","."),3993825). assertion_content_comment('tOboGo_PeripheralBCellDeletion',s("The","deletion","of","B","cells","by","apoptosis","occurring","as","part","of","peripheral","tolerance","induction","and","B","cell","selection","."),3993790). assertion_content_comment('tOboGo_PeripheralBCellNegativeSelection',s("Any","process","leading","to","negative","selection","of","B","cells","in","the","periphery","."),4379461). assertion_content_comment('tOboGo_PeripheralBCellPositiveSelection',s("Any","process","leading","to","positive","selection","of","B","cells","in","the","periphery",".","Positive","selection","is","the","process","in","which","B","or","T","cells","are","selected","to","survive","based","on","signaling","through","their","antigen","receptors","."),4379448). assertion_content_comment('tOboGo_PeripheralBCellReceptorEditing',s("The","process","that","takes","place","mainly","in","germinal","center","B","cells","in","which","a","large","number","of","mutations","are","generated","in","the","heavy","chain","and","light","chain","V-region","genes","and","their","immediately","surrounding","introns","in","order","to","increase","antibody","diversity","and","contribute","to","affinity","maturation","."),4379551). assertion_content_comment('tOboGo_PeripheralBCellSelection',s("Any","B","cell","selection","process","that","occurs","in","the","periphery","."),3993118). assertion_content_comment('tOboGo_PeripheralBCellToleranceInduction',s("Tolerance","induction","of","mature","B","cells","in","the","peripheral","lymphoid","tissues",":","the","blood",",","lymph","nodes",",","spleen",",","and","mucosal-associated","lymphoid","tissue","."),3993716). assertion_content_comment('tOboGo_PeripheralMammaryGlandBudEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","epithelial","cell","of","the","mammary","placode","becomes","an","epithelial","cell","at","the","periphery","of","the","mammary","gland","bud",".","Cells","at","the","periphery","of","the","bud","are","larger","that","those","of","the","surrounding","epithelium","and","are","arranged","concentrically","."),4160996). assertion_content_comment('tOboGo_PeripheralNervousSystemAxonEnsheathment',s("The","process","in","which","a","Schwann","cell","membrane","closes","around","an","axon","in","the","peripheral","nervous","system",".","This","can","be","a","myelinating","or","a","non-myelinating","neuron-glial","interaction","."),4053315). assertion_content_comment('tOboGo_PeripheralNervousSystemAxonRegeneration',s("The","regrowth","of","axons","outside","the","central","nervous","system","(","outside","the","brain","and","spinal","cord",")","following","an","axonal","injury","."),4036321). assertion_content_comment('tOboGo_PeripheralNervousSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","peripheral","nervous","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","peripheral","nervous","system","is","one","of","the","two","major","divisions","of","the","nervous","system",".","Nerves","in","the","PNS","connect","the","central","nervous","system","(","CNS",")","with","sensory","organs",",","other","organs",",","muscles",",","blood","vessels","and","glands","."),4014756). assertion_content_comment('tOboGo_PeripheralNervousSystemMyelinFormation',s("The","process","in","which","the","wraps","of","cell","membrane","that","constitute","myelin","are","laid","down","around","an","axon","by","an","oligodendrocyte","in","the","peripheral","nervous","system","."),4054576). assertion_content_comment('tOboGo_PeripheralNervousSystemMyelinMaintenance',s("The","process","in","which","the","structure","and","material","content","of","mature","peripheral","nervous","system","myelin","is","kept","in","a","functional","state","."),4054520). assertion_content_comment('tOboGo_PeripheralNervousSystemNeuronAxonogenesis',s("Generation","of","a","long","process","from","a","neuron","whose","cell","body","resides","in","the","peripheral","nervous","system",".","The","axon","carries","action","potential","from","the","cell","body","towards","target","cells","."),4105872). assertion_content_comment('tOboGo_PeripheralNervousSystemNeuronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","neuron","whose","cell","body","is","located","in","the","peripheral","nervous","system",",","from","initial","commitment","of","the","cell","to","a","neuronal","fate",",","to","the","fully","functional","differentiated","neuron","."),4105870). assertion_content_comment('tOboGo_PeripheralNervousSystemNeuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuron","whose","cell","body","resides","in","the","peripheral","nervous","system","."),4105868). assertion_content_comment('tOboGo_PeripheralTCellToleranceInduction',s("Tolerance","induction","of","T","cells","in","the","periphery",",","in","this","case",",","any","location","in","the","body","other","than","the","thymus","."),4000323). assertion_content_comment('tOboGo_PeripheralToleranceInduction',s("Tolerance","induction","in","the","peripheral","lymphoid","tissues",":","blood",",","lymph","nodes",",","spleen",",","and","mucosal-associated","lymphoid","tissues","."),3993700). assertion_content_comment('tOboGo_PeripheralToleranceInductionToNonselfAntigen',s("Tolerance","induction","to","nonself","antigens","in","the","periphery","."),4381037). assertion_content_comment('tOboGo_PeripheralToleranceInductionToSelfAntigen',s("Tolerance","induction","to","self","antigens","in","the","peripheral","lymphoid","tissues",":","blood",",","lymph","nodes",",","spleen",",","and","mucosal-associated","lymphoid","tissues","."),4381057). assertion_content_comment('tOboGo_PeripheralToMembraneOfMembraneFraction',s("Peripheral","to","that","fraction","of","cells",",","prepared","by","disruptive","biochemical","methods",",","that","includes","the","plasma","and","other","membranes",";","can","be","extracted","from","membrane","fraction","with","high","concentrations","of","salt","or","high","pH","."),4362980). assertion_content_comment('tOboGo_Peripherin',s("OBSOLETE",".","Peripherin","is","a","type","III","intermediate","filament","protein","found","in","neurons","of","the","peripheral","nervous","system","."),4299908). assertion_content_comment('tOboGo_PeriplasmicFlagellum',s("Flagellar","filaments","located","in","the","periplasmic","space",";","characterized","in","spirochetes",",","in","which","they","are","essential","for","shape","and","motility",".","Composed","of","a","core","surrounded","by","two","sheath","layers",",","the","flagella","rotate","to","allow","migration","of","the","cell","through","viscous","media",",","which","would","not","be","possible","using","external","flagella","."),4107737). assertion_content_comment('tOboGo_PeriplasmicSpaceOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","periplasmic","space",",","the","region","between","the","inner","(","cytoplasmic",")","and","outer","membrane","in","Gram-negative","bacteria",",","or","the","inner","membrane","and","cell","wall","in","fungi","."),4325641). assertion_content_comment('tOboGo_PeriplasmicSpace',s("The","region","between","the","inner","(","cytoplasmic",")","and","outer","membrane","(","Gram-negative","Bacteria",")","or","inner","membrane","and","cell","wall","(","Fungi",")"),4048859). assertion_content_comment('tOboGo_Peristalsis',s("A","wavelike","sequence","of","involuntary","muscular","contraction","and","relaxation","that","passes","along","a","tubelike","structure",",","such","as","the","intestine",",","impelling","the","contents","onwards","."),4158159). assertion_content_comment('tOboGo_PeroxidaseActivity',s("Catalysis","of","the","reaction",":","donor","+","hydrogen","peroxide","=","oxidized","donor","+","2","H2O","."),4203694). assertion_content_comment('tOboGo_PeroxidaseReaction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228854). assertion_content_comment('tOboGo_PeroxiredoxinActivity',s("Catalysis","of","the","reaction",":","2","R","'","-SH","+","ROOH","=","R","'","-S-S-R","'","+","H2O","+","ROH","."),4157103). assertion_content_comment('tOboGo_PeroxisomalFattyAcylTransporter',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4291844). assertion_content_comment('tOboGo_PeroxisomalMatrix',s("The","volume","contained","within","the","membranes","of","a","peroxisome",";","in","many","cells","the","matrix","contains","a","crystalloid","core","largely","composed","of","urate","oxidase","."),4074716). assertion_content_comment('tOboGo_PeroxisomalMembraneDisassembly',s("The","controlled","breakdown","of","the","membranes","of","cargo-carrying","vesicles","formed","during","peroxisome","degradation","."),4046349). assertion_content_comment('tOboGo_PeroxisomalMembrane',s("The","lipid","bilayer","surrounding","a","peroxisome","."),4007313). assertion_content_comment('tOboGo_PeroxisomalMembraneTransporter',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4219689). assertion_content_comment('tOboGo_PeroxisomalMembraneTransport',s("The","directed","movement","of","substances","to",",","from","or","across","the","peroxisomal","membrane","."),4294467). assertion_content_comment('tOboGo_PeroxisomalPart',s("Any","constituent","part","of","a","peroxisome",",","a","small",",","membrane-bounded","organelle","that","uses","dioxygen","(","O2",")","to","oxidize","organic","molecules",";","contains","some","enzymes","that","produce","and","others","that","degrade","hydrogen","peroxide","(","H2O2",")"),4007310). assertion_content_comment('tOboGo_PeroxisomalTransport',s("Transport","of","substances","into",",","out","of","or","within","a","peroxisome",",","a","small",",","membrane-bounded","organelle","that","uses","dioxygen","(","O2",")","to","oxidize","organic","molecules","."),4040578). assertion_content_comment('tOboGo_PeroxisomeDegradation',s("The","process","in","which","peroxisomes","are","delivered","to","the","vacuole","and","degraded","in","response","to","changing","nutrient","conditions","."),4046338). assertion_content_comment('tOboGo_PeroxisomeFission',s("The","division","of","a","mature","peroxisome","within","a","cell","to","form","two","or","more","separate","peroxisome","compartments","."),4040650). assertion_content_comment('tOboGo_PeroxisomeInheritance',s("The","acquisition","of","peroxisomes","by","daughter","cells","from","the","mother","cell","after","replication",".","In","Saccharomyces","cerevisiae",",","the","number","of","peroxisomes","cells","is","fairly","constant",";","a","subset","of","the","organelles","are","targeted","and","segregated","to","the","bud","in","a","highly","ordered",",","vectorial","process",".","Efficient","segregation","of","peroxisomes","from","mother","to","bud","is","dependent","on","the","actin","cytoskeleton",",","and","active","movement","of","peroxisomes","along","actin","filaments","is","driven","by","the","class","V","myosin","motor","protein",",","Myo2p","."),4300860). assertion_content_comment('tOboGo_PeroxisomeIntegralMembraneReceptor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4214935). assertion_content_comment('tOboGo_PeroxisomeLocalization',s("Any","process","in","which","a","peroxisome","is","transported","to",",","and/or","maintained","in",",","a","specific","location",".","A","peroxisome","is","a","small","membrane-bounded","organelle","that","uses","dioxygen","(","O2",")","to","oxidize","organic","molecules","."),4159802). assertion_content_comment('tOboGo_PeroxisomeMembraneBiogenesis',s("The","process","in","which","a","peroxisome","membrane","is","synthesized",",","aggregates",",","and","bonds","together","."),4040704). assertion_content_comment('tOboGo_PeroxisomeMembraneTargetingSequenceBinding',s("Interacting","selectively","and","non-covalently","with","a","peroxisomal","membrane","targeting","sequence",",","any","of","several","sequences","of","amino","acids","within","a","protein","that","can","act","as","a","signal","for","the","localization","of","the","protein","into","the","peroxisome","membrane","."),4338615). assertion_content_comment('tOboGo_PeroxisomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","peroxisome",".","A","peroxisome","is","a","small",",","membrane-bounded","organelle","that","uses","dioxygen","(","O2",")","to","oxidize","organic","molecules","."),4040606). assertion_content_comment('tOboGo_PeroxisomeProliferatorActivatedReceptorBinding',s("Interacting","selectively","and","non-covalently","with","any","of","the","peroxisome","proliferator","activated","receptors",",","alpha",",","beta","or","gamma","."),4316077). assertion_content_comment('tOboGo_PeroxisomeProliferatorActivatedReceptorSignalingPathway',s("The","series","of","molecular","signals","initiated","by","binding","of","a","ligand","to","any","of","the","peroxisome","proliferator","activated","receptors","(","alpha",",","beta","or","gamma",")","in","the","nuclear","membrane",",","and","ending","with","the","initiation","or","termination","of","the","transcription","of","target","genes","."),4083353). assertion_content_comment('tOboGo_PeroxisomeReceptor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4214863). assertion_content_comment('tOboGo_Peroxisome',s("A","small",",","membrane-bounded","organelle","that","uses","dioxygen","(","O2",")","to","oxidize","organic","molecules",";","contains","some","enzymes","that","produce","and","others","that","degrade","hydrogen","peroxide","(","H2O2",")"),4007307). assertion_content_comment('tOboGo_PeroxisomeTargetingSequenceBinding',s("Interacting","selectively","and","non-covalently","with","a","peroxisomal","targeting","sequence",",","any","of","several","sequences","of","amino","acids","within","a","protein","that","can","act","as","a","signal","for","the","localization","of","the","protein","into","the","peroxisome","."),4214914). assertion_content_comment('tOboGo_PeroxisomeTargetingSignalReceptorComplex',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4219913). assertion_content_comment('tOboGo_PeroxynitriteReductaseActivity',s("Catalysis","of","the","reaction",":","2","R-SH","+","ONOO-","=","R-SS-R","+","NO2-","+","H2O","."),4157110). assertion_content_comment('tOboGo_PetalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","petal","over","time",",","from","its","formation","to","the","mature","structure","."),4032412). assertion_content_comment('tOboGo_PetalEpidermisPatterning',s("The","regionalization","process","that","regulates","the","coordinated","growth","and","establishes","the","non-random","spatial","arrangement","of","the","cells","in","the","petal","epidermis","."),4181166). assertion_content_comment('tOboGo_PetalFormation',s("The","process","that","gives","rise","to","the","petal",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4032416). assertion_content_comment('tOboGo_PetalMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","petal","are","generated","and","organized","."),4032414). assertion_content_comment('tOboGo_PetalStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","petal",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4101904). assertion_content_comment('tOboGo_PetalVascularTissuePatternFormation',s("Vascular","tissue","pattern","formation","as","it","occurs","in","the","petal","of","vascular","plants","."),4182631). assertion_content_comment('tOboGo_PetromyzonolSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phospho-5","'","-adenylyl","sulfate","+","5alpha-cholane-3alpha",",","7alpha",",","12alpha",",","24-tetrol","=","3alpha",",","7alpha",",","12alpha-trihydroxy-5alpha-cholan-24-yl","sulfate","+","adenosine","3","'",",","5","'","-diphosphate","+","H","(","+",")"),4343581). assertion_content_comment('tOboGo_PeyerSPatchDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","Peyer","'","s","patches","over","time",",","from","their","formation","to","the","mature","structure",".","Peyer","'","s","patches","are","typically","found","as","nodules","associated","with","gut","epithelium","with","distinct","internal","structures","including","B-","and","T-zones","for","the","activation","of","lymphocytes","."),4135606). assertion_content_comment('tOboGo_PeyerSPatchMorphogenesis',s("The","process","in","which","a","Peyer","'","s","patch","is","generated","and","organized",".","Peyer","'","s","patches","are","typically","found","as","nodules","associated","with","gut","epithelium","with","distinct","internal","structures","including","B-","and","T-zones","for","the","activation","of","lymphocytes","."),4135618). assertion_content_comment('tOboGo_PGranuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","polar","granules",",","cytoplasmic",",","non-membranous","RNA/protein","complex","aggregates","in","the","primordial","germ","cells","of","many","higher","eukaryotes","."),4052194). assertion_content_comment('tOboGo_PGranule',s("A","small","cytoplasmic",",","non-membranous","RNA/protein","complex","aggregates","in","the","primordial","germ","cells","of","many","higher","eukaryotes","."),4093001). assertion_content_comment('tOboGo_PhageAssembly',s("A","late","phase","of","bacteriophage","replication","during","which","all","the","components","necessary","for","the","formation","of","a","mature","virion","collect","at","a","particular","site","in","the","bacterial","cell","and","the","basic","structure","of","the","virus","particle","is","formed","."),4316229). assertion_content_comment('tOboGo_PhageShock',s("A","response","by","bacterial","cells","to","a","variety","of","stresses","including","filamentous","phage","infection",",","mislocalization","of","envelope","proteins",",","extremes","of","temperature",",","osmolarity","or","ethanol","concentration",",","and","the","presence","of","proton","ionophores","such","as","carbonylcyanide","m-chlorophenylhydrazone","(","CCCP",")",",","that","involves","expression","of","the","phage","shock","protein","operon",",","and","acts","to","protect","the","bacterial","cells","from","damage","."),4257245). assertion_content_comment('tOboGo_PhageTerminaseComplex',s("A","complex","of","a","large","and","small","subunit","which","catalyze","the","packaging","of","DNA","into","phage","heads",".","Note","that","not","all","phage","terminases","have","this","structure",",","some","exist","as","single","polypeptides","."),4325097). assertion_content_comment('tOboGo_PhagocyticCup',s("An","invagination","of","the","cell","membrane","formed","by","an","actin","dependent","process","during","phagocytosis",".","Following","internalization","it","is","converted","into","a","phagosome","."),4384443). assertion_content_comment('tOboGo_PhagocyticVesicleLumen',s("The","volume","enclosed","by","the","membrane","of","a","phagocytic","vesicle","."),4073764). assertion_content_comment('tOboGo_PhagocyticVesicleMembrane',s("The","lipid","bilayer","surrounding","a","phagocytic","vesicle","."),4051705). assertion_content_comment('tOboGo_PhagocyticVesicle',s("A","membrane-bounded","intracellular","vesicle","that","arises","from","the","ingestion","of","particulate","material","by","phagocytosis","."),4051662). assertion_content_comment('tOboGo_PhagocytosisEngulfment',s("The","internalization","of","bacteria",",","immune","complexes","and","other","particulate","matter","or","of","an","apoptotic","cell","by","phagocytosis",",","including","the","membrane","and","cytoskeletal","processes","required",",","which","involves","one","of","three","mechanisms",":","zippering","of","pseudopods","around","a","target","via","repeated","receptor-ligand","interactions",",","sinking","of","the","target","directly","into","plasma","membrane","of","the","phagocytosing","cell",",","or","induced","uptake","via","an","enhanced","membrane","ruffling","of","the","phagocytosing","cell","similar","to","macropinocytosis","."),4011593). assertion_content_comment('tOboGo_PhagocytosisRecognition',s("The","initial","step","in","phagocytosis","involving","adhesion","to","bacteria",",","immune","complexes","and","other","particulate","matter",",","or","an","apoptotic","cell","and","based","on","recognition","of","factors","such","as","bacterial","cell","wall","components",",","opsonins","like","complement","and","antibody","or","protein","receptors","and","lipids","like","phosphatidyl","serine",",","and","leading","to","intracellular","signaling","in","the","phagocytosing","cell","."),4011583). assertion_content_comment('tOboGo_PhagocytosisTriggeredByActivationOfImmuneResponseCellSurfaceActivatingReceptor',s("Phagocytosis","occurring","as","the","result","of","a","ligand","binding","an","immune","response","cell","surface","activating","receptor","."),4381515). assertion_content_comment('tOboGo_PhagolysosomeAssemblyInvolvedInApoptoticCellClearance',s("The","process","in","which","a","phagosome",",","a","vesicle","formed","by","phagocytosis",",","fuses","with","a","lysosome","as","a","part","of","apoptotic","cell","clearance","."),4151147). assertion_content_comment('tOboGo_PhagolysosomeAssembly',s("The","process","that","results","in","the","fusion","of","a","phagosome",",","a","vesicle","formed","by","phagocytosis",",","with","a","lysosome","."),3986763). assertion_content_comment('tOboGo_Phagolysosome',s("A","membrane-bounded","intracellular","vesicle","formed","by","maturation","of","an","early","phagosome","following","the","ingestion","of","particulate","material","by","phagocytosis",";","during","maturation",",","phagosomes","acquire","markers","of","late","endosomes","and","lysosomes","."),4080021). assertion_content_comment('tOboGo_PhagosomeAcidificationInvolvedInApoptoticCellClearance',s("Any","process","that","reduces","the","pH","of","the","phagosome",",","measured","by","the","concentration","of","the","hydrogen","ion",",","and","occurs","as","a","part","of","apoptotic","cell","clearance","."),4151240). assertion_content_comment('tOboGo_PhagosomeAcidification',s("Any","process","that","reduces","the","pH","of","the","phagosome",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4151198). assertion_content_comment('tOboGo_PhagosomeFormation',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4232327). assertion_content_comment('tOboGo_PhagosomeMaturationInvolvedInApoptoticCellClearance',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","arrangement","of","constituent","parts","of","a","phagosome","within","a","cell","and","contributes","to","apoptotic","cell","clearance",".","Phagosome","maturation","begins","with","endocytosis","and","formation","of","the","early","phagosome","and","ends","with","the","formation","of","the","hybrid","organelle",",","the","phagolysosome","."),4151145). assertion_content_comment('tOboGo_PhagosomeMaturation',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","arrangement","of","constituent","parts","of","a","phagosome","within","a","cell",".","Phagosome","maturation","begins","with","endocytosis","and","formation","of","the","early","phagosome","and","ends","with","the","formation","of","the","hybrid","organelle",",","the","phagolysosome","."),3986761). assertion_content_comment('tOboGo_PHAGranule',s("An","inclusion","body","located","in","the","cytoplasm","that","consists","of","polyhydroxyalkanoate","(","PHA",")","molecules","and","associated","proteins",",","surrounded","by","a","phospholipid","monolayer",";","the","proteins","include","PHA","synthase",",","PHA","depolymerase","and","3HB-oligomer","hydroxylase",",","phasins","(","PhaPs",")",",","which","are","thought","to","be","the","major","structural","proteins","of","the","membrane","surrounding","the","inclusion",",","and","the","regulator","of","phasin","expression","PhaR","."),4180245). assertion_content_comment('tOboGo_PharyngealMuscleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pharyngeal","muscle","over","time",",","from","its","formation","to","the","mature","structure",".","A","pharyngeal","muscle","is","any","muscle","that","forms","part","of","the","pharynx","."),4093400). assertion_content_comment('tOboGo_PharyngealPumping',s("The","contraction","and","relaxation","movements","of","the","pharyngeal","muscle","that","mediate","feeding","in","nematodes","."),4094160). assertion_content_comment('tOboGo_PharyngealSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pharyngeal","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","pharyngeal","system","is","a","transient","embryonic","complex","that","is","specific","to","vertebrates",".","It","comprises","the","pharyngeal","arches",",","bulges","of","tissues","of","mesoderm","and","neural","crest","derivation","through","which","pass","nerves","and","pharyngeal","arch","arteries",".","The","arches","are","separated","internally","by","pharyngeal","pouches",",","evaginations","of","foregut","endoderm",",","and","externally","by","pharyngeal","clefts",",","invaginations","of","surface","ectoderm",".","The","development","of","the","system","ends","when","the","stucture","it","contributes","to","are","forming",":","the","thymus",",","thyroid",",","parathyroids",",","maxilla",",","mandible",",","aortic","arch",",","cardiac","outflow","tract",",","external","and","middle","ear","."),4109119). assertion_content_comment('tOboGo_PharynxDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","pharynx","from","an","initial","condition","to","its","mature","state",".","The","pharynx","is","the","part","of","the","digestive","system","immediately","posterior","to","the","mouth","."),4093389). assertion_content_comment('tOboGo_PhaseicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phaseic","acid","(","PA",")",",","a","catabolite","of","the","plant","hormone","abscisic","acid","(","ABA",")"),4332042). assertion_content_comment('tOboGo_PhaseollidinHydrataseActivity',s("Catalysis","of","the","reaction",":","phaseollidin","hydrate","=","H","(","2",")","O","+","phaseollidin","."),4369365). assertion_content_comment('tOboGo_PhasicSmoothMuscleContraction',s("A","process","in","which","force","is","generated","within","phasic","smooth","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","In","the","phasic","smooth","muscle",",","the","muscle","contraction","occurs","without","an","ordered","sarcomeric","structure",".","Phasic","smooth","muscle","contraction","occurs","in","a","series","of","discrete","contractions","and","relaxations","."),4158146). assertion_content_comment('tOboGo_PHDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","PH","domain","(","pleckstrin","homology",")","of","a","protein",",","a","domain","of","about","100","residues","that","occurs","in","a","wide","range","of","proteins","involved","in","intracellular","signaling","or","as","constituents","of","the","cytoskeleton","."),4316902). assertion_content_comment('tOboGo_PHElevation',s("Any","process","that","increases","the","internal","pH","of","an","organism",",","part","of","an","organism","or","a","cell",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4286542). assertion_content_comment('tOboGo_PhenanthreneBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phenanthrene",",","a","tricyclic","aromatic","hydrocarbon","."),4354113). assertion_content_comment('tOboGo_PhenanthreneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenanthrene",",","a","tricyclic","aromatic","hydrocarbon","."),4272774). assertion_content_comment('tOboGo_PhenanthreneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","phenanthrene","+","NADH","+","H","+","+","O2","=","NAD","+","+","cis-3",",","4-dihydroxy-3",",","4-dihydrophenanthrene","."),4278921). assertion_content_comment('tOboGo_PhenanthreneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phenanthrene",",","a","tricyclic","aromatic","hydrocarbon","used","in","explosives","and","in","the","synthesis","of","dyes","and","drugs",".","Although","phenanthrene","is","not","mutagenic","or","carcinogenic",",","it","has","been","shown","to","be","toxic","to","marine","diatoms",",","gastropods",",","mussels",",","crustaceans",",","and","fish","."),4272769). assertion_content_comment('tOboGo_PhenanthrolGlycosyltransferaseActivity',s("Catalysis","of","the","reaction",":","phenanthrol","+","glucose","=","phenanthryl-beta-D-glucopyranoside","+","H2O","."),4237140). assertion_content_comment('tOboGo_PhenanthrolSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","phenanthrol","+","X-SO3","(","-",")","=","HX","+","phenanthrylsulfate","."),4237149). assertion_content_comment('tOboGo_PhenazineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","phenazine","antibiotic",",","a","polycyclic","pyrazine","with","two","nitrogen","atoms","in","the","ring","."),4373918). assertion_content_comment('tOboGo_Phenethylamine_OxygenOxidoreductaseDeaminatingActivity',s("Catalysis","of","the","reaction",":","phenylethylamine","+","O2","+","H2O","=","phenylacetaldehyde","+","NH3","+","hydrogen","peroxide","+","H","+"),4186689). assertion_content_comment('tOboGo_PhenolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phenol",",","a","compound","that","consists","of","a","benzene","ring","with","one","attached","hydroxyl","group","."),4158852). assertion_content_comment('tOboGo_PhenolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenol",",","a","compound","that","consists","of","a","benzene","ring","with","one","attached","hydroxyl","group","."),4158877). assertion_content_comment('tOboGo_PhenolicPhthiocerolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phenolic","phthiocerol",",","a","phthiocerol","derivative","having","a","4-hydroxyphenyl","substituent","at","the","29-position","."),4074305). assertion_content_comment('tOboGo_PhenolKinaseActivity',s("Catalysis","of","the","reaction",":","phenol","+","X-HPO3-","=","XH","+","phenylphosphate","."),4275197). assertion_content_comment('tOboGo_PhenolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phenol",",","a","compound","that","consists","of","a","benzene","ring","with","one","attached","hydroxyl","group","."),4158842). assertion_content_comment('tOboGo_PhenolWaterDikinaseActivity',s("Catalysis","of","the","reaction",":","phenol","+","MgATP","+","H2O","=","phenylphosphate","+","MgAMP","+","orthophosphate","."),4326037). assertion_content_comment('tOboGo_PhenylacetaldehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","phenylacetaldehyde","+","NAD","+","+","H2O","=","phenylacetate","+","NADH","+","H","+"),4247635). assertion_content_comment('tOboGo_PhenylacetaldoximeDehydrataseActivity',s("Catalysis","of","the","reaction",":","(","trans",")","-phenylacetaldoxime","=","H","(","2",")","O","+","phenylacetonitrile","."),4273967). assertion_content_comment('tOboGo_PhenylacetateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenylacetate","."),4334476). assertion_content_comment('tOboGo_PhenylacetateHydroxylaseActivity',s("Catalysis","of","the","reaction",":","phenylacetate","+","NADH","+","O2","=","NAD","+","+","OH-","+","2-hydroxyphenylacetate","."),4275980). assertion_content_comment('tOboGo_PhenylacetoneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADPH","+","O","(","2",")","+","phenylacetone","=","benzyl","acetate","+","H","(","2",")","O","+","NADP","(","+",")"),4342207). assertion_content_comment('tOboGo_PhenylalanineAdenylyltransferaseActivity',s("Catalysis","of","the","reaction",":","L-phenylalanine","+","ATP","=","N-adenylyl-L-phenylalanine","+","diphosphate","+","2","H","(","+",")"),4271069). assertion_content_comment('tOboGo_PhenylalanineCatabolicProcessToPhosphoenolpyruvate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenylalanine","into","other","compounds",",","including","phosphoenolpyruvate","."),4242897). assertion_content_comment('tOboGo_PhenylalanineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","L-phenylalanine","=","phenylethylamine","+","CO2","."),4271133). assertion_content_comment('tOboGo_PhenylalanineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-phenylalanine","+","H2O","+","NAD","+","=","phenylpyruvate","+","NH3","+","NADH","."),4271147). assertion_content_comment('tOboGo_Phenylalanine_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","phenylalanine","(","out",")","+","H","+","(","out",")","=","phenylalanine","(","in",")","+","H","+","(","in",")"),4292305). assertion_content_comment('tOboGo_PhenylalanineTransport',s("The","directed","movement","of","phenylalanine",",","2-amino-3-phenylpropanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293782). assertion_content_comment('tOboGo_PhenylalkylamineBinding',s("Interacting","selectively","and","non-covalently","with","phenylalkylamine","or","any","of","its","derivatives","."),4245796). assertion_content_comment('tOboGo_PhenylboronicAcidMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","phenylboronic","acid","+","O2","+","2","H","+","+","2","e-","=","phenol","+","B","(","OH",")","3","."),4348714). assertion_content_comment('tOboGo_PhenylcoumaranBenzylicEtherReductaseActivity',s("Catalysis","of","the","NADPH-dependent","7-O-4","'","reduction","of","phenylcoumaran","lignans","to","the","corresponding","diphenols",";","for","example",",","catalysis","of","the","reaction",":","dehydrodiconiferyl","alcohol","+","NADPH","+","H","+","=","isodihydrodehydrodiconiferyl","alcohol","+","NADP","."),4334836). assertion_content_comment('tOboGo_PhenylethylamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phenylethylamine",",","an","amine","with","pharmacological","properties","similar","to","those","of","amphetamine",",","occurs","naturally","as","a","neurotransmitter","in","the","brain",",","and","is","present","in","chocolate","and","oil","of","bitter","almonds","."),4313416). assertion_content_comment('tOboGo_PhenylethylamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenylethylamine",",","an","amine","with","pharmacological","properties","similar","to","those","of","amphetamine",",","occurs","naturally","as","a","neurotransmitter","in","the","brain",",","and","is","present","in","chocolate","and","oil","of","bitter","almonds","."),4243594). assertion_content_comment('tOboGo_PhenylethylamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phenylethylamine",",","an","amine","with","pharmacological","properties","similar","to","those","of","amphetamine",",","occurs","naturally","as","a","neurotransmitter","in","the","brain",",","and","is","present","in","chocolate","and","oil","of","bitter","almonds","."),4243591). assertion_content_comment('tOboGo_PhenylglyoxylateDehydrogenaseAcylatingActivity',s("Catalysis","of","the","reaction",":","CoA","+","NAD","(","+",")","+","phenylglyoxylate","=","benzoyl-CoA","+","CO","(","2",")","+","NADH","."),4365839). assertion_content_comment('tOboGo_PhenylmercuryAcetateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenylmercury","acetate",",","an","organomercurial","compound","composed","of","a","mercury","atom","attached","to","a","benzene","ring","and","an","acetate","group","."),4242695). assertion_content_comment('tOboGo_PhenylmercuryAcetateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phenylmercury","acetate",",","an","organomercurial","compound","composed","of","a","mercury","atom","attached","to","a","benzene","ring","and","an","acetate","group","."),4242677). assertion_content_comment('tOboGo_PhenylphosphateCarboxylaseActivity',s("Catalysis","of","the","reaction",":","phenylphosphate","+","CO2","+","H2O","=","H","+","+","phosphate","+","4-hydroxybenzoate","."),4273253). assertion_content_comment('tOboGo_PhenylpropanoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aromatic","derivatives","of","trans-cinnamic","acid","."),4022317). assertion_content_comment('tOboGo_PhenylpropanoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","aromatic","derivatives","of","trans-cinnamic","acid","."),4315546). assertion_content_comment('tOboGo_PhenylpropanoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","aromatic","derivatives","of","trans-cinnamic","acid","."),4022275). assertion_content_comment('tOboGo_PhenylPropionateUptakeUniporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","phenyl","propionate","(","out",")","=","phenyl","propionate","(","in",")"),4293338). assertion_content_comment('tOboGo_PhenylpyruvateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","phenylpyruvate","=","phenylacetaldehyde","+","CO2","."),4271122). assertion_content_comment('tOboGo_PhenylpyruvateTautomeraseActivity',s("Catalysis","of","the","reaction",":","keto-phenylpyruvate","=","enol-phenylpyruvate","."),4263199). assertion_content_comment('tOboGo_PhenylserineAldolaseActivity',s("Catalysis","of","the","reaction",":","L-threo-3-phenylserine","=","benzaldehyde","+","glycine","."),4263187). assertion_content_comment('tOboGo_PheophorbideAOxygenaseActivity',s("Catalysis","of","the","reaction",":","pheophorbide","a","+","reduced","ferredoxin","+","2","O2","=","red","chlorophyll","catabolite","+","oxidized","ferredoxin","+","H2O","."),4334857). assertion_content_comment('tOboGo_PheophoridaseActivity',s("Catalysis","of","the","reaction",":","pheophorbide","a","+","H2O","=","pyropheophorbide","a","+","methanol","+","CO2",".","The","reaction","occurs","in","two","steps",";","pheophoridase","catalyzes","the","conversion","of","pheophorbide","a","to","a","precursor","of","pyropheophorbide","a",",","C-13","(","2",")","-carboxylpyropheophorbide","a",",","by","demethylation",",","and","then","the","precursor","is","decarboxylated","non-enzymatically","to","yield","pyropheophorbide","a","."),4378546). assertion_content_comment('tOboGo_PheophytinaseActivity',s("Catalysis","of","the","reaction",":","pheophytin","+","H2O","=","phytol","+","pheophorbide","."),4181646). assertion_content_comment('tOboGo_PheromoneActivity',s("The","activity","of","binding","to","and","activating","specific","cell","surface","receptors",",","thereby","inducing","behavioral",",","developmental",",","or","physiological","response","(","s",")","from","a","responding","organism","or","cell",".","The","substance","may","be","released","or","retained","on","the","cell","surface",".","Pheromones","may","serve","as","a","specific","attractant",",","social","communicator",",","or","sexual","stimulant","."),4216894). assertion_content_comment('tOboGo_PheromoneBinding',s("Interacting","selectively","and","non-covalently","with","a","pheromone",",","a","substance",",","or","characteristic","mixture","of","substances",",","that","is","secreted","and","released","by","an","organism","and","detected","by","a","second","organism","of","the","same","or","a","closely","related","species",",","in","which","it","causes","a","specific","reaction",",","such","as","a","definite","behavioral","reaction","or","a","developmental","process","."),4218234). assertion_content_comment('tOboGo_PheromoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pheromones",",","a","substance","that","is","secreted","and","released","by","an","organism","and","detected","by","a","second","organism","of","the","same","or","a","closely","related","species",",","in","which","it","causes","a","specific","reaction",",","such","as","a","definite","behavioral","reaction","or","a","developmental","process","."),4314869). assertion_content_comment('tOboGo_PheromoneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pheromones",",","a","substance","that","is","secreted","and","released","by","an","organism","and","detected","by","a","second","organism","of","the","same","or","a","closely","related","species",",","in","which","it","causes","a","specific","reaction",",","such","as","a","definite","behavioral","reaction","or","a","developmental","process","."),4314887). assertion_content_comment('tOboGo_PheromoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pheromones",",","a","substance","that","is","secreted","and","released","by","an","organism","and","detected","by","a","second","organism","of","the","same","or","a","closely","related","species",",","in","which","it","causes","a","specific","reaction",",","such","as","a","definite","behavioral","reaction","or","a","developmental","process","."),4314856). assertion_content_comment('tOboGo_PheromoneReceptorActivity',s("Combining","with","a","pheromone","to","initiate","a","change","in","cell","activity","."),4198518). assertion_content_comment('tOboGo_PhialideDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","phialides","over","time",",","from","its","formation","to","the","mature","structure",".","Phialides","are","specialized","cells","that","bud","from","the","ends","of","metulae","on","the","conidiophore","tip",".","Chains","of","conidia",",","or","asexual","spores",",","develop","from","the","phialide","tips","."),4132377). assertion_content_comment('tOboGo_PhlobapheneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phlobaphenes",",","red","pigments","with","oligomeric","or","polymeric","structure","derived","from","the","flavonoid","intermediate","flavan-4-ols","."),4283845). assertion_content_comment('tOboGo_PhlobapheneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phlobaphenes",",","red","pigments","with","oligomeric","or","polymeric","structure","derived","from","the","flavonoid","intermediate","flavan-4-ols","."),4283842). assertion_content_comment('tOboGo_PhloemDevelopment',s("The","formation","of","the","principal","food-conducting","tissue","of","a","vascular","plant","."),4104675). assertion_content_comment('tOboGo_PhloemLoading',s("The","process","of","loading","sucrose","into","the","sieve","tube","or","companion","cell","of","the","phloem","for","long","distance","transport","from","source","to","sink","."),4261899). assertion_content_comment('tOboGo_PhloemOrXylemHistogenesis',s("The","process","whose","specific","outcome","is","the","progression","of","phloem","and/or","xylem","over","time",",","from","formation","to","the","mature","structure",".","An","example","of","this","process","is","found","in","Arabidopsis","thaliana","."),4104670). assertion_content_comment('tOboGo_PhloemTransport',s("The","directed","movement","of","substances",",","into",",","out","of","or","within","a","cell",",","either","in","a","phloem","tissue","or","in","the","phloem","membrane","."),4335634). assertion_content_comment('tOboGo_PhloretinHydrolaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","phloretin","=","H","(","+",")","+","phloretate","+","phloroglucinol","."),4263051). assertion_content_comment('tOboGo_PhloroglucinolReductaseActivity',s("Catalysis","of","the","reaction",":","dihydrophloroglucinol","+","NADP","(","+",")","=","H","(","+",")","+","NADPH","+","phloroglucinol","."),4278468). assertion_content_comment('tOboGo_PhloroisovalerophenoneSynthaseActivity',s("Catalysis","of","the","reaction",":","isovaleryl-CoA","+","3","malonyl-CoA","=","4","CoASH","+","3","CO2","+","3-methyl-1-","(","2",",","4",",","6-trihydroxyphenyl",")","butan-1-one","."),4277784). assertion_content_comment('tOboGo_PhorbolEsterReceptorActivity',s("Combining","with","a","phorbol","ester","to","initiate","a","change","in","cell","activity","."),4361345). assertion_content_comment('tOboGo_PhosphagenBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphagen",",","any","of","a","group","of","guanidine","phosphates","that","occur","in","muscle","and","can","be","used","to","regenerate","ATP","from","ADP","during","muscular","contraction","."),4230148). assertion_content_comment('tOboGo_PhosphagenCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphagen",",","any","of","a","group","of","guanidine","phosphates","that","occur","in","muscle","and","can","be","used","to","regenerate","ATP","from","ADP","during","muscular","contraction","."),4230177). assertion_content_comment('tOboGo_PhosphagenMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphagen",",","any","of","a","group","of","guanidine","phosphates","that","occur","in","muscle","and","can","be","used","to","regenerate","ATP","from","ADP","during","muscular","contraction","."),4230124). assertion_content_comment('tOboGo_PhosphataseActivatorActivity',s("Increases","the","activity","of","a","phosphatase",",","an","enzyme","which","catalyzes","of","the","removal","of","a","phosphate","group","from","a","substrate","molecule","."),4157027). assertion_content_comment('tOboGo_PhosphataseActivity',s("Catalysis","of","the","hydrolysis","of","phosphoric","monoesters",",","releasing","inorganic","phosphate","."),4176029). assertion_content_comment('tOboGo_PhosphataseBinding',s("Interacting","selectively","and","non-covalently","with","any","phosphatase","."),4232587). assertion_content_comment('tOboGo_PhosphataseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","phosphatase",",","an","enzyme","which","catalyzes","of","the","removal","of","a","phosphate","group","from","a","substrate","molecule","."),4200237). assertion_content_comment('tOboGo_PhosphataseRegulatorActivity',s("Modulates","the","activity","of","a","phosphatase",",","an","enzyme","which","catalyzes","of","the","removal","of","a","phosphate","group","from","a","substrate","molecule","."),4157004). assertion_content_comment('tOboGo_PhosphateAcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","phosphate","=","CoA","+","acetyl","phosphate","."),4247646). assertion_content_comment('tOboGo_PhosphateBinding',s("Interacting","selectively","and","non-covalently","with","phosphate","."),4314044). assertion_content_comment('tOboGo_PhosphateButyryltransferaseActivity',s("Catalysis","of","the","reaction",":","butanoyl-CoA","+","phosphate","=","butanoyl","phosphate","+","CoA","."),4263105). assertion_content_comment('tOboGo_PhosphateCarrierActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","phosphate","(","cyt",")","+","H","+","(","cyt",")","=","phosphate","(","mitochondrion",")","+","H","+","(","mitochondrion",")"),4296449). assertion_content_comment('tOboGo_Phosphate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","phosphate","(","out",")","+","H","+","(","out",")","=","phosphate","(","in",")","+","H","+","(","in",")"),4216072). assertion_content_comment('tOboGo_Phosphate_HydrogenSymporter',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4216076). assertion_content_comment('tOboGo_PhosphateIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","phosphate","ions","within","an","organism","or","cell","."),4221988). assertion_content_comment('tOboGo_PhosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","phosphate","group",",","the","anion","or","salt","of","any","phosphoric","acid","."),3972301). assertion_content_comment('tOboGo_PhosphateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","phosphate","(","PO4","3-",")","ions","from","one","side","of","a","membrane","to","the","other","."),4020456). assertion_content_comment('tOboGo_PhosphateTransmembraneTransport',s("The","directed","movement","of","phosphate","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4141293). assertion_content_comment('tOboGo_PhosphateTransport',s("The","directed","movement","of","phosphate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4035673). assertion_content_comment('tOboGo_PhosphatidateCytidylyltransferaseActivity',s("Catalysis","of","the","reaction",":","CTP","+","phosphatidate","=","diphosphate","+","CDP-diacylglycerol","."),4203739). assertion_content_comment('tOboGo_PhosphatidatePhosphataseActivity',s("Catalysis","of","the","reaction",":","a","3-sn-phosphatidate","+","H2O","=","a","1",",","2-diacyl-sn-glycerol","+","phosphate","."),4246119). assertion_content_comment('tOboGo_PhosphatidicAcidBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidic","acid",",","any","of","a","class","of","glycerol","phosphate","in","which","both","the","remaining","hydroxyl","groups","of","the","glycerol","moiety","are","esterified","with","fatty","acids","."),4172898). assertion_content_comment('tOboGo_PhosphatidicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidic","acid",",","any","derivative","of","glycerol","phosphate","in","which","both","the","remaining","hydroxyl","groups","of","the","glycerol","moiety","are","esterified","with","fatty","acids","."),4230529). assertion_content_comment('tOboGo_PhosphatidicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphatidic","acid",",","any","derivative","of","glycerol","phosphate","in","which","both","the","remaining","hydroxyl","groups","of","the","glycerol","moiety","are","esterified","with","fatty","acids","."),4230525). assertion_content_comment('tOboGo_PhosphatidylcholineBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylcholine",",","a","class","of","glycophospholipids","in","which","a","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","choline","."),4319911). assertion_content_comment('tOboGo_PhosphatidylcholineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidylcholines",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","choline","."),4178821). assertion_content_comment('tOboGo_PhosphatidylcholineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphatidylcholines",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","choline","."),4037936). assertion_content_comment('tOboGo_PhosphatidylcholineDesaturaseActivity',s("Catalysis","of","the","reaction",":","1-acyl-2-oleoyl-sn-glycero-3-phosphocholine","+","NAD","(","+",")","=","1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine","+","H","(","+",")","+","NADH","."),4263077). assertion_content_comment('tOboGo_PhosphatidylcholineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphatidylcholines",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","choline",".","They","are","important","constituents","of","cell","membranes","."),4037901). assertion_content_comment('tOboGo_PhosphatidylcholinePhospholipaseCActivity',s("Catalysis","of","the","reaction",":","phosphatidylcholine","+","H2O","=","1",",","2-diacylglycerol","+","a","choline","phosphate","."),4357507). assertion_content_comment('tOboGo_PhosphatidylcholineSynthaseActivity',s("Catalysis","of","the","reaction",":","CDP-diacylglycerol","+","choline","=","1",",","2-diacyl-sn-glycero-3-phosphocholine","+","CMP","+","H","(","+",")"),4269308). assertion_content_comment('tOboGo_PhosphatidylcholineTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","phosphatidylcholine","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Phosphatidylcholine","refers","to","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","choline","."),4254964). assertion_content_comment('tOboGo_PhosphatidylethanolamineBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylethanolamine",",","any","of","a","class","of","glycerophospholipids","in","which","a","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","ethanolamine","."),4253569). assertion_content_comment('tOboGo_PhosphatidylethanolamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidylethanolamine",",","any","of","a","class","of","glycerophospholipids","in","which","a","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","ethanolamine","."),4230407). assertion_content_comment('tOboGo_PhosphatidylethanolamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphatidylethanolamine",",","any","of","a","class","of","glycerophospholipids","in","which","a","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","ethanolamine","."),4350005). assertion_content_comment('tOboGo_PhosphatidylethanolamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphatidylethanolamine",",","any","of","a","class","of","glycerophospholipids","in","which","a","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","ethanolamine",".","It","is","a","major","structural","phospholipid","in","mammalian","systems",".","It","tends","to","be","more","abundant","than","phosphatidylcholine","in","the","internal","membranes","of","the","cell","and","is","an","abundant","component","of","prokaryotic","membranes","."),4174152). assertion_content_comment('tOboGo_PhosphatidylglycerolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidylglycerols",",","any","of","a","class","of","phospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","glycerol","."),4230501). assertion_content_comment('tOboGo_PhosphatidylglycerolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphatidylglycerols",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","glycerol","."),4357579). assertion_content_comment('tOboGo_PhosphatidylglycerolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphatidylglycerols",",","any","of","a","class","of","phospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","glycerol",".","They","are","important","constituents","of","cell","membranes","."),4230497). assertion_content_comment('tOboGo_PhosphatidylglycerolPhospholipaseCActivity',s("Catalysis","of","the","reaction",":","a","phosphatidylglycerol","+","H2O","=","1",",","2-diacylglycerol","+","glycerol","3-phosphate","."),4357601). assertion_content_comment('tOboGo_PhosphatidylglycerophosphataseActivity',s("Catalysis","of","the","reaction",":","phosphatidylglycerophosphate","+","H2O","=","phosphatidylglycerol","+","phosphate","."),4247745). assertion_content_comment('tOboGo_PhosphatidylinositolBinding',s("Interacting","selectively","and","non-covalently","with","any","inositol-containing","glycerophospholipid",",","i.e",".","phosphatidylinositol","(","PtdIns",")","and","its","phosphorylated","derivatives","."),4174338). assertion_content_comment('tOboGo_PhosphatidylinositolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidylinositol",",","any","glycophospholipid","with","its","sn-glycerol","3-phosphate","residue","is","esterified","to","the","1-hydroxyl","group","of","1D-myo-inositol","."),4030242). assertion_content_comment('tOboGo_PhosphatidylinositolBisphosphatePhosphataseActivity',s("Catalysis","of","the","removal","of","one","of","the","two","phosphate","groups","of","a","phosphatidylinositol","bisphosphate","."),4191194). assertion_content_comment('tOboGo_PhosphatidylinositolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphatidylinositol",",","any","glycophospholipid","with","its","sn-glycerol","3-phosphate","residue","is","esterified","to","the","1-hydroxyl","group","of","1D-myo-inositol","."),4318936). assertion_content_comment('tOboGo_PhosphatidylinositolDeacylaseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","+","H","(","2",")","O","=","1-acyl-sn-glycero-3-phospho-D-myo-inositol","+","a","carboxylate","+","H","(","+",")"),4263152). assertion_content_comment('tOboGo_PhosphatidylinositolDephosphorylation',s("The","process","of","removing","one","or","more","phosphate","groups","from","a","phosphatidylinositol","."),4115756). assertion_content_comment('tOboGo_PhosphatidylinositolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphatidylinositol",",","any","glycophospholipid","in","which","a","sn-glycerol","3-phosphate","residue","is","esterified","to","the","1-hydroxyl","group","of","1D-myo-inositol","."),4030235). assertion_content_comment('tOboGo_PhosphatidylinositolPhosphateKinaseActivity',s("Catalysis","of","the","phosphorylation","of","phosphatidylinositol","phosphate","to","produce","phosphatidylinositol","bisphosphate","."),4206520). assertion_content_comment('tOboGo_PhosphatidylinositolPhospholipaseCActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","4",",","5-bisphosphate","+","H","(","2",")","O","=","1",",","2-diacylglycerol","+","1D-myo-inositol","1",",","4",",","5-trisphosphate","+","H","(","+",")"),4206481). assertion_content_comment('tOboGo_PhosphatidylinositolPhosphorylation',s("The","process","of","introducing","one","or","more","phosphate","groups","into","a","phosphatidylinositol","."),4358190). assertion_content_comment('tOboGo_PhosphatidylinositolTransporterActivity',s("Enables","the","directed","movement","of","phosphatidylinositol","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Phosphatidylinositol","refers","to","any","glycophospholipids","with","its","sn-glycerol","3-phosphate","residue","is","esterified","to","the","1-hydroxyl","group","of","1D-myo-inositol","."),4254954). assertion_content_comment('tOboGo_PhosphatidylinositolTrisphosphatePhosphataseActivity',s("Catalysis","of","the","removal","of","one","of","the","three","phosphate","groups","of","a","phosphatidylinositol","trisphosphate","."),4304262). assertion_content_comment('tOboGo_PhosphatidylserineBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylserine",",","a","class","of","glycophospholipids","in","which","a","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","L-serine","."),4383398). assertion_content_comment('tOboGo_PhosphatidylserineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidylserines",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","L-serine","."),4230567). assertion_content_comment('tOboGo_PhosphatidylserineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphatidylserines",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","L-serine","."),4230711). assertion_content_comment('tOboGo_PhosphatidylserineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","phosphatidyl-L-serine","=","CO","(","2",")","+","phosphatidylethanolamine","."),4203798). assertion_content_comment('tOboGo_PhosphatidylserineExposureOnApoptoticCellSurface',s("A","phospholipid","scrambling","process","that","results","in","the","appearance","of","phosphatidylserine","on","the","outer","leaflet","of","the","plasma","membrane","of","an","apoptotic","cell",",","which","acts","as","an","\"","eat-me","\"","signal","for","engulfing","cells",".","Phosphatidylserine","is","exposed","on","the","apoptotic","cell","surface","by","a","phospholipid","scramblase","activity","."),4132698). assertion_content_comment('tOboGo_PhosphatidylserineExposureOnBloodPlatelet',s("A","phospholipid","scrambling","process","that","results","in","the","appearance","of","phosphatidylserine","on","the","surface","of","activated","blood","platelets",",","and","triggers","the","clotting","system","."),4074360). assertion_content_comment('tOboGo_PhosphatidylserineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphatidylserines",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","L-serine",".","They","are","important","constituents","of","cell","membranes","."),4230563). assertion_content_comment('tOboGo_PhosphatidyltransferaseActivity',s("Catalysis","of","the","reaction","involving","the","transfer","of","a","phosphatidate","(","otherwise","known","as","diacylglycerol","3-phosphosphate",")","group","."),4250636). assertion_content_comment('tOboGo_PhosphoacetylglucosamineMutaseActivity',s("Catalysis","of","the","reaction",":","N-acetyl-alpha-D-glucosamine","1-phosphate","=","N-acetyl-D-glucosamine","6-phosphate","."),4203811). assertion_content_comment('tOboGo_PhosphoadenylylsulfataseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","H2O","=","adenosine","3","'",",","5","'","-bisphosphate","+","sulfate","."),4263173). assertion_content_comment('tOboGo_PhosphoamidaseActivity',s("Catalysis","of","the","reaction",":","N-phosphocreatine","+","H","(","2",")","O","=","creatine","+","phosphate","."),4263125). assertion_content_comment('tOboGo_PhosphoanandamideDephosphorylation',s("The","process","of","removing","one","or","more","phosphate","groups","from","a","phosphorylated","anandamide","."),4379974). assertion_content_comment('tOboGo_PhosphoarginineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphoarginine",",","a","phosphorylated","derivative","of","the","amino","acid","arginine","."),4349576). assertion_content_comment('tOboGo_PhosphoarginineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphoarginine",",","a","phosphorylated","derivative","of","the","amino","acid","arginine","."),4349679). assertion_content_comment('tOboGo_PhosphoarginineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphoarginine",",","a","phosphagen","of","L-arginine","with","phosphoric","acid","containing","the","phosphoamide","bond",".","It","is","a","source","of","energy","in","the","contraction","of","muscle","in","invertebrates",",","corresponding","to","phosphocreatine","in","the","muscles","of","vertebrates","."),4230220). assertion_content_comment('tOboGo_PhosphocreatineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphocreatine",",","a","phosphagen","of","creatine","which","is","synthesized","and","broken","down","by","creatine","phosphokinase","."),4349703). assertion_content_comment('tOboGo_PhosphocreatineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphocreatine",",","a","phosphagen","of","creatine","which","is","synthesized","and","broken","down","by","creatine","phosphokinase","."),4349633). assertion_content_comment('tOboGo_PhosphocreatineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphocreatine",",","a","phosphagen","of","creatine","present","in","high","concentration","in","striated","muscle","which","is","synthesized","and","broken","down","by","creatine","phosphokinase","to","buffer","ATP","concentration",".","It","acts","as","an","immediate","energy","reserve","for","muscle","."),4230209). assertion_content_comment('tOboGo_PhosphodiesteraseIActivity',s("Catalysis","of","the","sequential","hydrolytic","removal","of","5","'","-nucleotides","from","the","3","'","-hydroxy","termini","of","3","'","-hydroxy-terminated","oligonucleotides","."),4204960). assertion_content_comment('tOboGo_PhosphoenolpyruvateCarboxykinaseActivity',s("Catalysis","of","the","reaction",":","source","of","phosphate","+","oxaloacetate","=","phosphoenolpyruvate","+","CO2","+","other","reaction","products","."),4203827). assertion_content_comment('tOboGo_PhosphoenolpyruvateCarboxykinaseATPActivity',s("Catalysis","of","the","reaction",":","ATP","+","oxaloacetate","=","ADP","+","CO","(","2",")","+","H","(","+",")","+","phosphoenolpyruvate","."),4203840). assertion_content_comment('tOboGo_PhosphoenolpyruvateCarboxykinaseDiphosphateActivity',s("Catalysis","of","the","reaction",":","diphosphate","+","oxaloacetate","=","CO","(","2",")","+","phosphate","+","phosphoenolpyruvate","."),4307694). assertion_content_comment('tOboGo_PhosphoenolpyruvateCarboxykinaseGTPActivity',s("Catalysis","of","the","reaction",":","GTP","+","oxaloacetate","=","GDP","+","phosphoenolpyruvate","+","CO2","."),4203859). assertion_content_comment('tOboGo_PhosphoenolpyruvateCarboxylaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","oxaloacetate","+","phosphate","=","CO","(","2",")","+","H","(","2",")","O","+","phosphoenolpyruvate","."),4247828). assertion_content_comment('tOboGo_PhosphoenolpyruvateMutaseActivity',s("Catalysis","of","the","reaction",":","phosphoenolpyruvate","=","3-phosphonopyruvate","."),4263137). assertion_content_comment('tOboGo_PhosphoenolpyruvatePhosphataseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","phosphoenolpyruvate","=","phosphate","+","pyruvate","."),4263040). assertion_content_comment('tOboGo_Phosphoenolpyruvate_PhosphateAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","phosphoenolpyruvate","(","out",")","+","phosphate","(","in",")","=","phosphoenolpyruvate","(","in",")","+","phosphate","(","out",")"),4297335). assertion_content_comment('tOboGo_PhosphoenolpyruvateTransport',s("The","directed","movement","of","phosphoenolpyruvate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290691). assertion_content_comment('tOboGo_PhosphoethanolaminePhosphocholinePhosphataseActivity',s("Catalysis","of","the","reactions",":","O-phosphoethanolamine","+","H2O","=","ethanolamine","+","phosphate",",","and","phosphocholine","+","H2O","=","choline","+","phosphate","."),4343442). assertion_content_comment('tOboGo_PhosphofructokinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","fructose","substrate","molecule","."),4189639). assertion_content_comment('tOboGo_PhosphoglucanWaterDikinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","[","phospho-alpha-glucan","]","+","H2O","=","AMP","+","O-phospho-","[","phospho-alpha-glucan","]","+","phosphate","."),4280021). assertion_content_comment('tOboGo_PhosphoglucokinaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-glucose","1-phosphate","+","ATP","=","alpha-D-glucose","1",",","6-bisphosphate","+","ADP","+","2","H","(","+",")"),4262903). assertion_content_comment('tOboGo_PhosphoglucomutaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-glucose","1-phosphate","=","alpha-D-glucose","6-phosphate","."),4203877). assertion_content_comment('tOboGo_PhosphogluconateDehydrataseActivity',s("Catalysis","of","the","reaction",":","6-phospho-D-gluconate","=","2-dehydro-3-deoxy-6-phospho-D-gluconate","+","H","(","2",")","O","."),4206950). assertion_content_comment('tOboGo_PhosphogluconateDehydrogenaseDecarboxylatingActivity',s("Catalysis","of","the","reaction",":","6-phospho-D-gluconate","+","NADP","+","=","D-ribulose","5-phosphate","+","CO2","+","NADPH","+","H","+"),4203103). assertion_content_comment('tOboGo_PhosphoglucosamineMutaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-glucosamine","1-phosphate","=","D-glucosamine","6-phosphate","."),4247798). assertion_content_comment('tOboGo_PhosphoglycerateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","3-phosphoglycerate","+","NAD","+","=","3-phosphohydroxypyruvate","+","NADH","+","H","+"),4203120). assertion_content_comment('tOboGo_PhosphoglycerateKinaseActivity',s("Catalysis","of","the","reaction",":","3-phospho-D-glycerate","+","ATP","=","3-phospho-D-glyceroyl","phosphate","+","ADP","+","H","(","+",")"),4203149). assertion_content_comment('tOboGo_PhosphoglycerateKinaseGTPActivity',s("Catalysis","of","the","reaction",":","3-phospho-D-glycerate","+","GTP","=","3-phospho-D-glyceroyl","phosphate","+","GDP","+","H","(","+",")"),4262917). assertion_content_comment('tOboGo_PhosphoglycerateMutaseActivity',s("Catalysis","of","the","reaction",":","2-phospho-D-glycerate","=","3-phospho-D-glycerate","."),4203187). assertion_content_comment('tOboGo_PhosphoglyceratePhosphataseActivity',s("Catalysis","of","the","reaction",":","2-phospho-D-glycerate","+","H","(","2",")","O","=","D-glycerate","+","phosphate","."),4262927). assertion_content_comment('tOboGo_PhosphoglycerateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","phosphoglycerates","from","one","side","of","the","membrane","to","the","other",".","Phosphoglycerates","are","important","intermediates","in","glycolysis","and","3-phosphoglycerate","is","a","precursor","in","serine","biosynthesis","."),4297349). assertion_content_comment('tOboGo_PhosphoglycerateTransport',s("The","directed","movement","of","phosphoglycerate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290702). assertion_content_comment('tOboGo_PhosphoglycerolGeranylgeranyltransferaseActivity',s("Catalysis","of","the","reaction",":","sn-glycerol","1-phosphate","+","all-trans-geranylgeranyl","diphosphate","=","sn-3-O-","(","geranylgeranyl",")","glycerol","1-phosphate","+","diphosphate","."),4367626). assertion_content_comment('tOboGo_PhosphoglycolatePhosphataseActivity',s("Catalysis","of","the","reaction",":","2-phosphoglycolate","+","H","(","2",")","O","=","glycolate","+","phosphate","."),4247783). assertion_content_comment('tOboGo_PhosphohistidinePhosphataseActivity',s("Catalysis","of","the","reaction",":","phosphohistidine","+","H2O","=","histidine","+","phosphate","."),4247845). assertion_content_comment('tOboGo_PhosphoketolaseActivity',s("Catalysis","of","the","reaction",":","D-xylulose","5-phosphate","+","phosphate","=","acetyl","phosphate","+","D-glyceraldehyde","3-phosphate","+","H2O","."),4262940). assertion_content_comment('tOboGo_PhospholactateGuanylyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-phospho-","(","S",")","-lactate","+","GTP","=","lactyl-2-diphospho-5","'","-guanosine","+","diphosphate","."),4327509). assertion_content_comment('tOboGo_PhospholipaseA1Activity',s("Catalysis","of","the","reaction",":","phosphatidylcholine","+","H2O","=","2-acylglycerophosphocholine","+","a","carboxylate","."),4247867). assertion_content_comment('tOboGo_PhospholipaseA2ActivatorActivity',s("Increases","the","activity","of","the","enzyme","phospholipase","A2","."),4302705). assertion_content_comment('tOboGo_PhospholipaseA2Activity',s("Catalysis","of","the","reaction",":","phosphatidylcholine","+","H2O","=","1-acylglycerophosphocholine","+","a","carboxylate","."),4202984). assertion_content_comment('tOboGo_PhospholipaseA2InhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","the","enzyme","phospholipase","A2","."),4233774). assertion_content_comment('tOboGo_PhospholipaseActivatorActivity',s("Increases","the","activity","of","a","phospholipase",",","an","enzyme","that","catalyzes","of","the","hydrolysis","of","a","glycerophospholipid","."),4302703). assertion_content_comment('tOboGo_PhospholipaseActivity',s("Catalysis","of","the","hydrolysis","of","a","glycerophospholipid","."),4174185). assertion_content_comment('tOboGo_PhospholipaseBinding',s("Interacting","selectively","and","non-covalently","with","any","phospholipase",",","enzymes","that","catalyze","of","the","hydrolysis","of","a","glycerophospholipid","."),4318348). assertion_content_comment('tOboGo_PhospholipaseCActivity',s("Catalysis","of","the","reaction",":","a","phospholipid","+","H2O","=","1",",","2-diacylglycerol","+","a","phosphatidate","."),4202954). assertion_content_comment('tOboGo_PhospholipaseDActivity',s("Catalysis","of","the","reaction",":","a","phosphatidylcholine","+","H2O","=","choline","+","a","phosphatidate","."),4202871). assertion_content_comment('tOboGo_PhospholipaseDInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","phospholipase","D",",","an","enzyme","that","catalyzes","the","reaction",":","a","phosphatidylcholine","+","H2O","=","choline","+","a","phosphatidate","."),4156720). assertion_content_comment('tOboGo_PhospholipaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","phospholipase",",","an","enzyme","that","catalyzes","of","the","hydrolysis","of","a","phospholipid","."),4156718). assertion_content_comment('tOboGo_PhospholipidBinding',s("Interacting","selectively","and","non-covalently","with","phospholipids",",","a","class","of","lipids","containing","phosphoric","acid","as","a","mono-","or","diester","."),4172896). assertion_content_comment('tOboGo_PhospholipidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phospholipids",",","any","lipid","containing","phosphoric","acid","as","a","mono-","or","diester","."),4009944). assertion_content_comment('tOboGo_PhospholipidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phospholipids",",","any","lipid","containing","phosphoric","acid","as","a","mono-","or","diester","."),4037923). assertion_content_comment('tOboGo_PhospholipidDephosphorylation',s("The","process","of","removing","one","or","more","phosphate","groups","from","a","phosphorylated","lipid",",","any","member","of","a","group","of","substances","soluble","in","lipid","solvents","but","only","sparingly","soluble","in","aqueous","solvents","."),4115754). assertion_content_comment('tOboGo_Phospholipid_DiacylglycerolAcyltransferaseActivity',s("Catalysis","of","the","reaction",":","phospholipid","+","1",",","2-diacylglycerol","=","lysophospholipid","+","triacylglycerol","."),4348095). assertion_content_comment('tOboGo_PhospholipidEfflux',s("The","directed","movement","of","a","phospholipid","out","of","a","cell","or","organelle","."),4341834). assertion_content_comment('tOboGo_PhospholipidHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","phospholipid","within","an","organism","or","cell","."),4222151). assertion_content_comment('tOboGo_PhospholipidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phospholipids",",","any","lipid","containing","phosphoric","acid","as","a","mono-","or","diester","."),4009923). assertion_content_comment('tOboGo_PhospholipidScramblaseActivity',s("Catalysis","of","the","movement","of","phospholipids","from","one","membrane","bilayer","leaflet","to","the","other",",","by","an","ATP-independent","mechanism","."),4267480). assertion_content_comment('tOboGo_PhospholipidScrambling',s("The","movement","of","a","population","of","phospholipid","molecules","from","one","leaflet","of","the","plasma","membrane","bilayer","to","the","opposite","leaflet",",","resulting","in","loss","of","lipid","asymmetry","and","surface","exposure","of","phosphatidylserine","(","PS",")","and","phosphatidylethanolamine","(","PE",")"),4074356). assertion_content_comment('tOboGo_PhospholipidTransferToMembrane',s("The","transfer","of","a","phospholipid","from","its","site","of","synthesis","to","the","plasma","membrane","."),4013782). assertion_content_comment('tOboGo_PhospholipidTranslocation',s("The","movement","of","a","phospholipid","molecule","from","one","leaflet","of","a","membrane","bilayer","to","the","opposite","leaflet","."),4135378). assertion_content_comment('tOboGo_PhospholipidTransporterActivity',s("Enables","the","directed","movement","of","phospholipids","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Phospholipids","are","a","class","of","lipids","containing","phosphoric","acid","as","a","mono-","or","diester","."),4183713). assertion_content_comment('tOboGo_PhospholipidTransport',s("The","directed","movement","of","phospholipids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Phospholipids","are","any","lipids","containing","phosphoric","acid","as","a","mono-","or","diester","."),4013779). assertion_content_comment('tOboGo_PhosphomannanMannosephosphotransferaseActivity',s("Catalysis","of","the","reaction",":","phosphomannan","(","n",")","+","GDP-mannose","=","phosphomannan","(","n","+","1",")","+","GMP","."),4367846). assertion_content_comment('tOboGo_PhosphomannomutaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-mannose","1-phosphate","=","D-mannose","6-phosphate","."),4203891). assertion_content_comment('tOboGo_PhosphomethylpyrimidineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","4-amino-2-methyl-5-phosphomethylpyrimidine","=","ADP","+","4-amino-2-methyl-5-diphosphomethylpyrimidine","."),4247879). assertion_content_comment('tOboGo_PhosphomevalonateKinaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-5-phosphomevalonate","+","ATP","=","(","R",")","-5-diphosphomevalonate","+","ADP","+","H","(","+",")"),4202854). assertion_content_comment('tOboGo_PhosphonateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphonates",",","any","organic","compound","containing","one","or","more","C-PO","(","OH",")","2","or","C-PO","(","OR",")","2","(","with","R","=","alkyl",",","aryl",")","groups",".","Synthesis","of","phosphonic","acid","itself",",","an","inorganic","compound","without","the","biochemically","relevant","C-P","bond",",","is","not","included","."),4337004). assertion_content_comment('tOboGo_PhosphonateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphonates",",","any","organic","compound","containing","one","or","more","C-PO","(","OH",")","2","or","C-PO","(","OR",")","2","(","with","R","=","alkyl",",","aryl",")","groups",".","Catabolism","of","phosphonic","acid","itself",",","an","inorganic","compound","without","the","biochemically","relevant","C-P","bond",",","is","not","included","."),4244061). assertion_content_comment('tOboGo_PhosphonateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","NAD","(","+",")","+","phosphonate","=","2","H","(","+",")","+","NADH","+","phosphate","."),4278315). assertion_content_comment('tOboGo_PhosphonateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","of","phosphonates",",","any","organic","compound","containing","one","or","more","C-PO","(","OH",")","2","or","C-PO","(","OR",")","2","(","with","R","=","alkyl",",","aryl",")","groups",".","Metabolism","of","phosphonic","acid","itself",",","an","inorganic","compound","without","the","biochemically","relevant","C-P","bond",",","is","not","included","."),4244041). assertion_content_comment('tOboGo_PhosphonateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","phosphonate","from","one","side","of","a","membrane","to","the","other",".","A","phosphonate","is","any","salt",",","anion",",","or","ester","of","phosphonic","acid","(","HPO","(","OH",")","2",")"),4289836). assertion_content_comment('tOboGo_PhosphonateTransport',s("The","directed","movement","of","phosphonates","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","A","phosphonate","is","any","salt",",","anion",",","or","ester","of","phosphonic","acid","(","HPO","(","OH",")","2",")"),4290584). assertion_content_comment('tOboGo_PhosphonoacetaldehydeHydrolaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","phosphonoacetaldehyde","=","acetaldehyde","+","H","(","+",")","+","phosphate","."),4262963). assertion_content_comment('tOboGo_PhosphonoacetateHydrolaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","phosphonoacetate","=","acetate","+","H","(","+",")","+","phosphate","."),4370388). assertion_content_comment('tOboGo_PhosphonoacetateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phosphonoacetate",",","C2H4PO5",",","a","substance","composed","of","an","acetate","and","a","phosphonic","acid","residue","."),4244111). assertion_content_comment('tOboGo_PhosphonopyruvateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","3-phosphonopyruvate","+","2","H","(","+",")","=","CO","(","2",")","+","phosphonoacetaldehyde","."),4344962). assertion_content_comment('tOboGo_PhosphonopyruvateHydrolaseActivity',s("Catalysis","of","the","reaction",":","3-phosphonopyruvate","+","H","(","2",")","O","=","phosphate","+","pyruvate","."),4345024). assertion_content_comment('tOboGo_PhosphopantetheineBinding',s("Interacting","selectively","with","phosphopantetheine",",","the","vitamin","pantetheine","4","'","-","(","dihydrogen","phosphate",")"),4319078). assertion_content_comment('tOboGo_PhosphopantothenoylcysteineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","N-","[","(","R",")","-4-phosphonatopantothenoyl","]","-L-cysteinate","+","H","(","+",")","=","CO","(","2",")","+","pantetheine","4","'","-phosphate","."),4202824). assertion_content_comment('tOboGo_PhosphopantothenoylcysteineDecarboxylaseComplex',s("A","protein","complex","that","catalyzes","decarboxylation","of","4","'","-phosphopantothenoylcysteine","to","yield","4","'","-phosphopantetheine",";","this","is","the","third","step","in","the","biosynthesis","of","Coenzyme","A",".","The","complex","is","homotrimeric","in","many","eukaryotes",",","but","is","a","heterotrimer","in","Saccharomyces","."),4172239). assertion_content_comment('tOboGo_PhosphopentomutaseActivity',s("Catalysis","of","the","reaction",":","D-ribose","1-phosphate","=","D-ribose","5-phosphate","."),4247911). assertion_content_comment('tOboGo_PhosphopolyprenolGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","polyprenyl","phosphate","+","UDP-D-glucose","=","polyprenylphosphate-glucose","+","UDP","."),4367512). assertion_content_comment('tOboGo_PhosphoproteinBinding',s("Interacting","selectively","and","non-covalently","with","a","phosphorylated","protein","."),4274834). assertion_content_comment('tOboGo_PhosphoproteinPhosphataseActivity',s("Catalysis","of","the","reaction",":","a","phosphoprotein","+","H2O","=","a","protein","+","phosphate",".","Together","with","protein","kinases",",","these","enzymes","control","the","state","of","phosphorylation","of","cell","proteins","and","thereby","provide","an","important","mechanism","for","regulating","cellular","activity","."),4200881). assertion_content_comment('tOboGo_PhosphopyruvateHydrataseActivity',s("Catalysis","of","the","reaction",":","2-phospho-D-glycerate","=","phosphoenolpyruvate","+","H2O","."),4202931). assertion_content_comment('tOboGo_PhosphopyruvateHydrataseComplex',s("A","multimeric","enzyme","complex",",","usually","a","dimer","or","an","octamer",",","that","catalyzes","the","conversion","of","2-phospho-D-glycerate","to","phosphoenolpyruvate","and","water","."),4345334). assertion_content_comment('tOboGo_PhosphoribokinaseActivity',s("Catalysis","of","the","reaction",":","D-ribose","5-phosphate","+","ATP","=","D-ribose","1",",","5-diphosphate","+","ADP","+","2","H","(","+",")"),4262977). assertion_content_comment('tOboGo_PhosphoribosylaminoimidazolecarboxamideFormyltransferaseActivity',s("Catalysis","of","the","reaction",":","10-formyltetrahydrofolate","+","5","'","-phosphoribosyl-5-amino-4-imidazolecarboxamide","=","tetrahydrofolate","+","5","'","-phosphoribosyl-5-formamido-4-imidazolecarboxamide","."),4203532). assertion_content_comment('tOboGo_PhosphoribosylaminoimidazoleCarboxylaseActivity',s("Catalysis","of","the","reaction",":","5-amino-1-","(","5-phospho-D-ribosyl",")","imidazole-4-carboxylate","+","2","H","(","+",")","=","5-amino-1-","(","5-phospho-D-ribosyl",")","imidazole","+","CO","(","2",")"),4203567). assertion_content_comment('tOboGo_PhosphoribosylaminoimidazoleCarboxylaseComplex',s("A","protein","complex","that","possesses","phosphoribosylaminoimidazole","carboxylase","activity","."),4259793). assertion_content_comment('tOboGo_PhosphoribosylaminoimidazolesuccinocarboxamideSynthaseActivity',s("Catalysis","of","the","reaction",":","5-amino-1-","(","5-phospho-D-ribosyl",")","imidazole-4-carboxylate","+","L-aspartate","+","ATP","=","(","2S",")","-2-","[","5-amino-1-","(","5-phospho-beta-D-ribosyl",")","imidazole-4-carboxamido","]","succinate","+","ADP","+","2","H","(","+",")","+","phosphate","."),4203585). assertion_content_comment('tOboGo_PhosphoribosylanthranilateIsomeraseActivity',s("Catalysis","of","the","reaction",":","N-","(","5-phospho-beta-D-ribosyl",")","anthranilate","=","1-","(","2-carboxyphenylamino",")","-1-deoxy-D-ribulose","5-phosphate","."),4203551). assertion_content_comment('tOboGo_PhosphoribosylformylglycinamidineSynthaseActivity',s("Catalysis","of","the","reaction",":","N","(","2",")","-formyl-N","(","1",")","-","(","5-phospho-D-ribosyl",")","glycinamide","+","L-glutamine","+","ATP","+","H","(","2",")","O","=","2-","(","formamido",")","-N","(","1",")","-","(","5-phospho-D-ribosyl",")","acetamidine","+","L-glutamate","+","ADP","+","2","H","(","+",")","+","phosphate","."),4203464). assertion_content_comment('tOboGo_PhosphoribosylglycinamideFormyltransferase2Activity',s("Catalysis","of","the","reaction",":","formate","+","ATP","+","5","'","-phospho-ribosylglycinamide","=","5","'","-phosphoribosyl-N-formylglycinamide","+","ADP","+","diphosphate","."),4327519). assertion_content_comment('tOboGo_PhosphoribosylglycinamideFormyltransferaseActivity',s("Catalysis","of","the","reaction",":","10-formyltetrahydrofolate","+","N1-","(","5-phospho-D-ribosyl",")","glycinamide","=","tetrahydrofolate","+","N2-formyl-N1-","(","5-phospho-D-ribosyl",")","glycinamide","."),4203513). assertion_content_comment('tOboGo_PhosphoribulokinaseActivity',s("Catalysis","of","the","reaction",":","D-ribulose","5-phosphate","+","ATP","=","D-ribulose","1",",","5-bisphosphate","+","ADP","+","2","H","(","+",")"),4247892). assertion_content_comment('tOboGo_PhosphoricDiesterHydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","a","phosphodiester","to","give","a","phosphomonoester","and","a","free","hydroxyl","group","."),4164396). assertion_content_comment('tOboGo_PhosphoricEsterHydrolaseActivity',s("Catalysis","of","the","reaction",":","RPO-R","'","+","H2O","=","RPOOH","+","R","'","H",".","This","reaction","is","the","hydrolysis","of","any","phosphoric","ester","bond",",","any","ester","formed","from","orthophosphoric","acid",",","O","=","P","(","OH",")","3","."),4164394). assertion_content_comment('tOboGo_PhosphoricTriesterHydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","a","phosphoric","triester","."),4301481). assertion_content_comment('tOboGo_PhosphorusMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","nonmetallic","element","phosphorus","or","compounds","that","contain","phosphorus",",","usually","in","the","form","of","a","phosphate","group","(","PO4",")"),3972298). assertion_content_comment('tOboGo_PhosphorusUtilization',s("A","series","of","processes","that","forms","an","integrated","mechanism","by","which","a","cell","or","an","organism","detects","the","depletion","of","primary","phosphorus","source","and","then","activates","genes","to","scavenge","the","last","traces","of","the","primary","phosphorus","source","and","to","transport","and","metabolize","alternative","phosphorus","sources",".","The","utilization","process","begins","when","the","cell","or","organism","detects","phosphorus","levels",",","includes","the","phosphorus-containing","substances",",","and","ends","when","phosphorus","is","incorporated","into","the","cell","or","organism","'","s","metabolism","."),4014595). assertion_content_comment('tOboGo_PhosphorylaseActivity',s("Catalysis","of","the","reaction",":","1",",","4-alpha-D-glucosyl","(","n",")","+","phosphate","=","1",",","4-alpha-D-glucosyl","(","n-1",")","+","alpha-D-glucose","1-phosphate",".","The","name","should","be","qualified","in","each","instance","by","adding","the","name","of","the","natural","substrate",",","e.g",".","maltodextrin","phosphorylase",",","starch","phosphorylase",",","glycogen","phosphorylase","."),4181941). assertion_content_comment('tOboGo_PhosphorylaseKinaseActivity',s("Catalysis","of","the","reaction",":","4","ATP","+","2","phosphorylase","b","=","4","ADP","+","phosphorylase","a","."),4202762). assertion_content_comment('tOboGo_PhosphorylaseKinaseComplex',s("An","enzyme","complex","that","catalyzes","the","phosphorylation","of","phosphorylase","b","to","form","phosphorylase","a","."),4221039). assertion_content_comment('tOboGo_PhosphorylaseKinaseRegulatorActivity',s("Modulation","of","the","activity","of","the","enzyme","phosphorylase","kinase","."),4253167). assertion_content_comment('tOboGo_PhosphorylasePhosphataseActivity',s("Catalysis","of","the","reaction",":","[","phosphorylase","a","]","+","4","H2O","=","2","[","phosphorylase","b","]","+","4","phosphate","."),4262988). assertion_content_comment('tOboGo_PhosphorylatedCarbohydrateDephosphorylation',s("The","process","of","removing","a","phosphate","group","from","a","phosphorylated","carbohydrate",",","any","organic","compound","based","on","the","general","formula","Cx","(","H2O",")","y","with","a","phosphate","group","attached","to","it","."),4340773). assertion_content_comment('tOboGo_Phosphorylation',s("The","process","of","introducing","a","phosphate","group","into","a","molecule",",","usually","with","the","formation","of","a","phosphoric","ester",",","a","phosphoric","anhydride","or","a","phosphoric","amide","."),3972304). assertion_content_comment('tOboGo_PhosphoserineBinding',s("Interacting","selectively","and","non-covalently","with","a","phosphorylated","serine","residue","within","a","protein","."),4274851). assertion_content_comment('tOboGo_Phosphoserine_HomoserinePhosphotransferaseActivity',s("Catalysis","of","the","transfer","of","a","phosphoryl","group","from","phosphoserine","to","homoserine","to","form","phosphohomoserine","."),4328921). assertion_content_comment('tOboGo_PhosphoserinePhosphataseActivity',s("Catalysis","of","the","reaction",":","L","(","or","D",")","-O-phosphoserine","+","H2O","=","L","(","or","D",")","-serine","+","phosphate","."),4203453). assertion_content_comment('tOboGo_PhosphoserinePhosphothreonineBinding',s("OBSOLETE",".","Interacting","selectively","with","a","phosphorylated","serine","or","threonine","residue","within","a","protein","."),4298530). assertion_content_comment('tOboGo_PhosphosulfolactateSynthaseActivity',s("Catalysis","of","the","reaction",":","(","2R",")","-O-phospho-3-sulfolactate","=","phosphoenolpyruvate","+","sulfite","."),4327579). assertion_content_comment('tOboGo_PhosphothreonineBinding',s("Interacting","selectively","and","non-covalently","with","a","phosphorylated","threonine","residue","within","a","protein","."),4274840). assertion_content_comment('tOboGo_PhosphothreonineLyaseActivity',s("Catalysis","of","the","removal","of","the","phosphate","group","from","phosphothreonine","by","cleavage","of","the","C-OP","bond","with","the","concomitant","abstraction","of","the","alpha","proton",",","generating","a","double","bond-containing","product","."),4352434). assertion_content_comment('tOboGo_PhosphotransferaseActivityAlcoholGroupAsAcceptor',s("Catalysis","of","the","transfer","of","a","phosphorus-containing","group","from","one","compound","(","donor",")","to","an","alcohol","group","(","acceptor",")"),4157290). assertion_content_comment('tOboGo_PhosphotransferaseActivityCarboxylGroupAsAcceptor',s("Catalysis","of","the","transfer","of","a","phosphorus-containing","group","from","one","compound","(","donor",")","to","a","carboxyl","group","(","acceptor",")"),4186481). assertion_content_comment('tOboGo_PhosphotransferaseActivityForOtherSubstitutedPhosphateGroups',s("Catalysis","of","the","transfer","of","a","substituted","phosphate","group",",","other","than","diphosphate","or","nucleotidyl","residues",",","from","one","compound","(","donor",")","to","a","another","(","acceptor",")"),4183453). assertion_content_comment('tOboGo_PhosphotransferaseActivityNitrogenousGroupAsAcceptor',s("Catalysis","of","the","transfer","of","a","phosphorus-containing","group","from","one","compound","(","donor",")","to","a","nitrogenous","group","(","acceptor",")"),4202303). assertion_content_comment('tOboGo_PhosphotransferaseActivityPairedAcceptors',s("Catalysis","of","the","transfer","of","two","phosphate","groups","from","a","donor",",","such","as","ATP",",","to","two","different","acceptors","."),4201479). assertion_content_comment('tOboGo_PhosphotransferaseActivityPhosphateGroupAsAcceptor',s("Catalysis","of","the","transfer","of","a","phosphorus-containing","group","from","one","compound","(","donor",")","to","a","phosphate","group","(","acceptor",")"),4179413). assertion_content_comment('tOboGo_PhosphotyrosineBinding',s("Interacting","selectively","and","non-covalently","with","a","phosphorylated","tyrosine","residue","within","a","protein","."),4383389). assertion_content_comment('tOboGo_Photoinhibition',s("The","mechanism","by","which","high","light","intensity","inhibits","photosynthesis","through","inactivation","of","the","D1","protein","of","photosystem","II","."),4031616). assertion_content_comment('tOboGo_Photomorphogenesis',s("The","control","of","plant","growth",",","development",",","and","differentiation","by","the","duration","and","nature","of","light",",","independent","of","photosynthesis","."),4022626). assertion_content_comment('tOboGo_PhotoperiodismFlowering',s("A","change","from","the","vegetative","to","the","reproductive","phase","as","a","result","of","detection","of",",","or","exposure","to",",","a","period","of","light","or","dark","of","a","given","length",".","The","length","of","the","period","of","light","or","dark","required","to","initiate","the","change","is","set","relative","to","a","particular","duration","known","as","the","'","critical","day","length","'","The","critical","day","length","varies","between","species","."),4106220). assertion_content_comment('tOboGo_Photoperiodism',s("A","change","in","state","or","activity","of","the","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","detection","of",",","or","exposure","to",",","a","period","of","light","or","dark","of","a","given","length",",","measured","relative","to","a","particular","duration","known","as","the","'","critical","day","length","'","The","critical","day","length","varies","between","species","."),4106214). assertion_content_comment('tOboGo_Photoprotection',s("Protection","mechanism","used","by","plants","under","conditions","of","excess","energy","absorption","as","a","consequence","of","the","light","reactions","of","photosynthesis","."),4334538). assertion_content_comment('tOboGo_PhotoreactiveRepair',s("The","repair","of","UV-induced","T-T",",","C-T","and","C-C","dimers","by","directly","reversing","the","damage","to","restore","the","original","pyrimidines","."),4363843). assertion_content_comment('tOboGo_PhotoreceptorActivity',s("The","function","of","absorbing","and","responding","to","incidental","electromagnetic","radiation",",","particularly","visible","light",".","The","response","may","involve","a","change","in","conformation","."),4246980). assertion_content_comment('tOboGo_PhotoreceptorCellAxonGuidance',s("The","chemotaxis","process","that","directs","the","migration","of","a","photoreceptor","cell","axon","growth","cone","to","its","target","in","the","optic","lobe","in","response","to","a","combination","of","attractive","and","repulsive","cues","."),4139814). assertion_content_comment('tOboGo_PhotoreceptorCellDevelopment',s("Development","of","a","photoreceptor",",","a","cell","that","responds","to","incident","electromagnetic","radiation",",","particularly","visible","light","."),4017907). assertion_content_comment('tOboGo_PhotoreceptorCellDifferentiation',s("The","specialization","of","organization","of","a","photoreceptor",",","a","cell","that","responds","to","incident","electromagnetic","radiation",",","particularly","visible","light",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),3984954). assertion_content_comment('tOboGo_PhotoreceptorCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","photoreceptor","cell",".","A","photoreceptor","cell","is","a","cell","that","responds","to","incident","electromagnetic","radiation",".","Different","classes","of","photoreceptor","have","different","spectral","sensitivities","and","express","different","photosensitive","pigments","."),3985252). assertion_content_comment('tOboGo_PhotoreceptorCellFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","photoreceptor","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4077944). assertion_content_comment('tOboGo_PhotoreceptorCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","photoreceptor","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",".","Upon","specification",",","the","cell","fate","can","be","reversed","."),4033504). assertion_content_comment('tOboGo_PhotoreceptorCellMaintenance',s("Any","process","preventing","the","degeneration","of","the","photoreceptor",",","a","specialized","cell","type","that","is","sensitive","to","light","."),4088515). assertion_content_comment('tOboGo_PhotoreceptorCellMorphogenesis',s("The","process","in","which","the","structures","of","a","photoreceptor","cell","are","generated","and","organized",".","This","process","occurs","while","the","initially","relatively","unspecialized","cell","is","acquiring","the","specialized","features","of","a","photoreceptor","cell",",","a","sensory","cell","that","reacts","to","the","presence","of","light",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4019933). assertion_content_comment('tOboGo_PhotoreceptorConnectingCilium',s("A","nonmotile","primary","cilium","that","has","a","9","+","0","microtubule","array","and","forms","the","portion","of","the","axoneme","traversing","the","boundary","between","the","photoreceptor","inner","and","outer","segments","."),4333584). assertion_content_comment('tOboGo_PhotoreceptorInnerSegmentMembrane',s("The","membrane","surrounding","the","outer","segment","of","a","vertebrate","photoreceptor",".","The","photoreceptor","inner","segment","contains","mitochondria",",","ribosomes","and","membranes","where","opsin","molecules","are","assembled","and","passed","to","be","part","of","the","outer","segment","discs","."),4114598). assertion_content_comment('tOboGo_PhotoreceptorInnerSegment',s("The","inner","segment","of","a","vertebrate","photoreceptor","containing","mitochondria",",","ribosomes","and","membranes","where","opsin","molecules","are","assembled","and","passed","to","be","part","of","the","outer","segment","discs","."),4114588). assertion_content_comment('tOboGo_PhotoreceptorOuterSegmentMembrane',s("The","membrane","surrounding","the","outer","segment","of","a","vertebrate","photoreceptor","."),4077654). assertion_content_comment('tOboGo_PhotoreceptorOuterSegment',s("The","outer","segment","of","a","vertebrate","photoreceptor","that","contains","discs","of","photoreceptive","membranes","."),4077632). assertion_content_comment('tOboGo_Photorespiration',s("A","light-dependent","catabolic","process","occurring","concomitantly","with","photosynthesis","in","plants","(","especially","C3","plants",")","whereby","dioxygen","(","O2",")","is","consumed","and","carbon","dioxide","(","CO2",")","is","evolved",".","The","substrate","is","glycolate","formed","in","large","quantities","in","chloroplasts","from","2-phosphoglycolate","generated","from","ribulose","1",",","5-bisphosphate","by","the","action","of","ribulose-bisphosphate","carboxylase",";","the","glycolate","enters","the","peroxisomes","where","it","is","converted","by","glycolate","oxidase","to","glyoxylate","which","undergoes","transamination","to","glycine",".","This","then","passes","into","the","mitochondria","where","it","is","decarboxylated","forming","one","molecule","of","serine","for","every","two","molecules","of","glycine",".","This","pathway","also","exists","in","photosynthetic","bacteria","."),4022139). assertion_content_comment('tOboGo_PhotosynthesisDarkReaction',s("A","complex","cycle","of","enzyme-mediated","reactions","which","catalyzes","the","reduction","of","carbon","dioxide","to","sugar",".","As","well","as","carbon","dioxide","the","cycle","requires","reducing","power","in","the","form","of","reduced","nicotinamide","adenine","dinucleotide","phosphate","(","NADP",")","and","chemical","energy","in","the","form","of","adenosine","triphosphate","(","ATP",")","The","reduced","NADP","(","NADPH",")","and","ATP","are","produced","by","the","'","light","'","reactions","."),4033059). assertion_content_comment('tOboGo_PhotosynthesisLightHarvestingInPhotosystemII',s("After","a","photon","of","light","is","absorbed","by","one","of","the","many","chlorophyll","molecules",",","in","one","of","the","light-harvesting","complexes","of","an","antenna","on","photosystem","II",",","some","of","the","absorbed","energy","is","transferred","to","the","pair","of","chlorophyll","molecules","in","the","reaction","center","."),4262720). assertion_content_comment('tOboGo_PhotosynthesisLightHarvestingInPhotosystemI',s("After","a","photon","of","light","is","absorbed","by","one","of","the","many","chlorophyll","molecules",",","in","one","of","the","light-harvesting","complexes","of","an","antenna","on","photosystem","I",",","some","of","the","absorbed","energy","is","transferred","to","the","pair","of","chlorophyll","molecules","in","the","reaction","center","."),4262729). assertion_content_comment('tOboGo_PhotosynthesisLightHarvesting',s("Absorption","and","transfer","of","the","energy","absorbed","from","light","photons","between","photosystem","reaction","centers","."),4022417). assertion_content_comment('tOboGo_PhotosynthesisLightReaction',s("The","light","reactions","of","photosynthesis",",","which","take","place","in","photosystems","II","and","I",".","Light","energy","is","harvested","and","used","to","power","the","transfer","of","electrons","among","a","series","of","electron","donors","and","acceptors",".","The","final","electron","acceptor","is","NADP","+",",","which","is","reduced","to","NADPH",".","NADPH","generated","from","light","reactions","is","used","in","sugar","synthesis","in","dark","reactions",".","Light","reactions","also","generate","a","proton","motive","force","across","the","thylakoid","membrane",",","and","the","proton","gradient","is","used","to","synthesize","ATP",".","There","are","two","chemical","reactions","involved","in","the","light","reactions",":","water","oxidation","in","photosystem","II",",","and","NADP","reduction","in","photosystem","I","."),4022379). assertion_content_comment('tOboGo_Photosynthesis',s("The","synthesis","by","organisms","of","organic","chemical","compounds",",","especially","carbohydrates",",","from","carbon","dioxide","(","CO2",")","using","energy","obtained","from","light","rather","than","from","the","oxidation","of","chemical","compounds","."),4022377). assertion_content_comment('tOboGo_PhotosyntheticAcclimation',s("A","response","to","light","intensity","in","which","exposure","to","medium-intensity","light","results","in","increased","tolerance","to","high-intensity","light","."),4261229). assertion_content_comment('tOboGo_PhotosyntheticElectronTransportChain',s("A","process",",","occurring","as","part","of","photosynthesis",",","in","which","light","provides","the","energy","for","a","series","of","electron","carriers","to","operate","together","to","transfer","electrons","and","generate","a","transmembrane","electrochemical","gradient","."),4022393). assertion_content_comment('tOboGo_PhotosyntheticElectronTransportInPhotosystemII',s("A","photosynthetic","electron","transport","chain","in","which","electrons","move","from","the","primary","electron","acceptor","(","Quinone",",","Q",")","through","a","chain","of","electron","transport","molecules","in","the","thylakoid","membrane","until","they","reach","the","ultimate","electron","acceptor","of","Photosystem","II",",","which","is","plastocyanin","(","PC",")","The","electron","is","then","passed","to","the","P700","chlorophyll","a","molecules","of","the","reaction","centre","of","photosystem","I","."),4262831). assertion_content_comment('tOboGo_PhotosyntheticElectronTransportInPhotosystemI',s("A","photosynthetic","electron","transport","chain","in","which","electrons","move","from","the","primary","electron","acceptor","(","Quinone",",","X",")","through","a","chain","of","electron","transport","molecules","in","the","thylakoid","membrane","until","they","reach","ferredoxin","which","passes","the","electron","to","the","ultimate","electron","acceptor",";","NADP","."),4262822). assertion_content_comment('tOboGo_PhotosyntheticMembrane',s("A","membrane","enriched","in","complexes","formed","of","reaction","centers",",","accessory","pigments","and","electron","carriers",",","in","which","photosynthetic","reactions","take","place","."),4022534). assertion_content_comment('tOboGo_PhotosyntheticNADPReduction',s("An","NADPH","regeneration","process","that","contributes","to","the","light","reactions","of","photosynthesis",".","The","light","reactions","of","photosynthesis","use","energy","from","photons","to","generate","high-energy","electrons",".","These","electrons","are","used","directly","to","reduce","NADP","+","to","NADPH",".","NADPH","is","a","relatively","stable","molecule","and","can","pass","on","its","hydrogen","atom","to","other","molecules","in","chemical","reactions","."),4022428). assertion_content_comment('tOboGo_PhotosyntheticPhosphorylation',s("Any","metabolic","process","in","which","photosynthetic","organisms","use","light","energy","to","convert","ADP","to","ATP","without","the","concomitant","reduction","of","dioxygen","(","O2",")","to","water","that","occurs","in","phosphorylation","."),4022438). assertion_content_comment('tOboGo_PhotosyntheticWaterOxidation',s("OBSOLETE",".","Processes","by","which","a","molecule","of","water","is","oxidized","during","photosynthesis",".","P680","+",",","the","photochemically","oxidized","reaction-center","chlorophyll","of","PSII",",","is","a","strong","biological","oxidant",".","The","reduction","potential","of","P680","+","is","more","positive","than","that","of","water",",","and","thus","it","can","oxidize","water","to","give","O2","and","H","+","ions",".","The","oxygen","escapes","as","a","gas","while","the","H","+","ions","remain","in","solution","inside","the","thylakoid","vesicle","."),4262863). assertion_content_comment('tOboGo_PhotosystemIAntennaComplex',s("The","antenna","complex","of","photosystem","I",".","A","photosystem","has","two","closely","linked","components",",","an","antenna","containing","light-absorbing","pigments","and","a","reaction","center",".","Each","antenna","contains","one","or","more","light-harvesting","complexes","(","LHCs",")"),4022574). assertion_content_comment('tOboGo_PhotosystemIAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","photosystem","I","complex","on","the","thylakoid","membrane","."),4103017). assertion_content_comment('tOboGo_PhotosystemIIAntennaComplex',s("The","antenna","complex","of","photosystem","II",".","A","photosystem","has","two","closely","linked","components",",","an","antenna","containing","light-absorbing","pigments","and","a","reaction","center",".","Each","antenna","contains","one","or","more","light-harvesting","complexes","(","LHCs",")"),4022552). assertion_content_comment('tOboGo_PhotosystemIIAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","photosystem","II","complex","on","thylakoid","membrane",".","In","plants",",","the","photosystem","II","complex","consists","of","over","20","polypeptides","encoded","by","either","nuclear","or","chloroplast","genome","."),4031538). assertion_content_comment('tOboGo_PhotosystemIIOxygenEvolvingComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","oxygen","evolving","complex","(","OEC",")","of","photosystem","II","on","thylakoid","membrane",".","In","plants",",","the","photosystem","II","OEC","consists","of","three","extrinsic","nuclear-encoded","polypeptides",":","PsbO",",","PsbP","and","PsbQ",";","and","protects","the","CaMn4","cluster","bound","to","D1","and","CP43","proteins","."),4335318). assertion_content_comment('tOboGo_PhotosystemIIReactionCenter',s("An","integral","membrane","complex","containing","P680",",","the","chlorophyll","a","molecule","that","functions","as","a","primary","electron","donor",".","In","the","light",",","functioning","as","a","water-plastoquinone","oxidoreductase",",","it","transfers","electrons","from","water","to","plastoquinone","."),4023348). assertion_content_comment('tOboGo_PhotosystemIIRepair',s("Proteolysis","of","the","damaged","D1","protein","and","re-assembly","of","a","new","D1","subunit","in","the","Photosystem","II","following","photoinhibition","."),4031637). assertion_content_comment('tOboGo_PhotosystemII',s("A","photosystem","that","contains","a","pheophytin-quinone","reaction","center","with","associated","accessory","pigments","and","electron","carriers",".","In","cyanobacteria","and","chloroplasts",",","in","the","presence","of","light",",","PSII","functions","as","a","water-plastoquinone","oxidoreductase",",","transferring","electrons","from","water","to","plastoquinone",",","whereas","other","photosynthetic","bacteria","carry","out","anoxygenic","photosynthesis","and","oxidize","other","compounds","to","re-reduce","the","photoreaction","center","."),4022540). assertion_content_comment('tOboGo_PhotosystemIIStabilization',s("The","stabilization","of","the","photosystem","II","protein","complex",",","resulting","from","the","phosphorylation","of","its","structural","protein","subunits",",","in","a","cell","actively","involved","in","photosynthesis","."),4313192). assertion_content_comment('tOboGo_PhotosystemIReactionCenter',s("A","photochemical","system","containing","P700",",","the","chlorophyll","a","dimer","that","functions","as","a","primary","electron","donor",".","Functioning","as","a","light-dependent","plastocyanin-ferredoxin","oxidoreductase",",","it","transfers","electrons","from","plastocyanin","to","ferredoxin","."),4023334). assertion_content_comment('tOboGo_PhotosystemI',s("A","photosystem","that","contains","an","iron-sulfur","reaction","center","associated","with","accessory","pigments","and","electron","carriers",".","In","cyanobacteria","and","chloroplasts",",","photosystem","I","functions","as","a","light-dependent","plastocyanin-ferredoxin","oxidoreductase",",","transferring","electrons","from","plastocyanin","to","ferredoxin",";","in","photosynthetic","bacteria","that","have","only","a","single","type","I","photosystem",",","such","as","the","green","sulfur","bacteria",",","electrons","can","go","either","to","ferredoxin","(","Fd",")","-","&","gt",";","NAD","+","or","to","menaquinone","(","MK",")","-","&","gt",";","Cytb/FeS","-","&","gt",";","Cytc555","-","&","gt",";","photosystem","I","(","cyclic","photophosphorylation",")"),4022562). assertion_content_comment('tOboGo_PhotosystemIStabilization',s("The","stabilization","of","the","photosystem","I","protein","complex",",","resulting","from","the","phosphorylation","of","its","structural","protein","subunits",",","in","a","cell","actively","involved","in","photosynthesis","."),4313168). assertion_content_comment('tOboGo_Photosystem',s("A","complex","located","in","a","photosynthetic","membrane","that","consists","of","a","photoreaction","center","associated","with","accessory","pigments","and","electron","carriers",".","Examples","of","this","component","are","found","in","Arabidopsis","thaliana","and","in","photosynthetic","bacterial","and","archaeal","species","."),4022536). assertion_content_comment('tOboGo_PhotosystemStoichiometryAdjustment',s("Adjustment","of","Photosystem","I/Photosystem","II","ratio","in","response","to","light","conditions",".","The","function","of","photosystem","stoichiometry","adjustment","is","to","compensate","for","any","deficiency","in","energy","conversion","at","either","photosystem","I","or","photosystem","II","by","increasing","the","quantity","the","photosystem","that","will","otherwise","become","the","rate-limiting","to","overall","photosynthesis","."),4182874). assertion_content_comment('tOboGo_Phototaxis',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","light","."),4312922). assertion_content_comment('tOboGo_Phototransduction',s("The","sequence","of","reactions","within","a","cell","required","to","convert","absorbed","photons","into","a","molecular","signal","."),4020893). assertion_content_comment('tOboGo_PhototransductionUV',s("The","sequence","of","reactions","within","a","cell","required","to","convert","absorbed","photons","from","UV","light","into","a","molecular","signal",";","ultraviolet","radiation","is","electromagnetic","radiation","with","a","wavelength","in","the","range","of","10","to","380","nanometers","."),4234911). assertion_content_comment('tOboGo_PhototransductionVisibleLightLightAdaptation',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4247164). assertion_content_comment('tOboGo_PhototransductionVisibleLight',s("The","sequence","of","reactions","within","a","cell","required","to","convert","absorbed","photons","from","visible","light","into","a","molecular","signal",".","A","visible","light","stimulus","is","electromagnetic","radiation","that","can","be","perceived","visually","by","an","organism",";","for","organisms","lacking","a","visual","system",",","this","can","be","defined","as","light","with","a","wavelength","within","the","range","380","to","780","nm","."),4020909). assertion_content_comment('tOboGo_PhototrophinMediatedPhototransduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4261657). assertion_content_comment('tOboGo_Phototropism',s("The","movement","of","an","organism",",","or","part","of","an","organism",",","in","response","to","a","light","stimulus",",","usually","toward","or","away","from","it","."),4261211). assertion_content_comment('tOboGo_PhragmoplastAssembly',s("The","formation","of","a","structure","composed","of","actin",",","myosin",",","and","associated","proteins","that","will","function","in","cytokinesis","in","cells","that","perform","cytokinesis","by","cell","plate","formation",".","The","structure","usually","contains","antiparallel","microtubules","and","membrane","(","often","visible","as","vesicles",")"),3978688). assertion_content_comment('tOboGo_PhragmoplastMicrotubuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","structures","formed","of","microtubules","and","associated","proteins","in","phragmoplast",",","a","plant","cell","specific","structure","that","forms","during","late","cytokinesis",".","Phragmoplast","serves","as","a","scaffold","for","cell","plate","assembly","and","subsequent","formation","of","a","new","cell","wall","separating","the","two","daughter","cells","."),4181404). assertion_content_comment('tOboGo_Phragmoplast',s("Fibrous","structure","(","light","microscope","view",")","that","arises","between","the","daughter","nuclei","at","telophase","and","within","which","the","initial","partition","(","cell","plate",")",",","dividing","the","mother","cell","in","two","(","cytokinesis",")",",","is","formed",".","Appears","at","first","as","a","spindle","connected","to","the","two","nuclei",",","but","later","spreads","laterally","in","the","form","of","a","ring",".","Consists","of","microtubules","."),4261746). assertion_content_comment('tOboGo_Phragmosome',s("A","flattened","membranous","vesicle","containing","cell","wall","components","."),4261737). assertion_content_comment('tOboGo_PHReduction',s("Any","process","that","reduces","the","internal","pH","of","an","organism",",","part","of","an","organism","or","a","cell",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4069970). assertion_content_comment('tOboGo_PhthalateBinding',s("Interacting","selectively","and","non-covalently","with","a","phthalate",",","any","ester","or","salt","of","phthalic","acid","."),4382721). assertion_content_comment('tOboGo_PhthalateBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phthalate",",","any","ester","or","salt","of","phthalic","acid","."),4354098). assertion_content_comment('tOboGo_PhthalateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phthalate",",","the","anion","of","phthalic","acid","."),4354084). assertion_content_comment('tOboGo_PhthalateDioxygenaseReductaseActivity',s("Catalysis","of","the","transfer","of","electrons","between","pyridine","nucleotides","(","obligatory","two-electron","carriers",")","and","hemes","or","(","2Fe-2S",")","centers","(","obligatory","one-electron","carriers",")","in","respiration",",","photosynthesis",",","and","many","oxygenase","systems","."),4296990). assertion_content_comment('tOboGo_PhthalateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phthalate",",","the","anion","of","phthalic","acid",".","Phthalic","acid","diesters","are","used","industrially","in","the","production","of","a","variety","of","household","and","consumer","goods","including","plastic","polymers",",","lubricating","oils",",","and","carriers","for","perfumes","in","cosmetics",",","while","phthalic","acid","itself","is","used","industrially","as","a","plasticizer",".","Terephthalate","is","used","in","the","synthesis","of","polyethylene","terephthalate","(","polyethene","terephthlate",",","abbreviated","PET","or","PETE",")",",","a","plastic","polymer","with","many","commercial","uses","."),4272469). assertion_content_comment('tOboGo_PhthalylAmidaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","a","phthalylamide","=","phthalate","+","substituted","amine","."),4369860). assertion_content_comment('tOboGo_PhthiocerolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phthiocerol",",","a","lipid-based","1",",","3-glycol","consisting","of","(","3S",",","4R",")","-3-methoxy-4-methylnonacosane","having","(","9R",")","-","and","(","11S",")","-hydroxy","substituents","."),4074415). assertion_content_comment('tOboGo_Phycobilisome',s("Any","of","the","granules",",","approximately","32","nm","x","48","nm","and","consisting","of","highly","aggregated","phycobiliproteins",",","that","are","attached","in","arrays","to","the","external","face","of","a","thylakoid","membrane","in","algae","of","the","phyla","Cyanophyta","and","Rhodophyta",",","where","they","function","as","light-harvesting","devices","in","photosynthesis",".","Excitation","energy","in","the","phycobilisome","flows","in","the","sequence",":","phycoerythrin",",","phycocyanin",",","allophycocyanin","before","passing","to","the","antenna","chlorophyll","of","photosystem","II","."),4052900). assertion_content_comment('tOboGo_Phycocyanobilin_FerredoxinOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","(","3Z",")","-phycocyanobilin","+","oxidized","ferredoxin","=","biliverdin","IXa","+","reduced","ferredoxin","."),4277920). assertion_content_comment('tOboGo_Phycoerythrobilin_FerredoxinOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","(","3Z",")","-phycoerythrobilin","+","oxidized","ferredoxin","=","15",",","16-dihydrobiliverdin","+","reduced","ferredoxin","."),4278024). assertion_content_comment('tOboGo_PhyllomeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","phyllome","over","time",",","from","its","formation","to","the","mature","structure",".","A","phyllome","is","a","collective","term","for","all","the","different","types","of","leaves","appearing","on","plants","."),4029180). assertion_content_comment('tOboGo_PhylloquinoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phylloquinone",",","vitamin","K1",",","a","quinone-derived","compound","synthesized","by","green","plants","."),4312601). assertion_content_comment('tOboGo_PhylloquinoneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phylloquinone",",","vitamin","K1",",","a","quinone-derived","compound","synthesized","by","green","plants","."),4312656). assertion_content_comment('tOboGo_PhylloquinoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phylloquinone",",","a","quinone-derived","compound","synthesized","by","green","plants",".","Phylloquinone","has","vitamin","K","activity","and","is","known","as","vitamin","K1","."),4312581). assertion_content_comment('tOboGo_PhyllotacticPatterning',s("The","radial","pattern","formation","process","that","results","in","the","formation","of","leaf","or","flower","primordia","around","the","center","of","a","shoot","apical","meristem","."),4110927). assertion_content_comment('tOboGo_PhysiologicalCardiacMuscleHypertrophy',s("The","enlargement","or","overgrowth","of","all","or","part","of","the","heart","muscle","due","to","an","increase","in","size","of","cardiac","muscle","cells","without","cell","division",".","This","process","contributes","to","the","developmental","growth","of","the","heart","."),4001776). assertion_content_comment('tOboGo_PhysiologicalMuscleHypertrophy',s("The","enlargement","or","overgrowth","of","all","or","part","of","a","muscle","organ","or","tissue","due","to","an","increase","in","the","size","of","its","muscle","cells",".","Physiological","hypertrophy","is","a","normal","process","during","development","."),4194244). assertion_content_comment('tOboGo_PhytoalexinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytoalexins",",","any","of","a","range","of","substances","produced","by","plants","as","part","of","their","defense","response","."),4110306). assertion_content_comment('tOboGo_PhytoalexinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phytoalexins",",","any","of","a","range","of","substances","produced","by","plants","as","part","of","their","defense","response","."),4197042). assertion_content_comment('tOboGo_PhytoalexinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phytoalexins",",","any","of","a","range","of","substances","produced","by","plants","as","part","of","their","defense","response","."),4110303). assertion_content_comment('tOboGo_PhytoceramidaseActivity',s("Catalysis","of","the","reaction",":","a","phytoceramide","+","H2O","=","a","fatty","acid","+","phytosphingosine","."),4176458). assertion_content_comment('tOboGo_PhytochelatinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytochelatins",",","any","of","a","group","of","peptides","that","bind","metals","(","Cd",",","Zn",",","Cu",",","Pb",",","Hg",")","in","thiolate","coordination","complexes",".","The","structure","is","of","the","type","(","gamma-glutamyl-cysteinyl",")","n-glycine",",","where","n","is","2","to","11","."),4362142). assertion_content_comment('tOboGo_PhytochelatinImportIntoVacuole',s("The","directed","movement","of","phytochelatins","into","the","vacuole",".","Phytochelatins","are","a","group","of","peptides","that","bind","metals","(","Cd",",","Zn",",","Cu",",","Pb",",","Hg",")","in","thiolate","coordination","complexes","."),4169060). assertion_content_comment('tOboGo_PhytochelatinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phytochelatins",",","any","of","a","group","of","peptides","that","bind","metals","(","Cd",",","Zn",",","Cu",",","Pb",",","Hg",")","in","thiolate","coordination","complexes",".","The","structure","is","of","the","type","(","gamma-glutamyl-cysteinyl",")","n-glycine",",","where","n","is","2","to","11","."),4362139). assertion_content_comment('tOboGo_PhytochelatinTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","a","phytochelatin","across","a","membrane","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Phytochelatins","are","a","group","of","peptides","that","bind","metals","(","Cd",",","Zn",",","Cu",",","Pb",",","Hg",")","in","thiolate","coordination","complexes","."),4168889). assertion_content_comment('tOboGo_PhytochelatinTransmembraneTransport',s("The","directed","movement","of","a","phytochelatin","across","a","membrane","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Phytochelatins","are","a","group","of","peptides","that","bind","metals","(","Cd",",","Zn",",","Cu",",","Pb",",","Hg",")","in","thiolate","coordination","complexes","."),4168870). assertion_content_comment('tOboGo_PhytochelatinTransporterActivity',s("Enables","the","directed","movement","of","a","phytochelatin","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Phytochelatins","are","a","group","of","peptides","that","bind","metals","(","Cd",",","Zn",",","Cu",",","Pb",",","Hg",")","in","thiolate","coordination","complexes","."),4168887). assertion_content_comment('tOboGo_PhytochelatinTransport',s("The","directed","movement","of","a","phytochelatin","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Phytochelatins","are","a","group","of","peptides","that","bind","metals","(","Cd",",","Zn",",","Cu",",","Pb",",","Hg",")","in","thiolate","coordination","complexes","."),4168868). assertion_content_comment('tOboGo_PhytochromeBinding',s("Interacting","selectively","and","non-covalently","with","phytochrome","."),4332394). assertion_content_comment('tOboGo_PhytochromeChromophoreBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","phytochrome","chromophore",".","The","phytochrome","chromophore","is","a","linear","tetrapyrrolic","prosthetic","group","covalently","attached","to","the","large","soluble","protein","phytochrome",".","Light","absorption","by","the","phytochrome","chromophore","triggers","photoconversion","between","two","spectrally","distinct","forms","of","the","photoreceptor",":","Pr",",","the","red","light","absorbing","form",",","and","Pfr",",","the","far","red","light","absorbing","form","."),4332371). assertion_content_comment('tOboGo_PhytochromobilinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytochromobilin",",","which","involves","the","oxidative","cleavage","of","heme","by","a","heme","oxygenase","(","HO",")","to","form","biliverdin","IX","alpha","."),4330069). assertion_content_comment('tOboGo_Phytochromobilin_FerredoxinOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","(","3Z",")","-phytochromobilin","+","oxidized","ferredoxin","=","biliverdin","IXa","+","reduced","ferredoxin","."),4278035). assertion_content_comment('tOboGo_PhytochromobilinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phytochromobilin",",","the","linear","tetrapyrrole","chromophore","required","for","plant","phytochrome","photoactivity","."),4287490). assertion_content_comment('tOboGo_PhytoeneDehydrogenaseActivity',s("Catalysis","of","the","dehydrogenation","of","phytoene","to","produce","a","carotenoid","intermediate","such","as","phytofluene","."),4304182). assertion_content_comment('tOboGo_PhytoeneSynthaseActivity',s("Catalysis","of","the","reaction",":","prephytoene","pyrophosphate","=","phytoene","+","diphosphate","."),4358554). assertion_content_comment('tOboGo_PhytolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytol",",","(","2E",",","7R",",","11R",")","-3",",","7",",","11",",","15-tetramethylhexadec-2-en-1-ol","."),4338925). assertion_content_comment('tOboGo_PhytolKinaseActivity',s("Catalysis","of","the","reaction",":","phytol","+","CTP","=","phytyl","monophosphate","+","CDP","+","H","+"),4335271). assertion_content_comment('tOboGo_PhytolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phytol",",","(","2E",",","7R",",","11R",")","-3",",","7",",","11",",","15-tetramethylhexadec-2-en-1-ol","."),4338907). assertion_content_comment('tOboGo_PhytolSalvage',s("A","process","that","generates","phytol",",","(","2E",",","7R",",","11R",")","-3",",","7",",","11",",","15-tetramethylhexadec-2-en-1-ol",",","from","derivatives","of","it","without","de","novo","synthesis","."),4338932). assertion_content_comment('tOboGo_PhytosphingosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytosphingosine",",","(","2S",",","3S",",","4R",")","-2-aminooctadecane-1",",","3",",","4-triol","."),4172710). assertion_content_comment('tOboGo_PhytosphingosineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phytosphingosine",",","(","2S",",","3S",",","4R",")","-2-aminooctadecane-1",",","3",",","4-triol",",","a","constituent","of","many","plant","sphingolipids","."),4172704). assertion_content_comment('tOboGo_PhytosteroidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytosteroids",",","steroids","that","differ","from","animal","steroids","in","having","substitutions","at","C24","and/or","a","double","bond","at","C22",".","Phytosteroids","are","so","named","because","they","occur","in","higher","plants",";","some",",","notably","ergosterol",",","are","also","found","in","fungi","."),4029234). assertion_content_comment('tOboGo_PhytosteroidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phytosteroids",",","steroids","that","differ","from","animal","steroids","in","having","substitutions","at","C24","and/or","a","double","bond","at","C22",".","Phytosteroids","are","so","named","because","they","occur","in","higher","plants",";","some",",","notably","ergosterol",",","are","also","found","in","fungi","."),4302978). assertion_content_comment('tOboGo_PhytosteroidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phytosteroids",",","steroids","of","higher","plants","that","differ","from","animal","steroids","in","having","substitutions","at","C24","and/or","a","double","bond","at","C22",".","Phytosteroids","are","so","named","because","they","occur","in","higher","plants",";","some",",","notably","ergosterol",",","are","also","found","in","fungi","."),4029231). assertion_content_comment('tOboGo_PhytylDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytyl","diphosphate",",","(","2E",")","-3",",","7",",","11",",","15-tetramethylhexadec-2-en-1-yl","trihydrogen","diphosphate","."),4340692). assertion_content_comment('tOboGo_PhytylDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","phytyl","diphosphate",",","(","2E",")","-3",",","7",",","11",",","15-tetramethylhexadec-2-en-1-yl","trihydrogen","diphosphate","."),4340689). assertion_content_comment('tOboGo_PialSurfaceProcessExtension',s("The","extension","of","a","long","process","to","the","pial","surface","as","a","cell","leaves","the","ventricular","zone","."),4050026). assertion_content_comment('tOboGo_PiccoloNuA4HistoneAcetyltransferaseComplex',s("A","heterotrimeric","H4/H2A","histone","acetyltransferase","complex","with","a","substrate","preference","of","chromatin","over","free","histones",".","It","contains","a","subset","of","the","proteins","found","in","the","larger","NuA4","histone","acetyltransferase","complex",";","for","example",",","the","S",".","cerevisiae","complex","contains","Esa1p",",","Yng2p",",","and","Epl1p","."),4337542). assertion_content_comment('tOboGo_Picornain3CActivity',s("OBSOLETE",".","Catalysis","of","the","selective","cleavage","of","GlnGly","bond","in","the","poliovirus","polyprotein",".","In","other","picornavirus","reactions","Glu","may","be","substituted","for","Gln",",","and","Ser","or","Thr","for","Gly","."),4319258). assertion_content_comment('tOboGo_PiecemealMicroautophagyOfNucleus',s("Degradation","of","a","cell","nucleus","by","microautophagy","."),4129832). assertion_content_comment('tOboGo_PigmentAccumulationInResponseToUVLight',s("The","aggregation","of","coloring","matter","in","a","particular","location","in","an","organism",",","tissue","or","cell",",","occurring","in","response","to","a","UV","light","stimulus","."),4096072). assertion_content_comment('tOboGo_PigmentAccumulationInTissuesInResponseToUVLight',s("The","aggregation","of","coloring","matter","in","a","particular","location","in","a","tissue",",","occurring","in","response","to","a","UV","light","stimulus","."),4096086). assertion_content_comment('tOboGo_PigmentAccumulationInTissues',s("The","aggregation","of","coloring","matter","in","a","particular","location","in","a","tissue",",","occurring","in","response","to","an","external","stimulus","."),4096083). assertion_content_comment('tOboGo_PigmentAccumulation',s("The","aggregation","of","coloring","matter","in","a","particular","location","in","an","organism",",","tissue","or","cell",",","occurring","in","response","to","some","external","stimulus","."),4096021). assertion_content_comment('tOboGo_Pigmentation',s("The","deposition","or","aggregation","of","coloring","matter","in","an","organism",",","tissue","or","cell","."),4011781). assertion_content_comment('tOboGo_PigmentBinding',s("Interacting","selectively","and","non-covalently","with","a","pigment",",","any","general","or","particular","coloring","matter","in","living","organisms",",","e.g",".","melanin","."),4280957). assertion_content_comment('tOboGo_PigmentBiosyntheticProcessInvolvedInPigmentAccumulation',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pigment",",","any","general","or","particular","coloring","matter","in","living","organisms",",","resulting","in","pigment","accumulation","."),4096106). assertion_content_comment('tOboGo_PigmentBiosyntheticProcessInvolvedInPigmentGranuleMaturation',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pigment",",","contributing","to","the","process","in","which","a","membrane-bounded","organelle","develops","into","a","pigment","granule",".","Maturation","is","a","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","cell","or","structure","to","attain","its","fully","functional","state","."),4104884). assertion_content_comment('tOboGo_PigmentBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pigment",",","any","general","or","particular","coloring","matter","in","living","organisms",",","e.g",".","melanin","."),4014517). assertion_content_comment('tOboGo_PigmentCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","pigment",",","any","general","or","particular","coloring","matter","in","living","organisms",",","e.g",".","melanin","."),4031790). assertion_content_comment('tOboGo_PigmentCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","pigment","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","pigment","cell","fate","."),4136962). assertion_content_comment('tOboGo_PigmentCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","pigmented","cell",",","such","as","a","melanocyte","."),4086882). assertion_content_comment('tOboGo_PigmentCellPrecursorDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","pigment","cell","precursor","."),4330783). assertion_content_comment('tOboGo_PigmentGranuleAggregationInCellCenter',s("The","directed","movement","of","dispersed","pigment","granules","towards","the","center","of","the","cell","."),4282245). assertion_content_comment('tOboGo_PigmentGranuleDispersal',s("The","directed","movement","of","pigment","granules","within","a","cell","towards","the","cell","periphery","."),4282236). assertion_content_comment('tOboGo_PigmentGranuleLocalization',s("Any","process","in","which","a","pigment","granule","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell","."),4056438). assertion_content_comment('tOboGo_PigmentGranuleMaturation',s("Steps","required","to","form","a","membrane-bounded","organelle","into","a","pigment","granule","containing","pigment",".","Maturation","is","a","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","cell","or","structure","to","attain","its","fully","functional","state","."),4096136). assertion_content_comment('tOboGo_PigmentGranuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","pigment","granule","."),4104642). assertion_content_comment('tOboGo_PigmentGranule',s("A","small",",","subcellular","membrane-bounded","vesicle","containing","pigment","and/or","pigment","precursor","molecules",".","Pigment","granule","biogenesis","is","poorly","understood",",","as","pigment","granules","are","derived","from","multiple","sources","including","the","endoplasmic","reticulum",",","coated","vesicles",",","lysosomes",",","and","endosomes","."),4065363). assertion_content_comment('tOboGo_PigmentGranuleTransport',s("The","directed","movement","of","pigment","granules","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4183383). assertion_content_comment('tOboGo_PigmentMetabolicProcessInvolvedInDevelopmentalPigmentation',s("The","chemical","reactions","and","pathways","involving","pigment",",","any","general","or","particular","coloring","matter","in","living","organisms",",","e.g",".","melanin",",","occurring","during","the","deposition","of","coloring","matter","in","an","organ","or","organism","."),4078498). assertion_content_comment('tOboGo_PigmentMetabolicProcessInvolvedInPigmentAccumulation',s("The","chemical","reactions","and","pathways","involving","a","pigment",",","any","general","or","particular","coloring","matter","in","living","organisms",",","as","part","of","the","accumulation","of","pigment","."),4096032). assertion_content_comment('tOboGo_PigmentMetabolicProcessInvolvedInPigmentation',s("The","chemical","reactions","and","pathways","involving","a","pigment",",","any","general","or","particular","coloring","matter","in","living","organisms",",","resulting","in","the","deposition","or","aggregation","of","pigment","in","an","organism",",","tissue","or","cell","."),4078493). assertion_content_comment('tOboGo_PigmentMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pigment",",","any","general","or","particular","coloring","matter","in","living","organisms",",","e.g",".","melanin","."),4014499). assertion_content_comment('tOboGo_PilinFimbrilinExporterActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4289322). assertion_content_comment('tOboGo_PilusAssembly',s("The","assembly","of","a","pilus",",","a","short","filamentous","structure","on","a","bacterial","cell",",","flagella-like","in","structure","and","generally","present","in","many","copies",".","Pili","are","variously","involved","in","transfer","of","nucleic","acids",",","adherence","to","surfaces",",","and","formation","of","pellicles",".","Is","required","for","bacterial","conjugation",",","or","can","play","a","role","in","adherence","to","surfaces","(","when","it","is","called","a","fimbrium",")",",","and","in","the","formation","of","pellicles","."),4257316). assertion_content_comment('tOboGo_PilusOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","pilus",",","a","short","filamentous","structure","on","a","bacterial","cell",",","flagella-like","in","structure","and","generally","present","in","many","copies","."),4257313). assertion_content_comment('tOboGo_PilusPart',s("Any","constituent","part","of","a","pilus",",","a","proteinaceous","hair-like","appendage","on","the","surface","of","bacteria","ranging","from","2-8","nm","in","diameter","."),4096667). assertion_content_comment('tOboGo_PilusRetraction',s("The","process","of","withdrawing","a","pilus","back","into","a","cell","."),4317741). assertion_content_comment('tOboGo_Pilus',s("A","proteinaceous","hair-like","appendage","on","the","surface","of","bacteria","ranging","from","2-8","nm","in","diameter","."),4096651). assertion_content_comment('tOboGo_PilusShaft',s("The","long",",","slender",",","mid","section","of","a","pilus","."),4258657). assertion_content_comment('tOboGo_PilusTip',s("The","pointed","extremity","furthest","from","the","cell","of","a","pilus","."),4258635). assertion_content_comment('tOboGo_PinealGlandDevelopment',s("The","progression","of","the","pineal","gland","over","time","from","its","initial","formation","until","its","mature","state",".","The","pineal","gland","is","an","endocrine","gland","that","secretes","melatonin","and","is","involved","in","circadian","rhythms","."),4048076). assertion_content_comment('tOboGo_PineneCatabolicProcess',s("The","chemical","reactions","and","pathways","leading","to","the","breakdown","of","the","monoterpenoid","pinene",";","alpha-pinene","is","(","1S",",","5S",")","-2",",","6",",","6-trimethylbicyclo","[","3.1.1","]","hept-2-ene",",","and","beta-pinene","is","(","1S",",","5S",")","-6",",","6-dimethyl-2-methylenebicyclo","[","3.1.1","]","heptane","."),4347417). assertion_content_comment('tOboGo_PineneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","monoterpenoid","pinene",";","alpha-pinene","is","(","1S",",","5S",")","-2",",","6",",","6-trimethylbicyclo","[","3.1.1","]","hept-2-ene",",","and","beta-pinene","is","(","1S",",","5S",")","-6",",","6-dimethyl-2-methylenebicyclo","[","3.1.1","]","heptane","."),4273231). assertion_content_comment('tOboGo_PineneSynthaseActivity',s("Catalysis","of","the","reaction",":","geranyl","diphosphate","=","pinene","+","diphosphate","."),4268977). assertion_content_comment('tOboGo_PinholinActivity',s("Catalysis","of","the","temporally-regulated","formation","of","a","transmembrane","protein","hole","that","allows","the","passage","of","ions",",","causing","a","lethal",",","irreversible","depolarization","of","the","cell","membrane","."),4360148). assertion_content_comment('tOboGo_PinocarveolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","pinocarveol","=","pinocarvone","+","2","H","+","+","2","e-","."),4281658). assertion_content_comment('tOboGo_PinocarveolIsomeraseActivity',s("Catalysis","of","the","reaction",":","pinocarveol","=","carveol","."),4273869). assertion_content_comment('tOboGo_PinoresinolReductaseActivity',s("Catalysis","of","the","reaction",":","pinoresinol","+","NADPH","+","H","+","=","lariciresinol","+","NADP","+"),4335223). assertion_content_comment('tOboGo_PinosylvinSynthaseActivity',s("Catalysis","of","the","reaction",":","trans-cinnamoyl-CoA","+","3","H","(","+",")","+","3","malonyl-CoA","=","4","CO","(","2",")","+","4","CoA","+","pinosylvin","."),4263016). assertion_content_comment('tOboGo_Pirellulosome',s("A","cytoplasmic","structure","found","in","bacterial","phyla","Planctomycetes","and","Verrucomicrobia","containing","a","condensed","nucleoid","and","ribosomes","and","surrounded","by","an","intracytoplasmic","membrane",".","It","is","surrounded","by","ribosome-free","cytoplasm",",","in","a","compartment","called","the","paryphoplasm","."),4288013). assertion_content_comment('tOboGo_PiRNABinding',s("Interacting","selectively","and","non-covalently","with","a","piRNA",",","a","Piwi-associated","RNA",",","a","24-","to","30-nucleotide","RNA","derived","from","repeat","or","complex","DNA","sequence","elements","and","processed","by","a","Dicer-independent","mechanism","."),4352360). assertion_content_comment('tOboGo_PiRNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","piRNAs",",","Piwi-associated","RNAs",",","a","class","of","24-","to","30-nucleotide","RNA","derived","from","repeat","or","complex","DNA","sequence","elements","and","processed","by","a","Dicer-independent","mechanism","."),4352311). assertion_content_comment('tOboGo_PiRNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","piRNAs",",","Piwi-associated","RNAs",",","a","class","of","24-","to","30-nucleotide","RNA","derived","from","repeat","or","complex","DNA","sequence","elements","and","processed","by","a","Dicer-independent","mechanism","."),4352299). assertion_content_comment('tOboGo_PitrilysinActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","of","Tyr16-Leu17","and","Phe25-Tyr26","bonds","of","oxidized","insulin","B","chain",".","Also","acts","on","other","substrates","of","Molecular","weight","less","than","7","kDa","such","as","insulin","and","glucagon","."),4247945). assertion_content_comment('tOboGo_PituitaryAdenylateCyclaseActivatingPolypeptideActivity',s("The","action","characteristic","of","pituitary","adenylate","cyclase","activating","polypeptide",",","a","peptide","produced","in","the","hypothalamus","that","binds","to","receptors","to","exert","pleiotropic","effects","including","control","of","neurotransmitter","release",",","vasodilation",",","bronchodilation",",","activation","of","intestinal","motility",",","increase","in","insulin","and","histamine","secretion",",","immune","modulation",",","and","stimulation","of","cell","proliferation","and","differentiation","."),4305169). assertion_content_comment('tOboGo_PituitaryGlandDevelopment',s("The","progression","of","the","pituitary","gland","over","time","from","its","initial","formation","until","its","mature","state",".","The","pituitary","gland","is","an","endocrine","gland","that","secretes","hormones","that","regulate","many","other","glands","."),4046407). assertion_content_comment('tOboGo_PlacentaBloodVesselDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","blood","vessel","of","the","placenta","over","time",",","from","its","formation","to","the","mature","structure","."),4112485). assertion_content_comment('tOboGo_PlacentaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","placenta","over","time",",","from","its","formation","to","the","mature","structure",".","The","placenta","is","an","organ","of","metabolic","interchange","between","fetus","and","mother",",","partly","of","embryonic","origin","and","partly","of","maternal","origin","."),3986672). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInAxisElongation',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","to","modulate","cytoskeletal","elements","and","control","cell","polarity","that","contributes","to","axis","elongation","."),4004618). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInCardiacMuscleCellFateCommitment',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","effectors","other","than","beta-catenin","and","contributing","to","a","cardioblast","being","committed","to","a","cardiac","muscle","cell","fate","."),4261542). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInCardiacMuscleTissueMorphogenesis',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","via","downstream","effectors","including","C-Jun","N-terminal","kinase","(","JNK",")","to","modulate","cytoskeletal","elements","and","control","cell","polarity","that","contributes","to","the","shaping","of","the","cardiac","muscle","tissue","."),4135064). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInCardiacRightAtriumMorphogenesis',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","via","downstream","effectors","including","C-Jun","N-terminal","kinase","(","JNK",")","to","modulate","cytoskeletal","elements","and","control","cell","polarity","that","contributes","to","the","shaping","of","the","cardiac","right","atrium","."),4135084). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInGastrulaMediolateralIntercalation',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","via","downstream","effectors","including","C-Jun","N-terminal","kinase","(","JNK",")","contributing","to","the","interdigitation","of","cells","along","the","mediolateral","axis","during","gastrulation","."),4110948). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInHeartMorphogenesis',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","via","downstream","effectors","including","C-Jun","N-terminal","kinase","(","JNK",")","to","modulate","cytoskeletal","elements","and","control","cell","polarity","that","contributes","to","the","shaping","of","the","heart","."),4135044). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInNeuralTubeClosure',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","via","downstream","effectors","that","modulates","the","establishment","of","planar","polarity","contributing","to","neural","tube","closure","."),4141639). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInOutflowTractMorphogenesis',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","via","downstream","effectors","including","C-Jun","N-terminal","kinase","(","JNK",")","to","modulate","cytoskeletal","elements","and","control","cell","polarity","that","contributes","to","the","shaping","of","the","outflow","tract","."),4135054). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInPericardiumMorphogenesis',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","via","downstream","effectors","including","C-Jun","N-terminal","kinase","(","JNK",")","to","modulate","cytoskeletal","elements","and","control","cell","polarity","that","contributes","to","the","shaping","of","the","pericardium","."),4135115). assertion_content_comment('tOboGo_PlanarCellPolarityPathwayInvolvedInVentricularSeptumMorphogenesis',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","where","activated","receptors","signal","via","downstream","effectors","including","C-Jun","N-terminal","kinase","(","JNK",")","to","modulate","cytoskeletal","elements","and","control","cell","polarity","that","contributes","to","the","shaping","of","the","ventricular","septum","."),4135074). assertion_content_comment('tOboGo_PlanarDichotomousSubdivisionOfTerminalUnitsInvolvedInLungBranchingMorphogenesis',s("The","process","in","which","a","lung","bud","bifurcates","parallel","to","the","plane","of","the","previous","bud","."),4160653). assertion_content_comment('tOboGo_PlantCellPapilla',s("A","cell","projection","that","is","a","short",",","rounded","projection","from","a","plant","epidermal","cell","."),4155178). assertion_content_comment('tOboGo_PlantletFormationOnParentPlant',s("The","process","in","which","a","new","plantlet","develops","from","a","meristem","on","the","plant","body",".","As","part","of","this","process",",","when","the","plantlet","is","large","enough","to","live","independently",",","the","physical","connection","between","the","new","plantlet","and","the","main","plant","is","severed","."),4332692). assertion_content_comment('tOboGo_PlasmaCellDifferentiation',s("The","process","in","which","a","B","cell","acquires","the","specialized","features","of","a","plasma","cell",".","A","plasma","cell","is","a","lymphocyte","which","develops","from","a","B","cell","and","produces","high","amounts","of","antibody","."),4379855). assertion_content_comment('tOboGo_PlasmacytoidDendriticCellActivationInvolvedInImmuneResponse',s("A","change","in","the","morphology","or","behavior","of","a","plasmacytoid","dendritic","cell","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4377834). assertion_content_comment('tOboGo_PlasmacytoidDendriticCellActivation',s("A","change","in","the","morphology","or","behavior","of","a","plasmacytoid","dendritic","cell","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand","."),4377824). assertion_content_comment('tOboGo_PlasmacytoidDendriticCellAntigenProcessingAndPresentation',s("The","process","in","which","a","plasmacytoid","dendritic","cell","expresses","antigen","(","peptide","or","lipid",")","on","its","cell","surface","in","association","with","an","MHC","protein","complex","."),3994631). assertion_content_comment('tOboGo_PlasmacytoidDendriticCellChemotaxis',s("The","movement","of","a","plasmacytoid","dendritic","cell","in","response","to","an","external","stimulus","."),4381390). assertion_content_comment('tOboGo_PlasmacytoidDendriticCellCytokineProduction',s("Any","process","that","contributes","to","cytokine","production","by","a","plasmacytoid","dendritic","cell","."),3997143). assertion_content_comment('tOboGo_PlasmacytoidDendriticCellDifferentiationInvolvedInImmuneResponse',s("The","process","in","which","an","immature","plasmacytoid","dendritic","cell","acquires","the","specialized","features","of","a","mature","plasmacytoid","dendritic","cell","contributing","to","an","immune","response","."),4377855). assertion_content_comment('tOboGo_PlasmacytoidDendriticCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","hemopoietic","precursor","cell","acquires","the","specialized","features","of","a","plasmacytoid","dendritic","cell","."),4377853). assertion_content_comment('tOboGo_PlasmaGlycoprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217623). assertion_content_comment('tOboGo_PlasmaKallikreinActivity',s("OBSOLETE",".","Catalysis","of","the","selective","cleavage","of","Arg-Xaa","and","Lys-Xaa","bonds",",","including","Lys-Arg","and","Arg-Ser","bonds","in","(","human",")","kininogen","to","release","bradykinin","."),4187801). assertion_content_comment('tOboGo_PlasmaLipoproteinParticleAssembly',s("The","aggregation","and","arrangement","of","proteins","and","lipids","to","form","a","plasma","lipoprotein","particle","."),4075067). assertion_content_comment('tOboGo_PlasmaLipoproteinParticleClearance',s("The","process","in","which","a","lipoprotein","particle","is","removed","from","the","blood","via","receptor-mediated","endocytosis","and","its","constituent","parts","degraded","."),4035709). assertion_content_comment('tOboGo_PlasmaLipoproteinParticleDisassembly',s("The","disaggregation","of","a","plasma","lipoprotein","particle","into","its","constituent","components","."),4125695). assertion_content_comment('tOboGo_PlasmaLipoproteinParticleOrganization',s("A","protein-lipid","complex","subunit","organization","process","that","results","in","the","formation",",","disassembly",",","or","alteration","of","a","plasma","lipoprotein","particle",".","A","plasma","lipoprotein","particle","is","a","spherical","particle","with","a","hydrophobic","core","of","triglycerides","and/or","cholesterol","esters",",","surrounded","by","an","amphipathic","monolayer","of","phospholipids",",","cholesterol","and","apolipoproteins","."),4038036). assertion_content_comment('tOboGo_PlasmaLipoproteinParticleOxidation',s("The","modification","of","a","lipoprotein","by","oxidation","of","one","or","more","amino","acids","or","the","lipid","group",",","occurring","in","the","blood","plasma","."),4074861). assertion_content_comment('tOboGo_PlasmaLipoproteinParticleRemodeling',s("The","acquisition",",","loss","or","modification","of","a","protein","or","lipid","within","a","plasma","lipoprotein","particle",",","including","the","hydrolysis","of","triglyceride","by","hepatic","lipase",",","with","the","subsequent","loss","of","free","fatty","acid",",","and","the","esterification","of","cholesterol","by","phosphatidylcholine-sterol","O-acyltransferase","(","lecithin","cholesterol","acyltransferase",";","LCAT",")"),4038039). assertion_content_comment('tOboGo_PlasmaLipoproteinParticle',s("A","spherical","particle","with","a","hydrophobic","core","of","triglycerides","and/or","cholesterol","esters",",","surrounded","by","an","amphipathic","monolayer","of","phospholipids",",","cholesterol","and","apolipoproteins",".","Plasma","lipoprotein","particles","transport","lipids",",","which","are","non-covalently","associated","with","the","particles",",","in","the","blood","or","lymph","."),4075042). assertion_content_comment('tOboGo_PlasmalogenSynthaseActivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","1-O-alk-1-enyl-glycero-3-phosphocholine","=","CoA","+","plasmenylcholine","."),4264387). assertion_content_comment('tOboGo_PlasmaMembraneAcetateTransport',s("The","directed","movement","of","acetate","across","a","plasma","membrane","."),4228587). assertion_content_comment('tOboGo_PlasmaMembraneATPSynthesisCoupledElectronTransport',s("The","transfer","of","electrons","through","a","series","of","electron","donors","and","acceptors",",","generating","energy","that","is","ultimately","used","for","synthesis","of","ATP","in","the","plasma","membrane","."),4061098). assertion_content_comment('tOboGo_PlasmaMembraneATPSynthesisCoupledProtonTransport',s("The","transport","of","protons","across","the","plasma","membrane","to","generate","an","electrochemical","gradient","(","proton-motive","force",")","that","powers","ATP","synthesis","."),4317057). assertion_content_comment('tOboGo_PlasmaMembraneCopperIonTransport',s("The","directed","movement","of","copper","ions","across","the","plasma","membrane","."),4289986). assertion_content_comment('tOboGo_PlasmaMembraneCopperTransporter',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4216680). assertion_content_comment('tOboGo_PlasmaMembraneElectronTransportNADHToQuinone',s("The","transfer","of","electrons","from","NADH","to","the","quinone","pool","that","occurs","during","oxidative","phosphorylation","and","results","in","the","generation","of","a","proton","gradient",",","mediated","by","the","enzyme","known","as","NADH-quinone","oxidoreductase","."),4061109). assertion_content_comment('tOboGo_PlasmaMembraneEnrichedFraction',s("The","fraction","of","cells",",","prepared","by","disruptive","biochemical","methods",",","that","is","enriched","for","plasma","membranes","."),3988380). assertion_content_comment('tOboGo_PlasmaMembraneFumarateReductaseComplex',s("A","membrane-bound","flavoenzyme","complex","consisting","of","four","subunits",",","A",",","B",",","C",",","and","D",".","A","and","B","comprise","the","membrane-extrinsic","catalytic","domain","and","C","(","InterPro",":","IPR003510",";","InterPro",":","IPR00224",")","and","D","(","InterPro",":","IPR003418",")","link","the","catalytic","centers","to","the","electron-transport","chain",".","In","some","species",",","the","complex","has","only","three","subunits",",","and","in","these","cases",",","there","is","only","one","membrane","anchor","instead","of","two",".","This","family","consists","of","the","13","kDa","hydrophobic","subunit","D",".","This","component","may","be","required","to","anchor","the","catalytic","components","of","the","fumarate","reductase","complex","to","the","cytoplasmic","membrane",".","Fumarate","reductase","couples","the","reduction","of","fumarate","to","succinate","to","the","oxidation","of","quinol","to","quinone",",","in","a","reaction","opposite","to","that","catalyzed","by","the","related","complex","II","of","the","respiratory","chain","(","succinate","dehydrogenase-","(","ubiquinone",")",")","Examples","of","this","component","are","found","in","Bacterial","species","."),4085711). assertion_content_comment('tOboGo_PlasmaMembraneFusionInvolvedInCytogamy',s("The","joining","of","two","or","more","lipid","bilayer","membranes","that","surround","cells",",","that","contributes","to","cytogamy","."),4054151). assertion_content_comment('tOboGo_PlasmaMembraneFusion',s("The","joining","of","two","or","more","lipid","bilayer","membranes","that","surround","a","cell","."),4019175). assertion_content_comment('tOboGo_PlasmaMembraneOfCellTip',s("The","portion","of","the","plasma","membrane","surrounding","the","cell","tip","."),4060754). assertion_content_comment('tOboGo_PlasmaMembraneOrganizationInvolvedInConjugationWithCellularFusion',s("A","process","of","plasma","membrane","organization","that","contributes","to","conjugation","with","cellular","fusion","."),4132066). assertion_content_comment('tOboGo_PlasmaMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","plasma","membrane","."),3984767). assertion_content_comment('tOboGo_PlasmaMembranePart',s("Any","constituent","part","of","the","plasma","membrane",",","the","membrane","surrounding","a","cell","that","separates","the","cell","from","its","external","environment",".","It","consists","of","a","phospholipid","bilayer","and","associated","proteins","."),3973204). assertion_content_comment('tOboGo_PlasmaMembranePyruvateTransport',s("The","directed","movement","of","pyruvate",",","2-oxopropanoate",",","across","a","plasma","membrane","."),4228606). assertion_content_comment('tOboGo_PlasmaMembraneRepair',s("The","resealing","of","a","cell","plasma","membrane","after","cellular","wounding","due","to",",","for","instance",",","mechanical","stress","."),3984772). assertion_content_comment('tOboGo_PlasmaMembraneRespiratoryChainComplexIII',s("A","part","of","the","respiratory","chain","located","in","the","plasma","membrane",",","containing","about","10","polypeptide","subunits","including","four","redox","centers",":","cytochrome","b/b6",",","cytochrome","c1","and","an","2Fe-2S","cluster",".","Catalyzes","the","oxidation","of","ubiquinol","by","oxidized","cytochrome","c1",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4085599). assertion_content_comment('tOboGo_PlasmaMembraneRespiratoryChainComplexII',s("A","part","of","the","respiratory","chain","located","in","the","plasma","membrane",",","containing","the","four","polypeptide","subunits","of","succinate","dehydrogenase",",","flavin-adenine","dinucleotide","and","iron-sulfur",".","Catalyzes","the","oxidation","of","succinate","by","ubiquinone",".","Connects","the","TCA","cycle","with","the","respiratory","chain",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4085660). assertion_content_comment('tOboGo_PlasmaMembraneRespiratoryChainComplexI',s("A","subcomplex","of","the","respiratory","chain","located","in","the","plasma","membrane",".","It","contains","about","25","different","polypeptide","subunits",",","including","NADH","dehydrogenase","(","ubiquinone",")",",","flavin","mononucleotide","and","several","different","iron-sulfur","clusters","containing","non-heme","iron",".","The","iron","undergoes","oxidation-reduction","between","Fe","(","II",")","and","Fe","(","III",")",",","and","catalyzes","proton","translocation","linked","to","the","oxidation","of","NADH","by","ubiquinone",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4085673). assertion_content_comment('tOboGo_PlasmaMembraneRespiratoryChainComplexIVAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","respiratory","chain","complex","IV","(","also","known","as","cytochrome","c","oxidase",")","in","the","plasma","membrane","."),4063588). assertion_content_comment('tOboGo_PlasmaMembraneRespiratoryChainComplexIV',s("A","part","of","the","respiratory","chain","located","in","the","plasma","membrane",",","containing","the","13","polypeptide","subunits","of","cytochrome","c","oxidase",",","including","cytochrome","a","and","cytochrome","a3",".","Catalyzes","the","oxidation","of","reduced","cytochrome","c","by","dioxygen","(","O2",")","Examples","of","this","component","are","found","in","Bacterial","species","."),4085584). assertion_content_comment('tOboGo_PlasmaMembraneRespiratoryChain',s("A","respiratory","chain","located","in","the","plasma","membrane","of","a","cell",";","made","up","of","the","protein","complexes","that","form","the","mitochondrial","electron","transport","system","(","the","respiratory","chain",")",",","associated","with","the","plasma","membrane",".","The","respiratory","chain","complexes","transfer","electrons","from","an","electron","donor","to","an","electron","acceptor","and","are","associated","with","a","proton","pump","to","create","a","transmembrane","electrochemical","gradient","."),4085570). assertion_content_comment('tOboGo_PlasmaMembrane',s("The","membrane","surrounding","a","cell","that","separates","the","cell","from","its","external","environment",".","It","consists","of","a","phospholipid","bilayer","and","associated","proteins","."),3973195). assertion_content_comment('tOboGo_PlasmaMembraneSuccinateDehydrogenaseComplex',s("A","multimeric","complex","which","consists","of","flavoprotein","(","subunit","A",";","InterPro",":","IPR003952",")",",","iron-sulfur","protein","(","subunit","B",")","and","membrane-bound","cytochrome","b560","(","subunit","C",";","InterPro",":","IPR000701",")","In","some","Archaea",",","the","membrane-bound","subunits","(","C","or","C","and","D",")","do","not","necessarily","contain","heme",".","Membrane-bound","subunits","can","bind/react","with","quinones",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4085697). assertion_content_comment('tOboGo_PlasmaMembraneSuccinateDehydrogenaseComplexUbiquinone',s("The","enzyme",",","located","in","the","plasma","membrane",",","that","catalyzes","the","oxidation","of","succinate","and","ubiquinone","to","fumarate","and","ubiquinol",";","involved","in","aerobic","respiration",",","repressed","in","anaerobic","respiration","."),4298750). assertion_content_comment('tOboGo_PlasmaMembraneToEndosomeTransport',s("Transport","of","a","vesicle","from","the","plasma","membrane","to","the","endosome","."),4384854). assertion_content_comment('tOboGo_PlasmanylethanolamineDesaturaseActivity',s("Catalysis","of","the","reaction",":","O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine","+","donor-H2","+","O2","=","O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine","+","acceptor","+","2","H2O","."),4264485). assertion_content_comment('tOboGo_PlasmaProtein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217806). assertion_content_comment('tOboGo_PlasmatocyteDifferentiation',s("The","process","in","which","a","hemocyte","precursor","cell","acquires","the","characteristics","of","the","phagocytic","blood-cell","type",",","the","plasmatocyte",".","Plasmatocytes","are","a","class","of","arthropod","hemocytes","important","in","the","cellular","defense","response","."),4087188). assertion_content_comment('tOboGo_PlasmidBinding',s("OBSOLETE",".","Interacting","selectively","with","a","plasmid",",","an","extrachromosomal","genetic","element","usually","characterized","as","a","covalently","continuous","double","stranded","DNA","molecule","found","in","bacteria","and","some","other","microorganisms","."),4193321). assertion_content_comment('tOboGo_PlasmidCopyNumberMaintenance',s("The","maintenance","of","the","number","of","copies","of","extrachromosomal","plasmid","DNA","."),4114258). assertion_content_comment('tOboGo_PlasmidMaintenance',s("The","maintenance","of","the","integrity","of","extrachromosomal","plasmid","DNA",";","includes","processes","that","ensure","plasmids","are","retained","in","the","daughter","cells","after","cell","division","."),4114256). assertion_content_comment('tOboGo_PlasmidPartitioning',s("Any","process","in","which","plasmids","are","segregated","or","distributed","into","daughter","cells","upon","cell","division","."),4310723). assertion_content_comment('tOboGo_PlasmidRecombination',s("A","process","of","DNA","recombination","occurring","within","a","plasmid","or","between","plasmids","and","other","plasmids","or","DNA","molecules","."),4313944). assertion_content_comment('tOboGo_PlasminActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","of","Lys-Xaa","&","gt",";","Arg-Xaa",";","higher","selectivity","than","trypsin",".","Converts","fibrin","into","soluble","products","."),4209577). assertion_content_comment('tOboGo_PlasminInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","the","serine","endopeptidase","plasmin","."),4310677). assertion_content_comment('tOboGo_PlasminogenActivation',s("The","process","in","which","inactive","plasminogen","is","processed","to","active","plasmin",".","This","process","includes","cleavage","at","an","internal","Arg-Val","site","to","form","an","N-terminal","A-chain","and","C-terminal","B-chain","held","together","by","a","disulfide","bond",",","and","can","include","further","proteolytic","cleavage","events","to","remove","the","preactivation","peptide","."),4024876). assertion_content_comment('tOboGo_PlasminogenActivatorActivity',s("OBSOLETE",".","Catalysis","of","the","specific","cleavage","of","an","Arg-Val","bond","in","plasminogen","to","form","plasmin","."),4255967). assertion_content_comment('tOboGo_PlasmodesmaOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","plasmodesma",",","a","fine","cytoplasmic","channel",",","found","in","all","higher","plants",",","that","connects","the","cytoplasm","of","one","cell","to","that","of","an","adjacent","cell","."),4261080). assertion_content_comment('tOboGo_Plasmodesma',s("A","fine","cytoplasmic","channel",",","found","in","all","higher","plants",",","that","connects","the","cytoplasm","of","one","cell","to","that","of","an","adjacent","cell","."),4023273). assertion_content_comment('tOboGo_PlasmodesmatalCytoplasmicSleeve',s("The","space","between","the","plasma","membrane","and","the","desmotubule","of","a","plasmodesma","."),4023369). assertion_content_comment('tOboGo_PlasmodesmatalDesmotubule',s("A","tightly","wound","cylinder","of","membrane","that","is","located","within","the","plasmodesmal","pore","and","runs","the","length","of","the","plasmodesma",".","The","desmotubule","likely","provides","a","rigid","stability","to","plasmodesmata","and","confers","a","fixed","diameter","and","pore","size","to","the","plasmodesmal","canal",",","and","is","linked","to","the","endoplasmic","reticulum","in","each","of","the","adjacent","cell","."),4023286). assertion_content_comment('tOboGo_PlasmodesmatalEndoplasmicReticulum',s("Endoplasmic","reticulum","found","in","plasmodesmata",",","junctions","connecting","the","cytoplasm","of","adjacent","plant","cells","."),4023298). assertion_content_comment('tOboGo_PlasmodesmatalPlasmaMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","plasmodesma","."),4023380). assertion_content_comment('tOboGo_PlastidADPGPyrophosphorylaseComplex',s("An","ADPG","pyrophosphorylase","complex","found","in","a","plastid","."),4061516). assertion_content_comment('tOboGo_PlastidBiotinCarboxylaseComplex',s("A","biotin","carboxylase","complex","located","in","the","stroma","of","a","plastid","."),4054544). assertion_content_comment('tOboGo_PlastidChromosome',s("A","circular","DNA","molecule","containing","plastid","encoded","genes","."),4023321). assertion_content_comment('tOboGo_PlastidDNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","plastid","DNA","."),4066430). assertion_content_comment('tOboGo_PlastidDNAReplication',s("The","process","in","which","new","strands","of","DNA","are","synthesized","in","a","plastid","."),4337898). assertion_content_comment('tOboGo_PlastidEnvelope',s("The","double","lipid","bilayer","enclosing","a","plastid","and","separating","its","contents","from","the","rest","of","the","cytoplasm",";","includes","the","intermembrane","space","."),4023474). assertion_content_comment('tOboGo_PlastidFission',s("The","creation","of","two","or","more","plastids","by","division","of","one","plastid",".","A","plastid","is","any","member","of","a","family","of","organelles","found","in","the","cytoplasm","of","plants","and","some","protists",",","which","are","membrane-bounded","and","contain","DNA","."),4325674). assertion_content_comment('tOboGo_PlastidInheritance',s("The","partitioning","of","plastids","between","daughter","cells","at","cell","division","."),4261071). assertion_content_comment('tOboGo_PlastidInnerMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","inner","membrane","of","a","plastid","."),4261048). assertion_content_comment('tOboGo_PlastidInnerMembrane',s("The","inner",",","i.e",".","lumen-facing",",","lipid","bilayer","of","the","plastid","envelope",";","also","faces","the","plastid","stroma","."),4057280). assertion_content_comment('tOboGo_PlastidIntermembraneSpace',s("The","region","between","the","inner","and","outer","lipid","bilayers","of","the","plastid","envelope","."),4023485). assertion_content_comment('tOboGo_PlastidLargeRibosomalSubunit',s("The","larger","of","the","two","subunits","of","a","plastid","ribosome",".","Two","sites","on","the","ribosomal","large","subunit","are","involved","in","translation",":","the","aminoacyl","site","(","A","site",")","and","peptidyl","site","(","P","site",")"),3974563). assertion_content_comment('tOboGo_PlastidLocalization',s("Any","process","in","which","a","plastid","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell","."),4121805). assertion_content_comment('tOboGo_PlastidMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","either","of","the","lipid","bilayers","surrounding","a","plastid","."),4022672). assertion_content_comment('tOboGo_PlastidMembrane',s("Either","of","the","lipid","bilayers","that","surround","a","plastid","and","form","the","plastid","envelope","."),4030796). assertion_content_comment('tOboGo_PlastidMRNAEditingComplex',s("An","mRNA","editing","complex","found","in","a","plastid","."),4319165). assertion_content_comment('tOboGo_PlastidNucleoid',s("The","region","of","a","plastid","to","which","the","DNA","is","confined","."),4023310). assertion_content_comment('tOboGo_PlastidOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","plastid","."),4022660). assertion_content_comment('tOboGo_PlastidOuterMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","outer","membrane","of","a","plastid","."),4261059). assertion_content_comment('tOboGo_PlastidOuterMembrane',s("The","outer",",","i.e",".","cytoplasm-facing",",","lipid","bilayer","of","the","plastid","envelope","."),4030798). assertion_content_comment('tOboGo_PlastidPart',s("Any","constituent","part","of","a","plastid",",","a","member","of","a","family","of","organelles","found","in","the","cytoplasm","of","plants","and","some","protists",",","which","are","membrane-bounded","and","contain","DNA",".","Plant","plastids","develop","from","a","common","type",",","the","proplastid","."),3974482). assertion_content_comment('tOboGo_PlastidPEPRNAPolymeraseCoreEnzymeBinding',s("Interacting","selectively","and","non-covalently","with","the","bacterial-type","plastid","PEP","RNA","polymerase","core","enzyme",",","typically","consisting","of","two","alpha",",","one","beta",",","one","beta","prime",",","and","one","double","prime","subunit","."),4356131). assertion_content_comment('tOboGo_PlastidPyruvateDehydrogenaseComplex',s("Complex","that","carries","out","the","oxidative","decarboxylation","of","pyruvate","to","form","acetyl-CoA",";","comprises","subunits","possessing","three","catalytic","activities",":","pyruvate","dehydrogenase","(","E1",")",",","dihydrolipoamide","S-acetyltransferase","(","E2",")",",","and","dihydrolipoamide","dehydrogenase","(","E3",")","This","complex","is","found","in","plant","plastids","and","is","distinct","from","the","one","found","in","mitochondria","."),4335595). assertion_content_comment('tOboGo_PlastidRibosome',s("A","ribosome","contained","within","a","plastid","."),3974494). assertion_content_comment('tOboGo_PlastidRNAPolymeraseRegulatoryRegionDNABinding',s("Interacting","selectively","with","a","DNA","region","that","controls","the","transcription","of","a","region","of","DNA","by","a","plastid","RNA","polymerase",".","Binding","may","occur","as","a","sequence","specific","interaction","or","as","an","interaction","observed","only","once","a","factor","has","been","recruited","to","the","DNA","by","other","factors","."),4356595). assertion_content_comment('tOboGo_Plastid',s("Any","member","of","a","family","of","organelles","found","in","the","cytoplasm","of","plants","and","some","protists",",","which","are","membrane-bounded","and","contain","DNA",".","Plant","plastids","develop","from","a","common","type",",","the","proplastid","."),3974480). assertion_content_comment('tOboGo_PlastidSigmaFactorActivity',s("A","sigma","factor","that","binds","to","the","plastid","PEP","core","RNA","polymerase","enzyme","to","confer","promoter","specificity","."),4356141). assertion_content_comment('tOboGo_PlastidSingleSubunitTypeRNAPolymeraseActivity',s("Catalysis","of","the","reaction",":","nucleoside","triphosphate","+","RNA","(","n",")","=","diphosphate","+","RNA","(","n","+","1",")","Utilizes","a","DNA","template","that","contains","a","single","subunit","type","plastid","RNA","polymerase","specific","promoter","to","direct","initiation","and","catalyses","DNA-template-directed","extension","of","the","3","'","-end","of","an","RNA","strand","by","one","nucleotide","at","a","time",".","Can","initiate","a","chain","'","de","novo","'"),4355998). assertion_content_comment('tOboGo_PlastidSmallRibosomalSubunit',s("The","smaller","of","the","two","subunits","of","a","plastid","ribosome","."),3974529). assertion_content_comment('tOboGo_PlastidStroma',s("The","proteinaceous","ground","substance","of","plastids","."),3974492). assertion_content_comment('tOboGo_PlastidThylakoidLumen',s("The","volume","enclosed","by","a","plastid","thylakoid","membrane","."),4023417). assertion_content_comment('tOboGo_PlastidThylakoidMembrane',s("The","lipid","bilayer","membrane","of","any","thylakoid","within","a","plastid","."),4022747). assertion_content_comment('tOboGo_PlastidThylakoid',s("Any","thylakoid","within","a","plastid","."),4021850). assertion_content_comment('tOboGo_PlastidTranslation',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","protein","in","a","plastid",".","This","is","a","ribosome-mediated","process","in","which","the","information","in","messenger","RNA","(","mRNA",")","is","used","to","specify","the","sequence","of","amino","acids","in","the","protein",";","the","plastid","has","its","own","ribosomes","and","transfer","RNAs",",","and","uses","a","genetic","code","that","differs","from","the","nuclear","code","."),4331360). assertion_content_comment('tOboGo_PlastidTypeIIFattyAcidSynthaseComplex',s("OBSOLETE","A","fatty","acid","synthase","complex","in","which","each","polypeptide","chain","catalyzes","a","single","activity",",","located","in","a","plastid","."),4319749). assertion_content_comment('tOboGo_Plastocyanin',s("OBSOLETE",".","A","copper-containing","electron","carrier","acting","between","cytochrome","b","(","6",")","-f","and","P700","of","photosystem","I","."),4296638). assertion_content_comment('tOboGo_PlastoglobuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","plastoglobule",".","Plastoglobule","is","a","lipoprotein","particle","present","in","chloroplasts",".","They","are","rich","in","non-polar","lipids","(","triglycerides",",","esters",")","as","well","as","in","prenylquinones",",","plastoquinone","and","tocopherols",".","Plastoglobules","are","often","associated","with","thylakoid","membranes",",","suggesting","an","exchange","of","lipids","with","thylakoids","."),4147670). assertion_content_comment('tOboGo_Plastoglobule',s("A","lipoprotein","particle","present","in","chloroplasts",".","They","are","rich","in","non-polar","lipids","(","triglycerides",",","esters",")","as","well","as","in","prenylquinones",",","plastoquinone","and","tocopherols",".","Plastoglobules","are","often","associated","with","thylakoid","membranes",",","suggesting","an","exchange","of","lipids","with","thylakoids","."),4030846). assertion_content_comment('tOboGo_PlastoquinoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","plastoquinone",",","a","lipid-soluble","electron-transporting","coenzyme","present","in","the","chloroplast","."),4335643). assertion_content_comment('tOboGo_PlateletActivatingFactorBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","platelet","activating","factor",",","1-O-alkyl-2-acetyl-sn-glycerol","3-phosphocholine",",","where","alkyl","=","hexadecyl","or","octadecyl",".","Platelet","activating","factor","is","an","inflammatory","mediator","released","from","a","variety","of","cells","in","response","to","various","stimuli","."),4230694). assertion_content_comment('tOboGo_PlateletActivatingFactorMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","platelet","activating","factor",",","1-O-alkyl-2-acetyl-sn-glycerol","3-phosphocholine",",","where","alkyl","=","hexadecyl","or","octadecyl",".","Platelet","activating","factor","is","an","inflammatory","mediator","released","from","a","variety","of","cells","in","response","to","various","stimuli","."),4230688). assertion_content_comment('tOboGo_PlateletActivatingFactorProductionInvolvedInInflammatoryResponse',s("The","synthesis","or","release","of","platelet","activating","factor","following","a","stimulus","as","part","of","an","inflammatory","response",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),3995855). assertion_content_comment('tOboGo_PlateletActivatingFactorProduction',s("The","synthesis","or","release","of","platelet","activating","factor","following","a","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),3995841). assertion_content_comment('tOboGo_PlateletActivatingFactorReceptorActivity',s("Combining","with","platelet","activating","factor","to","initiate","a","change","in","cell","activity","."),4198977). assertion_content_comment('tOboGo_PlateletActivatingFactorReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","platelet","activating","factor","receptor","."),4324145). assertion_content_comment('tOboGo_PlateletActivatingFactorSecretionInvolvedInInflammatoryResponse',s("The","regulated","release","of","platelet","activating","factor","by","a","cell","or","group","of","cells","as","part","of","an","inflammatory","response","."),3995875). assertion_content_comment('tOboGo_PlateletActivatingFactorSecretion',s("The","regulated","release","of","platelet","activating","factor","by","a","cell","or","group","of","cells","."),3995872). assertion_content_comment('tOboGo_PlateletActivation',s("A","series","of","progressive",",","overlapping","events","triggered","by","exposure","of","the","platelets","to","subendothelial","tissue",".","These","events","include","shape","change",",","adhesiveness",",","aggregation",",","and","release","reactions",".","When","carried","through","to","completion",",","these","events","lead","to","the","formation","of","a","stable","hemostatic","plug","."),4027062). assertion_content_comment('tOboGo_PlateletAggregation',s("The","adhesion","of","one","platelet","to","one","or","more","other","platelets","via","adhesion","molecules","."),4131034). assertion_content_comment('tOboGo_PlateletAlphaGranuleLumen',s("The","volume","enclosed","by","the","membrane","of","the","platelet","alpha","granule","."),4062919). assertion_content_comment('tOboGo_PlateletAlphaGranuleMembrane',s("The","lipid","bilayer","surrounding","the","platelet","alpha","granule","."),4062930). assertion_content_comment('tOboGo_PlateletAlphaGranuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","platelet","alpha","granule",".","A","platelet","alpha","granule","is","a","secretory","organelle","found","in","blood","platelets","."),4178401). assertion_content_comment('tOboGo_PlateletAlphaGranule',s("A","secretory","organelle","found","in","blood","platelets",",","which","is","unique","in","that","it","exhibits","further","compartmentalization","and","acquires","its","protein","content","via","two","distinct","mechanisms",":","(","1",")","biosynthesis","predominantly","at","the","megakaryocyte","(","MK",")","level","(","with","some","vestigial","platelet","synthesis",")","(","e.g",".","platelet","factor","4",")","and","(","2",")","endocytosis","and","pinocytosis","at","both","the","MK","and","circulating","platelet","levels","(","e.g",".","fibrinogen","(","Fg",")","and","IgG",")"),4062898). assertion_content_comment('tOboGo_PlateletDegranulation',s("The","regulated","exocytosis","of","secretory","granules","containing","preformed","mediators","such","as","histamine","and","serotonin","by","a","platelet","."),3996294). assertion_content_comment('tOboGo_PlateletDenseGranuleLumen',s("The","volume","enclosed","by","the","membrane","of","the","platelet","dense","granule","."),4062989). assertion_content_comment('tOboGo_PlateletDenseGranuleMembrane',s("The","lipid","bilayer","surrounding","the","platelet","dense","granule","."),4062979). assertion_content_comment('tOboGo_PlateletDenseGranuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","platelet","dense","granule",".","A","platelet","dense","granule","is","an","electron-dense","granule","occurring","in","blood","platelets","that","stores","and","secretes","adenosine","nucleotides","and","serotonin",".","They","contain","a","highly","condensed","core","consisting","of","serotonin",",","histamine",",","calcium",",","magnesium",",","ATP",",","ADP",",","pyrophosphate","and","membrane","lysosomal","proteins","."),4159661). assertion_content_comment('tOboGo_PlateletDenseGranule',s("Electron-dense","granule","occurring","in","blood","platelets","that","stores","and","secretes","adenosine","nucleotides","and","serotonin",".","They","contain","a","highly","condensed","core","consisting","of","serotonin",",","histamine",",","calcium",",","magnesium",",","ATP",",","ADP",",","pyrophosphate","and","membrane","lysosomal","proteins","."),4062967). assertion_content_comment('tOboGo_PlateletDenseTubularNetworkLumen',s("The","volume","enclosed","by","the","membranes","of","the","platelet","dense","tubular","network","."),4062878). assertion_content_comment('tOboGo_PlateletDenseTubularNetworkMembrane',s("The","lipid","bilayer","surrounding","the","platelet","dense","tubular","network","."),4062889). assertion_content_comment('tOboGo_PlateletDenseTubularNetwork',s("A","network","of","membrane-bounded","compartments","found","in","blood","platelets",",","where","they","regulate","platelet","activation","by","sequestering","or","releasing","calcium",".","The","dense","tubular","network","exists","as","thin","elongated","membranes","in","resting","platelets",",","and","undergoes","a","major","ultrastructural","change",",","to","a","rounded","vesicular","form",",","upon","addition","of","thrombin","."),4062868). assertion_content_comment('tOboGo_PlateletFormation',s("The","process","in","which","platelets","bud","from","long","processes","extended","by","megakaryocytes","."),4311760). assertion_content_comment('tOboGo_PLCActivatingMetabotropicGlutamateReceptorActivity',s("A","G-protein","coupled","receptor","that","binds","glutamate","and","is","linked","to","the","inositol","1",",","4",",","5-trisphosphate/calcium","signaling","system","."),4383958). assertion_content_comment('tOboGo_PleatedSeptateJunction',s("A","septate","junction","in","which","regular","arrays","of","electron-dense","septae","span","the","intermembrane","space","."),4220613). assertion_content_comment('tOboGo_PMLBodyOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","PML","bodies",",","a","class","of","nuclear","body",";","they","react","against","SP100","auto-antibodies","(","PML","=","promyelocytic","leukemia",")"),4307760). assertion_content_comment('tOboGo_PMLBody',s("A","class","of","nuclear","body",";","they","react","against","SP100","auto-antibodies","(","PML",",","promyelocytic","leukemia",")",";","cells","typically","contain","10-30","PML","bodies","per","nucleus",";","alterations","in","the","localization","of","PML","bodies","occurs","after","viral","infection","."),4305939). assertion_content_comment('tOboGo_PodosomeAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","podosome",",","an","actin-rich","adhesion","structure","characterized","by","formation","upon","cell","substrate","contact","and","localization","at","the","substrate-attached","part","of","the","cell","."),4129413). assertion_content_comment('tOboGo_Podosome',s("An","actin-rich","adhesion","structure","characterized","by","formation","upon","cell","substrate","contact","and","localization","at","the","substrate-attached","part","of","the","cell",",","contain","an","F-actin-rich","core","surrounded","by","a","ring","structure","containing","proteins","such","as","vinculin","and","talin",",","and","have","a","diameter","of","0.5","mm","."),3992863). assertion_content_comment('tOboGo_PolarBodyExtrusionAfterMeioticDivisions',s("The","cell","cycle","process","in","which","two","small","cells","are","generated",",","as","byproducts","destined","to","degenerate",",","as","a","result","of","the","first","and","second","meiotic","divisions","of","a","primary","oocyte","during","its","development","to","a","mature","ovum",".","One","polar","body","is","formed","in","the","first","division","of","meiosis","and","the","other","in","the","second","division",";","at","each","division",",","the","cytoplasm","divides","unequally",",","so","that","the","polar","body","is","of","much","smaller","size","than","the","developing","oocyte",".","At","the","second","division","in","which","a","polar","body","is","formed",",","the","polar","body","and","the","developing","oocyte","each","contain","a","haploid","set","of","chromosomes","."),4081831). assertion_content_comment('tOboGo_PolarCellElongation',s("OBSOLETE",".","Cell","expansion","that","results","in","an","increase","in","cell","size","along","the","axis","of","an","organ","in","a","polarized","fashion","."),4333999). assertion_content_comment('tOboGo_Polarisome',s("Protein","complex","that","plays","a","role","in","determining","cell","polarity","by","directing","the","localized","assembly","of","actin","filaments","at","polarization","sites",";","in","Saccharomyces","the","polarisome","includes","Bni1p",",","Spa2p",",","Pea2p",",","and","Bud6p","."),3971439). assertion_content_comment('tOboGo_PolaritySpecificationOfAdaxialAbaxialAxis',s("The","process","resulting","in","the","establishment","of","polarity","along","the","adaxial/abaxial","axis",".","Adaxial","refers","to","being","situated","toward","an","axis","of","an","anatomical","structure",".","Abaxial","refers","to","being","situated","away","from","an","axis","of","an","anatomical","structure","."),4033325). assertion_content_comment('tOboGo_PolaritySpecificationOfAnteriorPosteriorAxis',s("Any","process","resulting","in","the","establishment","of","polarity","along","the","anterior/posterior","axis","."),4033222). assertion_content_comment('tOboGo_PolaritySpecificationOfDorsalVentralAxis',s("Any","process","resulting","in","the","establishment","of","polarity","along","the","dorsal/ventral","axis","."),4033200). assertion_content_comment('tOboGo_PolaritySpecificationOfProximalDistalAxis',s("Any","process","resulting","in","the","establishment","of","polarity","along","the","proximal/distal","axis","."),4032256). assertion_content_comment('tOboGo_PolarizedEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","polarized","epithelial","cell",".","The","polarized","epithelial","cell","can","be","any","of","the","cells","within","an","epithelium","where","the","epithelial","sheet","is","oriented","with","respect","to","the","planar","axis","."),4002074). assertion_content_comment('tOboGo_PolarMicrotubule',s("Any","of","the","spindle","microtubules","that","come","from","each","pole","and","overlap","at","the","spindle","midzone",".","This","interdigitating","structure","consisting","of","antiparallel","microtubules","is","responsible","for","pushing","the","poles","of","the","spindle","apart","."),4007194). assertion_content_comment('tOboGo_PolarNucleusFusion',s("The","merging","of","the","polar","nuclei",",","the","two","nuclei","contained","within","the","same","cell","that","are","created","from","the","mitotic","division","of","the","megaspore","during","angiosperm","reproduction",".","Polar","nuclear","fusion","takes","place","in","the","ovule",",","forming","in","the","fusion","nucleus","and","giving","rise","to","the","endosperm","when","fertilized","."),4031662). assertion_content_comment('tOboGo_PolarNucleus',s("Either","of","two","nuclei","located","centrally","in","a","flowering","plant","embryo","sac","that","eventually","fuse","to","form","the","endosperm","nucleus","."),4317835). assertion_content_comment('tOboGo_PolarRingOfApicalComplex',s("An","electron","dense","ring","at","the","most","anterior","position","of","the","apical","complex",",","from","which","the","conoid","fibers","originate",";","formed","during","an","invasive","life","cycle","stage","of","an","apicomplexan","parasite","."),4041708). assertion_content_comment('tOboGo_PolarTube',s("A","highly","specialized","structure","unique","to","microsporidia","that","is","required","for","host","cell","invasion",".","In","the","spore",",","the","polar","tube","is","connected","at","the","anterior","end",",","and","then","coils","around","the","sporoplasm",".","Upon","appropriate","environmental","stimulation",",","the","polar","tube","rapidly","discharges","out","of","the","spore",",","pierces","a","cell","membrane","and","serves","as","a","conduit","for","sporoplasm","passage","into","the","new","host","cell","."),4288824). assertion_content_comment('tOboGo_PoleCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pole","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4017077). assertion_content_comment('tOboGo_PoleCellFateDetermination',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","pole","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4017089). assertion_content_comment('tOboGo_PoleCellFormation',s("Formation","of","a","small","group","of","cells","(","pole","cells",")","at","the","posterior","pole","of","the","insect","blastula",".","They","are","the","first","cells","to","cellularize","after","the","arrival","of","nuclei","at","the","end","of","the","syncytial","blastula","stage","and","are","the","precursors","to","the","insect","germ","cells","."),4017101). assertion_content_comment('tOboGo_PoleCellMigration',s("The","directed","movement","of","a","pole","cell","(","germline","progenitors","in","insects",")","from","its","site","of","production","at","the","posterior","pole","of","the","embryo","through","to","the","site","where","the","gonads","will","form","."),4235716). assertion_content_comment('tOboGo_PolePlasmAssembly',s("Establishment","of","the","specialized","cytoplasm","found","at","the","poles","of","the","egg",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4018957). assertion_content_comment('tOboGo_PolePlasmMitochondrialLrRNALocalization',s("Any","process","in","which","mitochondrial","large","ribosomal","RNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4236611). assertion_content_comment('tOboGo_PolePlasmMitochondrialRRNALocalization',s("Any","process","in","which","mitochondrial","ribosomal","RNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4236598). assertion_content_comment('tOboGo_PolePlasmMitochondrialSrRNALocalization',s("Any","process","in","which","mitochondrial","small","ribosomal","RNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4236624). assertion_content_comment('tOboGo_PolePlasmMRNALocalization',s("Any","process","in","which","mRNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4019041). assertion_content_comment('tOboGo_PolePlasmOskarMRNALocalization',s("Any","process","in","which","oskar","mRNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm","."),4019048). assertion_content_comment('tOboGo_PolePlasmProteinLocalization',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4018982). assertion_content_comment('tOboGo_PolePlasmRNALocalization',s("Any","process","in","which","RNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4018968). assertion_content_comment('tOboGo_PolePlasm',s("Differentiated","cytoplasm","associated","with","a","pole","(","animal",",","vegetal",",","anterior",",","or","posterior",")","of","an","oocyte",",","egg","or","early","embryo","."),4092975). assertion_content_comment('tOboGo_Polkadots',s("A","punctate",",","filamentous","structure","composed","of","Bcl10","that","appears","in","the","cytoplasm","of","T-cells","shortly","after","T-cell","receptor","stimulation",".","Polkadots","stands","for","Punctate","Oligomeric","Killing","and","Activating","DOmains","Transducing","Signals","."),4373475). assertion_content_comment('tOboGo_PollenAdhesion',s("The","process","in","which","pollen","deposited","on","the","stigma","adheres","to","cells","of","the","stigma","."),4022203). assertion_content_comment('tOboGo_PollenCoat',s("A","layer","of","extracellular","matrix","deposited","onto","the","surface","of","the","pollen","wall","upon","disintegration","of","the","tapetal","layer","of","the","anther","wall","in","the","late","stages","of","pollen","development",".","The","composition","of","this","material","is","highly","heterogeneous","and","includes","waxes",",","lipid","droplets",",","small","aromatic","molecules",",","and","proteins",".","The","pollen","coat","is","proposed","to","have","many","functions",",","such","as","holding","pollen","in","the","anther","until","dispersal",",","facilitation","of","pollen","dispersal",",","protection","of","pollen","from","water","loss","and","UV","radiation",",","and","facilitation","of","adhesion","of","pollen","to","the","stigma","."),4174823). assertion_content_comment('tOboGo_PollenDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pollen","grain","over","time",",","from","its","formation","to","the","mature","structure",".","The","process","begins","with","the","meiosis","of","the","microsporocyte","to","form","four","haploid","microspores",".","The","nucleus","of","each","microspore","then","divides","by","mitosis","to","form","a","two-celled","organism",",","the","pollen","grain",",","that","contains","a","tube","cell","as","well","as","a","smaller","generative","cell",".","The","pollen","grain","is","surrounded","by","an","elaborate","cell","wall",".","In","some","species",",","the","generative","cell","immediately","divides","again","to","give","a","pair","of","sperm","cells",".","In","most","flowering","plants",",","however","this","division","takes","place","later",",","in","the","tube","that","develops","when","a","pollen","grain","germinates","."),4023101). assertion_content_comment('tOboGo_PollenExineFormation',s("The","formation","of","the","pollen","exine",".","The","reticulate","pollen","wall","pattern","consists","of","two","layers",",","exine","and","intine","."),4147537). assertion_content_comment('tOboGo_PollenGermination',s("The","physiological","and","developmental","changes","that","occur","in","a","heterosporous","plant","pollen","grain",",","beginning","with","hydration","and","terminating","with","the","emergence","of","the","pollen","tube","through","the","aperture","."),4021793). assertion_content_comment('tOboGo_PollenHydration',s("The","process","in","which","water","is","taken","up","by","pollen","."),4022118). assertion_content_comment('tOboGo_PollenMaturation',s("The","final","stages","of","microgametogenesis","after","the","trinucleate","stage","has","been","reached","resulting","in","viable","pollen","grains","."),4031737). assertion_content_comment('tOboGo_PollenSpermCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","haploid","sperm","cell","within","the","plant","gametophyte","."),4103987). assertion_content_comment('tOboGo_PollenTubeAdhesion',s("The","process","in","which","the","pollen","tube","adheres","to","cells","of","the","stigma","and","style","."),4021973). assertion_content_comment('tOboGo_PollenTubeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","pollen","tube","over","time",",","from","its","initial","formation","to","a","mature","structure","."),4021971). assertion_content_comment('tOboGo_PollenTubeGrowth',s("Growth","of","pollen","via","tip","extension","of","the","intine","wall","."),4022108). assertion_content_comment('tOboGo_PollenTubeGuidance',s("The","process","in","which","the","growth","of","pollen","tube","is","directed","towards","the","female","gametophyte","."),4031758). assertion_content_comment('tOboGo_PollenTubeReception',s("Interaction","between","the","pollen","tube",",","part","of","the","male","gametophyte",",","and","the","ovule",",","part","of","the","female","gametophyte",",","that","results","in","the","arrest","of","pollen","tube","growth",",","rupture","of","the","pollen","tube","and","the","release","of","the","sperm","cells","."),4029598). assertion_content_comment('tOboGo_PollenTube',s("A","tubular","cell","projection","that","is","part","of","a","pollen","tube","cell","and","extends","from","a","pollen","grain","."),4151400). assertion_content_comment('tOboGo_PollenTubeTip',s("The","region","at","growing","end","of","the","pollen","tube","cell",",","where","polarized","growth","occurs","."),4151411). assertion_content_comment('tOboGo_PollenWallAssembly',s("The","formation","of","reticulate","pollen","wall","pattern","consisting","of","two","layers",",","exine","and","intine","."),4031549). assertion_content_comment('tOboGo_PollenWall',s("The","complex","wall","surrounding","a","pollen","grain","."),4094987). assertion_content_comment('tOboGo_Pollination',s("The","cascade","of","biological","processes","occurring","in","plants","beginning","when","the","pollen","lands","on","the","stigma","and","continuing","up","to",",","but","not","including",",","fertilization",",","as","defined","by","sperm-central","cell","fusion","."),4021783). assertion_content_comment('tOboGo_PoloKinaseKinaseActivity',s("Catalysis","of","the","addition","of","a","phosphate","group","onto","a","serine","or","threonine","residue","in","any","member","of","the","polo","kinase","class","of","proteins","."),4314768). assertion_content_comment('tOboGo_PolyamineAcetylation',s("The","modification","of","polyamines","by","addition","of","acetyl","groups","."),4337021). assertion_content_comment('tOboGo_PolyamineBinding',s("Interacting","selectively","and","non-covalently","with","polyamines",",","organic","compounds","containing","two","or","more","amino","groups","."),4233329). assertion_content_comment('tOboGo_PolyamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","polyamines",",","any","organic","compound","containing","two","or","more","amino","groups","."),4035571). assertion_content_comment('tOboGo_PolyamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","polyamines",",","any","organic","compound","containing","two","or","more","amino","groups","."),4210980). assertion_content_comment('tOboGo_PolyamineHomeostasis',s("Any","biological","process","involved","in","the","maintenance","of","an","internal","steady","state","of","a","polyamine","."),4336270). assertion_content_comment('tOboGo_Polyamine_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","H","+","(","out",")","+","polyamine","(","in",")","=","H","+","(","in",")","+","polyamine","(","out",")"),4296511). assertion_content_comment('tOboGo_PolyamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","polyamines",",","any","organic","compound","containing","two","or","more","amino","groups","."),4035567). assertion_content_comment('tOboGo_PolyamineOxidaseActivity',s("Catalysis","of","the","oxidative","degradation","or","interconversion","of","polyamines","."),4358705). assertion_content_comment('tOboGo_PolyamineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","polyamines",",","organic","compounds","containing","two","or","more","amino","groups",",","from","one","side","of","the","membrane","to","the","other","."),4289493). assertion_content_comment('tOboGo_PolyamineTransport',s("The","directed","movement","of","polyamines",",","organic","compounds","containing","two","or","more","amino","groups",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293886). assertion_content_comment('tOboGo_PolyAMRNAExportFromNucleus',s("The","directed","movement","of","poly","(","A",")","+","mRNA","out","of","the","nucleus","into","the","cytoplasm","."),4302517). assertion_content_comment('tOboGo_PolyARNABinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","adenylyl","residues","in","an","RNA","molecule",",","such","as","the","poly","(","A",")","tail",",","a","sequence","of","adenylyl","residues","at","the","3","'","end","of","eukaryotic","mRNA","."),4224090). assertion_content_comment('tOboGo_PolycistronicMRNAProcessing',s("The","conversion","of","a","primary","mRNA","transcript","containing","more","than","one","complete","protein-coding","region","into","individual","mature","mRNA","molecules","."),4321326). assertion_content_comment('tOboGo_PolyCRNABinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","cytosine","residues","in","an","RNA","molecule","."),4257951). assertion_content_comment('tOboGo_PolycystinComplex',s("A","stable","heterodimeric","complex","composed","of","polycystin-1","and","polycystin-2","."),4375463). assertion_content_comment('tOboGo_PolydeoxyribonucleotideKinaseActivity',s("Catalysis","of","the","reaction",":","NTP","+","5","'","-dephospho-DNA","=","NDP","+","5","'","-phospho-DNA","."),4280991). assertion_content_comment('tOboGo_PolyenoicFattyAcidIsomeraseActivity',s("Catalysis","of","the","reaction",":","all-cis-icosa-5",",","8",",","11",",","14",",","17-pentaenoate","=","(","5Z",",","7E",",","9E",",","14Z",",","17Z",")","-icosapentaenoate","."),4360694). assertion_content_comment('tOboGo_Polyferredoxin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4296720). assertion_content_comment('tOboGo_PolygalacturonaseActivity',s("Catalysis","of","the","random","hydrolysis","of","1",",","4-alpha-D-galactosiduronic","linkages","in","pectate","and","other","galacturonans","."),4203400). assertion_content_comment('tOboGo_PolygalacturonaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","polygalacturonase",".","Polygalacturonases","catalyze","the","random","hydrolysis","of","1",",","4-alpha-D-galactosiduronic","linkages","in","pectate","and","other","galacturonans","."),4155304). assertion_content_comment('tOboGo_PolyGRNABinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","guanine","residues","in","an","RNA","molecule","."),4360900). assertion_content_comment('tOboGo_PolyhedralOrganelle',s("An","organelle","found","in","bacteria","consisting","of","a","proteinaceous","coat","containing","metabolic","enzymes","whose","purpose","is","the","sequestration","or","concentration","of","metabolites","and","which","has","the","appearance","of","a","polygonal","granule","by","electron","microscopy","."),4321606). assertion_content_comment('tOboGo_PolyketideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","polyketides",",","any","of","a","diverse","group","of","natural","products","synthesized","via","linear","poly-beta-ketones",",","which","are","themselves","formed","by","repetitive","head-to-tail","addition","of","acetyl","(","or","substituted","acetyl",")","units","indirectly","derived","from","acetate","(","or","a","substituted","acetate",")","by","a","mechanism","similar","to","that","for","fatty","acid","biosynthesis","but","without","the","intermediate","reductive","steps","."),4262396). assertion_content_comment('tOboGo_PolyketideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","polyketides",",","any","of","a","diverse","group","of","natural","products","synthesized","via","linear","poly-beta-ketones",",","which","are","themselves","formed","by","repetitive","head-to-tail","addition","of","acetyl","(","or","substituted","acetyl",")","units","indirectly","derived","from","acetate","(","or","a","substituted","acetate",")","by","a","mechanism","similar","to","that","for","fatty","acid","biosynthesis","but","without","the","intermediate","reductive","steps","."),4308186). assertion_content_comment('tOboGo_PolyketideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","polyketides",",","any","of","a","diverse","group","of","natural","products","synthesized","via","linear","poly-beta-ketones",",","which","are","themselves","formed","by","repetitive","head-to-tail","addition","of","acetyl","(","or","substituted","acetyl",")","units","indirectly","derived","from","acetate","(","or","a","substituted","acetate",")","by","a","mechanism","similar","to","that","for","fatty","acid","biosynthesis","but","without","the","intermediate","reductive","steps","."),4026498). assertion_content_comment('tOboGo_PolyketideSynthaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4303963). assertion_content_comment('tOboGo_PolyketideSynthaseComplex',s("A","protein","complex","that","carries","out","enzymatic","reactions","involved","in","the","biosynthesis","of","polyketides",",","any","of","a","diverse","group","of","natural","products","synthesized","via","linear","poly-beta-ketones","."),4303958). assertion_content_comment('tOboGo_PolymannuronateHydrolaseActivity',s("Catalysis","of","the","endohydrolysis","of","the","D-mannuronide","linkages","of","polymannuronate","."),4344833). assertion_content_comment('tOboGo_PolymericIgAImmunoglobulinComplex',s("A","protein","complex","composed","of","two",",","three",",","or","four","monomeric","IgA","immunoglobulin","complexes","linked","through","both","direct","disulfide","bonds","and","through","disulfide","binded","monomers","of","J","chain","acting","as","a","bridge",".","Each","IgA","monomer","consists","of","two","identical","immunoglobulin","heavy","chains","of","an","IgA","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","Dimeric","IgA","is","sometimes","complexed","additionally","with","secretory","component",",","and","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169571). assertion_content_comment('tOboGo_PolymericImmunoglobulinBinding',s("Interacting","selectively","and","non-covalently","with","a","J-chain-containing","polymeric","immunoglobulin","of","the","IgA","or","IgM","isotypes","."),4383359). assertion_content_comment('tOboGo_PolymericImmunoglobulinReceptorActivity',s("Combining","with","a","J-chain-containing","polymeric","immunoglobulin","of","the","IgA","or","IgM","isotypes","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4383369). assertion_content_comment('tOboGo_PolymyxinTransporterActivity',s("Enables","the","directed","movement","of","polymyxin",",","any","of","a","group","of","related","antibiotics","produced","by","Bacillus","polymyxa","and","active","against","most","Gram-negative","bacteria",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4315096). assertion_content_comment('tOboGo_PolymyxinTransport',s("The","directed","movement","of","polymyxin",",","any","of","a","group","of","related","antibiotics","produced","by","Bacillus","polymyxa","and","active","against","most","Gram-negative","bacteria",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4314900). assertion_content_comment('tOboGo_PolynucleotideAdenylyltransferaseActivity',s("Catalysis","of","the","template-independent","extension","of","the","3","'","-","end","of","an","RNA","or","DNA","strand","by","addition","of","one","adenosine","molecule","at","a","time",".","Cannot","initiate","a","chain","'","de","novo","'","The","primer",",","depending","on","the","source","of","the","enzyme",",","may","be","an","RNA","or","DNA","fragment",",","or","oligo","(","A",")","bearing","a","3","'","-OH","terminal","group","."),4203350). assertion_content_comment('tOboGo_PolyolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","polyol",",","any","alcohol","containing","three","or","more","hydroxyl","groups","attached","to","saturated","carbon","atoms","."),4010582). assertion_content_comment('tOboGo_PolyolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","polyol",",","any","alcohol","containing","three","or","more","hydroxyl","groups","attached","to","saturated","carbon","atoms","."),4225015). assertion_content_comment('tOboGo_PolyolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","polyol",",","any","alcohol","containing","three","or","more","hydroxyl","groups","attached","to","saturated","carbon","atoms","."),4010551). assertion_content_comment('tOboGo_PolyolTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","polyol","from","one","side","of","the","membrane","to","the","other",".","A","polyol","is","any","polyhydric","alcohol","."),4179023). assertion_content_comment('tOboGo_PolyolTransport',s("The","directed","movement","of","polyols",",","any","polyhydric","alcohol",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4151260). assertion_content_comment('tOboGo_PolyphenicDeterminationInfluenceByEnvironmentalFactors',s("The","process","in","which","individuals","that","have","the","potential","to","develop","any","of","several","possible","distinct","developmental","paths","have","their","individual","developmental","fates","determined","in","response","to","environmental","cues","."),4332671). assertion_content_comment('tOboGo_PolyphenicDeterminationInfluenceByGeneticFactors',s("The","process","in","which","individuals","that","have","the","potential","to","develop","any","of","several","possible","distinct","developmental","paths","have","their","individual","developmental","fates","determined","in","response","to","genetic","cues","."),4332659). assertion_content_comment('tOboGo_PolyphenicDetermination',s("The","process","in","which","individuals","that","have","the","potential","to","develop","any","of","several","possible","distinct","developmental","paths","have","their","individual","developmental","fates","determined","in","response","to","environmental","and/or","genetic","cues","."),4106646). assertion_content_comment('tOboGo_Polyphosphate_AMPPhosphotransferaseActivity',s("Catalysis","of","the","reaction",":","(","polyphosphate",")","n","+","AMP","=","(","polyphosphate",")","n-1","+","ADP","."),4325982). assertion_content_comment('tOboGo_PolyphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","polyphosphate",",","the","anion","or","salt","of","polyphosphoric","acid","."),4229863). assertion_content_comment('tOboGo_PolyphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","polyphosphate",",","the","anion","or","salt","of","polyphosphoric","acid","."),4229849). assertion_content_comment('tOboGo_PolyphosphateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","phosphate","(","n",")","=","ADP","+","phosphate","(","n","+","1",")"),4247929). assertion_content_comment('tOboGo_PolyphosphateKinaseComplex',s("A","protein","complex","that","possesses","polyphosphate","kinase","activity","."),4260215). assertion_content_comment('tOboGo_PolyphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","polyphosphate",",","the","anion","or","salt","of","polyphosphoric","acid","."),4229845). assertion_content_comment('tOboGo_PolyphosphatidylinositolPhosphataseActivity',s("Catalysis","of","the","conversion","of","phosphatidylinositol-3-phosphate",",","phosphatidylinositol-4-phosphate",",","and","phosphatidylinositol-3",",","5-bisphosphate",",","but","not","PI-4",",","5-bisphosphate",",","to","phosphatidylinositol",";","PPIPase","activity","is","a","key","regulator","of","membrane","trafficking","and","actin","cytoskeleton","organization","."),4267561). assertion_content_comment('tOboGo_PolyprenolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","polyprenols",",","prenols","with","more","than","4","isoprenoid","residues",",","which","may","be","all-trans",",","or","a","mixture","of","cis","and","trans","."),4010072). assertion_content_comment('tOboGo_PolyprenolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","polyprenols",",","prenols","with","more","than","4","isoprenoid","residues",",","which","may","be","all-trans",",","or","a","mixture","of","cis","and","trans","."),4303351). assertion_content_comment('tOboGo_PolyprenolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","polyprenols",",","prenols","with","more","than","4","isoprenoid","residues",",","which","may","be","all-trans",",","or","a","mixture","of","cis","and","trans","."),4010069). assertion_content_comment('tOboGo_PolyprenyldihydroxybenzoateMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","3-polyprenyl-4",",","5-dihydroxybenzoate","=","S-adenosyl-L-homocysteine","+","3-polyprenyl-4-hydroxy-5-methoxybenzoate","+","H","+"),4208112). assertion_content_comment('tOboGo_PolyprenyltransferaseActivity',s("Catalysis","of","the","transfer","of","multiple","prenyl","groups","from","one","compound","(","donor",")","to","another","(","acceptor",")"),4255720). assertion_content_comment('tOboGo_PolyribonucleotideKinaseActivity',s("Catalysis","of","the","reaction",":","NTP","+","5","'","-dephospho-RNA","=","NDP","+","5","'","-phospho-RNA","."),4281052). assertion_content_comment('tOboGo_PolyribonucleotideNucleotidyltransferaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","RNA","(","n",")","=","diphosphate","+","RNA","(","n","+","1",")"),4203312). assertion_content_comment('tOboGo_PolysaccharideAssemblyWithMHCClassIIProteinComplex',s("The","binding","of","a","polysaccharide","to","the","antigen","binding","groove","of","an","MHC","class","II","protein","complex","."),3996134). assertion_content_comment('tOboGo_PolysaccharideBinding',s("Interacting","selectively","and","non-covalently","with","any","polysaccharide",",","a","polymer","of","more","than","20","monosaccharide","residues","joined","by","glycosidic","linkages","."),4157726). assertion_content_comment('tOboGo_PolysaccharideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","polysaccharides",",","polymers","of","more","than","10","monosaccharide","residues","joined","by","glycosidic","linkages","."),4009068). assertion_content_comment('tOboGo_PolysaccharideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","polysaccharides",",","polymers","of","more","than","10","monosaccharide","residues","joined","by","glycosidic","linkages","."),4008831). assertion_content_comment('tOboGo_PolysaccharideDigestion',s("The","whole","of","the","physical",",","chemical",",","and","biochemical","processes","carried","out","by","living","organisms","to","break","down","ingested","polysaccharides","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),4097901). assertion_content_comment('tOboGo_PolysaccharideLocalization',s("Any","process","in","which","a","polysaccharide","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4033634). assertion_content_comment('tOboGo_PolysaccharideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","polysaccharides",",","a","polymer","of","more","than","20","monosaccharide","residues","joined","by","glycosidic","linkages","."),4008712). assertion_content_comment('tOboGo_PolysaccharideReceptorActivity',s("Combining","with","a","polysaccharide","to","initiate","a","change","in","cell","activity","."),4384378). assertion_content_comment('tOboGo_PolysaccharideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","polysaccharides","from","one","side","of","the","membrane","to","the","other",".","A","polysaccharide","is","a","polymer","of","more","than","about","10","monosaccharide","residues","joined","by","glycosidic","linkages","."),4290391). assertion_content_comment('tOboGo_PolysaccharideTransport',s("The","directed","movement","of","polysaccharides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","A","polysaccharide","is","a","polymer","of","more","than","about","10","monosaccharide","residues","joined","by","glycosidic","linkages","."),4033660). assertion_content_comment('tOboGo_PolysomalRibosome',s("A","ribosome","bound","to","mRNA","that","forms","part","of","a","polysome","."),4077386). assertion_content_comment('tOboGo_Polysome',s("Several","ribosomes","bound","to","one","mRNA","."),4077375). assertion_content_comment('tOboGo_PolyteneChromosomeBand',s("A","stretch","of","densely","packed","chromatin","along","the","polytene","chromosome",",","visible","as","a","morphologically","distinct","band","."),4007932). assertion_content_comment('tOboGo_PolyteneChromosomeChromocenter',s("A","region","at","which","the","centric","regions","of","polytene","chromosomes","are","joined","together","."),4007860). assertion_content_comment('tOboGo_PolyteneChromosomeEctopicFiber',s("A","thread-like","connection","joining","two","regions","of","ectopically","paired","polytene","chromosomes","."),4007911). assertion_content_comment('tOboGo_PolyteneChromosomeInterband',s("A","stretch","of","less","tightly","packed","chromatin","along","the","polytene","chromosome",",","found","between","bands","."),4007922). assertion_content_comment('tOboGo_PolyteneChromosomePuffing',s("The","decondensing","(","loosening",")","and","swelling","of","the","chromosomal","sites","of","target","genes","on","polytene","chromosomes","following","response","to","a","stimulus",",","to","facilitate","sudden","bursts","of","transcriptional","activity","in","response","to","transient","environmental","signals","."),4381637). assertion_content_comment('tOboGo_PolyteneChromosomePuff',s("A","swelling","at","a","site","along","the","length","of","a","polytene","chromosome",",","thought","to","be","the","site","of","active","transcription","."),4007942). assertion_content_comment('tOboGo_PolyteneChromosome',s("A","type","of","chromosome","in","a","polyploid","cell",",","formed","when","multiple","copies","of","homologous","chromosomes","are","aligned","side","by","side","to","give","a","giant","chromosome","in","which","distinct","chromosome","bands","are","readily","visible","."),4007858). assertion_content_comment('tOboGo_PolyteneChromosomeTelomericRegion',s("The","terminal","region","of","a","polytene","chromosome","."),4072473). assertion_content_comment('tOboGo_PolyteneChromosomeWeakPoint',s("A","region","of","the","polytene","chromosome","where","the","diameter","is","considerably","decreased",",","probably","resulting","from","local","differences","in","chromosome","organization","."),4007952). assertion_content_comment('tOboGo_PolyterpenoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","polyterpenoid","compounds",",","terpenoids","with","more","than","eight","isoprene","units","."),4303302). assertion_content_comment('tOboGo_PolyterpenoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","polyterpenoid","compounds",",","terpenoids","with","more","than","eight","isoprene","units","."),4303319). assertion_content_comment('tOboGo_PolyterpenoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","polyterpenoid","compounds",",","terpenoids","with","more","than","eight","isoprene","units","."),4303296). assertion_content_comment('tOboGo_PolythionateOxidation',s("The","chemical","reactions","and","pathways","resulting","in","the","conversion","of","thiosulfate","to","tetrathionate",",","using","cytochrome","c","as","an","electron","acceptor","."),4240725). assertion_content_comment('tOboGo_PolyubiquitinatedMisfoldedProteinTransport',s("The","directed","movement","of","misfolded","polyubiquitinated","proteins","in","a","cell",",","including","the","movement","of","proteins","between","specific","compartments","or","structures","within","a","cell","."),4178764). assertion_content_comment('tOboGo_PolyubiquitinatedProteinTransport',s("The","directed","movement","of","polyubiquitinated","proteins","in","a","cell",",","including","the","movement","of","proteins","between","specific","compartments","or","structures","within","a","cell","."),4178744). assertion_content_comment('tOboGo_PolyubiquitinBinding',s("Interacting","selectively","and","non-covalently","with","a","polymer","of","ubiqutin","."),4169404). assertion_content_comment('tOboGo_Polyubiquitin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218189). assertion_content_comment('tOboGo_PolyURNABinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","uracil","residues","in","an","RNA","molecule","."),4256127). assertion_content_comment('tOboGo_PonsDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pons","over","time",",","from","its","formation","to","the","mature","structure",".","The","pons","lies","above","the","medulla","and","next","to","the","cerebellum",".","The","pons","conveys","information","about","movement","from","the","cerebral","hemisphere","to","the","cerebellum","."),4042465). assertion_content_comment('tOboGo_PonsFormation',s("The","process","that","gives","rise","to","the","pons",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","pons","lies","above","the","medulla","and","next","to","the","cerebellum",".","The","pons","conveys","information","about","movement","from","the","cerebral","hemisphere","to","the","cerebellum","."),4042946). assertion_content_comment('tOboGo_PonsMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","pons","to","attain","its","fully","functional","state",".","The","pons","lies","above","the","medulla","and","next","to","the","cerebellum",".","The","pons","conveys","information","about","movement","from","the","cerebral","hemisphere","to","the","cerebellum","."),4042684). assertion_content_comment('tOboGo_PonsMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","pons","is","generated","and","organized",".","The","pons","lies","above","the","medulla","and","next","to","the","cerebellum",".","The","pons","conveys","information","about","movement","from","the","cerebral","hemisphere","to","the","cerebellum","."),4042911). assertion_content_comment('tOboGo_PonsReticulospinalTractMorphogenesis',s("Generation","of","a","long","process","of","a","CNS","neuron",",","that","carries","efferent","(","outgoing",")","action","potentials","from","the","cell","body","in","the","pons","towards","target","cells","in","the","spinal","cord","."),4048119). assertion_content_comment('tOboGo_PonsStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","pons",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","pons","lies","above","the","medulla","and","next","to","the","cerebellum",".","The","pons","conveys","information","about","movement","from","the","cerebral","hemisphere","to","the","cerebellum","."),4043301). assertion_content_comment('tOboGo_PoreComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","pore","complex",".","A","pore","complex","is","a","small","opening","in","a","membrane","that","allows","the","passage","of","liquids","and/or","gases","."),4012900). assertion_content_comment('tOboGo_PoreComplex',s("Any","small","opening","in","a","membrane","that","allows","the","passage","of","gases","and/or","liquids","."),4006538). assertion_content_comment('tOboGo_PorinActivity',s("Catalysis","of","the","transfer","of","substances",",","sized","less","than","1000","Da",",","from","one","side","of","the","membrane","to","the","other",".","The","transmembrane","portions","of","porins","consist","exclusively","of","beta-strands","which","form","a","beta-barrel",".","They","are","found","in","the","outer","membranes","of","Gram-negative","bacteria",",","mitochondria",",","plastids","and","possibly","acid-fast","Gram-positive","bacteria","."),4292345). assertion_content_comment('tOboGo_Porosome',s("A","permanent","cup-shaped","structure","at","the","cell","plasma","membrane","in","secretory","cells",".","Following","a","secretory","stimulus",",","secretory","vesicles","transiently","dock","and","fuse","at","the","base","of","porosomes","and","release","intravesicular","contents","dictated","by","the","turgor","pressure","generated","from","the","swelling","of","secretory","vesicles","."),4347563). assertion_content_comment('tOboGo_PorousCellSeptum',s("A","septum","or","cross","wall","which","does","not","entirely","span","the","space","between","two","portions","of","cell","wall","and","may","contain","a","specialized","central","pore","structure",".","A","porous","septum","allows","the","movement","of","organelles","and/or","cytoplasm","between","compartments","."),4363183). assertion_content_comment('tOboGo_PorphobilinogenSynthaseActivity',s("Catalysis","of","the","reaction",":","2","5-aminolevulinate","=","2","H","(","2",")","O","+","H","(","+",")","+","porphobilinogen","."),4203293). assertion_content_comment('tOboGo_PorphyrinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","member","of","a","large","group","of","derivatives","or","analogs","of","porphyrin",".","Porphyrin","consists","of","a","ring","of","four","pyrrole","nuclei","linked","each","to","the","next","at","their","alpha","positions","through","a","methine","group","."),4014405). assertion_content_comment('tOboGo_PorphyrinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","member","of","a","large","group","of","derivatives","or","analogs","of","porphyrin",".","Porphyrin","consists","of","a","ring","of","four","pyrrole","nuclei","linked","each","to","the","next","at","their","alpha","positions","through","a","methine","group","."),4014652). assertion_content_comment('tOboGo_PorphyrinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","member","of","a","large","group","of","derivatives","or","analogs","of","porphyrin",".","Porphyrins","consists","of","a","ring","of","four","pyrrole","nuclei","linked","each","to","the","next","at","their","alpha","positions","through","a","methine","group","."),4014370). assertion_content_comment('tOboGo_PositiveAdaptationOfSignalingPathway',s("The","positive","regulation","of","a","signal","transduction","pathway","in","response","to","a","stimulus","upon","prolonged","exposure","to","that","stimulus","."),4346950). assertion_content_comment('tOboGo_PositiveAerotaxisInEnvironmentOfOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","environmental","oxygen","on",",","within","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4197524). assertion_content_comment('tOboGo_PositiveAerotaxisInHostEnvironment',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","environmental","oxygen","on",",","within","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197528). assertion_content_comment('tOboGo_PositiveAerotaxisInHost',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","environmental","oxygen","within","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197584). assertion_content_comment('tOboGo_PositiveAerotaxisInOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","environmental","oxygen","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4197580). assertion_content_comment('tOboGo_PositiveAerotaxisOnOrNearHost',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","environmental","oxygen","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197613). assertion_content_comment('tOboGo_PositiveAerotaxisOnOrNearOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","environmental","oxygen","on","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4197610). assertion_content_comment('tOboGo_PositiveAerotaxis',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","environmental","oxygen","."),4197519). assertion_content_comment('tOboGo_PositiveChemotaxisInEnvironmentOfOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","a","chemical","on",",","within","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196626). assertion_content_comment('tOboGo_PositiveChemotaxisInHostEnvironment',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","a","chemical","on",",","within","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197381). assertion_content_comment('tOboGo_PositiveChemotaxisInHost',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","a","specific","chemical","within","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197398). assertion_content_comment('tOboGo_PositiveChemotaxisInOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","a","specific","chemical","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196668). assertion_content_comment('tOboGo_PositiveChemotaxisOnOrNearHost',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","a","specific","chemical","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197386). assertion_content_comment('tOboGo_PositiveChemotaxisOnOrNearOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","a","specific","chemical","on","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196643). assertion_content_comment('tOboGo_PositiveChemotaxis',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","a","chemical","."),4031754). assertion_content_comment('tOboGo_PositiveEnergyTaxisInEnvironmentOfOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","on",",","within","or","near","a","second","organism","towards","a","higher","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196927). assertion_content_comment('tOboGo_PositiveEnergyTaxisInHostEnvironment',s("The","directed","movement","of","a","motile","cell","or","organism","on",",","within","or","near","its","host","organism","towards","a","higher","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197259). assertion_content_comment('tOboGo_PositiveEnergyTaxisInHost',s("The","directed","movement","of","a","motile","cell","or","organism","within","its","host","organism","towards","a","higher","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197488). assertion_content_comment('tOboGo_PositiveEnergyTaxisInOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","within","a","second","organism","towards","a","higher","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196944). assertion_content_comment('tOboGo_PositiveEnergyTaxisOnOrNearHost',s("The","directed","movement","of","a","motile","cell","or","organism","on","or","near","its","host","organism","towards","a","higher","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197276). assertion_content_comment('tOboGo_PositiveEnergyTaxisOnOrNearOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","on","or","near","a","second","organism","towards","a","higher","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196932). assertion_content_comment('tOboGo_PositiveEnergyTaxis',s("The","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","level","of","a","physical","stimulus","involved","in","energy","generation",",","such","as","light",",","oxygen",",","and","oxidizable","substrates","."),4196924). assertion_content_comment('tOboGo_PositiveExtrathymicTCellSelection',s("The","process","of","sparing","extrathymically","maturing","T","cells","which","react","with","self-MHC","protein","complexes","with","low","affinity","levels","from","apoptotic","death","."),4300996). assertion_content_comment('tOboGo_PositiveGravitaxis',s("The","directed","movement","of","a","motile","cell","or","organism","towards","the","source","of","gravity","."),4384640). assertion_content_comment('tOboGo_PositiveGravitropism',s("The","orientation","of","plant","parts","towards","gravity","."),4262117). assertion_content_comment('tOboGo_PositivePhototaxis',s("The","directed","movement","of","a","cell","or","organism","towards","a","source","of","light","."),4361958). assertion_content_comment('tOboGo_PositiveRegulationByHostOfCytolysisOfSymbiontCells',s("Any","process","in","which","an","organism","activates","or","increases","the","frequency",",","rate","or","extent","of","cytolysis","by","that","organism","of","cells","in","its","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282352). assertion_content_comment('tOboGo_PositiveRegulationByHostOfNutrientReleaseFromSymbiont',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","release","of","nutrients","from","a","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4185625). assertion_content_comment('tOboGo_PositiveRegulationByHostOfSymbiontAdenylateCyclaseActivity',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","adenylate","cyclase","activity",",","which","catalyze","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154317). assertion_content_comment('tOboGo_PositiveRegulationByHostOfSymbiontCatalyticActivity',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","enzyme","activity",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154307). assertion_content_comment('tOboGo_PositiveRegulationByHostOfSymbiontDefenseResponse',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","defense","response","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190768). assertion_content_comment('tOboGo_PositiveRegulationByHostOfSymbiontPhagocytosis',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","phagocytosis",",","the","engulfing","by","phagocytes","of","external","particulate","material",",","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186161). assertion_content_comment('tOboGo_PositiveRegulationByHostOfSymbiontSignalTransductionPathway',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153256). assertion_content_comment('tOboGo_PositiveRegulationByHostOfViralTranscription',s("Any","process","is","which","a","host","organism","activates","or","increases","the","frequency",",","rate","or","extent","of","viral","transcription",",","the","synthesis","of","either","RNA","on","a","template","of","DNA","or","DNA","on","a","template","of","RNA","."),4328047). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfApoptosisInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death","by","apoptosis","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184171). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfBloodCoagulationInOtherOrganism',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","blood","coagulation","in","another","organism",".","Blood","coagulation","is","the","sequential","process","in","which","the","multiple","coagulation","factors","of","the","blood","interact",",","ultimately","resulting","in","the","formation","of","an","insoluble","fibrin","clot","."),4370467). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfDefenseResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4121188). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfEntryIntoOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","to","which","it","enters","into","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4146083). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfHormoneOrGrowthRegulatorLevelsInOtherOrganismInvolvedInSymbioticInteraction',s("The","increase","by","an","organism","of","the","levels","of","hormones","or","growth","regulators","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4185698). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfHormoneOrGrowthRegulatorLevelsInSymbiont',s("OBSOLETE",".","The","increase","by","an","organism","of","the","levels","of","hormones","or","growth","regulators","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4185715). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfImmuneResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","immune","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction",".","The","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat","."),4184885). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfInducedSystemicResistanceInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","induced","systemic","resistance",",","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184977). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfInducedSystemicResistanceInSymbiont',s("OBSOLETE",".","Any","process","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","induced","systemic","resistance","in","the","symbiont","organism",";","induced","systemic","resistance","is","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4184918). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfInflammatoryResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","inflammatory","response",",","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",",","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195169). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfInnateImmunityInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184893). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfNutrientReleaseFromOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","release","of","nutrients","from","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4185439). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfPhagocytosisInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","phagocytosis",",","the","engulfing","by","phagocytes","of","external","particulate","material",",","in","the","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4186135). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfPhytoalexinProductionInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","production","of","phytoalexins","that","occurs","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195771). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfProgrammedCellDeathInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4110236). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSignalTransductionPathwayInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","second","organism","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4152661). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSymbiontApoptosis',s("OBSOLETE",".","Any","process","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","symbiont",",","where","programmed","cell","death","proceeds","by","apoptosis",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4184232). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSymbiontImmuneResponse',s("OBSOLETE",".","Any","process","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","immune","response","of","the","symbiont","organism",";","the","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186975). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSymbiontInflammatoryResponse',s("OBSOLETE",".","Any","process","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","inflammatory","response","of","a","symbiont","organism",";","the","inflammatory","response","is","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4185688). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSymbiontInnateImmunity',s("OBSOLETE",".","Any","process","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","the","symbiont","organism",";","the","innate","immune","response","is","the","symbiont","'","s","first","line","of","defense","against","infection",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4185677). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSymbiontPhytoalexinProduction',s("OBSOLETE",".","Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","production","of","phytoalexins","as","part","of","the","defense","response","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197129). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSymbiontProgrammedCellDeath',s("OBSOLETE",".","Any","process","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186189). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSystemicAcquiredResistanceInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","systemic","acquired","resistance","organism",";","systemic","acquired","resistance","is","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184902). assertion_content_comment('tOboGo_PositiveRegulationByOrganismOfSystemicAcquiredResistanceInSymbiont',s("OBSOLETE",".","Any","process","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","systemic","acquired","resistance","in","the","symbiont","organism",";","systemic","acquired","resistance","is","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4185110). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfEntryIntoHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","to","which","it","enters","into","the","host","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4146090). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHormoneOrGrowthRegulatorLevelsInHost',s("The","increase","by","an","organism","of","the","levels","of","hormones","or","growth","regulators","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194879). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostAdenylateCyclaseActivity',s("Any","process","in","which","the","symbiont","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","host","adenylate","cyclase","activity",",","which","involves","catalysis","of","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153220). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostApoptosis',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","host",",","where","programmed","cell","death","proceeds","by","apoptosis",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195230). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostCatalyticActivity',s("Any","process","in","which","the","symbiont","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","host","enzyme","activity",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153162). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostDefenseResponse',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","defense","response","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121217). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostImmuneResponse',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","immune","response","of","the","host","organism",";","the","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4184995). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostInducedSystemicResistance',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","induced","systemic","resistance","in","the","host","organism",";","induced","systemic","resistance","is","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4185002). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostInflammatoryResponse',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","inflammatory","response","of","the","host","organism",";","the","inflammatory","response","is","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195178). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostInnateImmunity',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","the","host","organism",";","the","innate","immune","response","is","the","host","'","s","first","line","of","defense","against","infection",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190574). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostPhagocytosis',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","phagocytosis",",","the","engulfing","by","phagocytes","of","external","particulate","material",",","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195643). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostPhytoalexinProduction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","production","of","phytoalexins","as","part","of","the","defense","response","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195807). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostProgrammedCellDeath',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121142). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostSignalTransductionPathway',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","host","signal","transduction","pathways",",","the","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152669). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostSystemicAcquiredResistance',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","systemic","acquired","resistance","in","the","host","organism",";","systemic","acquired","resistance","is","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4185094). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfHostVacuoleOrganization',s("The","process","in","which","a","symbiont","organism","activates","or","increases","the","frequency",",","rate","or","extent","of","vacuole","organization","in","its","host","organism","."),4288656). assertion_content_comment('tOboGo_PositiveRegulationBySymbiontOfNutrientReleaseFromHost',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","release","of","nutrients","from","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194671). assertion_content_comment('tOboGo_PositiveRegulationOfAbscisicAcidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","abscisic","acid","."),4032967). assertion_content_comment('tOboGo_PositiveRegulationOfAbscisicAcidMediatedSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","abscisic","acid","mediated","signal","transduction","."),4022585). assertion_content_comment('tOboGo_PositiveRegulationOfAcetateCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate","."),4086618). assertion_content_comment('tOboGo_PositiveRegulationOfAcetylcholineMetabolicProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","involving","acetylcholine",",","the","acetic","acid","ester","of","the","organic","base","choline",".","Acetylcholine","is","a","major","neurotransmitter","and","neuromodulator","both","in","the","central","and","peripheral","nervous","systems",".","It","also","acts","as","a","paracrine","signal","in","various","non-neural","tissues","."),4117479). assertion_content_comment('tOboGo_PositiveRegulationOfAcetylcholineSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","acetylcholine","."),4039378). assertion_content_comment('tOboGo_PositiveRegulationOfAcetylcholineUptake',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","acetylcholine","into","a","cell","."),4121584). assertion_content_comment('tOboGo_PositiveRegulationOfAcrosomalVesicleExocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","acrosomal","vesicle","exocytosis","."),4142943). assertion_content_comment('tOboGo_PositiveRegulationOfAcrosomeReaction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","acrosome","reaction","."),4143355). assertion_content_comment('tOboGo_PositiveRegulationOfActinCytoskeletonReorganization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","actin","cytoskeleton","reorganization","."),4140424). assertion_content_comment('tOboGo_PositiveRegulationOfActinFilamentBundleAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","assembly","of","actin","filament","bundles","."),4054469). assertion_content_comment('tOboGo_PositiveRegulationOfActinFilamentDepolymerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","actin","depolymerization","."),4051284). assertion_content_comment('tOboGo_PositiveRegulationOfActinFilamentPolymerizationInvolvedInAcrosomeReaction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","actin","polymerization","as","part","of","the","acrosome","reaction","."),4117883). assertion_content_comment('tOboGo_PositiveRegulationOfActinFilamentPolymerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","actin","polymerization","."),4051520). assertion_content_comment('tOboGo_PositiveRegulationOfActinNucleation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","actin","nucleation",",","the","initial","step","in","the","formation","of","an","actin","filament","in","which","actin","monomers","combine","to","form","a","new","filament","."),4119354). assertion_content_comment('tOboGo_PositiveRegulationOfActinPolymerizationAndOrDepolymerization',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","actin","polymerization","and/or","depolymerization","."),4297822). assertion_content_comment('tOboGo_PositiveRegulationOfActionPotential',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","action","potential","creation",",","propagation","or","termination",".","An","action","potential","is","a","spike","of","membrane","depolarization","and","repolarization","that","travels","along","the","membrane","of","a","cell","."),4297831). assertion_content_comment('tOboGo_PositiveRegulationOfActivatedTCellAutonomousCellDeath',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lymphocyte","death","by","apoptosis","."),4137545). assertion_content_comment('tOboGo_PositiveRegulationOfActivatedTCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","activated","T","cell","proliferation","."),4080956). assertion_content_comment('tOboGo_PositiveRegulationOfActivationOfJAK1KinaseActivity',s("Any","process","that","increases","the","frequency","or","rate","of","activation","of","JAK1","protein",".","The","activation","of","JAK1","protein","is","the","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK1","(","Janus","Activated","Kinase","1",")","protein",",","thereby","activating","it","."),4027187). assertion_content_comment('tOboGo_PositiveRegulationOfActivationOfJAK2KinaseActivity',s("Any","process","that","increase","the","frequency","or","rate","of","activation","of","JAK2","protein",".","The","activation","of","JAK2","protein","is","the","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK2","(","Janus","Activated","Kinase","2",")","protein",",","thereby","activating","it","."),4027313). assertion_content_comment('tOboGo_PositiveRegulationOfActivationOfJanusKinaseActivity',s("Any","process","that","increases","the","frequency","or","rate","of","activation","of","JAK","protein",".","The","activation","of","JAK","protein","is","the","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK","(","Janus","Activated","Kinase",")","protein",",","thereby","activating","it","."),4027182). assertion_content_comment('tOboGo_PositiveRegulationOfActivationOfMembraneAttackComplex',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","activation","of","the","membrane","attack","complex","components","of","the","complement","cascade","."),3987634). assertion_content_comment('tOboGo_PositiveRegulationOfActivinReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","activity","of","any","activin","receptor","signaling","pathway","."),4064201). assertion_content_comment('tOboGo_PositiveRegulationOfActivinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","activin","from","a","cell","or","group","of","cells","."),4056165). assertion_content_comment('tOboGo_PositiveRegulationOfAcuteInflammatoryResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","acute","inflammatory","response","."),3983496). assertion_content_comment('tOboGo_PositiveRegulationOfAcuteInflammatoryResponseToAntigenicStimulus',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","acute","inflammatory","response","to","an","antigenic","stimulus","."),3983554). assertion_content_comment('tOboGo_PositiveRegulationOfAdaptiveImmuneResponseBasedOnSomaticRecombinationOfImmuneReceptorsBuiltFromImmunoglobulinSuperfamilyDomains',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","adaptive","immune","response","based","on","somatic","recombination","of","immune","receptors","built","from","immunoglobulin","superfamily","domains",".","An","example","of","this","process","is","found","in","the","Gnathostomata","."),3983662). assertion_content_comment('tOboGo_PositiveRegulationOfAdaptiveImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","adaptive","immune","response","."),3983653). assertion_content_comment('tOboGo_PositiveRegulationOfAdenosineReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","adenosine","receptor","signaling","pathway",".","The","adenosine","receptor","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","an","adenosine","receptor","binding","to","one","of","its","physiological","ligands","."),4108498). assertion_content_comment('tOboGo_PositiveRegulationOfAdenosineTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","adenosine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053940). assertion_content_comment('tOboGo_PositiveRegulationOfAdenylateCyclaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","adenylate","cyclase","activity","."),4153211). assertion_content_comment('tOboGo_PositiveRegulationOfAdiponectinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","adiponectin","from","a","cell","or","group","of","cells","."),4133424). assertion_content_comment('tOboGo_PositiveRegulationOfAdrenergicReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","adrenergic","receptor","protein","signaling","pathway",".","An","adrenergic","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","an","adrenergic","receptor","binding","to","one","of","its","physiological","ligands","."),4125526). assertion_content_comment('tOboGo_PositiveRegulationOfAdultSalivaryGlandBoundarySpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","salivary","gland","determination","in","an","adult","organism","."),4091343). assertion_content_comment('tOboGo_PositiveRegulationOfAeciosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","aeciospore","formation",",","a","process","in","which","a","dikaryotic","spore","of","typically","a","rust","fungus","is","produced","in","an","aecium","."),4148615). assertion_content_comment('tOboGo_PositiveRegulationOfAeciumDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","aecium","development",",","a","process","in","which","a","cuplike","structure","containing","chains","of","aeciospores","is","formed","."),4148435). assertion_content_comment('tOboGo_PositiveRegulationOfAggregateSizeInvolvedInSorocarpDevelopment',s("Any","process","that","increases","the","size","of","the","aggregate","formed","during","sorocarp","formation","."),4318921). assertion_content_comment('tOboGo_PositiveRegulationOfAldosteroneBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","aldosterone","."),4056076). assertion_content_comment('tOboGo_PositiveRegulationOfAldosteroneMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","aldosterone","."),4056043). assertion_content_comment('tOboGo_PositiveRegulationOfAlkalinePhosphataseActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","alkaline","phosphatase","activity",",","the","catalysis","of","the","reaction",":","an","orthophosphoric","monoester","+","H2O","=","an","alcohol","+","phosphate",",","with","an","alkaline","pH","optimum","."),4336509). assertion_content_comment('tOboGo_PositiveRegulationOfAmineTransport',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amines","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990848). assertion_content_comment('tOboGo_PositiveRegulationOfAminoAcidTransport',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amino","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990857). assertion_content_comment('tOboGo_PositiveRegulationOfAminoAcidUptakeInvolvedInSynapticTransmission',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amino","acid","neurotransmitters","into","a","neuron","or","glial","cell","."),4120440). assertion_content_comment('tOboGo_PositiveRegulationOfAmyloidPrecursorProteinBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","amyloid","precursor","protein","(","APP",")",",","the","precursor","of","beta-amyloid","."),4093760). assertion_content_comment('tOboGo_PositiveRegulationOfAnagen',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","anagen",",","the","growth","phase","of","the","hair","cycle","."),4122514). assertion_content_comment('tOboGo_PositiveRegulationOfAngiogenesis',s("Any","process","that","activates","or","increases","angiogenesis","."),4084535). assertion_content_comment('tOboGo_PositiveRegulationOfAnoikis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","anoikis","."),4141112). assertion_content_comment('tOboGo_PositiveRegulationOfAnthocyaninBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","anthocyanins","."),4060624). assertion_content_comment('tOboGo_PositiveRegulationOfAnthocyaninMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","involving","anthocyanins","."),4060590). assertion_content_comment('tOboGo_PositiveRegulationOfAntibacterialPeptideBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","biosynthesis","."),4011307). assertion_content_comment('tOboGo_PositiveRegulationOfAntibacterialPeptideProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","production","."),3997537). assertion_content_comment('tOboGo_PositiveRegulationOfAntibacterialPeptideSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","secretion","."),3997647). assertion_content_comment('tOboGo_PositiveRegulationOfAntifungalPeptideBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","biosynthesis","."),4011289). assertion_content_comment('tOboGo_PositiveRegulationOfAntifungalPeptideProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","production","."),3997553). assertion_content_comment('tOboGo_PositiveRegulationOfAntifungalPeptideSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","secretion","."),3997699). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentationOfLipidAntigenViaMHCClassIb',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","lipid","antigen","via","MHC","class","Ib","."),3994950). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentationOfPeptideAntigen',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","."),3994985). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassIb',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","Ib","."),3995008). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassII',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","II","."),3996158). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassI',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","I","."),3995095). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentationOfPeptideOrPolysaccharideAntigenViaMHCClassII',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","antigen","(","peptide","or","polysaccharide",")","via","MHC","class","II","."),3994812). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentationOfPolysaccharideAntigenViaMHCClassII',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","polysaccharide","antigen","via","MHC","class","II","."),3994833). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","."),3994423). assertion_content_comment('tOboGo_PositiveRegulationOfAntigenProcessingAndPresentationViaMHCClassIb',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","antigen","via","MHC","class","Ib","."),3994941). assertion_content_comment('tOboGo_PositiveRegulationOfAntimicrobialHumoralResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","antimicrobial","humoral","response","."),3996768). assertion_content_comment('tOboGo_PositiveRegulationOfAntimicrobialPeptideBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","biosynthesis","."),4000904). assertion_content_comment('tOboGo_PositiveRegulationOfAntimicrobialPeptideProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","production","."),3993359). assertion_content_comment('tOboGo_PositiveRegulationOfAntimicrobialPeptideSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","secretion","."),3997429). assertion_content_comment('tOboGo_PositiveRegulationOfAntipodalCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","antipodal","cell","differentiation","."),4091543). assertion_content_comment('tOboGo_PositiveRegulationOfAntisenseRNATranscription',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","synthesis","of","antisense","RNA",",","an","RNA","molecule","complementary","in","sequence","to","another","RNA","or","DNA","molecule",",","which",",","by","binding","the","latter",",","acts","to","inhibit","its","function","and/or","completion","of","synthesis",",","on","a","template","of","DNA","."),4115596). assertion_content_comment('tOboGo_PositiveRegulationOfAntralOvarianFollicleGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","antral","ovarian","follicle","growth","."),4142585). assertion_content_comment('tOboGo_PositiveRegulationOfAplanosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","aplanospore","formation",",","a","process","in","which","a","nonmotile",",","asexual","spore","is","formed","within","a","cell","in","certain","algae","and","fungi","(","commonly","in","the","Phycomycetes",")",",","the","wall","of","aplanospore","is","distinct","from","that","of","the","parent","cell","."),4148281). assertion_content_comment('tOboGo_PositiveRegulationOfApoptosisByVirus',s("Any","viral","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","death","by","apoptosis","."),4108129). assertion_content_comment('tOboGo_PositiveRegulationOfApoptosisInvolvedInMammaryGlandInvolution',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","death","by","apoptosis","of","mammary","epithelial","cells","during","mammary","gland","involution","."),4109285). assertion_content_comment('tOboGo_PositiveRegulationOfApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","death","by","apoptosis","."),3983103). assertion_content_comment('tOboGo_PositiveRegulationOfApoptoticCellClearance',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","apoptotic","cell","clearance","."),4141778). assertion_content_comment('tOboGo_PositiveRegulationOfAppetite',s("Any","process","that","increases","appetite","."),4328957). assertion_content_comment('tOboGo_PositiveRegulationOfAppressoriumFormationOnOrNearHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","symbiont","appressorium","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147047). assertion_content_comment('tOboGo_PositiveRegulationOfAppressoriumInitiationOnOrNearHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","symbiont","appressorium","initiation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147451). assertion_content_comment('tOboGo_PositiveRegulationOfAppressoriumMaturationOnOrNearHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","symbiont","appressorium","maturation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147124). assertion_content_comment('tOboGo_PositiveRegulationOfArachidonicAcidSecretion',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","arachidonic","acid","secretion",",","the","controlled","release","of","arachidonic","acid","from","a","cell","or","group","of","cells","."),4151576). assertion_content_comment('tOboGo_PositiveRegulationOfArbusculeFormationForNutrientAcquisitionFromHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","symbiont","arbuscule","formation","for","nutrient","acquisition","from","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4148898). assertion_content_comment('tOboGo_PositiveRegulationOfARFGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","the","GTPase","ARF","."),4337224). assertion_content_comment('tOboGo_PositiveRegulationOfARFProteinSignalTransduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ARF","protein","signal","transduction","."),4057031). assertion_content_comment('tOboGo_PositiveRegulationOfAscosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","ascospore","formation",",","a","process","in","which","a","sexual","spore",",","named","ascospore",",","from","Ascomycete","fungi","was","produced","inside","an","ascus","."),4148199). assertion_content_comment('tOboGo_PositiveRegulationOfAscusDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","ascus","development",",","a","saclike","structure","produced","by","fungi","of","the","phylum","Ascomycota","(","sac","fungi",")","in","which","sexually","produced","spores","(","ascospores",")",",","usually","four","or","eight","in","number",",","are","formed","."),4147942). assertion_content_comment('tOboGo_PositiveRegulationOfAsexualSporulationResultingInFormationOfACellularSpore',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","formation","of","a","cellular","spore","derived","from","the","products","of","mitosis","."),4096517). assertion_content_comment('tOboGo_PositiveRegulationOfAstrocyteChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","astrocyte","chemotaxis","."),4142429). assertion_content_comment('tOboGo_PositiveRegulationOfAstrocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","astrocyte","differentiation","."),4107247). assertion_content_comment('tOboGo_PositiveRegulationOfAsymmetricCellDivision',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","asymmetric","cell","division","."),4090873). assertion_content_comment('tOboGo_PositiveRegulationOfATPaseActivity',s("Any","process","that","activates","or","increases","the","rate","of","ATP","hydrolysis","by","an","ATPase","."),4337599). assertion_content_comment('tOboGo_PositiveRegulationOfAtrichoblastFateSpecification',s("Any","process","that","induces","or","promotes","atrichoblast","fate","specification","."),4032732). assertion_content_comment('tOboGo_PositiveRegulationOfAttachmentOfSpindleMicrotubulesToKinetochore',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","attachment","of","spindle","microtubules","to","the","kinetochore","."),4120769). assertion_content_comment('tOboGo_PositiveRegulationOfAuditoryReceptorCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","auditory","hair","cell","differentiation","."),4087121). assertion_content_comment('tOboGo_PositiveRegulationOfAutophagicVacuoleSize',s("Any","process","that","increases","autophagic","vacuole","size","."),4297845). assertion_content_comment('tOboGo_PositiveRegulationOfAutophagy',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","autophagy",".","Autophagy","is","the","process","in","which","cells","digest","parts","of","their","own","cytoplasm","."),4030505). assertion_content_comment('tOboGo_PositiveRegulationOfAuxinBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","auxins",",","plant","hormones","that","regulate","aspects","of","plant","growth","."),4028069). assertion_content_comment('tOboGo_PositiveRegulationOfAuxinMediatedSignalingPathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","auxin","mediated","signaling","pathway",".","Auxin","mediated","signaling","pathway","is","the","series","of","molecular","signals","generated","in","response","to","detection","of","auxin","."),4034770). assertion_content_comment('tOboGo_PositiveRegulationOfAuxinMetabolicProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","auxins",",","plant","hormones","that","regulate","aspects","of","plant","growth","."),4028065). assertion_content_comment('tOboGo_PositiveRegulationOfAxialMesodermalCellFateDetermination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","axial","mesoderm","cell","fate","determination","."),4102922). assertion_content_comment('tOboGo_PositiveRegulationOfAxialMesodermalCellFateSpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","axial","mesoderm","cell","fate","specification","."),4102844). assertion_content_comment('tOboGo_PositiveRegulationOfAxonExtensionInvolvedInAxonGuidance',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","axon","extension","involved","in","axon","guidance","."),4105512). assertion_content_comment('tOboGo_PositiveRegulationOfAxonExtensionInvolvedInRegeneration',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","axon","extension","involved","in","regeneration","."),4107067). assertion_content_comment('tOboGo_PositiveRegulationOfAxonExtension',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","axon","extension","."),4090802). assertion_content_comment('tOboGo_PositiveRegulationOfAxonogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","axonogenesis","."),4090794). assertion_content_comment('tOboGo_PositiveRegulationOfAxonRegeneration',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","axon","regeneration","."),4106770). assertion_content_comment('tOboGo_PositiveRegulationOfBarrierSeptumFormation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","barrier","septum","formation",".","Barrier","septum","formation","is","the","assembly","and","arrangement","of","a","septum","that","spans","the","plasma","membrane","interface","between","progeny","cells","following","cytokinesis","."),4035495). assertion_content_comment('tOboGo_PositiveRegulationOfBasidiosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","frequency",",","rate","or","extent","of","basidiospore","formation",",","a","process","in","which","a","sexually","produced","fungal","spore","is","formed","on","a","basidium","in","the","fungi","basidiomycetes","."),4148125). assertion_content_comment('tOboGo_PositiveRegulationOfBasidiumDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","basidium","development",",","a","process","that","leads","to","the","formation","of","basidium",",","a","small",",","specialized","club-shaped","structure","typically","bearing","four","basidiospores","at","the","tips","of","minute","projections",".","The","basidium","is","unique","to","basidiomycetes","and","distinguishes","them","from","other","kinds","of","fungi","."),4148028). assertion_content_comment('tOboGo_PositiveRegulationOfBasophilDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","basophil","differentiation","."),4087595). assertion_content_comment('tOboGo_PositiveRegulationOfBCellActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","B","cell","activation","."),3989237). assertion_content_comment('tOboGo_PositiveRegulationOfBCellAnergy',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","B","cell","anergy","."),3998376). assertion_content_comment('tOboGo_PositiveRegulationOfBCellAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","B","cell","antigen","processing","and","presentation","."),3994446). assertion_content_comment('tOboGo_PositiveRegulationOfBCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","B","cell","apoptosis","."),3999408). assertion_content_comment('tOboGo_PositiveRegulationOfBCellChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","B","cell","chemotaxis","."),4145141). assertion_content_comment('tOboGo_PositiveRegulationOfBCellCytokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","B","cell","cytokine","production","."),3998527). assertion_content_comment('tOboGo_PositiveRegulationOfBCellDeletion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","B","cell","deletion","."),3999416). assertion_content_comment('tOboGo_PositiveRegulationOfBCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","B","cell","differentiation","."),3989248). assertion_content_comment('tOboGo_PositiveRegulationOfBCellMediatedImmunity',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","B","cell","mediated","immunity","."),3983665). assertion_content_comment('tOboGo_PositiveRegulationOfBCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","B","cell","proliferation","."),4062036). assertion_content_comment('tOboGo_PositiveRegulationOfBCellReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","pathways","initiated","by","the","cross-linking","of","an","antigen","receptor","on","a","B","cell","."),4100929). assertion_content_comment('tOboGo_PositiveRegulationOfBCellToleranceInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","B","cell","tolerance","induction","."),3995177). assertion_content_comment('tOboGo_PositiveRegulationOfBehavior',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","behavior",",","the","specific","actions","or","reactions","of","an","organism","in","response","to","external","or","internal","stimuli","."),3998200). assertion_content_comment('tOboGo_PositiveRegulationOfBeta2IntegrinBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta","2","integrins","."),4090763). assertion_content_comment('tOboGo_PositiveRegulationOfBicoidMRNALocalization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","process","in","which","bicoid","mRNA","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4090225). assertion_content_comment('tOboGo_PositiveRegulationOfBileAcidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","bile","acids","."),4132284). assertion_content_comment('tOboGo_PositiveRegulationOfBinding',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","binding",",","the","selective","interaction","of","a","molecule","with","one","or","more","specific","sites","on","another","molecule","."),4154995). assertion_content_comment('tOboGo_PositiveRegulationOfBiomineralTissueDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","biomineral","tissue","development",",","the","formation","of","hard","tissues","that","consist","mainly","of","inorganic","compounds","."),4046731). assertion_content_comment('tOboGo_PositiveRegulationOfBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","substances","."),3995576). assertion_content_comment('tOboGo_PositiveRegulationOfBipolarCellGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","bipolar","cell","growth",",","polarized","growth","from","both","ends","of","a","cell","."),4118788). assertion_content_comment('tOboGo_PositiveRegulationOfBloodCoagulationCommonPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","blood","coagulation",",","common","pathway","."),4140324). assertion_content_comment('tOboGo_PositiveRegulationOfBloodCoagulationExtrinsicPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","blood","coagulation",",","extrinsic","pathway","."),4140280). assertion_content_comment('tOboGo_PositiveRegulationOfBloodCoagulationIntrinsicPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","blood","coagulation",",","intrinsic","pathway","."),4140206). assertion_content_comment('tOboGo_PositiveRegulationOfBloodCoagulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","blood","coagulation","."),3996584). assertion_content_comment('tOboGo_PositiveRegulationOfBloodMicroparticleFormation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","blood","microparticle","formation","."),4143172). assertion_content_comment('tOboGo_PositiveRegulationOfBloodPressure',s("Any","process","in","which","the","force","of","blood","traveling","through","the","circulatory","system","is","increased","."),3991317). assertion_content_comment('tOboGo_PositiveRegulationOfBloodVesselEndothelialCellMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","migration","of","the","endothelial","cells","of","blood","vessels","."),4094403). assertion_content_comment('tOboGo_PositiveRegulationOfBloodVesselRemodeling',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","blood","vessel","remodeling","."),4145718). assertion_content_comment('tOboGo_PositiveRegulationOfBMKCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","BMK","cascade","."),4136284). assertion_content_comment('tOboGo_PositiveRegulationOfBMPSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","BMP","signaling","pathway","activity","."),4046830). assertion_content_comment('tOboGo_PositiveRegulationOfBorderFollicleCellDelamination',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","border","cell","delamination","."),4052114). assertion_content_comment('tOboGo_PositiveRegulationOfBranchingInvolvedInLungMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","process","in","which","a","highly","ordered","sequence","of","patterning","events","generates","the","branched","structures","of","the","lung",",","consisting","of","reiterated","combinations","of","bud","outgrowth",",","elongation",",","and","dichotomous","subdivision","of","terminal","units","."),4113526). assertion_content_comment('tOboGo_PositiveRegulationOfBranchingInvolvedInUretericBudMorphogenesis',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","branching","involved","in","ureteric","bud","morphogenesis",",","the","process","in","which","the","branching","structure","of","the","ureteric","bud","is","generated","and","organized",".","The","ureteric","bud","is","an","epithelial","tube","that","grows","out","from","the","metanephric","duct",".","The","bud","elongates","and","branches","to","give","rise","to","the","ureter","and","kidney","collecting","tubules","."),4149456). assertion_content_comment('tOboGo_PositiveRegulationOfBranchiomericSkeletalMuscleDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","branchiomeric","skeletal","muscle","development",".","Branchiomeric","skeletal","muscle","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","branchiomeric","skeletal","muscle","over","time",",","from","its","formation","to","the","mature","structure","."),4039886). assertion_content_comment('tOboGo_PositiveRegulationOfBrassinosteroidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","brassinosteroid","biosynthetic","process","."),4145849). assertion_content_comment('tOboGo_PositiveRegulationOfBrownFatCellDifferentiation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","brown","fat","cell","differentiation",".","Brown","fat","cell","differentiation","is","the","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","brown","adipocyte",",","an","animal","connective","tissue","cell","involved","in","adaptive","thermogenesis",".","Brown","adipocytes","contain","multiple","small","droplets","of","triglycerides","and","a","high","number","of","mitochondria","."),4150660). assertion_content_comment('tOboGo_PositiveRegulationOfBrownFatCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","brown","fat","cell","proliferation","."),4136746). assertion_content_comment('tOboGo_PositiveRegulationOfCalciumInER',s("OBSOLETE",".","Any","process","that","increases","the","concentration","of","calcium","in","the","ER","."),4297885). assertion_content_comment('tOboGo_PositiveRegulationOfCalciumIonImport',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","directed","movement","of","calcium","ions","into","a","cell","or","organelle","."),4151724). assertion_content_comment('tOboGo_PositiveRegulationOfCalciumIonTransportIntoCytosol',s("Any","process","that","increases","the","rate","of","the","directed","movement","of","calcium","ions","into","the","cytosol","of","a","cell",".","The","cytosol","is","that","part","of","the","cytoplasm","that","does","not","contain","membranous","or","particulate","subcellular","components","."),4029829). assertion_content_comment('tOboGo_PositiveRegulationOfCalciumIonTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","calcium","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4029820). assertion_content_comment('tOboGo_PositiveRegulationOfCAMPBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4050323). assertion_content_comment('tOboGo_PositiveRegulationOfCAMPCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4050410). assertion_content_comment('tOboGo_PositiveRegulationOfCAMPMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4050305). assertion_content_comment('tOboGo_PositiveRegulationOfCanonicalWntReceptorSignalingPathwayInvolvedInControllingTypeBPancreaticCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","canonical","Wnt","receptor","signaling","pathway","modulating","the","rate","or","frequency","of","pancreatic","B","cell","proliferation","."),4138679). assertion_content_comment('tOboGo_PositiveRegulationOfCanonicalWntReceptorSignalingPathwayInvolvedInNeuralCrestCellDifferentiation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","Wnt","receptor","signaling","pathway","through","beta-catenin","involved","in","neural","crest","cell","differentiation",".","The","Wnt","receptor","signaling","pathway","is","the","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","."),4127074). assertion_content_comment('tOboGo_PositiveRegulationOfCanonicalWntReceptorSignalingPathway',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","Wnt","receptor","signaling","pathway","through","beta-catenin",",","the","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","."),4127069). assertion_content_comment('tOboGo_PositiveRegulationOfCarbohydrateMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","carbohydrate","."),4026348). assertion_content_comment('tOboGo_PositiveRegulationOfCardiacMuscleAdaptation',s("Any","process","that","increases","the","rate",",","extent","or","frequency","of","the","process","in","which","cardiac","muscle","adapts",",","with","consequent","modifications","to","structural","and/or","functional","phenotypes",",","in","response","to","a","stimulus",".","Stimuli","include","contractile","activity",",","loading","conditions",",","substrate","supply",",","and","environmental","factors","."),4028817). assertion_content_comment('tOboGo_PositiveRegulationOfCardiacMuscleCellApoptosis',s("Any","process","that","increases","the","rate","or","extent","of","cardiac","cell","apoptosis",".","Cardiac","cell","apoptosis","is","a","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","cardiac","muscle","cell","and","result","in","its","death","."),4026383). assertion_content_comment('tOboGo_PositiveRegulationOfCardiacMuscleCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cardiac","muscle","cell","proliferation","."),4109228). assertion_content_comment('tOboGo_PositiveRegulationOfCardiacMuscleContraction',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cardiac","muscle","contraction","."),4117647). assertion_content_comment('tOboGo_PositiveRegulationOfCardiacMuscleFiberDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","cardiac","muscle","fiber","development","."),4107859). assertion_content_comment('tOboGo_PositiveRegulationOfCardiacMuscleHypertrophy',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","enlargement","or","overgrowth","of","all","or","part","of","the","heart","due","to","an","increase","in","size","(","not","length",")","of","individual","cardiac","muscle","fibers",",","without","cell","division","."),4028772). assertion_content_comment('tOboGo_PositiveRegulationOfCardiacMuscleTissueDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","cardiac","muscle","tissue","development","."),4107810). assertion_content_comment('tOboGo_PositiveRegulationOfCardiacMuscleTissueGrowth',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","cardiac","muscle","growth","."),4107840). assertion_content_comment('tOboGo_PositiveRegulationOfCardioblastDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cardioblast","differentiation",",","the","process","in","which","a","relatively","unspecialized","mesodermal","cell","acquires","the","specialized","structural","and/or","functional","features","of","a","cardioblast",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4122429). assertion_content_comment('tOboGo_PositiveRegulationOfCaspaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","caspase",",","any","of","a","group","of","cysteine","proteases","involved","in","apoptosis","."),4011564). assertion_content_comment('tOboGo_PositiveRegulationOfCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","substances","."),3979676). assertion_content_comment('tOboGo_PositiveRegulationOfCatagen',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","catagen",",","the","regression","phase","of","the","hair","cycle","."),4122327). assertion_content_comment('tOboGo_PositiveRegulationOfCatalyticActivityInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","enzyme","activity","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4153152). assertion_content_comment('tOboGo_PositiveRegulationOfCatalyticActivity',s("Any","process","that","activates","or","increases","the","activity","of","an","enzyme","."),3972568). assertion_content_comment('tOboGo_PositiveRegulationOfCatecholamineMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","catecholamine","."),4089648). assertion_content_comment('tOboGo_PositiveRegulationOfCatecholamineSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","catecholamine","."),4026693). assertion_content_comment('tOboGo_PositiveRegulationOfCatecholamineUptakeInvolvedInSynapticTransmission',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","catecholamine","neurotransmitters","into","a","neuron","or","glial","cell","."),4120459). assertion_content_comment('tOboGo_PositiveRegulationOfCateninImportIntoNucleus',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","directed","movement","of","a","catenin","protein","from","the","cytoplasm","into","the","nucleus","."),4083152). assertion_content_comment('tOboGo_PositiveRegulationOfCD24BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CD24","biosynthetic","process","."),4144347). assertion_content_comment('tOboGo_PositiveRegulationOfCD40SignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","via","the","CD40","signaling","pathway","."),4143436). assertion_content_comment('tOboGo_PositiveRegulationOfCD4BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","CD4","."),4086266). assertion_content_comment('tOboGo_PositiveRegulationOfCdc42GTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","the","GTPase","Cdc42","."),4317916). assertion_content_comment('tOboGo_PositiveRegulationOfCellActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","activation","."),3989192). assertion_content_comment('tOboGo_PositiveRegulationOfCellAdhesionMediatedByIntegrin',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","cell","adhesion","mediated","by","integrin","."),4063680). assertion_content_comment('tOboGo_PositiveRegulationOfCellAdhesionMoleculeProduction',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","cell","adhesion","molecule","production",".","Cell","adhesion","molecule","production","is","the","appearance","of","a","cell","adhesion","molecule","as","a","result","of","its","biosynthesis","or","a","decrease","in","its","catabolism","."),4115189). assertion_content_comment('tOboGo_PositiveRegulationOfCellAdhesion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","adhesion","."),3988288). assertion_content_comment('tOboGo_PositiveRegulationOfCellAging',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","cell","aging",".","Cell","aging","is","the","progression","of","the","cell","from","its","inception","to","the","end","of","its","lifespan","."),4151020). assertion_content_comment('tOboGo_PositiveRegulationOfCellBudding',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","budding","."),4090708). assertion_content_comment('tOboGo_PositiveRegulationOfCellCommunicationByChemicalCoupling',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cell","communication","via","chemical","coupling",".","Cell","communication","by","chemical","coupling","is","the","process","that","mediates","signaling","interactions","between","one","cell","and","another","cell","by","the","transfer","of","small",",","water-soluble","molecules","or","metabolites","between","their","adjacent","cytoplasms","via","intercellular","protein","channels","."),4026141). assertion_content_comment('tOboGo_PositiveRegulationOfCellCommunicationByElectricalCoupling',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cell","communication","via","electrical","coupling",".","Cell","communication","via","electrical","coupling","is","the","process","that","mediates","signaling","interactions","between","one","cell","and","another","cell","by","transfer","of","current","between","their","adjacent","cytoplasms","via","intercellular","protein","channels","."),4026111). assertion_content_comment('tOboGo_PositiveRegulationOfCellCommunication',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cell","communication",".","Cell","communication","is","the","process","that","mediates","interactions","between","a","cell","and","its","surroundings",".","Encompasses","interactions","such","as","signaling","or","attachment","between","one","cell","and","another","cell",",","between","a","cell","and","an","extracellular","matrix",",","or","between","a","cell","and","any","other","aspect","of","its","environment","."),3987775). assertion_content_comment('tOboGo_PositiveRegulationOfCellCycleArrestInResponseToNitrogenStarvation',s("Any","process","that","increases","the","frequency","or","rate","of","cell","cycle","arrest","in","response","to","nitrogen","starvation","."),4030494). assertion_content_comment('tOboGo_PositiveRegulationOfCellCycleArrest',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","cell","cycle","arrest",",","the","process","in","which","the","cell","cycle","is","halted","during","one","of","the","normal","phases","."),4030491). assertion_content_comment('tOboGo_PositiveRegulationOfCellCycleCytokinesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","division","of","the","cytoplasm","of","a","cell",",","and","its","separation","into","two","daughter","cells",",","that","occurs","in","the","context","of","cell","cycle","progression","."),4129504). assertion_content_comment('tOboGo_PositiveRegulationOfCellCycleProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","a","cellular","process","that","is","involved","in","the","progression","of","biochemical","and","morphological","phases","and","events","that","occur","in","a","cell","during","successive","cell","replication","or","nuclear","replication","events","."),4012246). assertion_content_comment('tOboGo_PositiveRegulationOfCellCycle',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","progression","through","the","cell","cycle","."),4012210). assertion_content_comment('tOboGo_PositiveRegulationOfCellDeath',s("Any","process","that","increases","the","rate","or","frequency","of","cell","death",".","Cell","death","is","the","specific","activation","or","halting","of","processes","within","a","cell","so","that","its","vital","functions","markedly","cease",",","rather","than","simply","deteriorating","gradually","over","time",",","which","culminates","in","cell","death","."),3983054). assertion_content_comment('tOboGo_PositiveRegulationOfCellDevelopment',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","progression","of","the","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","specific","fate","."),3990324). assertion_content_comment('tOboGo_PositiveRegulationOfCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","differentiation","."),3989158). assertion_content_comment('tOboGo_PositiveRegulationOfCellDivision',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","division","."),4035477). assertion_content_comment('tOboGo_PositiveRegulationOfCellFateCommitment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency","or","rate","of","cell","fate","commitment",".","Cell","fate","commitment","is","the","commitment","of","cells","to","specific","cell","fates","and","their","capacity","to","differentiate","into","particular","kinds","of","cells",".","Positional","information","is","established","through","protein","signals","that","emanate","from","a","localized","source","within","a","cell","(","the","initial","one-cell","zygote",")","or","within","a","developmental","field","."),4029401). assertion_content_comment('tOboGo_PositiveRegulationOfCellFateSpecification',s("Any","process","that","activates","or","enables","a","cell","to","adopt","a","specific","fate","."),4032724). assertion_content_comment('tOboGo_PositiveRegulationOfCellGrowthInvolvedInCardiacMuscleCellDevelopment',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","growth","of","a","cardiac","muscle","cell",",","where","growth","contributes","to","the","progression","of","the","cell","over","time","from","its","initial","formation","to","its","mature","state","."),4113415). assertion_content_comment('tOboGo_PositiveRegulationOfCellGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","growth","."),4048569). assertion_content_comment('tOboGo_PositiveRegulationOfCellKilling',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","killing","."),3984367). assertion_content_comment('tOboGo_PositiveRegulationOfCellMigrationInvolvedInSproutingAngiogenesis',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cell","migration","involved","in","sprouting","angiogenesis",".","Cell","migration","involved","in","sprouting","angiogenesis","is","the","orderly","movement","of","endothelial","cells","into","the","extracellular","matrix","in","order","to","form","new","blood","vessels","contributing","to","the","process","of","sprouting","angiogenesis","."),4149935). assertion_content_comment('tOboGo_PositiveRegulationOfCellMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","migration","."),3997886). assertion_content_comment('tOboGo_PositiveRegulationOfCellMorphogenesisInvolvedInDifferentiation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cell","morphogenesis","contributing","to","cell","differentiation",".","Cell","morphogenesis","involved","in","differentiation","is","the","change","in","form","(","cell","shape","and","size",")","that","occurs","when","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","cells",",","tissues",",","or","organs","of","the","mature","organism","or","some","other","relatively","stable","phase","of","the","organism","'","s","life","history","."),4025094). assertion_content_comment('tOboGo_PositiveRegulationOfCellMotility',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","motility","."),3997880). assertion_content_comment('tOboGo_PositiveRegulationOfCellProjectionOrganization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cell","projections","."),4028512). assertion_content_comment('tOboGo_PositiveRegulationOfCellProliferationInBoneMarrow',s("A","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","proliferation","in","the","bone","marrow","."),4082085). assertion_content_comment('tOboGo_PositiveRegulationOfCellProliferationInvolvedInCompoundEyeMorphogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","compound","eye","morphogenesis","."),4145597). assertion_content_comment('tOboGo_PositiveRegulationOfCellProliferationInvolvedInHeartMorphogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","heart","morphogenesis","."),4002980). assertion_content_comment('tOboGo_PositiveRegulationOfCellProliferationInvolvedInHeartValveMorphogenesis',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","cell","proliferation","that","contributes","to","the","shaping","of","a","heart","valve","."),4002983). assertion_content_comment('tOboGo_PositiveRegulationOfCellProliferationInvolvedInMesonephrosDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","mesonephros","development","."),4138225). assertion_content_comment('tOboGo_PositiveRegulationOfCellSize',s("Any","process","that","increases","cell","size","."),4048550). assertion_content_comment('tOboGo_PositiveRegulationOfCellularAmideCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","amides","."),4066866). assertion_content_comment('tOboGo_PositiveRegulationOfCellularAmideMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amides","."),4066839). assertion_content_comment('tOboGo_PositiveRegulationOfCellularAmineCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","leading","to","the","breakdown","of","amines","."),4066916). assertion_content_comment('tOboGo_PositiveRegulationOfCellularAmineMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amines","."),4031217). assertion_content_comment('tOboGo_PositiveRegulationOfCellularAminoAcidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cellular","amino","acid","biosynthetic","process","."),4140087). assertion_content_comment('tOboGo_PositiveRegulationOfCellularAminoAcidMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amino","acid","."),4031221). assertion_content_comment('tOboGo_PositiveRegulationOfCellularBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","substances",",","carried","out","by","individual","cells","."),3996843). assertion_content_comment('tOboGo_PositiveRegulationOfCellularCarbohydrateMetabolicProcess',s("Any","process","that","increases","the","rate",",","extent","or","frequency","of","the","chemical","reactions","and","pathways","involving","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y",",","as","carried","out","by","individual","cells","."),4026357). assertion_content_comment('tOboGo_PositiveRegulationOfCellularCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","substances",",","carried","out","by","individual","cells","."),3979689). assertion_content_comment('tOboGo_PositiveRegulationOfCellularComponentBiogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cellular","component","biogenesis",",","a","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","cellular","component","."),4089877). assertion_content_comment('tOboGo_PositiveRegulationOfCellularComponentMovement',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","movement","of","a","cellular","component","."),3997869). assertion_content_comment('tOboGo_PositiveRegulationOfCellularComponentOrganization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cell","structures",",","including","the","plasma","membrane","and","any","external","encapsulating","structures","such","as","the","cell","wall","and","cell","envelope","."),3975800). assertion_content_comment('tOboGo_PositiveRegulationOfCellularDefenseResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cellular","defense","response","."),4031522). assertion_content_comment('tOboGo_PositiveRegulationOfCellularExtravasation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","cellular","extravasation","."),3998115). assertion_content_comment('tOboGo_PositiveRegulationOfCellularMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","by","which","individual","cells","transform","chemical","substances","."),3975321). assertion_content_comment('tOboGo_PositiveRegulationOfCellularPHReduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","process","that","reduces","the","internal","pH","of","a","cell","."),4070045). assertion_content_comment('tOboGo_PositiveRegulationOfCellularProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","cellular","process",",","any","of","those","that","are","carried","out","at","the","cellular","level",",","but","are","not","necessarily","restricted","to","a","single","cell",".","For","example",",","cell","communication","occurs","among","more","than","one","cell",",","but","occurs","at","the","cellular","level","."),3975243). assertion_content_comment('tOboGo_PositiveRegulationOfCellularProteinMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","protein",",","occurring","at","the","level","of","an","individual","cell","."),3975851). assertion_content_comment('tOboGo_PositiveRegulationOfCellularResponseToPhosphateStarvation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cellular","response","to","phosphate","starvation","."),4148784). assertion_content_comment('tOboGo_PositiveRegulationOfCellVolume',s("Any","process","that","increases","cell","volume","."),4297759). assertion_content_comment('tOboGo_PositiveRegulationOfCentralBCellAnergy',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","central","B","cell","anergy","."),3999896). assertion_content_comment('tOboGo_PositiveRegulationOfCentralBCellDeletion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","central","B","cell","deletion","."),3999451). assertion_content_comment('tOboGo_PositiveRegulationOfCentralBCellToleranceInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","central","B","cell","tolerance","induction","."),3999647). assertion_content_comment('tOboGo_PositiveRegulationOfCentralGapGeneTranscription',s("The","activation","of","genes","encoding","transcription","factors","in","the","central","region","of","an","insect","embryo","by","a","combination","of","maternal","regulatory","signals","and","interactions","among","themselves",";","exemplified","by","the","activation","of","expression","of","the","Drosophila","Kruppel","gene","by","the","hunchback","and","bicoid","gene","products","."),4019253). assertion_content_comment('tOboGo_PositiveRegulationOfCentralToleranceInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","central","tolerance","induction","."),3995431). assertion_content_comment('tOboGo_PositiveRegulationOfCentrioleReplication',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","centriole","replication","."),4098745). assertion_content_comment('tOboGo_PositiveRegulationOfCentrosomeCycle',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","centrosome","cycle","."),4098695). assertion_content_comment('tOboGo_PositiveRegulationOfCentrosomeDuplication',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","centrosome","duplication",".","Centrosome","duplication","is","the","replication","of","a","centrosome",",","a","structure","comprised","of","a","pair","of","centrioles","and","peri-centriolar","material","from","which","a","microtubule","spindle","apparatus","is","organized","."),4036461). assertion_content_comment('tOboGo_PositiveRegulationOfCeramideBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ceramide","biosynthetic","process","."),4098420). assertion_content_comment('tOboGo_PositiveRegulationOfCerebellarGranuleCellMigrationByCalcium',s("The","process","that","increases","the","extent","of","granule","cell","motility","using","intracellular","calcium","signaling","mechanisms","during","radial","migration","."),4047978). assertion_content_comment('tOboGo_PositiveRegulationOfCerebellarGranuleCellPrecursorProliferation',s("The","process","that","activates","or","increases","the","rate","or","extent","of","granule","cell","precursor","proliferation","."),4048723). assertion_content_comment('tOboGo_PositiveRegulationOfCGMPBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cGMP","."),4050613). assertion_content_comment('tOboGo_PositiveRegulationOfCGMPCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cGMP","."),4051008). assertion_content_comment('tOboGo_PositiveRegulationOfCGMPMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","cGMP","."),4050577). assertion_content_comment('tOboGo_PositiveRegulationOfChemokineBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","chemokines","."),4096962). assertion_content_comment('tOboGo_PositiveRegulationOfChemokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","chemokine","production","."),4068255). assertion_content_comment('tOboGo_PositiveRegulationOfChemokineSecretion',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","chemokine","secretion",",","the","regulated","release","of","chemokines","from","a","cell","or","group","of","cells","."),4084164). assertion_content_comment('tOboGo_PositiveRegulationOfChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","."),3998209). assertion_content_comment('tOboGo_PositiveRegulationOfCholesterolBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cholesterol","."),4088845). assertion_content_comment('tOboGo_PositiveRegulationOfCholesterolEfflux',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cholesterol","efflux",".","Cholesterol","efflux","is","the","directed","movement","of","cholesterol",",","cholest-5-en-3-beta-ol",",","out","of","a","cell","or","organelle","."),4037355). assertion_content_comment('tOboGo_PositiveRegulationOfCholesterolEsterification',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cholesterol","esterification",".","Cholesterol","esterification","is","the","lipid","modification","process","in","which","a","sterol","ester","is","formed","by","the","combination","of","a","carboxylic","acid","(","often","a","fatty","acid",")","and","cholesterol",".","In","the","blood","this","process","is","associated","with","the","conversion","of","free","cholesterol","into","cholesteryl","ester",",","which","is","then","sequestered","into","the","core","of","a","lipoprotein","particle","."),4037172). assertion_content_comment('tOboGo_PositiveRegulationOfCholesterolHomeostasis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cholesterol","homeostasis","."),4141378). assertion_content_comment('tOboGo_PositiveRegulationOfCholesterolMetabolicProcess',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","cholesterol","metabolism",",","the","chemical","reactions","and","pathways","involving","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4088842). assertion_content_comment('tOboGo_PositiveRegulationOfCholesterolStorage',s("Any","process","that","increases","the","rate","or","extent","of","cholesterol","storage",".","Cholesterol","storage","is","the","accumulation","and","maintenance","in","cells","or","tissues","of","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4037517). assertion_content_comment('tOboGo_PositiveRegulationOfCholesterolTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","cholesterol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4037347). assertion_content_comment('tOboGo_PositiveRegulationOfChromatinAssemblyOrDisassembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chromatin","assembly","or","disassembly","."),4060889). assertion_content_comment('tOboGo_PositiveRegulationOfChromatinBinding',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","chromatin","binding",".","Chromatin","binding","is","the","selective","interaction","with","chromatin",",","the","network","of","fibers","of","DNA","and","protein","that","make","up","the","chromosomes","of","the","eukaryotic","nucleus","during","interphase","."),4378527). assertion_content_comment('tOboGo_PositiveRegulationOfChromatinSilencingAtCentromere',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","chromatin","silencing","at","the","centromere",".","Chromatin","silencing","at","the","centromere","is","the","repression","of","transcription","of","centromeric","DNA","by","altering","the","structure","of","chromatin","."),4150138). assertion_content_comment('tOboGo_PositiveRegulationOfChromatinSilencingAtTelomere',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chromatin","silencing","at","telomeres","."),4057642). assertion_content_comment('tOboGo_PositiveRegulationOfChromatinSilencing',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chromatin","silencing","."),4057621). assertion_content_comment('tOboGo_PositiveRegulationOfChromosomeSegregation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chromosome","segregation",",","the","process","in","which","genetic","material",",","in","the","form","of","chromosomes",",","is","organized","and","then","physically","separated","and","apportioned","to","two","or","more","sets","."),4120760). assertion_content_comment('tOboGo_PositiveRegulationOfChronicInflammatoryResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","chronic","inflammatory","response","."),3998414). assertion_content_comment('tOboGo_PositiveRegulationOfChronicInflammatoryResponseToAntigenicStimulus',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","chronic","inflammatory","response","to","an","antigenic","stimulus","."),4000623). assertion_content_comment('tOboGo_PositiveRegulationOfChylomicronRemnantClearance',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","chylomicron","remnant","clearance",".","Chylomicron","clearance","is","the","process","in","which","a","chylomicron","remnant","is","removed","from","the","blood","via","receptor-mediated","endocytosis","into","liver","cells","and","its","constituent","parts","degraded","."),4150814). assertion_content_comment('tOboGo_PositiveRegulationOfChylomicronRemodeling',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","chylomicron","remodeling",".","Chylomicron","remodeling","is","the","acquisition",",","loss","or","modification","of","a","protein","or","lipid","within","a","chylomicron",",","including","the","hydrolysis","of","triglyceride","by","lipoprotein","lipase","and","the","subsequent","loss","of","free","fatty","acid","."),4150793). assertion_content_comment('tOboGo_PositiveRegulationOfCiliumMovement',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","cilium","movement",",","the","directed",",","self-propelled","movement","of","a","cilium","."),4005869). assertion_content_comment('tOboGo_PositiveRegulationOfCircadianRhythm',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","circadian","rhythm","behavior","."),4036827). assertion_content_comment('tOboGo_PositiveRegulationOfCircadianSleepWakeCycleREMSleep',s("Any","process","that","activates","or","increases","the","duration","or","quality","of","rapid","eye","movement","(","REM",")","sleep","."),4091969). assertion_content_comment('tOboGo_PositiveRegulationOfCircadianSleepWakeCycleSleep',s("Any","process","that","activates","or","increases","the","duration","or","quality","of","sleep",",","a","readily","reversible","state","of","reduced","awareness","and","metabolic","activity","that","occurs","periodically","in","many","animals","."),4089784). assertion_content_comment('tOboGo_PositiveRegulationOfCircadianSleepWakeCycleWakefulness',s("Any","process","that","increases","the","frequency",",","or","extent","of","the","wakeful","phase","of","the","circadian","sleep/wake","cycle",".","The","wakeful","phase","is","the","part","of","the","circadian","sleep/wake","cycle","where","the","organism","is","not","asleep","."),4036837). assertion_content_comment('tOboGo_PositiveRegulationOfCleistotheciumDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cleistothecium","development",",","a","process","that","leads","to","the","formation","of","a","cleistothecium",".","The","cleistothecium","is","a","closed","sexual","fruiting","body","that","contains","ascospores","in","linear","asci",",","characteristic","of","some","filamentous","Ascomycete","fungi","such","as","members","of","the","genera","Aspergillus","and","Emericella","."),4132721). assertion_content_comment('tOboGo_PositiveRegulationOfCoagulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","coagulation","."),3996575). assertion_content_comment('tOboGo_PositiveRegulationOfCoenzymeAndProstheticGroupMetabolicProcess',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","coenzymes","and","prosthetic","groups","."),4351923). assertion_content_comment('tOboGo_PositiveRegulationOfCoenzymeMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","coenzyme","."),4119681). assertion_content_comment('tOboGo_PositiveRegulationOfCofactorMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","cofactor","."),4119632). assertion_content_comment('tOboGo_PositiveRegulationOfCollagenBinding',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","collagen","binding","."),4338678). assertion_content_comment('tOboGo_PositiveRegulationOfCollagenMetabolicProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","metabolism","of","collagen",",","any","of","a","group","of","fibrous","proteins","of","very","high","tensile","strength","that","form","the","main","component","of","connective","tissue","in","animals","."),4026866). assertion_content_comment('tOboGo_PositiveRegulationOfCollateralSproutingInAbsenceOfInjury',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","collateral","sprouting","in","the","absence","of","injury","."),4107180). assertion_content_comment('tOboGo_PositiveRegulationOfCollateralSproutingOfInjuredAxon',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","collateral","sprouting","of","an","injured","axon","."),4106985). assertion_content_comment('tOboGo_PositiveRegulationOfCollateralSproutingOfIntactAxonInResponseToInjury',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","collateral","sprouting","of","an","intact","axon","as","a","result","of","injury","to","an","axon","."),4106947). assertion_content_comment('tOboGo_PositiveRegulationOfCollateralSprouting',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","collateral","sprouting","."),4106788). assertion_content_comment('tOboGo_PositiveRegulationOfComplementActivationAlternativePathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","complement","activation","by","the","alternative","pathway","."),4092574). assertion_content_comment('tOboGo_PositiveRegulationOfComplementActivationClassicalPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","complement","activation","by","the","classical","pathway","."),4092624). assertion_content_comment('tOboGo_PositiveRegulationOfComplementActivationLectinPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","complement","activation","by","the","lectin","pathway","."),3986488). assertion_content_comment('tOboGo_PositiveRegulationOfComplementActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","complement","activation","."),3986479). assertion_content_comment('tOboGo_PositiveRegulationOfCompoundEyePhotoreceptorDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","compound","eye","photoreceptor","development","."),4085749). assertion_content_comment('tOboGo_PositiveRegulationOfCompoundEyePigmentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","compound","eye","."),4104234). assertion_content_comment('tOboGo_PositiveRegulationOfCompoundEyeRetinalCellProgrammedCellDeath',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death","that","occurs","in","the","compound","eye","retina","."),4099177). assertion_content_comment('tOboGo_PositiveRegulationOfConidiophoreDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","conidiophore","development",",","a","process","that","leads","to","the","formation","of","a","conidiophore",".","The","conidiophore","is","a","specialized","hypha","that","extends","aerially","from","the","growth","substrate","and","bears","conidia",",","or","asexual","spores","."),4132743). assertion_content_comment('tOboGo_PositiveRegulationOfConidiophoreStalkDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","conidiophore","stalk","development",",","a","process","that","leads","to","the","formation","of","a","conidiophore","stalk",".","The","conidiophore","stalk","is","part","of","a","specialized","hypha","that","extends","aerially","from","the","growth","substrate","and","supports","structures","from","which","conidia",",","or","asexual","spores",",","develop","."),4132536). assertion_content_comment('tOboGo_PositiveRegulationOfConidiumFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","conidium","formation",",","a","processes","leading","to","the","production","of","a","type","of","asexual","non-motile","reproductive","spore","of","fungi","via","mitosis","at","the","tip","or","side","of","hyphae","or","on","special","spore-producing","structures","called","conidiophores","."),4148084). assertion_content_comment('tOboGo_PositiveRegulationOfConjugation',s("Any","process","that","increases","the","rate","or","frequency","of","conjugation","."),4029909). assertion_content_comment('tOboGo_PositiveRegulationOfConjugationWithCellularFusion',s("Any","process","that","increases","the","rate","or","frequency","of","conjugation","with","cellular","fusion","."),4029918). assertion_content_comment('tOboGo_PositiveRegulationOfConnectiveTissueGrowthFactorBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","connective","tissue","growth","factor","."),4089607). assertion_content_comment('tOboGo_PositiveRegulationOfConnectiveTissueGrowthFactorProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","connective","tissue","growth","factor","production","."),4068385). assertion_content_comment('tOboGo_PositiveRegulationOfCoreceptorActivityInvolvedInEpidermalGrowthFactorReceptorSignalingPathway',s("Any","process","that","increases","the","rate","or","frequency","of","coreceptor","activity","involved","in","epidermal","growth","factor","receptor","signaling","pathway","."),4161179). assertion_content_comment('tOboGo_PositiveRegulationOfCorticalGranuleExocytosisByElevationOfCytosolicCalciumIonConcentration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cortical","granule","exocytosis","by","directing","movement","of","calcium","ions","(","Ca2","+",")","into","the","cytosol","."),4117932). assertion_content_comment('tOboGo_PositiveRegulationOfCorticotropinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","corticotropin","hormone","from","a","cell","or","group","of","cells","."),4118524). assertion_content_comment('tOboGo_PositiveRegulationOfCortisolBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cortisol","biosynthetic","process","."),4138918). assertion_content_comment('tOboGo_PositiveRegulationOfCortisolSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","cortisol","from","a","cell","or","group","of","cells","."),4118403). assertion_content_comment('tOboGo_PositiveRegulationOfCREBTranscriptionFactorActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","activity","of","the","transcription","factor","CREB","."),4337698). assertion_content_comment('tOboGo_PositiveRegulationOfCrystalCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","crystal","cell","differentiation","."),4078064). assertion_content_comment('tOboGo_PositiveRegulationOfCumulusCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ovarian","cumulus","cell","differentiation","."),4088402). assertion_content_comment('tOboGo_PositiveRegulationOfCuticlePigmentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","cuticle","of","an","organism","."),4104097). assertion_content_comment('tOboGo_PositiveRegulationOfCyanophoreDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cyanophore","differentiation","."),4104896). assertion_content_comment('tOboGo_PositiveRegulationOfCyclaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","cyclase","."),4153186). assertion_content_comment('tOboGo_PositiveRegulationOfCyclicNucleotideBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cyclic","nucleotides","."),4050283). assertion_content_comment('tOboGo_PositiveRegulationOfCyclicNucleotideCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cyclic","nucleotides","."),4050382). assertion_content_comment('tOboGo_PositiveRegulationOfCyclicNucleotideMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","cyclic","nucleotides","."),4050250). assertion_content_comment('tOboGo_PositiveRegulationOfCyclinCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cyclin","catabolic","process","."),4143821). assertion_content_comment('tOboGo_PositiveRegulationOfCytokineActivity',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","activity","of","a","molecule","that","controls","the","survival",",","growth",",","differentiation","and","effector","function","of","tissues","and","cells","."),4160594). assertion_content_comment('tOboGo_PositiveRegulationOfCytokineBiosyntheticProcessInvolvedInImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","cytokine","biosynthesis","contributing","to","an","immune","response","."),3996868). assertion_content_comment('tOboGo_PositiveRegulationOfCytokineBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cytokines","."),3996856). assertion_content_comment('tOboGo_PositiveRegulationOfCytokineProductionInvolvedInImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","cytokine","production","that","contributes","to","an","immune","response","."),3997169). assertion_content_comment('tOboGo_PositiveRegulationOfCytokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","production","of","a","cytokine","."),3984252). assertion_content_comment('tOboGo_PositiveRegulationOfCytokineSecretionInvolvedInImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","cytokine","secretion","contributing","to","an","immune","response","."),3997041). assertion_content_comment('tOboGo_PositiveRegulationOfCytokineSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","cytokines","from","a","cell","or","group","of","cells","."),3997033). assertion_content_comment('tOboGo_PositiveRegulationOfCytokinesisActomyosinContractileRingAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cytokinesis",",","actomyosin","contractile","ring","assembly","."),4142072). assertion_content_comment('tOboGo_PositiveRegulationOfCytokinesisByBinaryFission',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cytokinesis","by","binary","fission","."),4140501). assertion_content_comment('tOboGo_PositiveRegulationOfCytokinesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cytokinesis","."),4035485). assertion_content_comment('tOboGo_PositiveRegulationOfCytokininMediatedSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","cytokinin","."),4148761). assertion_content_comment('tOboGo_PositiveRegulationOfCytolysisBySymbiontOfHostCells',s("Any","process","in","which","an","organism","activates","or","increases","the","frequency",",","rate","or","extent","of","cytolysis","by","that","organism","of","cells","in","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3985965). assertion_content_comment('tOboGo_PositiveRegulationOfCytolysisInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates","or","increases","the","frequency",",","rate","or","extent","of","cytolysis","by","that","organism","of","cells","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3985955). assertion_content_comment('tOboGo_PositiveRegulationOfCytolysisInOtherOrganism',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","cytolysis","by","an","organism","of","cells","in","another","organism","."),3985944). assertion_content_comment('tOboGo_PositiveRegulationOfCytolysis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cytolysis","."),4089715). assertion_content_comment('tOboGo_PositiveRegulationOfCytoplasmicMRNAProcessingBodyAssembly',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","aggregation",",","arrangement","and","bonding","together","of","proteins","and","RNA","molecules","to","form","a","cytoplasmic","mRNA","processing","body","."),4028241). assertion_content_comment('tOboGo_PositiveRegulationOfCytoskeletonOrganization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","."),4051275). assertion_content_comment('tOboGo_PositiveRegulationOfCytoskeleton',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","organization",",","biogenesis","or","maintenance","of","the","cytoskeleton","."),4297739). assertion_content_comment('tOboGo_PositiveRegulationOfCytotoxicTCellDegranulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cytotoxic","T","cell","degranulation","."),4095564). assertion_content_comment('tOboGo_PositiveRegulationOfCytotoxicTCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cytotoxic","T","cell","differentiation","."),4088449). assertion_content_comment('tOboGo_PositiveRegulationOfDauerLarvalDevelopment',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","dauer","larval","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","dauer","larva","over","time",",","through","the","facultative","diapause","of","the","dauer","(","enduring",")","larval","stage",",","with","specialized","traits","adapted","for","dispersal","and","long-term","survival",",","with","elevated","stress","resistance","and","without","feeding","."),4113569). assertion_content_comment('tOboGo_PositiveRegulationOfDeacetylaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","deacetylase","activity",",","the","catalysis","of","the","hydrolysis","of","an","acetyl","group","or","groups","from","a","substrate","molecule","."),4154868). assertion_content_comment('tOboGo_PositiveRegulationOfDecapentaplegicReceptorSignalingPathway',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","the","decapentaplegic","receptor","signaling","pathway",".","The","decapentaplegic","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","a","decapentaplegic","receptor","binding","to","one","of","its","physiological","ligands","."),4150440). assertion_content_comment('tOboGo_PositiveRegulationOfDefecation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","defecation","."),4140007). assertion_content_comment('tOboGo_PositiveRegulationOfDefenseResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","defense","response","."),3983462). assertion_content_comment('tOboGo_PositiveRegulationOfDefenseResponseToVirusByHost',s("Any","host","process","that","results","in","the","promotion","of","antiviral","immune","response","mechanisms",",","thereby","limiting","viral","replication","."),4377489). assertion_content_comment('tOboGo_PositiveRegulationOfDendriteMorphogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","dendrite","morphogenesis","."),4100985). assertion_content_comment('tOboGo_PositiveRegulationOfDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","dendritic","cell","antigen","processing","and","presentation","."),3994659). assertion_content_comment('tOboGo_PositiveRegulationOfDendriticCellChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","dendritic","cell","chemotaxis","."),4144795). assertion_content_comment('tOboGo_PositiveRegulationOfDendriticCellCytokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","dendritic","cell","cytokine","production","."),3997189). assertion_content_comment('tOboGo_PositiveRegulationOfDendriticCellDendriteAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","dendritic","cell","dendrite","assembly","."),4145027). assertion_content_comment('tOboGo_PositiveRegulationOfDendriticSpineDevelopment',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","dendritic","spine","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","dendritic","spine","over","time",",","from","its","formation","to","the","mature","structure","."),4113144). assertion_content_comment('tOboGo_PositiveRegulationOfDendriticSpineMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","dendritic","spine","morphogenesis",",","the","process","in","which","the","anatomical","structures","of","a","dendritic","spine","are","generated","and","organized",".","A","dendritic","spine","is","a","protrusion","from","a","dendrite","and","a","specialized","subcellular","compartment","involved","in","synaptic","transmission","."),4113269). assertion_content_comment('tOboGo_PositiveRegulationOfDeoxyribonucleaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","deoxyribonuclease","activity",",","the","hydrolysis","of","ester","linkages","within","deoxyribonucleic","acid","."),4330580). assertion_content_comment('tOboGo_PositiveRegulationOfDephosphorylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","removal","of","phosphate","groups","from","a","molecule","."),4071106). assertion_content_comment('tOboGo_PositiveRegulationOfDermatomeDevelopment',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","progression","of","the","dermatome","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","dermatome","is","the","portion","of","a","somite","that","will","form","skin","."),4136096). assertion_content_comment('tOboGo_PositiveRegulationOfDeterminationOfDorsalIdentity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","determination","of","dorsal","identity","."),4139446). assertion_content_comment('tOboGo_PositiveRegulationOfDevelopmentalGrowth',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","developmental","growth","."),4040239). assertion_content_comment('tOboGo_PositiveRegulationOfDevelopmentalPigmentation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","developmental","process","that","results","in","the","deposition","of","coloring","matter","in","an","organism","."),4086948). assertion_content_comment('tOboGo_PositiveRegulationOfDevelopmentalProcess',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","development",",","the","biological","process","whose","specific","outcome","is","the","progression","of","an","organism","over","time","from","an","initial","condition","(","e.g",".","a","zygote",",","or","a","young","adult",")","to","a","later","condition","(","e.g",".","a","multicellular","animal","or","an","aged","adult",")"),3985528). assertion_content_comment('tOboGo_PositiveRegulationOfDevelopmentHeterochronic',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","progression","an","integrated","living","unit",":","an","anatomical","structure","(","which","may","be","a","subcellular","structure",",","cell",",","tissue",",","or","organ",")",",","or","organism","over","time","from","an","initial","condition","to","a","later","condition","at","a","consistent","predetermined","time","point","during","its","development","."),4297949). assertion_content_comment('tOboGo_PositiveRegulationOfDevelopmentOfSymbiontInHost',s("Any","process","in","which","the","symbiont","activates","or","maintains","its","progression","from","an","initial","condition","to","a","later","condition",",","within","the","cells","or","tissues","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4097843). assertion_content_comment('tOboGo_PositiveRegulationOfDevelopmentOfSymbiontInvolvedInInteractionWithHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","progression","of","an","organism","from","an","initial","condition","to","a","later","condition",",","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4097667). assertion_content_comment('tOboGo_PositiveRegulationOfDevelopmentOfSymbiontOnOrNearHostSurface',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","'","s","progression","from","an","initial","condition","to","a","later","condition",",","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4097671). assertion_content_comment('tOboGo_PositiveRegulationOfDigestiveSystemProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","a","digestive","system","process",",","a","physical",",","chemical",",","or","biochemical","process","carried","out","by","living","organisms","to","break","down","ingested","nutrients","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),4090966). assertion_content_comment('tOboGo_PositiveRegulationOfDiuresisByAngiotensin',s("OBSOLETE",".","Any","process","mediated","by","angiotensin","that","increases","the","rate","of","diuresis","."),4193606). assertion_content_comment('tOboGo_PositiveRegulationOfDiuresisByPressureNatriuresis',s("OBSOLETE",".","The","process","in","which","pressure","natriuresis","increases","the","rate","of","diuresis","."),4289271). assertion_content_comment('tOboGo_PositiveRegulationOfDiuresis',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","diuresis",".","Diuresis","is","the","process","of","renal","water","excretion","."),4193585). assertion_content_comment('tOboGo_PositiveRegulationOfDNABinding',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","DNA","binding",".","DNA","binding","is","any","process","in","which","a","gene","product","interacts","selectively","with","DNA","(","deoxyribonucleic","acid",")"),4160173). assertion_content_comment('tOboGo_PositiveRegulationOfDNABiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","biosynthetic","process","."),4144178). assertion_content_comment('tOboGo_PositiveRegulationOfDNADamageCheckpoint',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","DNA","damage","checkpoint","."),4139604). assertion_content_comment('tOboGo_PositiveRegulationOfDNADamageResponseSignalTransductionByP53ClassMediator',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","the","cascade","of","processes","induced","by","the","cell","cycle","regulator","phosphoprotein","p53",",","or","an","equivalent","protein",",","in","response","to","the","detection","of","DNA","damage","."),4094580). assertion_content_comment('tOboGo_PositiveRegulationOfDNAEndoreduplication',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","endoreduplication","."),4064840). assertion_content_comment('tOboGo_PositiveRegulationOfDNALigation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","ligation",",","the","re-formation","of","a","broken","phosphodiester","bond","in","the","DNA","backbone",",","carried","out","by","DNA","ligase","."),4119489). assertion_content_comment('tOboGo_PositiveRegulationOfDNAMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","DNA","."),3975359). assertion_content_comment('tOboGo_PositiveRegulationOfDNARecombination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","recombination","."),3975368). assertion_content_comment('tOboGo_PositiveRegulationOfDNARepair',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","repair","."),4055555). assertion_content_comment('tOboGo_PositiveRegulationOfDNAReplicationInvolvedInSPhase',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","replication","that","contributes","to","the","progression","through","S","phase","of","the","cell","cycle","."),4027859). assertion_content_comment('tOboGo_PositiveRegulationOfDNAReplication',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","replication","."),4027847). assertion_content_comment('tOboGo_PositiveRegulationOfDNAStrandElongation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","DNA","strand","elongation",".","DNA","strand","elongation","is","the","DNA","metabolic","process","in","which","a","DNA","strand","is","synthesized","by","adding","nucleotides","to","the","3","'","end","of","an","existing","DNA","stand","."),4114947). assertion_content_comment('tOboGo_PositiveRegulationOfDopamineMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","dopamine","."),4092477). assertion_content_comment('tOboGo_PositiveRegulationOfDopamineReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","dopamine","receptor","protein","signaling","pathway",".","A","dopamine","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","a","dopamine","receptor","binding","to","one","of","its","physiological","ligands","."),4108388). assertion_content_comment('tOboGo_PositiveRegulationOfDopamineSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","dopamine","."),4063440). assertion_content_comment('tOboGo_PositiveRegulationOfDopamineUptake',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","dopamine","into","a","cell","."),4121307). assertion_content_comment('tOboGo_PositiveRegulationOfEarlyEndosomeToLateEndosomeTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","early","endosome","to","late","endosome","transport","."),4137609). assertion_content_comment('tOboGo_PositiveRegulationOfEarlyStripeMelanocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","early","stripe","melanocyte","differentiation","."),4100047). assertion_content_comment('tOboGo_PositiveRegulationOfEcdysteroidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","ecdysteroids","."),4092076). assertion_content_comment('tOboGo_PositiveRegulationOfEcdysteroidMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","ecdysteroids","."),4092066). assertion_content_comment('tOboGo_PositiveRegulationOfEcdysteroidSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","ecdysteroid","."),4092134). assertion_content_comment('tOboGo_PositiveRegulationOfEclosion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","eclosion","."),4090889). assertion_content_comment('tOboGo_PositiveRegulationOfEctodermDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ectoderm","development","."),4142543). assertion_content_comment('tOboGo_PositiveRegulationOfElastinBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","elastin","."),4118857). assertion_content_comment('tOboGo_PositiveRegulationOfEmbryonicDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","embryonic","development","."),4081692). assertion_content_comment('tOboGo_PositiveRegulationOfEmbryoSacCentralCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","embryo","sac","central","cell","differentiation","."),4091587). assertion_content_comment('tOboGo_PositiveRegulationOfEmbryoSacEggCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","embryo","sac","egg","cell","differentiation","."),4091741). assertion_content_comment('tOboGo_PositiveRegulationOfEnamelMineralization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","enamel","mineralization",",","the","deposition","of","calcium","salts","in","tooth","enamel","."),4133413). assertion_content_comment('tOboGo_PositiveRegulationOfEncystedZoosporeGerminationOnOrNearHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","encysted","zoospore","germination","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146328). assertion_content_comment('tOboGo_PositiveRegulationOfEndocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","endocytosis","."),3992661). assertion_content_comment('tOboGo_PositiveRegulationOfEndodeoxyribonucleaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","endodeoxyribonuclease","activity",",","the","hydrolysis","of","ester","linkages","within","deoxyribonucleic","acid","by","creating","internal","breaks","."),4330597). assertion_content_comment('tOboGo_PositiveRegulationOfEndopeptidaseActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","endopeptidase","activity",",","the","endohydrolysis","of","peptide","bonds","within","proteins","."),4336118). assertion_content_comment('tOboGo_PositiveRegulationOfEndothelialCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","endothelial","cell","apoptosis","."),4143504). assertion_content_comment('tOboGo_PositiveRegulationOfEndothelialCellChemotaxisToFibroblastGrowthFactor',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","endothelial","cell","chemotaxis","to","fibroblast","growth","factor","."),4145300). assertion_content_comment('tOboGo_PositiveRegulationOfEndothelialCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","endothelial","cell","differentiation","."),4087105). assertion_content_comment('tOboGo_PositiveRegulationOfEndothelialCellMigration',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","orderly","movement","of","an","endothelial","cell","into","the","extracellular","matrix","to","form","an","endothelium","."),4028534). assertion_content_comment('tOboGo_PositiveRegulationOfEndothelialCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","endothelial","cell","proliferation","."),3988593). assertion_content_comment('tOboGo_PositiveRegulationOfEndothelialMicroparticleFormation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","endothelial","microparticle","formation","."),4143222). assertion_content_comment('tOboGo_PositiveRegulationOfEnergyHomeostasis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","energy","homeostasis","."),4145753). assertion_content_comment('tOboGo_PositiveRegulationOfEosinophilChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","eosinophil","chemotaxis","."),4141844). assertion_content_comment('tOboGo_PositiveRegulationOfEosinophilDegranulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","eosinophil","degranulation","."),4093537). assertion_content_comment('tOboGo_PositiveRegulationOfEosinophilDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","eosinophil","differentiation","."),4087626). assertion_content_comment('tOboGo_PositiveRegulationOfEosinophilExtravasation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","eosinophil","extravasation","."),4141900). assertion_content_comment('tOboGo_PositiveRegulationOfEosinophilMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","eosinophil","migration","."),4141829). assertion_content_comment('tOboGo_PositiveRegulationOfEpidermalCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","epidermal","cell","differentiation","."),4087173). assertion_content_comment('tOboGo_PositiveRegulationOfEpidermalGrowthFactorReceptorActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","epidermal","growth","factor","receptor","activity","."),4217334). assertion_content_comment('tOboGo_PositiveRegulationOfEpidermalGrowthFactorReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","epidermal","growth","factor","receptor","signaling","pathway","activity","."),4091077). assertion_content_comment('tOboGo_PositiveRegulationOfEpidermisDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","epidermis","development","."),4087163). assertion_content_comment('tOboGo_PositiveRegulationOfEpinephrineSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","epinephrine","."),4070669). assertion_content_comment('tOboGo_PositiveRegulationOfEpinephrineUptake',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","epinephrine","into","a","cell","."),4121526). assertion_content_comment('tOboGo_PositiveRegulationOfEpithelialCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","epithelial","cell","differentiation","."),4061767). assertion_content_comment('tOboGo_PositiveRegulationOfEpithelialCellMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","epithelial","cell","migration","."),4028672). assertion_content_comment('tOboGo_PositiveRegulationOfEpithelialCellProliferationInvolvedInLungBudDilation',s("Any","process","that","increases","the","rate","or","frequency","of","epithelial","cell","proliferation","that","results","in","the","lung","bud","increasing","in","size","radially","."),4116705). assertion_content_comment('tOboGo_PositiveRegulationOfEpithelialCellProliferationInvolvedInLungMorphogenesis',s("Any","process","that","increases","the","rate","or","frequency","of","epithelial","cell","proliferation","that","results","in","the","lung","attaining","its","shape","."),4116701). assertion_content_comment('tOboGo_PositiveRegulationOfEpithelialCellProliferationInvolvedInProstateGlandDevelopment',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","epithelial","cell","proliferation","that","contributes","to","the","progression","of","the","prostate","gland","over","time","."),4111028). assertion_content_comment('tOboGo_PositiveRegulationOfEpithelialCellProliferationInvolvedInWoundHealing',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","epithelial","cell","proliferation",",","contributing","to","the","restoration","of","integrity","to","a","damaged","tissue","following","an","injury","."),4109191). assertion_content_comment('tOboGo_PositiveRegulationOfEpithelialCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","epithelial","cell","proliferation","."),3988585). assertion_content_comment('tOboGo_PositiveRegulationOfEpithelialToMesenchymalTransition',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","epithelial","to","mesenchymal","transition",".","Epithelial","to","mesenchymal","transition","is","where","an","epithelial","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","."),4027041). assertion_content_comment('tOboGo_PositiveRegulationOfErgosterolBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","ergosterol","."),4136356). assertion_content_comment('tOboGo_PositiveRegulationOfERK1AndERK2Cascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","ERK1","and","ERK2","cascade","."),4136838). assertion_content_comment('tOboGo_PositiveRegulationOfErythrocyteAggregation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","erythrocyte","aggregation","."),4076825). assertion_content_comment('tOboGo_PositiveRegulationOfErythrocyteClearance',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","erythrocyte","clearance","."),4076788). assertion_content_comment('tOboGo_PositiveRegulationOfErythrocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","erythrocyte","differentiation","."),4087674). assertion_content_comment('tOboGo_PositiveRegulationOfErythrophoreDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","erythrophore","differentiation","."),4105054). assertion_content_comment('tOboGo_PositiveRegulationOfEstablishmentOfBipolarCellPolarityRegulatingCellShape',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","establishment","of","bipolar","cell","polarity","that","regulates","the","shape","of","a","cell","."),4156234). assertion_content_comment('tOboGo_PositiveRegulationOfEstablishmentOfBipolarCellPolarity',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","establishment","of","bipolar","cell","polarity","."),4135939). assertion_content_comment('tOboGo_PositiveRegulationOfEstablishmentOfCompetenceForTransformation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","of","competence","for","transformation","."),4090465). assertion_content_comment('tOboGo_PositiveRegulationOfEstablishmentOfProteinLocalizationInPlasmaMembrane',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","protein","to","a","specific","location","in","the","plasma","membrane","."),4149558). assertion_content_comment('tOboGo_PositiveRegulationOfEstablishmentOfTurgorInAppressorium',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","turgor","formation","in","the","symbiont","appressorium","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147051). assertion_content_comment('tOboGo_PositiveRegulationOfEstablishmentOrMaintenanceOfBipolarCellPolarityRegulatingCellShape',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","or","maintenance","of","bipolar","cell","polarity","regulating","cell","shape","."),4133709). assertion_content_comment('tOboGo_PositiveRegulationOfEstrogenReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","activity","of","an","estrogen","receptor","signaling","pathway","."),4065642). assertion_content_comment('tOboGo_PositiveRegulationOfEthyleneBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","an","ethylene","biosynthetic","process","."),4031260). assertion_content_comment('tOboGo_PositiveRegulationOfEukaryoticCellSurfaceBinding',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","eukaryotic","cell","surface","binding","."),4171934). assertion_content_comment('tOboGo_PositiveRegulationOfExcitatoryPostsynapticMembranePotential',s("Any","process","that","enhances","the","establishment","or","increases","the","extent","of","the","excitatory","postsynaptic","potential","(","EPSP",")","which","is","a","temporary","increase","in","postsynaptic","potential","due","to","the","flow","of","positively","charged","ions","into","the","postsynaptic","cell",".","The","flow","of","ions","that","causes","an","EPSP","is","an","excitatory","postsynaptic","current","(","EPSC",")","and","makes","it","easier","for","the","neuron","to","fire","an","action","potential","."),4171914). assertion_content_comment('tOboGo_PositiveRegulationOfExitFromMitosis',s("Any","process","that","activates","or","increases","the","rate","of","progression","from","anaphase/telophase","(","high","mitotic","CDK","activity",")","to","G1","(","low","mitotic","CDK","activity",")"),4060704). assertion_content_comment('tOboGo_PositiveRegulationOfExocystAssembly',s("Any","process","that","increases","the","rate","or","extent","of","exocyst","assembly","."),3988852). assertion_content_comment('tOboGo_PositiveRegulationOfExocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","exocytosis","."),4089683). assertion_content_comment('tOboGo_PositiveRegulationOfExogen',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","exogen",",","the","shedding","phase","of","the","hair","cycle","."),4122470). assertion_content_comment('tOboGo_PositiveRegulationOfExtentOfHeterochromatinFormation',s("Any","process","that","increases","the","extent","of","heterochromatin","formation",";","increases","the","size","of","a","chromosomal","region","converted","to","heterochromatin","."),4341697). assertion_content_comment('tOboGo_PositiveRegulationOfExtracellularMatrixConstituentSecretion',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","controlled","release","of","molecules","that","form","the","extracellular","matrix",",","including","carbohydrates","and","glycoproteins","by","a","cell","or","a","group","of","cells","."),4006396). assertion_content_comment('tOboGo_PositiveRegulationOfExtracellularMatrixDisassembly',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","extracellular","matrix","disassembly",".","Extracellular","matrix","disassembly","is","a","process","that","results","in","the","breakdown","of","the","extracellular","matrix","."),4150226). assertion_content_comment('tOboGo_PositiveRegulationOfExtraocularSkeletalMuscleDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","extraocular","skeletal","muscle","development",".","Extraocular","skeletal","muscle","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","extraocular","skeletal","muscle","over","time",",","from","its","formation","to","the","mature","structure",".","The","extraocular","muscle","is","derived","from","cranial","mesoderm","and","controls","eye","movements",".","The","muscle","begins","its","development","with","the","differentiation","of","the","muscle","cells","and","ends","with","the","mature","muscle","."),4040326). assertion_content_comment('tOboGo_PositiveRegulationOfExtrathymicTCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","extrathymic","T","cell","differentiation","."),4066349). assertion_content_comment('tOboGo_PositiveRegulationOfEyePhotoreceptorCellDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","eye","photoreceptor","development","."),4078749). assertion_content_comment('tOboGo_PositiveRegulationOfEyePigmentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","eye","of","an","organism","."),4104188). assertion_content_comment('tOboGo_PositiveRegulationOfFasLBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","FasL","."),4086200). assertion_content_comment('tOboGo_PositiveRegulationOfFatCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","adipocyte","differentiation","."),4088351). assertion_content_comment('tOboGo_PositiveRegulationOfFatCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","fat","cell","proliferation","."),4136694). assertion_content_comment('tOboGo_PositiveRegulationOfFattyAcidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","fatty","acids","."),4058577). assertion_content_comment('tOboGo_PositiveRegulationOfFattyAcidMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","fatty","acids","."),4058001). assertion_content_comment('tOboGo_PositiveRegulationOfFattyAcidOxidation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","fatty","acid","oxidation","."),4058011). assertion_content_comment('tOboGo_PositiveRegulationOfFattyAcidTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","fatty","acid","transport","."),4024816). assertion_content_comment('tOboGo_PositiveRegulationOfFcReceptorMediatedStimulatorySignalingPathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","Fc","receptor","mediated","stimulatory","signaling","pathway",".","The","Fc","receptor","mediated","stimulatory","signaling","pathway","is","a","series","of","molecular","signals","generated","as","a","consequence","of","a","the","binding","of","the","Fc","portion","of","an","immunoglobulin","by","an","Fc","receptor","capable","of","activating","or","perpetuating","an","immune","response",".","The","Fc","portion","of","an","immunoglobulin","is","its","C-terminal","constant","region","."),4115024). assertion_content_comment('tOboGo_PositiveRegulationOfFeedingBehavior',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","feeding","behavior","."),4140368). assertion_content_comment('tOboGo_PositiveRegulationOfFemaleGonadDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","female","gonad","development","."),4141401). assertion_content_comment('tOboGo_PositiveRegulationOfFemalePigmentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","females","."),4104370). assertion_content_comment('tOboGo_PositiveRegulationOfFemaleReceptivity',s("Any","process","that","activates","or","increases","the","receptiveness","of","a","female","to","male","advances","."),4298076). assertion_content_comment('tOboGo_PositiveRegulationOfFeverGenerationByPositiveRegulationOfProstaglandinBiosynthesis',s("Any","process","that","increases","the","rate","or","extent","of","fever","generation","via","positive","regulation","of","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","prostaglandin","."),4171135). assertion_content_comment('tOboGo_PositiveRegulationOfFeverGenerationByPositiveRegulationOfProstaglandinSecretion',s("Any","process","that","increases","the","rate","or","extent","of","fever","generation","via","positive","regulation","of","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","prostaglandin","from","a","cell","or","group","of","cells","."),4171082). assertion_content_comment('tOboGo_PositiveRegulationOfFeverGeneration',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","fever","generation","."),4059990). assertion_content_comment('tOboGo_PositiveRegulationOfFibrinolysis',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","fibrinolysis",",","an","ongoing","process","that","solubilizes","fibrin",",","resulting","in","the","removal","of","small","blood","clots","."),4120265). assertion_content_comment('tOboGo_PositiveRegulationOfFibroblastApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","fibroblast","apoptosis","."),4140247). assertion_content_comment('tOboGo_PositiveRegulationOfFibroblastGrowthFactorProduction',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","appearance","of","a","fibroblast","growth","factor","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4151796). assertion_content_comment('tOboGo_PositiveRegulationOfFibroblastGrowthFactorReceptorSignalingPathwayInvolvedInNeuralPlateAnteriorPosteriorPatternFormation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","fibroblast","growth","factor","receptor","signaling","pathway","involved","in","neural","plate","anterior/posterior","pattern","formation","."),4139710). assertion_content_comment('tOboGo_PositiveRegulationOfFibroblastGrowthFactorReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","fibroblast","growth","factor","receptor","signaling","pathway","activity","."),4091096). assertion_content_comment('tOboGo_PositiveRegulationOfFibroblastMigration',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","fibroblast","cell","migration",".","Fibroblast","cell","migration","is","accomplished","by","extension","and","retraction","of","a","pseudopodium","."),4025047). assertion_content_comment('tOboGo_PositiveRegulationOfFibroblastProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","multiplication","or","reproduction","of","fibroblast","cells","."),4103509). assertion_content_comment('tOboGo_PositiveRegulationOfFilamentousGrowth',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","process","in","which","a","multicellular","organism","or","a","group","of","unicellular","organisms","grow","in","a","threadlike",",","filamentous","shape","."),4132674). assertion_content_comment('tOboGo_PositiveRegulationOfFilopodiumAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","assembly","of","a","filopodium",",","a","thin",",","stiff","protrusion","extended","by","the","leading","edge","of","a","motile","cell","such","as","a","crawling","fibroblast","or","amoeba",",","or","an","axonal","growth","cone","."),4119115). assertion_content_comment('tOboGo_PositiveRegulationOfFlagellarCellMotility',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","flagellar","cell","motility","."),4137799). assertion_content_comment('tOboGo_PositiveRegulationOfFlagellumAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","formation","of","a","flagellum","."),4091499). assertion_content_comment('tOboGo_PositiveRegulationOfFlavonoidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","flavonoids","."),4033149). assertion_content_comment('tOboGo_PositiveRegulationOfFloralOrganAbscissionBySmallGTPaseMediatedSignalTransduction',s("Any","series","of","molecular","signals","in","which","a","small","monomeric","GTPase","relays","one","or","more","of","the","signals","that","increases","the","rate","or","extent","of","floral","organ","abscission","."),4156471). assertion_content_comment('tOboGo_PositiveRegulationOfFloralOrganAbscission',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","floral","organ","shedding",",","the","controlled","shedding","of","floral","organs","."),4113896). assertion_content_comment('tOboGo_PositiveRegulationOfFlowerDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","flower","development","."),4021324). assertion_content_comment('tOboGo_PositiveRegulationOfFocalAdhesionAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","focal","adhesion","assembly",",","the","establishment","and","maturation","of","focal","adhesions","."),4122398). assertion_content_comment('tOboGo_PositiveRegulationOfFormationBySymbiontOfHaustoriumForNutrientAcquisitionFromHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","symbiont","haustorium","formation","for","nutrient","acquisition","from","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147112). assertion_content_comment('tOboGo_PositiveRegulationOfFractalkineBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","fractalkine",",","a","chemokine","involved","in","the","control","of","the","key","regulatory","mechanisms","of","cell","trafficking","at","sites","of","inflammation","."),4101185). assertion_content_comment('tOboGo_PositiveRegulationOfFractalkineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","fractalkine","production","."),4068263). assertion_content_comment('tOboGo_PositiveRegulationOfG0ToG1Transition',s("A","cell","cycle","process","that","activates","or","increases","the","rate","or","extent","of","the","transition","from","the","G0","quiescent","state","to","the","G1","phase","."),4137302). assertion_content_comment('tOboGo_PositiveRegulationOfG2MTransitionOfMitoticCellCycle',s("Any","process","that","increases","the","rate","or","extent","of","progression","from","G2","phase","to","M","phase","of","the","mitotic","cell","cycle","."),4035525). assertion_content_comment('tOboGo_PositiveRegulationOfGastricAcidSecretion',s("Any","process","that","increases","the","rate","frequency","or","extent","of","gastric","secretion",".","Gastric","secretion","is","the","regulated","release","of","gastric","acid","(","hydrochloric","acid",")","by","parietal","or","oxyntic","cells","during","digestion","."),4117702). assertion_content_comment('tOboGo_PositiveRegulationOfGastrulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","gastrulation","."),4145184). assertion_content_comment('tOboGo_PositiveRegulationOfGeneExpressionEpigenetic',s("Any","epigenetic","process","that","activates","or","increases","the","rate","of","gene","expression","."),4057673). assertion_content_comment('tOboGo_PositiveRegulationOfGeneExpression',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","gene","expression",".","Gene","expression","is","the","process","in","which","a","gene","'","s","coding","sequence","is","converted","into","a","mature","gene","product","or","products","(","proteins","or","RNA",")","This","includes","the","production","of","an","RNA","transcript","as","well","as","any","processing","to","produce","a","mature","RNA","product","or","an","mRNA","(","for","protein-coding","genes",")","and","the","translation","of","that","mRNA","into","protein",".","Some","protein","processing","events","may","be","included","when","they","are","required","to","form","an","active","form","of","a","product","from","an","inactive","precursor","form","."),4012775). assertion_content_comment('tOboGo_PositiveRegulationOfGeneSilencingByMiRNA',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","gene","silencing","by","miRNA","."),4143906). assertion_content_comment('tOboGo_PositiveRegulationOfGerminalCenterFormation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","germinal","center","formation","."),3995681). assertion_content_comment('tOboGo_PositiveRegulationOfGermTubeFormationOnOrNearHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","germ","tube","formation","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147366). assertion_content_comment('tOboGo_PositiveRegulationOfGibberellicAcidMediatedSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","gibberellic","acid","mediated","signaling","activity","."),4033288). assertion_content_comment('tOboGo_PositiveRegulationOfGibberellinBiosyntheticProcess',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","gibberellins","."),4030957). assertion_content_comment('tOboGo_PositiveRegulationOfGlialCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","glial","cell","apoptosis","."),4075174). assertion_content_comment('tOboGo_PositiveRegulationOfGlialCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glia","cell","differentiation","."),4036255). assertion_content_comment('tOboGo_PositiveRegulationOfGlialCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","glial","cell","proliferation","."),4028963). assertion_content_comment('tOboGo_PositiveRegulationOfGliogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","gliogenesis",",","the","formation","of","mature","glia","."),4028954). assertion_content_comment('tOboGo_PositiveRegulationOfGlomerularMesangialCellProliferation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","glomerular","mesangial","cell","proliferation","."),4122746). assertion_content_comment('tOboGo_PositiveRegulationOfGlomerularMetanephricMesangialCellProliferation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","metanephric","glomerular","mesangial","cell","proliferation","."),4124605). assertion_content_comment('tOboGo_PositiveRegulationOfGlomerulusDevelopment',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","glomerulus","development",",","the","progression","of","the","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney","."),4124546). assertion_content_comment('tOboGo_PositiveRegulationOfGlucagonSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","glucagon","."),4133014). assertion_content_comment('tOboGo_PositiveRegulationOfGlucocorticoidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucocorticoids","."),4057546). assertion_content_comment('tOboGo_PositiveRegulationOfGlucocorticoidCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucocorticoids","."),4057469). assertion_content_comment('tOboGo_PositiveRegulationOfGlucocorticoidMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","glucocorticoids","."),4057446). assertion_content_comment('tOboGo_PositiveRegulationOfGlucocorticoidReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glucocorticoid","receptor","signaling","pathway","."),4139674). assertion_content_comment('tOboGo_PositiveRegulationOfGlucokinaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glucokinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","glucose","molecule","."),4347947). assertion_content_comment('tOboGo_PositiveRegulationOfGluconateTransmembraneTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","gluconate","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083095). assertion_content_comment('tOboGo_PositiveRegulationOfGluconateTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","gluconate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4064703). assertion_content_comment('tOboGo_PositiveRegulationOfGluconeogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","gluconeogenesis","."),4091278). assertion_content_comment('tOboGo_PositiveRegulationOfGlucoseImport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","import","of","the","hexose","monosaccharide","glucose","into","a","cell","or","organelle","."),4098143). assertion_content_comment('tOboGo_PositiveRegulationOfGlucoseMetabolicProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","glucose","metabolism",".","Glucose","metabolic","processes","are","the","chemical","reactions","and","pathways","involving","glucose",",","the","aldohexose","gluco-hexose","."),4038278). assertion_content_comment('tOboGo_PositiveRegulationOfGlucoseTransport',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","glucose","transport",".","Glucose","transport","is","the","directed","movement","of","the","hexose","monosaccharide","glucose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4036560). assertion_content_comment('tOboGo_PositiveRegulationOfGlucosylceramideBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosylceramide","."),4098427). assertion_content_comment('tOboGo_PositiveRegulationOfGlutamateMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glutamate","metabolic","process","."),4141200). assertion_content_comment('tOboGo_PositiveRegulationOfGlutamateSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","controlled","release","of","glutamate","."),4039656). assertion_content_comment('tOboGo_PositiveRegulationOfGlutamateUptakeInvolvedInTransmissionOfNerveImpulse',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","L-glutamate","into","a","neuron","or","glial","cell","."),4120654). assertion_content_comment('tOboGo_PositiveRegulationOfGlutamineTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glutamine","transport","."),4145836). assertion_content_comment('tOboGo_PositiveRegulationOfGlycerolTransport',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","directed","movement","of","glycerol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4151294). assertion_content_comment('tOboGo_PositiveRegulationOfGlycineHydroxymethyltransferaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glycine","hydroxymethyltransferase","activity",",","the","catalysis","of","the","reaction","5",",","10-methylenetetrahydrofolate","+","glycine","+","H2O","=","tetrahydrofolate","+","L-serine","."),4181700). assertion_content_comment('tOboGo_PositiveRegulationOfGlycogenBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycogen","."),4091479). assertion_content_comment('tOboGo_PositiveRegulationOfGlycogenCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycogen","."),4090628). assertion_content_comment('tOboGo_PositiveRegulationOfGlycogenMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","glycogen","."),4090624). assertion_content_comment('tOboGo_PositiveRegulationOfGlycogenStarchSynthaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glycogen","(","starch",")","synthase","activity","."),4171971). assertion_content_comment('tOboGo_PositiveRegulationOfGlycolysis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glycolysis","."),4090651). assertion_content_comment('tOboGo_PositiveRegulationOfGlycoproteinBiosyntheticProcessInvolvedInImmunologicalSynapseFormation',s("Any","positive","regulation","of","glycoprotein","biosynthetic","process","that","is","involved","in","immunological","synapse","formation","."),4144622). assertion_content_comment('tOboGo_PositiveRegulationOfGlycoproteinBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycoproteins",",","any","protein","that","contains","covalently","bound","glycose","(","i.e",".","monosaccharide",")","residues",";","the","glycose","occurs","most","commonly","as","oligosaccharide","or","fairly","small","polysaccharide","but","occasionally","as","monosaccharide","."),4027955). assertion_content_comment('tOboGo_PositiveRegulationOfGolgiToPlasmaMembraneCFTRProteinTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transport","of","Cystic","Fibrosis","Transmembrane","conductance","Regulator","(","CFTR",")","protein","from","the","Golgi","to","the","plasma","membrane","."),4093916). assertion_content_comment('tOboGo_PositiveRegulationOfGolgiToPlasmaMembraneProteinTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","transport","of","proteins","from","the","Golgi","to","the","plasma","membrane","."),4093887). assertion_content_comment('tOboGo_PositiveRegulationOfGolgiVesicleFusionToTargetMembrane',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Golgi","vesicle","fusion","to","target","membrane","."),4103289). assertion_content_comment('tOboGo_PositiveRegulationOfGonadotropinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","gonadotropin","."),4054790). assertion_content_comment('tOboGo_PositiveRegulationOfGranulocyteChemotaxis',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","granulocyte","chemotaxis",".","Granulocyte","chemotaxis","is","the","movement","of","a","granulocyte","in","response","to","an","external","stimulus","."),4130254). assertion_content_comment('tOboGo_PositiveRegulationOfGranulocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","granulocyte","differentiation","."),4061729). assertion_content_comment('tOboGo_PositiveRegulationOfGranulomaFormation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","granuloma","formation","."),3995630). assertion_content_comment('tOboGo_PositiveRegulationOfGranzymeAProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","granzyme","A","production","."),4144876). assertion_content_comment('tOboGo_PositiveRegulationOfGranzymeBProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","granzyme","B","."),4129240). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthHormoneReceptorSignalingPathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","growth","hormone","receptor","signaling","pathway",".","The","growth","hormone","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","growth","hormone","receptor","binding","to","its","physiological","ligand","."),4117407). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthHormoneSecretion',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","growth","hormone","from","a","cell","or","group","of","cells","."),4109002). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthOfSymbiontInHost',s("Any","process","in","which","the","symbiont","activates",",","maintains","or","increases","its","size","or","mass","within","the","cells","or","tissues","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4097856). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthOfSymbiontInvolvedInInteractionWithHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","increase","in","size","or","mass","of","an","organism","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4097639). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthOfSymbiontOnOrNearHostSurface',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","'","s","increase","in","size","or","mass","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4097643). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthOfUnicellularOrganismAsAThreadOfAttachedCells',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","process","in","which","cells","remain","attached","after","division","and","form","thread-like","filaments","that","may","penetrate","into","a","solid","growth","medium","."),4132677). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthOrDevelopmentOfSymbiontDuringInteractionWithHost',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","increase","in","size","or","mass","of","an","organism",",","or","the","progression","of","an","organism","from","an","initial","condition","to","a","later","condition",",","occurring","in",",","on","or","near","the","exterior","of","its","host","organism","."),4154545). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthOrDevelopmentOfSymbiontInHost',s("OBSOLETE",".","Any","process","by","which","the","symbiont","activates",",","maintains","or","increases","its","size","or","mass","or","its","progression","from","an","initial","condition","to","a","later","condition",",","within","the","cells","or","tissues","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4341405). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthOrDevelopmentOfSymbiontOnOrNearHostSurface',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","'","s","increase","in","size","or","mass",",","or","its","progression","from","an","initial","condition","to","a","later","condition",",","on","or","near","the","cells","or","tissues","of","the","host","organism","."),4154569). assertion_content_comment('tOboGo_PositiveRegulationOfGrowthRate',s("Any","process","that","increases","the","rate","of","growth","of","all","or","part","of","an","organism","."),4234353). assertion_content_comment('tOboGo_PositiveRegulationOfGrowth',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","growth",",","the","increase","in","size","or","mass","of","all","or","part","of","an","organism","."),4040229). assertion_content_comment('tOboGo_PositiveRegulationOfGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","GTPase","."),4317896). assertion_content_comment('tOboGo_PositiveRegulationOfGTPCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","GTP",",","guanosine","triphosphate","."),4065934). assertion_content_comment('tOboGo_PositiveRegulationOfGTPCyclohydrolaseIActivity',s("Any","process","that","activates","or","increases","the","activity","of","the","enzyme","GTP","cyclohydrolase","I","."),4317660). assertion_content_comment('tOboGo_PositiveRegulationOfGuanylateCyclaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","guanylate","cyclase","activity","."),4320196). assertion_content_comment('tOboGo_PositiveRegulationOfHairCycle',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","cyclical","phases","of","growth","(","anagen",")",",","regression","(","catagen",")",",","quiescence","(","telogen",")",",","and","shedding","(","exogen",")","in","the","life","of","a","hair","."),4077889). assertion_content_comment('tOboGo_PositiveRegulationOfHairFollicleCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","hair","follicle","cell","proliferation","."),4128407). assertion_content_comment('tOboGo_PositiveRegulationOfHairFollicleDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","hair","follicle","development","."),4105537). assertion_content_comment('tOboGo_PositiveRegulationOfHairFollicleMaturation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","hair","follicle","maturation","."),4105545). assertion_content_comment('tOboGo_PositiveRegulationOfHairPlacodeFormation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","hair","follicle","placode","formation",",","the","developmental","process","in","which","a","hair","placode","forms",".","An","hair","follicle","placode","is","a","thickening","of","the","ectoderm","that","will","give","rise","to","the","hair","follicle","bud","."),4135783). assertion_content_comment('tOboGo_PositiveRegulationOfHaustoriumMotherCellFormationOnOrNearHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","symbiont","haustorium","mother","cell","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146693). assertion_content_comment('tOboGo_PositiveRegulationOfHeartContraction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","heart","contraction","."),3991554). assertion_content_comment('tOboGo_PositiveRegulationOfHeartGrowth',s("Any","process","that","increases","the","rate","or","extent","of","heart","growth",".","Heart","growth","is","the","increase","in","size","or","mass","of","the","heart","."),4107836). assertion_content_comment('tOboGo_PositiveRegulationOfHeartInductionByNegativeRegulationOfCanonicalWntReceptorSignalingPathway',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","canonical","Wnt","receptor","signaling","pathway","that","positively","regulates","heart","induction",".","Canonical","Wnt","receptor","signaling","pathway","involved","in","heart","induction","is","the","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","."),4150167). assertion_content_comment('tOboGo_PositiveRegulationOfHeartRateByCirculatingEpinephrine',s("The","process","in","which","the","secretion","of","epinephrine","into","the","bloodstream","increases","the","rate","of","heart","muscle","contraction","."),4193806). assertion_content_comment('tOboGo_PositiveRegulationOfHeartRateByCirculatingNorepinephrine',s("The","process","in","which","the","secretion","of","norepinephrine","into","the","bloodstream","increases","the","rate","of","heart","muscle","contraction","."),4193785). assertion_content_comment('tOboGo_PositiveRegulationOfHeartRateByEpinephrine',s("The","process","in","which","the","secretion","of","epinephrine","into","the","bloodstream","or","released","from","nerve","endings","increases","the","rate","of","heart","muscle","contraction","."),4003834). assertion_content_comment('tOboGo_PositiveRegulationOfHeartRateByNeuronalEpinephrine',s("The","process","in","which","the","secretion","of","epinephrine","from","nerve","endings","increases","the","rate","of","heart","muscle","contraction","."),4193765). assertion_content_comment('tOboGo_PositiveRegulationOfHeartRateByNeuronalNorepinephrine',s("The","process","in","which","the","secretion","of","norepinephrine","released","from","nerve","endings","increases","the","rate","of","heart","muscle","contraction","."),4193775). assertion_content_comment('tOboGo_PositiveRegulationOfHeartRateByNorepinephrine',s("The","process","in","which","the","secretion","of","norepinephrine","into","the","bloodstream","or","released","from","nerve","endings","increases","the","rate","of","heart","muscle","contraction","."),4003939). assertion_content_comment('tOboGo_PositiveRegulationOfHeartRateInvolvedInBaroreceptorResponseToDecreasedSystemicArterialBloodPressure',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","heart","contraction","as","a","result","of","the","baroreceptor","response","to","decreased","blood","pressure","."),3991903). assertion_content_comment('tOboGo_PositiveRegulationOfHeartRate',s("Any","process","that","activates","or","increases","the","frequency","or","rate","of","heart","contraction","."),3991589). assertion_content_comment('tOboGo_PositiveRegulationOfHeatDissipation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","heat","dissipation","."),4059765). assertion_content_comment('tOboGo_PositiveRegulationOfHeatGeneration',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","heat","generation","."),4059818). assertion_content_comment('tOboGo_PositiveRegulationOfHelicaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","helicase","."),4287168). assertion_content_comment('tOboGo_PositiveRegulationOfHematopoieticStemCellMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","hematopoietic","stem","cell","migration","."),4145444). assertion_content_comment('tOboGo_PositiveRegulationOfHemeBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","heme","."),4131395). assertion_content_comment('tOboGo_PositiveRegulationOfHemocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","hemocyte","differentiation","."),4072208). assertion_content_comment('tOboGo_PositiveRegulationOfHemocyteProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","hemocyte","proliferation",".","Hemocytes","are","blood","cells","associated","with","a","hemocoel","(","the","cavity","containing","most","of","the","major","organs","of","the","arthropod","body",")","that","are","involved","in","defense","and","clotting","of","hemolymph",",","but","not","involved","in","transport","of","oxygen",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4072132). assertion_content_comment('tOboGo_PositiveRegulationOfHemoglobinBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hemoglobin",",","an","oxygen","carrying",",","conjugated","protein","containing","four","heme","groups","and","globin","."),4099838). assertion_content_comment('tOboGo_PositiveRegulationOfHeparanSulfateProteoglycanBiosynthesisByPositiveRegulationOfEpimeraseActivity',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","heparan","sulfate","proteoglycan","biosynthesis","by","an","increase","in","epimerase","activity",".","This","epimerase","activity","catalyzes","the","reaction","that","converts","D-glucuronate","into","its","diastereoisomer","in","heparan","sulfate","."),4336059). assertion_content_comment('tOboGo_PositiveRegulationOfHeparanSulfateProteoglycanBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","heparan","sulfate","proteoglycan","biosynthesis",".","Heparan","sulfate","proteoglycan","biosynthetic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","heparan","sulfate","proteoglycan",",","a","glycosaminoglycan","with","repeat","unit","consisting","of","alternating","(","alpha1-","&","gt",";","4",")","-linked","hexuronic","acid","and","glucosamine","residues","."),4038359). assertion_content_comment('tOboGo_PositiveRegulationOfHepaticStellateCellActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","hepatic","stellate","cell","activation","."),4145892). assertion_content_comment('tOboGo_PositiveRegulationOfHepatocyteDifferentiation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","hepatocyte","differentiation","."),4136908). assertion_content_comment('tOboGo_PositiveRegulationOfHepatocyteGrowthFactorBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hepatocyte","growth","factor","."),4103469). assertion_content_comment('tOboGo_PositiveRegulationOfHepatocyteGrowthFactorProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","hepatocyte","growth","factor","production","."),4068296). assertion_content_comment('tOboGo_PositiveRegulationOfHepatocyteProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","hepatocyte","proliferation","."),4143402). assertion_content_comment('tOboGo_PositiveRegulationOfHeterochromatinFormation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","heterochromatin","formation","."),4060898). assertion_content_comment('tOboGo_PositiveRegulationOfHhTargetTranscriptionFactorActivity',s("Any","process","that","increases","the","activity","of","a","transcription","factor","that","activates","transcription","of","Hedgehog-target","genes","in","response","to","Smoothened","signaling",".","In","Drosophila",",","Cubitus","interruptus","(","Ci",")","is","the","only","identified","transcription","factor","so","far","in","the","Hedgehog","signaling","pathway",".","In","vertebrates",",","members","of","the","Gli","protein","family","are","activated","in","this","way",".","Activation","of","the","Gli/Ci","transcription","factor","is","distinct","from","its","stabilization",",","when","proteolytic","cleavage","is","inhibited","."),4016179). assertion_content_comment('tOboGo_PositiveRegulationOfHindgutContraction',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","muscle","contraction","of","the","hindgut",",","the","posterior","part","of","the","alimentary","canal",",","including","the","rectum",",","and","the","large","intestine","."),4117725). assertion_content_comment('tOboGo_PositiveRegulationOfHippoSignalingCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","hippo","signaling","."),4071354). assertion_content_comment('tOboGo_PositiveRegulationOfHistamineUptake',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","histamine","into","a","cell","."),4121710). assertion_content_comment('tOboGo_PositiveRegulationOfHistoneAcetylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","addition","of","an","acetyl","group","to","a","histone","protein","."),4072898). assertion_content_comment('tOboGo_PositiveRegulationOfHistoneDeacetylationAtCentromere',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","removal","of","acetyl","groups","from","histones","in","centromeric","DNA","."),4062811). assertion_content_comment('tOboGo_PositiveRegulationOfHistoneDeacetylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","removal","of","acetyl","groups","from","histones","."),4062792). assertion_content_comment('tOboGo_PositiveRegulationOfHistoneH4Acetylation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","histone","H4","acetylation",",","the","modification","of","histone","H4","by","the","addition","of","an","acetyl","group","."),4144149). assertion_content_comment('tOboGo_PositiveRegulationOfHistoneMethylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","covalent","addition","of","methyl","groups","to","histones","."),3975877). assertion_content_comment('tOboGo_PositiveRegulationOfHistoneModification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","covalent","alteration","of","a","histone","."),3975868). assertion_content_comment('tOboGo_PositiveRegulationOfHistonePhosphorylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","addition","of","one","or","more","phosphate","groups","to","a","histone","protein","."),4065996). assertion_content_comment('tOboGo_PositiveRegulationOfHistoneUbiquitination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","addition","of","a","ubiquitin","group","to","a","histone","protein","."),4065487). assertion_content_comment('tOboGo_PositiveRegulationOfHomeostaticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","homeostatic","process","."),4029803). assertion_content_comment('tOboGo_PositiveRegulationOfHomocysteineMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","homocysteine","."),4101507). assertion_content_comment('tOboGo_PositiveRegulationOfHormoneBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hormones","."),4028043). assertion_content_comment('tOboGo_PositiveRegulationOfHormoneMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","any","hormone","."),4028033). assertion_content_comment('tOboGo_PositiveRegulationOfHormoneSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","hormone","from","a","cell","or","group","of","cells","."),4054782). assertion_content_comment('tOboGo_PositiveRegulationOfHulleCellDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Hulle","cell","development",",","a","process","that","leads","to","the","formation","of","Hulle","cells",".","Hulle","cells","are","specialized","multinucleate","cells","that","originate","from","a","nest-like","aggregation","of","hyphae","during","sexual","development","and","serve","as","nurse","cells","to","the","developing","cleistothecium",",","or","fruiting","body","."),4132491). assertion_content_comment('tOboGo_PositiveRegulationOfHumoralImmuneResponseMediatedByCirculatingImmunoglobulin',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","humoral","immune","response","mediated","by","circulating","immunoglobulin","."),3999767). assertion_content_comment('tOboGo_PositiveRegulationOfHumoralImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","humoral","immune","response","."),3986425). assertion_content_comment('tOboGo_PositiveRegulationOfHydrogenPeroxideBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","hydrogen","peroxide","biosynthesis",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hydrogen","peroxide","(","H2O2",")",",","a","potentially","harmful","byproduct","of","aerobic","cellular","respiration","which","can","cause","damage","to","DNA","."),4024462). assertion_content_comment('tOboGo_PositiveRegulationOfHydrogenPeroxideMetabolicProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","hydrogen","peroxide","."),4024292). assertion_content_comment('tOboGo_PositiveRegulationOfHydrolaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","hydrolase","activity",",","the","catalysis","of","the","hydrolysis","of","various","bonds","."),4011520). assertion_content_comment('tOboGo_PositiveRegulationOfHypersensitivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","hypersensitivity","."),3983563). assertion_content_comment('tOboGo_PositiveRegulationOfHyphopodiumFormationOnOrNearHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","symbiont","hyphopodium","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146635). assertion_content_comment('tOboGo_PositiveRegulationOfHypoxanthineTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","hypoxanthine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083519). assertion_content_comment('tOboGo_PositiveRegulationOfIcosanoidSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","controlled","release","of","an","icosanoid","from","a","cell","or","group","of","cells","."),4054675). assertion_content_comment('tOboGo_PositiveRegulationOfImaginalDiscGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","imaginal","disc","growth","."),4087992). assertion_content_comment('tOboGo_PositiveRegulationOfImmatureTCellProliferationInThymus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","immature","T","cell","proliferation","in","the","thymus","."),4066361). assertion_content_comment('tOboGo_PositiveRegulationOfImmatureTCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","immature","T","cell","proliferation","."),4066337). assertion_content_comment('tOboGo_PositiveRegulationOfImmuneComplexClearanceByMonocytesAndMacrophages',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","process","of","immune","complex","clearance","by","monocytes","or","macrophages","."),4151869). assertion_content_comment('tOboGo_PositiveRegulationOfImmuneEffectorProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","immune","effector","process","."),3983608). assertion_content_comment('tOboGo_PositiveRegulationOfImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","immune","response",",","the","immunological","reaction","of","an","organism","to","an","immunogenic","stimulus","."),3983538). assertion_content_comment('tOboGo_PositiveRegulationOfImmuneResponseToTumorCell',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","immune","response","to","tumor","cell","."),4000174). assertion_content_comment('tOboGo_PositiveRegulationOfImmuneSystemProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","immune","system","process","."),3983528). assertion_content_comment('tOboGo_PositiveRegulationOfImmunoglobulinBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","immunoglobulin","biosynthesis","."),3995593). assertion_content_comment('tOboGo_PositiveRegulationOfImmunoglobulinMediatedImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","immunoglobulin","mediated","immune","response","."),3983677). assertion_content_comment('tOboGo_PositiveRegulationOfImmunoglobulinProductionInMucosalTissue',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","immunoglobulin","production","in","mucosal","tissue","."),4145053). assertion_content_comment('tOboGo_PositiveRegulationOfImmunoglobulinProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","immunoglobulin","production","."),3995518). assertion_content_comment('tOboGo_PositiveRegulationOfImmunoglobulinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","immunoglobulins","from","a","cell","or","group","of","cells","."),4119208). assertion_content_comment('tOboGo_PositiveRegulationOfImmunologicalSynapseFormation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","immunological","synapse","formation","."),4144912). assertion_content_comment('tOboGo_PositiveRegulationOfInclusionBodyAssembly',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","inclusion","body","assembly",".","Inclusion","body","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","inclusion","body","."),4151881). assertion_content_comment('tOboGo_PositiveRegulationOfInductionOfApoptosisInResponseToChemicalStimulus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","induction","of","apoptosis","in","response","to","chemical","stimulus","."),4145662). assertion_content_comment('tOboGo_PositiveRegulationOfInfectionCushionFormationOnOrNearHost',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","symbiont","infection","cushion","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146589). assertion_content_comment('tOboGo_PositiveRegulationOfInflammatoryResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","inflammatory","response","."),3983488). assertion_content_comment('tOboGo_PositiveRegulationOfInflammatoryResponseToAntigenicStimulus',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","an","inflammatory","response","to","an","antigenic","stimulus","."),3983545). assertion_content_comment('tOboGo_PositiveRegulationOfInhibinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","inhibin","from","a","cell","or","group","of","cells","."),4056181). assertion_content_comment('tOboGo_PositiveRegulationOfInitiationOfAcetateCatabolicProcessByAcetate',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","activation",",","by","acetate",",","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate","."),4091149). assertion_content_comment('tOboGo_PositiveRegulationOfInitiationOfTCellReceptorSignaling',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","initiation","of","T","cell","receptor","signaling","."),4052423). assertion_content_comment('tOboGo_PositiveRegulationOfInnateImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","innate","immune","response",",","the","organism","'","s","first","line","of","defense","against","infection","."),3986401). assertion_content_comment('tOboGo_PositiveRegulationOfInosineTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","inosine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083442). assertion_content_comment('tOboGo_PositiveRegulationOfInositolPhosphateBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","inositol","phosphate","biosynthesis",".","Inositol","phosphate","biosynthetic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","inositol","phosphate",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","with","one","or","more","phosphate","groups","attached","."),4063798). assertion_content_comment('tOboGo_PositiveRegulationOfInositolTrisphosphateBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","inositol","trisphosphate","."),4063801). assertion_content_comment('tOboGo_PositiveRegulationOfInsulinReceptorSignalingPathway',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","insulin","receptor","signaling","."),4098883). assertion_content_comment('tOboGo_PositiveRegulationOfInsulinSecretionInvolvedInCellularResponseToGlucoseStimulus',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","insulin","that","contributes","to","the","response","of","a","cell","to","glucose","."),4081390). assertion_content_comment('tOboGo_PositiveRegulationOfInsulinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","insulin","."),4057089). assertion_content_comment('tOboGo_PositiveRegulationOfIntegrinActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","integrin","activation","."),4063623). assertion_content_comment('tOboGo_PositiveRegulationOfIntegrinBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","integrins","."),4090751). assertion_content_comment('tOboGo_PositiveRegulationOfIntermediateFilamentDepolymerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","intermediate","filament","depolymerization","."),4061665). assertion_content_comment('tOboGo_PositiveRegulationOfIntermediateFilamentPolymerizationAndOrDepolymerization',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","intermediate","filament","polymerization","and/or","depolymerization","."),4298204). assertion_content_comment('tOboGo_PositiveRegulationOfIntermediateFilamentPolymerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","intermediate","filament","polymerization","."),4051437). assertion_content_comment('tOboGo_PositiveRegulationOfIntermediateMesodermalCellFateDetermination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","intermediate","mesoderm","cell","fate","determination","."),4102174). assertion_content_comment('tOboGo_PositiveRegulationOfIntermediateMesodermalCellFateSpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","intermediate","mesoderm","cell","fate","specification","."),4102056). assertion_content_comment('tOboGo_PositiveRegulationOfIntestinalCholesterolAbsorption',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","uptake","of","cholesterol","into","the","blood","by","absorption","from","the","intestine","."),4090969). assertion_content_comment('tOboGo_PositiveRegulationOfIntestinalEpithelialStructureMaintenance',s("Any","process","the","increases","the","rate",",","frequency","or","extent","of","intestinal","epithelial","structure","maintenance",",","a","tissue","homeostatic","process","required","for","the","maintenance","of","the","structure","of","the","intestinal","epithelium","."),4110807). assertion_content_comment('tOboGo_PositiveRegulationOfIntracellularCholesterolTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","cholesterol","within","cells","."),4056573). assertion_content_comment('tOboGo_PositiveRegulationOfIntracellularLipidTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","lipids","within","cells","."),4056533). assertion_content_comment('tOboGo_PositiveRegulationOfIntracellularProteinKinaseCascade',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","a","series","of","reactions",",","mediated","by","protein","kinases",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4024542). assertion_content_comment('tOboGo_PositiveRegulationOfIntracellularProteinTransport',s("Any","process","that","decreases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","proteins","within","cells","."),4020173). assertion_content_comment('tOboGo_PositiveRegulationOfIntracellularSterolTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","sterols","within","cells","."),4056553). assertion_content_comment('tOboGo_PositiveRegulationOfIntracellularTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","within","cells","."),4020146). assertion_content_comment('tOboGo_PositiveRegulationOfInvasiveGrowthInResponseToGlucoseLimitation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","invasive","growth","in","response","to","glucose","limitation","."),4140831). assertion_content_comment('tOboGo_PositiveRegulationOfIonTransmembraneTransporterActivity',s("Any","process","that","activates","or","increases","the","activity","of","an","ion","transporter","."),4160423). assertion_content_comment('tOboGo_PositiveRegulationOfIonTransmembraneTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","ions","from","one","side","of","a","membrane","to","the","other","."),4073279). assertion_content_comment('tOboGo_PositiveRegulationOfIonTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","charged","atoms","or","small","charged","molecules","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990807). assertion_content_comment('tOboGo_PositiveRegulationOfIridophoreDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","iridophore","differentiation","."),4100097). assertion_content_comment('tOboGo_PositiveRegulationOfIronIonTransmembraneTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","iron","ions","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4073368). assertion_content_comment('tOboGo_PositiveRegulationOfIronIonTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","iron","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4073308). assertion_content_comment('tOboGo_PositiveRegulationOfIsomeraseActivity',s("Any","process","that","increases","the","activity","of","an","isomerase",".","An","isomerase","catalyzes","the","geometric","or","structural","changes","within","one","molecule",".","Isomerase","is","the","systematic","name","for","any","enzyme","of","EC","class","5","."),4172480). assertion_content_comment('tOboGo_PositiveRegulationOfIsoprenoidMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","isoprenoid","."),4030947). assertion_content_comment('tOboGo_PositiveRegulationOfIsotypeSwitching',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","isotype","switching","."),4090689). assertion_content_comment('tOboGo_PositiveRegulationOfIsotypeSwitchingToIgAIsotypes',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgA","isotypes","."),4103884). assertion_content_comment('tOboGo_PositiveRegulationOfIsotypeSwitchingToIgDIsotypes',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgD","isotypes","."),4103625). assertion_content_comment('tOboGo_PositiveRegulationOfIsotypeSwitchingToIgEIsotypes',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgE","isotypes","."),4103847). assertion_content_comment('tOboGo_PositiveRegulationOfIsotypeSwitchingToIgGIsotypes',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgG","isotypes","."),4103686). assertion_content_comment('tOboGo_PositiveRegulationOfJNKCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","JNK","cascade","."),4098177). assertion_content_comment('tOboGo_PositiveRegulationOfJUNKinaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","JUN","kinase","activity","."),4016622). assertion_content_comment('tOboGo_PositiveRegulationOfJuvenileHormoneBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","juvenile","hormone","."),4092516). assertion_content_comment('tOboGo_PositiveRegulationOfJuvenileHormoneCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","juvenile","hormone","."),4092427). assertion_content_comment('tOboGo_PositiveRegulationOfJuvenileHormoneMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","juvenile","hormone","."),4089748). assertion_content_comment('tOboGo_PositiveRegulationOfJuvenileHormoneSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","juvenile","hormone","."),4092461). assertion_content_comment('tOboGo_PositiveRegulationOfKeratinocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","keratinocyte","differentiation","."),4087252). assertion_content_comment('tOboGo_PositiveRegulationOfKeratinocyteMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","keratinocyte","migration","."),4118873). assertion_content_comment('tOboGo_PositiveRegulationOfKeratinocyteProliferation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","keratinocyte","proliferation",".","Keratinocyte","proliferation","is","the","multiplication","or","reproduction","of","keratinocytes",",","resulting","in","the","expansion","of","a","cell","population","."),4036685). assertion_content_comment('tOboGo_PositiveRegulationOfKidneyDevelopment',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","kidney","development",".","Kidney","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","kidney","over","time",",","from","its","formation","to","the","mature","structure",".","The","kidney","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4123947). assertion_content_comment('tOboGo_PositiveRegulationOfKidneySmoothMuscleCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","kidney","smooth","muscle","cell","differentiation","."),4142859). assertion_content_comment('tOboGo_PositiveRegulationOfKillingOfCellsOfOtherOrganism',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","killing","by","an","organism","of","cells","in","another","organism","."),3985935). assertion_content_comment('tOboGo_PositiveRegulationOfKinaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","substrate","molecule","."),3972585). assertion_content_comment('tOboGo_PositiveRegulationOfKininCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","the","kinin","cascade","."),3992171). assertion_content_comment('tOboGo_PositiveRegulationOfLamellipodiumAssembly',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","formation","of","a","lamellipodium",",","a","thin","sheetlike","extension","of","the","surface","of","a","migrating","cell","."),4028522). assertion_content_comment('tOboGo_PositiveRegulationOfLamellipodiumMorphogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lamellipodium","morphogenesis","."),4142476). assertion_content_comment('tOboGo_PositiveRegulationOfLamellocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lamellocyte","differentiation",".","Lamellocytes","differentiate","massively","in","the","lymph","glands","after","parasitization","and","are","large","flat","cells","devoted","to","encapsulation","of","invaders","too","large","to","be","phagocytosed","by","plasmatocytes","."),4072217). assertion_content_comment('tOboGo_PositiveRegulationOfLarvalSalivaryGlandBoundarySpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","salivary","gland","determination","in","a","larval","organism","."),4091372). assertion_content_comment('tOboGo_PositiveRegulationOfLateralMesodermalCellFateDetermination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lateral","mesoderm","cell","fate","determination","."),4102398). assertion_content_comment('tOboGo_PositiveRegulationOfLateralMesodermalCellFateSpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lateral","mesoderm","cell","fate","specification","."),4102415). assertion_content_comment('tOboGo_PositiveRegulationOfLateralPseudopodiumAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","assembly","of","pseudopodia","from","the","lateral","side","of","the","cell","."),4059531). assertion_content_comment('tOboGo_PositiveRegulationOfLateStripeMelanocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","late","stripe","melanocyte","differentiation","."),4100654). assertion_content_comment('tOboGo_PositiveRegulationOfLeafletFormationByAuxinMediatedSignalingPathway',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","leaflet","formation","as","a","result","of","the","series","of","molecular","signals","generated","in","response","to","detection","of","auxin","."),4149638). assertion_content_comment('tOboGo_PositiveRegulationOfLeucophoreDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","leucophore","differentiation","."),4105003). assertion_content_comment('tOboGo_PositiveRegulationOfLeukocyteActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","leukocyte","activation","."),3989200). assertion_content_comment('tOboGo_PositiveRegulationOfLeukocyteApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","leukocyte","apoptosis","."),3999397). assertion_content_comment('tOboGo_PositiveRegulationOfLeukocyteChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","leukocyte","chemotaxis","."),3998217). assertion_content_comment('tOboGo_PositiveRegulationOfLeukocyteDegranulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","leukocyte","degranulation","."),4093526). assertion_content_comment('tOboGo_PositiveRegulationOfLeukocyteMediatedCytotoxicity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","leukocyte","mediated","cytotoxicity","."),3984375). assertion_content_comment('tOboGo_PositiveRegulationOfLeukocyteMediatedImmunity',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","leukocyte","mediated","immunity","."),3983617). assertion_content_comment('tOboGo_PositiveRegulationOfLeukocyteMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","leukocyte","migration","."),3997894). assertion_content_comment('tOboGo_PositiveRegulationOfLeukocyteProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","leukocyte","proliferation","."),4062007). assertion_content_comment('tOboGo_PositiveRegulationOfLeukotrieneProductionInvolvedInInflammatoryResponse',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","synthesis","or","release","of","any","leukotriene","following","a","stimulus","as","part","of","an","inflammatory","response","."),4084390). assertion_content_comment('tOboGo_PositiveRegulationOfLigaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ligase","activity",",","the","catalysis","of","the","ligation","of","two","substances","with","concomitant","breaking","of","a","diphosphate","linkage",",","usually","in","a","nucleoside","triphosphate","."),4012392). assertion_content_comment('tOboGo_PositiveRegulationOfLipaseActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","lipase","activity",",","the","hydrolysis","of","a","lipid","or","phospholipid","."),4049038). assertion_content_comment('tOboGo_PositiveRegulationOfLipidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","lipids","."),4030356). assertion_content_comment('tOboGo_PositiveRegulationOfLipidCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lipids","."),4037869). assertion_content_comment('tOboGo_PositiveRegulationOfLipidKinaseActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","lipid","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","simple","or","complex","lipid","."),4155537). assertion_content_comment('tOboGo_PositiveRegulationOfLipidMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","lipids","."),4030346). assertion_content_comment('tOboGo_PositiveRegulationOfLipidStorage',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","lipid","storage",".","Lipid","storage","is","the","accumulation","and","maintenance","in","cells","or","tissues","of","lipids",",","compounds","soluble","in","organic","solvents","but","insoluble","or","sparingly","soluble","in","aqueous","solvents",".","Lipid","reserves","can","be","accumulated","during","early","developmental","stages","for","mobilization","and","utilization","at","later","stages","of","development","."),4037505). assertion_content_comment('tOboGo_PositiveRegulationOfLipidTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","lipids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4024806). assertion_content_comment('tOboGo_PositiveRegulationOfLipoproteinLipaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","the","enzyme","lipoprotein","lipase","."),4279165). assertion_content_comment('tOboGo_PositiveRegulationOfLipoproteinMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","lipoproteins",",","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids","."),4101233). assertion_content_comment('tOboGo_PositiveRegulationOfLipoproteinParticleClearance',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","lipoprotein","particle","clearance",".","Lipoprotein","particle","clearance","is","the","process","in","which","a","lipoprotein","particle","is","removed","from","the","blood","via","receptor-mediated","endocytosis","and","its","constituent","parts","degraded","."),4035762). assertion_content_comment('tOboGo_PositiveRegulationOfLocomotionInvolvedInLocomotoryBehavior',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","the","self-propelled","movement","of","a","cell","or","organism","from","one","location","to","another","in","a","behavioral","context",";","the","aspect","of","locomotory","behavior","having","to","do","with","movement","."),4150567). assertion_content_comment('tOboGo_PositiveRegulationOfLocomotion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","locomotion","of","a","cell","or","organism","."),3997851). assertion_content_comment('tOboGo_PositiveRegulationOfLuteinizingHormoneSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","luteinizing","hormone","."),4063032). assertion_content_comment('tOboGo_PositiveRegulationOfLyaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lyase","activity",",","the","catalysis","of","the","cleavage","of","C-C",",","C-O",",","C-N","and","other","bonds","by","other","means","than","by","hydrolysis","or","oxidation",",","or","conversely","adding","a","group","to","a","double","bond","."),4153203). assertion_content_comment('tOboGo_PositiveRegulationOfLymphocyteActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lymphocyte","activation","."),3989211). assertion_content_comment('tOboGo_PositiveRegulationOfLymphocyteAnergy',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","lymphocyte","anergy","."),3998300). assertion_content_comment('tOboGo_PositiveRegulationOfLymphocyteApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lymphocyte","death","by","apoptosis","."),3999400). assertion_content_comment('tOboGo_PositiveRegulationOfLymphocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lymphocyte","differentiation","."),3989219). assertion_content_comment('tOboGo_PositiveRegulationOfLymphocyteMediatedImmunity',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","lymphocyte","mediated","immunity","."),3983628). assertion_content_comment('tOboGo_PositiveRegulationOfLymphocyteMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","lymphocyte","migration","."),4036499). assertion_content_comment('tOboGo_PositiveRegulationOfLymphocyteProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","lymphocyte","proliferation","."),4062027). assertion_content_comment('tOboGo_PositiveRegulationOfLymphotoxinABiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","cytokine","lymphotoxin","A","."),4093976). assertion_content_comment('tOboGo_PositiveRegulationOfLymphotoxinAProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","lymphotoxin","A","production","."),4068928). assertion_content_comment('tOboGo_PositiveRegulationOfMacroautophagy',s("Any","process",",","such","as","recognition","of","nutrient","depletion",",","that","activates","or","increases","the","rate","of","macroautophagy","to","bring","cytosolic","macromolecules","to","the","vacuole/lysosome","for","degradation","."),4034041). assertion_content_comment('tOboGo_PositiveRegulationOfMacromoleculeBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","macromolecule",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3995590). assertion_content_comment('tOboGo_PositiveRegulationOfMacromoleculeMetabolicProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","macromolecules",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3975298). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageActivation',s("Any","process","that","stimulates",",","induces","or","increases","the","rate","of","macrophage","activation","."),4094082). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","macrophage","antigen","processing","and","presentation","."),3994552). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","macrophage","apoptosis","."),4138395). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageChemotaxis',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","macrophage","chemotaxis",".","Macrophage","chemotaxis","is","the","movement","of","a","macrophage","in","response","to","an","external","stimulus","."),4025036). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageCytokineProduction',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","macrophage","cytokine","production",".","Macrophage","cytokine","production","is","the","appearance","of","a","chemokine","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4114239). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageDerivedFoamCellDifferentiation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","macrophage","derived","foam","cell","differentiation",".","Macrophage","derived","foam","cell","differentiation","is","the","process","in","which","a","macrophage","acquires","the","specialized","features","of","a","foam","cell",".","A","foam","cell","is","a","type","of","cell","containing","lipids","in","small","vacuoles","and","typically","seen","in","atherosclerotic","lesions",",","as","well","as","other","conditions","."),4024664). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","macrophage","differentiation","."),4087712). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageFusion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","macrophage","fusion","."),4075757). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageInflammatoryProtein1AlphaProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","macrophage","inflammatory","protein","1","alpha","."),4130112). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageMigrationInhibitoryFactorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","macrophage","migration","inhibitory","factor","signaling","pathway","."),4142356). assertion_content_comment('tOboGo_PositiveRegulationOfMacrophageToleranceInduction',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","B","cell","tolerance","induction","."),4034992). assertion_content_comment('tOboGo_PositiveRegulationOfMaintenanceOfBipolarCellPolarityRegulatingCellShape',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","maintenance","of","bipolar","cell","polarity","regulating","cell","shape","."),4133712). assertion_content_comment('tOboGo_PositiveRegulationOfMaintenanceOfMeioticSisterChromatidCohesion',s("Any","process","that","increases","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","during","a","meiotic","cell","cycle","."),4076620). assertion_content_comment('tOboGo_PositiveRegulationOfMaintenanceOfMitoticSisterChromatidCohesion',s("Any","process","that","increases","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","during","a","mitotic","cell","cycle","."),4076048). assertion_content_comment('tOboGo_PositiveRegulationOfMaintenanceOfSisterChromatidCohesion',s("Any","process","that","increases","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","."),4076033). assertion_content_comment('tOboGo_PositiveRegulationOfMaleGermCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","male","germ","cell","proliferation","."),4140346). assertion_content_comment('tOboGo_PositiveRegulationOfMaleGonadDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","male","gonad","development","."),4139417). assertion_content_comment('tOboGo_PositiveRegulationOfMalePigmentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","males","."),4104413). assertion_content_comment('tOboGo_PositiveRegulationOfMammaryGlandEpithelialCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","mammary","gland","epithelial","cell","proliferation","."),4063471). assertion_content_comment('tOboGo_PositiveRegulationOfMammaryStemCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mammary","stem","cell","proliferation","."),4138426). assertion_content_comment('tOboGo_PositiveRegulationOfMAPKinaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","MAP","kinase","activity","."),3972602). assertion_content_comment('tOboGo_PositiveRegulationOfMAPKKKCascadeByFibroblastGrowthFactorReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","resulting","in","an","increase","in","the","rate","or","frequency","of","a","MAPKKK","cascade","."),4155047). assertion_content_comment('tOboGo_PositiveRegulationOfMAPKKKCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","MAPK","cascade","."),4070182). assertion_content_comment('tOboGo_PositiveRegulationOfMastCellActivationInvolvedInImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","mast","cell","activation","as","part","of","an","immune","response","."),4065241). assertion_content_comment('tOboGo_PositiveRegulationOfMastCellActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","mast","cell","activation","."),4065230). assertion_content_comment('tOboGo_PositiveRegulationOfMastCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","mast","cell","apoptosis","."),4065125). assertion_content_comment('tOboGo_PositiveRegulationOfMastCellChemotaxis',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","mast","cell","chemotaxis",".","Mast","cell","chemotaxis","is","the","movement","of","a","mast","cell","in","response","to","an","external","stimulus","."),4110473). assertion_content_comment('tOboGo_PositiveRegulationOfMastCellCytokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","mast","cell","cytokine","production","."),4068982). assertion_content_comment('tOboGo_PositiveRegulationOfMastCellDegranulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mast","cell","degranulation","."),4093695). assertion_content_comment('tOboGo_PositiveRegulationOfMastCellDifferentiation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","mast","cell","differentiation",",","the","process","in","which","a","relatively","unspecialized","myeloid","precursor","cell","acquires","the","specialized","features","of","a","mast","cell",".","A","mast","cell","is","a","cell","that","is","found","in","almost","all","tissues","containing","numerous","basophilic","granules","and","capable","of","releasing","large","amounts","of","histamine","and","heparin","upon","activation","."),4114977). assertion_content_comment('tOboGo_PositiveRegulationOfMastCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","mast","cell","proliferation","."),4130483). assertion_content_comment('tOboGo_PositiveRegulationOfMatingTypeSwitching',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mating","type","switching","."),4060865). assertion_content_comment('tOboGo_PositiveRegulationOfMatureBCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","mature","B","cell","apoptosis","."),3999837). assertion_content_comment('tOboGo_PositiveRegulationOfMechanoreceptorDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mechanoreceptor","differentiation","."),4086998). assertion_content_comment('tOboGo_PositiveRegulationOfMegakaryocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","megakaryocyte","differentiation","."),4087763). assertion_content_comment('tOboGo_PositiveRegulationOfMeiosisI',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","meiosis","I",",","a","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","first","phase","of","meiosis",",","in","which","cells","divide","and","homologous","chromosomes","are","paired","and","segregated","from","each","other",",","producing","two","daughter","cells","."),4114165). assertion_content_comment('tOboGo_PositiveRegulationOfMeiosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","meiosis","."),4036877). assertion_content_comment('tOboGo_PositiveRegulationOfMeioticCellCycle',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","progression","through","the","meiotic","cell","cycle","."),4118335). assertion_content_comment('tOboGo_PositiveRegulationOfMelaninBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","melanin","."),4104462). assertion_content_comment('tOboGo_PositiveRegulationOfMelanizationDefenseResponse',s("Any","process","that","increases","the","rate","or","extent","of","the","melanization","defense","response","during","injury","or","invasion","."),4072457). assertion_content_comment('tOboGo_PositiveRegulationOfMelanocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","melanocyte","differentiation","."),4086965). assertion_content_comment('tOboGo_PositiveRegulationOfMembranePotential',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","or","extent","of","a","membrane","potential",",","the","electric","potential","existing","across","any","membrane","arising","from","charges","in","the","membrane","itself","and","from","the","charges","present","in","the","media","on","either","side","of","the","membrane","."),4171905). assertion_content_comment('tOboGo_PositiveRegulationOfMembraneProteinEctodomainProteolysis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","membrane","protein","ectodomain","peptidolysis","."),4119272). assertion_content_comment('tOboGo_PositiveRegulationOfMemoryTCellActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","memory","T","cell","activation","."),4144263). assertion_content_comment('tOboGo_PositiveRegulationOfMemoryTCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","memory","T","cell","differentiation","."),4095736). assertion_content_comment('tOboGo_PositiveRegulationOfMesenchymalCellProliferation',s("The","process","of","activating","or","increasing","the","rate","or","extent","of","mesenchymal","cell","proliferation",".","Mesenchymal","cells","are","loosely","organized","embryonic","cells","."),3990420). assertion_content_comment('tOboGo_PositiveRegulationOfMesenchymalStemCellApoptosisInvolvedInMesonephricNephronMorphogenesis',s("Any","process","that","increases","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephron","in","the","mesonephros","."),4134789). assertion_content_comment('tOboGo_PositiveRegulationOfMesenchymalStemCellApoptosisInvolvedInMetanephricNephronMorphogenesis',s("Any","process","that","increases","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephronin","the","metanephros","."),4124648). assertion_content_comment('tOboGo_PositiveRegulationOfMesenchymalStemCellApoptosisInvolvedInNephronMorphogenesis',s("Any","process","that","increases","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephron","."),4123615). assertion_content_comment('tOboGo_PositiveRegulationOfMesenchymalToEpithelialTransitionInvolvedInMesonephrosMorphogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mesenchymal","to","epithelial","transition","involved","in","mesonephros","morphogenesis","."),4138275). assertion_content_comment('tOboGo_PositiveRegulationOfMesenchymalToEpithelialTransitionInvolvedInMetanephrosMorphogenesis',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","that","will","contribute","to","the","shaping","of","the","metanephros","."),4122582). assertion_content_comment('tOboGo_PositiveRegulationOfMesodermalCellFateDetermination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mesoderm","cell","fate","determination","."),4102165). assertion_content_comment('tOboGo_PositiveRegulationOfMesodermalCellFateSpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mesoderm","cell","fate","specification","."),4102047). assertion_content_comment('tOboGo_PositiveRegulationOfMesodermalToMesenchymalTransitionInvolvedInGastrulation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","epithelial","to","mesenchymal","transition",".","Epithelial","to","mesenchymal","transition","where","a","mesodermal","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","as","part","of","the","process","of","gastrulation","."),4111092). assertion_content_comment('tOboGo_PositiveRegulationOfMesodermDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mesoderm","development","."),4143063). assertion_content_comment('tOboGo_PositiveRegulationOfMesonephricGlomerularMesangialCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mesonephric","glomerular","mesangial","cell","proliferation","."),4138228). assertion_content_comment('tOboGo_PositiveRegulationOfMesonephricGlomerulusDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mesonephric","glomerulus","development","."),4138250). assertion_content_comment('tOboGo_PositiveRegulationOfMesonephrosDevelopment',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","mesonephros","development",".","Mesonephros","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephros","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4134784). assertion_content_comment('tOboGo_PositiveRegulationOfMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","within","a","cell","or","an","organism","."),3975288). assertion_content_comment('tOboGo_PositiveRegulationOfMetalloenzymeActivity',s("Any","process","that","activates",",","maintains","or","increases","the","rate","activity","of","a","metalloenzyme",".","A","metalloenzyme","is","any","enzyme","that","contains","metal","."),4332336). assertion_content_comment('tOboGo_PositiveRegulationOfMetanephricCapMesenchymalCellProliferation',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","metanephric","cap","mesenchymal","cell","proliferation",".","Metanephric","cap","mesenchymal","cell","proliferation","is","the","multiplication","or","reproduction","of","metanephric","cap","mesenchymal","cells",",","resulting","in","the","expansion","of","the","cell","population",".","A","metanephric","cap","mesenchymal","cell","is","a","mesenchymal","cell","that","has","condensed","with","other","mesenchymal","cells","surrounding","the","ureteric","bud","tip","."),4150453). assertion_content_comment('tOboGo_PositiveRegulationOfMetanephricDCTCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","metanephric","DCT","cell","differentiation","."),4144430). assertion_content_comment('tOboGo_PositiveRegulationOfMetanephricGlomerularVisceralEpithelialCellDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","metanephric","glomerular","visceral","epithelial","cell","development","."),4145485). assertion_content_comment('tOboGo_PositiveRegulationOfMetanephricGlomerulusDevelopment',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","metanephric","glomerulus","development",",","the","progression","of","the","metanephric","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","metanephric","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney",",","or","metanephros","."),4124549). assertion_content_comment('tOboGo_PositiveRegulationOfMetanephricMesenchymalCellMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","metanephric","mesenchymal","cell","migration","."),4144544). assertion_content_comment('tOboGo_PositiveRegulationOfMetanephrosDevelopment',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","metanephros","development",".","Metanephros","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephros","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4123966). assertion_content_comment('tOboGo_PositiveRegulationOfMetulaDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","metula","development",",","a","process","that","leads","to","the","formation","of","metulae",".","Metulae","are","elongated","mononucleate","cells","that","bud","from","the","surface","of","the","conidiophore","tip","."),4132584). assertion_content_comment('tOboGo_PositiveRegulationOfMHCClassIBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","MHC","class","I","."),4085919). assertion_content_comment('tOboGo_PositiveRegulationOfMHCClassIIBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","MHC","class","II","."),4085876). assertion_content_comment('tOboGo_PositiveRegulationOfMicrogliaDifferentiation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","microglia","differentiation",",","the","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","microglial","cell","."),4036265). assertion_content_comment('tOboGo_PositiveRegulationOfMicrotubuleDepolymerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","microtubule","depolymerization","."),4062558). assertion_content_comment('tOboGo_PositiveRegulationOfMicrotubuleMotorActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","microtubule","motor","activity","."),4155713). assertion_content_comment('tOboGo_PositiveRegulationOfMicrotubuleNucleation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","microtubule","nucleation",".","Microtubule","nucleation","is","the","'","de","novo","'","formation","of","a","microtubule",",","in","which","tubulin","heterodimers","form","metastable","oligomeric","aggregates",",","some","of","which","go","on","to","support","formation","of","a","complete","microtubule",".","Microtubule","nucleation","usually","occurs","from","a","specific","site","within","a","cell","."),4149992). assertion_content_comment('tOboGo_PositiveRegulationOfMicrotubulePolymerizationOrDepolymerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","microtubule","polymerization","or","depolymerization","."),4062548). assertion_content_comment('tOboGo_PositiveRegulationOfMicrotubulePolymerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","microtubule","polymerization","."),4062646). assertion_content_comment('tOboGo_PositiveRegulationOfMiRNACatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","miRNA","catabolic","process","."),4144039). assertion_content_comment('tOboGo_PositiveRegulationOfMiRNAMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","miRNA","metabolic","process","."),4144035). assertion_content_comment('tOboGo_PositiveRegulationOfMismatchRepair',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mismatch","repair","."),4055563). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialDepolarization',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","change","in","the","membrane","potential","of","the","mitochondria","from","negative","to","positive","."),4120205). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialDNAReplication',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","process","in","which","new","strands","of","DNA","are","synthesized","in","the","mitochondrion","."),4152083). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialFission',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","mitochondrial","fission",".","Mitochondrial","fission","is","the","division","of","a","mitochondrion","within","a","cell","to","form","two","or","more","separate","mitochondrial","compartments","."),4149136). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialFusion',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","merging","of","two","or","more","mitochondria","within","a","cell","to","form","a","single","compartment","."),4028727). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialMembranePermeability',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","passage","or","uptake","of","molecules","by","the","mitochondrial","membrane","."),4381321). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialMembranePotential',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","or","extent","of","a","mitochondrial","membrane","potential",",","the","electric","potential","existing","across","any","mitochondrial","membrane","arising","from","charges","in","the","membrane","itself","and","from","the","charges","present","in","the","media","on","either","side","of","the","membrane","."),4336080). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialRNACatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","catabolism","in","the","mitochondrion","of","RNA","transcribed","from","the","mitochondrial","genome","."),3979720). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialTranslationalInitiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","process","preceding","formation","of","the","peptide","bond","between","the","first","two","amino","acids","of","a","protein","in","a","mitochondrion","."),4133347). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialTranslationInResponseToStress',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mitochondrial","translation","as","a","result","of","a","stimulus","indicating","the","organism","is","under","stress","."),4336008). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrialTranslation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","proteins","by","the","translation","of","mRNA","in","a","mitochondrion","."),4133187). assertion_content_comment('tOboGo_PositiveRegulationOfMitochondrionOrganization',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","mitochondrion","."),4028723). assertion_content_comment('tOboGo_PositiveRegulationOfMitosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mitosis","."),4012249). assertion_content_comment('tOboGo_PositiveRegulationOfMitoticCellCycleEmbryonic',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","progression","through","the","embryonic","mitotic","cell","cycle","."),4091940). assertion_content_comment('tOboGo_PositiveRegulationOfMitoticCellCycle',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","progression","through","the","mitotic","cell","cycle","."),4035514). assertion_content_comment('tOboGo_PositiveRegulationOfMitoticCellCycleSpindleAssemblyCheckpoint',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","mitotic","cell","cycle","spindle","assembly","checkpoint",",","a","cell","cycle","checkpoint","that","delays","the","metaphase/anaphase","transition","of","a","mitotic","nuclear","division","until","the","spindle","is","correctly","assembled","and","chromosomes","are","attached","to","the","spindle","."),4151829). assertion_content_comment('tOboGo_PositiveRegulationOfMitoticCentrosomeSeparation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","centrosome","separation","."),4098703). assertion_content_comment('tOboGo_PositiveRegulationOfMitoticMetaphaseAnaphaseTransition',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","mitotic","metaphase","to","anaphase","transition","."),4012258). assertion_content_comment('tOboGo_PositiveRegulationOfMitoticPrometaphase',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mitotic","prometaphase",",","the","stage","following","prophase","in","mitosis","(","in","higher","eukaryotes",")","during","which","the","nuclear","envelope","is","disrupted","and","breaks","into","membrane","vesicles",",","and","the","spindle","microtubules","enter","the","nuclear","region","."),4082946). assertion_content_comment('tOboGo_PositiveRegulationOfMitoticRecombination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","recombination","during","mitosis","."),4055240). assertion_content_comment('tOboGo_PositiveRegulationOfMolecularFunctionEpigenetic',s("Any","heritable","epigenetic","process","that","increases","the","frequency",",","rate","or","extent","of","protein","function","by","self-perpetuating","conformational","conversions","of","normal","proteins","in","healthy","cells",".","This","is","distinct","from",",","though","mechanistically","analogous","to",",","disease","states","associated","with","prion","propagation","and","amyloidogenesis",".","A","single","protein",",","if","it","carries","a","glutamine/asparagine-rich","(","'","prion","'",")","domain",",","can","sometimes","stably","exist","in","at","least","two","distinct","physical","states",",","each","associated","with","a","different","phenotype",";","propagation","of","one","of","these","traits","is","achieved","by","a","self-perpetuating","change","in","the","protein","from","one","form","to","the","other",",","mediated","by","conformational","changes","in","the","glutamine/asparagine-rich","domain",".","Prion","domains","are","both","modular","and","transferable","to","other","proteins",",","on","which","they","can","confer","a","heritable","epigenetic","alteration","of","function",";","existing","bioinformatics","data","indicate","that","they","are","rare","in","non-eukarya",",","but","common","in","eukarya","."),4298148). assertion_content_comment('tOboGo_PositiveRegulationOfMolecularFunction',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","a","molecular","function",",","an","elemental","biological","activity","occurring","at","the","molecular","level",",","such","as","catalysis","or","binding","."),3972565). assertion_content_comment('tOboGo_PositiveRegulationOfMonocyteAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","monocyte","antigen","processing","and","presentation","."),3994602). assertion_content_comment('tOboGo_PositiveRegulationOfMonocyteChemotaxis',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","monocyte","chemotaxis","."),4149871). assertion_content_comment('tOboGo_PositiveRegulationOfMonocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","monocyte","differentiation","."),4087326). assertion_content_comment('tOboGo_PositiveRegulationOfMonocyteExtravasation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","monocyte","extravasation","."),4142036). assertion_content_comment('tOboGo_PositiveRegulationOfMononuclearCellMigration',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","mononuclear","cell","migration",".","Mononuclear","cell","migration","is","the","movement","of","a","mononuclear","cell","within","or","between","different","tissues","and","organs","of","the","body","."),4128939). assertion_content_comment('tOboGo_PositiveRegulationOfMononuclearCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mononuclear","cell","proliferation","."),4062015). assertion_content_comment('tOboGo_PositiveRegulationOfMonooxygenaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","monooxygenase","."),4014277). assertion_content_comment('tOboGo_PositiveRegulationOfMonophenolMonooxygenaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","the","enzyme","monophenol","oxygenase",".","Monophenol","monooxygenase","catalyzes","the","reaction",":","L-tyrosine","+","L-DOPA","+","O2","=","L-DOPA","+","DOPAquinone","+","H2O","."),4337527). assertion_content_comment('tOboGo_PositiveRegulationOfMonopolarCellGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","monopolar","cell","growth",",","polarized","growth","from","one","end","of","a","cell","."),4118735). assertion_content_comment('tOboGo_PositiveRegulationOfMRNACatabolicProcess',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","a","mRNA","catabolic","process",",","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","RNA",",","ribonucleic","acid",",","one","of","the","two","main","type","of","nucleic","acid",",","consisting","of","a","long",",","unbranched","macromolecule","formed","from","ribonucleotides","joined","in","3","'",",","5","'","-phosphodiester","linkage","."),4113255). assertion_content_comment('tOboGo_PositiveRegulationOfMRNACleavage',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mRNA","cleavage","."),4058261). assertion_content_comment('tOboGo_PositiveRegulationOfMRNAModification',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","covalent","alteration","of","one","or","more","nucleotides","within","an","mRNA","molecule","to","produce","an","mRNA","molecule","with","a","sequence","that","differs","from","that","coded","genetically","."),4150985). assertion_content_comment('tOboGo_PositiveRegulationOfMRNAProcessing',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mRNA","processing","."),4058213). assertion_content_comment('tOboGo_PositiveRegulationOfMucusSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","mucus","from","a","cell","or","group","of","cells","."),4137185). assertion_content_comment('tOboGo_PositiveRegulationOfMulticellularOrganismalMetabolicProcess',s("Any","process","that","activates","or","increases","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","in","multicellular","organisms","that","occur","at","the","tissue",",","organ",",","or","organismal","level","."),3991050). assertion_content_comment('tOboGo_PositiveRegulationOfMulticellularOrganismalProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","an","organismal","process",",","any","of","the","processes","pertinent","to","the","function","of","an","organism","above","the","cellular","level",";","includes","the","integrated","processes","of","tissues","and","organs","."),3984244). assertion_content_comment('tOboGo_PositiveRegulationOfMulticellularOrganismGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","growth","of","an","organism","to","reach","its","usual","body","size","."),4081709). assertion_content_comment('tOboGo_PositiveRegulationOfMuscleAdaptation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","muscle","adaptation","."),4028813). assertion_content_comment('tOboGo_PositiveRegulationOfMuscleAtrophy',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","muscle","atrophy","."),4040388). assertion_content_comment('tOboGo_PositiveRegulationOfMuscleCellApoptosis',s("Any","process","that","increases","the","rate","or","frequency","of","muscle","cell","apoptosis",".","Muscle","cell","apoptosis","is","a","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","muscle","cell","and","result","in","its","death","."),4026300). assertion_content_comment('tOboGo_PositiveRegulationOfMuscleCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","muscle","cell","differentiation","."),4036607). assertion_content_comment('tOboGo_PositiveRegulationOfMuscleContraction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","muscle","contraction","."),4040092). assertion_content_comment('tOboGo_PositiveRegulationOfMuscleHyperplasia',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","muscle","hyperplasia","."),4040399). assertion_content_comment('tOboGo_PositiveRegulationOfMuscleHypertrophy',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","muscle","hypertrophy","."),4028769). assertion_content_comment('tOboGo_PositiveRegulationOfMuscleOrganDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","muscle","development","."),4039773). assertion_content_comment('tOboGo_PositiveRegulationOfMyelination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","formation","of","a","myelin","sheath","around","nerve","axons","."),4059863). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","myeloid","cell","apoptosis","."),4065018). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","myeloid","cell","differentiation","."),3997723). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidDendriticCellActivation',s("Any","process","that","stimulates",",","induces","or","increases","the","rate","of","myeloid","dendritic","cell","activation","."),4061909). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","myeloid","dendritic","cell","antigen","processing","and","presentation","."),3994743). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidDendriticCellChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","myeloid","dendritic","cell","chemotaxis","."),4144799). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidDendriticCellCytokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","myeloid","dendritic","cell","cytokine","production","."),3998793). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidLeukocyteCytokineProductionInvolvedInImmuneResponse',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","production","of","a","cytokine","that","contributes","to","the","immune","response","."),3998789). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidLeukocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","myeloid","leukocyte","differentiation","."),3997731). assertion_content_comment('tOboGo_PositiveRegulationOfMyeloidLeukocyteMediatedImmunity',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","myeloid","leukocyte","mediated","immunity","."),3984323). assertion_content_comment('tOboGo_PositiveRegulationOfMyoblastDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","myoblast","differentiation",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4087398). assertion_content_comment('tOboGo_PositiveRegulationOfMyoblastProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","myoblast","proliferation","."),4140075). assertion_content_comment('tOboGo_PositiveRegulationOfMyosinLightChainKinaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","myosin","light","chain","kinase","activity","."),4379238). assertion_content_comment('tOboGo_PositiveRegulationOfMyotomeDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","myotome","development","."),4140065). assertion_content_comment('tOboGo_PositiveRegulationOfMyotubeDifferentiation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","myotube","differentiation",".","Myotube","differentiation","is","the","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","myotube","cell",".","Myotubes","are","multinucleated","cells","that","are","formed","when","proliferating","myoblasts","exit","the","cell","cycle",",","differentiate","and","fuse","."),4036624). assertion_content_comment('tOboGo_PositiveRegulationOfNADKinaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","NAD","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","an","NAD","molecule","."),4341272). assertion_content_comment('tOboGo_PositiveRegulationOfNADPHOxidaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","the","enzyme","NAD","(","P",")","H","oxidase","."),4343691). assertion_content_comment('tOboGo_PositiveRegulationOfNatriuresisByAngiotensin',s("OBSOLETE",".","The","process","in","which","angiotensin","increases","the","rate","of","natriuresis","indirectly","via","diuresis",".","Natriuresis","is","the","process","of","renal","sodium","excretion","."),4193617). assertion_content_comment('tOboGo_PositiveRegulationOfNatriuresisByPressureNatriuresis',s("OBSOLETE",".","The","process","in","which","pressure","natriuresis","increases","rate","of","natriuresis","."),4289239). assertion_content_comment('tOboGo_PositiveRegulationOfNatriuresis',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natriuresis","."),4193991). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","activation","."),4070558). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","death","by","apoptosis","."),4137121). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","chemotaxis","."),4145707). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellCytokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","cytokine","production","."),3998720). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellDegranulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","degranulation","."),4095684). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellDifferentiationInvolvedInImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","differentiation","as","part","of","an","immune","response","."),4070841). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","differentiation","."),4070784). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellMediatedCytotoxicityDirectedAgainstTumorCellTarget',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","cytotoxicity","directed","against","tumor","cell","target","."),4000218). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellMediatedCytotoxicity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","mediated","cytotoxicity","."),4000203). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellMediatedImmuneResponseToTumorCell',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","immune","response","to","a","tumor","cell","."),4000184). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellMediatedImmunity',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","immunity","."),3998707). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellProliferationInvolvedInImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","proliferation","as","part","of","an","immune","response","."),4070803). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","cell","proliferation","."),4070581). assertion_content_comment('tOboGo_PositiveRegulationOfNaturalKillerCellToleranceInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","tolerance","induction","."),4000677). assertion_content_comment('tOboGo_PositiveRegulationOfNecroptosis',s("Any","process","that","increases","the","rate","frequency","or","extent","of","necroptosis",".","Necroptosis","is","a","necrotic","cell","death","process","that","results","from","the","activation","of","endogenous","cellular","processes",",","such","as","signaling","involving","death","domain","receptors","and","Toll-like","receptors","."),4116489). assertion_content_comment('tOboGo_PositiveRegulationOfNecroticCellDeath',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","necrotic","cell","death",".","Necrotic","cell","death","is","a","cell","death","process","that","is","morphologically","characterized","by","a","gain","in","cell","volume","(","oncosis",")",",","swelling","of","organelles",",","plasma","membrane","rupture","and","subsequent","loss","of","intracellular","contents","."),4034901). assertion_content_comment('tOboGo_PositiveRegulationOfNegativeChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","in","a","concentration","gradient","of","a","specific","chemical","."),4100262). assertion_content_comment('tOboGo_PositiveRegulationOfNematodeLarvalDevelopment',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","nematode","larval","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","nematode","larva","over","time",",","from","its","formation","to","the","mature","structure",".","Nematode","larval","development","begins","with","the","newly","hatched","first-stage","larva","(","L1",")","and","ends","with","the","end","of","the","last","larval","stage","(","for","example","the","fourth","larval","stage","(","L4",")","in","C",".","elegans",")","Each","stage","of","nematode","larval","development","is","characterized","by","proliferation","of","specific","cell","lineages","and","an","increase","in","body","size","without","alteration","of","the","basic","body","plan",".","Nematode","larval","stages","are","separated","by","molts","in","which","each","stage-specific","exoskeleton",",","or","cuticle",",","is","shed","and","replaced","anew","."),4113565). assertion_content_comment('tOboGo_PositiveRegulationOfNerveGrowthFactorReceptorActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","activity","of","the","nerve","growth","factor","receptor","."),4286297). assertion_content_comment('tOboGo_PositiveRegulationOfNerveGrowthFactorReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","activity","of","the","nerve","growth","factor","receptor","signaling","pathway","."),4118244). assertion_content_comment('tOboGo_PositiveRegulationOfNervousSystemDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","nervous","system","development",",","the","origin","and","formation","of","nervous","tissue","."),4089891). assertion_content_comment('tOboGo_PositiveRegulationOfNeuralCrestFormation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","neural","crest","formation",".","Neural","crest","formation","is","the","formation","of","the","specialized","region","of","ectoderm","between","the","neural","ectoderm","(","neural","plate",")","and","non-neural","ectoderm",".","The","neural","crest","gives","rise","to","the","neural","crest","cells","that","migrate","away","from","this","region","as","neural","tube","formation","procedes","."),4152105). assertion_content_comment('tOboGo_PositiveRegulationOfNeuralPrecursorCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neural","precursor","cell","proliferation","."),3990375). assertion_content_comment('tOboGo_PositiveRegulationOfNeuralRetinaDevelopment',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","neural","retina","development",",","the","progression","of","the","neural","retina","over","time","from","its","initial","formation","to","the","mature","structure",".","The","neural","retina","is","the","part","of","the","retina","that","contains","neurons","and","photoreceptor","cells","."),4135244). assertion_content_comment('tOboGo_PositiveRegulationOfNeuroblastProliferation',s("Any","process","that","activates","or","increases","the","rate","of","neuroblast","proliferation","."),3990378). assertion_content_comment('tOboGo_PositiveRegulationOfNeurogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neurogenesis",",","the","origin","and","formation","of","neurons","."),3990350). assertion_content_comment('tOboGo_PositiveRegulationOfNeurologicalSystemProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","neurophysiological","process","."),4054330). assertion_content_comment('tOboGo_PositiveRegulationOfNeuronApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","death","of","neurons","by","apoptosis","."),4094434). assertion_content_comment('tOboGo_PositiveRegulationOfNeuronDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neuron","differentiation","."),4086990). assertion_content_comment('tOboGo_PositiveRegulationOfNeuronMaturation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neuron","maturation","."),4039590). assertion_content_comment('tOboGo_PositiveRegulationOfNeuronProjectionDevelopment',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","neuron","projection","development",".","Neuron","projection","development","is","the","process","whose","specific","outcome","is","the","progression","of","a","neuron","projection","over","time",",","from","its","formation","to","the","mature","structure",".","A","neuron","projection","is","any","process","extending","from","a","neural","cell",",","such","as","axons","or","dendrites","(","collectively","called","neurites",")"),4035798). assertion_content_comment('tOboGo_PositiveRegulationOfNeuronProjectionRegeneration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neuron","projection","regeneration",",","the","regrowth","of","neuronal","processes","such","as","axons","or","dendrites","following","their","loss","or","damage","."),4106767). assertion_content_comment('tOboGo_PositiveRegulationOfNeurotransmitterSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","neurotransmitter","."),3988236). assertion_content_comment('tOboGo_PositiveRegulationOfNeurotransmitterTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","neurotransmitter","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3988228). assertion_content_comment('tOboGo_PositiveRegulationOfNeurotransmitterUptake',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","neurotransmitter","into","a","neuron","or","glial","cell","."),4120429). assertion_content_comment('tOboGo_PositiveRegulationOfNeurotrophinProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","a","neurotrophin","."),4064549). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilAggregation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neutrophil","aggregation","."),4142096). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","neutrophil","apoptosis","."),4065061). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilChemotaxis',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","neutrophil","chemotaxis",".","Neutrophil","chemotaxis","is","the","directed","movement","of","a","neutrophil","cell",",","the","most","numerous","polymorphonuclear","leukocyte","found","in","the","blood",",","in","response","to","an","external","stimulus",",","usually","an","infection","or","wounding","."),4149816). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilDegranulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neutrophil","degranulation","."),4093612). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neutrophil","differentiation","."),4087357). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilExtravasation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","neutrophil","extravasation","."),4142607). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilMediatedCytotoxicity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","target","cell","by","a","neutrophil","."),4131661). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilMediatedKillingOfBacterium',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","bacterium","by","a","neutrophil","."),4131678). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilMediatedKillingOfFungus',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","fungal","cell","by","a","neutrophil","."),4131788). assertion_content_comment('tOboGo_PositiveRegulationOfNeutrophilMediatedKillingOfSymbiontCell',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","symbiont","target","cell","by","a","neutrophil","."),4131670). assertion_content_comment('tOboGo_PositiveRegulationOfNFATProteinImportIntoNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","movement","of","an","NFAT","protein","from","the","cytoplasm","to","the","nucleus","."),4118614). assertion_content_comment('tOboGo_PositiveRegulationOfNitricOxideBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","nitric","oxide","."),4089513). assertion_content_comment('tOboGo_PositiveRegulationOfNitricOxideMediatedSignalTransduction',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","nitric","oxide","mediated","signal","transduction",".","Nitric","oxide","mediated","signal","transduction","is","a","series","of","molecular","signals","mediated","by","the","detection","of","nitric","oxide","(","NO",")"),4024767). assertion_content_comment('tOboGo_PositiveRegulationOfNitrogenCompoundMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nitrogen","or","nitrogenous","compounds","."),3975339). assertion_content_comment('tOboGo_PositiveRegulationOfNitrogenUtilization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","nitrogen","utilization","."),4090194). assertion_content_comment('tOboGo_PositiveRegulationOfNKTCellActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","activation","."),4119404). assertion_content_comment('tOboGo_PositiveRegulationOfNKTCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","differentiation","."),4119886). assertion_content_comment('tOboGo_PositiveRegulationOfNKTCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","proliferation","."),4119821). assertion_content_comment('tOboGo_PositiveRegulationOfNorepinephrineSecretion',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","norepinephrine","."),4026701). assertion_content_comment('tOboGo_PositiveRegulationOfNorepinephrineUptake',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","norepinephrine","into","a","cell","."),4121507). assertion_content_comment('tOboGo_PositiveRegulationOfNotchSignalingPathwayInvolvedInHeartInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","that","contributes","to","heart","induction","."),4084433). assertion_content_comment('tOboGo_PositiveRegulationOfNotchSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","Notch","signaling","pathway","."),4084422). assertion_content_comment('tOboGo_PositiveRegulationOfNuclearDivision',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","nuclear","division",",","the","partitioning","of","the","nucleus","and","its","genetic","information","."),4012229). assertion_content_comment('tOboGo_PositiveRegulationOfNuclearMRNASplicingViaSpliceosome',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","mRNA","splicing","via","a","spliceosomal","mechanism","."),4104507). assertion_content_comment('tOboGo_PositiveRegulationOfNucleaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","nuclease","activity",",","the","hydrolysis","of","ester","linkages","within","nucleic","acids","."),4013557). assertion_content_comment('tOboGo_PositiveRegulationOfNucleobaseNucleosideNucleotideAndNucleicAcidMetabolicProcess',s("Any","cellular","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids","."),3975349). assertion_content_comment('tOboGo_PositiveRegulationOfNucleobaseNucleosideNucleotideAndNucleicAcidTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053762). assertion_content_comment('tOboGo_PositiveRegulationOfNucleocytoplasmicTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","between","the","nucleus","and","the","cytoplasm","."),4020155). assertion_content_comment('tOboGo_PositiveRegulationOfNucleosideMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleosides","."),4092267). assertion_content_comment('tOboGo_PositiveRegulationOfNucleosideTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","nucleoside","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053793). assertion_content_comment('tOboGo_PositiveRegulationOfNucleotideBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","nucleotides","."),4050271). assertion_content_comment('tOboGo_PositiveRegulationOfNucleotideCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nucleotides","."),4050371). assertion_content_comment('tOboGo_PositiveRegulationOfNucleotideMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleotides","."),4050241). assertion_content_comment('tOboGo_PositiveRegulationOfNurseCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","nurse","cell","apoptosis","."),4090260). assertion_content_comment('tOboGo_PositiveRegulationOfOctopamineOrTyramineSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","octopamine","or","tyramine","signaling","pathway","."),4137719). assertion_content_comment('tOboGo_PositiveRegulationOfOctopamineSignalingPathwayInvolvedInResponseToFood',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","octopamine","signaling","pathway","involved","in","response","to","food","."),4137730). assertion_content_comment('tOboGo_PositiveRegulationOfOctopamineSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","octopamine","signaling","pathway","."),4137725). assertion_content_comment('tOboGo_PositiveRegulationOfOdontogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","formation","and","development","of","a","tooth","or","teeth","."),4078573). assertion_content_comment('tOboGo_PositiveRegulationOfOligodendrocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","oligodendrocyte","differentiation","."),4107206). assertion_content_comment('tOboGo_PositiveRegulationOfOligodendrocyteProgenitorProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","oligodendrocyte","progenitor","proliferation","."),4136343). assertion_content_comment('tOboGo_PositiveRegulationOfOocyteDevelopment',s("Any","process","that","increases","the","rate","or","extent","of","the","process","whose","specific","outcome","is","the","progression","of","an","oocyte","over","time",",","from","initial","commitment","of","the","cell","to","its","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4115844). assertion_content_comment('tOboGo_PositiveRegulationOfOogoniumDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","oogonium","development",",","a","process","that","leads","to","the","formation","of","a","female","gametangium","of","oomycetes",",","containing","one","or","more","gametes","."),4148487). assertion_content_comment('tOboGo_PositiveRegulationOfOomyceteSporangiumDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","oomycete","sporangium","development",",","a","process","that","leads","to","the","formation","of","oomycete","sporangium",",","a","single-celled","or","many-celled","structure","that","germinates","directly","to","form","an","infection","hypha","or","differentiate",",","through","specialized","cleavage","vesicles",",","into","between","10","and","30","zoospores",",","which","is","laterally","flagellated","."),4147986). assertion_content_comment('tOboGo_PositiveRegulationOfOosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","oospore","formation",",","a","process","in","which","male","and","female","gametangia","develop","and","fuse","to","form","a","thick-walled","resting","spore","of","oomycetes","."),4148656). assertion_content_comment('tOboGo_PositiveRegulationOfOpioidReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","opioid","receptor","signaling","pathway","."),4145498). assertion_content_comment('tOboGo_PositiveRegulationOfOpticNerveFormation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","optic","nerve","formation","."),4143866). assertion_content_comment('tOboGo_PositiveRegulationOfOrganelleOrganization',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","organelle","."),3975810). assertion_content_comment('tOboGo_PositiveRegulationOfOrganGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","growth","of","an","organ","of","an","organism","."),4087988). assertion_content_comment('tOboGo_PositiveRegulationOfOrganicAcidTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","organic","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990831). assertion_content_comment('tOboGo_PositiveRegulationOfOskarMRNATranslation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","oskar","mRNA","translation","."),4348201). assertion_content_comment('tOboGo_PositiveRegulationOfOsteoclastDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","osteoclast","differentiation","."),4087449). assertion_content_comment('tOboGo_PositiveRegulationOfOvarianFollicleDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ovarian","follicle","development","."),4142553). assertion_content_comment('tOboGo_PositiveRegulationOfOvulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ovulation",",","the","release","of","a","mature","ovum/oocyte","from","an","ovary","."),4115856). assertion_content_comment('tOboGo_PositiveRegulationOfOxidativePhosphorylationUncouplerActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","oxidative","phosphorylation","uncoupler","activity","."),4169314). assertion_content_comment('tOboGo_PositiveRegulationOfOxidoreductaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","oxidoreductase","activity",",","the","catalysis","of","an","oxidation-reduction","(","redox",")","reaction",",","a","reversible","chemical","reaction","in","which","the","oxidation","state","of","an","atom","or","atoms","within","a","molecule","is","altered","."),4014268). assertion_content_comment('tOboGo_PositiveRegulationOfOxygenAndReactiveOxygenSpeciesMetabolicProcess',s("OBSOLETE",".","Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","dioxygen","(","O2",")",",","or","any","of","the","reactive","oxygen","species",",","e.g",".","superoxide","anions","(","O2-",")",",","hydrogen","peroxide","(","H2O2",")",",","and","hydroxyl","radicals","(","-OH",")"),4336360). assertion_content_comment('tOboGo_PositiveRegulationOfOxygenMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","oxygen","metabolic","process","."),4143026). assertion_content_comment('tOboGo_PositiveRegulationOfPancreaticACellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","pancreatic","A","cell","differentiation","."),4140965). assertion_content_comment('tOboGo_PositiveRegulationOfPancreaticJuiceSecretion',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","pancreatic","juice","secretion",",","the","regulated","release","of","pancreatic","juice","by","the","exocrine","pancreas","into","the","upper","part","of","the","intestine","."),4149480). assertion_content_comment('tOboGo_PositiveRegulationOfPancreaticStellateCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","pancreatic","stellate","cell","proliferation","."),4140605). assertion_content_comment('tOboGo_PositiveRegulationOfParaxialMesodermalCellFateDetermination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","paraxial","mesoderm","cell","fate","determination","."),4102741). assertion_content_comment('tOboGo_PositiveRegulationOfParaxialMesodermalCellFateSpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","paraxial","mesoderm","cell","fate","specification","."),4102705). assertion_content_comment('tOboGo_PositiveRegulationOfPenicillinCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","leading","to","the","breakdown","of","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4066872). assertion_content_comment('tOboGo_PositiveRegulationOfPenicillinMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4066844). assertion_content_comment('tOboGo_PositiveRegulationOfPenileErection',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","penile","erection",".","Penile","erection","is","the","hardening",",","enlarging","and","rising","of","the","penis","which","often","occurs","in","the","sexually","aroused","male","and","enables","sexual","intercourse",".","Achieved","by","increased","inflow","of","blood","into","the","vessels","of","erectile","tissue",",","and","decreased","outflow","."),4117444). assertion_content_comment('tOboGo_PositiveRegulationOfPeptidaseActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","peptidase","activity",",","the","hydrolysis","of","peptide","bonds","within","proteins","."),4011539). assertion_content_comment('tOboGo_PositiveRegulationOfPeptideHormoneProcessing',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","peptide","hormone","processing",".","Peptide","hormone","processing","is","the","generation","of","a","mature","peptide","hormone","by","posttranslational","processing","of","a","prohormone","."),4117164). assertion_content_comment('tOboGo_PositiveRegulationOfPeptideHormoneSecretion',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","regulated","release","of","a","peptide","hormone","from","secretory","granules","."),4057086). assertion_content_comment('tOboGo_PositiveRegulationOfPeptideSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","peptide","secretion","."),3997328). assertion_content_comment('tOboGo_PositiveRegulationOfPeptidoglycanRecognitionProteinSignalingPathway',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","peptidoglycan","recognition","protein","signaling","pathway","."),4113653). assertion_content_comment('tOboGo_PositiveRegulationOfPeripheralBCellAnergy',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","peripheral","B","cell","anergy","."),3999709). assertion_content_comment('tOboGo_PositiveRegulationOfPeripheralBCellDeletion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","peripheral","B","cell","deletion","."),3999853). assertion_content_comment('tOboGo_PositiveRegulationOfPeripheralTCellToleranceInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","peripheral","T","cell","tolerance","induction","."),4000351). assertion_content_comment('tOboGo_PositiveRegulationOfPeripheralToleranceInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","peripheral","tolerance","induction","."),3995269). assertion_content_comment('tOboGo_PositiveRegulationOfPeroxidaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","peroxidase","activity","."),4171837). assertion_content_comment('tOboGo_PositiveRegulationOfPeroxisomeProliferatorActivatedReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","peroxisome","proliferator","activated","receptor","signaling","pathway","."),4083394). assertion_content_comment('tOboGo_PositiveRegulationOfPhagocytosisEngulfment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","internalization","of","bacteria",",","immune","complexes","and","other","particulate","matter","or","of","an","apoptotic","cell","by","phagocytosis","."),4108762). assertion_content_comment('tOboGo_PositiveRegulationOfPhagocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","phagocytosis","."),4101039). assertion_content_comment('tOboGo_PositiveRegulationOfPhialideDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","phialide","development",",","a","process","that","leads","to","the","formation","of","phialides",".","Phialides","are","specialized","cells","that","bud","from","the","ends","of","metulae","on","the","conidiophore","tip","."),4132423). assertion_content_comment('tOboGo_PositiveRegulationOfPhosphataseActivity',s("Any","process","that","increases","the","rate","or","frequency","of","phosphatase","activity",".","Phosphatases","catalyze","the","hydrolysis","of","phosphoric","monoesters",",","releasing","inorganic","phosphate","."),4160739). assertion_content_comment('tOboGo_PositiveRegulationOfPhosphateMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","phosphates","."),3988640). assertion_content_comment('tOboGo_PositiveRegulationOfPhosphateTransmembraneTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","phosphate","transmembrane","transport","."),4141389). assertion_content_comment('tOboGo_PositiveRegulationOfPhosphatidylinositolBiosyntheticProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidylinositol","."),4030382). assertion_content_comment('tOboGo_PositiveRegulationOfPhospholipaseA2Activity',s("Any","process","that","activates","or","increases","the","activity","of","the","enzyme","phospholipase","A2","."),4318017). assertion_content_comment('tOboGo_PositiveRegulationOfPhospholipaseActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","phospholipase","activity",",","the","hydrolysis","of","a","phospholipid","."),4049040). assertion_content_comment('tOboGo_PositiveRegulationOfPhospholipaseCActivity',s("Any","process","that","increases","the","rate","of","phospholipase","C","activity","."),4049042). assertion_content_comment('tOboGo_PositiveRegulationOfPhospholipidBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phospholipids","."),4030370). assertion_content_comment('tOboGo_PositiveRegulationOfPhospholipidCatabolicProcess',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","phospholipid","catabolism",",","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phospholipids",",","any","lipid","containing","phosphoric","acid","as","a","mono-","or","diester","."),4112379). assertion_content_comment('tOboGo_PositiveRegulationOfPhospholipidTranslocation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","translocation",",","or","flipping",",","of","phospholipid","molecules","from","one","monolayer","of","a","membrane","bilayer","to","the","opposite","monolayer","."),4135453). assertion_content_comment('tOboGo_PositiveRegulationOfPhosphoproteinPhosphataseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","phosphoprotein","phosphatase","."),4331538). assertion_content_comment('tOboGo_PositiveRegulationOfPhosphorusMetabolicProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","phosphorus","or","compounds","containing","phosphorus","."),3988636). assertion_content_comment('tOboGo_PositiveRegulationOfPhosphorusUtilization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","phosphorus","utilization","."),4092704). assertion_content_comment('tOboGo_PositiveRegulationOfPhosphorylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","addition","of","phosphate","groups","to","a","molecule","."),3988649). assertion_content_comment('tOboGo_PositiveRegulationOfPhotomorphogenesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","photomorphogenesis","."),4139844). assertion_content_comment('tOboGo_PositiveRegulationOfPhotoreceptorCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","photoreceptor","cell","differentiation",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4087524). assertion_content_comment('tOboGo_PositiveRegulationOfPhytoalexinBiosyntheticProcess',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","phytoalexin","biosynthesis",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytoalexins","."),4110359). assertion_content_comment('tOboGo_PositiveRegulationOfPhytoalexinMetabolicProcess',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","phytoalexin","metabolism",",","the","chemical","reactions","and","pathways","involving","phytoalexins","."),4110350). assertion_content_comment('tOboGo_PositiveRegulationOfPigmentCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","pigment","cell","differentiation","."),4086957). assertion_content_comment('tOboGo_PositiveRegulationOfPinocytosis',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","pinocytosis",".","Pinocytosis","is","the","process","in","which","cells","take","in","liquid","material","from","their","external","environment",";","literally","'","cell","drinking","'","Liquid","is","enclosed","in","vesicles",",","formed","by","invagination","of","the","plasma","membrane",".","These","vesicles","then","move","into","the","cell","and","pass","their","contents","to","endosomes","."),4103051). assertion_content_comment('tOboGo_PositiveRegulationOfPlasmacytoidDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","plasmacytoid","dendritic","cell","antigen","processing","and","presentation","."),3994678). assertion_content_comment('tOboGo_PositiveRegulationOfPlasmacytoidDendriticCellCytokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","plasmacytoid","dendritic","cell","cytokine","production","."),3997208). assertion_content_comment('tOboGo_PositiveRegulationOfPlasmatocyteDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","plasmatocyte","differentiation","."),4087209). assertion_content_comment('tOboGo_PositiveRegulationOfPlasminogenActivation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","plasminogen","activation",".","Plasminogen","activation","is","the","process","in","which","plasminogen","is","processed","to","plasmin","."),4024910). assertion_content_comment('tOboGo_PositiveRegulationOfPlateletActivation',s("Any","process","that","increases","the","rate","or","frequency","of","platelet","activation",".","Platelet","activation","is","a","series","of","progressive",",","overlapping","events","triggered","by","exposure","of","the","platelets","to","subendothelial","tissue","."),4027783). assertion_content_comment('tOboGo_PositiveRegulationOfPodosomeAssembly',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","podosome","assembly","."),4129435). assertion_content_comment('tOboGo_PositiveRegulationOfPolarizedEpithelialCellDifferentiation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","polarized","epithelial","cell","differentiation","."),4061787). assertion_content_comment('tOboGo_PositiveRegulationOfPolePlasmOskarMRNALocalization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","process","in","which","oskar","mRNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm","."),4090277). assertion_content_comment('tOboGo_PositiveRegulationOfPositiveChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","in","a","concentration","gradient","of","a","specific","chemical","."),4100015). assertion_content_comment('tOboGo_PositiveRegulationOfPositiveChemotaxisToCAMPByChlorinatedAlkylphenone',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","by","the","action","of","a","chlorinated","alkylphenone",".","An","alkylphenone","is","an","aromatic","polyketide","with","methyl","and","chlorine","substitutions","."),4156124). assertion_content_comment('tOboGo_PositiveRegulationOfPositiveChemotaxisToCAMP',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","."),4135487). assertion_content_comment('tOboGo_PositiveRegulationOfPosteriorGapGeneTranscription',s("The","activation","of","genes","encoding","transcription","factors","in","the","posterior","region","of","an","insect","embryo","by","a","combination","of","maternal","regulatory","signals","and","interactions","among","themselves",";","exemplified","by","the","activation","of","expression","of","the","Drosophila","knirps","gene","."),4019432). assertion_content_comment('tOboGo_PositiveRegulationOfPosteriorNeuralPlateFormationByFibroblastGrowthFactorReceptorSignalingPathway',s("Any","process","that","increases","the","rate","or","extent","of","the","formation","of","the","posterior","neural","plate",",","the","posterior","end","of","the","flat",",","thickened","layer","of","ectodermal","cells","known","as","the","neural","plate","."),4110830). assertion_content_comment('tOboGo_PositiveRegulationOfPosteriorNeuralPlateFormationByWntReceptorSignalingPathway',s("The","series","of","molecular","signals","initiated","by","binding","of","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell","and","increasing","the","rate","or","extent","of","posterior","neural","plate","formation","."),4149829). assertion_content_comment('tOboGo_PositiveRegulationOfPosttranscriptionalGeneSilencing',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","inactivation","of","gene","expression","by","a","posttranscriptional","mechanism","."),4108278). assertion_content_comment('tOboGo_PositiveRegulationOfPotassiumIonTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","potassium","ions","(","K","+",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4093264). assertion_content_comment('tOboGo_PositiveRegulationOfPreblastodermMitoticCellCycle',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","progression","through","the","preblastoderm","mitotic","cell","cycle","."),4092021). assertion_content_comment('tOboGo_PositiveRegulationOfPrimaryMicroRNAProcessing',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","primary","microRNA","processing","."),4143893). assertion_content_comment('tOboGo_PositiveRegulationOfProductionOfMolecularMediatorOfImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","the","production","of","molecular","mediator","of","immune","response","."),3993317). assertion_content_comment('tOboGo_PositiveRegulationOfProgesteroneBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","progesterone","biosynthetic","process","."),4141327). assertion_content_comment('tOboGo_PositiveRegulationOfProgrammedCellDeath',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death",",","cell","death","resulting","from","activation","of","endogenous","cellular","processes","."),3983070). assertion_content_comment('tOboGo_PositiveRegulationOfProlineMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","proline","metabolic","process","."),4140772). assertion_content_comment('tOboGo_PositiveRegulationOfProstaglandinBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","prostaglandin","."),4058589). assertion_content_comment('tOboGo_PositiveRegulationOfProstaglandinSecretionInvolvedInImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","prostaglandin","from","a","cell","or","group","of","cells","and","contributes","to","the","immune","response","."),4135277). assertion_content_comment('tOboGo_PositiveRegulationOfProstaglandinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","prostaglandin","from","a","cell","or","group","of","cells","."),4056336). assertion_content_comment('tOboGo_PositiveRegulationOfProstheticGroupMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","prosthetic","group","."),4119642). assertion_content_comment('tOboGo_PositiveRegulationOfProteinActivationCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","activation","cascade","."),3986474). assertion_content_comment('tOboGo_PositiveRegulationOfProteinAutophosphorylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","phosphorylation","by","a","protein","of","one","or","more","of","its","own","residues","."),4057777). assertion_content_comment('tOboGo_PositiveRegulationOfProteinBinding',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","binding","."),4155002). assertion_content_comment('tOboGo_PositiveRegulationOfProteinCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","by","the","destruction","of","the","native",",","active","configuration",",","with","or","without","the","hydrolysis","of","peptide","bonds","."),3995793). assertion_content_comment('tOboGo_PositiveRegulationOfProteinComplexAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","complex","assembly","."),3988843). assertion_content_comment('tOboGo_PositiveRegulationOfProteinComplexDisassembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","complex","disassembly",",","the","disaggregation","of","a","protein","complex","into","its","constituent","components","."),4051258). assertion_content_comment('tOboGo_PositiveRegulationOfProteinDeacetylation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","protein","deacetylation",",","the","removal","of","an","acetyl","group","from","a","protein","amino","acid",".","An","acetyl","group","is","CH3CO-",",","derived","from","acetic","[","ethanoic","]","acid","."),4062788). assertion_content_comment('tOboGo_PositiveRegulationOfProteinDephosphorylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","removal","of","phosphate","groups","from","a","protein","."),4071440). assertion_content_comment('tOboGo_PositiveRegulationOfProteinDesumoylation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","protein","desumoylation",".","Protein","desumoylation","is","the","process","in","which","a","SUMO","protein","(","small","ubiquitin-related","modifier",")","is","cleaved","from","its","target","protein","."),4115542). assertion_content_comment('tOboGo_PositiveRegulationOfProteinExitFromEndoplasmicReticulum',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","directed","movement","of","proteins","from","the","endoplasmic","reticulum","."),4132232). assertion_content_comment('tOboGo_PositiveRegulationOfProteinExportFromNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","directed","movement","of","proteins","from","the","nucleus","into","the","cytoplasm","."),4099633). assertion_content_comment('tOboGo_PositiveRegulationOfProteinGeranylgeranylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","geranylgeranylation","."),4145375). assertion_content_comment('tOboGo_PositiveRegulationOfProteinGlutathionylation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","protein","glutathionylation",".","Protein","glutathionylation","is","the","protein","modification","process","in","which","a","glutathione","molecule","is","added","to","a","protein","amino","acid","through","a","disulfide","linkage","."),4024507). assertion_content_comment('tOboGo_PositiveRegulationOfProteinGlycosylationInGolgi',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","addition","of","a","sugar","unit","to","a","protein","amino","acid","in","any","compartment","of","the","Golgi","apparatus","."),4152150). assertion_content_comment('tOboGo_PositiveRegulationOfProteinGlycosylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","glycosylation","of","one","or","more","amino","acid","residues","within","a","protein",".","Protein","glycosylation","is","the","addition","of","a","sugar","unit","to","a","protein","amino","acid",",","e.g",".","the","addition","of","glycan","chains","to","proteins","."),4109166). assertion_content_comment('tOboGo_PositiveRegulationOfProteinHistidineKinaseActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","protein","histidine","kinase","activity","."),4328990). assertion_content_comment('tOboGo_PositiveRegulationOfProteinHomodimerizationActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","protein","homodimerization",",","interacting","selectively","with","an","identical","protein","to","form","a","homodimer","."),4155010). assertion_content_comment('tOboGo_PositiveRegulationOfProteinHomooligomerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","homooligomerization","."),4055933). assertion_content_comment('tOboGo_PositiveRegulationOfProteinImportIntoNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","movement","of","proteins","from","the","cytoplasm","into","the","nucleus","."),4020176). assertion_content_comment('tOboGo_PositiveRegulationOfProteinImportIntoNucleusTranslocation',s("Any","process","that","activates","or","increases","the","vectorial","transfer","of","a","protein","from","the","cytoplasm","into","the","nucleus",",","across","the","nuclear","membrane","."),4065676). assertion_content_comment('tOboGo_PositiveRegulationOfProteinKinaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","kinase","activity","."),3972593). assertion_content_comment('tOboGo_PositiveRegulationOfProteinKinaseASignalingCascade',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","protein","kinase","A","signaling","cascade",".","The","PKA","signaling","cascade","is","the","series","of","reactions",",","mediated","by","the","intracellular","serine/threonine","kinase","protein","kinase","A",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4024553). assertion_content_comment('tOboGo_PositiveRegulationOfProteinKinaseBSignalingCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","protein","kinase","B","signaling","cascade",",","a","series","of","reactions","mediated","by","the","intracellular","serine/threonine","kinase","protein","kinase","B","."),4120135). assertion_content_comment('tOboGo_PositiveRegulationOfProteinKinaseCSignalingCascade',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","a","series","of","reactions",",","mediated","by","the","intracellular","serine/threonine","kinase","protein","kinase","C",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4149968). assertion_content_comment('tOboGo_PositiveRegulationOfProteinLocalizationAtCellSurface',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","localization","at","cell","surface","."),4139377). assertion_content_comment('tOboGo_PositiveRegulationOfProteinMaturationByPeptideBondCleavage',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","protein","maturation","by","peptide","bond","cleavage","."),3986460). assertion_content_comment('tOboGo_PositiveRegulationOfProteinMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","protein","."),3975842). assertion_content_comment('tOboGo_PositiveRegulationOfProteinModificationProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","covalent","alteration","of","one","or","more","amino","acid","residues","within","a","protein","."),3975860). assertion_content_comment('tOboGo_PositiveRegulationOfProteinNeddylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","neddylation","."),4141993). assertion_content_comment('tOboGo_PositiveRegulationOfProteinOligomerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","oligomerization","."),4055448). assertion_content_comment('tOboGo_PositiveRegulationOfProteinPhosphataseType2AActivity',s("Any","process","that","activates","or","increases","the","activity","of","the","enzyme","protein","phosphatase","type","2A","."),4360871). assertion_content_comment('tOboGo_PositiveRegulationOfProteinPhosphataseType2BActivity',s("Any","process","that","activates","or","increases","the","activity","of","the","enzyme","protein","phosphatase","type","2B","."),4331574). assertion_content_comment('tOboGo_PositiveRegulationOfProteinPhosphorylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","addition","of","phosphate","groups","to","amino","acids","within","a","protein","."),3988657). assertion_content_comment('tOboGo_PositiveRegulationOfProteinPolymerization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","process","of","creating","protein","polymers","."),4051428). assertion_content_comment('tOboGo_PositiveRegulationOfProteinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","controlled","release","of","a","protein","from","a","cell","or","group","of","cells","."),3997025). assertion_content_comment('tOboGo_PositiveRegulationOfProteinSerineThreonineKinaseActivity',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","protein","serine/threonine","kinase","activity","."),3972600). assertion_content_comment('tOboGo_PositiveRegulationOfProteinSumoylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","addition","of","SUMO","groups","to","a","protein","."),4066546). assertion_content_comment('tOboGo_PositiveRegulationOfProteinTargetingToMembrane',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","process","of","directing","proteins","towards","a","membrane",",","usually","using","signals","contained","within","the","protein","."),4150760). assertion_content_comment('tOboGo_PositiveRegulationOfProteinTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","protein","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3997017). assertion_content_comment('tOboGo_PositiveRegulationOfProteinTyrosineKinaseActivity',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","protein","tyrosine","kinase","activity","."),4155924). assertion_content_comment('tOboGo_PositiveRegulationOfProteinUbiquitination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","addition","of","ubiquitin","groups","to","a","protein","."),4012375). assertion_content_comment('tOboGo_PositiveRegulationOfProteolysisAssociatedWithAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","proteolysis","associated","with","antigen","processing","and","presentation","."),3995805). assertion_content_comment('tOboGo_PositiveRegulationOfProteolysis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","."),3986451). assertion_content_comment('tOboGo_PositiveRegulationOfPseudohyphalGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","pseudohyphal","growth","."),4140857). assertion_content_comment('tOboGo_PositiveRegulationOfPseudopodiumAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","assembly","of","pseudopodia","."),4059498). assertion_content_comment('tOboGo_PositiveRegulationOfPteridineMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","pteridine","."),4090315). assertion_content_comment('tOboGo_PositiveRegulationOfPurineBaseMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","purine","bases","."),4092303). assertion_content_comment('tOboGo_PositiveRegulationOfPurineNucleosideTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","purine","nucleoside","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053889). assertion_content_comment('tOboGo_PositiveRegulationOfPurineNucleotideCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","nucleotides","."),4050404). assertion_content_comment('tOboGo_PositiveRegulationOfPyrimidineBaseMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","pyrimidine","bases","."),4092166). assertion_content_comment('tOboGo_PositiveRegulationOfR7CellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","R7","cell","differentiation","."),4087538). assertion_content_comment('tOboGo_PositiveRegulationOfR8CellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","R8","cell","differentiation","."),4091631). assertion_content_comment('tOboGo_PositiveRegulationOfR8CellSpacingInCompoundEye',s("Any","process","that","activates","or","enforces","the","correct","R8","cell","spacing","in","a","compound","eye","."),4297779). assertion_content_comment('tOboGo_PositiveRegulationOfRabGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","GTPase","of","the","Rab","family","."),4337252). assertion_content_comment('tOboGo_PositiveRegulationOfRacGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","GTPase","of","the","Rac","family","."),4337366). assertion_content_comment('tOboGo_PositiveRegulationOfRacProteinSignalTransduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Rac","protein","signal","transduction","."),4072558). assertion_content_comment('tOboGo_PositiveRegulationOfRalGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","GTPase","of","the","Ral","family","."),4337238). assertion_content_comment('tOboGo_PositiveRegulationOfRanGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","GTPase","of","the","Ran","family","."),4337418). assertion_content_comment('tOboGo_PositiveRegulationOfRanProteinSignalTransduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Ran","protein","signal","transduction","."),4057000). assertion_content_comment('tOboGo_PositiveRegulationOfRapGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","GTPase","of","the","Rap","family","."),4337392). assertion_content_comment('tOboGo_PositiveRegulationOfRasGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","GTPase","of","the","Ras","superfamily","."),4317903). assertion_content_comment('tOboGo_PositiveRegulationOfRasProteinSignalTransduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Ras","protein","signal","transduction","."),4056992). assertion_content_comment('tOboGo_PositiveRegulationOfReactiveOxygenSpeciesMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","reactive","oxygen","species","metabolic","process","."),4024287). assertion_content_comment('tOboGo_PositiveRegulationOfReceptorActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","receptor","activity","."),4161177). assertion_content_comment('tOboGo_PositiveRegulationOfReceptorBiosyntheticProcess',s("Any","process","that","increases","the","frequency","or","rate","of","receptor","biosynthesis",".","Receptor","biosynthesis","is","the","collection","of","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","receptor","molecule",",","a","macromolecule","that","undergoes","combination","with","a","hormone",",","neurotransmitter",",","drug","or","intracellular","messenger","to","initiate","a","change","in","cell","function","."),4037221). assertion_content_comment('tOboGo_PositiveRegulationOfReceptorCatabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","receptor","catabolic","process","."),4070457). assertion_content_comment('tOboGo_PositiveRegulationOfReceptorInternalization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","receptor","internalization","."),3992679). assertion_content_comment('tOboGo_PositiveRegulationOfReceptorRecycling',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","receptor","recycling","."),3989450). assertion_content_comment('tOboGo_PositiveRegulationOfReciprocalMeioticRecombination',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","recombination","during","meiosis",".","Reciprocal","meiotic","recombination","is","the","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","."),4036886). assertion_content_comment('tOboGo_PositiveRegulationOfRecombinationWithinRDNARepeats',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","genetic","recombination","within","the","DNA","of","the","genes","coding","for","ribosomal","RNA","."),4298352). assertion_content_comment('tOboGo_PositiveRegulationOfRegulationOfInsulinSecretionInvolvedInCellularResponseToGlucoseStimulus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","regulation","of","insulin","secretion","involved","in","cellular","response","to","glucose","stimulus","."),4172227). assertion_content_comment('tOboGo_PositiveRegulationOfRegulationOfSecondaryHeartFieldCardioblastProliferation',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","regulation","of","secondary","heart","field","cardioblast","proliferation","."),4170339). assertion_content_comment('tOboGo_PositiveRegulationOfRegulatoryTCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","differentiation","of","regulatory","T","cells","."),4069886). assertion_content_comment('tOboGo_PositiveRegulationOfReleaseOfCytochromeCFromMitochondria',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","release","of","cytochrome","c","from","mitochondria",",","the","process","in","which","cytochrome","c","is","enabled","to","move","from","the","mitochondrial","intermembrane","space","into","the","cytosol",",","which","is","an","early","step","in","apoptosis","and","leads","to","caspase","activation","."),4149522). assertion_content_comment('tOboGo_PositiveRegulationOfReleaseOfSequesteredCalciumIonIntoCytosol',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","release","into","the","cytosolic","compartment","of","calcium","ions","sequestered","in","the","endoplasmic","reticulum","or","mitochondria","."),4119934). assertion_content_comment('tOboGo_PositiveRegulationOfRenalAlbuminAbsorption',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","renal","albumin","absorption","."),4145162). assertion_content_comment('tOboGo_PositiveRegulationOfRenalOutputByAngiotensin',s("OBSOLETE",".","Any","process","in","which","angiotensin","directly","increases","the","rate","of","natriuresis","and","diuresis","in","the","kidney","."),4193924). assertion_content_comment('tOboGo_PositiveRegulationOfRenalSodiumExcretionByPressureNatriuresis',s("An","increase","in","the","amount","of","sodium","excreted","in","urine","over","a","unit","of","time",",","as","a","result","of","pressure","natriuresis","."),4289235). assertion_content_comment('tOboGo_PositiveRegulationOfRenalSodiumExcretion',s("Any","process","that","increases","the","amount","of","sodium","excreted","in","urine","over","a","unit","of","time","."),4081148). assertion_content_comment('tOboGo_PositiveRegulationOfReproductiveProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","reproductive","process","."),4021321). assertion_content_comment('tOboGo_PositiveRegulationOfRespiratoryBurstInvolvedInInflammatoryResponse',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","a","phase","of","elevated","metabolic","activity",",","during","which","oxygen","consumption","increases","made","as","a","defense","response",";","this","leads","to","the","production",",","by","an","NADH","dependent","system",",","of","hydrogen","peroxide","(","H2O2",")",",","superoxide","anions","and","hydroxyl","radicals","."),4115962). assertion_content_comment('tOboGo_PositiveRegulationOfRespiratoryBurst',s("Any","process","that","increases","the","rate","frequency","or","extent","of","a","phase","of","elevated","metabolic","activity",",","during","which","oxygen","consumption","increases",";","this","leads","to","the","production",",","by","an","NADH","dependent","system",",","of","hydrogen","peroxide","(","H2O2",")",",","superoxide","anions","and","hydroxyl","radicals","."),4115959). assertion_content_comment('tOboGo_PositiveRegulationOfResponseToBioticStimulus',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","response","to","biotic","stimulus","."),3996758). assertion_content_comment('tOboGo_PositiveRegulationOfResponseToCytokineStimulus',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","a","response","to","cytokine","stimulus","."),3987811). assertion_content_comment('tOboGo_PositiveRegulationOfResponseToExternalStimulus',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","a","response","to","an","external","stimulus","."),3983479). assertion_content_comment('tOboGo_PositiveRegulationOfResponseToExtracellularStimulus',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","a","response","to","an","extracellular","stimulus","."),4030465). assertion_content_comment('tOboGo_PositiveRegulationOfResponseToFood',s("Any","process","that","activates",",","maintains",",","or","increases","the","rate","of","a","response","to","a","food","stimulus","."),4057151). assertion_content_comment('tOboGo_PositiveRegulationOfResponseToNutrientLevels',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","response","to","nutrient","levels","."),4030474). assertion_content_comment('tOboGo_PositiveRegulationOfResponseToStimulus',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","a","response","to","a","stimulus",".","Response","to","stimulus","is","a","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","stimulus","."),3983454). assertion_content_comment('tOboGo_PositiveRegulationOfResponseToTumorCell',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","response","to","tumor","cell","."),4000163). assertion_content_comment('tOboGo_PositiveRegulationOfRetinalCellProgrammedCellDeath',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","programmed","cell","death","that","occurs","in","the","retina","."),4099126). assertion_content_comment('tOboGo_PositiveRegulationOfRetinalRodCellFateCommitment',s("Any","process","that","increases","the","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","retinal","rod","cell",".","A","retinal","rod","cell","is","one","of","the","two","photoreceptor","subtypes","in","a","camera-type","eye","."),4115433). assertion_content_comment('tOboGo_PositiveRegulationOfRetinoicAcidReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","retinoic","acid","receptor","signaling","pathway","activity","."),4102202). assertion_content_comment('tOboGo_PositiveRegulationOfRetroviralGenomeReplication',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","retroviral","genome","replication","."),4090413). assertion_content_comment('tOboGo_PositiveRegulationOfRhodopsinGeneExpression',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","rhodopsin","gene","expression","."),4298335). assertion_content_comment('tOboGo_PositiveRegulationOfRhoGTPaseActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","GTPase","of","the","Rho","family","."),4317909). assertion_content_comment('tOboGo_PositiveRegulationOfRhoProteinSignalTransduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Rho","protein","signal","transduction","."),4072589). assertion_content_comment('tOboGo_PositiveRegulationOfRibonucleoproteinComplexLocalization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ribonucleoprotein","complex","localization","."),4141140). assertion_content_comment('tOboGo_PositiveRegulationOfRibosomalLargeSubunitExportFromNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ribosomal","large","subunit","export","from","nucleus","."),4141277). assertion_content_comment('tOboGo_PositiveRegulationOfRibosomalProteinGeneTranscriptionFromRNAPolymeraseIIPromoter',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","synthesis","of","RNA","from","ribosomal","protein","genes","by","RNA","polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter","."),4156693). assertion_content_comment('tOboGo_PositiveRegulationOfRibosomalSmallSubunitExportFromNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ribosomal","small","subunit","export","from","nucleus","."),4141157). assertion_content_comment('tOboGo_PositiveRegulationOfRibosomalSubunitExportFromNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ribosomal","subunit","export","from","nucleus","."),4141148). assertion_content_comment('tOboGo_PositiveRegulationOfRibosomeBiogenesis',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","ribosome","biogenesis",".","Ribosome","biogenesis","is","the","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","ribosome","subunits","."),4150180). assertion_content_comment('tOboGo_PositiveRegulationOfRNAExportFromNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","directed","movement","of","RNA","from","the","nucleus","into","the","cytoplasm","."),4099506). assertion_content_comment('tOboGo_PositiveRegulationOfRNAImportIntoNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","movement","of","RNA","from","the","cytoplasm","into","the","nucleus","."),4099593). assertion_content_comment('tOboGo_PositiveRegulationOfRNAMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","RNA","."),3979711). assertion_content_comment('tOboGo_PositiveRegulationOfRNAPolymeraseIITranscriptionalPreinitiationComplexAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","RNA","polymerase","II","transcriptional","preinitiation","complex","assembly","."),4089958). assertion_content_comment('tOboGo_PositiveRegulationOfRNASplicing',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","RNA","splicing","."),4065893). assertion_content_comment('tOboGo_PositiveRegulationOfRoundaboutSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","Roundabout","signaling","pathway","."),4083198). assertion_content_comment('tOboGo_PositiveRegulationOfRRNAProcessing',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","rRNA","processing","."),4140652). assertion_content_comment('tOboGo_PositiveRegulationOfSalicylicAcidMediatedSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","salicylic","acid","mediated","signal","transduction","."),4147911). assertion_content_comment('tOboGo_PositiveRegulationOfSalivaryGlandBoundarySpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","salivary","gland","determination","."),4091322). assertion_content_comment('tOboGo_PositiveRegulationOfSalivaSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","saliva","."),4099732). assertion_content_comment('tOboGo_PositiveRegulationOfSarcomereOrganization',s("Any","process","that","increases","the","rate",",","frequency","or","extent","myofibril","assembly","by","organization","of","muscle","actomyosin","into","sarcomeres",".","The","sarcomere","is","the","repeating","unit","of","a","myofibril","in","a","muscle","cell",",","composed","of","an","array","of","overlapping","thick","and","thin","filaments","between","two","adjacent","Z","discs","."),4115786). assertion_content_comment('tOboGo_PositiveRegulationOfSatelliteCellActivationInvolvedInSkeletalMuscleRegeneration',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","activation","of","satellite","cell","involved","in","skeletal","muscle","regeneration",".","The","activation","of","satellite","cell","is","the","process","that","initiates","satellite","cell","division","by","causing","it","to","move","from","quiescence","to","the","G1","stage","of","the","cell","cycle",".","The","cell","swells","and","there","are","a","number","of","other","small","changes",".","The","cells","then","start","to","divide",".","Following","cell","division","the","cells","will","differentiate","."),4040275). assertion_content_comment('tOboGo_PositiveRegulationOfSchwannCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Schwann","cell","differentiation","."),4039150). assertion_content_comment('tOboGo_PositiveRegulationOfSchwannCellProliferation',s("Any","process","that","increases","the","frequency","or","rate","of","the","multiplication","or","reproduction","of","Schwann","cells",",","resulting","in","the","expansion","of","their","population",".","Schwann","cells","are","a","type","of","glial","cell","in","the","peripheral","nervous","system","."),4028966). assertion_content_comment('tOboGo_PositiveRegulationOfSclerotomeDevelopment',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","progression","of","the","sclerotome","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","sclerotome","is","the","portion","of","the","somite","that","will","give","rise","to","a","vertebra","."),4136161). assertion_content_comment('tOboGo_PositiveRegulationOfSecondaryGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","secondary","growth","."),4143769). assertion_content_comment('tOboGo_PositiveRegulationOfSecondaryHeartFieldCardioblastProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cardioblast","proliferation","in","the","second","heart","field",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4157384). assertion_content_comment('tOboGo_PositiveRegulationOfSecretionOfLysosomalEnzymes',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","secretion","of","lysosomal","enzymes",",","the","controlled","release","of","lysosomal","enzymes","by","a","cell","or","group","of","cells","."),4150671). assertion_content_comment('tOboGo_PositiveRegulationOfSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","controlled","release","of","a","substance","from","a","cell","or","group","of","cells","."),3988211). assertion_content_comment('tOboGo_PositiveRegulationOfSeedGermination',s("Any","process","that","activates","or","increase","the","rate","of","seed","germination","."),4032780). assertion_content_comment('tOboGo_PositiveRegulationOfSeptationInitiationSignalingCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","septation","initiation","signaling","."),4060968). assertion_content_comment('tOboGo_PositiveRegulationOfSequesteringOfCalciumIon',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","binding","or","confining","calcium","ions","such","that","they","are","separated","from","other","components","of","a","biological","system","."),4118051). assertion_content_comment('tOboGo_PositiveRegulationOfSequesteringOfTriglyceride',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","sequestering","of","triglyceride",".","Triglyceride","sequestration","is","the","process","of","binding","or","confining","any","triester","of","glycerol","such","that","it","is","separated","from","other","components","of","a","biological","system","."),4037588). assertion_content_comment('tOboGo_PositiveRegulationOfSequesteringOfZincIon',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","sequestering","of","zinc","ion",".","Sequestering","of","zinc","ion","is","the","process","of","binding","or","confining","zinc","ions","such","that","they","are","separated","from","other","components","of","a","biological","system","."),4135440). assertion_content_comment('tOboGo_PositiveRegulationOfSerotoninSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","serotonin","."),4039899). assertion_content_comment('tOboGo_PositiveRegulationOfSerotoninUptake',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","serotonin","into","a","cell","."),4121647). assertion_content_comment('tOboGo_PositiveRegulationOfSevenlessSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","sevenless","signaling","pathway","."),4090429). assertion_content_comment('tOboGo_PositiveRegulationOfSexualSporulationResultingInFormationOfACellularSpore',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","formation","of","cellular","spores","derived","from","the","products","of","meiosis","."),4096552). assertion_content_comment('tOboGo_PositiveRegulationOfSignaling',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","a","signaling","process","."),3987786). assertion_content_comment('tOboGo_PositiveRegulationOfSignalTransductionInResponseToHost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152283). assertion_content_comment('tOboGo_PositiveRegulationOfSignalTransductionInvolvedInConjugationWithCellularFusion',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","series","of","molecular","signals","that","bring","about","the","relay",",","amplification","or","dampening","of","a","signal","generated","in","response","to","a","cue",",","such","as","starvation","or","pheromone","exposure",",","in","organisms","that","undergo","conjugation","with","cellular","fusion","."),4115316). assertion_content_comment('tOboGo_PositiveRegulationOfSignalTransduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","."),3987792). assertion_content_comment('tOboGo_PositiveRegulationOfSisterChromatidCohesion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","sister","chromatid","cohesion","."),4076025). assertion_content_comment('tOboGo_PositiveRegulationOfSiteSelectionInvolvedInCellCycleCytokinesis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","site","selection","involved","in","cell","cycle","cytokinesis","."),4138517). assertion_content_comment('tOboGo_PositiveRegulationOfSkeletalMuscleCellProliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","skeletal","muscle","cell","proliferation","."),4038675). assertion_content_comment('tOboGo_PositiveRegulationOfSkeletalMuscleContractionByRegulationOfReleaseOfSequesteredCalciumIon',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","skeletal","muscle","contraction","via","the","regulation","of","the","release","of","sequestered","calcium","ion","by","sarcoplasmic","reticulum","into","cytosol",".","The","sarcoplasmic","reticulum","is","the","endoplasmic","reticulum","of","striated","muscle",",","specialised","for","the","sequestration","of","calcium","ions","that","are","released","upon","receipt","of","a","signal","relayed","by","the","T","tubules","from","the","neuromuscular","junction","."),4320801). assertion_content_comment('tOboGo_PositiveRegulationOfSkeletalMuscleFiberDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","skeletal","muscle","fiber","development",".","Muscle","fibers","are","formed","by","the","maturation","of","myotubes",".","They","can","be","classed","as","slow",",","intermediate/fast","or","fast","."),4104776). assertion_content_comment('tOboGo_PositiveRegulationOfSkeletalMuscleTissueDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","skeletal","muscle","tissue","development","."),4039790). assertion_content_comment('tOboGo_PositiveRegulationOfSkeletalMuscleTissueGrowth',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","skeletal","muscle","growth","."),4106599). assertion_content_comment('tOboGo_PositiveRegulationOfSkeletalMuscleTissueRegeneration',s("Any","process","that","activates","or","increase","the","rate","of","skeletal","muscle","regeneration","."),4040247). assertion_content_comment('tOboGo_PositiveRegulationOfSMADProteinImportIntoNucleus',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","SMAD","protein","import","into","the","nucleus",",","i.e",".","the","directed","movement","of","a","SMAD","proteins","from","the","cytoplasm","into","the","nucleus",".","Pathway-restricted","SMAD","proteins","and","common-partner","SMAD","proteins","are","involved","in","the","transforming","growth","factor","beta","receptor","signaling","pathways","."),4117306). assertion_content_comment('tOboGo_PositiveRegulationOfSmallGTPaseMediatedSignalTransduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","small","GTPase","mediated","signal","transduction","."),4056983). assertion_content_comment('tOboGo_PositiveRegulationOfSmoothenedSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","smoothened","signaling","."),4016112). assertion_content_comment('tOboGo_PositiveRegulationOfSmoothMuscleCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","smooth","muscle","cell","apoptosis","."),4074575). assertion_content_comment('tOboGo_PositiveRegulationOfSmoothMuscleCellChemotaxis',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","smooth","muscle","cell","chemotaxis","."),4128977). assertion_content_comment('tOboGo_PositiveRegulationOfSmoothMuscleCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","smooth","muscle","cell","differentiation","."),4119756). assertion_content_comment('tOboGo_PositiveRegulationOfSmoothMuscleCellMigration',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","smooth","muscle","cell","migration","."),4038799). assertion_content_comment('tOboGo_PositiveRegulationOfSmoothMuscleCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","smooth","muscle","cell","proliferation","."),4106699). assertion_content_comment('tOboGo_PositiveRegulationOfSmoothMuscleContraction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","smooth","muscle","contraction","."),4092202). assertion_content_comment('tOboGo_PositiveRegulationOfSNAREComplexAssembly',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","assembly","of","the","SNARE","complex",".","The","SNARE","complex","is","a","protein","complex","involved","in","membrane","fusion",";","a","stable","ternary","complex","consisting","of","a","four-helix","bundle",",","usually","formed","from","one","R-SNARE","and","three","Q-SNAREs","with","an","ionic","layer","sandwiched","between","hydrophobic","layers","."),4083931). assertion_content_comment('tOboGo_PositiveRegulationOfSNAREComplexDisassembly',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","disassembly","of","the","SNARE","complex",".","The","SNARE","complex","is","a","protein","complex","involved","in","membrane","fusion",";","a","stable","ternary","complex","consisting","of","a","four-helix","bundle",",","usually","formed","from","one","R-SNARE","and","three","Q-SNAREs","with","an","ionic","layer","sandwiched","between","hydrophobic","layers","."),4083898). assertion_content_comment('tOboGo_PositiveRegulationOfSodium_HydrogenAntiporterActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","sodium",":","hydrogen","antiporter",",","which","catalyzes","the","reaction",":","Na","+","(","out",")","+","H","+","(","in",")","=","Na","+","(","in",")","+","H","+","(","out",")"),4335040). assertion_content_comment('tOboGo_PositiveRegulationOfSodiumIonTransport',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","sodium","ions","(","Na","+",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4025071). assertion_content_comment('tOboGo_PositiveRegulationOfSomatostatinSecretion',s("Any","process","that","increases","the","rate",",","frequency",",","extent","of","the","regulated","release","of","somatostatin","from","secretory","granules","in","the","D","cells","of","the","pancreas","."),4151765). assertion_content_comment('tOboGo_PositiveRegulationOfSomitomericTrunkMuscleDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","somitomeric","trunk","muscle","development",".","The","somitomeric","trunk","muscle","is","derived","from","somitomeric","mesoderm",".","The","muscle","begins","its","development","with","the","differentiation","of","the","muscle","cells","and","ends","with","the","mature","muscle","."),4039798). assertion_content_comment('tOboGo_PositiveRegulationOfSorocarpStalkCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","sorocarp","stalk","cell","differentiation",".","An","example","of","this","process","is","found","in","Dictyostelium","discoideum","."),4059651). assertion_content_comment('tOboGo_PositiveRegulationOfSpermatidNuclearDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","spermatid","nuclear","differentiation","."),4091806). assertion_content_comment('tOboGo_PositiveRegulationOfSpermMotilityInvolvedInCapacitation',s("The","process","in","which","the","controlled","movement","of","a","sperm","cell","is","initiated","as","part","of","the","process","required","for","sperm","to","reach","fertilization","competence","."),4117873). assertion_content_comment('tOboGo_PositiveRegulationOfSPhaseOfMitoticCellCycle',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","S","phase","of","mitotic","cell","cycle","activity","."),4091019). assertion_content_comment('tOboGo_PositiveRegulationOfSphingolipidBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","sphingolipid","biosynthesis",".","Sphingolipid","biosynthesis","is","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","sphingolipids",",","any","of","a","class","of","lipids","containing","the","long-chain","amine","diol","sphingosine","or","a","closely","related","base","(","a","sphingoid",")"),4098416). assertion_content_comment('tOboGo_PositiveRegulationOfSpindleCheckpoint',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","spindle","checkpoint",",","a","cell","cycle","checkpoint","that","delays","the","metaphase/anaphase","transition","until","the","spindle","is","correctly","assembled","and","oriented",",","and","chromosomes","are","attached","to","the","spindle","."),4151606). assertion_content_comment('tOboGo_PositiveRegulationOfSpindlePoleBodySeparation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","process","involving","the","release","of","duplicated","spindle","pole","bodies","(","SPBs",")","and","their","migration","away","from","each","other","within","the","nuclear","membrane","."),4026762). assertion_content_comment('tOboGo_PositiveRegulationOfSporangiosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","sporangiospore","formation",",","a","process","in","which","sporangiospores",",","a","type","of","asexual","spore","found","in","fungi",",","are","formed",".","Sporangiospores","are","formed","within","sac-like","structure",",","the","sporangium",",","following","the","division","of","the","cytoplasm","."),4148277). assertion_content_comment('tOboGo_PositiveRegulationOfSporangiumDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","sporangium","development",",","a","process","that","leads","to","the","formation","of","sporangium",",","a","single-celled","or","many-celled","structure","in","which","spores","are","produced",",","as","in","fungi",",","algae",",","mosses",",","and","ferns",",","gymnosperms",",","angiosperms","."),4146395). assertion_content_comment('tOboGo_PositiveRegulationOfSporangiumGerminationOnOrNearHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","sporangium","germination","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146398). assertion_content_comment('tOboGo_PositiveRegulationOfSporeEncystmentOnHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","spore","encystment","on","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146198). assertion_content_comment('tOboGo_PositiveRegulationOfSporeGerminationOnOrNearHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","spore","germination","on","or","near","host",",","which","is","the","physiological",",","developmental","and","morphological","changes","that","occur","in","a","symbiont","spore","following","release","from","dormancy","up","to","the","earliest","signs","of","growth","occurring","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146324). assertion_content_comment('tOboGo_PositiveRegulationOfSporeMovementOnOrNearHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","spore","movement","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146488). assertion_content_comment('tOboGo_PositiveRegulationOfSporulationResultingInFormationOfACellularSpore',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","sporulation","."),4089813). assertion_content_comment('tOboGo_PositiveRegulationOfSporulation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","sporulation",",","the","process","whose","specific","outcome","is","the","progression","of","a","spore","over","time",",","from","its","initiation","to","the","mature","structure","."),4089809). assertion_content_comment('tOboGo_PositiveRegulationOfSproutingOfInjuredAxon',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","sprouting","of","an","injured","axon","."),4106913). assertion_content_comment('tOboGo_PositiveRegulationOfSTATProteinImportIntoNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","STAT","protein","import","into","nucleus","."),4142978). assertion_content_comment('tOboGo_PositiveRegulationOfSterigmatocystinBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","sterigmatocystin","biosynthesis",".","Sterigmatocystin","biosynthetic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","sterigmatocystin",",","a","carcinogenic","mycotoxin","produced","in","high","yields","by","strains","of","the","common","molds","."),4038392). assertion_content_comment('tOboGo_PositiveRegulationOfSteroidBiosyntheticProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","steroids",",","compounds","with","a","1",",","2",",","cyclopentanoperhydrophenanthrene","nucleus","."),4037747). assertion_content_comment('tOboGo_PositiveRegulationOfSteroidHormoneBiosyntheticProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","steroid","hormones",",","compounds","with","a","1",",","2",",","cyclopentanoperhydrophenanthrene","nucleus","that","act","as","hormones","."),4056073). assertion_content_comment('tOboGo_PositiveRegulationOfSteroidHormoneReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","activity","of","any","steroid","hormone","receptor","signaling","pathway","."),4065637). assertion_content_comment('tOboGo_PositiveRegulationOfSteroidMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","steroids","."),4037163). assertion_content_comment('tOboGo_PositiveRegulationOfSterolTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","sterols","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4037338). assertion_content_comment('tOboGo_PositiveRegulationOfStomatalComplexDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","stomatal","complex","development","."),4138129). assertion_content_comment('tOboGo_PositiveRegulationOfStressFiberAssembly',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","assembly","of","a","stress","fiber",",","a","bundle","of","microfilaments","and","other","proteins","found","in","fibroblasts","."),4119151). assertion_content_comment('tOboGo_PositiveRegulationOfStriatedMuscleCellApoptosis',s("Any","process","that","increases","the","rate","or","extent","of","striated","muscle","cell","apoptosis",".","Striated","muscle","cell","apoptosis","is","a","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","striated","muscle","cell","and","result","in","its","death","."),4026304). assertion_content_comment('tOboGo_PositiveRegulationOfStriatedMuscleCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","striated","muscle","cell","differentiation","."),4036616). assertion_content_comment('tOboGo_PositiveRegulationOfStriatedMuscleContraction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","striated","muscle","contraction","."),4040100). assertion_content_comment('tOboGo_PositiveRegulationOfStriatedMuscleTissueDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","striated","muscle","development","."),4039781). assertion_content_comment('tOboGo_PositiveRegulationOfSulfurAminoAcidMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","sulfur","amino","acids","."),4031251). assertion_content_comment('tOboGo_PositiveRegulationOfSulfurMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","sulfur","or","compounds","containing","sulfur","."),4031240). assertion_content_comment('tOboGo_PositiveRegulationOfSulfurUtilization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","sulfur","utilization","."),4089829). assertion_content_comment('tOboGo_PositiveRegulationOfSuperoxideAnionGeneration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","enzymatic","generation","of","superoxide","by","a","cell","."),4064168). assertion_content_comment('tOboGo_PositiveRegulationOfSurvivalGeneProductExpression',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","survival","gene","product","expression",";","survival","gene","products","are","those","that","antagonize","the","apoptotic","program",".","Regulation","can","be","at","the","transcriptional",",","translational",",","or","posttranslational","level","."),4298362). assertion_content_comment('tOboGo_PositiveRegulationOfSymbiontCellWallStrengtheningInvolvedInEntryIntoHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","cell","wall","strengthening","during","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147319). assertion_content_comment('tOboGo_PositiveRegulationOfSymbiontGermTubeHookStructureFormationOnOrNearHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","germ","tube","hook","structure","formation","on","or","near","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147456). assertion_content_comment('tOboGo_PositiveRegulationOfSymbiontHaustoriumNeckFormationForEntryIntoHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","haustorium","neck","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146097). assertion_content_comment('tOboGo_PositiveRegulationOfSymbiontInvasiveHyphaFormationInHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","invasive","hypha","formation","within","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147274). assertion_content_comment('tOboGo_PositiveRegulationOfSymbiontPenetrationHyphaFormationForEntryIntoHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","penetration","hypha","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146154). assertion_content_comment('tOboGo_PositiveRegulationOfSymbiontPenetrationPegFormationForEntryIntoHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","penetration","peg","formation","for","entry","into","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147221). assertion_content_comment('tOboGo_PositiveRegulationOfSymbiontPenetrationPegInitiation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","penetration","peg","initiation",",","the","process","in","which","a","relatively","unspecialized","cell","starts","to","acquire","the","characteristics","of","a","mature","penetration","peg","during","the","symbiont","penetrating","into","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147236). assertion_content_comment('tOboGo_PositiveRegulationOfSymbiontTranscriptionInResponseToHost',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","transcription","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152478). assertion_content_comment('tOboGo_PositiveRegulationOfSynapseMaturationBySynapticTransmission',s("Any","process","that","increases","the","extent","of","synaptic","maturation","as","a","result","of","the","communication","from","a","pre-synaptic","cell","to","a","post-synaptic","cell","across","a","synapse","."),4154735). assertion_content_comment('tOboGo_PositiveRegulationOfSynapseMaturation',s("Any","process","that","increases","the","extent","of","synapse","maturation",",","the","process","that","organizes","a","synapse","so","that","it","attains","its","fully","functional","state","."),4149071). assertion_content_comment('tOboGo_PositiveRegulationOfSynapseStructuralPlasticity',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","synaptic","structural","plasticity","."),4282774). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticGrowthAtNeuromuscularJunction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","synaptic","growth","at","neuromuscular","junction","."),4089908). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticMetaplasticity',s("A","process","that","increases","synaptic","metaplasticity",".","Metaplasticity","is","a","higher-order","form","of","plasticity","and","is","manifest","as","a","change","in","the","ability","to","induce","subsequent","synaptic","plasticity","that","is","the","ability","of","synapses","to","change","as","circumstances","require","."),4320274). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticPlasticityByChemicalSubstance',s("The","process","in","which","a","chemical","substance","increases","synaptic","plasticity",",","the","ability","of","synapses","to","change","as","circumstances","require","."),4183154). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticPlasticity',s("A","process","that","increases","synaptic","plasticity",",","the","ability","of","synapses","to","change","as","circumstances","require",".","They","may","alter","function",",","such","as","increasing","or","decreasing","their","sensitivity",",","or","they","may","increase","or","decrease","in","actual","numbers","."),4183135). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticTransmissionCholinergic',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","cholinergic","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","acetylcholine","."),4054372). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticTransmissionDopaminergic',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","dopaminergic","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","dopamine","."),4054356). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticTransmissionGABAergic',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","GABAergic","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","gamma-aminobutyric","acid","(","GABA",")"),4054453). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticTransmissionGlutamatergic',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","glutamatergic","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","glutamate","."),4120691). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticTransmissionGlycinergic',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","glycinergic","synaptic","transmission",".","Glycinergic","synaptic","transmission","is","the","process","of","communication","from","a","neuron","to","another","neuron","across","a","synapse","using","the","neurotransmitter","glycine","."),4108816). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticTransmission',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","synaptic","transmission",",","the","process","of","communication","from","a","neuron","to","a","target","(","neuron",",","muscle",",","or","secretory","cell",")","across","a","synapse","."),4054348). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticVesicleExocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","synaptic","vesicle","exocytosis","."),4139856). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticVesicleFusionToPresynapticMembrane',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","synaptic","vesicle","fusion","to","the","presynaptic","membrane","."),4059918). assertion_content_comment('tOboGo_PositiveRegulationOfSynapticVesiclePriming',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","synaptic","vesicle","priming",".","Synaptic","vesicle","priming","is","the","formation","of","SNARE-containing","complexes",",","bringing","synaptic","vesicle","membrane","and","plasma","membranes","into","close","proximity","and","thereby","facilitating","membrane","fusion","."),4025981). assertion_content_comment('tOboGo_PositiveRegulationOfSynaptogenesis',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","synaptogenesis",",","the","formation","of","a","synapse","."),4089900). assertion_content_comment('tOboGo_PositiveRegulationOfSyncytialBlastodermMitoticCellCycle',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","progression","through","the","syncytial","blastoderm","mitotic","cell","cycle","."),4091951). assertion_content_comment('tOboGo_PositiveRegulationOfSyncytiumFormationByPlasmaMembraneFusion',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","formation","of","a","syncytium",",","a","mass","of","cytoplasm","containing","several","nuclei","enclosed","within","a","single","plasma","membrane",",","by","the","fusion","of","the","plasma","membranes","of","two","or","more","individual","cells","."),4075754). assertion_content_comment('tOboGo_PositiveRegulationOfSyncytiumFormationByVirus',s("The","process","in","which","a","virus","increases","the","frequency",",","rate","or","extent","of","the","formation","of","a","syncytium",",","a","mass","of","cytoplasm","containing","several","nuclei","enclosed","within","a","single","plasma","membrane",",","by","the","fusion","of","the","plasma","membranes","of","two","or","more","individual","cells","."),4108181). assertion_content_comment('tOboGo_PositiveRegulationOfSynergidDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","synergid","cell","differentiation","."),4091758). assertion_content_comment('tOboGo_PositiveRegulationOfSystemicArterialBloodPressure',s("The","process","that","increases","the","force","with","which","blood","travels","through","the","systemic","arterial","circulatory","system","."),3991325). assertion_content_comment('tOboGo_PositiveRegulationOfTCellActivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T","cell","activation","."),4066280). assertion_content_comment('tOboGo_PositiveRegulationOfTCellAnergy',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","T","cell","anergy","."),3998308). assertion_content_comment('tOboGo_PositiveRegulationOfTCellAntigenProcessingAndPresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","T","cell","antigen","processing","and","presentation","."),3995726). assertion_content_comment('tOboGo_PositiveRegulationOfTCellApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T","cell","death","by","apoptosis","."),4137054). assertion_content_comment('tOboGo_PositiveRegulationOfTCellChemotaxis',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","T","cell","chemotaxis",".","T","cell","chemotaxis","is","the","directed","movement","of","a","T","cell","in","response","to","an","external","stimulus","."),4036509). assertion_content_comment('tOboGo_PositiveRegulationOfTCellCostimulation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T","cell","costimulation","."),4144736). assertion_content_comment('tOboGo_PositiveRegulationOfTCellCytokineProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","T","cell","cytokine","production","."),3998642). assertion_content_comment('tOboGo_PositiveRegulationOfTCellDifferentiationInThymus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T","cell","differentiation","in","the","thymus","."),4066303). assertion_content_comment('tOboGo_PositiveRegulationOfTCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T","cell","differentiation","."),4066291). assertion_content_comment('tOboGo_PositiveRegulationOfTCellExtravasation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T","cell","extravasation","."),4142183). assertion_content_comment('tOboGo_PositiveRegulationOfTCellHomeostaticProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","resting","T","cell","proliferation","."),4080909). assertion_content_comment('tOboGo_PositiveRegulationOfTCellMediatedCytotoxicityDirectedAgainstTumorCellTarget',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","T","cell","mediated","cytotoxicity","directed","against","a","tumor","cell","target","."),4000307). assertion_content_comment('tOboGo_PositiveRegulationOfTCellMediatedCytotoxicity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T","cell","mediated","cytotoxicity","."),3989528). assertion_content_comment('tOboGo_PositiveRegulationOfTCellMediatedImmuneResponseToTumorCell',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","T","cell","mediated","immune","response","to","tumor","cell","."),4000283). assertion_content_comment('tOboGo_PositiveRegulationOfTCellMediatedImmunity',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","T","cell","mediated","immunity","."),3984177). assertion_content_comment('tOboGo_PositiveRegulationOfTCellMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T","cell","migration","."),4036503). assertion_content_comment('tOboGo_PositiveRegulationOfTCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","T","cell","proliferation","."),4066327). assertion_content_comment('tOboGo_PositiveRegulationOfTCellReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","pathways","initiated","by","the","cross-linking","of","an","antigen","receptor","on","a","T","cell","."),4052408). assertion_content_comment('tOboGo_PositiveRegulationOfTCellToleranceInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","T","cell","tolerance","induction","."),3998255). assertion_content_comment('tOboGo_PositiveRegulationOfTCellToleranceInductionToTumorCell',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","T","cell","tolerance","induction","to","tumor","cell","."),4000468). assertion_content_comment('tOboGo_PositiveRegulationOfTeliosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","teliospore","formation",",","which","is","the","formation","of","a","thick-walled","resting","or","overwintering","spore","produced","by","the","rust","fungi","(","Uredinales",")","and","smut","fungi","(","Ustilaginales",")","in","which","karyogamy","occurs","."),4148528). assertion_content_comment('tOboGo_PositiveRegulationOfTeliumDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","telium","development",",","a","process","that","leads","to","the","formation","of","a","teliospore-bearing","sorus","of","the","rust","fungi","."),4148364). assertion_content_comment('tOboGo_PositiveRegulationOfTelomeraseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","telomerase","activity",",","the","catalysis","of","the","reaction",":","deoxynucleoside","triphosphate","+","DNA","(","n",")","=","diphosphate","+","DNA","(","n","+","1",")"),4183759). assertion_content_comment('tOboGo_PositiveRegulationOfTelomereMaintenance',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","process","that","affects","and","monitors","the","activity","of","telomeric","proteins","and","the","length","of","telomeric","DNA","."),4054114). assertion_content_comment('tOboGo_PositiveRegulationOfTelomereMaintenanceViaRecombination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","recombinational","process","involved","in","the","maintenance","of","proper","telomeric","length","."),4055249). assertion_content_comment('tOboGo_PositiveRegulationOfTelomereMaintenanceViaTelomerase',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","addition","of","telomeric","repeats","by","telomerase","."),4055158). assertion_content_comment('tOboGo_PositiveRegulationOfTerminalGapGeneTranscription',s("The","activation","of","genes","encoding","transcription","factors","at","the","anterior","and","posterior","ends","of","an","insect","embryo","by","a","combination","of","maternal","regulatory","signals","and","interactions","among","themselves",";","exemplified","by","the","activation","of","expression","of","the","Drosophila","tailless","and","huckebein","genes","."),4019405). assertion_content_comment('tOboGo_PositiveRegulationOfTheForceOfHeartContractionByChemicalSignal',s("Any","process","which","increases","the","force","of","heart","muscle","contraction","mediated","by","chemical","signaling",",","hormonal",",","autocrine","or","paracrine","."),3991562). assertion_content_comment('tOboGo_PositiveRegulationOfTheForceOfHeartContractionByCirculatingEpinephrine',s("The","process","in","which","the","secretion","of","epinephrine","into","the","bloodstream","modulates","the","force","of","heart","muscle","contraction","."),4003979). assertion_content_comment('tOboGo_PositiveRegulationOfTheForceOfHeartContractionByCirculatingNorepinephrine',s("The","process","in","which","the","secretion","of","norepinephrine","into","the","bloodstream","modulates","the","force","of","heart","muscle","contraction","."),4193715). assertion_content_comment('tOboGo_PositiveRegulationOfTheForceOfHeartContractionByEpinephrine',s("The","process","in","which","the","secretion","of","epinephrine","into","the","bloodstream","or","released","from","nerve","endings","modulates","the","force","of","heart","muscle","contraction","."),4003849). assertion_content_comment('tOboGo_PositiveRegulationOfTheForceOfHeartContractionByNeuronalEpinephrine',s("The","process","in","which","the","release","of","epinephrine","from","nerve","endings","modulates","the","force","of","heart","muscle","contraction","."),4004007). assertion_content_comment('tOboGo_PositiveRegulationOfTheForceOfHeartContractionByNeuronalNorepinephrine',s("The","process","in","which","the","release","of","norepinephrine","from","nerve","endings","modulates","the","force","of","heart","muscle","contraction","."),4193795). assertion_content_comment('tOboGo_PositiveRegulationOfTheForceOfHeartContractionByNorepinephrine',s("The","process","in","which","the","secretion","of","norepinephrine","into","the","bloodstream","or","released","from","nerve","endings","modulates","the","force","of","heart","musclecontraction","."),4003865). assertion_content_comment('tOboGo_PositiveRegulationOfTheForceOfHeartContractionInvolvedInBaroreceptorResponseToDecreasedSystemicArterialBloodPressure',s("Any","process","that","increases","the","force","with","which","the","cardiac","muscles","of","the","heart","pump","blood","through","the","circulatory","system","as","part","of","the","baroreceptor","response","to","decreased","blood","pressure","."),3991890). assertion_content_comment('tOboGo_PositiveRegulationOfThiamineBiosyntheticProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","thiamine","."),4149390). assertion_content_comment('tOboGo_PositiveRegulationOfThrombinReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","thrombin","receptor","protein","signaling","pathway","activity",".","A","thrombin","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","a","thrombin","receptor","binding","to","one","of","its","physiological","ligands","."),4131274). assertion_content_comment('tOboGo_PositiveRegulationOfThymidylateSynthaseBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","enzyme","thymidylate","synthase","."),4101105). assertion_content_comment('tOboGo_PositiveRegulationOfThymineTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","thymine",",","5-methyluracil",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083343). assertion_content_comment('tOboGo_PositiveRegulationOfThymocyteAggregation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","thymocyte","aggregation","."),4142668). assertion_content_comment('tOboGo_PositiveRegulationOfThymocyteApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","thymocyte","death","by","apoptosis","."),4137067). assertion_content_comment('tOboGo_PositiveRegulationOfThymocyteMigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","thymocyte","migration","."),4142812). assertion_content_comment('tOboGo_PositiveRegulationOfThyroidHormoneGeneration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","thyroid","hormone","generation","."),4143716). assertion_content_comment('tOboGo_PositiveRegulationOfThyroidHormoneMediatedSignalingPathway',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","thyroid","hormone","mediated","signaling","pathway","."),3992951). assertion_content_comment('tOboGo_PositiveRegulationOfTissueRemodeling',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","tissue","remodeling","."),4076680). assertion_content_comment('tOboGo_PositiveRegulationOfToleranceInductionDependentUponImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","tolerance","induction","dependent","upon","immune","response","."),3995249). assertion_content_comment('tOboGo_PositiveRegulationOfToleranceInduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","tolerance","induction","."),3995155). assertion_content_comment('tOboGo_PositiveRegulationOfToleranceInductionToNonselfAntigen',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","tolerance","induction","to","nonself","antigen","."),3995355). assertion_content_comment('tOboGo_PositiveRegulationOfToleranceInductionToSelfAntigen',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","tolerance","induction","to","self","antigen","."),3995447). assertion_content_comment('tOboGo_PositiveRegulationOfToleranceInductionToTumorCell',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","tolerance","induction","to","tumor","cell","."),4000445). assertion_content_comment('tOboGo_PositiveRegulationOfTollSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","Tl","signaling","pathway","."),4091203). assertion_content_comment('tOboGo_PositiveRegulationOfTonicSkeletalMuscleContraction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","tonic","skeletal","muscle","contraction","."),4040108). assertion_content_comment('tOboGo_PositiveRegulationOfToothMineralization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","tooth","mineralization",",","the","deposition","of","calcium","salts","in","tooth","structures","."),4133399). assertion_content_comment('tOboGo_PositiveRegulationOfTORSignalingCascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","via","the","TOR","signaling","pathway","."),4057822). assertion_content_comment('tOboGo_PositiveRegulationOfTRAILBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","TRAIL",",","TNF-related","apoptosis","inducing","ligand","."),4088115). assertion_content_comment('tOboGo_PositiveRegulationOfTRAILProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","TRAIL","production","."),4069432). assertion_content_comment('tOboGo_PositiveRegulationOfTRAILReceptor1BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","TRAIL","(","TNF-related","apoptosis","inducing","ligand",")","receptor","1","."),4088066). assertion_content_comment('tOboGo_PositiveRegulationOfTRAILReceptor2BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","TRAIL","(","TNF-related","apoptosis","inducing","ligand",")","receptor","2","."),4088008). assertion_content_comment('tOboGo_PositiveRegulationOfTRAILReceptorBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","TRAIL","(","TNF-related","apoptosis","inducing","ligand",")","receptor","."),4087836). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionByGalactose',s("Any","process","involving","galactose","that","activates","or","increases","the","rate","of","transcription","."),4362644). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionByGlucose',s("Any","process","involving","glucose","that","activates","or","increases","the","rate","of","transcription","."),4348217). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionByPheromones',s("Any","process","involving","pheromones","that","activates","or","increases","the","rate","of","transcription","."),4235756). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionDuringMeiosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","during","meiosis","."),4286966). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionDuringMitosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","during","mitosis","."),4298264). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionElongationFromRNAPolymeraseIIPromoter',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","elongation",",","the","extension","of","an","RNA","molecule","after","transcription","initiation","and","promoter","clearance","by","the","addition","of","ribonucleotides",",","catalyzed","by","RNA","polymerase","II","."),4065335). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFactorImportIntoNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","movement","of","a","transcription","factor","from","the","cytoplasm","to","the","nucleus","."),4020188). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIIPromoterDuringMitosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","III","promoter","during","mitosis","."),4348133). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIIPromoter',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","from","the","RNA","polymerase","III","promoter","."),4092720). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoterByGalactose',s("Any","process","involving","galactose","that","activates","or","increases","the","rate","of","transcription","from","an","RNA","polymerase","II","promoter","."),4362663). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoterByGlucose',s("Any","process","involving","glucose","that","activates","or","increases","the","rate","of","transcription","from","an","RNA","polymerase","II","promoter","."),4362733). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoterByPheromones',s("Any","process","involving","pheromones","that","activates","or","increases","the","rate","of","transcription","from","an","RNA","polymerase","II","promoter","."),4235776). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoterDuringMeiosis',s("A","cell","cycle","process","that","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","during","meiosis","."),4336406). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoterDuringMitosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","during","mitosis","."),4348152). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoterGlobal',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","global","transcription","from","an","RNA","polymerase","II","promoter","."),4297707). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoterInResponseToIron',s("Any","process","that","increases","the","rate","of","transcription","from","an","RNA","polymerase","II","promoter","in","response","to","an","iron","stimulus","."),4336710). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoterInvolvedInMyocardialPrecursorCellDifferentiation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","that","contributes","to","the","differentiation","of","a","myocardial","precursor","cell","."),4194312). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIIPromoter',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","from","the","RNA","polymerase","II","promoter","."),4013605). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIPromoterDuringMitosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","I","promoter","during","mitosis","."),4348233). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionFromRNAPolymeraseIPromoter',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","from","the","RNA","polymerase","I","promoter","."),4092687). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionInitiationFromRNAPolymeraseIIPromoter',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","a","process","involved","in","starting","transcription","from","the","RNA","polymerase","II","promoter","."),4116018). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionInvolvedInEggActivation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","transcription","as","a","part","of","the","process","of","egg","activation","."),4117894). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionInvolvedInG1SPhaseOfMitoticCellCycle',s("Any","process","that","activates","or","increases","transcription","as","part","of","the","G1/S","transition","of","the","mitotic","cell","cycle","."),4167987). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionOfHomeoticGenePolycombGroup',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","of","homeotic","genes","of","the","Polycomb","group","."),4298298). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionOfHomeoticGeneTrithoraxGroup',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","of","homeotic","genes","of","the","trithorax","group","."),4222418). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionOfNotchReceptorTarget',s("The","activation","of","transcription","of","specific","genes","as","a","result","of","Notch","signaling",",","mediated","by","the","Notch","intracellular","domain","."),4016191). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionOnExitFromMitosisFromRNAPolymeraseIIIPromoter',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","III","promoter","as","the","cell","leaves","M","phase",".","M","phase","is","the","part","of","the","mitotic","cell","cycle","during","which","mitosis","and","cytokinesis","take","place","."),4235108). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionOnExitFromMitosisFromRNAPolymeraseIIPromoter',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","as","the","cell","leaves","M","phase",".","M","phase","is","the","part","of","the","mitotic","cell","cycle","during","which","mitosis","and","cytokinesis","take","place","."),4235119). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionOnExitFromMitosisFromRNAPolymeraseIPromoter',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","I","promoter","as","the","cell","leaves","M","phase",".","M","phase","is","the","part","of","the","mitotic","cell","cycle","during","which","mitosis","and","cytokinesis","take","place","."),4235130). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionOnExitFromMitosis',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","transcription","as","the","cell","leaves","M","phase",".","M","phase","is","the","part","of","the","mitotic","cell","cycle","during","which","mitosis","and","cytokinesis","take","place","."),4012789). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionRegulatorActivity',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","transcription","regulator","activity",",","any","molecular","function","that","plays","a","role","in","regulating","transcription",";","may","bind","a","promoter","or","enhancer","DNA","sequence","or","interact","with","a","DNA-binding","transcription","factor","."),4013446). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionViaSerumResponseElementBinding',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","specifically","regulated","synthesis","of","RNA","from","DNA","encoding","a","specific","set","of","genes","as","a","result","of","a","transcription","factor","interacting","with","a","serum","response","element","(","SRE",")","A","serum","response","element","is","a","short","sequence","with","dyad","symmetry","found","in","the","promoters","of","some","of","the","cellular","immediate-early","genes",",","regulated","by","serum","."),4335840). assertion_content_comment('tOboGo_PositiveRegulationOfTranscriptionViaSterolRegulatoryElementBinding',s("The","process","in","which","a","sterol","regulatory","element","binding","protein","(","SREBP",")","mediates","an","increase","in","rate","or","extent","of","transcription","of","nuclear","target","genes","in","response","to","altered","levels","of","one","or","more","lipids",".","SREBPs","are","transcription","factors","that","bind","sterol","regulatory","elements","(","SREs",")",",","DNA","motifs","in","the","promoters","of","target","genes","."),4013748). assertion_content_comment('tOboGo_PositiveRegulationOfTransferaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transferase","activity",",","the","catalysis","of","the","transfer","of","a","group",",","e.g",".","a","methyl","group",",","glycosyl","group",",","acyl","group",",","phosphorus-containing",",","or","other","groups",",","from","a","donor","compound","to","an","acceptor","."),3972577). assertion_content_comment('tOboGo_PositiveRegulationOfTransformingGrowthFactorBetaReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","TGF-beta","receptor","signaling","pathway","activity","."),4046792). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationalElongation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translational","elongation","."),4090019). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationalFidelity',s("Any","process","that","increases","the","ability","of","the","translational","apparatus","to","interpret","the","genetic","code","."),4298107). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationalInitiationByIron',s("Any","process","involving","iron","that","activates","or","increases","the","rate","of","translational","initiation","."),4298023). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationalInitiationInResponseToOsmoticStress',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translation","initiation",",","as","a","result","of","a","stimulus","indicating","an","increase","or","decrease","in","the","concentration","of","solutes","outside","the","organism","or","cell","."),4330429). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationalInitiationInResponseToStarvation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translation","initiation",",","as","a","result","of","deprivation","of","nourishment","."),4165552). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationalInitiationInResponseToStress',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translation","initiation","as","a","result","of","a","stimulus","indicating","the","organism","is","under","stress","."),4165544). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationalInitiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translational","initiation","."),4092754). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationalTermination',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translational","termination","."),4090116). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationInResponseToNitrogenStarvation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translation","as","a","result","of","a","stimulus","indicating","deprivation","of","nitrogen","."),4172993). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationInResponseToOsmoticStress',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translation","as","a","result","of","a","stimulus","indicating","an","increase","or","decrease","in","the","concentration","of","solutes","outside","the","organism","or","cell","."),4330403). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationInResponseToOxidativeStress',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translation","as","a","result","of","oxidative","stress",",","a","state","often","resulting","from","exposure","to","high","levels","of","reactive","oxygen","species",",","e.g",".","superoxide","anions",",","hydrogen","peroxide","(","H2O2",")",",","and","hydroxyl","radicals","."),4336948). assertion_content_comment('tOboGo_PositiveRegulationOfTranslationInResponseToStress',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","translation","as","a","result","of","a","stimulus","indicating","the","organism","is","under","stress","."),4165535). assertion_content_comment('tOboGo_PositiveRegulationOfTranslation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","proteins","by","the","translation","of","mRNA","."),4090006). assertion_content_comment('tOboGo_PositiveRegulationOfTransmembraneReceptorProteinSerineThreonineKinaseSignalingPathway',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","series","of","molecular","signals","generated","as","a","consequence","of","a","transmembrane","receptor","serine/threonine","kinase","binding","to","its","physiological","ligand","."),4037089). assertion_content_comment('tOboGo_PositiveRegulationOfTransmembraneTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","solute","from","one","side","of","a","membrane","to","the","other","."),4020121). assertion_content_comment('tOboGo_PositiveRegulationOfTransmissionOfNerveImpulse',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","transmission","of","a","nerve","impulse",",","the","sequential","electrochemical","polarization","and","depolarization","that","travels","across","the","membrane","of","a","neuron","in","response","to","stimulation","."),4054341). assertion_content_comment('tOboGo_PositiveRegulationOfTransporterActivity',s("Any","process","that","activates","or","increases","the","activity","of","a","transporter","."),4160392). assertion_content_comment('tOboGo_PositiveRegulationOfTransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","(","such","as","macromolecules",",","small","molecules",",","ions",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3988203). assertion_content_comment('tOboGo_PositiveRegulationOfTransposition',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","transposition",".","Transposition","results","in","the","movement","of","discrete","segments","of","DNA","between","nonhomologous","sites","."),3975252). assertion_content_comment('tOboGo_PositiveRegulationOfTransposonIntegration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transposon","integration",",","a","process","in","which","a","transposable","element","is","incorporated","into","another","DNA","molecule","."),4132029). assertion_content_comment('tOboGo_PositiveRegulationOfTrichoblastFateSpecification',s("Any","process","that","induces","or","promotes","trichoblast","fate","specification","."),4032748). assertion_content_comment('tOboGo_PositiveRegulationOfTrichomeInitiationSensuMagnoliophyta',s("OBSOLETE",".","Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","trichome","initiation",";","as","in",",","but","not","restricted","to",",","the","flowering","plants","(","Magnoliophyta",",","ncbi_taxonomy_id",":","3398",")"),4331184). assertion_content_comment('tOboGo_PositiveRegulationOfTriglycerideBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","triglyceride","biosynthesis",".","Triglyceride","biosynthesis","is","the","collection","of","chemical","reactions","and","pathways","resulting","in","the","formation","of","triglyceride",",","any","triester","of","glycerol","."),4037272). assertion_content_comment('tOboGo_PositiveRegulationOfTriglycerideCatabolicProcess',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","triglyceride","."),4037881). assertion_content_comment('tOboGo_PositiveRegulationOfTriglycerideLipaseActivity',s("Any","process","that","increases","the","activity","of","triglyceride","lipase","."),4261471). assertion_content_comment('tOboGo_PositiveRegulationOfTriglycerideMetabolicProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","triglyceride",",","any","triester","of","glycerol","."),4037269). assertion_content_comment('tOboGo_PositiveRegulationOfTRNAExportFromNucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","tRNA","export","from","nucleus","."),4140564). assertion_content_comment('tOboGo_PositiveRegulationOfTRNAProcessing',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","tRNA","processing","."),4140688). assertion_content_comment('tOboGo_PositiveRegulationOfTryptophanMetabolicProcess',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","tryptophan",",","the","chiral","amino","acid","2-amino-3-","(","1H-indol-3-yl",")","propanoic","acid","."),4150849). assertion_content_comment('tOboGo_PositiveRegulationOfTubulinDeacetylation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","tubulin","deacetylation",".","Tubulin","deacetylation","is","the","removal","of","an","acetyl","group","from","a","protein","amino","acid","."),4149912). assertion_content_comment('tOboGo_PositiveRegulationOfTumorNecrosisFactorBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","tumor","necrosis","factor",",","an","inflammatory","cytokine","produced","by","macrophages/monocytes","during","acute","inflammation","and","which","is","responsible","for","a","diverse","range","of","signaling","events","within","cells",",","leading","to","necrosis","or","apoptosis","."),4079024). assertion_content_comment('tOboGo_PositiveRegulationOfTumorNecrosisFactorLigandSuperfamilyMember11Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","tumor","necrosis","factor","(","ligand",")","superfamily","member","11","production","."),4139782). assertion_content_comment('tOboGo_PositiveRegulationOfTumorNecrosisFactorProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","tumor","necrosis","factor","production","."),4068909). assertion_content_comment('tOboGo_PositiveRegulationOfTurningBehaviorInvolvedInMating',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","turning","behavior","involved","in","mating",".","Turning","behavior","is","the","sharp","ventral","turn","performed","by","the","male","as","he","approaches","either","the","hermaphrodite","head","or","tail",",","whilst","trying","to","locate","his","partner","'","s","vulva",".","Turning","occurs","via","a","sharp","ventral","coil","of","the","male","'","s","tail","."),4135430). assertion_content_comment('tOboGo_PositiveRegulationOfType2ImmuneResponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","type","2","immune","response","."),4000980). assertion_content_comment('tOboGo_PositiveRegulationOfTypeBPancreaticCellDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","pancreatic","B","cell","development","."),4138709). assertion_content_comment('tOboGo_PositiveRegulationOfTypeIHypersensitivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","type","I","hypersensitivity",",","a","type","of","inflammatory","response","."),3983685). assertion_content_comment('tOboGo_PositiveRegulationOfTypeIIaHypersensitivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","type","IIa","hypersensitivity",",","a","type","of","inflammatory","response","."),3984341). assertion_content_comment('tOboGo_PositiveRegulationOfTypeIIbHypersensitivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","type","IIb","hypersensitivity",",","a","type","of","inflammatory","response","."),3984529). assertion_content_comment('tOboGo_PositiveRegulationOfTypeIIHypersensitivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","type","II","hypersensitivity","."),3984333). assertion_content_comment('tOboGo_PositiveRegulationOfTypeIIIHypersensitivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","type","III","hypersensitivity",",","a","type","of","inflammatory","response","."),3984477). assertion_content_comment('tOboGo_PositiveRegulationOfTypeIIIInterferonProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","type","III","interferon","production",".","Type","III","interferons","are","members","of","the","interferon-lambda","gene","family","."),4075246). assertion_content_comment('tOboGo_PositiveRegulationOfTypeIInterferonProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","type","I","interferon","production",".","Type","I","interferons","include","the","interferon-alpha",",","beta",",","delta",",","episilon",",","zeta",",","kappa",",","tau",",","and","omega","gene","families","."),4055899). assertion_content_comment('tOboGo_PositiveRegulationOfTypeIVHypersensitivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","type","IV","hypersensitivity",",","a","type","of","inflammatory","response","."),3984189). assertion_content_comment('tOboGo_PositiveRegulationOfTyramineSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","tyramine","signaling","pathway","."),4138096). assertion_content_comment('tOboGo_PositiveRegulationOfTyrosinePhosphorylationOfStat1Protein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat1","protein","."),4079071). assertion_content_comment('tOboGo_PositiveRegulationOfTyrosinePhosphorylationOfStat2Protein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat2","protein","."),4079136). assertion_content_comment('tOboGo_PositiveRegulationOfTyrosinePhosphorylationOfStat3Protein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat3","protein","."),4079171). assertion_content_comment('tOboGo_PositiveRegulationOfTyrosinePhosphorylationOfStat4Protein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat4","protein","."),4079221). assertion_content_comment('tOboGo_PositiveRegulationOfTyrosinePhosphorylationOfStat5Protein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat5","protein","."),4078926). assertion_content_comment('tOboGo_PositiveRegulationOfTyrosinePhosphorylationOfStat6Protein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat6","protein","."),4078942). assertion_content_comment('tOboGo_PositiveRegulationOfTyrosinePhosphorylationOfStat7Protein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","Stat7","protein","."),4078977). assertion_content_comment('tOboGo_PositiveRegulationOfTyrosinePhosphorylationOfSTATProtein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","a","phosphate","group","to","a","tyrosine","residue","of","a","STAT","(","Signal","Transducer","and","Activator","of","Transcription",")","protein","."),4078918). assertion_content_comment('tOboGo_PositiveRegulationOfUnidimensionalCellGrowth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","unidimensional","cell","growth",",","the","process","in","which","a","cell","irreversibly","increases","in","size","in","one","[","spatial","]","dimension","or","along","one","axis","."),4118726). assertion_content_comment('tOboGo_PositiveRegulationOfUrediniumDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","uredinium","development",",","a","process","that","leads","to","the","formation","of","a","reddish",",","pustule-like","structure","formed","by","a","rust","fungus","and","consisting","of","uredospores","."),4148312). assertion_content_comment('tOboGo_PositiveRegulationOfUredosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","uredospore","formation",",","a","process","in","which","an","asexual",",","dikaryotic",",","often","rusty-colored","spore",",","is","formed","in","a","structure","called","a","uredinium","."),4148573). assertion_content_comment('tOboGo_PositiveRegulationOfUretericBudFormation',s("Any","process","that","increases","the","rate","or","extent","of","the","developmental","process","pertaining","to","the","initial","formation","of","the","ureteric","bud","from","the","Wolffian","duct","."),4124014). assertion_content_comment('tOboGo_PositiveRegulationOfUreterSmoothMuscleCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ureter","smooth","muscle","cell","differentiation","."),4138818). assertion_content_comment('tOboGo_PositiveRegulationOfUrineVolumeByPressureNatriuresis',s("An","increase","in","the","amount","of","urine","excreted","over","a","unit","of","time",",","as","a","result","of","pressure","natriuresis","."),4289267). assertion_content_comment('tOboGo_PositiveRegulationOfUrineVolume',s("Any","process","that","increases","the","amount","of","urine","excreted","from","the","body","over","a","unit","of","time","."),4193579). assertion_content_comment('tOboGo_PositiveRegulationOfUrothelialCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","urothelial","cell","proliferation","."),4101475). assertion_content_comment('tOboGo_PositiveRegulationOfUterineSmoothMuscleContraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","uterine","smooth","muscle","contraction","."),4131472). assertion_content_comment('tOboGo_PositiveRegulationOfVacuoleOrganization',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","vacuole","."),4097867). assertion_content_comment('tOboGo_PositiveRegulationOfVascularEndothelialGrowthFactorReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","vascular","endothelial","growth","factor","receptor","signaling","pathway","activity","."),4061573). assertion_content_comment('tOboGo_PositiveRegulationOfVascularPermeability',s("Any","process","that","increases","the","extent","to","which","blood","vessels","can","be","pervaded","by","fluid","."),4317787). assertion_content_comment('tOboGo_PositiveRegulationOfVascularWoundHealing',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","blood","vessel","formation","when","new","vessels","emerge","from","the","proliferation","of","pre-existing","blood","vessels","and","contribute","to","the","series","of","events","that","restore","integrity","to","damaged","vasculature","."),4084567). assertion_content_comment('tOboGo_PositiveRegulationOfVasoconstriction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","vasoconstriction","."),4090050). assertion_content_comment('tOboGo_PositiveRegulationOfVasodilation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","vasodilation","."),4090081). assertion_content_comment('tOboGo_PositiveRegulationOfVernalizationResponse',s("Any","process","that","activates","or","induces","the","rate","of","the","vernalization","response",",","by","which","induction","of","flowering","is","normally","caused","by","extended","exposure","to","cold","temperatures","."),4031888). assertion_content_comment('tOboGo_PositiveRegulationOfVesicleFusion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","vesicle","fusion","."),4059304). assertion_content_comment('tOboGo_PositiveRegulationOfViralGenomeReplication',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","viral","genome","replication","."),4090404). assertion_content_comment('tOboGo_PositiveRegulationOfViralProteinLevelsInHostCell',s("Any","process","that","increases","the","levels","of","viral","proteins","in","a","cell","."),4356999). assertion_content_comment('tOboGo_PositiveRegulationOfViralReproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","viral","life","cycle",",","the","set","of","processes","by","which","a","virus","reproduces","and","spreads","among","hosts","."),4064768). assertion_content_comment('tOboGo_PositiveRegulationOfViralTranscription',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","viral","transcription","."),4099886). assertion_content_comment('tOboGo_PositiveRegulationOfVirionPenetrationIntoHostCell',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","introduction","of","virus","particles","into","the","cell","."),4098778). assertion_content_comment('tOboGo_PositiveRegulationOfVitaminDBiosyntheticProcess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","a","vitamin","D","biosynthetic","process",".","Vitamin","D","biosynthesis","is","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","vitamin","D",",","any","of","a","group","of","related",",","fat-soluble","compounds","that","are","derived","from","delta-5",",","7","steroids","and","play","a","central","role","in","calcium","metabolism",".","Specific","forms","of","vitamin","D","include","calciferol","(","ergocalciferol",";","vitamin","D2",")","and","cholecalciferol","(","calciol",";","vitamin","D3",")"),4117091). assertion_content_comment('tOboGo_PositiveRegulationOfVitaminDReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","vitamin","D","receptor","signaling","pathway","activity","."),4131190). assertion_content_comment('tOboGo_PositiveRegulationOfVitaminMetabolicProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","vitamin",",","one","of","a","number","of","unrelated","organic","substances","that","occur","in","many","foods","in","small","amounts","and","that","are","necessary","in","trace","amounts","for","the","normal","metabolic","functioning","of","the","body","."),4091840). assertion_content_comment('tOboGo_PositiveRegulationOfVulvalDevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","development","of","the","vulva",".","Vulval","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","egg-laying","organ","of","female","and","hermaphrodite","nematodes","over","time",",","from","its","formation","to","the","mature","structure",".","In","nematodes",",","the","vulva","is","formed","from","ventral","epidermal","cells","during","larval","stages","to","give","rise","to","a","fully","formed","vulva","in","the","adult","."),4081881). assertion_content_comment('tOboGo_PositiveRegulationOfWhiteFatCellProliferation',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","white","fat","cell","proliferation","."),4136705). assertion_content_comment('tOboGo_PositiveRegulationOfWntProteinSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","controlled","release","of","a","Wnt","protein","from","a","cell","or","group","of","cells","."),4133767). assertion_content_comment('tOboGo_PositiveRegulationOfWNTReceptorSignalingPathwayByBMPSignalingPathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","results","in","an","increase","in","the","rate",",","frequency","or","extent","of","a","WNT","receptor","signaling","pathway","."),4156531). assertion_content_comment('tOboGo_PositiveRegulationOfWntReceptorSignalingPathwayByEstablishmentOfWntProteinLocalizationInExtracellularRegion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","Wnt","receptor","signaling","pathway","by","the","directed","movement","of","a","Wnt","protein","within","the","extracellular","region","."),4379257). assertion_content_comment('tOboGo_PositiveRegulationOfWntReceptorSignalingPathwayCalciumModulatingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","frizzled-2","signaling","pathway","."),4090543). assertion_content_comment('tOboGo_PositiveRegulationOfWntReceptorSignalingPathwayInvolvedInDorsalVentralAxisSpecification',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Wnt","receptor","signaling","pathway","involved","in","dorsal/ventral","axis","specification","."),4139164). assertion_content_comment('tOboGo_PositiveRegulationOfWntReceptorSignalingPathwayPlanarCellPolarityPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Wnt","receptor","signaling","pathway",",","planar","cell","polarity","pathway","."),4138477). assertion_content_comment('tOboGo_PositiveRegulationOfWntReceptorSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Wnt","receptor","signaling","pathway","activity","."),4047206). assertion_content_comment('tOboGo_PositiveRegulationOfWoundHealing',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","series","of","events","that","restore","integrity","to","a","damaged","tissue",",","following","an","injury","."),4084564). assertion_content_comment('tOboGo_PositiveRegulationOfXanthophoreDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","xanthophore","differentiation","."),4100081). assertion_content_comment('tOboGo_PositiveRegulationOfZoosporeEncystmentOnHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","zoospore","encystment","on","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146250). assertion_content_comment('tOboGo_PositiveRegulationOfZoosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","zoospore","formation",",","a","process","in","which","a","diploid","cell","undergoes","meiosis",",","and","the","meiotic","products","acquire","specialized","features","of","asexual","motile","mononucleate","flagellated","spores","called","zoospores","."),4148697). assertion_content_comment('tOboGo_PositiveRegulationOfZoosporeMovementOnOrNearHost',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","zoospore","movement","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146555). assertion_content_comment('tOboGo_PositiveRegulationOfZygosporangiumDevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","zygosporangium","development",",","a","process","in","which","a","fruiting","body","called","zygosporangium","is","formed","."),4148394). assertion_content_comment('tOboGo_PositiveRegulationOfZygosporeFormation',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","frequency",",","rate","or","extent","of","zygospore","formation",",","a","process","in","which","a","thick-walled","spore","of","some","algae","and","fungi","is","formed","by","union","of","two","similar","sexual","cells",",","usually","serves","as","a","resting","spore",",","and","produces","the","sporophytic","phase","."),4148176). assertion_content_comment('tOboGo_PositiveRegulationVascularEndothelialGrowthFactorProduction',s("Any","process","that","increases","or","activates","the","frequency",",","rate",",","or","extent","of","production","of","vascular","endothelial","growth","factor","."),4027414). assertion_content_comment('tOboGo_PositiveSenseViralGenome',s("A","single","stranded","RNA","genome","with","the","same","nucleotide","polarity","as","mRNA","."),4236447). assertion_content_comment('tOboGo_PositiveTCellSelection',s("The","process","of","sparing","immature","T","cells","which","react","with","self-MHC","protein","complexes","with","low","affinity","levels","from","apoptotic","death","."),4095458). assertion_content_comment('tOboGo_PositiveThymicTCellSelection',s("The","process","of","sparing","immature","T","cells","in","the","thymus","which","react","with","self-MHC","protein","complexes","with","low","affinity","levels","from","apoptotic","death","."),4301023). assertion_content_comment('tOboGo_PositiveTranscriptionElongationFactorActivity',s("Any","activity","that","increases","the","rate","of","transcription","elongation",",","the","addition","of","ribonucleotides","to","an","RNA","molecule","following","transcription","initiation","."),4245721). assertion_content_comment('tOboGo_PositiveTranscriptionElongationFactorComplexB',s("A","transcription","elongation","factor","complex","that","facilitates","the","transition","from","abortive","to","productive","elongation","by","phosphorylating","the","CTD","domain","of","the","large","subunit","of","DNA-directed","RNA","polymerase","II",",","holoenzyme",".","Contains","cyclin","T","and","a","cyclin-dependent","protein","kinase","catalytic","subunit","."),4177249). assertion_content_comment('tOboGo_PosteriorAbdomenDetermination',s("The","regionalization","process","in","which","the","posterior","(","abdominal",")","regions","of","the","embryo","are","specified","by","the","gap","genes","."),4019280). assertion_content_comment('tOboGo_PosteriorCibarialPlateDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","cibarial","plate","over","time",",","from","its","formation","to","the","mature","structure","."),4107282). assertion_content_comment('tOboGo_PosteriorCibarialPlateMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","posterior","cibarial","plate","are","generated","and","organized","."),4107303). assertion_content_comment('tOboGo_PosteriorCommissureMorphogenesis',s("Generation","of","a","long","process","of","a","CNS","neuron",",","that","carries","efferent","(","outgoing",")","action","potentials","from","the","cell","body","in","the","midbrain","towards","target","cells","in","the","diencephalon","."),4047731). assertion_content_comment('tOboGo_PosteriorCompartmentSpecification',s("The","process","involved","in","the","specification","of","cell","identity","in","the","posterior","compartments","of","the","segmented","embryo","."),4234571). assertion_content_comment('tOboGo_PosteriorHeadSegmentation',s("Partitioning","the","posterior","region","of","the","head","anlage","into","gnathal","(","mandibular",",","maxillary","and","labial",")","segments",".","Unlike","the","anterior","head","(","procephalic",")","segments",",","formation","of","the","posterior","head","(","gnathal",")","segments","occurs","by","a","similar","mechanism","to","trunk","segmentation",",","where","a","cascade","of","gap","genes",",","pair-rule","genes","and","segment-polarity","genes","subdivide","the","embryo","into","progressively","smaller","domains","."),4019481). assertion_content_comment('tOboGo_PosteriorLateralLineDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","lateral","line","over","time",",","from","its","formation","to","the","mature","structure",".","The","posterior","lateral","line","consists","of","small","sensory","patches","(","neuromasts",")","located","superficially","on","the","skin","or","just","under","the","skin","in","fluid-filled","canals","on","the","body","and","trunk","of","all","fishes","and","most","amphibians",".","The","posterior","lateral","line","develops","from","cranial","ectodermal","placodes","situated","behind","the","ear","."),4082733). assertion_content_comment('tOboGo_PosteriorLateralLineGanglionDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","lateral","line","ganglion","over","time",",","from","its","formation","to","the","mature","structure",".","The","posterior","lateral","line","ganglion","develops","from","cranial","ectodermal","placodes","situated","behind","the","ear","."),4106076). assertion_content_comment('tOboGo_PosteriorLateralLineGanglionNeuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuron","of","the","posterior","lateral","line","ganglion","."),4106087). assertion_content_comment('tOboGo_PosteriorLateralLineNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","lateral","line","nerve","over","time",",","form","its","formation","to","the","mature","structure",".","The","posterior","lateral","line","nerve","innervates","hair","cells","of","the","PLL","and","projects","to","an","octavolateralis","column","in","the","hindbrain","that","consists","of","the","medial","octavolateralis","nucleus","(","MON",")",",","the","caudal","octavolateralis","nucleus",",","and","the","magnocellular","nucleus","."),4106002). assertion_content_comment('tOboGo_PosteriorLateralLineNerveGlialCellDevelopment',s("The","process","aimed","at","the","progression","of","a","glial","cell","in","the","posterior","lateral","line","nerve","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4106016). assertion_content_comment('tOboGo_PosteriorLateralLineNerveGlialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","glial","cell","in","the","posterior","lateral","line","nerve","."),4106006). assertion_content_comment('tOboGo_PosteriorLateralLineNerveGlialCellMorphogenesisInvolvedInDifferentiation',s("The","process","in","which","the","structures","of","a","glial","cell","in","the","posterior","lateral","line","nerve","are","generated","and","organized",".","This","process","occurs","while","the","initially","relatively","unspecialized","cell","is","acquiring","the","specialized","features","of","a","glial","cell","in","the","posterior","lateral","line","nerve","."),4106036). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastCupulaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","lateral","line","neuromast","cupula","over","time",",","from","its","formation","to","the","mature","structure",".","The","cupula","is","secreted","by","mantle","cells","and","the","ciliary","bundles","of","all","of","the","hair","cells","of","the","neuromast","are","embedded","in","it",".","The","cupula","provides","a","mechanical","linkage","between","the","hair","cells","and","the","external","hydrodynamic","environment",".","The","cupula","of","superficial","neuromasts","grows","continuously",",","while","the","height","of","the","cupula","of","canal","neuromasts","is","limited","by","canal","diameter","."),4106117). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastDeposition',s("The","process","in","which","a","migrating","neuromast","primordium","deposits","clusters","of","undifferentiated","cells","(","proneuromasts",")","along","its","migratory","path","in","the","developing","posterior","lateral","line","."),4106127). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","lateral","line","neuromast","over","time",",","from","its","formation","to","the","mature","structure",".","The","neuromast","is","the","sensory","receptor","of","the","anterior","lateral","line","system","and","is","composed","of","a","population","of","sensory","hair","cells",",","and","nonsensory","supporting","cells","and","mantle","cells",".","Neuromast","are","located","superficially","on","the","epithelium","or","in","lateral","line","canals","."),4082736). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastHairCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","posterior","lateral","line","neuromast","hair","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","neuromast","hair","cell","is","a","hair","cell","that","acts","as","a","sensory","receptor","of","the","neuromast",";","it","is","morphologically","polarized","as","a","result","of","the","relative","position","of","the","single","kinocilium","and","the","clusters","of","stereocilia","on","its","apical","surface",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","specific","fate","."),4082748). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastHairCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","posterior","lateral","line","neuromast","hair","cell",".","(","N.B",".","This","may","be","development","of","neuromast","hair","cell","type","or","a","set","of","cell","of","neuromast","hair","cell","type",".","This","will","involve","the","change","of","a","cell","or","set","of","cells","from","one","cell","identity","to","another",")","Hair","cells","are","the","sensory","receptors","of","the","neuromast","and","are","located","in","a","portion","of","the","neuromast","called","the","sensory","strip",".","Each","hair","cell","of","the","neuromast","is","morphologically","polarized","as","a","result","of","the","relative","position","of","the","single","kinocilium","and","the","clusters","of","stereocilia","on","its","apical","surface",".","There","are","approximately","seven","hair","cells","within","each","neuromast",",","with","each","hair","cell","innervated","by","afferent","and","efferent","neurons","."),4082738). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastHairCellMorphogenesis',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","when","a","posterior","lateral","line","neuromast","hair","cell","progresses","from","its","initial","formation","to","its","mature","state",".","A","neuromast","hair","cell","is","a","hair","cell","that","acts","as","a","sensory","receptor","of","the","neuromast",";","it","is","morphologically","polarized","as","a","result","of","the","relative","position","of","the","single","kinocilium","and","the","clusters","of","stereocilia","on","its","apical","surface","."),4082826). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastMantleCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","posterior","lateral","line","neuromast","mantle","cell",".","(","N.B",".","This","may","be","development","of","neuromast","mantle","cell","type","or","a","set","of","cells","of","neuromast","mantle","cell","type",".","This","will","involve","the","change","of","a","cell","or","set","of","cells","from","one","cell","identity","to","another",")","Mantle","cells","are","non-sensory","cells","that","surround","the","sensory","strip",",","separating","the","neuromast","from","the","epidermis",".","Mantle","cells","secrete","the","cupula","in","which","the","ciliary","bundles","of","all","of","the","hair","cells","are","embedded","."),4106137). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastPrimordiumMigration',s("The","migration","of","a","relatively","undifferentiated","cell","along","the","developing","posterior","lateral","line",",","originating","from","cranial","ectodermal","placodes","situated","behind","the","ear",".","The","neuromast","primordium","deposits","proneuromasts","along","the","lateral","line",",","from","which","the","neuromasts","will","develop","."),4106147). assertion_content_comment('tOboGo_PosteriorLateralLineNeuromastSupportCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","posterior","lateral","line","neuromast","support","cell",".","Support","cells","are","non-sensory","cells","of","the","neuromast","that","extend","between","the","sensory","hair","cells","from","the","basement","membrane","to","the","apical","surface",";","they","are","surrounded","by","mantle","cells","."),4106066). assertion_content_comment('tOboGo_PosteriorLateralLineSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","lateral","line","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","posterior","lateral","line","system","develops","from","cranial","ectodermal","placodes",",","situated","behind","the","ear",",","that","give","rise","to","both","the","neuromasts","and","the","posterior","lateral","line","sensory","nerves","that","innervate","the","neuromasts",".","The","posterior","lateral","line","system","consists","of","small","sensory","patches","(","neuromasts",")","located","superficially","on","the","skin","or","just","under","the","skin","in","fluid-filled","canals","on","the","head","of","all","fishes","and","most","amphibians",".","The","neuromasts","are","innervated","by","several","lateral","line","nerves",",","which","project","primarily","to","the","hindbrain",".","The","posterior","mechanosensory","lateral","line","system","is","stimulated","by","local","water","displacements","and","vibrations",",","and","detects","propulsion","of","the","fish","through","the","water",",","as","well","as","facilitating","shoaling",",","prey","capture",",","and","predator","and","obstacle","avoidance","."),4082730). assertion_content_comment('tOboGo_PosteriorMalpighianTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","Malpighian","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","pair","of","posterior","tubules","arise","from","a","ventrolateral","region","of","the","embryonic","hindgut","and","project","backwards","through","the","body","cavity",".","A","Malpighian","tubule","is","a","fine",",","thin-walled","excretory","tubule","in","insects","which","connects","with","the","posterior","part","of","the","gut","."),4261602). assertion_content_comment('tOboGo_PosteriorMesonephricTubuleDevelopment',s("The","progression","of","the","posterior","mesonephric","tubule","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","posterior","mesonephric","tubule","is","an","epithelial","tube","that","is","part","of","the","mesonephros","."),4123358). assertion_content_comment('tOboGo_PosteriorMidgutDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","posterior","midgut","over","time",",","from","its","formation","to","the","mature","structure","."),4018303). assertion_content_comment('tOboGo_PosteriorMidgutInvagination',s("Formation","of","a","cup-shaped","invagination","at","the","posterior","end","of","the","embryo",",","bringing","the","posterior","midgut","and","hindgut","primordia","into","the","interior","."),4019567). assertion_content_comment('tOboGo_PosteriorMRNALocalizationInvolvedInAnteriorPosteriorAxisSpecification',s("Any","process","in","which","a","mRNA","is","transported","to","and","maintained","in","the","oocyte","and/or","syncytial","embryo","contributing","to","the","specification","of","the","anterior/posterior","axis","."),4156314). assertion_content_comment('tOboGo_PosteriorNeuralPlateFormation',s("The","formation","of","posterior","end","of","the","flat",",","thickened","layer","of","ectodermal","cells","known","as","the","neural","plate","."),4110817). assertion_content_comment('tOboGo_PosteriorNeuroporeClosure',s("The","joining","together","of","the","neural","folds","of","the","caudal","opening","of","the","neural","tube",".","The","posterior","neuropore","appears","before","the","process","of","neural","tube","closure","is","complete","."),4041532). assertion_content_comment('tOboGo_PosteriorSemicircularCanalDevelopment',s("The","progession","of","the","posterior","semicircular","canal","from","its","initial","formation","to","the","mature","structure","."),4156413). assertion_content_comment('tOboGo_PostganglionicParasympatheticNervousSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","postganglionic","portion","of","the","parasympathetic","nervous","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","parasympathetic","nervous","system","is","one","of","the","two","divisions","of","the","vertebrate","autonomic","nervous","system",".","Parasympathetic","nerves","emerge","cranially","as","pre","ganglionic","fibers","from","oculomotor",",","facial",",","glossopharyngeal","and","vagus","and","from","the","sacral","region","of","the","spinal","cord",".","Most","neurons","are","cholinergic","and","responses","are","mediated","by","muscarinic","receptors",".","The","parasympathetic","system","innervates",",","for","example",":","salivary","glands",",","thoracic","and","abdominal","viscera",",","bladder","and","genitalia","."),4049355). assertion_content_comment('tOboGo_PostnatalOlfactoryBulbInterneuronMigration',s("The","migration","of","olfactory","bulb","interneuron","precursors","in","the","cerebral","cortex","that","occurs","after","birth","."),4051177). assertion_content_comment('tOboGo_PostreplicationRepair',s("The","conversion","of","DNA-damage","induced","single-stranded","gaps","into","large","molecular","weight","DNA","after","replication",".","Includes","pathways","that","remove","replication-blocking","lesions","in","conjunction","with","DNA","replication","."),4177564). assertion_content_comment('tOboGo_PostsynapticDensity',s("The","post","synaptic","density","is","a","region","that","lies","adjacent","to","the","cytoplasmic","face","of","the","postsynaptic","membrane","at","excitatory","synapse",".","It","forms","a","disc","that","consists","of","a","range","of","proteins","with","different","functions",",","some","of","which","contact","the","cytoplasmic","domains","of","ion","channels","in","the","postsynaptic","membrane",".","The","proteins","making","up","the","disc","include","receptors",",","and","structural","proteins","linked","to","the","actin","cytoskeleton",".","They","also","include","signalling","machinery",",","such","as","protein","kinases","and","phosphatases","."),4328013). assertion_content_comment('tOboGo_PostsynapticMembraneOrganization',s("The","maintenance","of","membrane","composition","in","a","postsynaptic","membrane",",","the","specialized","area","of","membrane","facing","the","presynaptic","membrane","on","the","tip","of","the","nerve","ending","and","separated","from","it","by","a","minute","cleft","(","the","synaptic","cleft",")"),4128453). assertion_content_comment('tOboGo_PostsynapticMembrane',s("A","specialized","area","of","membrane","facing","the","presynaptic","membrane","on","the","tip","of","the","nerve","ending","and","separated","from","it","by","a","minute","cleft","(","the","synaptic","cleft",")","Neurotransmitters","across","the","synaptic","cleft","and","transmit","the","signal","to","the","postsynaptic","membrane","."),4298976). assertion_content_comment('tOboGo_PosttranscriptionalGeneSilencingByRNA',s("Any","process","of","posttranscriptional","gene","inactivation","(","silencing",")","mediated","by","small","RNA","molecules","that","may","trigger","mRNA","degradation","or","negatively","regulate","translation","."),4028111). assertion_content_comment('tOboGo_PosttranscriptionalGeneSilencing',s("The","inactivation","of","gene","expression","by","a","posttranscriptional","mechanism","."),4028095). assertion_content_comment('tOboGo_PosttranscriptionalInsertionOrDeletionEditing',s("OBSOLETE",".","The","insertion","into","or","deletion","from","an","RNA","molecule","of","nucleotide","residues","not","encoded","in","DNA",";","takes","place","after","transcription","."),4305256). assertion_content_comment('tOboGo_PosttranscriptionalRegulationOfGeneExpressionByMRNALocalization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gene","expression","after","the","production","of","a","mRNA","transcript","by","its","transport","into",",","or","maintainance","in",",","a","specific","location","within","the","cell","."),4336347). assertion_content_comment('tOboGo_PosttranscriptionalRegulationOfGeneExpression',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gene","expression","after","the","production","of","an","RNA","transcript","."),4009599). assertion_content_comment('tOboGo_PosttranscriptionalTetheringOfRNAPolymeraseIIGeneDNAAtNuclearPeriphery',s("The","chromosome","organization","process","in","which","the","DNA","sequence","containing","a","gene","transcribed","by","RNA","polymerase","II","is","maintained","in","a","specific","location","at","the","nuclear","periphery","even","after","transcription","has","been","repressed","."),4363283). assertion_content_comment('tOboGo_PosttranslationalProteinTargetingToMembraneDocking',s("The","process","in","which","the","signal","sequence","of","a","translated","protein","binds","to","and","forms","a","complex","with","the","Sec","complex","."),4062527). assertion_content_comment('tOboGo_PosttranslationalProteinTargetingToMembrane',s("The","targeting","of","proteins","to","a","membrane","that","occurs","after","their","translation",".","Some","secretory","proteins","exhibit","posttranslational","transport","into","the","endoplasmic","reticulum","(","ER",")","lumen",":","they","are","synthesized","in","their","entirety","on","free","cytosolic","ribosomes","and","then","released","into","the","cytosol",",","where","they","are","bound","by","chaperones","which","keep","them","in","an","unfolded","state",",","and","subsequently","are","translocated","across","the","ER","membrane","."),4062501). assertion_content_comment('tOboGo_PosttranslationalProteinTargetingToMembraneTranslocation',s("The","process","in","which","a","protein","translocates","through","the","ER","membrane","posttranslationally","."),4062515). assertion_content_comment('tOboGo_Potassium_AminoAcidSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","amino","acid","(","out",")","+","K","+","(","out",")","=","amino","acid","(","in",")","+","K","+","(","in",")"),4268449). assertion_content_comment('tOboGo_PotassiumChannelActivity',s("Catalysis","of","facilitated","diffusion","of","a","potassium","ion","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel","without","evidence","for","a","carrier-mediated","mechanism","."),4159407). assertion_content_comment('tOboGo_PotassiumChannelInhibitorActivity',s("Stops",",","prevents",",","or","reduces","the","activity","of","a","potassium","channel","."),4173076). assertion_content_comment('tOboGo_PotassiumChannelRegulatorActivity',s("Modulates","the","activity","of","a","potassium","channel","."),4173074). assertion_content_comment('tOboGo_Potassium_ChlorideSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","K","+","(","out",")","+","Cl-","(","out",")","=","K","+","(","in",")","+","Cl-","(","in",")"),4295902). assertion_content_comment('tOboGo_Potassium_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","K","+","(","in",")","+","H","+","(","out",")","=","K","+","(","out",")","+","H","+","(","in",")"),4295747). assertion_content_comment('tOboGo_Potassium_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","K","+","(","out",")","+","H","+","(","out",")","=","K","+","(","in",")","+","H","+","(","in",")"),4295735). assertion_content_comment('tOboGo_PotassiumIonAntiporterActivity',s("Catalysis","of","the","active","transport","of","a","potassium","ion","across","a","membrane","by","a","mechanism","whereby","two","or","more","species","are","transported","in","opposite","directions","in","a","tightly","coupled","process","not","directly","linked","to","a","form","of","energy","other","than","chemiosmotic","energy","."),4256250). assertion_content_comment('tOboGo_PotassiumIonBinding',s("Interacting","selectively","and","non-covalently","with","potassium","(","K","+",")","ions","."),4307413). assertion_content_comment('tOboGo_PotassiumIonExport',s("The","directed","movement","of","potassium","ions","out","of","a","cell","or","organelle","."),4164000). assertion_content_comment('tOboGo_PotassiumIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","potassium","ions","within","an","organism","or","cell","."),4222132). assertion_content_comment('tOboGo_PotassiumIonImport',s("The","directed","movement","of","potassium","ions","into","a","cell","or","organelle","."),4334274). assertion_content_comment('tOboGo_PotassiumIonLeakChannelActivity',s("Catalysis","of","the","transport","of","a","potassium","ion","across","a","membrane","via","a","narrow","pore","channel","that","is","open","even","in","an","unstimulated","or","'","resting","'","state","."),4332952). assertion_content_comment('tOboGo_PotassiumIonSymporterActivity',s("Catalysis","of","the","active","transport","of","a","potassium","ion","across","a","membrane","by","a","mechanism","whereby","two","or","more","species","are","transported","together","in","the","same","direction","in","a","tightly","coupled","process","not","directly","linked","to","a","form","of","energy","other","than","chemiosmotic","energy","."),4260893). assertion_content_comment('tOboGo_PotassiumIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","potassium","ions","(","K","+",")","from","one","side","of","a","membrane","to","the","other","."),4219106). assertion_content_comment('tOboGo_PotassiumIonTransmembraneTransport',s("A","process","in","which","a","potassium","ion","is","transported","from","one","side","of","a","membrane","to","the","other","."),4163998). assertion_content_comment('tOboGo_PotassiumIonTransport',s("The","directed","movement","of","potassium","ions","(","K","+",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4093210). assertion_content_comment('tOboGo_PotassiumIonUniporterActivity',s("Catalysis","of","the","active","transport","of","a","potassium","ion","across","a","membrane","by","a","mechanism","involving","conformational","change",",","where","energy","for","active","transport","is","derived","from","membrane","potential","if","the","solute","is","charged","."),4331143). assertion_content_comment('tOboGo_Potassium_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","K","+","(","out",")","+","Na","+","(","out",")","=","K","+","(","in",")","+","Na","+","(","in",")"),4260895). assertion_content_comment('tOboGo_PotassiumUptakeTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","potassium","from","the","outside","of","a","cell","to","the","inside","of","the","cell","across","a","membrane",":","K","+","(","out",")","+","energy","=","K","+","(","in",")"),4295824). assertion_content_comment('tOboGo_PouchOutgrowthInvolvedInSemicircularCanalFormation',s("The","morphogenetic","process","in","which","an","epithelial","sheet","bends","along","a","linear","axis","and","gives","rise","to","a","pouch","that","will","form","a","semicircular","canal","."),4114015). assertion_content_comment('tOboGo_POUDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","POU","domain","of","a","protein",".","The","POU","domain","is","a","bipartite","DNA","binding","domain","composed","of","two","subunits","separated","by","a","non-conserved","region","of","15-55","amino","acids",";","it","is","found","in","several","eukaryotic","transcription","factors","."),4177730). assertion_content_comment('tOboGo_POZDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","POZ","(","poxvirus","and","zinc","finger",")","domain","of","a","protein",",","a","protein-protein","interaction","domain","found","in","many","transcription","factors","."),4319887). assertion_content_comment('tOboGo_PRC1Complex',s("An","insect","multiprotein","complex","containing","the","products","of","many","of","the","Polycomb","Group","genes","including","Polycomb",",","Posterior","sex","combs",",","polyhomeotic","and","Sex","comb","on","midleg",".","The","Polycomb","Group","proteins","are","required","for","stable","long-term","maintenance","of","transcriptionally","repressed","states","and","the","PRC1","complex","directly","antagonizes","ATP-dependent","remodeling","of","nucleosomal","arrays","."),4381927). assertion_content_comment('tOboGo_PreantralOvarianFollicleGrowth',s("Increase","in","size","of","follicles","surrounded","by","two","or","more","layers","of","granulosa","cells","up","to","the","onset","of","antrum","formation","."),3981867). assertion_content_comment('tOboGo_PreassemblyOfGPIAnchorInERMembrane',s("The","stepwise","addition","of","the","components","of","the","GPI","anchor","on","to","phosphatidylinositol","lipids","in","the","endoplasmic","reticulum","membrane","."),4034670). assertion_content_comment('tOboGo_PrebendSegmentDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","prebend","segment","over","time",",","from","its","formation","to","the","mature","structure",".","The","prebend","segment","is","a","part","of","the","descending","thin","limb","that","lies","before","the","bend","and","exhibits","permeabilities","characteristic","of","the","ascending","limb",",","especially","negligible","water","permeability","."),4123784). assertion_content_comment('tOboGo_PreblastodermMitoticCellCycle',s("The","first","nine","mitotic","division","cycles","of","the","insect","embryo",",","during","which","the","dividing","nuclei","lie","deep","in","the","interior","of","the","egg","and","divide","nearly","synchronously",".","This","is","the","first","phase","of","the","syncytial","period","where","nuclei","divide","in","a","common","cytoplasm","without","cytokinesis","."),4019119). assertion_content_comment('tOboGo_PrecatalyticSpliceosome',s("A","spliceosomal","complex","that","is","formed","by","the","recruitment","of","a","preassembled","U5-containing","tri-snRNP","to","the","prespliceosome",".","Although","all","5","snRNPs","are","present",",","the","precatalytic","spliceosome","is","catalytically","inactive",".","The","precatalytic","spliceosome","includes","many","proteins","in","addition","to","those","found","in","the","associated","snRNPs","."),4167668). assertion_content_comment('tOboGo_PrechordalPlateFormation',s("The","formation","of","the","prechordal","plate",".","The","prechordal","plate","is","a","thickening","of","the","endoderm","at","the","cranial","end","of","the","primitive","streak","formed","by","the","involution","of","Spemann","'","s","organizer","cells",".","The","prechordal","plate","and","the","notochord","induce","the","formation","of","the","neural","plate","from","the","overlying","ectodermal","cells","."),4041630). assertion_content_comment('tOboGo_PredatoryAggressiveBehavior',s("Aggressive","behavior","involving","attack","on","prey","by","a","predator","."),4375588). assertion_content_comment('tOboGo_PrefoldinComplex',s("A","multisubunit","chaperone","that","acts","to","delivers","unfolded","proteins","to","cytosolic","chaperonin",".","In","humans",",","the","complex","is","a","heterohexamer","of","two","PFD-alpha","and","four","PFD-beta","type","subunits","."),4303695). assertion_content_comment('tOboGo_PreganglionicParasympatheticNervousSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","preganglionic","portion","of","the","parasympathetic","nervous","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","parasympathetic","nervous","system","is","one","of","the","two","divisions","of","the","vertebrate","autonomic","nervous","system",".","Parasympathetic","nerves","emerge","cranially","as","pre","ganglionic","fibers","from","oculomotor",",","facial",",","glossopharyngeal","and","vagus","and","from","the","sacral","region","of","the","spinal","cord",".","Most","neurons","are","cholinergic","and","responses","are","mediated","by","muscarinic","receptors",".","The","parasympathetic","system","innervates",",","for","example",":","salivary","glands",",","thoracic","and","abdominal","viscera",",","bladder","and","genitalia","."),4043917). assertion_content_comment('tOboGo_PrematureNeuralPlateFormation',s("The","formation","of","the","neural","plate","before","the","appropriate","time","."),4222331). assertion_content_comment('tOboGo_PremeioticDNAReplication',s("The","replication","of","DNA","that","precedes","meiotic","cell","division","."),4223765). assertion_content_comment('tOboGo_PrenolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","prenols",",","isoprenoids","of","general","formula","(","H-CH2-C","(","CH3",")","=","CH-CH2-",")","n-OH",",","any","primary","monohydroxy","alcohol","whose","carbon","skeleton","consists","of","two","or","more","isoprenoid","residues","linked","head","to","tail","."),4010054). assertion_content_comment('tOboGo_PrenolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","prenols",",","isoprenoids","of","general","formula","(","H-CH2-C","(","CH3",")","=","CH-CH2-",")","n-OH",",","any","primary","monohydroxy","alcohol","whose","carbon","skeleton","consists","of","two","or","more","isoprenoid","residues","linked","head","to","tail","."),4298604). assertion_content_comment('tOboGo_PrenolKinaseActivity',s("Catalysis","of","the","reaction",":","prenol","+","nucleoside","triphosphate","=","prenyl","phosphate","+","nucleoside","diphosphate","activity","."),4192147). assertion_content_comment('tOboGo_PrenolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","prenols",",","isoprenoids","of","general","formula","(","H-CH2-C","(","CH3",")","=","CH-CH2-",")","n-OH",",","any","primary","monohydroxy","alcohol","whose","carbon","skeleton","consists","of","two","or","more","isoprenoid","residues","linked","head","to","tail","."),4010024). assertion_content_comment('tOboGo_PrenylatedProteinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","prenylated","proteins","."),4312130). assertion_content_comment('tOboGo_PrenylatedProteinTyrosinePhosphataseActivity',s("Catalysis","of","the","reaction",":","prenylated-protein","tyrosine","phosphate","+","H2O","=","prenylated-protein","tyrosine","+","phosphate","."),4200938). assertion_content_comment('tOboGo_PrenylcysteineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","prenylcysteine",",","3-methyl-2-buten-1-yl-cysteine",",","a","derivative","of","the","amino","acid","cysteine","formed","by","the","covalent","addition","of","a","prenyl","residue","."),4349552). assertion_content_comment('tOboGo_PrenylcysteineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","prenylcysteine",",","3-methyl-2-buten-1-yl-cysteine",",","a","derivative","of","the","amino","acid","cysteine","formed","by","the","covalent","addition","of","a","prenyl","residue","."),4312117). assertion_content_comment('tOboGo_PrenylcysteineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","prenylcysteine",",","3-methyl-2-buten-1-yl-cysteine",",","a","derivative","of","the","amino","acid","cysteine","formed","by","the","covalent","addition","of","a","prenyl","residue","."),4312105). assertion_content_comment('tOboGo_PrenylcysteineMethylesteraseActivity',s("Catalysis","of","the","reaction",":","protein","C-terminal","S-farnesyl-L-cysteine","methyl","ester","+","H2O","=","protein","C-terminal","S-farnesyl-L-cysteine","+","methanol","+","H","+"),4335099). assertion_content_comment('tOboGo_PrenylcysteineOxidaseActivity',s("Catalysis","of","the","reaction",":","S-prenyl-L-cysteine","+","O2","+","H2O","=","a","prenal","+","L-cysteine","+","H2O2","."),4383272). assertion_content_comment('tOboGo_PrenylProteinSpecificEndopeptidaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4255400). assertion_content_comment('tOboGo_PrenyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","prenyl","group","from","one","compound","(","donor",")","to","another","(","acceptor",")"),4183556). assertion_content_comment('tOboGo_PrephenateDehydrataseActivity',s("Catalysis","of","the","reaction",":","prephenate","=","phenylpyruvate","+","H2O","+","CO2","."),4202453). assertion_content_comment('tOboGo_PrephenateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","(","+",")","+","prephenate","=","(","4-hydroxyphenyl",")","pyruvate","+","CO","(","2",")","+","NADH","."),4247973). assertion_content_comment('tOboGo_PrephenateDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","prephenate","=","(","4-hydroxyphenyl",")","pyruvate","+","CO","(","2",")","+","NADPH","."),4202465). assertion_content_comment('tOboGo_PrepilinPeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","a","Gly-Phe","bond","to","release","an","N-terminal",",","basic","peptide","of","5-8","residues","from","type","IV","prepilin",",","and","then","N-methylates","the","new","N-terminal","amino","group",",","the","methyl","donor","being","S-adenosyl-L-methionine","."),4247963). assertion_content_comment('tOboGo_PrepilinPeptidaseComplex',s("OBSOLETE",".","An","enzyme","complex","that","catalyzes","the","cleavage","of","a","Gly-Phe","bond","to","release","an","N-terminal",",","basic","peptide","of","5-8","residues","from","type","IV","prepilin",",","and","then","N-methylates","the","new","N-terminal","amino","group","."),4260125). assertion_content_comment('tOboGo_PreprophaseBandAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","preprophase","band",",","a","dense","band","of","microtubules","that","marks","the","position","in","the","cell","where","cytokinesis","will","occur","in","cells","that","perform","cytokinesis","by","cell","plate","formation","."),3978700). assertion_content_comment('tOboGo_PreprophaseBand',s("A","dense","band","of","microtubules",",","1-3","pm","wide",",","that","appears","just","beneath","the","cell","membrane","before","the","start","of","cell","division","in","the","cells","of","higher","plants",".","It","precedes","the","onset","of","prophase","and","then","disappears","as","mitosis","begins",",","yet","it","somehow","determines","the","plane","of","orientation","of","the","new","cell","plate","forming","in","late","telophase","and","marks","the","zone","of","the","parental","cell","wall","where","fusion","with","the","growing","cell","plate","ultimately","occurs","."),4022920). assertion_content_comment('tOboGo_PreproteinBinding',s("Interacting","selectively","and","non-covalently","with","a","preprotein",",","the","unprocessed","form","of","a","protein","destined","to","undergo","co-","or","post-translational","processing","."),4177358). assertion_content_comment('tOboGo_PrepulseInhibition',s("The","process","in","which","a","startle","magnitude","is","reduced","when","the","startling","stimulus","is","preceded","by","a","low-intensity","prepulse","."),4108048). assertion_content_comment('tOboGo_PrepupalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","prepupa","over","time",",","from","its","formation","to","the","mature","structure",".","The","prepupal","stage","is","a","life","stage","interposed","between","the","larval","and","the","pupal","stages","in","insects","that","undergo","a","complete","metamorphosis",".","The","start","of","the","pre-pupal","stage","is","marked","by","pupariation",",","and","the","end","is","marked","by","pupation","."),4072925). assertion_content_comment('tOboGo_PreribosomeLargeSubunitPrecursor',s("A","preribosomal","complex","consisting","of","27SA",",","27SB",",","and/or","7S","pre-rRNA",",","5S","rRNA",",","ribosomal","proteins","including","late-associating","large","subunit","proteins",",","and","associated","proteins",";","a","precursor","of","the","eukaryotic","cytoplasmic","large","ribosomal","subunit","."),4051877). assertion_content_comment('tOboGo_Preribosome',s("Any","complex","of","pre-rRNAs",",","ribosomal","proteins",",","and","associated","proteins","formed","during","ribosome","biogenesis","."),4051875). assertion_content_comment('tOboGo_PreribosomeSmallSubunitPrecursor',s("A","preribosomal","complex","consisting","of","20S","pre-rRNA",",","ribosomal","proteins","including","late-associating","small","subunit","proteins",",","and","associated","proteins",";","a","precursor","of","the","eukaryotic","cytoplasmic","small","ribosomal","subunit","."),4051960). assertion_content_comment('tOboGo_Prespliceosome',s("A","spliceosomal","complex","that","is","formed","by","association","of","the","5","'","splice","site","and","the","branch","point","sequence","with","specific","snRNPs",".","The","prespliceosome","includes","many","proteins","in","addition","to","those","found","in","the","bound","snRNPs",".","Commitment","to","a","given","pair","of","5","'","and","3","'","splice","sites","occurs","at","the","time","of","prespliceosome","formation","."),4167643). assertion_content_comment('tOboGo_PressureNatriuresis',s("The","process","in","which","the","volume","of","blood","increases","renal","pressure","and","thereby","results","in","both","an","increase","in","urine","volume","(","diuresis",")","and","an","increase","in","the","amount","of","sodium","excreted","in","the","urine","(","natriuresis",")"),4193856). assertion_content_comment('tOboGo_PresynapticActiveZoneMembrane',s("The","membrane","portion","of","the","presynaptic","active","zone",";","it","is","the","site","where","docking","and","fusion","of","synaptic","vesicles","occurs","for","the","release","of","neurotransmitters","."),4104931). assertion_content_comment('tOboGo_PresynapticActiveZone',s("A","specialized","region","of","the","plasma","membrane","and","cell","cortex","of","a","presynaptic","neuron",";","encompasses","a","region","of","the","plasma","membrane","where","synaptic","vesicles","dock","and","fuse",",","synaptic","vesicles",",","and","a","specialized","cortical","cytoskeletal","matrix","."),4104910). assertion_content_comment('tOboGo_PresynapticCytoskeletalMatrixAssembledAtActiveZones',s("The","specialized","cytoskeletal","matrix","assembled","at","the","active","zones","of","the","presynaptic","nerve","terminal",".","The","cytoskeletal","matrix","is","a","proteinaceous","structure","involved","in","organizing","synaptic","events","such","as","immobilisation","or","translocation","of","synaptic","vesicles",",","and","assembling","active","zone","components",".","The","cytomatrix","protein","exclusively","assembled","at","active","zones",",","is","thought","to","form","a","molecular","scaffold","that","organizes","neurotransmitter","release","sites","."),4104946). assertion_content_comment('tOboGo_PresynapticMembrane',s("A","specialized","area","of","membrane","of","the","axon","terminal","that","faces","the","plasma","membrane","of","the","neuron","or","muscle","fiber","with","which","the","axon","terminal","establishes","a","synaptic","junction",";","many","synaptic","junctions","exhibit","structural","presynaptic","characteristics",",","such","as","conical",",","electron-dense","internal","protrusions",",","that","distinguish","it","from","the","remainder","of","the","axon","plasma","membrane","."),4104928). assertion_content_comment('tOboGo_PreventionOfPolyspermy',s("The","negative","regulation","of","fertilization","process","that","takes","place","as","part","of","egg","activation",",","ensuring","that","only","a","single","sperm","fertilizes","the","egg","."),4117829). assertion_content_comment('tOboGo_PrimaryActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","solute","from","one","side","of","the","membrane","to","the","other",",","up","the","solute","'","s","concentration","gradient",",","by","binding","the","solute","and","undergoing","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","powered","by","a","primary","energy","source",".","Primary","energy","sources","known","to","be","coupled","to","transport","are","chemical",",","electrical","and","solar","sources","."),4168922). assertion_content_comment('tOboGo_PrimaryAlcoholBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","primary","alcohols",".","A","primary","alcohol","is","any","alcohol","in","which","a","hydroxy","group",",","-OH",",","is","attached","to","a","saturated","carbon","atom","which","has","either","three","hydrogen","atoms","attached","to","it","or","only","one","other","carbon","atom","and","two","hydrogen","atoms","attached","to","it","."),4096262). assertion_content_comment('tOboGo_PrimaryAlcoholCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","primary","alcohols",".","A","primary","alcohol","is","any","alcohol","in","which","a","hydroxy","group",",","-OH",",","is","attached","to","a","saturated","carbon","atom","which","has","either","three","hydrogen","atoms","attached","to","it","or","only","one","other","carbon","atom","and","two","hydrogen","atoms","attached","to","it","."),4224845). assertion_content_comment('tOboGo_PrimaryAlcoholMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","primary","alcohols",".","A","primary","alcohol","is","any","alcohol","in","which","a","hydroxy","group",",","-OH",",","is","attached","to","a","saturated","carbon","atom","which","has","either","three","hydrogen","atoms","attached","to","it","or","only","one","other","carbon","atom","and","two","hydrogen","atoms","attached","to","it","."),4096214). assertion_content_comment('tOboGo_PrimaryAmineOxidaseActivity',s("Catalysis","of","the","reaction",":","a","primary","amine","+","H2O","+","O2","=","an","aldehyde","+","NH3","+","hydrogen","peroxide","."),4246543). assertion_content_comment('tOboGo_PrimaryBranchingOpenTrachealSystem',s("Formation","of","primary","branches","in","the","open","tracheal","system",".","These","form","from","small","groups","of","cells","that","migrate","out","at","specific","positions",",","organizing","into","tubes","as","they","migrate",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4234675). assertion_content_comment('tOboGo_PrimaryCellSeptumBiogenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","primary","cell","septum","following","nuclear","division","."),4056877). assertion_content_comment('tOboGo_PrimaryCellSeptumDisassembly',s("Dissolution","of","the","primary","septum","during","cell","separation","."),4061203). assertion_content_comment('tOboGo_PrimaryCellSeptum',s("A","cell","septum","that","forms","following","nuclear","division","."),4363195). assertion_content_comment('tOboGo_PrimaryCellWallBiogenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","cellulose","and","pectin-containing","cell","walls","that","form","adjacent","to","the","middle","lamella","following","cell","division","and","during","cell","expansion",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),4262603). assertion_content_comment('tOboGo_PrimaryCellWall',s("A","plant","cell","wall","that","is","still","able","to","expand",",","permitting","cell","growth",".","Primary","cell","walls","contain","more","pectin","than","secondary","walls","and","no","lignin","is","present","."),4023087). assertion_content_comment('tOboGo_PrimaryChargeSeparationInPhotosystemII',s("Energized","reaction-center","P680","chlorophylls","on","photosystem","II","donate","an","electron","to","a","loosely","bound","acceptor","molecule",",","the","quinone","Q",",","on","the","stromal","surface","of","the","thylakoid","membrane",".","The","result","is","charge","separation",";","a","negative","charge","on","the","stromal","side","of","the","thylakoid","membrane","and","a","positive","charge","on","the","luminal","side","."),4262804). assertion_content_comment('tOboGo_PrimaryChargeSeparationInPhotosystemI',s("Energized","reaction-center","P700","chlorophylls","on","photosystem","I","donate","an","electron","to","a","loosely","bound","Quinone","acceptor","molecule","X",",","on","the","stromal","surface","of","the","thylakoid","membrane",".","The","result","is","charge","separation",";","a","negative","charge","on","the","stromal","side","of","the","thylakoid","membrane","and","a","positive","charge","on","the","luminal","side","."),4262813). assertion_content_comment('tOboGo_PrimaryChargeSeparation',s("In","the","photosynthetic","reaction","centers",",","primary","charge","separation","is","initiated","by","the","excitation","of","a","molecule","followed","by","the","transfer","of","an","electron","to","an","electron","acceptor","molecule","following","energy","transfer","from","light","harvesting","complexes","."),4022407). assertion_content_comment('tOboGo_PrimaryCilium',s("A","cilium","found","on","many","different","cell","types","that","is","typically","present","in","a","single","copy","per","cell",".","A","primary","cilium","may","have","a","variable","array","of","axonemal","microtubules","and","may","or","may","not","contain","molecular","motors","."),4077625). assertion_content_comment('tOboGo_PrimaryEndospermNucleus',s("Nucleus","resulting","from","the","fusion","of","the","male","gamete","and","two","polar","nuclei","in","the","central","cell","of","the","embryo","sac","."),4334561). assertion_content_comment('tOboGo_PrimaryFollicleStage',s("The","stage","in","oogenesis","when","a","single","layer","of","cuboidal","follicle","cells","surrounds","the","oocyte",".","The","oocyte","nucleus","is","large","."),4096357). assertion_content_comment('tOboGo_PrimaryHeartFieldSpecification',s("The","process","that","results","in","the","delineation","of","a","specific","region","of","the","lateral","mesoderm","into","the","area","which","will","form","the","primary","beating","heart","tube","."),4193827). assertion_content_comment('tOboGo_PrimaryLeafletMorphogenesis',s("The","process","in","which","the","primary","leaflet","attains","its","shape",".","A","primary","leaflet","is","a","leaflet","that","develops","directly","from","the","rachis","."),4161025). assertion_content_comment('tOboGo_PrimaryLungBudFormation',s("The","morphogenetic","process","in","which","the","foregut","region","specified","to","become","the","lung","forms","the","initial","left","and","right","buds","."),4116631). assertion_content_comment('tOboGo_PrimaryLysosome',s("A","lysosome","before","it","has","fused","with","a","vesicle","or","vacuole","."),4082342). assertion_content_comment('tOboGo_PrimaryMeristemTissueDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","primary","meristem","over","time",",","from","formation","to","the","mature","structure",",","as","it","occurs","during","plant","embryogenesis",".","The","primary","meristem","tissue","is","the","protoderm",",","ground","meristem","and","procambium","."),4329631). assertion_content_comment('tOboGo_PrimaryMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","those","compounds","which","are","formed","as","a","part","of","the","normal","anabolic","and","catabolic","processes",".","These","processes","take","place","in","most",",","if","not","all",",","cells","of","the","organism","."),3969023). assertion_content_comment('tOboGo_PrimaryMicroRNAProcessing',s("Any","process","involved","in","the","conversion","of","a","primary","microRNA","transcript","into","a","pre-microRNA","molecule","."),4061051). assertion_content_comment('tOboGo_PrimaryNeuralTubeFormation',s("The","formation","of","the","neural","tube","from","an","epithelial","cell","sheet","(","the","neuroepithelium","or","neural","plate",")","In","primary","neurulation",",","the","cells","surrounding","the","neural","plate","direct","the","neural","plate","cells","to","proliferate",",","invaginate",",","and","pinch","off","from","the","surface","to","form","a","hollow","epithelial","tube",".","Primary","neurulation","is","the","typical","mechanism","of","formation","of","the","anterior","neural","tube","."),3987164). assertion_content_comment('tOboGo_PrimaryOocyteStage',s("The","stage","in","oogenesis","when","the","oocyte","has","a","nucleus","slightly","larger","than","those","of","the","adjacent","cells","and","is","surrounded","by","a","layer","of","loose","squamous","epithelial","cells","."),4385183). assertion_content_comment('tOboGo_PrimaryOvarianFollicleGrowthInvolvedInDoubleLayerFollicleStage',s("Increase","in","size","of","primary","follicles","including","oocyte","growth","and","granulosa","and/or","theca","cell","proliferation","until","more","than","one","layer","of","granulosa","cells","is","present","(","preantral","follicle",")",",","as","part","of","the","double","layer","follicle","stage","of","oogenesis","."),4096347). assertion_content_comment('tOboGo_PrimaryOvarianFollicleGrowthInvolvedInPrimaryFollicleStage',s("Increase","in","size","of","primary","follicles","including","oocyte","growth","and","granulosa","and/or","theca","cell","proliferation","until","more","than","one","layer","of","granulosa","cells","is","present","(","preantral","follicle",")","as","part","of","the","primary","follicle","stage","of","oogenesis","."),4096368). assertion_content_comment('tOboGo_PrimaryOvarianFollicleGrowth',s("Increase","in","size","of","primary","follicles","including","oocyte","growth","and","granulosa","and/or","theca","cell","proliferation","until","more","than","one","layer","of","granulosa","cells","is","present","(","preantral","follicle",")"),3981877). assertion_content_comment('tOboGo_PrimaryPlasmodesma',s("A","plasmodesma","that","consists","of","a","simple",",","single","channel",";","found","predominantly","in","young","tissue","and","formed","as","a","function","of","cell","plate","formation","during","cytokinesis","."),4261551). assertion_content_comment('tOboGo_PrimaryProstaticBudElongation',s("The","increase","in","size","of","the","prostatic","bud","as","it","forms","."),4116740). assertion_content_comment('tOboGo_PrimaryRootDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","primary","root","over","time",",","from","its","formation","to","the","mature","structure",".","The","primary","root","develops","directly","from","the","embryonic","radicle","."),4182258). assertion_content_comment('tOboGo_PrimarySexDeterminationSoma',s("The","transmission","of","information","about","sexual","status","from","the","initial",",","general",",","determination","to","signals","specific","to","the","soma","."),4018610). assertion_content_comment('tOboGo_PrimarySexDetermination',s("The","sex","determination","process","that","results","in","the","initial","specification","of","sexual","status","of","an","individual","organism","."),4015945). assertion_content_comment('tOboGo_PrimaryShootApicalMeristemSpecification',s("The","specification","of","the","meristem","which","will","give","rise","to","all","post-embryonic","above-ground","structures","of","the","plant","as","well","as","the","non-root","below-ground","structures",",","such","as","rhizomes","and","tubers","."),4032505). assertion_content_comment('tOboGo_PrimarySpermatocyteGrowth',s("The","phase","of","growth","and","gene","expression","that","male","germ","cells","undergo","as","they","enter","the","spermatocyte","stage",".","The","cells","grow","in","volume","and","transcribe","most","of","the","gene","products","needed","for","the","morphological","events","that","follow","meiosis","."),4016861). assertion_content_comment('tOboGo_PrimaryUretericBudGrowth',s("The","process","in","which","the","primary","ureteric","bud","grows","along","its","axis","dorsally","toward","the","metanephric","blastema","."),4160969). assertion_content_comment('tOboGo_PrimingOfCellularResponseToStress',s("The","process","that","enables","cells","to","respond","in","a","more","rapid","and","robust","manner","than","nonprimed","cells","to","much","lower","levels","of","a","stimulus","indicating","the","organism","is","under","stress","."),4147758). assertion_content_comment('tOboGo_PrimitiveErythrocyteDifferentiation',s("Erythrocyte","differentiation","which","occurs","as","part","of","the","process","of","primitive","hemopoiesis","."),4024378). assertion_content_comment('tOboGo_PrimitiveHemopoiesis',s("A","first","transient","wave","of","blood","cell","production","that",",","in","vertebrates",",","gives","rise","to","erythrocytes","(","red","blood","cells",")","and","myeloid","cells","."),4024373). assertion_content_comment('tOboGo_PrimitiveStreakFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","primitive","streak","from","unspecified","parts",".","The","primitive","streak","is","a","ridge","of","cells","running","along","the","midline","of","the","embryo","where","the","mesoderm","ingresses",".","It","defines","the","anterior-posterior","axis","."),4149605). assertion_content_comment('tOboGo_PrincipalSensoryNucleusOfTrigeminalNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pontine","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042798). assertion_content_comment('tOboGo_ProanthocyanidinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","proanthocyanidin","."),4139502). assertion_content_comment('tOboGo_ProboscisDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","proboscis","over","time",",","from","its","formation","to","the","mature","structure","."),4025214). assertion_content_comment('tOboGo_ProboscisExtensionReflex',s("The","extension",",","through","direct","muscle","actions",",","of","the","proboscis","(","the","trunk-like","extension","of","the","mouthparts","on","the","adult","external","head",")","in","response","to","a","sugar","stimulus","."),4235097). assertion_content_comment('tOboGo_ProboscisMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","proboscis","are","generated","and","organized",".","The","proboscis","is","the","trunk-like","extension","of","the","mouthparts","on","the","adult","head","."),4025216). assertion_content_comment('tOboGo_ProcambiumHistogenesis',s("The","formation","of","the","primary","meristem","or","meristematic","tissue","that","gives","rise","to","the","primary","vascular","tissue","."),4329662). assertion_content_comment('tOboGo_ProcessesDownstreamOfSexDeterminationSignal',s("The","sex","determination","processes","that","take","place","after","the","initial","transmission","of","the","sexual","phenotype","to","specific","information","pathways","."),4015925). assertion_content_comment('tOboGo_ProclavaminateAmidinohydrolaseActivity',s("Catalysis","of","the","reaction",":","amidinoproclavaminate","+","H","(","2",")","O","=","proclavaminate","+","urea","."),4345055). assertion_content_comment('tOboGo_ProcollagenGalactosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-galactose","+","procollagen","5-hydroxy-L-lysine","=","UDP","+","procollagen","5-","(","D-galactosyloxy",")","-L-lysine","."),4263280). assertion_content_comment('tOboGo_ProcollagenGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","5-","(","D-galactosyloxy",")","-L-lysine-procollagen","=","UDP","+","1",",","2-D-glucosyl-5-D-","(","galactosyloxy",")","-L-lysine-procollagen","."),4343255). assertion_content_comment('tOboGo_ProctolinReceptorActivity',s("Combining","with","the","neuropeptide","proctolin",",","to","initiate","a","change","in","cell","activity","."),4382639). assertion_content_comment('tOboGo_ProctolinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","proctolin","receptor","."),4170592). assertion_content_comment('tOboGo_ProductionOfLsiRNAInvolvedInRNAInterference',s("Cleavage","of","double-stranded","RNA","to","form","lsiRNA","(","long","small","interfering","RNA",")",",","a","class","of","siRNAs","30","to","40","nt","in","length",".","lsiRNAs","are","induced","by","pathogen","infection","or","under","specific","growth","conditions","."),4028171). assertion_content_comment('tOboGo_ProductionOfMiRNAsInvolvedInGeneSilencingByMiRNA',s("Cleavage","of","stem-loop","RNA","precursors","into","microRNAs","(","miRNAs",")",",","a","class","of","small","RNAs","that","primarily","silence","genes","by","blocking","the","translation","of","mRNA","transcripts","into","protein","."),4061030). assertion_content_comment('tOboGo_ProductionOfMolecularMediatorInvolvedInInflammatoryResponse',s("The","synthesis","or","release","of","any","molecular","mediator","of","the","inflammatory","response","following","an","inflammatory","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),3993523). assertion_content_comment('tOboGo_ProductionOfMolecularMediatorOfImmuneResponse',s("The","synthesis","or","release","of","any","molecular","mediator","of","the","immune","response",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),3993146). assertion_content_comment('tOboGo_ProductionOfSiRNAInvolvedInChromatinSilencingBySmallRNA',s("Cleavage","of","double-stranded","RNA","to","form","small","interfering","RNA","molecules","(","siRNAs",")","of","21-23","nucleotides",",","in","the","context","of","chromatin","silencing","by","small","RNA","."),4131906). assertion_content_comment('tOboGo_ProductionOfSiRNAInvolvedInRNAInterference',s("Cleavage","of","double-stranded","RNA","to","form","small","interfering","RNA","molecules","(","siRNAs",")","of","21-23","nucleotides",",","in","the","context","of","RNA","interference","."),4046290). assertion_content_comment('tOboGo_ProductionOfSmallRNAInvolvedInGeneSilencingByRNA',s("The","process","in","which","a","double-stranded","RNA","precursor","is","processed","into","short","(","20-30","nt",")","fragments",".","RNA","cleavage","is","catalyzed","by","a","Dicer","endonuclease","."),4028166). assertion_content_comment('tOboGo_ProepicardiumCellMigrationInvolvedInPericardiumMorphogenesis',s("The","coordinated","movement","of","a","mesenchymal","proepicardial","cell","to","the","surface","of","the","developing","heart","."),4005979). assertion_content_comment('tOboGo_ProepicardiumDevelopment',s("The","progression","of","the","proepicardium","from","its","formation","to","the","mature","structure",".","The","proepicardium","is","an","outpouching","of","the","septum","transversum","."),4006258). assertion_content_comment('tOboGo_Proestrus',s("The","estrous","cycle","phase","in","which","there","is","heightened","follicular","activity","."),4160116). assertion_content_comment('tOboGo_ProfilinBinding',s("Interacting","selectively","and","non-covalently","with","profilin",",","an","actin-binding","protein","that","forms","a","complex","with","G-actin","and","prevents","it","from","polymerizing","to","form","F-actin","."),4218726). assertion_content_comment('tOboGo_ProgesteroneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","progesterone",",","a","steroid","hormone","produced","in","the","ovary","which","prepares","and","maintains","the","uterus","for","pregnancy",".","Also","found","in","plants","."),4133619). assertion_content_comment('tOboGo_ProgesteroneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","progesterone",",","a","steroid","hormone","produced","in","the","ovary","which","prepares","and","maintains","the","uterus","for","pregnancy",".","Also","found","in","plants","."),4229639). assertion_content_comment('tOboGo_ProgesteroneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","progesterone",",","a","steroid","hormone","produced","in","the","ovary","which","prepares","and","maintains","the","uterus","for","pregnancy",".","Also","found","in","plants","."),4133616). assertion_content_comment('tOboGo_ProgesteroneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","AH","(","2",")","+","O","(","2",")","+","progesterone","=","A","+","H","(","2",")","O","+","testosterone","acetate","."),4263298). assertion_content_comment('tOboGo_ProgesteroneReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","progesterone","receptor","."),4347897). assertion_content_comment('tOboGo_ProgesteroneReceptorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","a","progesterone","binding","to","its","receptor","."),4274713). assertion_content_comment('tOboGo_ProgesteroneSecretion',s("The","regulated","release","of","progesterone",",","a","steroid","hormone",",","by","the","corpus","luteum","of","the","ovary","and","by","the","placenta","."),4078379). assertion_content_comment('tOboGo_ProgrammedCellDeath',s("Cell","death","resulting","from","activation","of","endogenous","cellular","processes","."),3981308). assertion_content_comment('tOboGo_ProgrammedDNAElimination',s("The","DNA","metabolic","process","in","which","micronuclear-limited","sequences",",","internal","eliminated","sequences","(","IES",")","and","breakage","eliminated","sequences","(","BES",")","are","removed","from","the","developing","macronucleus","(","anlage",")","of","a","ciliate","."),4060986). assertion_content_comment('tOboGo_ProgressionOfMorphogeneticFurrowInvolvedInCompoundEyeMorphogenesis',s("The","morphogenetic","furrow","is","a","dorsoventral","indentation","which","sweeps","anteriorly","across","the","eye","disc",".","Ommatidia","begin","to","form","along","the","furrow",",","resulting","in","a","graded","series","of","ommatidial","development","across","the","anterior/posterior","axis","of","the","disc","."),4017793). assertion_content_comment('tOboGo_ProgressionOfNeuralTubeClosure',s("The","process","in","which","the","neural","folds","are","fused","extending","from","the","initial","closure","points","."),4046435). assertion_content_comment('tOboGo_ProgressiveAlterationOfChromatinInvolvedInCellAging',s("The","chromatin","modification","process","that","occurs","during","the","lifespan","of","the","cell","that","results","in","changes","in","chromatin","structure",".","Such","changes","may","lead","to","gene","dysregulation","and","ultimately","to","a","loss","in","cell","homeostasis",",","bringing","about","an","aging","phenotype","."),3979752). assertion_content_comment('tOboGo_ProgressiveAlterationOfChromatinInvolvedInChronologicalCellAging',s("A","process","that","results","in","changes","in","chromatin","structure","contributing","to","chronological","cell","aging",",","occurring","in","non-dividing","cells","."),3979775). assertion_content_comment('tOboGo_ProgressiveAlterationOfChromatinInvolvedInReplicativeCellAging',s("A","process","that","results","in","changes","in","chromatin","structure","contributing","to","replicative","cell","aging","."),3979867). assertion_content_comment('tOboGo_ProlactinReceptorActivity',s("Combining","with","prolactin","to","initiate","a","change","in","cell","activity","."),4198449). assertion_content_comment('tOboGo_ProlactinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","prolactin","receptor","."),4214389). assertion_content_comment('tOboGo_ProlactinSecretingCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","prolactin","secreting","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","prolactin","secreting","cell","is","an","acidophilic","cell","of","the","anterior","pituitary","that","produces","prolactin","."),4107989). assertion_content_comment('tOboGo_ProlactinSecretingCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","structural","and/or","functional","features","of","a","prolactin","secreting","cell",".","A","prolactin","secreting","cell","is","an","acidophilic","cell","of","the","anterior","pituitary","that","produces","prolactin","."),4107971). assertion_content_comment('tOboGo_ProlactinSecretion',s("The","regulated","release","of","prolactin",",","a","peptide","hormone","that","stimulates","lactation",",","from","secretory","granules","in","the","anterior","pituitary","."),4176089). assertion_content_comment('tOboGo_ProliferatingCellNuclearAntigen',s("OBSOLETE",".","A","nuclear","protein","that","associates","as","a","trimer","and","then","interacts","with","delta","DNA","polymerase","and","epsilon","DNA","polymerase",",","acting","as","an","auxiliary","factor","for","DNA","replication","and","DNA","repair","."),4190442). assertion_content_comment('tOboGo_ProlineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","proline","(","pyrrolidine-2-carboxylic","acid",")",",","a","chiral",",","cyclic",",","nonessential","alpha-amino","acid","found","in","peptide","linkage","in","proteins","."),4222208). assertion_content_comment('tOboGo_ProlineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","proline","(","pyrrolidine-2-carboxylic","acid",")",",","a","chiral",",","cyclic",",","nonessential","alpha-amino","acid","found","in","peptide","linkage","in","proteins","."),4232163). assertion_content_comment('tOboGo_ProlineCatabolicProcessToGlutamate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","proline","into","other","compounds",",","including","glutamate","."),4334378). assertion_content_comment('tOboGo_ProlineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-proline","+","acceptor","=","(","S",")","-1-pyrroline-5-carboxylate","+","reduced","acceptor","."),4203222). assertion_content_comment('tOboGo_ProlineGlycineBetaine_HydrogenSodiumSymporterActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","(","proline",",","glycine","or","betaine",")","(","out",")","+","(","H","+","or","Na","+",")","(","out",")","=","(","proline",",","glycine","or","betaine",")","(","in",")","+","(","H","+","or","Na","+",")","(","in",")"),4293243). assertion_content_comment('tOboGo_ProlineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","proline","(","pyrrolidine-2-carboxylic","acid",")",",","a","chiral",",","cyclic",",","nonessential","alpha-amino","acid","found","in","peptide","linkage","in","proteins","."),4140715). assertion_content_comment('tOboGo_ProlineOxidaseActivity',s("Catalysis","of","the","reaction",":","L-proline","+","O2","+","H2O","=","L-delta1-pyrroline-5-carboxylate","+","H2O2","."),4285354). assertion_content_comment('tOboGo_ProlineRacemaseActivity',s("Catalysis","of","the","reaction",":","L-proline","=","D-proline","."),4285067). assertion_content_comment('tOboGo_ProlineSalvage',s("Any","process","which","produces","the","amino","acid","proline","from","derivatives","of","it",",","without","de","novo","synthesis","."),4240890). assertion_content_comment('tOboGo_Proline_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","proline","(","out",")","+","Na","+","(","out",")","=","proline","(","in",")","+","Na","+","(","in",")"),4215870). assertion_content_comment('tOboGo_ProlineTransmembraneTransport',s("The","directed","movement","of","proline",",","pyrrolidine-2-carboxylic","acid",",","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4379094). assertion_content_comment('tOboGo_ProlineTransport',s("The","directed","movement","of","proline",",","pyrrolidine-2-carboxylic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4132044). assertion_content_comment('tOboGo_ProlylAminopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","a","N-terminal","proline","from","a","peptide","."),4301609). assertion_content_comment('tOboGo_ProlylOligopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","Pro-Xaa","&","gt",";","Ala-Xaa","in","oligopeptides","."),4209511). assertion_content_comment('tOboGo_Prominosome',s("An","extracellular","membrane-bounded","vesicle","that","contains","prominin","proteins","(","in","mouse","Prom1/CD33","or","Prom2",")","and","are","found","in","body","fluids","including","ventricular","fluid",",","saliva",",","urine","and","seminal","fluid",".","In","the","ventricular","fluid","of","the","developing","mouse","brain","two","major","classes","of","these","particles","have","been","observed","(","P2","particles","of","500-1000","nm","and","P4","particles","of","50-80","nm",")","which","likely","originate","from","microvilli",",","primary","cilia","and/or","the","midbody","of","neuroepithelial","cells",".","The","physiological","role","is","not","known","."),4168226). assertion_content_comment('tOboGo_PromoterBinding',s("Interacting","selectively","and","non-covalently","with","the","regulatory","region","composed","of","the","transcription","start","site","and","binding","sites","for","transcription","factor","complexes","of","the","basal","transcription","machinery","."),4170909). assertion_content_comment('tOboGo_PromoterClearanceFromRNAPolymeraseIIIPromoter',s("Any","process","involved","in","the","transition","from","the","initiation","to","the","elongation","phases","of","transcription","by","RNA","polymerase","III",",","generally","including","a","conformational","change","from","the","initiation","conformation","to","the","elongation","conformation",".","Promoter","clearance","often","involves","breaking","contact","with","transcription","factors","involved","only","in","the","initiation","phase","."),3980410). assertion_content_comment('tOboGo_PromoterClearanceFromRNAPolymeraseIIPromoter',s("Any","process","involved","in","the","transition","from","the","initiation","to","the","elongation","phases","of","transcription","by","RNA","polymerase","II",",","generally","including","a","conformational","change","from","the","initiation","conformation","to","the","elongation","conformation",".","Promoter","clearance","often","involves","breaking","contact","with","transcription","factors","involved","only","in","the","initiation","phase","and","making","contacts","with","elongation","specific","factors","."),3980420). assertion_content_comment('tOboGo_PronephricDistalTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pronephric","distal","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","A","pronephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","pronephros","."),4058958). assertion_content_comment('tOboGo_PronephricDistalTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","pronephric","nephron","distal","tubule","are","generated","and","organized",".","A","pronephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","pronephros","."),4058960). assertion_content_comment('tOboGo_PronephricDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pronephric","duct","over","time",",","from","its","formation","to","the","mature","structure",".","The","pronephric","duct","collects","the","filtrate","from","the","pronephric","tubules","and","opens","to","the","exterior","of","the","pronephric","kidney","."),4058799). assertion_content_comment('tOboGo_PronephricDuctMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","pronephric","duct","are","generated","and","organized",".","The","pronephric","duct","collects","the","filtrate","from","the","pronephric","tubules","and","opens","to","the","exterior","of","the","kidney","."),4058813). assertion_content_comment('tOboGo_PronephricFieldSpecification',s("The","process","in","which","regions","of","the","embryo","are","delineated","into","the","area","in","which","the","pronephric","kidney","will","develop","."),4059218). assertion_content_comment('tOboGo_PronephricGlomerulusDevelopment',s("The","progression","of","the","glomerulus","of","the","pronephric","kidney","over","time","from","its","initial","formation","until","its","mature","state",".","The","pronephric","glomerulus","is","part","of","the","pronephric","nephron","and","is","restricted","to","one","body","segment","."),4058845). assertion_content_comment('tOboGo_PronephricGlomerulusMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","pronephric","glomerulus","are","generated","and","organized",".","The","pronephric","glomerulus","is","part","of","the","pronephric","nephron","and","is","restricted","to","one","body","segment","."),4081412). assertion_content_comment('tOboGo_PronephricNephronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pronephric","nephron","over","time",",","from","its","formation","to","the","mature","structure",".","A","pronephric","nephron","is","the","functional","unit","of","the","pronephros","."),4058843). assertion_content_comment('tOboGo_PronephricNephronMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","pronephric","nephron","are","generated","and","organized",".","A","pronephric","nephron","is","the","functional","unit","of","the","pronephros","."),4058924). assertion_content_comment('tOboGo_PronephricNephronTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","pronephric","nephron","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","pronephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","pronephric","nephron","and","connects","the","filtration","unit","(","glomerulus","or","glomus",")","of","the","pronephros","to","the","pronephric","duct","."),4058865). assertion_content_comment('tOboGo_PronephricNephronTubuleEpithelialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","cells","of","the","pronephric","nephron","tubule","as","it","progresses","from","its","formation","to","the","mature","state","."),4081422). assertion_content_comment('tOboGo_PronephricNephronTubuleFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","pronephric","nephron","tubule","from","unspecified","parts",".","A","pronephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","a","nephron","in","the","pronephros","."),4059279). assertion_content_comment('tOboGo_PronephricNephronTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","pronephric","nephron","tubule","are","generated","and","organized","from","an","epithelium",".","A","pronephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","pronephric","nephron","."),4058927). assertion_content_comment('tOboGo_PronephricProximalTubuleDevelopment',s("The","progression","of","the","pronephric","proximal","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","A","pronephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","pronephros","."),4059151). assertion_content_comment('tOboGo_PronephricProximalTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","pronephric","nephron","proximal","tubule","are","generated","and","organized",".","A","pronephric","nephron","tubule","is","an","epithelial","tube","that","is","part","of","the","pronephros","."),4059153). assertion_content_comment('tOboGo_PronephricSinusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pronephric","sinus","over","time",",","from","its","formation","to","the","mature","structure",".","The","pronephric","sinus","is","an","ill-defined","capillary","network","that","lies","between","the","pronephric","tubules","."),4058886). assertion_content_comment('tOboGo_PronephrosDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pronephros","over","time",",","from","its","formation","to","the","mature","structure",".","In","mammals",",","the","pronephros","is","the","first","of","the","three","embryonic","kidneys","to","be","established","and","exists","only","transiently",".","In","lower","vertebrates","such","as","fish","and","amphibia",",","the","pronephros","is","the","fully","functional","embryonic","kidney","and","is","indispensable","for","larval","life","."),4058796). assertion_content_comment('tOboGo_PronephrosFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","pronephros",".","In","mammals",",","the","pronephros","is","the","first","of","the","three","embryonic","kidneys","to","be","established","and","exists","only","transiently",".","In","lower","vertebrates","such","as","fish","and","amphibia",",","the","pronephros","is","the","fully","functional","embryonic","kidney","and","is","indispensable","for","larval","life","."),4059276). assertion_content_comment('tOboGo_PronephrosMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","pronephros","to","attain","its","fully","functional","state",".","In","mammals",",","the","pronephros","is","the","first","of","the","three","embryonic","kidneys","to","be","established","and","exists","only","transiently",".","In","lower","vertebrates","such","as","fish","and","amphibia",",","the","pronephros","is","the","fully","functional","embryonic","kidney","and","is","indispensable","for","larval","life","."),4122685). assertion_content_comment('tOboGo_PronephrosMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","pronephros","are","generated","and","organized",".","In","mammals",",","the","pronephros","is","the","first","of","the","three","embryonic","kidneys","to","be","established","and","exists","only","transiently",".","In","lower","vertebrates","such","as","fish","and","amphibia",",","the","pronephros","is","the","fully","functional","embryonic","kidney","and","is","indispensable","for","larval","life","."),4058810). assertion_content_comment('tOboGo_PronephrosStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","pronephros",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","In","mammals",",","the","pronephros","is","the","first","of","the","three","embryonic","kidneys","to","be","established","and","exists","only","transiently",".","In","lower","vertebrates","such","as","fish","and","amphibia",",","the","pronephros","is","the","fully","functional","embryonic","kidney","and","is","indispensable","for","larval","life","."),4122642). assertion_content_comment('tOboGo_PronuclearEnvelopeSynthesis',s("Synthesis","and","ordering","of","the","envelope","of","pronuclei","."),4045290). assertion_content_comment('tOboGo_PronuclearFusion',s("The","merging","of","two","pronuclei","in","a","fertilized","egg","to","fuse","and","produce","a","single","zygotic","genome","."),4019202). assertion_content_comment('tOboGo_PronuclearMigration',s("The","directed","movement","of","the","male","and","female","pronuclei","towards","each","other","prior","to","their","fusion","."),4072745). assertion_content_comment('tOboGo_Pronucleus',s("The","nucleus","of","either","the","ovum","or","the","spermatozoon","following","fertilization",".","Thus",",","in","the","fertilized","ovum",",","there","are","two","pronuclei",",","one","originating","from","the","ovum",",","the","other","from","the","spermatozoon","that","brought","about","fertilization",";","they","approach","each","other",",","but","do","not","fuse","until","just","before","the","first","cleavage",",","when","each","pronucleus","loses","its","membrane","to","release","its","contents","."),4300196). assertion_content_comment('tOboGo_PropanediolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","propanediol",",","a","sweet",",","colorless",",","viscous",",","hygroscopic","liquid","with","the","formula","CH3-CHOH-CH2OH","."),4287365). assertion_content_comment('tOboGo_PropanediolChannelActivity',s("Catalysis","of","facilitated","diffusion","of","propanediol","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel","without","evidence","for","a","carrier-mediated","mechanism","."),4295468). assertion_content_comment('tOboGo_PropanediolDegradationPolyhedralOrganelle',s("An","organelle","found","in","bacteria","consisting","of","a","proteinaceous","coat","containing","enzymes","for","the","degradation","of","1",",","2-propanediol","whose","purpose","is","the","protection","of","the","rest","of","the","cell","from","the","toxic","propionaldehyde","product","of","the","enzyme","diol","dehydratase","."),4321608). assertion_content_comment('tOboGo_PropanediolDehydrataseActivity',s("Catalysis","of","the","reaction",":","propane-1",",","2-diol","=","H","(","2",")","O","+","propanal","."),4263221). assertion_content_comment('tOboGo_PropanediolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","propanediol",",","CH3-CHOH-CH2OH",",","a","sweet",",","colorless",",","viscous",",","hygroscopic","liquid","used","as","an","antifreeze",",","in","brake","fluid","and","as","a","humectant","in","cosmetics","and","personal","care","items","."),4287358). assertion_content_comment('tOboGo_PropanediolTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","propanediol","from","one","side","of","the","membrane","to","the","other",".","Propanediol","is","a","sweet","colorless",",","viscous",",","hygroscopic","liquid","used","as","an","antifreeze","and","in","brake","fluid",";","it","is","also","as","a","humectant","in","cosmetics","and","personal","care","items",",","although","it","can","be","absorbed","through","the","skin","with","harmful","effects","."),4295466). assertion_content_comment('tOboGo_PropanediolTransport',s("The","directed","movement","of","propanediol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Propanediol","is","a","sweet","colorless",",","viscous",",","hygroscopic","liquid","used","as","an","antifreeze","and","in","brake","fluid",";","it","is","also","as","a","humectant","in","cosmetics","and","personal","care","items",",","although","it","can","be","absorbed","through","the","skin","with","harmful","effects","."),4290991). assertion_content_comment('tOboGo_PropanoateTransport',s("The","directed","movement","of","propionate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290873). assertion_content_comment('tOboGo_ProphageIntegraseActivity',s("Catalysis","of","the","integration","of","prophage","DNA","into","a","target","DNA","molecule",",","usually","a","bacterial","chromosome","."),4247997). assertion_content_comment('tOboGo_ProphaseChromosome',s("OBSOLETE",".","A","chromosome","found","in","the","cell","during","prophase","."),4219792). assertion_content_comment('tOboGo_Prophase',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","prophase",",","the","first","stage","of","chromosome","segregation","in","the","cell","cycle",".","Canonically",",","chromosomes","condense","and","the","two","daughter","centrioles","and","their","asters","migrate","toward","the","poles","of","the","cell","."),3971179). assertion_content_comment('tOboGo_PropioinSynthaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxyhexan-3-one","=","2","propanal","."),4263253). assertion_content_comment('tOboGo_PropionateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","propionate",",","the","anion","derived","from","propionic","acid","."),4242201). assertion_content_comment('tOboGo_PropionateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","propionate",",","the","anion","derived","from","propionic","acid","."),4242216). assertion_content_comment('tOboGo_PropionateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","propanoate","=","ADP","+","propanoyl","phosphate","."),4248179). assertion_content_comment('tOboGo_PropionateMetabolicProcessMethylcitrateCycle',s("The","chemical","reactions","and","pathways","involving","propionate","that","occur","in","the","methylcitrate","cycle","."),4244821). assertion_content_comment('tOboGo_PropionateMetabolicProcessMethylmalonylPathway',s("The","chemical","reactions","and","pathways","involving","propionate","that","occur","in","the","methylmalonyl","pathway","."),4244832). assertion_content_comment('tOboGo_PropionateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","propionate",",","the","anion","derived","from","propionic","(","propanoic",")","acid",",","a","carboxylic","acid","important","in","the","energy","metabolism","of","ruminants","."),4242195). assertion_content_comment('tOboGo_PropionateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","propionate","from","one","side","of","the","membrane","to","the","other",".","Propionate","(","or","propanoate",")","is","the","organic","acid","CH3-CH2-COOH","."),4293301). assertion_content_comment('tOboGo_ProplastidNucleoid',s("The","region","of","a","proplastid","to","which","the","DNA","is","confined","."),4077738). assertion_content_comment('tOboGo_Proplastid',s("The","precursor","of","other","plastids","."),4022929). assertion_content_comment('tOboGo_ProplastidStroma',s("The","space","enclosed","by","the","double","membrane","of","a","proplastid","."),4022939). assertion_content_comment('tOboGo_ProprioceptionInvolvedInEquilibrioception',s("The","series","of","events","contributing","to","equilibrioception","by","which","an","organism","senses","the","position",",","location",",","orientation",",","and","movement","of","the","body","and","its","parts",".","Proprioception","plays","an","important","role","in","the","ability","of","an","organism","to","perceive","its","orientation","with","respect","to","gravity","."),4118014). assertion_content_comment('tOboGo_Proprioception',s("The","series","of","events","by","which","an","organism","senses","the","position",",","location",",","orientation",",","and","movement","of","the","body","and","its","parts",".","Proprioception","is","mediated","by","proprioceptors",",","sensory","nerve","terminals","found","in","muscles",",","tendons",",","and","joint","capsules",",","which","give","information","concerning","movements","and","position","of","the","body",".","The","receptors","in","the","labyrinth","are","sometimes","also","considered","proprioceptors","."),4045056). assertion_content_comment('tOboGo_ProproteinConvertase1Activity',s("OBSOLETE",".","Catalysis","of","the","release","of","protein","hormones",",","neuropeptides","and","renin","from","their","precursors",",","generally","by","cleavage","of","-Lys-Arg-Xaa","at","the","Arg-Xaa","bond","."),4209543). assertion_content_comment('tOboGo_ProproteinConvertase2ActivatorActivity',s("OBSOLETE",".","Required","for","the","maturation","and","activation","of","proprotein","convertase","2","."),4305063). assertion_content_comment('tOboGo_ProproteinConvertase2Activity',s("OBSOLETE",".","Catalysis","of","the","release","of","protein","hormones","and","neuropeptides","from","their","precursors",",","generally","by","cleavage","of","-Lys-Arg-Xaa","at","the","Arg-Xaa","bond","."),4209528). assertion_content_comment('tOboGo_ProproteinConvertaseActivity',s("OBSOLETE",".","Was","not","defined","before","being","made","obsolete","."),4301597). assertion_content_comment('tOboGo_PropyleneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","propylene",",","an","alkene","produced","by","catalytic","or","thermal","cracking","of","hydrocarbons","or","as","a","by-product","of","petroleum","refining","."),4314456). assertion_content_comment('tOboGo_PropyleneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","propylene",",","an","alkene","produced","by","catalytic","or","thermal","cracking","of","hydrocarbons","or","as","a","by-product","of","petroleum","refining",".","It","is","used","mainly","in","the","preparation","of","alkylates","for","gasoline","and","in","the","production","of","polypropylene",",","acrylonitrile",",","propylene","oxide","and","a","number","of","other","industrial","chemicals","."),4272457). assertion_content_comment('tOboGo_ProsporeContractileRing',s("A","contractile","ring",",","i.e",".","a","cytoskeletal","structure","composed","of","actin","filaments","and","myosin",",","that","forms","beneath","the","plasma","membrane","of","the","prospore","envelope","in","meiotic","cells","in","preparation","for","completing","cytokinesis","."),4054880). assertion_content_comment('tOboGo_ProsporeMembraneLeadingEdge',s("The","region","of","the","prospore","membrane","that","extends","to","surround","the","spore","nucleus",";","coated","with","specific","proteins","that","are","thought","to","play","a","role","in","prospore","membrane","organization","."),4133812). assertion_content_comment('tOboGo_ProsporeMembraneSpindlePoleBodyAttachmentSite',s("The","region","of","the","prospore","membrane","to","which","the","spindle","pole","body","(","SPB",")","is","anchored",";","the","prospore","membrane","extends","from","the","SPB","attachment","site","to","surround","the","spore","nucleus","."),4133889). assertion_content_comment('tOboGo_ProsporeMembrane',s("The","prospore","membrane","is","a","double-membraned","structure","that","extends","from","the","cytoplasmic","face","of","the","spindle","pole","bodies","to","encompass","the","spindle","pole","bodies","and","the","four","nuclear","lobes","that","are","formed","during","meiosis",".","It","helps","isolate","the","meiotic","nuclei","from","the","cytoplasm","during","spore","formation","and","serves","as","a","foundation","for","the","formation","of","the","spore","walls",".","An","example","of","this","component","is","found","in","Schizosaccharomyces","pombe","."),4006974). assertion_content_comment('tOboGo_ProsporeSeptinFilamentArray',s("Arrays","of","septin","filaments",",","or","bars",",","found","in","a","series","of","filamentous","structures",";","observed","in","the","prospore","membrane","during","spore","formation","."),4329507). assertion_content_comment('tOboGo_ProsporeSeptinRing',s("A","tight","ring-shaped","structure","that","forms","in","the","division","plane","at","the","site","of","cytokinesis","in","a","prospore",";","composed","of","septins","as","well","as","septin-associated","proteins","."),4055328). assertion_content_comment('tOboGo_ProstacyclinReceptorActivity',s("Combining","with","prostacyclin","(","PGI","(","2",")",")","to","initiate","a","change","in","cell","activity","."),4305446). assertion_content_comment('tOboGo_ProstacyclinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","prostacyclin","receptor","."),4323826). assertion_content_comment('tOboGo_ProstaglandinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","prostaglandins",",","any","of","a","group","of","biologically","active","metabolites","which","contain","a","cyclopentane","ring","."),4045796). assertion_content_comment('tOboGo_ProstaglandinD2ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","prostaglandin","D2","receptor","."),4323848). assertion_content_comment('tOboGo_ProstaglandinDReceptorActivity',s("Combining","with","prostaglandin","D","(","PGD","(","2",")",")","to","initiate","a","change","in","cell","activity","."),4197786). assertion_content_comment('tOboGo_ProstaglandinEReceptorActivity',s("Combining","with","prostaglandin","E","(","PGE","(","2",")",")","to","initiate","a","change","in","cell","activity","."),4198079). assertion_content_comment('tOboGo_ProstaglandinFReceptorActivity',s("Combining","with","prostaglandin","F","(","PGF","(","2-alpha",")",")","to","initiate","a","change","in","cell","activity","."),4198090). assertion_content_comment('tOboGo_ProstaglandinJReceptorActivity',s("Combining","with","prostaglandin","J","(","PGJ","(","2",")",")",",","a","metabolite","of","prostaglandin","D","(","PGD","(","2",")",")","to","initiate","a","change","in","cell","activity","."),4383407). assertion_content_comment('tOboGo_ProstaglandinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","prostaglandins",",","any","of","a","group","of","biologically","active","metabolites","which","contain","a","cyclopentane","ring","due","to","the","formation","of","a","bond","between","two","carbons","of","a","fatty","acid",".","They","have","a","wide","range","of","biological","activities","."),4045727). assertion_content_comment('tOboGo_ProstaglandinProductionInvolvedInInflammatoryResponse',s("The","synthesis","or","release","of","any","prostaglandin","following","a","stimulus","as","part","of","an","inflammatory","response",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4381668). assertion_content_comment('tOboGo_ProstaglandinReceptorActivity',s("Combining","with","a","prostaglandin","(","PG",")","to","initiate","a","change","in","cell","activity","."),4197784). assertion_content_comment('tOboGo_ProstaglandinSecretionInvolvedInImmuneResponse',s("The","regulated","release","of","a","prostaglandin","that","contributes","to","the","immune","response",".","Prostaglandins","are","a","group","of","biologically","active","metabolites","which","contain","a","cyclopentane","ring","."),4135265). assertion_content_comment('tOboGo_ProstaglandinSecretion',s("The","regulated","release","of","a","prostaglandin",",","any","of","a","group","of","biologically","active","metabolites","which","contain","a","cyclopentane","ring","."),4054700). assertion_content_comment('tOboGo_ProstaglandinThromboxaneTransporterActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4296124). assertion_content_comment('tOboGo_ProstaglandinTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","prostaglandins","from","one","side","of","the","membrane","to","the","other",".","A","prostaglandin","is","any","of","a","group","of","biologically","active","metabolites","which","contain","a","cyclopentane","ring","due","to","the","formation","of","a","bond","between","two","carbons","of","a","fatty","acid",".","They","have","a","wide","range","of","biological","activities","."),4296120). assertion_content_comment('tOboGo_ProstaglandinTransport',s("The","directed","movement","of","prostaglandins","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4054697). assertion_content_comment('tOboGo_ProstanoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","prostanoids",",","any","compound","based","on","or","derived","from","the","prostanoate","structure","."),4045790). assertion_content_comment('tOboGo_ProstanoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","prostanoids",",","any","compound","based","on","or","derived","from","the","prostanoate","structure","."),4045724). assertion_content_comment('tOboGo_ProstanoidReceptorActivity',s("Combining","with","a","prostanoid",",","any","compound","based","on","or","derived","from","the","prostanoate","structure",",","to","initiate","a","change","in","cell","activity","."),4197782). assertion_content_comment('tOboGo_ProstanoidReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","prostanoid","receptor","."),4323759). assertion_content_comment('tOboGo_ProstateEpithelialCordArborizationInvolvedInProstateGlandularAcinusMorphogenesis',s("The","branching","morphogenesis","process","in","which","the","prostate","epithelial","cords","branch","freely","to","create","the","structure","of","the","prostate","acini","."),4116303). assertion_content_comment('tOboGo_ProstateEpithelialCordElongation',s("The","developmental","growth","process","in","which","solid","chords","of","prostate","epithelium","increase","in","length","."),4116835). assertion_content_comment('tOboGo_ProstateFieldSpecification',s("The","process","that","results","in","the","delineation","of","a","specific","region","of","the","urogenital","sinus","epithelium","into","the","area","in","which","the","prostate","gland","will","develop","."),4116785). assertion_content_comment('tOboGo_ProstateGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","prostate","gland","over","time",",","from","its","formation","to","the","mature","structure",".","The","prostate","gland","is","a","partly","muscular",",","partly","glandular","body","that","is","situated","near","the","base","of","the","mammalian","male","urethra","and","secretes","an","alkaline","viscid","fluid","which","is","a","major","constituent","of","the","ejaculatory","fluid","."),4061682). assertion_content_comment('tOboGo_ProstateGlandEpitheliumMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","epithelia","of","the","prostate","gland","are","generated","and","organized",".","An","epithelium","consists","of","closely","packed","cells","arranged","in","one","or","more","layers",",","that","covers","the","outer","surfaces","of","the","body","or","lines","any","internal","cavity","or","tube","."),4110641). assertion_content_comment('tOboGo_ProstateGlandGrowth',s("The","increase","in","size","or","mass","of","the","prostate","gland","where","the","increase","in","size","or","mass","has","the","specific","outcome","of","the","progression","of","the","gland",",","from","its","formation","to","its","mature","state","."),4110702). assertion_content_comment('tOboGo_ProstateGlandMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","prostate","gland","are","generated","and","organized","."),4110619). assertion_content_comment('tOboGo_ProstateGlandMorphogeneticGrowth',s("The","differential","increase","in","size","or","mass","of","the","prostate","gland","that","contributes","to","the","gland","attaining","its","form","."),4110705). assertion_content_comment('tOboGo_ProstateGlandStromalMorphogenesis',s("The","process","in","which","the","prostate","gland","stroma","is","generated","and","organized",".","The","prostate","gland","stroma","is","made","up","of","the","mesenchymal","or","fibroblast","cells","of","the","prostate","gland","."),4110630). assertion_content_comment('tOboGo_ProstateGlandularAcinusDevelopment',s("The","progression","of","a","glandular","acinus","of","the","prostate","gland","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","glandular","acini","are","the","saclike","structures","of","the","gland","."),4116283). assertion_content_comment('tOboGo_ProstateGlandularAcinusMorphogenesis',s("The","process","in","which","the","prostate","glandular","acini","are","generated","and","organized",".","The","glandular","acini","are","the","saclike","structures","of","the","gland","."),4116293). assertion_content_comment('tOboGo_ProstateInduction',s("The","close","range","interaction","of","the","urogenital","sinus","mesenchyme","and","the","urogenital","sinus","epithelium","that","causes","the","cells","of","the","urogenital","sinus","epithelium","to","change","their","fates","and","specify","the","development","of","the","prostate","gland","."),4116787). assertion_content_comment('tOboGo_ProstaticBudFormation',s("The","morphogenetic","process","in","which","a","region","of","the","fetal","urogenital","sinus","epithelium","is","specified","to","become","the","prostate",",","resulting","in","prostate","bud","outgrowth","."),4112265). assertion_content_comment('tOboGo_ProstheticGroupBinding',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","prosthetic","group",",","the","non-amino","acid","portion","of","certain","protein","molecules","."),4287404). assertion_content_comment('tOboGo_ProstheticGroupBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","prosthetic","group",",","the","non-amino","acid","portion","of","certain","protein","molecules",".","Prosthetic","groups","may","be","inorganic","or","organic","and","are","usually","required","for","the","biological","activity","of","the","protein","."),4119701). assertion_content_comment('tOboGo_ProstheticGroupCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","prosthetic","group",",","the","non-amino","acid","portion","of","certain","protein","molecules",".","Prosthetic","groups","may","be","inorganic","or","organic","and","are","usually","required","for","the","biological","activity","of","the","protein","."),4119719). assertion_content_comment('tOboGo_ProstheticGroupMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","prosthetic","group",",","the","non-amino","acid","portion","of","certain","protein","molecules",".","Prosthetic","groups","may","be","inorganic","or","organic","and","are","usually","required","for","the","biological","activity","of","the","protein","."),4119558). assertion_content_comment('tOboGo_ProteaseBinding',s("Interacting","selectively","and","non-covalently","with","any","protease","or","peptidase","."),4374195). assertion_content_comment('tOboGo_ProteaseIVActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4248195). assertion_content_comment('tOboGo_ProteaseLocalizationInMastCellSecretoryGranule',s("Any","process","in","which","a","protease","is","transported","to",",","or","maintained","in",",","a","location","within","a","secretory","granule","in","a","mast","cell","."),4063241). assertion_content_comment('tOboGo_ProteaseLocalizationInTCellSecretoryGranule',s("Any","process","in","which","a","protease","is","transported","to",",","or","maintained","in",",","a","location","within","a","secretory","granule","in","a","T","cell","."),4063164). assertion_content_comment('tOboGo_ProteaseSubstrateRecruitmentFactorActivity',s("OBSOLETE",".","A","recruiting","factor","or","adaptor","molecule","associated","with","the","proteasome","that","activates","degradation","of","specific","proteasomal","substrates","and","links","them","to","the","degradation","machinery",";","it","is","not","involved","in","ubiquitination",";","does","not","possess","proteolytic","activity","."),4310151). assertion_content_comment('tOboGo_ProteasomalProteinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds","that","is","mediated","by","the","proteasome","."),4012075). assertion_content_comment('tOboGo_ProteasomalProteolysisAssociatedWithAntigenProcessingAndPresentation',s("The","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","by","the","proteasome","complex","contributing","to","antigen","processing","and","presentation","."),4380634). assertion_content_comment('tOboGo_ProteasomeAccessoryComplex',s("A","protein","complex",",","that","caps","one","or","both","ends","of","the","proteasome","core","complex","and","regulates","entry","into",",","or","exit","from",",","the","proteasome","core","complex","."),4008621). assertion_content_comment('tOboGo_ProteasomeActivatorActivity',s("OBSOLETE",".","Catalysis","of","the","activation","of","the","proteasome",",","a","large","multisubunit","complex","which","performs","regulated","ubiquitin-dependent","cytosolic","and","nuclear","proteolysis","."),4254834). assertion_content_comment('tOboGo_ProteasomeActivatorComplex',s("A","multisubunit","complex","that","activates","the","hydrolysis","of","small","nonubiquitinated","peptides","by","binding","to","the","proteasome","core","complex","."),4020294). assertion_content_comment('tOboGo_ProteasomeAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","mature",",","active","proteasome","complex","."),4150900). assertion_content_comment('tOboGo_ProteasomeATPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",".","The","hydrolysis","of","ATP","for","channel","gating","and","polypeptide","unfolding","before","proteolysis","in","the","proteasome",".","Six","ATPase","subunits","are","present","in","the","regulatory","particle","(","RP",")","of","26S","proteasome","."),4252544). assertion_content_comment('tOboGo_ProteasomeBinding',s("Interacting","selectively","and","non-covalently","with","a","proteasome",",","a","large","multisubunit","protein","complex","that","catalyzes","protein","degradation","."),4177047). assertion_content_comment('tOboGo_ProteasomeComplex',s("A","large","multisubunit","complex","which","catalyzes","protein","degradation",".","This","complex","consists","of","the","barrel","shaped","proteasome","core","complex","and","one","or","two","associated","proteins","or","complexes","that","act","in","regulating","entry","into","or","exit","from","the","core","."),4008618). assertion_content_comment('tOboGo_ProteasomeCoreComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","mature",",","active","20S","proteasome","core","particle","complex","that","does","not","contain","any","regulatory","particles","."),4150905). assertion_content_comment('tOboGo_ProteasomeCoreComplex',s("A","multisubunit","barrel","shaped","endoprotease","complex",",","which","is","the","core","of","the","proteasome","complex","."),4008648). assertion_content_comment('tOboGo_ProteasomeEndopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","at","peptide","bonds","with","very","broad","specificity","."),4209699). assertion_content_comment('tOboGo_ProteasomeEndopeptidaseCore',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4302594). assertion_content_comment('tOboGo_ProteasomeEndopeptidaseRegulator',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4302555). assertion_content_comment('tOboGo_ProteasomeInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","the","proteasome","complex",".","The","proteasome","complex","performs","regulated","ubiquitin-dependent","cytosolic","and","nuclear","proteolysis","."),4254847). assertion_content_comment('tOboGo_ProteasomeLocalization',s("Any","process","in","which","the","proteasome","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4318838). assertion_content_comment('tOboGo_ProteasomeRegulatorActivity',s("OBSOLETE",".","Modulates","the","activity","of","the","proteasome","complex",".","The","proteasome","complex","performs","regulated","ubiquitin-dependent","cytosolic","and","nuclear","proteolysis","."),4335950). assertion_content_comment('tOboGo_ProteasomeRegulatoryParticleAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","mature",",","active","proteasome","regulatory","particle","complex","."),4177296). assertion_content_comment('tOboGo_ProteasomeRegulatoryParticleBaseSubcomplex',s("The","subcomplex","of","the","proteasome","regulatory","particle","that","directly","associates","with","the","proteasome","core","complex","."),4020283). assertion_content_comment('tOboGo_ProteasomeRegulatoryParticleLidSubcomplex',s("The","subcomplex","of","the","proteasome","regulatory","particle","that","forms","the","peripheral","lid",",","which","is","added","on","top","of","the","base","subcomplex","."),4020272). assertion_content_comment('tOboGo_ProteasomeRegulatoryParticle',s("A","multisubunit","complex",",","which","caps","one","or","both","ends","of","the","proteasome","core","complex",".","This","complex","recognizes","and","unfolds","ubiquitinated","proteins",",","and","translocates","them","to","the","proteasome","core","complex","."),4008632). assertion_content_comment('tOboGo_ProteasomeRegulatoryParticleSensuBacteria',s("OBSOLETE",".","A","multisubunit","complex","that","recognizes","and","unfolds","ubiquitinated","proteins",",","and","translocates","them","to","the","core","complex","in","an","ATP","dependent","manner",".","As","in",",","but","not","restricted","to",",","the","taxon","Bacteria","(","Bacteria",",","ncbi_taxonomy_id",":","2",")"),4362314). assertion_content_comment('tOboGo_ProteasomeStorageGranule',s("A","multisubunit","proteasome","complex","that","localizes","in","the","cytoplasm","as","dot-like","structures","when","cells","are","in","a","quiescent","state","."),4352118). assertion_content_comment('tOboGo_ProtectionFromNaturalKillerCellMediatedCytotoxicity',s("The","process","of","protecting","a","cell","from","natural","killer","cell","mediated","cytotoxicity","."),4314511). assertion_content_comment('tOboGo_ProteinaceousExtracellularMatrix',s("A","layer","consisting","mainly","of","proteins","(","especially","collagen",")","and","glycosaminoglycans","(","mostly","as","proteoglycans",")","that","forms","a","sheet","underlying","or","overlying","cells","such","as","endothelial","and","epithelial","cells",".","The","proteins","are","secreted","by","cells","in","the","vicinity",".","An","example","of","this","component","is","found","in","Mus","musculus","."),4006813). assertion_content_comment('tOboGo_ProteinAcetylation',s("The","addition","of","an","acetyl","group","to","a","protein","amino","acid",".","An","acetyl","group","is","CH3CO-",",","derived","from","acetic","[","ethanoic","]","acid","."),4072843). assertion_content_comment('tOboGo_ProteinAcetyltransferaseComplex',s("A","complex","that","catalyzes","the","transfer","of","an","acetyl","group","to","a","protein","acceptor","molecule","."),4259845). assertion_content_comment('tOboGo_ProteinActivationCascade',s("A","response","to","a","stimulus","that","consists","of","a","sequential","series","of","modifications","to","a","set","of","proteins","where","the","product","of","one","reaction","acts","catalytically","in","the","following","reaction",".","The","magnitude","of","the","response","is","typically","amplified","at","each","successive","step","in","the","cascade",".","Modifications","typically","include","proteolysis","or","covalent","modification",",","and","may","also","include","binding","events","."),3986102). assertion_content_comment('tOboGo_ProteinAcylation',s("The","addition","of","an","acyl","group",",","any","group","or","radical","of","the","form","RCO-","where","R","is","an","organic","group",",","to","a","protein","amino","acid","."),4072840). assertion_content_comment('tOboGo_ProteinAdenylylation',s("The","addition","of","phospho-adenosine","to","a","protein","amino","acid","."),4279471). assertion_content_comment('tOboGo_ProteinAdenylyltransferaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","protein","=","diphosphate","+","adenylyl-protein",";","mediates","the","addition","of","an","adenylyl","(","adenosine","5","'","-monophosphate",";","AMP","group",")","to","specific","residues","of","target","proteins","."),4176214). assertion_content_comment('tOboGo_ProteinAlkylation',s("The","addition","of","an","alkyl","group","to","a","protein","amino","acid",".","An","alkyl","group","is","any","group","derived","from","an","alkane","by","removal","of","one","hydrogen","atom","."),3975461). assertion_content_comment('tOboGo_ProteinAmidation',s("Addition","of","an","amide","group","from","a","glycine","to","a","protein","amino","acid","."),4282906). assertion_content_comment('tOboGo_ProteinAminoAcidCinnamylation',s("OBSOLETE",".","The","modification","of","a","protein","amino","acid","by","cinnamylation","."),4279673). assertion_content_comment('tOboGo_ProteinAminoAcidTerminalGlycosylation',s("A","protein","amino","acid","glycosylation","process","in","which","a","sugar","unit","is","added","to","a","free","alpha-amino","or","alpha-carboxyl","terminal","of","a","peptide","."),4231133). assertion_content_comment('tOboGo_ProteinAnchor',s("Interacting","selectively","and","non-covalently","with","both","a","protein","or","protein","complex","and","a","membrane",",","in","order","to","maintain","the","localization","of","the","protein","at","a","specific","location","on","the","membrane","."),4325073). assertion_content_comment('tOboGo_ProteinArginylation',s("The","conjugation","of","arginine","to","the","N-terminal","aspartate","or","glutamate","of","a","protein",";","required","for","the","degradation","of","the","protein","via","the","ubiquitin","pathway","."),4040738). assertion_content_comment('tOboGo_ProteinaseActivatedReceptorActivity',s("A","G-protein","coupled","peptide","receptor","activity","that","is","initiated","by","cleavage","of","the","N","terminus","of","the","receptor","by","a","serine","protease",",","resulting","in","the","generation","of","a","new","tethered","ligand","that","interacts","with","the","receptor","."),4384049). assertion_content_comment('tOboGo_ProteinaseActivatedReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","proteinase","activated","receptor","."),4323773). assertion_content_comment('tOboGo_ProteinAutophosphorylation',s("The","phosphorylation","by","a","protein","of","one","or","more","of","its","own","amino","acid","residues",",","or","residues","on","an","identical","protein","."),4057317). assertion_content_comment('tOboGo_ProteinAutoprocessing',s("Processing","which","a","protein","carries","out","itself",".","This","involves","actions","such","as","the","autolytic","removal","of","residues","to","generate","the","mature","form","of","the","protein","."),4305328). assertion_content_comment('tOboGo_ProteinAutoubiquitination',s("The","ubiquitination","by","a","protein","of","one","or","more","of","its","own","amino","acid","residues",",","or","residues","on","an","identical","protein",".","Ubiquitination","occurs","on","the","lysine","residue","by","formation","of","an","isopeptide","crosslink","."),4282079). assertion_content_comment('tOboGo_ProteinBindingBridging',s("The","binding","activity","of","a","molecule","that","brings","together","two","or","more","protein","molecules",",","or","a","protein","and","another","macromolecule","or","complex",",","permitting","those","molecules","to","function","in","a","coordinated","way","."),4074015). assertion_content_comment('tOboGo_ProteinBindingInvolvedInProteinFolding',s("Interacting","selectively","and","non-covalently","with","any","protein","or","protein","complex","(","a","complex","of","two","or","more","proteins","that","may","include","other","nonprotein","molecules",")","that","contributes","to","the","process","of","protein","folding","."),4192274). assertion_content_comment('tOboGo_ProteinBinding',s("Interacting","selectively","and","non-covalently","with","any","protein","or","protein","complex","(","a","complex","of","two","or","more","proteins","that","may","include","other","nonprotein","molecules",")"),4052573). assertion_content_comment('tOboGo_ProteinBindingTranscriptionFactorActivity',s("Interacting","selectively","and","non-covalently","with","a","specific","protein","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","DNA","as","well","."),4192735). assertion_content_comment('tOboGo_ProteinBiosyntheticProcessInhibitorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4258025). assertion_content_comment('tOboGo_ProteinBiotinylation',s("The","addition","of","biotin","(","vitamin","B7","/","vitamin","H",")","to","a","protein","amino","acid","."),4164436). assertion_content_comment('tOboGo_ProteinBody',s("A","membrane-bounded","plant","organelle","found","in","the","developing","endosperm",",","contains","storage","proteins","."),4316926). assertion_content_comment('tOboGo_ProteinBranchingPointDeglutamylation',s("The","removal","of","a","branching","point","glutamate","residue",".","A","branching","point","glutamate","connects","a","glutamate","side","chain","to","a","gene-encoded","glutamate","residue","."),4379918). assertion_content_comment('tOboGo_ProteinBromination',s("The","addition","of","one","or","more","bromine","atoms","to","an","amino","acid","residue","in","a","protein","."),4282707). assertion_content_comment('tOboGo_ProteinCActivatedActivity',s("OBSOLETE",".","Catalysis","of","the","degradation","of","blood","coagulation","factors","Va","and","VIIIa","."),4187830). assertion_content_comment('tOboGo_ProteinCarbamoylation',s("The","addition","of","a","carbamoyl","group","to","a","protein","amino","acid",".","A","carbamoyl","group","is","the","acyl","group","-CO-NH2","."),4362064). assertion_content_comment('tOboGo_ProteinCarboxylation',s("The","addition","of","a","carboxy","group","to","a","protein","amino","acid","."),4233500). assertion_content_comment('tOboGo_ProteinCatabolicProcessByPepsin',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","by","pepsin","in","the","stomach",".","Pepsin","is","generated","from","its","precursor","pepsinogen",",","which","is","activated","by","hydrolchloric","acid","(","gastric","acid",")"),4288054). assertion_content_comment('tOboGo_ProteinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","by","the","destruction","of","the","native",",","active","configuration",",","with","or","without","the","hydrolysis","of","peptide","bonds","."),3990234). assertion_content_comment('tOboGo_ProteinCatenaneFormation',s("The","aggregation",",","arrangement","and","bonding","together","of","a","protein","structure","comprising","two","or","more","rings","that","are","interlocked","but","not","covalently","joined",";","resembling","the","links","of","a","chain","."),4233087). assertion_content_comment('tOboGo_ProteinChannelActivity',s("Catalysis","of","energy-independent","facilitated","diffusion",",","mediated","by","passage","of","proteins","through","a","transmembrane","aqueous","pore","or","channel","."),4295318). assertion_content_comment('tOboGo_ProteinComplexAssemblyInvolvedInSynapseMaturation',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","protein","complex","that","contributes","to","synapse","maturation","."),4149058). assertion_content_comment('tOboGo_ProteinComplexAssemblyMultichaperonePathway',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4223953). assertion_content_comment('tOboGo_ProteinComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","protein","complex","."),3970389). assertion_content_comment('tOboGo_ProteinComplexBinding',s("Interacting","selectively","and","non-covalently","with","any","protein","complex","(","a","complex","of","two","or","more","proteins","that","may","include","other","nonprotein","molecules",")"),4168094). assertion_content_comment('tOboGo_ProteinComplexBiogenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","protein","complex",".","Includes","the","synthesis","of","the","constituent","protein","molecules",",","and","those","protein","modifications","that","are","involved","in","synthesis","or","assembly","of","the","complex","."),3970386). assertion_content_comment('tOboGo_ProteinComplexDisassembly',s("The","disaggregation","of","a","protein","complex","into","its","constituent","components",".","Protein","complexes","may","have","other","associated","non-protein","prosthetic","groups",",","such","as","nucleic","acids",",","metal","ions","or","carbohydrate","groups","."),3970631). assertion_content_comment('tOboGo_ProteinComplexLocalization',s("A","localization","process","that","acts","on","a","protein","complex",";","the","complex","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4108545). assertion_content_comment('tOboGo_ProteinComplexOligomerization',s("The","association","of","two","or","more","multisubunit","protein","complexes","to","form","dimers","or","other","multimers","of","a","protein","complex","."),4381133). assertion_content_comment('tOboGo_ProteinComplex',s("Any","macromolecular","complex","composed","of","two","or","more","polypeptide","subunits",",","which","may","or","may","not","be","identical",".","Protein","complexes","may","have","other","associated","non-protein","prosthetic","groups",",","such","as","nucleotides",",","metal","ions","or","other","small","molecules","."),3971347). assertion_content_comment('tOboGo_ProteinComplexScaffold',s("Functions","to","provide","a","physical","support","for","the","assembly","of","a","multiprotein","complex","."),4215446). assertion_content_comment('tOboGo_ProteinComplexSubunitOrganization',s("Any","process","in","which","macromolecules","aggregate",",","disaggregate",",","or","are","modified",",","resulting","in","the","formation",",","disassembly",",","or","alteration","of","a","protein","complex","."),3970374). assertion_content_comment('tOboGo_ProteinDeacetylaseActivity',s("Catalysis","of","the","hydrolysis","of","an","acetyl","group","or","groups","from","a","protein","substrate","."),4206220). assertion_content_comment('tOboGo_ProteinDeacetylation',s("The","removal","of","an","acetyl","group","from","a","protein","amino","acid",".","An","acetyl","group","is","CH3CO-",",","derived","from","acetic","[","ethanoic","]","acid","."),4062733). assertion_content_comment('tOboGo_ProteinDeacylation',s("The","removal","of","an","acyl","group",",","any","group","or","radical","of","the","form","RCO-","where","R","is","an","organic","group",",","from","a","protein","amino","acid","."),4062730). assertion_content_comment('tOboGo_ProteinDealkylation',s("The","removal","of","an","alkyl","group","from","a","protein","amino","acid",".","An","alkyl","group","is","any","group","derived","from","an","alkane","by","removal","of","one","hydrogen","atom","."),4171580). assertion_content_comment('tOboGo_ProteinDeamination',s("The","removal","of","an","amino","group","from","a","protein","amino","acid","."),4280529). assertion_content_comment('tOboGo_ProteinDecanoylation',s("The","modification","of","a","protein","amino","acid","by","formation","of","an","ester","or","amide","with","decanoic","acid","."),4286148). assertion_content_comment('tOboGo_ProteinDeglutamylation',s("The","removal","of","a","glutamate","residue","from","a","protein",".","Glutamate","residues","in","proteins","can","be","gene-encoded",",","or","added","as","side","chains","during","the","protein","modification","process","of","polyglutamylation","."),4379874). assertion_content_comment('tOboGo_ProteinDeglutathionylation',s("The","protein","modification","process","in","which","a","glutathione","molecule","is","removed","from","a","protein","amino","acid","by","breaking","a","disulfide","linkage","."),4182711). assertion_content_comment('tOboGo_ProteinDeglycosylation',s("The","removal","of","sugar","residues","from","a","glycosylated","protein","."),4231304). assertion_content_comment('tOboGo_ProteinDegradationTaggingActivity',s("OBSOLETE",".","Covalent","addition","of","polyubiquitin","to","another","protein",",","targeting","the","tagged","protein","for","destruction","."),4346519). assertion_content_comment('tOboGo_ProteinDehydration',s("The","removal","of","a","water","group","from","a","protein","amino","acid","."),4280187). assertion_content_comment('tOboGo_ProteinDelipidation',s("The","breakage","of","covalent","bonds","to","detach","lipid","groups","from","a","protein","."),4285373). assertion_content_comment('tOboGo_ProteinDemethylation',s("The","removal","of","a","methyl","group",",","from","a","protein","amino","acid",".","A","methyl","group","is","derived","from","methane","by","the","removal","of","a","hydrogen","atom","."),4171593). assertion_content_comment('tOboGo_ProteinDeneddylation',s("The","removal","of","a","ubiquitin-like","protein","of","the","NEDD8","type","from","a","protein","."),4111379). assertion_content_comment('tOboGo_ProteinDepalmitoylation',s("The","removal","of","palymitoyl","groups","from","a","lipoprotein","."),4373333). assertion_content_comment('tOboGo_ProteinDephosphorylation',s("The","process","of","removing","one","or","more","phosphoric","residues","from","a","protein","."),4071138). assertion_content_comment('tOboGo_ProteinDepolymerization',s("The","process","in","which","protein","polymers",",","compounds","composed","of","a","large","number","of","component","monomers",",","are","broken","down",".","Depolymerization","occurs","by","the","successive","removal","of","monomers","from","an","existing","poly-","or","oligomeric","protein","."),4012715). assertion_content_comment('tOboGo_ProteinDestabilization',s("Any","process","that","decreases","the","stability","of","a","protein",",","making","it","more","vulnerable","to","degradative","processes","or","aggregation","."),4322222). assertion_content_comment('tOboGo_ProteinDesulfurization',s("The","removal","of","a","sulfur","group","from","a","protein","amino","acid","."),4284432). assertion_content_comment('tOboGo_ProteinDesumoylation',s("The","process","in","which","a","SUMO","protein","(","small","ubiquitin-related","modifier",")","is","cleaved","from","its","target","protein","."),4115508). assertion_content_comment('tOboGo_ProteinDeubiquitination',s("The","removal","of","one","or","more","ubiquitin","groups","from","a","protein","."),4125933). assertion_content_comment('tOboGo_ProteinDigestion',s("The","whole","of","the","physical",",","chemical",",","and","biochemical","processes","carried","out","by","living","organisms","to","break","down","ingested","proteins","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),3991765). assertion_content_comment('tOboGo_ProteinDimerizationActivity',s("The","formation","of","a","protein","dimer",",","a","macromolecular","structure","consists","of","two","noncovalently","associated","identical","or","nonidentical","subunits","."),4314744). assertion_content_comment('tOboGo_ProteinDisulfideIsomeraseActivity',s("Catalysis","of","the","rearrangement","of","both","intrachain","and","interchain","disulfide","bonds","in","proteins","."),4192492). assertion_content_comment('tOboGo_ProteinDisulfideOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","a","protein","with","reduced","sulfide","groups","=","a","protein","with","oxidized","disulfide","bonds","."),4297012). assertion_content_comment('tOboGo_ProteinDomainSpecificBinding',s("Interacting","selectively","and","non-covalently","with","a","specific","domain","of","a","protein","."),4073813). assertion_content_comment('tOboGo_ProteinEsterification',s("The","addition","of","an","ester","group","to","a","protein","amino","acid","."),4245085). assertion_content_comment('tOboGo_ProteinExitFromEndoplasmicReticulum',s("The","directed","movement","of","proteins","from","the","endoplasmic","reticulum","."),4132205). assertion_content_comment('tOboGo_ProteinExportFromNucleus',s("The","directed","movement","of","a","protein","from","the","nucleus","into","the","cytoplasm","."),4099346). assertion_content_comment('tOboGo_ProteinFarnesylation',s("The","covalent","attachment","of","a","farnesyl","group","to","a","protein","."),4231288). assertion_content_comment('tOboGo_ProteinFarnesyltransferaseActivity',s("Catalysis","of","the","reaction",":","farnesyl","diphosphate","+","protein-cysteine","=","S-farnesyl","protein","+","diphosphate","."),4202397). assertion_content_comment('tOboGo_ProteinFarnesyltransferaseComplex',s("A","protein","complex","that","possesses","protein","farnesyltransferase","activity","."),4221084). assertion_content_comment('tOboGo_ProteinFlavinylation',s("The","addition","of","a","flavin","group","to","a","protein","amino","acid","."),4268937). assertion_content_comment('tOboGo_ProteinFoldingInEndoplasmicReticulum',s("A","protein","folding","process","that","takes","place","in","the","endoplasmic","reticulum","(","ER",")","Secreted",",","plasma","membrane","and","organelle","proteins","are","folded","in","the","ER",",","assisted","by","chaperones","and","foldases","(","protein","disulphide","isomerases",")",",","and","additional","factors","required","for","optimal","folding","(","ATP",",","Ca2","+","and","an","oxidizing","environment","to","allow","disulfide","bond","formation",")"),4114174). assertion_content_comment('tOboGo_ProteinFolding',s("The","process","of","assisting","in","the","covalent","and","noncovalent","assembly","of","single","chain","polypeptides","or","multisubunit","complexes","into","the","correct","tertiary","structure","."),4013184). assertion_content_comment('tOboGo_ProteinFormylation',s("The","addition","of","a","formyl","group","to","a","protein","amino","acid","."),4280254). assertion_content_comment('tOboGo_ProteinGalactosylationAtCellSurface',s("The","addition","of","a","galactose","unit","to","a","protein","amino","acid","at","the","surface","of","a","cell","."),4340426). assertion_content_comment('tOboGo_ProteinGalactosylationInCytosol',s("The","addition","of","a","galactose","unit","to","a","protein","amino","acid","in","the","cytosol","."),4340515). assertion_content_comment('tOboGo_ProteinGalactosylationInEndoplasmicReticulum',s("The","addition","of","a","galactose","unit","to","a","protein","amino","acid","in","the","endoplasmic","reticulum","."),4340414). assertion_content_comment('tOboGo_ProteinGalactosylationInGolgi',s("The","addition","of","a","galactose","unit","to","a","protein","amino","acid","in","any","compartment","of","the","Golgi","apparatus","."),4340437). assertion_content_comment('tOboGo_ProteinGalactosylation',s("The","addition","of","a","galactose","molecule","to","a","protein","amino","acid","."),4313875). assertion_content_comment('tOboGo_ProteinGeranylgeranylation',s("The","covalent","attachment","of","a","geranylgeranyl","group","to","a","protein","."),4145349). assertion_content_comment('tOboGo_ProteinGeranylgeranyltransferaseActivity',s("Catalysis","of","the","covalent","addition","of","a","geranylgeranyl","(","20-carbon","isoprenoid",")","group","via","thioether","linkages","to","a","cysteine","residue","at","or","near","the","C","terminus","of","a","protein","."),4202411). assertion_content_comment('tOboGo_ProteinGlucuronidation',s("The","modification","of","a","protein","by","amino","acid","glucuronidation","."),4281554). assertion_content_comment('tOboGo_ProteinGlucuronylation',s("The","modification","of","a","protein","by","amino","acid","glucuronylation",",","the","addition","of","a","glucuronate","group",",","the","uronic","acid","derived","from","glucose","."),4279577). assertion_content_comment('tOboGo_ProteinGlutathionylation',s("The","protein","modification","process","in","which","a","glutathione","molecule","is","added","to","a","protein","amino","acid","through","a","disulfide","linkage","."),4024472). assertion_content_comment('tOboGo_ProteinGlycosylationAtCellSurface',s("The","addition","of","a","sugar","unit","to","a","protein","amino","acid","at","the","surface","of","a","cell","."),4340350). assertion_content_comment('tOboGo_ProteinGlycosylationInCytosol',s("The","addition","of","a","sugar","unit","to","a","protein","amino","acid","in","the","cytosol","."),4340360). assertion_content_comment('tOboGo_ProteinGlycosylationInEndoplasmicReticulum',s("The","addition","of","a","sugar","unit","to","a","protein","amino","acid","in","the","endoplasmic","reticulum","."),4340370). assertion_content_comment('tOboGo_ProteinGlycosylationInGolgi',s("The","addition","of","a","sugar","unit","to","a","protein","amino","acid","in","any","compartment","of","the","Golgi","apparatus","."),4152114). assertion_content_comment('tOboGo_ProteinGlycosylation',s("A","protein","modification","process","that","results","in","the","addition","of","a","sugar","unit","to","a","protein","amino","acid",",","e.g",".","the","addition","of","glycan","chains","to","proteins","."),4009791). assertion_content_comment('tOboGo_ProteinGuanylylation',s("The","addition","of","phospho-guanosine","to","a","protein","amino","acid","."),4279787). assertion_content_comment('tOboGo_ProteinHalogenation',s("The","addition","of","a","halogen","to","a","protein","amino","acid","."),4281283). assertion_content_comment('tOboGo_ProteinHeterodimerizationActivity',s("Interacting","selectively","and","non-covalently","with","a","nonidentical","protein","to","form","a","heterodimer","."),4361765). assertion_content_comment('tOboGo_ProteinHeterooligomerization',s("The","process","of","creating","protein","oligomers",",","compounds","composed","of","a","small","number",",","usually","between","three","and","ten",",","of","component","monomers","that","are","not","all","identical",".","Oligomers","may","be","formed","by","the","polymerization","of","a","number","of","monomers","or","the","depolymerization","of","a","large","protein","polymer","."),4173751). assertion_content_comment('tOboGo_ProteinHeterotetramerization',s("The","formation","of","a","protein","heterotetramer",",","a","macromolecular","structure","consisting","of","four","noncovalently","associated","subunits",",","of","which","not","all","are","identical","."),4285831). assertion_content_comment('tOboGo_ProteinHeterotrimerization',s("The","formation","of","a","protein","heterotrimer",",","a","macromolecular","structure","consisting","of","three","noncovalently","associated","subunits",",","of","which","not","all","are","identical","."),4173758). assertion_content_comment('tOboGo_ProteinHexamerization',s("The","formation","of","a","protein","hexamer",",","a","macromolecular","structure","consisting","of","six","noncovalently","associated","identical","or","nonidentical","subunits","."),4359777). assertion_content_comment('tOboGo_ProteinHistidineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","protein","L-histidine","=","ADP","+","protein","phospho-L-histidine","."),4202305). assertion_content_comment('tOboGo_ProteinHistidineKinaseBinding',s("Interacting","selectively","and","non-covalently","with","protein","histidine","kinase","."),4324955). assertion_content_comment('tOboGo_ProteinHistidineKinaseComplex',s("A","complex","that","possesses","protein","histidine","kinase","activity","."),4260103). assertion_content_comment('tOboGo_ProteinHomodimerizationActivity',s("Interacting","selectively","and","non-covalently","with","an","identical","protein","to","form","a","homodimer","."),4314746). assertion_content_comment('tOboGo_ProteinHomooligomerizationActivity',s("OBSOLETE",".","Interacting","selectively","with","identical","proteins","to","form","a","homooligomer","."),4314758). assertion_content_comment('tOboGo_ProteinHomooligomerization',s("The","process","of","creating","protein","oligomers",",","compounds","composed","of","a","small","number",",","usually","between","three","and","ten",",","of","identical","component","monomers",".","Oligomers","may","be","formed","by","the","polymerization","of","a","number","of","monomers","or","the","depolymerization","of","a","large","protein","polymer","."),4055464). assertion_content_comment('tOboGo_ProteinHomotetramerization',s("The","formation","of","a","protein","homotetramer",",","a","macromolecular","structure","consisting","of","four","noncovalently","associated","identical","subunits","."),4285802). assertion_content_comment('tOboGo_ProteinHomotrimerization',s("The","formation","of","a","protein","homotrimer",",","a","macromolecular","structure","consisting","of","three","noncovalently","associated","identical","subunits","."),4173719). assertion_content_comment('tOboGo_ProteinHydroxylation',s("The","addition","of","a","hydroxy","group","to","a","protein","amino","acid","."),4231194). assertion_content_comment('tOboGo_ProteinImportIntoChloroplastStroma',s("The","import","of","proteins","into","the","chloroplast","stroma",".","Import","depends","on","ATP","hydrolysis","catalyzed","by","stromal","chaperones",".","Chloroplast","stromal","proteins",",","such","as","the","S","subunit","of","rubisco",",","have","a","N-terminal","stromal-import","sequence","of","about","44","amino","acids","which","is","cleaved","from","the","protein","precursor","after","import","."),4300896). assertion_content_comment('tOboGo_ProteinImportIntoChloroplastThylakoidMembrane',s("The","import","of","proteins","into","the","chloroplast","thylakoid","membranes",".","Proteins","that","are","destined","for","the","thylakoid","lumen","require","two","uptake-targeting","sequences",":","the","first","targets","the","protein","to","the","stroma",",","and","the","second","targets","the","protein","from","the","stroma","to","the","thylakoid","lumen",".","Four","separate","thylakoid-import","systems","deal","with","the","proteins","once","they","are","in","the","stroma","."),4300883). assertion_content_comment('tOboGo_ProteinImportIntoMitochondrialInnerMembrane',s("The","import","of","proteins","into","the","mitochondria","inner","membrane",".","Inner","membrane","proteins","are","first","imported","into","the","matrix","space","where","the","matrix-targeting","sequence","is","removed",";","how","these","proteins","then","are","incorporated","into","the","inner","membrane","is","not","known","."),4300790). assertion_content_comment('tOboGo_ProteinImportIntoMitochondrialIntermembraneSpaceConservative',s("OBSOLETE",".","The","conservative","import","of","proteins","into","the","mitochondrial","intermembrane","space",".","The","entire","protein","enters","the","matrix",",","and","then","the","second","targeting","sequence","directs","the","protein",",","presumably","bound","to","a","matrix","protein",",","across","the","inner","membrane","to","the","intermembrane","space","."),4300814). assertion_content_comment('tOboGo_ProteinImportIntoMitochondrialIntermembraneSpace',s("The","import","of","proteins","into","the","space","between","the","inner","and","outer","mitochondrial","membranes","."),4300805). assertion_content_comment('tOboGo_ProteinImportIntoMitochondrialMatrix',s("The","import","of","proteins","across","the","outer","and","inner","mitochondrial","membranes","into","the","matrix",".","Unfolded","proteins","enter","the","mitochondrial","matrix","with","a","chaperone","protein",";","the","information","required","to","target","the","precursor","protein","from","the","cytosol","to","the","mitochondrial","matrix","is","contained","within","its","N-terminal","matrix-targeting","sequence",".","Translocation","of","precursors","to","the","matrix","occurs","at","the","rare","sites","where","the","outer","and","inner","membranes","are","close","together","."),4311063). assertion_content_comment('tOboGo_ProteinImportIntoMitochondrialOuterMembrane',s("The","import","of","proteins","into","the","outer","membrane","of","the","mitochondrion",".","Outer","membrane","proteins","have","a","short","matrix-targeting","sequence","followed","by","a","long","stretch","of","hydrophobic","amino","acids","at","the","N-terminus",".","The","hydrophobic","sequence","functions","as","a","stop-transfer","sequence","that","both","prevents","transfer","of","the","protein","into","the","matrix","and","anchors","it","as","an","integral","protein","in","the","outer","membrane","."),4300832). assertion_content_comment('tOboGo_ProteinImportIntoNucleusDocking',s("A","protein","complex","assembly","process","that","contributes","to","protein","import","into","the","nucleus",",","and","that","results","in","the","association","of","a","cargo","protein",",","a","carrier","protein","such","as","an","importin","alpha/beta","heterodimer",",","and","a","nucleoporin","located","at","the","periphery","of","the","nuclear","pore","complex","."),3970398). assertion_content_comment('tOboGo_ProteinImportIntoNucleus',s("The","directed","movement","of","a","protein","from","the","cytoplasm","to","the","nucleus","."),3970317). assertion_content_comment('tOboGo_ProteinImportIntoNucleusSubstrateRelease',s("A","protein","complex","disassembly","process","that","contributes","to","protein","import","into","the","nucleus",",","and","that","results","in","the","dissociation","of","the","cargo","protein","and","the","carrier","(","such","as","an","importin","alpha/beta","heterodimer",")","from","each","other","and","from","the","nuclear","pore","complex","."),3970636). assertion_content_comment('tOboGo_ProteinImportIntoNucleusTranslocation',s("A","protein","transport","process","that","contributes","to","protein","import","into","the","nucleus",",","and","that","results","in","the","vectorial","transfer","of","a","cargo-carrier","protein","complex","through","the","nuclear","pore","complex","from","the","cytoplasmic","side","to","the","nucleoplasmic","side","of","the","nuclear","envelope","."),3970333). assertion_content_comment('tOboGo_ProteinImportIntoPeroxisomeMatrixDocking',s("The","process","in","which","a","complex","formed","of","a","peroxisome","targeting","sequence","(","PTS",")","receptor","bound","to","a","PTS-bearing","protein","docks","with","translocation","machinery","in","the","preoxisomal","membrane","."),4040634). assertion_content_comment('tOboGo_ProteinImportIntoPeroxisomeMatrixReceptorRecycling',s("The","process","in","which","peroxisome","targeting","sequence","receptors","dissociates","from","cargo","proteins","and","are","returned","to","the","cytosol","."),4040662). assertion_content_comment('tOboGo_ProteinImportIntoPeroxisomeMatrix',s("The","import","of","proteins","into","the","peroxisomal","matrix",".","A","peroxisome","targeting","signal","(","PTS",")","binds","to","a","soluble","receptor","protein","in","the","cytosol",",","and","the","resulting","complex","then","binds","to","a","receptor","protein","in","the","peroxisome","membrane","and","is","imported","."),4040622). assertion_content_comment('tOboGo_ProteinImportIntoPeroxisomeMatrixTranslocation',s("The","process","in","which","proteins","are","moved","across","the","peroxisomal","membrane","into","the","matrix",".","It","is","likely","that","the","peroxisome","targeting","sequence","receptor","remains","associated","with","cargo","proteins","during","translocation","."),4040679). assertion_content_comment('tOboGo_ProteinImportIntoPeroxisomeMembrane',s("The","targeting","of","proteins","into","the","peroxisomal","membrane",".","The","process","is","not","well","understood",",","but","both","signals","and","mechanism","differ","from","those","involved","in","peroxisomal","matrix","protein","import","."),4300744). assertion_content_comment('tOboGo_ProteinImport',s("The","directed","movement","of","proteins","into","a","cell","or","organelle","."),3970277). assertion_content_comment('tOboGo_ProteinInitiatorMethionineRemovalInvolvedInProteinMaturation',s("Removal","of","the","initiating","methionine","or","formylmethionine","residue","from","a","protein","that","contributes","to","protein","maturation",",","the","attainment","of","the","full","functional","capacity","of","a","protein","."),4378598). assertion_content_comment('tOboGo_ProteinInitiatorMethionineRemoval',s("The","protein","modification","process","in","which","the","translation-initiating","methionine","or","formylmethionine","residue","is","removed","from","a","protein","."),4180202). assertion_content_comment('tOboGo_ProteinInsertionIntoERMembraneByGPIAttachmentSequence',s("A","process","of","protein","insertion","into","the","endoplasmic","reticulum","(","ER",")","membrane","in","which","proteins","become","anchored","to","the","phospholipid","bilayer","by","a","covalently","attached","glycosylphosphatidylinositol","(","GPI",")","molecule","."),4301045). assertion_content_comment('tOboGo_ProteinInsertionIntoERMembrane',s("The","process","that","results","in","incorporation","of","a","protein","into","an","endoplasmic","reticulum","(","ER",")","membrane",".","It","depends","on","specific","topogenic","sequences","of","amino","acids","that","ensure","that","a","protein","acquires","the","proper","orientation","during","its","insertion","into","the","ER","membrane","."),4097141). assertion_content_comment('tOboGo_ProteinInsertionIntoMembraneFromInnerSide',s("The","process","in","which","a","protein","is","incorporated","into","a","lipid","bilayer",",","e.g.",",","the","prokaryotic",",","mitochondrial",",","or","chloroplast","inner","membrane",",","from","the","inner","side","."),4337171). assertion_content_comment('tOboGo_ProteinInsertionIntoMembraneRaft',s("The","process","in","which","a","protein","is","incorporated","into","a","membrane","raft",".","Membrane","rafts","are","small","(","10-200","nm",")",",","heterogeneous",",","highly","dynamic",",","sterol-","and","sphingolipid-enriched","membrane","domains","that","compartmentalize","cellular","processes","."),4165289). assertion_content_comment('tOboGo_ProteinInsertionIntoMembrane',s("The","process","that","results","in","the","incorporation","of","a","protein","into","a","biological","membrane","."),3986848). assertion_content_comment('tOboGo_ProteinInsertionIntoMitochondrialMembraneFromInnerSide',s("The","process","in","which","a","protein","is","incorporated","into","the","mitochondrial","membrane","from","the","inner","side",".","This","includes","membrane","insertion","of","newly","synthesized","mitochondrially-encoded","proteins",",","and","insertion","of","nuclear-encoded","proteins","after","their","import","into","the","mitochondrial","matrix","."),4337182). assertion_content_comment('tOboGo_ProteinInsertionIntoMitochondrialMembraneInvolvedInInductionOfApoptosis',s("The","process","in","which","a","protein","is","incorporated","into","a","mitochondrial","membrane",",","contributing","to","the","induction","of","apoptosis","."),3986899). assertion_content_comment('tOboGo_ProteinInsertionIntoMitochondrialMembrane',s("The","process","that","results","in","the","incorporation","of","a","protein","into","a","mitochondrial","membrane","."),3986889). assertion_content_comment('tOboGo_ProteinIodination',s("The","addition","of","one","or","more","iodine","atoms","to","an","amino","acid","residue","in","a","protein","."),4281286). assertion_content_comment('tOboGo_ProteinKinaseAAnchoringActivity',s("OBSOLETE",".","Binds","to","protein","kinase","A","and","anchors","it","to","a","particular","subcellular","location","."),4215427). assertion_content_comment('tOboGo_ProteinKinaseABinding',s("Interacting","selectively","and","non-covalently","with","any","subunit","of","protein","kinase","A","."),4215422). assertion_content_comment('tOboGo_ProteinKinaseACatalyticSubunitBinding',s("Interacting","selectively","and","non-covalently","with","one","or","both","of","the","catalytic","subunits","of","protein","kinase","A","."),4359637). assertion_content_comment('tOboGo_ProteinKinaseActivatorActivity',s("Increases","the","activity","of","a","protein","kinase",",","an","enzyme","which","phosphorylates","a","protein","."),4217303). assertion_content_comment('tOboGo_ProteinKinaseActivity',s("Catalysis","of","the","phosphorylation","of","an","amino","acid","residue","in","a","protein",",","usually","according","to","the","reaction",":","a","protein","+","ATP","=","a","phosphoprotein","+","ADP","."),4157292). assertion_content_comment('tOboGo_ProteinKinaseARegulatorySubunitBinding',s("Interacting","selectively","and","non-covalently","with","one","or","both","of","the","regulatory","subunits","of","protein","kinase","A","."),4359658). assertion_content_comment('tOboGo_ProteinKinaseASignalingCascade',s("A","series","of","reactions",",","mediated","by","the","intracellular","serine/threonine","kinase","protein","kinase","A",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4024517). assertion_content_comment('tOboGo_ProteinKinaseBBinding',s("Interacting","selectively","and","non-covalently","with","protein","kinase","B",",","an","intracellular","kinase","that","is","important","in","regulating","glucose","metabolism","."),4324710). assertion_content_comment('tOboGo_ProteinKinaseBinding',s("Interacting","selectively","and","non-covalently","with","a","protein","kinase",",","any","enzyme","that","catalyzes","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","protein","substrate","."),4073910). assertion_content_comment('tOboGo_ProteinKinaseBSignalingCascade',s("A","series","of","reactions",",","mediated","by","the","intracellular","serine/threonine","kinase","protein","kinase","B",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4120084). assertion_content_comment('tOboGo_ProteinKinaseCActivity',s("Catalysis","of","the","reaction",":","ATP","+","a","protein","=","ADP","+","a","phosphoprotein",".","This","reaction","requires","diacylglycerol","."),4202613). assertion_content_comment('tOboGo_ProteinKinaseCAlphaBinding',s("Interacting","selectively","and","non-covalently","with","protein","kinase","C","alpha","."),4073915). assertion_content_comment('tOboGo_ProteinKinaseCBinding',s("Interacting","selectively","and","non-covalently","with","protein","kinase","C","."),4073912). assertion_content_comment('tOboGo_ProteinKinaseCDeactivation',s("Any","process","resulting","in","the","inhibition","or","termination","of","the","activity","of","protein","kinase","C","."),4312934). assertion_content_comment('tOboGo_ProteinKinaseCDeltaBinding',s("Interacting","selectively","and","non-covalently","with","protein","kinase","C","delta","."),4157796). assertion_content_comment('tOboGo_ProteinKinaseCEtaBinding',s("Interacting","selectively","and","non-covalently","with","protein","kinase","C","eta","."),4157786). assertion_content_comment('tOboGo_ProteinKinaseCInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","protein","kinase","C",",","an","enzyme","which","phosphorylates","a","protein","."),4253538). assertion_content_comment('tOboGo_ProteinKinaseCK2Activity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","casein","+","ATP","=","phosphocasein","+","ADP","."),4202694). assertion_content_comment('tOboGo_ProteinKinaseCK2Complex',s("A","protein","complex","that","possesses","protein","serine/threonine","kinase","activity",",","and","contains","two","catalytic","alpha","subunits","and","two","regulatory","beta","subunits",".","Protein","kinase","CK2","complexes","are","found","in","nearly","every","subcellular","compartment",",","and","can","phosphorylate","many","protein","substrates","in","addition","to","casein","."),4221228). assertion_content_comment('tOboGo_ProteinKinaseCK2RegulatorActivity',s("OBSOLETE",".","Modulation","of","the","activity","of","the","enzyme","protein","kinase","CK2","."),4253179). assertion_content_comment('tOboGo_ProteinKinaseCSignalingCascade',s("A","series","of","reactions",",","mediated","by","the","intracellular","serine/threonine","kinase","protein","kinase","C",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4149944). assertion_content_comment('tOboGo_ProteinKinaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","protein","kinase",",","an","enzyme","which","phosphorylates","a","protein","."),4200314). assertion_content_comment('tOboGo_ProteinKinaseRegulatorActivity',s("Modulates","the","activity","of","a","protein","kinase",",","an","enzyme","which","phosphorylates","a","protein","."),4200278). assertion_content_comment('tOboGo_ProteinLinearPolyubiquitination',s("A","protein","ubiquitination","process","in","which","a","linear","polymer","of","ubiquitin",",","formed","by","the","amino-terminal","methionine","(","M1",")","of","one","ubiquitin","molecule","and","by","the","carboxy-terminal","glycine","(","G76",")","of","the","next",",","is","added","to","a","protein","."),4074256). assertion_content_comment('tOboGo_ProteinLipidation',s("The","covalent","attachment","of","lipid","groups","to","an","amino","acid","in","a","protein","."),4009720). assertion_content_comment('tOboGo_ProteinLipoylation',s("The","addition","of","a","lipoyl","group","to","an","amino","acid","residue","in","a","protein","."),4257403). assertion_content_comment('tOboGo_ProteinLocalizationAtCellSurface',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","the","external","part","of","the","cell","wall","and/or","plasma","membrane","."),4139353). assertion_content_comment('tOboGo_ProteinLocalizationInEndoplasmicReticulum',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","the","endoplasmic","reticulum","."),4013880). assertion_content_comment('tOboGo_ProteinLocalizationInExtracellularRegion',s("Any","process","in","which","a","protein","is","transported","from","one","specific","location","in","the","extracellular","region","to","another",",","or","maintained","in","a","specific","extracellular","location","."),4082146). assertion_content_comment('tOboGo_ProteinLocalizationInGolgiApparatus',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","the","Golgi","apparatus","."),4097100). assertion_content_comment('tOboGo_ProteinLocalizationInMastCellSecretoryGranule',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","a","secretory","granule","in","a","mast","cell","."),4063238). assertion_content_comment('tOboGo_ProteinLocalizationInMembrane',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","specific","location","in","a","membrane","."),4146836). assertion_content_comment('tOboGo_ProteinLocalizationInMitochondrion',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","the","mitochondrion","."),3986882). assertion_content_comment('tOboGo_ProteinLocalizationInPlasmaMembrane',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","specific","location","in","the","plasma","membrane","."),4146857). assertion_content_comment('tOboGo_ProteinLocalizationInSecretoryGranule',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","a","secretory","granule","."),4063108). assertion_content_comment('tOboGo_ProteinLocalizationInTCellSecretoryGranule',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","a","secretory","granule","in","a","T","cell","."),4063137). assertion_content_comment('tOboGo_ProteinLocalizationInvolvedInAcrosomeReaction',s("The","actin-based","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","specific","location","in","the","sperm","as","part","of","the","acrosome","reaction","."),4117570). assertion_content_comment('tOboGo_ProteinLocalizationInvolvedInEstablishmentOfPlanarPolarity',s("Any","process","in","which","a","protein","is","transported","to",",","and/or","maintained","in",",","a","specific","location","in","a","cell","that","contributes","to","the","establishment","of","planar","polarity","."),4152002). assertion_content_comment('tOboGo_ProteinLocalization',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","specific","location","."),3970224). assertion_content_comment('tOboGo_ProteinLocalizationToAdherensJunction',s("Any","process","in","which","a","protein","is","transported","to",",","and/or","maintained","at","the","adherens","junction","."),4170649). assertion_content_comment('tOboGo_ProteinLocalizationToCentrosome',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","centrosome","."),4172089). assertion_content_comment('tOboGo_ProteinLocalizationToChloroplast',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","a","location","in","a","chloroplast","."),4126569). assertion_content_comment('tOboGo_ProteinLocalizationToChromatin',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","a","part","of","a","chromosome","that","is","organized","into","chromatin","."),4125883). assertion_content_comment('tOboGo_ProteinLocalizationToChromosomeCentromericRegion',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","centromeric","region","of","a","chromosome","."),4163778). assertion_content_comment('tOboGo_ProteinLocalizationToChromosome',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","a","specific","location","on","a","chromosome","."),4125879). assertion_content_comment('tOboGo_ProteinLocalizationToChromosomeTelomericRegion',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","telomeric","region","of","a","chromosome","."),4137402). assertion_content_comment('tOboGo_ProteinLocalizationToEndoplasmicReticulumExitSite',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","at","an","endoplasmic","reticulum","exit","site","."),4177739). assertion_content_comment('tOboGo_ProteinLocalizationToJuxtaparanodeRegionOfAxon',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","juxtaparanode","region","of","an","axon","."),4128844). assertion_content_comment('tOboGo_ProteinLocalizationToKinetochore',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","kinetochore","."),4159045). assertion_content_comment('tOboGo_ProteinLocalizationToMedialCortex',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","the","medial","cortex","."),4171291). assertion_content_comment('tOboGo_ProteinLocalizationToMicrotubule',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","a","microtubule","."),4382931). assertion_content_comment('tOboGo_ProteinLocalizationToMyelinSheathAbaxonalRegion',s("Any","process","in","which","a","protein","is","transported","to",",","and/or","maintained","in",",","the","abaxonal","region","of","the","myelin","sheath",".","The","abaxonal","region","is","the","region","of","the","myelin","sheath","furthest","from","the","axon","."),4381266). assertion_content_comment('tOboGo_ProteinLocalizationToNuclearPore',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","nuclear","pore","."),4155662). assertion_content_comment('tOboGo_ProteinLocalizationToNucleolarRDNARepeats',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","rDNA","repeats","on","a","chromosome","in","the","nucleolus","."),4352273). assertion_content_comment('tOboGo_ProteinLocalizationToNucleus',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","the","nucleus","."),3970312). assertion_content_comment('tOboGo_ProteinLocalizationToOrganelle',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","location","within","an","organelle","."),3970308). assertion_content_comment('tOboGo_ProteinLocalizationToParanodeRegionOfAxon',s("A","cellular","protein","localization","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","paranode","region","of","an","axon","."),4375777). assertion_content_comment('tOboGo_ProteinLocalizationToPeroxisome',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","a","location","in","a","peroxisome","."),4040612). assertion_content_comment('tOboGo_ProteinLocalizationToSpindlePoleBody',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","spindle","pole","body","."),4125770). assertion_content_comment('tOboGo_ProteinLocalizationToSynapse',s("Any","process","in","which","a","protein","is","transported","to",",","and/or","maintained","at","the","synapse",",","the","junction","between","a","nerve","fiber","of","one","neuron","and","another","neuron","or","muscle","fiber","or","glial","cell","."),4376399). assertion_content_comment('tOboGo_ProteinLocalizationToVacuole',s("A","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","a","location","in","a","vacuole","."),4034715). assertion_content_comment('tOboGo_ProteinMannosylation',s("The","addition","of","a","mannose","residue","to","a","protein","acceptor","molecule","."),4281243). assertion_content_comment('tOboGo_ProteinMaturationByPeptideBondCleavage',s("The","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","as","part","of","protein","maturation",",","the","process","leading","to","the","attainment","of","the","full","functional","capacity","of","a","protein","."),3986233). assertion_content_comment('tOboGo_ProteinMaturationByProteinFolding',s("The","process","of","assisting","in","the","covalent","and","noncovalent","assembly","of","single","chain","polypeptides","or","multisubunit","complexes","into","the","correct","tertiary","structure","that","results","in","the","attainment","of","the","full","functional","capacity","of","a","protein","."),4336018). assertion_content_comment('tOboGo_ProteinMaturation',s("Any","process","leading","to","the","attainment","of","the","full","functional","capacity","of","a","protein","."),3986218). assertion_content_comment('tOboGo_ProteinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","specific","protein",",","rather","than","of","proteins","in","general",".","Includes","protein","modification","."),3972258). assertion_content_comment('tOboGo_ProteinMethylation',s("The","addition","of","a","methyl","group","to","a","protein","amino","acid",".","A","methyl","group","is","derived","from","methane","by","the","removal","of","a","hydrogen","atom","."),3975516). assertion_content_comment('tOboGo_ProteinMethylesteraseActivity',s("Catalysis","of","the","reaction",":","protein","amino","acid","methyl","ester","+","H2O","=","protein","amino","acid","+","methanol","."),4248068). assertion_content_comment('tOboGo_ProteinMethyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","methyl","group","(","CH3-",")","to","a","protein","."),4170725). assertion_content_comment('tOboGo_ProteinModificationBySmallProteinConjugationOrRemoval',s("A","protein","modification","process","in","which","one","or","more","groups","of","a","small","protein",",","such","as","ubiquitin","or","a","ubiquitin-like","protein",",","are","covalently","attached","to","or","removed","from","a","target","protein","."),4012318). assertion_content_comment('tOboGo_ProteinModificationBySmallProteinConjugation',s("A","protein","modification","process","in","which","one","or","more","groups","of","a","small","protein",",","such","as","ubiquitin","or","a","ubiquitin-like","protein",",","are","covalently","attached","to","a","target","protein","."),4012320). assertion_content_comment('tOboGo_ProteinModificationBySmallProteinRemoval',s("A","protein","modification","process","in","which","one","or","more","covalently","attached","groups","of","a","small","protein",",","such","as","ubiquitin","or","a","ubiquitin-like","protein",",","are","removed","from","a","target","protein","."),4111377). assertion_content_comment('tOboGo_ProteinModificationProcess',s("The","covalent","alteration","of","one","or","more","amino","acids","occurring","in","proteins",",","peptides","and","nascent","polypeptides","(","co-translational",",","post-translational","modifications",")","Includes","the","modification","of","charged","tRNAs","that","are","destined","to","occur","in","a","protein","(","pre-translation","modification",")"),3972267). assertion_content_comment('tOboGo_ProteinMonoubiquitination',s("Addition","of","a","single","ubiquitin","group","to","a","protein","."),4231314). assertion_content_comment('tOboGo_ProteinMyristoylation',s("The","covalent","attachment","of","a","myristoyl","group","to","a","protein","."),4231084). assertion_content_comment('tOboGo_ProteinNeddylation',s("Covalent","attachment","of","the","ubiquitin-like","protein","NEDD8","(","RUB1",")","to","another","protein","."),4141970). assertion_content_comment('tOboGo_ProteinNitrosylation',s("The","covalent","addition","of","a","nitric","oxide","group","to","an","amino","acid","within","a","protein","."),4141547). assertion_content_comment('tOboGo_ProteinNucleotidylation',s("The","addition","of","a","nucleotide","to","a","protein","amino","acid","."),4279468). assertion_content_comment('tOboGo_ProteinOctanoylation',s("The","modification","of","a","protein","amino","acid","by","formation","of","an","ester","or","amide","with","octanoic","acid","."),4285618). assertion_content_comment('tOboGo_ProteinOligomerization',s("The","process","of","creating","protein","oligomers",",","compounds","composed","of","a","small","number",",","usually","between","three","and","ten",",","of","component","monomers",";","protein","oligomers","may","be","composed","of","different","or","identical","monomers",".","Oligomers","may","be","formed","by","the","polymerization","of","a","number","of","monomers","or","the","depolymerization","of","a","large","protein","polymer","."),4055421). assertion_content_comment('tOboGo_Proteinoplast',s("A","leucoplast","in","which","protein","is","stored","."),4320586). assertion_content_comment('tOboGo_ProteinOxidation',s("The","modification","of","a","protein","amino","acid","by","oxidation","."),4042163). assertion_content_comment('tOboGo_ProteinPalmitoleylation',s("The","covalent","attachment","of","a","palmitoleyl","group","to","a","protein","."),4232912). assertion_content_comment('tOboGo_ProteinPalmitoylation',s("The","covalent","attachment","of","a","palmitoyl","group","to","a","protein","."),4116064). assertion_content_comment('tOboGo_ProteinPhosphatase1Binding',s("Interacting","selectively","and","non-covalently","with","the","enzyme","protein","phosphatase","1","."),4245740). assertion_content_comment('tOboGo_ProteinPhosphatase2ABinding',s("Interacting","selectively","and","non-covalently","with","the","enzyme","protein","phosphatase","2A","."),4280839). assertion_content_comment('tOboGo_ProteinPhosphatase2BBinding',s("Interacting","selectively","and","non-covalently","with","the","enzyme","protein","phosphatase","2B","."),4309487). assertion_content_comment('tOboGo_ProteinPhosphatase4Complex',s("The","complex","formed","by","the","catalytic","subunit","of","protein","phosphatase","4","plus","a","regulatory","subunit","."),4311860). assertion_content_comment('tOboGo_ProteinPhosphataseActivatorActivity',s("Increases","the","activity","of","a","protein","phosphatase",",","an","enzyme","which","catalyzes","of","the","removal","of","a","phosphate","group","from","a","protein","substrate","molecule","."),4157030). assertion_content_comment('tOboGo_ProteinPhosphataseBinding',s("Interacting","selectively","and","non-covalently","with","any","protein","phosphatase","."),4232597). assertion_content_comment('tOboGo_ProteinPhosphataseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","protein","phosphatase",",","an","enzyme","that","hydrolyzes","phosphate","groups","from","phosphorylated","proteins","."),4200240). assertion_content_comment('tOboGo_ProteinPhosphataseRegulatorActivity',s("Modulates","the","activity","of","a","protein","phosphatase",",","an","enzyme","which","catalyzes","of","the","removal","of","a","phosphate","group","from","a","protein","substrate","molecule","."),4157006). assertion_content_comment('tOboGo_ProteinPhosphataseType1ActivatorActivity',s("Increases","the","activity","of","the","enzyme","protein","phosphatase","type","1","."),4170621). assertion_content_comment('tOboGo_ProteinPhosphataseType1Complex',s("A","protein","complex","that","possesses","magnesium-dependent","protein","serine/threonine","phosphatase","(","AMD","phosphatase",")","activity",",","and","consists","of","a","catalytic","subunit","and","one","or","more","regulatory","subunits","that","dictates","the","phosphatase","'","s","substrate","specificity",",","function",",","and","activity","."),4346014). assertion_content_comment('tOboGo_ProteinPhosphataseType1RegulatorActivity',s("Modulation","of","the","activity","of","the","enzyme","protein","phosphatase","type","1","."),4170617). assertion_content_comment('tOboGo_ProteinPhosphataseType2AActivatorActivity',s("Increases","the","activity","of","the","enzyme","protein","phosphatase","type","2A","."),4157032). assertion_content_comment('tOboGo_ProteinPhosphataseType2AComplex',s("A","protein","complex","that","has","protein","serine/threonine","phosphatase","activity","that","is","polycation-stimulated","(","PCS",")",",","being","directly","stimulated","by","protamine",",","polylysine",",","or","histone","H1",";","it","constitutes","a","subclass","of","several","enzymes","activated","by","different","histones","and","polylysine",",","and","consists","of","catalytic",",","scaffolding",",","and","regulatory","subunits",".","The","catalytic","and","scaffolding","subunits","form","the","core","enzyme",",","and","the","holoenzyme","also","includes","the","regulatory","subunit","."),4346150). assertion_content_comment('tOboGo_ProteinPhosphataseType2ARegulatorActivity',s("Modulation","of","the","activity","of","the","enzyme","protein","phosphatase","type","2A","."),4157008). assertion_content_comment('tOboGo_ProteinPhosphataseType2BRegulatorActivity',s("Modulation","of","the","activity","of","the","enzyme","protein","phosphatase","type","2B","."),4309799). assertion_content_comment('tOboGo_ProteinPhosphataseType4RegulatorActivity',s("Modulation","of","the","activity","of","the","enzyme","protein","phosphatase","type","4","."),4309883). assertion_content_comment('tOboGo_ProteinPhosphopantetheinylation',s("The","modification","of","a","protein","amino","acid","by","phosphopantetheinylation","."),4284179). assertion_content_comment('tOboGo_ProteinPhosphorylatedAminoAcidBinding',s("Interacting","selectively","and","non-covalently","with","a","phosphorylated","amino","acid","residue","within","a","protein","."),4274837). assertion_content_comment('tOboGo_ProteinPhosphorylation',s("The","process","of","introducing","a","phosphate","group","on","to","a","protein","."),3972306). assertion_content_comment('tOboGo_ProteinPolyamination',s("The","modification","of","a","protein","amino","acid","by","polyamination","."),4285665). assertion_content_comment('tOboGo_ProteinPolyglutamylation',s("The","addition","of","one","or","more","alpha-linked","glutamyl","units","to","the","gamma","carboxyl","group","of","peptidyl-glutamic","acid","."),4284318). assertion_content_comment('tOboGo_ProteinPolyglycylation',s("The","addition","of","glycyl","units","covalently","bound","to","the","gamma","carboxyl","group","peptidyl-glutamic","acid","."),4284328). assertion_content_comment('tOboGo_ProteinPolymerization',s("The","process","of","creating","protein","polymers",",","compounds","composed","of","a","large","number","of","component","monomers",";","polymeric","proteins","may","be","made","up","of","different","or","identical","monomers",".","Polymerization","occurs","by","the","addition","of","extra","monomers","to","an","existing","poly-","or","oligomeric","protein","."),4005528). assertion_content_comment('tOboGo_ProteinPolyubiquitination',s("Addition","of","multiple","ubiquitin","groups","to","a","protein",",","forming","a","ubiquitin","chain","."),4074251). assertion_content_comment('tOboGo_ProteinPrenylation',s("The","covalent","attachment","of","a","prenyl","group","to","a","protein",";","geranyl",",","farnesyl",",","or","geranylgeranyl","groups","may","be","added","."),4145345). assertion_content_comment('tOboGo_ProteinPrenyltransferaseActivity',s("Catalysis","of","the","covalent","addition","of","an","isoprenoid","group","such","as","a","farnesyl","or","geranylgeranyl","group","via","thioether","linkages","to","a","cysteine","residue","in","a","protein","."),4202395). assertion_content_comment('tOboGo_ProteinProcessingInvolvedInProteinTargetingToMitochondrion',s("The","cleavage","of","peptide","bonds","in","proteins",",","usually","near","the","N","terminus",",","contributing","to","the","process","of","import","into","the","mitochondrion",".","Several","different","peptidases","mediate","cleavage","of","proteins","destined","for","different","mitochondrial","compartments","."),4013822). assertion_content_comment('tOboGo_ProteinProcessing',s("Any","protein","maturation","process","achieved","by","the","cleavage","of","peptide","bonds","."),3986220). assertion_content_comment('tOboGo_ProteinPupylation',s("The","process","in","which","a","Pup","protein","is","conjugated","to","a","target","protein","via","an","isopeptide","bond","between","the","carboxyl","terminus","of","Pup","and","the","epsilon-amino","group","of","a","lysine","residue","of","the","target","protein","."),4175754). assertion_content_comment('tOboGo_ProteinRefolding',s("The","process","carried","out","by","a","cell","that","restores","the","biological","activity","of","an","unfolded","or","misfolded","protein",",","using","helper","proteins","such","as","chaperones","."),4135180). assertion_content_comment('tOboGo_ProteinRepair',s("The","process","of","restoring","a","protein","to","its","original","state","after","damage","by","such","things","as","oxidation","or","spontaneous","decomposition","of","residues","."),4031634). assertion_content_comment('tOboGo_ProteinRetentionInERLumen',s("The","retention","in","the","endoplasmic","reticulum","(","ER",")","lumen","of","soluble","resident","proteins",".","Sorting","receptors","retrieve","proteins","with","ER","localization","signals",",","such","as","KDEL","and","HDEL","sequences","or","some","transmembrane","domains",",","that","have","escaped","to","the","cis-Golgi","network","and","return","them","to","the","ER",".","Abnormally","folded","proteins","and","unassembled","subunits","are","also","selectively","retained","in","the","ER","."),4230289). assertion_content_comment('tOboGo_ProteinRetentionInGolgiApparatus',s("The","retention","of","proteins","within","the","Golgi","apparatus",".","Golgi-localized","carbohydrate-modifying","enzymes","have","a","short","N-terminal","domain","that","faces","the","cytosol",",","a","single","transmembrane","alpha","helix",",","and","a","large","C-terminal","domain","that","faces","the","Golgi","lumen","and","that","contains","the","catalytic","site",".","How","the","membrane-spanning","alpha","helix","in","a","Golgi","enzyme","causes","its","localization","and","prevents","its","movement","to","the","plasma","membrane","is","not","known","."),4097112). assertion_content_comment('tOboGo_ProteinSecretionByPlatelet',s("The","regulated","release","of","proteins","by","a","platelet","or","group","of","platelets","."),4131057). assertion_content_comment('tOboGo_ProteinSecretionByTheTypeIIISecretionSystem',s("The","process","in","which","proteins","are","transferred","into","the","extracellular","milieu","or","directly","into","host","cells","by","the","bacterial","type","III","secretion","system",";","secretion","occurs","in","a","continuous","process","without","the","distinct","presence","of","periplasmic","intermediates","and","does","not","involve","proteolytic","processing","of","secreted","proteins","."),4311588). assertion_content_comment('tOboGo_ProteinSecretionByTheTypeIISecretionSystem',s("The","process","in","which","proteins","are","secreted","across","the","outer","membrane","of","Gram-negative","bacteria","by","the","type","II","secretion","system",".","Proteins","using","this","pathway","are","first","translocated","across","the","cytoplasmic","membrane","via","the","Sec","or","Tat","pathways","."),4290429). assertion_content_comment('tOboGo_ProteinSecretionByTheTypeISecretionSystem',s("The","process","in","which","proteins","are","secreted","into","the","extracellular","milieu","via","the","type","I","secretion","system",";","secretion","occurs","in","a","continuous","process","without","the","distinct","presence","of","periplasmic","intermediates","and","does","not","involve","proteolytic","processing","of","secreted","proteins","."),4311604). assertion_content_comment('tOboGo_ProteinSecretionByTheTypeIVSecretionSystem',s("The","process","in","which","proteins","are","transferred","into","the","extracellular","milieu","or","directly","into","host","cells",",","via","the","type","IV","protein","secretion","system","."),4311632). assertion_content_comment('tOboGo_ProteinSecretionByTheTypeVIISecretionSystem',s("The","process","in","which","proteins","are","transferred","into","the","extracellular","milieu","or","directly","into","host","cells",",","via","the","type","VII","protein","secretion","system","."),4287782). assertion_content_comment('tOboGo_ProteinSecretionByTheTypeVISecretionSystem',s("The","process","in","which","proteins","are","transferred","into","the","extracellular","milieu","or","directly","into","host","cells","by","the","type","VI","secretion","system",".","Proteins","secreted","by","this","system","do","not","require","an","N-terminal","signal","sequence","."),4347757). assertion_content_comment('tOboGo_ProteinSecretionByTheTypeVSecretionSystem',s("The","process","in","which","proteins","mediate","their","own","secretion","across","the","outer","membrane","through","a","beta-barrel","pore","structure","formed","by","the","C-terminal","domain","of","the","protein","precursor",".","Following","passage","across","the","outer","membrane",",","the","mature","protein","is","released","from","the","pore","by","an","autocatalytic","activity",".","Proteins","secreted","by","the","Type","V","system","are","first","translocated","across","the","plasma","membrane","by","the","Sec","pathway","."),4358043). assertion_content_comment('tOboGo_ProteinSecretion',s("The","controlled","release","of","proteins","from","a","cell","or","group","of","cells","."),3991474). assertion_content_comment('tOboGo_ProteinSerineThreonineKinaseActivatorActivity',s("Increases","the","activity","of","a","protein","serine/threonine","kinase","."),4305136). assertion_content_comment('tOboGo_ProteinSerineThreonineKinaseActivity',s("Catalysis","of","the","reactions",":","ATP","+","protein","serine","=","ADP","+","protein","serine","phosphate",",","and","ATP","+","protein","threonine","=","ADP","+","protein","threonine","phosphate","."),4157295). assertion_content_comment('tOboGo_ProteinSerineThreonineKinaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","protein","serine/threonine","kinase","."),4200316). assertion_content_comment('tOboGo_ProteinSerineThreoninePhosphataseActivity',s("Catalysis","of","the","reaction",":","protein","serine","phosphate","+","H2O","=","protein","serine","+","phosphate",",","and","protein","threonine","phosphate","+","H2O","=","protein","threonine","+","phosphate","."),4200977). assertion_content_comment('tOboGo_ProteinSerineThreoninePhosphataseComplex',s("A","complex",",","normally","consisting","of","a","catalytic","and","a","regulatory","subunit",",","which","catalyzes","the","removal","of","a","phosphate","group","from","a","serine","or","threonine","residue","of","a","protein","."),4129878). assertion_content_comment('tOboGo_ProteinSerineThreoninePhosphataseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","serine/threonine","protein","phosphatase",",","an","enzyme","that","catalyzes","the","reaction",":","protein","serine/threonine","phosphate","+","H2O","=","protein","serine/threonine","+","phosphate","."),4200378). assertion_content_comment('tOboGo_ProteinSerineThreonineTyrosineKinaseActivity',s("Catalysis","of","the","reactions",":","ATP","+","a","protein","serine","=","ADP","+","protein","serine","phosphate",";","ATP","+","a","protein","threonine","=","ADP","+","protein","threonine","phosphate",";","and","ATP","+","a","protein","tyrosine","=","ADP","+","protein","tyrosine","phosphate","."),4200509). assertion_content_comment('tOboGo_ProteinSideChainDeglutamylation',s("The","removal","of","a","glutamate","residue","from","the","side","chain","of","a","protein",".","Glutamate","side","chains","are","added","to","glutamic","acid","residues","within","the","primary","protein","sequence","during","polyglutamylation","."),4379927). assertion_content_comment('tOboGo_Protein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193416). assertion_content_comment('tOboGo_ProteinSplicing',s("The","post-translational","removal","of","peptide","sequences","from","within","a","protein","sequence","."),4042339). assertion_content_comment('tOboGo_ProteinStabilizationActivity',s("OBSOLETE",".","Strengthening","of","a","bond","between","proteins",".","Proteins","are","large","molecules","composed","of","one","or","more","chains","of","amino","acids",".","The","amino","acids","are","joined","in","a","specific","order","by","peptide","bonds","."),4268806). assertion_content_comment('tOboGo_ProteinStabilization',s("Any","process","involved","in","maintaining","the","structure","and","integrity","of","a","protein","and","preventing","it","from","degradation","or","aggregation","."),4268489). assertion_content_comment('tOboGo_ProteinStorageVacuoleLumen',s("The","volume","enclosed","by","the","protein","storage","vacuole","membrane","."),4074799). assertion_content_comment('tOboGo_ProteinStorageVacuoleMembrane',s("The","lipid","bilayer","surrounding","a","protein","storage","vacuole","."),4331742). assertion_content_comment('tOboGo_ProteinStorageVacuole',s("A","storage","vacuole","that","contains","a","lytic","vacuole",";","identified","in","plants","."),3974382). assertion_content_comment('tOboGo_ProteinSuccinylation',s("The","modification","of","a","protein","amino","acid","by","succinylation","."),4279703). assertion_content_comment('tOboGo_ProteinSulfation',s("The","addition","of","a","sulfate","group","as","an","ester","to","a","protein","amino","acid","."),4223904). assertion_content_comment('tOboGo_ProteinSumoylation',s("The","process","in","which","a","SUMO","protein","(","small","ubiquitin-related","modifier",")","is","conjugated","to","a","target","protein","via","an","isopeptide","bond","between","the","carboxyl","terminus","of","SUMO","with","an","epsilon-amino","group","of","a","lysine","residue","of","the","target","protein","."),4066520). assertion_content_comment('tOboGo_ProteinTaggingActivity',s("OBSOLETE",".","Covalent","addition","of","a","specific","tagging","molecule","to","a","protein",",","targeting","the","tagged","protein","for","some","fate","e.g",".","degradation","."),4253340). assertion_content_comment('tOboGo_ProteinTag',s("Acting","as","an","indicator","or","marker","to","facilitate","recognition","by","other","molecules","in","the","cell",".","Recognition","of","the","tag",",","which","can","be","covalently","attached","to","the","target","molecule",",","may","result","in","modification",",","sequestration",",","transport","or","degradation","of","the","molecule","in","question","."),4218208). assertion_content_comment('tOboGo_ProteinTargeting',s("The","process","of","targeting","specific","proteins","to","particular","membrane-bounded","subcellular","organelles",".","Usually","requires","an","organelle","specific","protein","sequence","motif","."),3970264). assertion_content_comment('tOboGo_ProteinTargetingToChloroplast',s("The","process","of","directing","proteins","towards","the","chloroplast",",","usually","using","signals","contained","within","the","protein",".","Imported","proteins","are","synthesized","as","cytosolic","precursors","containing","N-terminal","uptake-targeting","sequences","that","direct","each","protein","to","its","correct","subcompartment","and","are","subsequently","cleaved","."),4300870). assertion_content_comment('tOboGo_ProteinTargetingToER',s("The","process","of","directing","proteins","towards","the","endoplasmic","reticulum","(","ER",")","using","signals","contained","within","the","protein",".","One","common","mechanism","uses","a","16-","to","30-residue","signal","sequence",",","typically","located","at","the","N-terminus","of","the","protein","and","containing","positively","charged","amino","acids","followed","by","a","continuous","stretch","of","hydrophobic","residues",",","which","directs","the","ribosome","to","the","ER","membrane","and","initiates","transport","of","the","growing","polypeptide","across","the","ER","membrane","."),4013890). assertion_content_comment('tOboGo_ProteinTargetingToGolgi',s("The","process","of","directing","proteins","towards","the","Golgi",";","usually","uses","signals","contained","within","the","protein","."),4345625). assertion_content_comment('tOboGo_ProteinTargetingToLysosome',s("The","process","of","directing","proteins","towards","the","lysosome","using","signals","contained","within","the","protein","."),4034737). assertion_content_comment('tOboGo_ProteinTargetingToMembrane',s("The","process","of","directing","proteins","towards","a","membrane",",","usually","using","signals","contained","within","the","protein","."),4013847). assertion_content_comment('tOboGo_ProteinTargetingToMitochondrion',s("The","process","of","directing","proteins","towards","and","into","the","mitochondrion",",","usually","mediated","by","mitochondrial","proteins","that","recognize","signals","contained","within","the","imported","protein","."),4013796). assertion_content_comment('tOboGo_ProteinTargetingToPeroxisome',s("The","process","of","directing","proteins","towards","the","peroxisome",",","usually","using","signals","contained","within","the","protein","."),4040618). assertion_content_comment('tOboGo_ProteinTargetingToPlasmaMembrane',s("The","process","of","directing","proteins","towards","the","plasma","membrane",";","usually","uses","signals","contained","within","the","protein","."),4158061). assertion_content_comment('tOboGo_ProteinTargetingToVacuoleInvolvedInAutophagy',s("The","process","of","directing","proteins","towards","the","vacuole","using","signals","contained","within","the","protein",",","occurring","as","part","of","autophagy",",","the","process","in","which","cells","digest","parts","of","their","own","cytoplasm","."),4128866). assertion_content_comment('tOboGo_ProteinTargetingToVacuole',s("The","process","of","directing","proteins","towards","the","vacuole",",","usually","using","signals","contained","within","the","protein","."),4034721). assertion_content_comment('tOboGo_ProteinTetramerizationActivity',s("OBSOLETE",".","The","formation","of","a","protein","tetramer",",","a","macromolecular","structure","consisting","of","four","noncovalently","associated","identical","or","nonidentical","subunits","."),4287041). assertion_content_comment('tOboGo_ProteinTetramerization',s("The","formation","of","a","protein","tetramer",",","a","macromolecular","structure","consisting","of","four","noncovalently","associated","identical","or","nonidentical","subunits","."),4285796). assertion_content_comment('tOboGo_ProteinToMembraneDocking',s("The","initial","attachment","of","a","protein","to","a","target","membrane",",","mediated","by","a","proteins","protruding","from","the","target","membrane",".","Docking","requires","only","that","the","proteins","come","close","enough","to","interact","and","adhere","."),4013914). assertion_content_comment('tOboGo_ProteinTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","protein","from","one","side","of","a","membrane","to","the","other","."),4234260). assertion_content_comment('tOboGo_ProteinTransmembraneTransport',s("The","directed","movement","of","a","protein","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4014002). assertion_content_comment('tOboGo_ProteinTransportAcrossPeriplasmicSpace',s("The","directed","movement","of","proteins","from","the","plasma","membrane","across","the","periplasmic","space","to","the","outer","membrane","or","cell","wall","."),4158729). assertion_content_comment('tOboGo_ProteinTransportByTheSecComplex',s("The","process","in","which","unfolded","proteins","are","transported","across","the","cytoplasmic","membrane","in","Gram-positive","and","Gram-negative","bacteria","by","the","Sec","complex",",","in","a","process","involving","proteolytic","cleavage","of","an","N-terminal","signal","peptide","."),4328093). assertion_content_comment('tOboGo_ProteinTransportByTheTatComplex',s("The","process","in","which","folded","proteins","are","transported","across","cytoplasmic","membranes","of","bacteria","and","membranes","of","organelles","derived","from","bacteria","(","chloroplasts","and","mitochondria",")","by","the","TAT","complex","."),4328080). assertion_content_comment('tOboGo_ProteinTransporterActivity',s("Enables","the","directed","movement","of","proteins","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4234242). assertion_content_comment('tOboGo_ProteinTransportIntoMembraneRaft',s("The","directed","movement","of","a","protein","into","a","membrane","raft","."),4331669). assertion_content_comment('tOboGo_ProteinTransportOutOfMembraneRaft',s("The","directed","movement","of","a","protein","out","of","a","membrane","raft","."),4331708). assertion_content_comment('tOboGo_ProteinTransport',s("The","directed","movement","of","proteins","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3970233). assertion_content_comment('tOboGo_ProteinTransportWithinExtracellularRegion',s("The","directed","movement","of","proteins","in","the","extracellular","region",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4172424). assertion_content_comment('tOboGo_ProteinTransportWithinLipidBilayer',s("The","directed","movement","of","a","protein","from","one","location","to","another","within","a","lipid","bilayer","."),4331645). assertion_content_comment('tOboGo_ProteinTrimerization',s("The","formation","of","a","protein","trimer",",","a","macromolecular","structure","consisting","of","three","noncovalently","associated","identical","or","nonidentical","subunits","."),4173713). assertion_content_comment('tOboGo_ProteinTyrosineKinaseActivatorActivity',s("Increases","the","activity","of","a","protein","tyrosine","kinase",",","an","enzyme","which","phosphorylates","a","tyrosyl","phenolic","group","on","a","protein","."),4217305). assertion_content_comment('tOboGo_ProteinTyrosineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","a","protein","tyrosine","=","ADP","+","protein","tyrosine","phosphate","."),4159700). assertion_content_comment('tOboGo_ProteinTyrosineKinaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","protein","tyrosine","kinase","."),4217403). assertion_content_comment('tOboGo_ProteinTyrosinePhosphataseActivatorActivity',s("Increases","the","activity","of","a","phosphatase",",","an","enzyme","which","catalyzes","of","the","removal","of","a","phosphate","group","from","a","tyrosyl","phenolic","group","of","a","protein","."),4245938). assertion_content_comment('tOboGo_ProteinTyrosinePhosphataseActivity',s("Catalysis","of","the","reaction",":","protein","tyrosine","phosphate","+","H2O","=","protein","tyrosine","+","phosphate","."),4200889). assertion_content_comment('tOboGo_ProteinTyrosineSerineThreoninePhosphataseActivity',s("Catalysis","of","the","reactions",":","protein","serine","+","H2O","=","protein","serine","+","phosphate",";","protein","threonine","phosphate","+","H2O","=","protein","threonine","+","phosphate",";","and","protein","tyrosine","phosphate","+","H2O","=","protein","tyrosine","+","phosphate","."),4246530). assertion_content_comment('tOboGo_ProteinTyrosineThreoninePhosphataseActivity',s("Catalysis","of","the","reactions",":","protein","threonine","phosphate","+","H2O","=","protein","threonine","+","phosphate",";","and","protein","tyrosine","phosphate","+","H2O","=","protein","tyrosine","+","phosphate","."),4255306). assertion_content_comment('tOboGo_ProteinTyrosinylation',s("The","addition","of","a","tyrosine","molecule","to","a","protein","amino","acid","."),4279566). assertion_content_comment('tOboGo_ProteinUbiquitination',s("The","process","in","which","one","or","more","ubiquitin","groups","are","added","to","a","protein","."),4012322). assertion_content_comment('tOboGo_ProteinUfmylation',s("Covalent","attachment","of","the","ubiquitin-like","protein","UFM1","to","another","protein","."),4171218). assertion_content_comment('tOboGo_ProteinUnfolding',s("The","process","of","assisting","in","the","disassembly","of","non-covalent","linkages","in","a","protein","or","protein","aggregate",",","often","where","the","proteins","are","in","a","non-functional","or","denatured","state","."),4318240). assertion_content_comment('tOboGo_ProteinUridylylation',s("The","addition","of","phospho-uridine","to","a","protein","amino","acid","."),4284413). assertion_content_comment('tOboGo_ProteinUrmylation',s("Covalent","attachment","of","the","ubiquitin-like","protein","URM1","to","another","protein","."),4334709). assertion_content_comment('tOboGo_ProteinXylosyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","beta-D-xylosyl","residue","from","UDP-D-xylose","to","the","serine","hydroxyl","group","of","an","acceptor","protein","substrate","."),4311288). assertion_content_comment('tOboGo_ProteoglycanBinding',s("Interacting","selectively","and","non-covalently","with","a","proteoglycan",",","any","glycoprotein","in","which","the","carbohydrate","units","are","glycosaminoglycans","."),4318183). assertion_content_comment('tOboGo_ProteoglycanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","proteoglycans",",","any","glycoprotein","in","which","the","carbohydrate","units","are","glycosaminoglycans","."),4038226). assertion_content_comment('tOboGo_ProteoglycanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","proteoglycans",",","any","glycoprotein","in","which","the","carbohydrate","units","are","glycosaminoglycans","."),4311223). assertion_content_comment('tOboGo_ProteoglycanIntegralToPlasmaMembrane',s("OBSOLETE",".","Penetrating","at","least","one","phospholipid","bilayer","of","a","plasma","membrane","and","consisting","of","proteoglycan",".","Also","refers","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4221520). assertion_content_comment('tOboGo_ProteoglycanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","proteoglycans",",","any","glycoprotein","in","which","the","carbohydrate","units","are","glycosaminoglycans","."),4038221). assertion_content_comment('tOboGo_Proteoglycan',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217730). assertion_content_comment('tOboGo_ProteoglycanSulfateTransfer',s("OBSOLETE",".","Transfer","of","sulfate","to","a","proteoglycan","(","a","glycoprotein","whose","carbohydrate","units","are","glycosaminoglycans",")","using","3","'","-phosphoadenyl","sulfate","."),4361684). assertion_content_comment('tOboGo_ProteoglycanSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","proteoglycan","=","adenosine","3","'",",","5","'","-bisphosphate","+","proteoglycan","sulfate",".","A","proteoglycan","is","a","glycoprotein","whose","carbohydrate","units","are","glycosaminoglycans","."),4277021). assertion_content_comment('tOboGo_ProteolysisAssociatedWithAntigenProcessingAndPresentation',s("The","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","contributing","to","antigen","processing","and","presentation","."),3993901). assertion_content_comment('tOboGo_ProteolysisByCytosolicProteasesAssociatedWithAntigenProcessingAndPresentation',s("The","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","by","cytosolic","resident","proteases","during","antigen","processing","and","presentation","."),4377188). assertion_content_comment('tOboGo_ProteolysisInvolvedInCellularProteinCatabolicProcess',s("The","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","as","part","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","by","individual","cells","."),3990248). assertion_content_comment('tOboGo_Proteolysis',s("The","hydrolysis","of","proteins","into","smaller","polypeptides","and/or","amino","acids","by","cleavage","of","their","peptide","bonds","."),3986181). assertion_content_comment('tOboGo_ProteolysisWithinEndoplasmicReticulumAssociatedWithAntigenProcessingAndPresentation',s("The","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","by","ER","resident","proteases","contributing","to","antigen","processing","and","presentation","."),4380611). assertion_content_comment('tOboGo_ProteolysisWithinEndosomeAssociatedWithAntigenProcessingAndPresentation',s("The","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","by","endosomal","resident","proteases","contributing","to","antigen","processing","and","presentation","."),4380623). assertion_content_comment('tOboGo_ProteolysisWithinLysosomeAssociatedWithAntigenProcessingAndPresentation',s("The","hydrolysis","of","a","peptide","bond","or","bonds","within","a","protein","by","lysosomal","resident","proteases","contributing","to","antigen","processing","and","presentation","."),4381619). assertion_content_comment('tOboGo_ProthoracicDiscDevelopment',s("Progression","of","the","prothoracic","disc","over","time",",","from","its","initial","formation","through","to","its","metamorphosis","to","form","the","adult","humerous","and","anterior","spiracle","."),4018001). assertion_content_comment('tOboGo_ProthoracicDiscMorphogenesis',s("The","process","in","which","the","anatomical","structures","derived","from","the","prothoracic","disc","are","generated","and","organized",".","This","includes","the","transformation","of","a","prothoracic","imaginal","disc","from","a","monolayered","epithelium","in","the","larvae","of","holometabolous","insects","into","the","recognizable","adult","humerous","and","anterior","spiracle","."),4018012). assertion_content_comment('tOboGo_ProthoracicMorphogenesis',s("OBSOLETE",".","The","process","by","which","the","anatomical","structures","of","the","first","or","anterior","segment","of","the","insect","thorax","are","generated","and","organized","."),4234374). assertion_content_comment('tOboGo_ProthoracicotrophicHormoneActivity',s("The","action","characteristic","of","prothoracicotrophic","hormone",",","a","peptide","hormone","that","is","secreted","by","the","brain","and",",","upon","receptor","binding",",","acts","on","the","prothoracic","gland","to","stimulate","the","release","of","ecdysone","in","insects","."),4281615). assertion_content_comment('tOboGo_ProthylakoidMembrane',s("The","membrane","of","prothylakoids",",","underdeveloped","thylakoids","found","in","etioplasts",",","lacking","competent","photosynthetic","membranes","."),4077717). assertion_content_comment('tOboGo_Prothylakoid',s("Underdeveloped","thylakoids","found","in","etioplasts",",","lacking","competent","photosynthetic","membranes",".","Rapidly","develop","into","mature","thylakoids","in","the","presence","of","light","."),4077707). assertion_content_comment('tOboGo_ProtocatechuateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","protocatechuate",",","the","anion","of","3",",","4-dihydroxybenzoic","acid","."),4353356). assertion_content_comment('tOboGo_ProtocatechuateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","protocatechuate",",","the","anion","of","3",",","4-dihydroxybenzoic","acid","."),4243733). assertion_content_comment('tOboGo_ProtocatechuateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydroxybenzoate","+","H","(","+",")","=","catechol","+","CO","(","2",")"),4263450). assertion_content_comment('tOboGo_ProtocatechuateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","protocatechuate",",","the","anion","of","protocatechuic","acid","(","3",",","4-dihydroxybenzoic","acid",")"),4243728). assertion_content_comment('tOboGo_ProtochlorophyllideReductaseActivity',s("Catalysis","of","the","reaction",":","chlorophyllide","a","+","NADP","+","=","protochlorophyllide","+","NADPH","+","H","+"),4305806). assertion_content_comment('tOboGo_ProtodermHistogenesis',s("The","formation","of","the","primary","meristem","or","meristematic","tissue","that","gives","rise","to","the","epidermis","."),4329634). assertion_content_comment('tOboGo_ProtohemeIXFarnesyltransferaseActivity',s("Catalysis","of","the","reaction",":","protoheme","IX","+","(","2E",",","6E",")","-farnesyl","diphosphate","+","H2O","=","heme","o","+","diphosphate","."),4254460). assertion_content_comment('tOboGo_ProtonMotiveForceDependentProteinTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","proteins","from","one","side","of","the","membrane","to","the","other",".","Transportation","is","dependent","on","pH","gradient","across","the","membrane","."),4262036). assertion_content_comment('tOboGo_ProtonTransport',s("The","directed","movement","of","protons","(","hydrogen","ions",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4031684). assertion_content_comment('tOboGo_ProtoporphyrinogenIXBiosyntheticProcessFromGlutamate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","protoporphyrinogen","IX","from","other","compounds",",","including","glutamate","."),4239594). assertion_content_comment('tOboGo_ProtoporphyrinogenIXBiosyntheticProcessFromGlycine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","protoporphyrinogen","IX","from","other","compounds",",","including","glycine","."),4239639). assertion_content_comment('tOboGo_ProtoporphyrinogenIXBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","protoporphyrinogen","IX","."),4014554). assertion_content_comment('tOboGo_ProtoporphyrinogenIXMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","protoporphyrinogen","IX",",","the","specific","substrate","for","the","enzyme","ferrochelatase",",","which","catalyzes","the","insertion","of","iron","to","form","protoheme",".","It","is","probably","also","the","substrate","for","chlorophyll","formation","."),4014550). assertion_content_comment('tOboGo_ProtoporphyrinogenOxidaseActivity',s("Catalysis","of","the","reaction",":","protoporphyrinogen-IX","+","acceptor","=","protoporphyrin-IX","+","reduced","acceptor","."),4178970). assertion_content_comment('tOboGo_ProtoxylemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","protoxylem","over","time",",","from","its","formation","to","the","mature","structure",".","The","protoxylem","comprises","the","first","formed","elements","of","the","primary","xylem","."),4150072). assertion_content_comment('tOboGo_ProvirusExcision',s("The","molecular","events","that","lead","to","the","excision","of","a","viral","genome","from","the","host","genome","."),4333717). assertion_content_comment('tOboGo_ProvirusIntegration',s("The","molecular","events","that","lead","to","the","integration","of","a","viral","genome","into","the","host","genome","."),4045158). assertion_content_comment('tOboGo_ProvirusMaintenance',s("The","molecular","events","that","maintain","a","viral","genome","integrated","into","a","host","genome","."),4056651). assertion_content_comment('tOboGo_Provirus',s("The","name","given","to","a","viral","genome","after","it","has","been","integrated","into","the","host","genome",";","particularly","applies","to","retroviruses","and","is","a","required","part","of","the","retroviral","replication","cycle","."),4236946). assertion_content_comment('tOboGo_ProximalConvolutedTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","proximal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","proximal","convoluted","tubule","is","the","most","proximal","portion","of","the","proximal","tubule","and","extends","from","the","glomerular","capsule","to","the","proximal","straight","tubule","."),4123027). assertion_content_comment('tOboGo_ProximalDistalAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","proximal/distal","axis",".","The","proximal/distal","axis","is","defined","by","a","line","that","runs","from","main","body","(","proximal","end",")","of","an","organism","outward","(","distal","end",")"),4032244). assertion_content_comment('tOboGo_ProximalDistalPatternFormationImaginalDisc',s("The","establishment",",","maintenance","and","elaboration","of","the","proximal/distal","axis","of","the","imaginal","disc",".","Imaginal","disks","are","masses","of","hypodermic","cells",",","carried","by","the","larvae","of","some","insects","after","leaving","the","egg",",","from","which","masses","the","wings","and","legs","of","the","adult","are","subsequently","formed","."),4234391). assertion_content_comment('tOboGo_ProximalDistalPatternFormationInvolvedInMesonephricNephronDevelopment',s("The","regionalization","process","in","which","specific","areas","of","cell","differentiation","are","determined","along","a","proximal/distal","axis","of","a","nephron","in","the","mesonephros",".","The","proximal/distal","axis","is","defined","by","a","line","that","runs","from","the","glomerulus","(","proximal","end",")","outward","toward","the","mesonephric","duct","(","distal","end",")"),4133925). assertion_content_comment('tOboGo_ProximalDistalPatternFormationInvolvedInMetanephricNephronDevelopment',s("The","regionalization","process","in","which","specific","areas","of","cell","differentiation","are","determined","along","a","proximal/distal","axis","of","a","nephron","in","the","metanephros",".","The","proximal/distal","axis","is","defined","by","a","line","that","runs","from","the","center","of","the","kidney","(","proximal","end",")","outward","(","distal","end",")"),4124471). assertion_content_comment('tOboGo_ProximalDistalPatternFormationInvolvedInNephronDevelopment',s("The","regionalization","process","in","which","specific","areas","of","cell","differentiation","are","determined","along","a","proximal/distal","axis","of","a","nephron",".","The","proximal/distal","axis","is","defined","by","a","line","that","runs","from","the","center","of","the","kidney","(","proximal","end",")","outward","(","distal","end",")"),4059069). assertion_content_comment('tOboGo_ProximalDistalPatternFormationInvolvedInPronephricNephronDevelopment',s("The","regionalization","process","in","which","specific","areas","of","cell","differentiation","are","determined","along","a","proximal/distal","axis","of","the","pronephros","."),4059109). assertion_content_comment('tOboGo_ProximalDistalPatternFormation',s("The","regionalization","process","in","which","specific","areas","of","cell","differentiation","are","determined","along","a","proximal/distal","axis",".","The","proximal/distal","axis","is","defined","by","a","line","that","runs","from","main","body","(","proximal","end",")","of","an","organism","outward","(","distal","end",")"),4032241). assertion_content_comment('tOboGo_ProximalStomachSmoothMuscleContraction',s("A","process","in","which","force","is","generated","within","smooth","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","This","process","occurs","in","the","proximal","stomach",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","proximal","stomach",",","composed","of","the","fundus","and","upper","body",",","shows","low","frequency",",","sustained","tonic","contractions","that","are","responsible","for","generating","a","basal","pressure","within","the","stomach","."),4321198). assertion_content_comment('tOboGo_ProximalStraightTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","proximal","straight","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","proximal","straight","tubule","is","the","part","of","the","descending","limb","that","extends","from","the","proximal","convoluted","tubule","to","the","descending","thin","tubule","."),4125114). assertion_content_comment('tOboGo_ProximalTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","proximal","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","In","mammals",",","the","proximal","tubule","is","a","nephron","tubule","that","connects","Bowman","'","s","capsule","to","the","descending","thin","limb","of","the","loop","of","Henle",".","It","has","a","brush","border","epithelial","morphology","."),4059138). assertion_content_comment('tOboGo_ProximalTubuleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","proximal","tubule","are","generated","and","organized",".","The","proximal","tubule","is","a","nephron","tubule","that","connects","Bowman","'","s","capsule","to","the","descending","thin","limb","of","the","loop","of","Henle",".","It","has","a","brush","border","epithelial","morphology","."),4059140). assertion_content_comment('tOboGo_Prp19Complex',s("A","protein","complex","consisting","of","Prp19","and","associated","proteins","that","is","involved","in","the","transition","from","the","precatalytic","spliceosome","to","the","activated","form","that","catalyzes","step","1","of","splicing",",","and","which","remains","associated","with","the","spliceosome","through","the","second","catalytic","step",".","It","is","widely","conserved",",","found","in","both","yeast","and","mammals",",","though","the","exact","composition","varies",".","In","S",".","cerevisiae",",","it","contains","Prp19p",",","Ntc20p",",","Snt309p",",","Isy1p",",","Syf2p",",","Cwc2p",",","Prp46p",",","Clf1p",",","Cef1p",",","and","Syf1p","."),4363292). assertion_content_comment('tOboGo_PseudocleavageInvolvedInSyncytialBlastodermFormation',s("Formation","of","furrows","in","the","cytoplasm","between","nuclei","during","cell","cycles","in","embryos","that","contribute","to","the","formation","of","the","syncytial","blastoderm",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4051792). assertion_content_comment('tOboGo_Pseudocleavage',s("Partial","constriction","of","the","cytoplasm","of","an","embryo","to","form","a","furrow","that","resembles","a","cleavage","furrow","but","does","not","complete","cytokinesis","."),4051782). assertion_content_comment('tOboGo_PseudohyphalGrowth',s("A","pattern","of","cell","growth","that","occurs","in","conditions","of","nitrogen","limitation","and","abundant","fermentable","carbon","source",".","Cells","become","elongated",",","switch","to","a","unipolar","budding","pattern",",","remain","physically","attached","to","each","other",",","and","invade","the","growth","substrate","."),4140797). assertion_content_comment('tOboGo_PseudohyphalSeptinRing',s("A","tight","ring-shaped","structure","that","forms","in","the","division","plane","at","the","junction","between","the","mother","cell","and","a","pseudohyphal","projection",";","composed","of","septins","as","well","as","septin-associated","proteins","."),4329569). assertion_content_comment('tOboGo_PseudophosphataseActivity',s("Maintains","the","phosphorylation","state","of","certain","molecules","by","associating","with","them","and","preventing","them","from","associating","with","active","phosphatases",",","and","thus","inhibiting","the","enzyme","activity","without","interacting","with","the","enzyme",".","Often","pertains","to","proteins","belonging","to","dual-specificity","phosphatase","family","but","lacking","critical","active","site","residues","."),4383843). assertion_content_comment('tOboGo_PseudopodiumAssembly',s("The","assembly","of","a","pseudopodium","by","rearrangement","of","the","actin","cytoskeleton","and","overlying","membrane","."),4049759). assertion_content_comment('tOboGo_PseudopodiumMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","pseudopodium","."),4062326). assertion_content_comment('tOboGo_PseudopodiumOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","pseudopodium",",","a","temporary","protrusion","or","retractile","process","of","a","cell",",","associated","with","cellular","movement","."),4049755). assertion_content_comment('tOboGo_PseudopodiumRetraction',s("The","myosin-based","contraction","and","retraction","of","the","pseudopodium","."),4320159). assertion_content_comment('tOboGo_Pseudopodium',s("A","temporary","protrusion","or","retractile","process","of","a","cell",",","associated","with","flowing","movements","of","the","protoplasm",",","and","serving","for","locomotion","and","feeding","."),4062315). assertion_content_comment('tOboGo_PseudouridineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","pseudouridine","=","ADP","+","2","H","(","+",")","+","pseudouridine","5","'","-phosphate","."),4263427). assertion_content_comment('tOboGo_PseudouridineSynthaseActivity',s("Catalysis","of","the","reaction",":","RNA","uridine","=","RNA","pseudouridine",".","Conversion","of","uridine","in","an","RNA","molecule","to","pseudouridine","by","rotation","of","the","C1","'","-N-1","glycosidic","bond","of","uridine","in","RNA","to","a","C1","'","-C5","."),4261947). assertion_content_comment('tOboGo_PseudouridineSynthesis',s("The","intramolecular","conversion","of","uridine","to","pseudouridine","within","an","RNA","molecule",".","This","posttranscriptional","base","modification","occurs","in","tRNA",",","rRNA",",","and","snRNAs","."),4178102). assertion_content_comment('tOboGo_PseudouridylateSynthaseActivity',s("Catalysis","of","the","reaction",":","D-ribose","5-phosphate","+","uracil","=","H","(","2",")","O","+","pseudouridine","5","'","-phosphate","."),4200776). assertion_content_comment('tOboGo_PsychosineSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","galactosylsphingosine","=","adenosine","3","'",",","5","'","-bisphosphate","+","psychosine","sulfate","."),4263413). assertion_content_comment('tOboGo_PTBDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","phosphotyrosine-binding","(","PTB",")","domain","of","a","protein","."),4286697). assertion_content_comment('tOboGo_PteridineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pteridine",",","pyrazino","(","2",",","3-dipyrimidine",")",",","the","parent","structure","of","pterins","and","the","pteroyl","group","."),4229497). assertion_content_comment('tOboGo_PteridineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pteridine",",","pyrazino","(","2",",","3-dipyrimidine",")",",","the","parent","structure","of","pterins","and","the","pteroyl","group","."),4233202). assertion_content_comment('tOboGo_PteridineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pteridine",",","pyrazino","(","2",",","3-dipyrimidine",")",",","the","parent","structure","of","pterins","and","the","pteroyl","group","."),4080148). assertion_content_comment('tOboGo_PteridineOxidaseActivity',s("Catalysis","of","the","reaction",":","2-amino-4-hydroxypteridine","+","O2","=","2-amino-4",",","7-dihydroxypteridine","+","unknown","."),4263403). assertion_content_comment('tOboGo_PteridineReductaseActivity',s("Catalysis","of","the","reaction",":","5",",","6",",","7",",","8-tetrahydrobiopterin","+","2","NADP","(","+",")","=","biopterin","+","2","H","(","+",")","+","2","NADPH","."),4228372). assertion_content_comment('tOboGo_PterinDeaminaseActivity',s("Catalysis","of","the","reaction",":","2-amino-4-hydroxypteridine","+","H2O","=","2",",","4-dihydroxypteridine","+","NH3","."),4263392). assertion_content_comment('tOboGo_Pterinosome',s("A","tissue-specific",",","membrane-bounded","cytoplasmic","organelle","within","which","pteridine","pigments","are","synthesized","and","stored",".","Pterinosomes","are","synthesized","in","xanthophores","and","erythrophore","cells","and","are","yellow",",","orange","or","red","in","appearance","."),4326228). assertion_content_comment('tOboGo_PterocarpinSynthaseActivity',s("Catalysis","of","the","reaction",":","medicarpin","+","NADP","+","=","vestitone","+","NADPH","."),4263380). assertion_content_comment('tOboGo_PTWPP1PhosphataseComplex',s("A","protein","serine/threonine","phosphatase","complex","that","contains","a","catalytic","subunits","(","PPP1CA",",","PPP1CB","or","PPP1CC",")","and","the","regulatory","subunits","PPP1R10","(","PNUTS",")",",","TOX4","and","WDR82",",","and","plays","a","role","in","the","control","of","chromatin","structure","and","cell","cycle","progression","during","the","transition","from","mitosis","into","interphase","."),4159029). assertion_content_comment('tOboGo_PullulanaseActivity',s("Catalysis","of","the","hydrolysis","of","(","1",",","6",")","-a-D-glucosidic","linkages","in","pullulan","[","a","linear","polymer","of","a-","(","1",",","6",")","-linked","maltotriose","units","]","and","in","amylopectin","and","glycogen",",","and","the","a-","and","b-limit","dextrins","of","amylopectin","and","glycogen","."),4286983). assertion_content_comment('tOboGo_PullulanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pullulan",",","a","neutral","linear","polysaccharide","composed","of","repeating","units","of","maltotriose","joined","by","alpha-","(","1",",","6",")","-linkages","."),4285516). assertion_content_comment('tOboGo_PullulanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pullulan",",","a","neutral","linear","polysaccharide","composed","of","repeating","units","of","maltotriose","joined","by","alpha-","(","1",",","6",")","-linkages","."),4285506). assertion_content_comment('tOboGo_PullulanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pullulan",",","a","neutral","linear","polysaccharide","composed","of","repeating","units","of","maltotriose","joined","by","alpha-","(","1",",","6",")","-linkages","."),4285503). assertion_content_comment('tOboGo_PulmonaryArteryEndothelialTubeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","tube","are","generated","and","organized","from","the","pulmonary","artery","endothelium",".","An","pulmonary","artery","endothelium","is","an","epithelium","that","lines","the","pulmonary","artery","."),4135844). assertion_content_comment('tOboGo_PulmonaryArteryMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","pulmonary","artery","are","generated","and","organized",".","The","pulmonary","artery","is","the","artery","that","carries","blood","from","the","heart","to","the","lungs","."),4135834). assertion_content_comment('tOboGo_PulmonaryMyocardiumDevelopment',s("The","progression","of","the","pulmonary","myocardium","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","pulmonary","myocardium","is","the","myocardial","tissue","present","in","the","pulmonary","vein","."),4005939). assertion_content_comment('tOboGo_PulmonaryValveDevelopment',s("The","progression","of","the","pulmonary","valve","over","time",",","from","its","formation","to","the","mature","structure","."),4002305). assertion_content_comment('tOboGo_PulmonaryValveFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","pulmonary","valve","from","unspecified","parts",".","This","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","discrete","structure","and","ends","when","the","structural","rudiment","is","recognizable","."),4002407). assertion_content_comment('tOboGo_PulmonaryValveMorphogenesis',s("The","process","in","which","the","structure","of","the","pulmonary","valve","is","generated","and","organized","."),4002315). assertion_content_comment('tOboGo_PulmonaryVeinMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","pulmonary","venous","blood","vessels","are","generated","and","organized",".","Pulmonary","veins","are","blood","vessels","that","transport","blood","from","the","lungs","to","the","heart","."),4160834). assertion_content_comment('tOboGo_PunctaAdhaerentia',s("A","small","version","of","the","zonula","adherens","type","junction",",","characterized","by","a","symmetrical","adherent","point","between","two","cells","."),4288178). assertion_content_comment('tOboGo_PupalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","pupa","over","time",",","from","its","formation","to","the","mature","structure",".","The","pupa","is","a","dormant","life","stage","interposed","between","the","larval","and","the","adult","stages","in","insects","that","undergo","a","complete","metamorphosis","."),4020694). assertion_content_comment('tOboGo_PuparialAdhesion',s("The","adhesion","of","the","puparia","of","Diptera","to","their","substrate",";","normally","effected","by","a","'","glue","'","secreted","by","the","larval","salivary","gland","and","expectorated","at","the","time","of","pupariation","."),4015309). assertion_content_comment('tOboGo_PuparialGlueSensuDiptera',s("OBSOLETE",".","A","glue","which","attaches","the","pupae","to","the","substrate","during","metamorphosis",",","as","in",",","but","not","restricted","to",",","the","true","flies","(","Diptera",",","ncbi_taxonomy_id",":","7147",")"),4245766). assertion_content_comment('tOboGo_Pupariation',s("The","onset","of","prepupal","development","when","the","larval","stops","crawling",",","everts","its","spiracles","and","the","larval","cuticle","becomes","the","puparium","or","pupal","case","that","surrounds","the","organism","for","the","duration","of","metamorphosis","."),4072935). assertion_content_comment('tOboGo_Pupation',s("The","act","of","becoming","a","pupa",",","a","resting","stage","in","the","life","cycle","of","organisms","with","complete","metamorphosis",".","This","event","marks","the","end","of","the","prepupal","period","and","the","beginning","of","the","pupal","period","."),4072913). assertion_content_comment('tOboGo_PupLigaseActivity',s("Catalysis","of","ATP-dependent","isopeptide","bond","formation","between","the","carboxy-terminal","residue","of","the","small","ubiquitin-related","modifier","Pup","and","a","substrate","lysine","residue","."),4156621). assertion_content_comment('tOboGo_PurineAlkaloidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","alkaloids",",","compounds","derived","from","purine","and","composed","of","an","N-containing","double","ring","structure","."),4260691). assertion_content_comment('tOboGo_PurineAlkaloidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","alkaloids",",","compounds","derived","from","purine","and","composed","of","an","N-containing","double","ring","structure","."),4260687). assertion_content_comment('tOboGo_PurineBaseBinding',s("Interacting","selectively","and","non-covalently","with","a","purine","base",",","an","organic","nitrogenous","base","with","a","purine","skeleton","."),4373647). assertion_content_comment('tOboGo_PurineBaseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","bases",",","one","of","the","two","classes","of","nitrogen-containing","ring","compounds","found","in","DNA","and","RNA",",","which","include","adenine","and","guanine","."),4227582). assertion_content_comment('tOboGo_PurineBaseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","bases",",","one","of","the","two","classes","of","nitrogen-containing","ring","compounds","found","in","DNA","and","RNA",",","which","include","adenine","and","guanine","."),4227956). assertion_content_comment('tOboGo_PurineBaseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","bases",",","one","of","the","two","classes","of","nitrogen-containing","ring","compounds","found","in","DNA","and","RNA",",","which","include","adenine","and","guanine","."),4010759). assertion_content_comment('tOboGo_PurineBaseSalvage',s("Any","process","that","generates","purine","bases",",","one","of","the","two","classes","of","nitrogen-containing","ring","compounds","found","in","DNA","and","RNA",",","from","derivatives","of","them","without","de","novo","synthesis","."),4227590). assertion_content_comment('tOboGo_PurineBaseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","purine","bases",",","one","of","the","two","classes","of","nitrogen-containing","ring","compounds","found","in","DNA","and","RNA",",","from","one","side","of","a","membrane","to","the","other","."),4216372). assertion_content_comment('tOboGo_PurineBaseTransport',s("The","directed","movement","of","purine","bases",",","one","of","the","two","classes","of","nitrogen-containing","ring","compounds","found","in","DNA","and","RNA",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083474). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideBinding',s("Interacting","selectively","and","non-covalently","with","a","purine","deoxyribonucleoside",",","a","compound","consisting","of","a","purine","base","linked","to","deoxyribose","."),4331339). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","purine","deoxyribonucleoside",",","one","of","a","family","of","organic","molecules","consisting","of","a","purine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4227233). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","one","of","a","family","of","organic","molecules","consisting","of","a","purine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4227684). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","deoxyribonucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4227134). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","deoxyribonucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4258471). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","deoxyribonucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4226988). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","purine","deoxyribonucleoside","is","synthesized","from","another","purine","deoxyribonucleoside","."),4244628). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","one","of","a","family","of","organic","molecules","consisting","of","a","purine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4227230). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","deoxyribonucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4227275). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideMonophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","deoxyribonucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4258503). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideMonophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","deoxyribonucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4227272). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideSalvage',s("Any","process","which","produces","a","purine","deoxyribonucleoside","from","derivatives","of","it",",","without","de","novo","synthesis","."),4227239). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4227046). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4226835). assertion_content_comment('tOboGo_PurineDeoxyribonucleosideTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4226832). assertion_content_comment('tOboGo_PurineDeoxyribonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","purine","deoxyribonucleotide",",","any","compound","consisting","of","a","purine","deoxyribonucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","deoxyribose","moiety","."),4331308). assertion_content_comment('tOboGo_PurineDeoxyribonucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","deoxyribonucleotide",",","a","compound","consisting","of","deoxyribonucleoside","(","a","purine","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4227038). assertion_content_comment('tOboGo_PurineDeoxyribonucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","deoxyribonucleotide",",","a","compound","consisting","of","deoxyribonucleoside","(","a","purine","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4226815). assertion_content_comment('tOboGo_PurineDeoxyribonucleotideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","purine","deoxyribonucleotide","is","synthesized","from","another","purine","deoxyribonucleotide","."),4294698). assertion_content_comment('tOboGo_PurineDeoxyribonucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","deoxyribonucleotide",",","a","compound","consisting","of","deoxyribonucleoside","(","a","purine","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4226811). assertion_content_comment('tOboGo_PurineDeoxyribosyltransferaseActivity',s("Catalysis","of","deoxyribose","exchange","between","purine","deoxyribonucleoside","as","a","donor","and","purine","base","as","an","acceptor","."),4288442). assertion_content_comment('tOboGo_PurineMetabolicProcess',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4227993). assertion_content_comment('tOboGo_PurineNucleosidaseActivity',s("Catalysis","of","the","reaction",":","a","N-D-ribosylpurine","+","H2O","=","a","purine","+","D-ribose","."),4157592). assertion_content_comment('tOboGo_PurineNucleosidaseReaction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228099). assertion_content_comment('tOboGo_PurineNucleosideBinding',s("Interacting","selectively","and","non-covalently","with","a","purine","nucleoside",",","a","compound","consisting","of","a","purine","base","linked","either","to","ribose","or","deoxyribose","."),4331284). assertion_content_comment('tOboGo_PurineNucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","purine","nucleoside",",","one","of","a","family","of","organic","molecules","consisting","of","a","purine","base","covalently","bonded","to","a","sugar","ribose","(","a","ribonucleoside",")","or","deoxyribose","(","a","deoxyribonucleoside",")"),4181305). assertion_content_comment('tOboGo_PurineNucleosideBisphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","purine","nucleoside","bisphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4266745). assertion_content_comment('tOboGo_PurineNucleosideBisphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","purine","nucleoside","bisphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4360953). assertion_content_comment('tOboGo_PurineNucleosideBisphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","purine","nucleoside","bisphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","deoxyribose","or","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4266742). assertion_content_comment('tOboGo_PurineNucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","nucleoside",",","one","of","a","family","of","organic","molecules","consisting","of","a","purine","base","covalently","bonded","to","a","sugar","ribose","(","a","ribonucleoside",")","or","deoxyribose","(","a","deoxyribonucleoside",")"),4227677). assertion_content_comment('tOboGo_PurineNucleosideDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","nucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4227125). assertion_content_comment('tOboGo_PurineNucleosideDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","nucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4258463). assertion_content_comment('tOboGo_PurineNucleosideDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","nucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4226983). assertion_content_comment('tOboGo_PurineNucleosideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","purine","nucleoside","is","synthesized","from","another","purine","nucleoside","."),4244617). assertion_content_comment('tOboGo_PurineNucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","one","of","a","family","of","organic","molecules","consisting","of","a","purine","base","covalently","bonded","to","a","sugar","ribose","(","a","ribonucleoside",")","or","deoxyribose","(","a","deoxyribonucleoside",")"),4045900). assertion_content_comment('tOboGo_PurineNucleosideMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","nucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4226904). assertion_content_comment('tOboGo_PurineNucleosideMonophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","nucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4226607). assertion_content_comment('tOboGo_PurineNucleosideMonophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","nucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4191823). assertion_content_comment('tOboGo_PurineNucleosideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","purine","nucleoside",",","a","purine","base","covalently","bonded","to","a","ribose","or","deoxyribose","sugar",",","from","one","side","of","a","membrane","to","the","other","."),4166890). assertion_content_comment('tOboGo_PurineNucleosideTransmembraneTransport',s("The","directed","movement","of","a","purine","nucleoside","across","a","membrane",".","A","purine","nucleoside","is","a","purine","base","covalently","bonded","to","a","ribose","or","deoxyribose","sugar",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4164456). assertion_content_comment('tOboGo_PurineNucleosideTransport',s("The","directed","movement","of","a","purine","nucleoside",",","a","purine","base","covalently","bonded","to","a","ribose","or","deoxyribose","sugar",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053850). assertion_content_comment('tOboGo_PurineNucleosideTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","nucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4227021). assertion_content_comment('tOboGo_PurineNucleosideTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","nucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4005232). assertion_content_comment('tOboGo_PurineNucleosideTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","nucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4005229). assertion_content_comment('tOboGo_PurineNucleotideBinding',s("Interacting","selectively","and","non-covalently","with","purine","nucleotides",",","any","compound","consisting","of","a","purine","nucleoside","esterified","with","(","ortho",")","phosphate","."),4218678). assertion_content_comment('tOboGo_PurineNucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","purine","nucleotide",",","a","compound","consisting","of","nucleoside","(","a","purine","base","linked","to","a","deoxyribose","or","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4027707). assertion_content_comment('tOboGo_PurineNucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","purine","nucleotide",",","a","compound","consisting","of","nucleoside","(","a","purine","base","linked","to","a","deoxyribose","or","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4005188). assertion_content_comment('tOboGo_PurineNucleotideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","purine","nucleotide","is","synthesized","from","another","purine","nucleotide","."),4294685). assertion_content_comment('tOboGo_PurineNucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","purine","nucleotide",",","a","compound","consisting","of","nucleoside","(","a","purine","base","linked","to","a","deoxyribose","or","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4005095). assertion_content_comment('tOboGo_PurineNucleotideSalvage',s("Any","process","which","produces","a","purine","nucleotide","from","derivatives","of","it",",","without","de","novo","synthesis","."),4288290). assertion_content_comment('tOboGo_PurineNucleotideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","purine","nucleotide",",","any","compound","consisting","of","a","purine","nucleoside","esterified","with","(","ortho",")","phosphate",",","from","one","side","of","a","membrane","to","the","other","."),4181584). assertion_content_comment('tOboGo_PurineNucleotideTransport',s("The","directed","movement","of","a","purine","nucleotide",",","any","compound","consisting","of","a","purine","nucleoside","esterified","with","(","ortho",")","phosphate",",","into",",","out","of","or","within","a","cell","."),4181613). assertion_content_comment('tOboGo_PurinePyrimidineNucleosideDiphosphateReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4227527). assertion_content_comment('tOboGo_PurinergicNucleotideReceptorActivity',s("Combining","with","a","purine","nucleotide","to","initiate","a","change","in","cell","activity","."),4300715). assertion_content_comment('tOboGo_PurinergicNucleotideReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","receptor","binding","to","an","extracellular","purine","nucleotide","to","initiate","a","change","in","cell","activity","."),4378260). assertion_content_comment('tOboGo_PurinergicReceptorActivity',s("Combining","with","a","purine","or","purine","derivative","(","purine","nucleoside","or","purine","nucleotide",")","to","initiate","a","change","in","cell","activity","."),4300711). assertion_content_comment('tOboGo_PurinergicReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","receptor","binding","to","an","extracellular","purine","or","purine","derivative","to","initiate","a","change","in","cell","activity","."),4108423). assertion_content_comment('tOboGo_PurineRibonucleosideBinding',s("Interacting","selectively","and","non-covalently","with","a","purine","ribonucleoside",",","a","compound","consisting","of","a","purine","base","linked","to","ribose","."),4331287). assertion_content_comment('tOboGo_PurineRibonucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","purine","ribonucleoside",",","a","nucleoside","in","which","purine","base","is","linked","to","a","ribose","(","beta-D-ribofuranose",")","molecule","."),4181328). assertion_content_comment('tOboGo_PurineRibonucleosideBisphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","purine","ribonucleoside","bisphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4266764). assertion_content_comment('tOboGo_PurineRibonucleosideBisphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","purine","ribonucleoside","bisphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4360992). assertion_content_comment('tOboGo_PurineRibonucleosideBisphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","purine","ribonucleoside","bisphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","one","phosphate","group","attached","to","each","of","two","different","hydroxyl","groups","on","the","sugar","."),4266761). assertion_content_comment('tOboGo_PurineRibonucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","purine","ribonucleoside",",","a","nucleoside","in","which","purine","base","is","linked","to","a","ribose","(","beta-D-ribofuranose",")","molecule","."),4227914). assertion_content_comment('tOboGo_PurineRibonucleosideDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","ribonucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4227882). assertion_content_comment('tOboGo_PurineRibonucleosideDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","ribonucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4258487). assertion_content_comment('tOboGo_PurineRibonucleosideDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","ribonucleoside","diphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4227422). assertion_content_comment('tOboGo_PurineRibonucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","ribonucleoside",",","a","nucleoside","in","which","purine","base","is","linked","to","a","ribose","(","beta-D-ribofuranose",")","molecule","."),4045905). assertion_content_comment('tOboGo_PurineRibonucleosideMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","ribonucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4226929). assertion_content_comment('tOboGo_PurineRibonucleosideMonophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","ribonucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4226628). assertion_content_comment('tOboGo_PurineRibonucleosideMonophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","ribonucleoside","monophosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4226625). assertion_content_comment('tOboGo_PurineRibonucleosideSalvage',s("Any","process","which","produces","a","purine","nucleoside","from","derivatives","of","it",",","without","de","novo","synthesis","."),4227485). assertion_content_comment('tOboGo_PurineRibonucleosideTriphosphateBinding',s("Interacting","selectively","and","non-covalently","with","a","purine","ribonucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4218714). assertion_content_comment('tOboGo_PurineRibonucleosideTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","purine","ribonucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4227166). assertion_content_comment('tOboGo_PurineRibonucleosideTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","ribonucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4005333). assertion_content_comment('tOboGo_PurineRibonucleosideTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","purine","ribonucleoside","triphosphate",",","a","compound","consisting","of","a","purine","base","linked","to","a","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4005330). assertion_content_comment('tOboGo_PurineRibonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","purine","ribonucleotide",",","any","compound","consisting","of","a","purine","ribonucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","ribose","moiety","."),4218702). assertion_content_comment('tOboGo_PurineRibonucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","purine","ribonucleotide",",","a","compound","consisting","of","ribonucleoside","(","a","purine","base","linked","to","a","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4226921). assertion_content_comment('tOboGo_PurineRibonucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","purine","ribonucleotide",",","a","compound","consisting","of","ribonucleoside","(","a","purine","base","linked","to","a","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4005286). assertion_content_comment('tOboGo_PurineRibonucleotideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","purine","ribonucleotide","is","synthesized","from","another","purine","ribonucleotide","."),4294687). assertion_content_comment('tOboGo_PurineRibonucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","purine","ribonucleotide",",","a","compound","consisting","of","ribonucleoside","(","a","purine","base","linked","to","a","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4005268). assertion_content_comment('tOboGo_PurineRibonucleotideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","purine","ribonucleotide",",","any","compound","consisting","of","a","purine","ribonucleoside","(","a","purine","organic","base","attached","to","a","ribose","sugar",")","esterified","with","(","ortho",")","phosphate",",","from","one","side","of","a","membrane","to","the","other","."),4216362). assertion_content_comment('tOboGo_PurineRibonucleotideTransport',s("The","directed","movement","of","a","purine","ribonucleotide",",","any","compound","consisting","of","a","purine","ribonucleoside","(","a","purine","organic","base","attached","to","a","ribose","sugar",")","esterified","with","(","ortho",")","phosphate",",","into",",","out","of","or","within","a","cell","."),4181615). assertion_content_comment('tOboGo_PuromycinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","puromycin",",","an","aminonucleoside","antibiotic","that","is","a","potent","inhibitor","of","translation",";","produced","by","the","bacterium","Streptomyces","alboniger","."),4325182). assertion_content_comment('tOboGo_PuromycinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","puromycin",",","3","'","-deoxy-N",",","N-dimethyl-3","'","-","(","O-methyl-L-tyrosinamido",")","adenosine",",","an","aminonucleoside","antibiotic","that","is","a","potent","inhibitor","of","translation",";","produced","by","the","bacterium","Streptomyces","alboniger","."),4325179). assertion_content_comment('tOboGo_PutamenDevelopment',s("The","progression","of","the","putamen","over","time","from","its","initial","formation","until","its","mature","state",".","The","putamen","is","the","lens-shaped","basal","ganglion","involved","with","control","of","voluntary","movement","in","the","brain","."),4049503). assertion_content_comment('tOboGo_PutrescineAcetylation',s("The","modification","of","putrescine","by","addition","of","acetyl","groups","."),4337023). assertion_content_comment('tOboGo_PutrescineBinding',s("Interacting","selectively","and","non-covalently","with","putrescine",",","1",",","4-diaminobutane",",","the","polyamine","formed","by","decarboxylation","of","ornithine","and","the","metabolic","precursor","of","spermidine","and","spermine","."),4233356). assertion_content_comment('tOboGo_PutrescineBiosyntheticProcessFromArginine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","putrescine",",","1",",","4-diaminobutane",",","from","other","compounds",",","including","arginine","."),4338354). assertion_content_comment('tOboGo_PutrescineBiosyntheticProcessFromArginineUsingAgmatinase',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","putrescine",",","1",",","4-diaminobutane",",","from","other","compounds",",","including","arginine",";","in","this","pathway",",","arginine","is","converted","to","agmatine",",","and","agmatine","is","converted","to","putrescine","in","a","single","enzymatic","step","."),4338360). assertion_content_comment('tOboGo_PutrescineBiosyntheticProcessFromOrnithine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","putrescine",",","1",",","4-diaminobutane","by","decarboxylation","of","ornithine","."),4338373). assertion_content_comment('tOboGo_PutrescineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","putrescine",",","1",",","4-diaminobutane",";","putrescine","can","be","synthesized","from","arginine","or","ornithine","and","is","the","metabolic","precursor","of","spermidine","and","spermine","."),4258854). assertion_content_comment('tOboGo_PutrescineCarbamoyltransferaseActivity',s("Catalysis","of","the","reaction",":","carbamoyl","phosphate","+","putrescine","=","N-carbamoylputrescine","+","H","(","+",")","+","phosphate","."),4263464). assertion_content_comment('tOboGo_PutrescineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","putrescine",",","1",",","4-diaminobutane",";","putrescine","is","the","metabolic","precursor","of","spermidine","and","spermine","."),4258840). assertion_content_comment('tOboGo_PutrescineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","putrescine",",","1",",","4-diaminobutane",";","putrescine","can","be","formed","by","decarboxylation","of","ornithine","and","is","the","metabolic","precursor","of","spermidine","and","spermine","."),4258817). assertion_content_comment('tOboGo_Putrescine_OrnithineAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","putrescine","(","out",")","+","ornithine","(","in",")","=","putrescine","(","in",")","+","ornithine","(","out",")"),4292246). assertion_content_comment('tOboGo_PutrescineOxidaseActivity',s("Catalysis","of","the","reaction",":","putrescine","+","O2","+","H2O","=","4-aminobutanal","+","NH3","+","H2O2","."),4263478). assertion_content_comment('tOboGo_PutrescineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","putrescine","from","one","side","of","the","membrane","to","the","other",".","Putrescine","is","1",",","4-diaminobutane",",","the","polyamine","formed","by","decarboxylation","of","ornithine","and","the","metabolic","precursor","of","spermidine","and","spermine","."),4292244). assertion_content_comment('tOboGo_PutrescineTransport',s("The","directed","movement","of","putrescine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Putrescine","is","1",",","4-diaminobutane",",","the","polyamine","formed","by","decarboxylation","of","ornithine","and","the","metabolic","precursor","of","spermidine","and","spermine","."),4293898). assertion_content_comment('tOboGo_PyochelinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","siderochrome","pyochelin","(","2-","(","2-o-hydroxyphenyl-2-thiazolin-4-yl",")","-3-methylthiazolidine-4-carboxylic","acid",")"),4315353). assertion_content_comment('tOboGo_PyochelinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","siderochrome","pyochelin","(","2-","(","2-o-hydroxyphenyl-2-thiazolin-4-yl",")","-3-methylthiazolidine-4-carboxylic","acid",")"),4315385). assertion_content_comment('tOboGo_PyochelinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","siderochrome","pyochelin","(","2-","(","2-o-hydroxyphenyl-2-thiazolin-4-yl",")","-3-methylthiazolidine-4-carboxylic","acid",")"),4315350). assertion_content_comment('tOboGo_PyoverdineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","siderochrome","pyoverdine","."),4373812). assertion_content_comment('tOboGo_PyoverdineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","siderochrome","pyoverdine","."),4374173). assertion_content_comment('tOboGo_PyoverdineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","siderochrome","pyoverdine","."),4373808). assertion_content_comment('tOboGo_PyramidalNeuronDevelopment',s("The","progression","of","a","pyramidal","neuron","from","its","initial","formation","to","its","mature","state","."),4050747). assertion_content_comment('tOboGo_PyramidalNeuronDifferentiation',s("The","process","in","which","a","neuroblast","or","one","of","its","progeny","commits","to","a","pyramidal","neuron","fate",",","migrates","from","the","ventricular","zone","to","the","appropriate","layer","in","the","cortex","and","develops","into","a","mature","neuron","."),4050663). assertion_content_comment('tOboGo_PyramidalNeuronMigration',s("The","migration","of","pyramidal","a","neuron","precursor","from","the","ventricular","zone","to","the","correct","layer","of","the","cerebral","cortex","."),4050993). assertion_content_comment('tOboGo_PyramidDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","kidney","pyramids","over","time",",","from","its","formation","to","the","mature","structure",".","Kidney","pyramids","are","the","conical","masses","that","constitute","the","renal","medulla","in","a","multi-lobed","mammalian","kidney",";","they","contain","the","loops","of","Henle","and","the","medullary","collecting","ducts","."),4123709). assertion_content_comment('tOboGo_PyranoseDehydrogenaseAcceptorActivity',s("Catalysis","of","the","reactions",":","pyranose","+","acceptor","=","2-dehydropyranose","(","or","3-dehydropyranose","or","2",",","3-didehydropyranose",")","+","reduced","acceptor",",","and","a","pyranoside","+","acceptor","=","a","3-dehydropyranoside","(","or","3",",","4-didehydropyranoside",")","+","reduced","acceptor","."),4341915). assertion_content_comment('tOboGo_PyranoseOxidaseActivity',s("Catalysis","of","the","reaction",":","D-glucose","+","O","(","2",")","=","2-dehydro-D-glucose","+","H","(","2",")","O","(","2",")"),4263513). assertion_content_comment('tOboGo_PyrazolylalanineSynthaseActivity',s("Catalysis","of","the","reaction",":","L-serine","+","pyrazole","=","3-","(","pyrazol-1-yl",")","-L-alanine","+","H","(","2",")","O","."),4263501). assertion_content_comment('tOboGo_PyreneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","pyrene","+","2","H","+","+","2","e-","+","O2","=","cis-4",",","5-dihydroxy-4",",","5-dihydropyrene","."),4350340). assertion_content_comment('tOboGo_PyrethroidResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4246015). assertion_content_comment('tOboGo_PyrethroidSusceptibilityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4304425). assertion_content_comment('tOboGo_PyridineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyridine",",","a","nitrogenous","base","(","C5H5N",")","obtained","from","the","distillation","of","bone","oil","or","coal","tar",",","and","by","the","decomposition","of","certain","alkaloids",",","as","a","colorless","liquid","with","a","peculiar","pungent","odor","."),4354143). assertion_content_comment('tOboGo_PyridineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyridine",",","a","nitrogenous","base","(","C5H5N",")","obtained","from","the","distillation","of","bone","oil","or","coal","tar",",","and","by","the","decomposition","of","certain","alkaloids",",","as","a","colorless","liquid","with","a","peculiar","pungent","odor","."),4354159). assertion_content_comment('tOboGo_PyridineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyridine",",","a","nitrogenous","base","(","C5H5N",")","obtained","from","the","distillation","of","bone","oil","or","coal","tar",",","and","by","the","decomposition","of","certain","alkaloids",",","as","a","colorless","liquid","with","a","peculiar","pungent","odor","."),4242633). assertion_content_comment('tOboGo_PyridineNucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","pyridine","nucleoside",",","one","of","a","family","of","organic","molecules","consisting","of","a","pyridine","base","covalently","bonded","to","a","sugar",",","usually","ribose","."),4171765). assertion_content_comment('tOboGo_PyridineNucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","pyridine","nucleoside",",","a","nucleoside","in","which","a","pyridine","base","covalently","bonded","to","a","sugar",",","usually","ribose","."),4176921). assertion_content_comment('tOboGo_PyridineNucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","pyridine","nucleoside",",","a","nucleoside","in","which","a","pyridine","base","covalently","bonded","to","a","sugar",",","usually","ribose","."),4171761). assertion_content_comment('tOboGo_PyridineNucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pyridine","nucleotide",",","a","nucleotide","characterized","by","a","pyridine","derivative","as","a","nitrogen","base","."),4229201). assertion_content_comment('tOboGo_PyridineNucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","pyridine","nucleotide",",","a","nucleotide","characterized","by","a","pyridine","derivative","as","a","nitrogen","base","."),4229146). assertion_content_comment('tOboGo_PyridineNucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","pyridine","nucleotide",",","a","nucleotide","characterized","by","a","pyridine","derivative","as","a","nitrogen","base","."),4021157). assertion_content_comment('tOboGo_PyridineNucleotideSalvage',s("Any","process","that","generates","a","pyridine","nucleotide",",","a","nucleotide","characterized","by","a","pyridine","derivative","as","a","nitrogen","base",",","from","derivatives","of","them","without","de","novo","synthesis","."),4239501). assertion_content_comment('tOboGo_PyridoxalBinding',s("Interacting","selectively","and","non-covalently","with","pyridoxal",",","3-hydroxy-5-","(","hydroxymethyl",")","-2-methylpyridine-4-carbaldehyde",",","a","form","of","vitamin","B6","."),4174259). assertion_content_comment('tOboGo_PyridoxalBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","3-hydroxy-5-","(","hydroxymethyl",")","-2-methyl-4-pyridinecarboxaldehyde",",","one","of","the","vitamin","B6","compounds","."),4314804). assertion_content_comment('tOboGo_PyridoxalKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","pyridoxal","=","ADP","+","pyridoxal","5","'","-phosphate","."),4254253). assertion_content_comment('tOboGo_PyridoxalMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","3-hydroxy-5-","(","hydroxymethyl",")","-2-methyl-4-pyridinecarboxaldehyde",",","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4314800). assertion_content_comment('tOboGo_PyridoxalOxidaseActivity',s("Catalysis","of","the","reaction",":","pyridoxal","+","H2O","+","O2","=","4-pyridoxate","+","hydrogen","peroxide","."),4200744). assertion_content_comment('tOboGo_PyridoxalPhosphataseActivity',s("Catalysis","of","the","reaction",":","pyridoxal","5","'","-phosphate","+","H2O","=","pyridoxal","+","phosphate","."),4343454). assertion_content_comment('tOboGo_PyridoxalPhosphateBinding',s("Interacting","selectively","and","non-covalently","with","pyridoxal","5","'","phosphate",",","3-hydroxy-5-","(","hydroxymethyl",")","-2-methyl4-pyridine","carboxaldehyde","5","'","phosphate",",","the","biologically","active","form","of","vitamin","B6","."),4311200). assertion_content_comment('tOboGo_PyridoxalPhosphateBiosyntheticProcessFromPyridoxamine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyridoxal","phosphate",",","the","active","form","of","vitamin","B6",",","from","pyridoxamine","."),4334068). assertion_content_comment('tOboGo_PyridoxalPhosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyridoxal","phosphate",",","pyridoxal","phosphorylated","at","the","hydroxymethyl","group","of","C-5",",","the","active","form","of","vitamin","B6","."),4258769). assertion_content_comment('tOboGo_PyridoxalPhosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyridoxal","phosphate",",","pyridoxal","phosphorylated","at","the","hydroxymethyl","group","of","C-5",",","the","active","form","of","vitamin","B6","."),4333665). assertion_content_comment('tOboGo_PyridoxalPhosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyridoxal","phosphate",",","pyridoxal","phosphorylated","at","the","hydroxymethyl","group","of","C-5",",","the","active","form","of","vitamin","B6","."),4258764). assertion_content_comment('tOboGo_PyridoxalPhosphateTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","pyridoxal","phosphate","into",",","out","of","or","within","a","cell",",","or","between","cells",";","pyridoxal","phosphate","is","pyridoxal","phosphorylated","at","the","hydroxymethyl","group","of","C-5",",","and","is","the","active","form","of","vitamin","B6","."),4320421). assertion_content_comment('tOboGo_PyridoxalPhosphateTransport',s("The","directed","movement","of","pyridoxal","phosphate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",";","pyridoxal","phosphate","is","pyridoxal","phosphorylated","at","the","hydroxymethyl","group","of","C-5",",","and","is","the","active","form","of","vitamin","B6","."),4320362). assertion_content_comment('tOboGo_PyridoxalTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","pyridoxal","across","a","membrane","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Pyridoxal",",","3-hydroxy-5-","(","hydroxymethyl",")","-2-methyl-4-pyridinecarboxaldehyde",",","is","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4320381). assertion_content_comment('tOboGo_PyridoxalTransport',s("The","directed","movement","of","pyridoxal","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Pyridoxal",",","3-hydroxy-5-","(","hydroxymethyl",")","-2-methyl-4-pyridinecarboxaldehyde",",","is","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4320353). assertion_content_comment('tOboGo_PyridoxamineBinding',s("Interacting","selectively","and","non-covalently","with","pyridoxamine",",","4-","(","aminomethyl",")","-5-","(","hydroxymethyl",")","-2-methylpyridin-3-ol",",","a","form","of","vitamin","B6","."),4174268). assertion_content_comment('tOboGo_PyridoxamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","4-","(","aminomethyl",")","-5-","(","hydroxymethyl",")","-2-methylpyridin-3-ol",",","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4314842). assertion_content_comment('tOboGo_PyridoxamineTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","pyridoxamine","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Pyridoxamine",",","4-","(","aminomethyl",")","-5-","(","hydroxymethyl",")","-2-methylpyridin-3-ol",",","is","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4320431). assertion_content_comment('tOboGo_PyridoxamineTransport',s("The","directed","movement","of","pyridoxamine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Pyridoxamine",",","4-","(","aminomethyl",")","-5-","(","hydroxymethyl",")","-2-methylpyridin-3-ol",",","is","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4320391). assertion_content_comment('tOboGo_PyridoxineBinding',s("Interacting","selectively","and","non-covalently","with","pyridoxine",",","4",",","5-bis","(","hydroxymethyl",")","-2-methylpyridin-3-ol",",","a","form","of","vitamin","B6","."),4174277). assertion_content_comment('tOboGo_PyridoxineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyridoxine",",","2-methyl-3-hydroxy-4",",","5-bis","(","hydroxymethyl",")","pyridine",",","one","of","the","vitamin","B6","compounds","."),4253043). assertion_content_comment('tOboGo_PyridoxineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyridoxine",",","2-methyl-3-hydroxy-4",",","5-bis","(","hydroxymethyl",")","pyridine",",","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4253016). assertion_content_comment('tOboGo_PyridoxineTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","pyridoxine","across","a","membrane","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Pyridoxine",",","2-methyl-3-hydroxy-4",",","5-bis","(","hydroxymethyl",")","pyridine",",","is","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4320410). assertion_content_comment('tOboGo_PyridoxineTransport',s("The","directed","movement","of","pyridoxine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Pyridoxine",",","2-methyl-3-hydroxy-4",",","5-bis","(","hydroxymethyl",")","pyridine",",","is","one","of","the","vitamin","B6","compounds",".","Pyridoxal",",","pyridoxamine","and","pyridoxine","are","collectively","known","as","vitamin","B6",",","and","are","efficiently","converted","to","the","biologically","active","form","of","vitamin","B6",",","pyridoxal","phosphate","."),4320400). assertion_content_comment('tOboGo_PyrimidineBaseBinding',s("Interacting","selectively","and","non-covalently","with","a","pyrimidine","base",",","an","organic","nitrogenous","base","with","a","pyrimidine","skeleton","."),4373658). assertion_content_comment('tOboGo_PyrimidineBaseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","bases",",","1",",","3-diazine",",","organic","nitrogenous","bases","."),4226723). assertion_content_comment('tOboGo_PyrimidineBaseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","bases",",","1",",","3-diazine",",","organic","nitrogenous","bases","."),4226315). assertion_content_comment('tOboGo_PyrimidineBaseFermentation',s("The","anaerobic","conversion","of","pyrimidine","bases",",","yielding","energy","in","the","form","of","ATP","."),4325002). assertion_content_comment('tOboGo_PyrimidineBaseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","bases",",","1",",","3-diazine",",","organic","nitrogenous","bases","."),4010799). assertion_content_comment('tOboGo_PyrimidineBaseSalvage',s("Any","process","that","generates","pyrimidine","bases",",","1",",","3-diazine","organic","nitrogenous","bases",",","from","derivatives","of","them","without","de","novo","synthesis","."),4226168). assertion_content_comment('tOboGo_PyrimidineBaseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","pyrimidine","bases",",","one","of","the","two","classes","of","nitrogen-containing","ring","compounds","found","in","DNA","and","RNA",",","from","one","side","of","a","membrane","to","the","other","."),4216486). assertion_content_comment('tOboGo_PyrimidineBaseTransport',s("The","directed","movement","of","pyrimidine","bases",",","one","of","the","two","classes","of","nitrogen-containing","ring","compounds","found","in","DNA","and","RNA",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083311). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideBinding',s("Interacting","selectively","and","non-covalently","with","a","pyrimidine","deoxyribonucleoside",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","deoxyribose","."),4331350). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","one","of","a","family","of","organic","molecules","consisting","of","a","pyrimidine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4226012). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","one","of","a","family","of","organic","molecules","consisting","of","a","pyrimidine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4226436). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","deoxyribonucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223053). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","deoxynucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223280). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","deoxynucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223049). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","pyrimidine","deoxyribonucleoside","is","synthesized","from","another","deoxyribopyrimidine","nucleoside","."),4244606). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","one","of","a","family","of","organic","molecules","consisting","of","a","pyrimidine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4226008). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","deoxynucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4225599). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideMonophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","deoxynucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4223388). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideMonophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","deoxynucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4223384). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideSalvage',s("Any","process","that","generates","a","pyrimidine","deoxyribonucleoside","from","derivatives","of","it",",","without","de","novo","synthesis","."),4226018). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222915). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4223631). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleosideTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222880). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","pyrimidine","deoxyribonucleotide",",","any","compound","consisting","of","a","pyrimidine","deoxyribonucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","deoxyribose","moiety","."),4331889). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pyrimidine","deoxyribonucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222909). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","pyrimidine","deoxyribonucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4223275). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleotideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","pyrimidine","deoxyribonucleotide","is","synthesized","from","another","pyrimidine","deoxyribonucleotide","."),4294643). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","pyrimidine","deoxynucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222877). assertion_content_comment('tOboGo_PyrimidineDeoxyribonucleotideSalvage',s("The","pathway","by","which","pyrimidine","bases","or","pyrimidine","deoxyribonucleotides","from","pyrimidine","nucleotide","breakdown","are","converted","back","to","pyrimidine","deoxyribonucleotides",".","The","salvage","pathway","is","important","where","there","is","no","de","novo","pyrimidine","deoxyribonucleotide","biosynthesis","."),4225849). assertion_content_comment('tOboGo_PyrimidineDimerRepair',s("The","repair","of","UV-induced","T-T",",","C-T","and","C-C","dimers","."),4223801). assertion_content_comment('tOboGo_PyrimidineMetabolicProcess',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4226868). assertion_content_comment('tOboGo_PyrimidineNucleosideBinding',s("Interacting","selectively","and","non-covalently","with","a","pyrimidine","nucleoside",",","a","compound","consisting","of","a","pyrimidine","base","linked","either","to","ribose","or","deoxyribose","."),4331254). assertion_content_comment('tOboGo_PyrimidineNucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","one","of","a","family","of","organic","molecules","consisting","of","a","pyrimidine","base","covalently","bonded","to","a","sugar","ribose","(","a","ribonucleoside",")","or","deoxyribose","(","a","deoxyribonucleoside",")"),4225955). assertion_content_comment('tOboGo_PyrimidineNucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","one","of","a","family","of","organic","molecules","consisting","of","a","pyrimidine","base","covalently","bonded","to","a","sugar","ribose","(","a","ribonucleoside",")","or","deoxyribose","(","a","deoxyribonucleoside",")"),4226431). assertion_content_comment('tOboGo_PyrimidineNucleosideDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","nucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223003). assertion_content_comment('tOboGo_PyrimidineNucleosideDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","nucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223132). assertion_content_comment('tOboGo_PyrimidineNucleosideDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","nucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223000). assertion_content_comment('tOboGo_PyrimidineNucleosideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","pyrimidine","nucleoside","is","synthesized","from","another","pyrimidine","nucleoside","."),4244603). assertion_content_comment('tOboGo_PyrimidineNucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","pyrimidine","nucleoside",",","one","of","a","family","of","organic","molecules","consisting","of","a","pyrimidine","base","covalently","bonded","to","ribose","(","a","ribonucleoside",")","or","deoxyribose","(","a","deoxyribonucleoside",")"),4181374). assertion_content_comment('tOboGo_PyrimidineNucleosideMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","nucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4225574). assertion_content_comment('tOboGo_PyrimidineNucleosideMonophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","nucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4223340). assertion_content_comment('tOboGo_PyrimidineNucleosideMonophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","nucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4223337). assertion_content_comment('tOboGo_PyrimidineNucleosideSalvage',s("Any","process","that","generates","a","pyrimidine","nucleoside",",","one","of","a","family","of","organic","molecules","consisting","of","a","pyrimidine","base","covalently","bonded","to","a","sugar","ribose",",","from","derivatives","of","it",",","without","de","novo","synthesis","."),4225961). assertion_content_comment('tOboGo_PyrimidineNucleosideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","pyrimidine","nucleoside",",","a","pyrimidine","base","covalently","bonded","to","a","ribose","or","deoxyribose","sugar","from","one","side","of","a","membrane","to","the","other","."),4295622). assertion_content_comment('tOboGo_PyrimidineNucleosideTransport',s("The","directed","movement","of","a","pyrimidine","nucleoside",",","a","pyrimidine","base","covalently","bonded","to","a","ribose","or","deoxyribose","sugar",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053818). assertion_content_comment('tOboGo_PyrimidineNucleosideTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","nucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222665). assertion_content_comment('tOboGo_PyrimidineNucleosideTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","nucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4223608). assertion_content_comment('tOboGo_PyrimidineNucleosideTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","nucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","or","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222662). assertion_content_comment('tOboGo_PyrimidineNucleotideBinding',s("Interacting","selectively","and","non-covalently","with","pyrimidine","nucleotide",",","any","compound","consisting","of","a","pyrimidine","nucleoside","esterified","with","(","ortho",")","phosphate","."),4237081). assertion_content_comment('tOboGo_PyrimidineNucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pyrimidine","nucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","deoxyribose","or","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222630). assertion_content_comment('tOboGo_PyrimidineNucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","pyrimidine","nucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","deoxyribose","or","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4223111). assertion_content_comment('tOboGo_PyrimidineNucleotideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","pyrimidine","nucleotide","is","synthesized","from","another","pyrimidine","nucleotide","."),4294641). assertion_content_comment('tOboGo_PyrimidineNucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","pyrimidine","nucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","deoxyribose","or","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222623). assertion_content_comment('tOboGo_PyrimidineNucleotideSalvage',s("Any","process","which","produces","a","pyrimidine","nucleotide","from","derivatives","of","it",",","without","de","novo","synthesis","."),4225847). assertion_content_comment('tOboGo_PyrimidineNucleotideSugarTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","pyrimidine","nucleotide-sugar","from","one","side","of","the","membrane","to","the","other",".","Pyrimidine","nucleotide-sugars","are","pyrimidine","nucleotides","in","glycosidic","linkage","with","a","monosaccharide","or","monosaccharide","derivative","."),4219435). assertion_content_comment('tOboGo_PyrimidineNucleotideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","pyrimidine","nucleotide",",","any","compound","consisting","of","a","pyrimidine","nucleoside","esterified","with","(","ortho",")","phosphate",",","from","one","side","of","a","membrane","to","the","other","."),4295593). assertion_content_comment('tOboGo_PyrimidineNucleotideTransport',s("The","directed","movement","of","a","pyrimidine","nucleotide",",","any","compound","consisting","of","a","pyrimidine","nucleoside","esterified","with","(","ortho",")","phosphate",",","into",",","out","of","or","within","a","cell","."),4228765). assertion_content_comment('tOboGo_PyrimidineRibonucleosideBinding',s("Interacting","selectively","and","non-covalently","with","a","pyrimidine","ribonucleoside",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","ribose","."),4331267). assertion_content_comment('tOboGo_PyrimidineRibonucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","ribonucleoside",",","a","nucleoside","in","which","a","pyrimidine","base","is","linked","to","a","ribose","(","beta-D-ribofuranose",")","molecule","."),4226088). assertion_content_comment('tOboGo_PyrimidineRibonucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","ribonucleoside",",","a","nucleoside","in","which","a","pyrimidine","base","is","linked","to","a","ribose","(","beta-D-ribofuranose",")","molecule","."),4226479). assertion_content_comment('tOboGo_PyrimidineRibonucleosideDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","ribonucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4225784). assertion_content_comment('tOboGo_PyrimidineRibonucleosideDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","ribonucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223195). assertion_content_comment('tOboGo_PyrimidineRibonucleosideDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","ribonucleoside","diphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223176). assertion_content_comment('tOboGo_PyrimidineRibonucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","ribonucleoside",",","a","nucleoside","in","which","pyrimidine","base","is","linked","to","a","ribose","(","beta-D-ribofuranose",")","molecule","."),4181380). assertion_content_comment('tOboGo_PyrimidineRibonucleosideMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","ribonucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4225658). assertion_content_comment('tOboGo_PyrimidineRibonucleosideMonophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","ribonucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4223503). assertion_content_comment('tOboGo_PyrimidineRibonucleosideMonophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","ribonucleoside","monophosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","phosphate","on","the","sugar","."),4223499). assertion_content_comment('tOboGo_PyrimidineRibonucleosideTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","ribonucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222746). assertion_content_comment('tOboGo_PyrimidineRibonucleosideTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyrimidine","ribonucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4223661). assertion_content_comment('tOboGo_PyrimidineRibonucleosideTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrimidine","ribonucleoside","triphosphate",",","a","compound","consisting","of","a","pyrimidine","base","linked","to","a","ribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222726). assertion_content_comment('tOboGo_PyrimidineRibonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","pyrimidine","ribonucleotide",",","any","compound","consisting","of","a","pyrimidine","ribonucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","ribose","moiety","."),4331878). assertion_content_comment('tOboGo_PyrimidineRibonucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pyrimidine","ribonucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222740). assertion_content_comment('tOboGo_PyrimidineRibonucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","pyrimidine","ribonucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4223190). assertion_content_comment('tOboGo_PyrimidineRibonucleotideInterconversion',s("The","chemical","reactions","and","pathways","by","which","a","pyrimidine","ribonucleotide","is","synthesized","from","another","pyrimidine","ribonucleotide","."),4294665). assertion_content_comment('tOboGo_PyrimidineRibonucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","pyrimidine","ribonucleotide",",","a","compound","consisting","of","nucleoside","(","a","pyrimidine","base","linked","to","a","ribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222723). assertion_content_comment('tOboGo_PyrimidineRibonucleotideSalvage',s("The","pathway","by","which","pyrimidine","bases","or","pyrimidine","ribonucleosides","from","pyrimidine","nucleotide","breakdown","are","converted","back","to","pyrimidine","ribonucleotides",".","The","salvage","pathway","is","important","where","there","is","no","de","novo","pyrimidine","nucleotide","biosynthesis","."),4225903). assertion_content_comment('tOboGo_PyrimidodiazepineSynthaseActivity',s("Catalysis","of","the","reaction",":","a","pyrimidodiazepine","+","oxidized","glutathione","=","6-pyruvoyltetrahydropterin","+","2","glutathione","."),4200832). assertion_content_comment('tOboGo_PyrinDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","Pyrin","(","PAAD/DAPIN",")","domain",",","a","protein-protein","interaction","domain","that","has","the","same","fold","as","the","Death","domain","."),4330839). assertion_content_comment('tOboGo_PyrithiamineDeaminaseActivity',s("Catalysis","of","the","reaction",":","1-","(","4-amino-2-methylpyrimid-5-ylmethyl",")","-3-","(","beta-hydroxyethyl",")","-2-methylpyridinium","bromide","+","H2O","=","1-","(","4-hydroxy-2-methylpyrimid-5-ylmethyl",")","-3-","(","beta-hydroxyethyl",")","-2-methylpyridinium","bromide","+","NH3","."),4263579). assertion_content_comment('tOboGo_PyrogallolHydroxytransferaseActivity',s("Catalysis","of","the","reaction",":","1",",","2",",","3",",","5-tetrahydroxybenzene","+","1",",","2",",","3-trihydroxybenzene","=","1",",","3",",","5-trihydroxybenzene","+","1",",","2",",","3",",","5-tetrahydroxybenzene","."),4275322). assertion_content_comment('tOboGo_PyrophosphataseActivity',s("Catalysis","of","the","hydrolysis","of","a","pyrophosphate","bond","between","two","phosphate","groups",",","leaving","one","phosphate","on","each","of","the","two","fragments","."),4159551). assertion_content_comment('tOboGo_Pyroptosis',s("A","type","of","programmed","cell","death","that","results","from","the","apical","activation","of","caspase-1","."),4174322). assertion_content_comment('tOboGo_PyrroloquinolineQuinoneBinding',s("Interacting","selectively","and","non-covalently","with","pyrroloquinoline","quinone",",","PQQ",",","the","coenzyme","or","the","prosthetic","group","of","certain","alcohol","dehydrogenases","and","glucose","dehydrogenases","."),4178029). assertion_content_comment('tOboGo_PyrroloquinolineQuinoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","cofactor","pyrroloquinoline","quinone","(","PQQ",")",";","it","is","synthesized","from","a","small","peptide","containing","tyrosine","and","glutamic","acid",";","these","amino","acids","in","the","peptide","are","multiply","cross-linked","and","the","rest","of","the","peptide","is","removed","."),4285690). assertion_content_comment('tOboGo_PyrrolysineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrrolysine",",","N6-","{","[","(","2R",",","3R",")","-3-methyl-3",",","4-dihydro-2H-pyrrol-2-yl","]","carbonyl","}","-L-lysine","."),4172182). assertion_content_comment('tOboGo_PyrrolysineIncorporation',s("The","incorporation","of","pyrrolysine",",","also","known","as","lysine","methylamine","methyltransferase","cofactor","adduct",",","into","a","peptide",";","uses","a","special","tRNA","that","recognizes","the","UAG","codon","as","a","modified","lysine",",","rather","than","as","a","termination","codon",".","Pyrrolysine","may","be","synthesized","as","a","free","amino","acid","or","synthesized","from","a","lysine","charged","tRNA","before","its","incorporation",";","it","is","not","a","posttranslational","modification","of","peptidyl-lysine",";","this","modification","is","found","in","several","Methanosarcina","methylamine","methyltransferases","."),4308132). assertion_content_comment('tOboGo_PyrrolysineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyrrolysine",",","N6-","{","[","(","2R",",","3R",")","-3-methyl-3",",","4-dihydro-2H-pyrrol-2-yl","]","carbonyl","}","-L-lysine","."),4172178). assertion_content_comment('tOboGo_PyruvateBiosyntheticProcessFromAcetate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyruvate","from","other","compounds",",","including","acetate","."),4244654). assertion_content_comment('tOboGo_PyruvateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyruvate",",","2-oxopropanoate","."),4244648). assertion_content_comment('tOboGo_PyruvateCarboxylaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","bicarbonate","+","pyruvate","=","ADP","+","2","H","(","+",")","+","oxaloacetate","+","phosphate","."),4200795). assertion_content_comment('tOboGo_PyruvateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","pyruvate",",","2-oxopropanoate","."),4315399). assertion_content_comment('tOboGo_PyruvateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","a","2-oxo","acid","=","an","aldehyde","+","CO2","."),4201128). assertion_content_comment('tOboGo_PyruvateDehydrogenaseActivity',s("Catalysis","of","the","oxidative","decarboxylation","of","pyruvate","."),4201107). assertion_content_comment('tOboGo_PyruvateDehydrogenaseComplex',s("Complex","that","carries","out","the","oxidative","decarboxylation","of","pyruvate","to","form","acetyl-CoA",";","comprises","subunits","possessing","three","catalytic","activities",":","pyruvate","dehydrogenase","(","E1",")",",","dihydrolipoamide","S-acetyltransferase","(","E2",")",",","and","dihydrolipoamide","dehydrogenase","(","E3",")"),4009188). assertion_content_comment('tOboGo_PyruvateDehydrogenaseCytochromeActivity',s("Catalysis","of","the","reaction",":","pyruvate","+","ferricytochrome","b1","+","H2O","=","CO2","+","acetate","+","ferrocytochrome","b1","."),4248101). assertion_content_comment('tOboGo_PyruvateDehydrogenaseLipoamidePhosphataseActivity',s("Catalysis","of","the","reaction",":","[","pyruvate","dehydrogenase","(","lipoamide",")","]","phosphate","+","H2O","=","[","pyruvate","dehydrogenase","(","lipoamide",")","]","+","phosphate","."),4201238). assertion_content_comment('tOboGo_PyruvateDehydrogenaseLipoamidePhosphataseComplex',s("A","complex","of","a","regulatory","and","catalytic","subunit","that","catalyzes","the","dephosphorylation","and","concomitant","reactivation","of","the","alpha","subunit","of","the","E1","component","of","the","pyruvate","dehydrogenase","complex","."),4042190). assertion_content_comment('tOboGo_PyruvateDehydrogenaseLipoamidePhosphataseRegulatorActivity',s("Modification","of","the","activity","of","the","enzyme","[","pyruvate","dehydrogenase","(","lipoamide",")","]","phosphatase","."),4232848). assertion_content_comment('tOboGo_PyruvateDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","pyruvate","+","CoA","+","NAD","+","=","acetyl-CoA","+","CO2","+","NADH","."),4353947). assertion_content_comment('tOboGo_PyruvateDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","CoA","+","NADP","(","+",")","+","pyruvate","=","acetyl-CoA","+","CO","(","2",")","+","NADPH","."),4263633). assertion_content_comment('tOboGo_PyruvateFamilyAminoAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","amino","acid","that","requires","pyruvate","for","its","synthesis",",","e.g",".","alanine","."),4231718). assertion_content_comment('tOboGo_PyruvateFamilyAminoAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","amino","acid","that","requires","pyruvate","for","its","synthesis",",","e.g",".","alanine","."),4231690). assertion_content_comment('tOboGo_PyruvateFamilyAminoAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","amino","acid","that","requires","pyruvate","for","its","synthesis",",","e.g",".","alanine","."),4222271). assertion_content_comment('tOboGo_PyruvateFermentationToPropionate',s("The","anaerobic","conversion","of","pyruvate","to","propionate",",","yielding","energy","in","the","form","of","ATP",";","an","alternative","to","the","acrylate","pathway","to","produce","propionate","."),4244390). assertion_content_comment('tOboGo_PyruvateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","pyruvate","=","ADP","+","phosphoenolpyruvate","."),4201202). assertion_content_comment('tOboGo_PyruvateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","pyruvate",",","2-oxopropanoate","."),4030133). assertion_content_comment('tOboGo_PyruvateOxidaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","O","(","2",")","+","phosphate","+","pyruvate","=","acetyl","phosphate","+","CO","(","2",")","+","H","(","2",")","O","(","2",")"),4365940). assertion_content_comment('tOboGo_PyruvateOxidation',s("The","chemical","reactions","and","pathways","resulting","in","the","conversion","of","pyruvate","to","acetylphosphate","."),4258829). assertion_content_comment('tOboGo_PyruvatePhosphateDikinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","phosphate","+","pyruvate","=","AMP","+","diphosphate","+","2","H","(","+",")","+","phosphoenolpyruvate","."),4263612). assertion_content_comment('tOboGo_PyruvateSecondaryActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","pyruvate","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4219274). assertion_content_comment('tOboGo_PyruvateSynthaseActivity',s("Catalysis","of","the","reaction",":","pyruvate","+","CoA","+","2","oxidized","ferredoxin","=","acetyl-CoA","+","CO2","+","2","reduced","ferredoxin","+","2","H","+"),4237724). assertion_content_comment('tOboGo_PyruvateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","pyruvate",",","2-oxopropanoate",",","from","one","side","of","the","membrane","to","the","other","."),4219271). assertion_content_comment('tOboGo_PyruvateTransport',s("The","directed","movement","of","pyruvate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4228597). assertion_content_comment('tOboGo_PyruvateWaterDikinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","H","(","2",")","O","+","pyruvate","=","AMP","+","3","H","(","+",")","+","phosphate","+","phosphoenolpyruvate","."),4248040). assertion_content_comment('tOboGo_PyruvyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","pyruvyl","(","oxopropanoyl",")","group","from","one","compound","to","another","."),4362240). assertion_content_comment('tOboGo_QuaternaryAmmoniumGroupBinding',s("Interacting","selectively","and","non-covalently","with","a","quaternary","ammonium","group",",","including","glycine","betaine",",","choline",",","carnitine","and","proline",".","A","quaternary","ammonium","group","is","any","compound","that","can","be","regarded","as","derived","from","ammonium","hydroxide","or","an","ammonium","salt","by","replacement","of","all","four","hydrogen","atoms","of","the","NH4","+","ion","by","organic","groups","."),4273043). assertion_content_comment('tOboGo_QuaternaryAmmoniumGroup_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","quaternary","ammonium","group","(","out",")","+","H","+","(","out",")","=","quaternary","ammonium","group","(","in",")","+","H","+","(","in",")"),4290155). assertion_content_comment('tOboGo_QuaternaryAmmoniumGroupTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","quaternary","ammonium","groups","from","one","side","of","a","membrane","to","the","other",".","Quaternary","ammonium","groups","are","any","compound","that","can","be","regarded","as","derived","from","ammonium","hydroxide","or","an","ammonium","salt","by","replacement","of","all","four","hydrogen","atoms","of","the","NH4","+","ion","by","organic","groups","."),4290151). assertion_content_comment('tOboGo_QuaternaryAmmoniumGroupTransport',s("The","directed","movement","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","of","quaternary","ammonium","compounds",",","any","compound","that","can","be","regarded","as","derived","from","ammonium","hydroxide","or","an","ammonium","salt","by","replacement","of","all","four","hydrogen","atoms","of","the","NH4","+","ion","by","organic","groups","."),4228702). assertion_content_comment('tOboGo_QuercitrinaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","quercitrin","=","L-rhamnose","+","quercetin","."),4263669). assertion_content_comment('tOboGo_QuestinMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADPH","+","O","(","2",")","+","questin","=","demethylsulochrin","+","NADP","(","+",")"),4263658). assertion_content_comment('tOboGo_QueuineSynthaseActivity',s("Catalysis","of","the","reaction",":","7-aminomethyl-7-deazaguanine","+","2","NADP","(","+",")","=","7-cyano-7-deazaguanine","+","3","H","(","+",")","+","2","NADPH","."),4342419). assertion_content_comment('tOboGo_QueuosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","queuosines",",","any","of","a","series","of","nucleosides","found","in","tRNA","and","having","an","additional","pentenyl","ring","added","via","an","NH","group","to","the","methyl","group","of","7-methylguanosine",".","The","pentenyl","ring","may","carry","other","substituents","."),4253096). assertion_content_comment('tOboGo_QueuosineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","queuosines",",","any","of","a","series","of","nucleosides","found","in","tRNA","and","having","an","additional","pentenyl","ring","added","via","an","NH","group","to","the","methyl","group","of","7-methylguanosine",".","The","pentenyl","ring","may","carry","other","substituents","."),4352372). assertion_content_comment('tOboGo_QueuosineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","queuosines",",","any","of","a","series","of","nucleosides","found","in","tRNA","and","having","an","additional","pentenyl","ring","added","via","an","NH","group","to","the","methyl","group","of","7-methylguanosine",".","The","pentenyl","ring","may","carry","other","substituents","."),4253077). assertion_content_comment('tOboGo_QuinateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","quinate",",","the","anion","of","quinic","acid","."),4313563). assertion_content_comment('tOboGo_QuinateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","quinate",",","the","anion","of","quinic","acid","."),4244001). assertion_content_comment('tOboGo_QuinateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","quinate",",","the","anion","of","quinic","acid",".","The","acid","occurs","commonly","in","plants",",","either","free","or","as","esters",",","and","is","used","as","a","medicine","."),4243987). assertion_content_comment('tOboGo_QuinateShikimateDehydrogenaseActivity',s("Catalysis","of","the","reactions",":","L-quinate","+","NAD","(","P",")","+","=","3-dehydroquinate","+","NAD","(","P",")","H","+","H","+",",","and","shikimate","+","NAD","(","P",")","+","=","3-dehydroshikimate","+","NAD","(","P",")","H","+","H","+"),4341811). assertion_content_comment('tOboGo_QuinolinateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","quinolinate",",","the","anion","of","quinolinic","acid",",","also","known","as","2",",","3-pyridinedicarboxylic","acid","."),4233441). assertion_content_comment('tOboGo_QuinolinateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","quinolinate",",","the","anion","of","quinolinic","acid",",","also","known","as","2",",","3-pyridinedicarboxylic","acid","."),4359764). assertion_content_comment('tOboGo_QuinolinateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","quinolinate",",","the","anion","of","quinolinic","acid",",","also","known","as","2",",","3-pyridinedicarboxylic","acid","."),4233438). assertion_content_comment('tOboGo_QuinolinateSynthetaseAActivity',s("Catalysis","of","the","reaction",":","iminoaspartate","+","dihydroxy-acetone-phosphate","=","quinolinate","+","2","H2O","+","phosphate","."),4233478). assertion_content_comment('tOboGo_QuinolinateSynthetaseComplex',s("OBSOLETE",".","A","heterodimer","which","acts","as","a","quinolinate","synthetase",";","quinolinate","synthetase","B","(","L-aspartate","oxidase",")","catalyzes","the","oxidation","of","L-aspartate","to","L-iminoaspartate",";","quinolinate","synthetase","A","condenses","L-imidoaspartate","and","dihydroxyacetone","to","quinolinate","."),4233481). assertion_content_comment('tOboGo_QuinoneBinding',s("Interacting","selectively","and","non-covalently","with","a","quinone",",","any","member","of","a","class","of","diketones","derivable","from","aromatic","compounds","by","conversion","of","two","CH","groups","into","CO","groups","with","any","necessary","rearrangement","of","double","bonds","."),4178027). assertion_content_comment('tOboGo_QuinoneCofactorBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","quinone","cofactor",",","such","as","menaquinone","(","vitamin","K2",")",",","ubiquinone","(","coenzyme","Q",")","or","phylloquinone","(","vitamin","K1",")"),4025676). assertion_content_comment('tOboGo_QuinoneCofactorCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","quinone","cofactors","."),4312635). assertion_content_comment('tOboGo_QuinoneCofactorMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","quinone","cofactors","."),4025639). assertion_content_comment('tOboGo_QuinoneCofactorMethyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosylmethionine","during","the","synthesis","of","quinone","cofactors","such","as","ubiquinone","(","coenzyme","Q",")",",","menaquinone","(","vitamin","K2",")",",","plastoquinone","and","phylloquinone","(","vitamin","K1",")"),4253521). assertion_content_comment('tOboGo_QuinoproteinGlucoseDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","D-glucose","+","ubiquinone","=","D-glucono-1",",","5-lactone","+","ubiquinol","."),4249754). assertion_content_comment('tOboGo_QuorumSensingInvolvedInInteractionWithHost',s("The","process","in","which","a","community","of","single-celled","organisms","living","in","intimate","contact","with","a","host","organism","monitors","population","density","by","detecting","the","concentration","of","small","diffusible","signal","molecules",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121255). assertion_content_comment('tOboGo_QuorumSensing',s("The","process","in","which","single-celled","organisms","monitor","their","population","density","by","detecting","the","concentration","of","small",",","diffusible","signal","molecules","produced","by","the","cells","themselves","."),4026585). assertion_content_comment('tOboGo_R1R6CellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","the","specialized","features","of","R1","and","R6","photoreceptors",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4017886). assertion_content_comment('tOboGo_R1R6CellFateCommitment',s("The","process","in","which","the","R1/R6","photoreceptors","commit","to","their","cell","fate",".","R1","and","R6","are","paired","photoreceptors","which","contribute","the","outer","rhabdomeres","."),4017896). assertion_content_comment('tOboGo_R1R6Development',s("The","process","whose","specific","outcome","is","the","progression","of","the","R1","and","R6","pair","of","photoreceptors","in","the","eye","over","time",",","from","their","formation","to","the","mature","structures",".","R1","and","R6","are","paired","photoreceptors","that","contribute","to","the","outer","rhabdomeres",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4104569). assertion_content_comment('tOboGo_R2R5CellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","the","specialized","features","of","R2","and","R5","photoreceptors",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4017814). assertion_content_comment('tOboGo_R2R5CellFateCommitment',s("The","process","in","which","the","R2/R5","photoreceptors","commit","to","their","cell","fate",".","R2","and","R5","are","paired","photoreceptors","which","contribute","the","outer","rhabdomeres","."),4017824). assertion_content_comment('tOboGo_R2R5Development',s("The","process","whose","specific","outcome","is","the","progression","of","the","R2","and","R5","pair","of","photoreceptors","in","the","eye","over","time",",","from","their","formation","to","the","mature","structures",".","R2","and","R5","are","paired","photoreceptors","that","contribute","to","the","outer","rhabdomeres",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4104579). assertion_content_comment('tOboGo_R3R4CellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","the","specialized","features","of","R3","and","R4","photoreceptors",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4017854). assertion_content_comment('tOboGo_R3R4CellFateCommitment',s("The","process","in","which","the","R3/R4","photoreceptors","commit","to","their","cell","fate",".","R3","and","R4","are","paired","photoreceptors","which","contribute","the","outer","rhabdomeres","."),4017856). assertion_content_comment('tOboGo_R3R4Development',s("The","process","whose","specific","outcome","is","the","progression","of","the","R3","and","R4","pair","of","photoreceptors","in","the","eye","over","time",",","from","their","formation","to","the","mature","structures",".","R3","and","R4","are","paired","photoreceptors","that","contribute","to","the","outer","rhabdomeres",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4104559). assertion_content_comment('tOboGo_R7CellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","R7","photoreceptor","over","time",",","from","its","formation","to","the","mature","structure",".","The","R7","photoreceptor","is","the","last","photoreceptor","to","develop","in","the","ommatidium","."),4089450). assertion_content_comment('tOboGo_R7CellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","the","R7","photoreceptor","."),4017938). assertion_content_comment('tOboGo_R7CellFateCommitment',s("The","process","in","which","the","R7","photoreceptor","commits","to","its","cell","fate",".","The","R7","receptor","contributes","the","central","part","of","the","rhabdomere","in","the","apical","parts","of","the","ommatidium","."),4017948). assertion_content_comment('tOboGo_R8CellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","R8","photoreceptor","over","time",",","from","its","formation","to","the","mature","structure",".","The","R8","photoreceptor","is","the","founding","receptor","of","each","ommatidium","."),4089440). assertion_content_comment('tOboGo_R8CellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","the","R8","photoreceptor","."),4017865). assertion_content_comment('tOboGo_R8CellFateCommitment',s("The","process","in","which","the","R8","photoreceptor","commits","to","its","cell","fate",".","The","R8","receptor","contributes","the","central","part","of","the","rhabdomere","in","the","basal","parts","of","the","ommatidium","."),4017876). assertion_content_comment('tOboGo_R8CellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","R8","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4089460). assertion_content_comment('tOboGo_RabGeranylgeranyltransferaseActivity',s("Catalysis","of","the","reaction",":","2","geranylgeranyl","diphosphate","+","protein-cysteine","=","2","S-geranylgeranyl-protein","+","2","diphosphate",".","This","reaction","is","the","formation","of","two","thioether","linkages","between","the","C-1","atom","of","the","geranylgeranyl","groups","and","two","cysteine","residues","within","the","terminal","sequence","motifs","XXCC",",","XCXC","or","CCXX",".","Known","substrates","include","Ras-related","GTPases","of","a","single","family","and","the","Rab","family","."),4202436). assertion_content_comment('tOboGo_RabGTPaseActivatorActivity',s("Increases","the","rate","of","GTP","hydrolysis","by","a","GTPase","of","the","Rab","family","."),4215269). assertion_content_comment('tOboGo_RabGTPaseBinding',s("Interacting","selectively","and","non-covalently","with","Rab","protein",",","any","member","of","the","Rab","subfamily","of","the","Ras","superfamily","of","monomeric","GTPases","."),4257928). assertion_content_comment('tOboGo_RabProteinSignalTransduction',s("A","series","of","molecular","signals","within","the","cell","that","are","mediated","by","a","member","of","the","Rab","family","of","proteins","switching","to","a","GTP-bound","active","state","."),4055824). assertion_content_comment('tOboGo_RABSmallMonomericGTPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate","."),4185583). assertion_content_comment('tOboGo_RacemaseAndEpimeraseActivityActingOnAminoAcidsAndDerivatives',s("Catalysis","of","a","reaction","that","alters","the","configuration","of","one","or","more","chiral","centers","in","an","amino","acid","."),4249162). assertion_content_comment('tOboGo_RacemaseAndEpimeraseActivityActingOnCarbohydratesAndDerivatives',s("Catalysis","of","a","reaction","that","alters","the","configuration","of","one","or","more","chiral","centers","in","a","carbohydrate","molecule","."),4186772). assertion_content_comment('tOboGo_RacemaseAndEpimeraseActivityActingOnHydroxyAcidsAndDerivatives',s("Catalysis","of","a","reaction","that","alters","the","configuration","of","one","or","more","chiral","centers","in","a","hydroxy","acid","molecule","."),4250616). assertion_content_comment('tOboGo_RacemaseAndEpimeraseActivityActingOnOtherCompounds',s("OBSOLETE",".","Racemase","and","epimerase","activity","on","compounds","other","than","amino","acids",",","hydroxy","acids",",","carbohydrates","or","their","derivatives","."),4301782). assertion_content_comment('tOboGo_RacemaseAndEpimeraseActivity',s("Catalysis","of","a","reaction","that","alters","the","configuration","of","one","or","more","chiral","centers","in","a","molecule","."),4186769). assertion_content_comment('tOboGo_RacGTPaseActivatorActivity',s("Increases","the","rate","of","GTP","hydrolysis","by","a","GTPase","of","the","Rac","family","."),4308261). assertion_content_comment('tOboGo_RacGTPaseBinding',s("Interacting","selectively","and","non-covalently","with","Rac","protein",",","any","member","of","the","Rac","subfamily","of","the","Ras","superfamily","of","monomeric","GTPases","."),4334570). assertion_content_comment('tOboGo_RacProteinSignalTransduction',s("A","series","of","molecular","signals","within","the","cell","that","are","mediated","by","a","member","of","the","Rac","family","of","proteins","switching","to","a","GTP-bound","active","state","."),4056398). assertion_content_comment('tOboGo_RadialAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","an","axis","that","initiates","at","a","point","and","radiates","outward","from","the","point","."),4033212). assertion_content_comment('tOboGo_RadialGliaGuidedMigrationOfCerebellarGranuleCell',s("The","inward","migration","of","postmitotic","granule","cells","along","a","radial","glial","cell","from","the","external","granule","layer","to","the","internal","granule","cell","layer","."),4047976). assertion_content_comment('tOboGo_RadialGliaGuidedMigrationOfPurkinjeCell',s("The","migration","of","postmitotic","a","Purkinje","cell","along","radial","glial","cells","from","the","ventricular","zone","to","the","Purkinje","cell","layer","."),4047861). assertion_content_comment('tOboGo_RadialGlialCellDifferentiation',s("The","process","in","which","neuroepithelial","cells","of","the","neural","tube","give","rise","to","radial","glial","cells",",","specialized","bipotential","progenitors","cells","of","the","brain",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","."),4050764). assertion_content_comment('tOboGo_RadialGlialCellDivisionInForebrain',s("The","mitotic","division","of","radial","glial","cells","in","the","developing","forebrain","."),4047270). assertion_content_comment('tOboGo_RadialGlialCellDivisionInPallium',s("The","division","of","a","radial","glial","cell","in","the","pallium",".","A","radial","glial","cell","is","a","precursor","cell","that","gives","rise","to","neurons","and","astrocytes","."),4053472). assertion_content_comment('tOboGo_RadialGlialCellDivisionInSubpallium',s("The","division","of","a","radial","glial","cell","in","the","subpallium",".","A","radial","glial","cell","is","a","precursor","cell","that","gives","rise","to","neurons","and","astrocytes","."),4053287). assertion_content_comment('tOboGo_RadialGlialCellFateCommitmentInForebrain',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","radial","glial","cell","in","the","forebrain","."),4053461). assertion_content_comment('tOboGo_RadialGrowthInvolvedInRightVentricleMorphogenesis',s("The","morphogenic","growth","in","which","the","right","ventricle","grows","along","a","radial","axis","."),4002765). assertion_content_comment('tOboGo_RadialMicrotubularSystemFormation',s("Formation","of","radial","microtubular","systems","during","male","meiotic","cytokinesis","in","plants","."),4335548). assertion_content_comment('tOboGo_RadialPatternFormation',s("The","regionalization","process","that","results","in","defined","areas","around","a","point","in","which","specific","types","of","cell","differentiation","will","occur","."),4022159). assertion_content_comment('tOboGo_RadialSpokehead',s("Protein","complex","forming","part","of","eukaryotic","flagellar","apparatus","."),3981934). assertion_content_comment('tOboGo_RadialSpoke',s("Protein","complex","that","links","the","outer","microtubule","doublet","of","the","ciliary","or","flagellum","axoneme","with","the","sheath","that","surrounds","the","central","pair","of","microtubules",".","Composed","of","a","stalk","that","attaches","to","each","doublet","microtubule","and","a","globular","structure","(","spoke","head",")","that","projects","toward","the","central","pair","of","microtubules","."),3981912). assertion_content_comment('tOboGo_RadialSpokeStalk',s("Globular","portion","of","the","radial","spoke","that","projects","towards","the","central","pair","of","microtubules","."),3981923). assertion_content_comment('tOboGo_RadicalSAMEnzymeActivity',s("Catalysis","of","a","reaction","in","which","S-adenosyl-L-methionine","(","SAM",")","undergoes","reductive","cleavage","to","serve","as","a","source","of","the","5","'","-deoxyadenosyl","radical","."),4174286). assertion_content_comment('tOboGo_RaffinoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","raffinose",",","the","trisaccharide","beta-D-fructofuranosyl","alpha-D-galactopyranosyl-","(","1-","&","gt",";","6",")","-alpha-D-glucopyranoside","."),4340847). assertion_content_comment('tOboGo_RaffinoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","raffinose",",","the","trisaccharide","beta-D-fructofuranosyl","alpha-D-galactopyranosyl-","(","1-","&","gt",";","6",")","-alpha-D-glucopyranoside","."),4357534). assertion_content_comment('tOboGo_RaffinoseFamilyOligosaccharideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","raffinose","family","oligosaccharides","(","RFOs",",","such","as","raffinose",",","stachyose",",","verbascose","and","other","molecules","with","a","higher","degree","of","galactosyl","polymerization",")"),4332551). assertion_content_comment('tOboGo_Raffinose_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","raffinose","(","out",")","+","H","+","(","out",")","=","raffinose","(","in",")","+","H","+","(","in",")"),4293062). assertion_content_comment('tOboGo_RaffinoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","raffinose",",","the","trisaccharide","beta-D-fructofuranosyl","alpha-D-galactopyranosyl-","(","1-","&","gt",";","6",")","-alpha-D-glucopyranoside","."),4147615). assertion_content_comment('tOboGo_RaffinoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","raffinose","from","one","side","of","the","membrane","to","the","other",".","Raffinose","occurs","in","plants","almost","as","commonly","as","sucrose","and","is","present","in","cereal","grains",",","cotton","seeds",",","and","many","legumes",".","It","is","synthesized","from","sucrose","by","transfer","of","a","galactopyranoside","from","myo-inositol","."),4293059). assertion_content_comment('tOboGo_RaffinoseTransport',s("The","directed","movement","of","raffinose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Raffinose","occurs","in","plants","almost","as","commonly","as","sucrose","and","is","present","in","cereal","grains",",","cotton","seeds",",","and","many","legumes",".","It","is","synthesized","from","sucrose","by","transfer","of","a","galactopyranoside","from","myo-inositol","."),4291262). assertion_content_comment('tOboGo_RAGEReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","RAGE","receptor",",","the","receptor","for","advanced","glycation","end-products","."),4275477). assertion_content_comment('tOboGo_RagulatorComplex',s("A","protein","complex","that","contains","MAPKSP1","(","MP1",",","Map2k1ip1",")",",","ROBLD3","(","p14",",","Mapbpip",")",",","and","C11orf59","(","p18",")","The","complex","is","anchored","to","lipid","rafts","in","late","endosome","membranes","via","C11orf59",",","recruits","mTORC1","to","lysosomal","membranes","in","amino","acid","signaling","to","mTORC1",",","and","is","also","involved","in","ERK/MAPK","signaling","."),4125760). assertion_content_comment('tOboGo_RalGTPaseActivatorActivity',s("Increases","the","rate","of","GTP","hydrolysis","by","a","GTPase","of","the","Ral","family","."),4267539). assertion_content_comment('tOboGo_RalGTPaseBinding',s("Interacting","selectively","and","non-covalently","with","Ral","protein",",","any","member","of","the","Ral","subfamily","of","the","Ras","superfamily","of","monomeric","GTPases","."),4257907). assertion_content_comment('tOboGo_RalProteinSignalTransduction',s("A","series","of","molecular","signals","within","the","cell","that","are","mediated","by","a","member","of","the","Ral","family","of","proteins","switching","to","a","GTP-bound","active","state","."),4055843). assertion_content_comment('tOboGo_RandomCoilBinding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4222507). assertion_content_comment('tOboGo_RandomCoilDNABinding',s("Interacting","selectively","and","non-covalently","with","DNA","in","a","random","coil","configuration","."),4193394). assertion_content_comment('tOboGo_RandomInactivationOfXChromosome',s("Compensating","for","the","two-fold","variation","in","X-chromosome",":","autosome","ratios","between","sexes","by","a","global","inactivation","of","all",",","or","most","of",",","the","genes","on","either","the","paternal","or","maternal","X-chromosome","in","the","XX","sex","."),4156384). assertion_content_comment('tOboGo_RanGTPaseActivatorActivity',s("Increases","the","rate","of","GTP","hydrolysis","by","a","GTPase","of","the","Ran","family","."),4215258). assertion_content_comment('tOboGo_RanGTPaseBinding',s("Interacting","selectively","and","non-covalently","with","Ran",",","a","conserved","Ras-like","GTP-binding","protein",",","implicated","in","nucleocytoplasmic","transport",",","cell","cycle","progression",",","spindle","assembly",",","nuclear","organization","and","nuclear","envelope","(","NE",")","assembly","."),4220268). assertion_content_comment('tOboGo_RanProteinSignalTransduction',s("A","series","of","molecular","signals","within","the","cell","that","are","mediated","by","a","member","of","the","Ran","family","of","proteins","switching","to","a","GTP-bound","active","state","."),4056277). assertion_content_comment('tOboGo_RANSmallMonomericGTPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate","."),4185595). assertion_content_comment('tOboGo_RapGTPaseActivatorActivity',s("Increases","the","rate","of","GTP","hydrolysis","by","a","GTPase","of","the","Rap","family","."),4358686). assertion_content_comment('tOboGo_RapProteinSignalTransduction',s("A","series","of","molecular","signals","within","the","cell","that","are","mediated","by","a","member","of","the","Rap","family","of","proteins","switching","to","a","GTP-bound","active","state","."),4055862). assertion_content_comment('tOboGo_RasGTPaseActivatorActivity',s("Increases","the","rate","of","GTP","hydrolysis","by","a","GTPase","of","the","Ras","superfamily","."),4214252). assertion_content_comment('tOboGo_RasGTPaseBinding',s("Interacting","selectively","and","non-covalently","with","any","member","of","the","Ras","superfamily","of","monomeric","GTPases","."),4220265). assertion_content_comment('tOboGo_RasPalmitoyltransferaseActivity',s("Catalysis","of","the","reaction",":","palmitoyl-CoA","+","protein-cysteine","=","S-palmitoyl","protein","+","CoA",",","specific","for","Ras","proteins","."),4326907). assertion_content_comment('tOboGo_RasProteinSignalTransduction',s("A","series","of","molecular","signals","within","the","cell","that","are","mediated","by","a","member","of","the","Ras","superfamily","of","proteins","switching","to","a","GTP-bound","active","state","."),4055725). assertion_content_comment('tOboGo_RASSmallMonomericGTPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate","."),4185500). assertion_content_comment('tOboGo_RAVEComplex',s("A","multisubunit","complex","that","in","Saccharomyces","is","composed","of","three","subunits",",","Rav1p",",","Rav2p","and","Skp1p",".","Acts","transiently","to","catalyze","assembly","of","cytoplasmic","V1",",","with","membrane","embedded","V0","to","form","the","V-ATPase","holoenzyme","."),4318510). assertion_content_comment('tOboGo_RCAFComplex',s("A","protein","complex","that","facilitates","the","assembly","of","nucleosomes","on","to","newly","synthesized","DNA",".","In","Drosophila",",","the","complex","comprises","ASF1","and","histones","H3","and","H4","."),4381858). assertion_content_comment('tOboGo_RDNABinding',s("Interacting","selectively","and","non-covalently","with","DNA","sequences","encoding","ribosomal","RNA","."),4182404). assertion_content_comment('tOboGo_RDNACondensation',s("The","cell","cycle","process","in","which","the","chromatin","structure","of","the","rDNA","repeats","is","compacted",".","In","S",".","cerevisiae",",","condensation","and","resolution","of","the","rDNA","occurs","during","anaphase","."),4174738). assertion_content_comment('tOboGo_RDNAHeterochromatin',s("A","region","of","heterochromatin","located","at","the","rDNA","repeats","in","a","chromosome","."),4341037). assertion_content_comment('tOboGo_RDNAProtrusion',s("Any","of","the","tandem","arrays","of","rDNA","localized","at","the","periphery","of","the","nucleus","and","protruding","into","the","nucleolus",",","and","associated","proteins",".","May","be","visible","as","a","single","or","double","spot","by","DAPI","staining","."),4061863). assertion_content_comment('tOboGo_RDNASeparation',s("The","cell","cycle","process","in","which","rDNA","repeat","regions","are","physically","detached","from","each","other","during","chromosome","separation","."),4074809). assertion_content_comment('tOboGo_RDNASpacerReplicationForkBarrierBinding',s("Interacting","selectively","and","non-covalently","with","replication","fork","barriers","found","in","rDNA","spacers",",","sites","that","inhibit","replication","forks","in","the","direction","opposite","to","rDNA","transcription","."),4317712). assertion_content_comment('tOboGo_ReactivationOfLatentVirus',s("The","reactivation","of","a","virus","from","a","latent","to","a","lytic","state","."),4045178). assertion_content_comment('tOboGo_ReactiveOxygenSpeciesMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","reactive","oxygen","species",",","any","molecules","or","ions","formed","by","the","incomplete","one-electron","reduction","of","oxygen",".","They","contribute","to","the","microbicidal","activity","of","phagocytes",",","regulation","of","signal","transduction","and","gene","expression",",","and","the","oxidative","damage","to","biopolymers","."),4024239). assertion_content_comment('tOboGo_ReceptionOfAnInductiveSignal',s("The","process","in","which","one","cell","or","group","of","cells","receives",",","transduces",",","and","responds","to","a","signal","generated","by","another","cell","or","group","of","cells","of","different","ancestry","and","developmental","potential",",","such","that","the","recipient","cell","(","s",")","undergo","a","developmental","change","."),4062587). assertion_content_comment('tOboGo_ReceptorActivatorActivity',s("The","function","of","interacting","(","directly","or","indirectly",")","with","receptors","such","that","the","proportion","of","receptors","in","the","active","form","is","increased","."),4170822). assertion_content_comment('tOboGo_ReceptorActivity',s("Combining","with","an","extracellular","or","intracellular","messenger","to","initiate","a","change","in","cell","activity","."),4071552). assertion_content_comment('tOboGo_ReceptorAgonistActivity',s("Interacts","with","receptors","such","that","the","proportion","of","receptors","in","the","active","form","is","increased","."),4384728). assertion_content_comment('tOboGo_ReceptorAntagonistActivity',s("Interacts","with","receptors","to","reduce","the","action","of","another","ligand",",","the","agonist","."),4217495). assertion_content_comment('tOboGo_ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","one","or","more","specific","sites","on","a","receptor","molecule",",","a","macromolecule","that","undergoes","combination","with","a","hormone",",","neurotransmitter",",","drug","or","intracellular","messenger","to","initiate","a","change","in","cell","function","."),4052580). assertion_content_comment('tOboGo_ReceptorBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","receptor","molecule",",","a","macromolecule","that","undergoes","combination","with","a","hormone",",","neurotransmitter",",","drug","or","intracellular","messenger","to","initiate","a","change","in","cell","function","."),4037182). assertion_content_comment('tOboGo_ReceptorCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","receptor","molecule",",","a","macromolecule","that","undergoes","combination","with","a","hormone",",","neurotransmitter",",","drug","or","intracellular","messenger","to","initiate","a","change","in","cell","function","."),4070389). assertion_content_comment('tOboGo_ReceptorClustering',s("The","receptor","metabolic","process","that","results","in","grouping","of","a","set","of","receptors","at","a","cellular","location",",","often","to","amplify","the","sensitivity","of","a","signaling","response","."),4092859). assertion_content_comment('tOboGo_ReceptorComplex',s("Any","protein","complex","that","undergoes","combination","with","a","hormone",",","neurotransmitter",",","drug","or","intracellular","messenger","to","initiate","a","change","in","cell","function","."),4007365). assertion_content_comment('tOboGo_ReceptorGuanylateCyclaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","=","3","'",",","5","'","-cyclic","GMP","+","diphosphate","."),4247221). assertion_content_comment('tOboGo_ReceptorGuanylylCyclaseSignalingPathway',s("Any","series","of","molecular","signals","initiated","by","the","binding","of","an","extracellular","ligand","to","a","receptor","on","the","surface","of","the","target","cell",",","where","the","receptor","possesses","guanylyl","cyclase","activity","."),4236209). assertion_content_comment('tOboGo_ReceptorInhibitorActivity',s("The","function","of","interacting","(","directly","or","indirectly",")","with","receptors","such","that","the","proportion","of","receptors","in","the","active","form","is","decreased","."),4217413). assertion_content_comment('tOboGo_ReceptorInternalizationInvolvedInCanonicalWntReceptorSignalingPathway',s("A","receptor","internalization","process","that","contributes","to","canonical","Wnt","receptor","signaling","pathway","."),4140038). assertion_content_comment('tOboGo_ReceptorInternalization',s("A","receptor-mediated","endocytosis","process","that","results","in","the","movement","of","receptors","from","the","plasma","membrane","to","the","inside","of","the","cell",".","The","process","begins","when","cell","surface","receptors","are","monoubiquitinated","following","ligand-induced","activation",";","receptors","are","subsequently","taken","up","into","endocytic","vesicles","and","targeted","to","the","lysosome","or","vacuole","for","degradation",".","Receptor","internalization","serves","as","a","mechanism","to","downregulate","receptor","signaling","."),3989825). assertion_content_comment('tOboGo_ReceptorMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","receptor","molecule",",","a","macromolecule","that","undergoes","combination","with","a","hormone",",","neurotransmitter",",","drug","or","intracellular","messenger","to","initiate","a","change","in","cell","function","."),3986542). assertion_content_comment('tOboGo_ReceptorPorinActivity',s("OBSOLETE",".","A","porin","of","the","bacterial","outer","membrane","that","forms","transmembrane","pores","and","transports","relatively","large","molecules","from","the","external","milieu","to","the","periplasm","in","an","energized","process",".","Energizing","of","transport","across","the","outer","membrane","requires","a","heterotrimeric","complex","of","proteins",",","the","TonB-ExbB-ExbD","complex",",","or","in","some","cases",",","the","TolA-TolQ-TolR","complex",".","Energizing","requires","proton","motive","force","across","the","cytoplasmic","membrane","."),4292392). assertion_content_comment('tOboGo_ReceptorRecycling',s("The","process","that","results","in","the","return","of","receptor","molecules","to","an","active","state","and","an","active","cellular","location","after","they","have","been","stimulated","by","a","ligand",".","An","active","state","is","when","the","receptor","is","ready","to","receive","a","signal","."),3986546). assertion_content_comment('tOboGo_ReceptorRegulatorActivity',s("The","function","of","interacting","(","directly","or","indirectly",")","with","receptors","such","that","the","proportion","of","receptors","in","the","active","form","is","changed","."),4170820). assertion_content_comment('tOboGo_ReceptorSerineThreonineKinaseBinding',s("Interacting","selectively","and","non-covalently","with","a","receptor","that","possesses","protein","serine/threonine","kinase","activity","."),4176503). assertion_content_comment('tOboGo_ReceptorSignalingComplexScaffoldActivity',s("Functions","to","provide","a","physical","support","for","the","assembly","of","a","multiprotein","receptor","signaling","complex","."),4311273). assertion_content_comment('tOboGo_ReceptorSignalingProteinActivity',s("Conveys","a","signal","from","an","upstream","receptor","or","intracellular","signal","transducer",",","converting","the","signal","into","a","form","where","it","can","ultimately","trigger","a","change","in","the","state","or","activity","of","a","cell","."),4200559). assertion_content_comment('tOboGo_ReceptorSignalingProteinSerineThreonineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","receptor","signaling","protein","serine","=","ADP","+","receptor","signaling","protein","serine","phosphate",",","and","ATP","+","receptor","signaling","protein","threonine","=","ADP","+","receptor","signaling","protein","threonine","phosphate","."),4200562). assertion_content_comment('tOboGo_ReceptorSignalingProteinSerineThreonineKinaseSignalingProteinActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4215330). assertion_content_comment('tOboGo_ReceptorSignalingProteinSerineThreoninePhosphataseActivity',s("Catalysis","of","the","reactions",":","receptor","signaling","protein","serine","phosphate","+","H2O","=","receptor","signaling","protein","serine","+","phosphate",";","and","receptor","signaling","protein","threonine","phosphate","+","H2O","=","receptor","signaling","protein","threonine","+","phosphate","."),4258516). assertion_content_comment('tOboGo_ReceptorSignalingProteinSerineThreoninePhosphataseSignalingProteinActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4215487). assertion_content_comment('tOboGo_ReceptorSignalingProteinTyrosineKinaseActivatorActivity',s("Increases","the","activity","of","a","receptor","signaling","protein","tyrosine","kinase","."),4311821). assertion_content_comment('tOboGo_ReceptorSignalingProteinTyrosineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","receptor","signalling","protein","tyrosine","=","ADP","+","receptor","signalling","protein","phosphate","."),4201051). assertion_content_comment('tOboGo_ReceptorSignalingProteinTyrosineKinaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","receptor","signaling","protein","tyrosine","kinase","."),4311831). assertion_content_comment('tOboGo_ReceptorSignalingProteinTyrosineKinaseSignalingProteinActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4256178). assertion_content_comment('tOboGo_ReceptorSignalingProteinTyrosinePhosphataseActivity',s("Catalysis","of","the","reaction",":","receptor","signaling","protein","tyrosine","phosphate","+","H2O","=","receptor","signaling","protein","tyrosine","+","phosphate","."),4200906). assertion_content_comment('tOboGo_ReceptorSignalingProteinTyrosinePhosphataseSignalingProteinActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4215500). assertion_content_comment('tOboGo_ReceptorTransactivation',s("The","process","in","which","a","receptor","is","activated","via","signaling","events","from","a","receptor","for","a","different","ligand",".","Receptor","transactivation","is","an","example","of","cross-talk","between","signaling","pathways","and","can","occur","through","several","different","mechanisms","."),4379745). assertion_content_comment('tOboGo_ReceptorTyrosineKinaseBinding',s("Interacting","selectively","and","non-covalently","with","a","receptor","that","possesses","protein","tyrosine","kinase","activity","."),4214991). assertion_content_comment('tOboGo_RecFORComplex',s("A","heterotrimeric","complex","composed","of","the","subunits","RecF",",","RecO","and","RecR",".","Mediates","the","loading","of","RecA","protein","specifically","onto","SSB-coated","gapped","DNA","during","DNA","repair","."),4326897). assertion_content_comment('tOboGo_ReciprocalMeioticRecombination',s("The","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate",".","This","results","in","the","equal","exchange","of","genetic","material","between","non-sister","chromatids","in","a","pair","of","homologous","chromosomes",".","These","reciprocal","recombinant","products","ensure","the","proper","segregation","of","homologous","chromosomes","during","meiosis","I","and","create","genetic","diversity","."),3977017). assertion_content_comment('tOboGo_RecognitionOfApoptoticCell',s("The","process","in","which","a","cell","interprets","signals","(","in","the","form","of","specific","proteins","and","lipids",")","on","the","surface","of","a","dying","cell","which","it","will","engulf","and","remove","by","phagocytosis","."),4094972). assertion_content_comment('tOboGo_RecognitionOfHost',s("The","set","of","specific","processes","that","allow","an","organism","to","detect","the","presence","of","its","host","via","physical","or","chemical","signals",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4287699). assertion_content_comment('tOboGo_RecognitionOfOtherOrganismInvolvedInSymbioticInteraction',s("The","set","of","specific","processes","that","allow","an","organism","to","detect","the","presence","of","a","second","organism","via","physical","or","chemical","signals",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4122305). assertion_content_comment('tOboGo_RecognitionOfPollen',s("The","process",",","involving","the","sharing","and","interaction","of","the","single","locus","incompatibility","haplotypes",",","involved","in","the","recognition","or","rejection","of","the","self","pollen","by","cells","in","the","stigma",".","This","process","ensures","out-breeding","in","certain","plant","species","."),4103038). assertion_content_comment('tOboGo_RecognitionOfSymbiont',s("The","set","of","specific","processes","that","allow","an","organism","to","detect","the","presence","of","its","symbiont","via","physical","or","chemical","signals",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282477). assertion_content_comment('tOboGo_RecombinaseActivity',s("Catalysis","of","the","identification","and","base-pairing","of","homologous","sequences","between","single-stranded","DNA","and","double-stranded","DNA","."),4346139). assertion_content_comment('tOboGo_RecombinationalRepair',s("A","DNA","repair","process","that","involves","the","exchange",",","reciprocal","or","nonreciprocal",",","of","genetic","material","between","the","broken","DNA","molecule","and","a","homologous","region","of","DNA","."),3977253). assertion_content_comment('tOboGo_RecombinationHotspotBinding',s("Interacting","selectively","and","non-covalently","with","a","region","in","a","genome","which","promotes","recombination","."),4335867). assertion_content_comment('tOboGo_RecombinationNodule',s("An","electron","dense","structure","that","is","associated","with","meiotic","chromosomes","."),4007891). assertion_content_comment('tOboGo_RecombinationWithinRDNARepeats',s("Genetic","recombination","within","the","DNA","of","the","genes","coding","for","ribosomal","RNA","."),4299505). assertion_content_comment('tOboGo_RectalDiverticulumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","rectal","diverticulum","over","time",",","from","its","formation","to","the","mature","structure",".","The","rectal","diverticulum","is","an","outgrowth","of","the","cloaca","and","links","the","pronephric","kidney","to","the","exterior","."),4059291). assertion_content_comment('tOboGo_RecyclingEndosomeLumen',s("The","volume","enclosed","by","the","membranes","of","a","recycling","endosome","."),4073227). assertion_content_comment('tOboGo_RecyclingEndosomeMembrane',s("The","lipid","bilayer","surrounding","a","recycling","endosome","."),4107747). assertion_content_comment('tOboGo_RecyclingEndosome',s("Organelle","consisting","of","networks","of","60nm","tubules","organized","around","the","microtubule","organizing","centre","in","some","cell","types",".","They","transport","receptors","from","late","endosomes","back","to","the","plasma","membrane","for","recycling","and","are","also","involved","in","membrane","trafficking","."),4073215). assertion_content_comment('tOboGo_RecyclingEndosomeToGolgiTransport',s("The","directed","movement","of","substances","from","recycling","endosomes","to","the","Golgi","."),4168727). assertion_content_comment('tOboGo_RedChlorophyllCataboliteReductaseActivity',s("Catalysis","of","the","reaction",":","red","chlorophyll","catabolite","+","reduced","ferredoxin","+","2","H","+","=","primary","fluorescent","catabolite","+","oxidized","ferredoxin",".","This","reaction","is","the","reduction","of","the","C20/C1","double","bond","in","the","pyrrole","system","of","red","chlorophyll","catabolite","(","RCC",")","to","a","colorless","tetrapyrrole","(","pFCC",")","with","a","strong","blue","fluorescence","."),4279863). assertion_content_comment('tOboGo_RedLightPhotoreceptorActivity',s("The","function","of","absorbing","and","responding","to","electromagnetic","radiation","with","a","wavelength","of","approximately","660nm",".","The","response","may","involve","a","change","in","conformation","."),4321788). assertion_content_comment('tOboGo_RedLightSignalingPathway',s("The","series","of","molecular","signals","initiated","upon","sensing","of","red","light","by","a","photoreceptor","molecule",".","Red","light","is","electromagnetic","radiation","of","wavelength","of","580-700nm",".","An","example","of","this","response","is","seen","at","the","beginning","of","many","plant","species","developmental","stages",".","These","include","germination",",","and","the","point","when","cotyledon","expansion","is","triggered",".","In","certain","species","these","processes","take","place","in","response","to","absorption","of","red","light","by","the","pigment","molecule","phytochrome",",","but","the","signal","can","be","reversed","by","exposure","to","far","red","light",".","During","the","initial","phase","the","phytochrome","molecule","is","only","present","in","the","red","light","absorbing","form",",","but","on","absorption","of","red","light","it","changes","to","a","far","red","light","absorbing","form",",","triggering","progress","through","development",".","An","immediate","short","period","of","exposure","to","far","red","light","entirely","returns","the","pigment","to","its","initial","state","and","prevents","triggering","of","the","developmental","process",".","A","thirty","minute","break","between","red","and","subsequent","far","red","light","exposure","renders","the","red","light","effect","irreversible",",","and","development","then","occurs","regardless","of","whether","far","red","light","exposure","subsequently","occurs","."),4334220). assertion_content_comment('tOboGo_RedoxTaxis',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","redox","potential","."),4259170). assertion_content_comment('tOboGo_ReducedFolateCarrierActivity',s("Catalysis","of","the","transfer","of","reduced","folate","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4254540). assertion_content_comment('tOboGo_ReductionOfCytosolicCalciumIonConcentration',s("Any","process","that","decreases","the","concentration","of","calcium","ions","in","the","cytodol","."),4286393). assertion_content_comment('tOboGo_ReductionOfEndoplasmicReticulumCalciumIonConcentration',s("Any","process","that","decreases","the","concentration","of","calcium","ions","in","the","endoplasmic","reticulum","."),4283991). assertion_content_comment('tOboGo_ReductionOfFoodIntakeInResponseToDietaryExcess',s("The","specific","actions","of","an","organism","that","are","triggered","by","the","detection","of","dietary","excess","and","result","in","a","decreased","intake","of","food","."),3991007). assertion_content_comment('tOboGo_ReductionOfMitochondrialCalciumIonConcentration',s("Any","process","that","decreases","the","concentration","of","calcium","ions","in","mitochondria","."),4283924). assertion_content_comment('tOboGo_ReductionOfSmoothEndoplasmicReticulumCalciumIonConcentration',s("Any","process","that","decreases","the","concentration","of","calcium","ions","in","the","smooth","endoplasmic","reticulum","."),4283999). assertion_content_comment('tOboGo_ReductionOfVirulence',s("OBSOLETE",".","Any","process","that","stops",",","prevents","or","reduces","the","severity","of","viral","infection","and","subsequent","disease","."),4357858). assertion_content_comment('tOboGo_ReductiveTricarboxylicAcidCycle',s("A","pathway","leading","to","the","fixation","of","two","molecules","of","CO2","and","the","production","of","one","molecule","of","acetyl-CoA",";","essentially","the","oxidative","TCA","cycle","running","in","reverse",".","Acetyl-CoA","is","reductively","carboxylated","to","pyruvate",",","from","which","all","other","central","metabolites","can","be","formed",".","Most","of","the","enzymes","of","reductive","and","oxidative","TCA","cycle","are","shared",",","with","the","exception","of","three","key","enzymes","that","allow","the","cycle","to","run","in","reverse",":","ATP","citrate","lyase",",","2-oxoglutarate",":","ferredoxin","oxidoreductase",",","and","fumarate","reductase",".","2-oxoglutarate",":","ferredoxin","oxidoreductase","catalyzes","the","carboxylation","of","succinyl-CoA","to","2-oxoglutarate",",","ATP","citrate","lyase","the","ATP-dependent","cleavage","of","citrate","to","acetyl-CoA","and","oxaloacetate",",","and","fumarate","reductase","the","reduction","of","fumarate","forming","succinate","."),4244184). assertion_content_comment('tOboGo_Reflex',s("An","automatic","response","to","a","stimulus","beginning","with","a","nerve","impulse","from","a","receptor","and","ending","with","the","action","of","an","effector","such","as","a","gland","or","a","muscle",".","Signaling","never","reaches","a","level","of","consciousness","."),4159236). assertion_content_comment('tOboGo_Regeneration',s("The","regrowth","of","a","lost","or","destroyed","body","part",",","such","as","an","organ","or","tissue","."),4036302). assertion_content_comment('tOboGo_RegionalizationInvolvedInSemicircularCanalFormation',s("The","pattern","specification","process","that","results","in","the","subdivision","of","the","otic","epithelium","in","space","to","define","an","area","or","volume","in","which","cells","will","differentiate","to","give","rise","to","the","semicircular","canals","."),4114025). assertion_content_comment('tOboGo_Regionalization',s("The","pattern","specification","process","that","results","in","the","subdivision","of","an","axis","or","axes","in","space","to","define","an","area","or","volume","in","which","specific","patterns","of","cell","differentiation","will","take","place","or","in","which","cells","interpret","a","specific","environment","."),3985124). assertion_content_comment('tOboGo_RegulatedSecretoryPathway',s("A","process","of","exocytosis","in","which","soluble","proteins","and","other","substances","are","initially","stored","in","secretory","vesicles","for","later","release",".","It","is","found","mainly","in","cells","that","are","specialized","for","secreting","products","such","as","hormones",",","neurotransmitters",",","or","digestive","enzymes","rapidly","on","demand","."),3996371). assertion_content_comment('tOboGo_RegulationByHostOfCytolysisOfSymbiontCells',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","cytolysis","by","that","organism","of","cells","in","its","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4122269). assertion_content_comment('tOboGo_RegulationByOrganismOfEntryIntoOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","to","which","it","enters","into","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109701). assertion_content_comment('tOboGo_RegulationOfAbscisicAcidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","abscisic","acid","."),4032901). assertion_content_comment('tOboGo_RegulationOfAbscisicAcidMediatedSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","abscisic","acid","."),4022479). assertion_content_comment('tOboGo_RegulationOfAcetateCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate",",","the","anion","of","acetic","acid","."),4086612). assertion_content_comment('tOboGo_RegulationOfAcetylcholineMetabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","involving","acetylcholine",",","the","acetic","acid","ester","of","the","organic","base","choline",".","Acetylcholine","is","a","major","neurotransmitter","and","neuromodulator","both","in","the","central","and","peripheral","nervous","systems",".","It","also","acts","as","a","paracrine","signal","in","various","non-neural","tissues","."),4117468). assertion_content_comment('tOboGo_RegulationOfAcetylcholineSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","acetylcholine","."),4039307). assertion_content_comment('tOboGo_RegulationOfAcetylcholineUptake',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","the","neurotransmitter","acetylcholine","into","a","cell","."),4121579). assertion_content_comment('tOboGo_RegulationOfAcrosomalVesicleExocytosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","acrosomal","vesicle","exocytosis","."),4142938). assertion_content_comment('tOboGo_RegulationOfAcrosomeReaction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","acrosome","reaction","."),4109240). assertion_content_comment('tOboGo_RegulationOfActinCorticalPatchLocalization',s("Any","process","that","modulates","the","localization","of","an","actin","cortical","patch",".","An","actin","cortical","patch","is","a","discrete","actin-containing","structure","found","just","beneath","the","plasma","membrane","in","fungal","cells","."),4116909). assertion_content_comment('tOboGo_RegulationOfActinCytoskeletonOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","actin","filaments","and","their","associated","proteins","."),4014740). assertion_content_comment('tOboGo_RegulationOfActinCytoskeletonReorganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","actin","cytoskeleton","reorganization","."),4140419). assertion_content_comment('tOboGo_RegulationOfActinFilamentBundleAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","assembly","of","actin","filament","bundles","."),4054440). assertion_content_comment('tOboGo_RegulationOfActinFilamentDepolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","disassembly","of","actin","filaments","by","the","removal","of","actin","monomers","from","a","filament","."),4050859). assertion_content_comment('tOboGo_RegulationOfActinFilamentLength',s("Any","process","that","controls","the","length","of","actin","filaments","in","a","cell","."),4014743). assertion_content_comment('tOboGo_RegulationOfActinFilamentPolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","assembly","of","actin","filaments","by","the","addition","of","actin","monomers","to","a","filament","."),4050812). assertion_content_comment('tOboGo_RegulationOfActinNucleation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","actin","nucleation",",","the","initial","step","in","the","formation","of","an","actin","filament","in","which","actin","monomers","combine","to","form","a","new","filament","."),4075106). assertion_content_comment('tOboGo_RegulationOfActinPhosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","transfer","of","one","or","more","phosphate","groups","to","an","actin","molecule","."),4094370). assertion_content_comment('tOboGo_RegulationOfActinPolymerizationOrDepolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","assembly","or","disassembly","of","actin","filaments","by","the","addition","or","removal","of","actin","monomers","from","a","filament","."),4014746). assertion_content_comment('tOboGo_RegulationOfActinThinFilamentLengthActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4192925). assertion_content_comment('tOboGo_RegulationOfActionPotentialInNeuron',s("The","process","that","modulates","the","membrane","potential","involved","in","the","propagation","of","a","signal","in","a","neuron","."),4016997). assertion_content_comment('tOboGo_RegulationOfActionPotential',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","action","potential","creation",",","propagation","or","termination",".","An","action","potential","is","a","spike","of","membrane","depolarization","and","repolarization","that","travels","along","the","membrane","of","a","cell","."),4016994). assertion_content_comment('tOboGo_RegulationOfActivatedTCellAutonomousCellDeath',s("Any","process","that","modulates","the","occurrence","or","rate","of","lymphocyte","death","by","apoptosis","."),4137536). assertion_content_comment('tOboGo_RegulationOfActivatedTCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","activated","T","cell","proliferation","."),4080950). assertion_content_comment('tOboGo_RegulationOfActivationOfJAK1KinaseActivity',s("Any","process","that","modulates","the","frequency","or","rate","of","activation","of","JAK1","protein",".","The","activation","of","JAK1","protein","is","the","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK1","(","Janus","Activated","Kinase","1",")","protein",",","thereby","activating","it","."),4027151). assertion_content_comment('tOboGo_RegulationOfActivationOfJAK2KinaseActivity',s("Any","process","that","modulates","the","frequency","or","rate","of","activation","of","JAK2","protein",".","The","activation","of","JAK2","protein","is","the","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK2","(","Janus","Activated","Kinase","2",")","protein",",","thereby","activating","it","."),4027307). assertion_content_comment('tOboGo_RegulationOfActivationOfJanusKinaseActivity',s("Any","process","that","modulates","the","frequency","or","rate","of","activation","of","JAK","protein",".","The","activation","of","JAK","protein","is","the","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK","(","Janus","Activated","Kinase",")","protein",",","thereby","activating","it","."),4027146). assertion_content_comment('tOboGo_RegulationOfActivationOfMembraneAttackComplex',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","activation","of","the","membrane","attack","complex","components","of","the","complement","cascade","."),3987622). assertion_content_comment('tOboGo_RegulationOfActivinReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","activity","of","any","activin","receptor","signaling","pathway","."),4064095). assertion_content_comment('tOboGo_RegulationOfActivinSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","activin","from","a","cell","or","group","of","cells","."),4056161). assertion_content_comment('tOboGo_RegulationOfAcuteInflammatoryResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","acute","inflammatory","response","."),3983209). assertion_content_comment('tOboGo_RegulationOfAcuteInflammatoryResponseToAntigenicStimulus',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","acute","inflammatory","response","to","an","antigenic","stimulus","."),3983244). assertion_content_comment('tOboGo_RegulationOfAdaptiveImmuneResponseBasedOnSomaticRecombinationOfImmuneReceptorsBuiltFromImmunoglobulinSuperfamilyDomains',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","adaptive","immune","response","based","on","somatic","recombination","of","immune","receptors","built","from","immunoglobulin","superfamily","domains",".","An","example","of","this","process","is","found","in","the","Gnathostomata","."),3983326). assertion_content_comment('tOboGo_RegulationOfAdaptiveImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","adaptive","immune","response","."),3983323). assertion_content_comment('tOboGo_RegulationOfAdaxialAbaxialPatternFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","adaxial/abaxial","pattern","formation","."),4139343). assertion_content_comment('tOboGo_RegulationOfAdenosineReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","adenosine","receptor","signaling","pathway",".","The","adenosine","receptor","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","an","adenosine","receptor","binding","to","one","of","its","physiological","ligands","."),4108443). assertion_content_comment('tOboGo_RegulationOfAdenosineTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","adenosine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053914). assertion_content_comment('tOboGo_RegulationOfAdenylateCyclaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","adenylate","cyclase","activity","."),4027766). assertion_content_comment('tOboGo_RegulationOfAdiponectinSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","adiponectin","from","a","cell","or","group","of","cells","."),4133321). assertion_content_comment('tOboGo_RegulationOfAdrenergicReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","an","adrenergic","receptor","signaling","pathway","activity",".","An","adrenergic","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","an","adrenergic","receptor","binding","to","one","of","its","physiological","ligands","."),4125502). assertion_content_comment('tOboGo_RegulationOfAdultSalivaryGlandBoundarySpecification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","salivary","gland","determination","in","an","adult","organism","."),4091339). assertion_content_comment('tOboGo_RegulationOfAeciosporeFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","aeciospore","formation",",","a","process","in","which","a","dikaryotic","spore","of","typically","a","rust","fungus","is","produced","in","an","aecium","."),4148601). assertion_content_comment('tOboGo_RegulationOfAeciumDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","aecium","development",",","a","process","in","which","a","cuplike","structure","containing","chains","of","aeciospores","is","formed","."),4148432). assertion_content_comment('tOboGo_RegulationOfAggregateSizeInvolvedInSorocarpDevelopment',s("Any","process","that","modulates","the","size","of","the","aggregate","formed","during","sorocarp","formation","."),4318886). assertion_content_comment('tOboGo_RegulationOfAggregationInvolvedInSorocarpDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","aggregation","during","sorocarp","development",".","Aggregation","involved","in","sorocarp","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","aggregate","over","time",",","from","its","formation","to","the","point","when","a","slug","is","formed",".","Aggregate","development","begins","in","response","to","starvation","and","continues","by","the","chemoattractant-mediated","movement","of","cells","toward","each","other",".","The","aggregate","is","a","multicellular","structure","that","gives","rise","to","the","slug","."),4108521). assertion_content_comment('tOboGo_RegulationOfAldosteroneBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","aldosterone","."),4056061). assertion_content_comment('tOboGo_RegulationOfAldosteroneMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","aldosterone","."),4056037). assertion_content_comment('tOboGo_RegulationOfAlkalinePhosphataseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","alkaline","phosphatase","activity",",","the","catalysis","of","the","reaction",":","an","orthophosphoric","monoester","+","H2O","=","an","alcohol","+","phosphate",",","with","an","alkaline","pH","optimum","."),4336489). assertion_content_comment('tOboGo_RegulationOfAlternativeNuclearMRNASplicingViaSpliceosome',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","alternative","splicing","of","nuclear","mRNAs","."),3974766). assertion_content_comment('tOboGo_RegulationOfAmineTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amines","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990674). assertion_content_comment('tOboGo_RegulationOfAminoAcidExport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","amino","acid","export",".","Amino","acid","export","is","the","directed","movement","of","amino","acids","out","of","a","cell","or","organelle","."),4147900). assertion_content_comment('tOboGo_RegulationOfAminoAcidImport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","amino","acid","import",".","Amino","acid","import","is","the","directed","movement","of","amino","acids","into","a","cell","or","organelle","."),4025896). assertion_content_comment('tOboGo_RegulationOfAminoAcidTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amino","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990677). assertion_content_comment('tOboGo_RegulationOfAminoAcidUptakeInvolvedInSynapticTransmission',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","amino","acid","neurotransmitters","into","a","neuron","or","glial","cell","."),4120344). assertion_content_comment('tOboGo_RegulationOfAmyloidPrecursorProteinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","amyloid","precursor","protein","(","APP",")",",","the","precursor","of","beta-amyloid","."),4093742). assertion_content_comment('tOboGo_RegulationOfAnagen',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","anagen",",","the","growth","phase","of","the","hair","cycle","."),4122495). assertion_content_comment('tOboGo_RegulationOfAnatomicalStructureMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","anatomical","structure","morphogenesis","."),3985470). assertion_content_comment('tOboGo_RegulationOfAnatomicalStructureSize',s("Any","process","that","modulates","the","size","of","an","anatomical","structure","."),3980873). assertion_content_comment('tOboGo_RegulationOfAndrogenReceptorSignalingPathway',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","androgen","receptor","signaling","pathway","."),4111011). assertion_content_comment('tOboGo_RegulationOfAngioblastCellMigrationInvolvedInSelectiveAngioblastSprouting',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","angioblast","cell","migration","involved","in","selective","angioblast","sprouting","."),4084476). assertion_content_comment('tOboGo_RegulationOfAngiogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","angiogenesis","."),4040534). assertion_content_comment('tOboGo_RegulationOfAngiotensinLevelsInBlood',s("The","process","that","modulates","the","level","of","angiotensin","in","the","blood","by","balancing","the","maturation","of","renin","substrate","to","mature","angiotensin","and","the","catabolism","of","mature","angiotensin","."),3991679). assertion_content_comment('tOboGo_RegulationOfAngiotensinMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","angiotensin","."),3991675). assertion_content_comment('tOboGo_RegulationOfAnionChannelActivityByBlueLight',s("Any","process","in","which","blue","light","modulates","the","frequency",",","rate","or","extent","of","anion","channel","activity","."),4332123). assertion_content_comment('tOboGo_RegulationOfAnionChannelActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","anion","channel","activity","."),4332074). assertion_content_comment('tOboGo_RegulationOfAnionTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","anions",",","atoms","or","small","molecules","with","a","net","negative","charge","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990645). assertion_content_comment('tOboGo_RegulationOfAnoikis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","anoikis","."),4141099). assertion_content_comment('tOboGo_RegulationOfAnthocyaninBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","anthocyanins","."),4060575). assertion_content_comment('tOboGo_RegulationOfAnthocyaninMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","involving","anthocyanins","."),4060571). assertion_content_comment('tOboGo_RegulationOfAntibacterialPeptideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","biosynthesis","."),4000819). assertion_content_comment('tOboGo_RegulationOfAntibacterialPeptideProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","production","."),3997414). assertion_content_comment('tOboGo_RegulationOfAntibacterialPeptideSecretion',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antibacterial","peptide","secretion","."),3997418). assertion_content_comment('tOboGo_RegulationOfAntifungalPeptideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","biosynthesis","."),4000920). assertion_content_comment('tOboGo_RegulationOfAntifungalPeptideProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","production","."),3997496). assertion_content_comment('tOboGo_RegulationOfAntifungalPeptideSecretion',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antifungal","peptide","secretion","."),3997673). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentationOfLipidAntigenViaMHCClassIb',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","lipid","antigen","via","MHC","class","Ib","."),3994914). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentationOfPeptideAntigen',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","."),3994981). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassIb',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","Ib","."),3995004). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassII',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","II","."),3996145). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentationOfPeptideAntigenViaMHCClassI',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","peptide","antigen","via","MHC","class","I","."),3995075). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentationOfPeptideOrPolysaccharideAntigenViaMHCClassII',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","antigen","(","peptide","or","polysaccharide",")","via","MHC","class","II","."),3994808). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentationOfPolysaccharideAntigenViaMHCClassII',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","polysaccharide","antigen","via","MHC","class","II","."),3994829). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","."),3994372). assertion_content_comment('tOboGo_RegulationOfAntigenProcessingAndPresentationViaMHCClassIb',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antigen","processing","and","presentation","of","antigen","via","MHC","class","Ib","."),3994896). assertion_content_comment('tOboGo_RegulationOfAntimicrobialHumoralResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","antimicrobial","humoral","response","."),3993353). assertion_content_comment('tOboGo_RegulationOfAntimicrobialPeptideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","biosynthesis","."),3997606). assertion_content_comment('tOboGo_RegulationOfAntimicrobialPeptideProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","production","."),3993356). assertion_content_comment('tOboGo_RegulationOfAntimicrobialPeptideSecretion',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antimicrobial","peptide","secretion","."),3997317). assertion_content_comment('tOboGo_RegulationOfAntipodalCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","antipodal","cell","differentiation","."),4091517). assertion_content_comment('tOboGo_RegulationOfAntisenseRNATranscription',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","synthesis","of","antisense","RNA",",","an","RNA","molecule","complementary","in","sequence","to","another","RNA","or","DNA","molecule",",","which",",","by","binding","the","latter",",","acts","to","inhibit","its","function","and/or","completion","of","synthesis",",","on","a","template","of","DNA","."),4115574). assertion_content_comment('tOboGo_RegulationOfAntralOvarianFollicleGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","antral","ovarian","follicle","growth","."),4088186). assertion_content_comment('tOboGo_RegulationOfAplanosporeFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","aplanospore","formation",",","a","process","in","which","a","nonmotile",",","asexual","spore","is","formed","within","a","cell","in","certain","algae","and","fungi","(","commonly","in","the","Phycomycetes",")",",","the","wall","of","aplanospore","is","distinct","from","that","of","the","parent","cell","."),4148237). assertion_content_comment('tOboGo_RegulationOfApoptosisBySphingolipidSignalingPathway',s("A","series","of","molecular","signals","mediated","by","a","sphingolipid","that","modulates","the","rate",",","frequency",",","or","extent","of","apoptosis","."),4194154). assertion_content_comment('tOboGo_RegulationOfApoptosisInBoneMarrow',s("Any","process","that","modulates","the","occurrence","or","rate","of","cell","death","by","apoptosis","in","the","bone","marrow","."),4082019). assertion_content_comment('tOboGo_RegulationOfApoptosisInvolvedInTissueHomeostasis',s("Any","process","that","modulates","the","occurrence","or","rate","of","cell","death","by","apoptosis","that","results","in","the","maintenance","of","the","steady-state","number","of","cells","within","a","tissue","."),4110862). assertion_content_comment('tOboGo_RegulationOfApoptosis',s("Any","process","that","modulates","the","occurrence","or","rate","of","cell","death","by","apoptosis","."),3983098). assertion_content_comment('tOboGo_RegulationOfApoptoticCellClearance',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","apoptotic","cell","clearance","."),4141758). assertion_content_comment('tOboGo_RegulationOfAppetite',s("Any","process","which","modulates","appetite",",","the","desire","or","physical","craving","for","food","."),4057139). assertion_content_comment('tOboGo_RegulationOfAppressoriumFormationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","appressorium","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146991). assertion_content_comment('tOboGo_RegulationOfAppressoriumInitiationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","appressorium","initiation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147400). assertion_content_comment('tOboGo_RegulationOfAppressoriumMaturationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","appressorium","maturation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147006). assertion_content_comment('tOboGo_RegulationOfArachidonicAcidSecretion',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","arachidonic","acid","secretion",",","the","controlled","release","of","arachidonic","acid","from","a","cell","or","group","of","cells","."),4151565). assertion_content_comment('tOboGo_RegulationOfArbusculeFormationForNutrientAcquisitionFromHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","arbuscule","formation","for","nutrient","acquisition","from","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4148886). assertion_content_comment('tOboGo_RegulationOfARFGTPaseActivity',s("Any","process","that","modulates","the","activity","of","the","GTPase","ARF","."),4056371). assertion_content_comment('tOboGo_RegulationOfARFProteinSignalTransduction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ARF","protein","signal","transduction","."),4056361). assertion_content_comment('tOboGo_RegulationOfArginineBiosyntheticProcessViaOrnithine',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","arginine","biosynthetic","process","via","ornithine","."),4139311). assertion_content_comment('tOboGo_RegulationOfArginineMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","arginine",",","2-amino-5-","(","carbamimidamido",")","pentanoic","acid","."),3979077). assertion_content_comment('tOboGo_RegulationOfAscosporeFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ascospore","formation",".","An","example","of","this","process","is","found","in","Saccharomyces","cerevisiae","."),4075377). assertion_content_comment('tOboGo_RegulationOfAscosporeWallChitinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","ascospore","wall","chitin","."),4075463). assertion_content_comment('tOboGo_RegulationOfAscosporeWallChitinCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ascospore","wall","chitin","."),4075675). assertion_content_comment('tOboGo_RegulationOfAscusDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ascus","development",",","a","process","that","leads","to","the","formation","of","basidium",",","a","sac-like","structure","produced","by","fungi","of","the","phylum","Ascomycota","(","sac","fungi",")","in","which","sexually","produced","spores","(","ascospores",")",",","usually","four","or","eight","in","number",",","are","formed","."),4147939). assertion_content_comment('tOboGo_RegulationOfAsexualSporulationResultingInFormationOfACellularSpore',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","of","a","cellular","spore","derived","from","the","products","of","mitosis","."),4096513). assertion_content_comment('tOboGo_RegulationOfAsexualSporulation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","spore","formation","from","the","products","of","mitosis","."),4075323). assertion_content_comment('tOboGo_RegulationOfAstrocyteChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","astrocyte","chemotaxis","."),4142119). assertion_content_comment('tOboGo_RegulationOfAstrocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","astrocyte","differentiation","."),4107229). assertion_content_comment('tOboGo_RegulationOfAsymmetricCellDivision',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","asymmetric","cell","division","."),4022490). assertion_content_comment('tOboGo_RegulationOfATP_ADPAntiporterActivity',s("Any","process","that","modulates","the","activity","of","an","ATP",":","ADP","antiporter","."),4178233). assertion_content_comment('tOboGo_RegulationOfATPaseActivity',s("Any","process","that","modulates","the","rate","of","ATP","hydrolysis","by","an","ATPase","."),4324981). assertion_content_comment('tOboGo_RegulationOfAtrialCardiomyocyteMembraneDepolarization',s("Any","process","that","modulates","the","establishment","or","extent","of","a","membrane","potential","in","the","depolarizing","direction","away","from","the","resting","potential","in","an","atrial","cardiomyocyte","."),4160340). assertion_content_comment('tOboGo_RegulationOfAtrialCardiomyocyteMembraneRepolarization',s("Any","process","that","modulates","the","establishment","or","extent","of","a","membrane","potential","in","the","polarizing","direction","towards","the","resting","potential","in","an","atrial","cardiomyocyte","."),4160327). assertion_content_comment('tOboGo_RegulationOfAtrichoblastFateSpecification',s("Any","process","that","modulates","atrichoblast","fate","specification","."),4032658). assertion_content_comment('tOboGo_RegulationOfAttachmentOfSpindleMicrotubulesToKinetochore',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","attachment","of","spindle","microtubules","to","the","kinetochore","."),4120724). assertion_content_comment('tOboGo_RegulationOfAuditoryReceptorCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","auditory","hair","cell","differentiation","."),4033472). assertion_content_comment('tOboGo_RegulationOfAuditoryReceptorCellFateSpecification',s("Any","process","that","mediates","the","specification","of","a","cell","into","an","auditory","hair","cell","."),4033476). assertion_content_comment('tOboGo_RegulationOfAutophagicVacuoleSize',s("Any","process","that","modulates","the","size","of","the","autophagic","vacuole","."),4034075). assertion_content_comment('tOboGo_RegulationOfAutophagy',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","autophagy",".","Autophagy","is","the","process","in","which","cells","digest","parts","of","their","own","cytoplasm","."),4030438). assertion_content_comment('tOboGo_RegulationOfAuxinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","auxins",",","plant","hormones","that","regulate","aspects","of","plant","growth","."),4028006). assertion_content_comment('tOboGo_RegulationOfAuxinMediatedSignalingPathway',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","auxin","mediated","signaling","pathway",".","Auxin","mediated","signaling","pathway","is","the","series","of","molecular","signals","generated","in","response","to","detection","of","auxin","."),4034766). assertion_content_comment('tOboGo_RegulationOfAuxinMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","auxins",",","plant","hormones","that","regulate","aspects","of","plant","growth","."),4028002). assertion_content_comment('tOboGo_RegulationOfAuxinPolarTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","auxin","polar","transport","."),4139333). assertion_content_comment('tOboGo_RegulationOfAxialMesodermalCellFateDetermination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","axial","mesoderm","cell","fate","determination","."),4102903). assertion_content_comment('tOboGo_RegulationOfAxialMesodermalCellFateSpecification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","axial","mesoderm","cell","fate","specification","."),4102840). assertion_content_comment('tOboGo_RegulationOfAxonDiameter',s("Any","process","that","modulates","the","rate",",","direction","or","extent","of","axon","growth","such","that","the","correct","diameter","is","attained","and","maintained","."),4318796). assertion_content_comment('tOboGo_RegulationOfAxonExtensionInvolvedInAxonGuidance',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","axon","extension","involved","in","axon","guidance","."),4105394). assertion_content_comment('tOboGo_RegulationOfAxonExtensionInvolvedInRegeneration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","axon","extension","involved","in","regeneration","."),4107055). assertion_content_comment('tOboGo_RegulationOfAxonExtension',s("Any","process","that","modulates","the","rate",",","direction","or","extent","of","axon","extension","."),4046618). assertion_content_comment('tOboGo_RegulationOfAxonogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","axonogenesis",",","the","generation","of","an","axon",",","the","long","process","of","a","neuron","."),4046615). assertion_content_comment('tOboGo_RegulationOfAxonRegeneration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","axon","regeneration","."),4106744). assertion_content_comment('tOboGo_RegulationOfBackwardLocomotion',s("Any","process","that","modulates","the","speed",",","mechanical","force",",","or","rhythm","of","the","posterior","movement","of","an","organism","."),4094299). assertion_content_comment('tOboGo_RegulationOfBarrierSeptumFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","barrier","septum","formation",".","Barrier","septum","formation","is","the","assembly","and","arrangement","of","a","septum","that","spans","the","plasma","membrane","interface","between","progeny","cells","following","cytokinesis","."),4035417). assertion_content_comment('tOboGo_RegulationOfBasalLaminaDisassemblyInvolvedInSemicircularCanalFusionByCellCommunication',s("Any","process","that","mediates","interactions","between","a","cell","and","its","surroundings","that","modulates","of","the","rate",",","frequency","or","extent","of","basal","lamina","disassembly","involved","in","semicircular","canal","fusion","."),4114038). assertion_content_comment('tOboGo_RegulationOfBasidiosporeFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","basidiospore","formation",",","a","process","in","which","a","sexually","produced","fungal","spore","is","formed","on","a","basidium","in","the","fungi","Basidiomycetes","."),4148103). assertion_content_comment('tOboGo_RegulationOfBasidiumDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","basidium","development",",","a","process","that","leads","to","the","formation","of","a","basidium",",","a","small",",","specialized","club-shaped","structure","typically","bearing","four","basidiospores","at","the","tips","of","minute","projections",".","The","basidium","is","unique","to","Basidiomycetes","and","distinguishes","them","from","other","kinds","of","fungi","."),4148017). assertion_content_comment('tOboGo_RegulationOfBasophilDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","basophil","differentiation","."),4087564). assertion_content_comment('tOboGo_RegulationOfBCellActivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","B","cell","activation","."),3989111). assertion_content_comment('tOboGo_RegulationOfBCellAnergy',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B","cell","anergy","."),3998369). assertion_content_comment('tOboGo_RegulationOfBCellAntigenProcessingAndPresentation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B","cell","antigen","processing","and","presentation","."),3994440). assertion_content_comment('tOboGo_RegulationOfBCellApoptosis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B","cell","apoptosis","."),3999362). assertion_content_comment('tOboGo_RegulationOfBCellChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","B","cell","chemotaxis","."),4144954). assertion_content_comment('tOboGo_RegulationOfBCellCytokineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B","cell","cytokine","production","."),3998493). assertion_content_comment('tOboGo_RegulationOfBCellDeletion',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B","cell","deletion","."),3999365). assertion_content_comment('tOboGo_RegulationOfBCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","B","cell","differentiation","."),3989117). assertion_content_comment('tOboGo_RegulationOfBCellMediatedImmunity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B","cell","mediated","immunity","."),3983329). assertion_content_comment('tOboGo_RegulationOfBCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","B","cell","proliferation","."),4061978). assertion_content_comment('tOboGo_RegulationOfBCellReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signaling","pathways","initiated","by","the","cross-linking","of","an","antigen","receptor","on","a","B","cell","."),4100777). assertion_content_comment('tOboGo_RegulationOfBCellToleranceInduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B","cell","tolerance","induction","."),3995171). assertion_content_comment('tOboGo_RegulationOfBehavior',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","behavior",",","the","specific","actions","or","reactions","of","an","organism","in","response","to","external","or","internal","stimuli","."),3997977). assertion_content_comment('tOboGo_RegulationOfBeta2IntegrinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta","2","integrins","."),4086544). assertion_content_comment('tOboGo_RegulationOfBicoidMRNALocalization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","process","in","which","bicoid","mRNA","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4020684). assertion_content_comment('tOboGo_RegulationOfBileAcidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","bile","acids","."),4132181). assertion_content_comment('tOboGo_RegulationOfBindingOfSpermToZonaPellucida',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","binding","of","sperm","to","the","zona","pellucida","."),4142890). assertion_content_comment('tOboGo_RegulationOfBinding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","binding",",","the","selective","interaction","of","a","molecule","with","one","or","more","specific","sites","on","another","molecule","."),4154931). assertion_content_comment('tOboGo_RegulationOfBiologicalQuality',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","biological","quality",".","A","biological","quality","is","a","measurable","attribute","of","an","organism","or","part","of","an","organism",",","such","as","size",",","mass",",","shape",",","color",",","etc","."),3980869). assertion_content_comment('tOboGo_RegulationOfBiomineralTissueDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","biomineral","tissue","development",",","the","formation","of","hard","tissues","that","consist","mainly","of","inorganic","compounds","."),4046716). assertion_content_comment('tOboGo_RegulationOfBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","substances","."),3970926). assertion_content_comment('tOboGo_RegulationOfBipolarCellGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","bipolar","cell","growth",",","polarized","growth","from","both","ends","of","a","cell","."),4118762). assertion_content_comment('tOboGo_RegulationOfBloodCoagulationCommonPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","blood","coagulation",",","common","pathway","."),4140310). assertion_content_comment('tOboGo_RegulationOfBloodCoagulationExtrinsicPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","blood","coagulation",",","extrinsic","pathway","."),4140258). assertion_content_comment('tOboGo_RegulationOfBloodCoagulationIntrinsicPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","blood","coagulation",",","intrinsic","pathway","."),4140203). assertion_content_comment('tOboGo_RegulationOfBloodCoagulation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","blood","coagulation","."),3996563). assertion_content_comment('tOboGo_RegulationOfBloodMicroparticleFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","blood","microparticle","formation","."),4143144). assertion_content_comment('tOboGo_RegulationOfBloodPressure',s("Any","process","that","modulates","the","force","with","which","blood","travels","through","the","circulatory","system",".","The","process","is","controlled","by","a","balance","of","processes","that","increase","pressure","and","decrease","pressure","."),3987262). assertion_content_comment('tOboGo_RegulationOfBloodVesselEndothelialCellMigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","migration","of","the","endothelial","cells","of","blood","vessels","."),4094400). assertion_content_comment('tOboGo_RegulationOfBloodVesselRemodeling',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","blood","vessel","remodeling",",","the","reorganization","or","renovation","of","existing","blood","vessels","."),4114812). assertion_content_comment('tOboGo_RegulationOfBloodVesselSize',s("Any","process","that","modulates","the","size","of","blood","vessels","."),3987424). assertion_content_comment('tOboGo_RegulationOfBloodVolumeByRenalAldosterone',s("The","process","in","which","the","hormone","aldosterone","decreases","the","rate","of","diuresis","and","natriuresis","resulting","in","increased","blood","volume","."),4374228). assertion_content_comment('tOboGo_RegulationOfBMKCascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","BMK","cascade","."),4136275). assertion_content_comment('tOboGo_RegulationOfBMPSignalingPathwayInvolvedInHeartJogging',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","BMP","signaling","pathway","involved","in","heart","jogging","."),4140844). assertion_content_comment('tOboGo_RegulationOfBMPSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","activity","of","any","BMP","receptor","signaling","pathway","."),4046759). assertion_content_comment('tOboGo_RegulationOfBodyFluidLevels',s("Any","process","that","modulates","the","levels","of","body","fluids","."),3987554). assertion_content_comment('tOboGo_RegulationOfBorderFollicleCellDelamination',s("Any","process","that","regulates","the","frequency",",","rate","or","extent","of","border","cell","delamination","."),4052110). assertion_content_comment('tOboGo_RegulationOfBranchElongationInvolvedInUretericBudBranching',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","branch","elongation","involved","in","ureteric","bud","branching",",","the","growth","of","a","branch","of","the","ureteric","bud","along","its","axis","."),4123896). assertion_content_comment('tOboGo_RegulationOfBranchingInvolvedInLungMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","process","in","which","a","highly","ordered","sequence","of","patterning","events","generates","the","branched","structures","of","the","lung",",","consisting","of","reiterated","combinations","of","bud","outgrowth",",","elongation",",","and","dichotomous","subdivision","of","terminal","units","."),4113502). assertion_content_comment('tOboGo_RegulationOfBranchingInvolvedInMammaryGlandDuctMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","branching","involved","in","mammary","gland","duct","morphogenesis","."),4111050). assertion_content_comment('tOboGo_RegulationOfBranchingInvolvedInProstateGlandMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","prostate","gland","branching",",","the","process","in","which","the","branching","structure","of","the","prostate","gland","is","generated","and","organized",".","A","branch","is","a","division","or","offshoot","from","a","main","stem","."),4112317). assertion_content_comment('tOboGo_RegulationOfBranchingInvolvedInSalivaryGlandMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","branching","morphogenesis","in","the","salivary","gland","epithelium","."),4112338). assertion_content_comment('tOboGo_RegulationOfBranchingInvolvedInUretericBudMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","branching","involved","in","ureteric","bud","morphogenesis",",","the","process","in","which","the","branching","structure","of","the","ureteric","bud","is","generated","and","organized",".","The","ureteric","bud","is","an","epithelial","tube","that","grows","out","from","the","metanephric","duct",".","The","bud","elongates","and","branches","to","give","rise","to","the","ureter","and","kidney","collecting","tubules","."),4123893). assertion_content_comment('tOboGo_RegulationOfBranchingMorphogenesisOfANerve',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","branching","morphogenesis","of","a","nerve","."),4141526). assertion_content_comment('tOboGo_RegulationOfBranchiomericSkeletalMuscleDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","branchiomeric","skeletal","muscle","development",".","Branchiomeric","skeletal","muscle","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","branchiomeric","skeletal","muscle","over","time",",","from","its","formation","to","the","mature","structure","."),4039720). assertion_content_comment('tOboGo_RegulationOfBrassinosteroidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","brassinosteroids","."),4029268). assertion_content_comment('tOboGo_RegulationOfBroodSize',s("Any","process","that","modulates","the","extent","of","brood","size",".","Brood","size","is","the","number","of","progeny","that","survive","embryogenesis","and","are","cared","for","at","one","time","."),4160192). assertion_content_comment('tOboGo_RegulationOfBrownFatCellDifferentiation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","brown","fat","cell","differentiation",".","Brown","fat","cell","differentiation","is","the","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","brown","adipocyte",",","an","animal","connective","tissue","cell","involved","in","adaptive","thermogenesis",".","Brown","adipocytes","contain","multiple","small","droplets","of","triglycerides","and","a","high","number","of","mitochondria","."),4150657). assertion_content_comment('tOboGo_RegulationOfBrownFatCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","brown","fat","cell","proliferation","."),4136741). assertion_content_comment('tOboGo_RegulationOfBuddingCellApicalBudGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","growth","at","the","tip","of","a","bud",",","in","a","cell","that","reproduces","by","budding","."),4027357). assertion_content_comment('tOboGo_RegulationOfBuoyancy',s("Any","process","that","modulates","an","organism","'","s","tendency","or","ability","to","rise","or","float","in","a","fluid","medium","such","as","water","or","air",",","often","through","the","use","of","stored","gases","."),4319505). assertion_content_comment('tOboGo_RegulationOfCalciumInER',s("OBSOLETE",".","Any","process","that","modulates","the","concentration","of","calcium","in","the","endoplasmic","reticulum","."),4228972). assertion_content_comment('tOboGo_RegulationOfCalciumIonImport',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","directed","movement","of","calcium","ions","into","a","cell","or","organelle","."),4151712). assertion_content_comment('tOboGo_RegulationOfCalciumIonTransportIntoCytosol',s("Any","process","that","modulates","the","rate","of","the","directed","movement","of","calcium","ions","into","the","cytosol","of","a","cell",".","The","cytosol","is","that","part","of","the","cytoplasm","that","does","not","contain","membranous","or","particulate","subcellular","components","."),4029752). assertion_content_comment('tOboGo_RegulationOfCalciumIonTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","calcium","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4029747). assertion_content_comment('tOboGo_RegulationOfCAMPBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4027729). assertion_content_comment('tOboGo_RegulationOfCAMPCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4050133). assertion_content_comment('tOboGo_RegulationOfCAMPMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4027661). assertion_content_comment('tOboGo_RegulationOfCanonicalWntReceptorSignalingPathwayInvolvedInControllingTypeBPancreaticCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","canonical","Wnt","receptor","signaling","pathway","modulating","the","rate","or","frequency","of","pancreatic","B","cell","proliferation","."),4138672). assertion_content_comment('tOboGo_RegulationOfCanonicalWntReceptorSignalingPathwayInvolvedInNeuralCrestCellDifferentiation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","Wnt","receptor","signaling","pathway","through","beta-catenin","involved","in","neural","crest","cell","differentiation",".","The","Wnt","receptor","signaling","pathway","is","the","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","."),4127055). assertion_content_comment('tOboGo_RegulationOfCanonicalWntReceptorSignalingPathwayInvolvedInNeuralPlateAnteriorPosteriorPatternFormation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","Wnt","receptor","signaling","through","beta-catenin","that","results","in","the","formation","of","the","neural","plate","anterior/posterior","pattern","."),4111327). assertion_content_comment('tOboGo_RegulationOfCanonicalWntReceptorSignalingPathway',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","Wnt","receptor","signaling","pathway","through","beta-catenin",",","the","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","."),4111322). assertion_content_comment('tOboGo_RegulationOfCarbohydrateBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","carbohydrates","."),4009146). assertion_content_comment('tOboGo_RegulationOfCarbohydrateCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carbohydrates","."),4008929). assertion_content_comment('tOboGo_RegulationOfCarbohydrateMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","carbohydrates","."),4008910). assertion_content_comment('tOboGo_RegulationOfCarbohydratePhosphataseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","carbohydrate","phosphatase","activity",",","the","catalysis","of","the","hydrolysis","of","phosphate","from","a","carbohydrate","phosphate","."),4160756). assertion_content_comment('tOboGo_RegulationOfCarbohydrateUtilization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","carbohydrate","utilization","."),4094667). assertion_content_comment('tOboGo_RegulationOfCarbonUtilization',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","carbon","utilization","."),4094650). assertion_content_comment('tOboGo_RegulationOfCardiacCellFateSpecification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardiac","cell","fate","specification","."),4003425). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleAdaptation',s("Any","process","that","modulates","the","rate",",","extent","or","frequency","of","the","process","in","which","cardiac","muscle","adapts",",","with","consequent","modifications","to","structural","and/or","functional","phenotypes",",","in","response","to","a","stimulus",".","Stimuli","include","contractile","activity",",","loading","conditions",",","substrate","supply",",","and","environmental","factors","."),4028293). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleCellApoptosis',s("Any","process","that","modulates","the","rate","or","extent","of","cardiac","cell","apoptosis",".","Cardiac","cell","apoptosis","is","a","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","cardiac","muscle","cell","and","result","in","its","death","."),4026282). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardiac","muscle","cell","proliferation","."),4109201). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleContractionByCalciumIonSignaling',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardiac","muscle","contraction","by","changing","the","calcium","ion","signals","that","trigger","contraction","."),4335987). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleContractionByRegulationOfTheReleaseOfSequesteredCalciumIon',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardiac","muscle","contraction","via","the","regulation","of","the","release","of","sequestered","calcium","ion","by","sarcoplasmic","reticulum","into","cytosol",".","The","sarcoplasmic","reticulum","is","the","endoplasmic","reticulum","of","striated","muscle",",","specialised","for","the","sequestration","of","calcium","ions","that","are","released","upon","receipt","of","a","signal","relayed","by","the","T","tubules","from","the","neuromuscular","junction","."),4335998). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleContraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardiac","muscle","contraction","."),4109464). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleFiberDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardiac","muscle","fiber","development","."),4107600). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleHypertrophy',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","enlargement","or","overgrowth","of","all","or","part","of","the","heart","due","to","an","increase","in","size","(","not","length",")","of","individual","cardiac","muscle","fibers",",","without","cell","division","."),4028314). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleTissueDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardiac","muscle","tissue","development","."),4107570). assertion_content_comment('tOboGo_RegulationOfCardiacMuscleTissueGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardiac","muscle","growth","."),4107777). assertion_content_comment('tOboGo_RegulationOfCardioblastCellFateSpecification',s("Any","process","that","mediates","the","specification","of","a","cell","into","a","cardioblast",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4003448). assertion_content_comment('tOboGo_RegulationOfCardioblastDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardioblast","differentiation",",","the","process","in","which","a","relatively","unspecialized","mesodermal","cell","acquires","the","specialized","structural","and/or","functional","features","of","a","cardioblast",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4003373). assertion_content_comment('tOboGo_RegulationOfCardioblastProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardioblast","proliferation",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4001024). assertion_content_comment('tOboGo_RegulationOfCaspaseActivity',s("Any","process","that","modulates","the","activity","of","a","caspase",",","any","of","a","group","of","cysteine","proteases","involved","in","apoptosis","."),4011561). assertion_content_comment('tOboGo_RegulationOfCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","substances","."),3979590). assertion_content_comment('tOboGo_RegulationOfCatagen',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","catagen",",","the","regression","phase","of","the","hair","cycle","."),4122316). assertion_content_comment('tOboGo_RegulationOfCatalyticActivity',s("Any","process","that","modulates","the","activity","of","an","enzyme","."),3972501). assertion_content_comment('tOboGo_RegulationOfCatecholamineMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","catecholamines","."),4080429). assertion_content_comment('tOboGo_RegulationOfCatecholamineSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","catecholamines","."),4026675). assertion_content_comment('tOboGo_RegulationOfCatecholamineUptakeInvolvedInSynapticTransmission',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","catecholamine","neurotransmitters","into","a","neuron","or","glial","cell","."),4120374). assertion_content_comment('tOboGo_RegulationOfCateninImportIntoNucleus',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","directed","movement","of","a","catenin","protein","from","the","cytoplasm","into","the","nucleus","."),4083135). assertion_content_comment('tOboGo_RegulationOfCD24BiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CD24","biosynthetic","process","."),4144340). assertion_content_comment('tOboGo_RegulationOfCD40SignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signaling","via","the","CD40","signaling","pathway","."),4143390). assertion_content_comment('tOboGo_RegulationOfCD4BiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","CD4","."),4086240). assertion_content_comment('tOboGo_RegulationOfCdc42GTPaseActivity',s("Any","process","that","modulates","the","activity","of","the","GTPase","Cdc42","."),4094338). assertion_content_comment('tOboGo_RegulationOfCdc42ProteinSignalTransduction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","Cdc42","protein","signal","transduction","."),4055772). assertion_content_comment('tOboGo_RegulationOfCellActivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","activation",",","the","change","in","the","morphology","or","behavior","of","a","cell","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand","."),3989087). assertion_content_comment('tOboGo_RegulationOfCellAdhesionInvolvedInGrowthPlateCartilageMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","attachment","of","a","cell","to","another","cell","or","to","the","extracellular","matrix","and","contributes","to","the","shaping","of","the","growth","plate","cartilage","of","an","endochondral","bone","."),4004291). assertion_content_comment('tOboGo_RegulationOfCellAdhesionInvolvedInHeartMorphogenesis',s("Any","process","that","modulates","the","extent","of","cell","adhesion","contributing","to","the","shaping","of","the","heart","."),4135022). assertion_content_comment('tOboGo_RegulationOfCellAdhesionInvolvedInIntussusceptiveAngiogenesis',s("The","process","that","modulates","the","frequency",",","rate","or","extent","of","attachment","of","a","blood","vessel","endothelial","cell","to","another","cell","or","to","the","extracellular","matrix","involved","in","intussusceptive","angiogenesis","."),3990900). assertion_content_comment('tOboGo_RegulationOfCellAdhesionMediatedByIntegrin',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","cell","adhesion","mediated","by","integrin","."),4063664). assertion_content_comment('tOboGo_RegulationOfCellAdhesionMoleculeProduction',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","cell","adhesion","molecule","production",".","Cell","adhesion","molecule","production","is","the","appearance","of","a","cell","adhesion","molecule","as","a","result","of","its","biosynthesis","or","a","decrease","in","its","catabolism","."),4115186). assertion_content_comment('tOboGo_RegulationOfCellAdhesion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","attachment","of","a","cell","to","another","cell","or","to","the","extracellular","matrix","."),3987966). assertion_content_comment('tOboGo_RegulationOfCellAging',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","cell","aging",".","Cell","aging","is","the","progression","of","the","cell","from","its","inception","to","the","end","of","its","lifespan","."),4151007). assertion_content_comment('tOboGo_RegulationOfCellBudding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","and","growth","of","cell","buds","."),4011830). assertion_content_comment('tOboGo_RegulationOfCellCommunicationByChemicalCoupling',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","communication","via","chemical","coupling",".","Cell","communication","by","chemical","coupling","is","the","process","that","mediates","signaling","interactions","between","one","cell","and","another","cell","by","the","transfer","of","small",",","water-soluble","molecules","or","metabolites","between","their","adjacent","cytoplasms","via","intercellular","protein","channels","."),4026137). assertion_content_comment('tOboGo_RegulationOfCellCommunicationByElectricalCoupling',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","communication","via","electrical","coupling",".","Cell","communication","via","electrical","coupling","is","the","process","that","mediates","signaling","interactions","between","one","cell","and","another","cell","by","transfer","of","current","between","their","adjacent","cytoplasms","via","intercellular","protein","channels","."),4026108). assertion_content_comment('tOboGo_RegulationOfCellCommunicationInvolvedInGrowthPlateCartilageMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","communication","that","contributes","to","the","shaping","of","the","growth","plate","cartilage","."),4004314). assertion_content_comment('tOboGo_RegulationOfCellCommunication',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","communication",".","Cell","communication","is","the","process","that","mediates","interactions","between","a","cell","and","its","surroundings",".","Encompasses","interactions","such","as","signaling","or","attachment","between","one","cell","and","another","cell",",","between","a","cell","and","an","extracellular","matrix",",","or","between","a","cell","and","any","other","aspect","of","its","environment","."),3987771). assertion_content_comment('tOboGo_RegulationOfCellCycleArrestInResponseToNitrogenStarvation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","cycle","arrest","in","response","to","nitrogen","starvation","."),4030405). assertion_content_comment('tOboGo_RegulationOfCellCycleArrest',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","cell","cycle","arrest",",","the","process","in","which","the","cell","cycle","is","halted","during","one","of","the","normal","phases","."),3970745). assertion_content_comment('tOboGo_RegulationOfCellCycleCytokinesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","division","of","the","cytoplasm","of","a","cell",",","and","its","separation","into","two","daughter","cells",",","that","occurs","in","the","context","of","cell","cycle","progression","."),4058122). assertion_content_comment('tOboGo_RegulationOfCellCycleProcess',s("Any","process","that","modulates","a","cellular","process","that","is","involved","in","the","progression","of","biochemical","and","morphological","phases","and","events","that","occur","in","a","cell","during","successive","cell","replication","or","nuclear","replication","events","."),3970742). assertion_content_comment('tOboGo_RegulationOfCellCycle',s("Any","process","that","modulates","the","rate","or","extent","of","progression","through","the","cell","cycle","."),3970695). assertion_content_comment('tOboGo_RegulationOfCellDeath',s("Any","process","that","modulates","the","rate","or","frequency","of","cell","death",".","Cell","death","is","the","specific","activation","or","halting","of","processes","within","a","cell","so","that","its","vital","functions","markedly","cease",",","rather","than","simply","deteriorating","gradually","over","time",",","which","culminates","in","cell","death","."),3983050). assertion_content_comment('tOboGo_RegulationOfCellDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","progression","of","the","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","specific","fate","."),3990321). assertion_content_comment('tOboGo_RegulationOfCellDiameter',s("Any","process","that","modulates","the","diameter","of","a","cell",",","the","length","of","a","line","segment","that","crosses","through","the","center","of","a","circular","section","through","a","cell","."),4160583). assertion_content_comment('tOboGo_RegulationOfCellDifferentiationInvolvedInEmbryonicPlacentaDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","cell","differentiation","that","contributes","to","the","progression","of","the","placenta","over","time",",","from","its","initial","condition","to","its","mature","state","."),4111162). assertion_content_comment('tOboGo_RegulationOfCellDifferentiationInvolvedInTissueHomeostasis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","differentiation","that","contributes","to","the","maintenance","of","a","steady","state","of","a","cell","type","within","a","tissue","."),4110881). assertion_content_comment('tOboGo_RegulationOfCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","differentiation",",","the","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and","functional","features","."),3989061). assertion_content_comment('tOboGo_RegulationOfCellDivision',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","physical","partitioning","and","separation","of","a","cell","into","daughter","cells","."),4004425). assertion_content_comment('tOboGo_RegulationOfCellFateCommitment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","fate","commitment",".","Cell","fate","commitment","is","the","commitment","of","cells","to","specific","cell","fates","and","their","capacity","to","differentiate","into","particular","kinds","of","cells",".","Positional","information","is","established","through","protein","signals","that","emanate","from","a","localized","source","within","a","cell","(","the","initial","one-cell","zygote",")","or","within","a","developmental","field","."),4003398). assertion_content_comment('tOboGo_RegulationOfCellFateSpecification',s("Any","process","that","mediates","the","adoption","of","a","specific","fate","by","a","cell","."),4003401). assertion_content_comment('tOboGo_RegulationOfCellGrowthByDetectionOfNuclear_CytoplasmicRatio',s("Any","process","in","which","the","size","of","the","nucleus","with","respect","to","the","cytoplasm","modulates","the","frequency",",","rate","or","extent","of","cell","growth",",","the","irreversible","increase","in","size","of","a","cell","over","time","."),4361369). assertion_content_comment('tOboGo_RegulationOfCellGrowthByExtracellularStimulus',s("Any","process","in","which","external","signals","modulate","the","frequency",",","rate","or","extent","of","cell","growth",",","the","irreversible","increase","in","size","of","a","cell","over","time","."),3980892). assertion_content_comment('tOboGo_RegulationOfCellGrowthInvolvedInCardiacMuscleCellDevelopment',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","growth","of","a","cardiac","muscle","cell",",","where","growth","contributes","to","the","progression","of","the","cell","over","time","from","its","initial","formation","to","its","mature","state","."),4113398). assertion_content_comment('tOboGo_RegulationOfCellGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","growth","."),3980889). assertion_content_comment('tOboGo_RegulationOfCellKilling',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","killing",",","the","process","in","which","a","cell","brings","about","the","death","of","another","cell",",","either","in","the","same","or","a","different","organism","."),3983360). assertion_content_comment('tOboGo_RegulationOfCellMigrationInvolvedInSproutingAngiogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","migration","involved","in","sprouting","angiogenesis",".","Cell","migration","involved","in","sprouting","angiogenesis","is","the","orderly","movement","of","endothelial","cells","into","the","extracellular","matrix","in","order","to","form","new","blood","vessels","contributing","to","the","process","of","sprouting","angiogenesis","."),4149923). assertion_content_comment('tOboGo_RegulationOfCellMigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","migration","."),3997819). assertion_content_comment('tOboGo_RegulationOfCellMorphogenesisInvolvedInDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","morphogenesis","contributing","to","cell","differentiation",".","Cell","morphogenesis","involved","in","differentiation","is","the","change","in","form","(","cell","shape","and","size",")","that","occurs","when","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","cells",",","tissues",",","or","organs","of","the","mature","organism","or","some","other","relatively","stable","phase","of","the","organism","'","s","life","history","."),4006174). assertion_content_comment('tOboGo_RegulationOfCellMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","morphogenesis",".","Cell","morphogenesis","is","the","developmental","process","in","which","the","shape","of","a","cell","is","generated","and","organized","."),4006167). assertion_content_comment('tOboGo_RegulationOfCellMotilityInvolvedInSomitogenicAxisElongation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","controlled","self-propelled","movement","of","a","cell","that","contributes","to","somitogenic","axis","elongation","."),4152025). assertion_content_comment('tOboGo_RegulationOfCellMotility',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","motility","."),3997813). assertion_content_comment('tOboGo_RegulationOfCellProjectionAssembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","cell","projection","assembly","."),4028494). assertion_content_comment('tOboGo_RegulationOfCellProjectionOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cell","projections","."),4028488). assertion_content_comment('tOboGo_RegulationOfCellProjectionSize',s("A","process","that","modulates","the","size","of","a","cell","projection","."),4318793). assertion_content_comment('tOboGo_RegulationOfCellProliferationInBoneMarrow',s("A","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","proliferation","in","the","bone","marrow","."),4082081). assertion_content_comment('tOboGo_RegulationOfCellProliferationInDorsalSpinalCord',s("The","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","proliferation","in","the","dorsal","spinal","cord","."),4048959). assertion_content_comment('tOboGo_RegulationOfCellProliferationInvolvedInCompoundEyeMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","compound","eye","morphogenesis","."),4145584). assertion_content_comment('tOboGo_RegulationOfCellProliferationInvolvedInEmbryonicPlacentaDevelopment',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","cell","proliferation","involved","in","embryonic","placenta","development","."),4112611). assertion_content_comment('tOboGo_RegulationOfCellProliferationInvolvedInHeartMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","heart","morphogenesis","."),4002959). assertion_content_comment('tOboGo_RegulationOfCellProliferationInvolvedInHeartValveMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","cell","proliferation","that","contributes","to","the","shaping","of","a","heart","valve","."),4002962). assertion_content_comment('tOboGo_RegulationOfCellProliferationInvolvedInKidneyMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","proliferation","that","contributes","to","the","shaping","of","the","kidney","."),4155865). assertion_content_comment('tOboGo_RegulationOfCellProliferationInvolvedInMesonephrosDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","proliferation","involved","in","mesonephros","development","."),4138189). assertion_content_comment('tOboGo_RegulationOfCellProliferationInvolvedInTissueHomeostasis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell","proliferation","resulting","in","the","maintenance","of","a","steady-state","number","of","cells","within","a","tissue","."),4110871). assertion_content_comment('tOboGo_RegulationOfCellShapeDuringVegetativeGrowthPhase',s("Any","process","that","modulates","the","surface","configuration","of","a","cell","during","the","vegetative","growth","phase",".","The","vegetative","growth","phase","is","the","growth","phase","during","which","single","celled","organisms","reproduce","by","budding","or","other","asexual","methods","."),4363649). assertion_content_comment('tOboGo_RegulationOfCellShape',s("Any","process","that","modulates","the","surface","configuration","of","a","cell","."),4019772). assertion_content_comment('tOboGo_RegulationOfCellSize',s("Any","process","that","modulates","the","size","of","a","cell","."),3980877). assertion_content_comment('tOboGo_RegulationOfCellularAmideCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","amides","."),4066752). assertion_content_comment('tOboGo_RegulationOfCellularAmideMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amides","."),4066734). assertion_content_comment('tOboGo_RegulationOfCellularAmineCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","leading","to","the","breakdown","of","amines","."),4066886). assertion_content_comment('tOboGo_RegulationOfCellularAmineMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","by","which","individual","cells","transform","amines","."),3979064). assertion_content_comment('tOboGo_RegulationOfCellularAminoAcidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cellular","amino","acid","biosynthetic","process","."),4139303). assertion_content_comment('tOboGo_RegulationOfCellularAminoAcidMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amino","acids","."),3979069). assertion_content_comment('tOboGo_RegulationOfCellularBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","substances",",","carried","out","by","individual","cells","."),3970979). assertion_content_comment('tOboGo_RegulationOfCellularCarbohydrateCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carbohydrates",",","carried","out","by","individual","cells","."),4008933). assertion_content_comment('tOboGo_RegulationOfCellularCarbohydrateMetabolicProcess',s("Any","process","that","modulates","the","rate",",","extent","or","frequency","of","the","chemical","reactions","and","pathways","involving","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y",",","as","carried","out","by","individual","cells","."),4008915). assertion_content_comment('tOboGo_RegulationOfCellularCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","substances",",","carried","out","by","individual","cells","."),3979597). assertion_content_comment('tOboGo_RegulationOfCellularComponentBiogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cellular","component","biogenesis",",","a","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","cellular","component","."),3988823). assertion_content_comment('tOboGo_RegulationOfCellularComponentMovement',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","movement","of","a","cellular","component","."),3997808). assertion_content_comment('tOboGo_RegulationOfCellularComponentOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cell","structures",",","including","the","plasma","membrane","and","any","external","encapsulating","structures","such","as","the","cell","wall","and","cell","envelope","."),3975620). assertion_content_comment('tOboGo_RegulationOfCellularComponentSize',s("A","process","that","modulates","the","size","of","a","cellular","component","."),3980875). assertion_content_comment('tOboGo_RegulationOfCellularDefenseResponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cellular","defense","response","."),4031484). assertion_content_comment('tOboGo_RegulationOfCellularExtravasation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","cellular","extravasation","."),3998089). assertion_content_comment('tOboGo_RegulationOfCellularKetoneMetabolicProcessByNegativeRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","cellular","ketone","metabolic","process","by","stopping",",","preventing",",","or","reducing","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4159209). assertion_content_comment('tOboGo_RegulationOfCellularKetoneMetabolicProcessByPositiveRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","cellular","ketone","metabolic","process","by","activating","or","increasing","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4159198). assertion_content_comment('tOboGo_RegulationOfCellularKetoneMetabolicProcessByRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","cellular","ketone","metabolic","process","by","modulating","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4159009). assertion_content_comment('tOboGo_RegulationOfCellularKetoneMetabolicProcess',s("Any","process","that","modulates","the","chemical","reactions","and","pathways","involving","any","of","a","class","of","organic","compounds","that","contain","the","carbonyl","group",",","CO",",","and","in","which","the","carbonyl","group","is","bonded","only","to","carbon","atoms",".","The","general","formula","for","a","ketone","is","RCOR",",","where","R","and","R","are","alkyl","or","aryl","groups","."),3979051). assertion_content_comment('tOboGo_RegulationOfCellularLocalization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","in","which","a","cell",",","a","substance",",","or","a","cellular","entity","is","transported","to",",","or","maintained","in","a","specific","location","within","or","in","the","membrane","of","a","cell","."),3988178). assertion_content_comment('tOboGo_RegulationOfCellularMacromoleculeBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cellular","macromolecule","biosynthetic","process","."),3971003). assertion_content_comment('tOboGo_RegulationOfCellularMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","by","which","individual","cells","transform","chemical","substances","."),3969102). assertion_content_comment('tOboGo_RegulationOfCellularOrganofluorineMetabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","involving","organofluorine","compounds",",","as","carried","out","by","individual","cells","."),4151072). assertion_content_comment('tOboGo_RegulationOfCellularOrganohalogenMetabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","involving","organohalogen","compounds",",","as","carried","out","by","individual","cells","."),4151053). assertion_content_comment('tOboGo_RegulationOfCellularPHReduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","process","that","reduces","the","internal","pH","of","a","cell","."),4070035). assertion_content_comment('tOboGo_RegulationOfCellularPH',s("Any","process","involved","in","the","maintenance","of","an","internal","equilibrium","of","hydrogen","ions","(","protons",")","within","a","cell","or","between","a","cell","and","its","external","environment","."),4070001). assertion_content_comment('tOboGo_RegulationOfCellularProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","cellular","process",",","any","of","those","that","are","carried","out","at","the","cellular","level",",","but","are","not","necessarily","restricted","to","a","single","cell",".","For","example",",","cell","communication","occurs","among","more","than","one","cell",",","but","occurs","at","the","cellular","level","."),3969098). assertion_content_comment('tOboGo_RegulationOfCellularProteinMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","protein",",","occurring","at","the","level","of","an","individual","cell","."),3972418). assertion_content_comment('tOboGo_RegulationOfCellularRespiration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cellular","respiration",",","the","enzymatic","release","of","energy","from","organic","compounds","."),4096187). assertion_content_comment('tOboGo_RegulationOfCellularResponseToGrowthFactorStimulus',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","a","change","in","state","or","activity","of","a","cell","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","growth","factor","stimulus","."),4145294). assertion_content_comment('tOboGo_RegulationOfCellularResponseToStress',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","cellular","response","to","stress",".","Cellular","response","to","stress","is","a","change","in","state","or","activity","of","a","cell","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","stimulus","indicating","the","organism","is","under","stress",".","The","stress","is","usually",",","but","not","necessarily",",","exogenous","(","e.g",".","temperature",",","humidity",",","ionizing","radiation",")"),4010945). assertion_content_comment('tOboGo_RegulationOfCellWallChitinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cell","wall","chitin","."),4064954). assertion_content_comment('tOboGo_RegulationOfCellWallChitinCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cell","wall","chitin","."),4075655). assertion_content_comment('tOboGo_RegulationOfCellWallChitinMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","chitin","in","a","cell","wall","."),4064948). assertion_content_comment('tOboGo_RegulationOfCellWallMacromoleculeMetabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","cell","wall","macromolecule","metabolism",".","Cell","wall","macromolecule","metabolic","processes","are","the","chemical","reactions","and","pathways","involving","macromolecules","forming",",","or","destined","to","form",",","part","of","the","cell","wall",".","A","cell","wall","is","a","rigid","or","semi-rigid","envelope","lying","outside","the","cell","membrane","of","plant",",","fungal","and","most","prokaryotic","cells",",","maintaining","their","shape","and","protecting","them","from","osmotic","lysis","."),4035743). assertion_content_comment('tOboGo_RegulationOfCentralBCellAnergy',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","central","B","cell","anergy","."),3999878). assertion_content_comment('tOboGo_RegulationOfCentralBCellDeletion',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","central","B","cell","deletion","."),3999448). assertion_content_comment('tOboGo_RegulationOfCentralBCellToleranceInduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","central","B","cell","tolerance","induction","."),3999444). assertion_content_comment('tOboGo_RegulationOfCentralToleranceInduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","central","tolerance","induction","."),3995428). assertion_content_comment('tOboGo_RegulationOfCentrioleReplication',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","of","a","daughter","centriole","of","an","existing","centriole","."),4098740). assertion_content_comment('tOboGo_RegulationOfCentromereComplexAssembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","centromere","complex","assembly",",","the","aggregation",",","arrangement","and","bonding","together","of","proteins","and","centromeric","DNA","molecules","to","form","a","centromeric","protein-DNA","complex","."),4151637). assertion_content_comment('tOboGo_RegulationOfCentromericSisterChromatidCohesion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","sister","chromatid","cohesion","in","the","centromeric","region","of","a","chromosome","."),4131023). assertion_content_comment('tOboGo_RegulationOfCentrosomeCycle',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","centrosome","cycle",",","the","processes","of","centrosome","duplication","and","separation","."),4036447). assertion_content_comment('tOboGo_RegulationOfCentrosomeDuplication',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","centrosome","duplication",".","Centrosome","duplication","is","the","replication","of","a","centrosome",",","a","structure","comprised","of","a","pair","of","centrioles","and","peri-centriolar","material","from","which","a","microtubule","spindle","apparatus","is","organized","."),4036450). assertion_content_comment('tOboGo_RegulationOfCeramideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ceramide","biosynthetic","process","."),4098385). assertion_content_comment('tOboGo_RegulationOfCerebellarGranuleCellPrecursorProliferation',s("The","process","that","modulates","the","frequency",",","rate","or","extent","of","granule","cell","precursor","proliferation","."),4047901). assertion_content_comment('tOboGo_RegulationOfCGMPBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cGMP","."),4050561). assertion_content_comment('tOboGo_RegulationOfCGMPCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cGMP","."),4050650). assertion_content_comment('tOboGo_RegulationOfCGMPMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","cGMP","."),4050557). assertion_content_comment('tOboGo_RegulationOfChemokineBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","chemokines","."),4096955). assertion_content_comment('tOboGo_RegulationOfChemokineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","chemokine","production","."),4066954). assertion_content_comment('tOboGo_RegulationOfChemokineSecretion',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","chemokine","secretion",",","the","regulated","release","of","chemokines","from","a","cell","or","group","of","cells","."),4084090). assertion_content_comment('tOboGo_RegulationOfChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","."),3997981). assertion_content_comment('tOboGo_RegulationOfChitinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","chitin","."),4064931). assertion_content_comment('tOboGo_RegulationOfChitinMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","chitin","."),4064858). assertion_content_comment('tOboGo_RegulationOfChlorophyllBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","chlorophyll",",","any","compound","of","magnesium","complexed","in","a","porphyrin","(","tetrapyrrole",")","ring","and","which","functions","as","a","photosynthetic","pigment",",","from","less","complex","precursors","."),4031309). assertion_content_comment('tOboGo_RegulationOfChlorophyllCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","chlorophyll","."),4031809). assertion_content_comment('tOboGo_RegulationOfChlorophyllMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","chlorophyll","."),4031306). assertion_content_comment('tOboGo_RegulationOfCholesterolBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cholesterol","."),4088795). assertion_content_comment('tOboGo_RegulationOfCholesterolEfflux',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cholesterol","efflux",".","Cholesterol","efflux","is","the","directed","movement","of","cholesterol",",","cholest-5-en-3-beta-ol",",","out","of","a","cell","or","organelle","."),4037312). assertion_content_comment('tOboGo_RegulationOfCholesterolEsterification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cholesterol","esterification",".","Cholesterol","esterification","is","the","lipid","modification","process","in","which","a","sterol","ester","is","formed","by","the","combination","of","a","carboxylic","acid","(","often","a","fatty","acid",")","and","cholesterol",".","In","the","blood","this","process","is","associated","with","the","conversion","of","free","cholesterol","into","cholesteryl","ester",",","which","is","then","sequestered","into","the","core","of","a","lipoprotein","particle","."),4037149). assertion_content_comment('tOboGo_RegulationOfCholesterolHomeostasis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cholesterol","homeostasis","."),4141375). assertion_content_comment('tOboGo_RegulationOfCholesterolImport',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","cholesterol","import",".","Cholesterol","import","is","the","directed","movement","of","cholesterol","into","a","cell","or","organelle","."),4111668). assertion_content_comment('tOboGo_RegulationOfCholesterolMetabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","cholesterol","metabolism",",","the","chemical","reactions","and","pathways","involving","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4088792). assertion_content_comment('tOboGo_RegulationOfCholesterolStorage',s("Any","process","that","modulates","the","rate","or","extent","of","cholesterol","storage",".","Cholesterol","storage","is","the","accumulation","and","maintenance","in","cells","or","tissues","of","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4037495). assertion_content_comment('tOboGo_RegulationOfCholesterolTransporterActivity',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","cholesterol","transporter","activity","."),4160915). assertion_content_comment('tOboGo_RegulationOfCholesterolTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","cholesterol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4037309). assertion_content_comment('tOboGo_RegulationOfChondrocyteDevelopment',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","process","whose","specific","outcome","is","the","progression","of","a","chondrocyte","over","time",",","from","its","commitment","to","its","mature","state",".","Chondrocyte","development","does","not","include","the","steps","involved","in","committing","a","chondroblast","to","a","chondrocyte","fate","."),4135886). assertion_content_comment('tOboGo_RegulationOfChromatinAssemblyOrDisassembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chromatin","assembly","or","disassembly","."),3982700). assertion_content_comment('tOboGo_RegulationOfChromatinAssembly',s("Any","process","the","modulates","the","frequency",",","rate","or","extent","of","chromatin","assembly",".","Chromatin","assembly","is","the","assembly","of","DNA",",","histone","proteins",",","and","other","associated","proteins","into","chromatin","structure",",","beginning","with","the","formation","of","the","basic","unit",",","the","nucleosome",",","followed","by","organization","of","the","nucleosomes","into","higher","order","structures",",","ultimately","giving","rise","to","a","complex","organization","of","specific","domains","within","the","nucleus","."),4036858). assertion_content_comment('tOboGo_RegulationOfChromatinBinding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chromatin","binding",".","Chromatin","binding","is","the","selective","interaction","with","chromatin",",","the","network","of","fibers","of","DNA","and","protein","that","make","up","the","chromosomes","of","the","eukaryotic","nucleus","during","interphase","."),4378524). assertion_content_comment('tOboGo_RegulationOfChromatinDisassembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chromatin","disassembly",".","Chromatin","disassembly","is","the","controlled","breakdown","of","chromatin","from","a","higher","order","structure","into","its","simpler","subcomponents",",","DNA",",","histones",",","and","other","proteins","."),4036847). assertion_content_comment('tOboGo_RegulationOfChromatinSilencingAtCentromere',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chromatin","silencing","at","the","centromere",".","Chromatin","silencing","at","the","centromere","is","the","repression","of","transcription","of","centromeric","DNA","by","altering","the","structure","of","chromatin","."),4150135). assertion_content_comment('tOboGo_RegulationOfChromatinSilencingAtRDNA',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","repression","of","transcription","of","ribosomal","DNA","by","altering","the","structure","of","chromatin","."),4136085). assertion_content_comment('tOboGo_RegulationOfChromatinSilencingAtTelomere',s("Any","process","that","affects","the","rate",",","extent","or","location","of","chromatin","silencing","at","telomeres","."),4057638). assertion_content_comment('tOboGo_RegulationOfChromatinSilencingBySmallRNA',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chromatin","silencing","by","small","RNA",".","Chromatin","silencing","by","small","RNA","is","the","repression","of","transcription","by","conversion","of","large","regions","of","DNA","into","heterochromatin",",","directed","by","small","RNAs","sharing","sequence","identity","to","the","repressed","region","."),4035052). assertion_content_comment('tOboGo_RegulationOfChromatinSilencing',s("Any","process","that","affects","the","rate",",","extent","or","location","of","chromatin","silencing","."),4035037). assertion_content_comment('tOboGo_RegulationOfChromosomeCondensation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","chromosome","condensation",",","the","progressive","compaction","of","dispersed","interphase","chromatin","into","threadlike","chromosomes","prior","to","mitotic","or","meiotic","nuclear","division",",","or","during","apoptosis",",","in","eukaryotic","cells","."),4111418). assertion_content_comment('tOboGo_RegulationOfChromosomeOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","chromosome","."),3975631). assertion_content_comment('tOboGo_RegulationOfChromosomeSegregation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chromosome","segregation",",","the","process","in","which","genetic","material",",","in","the","form","of","chromosomes",",","is","organized","and","then","physically","separated","and","apportioned","to","two","or","more","sets","."),4012979). assertion_content_comment('tOboGo_RegulationOfChronicInflammatoryResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","chronic","inflammatory","response","."),3995622). assertion_content_comment('tOboGo_RegulationOfChronicInflammatoryResponseToAntigenicStimulus',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","chronic","inflammatory","response","to","an","antigenic","stimulus","."),4000620). assertion_content_comment('tOboGo_RegulationOfChylomicronRemnantClearance',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","chylomicron","remnant","clearance",".","Chylomicron","clearance","is","the","process","in","which","a","chylomicron","remnant","is","removed","from","the","blood","via","receptor-mediated","endocytosis","into","liver","cells","and","its","constituent","parts","degraded","."),4150803). assertion_content_comment('tOboGo_RegulationOfChylomicronRemodeling',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","chylomicron","remodeling",".","Chylomicron","remodeling","is","the","acquisition",",","loss","or","modification","of","a","protein","or","lipid","within","a","chylomicron",",","including","the","hydrolysis","of","triglyceride","by","lipoprotein","lipase","and","the","subsequent","loss","of","free","fatty","acid","."),4150781). assertion_content_comment('tOboGo_RegulationOfCiliumBeatFrequencyInvolvedInCiliaryMotility',s("Any","process","that","modulates","the","frequency","of","cilium","beating","involved","in","ciliary","motility","."),4160011). assertion_content_comment('tOboGo_RegulationOfCiliumBeatFrequency',s("Any","process","that","modulates","the","frequency","of","cilium","movement",",","the","directed",",","self-propelled","movement","of","a","cilium","."),4194105). assertion_content_comment('tOboGo_RegulationOfCiliumMovementInvolvedInCellMotility',s("Any","process","that","modulates","the","rate","frequency","or","extent","of","cilium","movement","involved","in","ciliary","motility","."),4115719). assertion_content_comment('tOboGo_RegulationOfCiliumMovement',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","cilium","movement",",","the","directed",",","self-propelled","movement","of","a","cilium","."),4005854). assertion_content_comment('tOboGo_RegulationOfCircadianRhythm',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","circadian","rhythm",".","A","circadian","rhythm","is","a","biological","process","in","an","organism","that","recurs","with","a","regularity","of","approximately","24","hours","."),4036791). assertion_content_comment('tOboGo_RegulationOfCircadianSleepWakeCycleREMSleep',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","rapid","eye","movement","(","REM",")","sleep","."),4079653). assertion_content_comment('tOboGo_RegulationOfCircadianSleepWakeCycle',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","circadian","sleep/wake","cycle","."),4036796). assertion_content_comment('tOboGo_RegulationOfCircadianSleepWakeCycleSleep',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","sleep",";","a","readily","reversible","state","of","reduced","awareness","and","metabolic","activity","that","occurs","periodically","in","many","animals","."),4079649). assertion_content_comment('tOboGo_RegulationOfCircadianSleepWakeCycleWakefulness',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","wakeful","phase","of","the","circadian","sleep/wake","cycle",".","The","wakeful","phase","is","the","part","of","the","circadian","sleep/wake","cycle","where","the","organism","is","not","asleep","."),4036799). assertion_content_comment('tOboGo_RegulationOfCleistotheciumDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cleistothecium","development",",","a","process","that","leads","to","the","formation","of","a","cleistothecium",".","The","cleistothecium","is","a","closed","sexual","fruiting","body","that","contains","ascospores","in","linear","asci",",","characteristic","of","some","filamentous","Ascomycete","fungi","such","as","members","of","the","genera","Aspergillus","and","Emericella","."),4132464). assertion_content_comment('tOboGo_RegulationOfCoagulation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","coagulation",",","the","process","in","which","a","fluid","solution",",","or","part","of","it",",","changes","into","a","solid","or","semisolid","mass","."),3996527). assertion_content_comment('tOboGo_RegulationOfCoenzymeABiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","coenzyme","A","."),4148840). assertion_content_comment('tOboGo_RegulationOfCoenzymeAndProstheticGroupMetabolicProcess',s("OBSOLETE",".","Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","coenzymes","and","prosthetic","groups","."),4308201). assertion_content_comment('tOboGo_RegulationOfCoenzymeMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","coenzyme","."),4025728). assertion_content_comment('tOboGo_RegulationOfCofactorMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","cofactor","."),4025724). assertion_content_comment('tOboGo_RegulationOfCohesinLocalizationToChromatin',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","in","which","a","cohesin","complex","is","transported","to",",","or","maintained","at",",","a","part","of","a","chromosome","that","is","organized","into","chromatin","."),4125909). assertion_content_comment('tOboGo_RegulationOfCollagenBinding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","collagen","binding","."),4338662). assertion_content_comment('tOboGo_RegulationOfCollagenCatabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","collagen","catabolism",".","Collagen","catabolism","is","the","proteolytic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","collagen","in","the","extracellular","matrix","."),4026942). assertion_content_comment('tOboGo_RegulationOfCollagenMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","metabolism","of","collagen",",","any","of","a","group","of","fibrous","proteins","of","very","high","tensile","strength","that","form","the","main","component","of","connective","tissue","in","animals","."),4026861). assertion_content_comment('tOboGo_RegulationOfCollateralSproutingInAbsenceOfInjury',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","collateral","sprouting","in","the","absence","of","injury","."),4107025). assertion_content_comment('tOboGo_RegulationOfCollateralSproutingOfInjuredAxon',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","collateral","sprouting","of","an","injured","axon","."),4106973). assertion_content_comment('tOboGo_RegulationOfCollateralSproutingOfIntactAxonInResponseToInjury',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","collateral","sprouting","of","an","intact","axon","as","a","result","of","injury","to","an","axon","."),4106870). assertion_content_comment('tOboGo_RegulationOfCollateralSprouting',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","collateral","sprouting","."),4106669). assertion_content_comment('tOboGo_RegulationOfComplementActivationAlternativePathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","alternative","pathway","of","complement","activation","."),4046279). assertion_content_comment('tOboGo_RegulationOfComplementActivationClassicalPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","classical","pathway","of","complement","activation","."),4046256). assertion_content_comment('tOboGo_RegulationOfComplementActivationLectinPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","lectin","pathway","of","complement","activation","."),3986271). assertion_content_comment('tOboGo_RegulationOfComplementActivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","complement","activation","."),3986255). assertion_content_comment('tOboGo_RegulationOfCompoundEyeConeCellFateSpecification',s("Any","process","that","mediates","the","specification","of","a","cell","into","a","compound","eye","cone","cell","."),4077991). assertion_content_comment('tOboGo_RegulationOfCompoundEyePhotoreceptorDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","compound","eye","photoreceptor","development","."),4085745). assertion_content_comment('tOboGo_RegulationOfCompoundEyePigmentation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","compound","eye","."),4104231). assertion_content_comment('tOboGo_RegulationOfCompoundEyeRetinalCellProgrammedCellDeath',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","programmed","cell","death","that","occurs","in","the","compound","eye","retina","."),4099113). assertion_content_comment('tOboGo_RegulationOfConidiophoreDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","conidiophore","development",",","a","process","that","leads","to","the","formation","of","a","conidiophore",".","The","conidiophore","is","a","specialized","hypha","that","extends","aerially","from","the","growth","substrate","and","bears","conidia",",","or","asexual","spores","."),4132404). assertion_content_comment('tOboGo_RegulationOfConidiophoreStalkDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","conidiophore","stalk","development",",","a","process","that","leads","to","the","formation","of","a","conidiophore","stalk",".","The","conidiophore","stalk","is","part","of","a","specialized","hypha","that","extends","aerially","from","the","growth","substrate","and","supports","structures","from","which","conidia",",","or","asexual","spores",",","develop","."),4132520). assertion_content_comment('tOboGo_RegulationOfConidiumFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","conidium","formation",",","a","processes","leading","to","the","production","of","a","type","of","asexual","non-motile","reproductive","spore","of","fungi","via","mitosis","at","the","tip","or","side","of","hyphae","or","on","special","spore-producing","structures","called","conidiophores","."),4148070). assertion_content_comment('tOboGo_RegulationOfConjugation',s("Any","process","that","modulates","the","rate","or","frequency","of","conjugation",",","the","union","or","introduction","of","genetic","information","from","compatible","mating","types","that","results","in","a","genetically","different","individual","."),3977481). assertion_content_comment('tOboGo_RegulationOfConjugationWithCellularFusionBySignalTransduction',s("The","series","of","molecular","signals","that","bring","about","the","relay",",","amplification","or","dampening","of","a","signal","generated","in","response","to","a","cue",",","such","as","starvation","or","pheromone","exposure",",","in","organisms","that","undergo","conjugation","with","cellular","fusion","."),3977487). assertion_content_comment('tOboGo_RegulationOfConjugationWithCellularFusion',s("Any","process","that","modulates","the","rate","or","frequency","of","conjugation","with","cellular","fusion","."),3977484). assertion_content_comment('tOboGo_RegulationOfConnectiveTissueGrowthFactorBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","connective","tissue","growth","factor","."),4089012). assertion_content_comment('tOboGo_RegulationOfConnectiveTissueGrowthFactorProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","connective","tissue","growth","factor","production","."),4066982). assertion_content_comment('tOboGo_RegulationOfContractileRingContractionInvolvedInCellCycleCytokinesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","contraction","of","the","actomyosin","ring","involved","in","cytokinesis","that","takes","place","as","part","of","a","cell","cycle","."),4058125). assertion_content_comment('tOboGo_RegulationOfCOPIIVesicleCoating',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","addition","of","COPII","proteins","and","adaptor","proteins","to","ER","membranes","during","the","formation","of","transport","vesicles",",","forming","a","vesicle","coat","."),4005371). assertion_content_comment('tOboGo_RegulationOfCOPIIVesicleUncoating',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","COPII","vesicle","uncoating",",","the","process","in","which","COPII","vesicle","coat","proteins","are","disassembled",",","and","released","."),4148944). assertion_content_comment('tOboGo_RegulationOfCoreceptorActivityInvolvedInEpidermalGrowthFactorReceptorSignalingPathway',s("Any","process","that","modulates","the","rate","or","frequency","of","coreceptor","activity","involved","in","epidermal","growth","factor","receptor","signaling","pathway","."),4161142). assertion_content_comment('tOboGo_RegulationOfCoreceptorActivity',s("Any","process","that","modulates","the","rate","or","frequency","of","coreceptor","activity",",","combining","with","an","extracellular","or","intracellular","messenger",",","and","in","cooperation","with","a","nearby","primary","receptor",",","initiating","a","change","in","cell","activity","."),4161140). assertion_content_comment('tOboGo_RegulationOfCorticotropinSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","corticotropic","hormone","from","a","cell","or","group","of","cells","."),4118479). assertion_content_comment('tOboGo_RegulationOfCortisolBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cortisol","biosynthetic","process","."),4138860). assertion_content_comment('tOboGo_RegulationOfCortisolSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","cortisol","from","a","cell","or","group","of","cells","."),4118400). assertion_content_comment('tOboGo_RegulationOfCrystalCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","crystal","cell","differentiation","."),4078038). assertion_content_comment('tOboGo_RegulationOfCullinDeneddylation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","cullin","deneddylation",",","the","modification","of","cullins","by","removal","of","ubiquitin-like","protein","NEDD8","(","RUB1",")"),4111408). assertion_content_comment('tOboGo_RegulationOfCumulusCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ovarian","cumulus","cell","differentiation","."),4088189). assertion_content_comment('tOboGo_RegulationOfCuticlePigmentation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","cuticle","of","an","organism","."),4104093). assertion_content_comment('tOboGo_RegulationOfCyanophoreDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cyanophore","differentiation","."),4104865). assertion_content_comment('tOboGo_RegulationOfCyclaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cyclase","activity","."),4027752). assertion_content_comment('tOboGo_RegulationOfCyclicNucleotideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cyclic","nucleotides","."),4027624). assertion_content_comment('tOboGo_RegulationOfCyclicNucleotideCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cyclic","nucleotides","."),4050112). assertion_content_comment('tOboGo_RegulationOfCyclicNucleotideMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","cyclic","nucleotides","."),4027528). assertion_content_comment('tOboGo_RegulationOfCyclinCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cyclin","catabolic","process","."),4143814). assertion_content_comment('tOboGo_RegulationOfCytokineActivity',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","activity","of","a","molecule","that","controls","the","survival",",","growth",",","differentiation","and","effector","function","of","tissues","and","cells","."),4160572). assertion_content_comment('tOboGo_RegulationOfCytokineBiosyntheticProcessInvolvedInImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","cytokine","biosynthesis","that","contributes","to","an","immune","response","."),3996820). assertion_content_comment('tOboGo_RegulationOfCytokineBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","cytokines","."),3996813). assertion_content_comment('tOboGo_RegulationOfCytokineProductionInvolvedInImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","cytokine","production","that","contributes","to","an","immune","response","."),3996799). assertion_content_comment('tOboGo_RegulationOfCytokineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","a","cytokine","."),3984233). assertion_content_comment('tOboGo_RegulationOfCytokineSecretionInvolvedInImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","cytokine","secretion","contributing","to","an","immune","response","."),3996986). assertion_content_comment('tOboGo_RegulationOfCytokineSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","cytokines","from","a","cell","or","group","of","cells","."),3996983). assertion_content_comment('tOboGo_RegulationOfCytokinesisActomyosinContractileRingAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cytokinesis",",","actomyosin","contractile","ring","assembly","."),4142068). assertion_content_comment('tOboGo_RegulationOfCytokinesisByBinaryFission',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cytokinesis","by","binary","fission","."),4140496). assertion_content_comment('tOboGo_RegulationOfCytokinesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","division","of","the","cytoplasm","of","a","cell","and","its","separation","into","two","daughter","cells","."),4028448). assertion_content_comment('tOboGo_RegulationOfCytokineticCellSeparation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","process","of","physically","separating","progeny","cells","contributing","to","cytokinesis",";","this","may","involve","enzymatic","digestion","of","septum","or","cell","wall","components","."),4028454). assertion_content_comment('tOboGo_RegulationOfCytokineticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","cytokinetic","process","."),4028451). assertion_content_comment('tOboGo_RegulationOfCytokininMediatedSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","cytokinin","."),4148745). assertion_content_comment('tOboGo_RegulationOfCytolysisBySymbiontOfHostCells',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","cytolysis","by","that","organism","of","cells","in","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3985884). assertion_content_comment('tOboGo_RegulationOfCytolysisInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","cytolysis","by","that","organism","of","cells","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3985879). assertion_content_comment('tOboGo_RegulationOfCytolysisInOtherOrganism',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","cytolysis","by","an","organism","of","cells","in","another","organism","."),3985874). assertion_content_comment('tOboGo_RegulationOfCytolysis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","rupture","of","cell","membranes","and","the","loss","of","cytoplasm","."),4079269). assertion_content_comment('tOboGo_RegulationOfCytoplasmicMicrotubuleDepolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cytoplasmic","microtubule","depolymerization","."),4034962). assertion_content_comment('tOboGo_RegulationOfCytoplasmicMRNAProcessingBodyAssembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","aggregation",",","arrangement","and","bonding","together","of","proteins","and","RNA","molecules","to","form","a","cytoplasmic","mRNA","processing","body","."),4028217). assertion_content_comment('tOboGo_RegulationOfCytoskeletonOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","."),4004436). assertion_content_comment('tOboGo_RegulationOfCytoskeletonPolarizationInvolvedInGrowthPlateCartilageChondrocyteDivision',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","receptor","on","the","surface","of","the","target","cell","that","modulates","the","rate",",","frequency",",","or","extent","of","the","polarization","of","cytoskeletal","structures","in","a","growth","plate","cartilage","chondrocyte",".","This","process","results","in","the","oriented","division","of","the","cell","."),4004501). assertion_content_comment('tOboGo_RegulationOfCytoskeleton',s("OBSOLETE",".","Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","organization",",","biogenesis","or","maintenance","of","the","cytoskeleton","."),4235369). assertion_content_comment('tOboGo_RegulationOfCytotoxicTCellDegranulation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","cytotoxic","T","cell","degranulation","."),4095553). assertion_content_comment('tOboGo_RegulationOfCytotoxicTCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cytotoxic","T","cell","differentiation","."),4088442). assertion_content_comment('tOboGo_RegulationOfDauerLarvalDevelopment',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","dauer","larval","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","dauer","larva","over","time",",","through","the","facultative","diapause","of","the","dauer","(","enduring",")","larval","stage",",","with","specialized","traits","adapted","for","dispersal","and","long-term","survival",",","with","elevated","stress","resistance","and","without","feeding","."),4113544). assertion_content_comment('tOboGo_RegulationOfDecapentaplegicReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","decapentaplegic","receptor","signaling","pathway",".","The","decapentaplegic","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","a","decapentaplegic","receptor","binding","to","one","of","its","physiological","ligands","."),4150423). assertion_content_comment('tOboGo_RegulationOfDefecation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","defecation","."),4140004). assertion_content_comment('tOboGo_RegulationOfDefenseResponseByCalloseDeposition',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","defense","response","by","callose","deposition","."),4138601). assertion_content_comment('tOboGo_RegulationOfDefenseResponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","defense","response","."),3983192). assertion_content_comment('tOboGo_RegulationOfDefenseResponseToFungusIncompatibleInteraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","defense","response","to","fungus",",","incompatible","interaction","."),4138560). assertion_content_comment('tOboGo_RegulationOfDefenseResponseToInsect',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","defense","response","to","insect","."),4138906). assertion_content_comment('tOboGo_RegulationOfDefenseResponseToVirusByHost',s("Any","host","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","antiviral","response","of","a","host","cell","or","organism","."),4277170). assertion_content_comment('tOboGo_RegulationOfDefenseResponseToVirusByVirus',s("Any","viral","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","antiviral","response","of","the","host","cell","or","organism","."),4236879). assertion_content_comment('tOboGo_RegulationOfDefenseResponseToVirus',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","antiviral","response","of","a","cell","or","organism","."),4101390). assertion_content_comment('tOboGo_RegulationOfDefinitiveErythrocyteDifferentiation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","definitive","erythrocyte","differentiation",".","Definitive","erythrocyte","differentiation","occurs","as","part","of","the","process","of","definitive","hemopoiesis","."),4026998). assertion_content_comment('tOboGo_RegulationOfDendriteDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","dendrite","development","."),4100978). assertion_content_comment('tOboGo_RegulationOfDendriteMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","dendrite","morphogenesis","."),4100981). assertion_content_comment('tOboGo_RegulationOfDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","dendritic","cell","antigen","processing","and","presentation","."),3994656). assertion_content_comment('tOboGo_RegulationOfDendriticCellChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","dendritic","cell","chemotaxis","."),4144659). assertion_content_comment('tOboGo_RegulationOfDendriticCellCytokineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","dendritic","cell","cytokine","production","."),3997186). assertion_content_comment('tOboGo_RegulationOfDendriticCellDendriteAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","dendritic","cell","dendrite","assembly","."),4145003). assertion_content_comment('tOboGo_RegulationOfDendriticSpineDevelopment',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","dendritic","spine","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","dendritic","spine","over","time",",","from","its","formation","to","the","mature","structure","."),4113115). assertion_content_comment('tOboGo_RegulationOfDendriticSpineMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","dendritic","spine","morphogenesis",",","the","process","in","which","the","anatomical","structures","of","a","dendritic","spine","are","generated","and","organized",".","A","dendritic","spine","is","a","protrusion","from","a","dendrite","and","a","specialized","subcellular","compartment","involved","in","synaptic","transmission","."),4113130). assertion_content_comment('tOboGo_RegulationOfDeoxyribonucleaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","deoxyribonuclease","activity",",","the","hydrolysis","of","ester","linkages","within","deoxyribonucleic","acid","."),4330502). assertion_content_comment('tOboGo_RegulationOfDephosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","removal","of","phosphate","groups","from","a","molecule","."),4071102). assertion_content_comment('tOboGo_RegulationOfDermatomeDevelopment',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","progression","of","the","dermatome","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","dermatome","is","the","portion","of","a","somite","that","will","form","skin","."),4135896). assertion_content_comment('tOboGo_RegulationOfDeterminationOfDorsalIdentity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","determination","of","dorsal","identity","."),4139207). assertion_content_comment('tOboGo_RegulationOfDevelopmentalGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","developmental","growth","."),4004409). assertion_content_comment('tOboGo_RegulationOfDevelopmentalPigmentation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","developmental","process","that","results","in","the","deposition","of","coloring","matter","in","an","organism","."),4086920). assertion_content_comment('tOboGo_RegulationOfDevelopmentalProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","development",",","the","biological","process","whose","specific","outcome","is","the","progression","of","a","multicellular","organism","over","time","from","an","initial","condition","(","e.g",".","a","zygote",",","or","a","young","adult",")","to","a","later","condition","(","e.g",".","a","multicellular","animal","or","an","aged","adult",")"),3985467). assertion_content_comment('tOboGo_RegulationOfDevelopmentHeterochronic',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","progression","an","integrated","living","unit",":","an","anatomical","structure","(","which","may","be","a","subcellular","structure",",","cell",",","tissue",",","or","organ",")",",","or","organism","over","time","from","an","initial","condition","to","a","later","condition","at","a","consistent","predetermined","time","point","during","its","development","."),3989745). assertion_content_comment('tOboGo_RegulationOfDevelopmentOfSymbiontInHost',s("Any","process","in","which","the","symbiont","regulates","its","progression","from","an","initial","condition","to","a","later","condition",",","within","the","cells","or","tissues","of","the","host","organism",".","This","may","(","but","not","necessarily",")","include","a","filamentous","growth","form",",","and","also","can","include","secretion","of","proteases","and","lipases","to","break","down",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4097780). assertion_content_comment('tOboGo_RegulationOfDigestiveSystemProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","digestive","system","process",",","a","physical",",","chemical",",","or","biochemical","process","carried","out","by","living","organisms","to","break","down","ingested","nutrients","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),4035345). assertion_content_comment('tOboGo_RegulationOfDipeptideTransport',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","dipeptide","transport",".","Dipeptide","transport","is","the","directed","movement","of","a","dipeptide",",","a","combination","of","two","amino","acids","by","means","of","a","peptide","(","-CO-NH-",")","link",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4150266). assertion_content_comment('tOboGo_RegulationOfDiuresis',s("OBSOLETE",".","Any","process","that","modulates","the","rate","of","diuresis",".","Diuresis","is","the","process","of","renal","water","excretion","."),4193980). assertion_content_comment('tOboGo_RegulationOfDNABinding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","binding",".","DNA","binding","is","any","process","in","which","a","gene","product","interacts","selectively","with","DNA","(","deoxyribonucleic","acid",")"),4160152). assertion_content_comment('tOboGo_RegulationOfDNABiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","biosynthetic","process","."),4140151). assertion_content_comment('tOboGo_RegulationOfDNADamageCheckpoint',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","DNA","damage","checkpoint","."),4139576). assertion_content_comment('tOboGo_RegulationOfDNADamageResponseSignalTransductionByP53ClassMediator',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","cascade","of","processes","induced","by","the","cell","cycle","regulator","phosphoprotein","p53",",","or","an","equivalent","protein",",","in","response","to","the","detection","of","DNA","damage","."),4094560). assertion_content_comment('tOboGo_RegulationOfDNAEndoreduplication',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","endoreduplication","."),4064816). assertion_content_comment('tOboGo_RegulationOfDNALigation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","ligation",",","the","re-formation","of","a","broken","phosphodiester","bond","in","the","DNA","backbone",",","carried","out","by","DNA","ligase","."),4119470). assertion_content_comment('tOboGo_RegulationOfDNAMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","DNA","."),3969147). assertion_content_comment('tOboGo_RegulationOfDNAMethylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","covalent","transfer","of","a","methyl","group","to","either","N-6","of","adenine","or","C-5","or","N-4","of","cytosine","."),4096427). assertion_content_comment('tOboGo_RegulationOfDNARecombination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","recombination",",","a","DNA","metabolic","process","in","which","a","new","genotype","is","formed","by","reassortment","of","genes","resulting","in","gene","combinations","different","from","those","that","were","present","in","the","parents","."),3969151). assertion_content_comment('tOboGo_RegulationOfDNARepair',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","repair","."),4010948). assertion_content_comment('tOboGo_RegulationOfDNAReplicationInitiationInvolvedInPlasmidCopyNumberMaintenance',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","initiation","of","plasmid","DNA","replication","that","contributes","to","copy","number","maintenance","."),4114268). assertion_content_comment('tOboGo_RegulationOfDNAReplicationInvolvedInSPhase',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","replication","that","contributes","to","the","progression","through","S","phase","of","the","cell","cycle","."),4027823). assertion_content_comment('tOboGo_RegulationOfDNAReplication',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","replication","."),4010828). assertion_content_comment('tOboGo_RegulationOfDNAReplicationTermination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","replication","termination","."),4144165). assertion_content_comment('tOboGo_RegulationOfDNAStrandElongation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","DNA","strand","elongation",".","DNA","strand","elongation","is","the","DNA","metabolic","process","in","which","a","DNA","strand","is","synthesized","by","adding","nucleotides","to","the","3","'","end","of","an","existing","DNA","stand","."),4114936). assertion_content_comment('tOboGo_RegulationOfDolicholBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","dolichol","biosynthesis",".","Dolichol","biosynthesis","consists","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","dolichols",",","any","2",",","3-dihydropolyprenol","derived","from","four","or","more","linked","isoprene","units","."),4025514). assertion_content_comment('tOboGo_RegulationOfDopamineMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","dopamine","."),4081656). assertion_content_comment('tOboGo_RegulationOfDopamineReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","dopamine","receptor","signaling","pathway","activity",".","A","dopamine","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","a","dopamine","receptor","binding","to","one","of","its","physiological","ligands","."),4108339). assertion_content_comment('tOboGo_RegulationOfDopamineSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","dopamine","."),4039464). assertion_content_comment('tOboGo_RegulationOfDopamineUptake',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","the","catecholamine","neurotransmitter","dopamine","into","a","cell","."),4121287). assertion_content_comment('tOboGo_RegulationOfDoubleFertilizationFormingAZygoteAndEndosperm',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","double","fertilization","forming","a","zygote","and","endosperm",".","Double","fertilization","forming","a","zygote","and","endosperm","is","a","type","of","fertilization","where","one","of","the","two","sperm","nuclei","from","the","pollen","tube","fuses","with","the","egg","nucleus","to","form","a","2n","zygote",",","and","the","other","fuses","with","the","two","polar","nuclei","to","form","the","3n","primary","endosperm","nucleus","and","then","develops","into","the","endosperm",".","The","ploidy","level","of","the","2n","zygote","and","3n","primary","endosperm","nucleus","is","determined","by","the","ploidy","level","of","the","parents","involved",".","An","example","of","this","component","is","found","in","Arabidopsis","thaliana","."),4147690). assertion_content_comment('tOboGo_RegulationOfDynaminPolymerizationInvolvedInMembraneFission',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","membrane","fission","."),4005565). assertion_content_comment('tOboGo_RegulationOfEarlyEndosomeToLateEndosomeTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","early","endosome","to","late","endosome","transport","."),4137606). assertion_content_comment('tOboGo_RegulationOfEarlyStripeMelanocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","early","stripe","melanocyte","differentiation","."),4099934). assertion_content_comment('tOboGo_RegulationOfEcdysteroidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","ecdysteroids","."),4015894). assertion_content_comment('tOboGo_RegulationOfEcdysteroidMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","ecdysteroids",",","a","group","of","polyhydroxylated","ketosteroids","which","initiate","post-embryonic","development",",","including","the","metamorphosis","of","immature","forms","and","the","development","of","the","reproductive","system","and","the","maturation","of","oocytes","in","adult","females","."),4015850). assertion_content_comment('tOboGo_RegulationOfEcdysteroidSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","ecdysteroid","from","a","cell","or","group","of","cells","."),4015736). assertion_content_comment('tOboGo_RegulationOfEclosion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","emergence","of","an","insect","from","a","pupa-case","or","of","a","larva","from","an","egg","."),4015356). assertion_content_comment('tOboGo_RegulationOfEctodermalCellFateSpecification',s("Any","process","that","mediates","the","specification","of","a","cell","into","an","ectoderm","cell","."),4078160). assertion_content_comment('tOboGo_RegulationOfEctodermDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ectoderm","development","."),4078157). assertion_content_comment('tOboGo_RegulationOfEIF2AlphaPhosphorylationByAminoAcidStarvation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","eIF2","alpha","phosphorylation","as","a","cellular","response","to","amino","acid","starvation","."),4110754). assertion_content_comment('tOboGo_RegulationOfEIF2AlphaPhosphorylationByDsRNA',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","eIF2","alpha","phosphorylation","as","a","cellular","response","to","double-stranded","RNA","."),4110718). assertion_content_comment('tOboGo_RegulationOfEIF2AlphaPhosphorylationByEndoplasmicReticulumStress',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","eIF2","alpha","phosphorylation","as","a","cellular","response","to","endoplasmic","reticulum","stress","."),4110732). assertion_content_comment('tOboGo_RegulationOfEIF2AlphaPhosphorylationByHeme',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","eIF2","alpha","phosphorylation","as","a","result","of","heme","levels","."),4036202). assertion_content_comment('tOboGo_RegulationOfElastinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","elastin","."),4118812). assertion_content_comment('tOboGo_RegulationOfElastinCatabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","elastin","catabolism",",","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","elastin","."),4114865). assertion_content_comment('tOboGo_RegulationOfEmbryonicCellShape',s("Any","process","that","modulates","the","surface","configuration","of","an","embryonic","cell","."),4019775). assertion_content_comment('tOboGo_RegulationOfEmbryonicDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","embryonic","development","."),3989728). assertion_content_comment('tOboGo_RegulationOfEmbryoSacCentralCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","female","gametophyte","central","cell","differentiation","."),4091559). assertion_content_comment('tOboGo_RegulationOfEmbryoSacEggCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","embryo","sac","egg","cell","differentiation","."),4091705). assertion_content_comment('tOboGo_RegulationOfEnamelMineralization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","enamel","mineralization",",","the","deposition","of","calcium","salts","in","tooth","enamel","."),4133410). assertion_content_comment('tOboGo_RegulationOfEndocannabinoidSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endocannabinoid","signaling","pathway","."),4138117). assertion_content_comment('tOboGo_RegulationOfEndocrineProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","an","endocrine","process",",","a","process","involving","the","secretion","of","or","response","to","endocrine","hormones",".","An","endocrine","hormone","is","a","hormone","released","into","the","circulatory","system","."),4015402). assertion_content_comment('tOboGo_RegulationOfEndocytosisByExocystLocalization',s("Any","process","in","which","an","exocyst","is","transported","to",",","or","maintained","in",",","a","specific","location","that","results","in","the","modulation","of","endocytosis",".","An","exocyst","is","a","protein","complex","peripherally","associated","with","the","plasma","membrane","that","determines","where","vesicles","dock","and","fuse","."),4284449). assertion_content_comment('tOboGo_RegulationOfEndocytosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endocytosis","."),3989850). assertion_content_comment('tOboGo_RegulationOfEndodeoxyribonucleaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endodeoxyribonuclease","activity",",","the","hydrolysis","of","ester","linkages","within","deoxyribonucleic","acid","by","creating","internal","breaks","."),4330527). assertion_content_comment('tOboGo_RegulationOfEndodermalCellFateSpecification',s("Any","process","that","mediates","the","specification","of","a","cell","into","an","endoderm","cell","."),4078119). assertion_content_comment('tOboGo_RegulationOfEndopeptidaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endopeptidase","activity",",","the","endohydrolysis","of","peptide","bonds","within","proteins","."),4011558). assertion_content_comment('tOboGo_RegulationOfEndoribonucleaseActivity',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","catalysis","of","the","hydrolysis","of","ester","linkages","within","ribonucleic","acid","by","creating","internal","breaks","."),4160877). assertion_content_comment('tOboGo_RegulationOfEndosomeSize',s("Any","process","that","modulates","the","volume","of","an","endosome",",","a","membrane-bounded","organelle","that","carries","materials","newly","ingested","by","endocytosis","."),4025605). assertion_content_comment('tOboGo_RegulationOfEndospermDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endosperm","development","."),4139218). assertion_content_comment('tOboGo_RegulationOfEndothelialCellApoptosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endothelial","cell","apoptosis","."),4143461). assertion_content_comment('tOboGo_RegulationOfEndothelialCellChemotaxisToFibroblastGrowthFactor',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endothelial","cell","chemotaxis","to","fibroblast","growth","factor","."),4145297). assertion_content_comment('tOboGo_RegulationOfEndothelialCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endothelial","cell","differentiation","."),4087102). assertion_content_comment('tOboGo_RegulationOfEndothelialCellMigration',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","orderly","movement","of","an","endothelial","cell","into","the","extracellular","matrix","to","form","an","endothelium","."),4028189). assertion_content_comment('tOboGo_RegulationOfEndothelialCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","endothelial","cell","proliferation","."),3988545). assertion_content_comment('tOboGo_RegulationOfEndothelialMicroparticleFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endothelial","microparticle","formation","."),4143196). assertion_content_comment('tOboGo_RegulationOfEnergyHomeostasis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","energy","homeostasis","."),4145729). assertion_content_comment('tOboGo_RegulationOfEntryOfBacteriumIntoHostCell',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","entry","of","bacterium","into","host","cell","."),4145122). assertion_content_comment('tOboGo_RegulationOfEosinophilChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","eosinophil","chemotaxis","."),4141841). assertion_content_comment('tOboGo_RegulationOfEosinophilDegranulation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","eosinophil","degranulation","."),4093497). assertion_content_comment('tOboGo_RegulationOfEosinophilDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","eosinophil","differentiation","."),4087584). assertion_content_comment('tOboGo_RegulationOfEosinophilExtravasation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","eosinophil","extravasation","."),4141865). assertion_content_comment('tOboGo_RegulationOfEosinophilMigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","eosinophil","migration","."),4141826). assertion_content_comment('tOboGo_RegulationOfEpidermalCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","epidermal","cell","differentiation","."),4032642). assertion_content_comment('tOboGo_RegulationOfEpidermalCellDivision',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","physical","partitioning","and","separation","of","an","epidermal","cell","into","daughter","cells",".","An","epidermal","cell","is","any","of","the","cells","that","make","up","the","epidermis","."),4029628). assertion_content_comment('tOboGo_RegulationOfEpidermalGrowthFactorReceptorActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","EGF","receptor","activity","."),4217327). assertion_content_comment('tOboGo_RegulationOfEpidermalGrowthFactorReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","epidermal","growth","factor","receptor","signaling","pathway","activity","."),4081590). assertion_content_comment('tOboGo_RegulationOfEpidermisDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","epidermis","development","."),4032637). assertion_content_comment('tOboGo_RegulationOfEpinephrineSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","epinephrine","."),4039545). assertion_content_comment('tOboGo_RegulationOfEpinephrineUptake',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","the","neurotransmitter","epinephrine","into","a","cell","."),4121465). assertion_content_comment('tOboGo_RegulationOfEpithelialCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","epithelial","cell","differentiation","."),4006186). assertion_content_comment('tOboGo_RegulationOfEpithelialCellMigrationOpenTrachealSystem',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","epithelial","cell","migration",",","open","tracheal","system","."),4140182). assertion_content_comment('tOboGo_RegulationOfEpithelialCellMigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","epithelial","cell","migration","."),4028661). assertion_content_comment('tOboGo_RegulationOfEpithelialCellProliferationInvolvedInMammaryGlandBudElongation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mammary","gland","bud","epithelial","cell","proliferation","that","results","in","the","elongation","of","the","bud","."),4112005). assertion_content_comment('tOboGo_RegulationOfEpithelialCellProliferationInvolvedInProstateGlandDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","epithelial","cell","proliferation","that","contributes","to","the","progression","of","the","prostate","gland","over","time","."),4110979). assertion_content_comment('tOboGo_RegulationOfEpithelialCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","epithelial","cell","proliferation","."),3988542). assertion_content_comment('tOboGo_RegulationOfEpithelialToMesenchymalTransition',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","epithelial","to","mesenchymal","transition",".","Epithelial","to","mesenchymal","transition","where","an","epithelial","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","."),4027037). assertion_content_comment('tOboGo_RegulationOfErgosterolBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","ergosterol","."),4037845). assertion_content_comment('tOboGo_RegulationOfERK1AndERK2Cascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","ERK1","and","ERK2","cascade","."),4136827). assertion_content_comment('tOboGo_RegulationOfErythrocyteAggregation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","erythrocyte","aggregation","."),4076820). assertion_content_comment('tOboGo_RegulationOfErythrocyteClearance',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","erythrocyte","clearance","."),4076660). assertion_content_comment('tOboGo_RegulationOfErythrocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","erythrocyte","differentiation","."),4024399). assertion_content_comment('tOboGo_RegulationOfErythrophoreDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","erythrophore","differentiation","."),4105050). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfBipolarCellPolarityRegulatingCellShape',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","establishment","of","bipolar","cell","polarity","that","contributes","to","the","shape","of","a","cell","."),4156223). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfBipolarCellPolarity',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","establishment","of","bipolar","cell","polarity",".","Bipolar","organization","is","the","organization","that","is","a","mirror","image","along","an","axis","from","a","plane","."),4135936). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfCellPolarity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","of","cell","polarity","."),4004496). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfCompetenceForTransformation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","process","in","which","a","cell","becomes","able","to","take","up","and","incorporate","extracellular","DNA","into","its","genome","."),4085725). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfContractileRingLocalizationInvolvedInCellCycleCytokinesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","process","in","which","a","contractile","ring","is","assembled","in","a","specific","location","that","contributes","to","cytokinesis","during","cell","cycle","."),4128370). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfMitochondrionLocalizationInvolvedInMitochondrialFission',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","mitochondria","to","the","correct","region","of","the","cell","that","contributes","to","the","process","of","mitochondrial","fission","."),4149199). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfPlanarPolarityInvolvedInNeuralTubeClosure',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","establishment","of","planar","polarity","involved","in","neural","tube","closure",",","the","coordinated","organization","of","groups","of","cells","in","the","plane","of","an","epithelium","that","contributes","to","the","closure","of","the","neural","tube","."),4141637). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfPlanarPolarity',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","establishment","of","planar","polarity",",","the","coordinated","organization","of","groups","of","cells","in","a","tissue",",","such","that","they","all","orient","to","similar","coordinates","."),4004468). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfProteinLocalizationInPlasmaMembrane',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","protein","to","a","specific","location","in","the","plasma","membrane","."),4149554). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfProteinLocalization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","protein","to","a","specific","location","."),3996972). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfProteinLocalizationToChromosome',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","protein","to","a","specific","location","on","a","chromosome","."),4137427). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfProteinLocalizationToTelomere',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","protein","to","a","specific","location","in","the","telomeric","region","of","a","chromosome","."),4137438). assertion_content_comment('tOboGo_RegulationOfEstablishmentOfTurgorInAppressorium',s("Any","process","modulates","the","frequency",",","rate","or","extent","of","turgor","formation","in","the","symbiont","appressorium","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147023). assertion_content_comment('tOboGo_RegulationOfEstablishmentOrMaintenanceOfBipolarCellPolarityRegulatingCellShape',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","or","maintenance","of","bipolar","cell","polarity","regulating","cell","shape","."),4133694). assertion_content_comment('tOboGo_RegulationOfEstablishmentOrMaintenanceOfBipolarCellPolarity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","or","maintenance","of","bipolar","cell","polarity","."),4133691). assertion_content_comment('tOboGo_RegulationOfEstablishmentOrMaintenanceOfCellPolarity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","specification",",","formation","or","maintenance","of","anisotropic","intracellular","organization","or","cell","growth","patterns","."),4004493). assertion_content_comment('tOboGo_RegulationOfEstrogenReceptorBinding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","estrogen","receptor","binding",",","interacting","selectively","with","a","an","estrogen","receptor","."),4170630). assertion_content_comment('tOboGo_RegulationOfEstrogenReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","activity","of","an","estrogen","receptor","signaling","pathway","."),4065594). assertion_content_comment('tOboGo_RegulationOfEthyleneBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","ethylene","biosynthetic","process","."),4031065). assertion_content_comment('tOboGo_RegulationOfEthyleneMediatedSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ethylene","(","ethene",")","mediated","signaling","."),4032999). assertion_content_comment('tOboGo_RegulationOfEukaryoticCellSurfaceBinding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","eukaryotic","cell","surface","binding","."),4171932). assertion_content_comment('tOboGo_RegulationOfExcitatoryPostsynapticMembranePotentialInvolvedInSkeletalMuscleContraction',s("Any","process",",","involved","in","skeletal","muscle","contraction",",","that","modulates","the","establishment","or","extent","of","the","excitatory","postsynaptic","potential","(","EPSP",")","Excitatory","postsynaptic","potential","(","EPSP",")","is","a","temporay","increase","in","postsynaptic","potential","due","to","the","flow","of","positively","charged","ions","into","the","postsynaptic","cell",".","The","flow","of","ions","that","causes","an","EPSP","is","an","excitatory","postsynaptic","current","(","EPSC",")","and","makes","it","easier","for","the","neuron","to","fire","an","action","potential","."),4038734). assertion_content_comment('tOboGo_RegulationOfExcitatoryPostsynapticMembranePotential',s("Any","process","that","modulates","the","establishment","or","extent","of","the","excitatory","postsynaptic","potential","(","EPSP",")","which","is","a","temporary","increase","in","postsynaptic","potential","due","to","the","flow","of","positively","charged","ions","into","the","postsynaptic","cell",".","The","flow","of","ions","that","causes","an","EPSP","is","an","excitatory","postsynaptic","current","(","EPSC",")","and","makes","it","easier","for","the","neuron","to","fire","an","action","potential","."),4038730). assertion_content_comment('tOboGo_RegulationOfExcretion',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","excretion",",","the","elimination","by","an","organism","of","the","waste","products","that","arise","as","a","result","of","metabolic","activity","."),4081073). assertion_content_comment('tOboGo_RegulationOfExitFromMitosis',s("Any","process","involved","in","the","progression","from","anaphase/telophase","to","G1","that","is","associated","with","a","conversion","from","high","to","low","mitotic","CDK","activity","."),3980370). assertion_content_comment('tOboGo_RegulationOfExocystAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","exocyst","assembly","."),3988830). assertion_content_comment('tOboGo_RegulationOfExocystLocalization',s("Any","process","that","modulates","the","localization","of","exocysts",".","An","exocyst","is","a","protein","complex","peripherally","associated","with","the","plasma","membrane","that","determines","where","vesicles","dock","and","fuse","."),4108567). assertion_content_comment('tOboGo_RegulationOfExocytosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","exocytosis","."),3988805). assertion_content_comment('tOboGo_RegulationOfExogen',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","exogen",",","the","shedding","phase","of","the","hair","cycle","."),4122452). assertion_content_comment('tOboGo_RegulationOfExtentOfHeterochromatinFormation',s("Any","process","that","modulates","the","extent","or","location","of","heterochromatin","formation","."),4321487). assertion_content_comment('tOboGo_RegulationOfExtracellularMatrixConstituentSecretion',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","controlled","release","of","molecules","that","form","the","extracellular","matrix",",","including","carbohydrates","and","glycoproteins","by","a","cell","or","a","group","of","cells","."),4006391). assertion_content_comment('tOboGo_RegulationOfExtracellularMatrixDisassembly',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","extracellular","matrix","disassembly",".","Extracellular","matrix","disassembly","is","a","process","that","results","in","the","breakdown","of","the","extracellular","matrix","."),4026917). assertion_content_comment('tOboGo_RegulationOfExtraocularSkeletalMuscleDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","extraocular","skeletal","muscle","development",".","Extraocular","skeletal","muscle","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","extraocular","skeletal","muscle","over","time",",","from","its","formation","to","the","mature","structure",".","The","extraocular","muscle","is","derived","from","cranial","mesoderm","and","controls","eye","movements",".","The","muscle","begins","its","development","with","the","differentiation","of","the","muscle","cells","and","ends","with","the","mature","muscle","."),4040304). assertion_content_comment('tOboGo_RegulationOfExtrathymicTCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","extrathymic","T","cell","differentiation","."),4066098). assertion_content_comment('tOboGo_RegulationOfEyePhotoreceptorCellDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","eye","photoreceptor","development","."),4078745). assertion_content_comment('tOboGo_RegulationOfEyePigmentation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","the","eye","of","an","organism","."),4104169). assertion_content_comment('tOboGo_RegulationOfFasLBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","FasL","."),4086166). assertion_content_comment('tOboGo_RegulationOfFatCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","adipocyte","differentiation","."),4088321). assertion_content_comment('tOboGo_RegulationOfFatCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fat","cell","proliferation","."),4136644). assertion_content_comment('tOboGo_RegulationOfFattyAcidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","fatty","acids",",","any","of","the","aliphatic","monocarboxylic","acids","that","can","be","liberated","by","hydrolysis","from","naturally","occurring","fats","and","oils","."),4058474). assertion_content_comment('tOboGo_RegulationOfFattyAcidMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","fatty","acids","."),4044968). assertion_content_comment('tOboGo_RegulationOfFattyAcidOxidation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fatty","acid","oxidation","."),4057967). assertion_content_comment('tOboGo_RegulationOfFattyAcidTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fatty","acid","transport","."),4024623). assertion_content_comment('tOboGo_RegulationOfFcReceptorMediatedStimulatorySignalingPathway',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","Fc","receptor","mediated","stimulatory","signaling","pathway",".","The","Fc","receptor","mediated","stimulatory","signaling","pathway","is","a","series","of","molecular","signals","generated","as","a","consequence","of","a","the","binding","of","the","Fc","portion","of","an","immunoglobulin","by","an","Fc","receptor","capable","of","activating","or","perpetuating","an","immune","response",".","The","Fc","portion","of","an","immunoglobulin","is","its","C-terminal","constant","region","."),4115011). assertion_content_comment('tOboGo_RegulationOfFeedingBehavior',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","behavior","associated","with","the","intake","of","food","."),4094178). assertion_content_comment('tOboGo_RegulationOfFemaleGonadDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","female","gonad","development","."),4088177). assertion_content_comment('tOboGo_RegulationOfFemalePigmentation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","females","."),4104366). assertion_content_comment('tOboGo_RegulationOfFemaleReceptivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","willingness","or","readiness","of","a","female","to","receive","male","advances","."),4235014). assertion_content_comment('tOboGo_RegulationOfFermentation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fermentation",",","the","anaerobic","enzymatic","conversion","of","organic","compounds",",","especially","carbohydrates",",","to","other","compounds",",","especially","to","ethyl","alcohol",",","resulting","in","energy","in","the","form","of","adenosine","triphosphate","(","ATP",")"),4096327). assertion_content_comment('tOboGo_RegulationOfFerrochelataseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ferrochelatase","activity",";","catalysis","of","the","reaction",":","protoporphyrin","+","Fe2","+","=","protoheme","+","2","H","+"),4336719). assertion_content_comment('tOboGo_RegulationOfFertilization',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","fertilization",".","Fertilization","is","the","union","of","gametes","of","opposite","sexes","during","the","process","of","sexual","reproduction","to","form","a","zygote",".","It","involves","the","fusion","of","the","gametic","nuclei","(","karyogamy",")","and","cytoplasm","(","plasmogamy",")"),4147687). assertion_content_comment('tOboGo_RegulationOfFeverGenerationByRegulationOfProstaglandinBiosynthesis',s("Any","process","that","modulates","the","rate","or","extent","of","fever","generation","via","regulation","of","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","prostaglandin","."),4171133). assertion_content_comment('tOboGo_RegulationOfFeverGenerationByRegulationOfProstaglandinSecretion',s("Any","process","that","modulates","the","rate","or","extent","of","fever","generation","via","regulation","of","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","prostaglandin","from","a","cell","or","group","of","cells","."),4171080). assertion_content_comment('tOboGo_RegulationOfFeverGeneration',s("Any","process","that","modulates","the","rate","or","extent","of","fever","generation","."),4059968). assertion_content_comment('tOboGo_RegulationOfFibrinolysis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fibrinolysis",",","an","ongoing","process","that","solubilizes","fibrin",",","resulting","in","the","removal","of","small","blood","clots","."),4120247). assertion_content_comment('tOboGo_RegulationOfFibroblastApoptosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fibroblast","apoptosis","."),4140233). assertion_content_comment('tOboGo_RegulationOfFibroblastGrowthFactorProduction',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","appearance","of","a","fibroblast","growth","factor","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4151793). assertion_content_comment('tOboGo_RegulationOfFibroblastGrowthFactorReceptorSignalingPathwayInvolvedInNeuralPlateAnteriorPosteriorPatternFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fibroblast","growth","factor","receptor","signaling","pathway","involved","in","neural","plate","anterior/posterior","pattern","formation","."),4139706). assertion_content_comment('tOboGo_RegulationOfFibroblastGrowthFactorReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fibroblast","growth","factor","receptor","signaling","pathway","activity","."),4081799). assertion_content_comment('tOboGo_RegulationOfFibroblastMigration',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","fibroblast","cell","migration",".","Fibroblast","cell","migration","is","accomplished","by","extension","and","retraction","of","a","pseudopodium","."),4024954). assertion_content_comment('tOboGo_RegulationOfFibroblastProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","multiplication","or","reproduction","of","fibroblast","cells","."),4103506). assertion_content_comment('tOboGo_RegulationOfFilamentousGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","process","in","which","a","multicellular","organism","or","a","group","of","unicellular","organisms","grow","in","a","threadlike",",","filamentous","shape","."),4027336). assertion_content_comment('tOboGo_RegulationOfFilopodiumAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","assembly","of","a","filopodium",",","a","thin",",","stiff","protrusion","extended","by","the","leading","edge","of","a","motile","cell","such","as","a","crawling","fibroblast","or","amoeba",",","or","an","axonal","growth","cone","."),4118972). assertion_content_comment('tOboGo_RegulationOfFlagellarCellMotilityByRegulationOfMotorSpeed',s("A","process","that","modulates","flagellar","motility","by","modulating","the","speed","or","direction","of","rotation","of","a","rotary","flagellar","motor",",","mediated","by","interactions","between","the","braking","protein",".","This","process","is","observed","in","prokaryotes",",","where","it","requires","cyclic","di-GMP","binding","to","the","brake","protein","."),4168617). assertion_content_comment('tOboGo_RegulationOfFlagellarCellMotility',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","flagellar","cell","motility","."),4137796). assertion_content_comment('tOboGo_RegulationOfFlagellumAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","of","a","flagellum","."),4052997). assertion_content_comment('tOboGo_RegulationOfFlavonoidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","flavonoids","."),4033133). assertion_content_comment('tOboGo_RegulationOfFlocculation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","non-sexual","aggregation","of","single-celled","organisms","."),4116168). assertion_content_comment('tOboGo_RegulationOfFloralMeristemGrowth',s("Any","process","involved","in","maintaining","the","size","and","shape","of","a","floral","meristem","."),4032569). assertion_content_comment('tOboGo_RegulationOfFloralOrganAbscissionBySignalTransduction',s("The","cascade","of","processes","by","which","a","signal","interacts","with","a","receptor",",","causing","a","change","in","the","level","or","activity","of","a","second","messenger","or","other","downstream","target",",","and","ultimately","modulating","the","rate",",","or","extent","of","floral","organ","abscission","."),4156460). assertion_content_comment('tOboGo_RegulationOfFloralOrganAbscission',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","floral","organ","abscission",",","the","controlled","shedding","of","floral","organs","."),4113892). assertion_content_comment('tOboGo_RegulationOfFlowerDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","flower","development","."),4021286). assertion_content_comment('tOboGo_RegulationOfFocalAdhesionAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","focal","adhesion","formation",",","the","establishment","and","maturation","of","focal","adhesions","."),4122379). assertion_content_comment('tOboGo_RegulationOfFollicleCellMicrovillusLength',s("A","process","that","modulates","the","length","of","a","microvillus","on","a","follicle","cell","."),4331411). assertion_content_comment('tOboGo_RegulationOfFollicleCellMicrovillusOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","microvillus","on","a","follicle","cell","."),4067393). assertion_content_comment('tOboGo_RegulationOfFormationBySymbiontOfHaustoriumForNutrientAcquisitionFromHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","haustorium","formation","for","nutrient","acquisition","from","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146927). assertion_content_comment('tOboGo_RegulationOfForwardLocomotion',s("Any","process","that","modulates","the","speed",",","mechanical","force",",","or","rhythm","of","the","anterior","movement","of","an","organism","."),4094318). assertion_content_comment('tOboGo_RegulationOfFractalkineBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","fractalkine",",","a","chemokine","involved","in","the","control","of","the","key","regulatory","mechanisms","of","cell","trafficking","at","sites","of","inflammation","."),4101174). assertion_content_comment('tOboGo_RegulationOfFractalkineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","fractalkine","production","."),4066957). assertion_content_comment('tOboGo_RegulationOfFruitingBodyDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fruiting","body","development","."),4059612). assertion_content_comment('tOboGo_RegulationOfFucoseCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","fucose","."),4096011). assertion_content_comment('tOboGo_RegulationOfFusionOfSpermToEggPlasmaMembrane',s("Any","process","that","modulates","the","binding","and","fusion","of","a","sperm","to","the","oocyte","plasma","membrane","."),4093904). assertion_content_comment('tOboGo_RegulationOfG0ToG1Transition',s("A","cell","cycle","process","that","modulates","the","rate","or","extent","of","the","transition","from","the","G0","quiescent","state","to","the","G1","phase","."),4137298). assertion_content_comment('tOboGo_RegulationOfG1STransitionOfMitoticCellCycle',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","G1/S","transition","of","mitotic","cell","cycle","."),4060382). assertion_content_comment('tOboGo_RegulationOfG2MTransitionOfMitoticCellCycle',s("Any","process","that","modulates","the","rate","or","extent","of","progression","from","G2","phase","to","M","phase","of","the","mitotic","cell","cycle","."),4031374). assertion_content_comment('tOboGo_RegulationOfG2PhaseOfMitoticCellCycle',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","G2","phase","of","mitotic","cell","cycle","."),4139084). assertion_content_comment('tOboGo_RegulationOfGastricAcidSecretion',s("Any","process","that","modulates","the","rate","frequency","or","extent","of","gastric","secretion",".","Gastric","secretion","is","the","regulated","release","of","gastric","acid","(","hydrochloric","acid",")","by","parietal","or","oxyntic","cells","during","digestion","."),4117698). assertion_content_comment('tOboGo_RegulationOfGastrulation',s("Any","process","that","modulates","the","rate","or","extent","of","gastrulation",".","Gastrulation","is","the","complex","and","coordinated","series","of","cellular","movements","that","occurs","at","the","end","of","cleavage","during","embryonic","development","of","most","animals","."),4029652). assertion_content_comment('tOboGo_RegulationOfGeneExpressionAsAConsequenceOfTCellSignalTransmission',s("OBSOLETE",".","Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gene","expression","as","a","consequence","of","a","process","in","which","a","T","cell","signal","is","released","and/or","conveyed","from","one","location","to","another","."),4347025). assertion_content_comment('tOboGo_RegulationOfGeneExpressionByGeneticImprinting',s("Heritable","alterations","in","the","activity","of","a","gene","that","depend","on","whether","it","passed","through","the","paternal","or","the","maternal","germline",",","but","that","are","not","encoded","by","DNA","itself","."),4156352). assertion_content_comment('tOboGo_RegulationOfGeneExpressionEpigenetic',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gene","expression",";","the","process","is","mitotically","or","meiotically","heritable",",","or","is","stably","self-propagated","in","the","cytoplasm","of","a","resting","cell",",","and","does","not","entail","a","change","in","DNA","sequence","."),4009283). assertion_content_comment('tOboGo_RegulationOfGeneExpression',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gene","expression",".","Gene","expression","is","the","process","in","which","a","gene","'","s","coding","sequence","is","converted","into","a","mature","gene","product","or","products","(","proteins","or","RNA",")","This","includes","the","production","of","an","RNA","transcript","as","well","as","any","processing","to","produce","a","mature","RNA","product","or","an","mRNA","(","for","protein-coding","genes",")","and","the","translation","of","that","mRNA","into","protein",".","Some","protein","processing","events","may","be","included","when","they","are","required","to","form","an","active","form","of","a","product","from","an","inactive","precursor","form","."),3970851). assertion_content_comment('tOboGo_RegulationOfGenerationOfPrecursorMetabolitesAndEnergy',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","precursor","metabolites",",","substances","from","which","energy","is","derived",",","and","the","processes","involved","in","the","liberation","of","energy","from","these","substances","."),3989698). assertion_content_comment('tOboGo_RegulationOfGeneSilencingByMiRNA',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","downregulation","of","gene","expression","through","the","action","of","microRNAs","(","miRNAs",")",",","endogenous","21-24","nucleotide","small","RNAs","processed","from","stem-loop","RNA","precursors","(","pre-miRNAs",")","Once","incorporated","into","a","RNA-induced","silencing","complex","(","RISC",")",",","miRNAs","can","downregulate","gene","expression","by","either","of","two","posttranscriptional","mechanisms",":","mRNA","cleavage","or","translational","repression","."),4112987). assertion_content_comment('tOboGo_RegulationOfGeneSilencingByRNA',s("Any","process","that","regulates","the","rate",",","frequency",",","or","extent","of","gene","silencing","by","RNA",".","Gene","silencing","by","RNA","is","the","process","in","which","RNA","molecules","inactivate","expression","of","target","genes","."),4035049). assertion_content_comment('tOboGo_RegulationOfGeneSilencing',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","gene","silencing",",","the","transcriptional","or","post-transcriptional","process","carried","out","at","the","cellular","level","that","results","in","long-term","gene","inactivation","."),4035034). assertion_content_comment('tOboGo_RegulationOfGerminalCenterFormation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","germinal","center","formation","."),3995655). assertion_content_comment('tOboGo_RegulationOfGibberellicAcidMediatedSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gibberellic","acid","mediated","signaling","."),4033283). assertion_content_comment('tOboGo_RegulationOfGibberellinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","gibberellins","."),4030924). assertion_content_comment('tOboGo_RegulationOfGlialCellApoptosis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","glial","cell","apoptosis","."),4075170). assertion_content_comment('tOboGo_RegulationOfGlialCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glia","cell","differentiation","."),4036237). assertion_content_comment('tOboGo_RegulationOfGlialCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glial","cell","proliferation","."),4028617). assertion_content_comment('tOboGo_RegulationOfGliogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gliogenesis",",","the","formation","of","mature","glia","."),4028614). assertion_content_comment('tOboGo_RegulationOfGlomerularMesangialCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glomerular","mesangial","cell","proliferation","."),4122743). assertion_content_comment('tOboGo_RegulationOfGlomerulusDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","glomerulus","development",",","the","progression","of","the","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney","."),4122740). assertion_content_comment('tOboGo_RegulationOfGlucagonSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","glucagon","."),4133010). assertion_content_comment('tOboGo_RegulationOfGlucanBiosyntheticProcess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","glucan","biosynthesis",".","Glucan","biosynthetic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucans",",","polysaccharides","consisting","only","of","glucose","residues","."),4009157). assertion_content_comment('tOboGo_RegulationOfGlucocorticoidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucocorticoids","."),4057542). assertion_content_comment('tOboGo_RegulationOfGlucocorticoidCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucocorticoids","."),4057465). assertion_content_comment('tOboGo_RegulationOfGlucocorticoidMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","glucocorticoids","."),4057440). assertion_content_comment('tOboGo_RegulationOfGlucocorticoidReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glucocorticoid","receptor","signaling","pathway","."),4139650). assertion_content_comment('tOboGo_RegulationOfGlucokinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glucokinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","glucose","molecule","."),4347943). assertion_content_comment('tOboGo_RegulationOfGluconateTransmembraneTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","gluconate","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083092). assertion_content_comment('tOboGo_RegulationOfGluconateTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","gluconate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4064692). assertion_content_comment('tOboGo_RegulationOfGluconeogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gluconeogenesis",",","the","formation","of","glucose","from","noncarbohydrate","precursors",",","such","as","pyruvate",",","amino","acids","and","glycerol","."),4010504). assertion_content_comment('tOboGo_RegulationOfGlucoseImport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","import","of","the","hexose","monosaccharide","glucose","into","a","cell","or","organelle","."),4098139). assertion_content_comment('tOboGo_RegulationOfGlucoseMetabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","glucose","metabolism",".","Glucose","metabolic","processes","are","the","chemical","reactions","and","pathways","involving","glucose",",","the","aldohexose","gluco-hexose","."),4008986). assertion_content_comment('tOboGo_RegulationOfGlucoseTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glucose","transport",".","Glucose","transport","is","the","directed","movement","of","the","hexose","monosaccharide","glucose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4036556). assertion_content_comment('tOboGo_RegulationOfGlucosinolateBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosinolates",",","substituted","thioglucosides","found","in","rapeseed","products","and","related","cruciferae","."),4029136). assertion_content_comment('tOboGo_RegulationOfGlucosylceramideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosylceramide","."),4098392). assertion_content_comment('tOboGo_RegulationOfGlutamateMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glutamate","metabolic","process","."),4141186). assertion_content_comment('tOboGo_RegulationOfGlutamateSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","controlled","release","of","glutamate","."),4039651). assertion_content_comment('tOboGo_RegulationOfGlutamateUptakeInvolvedInTransmissionOfNerveImpulse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","L-glutamate","into","a","neuron","or","glial","cell","."),4120526). assertion_content_comment('tOboGo_RegulationOfGlutamineFamilyAminoAcidMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","amino","acids","of","the","glutamine","family",",","comprising","arginine",",","glutamate",",","glutamine","and","proline","."),3979073). assertion_content_comment('tOboGo_RegulationOfGlutamineTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glutamine","transport","."),4145820). assertion_content_comment('tOboGo_RegulationOfGlycerolTransport',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","directed","movement","of","glycerol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4151280). assertion_content_comment('tOboGo_RegulationOfGlycogenBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycogen","."),4009161). assertion_content_comment('tOboGo_RegulationOfGlycogenCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycogen","."),4009008). assertion_content_comment('tOboGo_RegulationOfGlycogenMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","glycogen","."),4009004). assertion_content_comment('tOboGo_RegulationOfGlycogenStarchSynthaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glycogen","(","starch",")","synthase","activity","."),4171961). assertion_content_comment('tOboGo_RegulationOfGlycolysisByNegativeRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glycolysis","by","stopping",",","preventing",",","or","reducing","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4159020). assertion_content_comment('tOboGo_RegulationOfGlycolysisByPositiveRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glycolysis","by","activating","or","increasing","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4158999). assertion_content_comment('tOboGo_RegulationOfGlycolysisByRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glycolysis","by","modulating","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4158997). assertion_content_comment('tOboGo_RegulationOfGlycolysis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","glycolysis","."),4010446). assertion_content_comment('tOboGo_RegulationOfGlycoproteinBiosyntheticProcess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycoproteins",",","any","protein","that","contains","covalently","bound","glycose","(","i.e",".","monosaccharide",")","residues",";","the","glycose","occurs","most","commonly","as","oligosaccharide","or","fairly","small","polysaccharide","but","occasionally","as","monosaccharide","."),4027939). assertion_content_comment('tOboGo_RegulationOfGolgiInheritance',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","Golgi","inheritance",".","Golgi","inheritance","is","the","partitioning","of","Golgi","apparatus","between","daughter","cells","at","cell","division","."),4149364). assertion_content_comment('tOboGo_RegulationOfGolgiToPlasmaMembraneCFTRProteinTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","transport","of","Cystic","Fibrosis","Transmembrane","conductance","Regulator","(","CFTR",")","protein","from","the","Golgi","to","the","plasma","membrane","."),4093868). assertion_content_comment('tOboGo_RegulationOfGolgiToPlasmaMembraneProteinTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","transport","of","proteins","from","the","Golgi","to","the","plasma","membrane","."),4093848). assertion_content_comment('tOboGo_RegulationOfGolgiVesicleFusionToTargetMembrane',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","Golgi","vesicle","fusion","to","target","membrane","."),4103278). assertion_content_comment('tOboGo_RegulationOfGonadotropinSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","gonadotropin","."),4054768). assertion_content_comment('tOboGo_RegulationOfGranulocyteChemotaxis',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","granulocyte","chemotaxis",".","Granulocyte","chemotaxis","is","the","movement","of","a","granulocyte","in","response","to","an","external","stimulus","."),4025013). assertion_content_comment('tOboGo_RegulationOfGranulocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","granulocyte","differentiation","."),4061726). assertion_content_comment('tOboGo_RegulationOfGranulomaFormation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","granuloma","formation","."),3995626). assertion_content_comment('tOboGo_RegulationOfGranzymeAProduction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","granzyme","A","production","."),4144873). assertion_content_comment('tOboGo_RegulationOfGranzymeBProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","granzyme","B","."),4129226). assertion_content_comment('tOboGo_RegulationOfGrowthHormoneReceptorSignalingPathway',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","growth","hormone","receptor","signaling","pathway",".","The","growth","hormone","receptor","signaling","pathway","is","the","series","of","molecular","signals","generated","as","a","consequence","of","growth","hormone","receptor","binding","to","its","physiological","ligand","."),4117384). assertion_content_comment('tOboGo_RegulationOfGrowthHormoneSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","growth","hormone","from","a","cell","or","group","of","cells","."),4108998). assertion_content_comment('tOboGo_RegulationOfGrowthOfSymbiontInHost',s("Any","process","in","which","the","symbiont","regulates","the","increase","in","its","size","or","mass","within","the","cells","or","tissues","of","the","host","organism",".","This","may","(","but","not","necessarily",")","include","a","filamentous","growth","form",",","and","also","can","include","secretion","of","proteases","and","lipases","to","break","down",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4097804). assertion_content_comment('tOboGo_RegulationOfGrowthOfUnicellularOrganismAsAThreadOfAttachedCells',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","process","in","which","cells","remain","attached","after","division","and","form","thread-like","filaments","that","may","penetrate","into","a","solid","growth","medium","."),4132662). assertion_content_comment('tOboGo_RegulationOfGrowthOrDevelopmentOfSymbiontInHost',s("OBSOLETE",".","Any","process","by","which","the","symbiont","regulates","the","increase","in","its","size","or","mass",",","or","its","progression","from","an","initial","condition","to","a","later","condition",",","within","the","cells","or","tissues","of","the","host","organism",".","This","may","(","but","not","necessarily",")","include","a","filamentous","growth","form",",","and","also","can","include","secretion","of","proteases","and","lipases","to","break","down",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","the","symbiotic","interaction","."),4341389). assertion_content_comment('tOboGo_RegulationOfGrowthPlateCartilageChondrocyteProliferation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","multiplication","or","reproduction","of","chondrocytes","in","a","growing","endochondral","bone",",","resulting","in","the","expansion","of","a","cell","population","."),4004413). assertion_content_comment('tOboGo_RegulationOfGrowthRate',s("Any","process","that","modulates","the","rate","of","growth","of","all","or","part","of","an","organism","."),4234350). assertion_content_comment('tOboGo_RegulationOfGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","growth","of","all","or","part","of","an","organism","so","that","it","occurs","at","its","proper","speed",",","either","globally","or","in","a","specific","part","of","the","organism","'","s","development","."),3980820). assertion_content_comment('tOboGo_RegulationOfGTPaseActivity',s("Any","process","that","modulates","the","rate","of","GTP","hydrolysis","by","a","GTPase","."),4056254). assertion_content_comment('tOboGo_RegulationOfGTPCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","GTP",",","guanosine","triphosphate","."),4056248). assertion_content_comment('tOboGo_RegulationOfGTPCyclohydrolaseIActivity',s("Any","process","that","modulates","the","activity","of","the","enzyme","GTP","cyclohydrolase","I","."),4317657). assertion_content_comment('tOboGo_RegulationOfGuanylateCyclaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","guanylate","cyclase","activity","."),4320178). assertion_content_comment('tOboGo_RegulationOfHairCycleByBMPSignalingPathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","modulates","the","rate",",","frequency","or","extent","of","the","hair","cycle","."),4156894). assertion_content_comment('tOboGo_RegulationOfHairCycleByCanonicalWntReceptorSignalingPathway',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","modulates","the","rate",",","frequency","or","extent","of","the","hair","cycle","."),4156905). assertion_content_comment('tOboGo_RegulationOfHairCycle',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","cyclical","phases","of","growth","(","anagen",")",",","regression","(","catagen",")",",","quiescence","(","telogen",")",",","and","shedding","(","exogen",")","in","the","life","of","a","hair","."),4077841). assertion_content_comment('tOboGo_RegulationOfHairFollicleCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hair","follicle","cell","proliferation","."),4128340). assertion_content_comment('tOboGo_RegulationOfHairFollicleDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hair","follicle","development","."),4105181). assertion_content_comment('tOboGo_RegulationOfHairFollicleMaturation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hair","follicle","maturation","."),4105184). assertion_content_comment('tOboGo_RegulationOfHairFolliclePlacodeFormation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","hair","follicle","placode","formation",",","the","developmental","process","in","which","a","hair","placode","forms",".","An","hair","follicle","placode","is","a","thickening","of","the","ectoderm","that","will","give","rise","to","the","hair","follicle","bud","."),4135780). assertion_content_comment('tOboGo_RegulationOfHaustoriumMotherCellFormationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","haustorium","mother","cell","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146678). assertion_content_comment('tOboGo_RegulationOfHeartContraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","heart","contraction",".","Heart","contraction","is","the","process","in","which","the","heart","decreases","in","volume","in","a","characteristic","way","to","propel","blood","through","the","body","."),3987495). assertion_content_comment('tOboGo_RegulationOfHeartGrowth',s("Any","process","that","modulates","the","rate","or","extent","of","heart","growth",".","Heart","growth","is","the","increase","in","size","or","mass","of","the","heart","."),4107774). assertion_content_comment('tOboGo_RegulationOfHeartInductionByRegulationOfCanonicalWntReceptorSignalingPathway',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","canonical","Wnt","receptor","signaling","pathway","that","regulates","heart","induction",".","Canonical","Wnt","receptor","signaling","pathway","involved","in","heart","induction","is","the","series","of","molecular","signals","initiated","by","binding","of","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","relaying","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","."),4150151). assertion_content_comment('tOboGo_RegulationOfHeartInduction',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","heart","induction",".","Heart","induction","is","the","close","range","interaction","between","mesoderm","and","endoderm","or","ectoderm","that","causes","cells","to","change","their","fates","and","specify","the","development","of","the","heart","."),4003511). assertion_content_comment('tOboGo_RegulationOfHeartRateByChemicalSignal',s("The","regulation","of","the","rate","of","heart","contraction","mediated","by","chemical","signaling",",","hormonal",",","autocrine","or","paracrine","."),4003815). assertion_content_comment('tOboGo_RegulationOfHeartRateByHormone',s("The","process","in","which","the","hormones","modulates","the","rate","of","heart","muscle","contraction",".","A","hormone","is","one","of","a","group","of","substances","formed","in","very","small","amounts","in","one","specialized","organ","or","group","of","cells","and","carried","(","sometimes","in","the","bloodstream",")","to","another","organ","or","group","of","cells",",","in","the","same","organism",",","upon","which","they","have","a","specific","regulatory","action","."),4194000). assertion_content_comment('tOboGo_RegulationOfHeartRate',s("Any","process","that","modulates","the","frequency","or","rate","of","heart","contraction","."),3987499). assertion_content_comment('tOboGo_RegulationOfHeatDissipation',s("Any","process","that","modulates","the","rate","or","extent","of","heat","dissipation","."),4059760). assertion_content_comment('tOboGo_RegulationOfHeatGeneration',s("Any","process","that","modulates","the","rate","or","extent","of","heat","generation","."),4059813). assertion_content_comment('tOboGo_RegulationOfHelicaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","helicase","activity","."),4287165). assertion_content_comment('tOboGo_RegulationOfHematopoieticStemCellMigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hematopoietic","stem","cell","migration","."),4145410). assertion_content_comment('tOboGo_RegulationOfHemeBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","heme","."),4131364). assertion_content_comment('tOboGo_RegulationOfHemocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hemocyte","differentiation","."),4072190). assertion_content_comment('tOboGo_RegulationOfHemocyteProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hemocyte","proliferation",".","Hemocytes","are","blood","cells","associated","with","a","hemocoel","(","the","cavity","containing","most","of","the","major","organs","of","the","arthropod","body",")","which","are","involved","in","defense","and","clotting","of","hemolymph",",","but","not","involved","in","transport","of","oxygen",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4072128). assertion_content_comment('tOboGo_RegulationOfHemoglobinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hemoglobin",",","an","oxygen","carrying",",","conjugated","protein","containing","four","heme","groups","and","globin","."),4099819). assertion_content_comment('tOboGo_RegulationOfHeparanSulfateProteoglycanBiosyntheticProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","heparan","sulfate","proteoglycan","biosynthesis",".","Heparan","sulfate","proteoglycan","biosynthetic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","heparan","sulfate","proteoglycan",",","a","glycosaminoglycan","with","repeat","unit","consisting","of","alternating","(","alpha1-","&","gt",";","4",")","-linked","hexuronic","acid","and","glucosamine","residues","."),4038267). assertion_content_comment('tOboGo_RegulationOfHepaticStellateCellActivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hepatic","stellate","cell","activation","."),4145889). assertion_content_comment('tOboGo_RegulationOfHepatocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hepatocyte","differentiation","."),4136904). assertion_content_comment('tOboGo_RegulationOfHepatocyteGrowthFactorBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hepatocyte","growth","factor","."),4103435). assertion_content_comment('tOboGo_RegulationOfHepatocyteGrowthFactorProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","hepatocyte","growth","factor","production","."),4067007). assertion_content_comment('tOboGo_RegulationOfHepatocyteProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hepatocyte","proliferation","."),4143343). assertion_content_comment('tOboGo_RegulationOfHeterochromatinFormation',s("Any","process","that","modulates","the","frequency",",","rate",",","extent","or","location","of","heterochromatin","formation","."),4058183). assertion_content_comment('tOboGo_RegulationOfHindgutContraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","contraction","of","the","hindgut",",","the","posterior","part","of","the","alimentary","canal",",","including","the","rectum",",","and","the","large","intestine","."),4092849). assertion_content_comment('tOboGo_RegulationOfHippoSignalingCascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hippo","signaling","."),4071349). assertion_content_comment('tOboGo_RegulationOfHistamineUptake',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","the","neurotransmitter","histamine","into","a","cell","."),4121705). assertion_content_comment('tOboGo_RegulationOfHistolysis',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","breakdown","of","tissues",";","usually",",","if","not","always",",","accompanied","by","cell","death","."),4026739). assertion_content_comment('tOboGo_RegulationOfHistoneAcetylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","addition","of","an","acetyl","group","to","a","histone","protein","."),4072880). assertion_content_comment('tOboGo_RegulationOfHistoneDeacetylationAtCentromere',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","removal","of","acetyl","groups","from","histones","in","centromeric","DNA","."),4062808). assertion_content_comment('tOboGo_RegulationOfHistoneDeacetylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","removal","of","acetyl","groups","from","histones","."),4062776). assertion_content_comment('tOboGo_RegulationOfHistoneH4Acetylation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","histone","H4","acetylation",",","the","modification","of","histone","H4","by","the","addition","of","an","acetyl","group","."),4143553). assertion_content_comment('tOboGo_RegulationOfHistoneMethylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","covalent","addition","of","methyl","groups","to","histones","."),3975638). assertion_content_comment('tOboGo_RegulationOfHistoneModification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","covalent","alteration","of","a","histone","."),3975635). assertion_content_comment('tOboGo_RegulationOfHistonePhosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","addition","of","one","or","more","phosphate","groups","to","a","histone","protein","."),4065981). assertion_content_comment('tOboGo_RegulationOfHistoneUbiquitination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","addition","of","a","ubiquitin","group","to","a","histone","protein","."),4065484). assertion_content_comment('tOboGo_RegulationOfHomeostaticProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","homeostatic","process","."),3999601). assertion_content_comment('tOboGo_RegulationOfHomocysteineMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","homocysteine",",","the","amino","acid","alpha-amino-gamma-mercaptobutanoic","acid","."),4101432). assertion_content_comment('tOboGo_RegulationOfHomologousChromosomeSegregation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","homologous","chromosome","segregation",",","the","cell","cycle","process","in","which","replicated","homologous","chromosomes","are","organized","and","then","physically","separated","and","apportioned","to","two","sets","during","the","first","division","of","the","meiotic","cell","cycle",".","Each","replicated","chromosome",",","composed","of","two","sister","chromatids",",","aligns","at","the","cell","equator",",","paired","with","its","homologous","partner",";","this","pairing","off",",","referred","to","as","synapsis",",","permits","genetic","recombination",".","One","homolog","(","both","sister","chromatids",")","of","each","morphologic","type","goes","into","each","of","the","resulting","chromosome","sets","."),4111753). assertion_content_comment('tOboGo_RegulationOfHormoneBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","hormones","."),4015687). assertion_content_comment('tOboGo_RegulationOfHormoneLevels',s("Any","process","that","modulates","the","levels","of","hormone","within","an","organism","or","a","tissue",".","A","hormone","is","any","substance","formed","in","very","small","amounts","in","one","specialized","organ","or","group","of","cells","and","carried","(","sometimes","in","the","bloodstream",")","to","another","organ","or","group","of","cells","in","the","same","organism",",","upon","which","it","has","a","specific","regulatory","action","."),3991665). assertion_content_comment('tOboGo_RegulationOfHormoneMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","any","hormone","."),4015657). assertion_content_comment('tOboGo_RegulationOfHormoneSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","hormone","from","a","cell","or","group","of","cells","."),4015417). assertion_content_comment('tOboGo_RegulationOfHulleCellDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","Hulle","cell","development",",","a","process","that","leads","to","the","formation","of","Hulle","cells",".","Hulle","cells","are","specialized","multinucleate","cells","that","originate","from","a","nest-like","aggregation","of","hyphae","during","sexual","development","and","serve","as","nurse","cells","to","the","developing","cleistothecium",",","or","fruiting","body","."),4132467). assertion_content_comment('tOboGo_RegulationOfHumoralImmuneResponseMediatedByCirculatingImmunoglobulin',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","humoral","immune","response","mediated","by","circulating","immunoglobulin","."),3999755). assertion_content_comment('tOboGo_RegulationOfHumoralImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","humoral","immune","response","."),3986152). assertion_content_comment('tOboGo_RegulationOfHydrogenPeroxideBiosyntheticProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","hydrogen","peroxide","biosynthesis",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hydrogen","peroxide","(","H2O2",")",",","a","potentially","harmful","byproduct","of","aerobic","cellular","respiration","which","can","cause","damage","to","DNA","."),4024444). assertion_content_comment('tOboGo_RegulationOfHydrogenPeroxideCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hydrogen","peroxide","catabolic","process","."),4139955). assertion_content_comment('tOboGo_RegulationOfHydrogenPeroxideMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","hydrogen","peroxide","."),4024274). assertion_content_comment('tOboGo_RegulationOfHydrolaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","hydrolase","activity",",","the","catalysis","of","the","hydrolysis","of","various","bonds",",","e.g",".","C-O",",","C-N",",","C-C",",","phosphoric","anhydride","bonds",",","etc",".","Hydrolase","is","the","systematic","name","for","any","enzyme","of","EC","class","3","."),4011517). assertion_content_comment('tOboGo_RegulationOfHypersensitivity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","hypersensitivity","."),3983247). assertion_content_comment('tOboGo_RegulationOfHyphopodiumFormationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","hyphopodium","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146632). assertion_content_comment('tOboGo_RegulationOfHypoxanthineTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","hypoxanthine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083502). assertion_content_comment('tOboGo_RegulationOfIcosanoidSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","controlled","release","of","an","icosanoid","from","a","cell","or","group","of","cells","."),4054669). assertion_content_comment('tOboGo_RegulationOfImaginalDiscGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","growth","of","the","imaginal","disc","."),4087949). assertion_content_comment('tOboGo_RegulationOfImmatureTCellProliferationInThymus',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","immature","T","cell","proliferation","in","the","thymus","."),4066135). assertion_content_comment('tOboGo_RegulationOfImmatureTCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","immature","T","cell","proliferation","."),4066123). assertion_content_comment('tOboGo_RegulationOfImmuneComplexClearanceByMonocytesAndMacrophages',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","process","of","immune","complex","clearance","by","monocytes","or","macrophages","."),4151866). assertion_content_comment('tOboGo_RegulationOfImmuneEffectorProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","immune","effector","process","."),3983272). assertion_content_comment('tOboGo_RegulationOfImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","immune","response",",","the","immunological","reaction","of","an","organism","to","an","immunogenic","stimulus","."),3983238). assertion_content_comment('tOboGo_RegulationOfImmuneResponseToTumorCell',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","immune","response","to","tumor","cell","."),4000039). assertion_content_comment('tOboGo_RegulationOfImmuneSystemProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","immune","system","process","."),3983234). assertion_content_comment('tOboGo_RegulationOfImmunoglobulinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","immunoglobulin","biosynthesis","."),3995534). assertion_content_comment('tOboGo_RegulationOfImmunoglobulinMediatedImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","immunoglobulin","mediated","immune","response","."),3983335). assertion_content_comment('tOboGo_RegulationOfImmunoglobulinProductionInMucosalTissue',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","immunoglobulin","production","in","mucosal","tissue","."),4145040). assertion_content_comment('tOboGo_RegulationOfImmunoglobulinProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","immunoglobulin","production","."),3995484). assertion_content_comment('tOboGo_RegulationOfImmunoglobulinSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","immunoglobulins","from","a","cell","or","group","of","cells","."),4119188). assertion_content_comment('tOboGo_RegulationOfImmunologicalSynapseFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","immunological","synapse","formation","."),4144908). assertion_content_comment('tOboGo_RegulationOfInclusionBodyAssembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","inclusion","body","assembly",".","Inclusion","body","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","inclusion","body","."),4150317). assertion_content_comment('tOboGo_RegulationOfInductionOfApoptosisInResponseToChemicalStimulus',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","induction","of","apoptosis","in","response","to","chemical","stimulus","."),4145638). assertion_content_comment('tOboGo_RegulationOfInductionOfConjugationUponNitrogenStarvation',s("Any","process","that","modulates","the","frequency","of","induction","of","conjugation","upon","nitrogen","starvation",",","the","process","in","which","a","cell","initiates","conjugation","with","cellular","fusion","upon","nitrogen","starvation","."),4114216). assertion_content_comment('tOboGo_RegulationOfInfectionCushionFormationOnOrNearHost',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","infection","cushion","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146586). assertion_content_comment('tOboGo_RegulationOfInflammatoryResponseBySphingolipidSignalingPathway',s("A","series","of","molecular","signals","mediated","by","a","sphingolipid","that","modulates","the","rate",",","frequency",",","or","extent","of","the","inflammatory","response","."),4194143). assertion_content_comment('tOboGo_RegulationOfInflammatoryResponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","inflammatory","response",",","the","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents","."),3983206). assertion_content_comment('tOboGo_RegulationOfInflammatoryResponseToAntigenicStimulus',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","inflammatory","response","to","an","antigenic","stimulus","."),3983241). assertion_content_comment('tOboGo_RegulationOfInflorescenceMeristemGrowth',s("Any","process","involved","in","maintaining","the","size","and","shape","of","an","inflorescence","meristem","."),4032181). assertion_content_comment('tOboGo_RegulationOfInhibinSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","inhibin","from","a","cell","or","group","of","cells","."),4056135). assertion_content_comment('tOboGo_RegulationOfInhibitoryPostsynapticMembranePotential',s("Any","process","that","modulates","the","establishment","or","extent","of","the","inhibitory","postsynaptic","potential","(","IPSP",")","which","is","a","temporay","decrease","in","postsynaptic","potential","due","to","the","flow","of","negatively","charged","ions","into","the","postsynaptic","cell",".","The","flow","of","ions","that","causes","an","IPSP","is","an","inhibitory","postsynaptic","current","(","IPSC",")","and","makes","it","more","difficult","for","the","neuron","to","fire","an","action","potential","."),4159465). assertion_content_comment('tOboGo_RegulationOfInitiationOfAcetateCatabolicProcessByAcetate',s("Any","process","that","modulates","the","activation",",","by","acetate",",","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate","."),4086647). assertion_content_comment('tOboGo_RegulationOfInitiationOfMatingProjectionGrowth',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","start","of","mating","projection","formation","by","unicellular","fungi","."),4319798). assertion_content_comment('tOboGo_RegulationOfInitiationOfTCellReceptorSignaling',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","initiation","of","T","cell","receptor","signaling","."),4052370). assertion_content_comment('tOboGo_RegulationOfInnateImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","innate","immune","response",",","the","organism","'","s","first","line","of","defense","against","infection","."),3986268). assertion_content_comment('tOboGo_RegulationOfInosineTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","inosine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083438). assertion_content_comment('tOboGo_RegulationOfInositolPhosphateBiosyntheticProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","inositol","phosphate","biosynthesis",".","Inositol","phosphate","biosynthetic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","inositol","phosphate",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","with","one","or","more","phosphate","groups","attached","."),4034841). assertion_content_comment('tOboGo_RegulationOfInositolTrisphosphateBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","inositol","trisphosphate","."),4063770). assertion_content_comment('tOboGo_RegulationOfInsulinReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","insulin","receptor","signaling","."),4098855). assertion_content_comment('tOboGo_RegulationOfInsulinSecretionInvolvedInCellularResponseToGlucoseStimulus',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","insulin","that","contributes","to","the","response","of","a","cell","to","glucose","."),4081386). assertion_content_comment('tOboGo_RegulationOfInsulinSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","insulin","."),4057073). assertion_content_comment('tOboGo_RegulationOfIntegrinActivation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","integrin","activation","."),4063611). assertion_content_comment('tOboGo_RegulationOfIntegrinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","integrins","."),4086537). assertion_content_comment('tOboGo_RegulationOfIntermediateFilamentDepolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","disassembly","of","intermediate","filaments","by","the","removal","of","monomers","from","a","filament","."),4051386). assertion_content_comment('tOboGo_RegulationOfIntermediateFilamentPolymerizationOrDepolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","assembly","or","disassembly","of","intermediate","filaments","by","the","addition","or","removal","of","monomers","from","a","filament",";","this","usually","occurs","through","the","opposing","action","of","kinases","and","phosphatases","."),4051383). assertion_content_comment('tOboGo_RegulationOfIntermediateFilamentPolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","assembly","of","intermediate","filaments","by","the","addition","of","monomers","to","a","filament","."),4051415). assertion_content_comment('tOboGo_RegulationOfIntermediateMesodermalCellFateDetermination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","intermediate","mesoderm","cell","fate","determination","."),4102117). assertion_content_comment('tOboGo_RegulationOfIntermediateMesodermalCellFateSpecification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","intermediate","mesoderm","cell","fate","specification","."),4102022). assertion_content_comment('tOboGo_RegulationOfInterphaseOfMitoticCellCycle',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","interphase","of","mitotic","cell","cycle","."),4012835). assertion_content_comment('tOboGo_RegulationOfIntestinalCholesterolAbsorption',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","absorption","of","cholesterol","into","the","blood",",","and","the","exclusion","of","other","sterols","from","absorption","."),4048348). assertion_content_comment('tOboGo_RegulationOfIntestinalEpithelialStructureMaintenance',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","intestinal","epithelial","structure","maintenance",",","a","tissue","homeostatic","process","required","for","the","maintenance","of","the","structure","of","the","intestinal","epithelium","."),4110804). assertion_content_comment('tOboGo_RegulationOfIntracellularCholesterolTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","cholesterol","within","cells","."),4056570). assertion_content_comment('tOboGo_RegulationOfIntracellularLipidTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","lipids","within","cells","."),4056529). assertion_content_comment('tOboGo_RegulationOfIntracellularPH',s("Any","process","that","modulates","the","internal","pH","of","a","cell",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4070005). assertion_content_comment('tOboGo_RegulationOfIntracellularProteinKinaseCascade',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","a","series","of","reactions",",","mediated","by","protein","kinases",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),4016592). assertion_content_comment('tOboGo_RegulationOfIntracellularProteinTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","proteins","within","cells","."),4016251). assertion_content_comment('tOboGo_RegulationOfIntracellularSterolTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","sterols","within","cells","."),4056550). assertion_content_comment('tOboGo_RegulationOfIntracellularTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","within","cells","."),4004978). assertion_content_comment('tOboGo_RegulationOfInvasiveGrowthInResponseToGlucoseLimitation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","invasive","growth","in","response","to","glucose","limitation","."),4140760). assertion_content_comment('tOboGo_RegulationOfIonHomeostasis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ion","homeostasis","."),4003117). assertion_content_comment('tOboGo_RegulationOfIonTransmembraneTransporterActivity',s("Any","process","that","modulates","the","activity","of","an","ion","transporter","."),4160420). assertion_content_comment('tOboGo_RegulationOfIonTransmembraneTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","ions","from","one","side","of","a","membrane","to","the","other","."),4073257). assertion_content_comment('tOboGo_RegulationOfIonTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","charged","atoms","or","small","charged","molecules","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990642). assertion_content_comment('tOboGo_RegulationOfIridophoreDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","iridophore","differentiation","."),4099977). assertion_content_comment('tOboGo_RegulationOfIronIonTransmembraneTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","iron","ions","(","Fe",")","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4073337). assertion_content_comment('tOboGo_RegulationOfIronIonTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","iron","ions","(","Fe",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4073302). assertion_content_comment('tOboGo_RegulationOfIsomeraseActivity',s("Any","process","that","modulates","the","activity","of","an","isomerase",".","An","isomerase","catalyzes","the","geometric","or","structural","changes","within","one","molecule",".","Isomerase","is","the","systematic","name","for","any","enzyme","of","EC","class","5","."),4172449). assertion_content_comment('tOboGo_RegulationOfIsoprenoidMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","isoprenoids","."),4015645). assertion_content_comment('tOboGo_RegulationOfIsotypeSwitching',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","isotype","switching","."),4086090). assertion_content_comment('tOboGo_RegulationOfIsotypeSwitchingToIgAIsotypes',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgA","isotypes","."),4103833). assertion_content_comment('tOboGo_RegulationOfIsotypeSwitchingToIgDIsotypes',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgD","isotypes","."),4103601). assertion_content_comment('tOboGo_RegulationOfIsotypeSwitchingToIgEIsotypes',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgE","isotypes","."),4103799). assertion_content_comment('tOboGo_RegulationOfIsotypeSwitchingToIgGIsotypes',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","isotype","switching","to","IgG","isotypes","."),4103654). assertion_content_comment('tOboGo_RegulationOfJasmonicAcidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","jasmonic","acid","."),4147831). assertion_content_comment('tOboGo_RegulationOfJasmonicAcidMediatedSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","jasmonic","acid","mediated","signaling","pathway","."),4139481). assertion_content_comment('tOboGo_RegulationOfJasmonicAcidMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","jasmonic","acid","."),4147828). assertion_content_comment('tOboGo_RegulationOfJNKCascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","JNK","cascade","."),4016616). assertion_content_comment('tOboGo_RegulationOfJUNKinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","JUN","kinase","activity","."),4016619). assertion_content_comment('tOboGo_RegulationOfJuvenileHormoneBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","juvenile","hormone","."),4015712). assertion_content_comment('tOboGo_RegulationOfJuvenileHormoneCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","juvenile","hormone","."),4092420). assertion_content_comment('tOboGo_RegulationOfJuvenileHormoneMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","juvenile","hormone","."),4015674). assertion_content_comment('tOboGo_RegulationOfJuvenileHormoneSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","juvenile","hormone","secretion","."),4015420). assertion_content_comment('tOboGo_RegulationOfKainateSelectiveGlutamateReceptorActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","kainate","selective","glutamate","receptor","activity","."),4170235). assertion_content_comment('tOboGo_RegulationOfKaryogamy',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","karyogamy",",","the","creation","of","a","single","nucleus","from","multiple","nuclei","as","a","result","of","membrane","fusion","."),4070294). assertion_content_comment('tOboGo_RegulationOfKeratinocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","keratinocyte","differentiation","."),4087249). assertion_content_comment('tOboGo_RegulationOfKeratinocyteMigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","keratinocyte","migration","."),4118846). assertion_content_comment('tOboGo_RegulationOfKeratinocyteProliferation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","keratinocyte","proliferation",".","Keratinocyte","proliferation","is","the","multiplication","or","reproduction","of","keratinocytes",",","resulting","in","the","expansion","of","a","cell","population","."),4036682). assertion_content_comment('tOboGo_RegulationOfKetoneBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","ketone",",","carried","out","by","individual","cells","."),4015863). assertion_content_comment('tOboGo_RegulationOfKetoneCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","ketone",",","carried","out","by","individual","cells","."),4027383). assertion_content_comment('tOboGo_RegulationOfKidneyDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","kidney","development",".","Kidney","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","kidney","over","time",",","from","its","formation","to","the","mature","structure",".","The","kidney","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4006204). assertion_content_comment('tOboGo_RegulationOfKidneySize',s("Any","process","that","modulates","the","size","of","a","kidney","."),4082224). assertion_content_comment('tOboGo_RegulationOfKidneySmoothMuscleCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","kidney","smooth","muscle","cell","differentiation","."),4142845). assertion_content_comment('tOboGo_RegulationOfKillingOfCellsOfOtherOrganism',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","killing","by","an","organism","of","cells","in","another","organism","."),3985870). assertion_content_comment('tOboGo_RegulationOfKinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","substrate","molecule","."),3972507). assertion_content_comment('tOboGo_RegulationOfKinetochoreAssembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","kinetochore","assembly",",","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","kinetochore",",","a","multisubunit","complex","that","is","located","at","the","centromeric","region","of","DNA","and","provides","an","attachment","point","for","the","spindle","microtubules","."),4151641). assertion_content_comment('tOboGo_RegulationOfKininCascade',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","kinin","cascade","."),3992143). assertion_content_comment('tOboGo_RegulationOfLamellipodiumAssembly',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","formation","of","a","lamellipodium",",","a","thin","sheetlike","extension","of","the","surface","of","a","migrating","cell","."),4028498). assertion_content_comment('tOboGo_RegulationOfLamellipodiumMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lamellipodium","morphogenesis","."),4142450). assertion_content_comment('tOboGo_RegulationOfLamellocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lamellocyte","differentiation",".","Lamellocytes","differentiate","massively","in","the","lymph","glands","after","parasitization","and","are","large","flat","cells","devoted","to","encapsulation","of","invaders","too","large","to","be","phagocytosed","by","plasmatocytes","."),4072195). assertion_content_comment('tOboGo_RegulationOfLarvalSalivaryGlandBoundarySpecification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","salivary","gland","determination","in","a","larval","organism","."),4091368). assertion_content_comment('tOboGo_RegulationOfLateralMesodermalCellFateDetermination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lateral","mesoderm","cell","fate","determination","."),4102392). assertion_content_comment('tOboGo_RegulationOfLateralMesodermalCellFateSpecification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lateral","mesoderm","cell","fate","specification","."),4102329). assertion_content_comment('tOboGo_RegulationOfLateralPseudopodiumAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","assembly","of","pseudopodia","from","the","lateral","side","of","the","cell","."),4059486). assertion_content_comment('tOboGo_RegulationOfLateralRootDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lateral","root","development","."),4139492). assertion_content_comment('tOboGo_RegulationOfLateStripeMelanocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","late","stripe","melanocyte","differentiation","."),4099912). assertion_content_comment('tOboGo_RegulationOfLeafDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","leaf","development","."),4139026). assertion_content_comment('tOboGo_RegulationOfLeafFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","leaf","formation","."),4139471). assertion_content_comment('tOboGo_RegulationOfLeafletFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","leaflet","formation","."),4149635). assertion_content_comment('tOboGo_RegulationOfLeucineImport',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","leucine","import",".","Leucine","import","is","the","directed","movement","of","leucine","into","a","cell","or","organelle","."),4115154). assertion_content_comment('tOboGo_RegulationOfLeucophoreDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","leucophore","differentiation","."),4104992). assertion_content_comment('tOboGo_RegulationOfLeukocyteActivation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","leukocyte","activation","."),3989090). assertion_content_comment('tOboGo_RegulationOfLeukocyteApoptosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","leukocyte","apoptosis","."),3999356). assertion_content_comment('tOboGo_RegulationOfLeukocyteChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","leukocyte","chemotaxis","."),3997984). assertion_content_comment('tOboGo_RegulationOfLeukocyteDegranulation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","leukocyte","degranulation","."),4093469). assertion_content_comment('tOboGo_RegulationOfLeukocyteMediatedCytotoxicity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","leukocyte","mediated","cytotoxicity","."),3983363). assertion_content_comment('tOboGo_RegulationOfLeukocyteMediatedImmunity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","leukocyte","mediated","immunity","."),3983275). assertion_content_comment('tOboGo_RegulationOfLeukocyteMigration',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","leukocyte","migration","."),3997822). assertion_content_comment('tOboGo_RegulationOfLeukocyteProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","leukocyte","proliferation","."),4061965). assertion_content_comment('tOboGo_RegulationOfLeukotrieneProductionInvolvedInInflammatoryResponse',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","synthesis","or","release","of","any","leukotriene","following","a","stimulus","as","part","of","an","inflammatory","response","."),4084373). assertion_content_comment('tOboGo_RegulationOfLigaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ligase","activity",",","the","catalysis","of","the","ligation","of","two","substances","with","concomitant","breaking","of","a","diphosphate","linkage",",","usually","in","a","nucleoside","triphosphate",".","Ligase","is","the","systematic","name","for","any","enzyme","of","EC","class","6","."),4012337). assertion_content_comment('tOboGo_RegulationOfLinearElementAssembly',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","linear","element","assembly",".","Linear","element","assembly","is","the","cell","cycle","process","in","which","a","proteinaceous","scaffold",",","related","to","the","synaptonemal","complex",",","is","assembled","in","association","with","S",".","pombe","chromosomes","during","meiotic","prophase","."),4149570). assertion_content_comment('tOboGo_RegulationOfLipaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lipase","activity",",","the","hydrolysis","of","a","lipid","or","phospholipid","."),4049025). assertion_content_comment('tOboGo_RegulationOfLipidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","lipids","."),4015704). assertion_content_comment('tOboGo_RegulationOfLipidCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lipids","."),4037727). assertion_content_comment('tOboGo_RegulationOfLipidKinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lipid","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","simple","or","complex","lipid","."),4155534). assertion_content_comment('tOboGo_RegulationOfLipidMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","lipids","."),4015640). assertion_content_comment('tOboGo_RegulationOfLipidStorage',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","lipid","storage",".","Lipid","storage","is","the","accumulation","and","maintenance","in","cells","or","tissues","of","lipids",",","compounds","soluble","in","organic","solvents","but","insoluble","or","sparingly","soluble","in","aqueous","solvents",".","Lipid","reserves","can","be","accumulated","during","early","developmental","stages","for","mobilization","and","utilization","at","later","stages","of","development","."),4037484). assertion_content_comment('tOboGo_RegulationOfLipidTransportByNegativeRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lipid","transport","by","stopping",",","preventing",",","or","reducing","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4159220). assertion_content_comment('tOboGo_RegulationOfLipidTransportByPositiveRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lipid","transport","by","activating","or","increasing","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4159188). assertion_content_comment('tOboGo_RegulationOfLipidTransportByRegulationOfTranscriptionFromAnRNAPolymeraseIIPromoter',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lipid","transport","by","modulating","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4159186). assertion_content_comment('tOboGo_RegulationOfLipidTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","lipids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4024619). assertion_content_comment('tOboGo_RegulationOfLipoproteinLipaseActivity',s("Any","process","that","modulates","the","activity","of","the","enzyme","lipoprotein","lipase","."),4279147). assertion_content_comment('tOboGo_RegulationOfLipoproteinLipidOxidation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","lipoprotein","lipid","oxidation",".","Lipoprotein","lipid","oxidation","is","the","modification","of","a","lipoprotein","by","oxidation","of","the","lipid","group","."),4116885). assertion_content_comment('tOboGo_RegulationOfLipoproteinMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","lipoproteins",",","any","conjugated",",","water-soluble","protein","in","which","the","nonprotein","group","consists","of","a","lipid","or","lipids","."),4074895). assertion_content_comment('tOboGo_RegulationOfLipoproteinOxidation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lipoprotein","oxidation","."),4074899). assertion_content_comment('tOboGo_RegulationOfLipoproteinParticleClearance',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","lipoprotein","particle","clearance",".","Lipoprotein","particle","clearance","is","the","process","in","which","a","lipoprotein","particle","is","removed","from","the","blood","via","receptor-mediated","endocytosis","and","its","constituent","parts","degraded","."),4035730). assertion_content_comment('tOboGo_RegulationOfLiquidSurfaceTension',s("Any","process","that","modulates","the","surface","tension","of","a","liquid",".","Surface","tension","is","the","property","that","makes","a","liquid","behave","as","if","it","had","an","elastic","skin","on","its","surface","at","the","interface","with","a","gas","or","an","immiscible","liquid","."),4237934). assertion_content_comment('tOboGo_RegulationOfLocalization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","any","process","in","which","a","cell",",","a","substance",",","or","a","cellular","entity","is","transported","to",",","or","maintained","in",",","a","specific","location","."),3988148). assertion_content_comment('tOboGo_RegulationOfLocomotionInvolvedInLocomotoryBehavior',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","self-propelled","movement","of","a","cell","or","organism","from","one","location","to","another","in","a","behavioral","context",";","the","aspect","of","locomotory","behavior","having","to","do","with","movement","."),4150553). assertion_content_comment('tOboGo_RegulationOfLocomotion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","locomotion","of","a","cell","or","organism","."),3997795). assertion_content_comment('tOboGo_RegulationOfLungBloodPressure',s("The","process","that","modulates","the","force","with","which","blood","travels","through","the","lungs",".","The","process","is","controlled","by","a","balance","of","processes","that","increase","pressure","and","decrease","pressure","."),4289248). assertion_content_comment('tOboGo_RegulationOfLuteinizingHormoneSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","luteinizing","hormone","."),4063008). assertion_content_comment('tOboGo_RegulationOfLyaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lyase","activity",",","the","catalysis","of","the","cleavage","of","C-C",",","C-O",",","C-N","and","other","bonds","by","other","means","than","by","hydrolysis","or","oxidation",",","or","conversely","adding","a","group","to","a","double","bond",".","They","differ","from","other","enzymes","in","that","two","substrates","are","involved","in","one","reaction","direction",",","but","only","one","in","the","other","direction",".","When","acting","on","the","single","substrate",",","a","molecule","is","eliminated","and","this","generates","either","a","new","double","bond","or","a","new","ring","."),4027763). assertion_content_comment('tOboGo_RegulationOfLymphocyteActivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lymphocyte","activation","."),3989095). assertion_content_comment('tOboGo_RegulationOfLymphocyteAnergy',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","lymphocyte","anergy","."),3998282). assertion_content_comment('tOboGo_RegulationOfLymphocyteApoptosis',s("Any","process","that","modulates","the","occurrence","or","rate","of","lymphocyte","death","by","apoptosis","."),3999359). assertion_content_comment('tOboGo_RegulationOfLymphocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lymphocyte","differentiation","."),3989099). assertion_content_comment('tOboGo_RegulationOfLymphocyteMediatedImmunity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","lymphocyte","mediated","immunity","."),3983305). assertion_content_comment('tOboGo_RegulationOfLymphocyteMigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lymphocyte","migration","."),4026072). assertion_content_comment('tOboGo_RegulationOfLymphocyteProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lymphocyte","proliferation","."),4061974). assertion_content_comment('tOboGo_RegulationOfLymphotoxinABiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","cytokine","lymphotoxin","A","."),4093951). assertion_content_comment('tOboGo_RegulationOfLymphotoxinAProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","lymphotoxin","A","production","."),4068359). assertion_content_comment('tOboGo_RegulationOfLysineImport',s("Any","process","that","modulates","the","rate","or","frequency","of","lysine","import",".","Lysine","import","is","the","directed","movement","of","lysine",",","2",",","6-diaminohexanoic","acid",",","into","a","cell","or","organelle","."),4025899). assertion_content_comment('tOboGo_RegulationOfLysosomalLumenPH',s("Any","process","that","modulates","the","pH","of","the","lysosomal","lumen",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4081453). assertion_content_comment('tOboGo_RegulationOfMacroautophagy',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","macroautophagy","."),4034036). assertion_content_comment('tOboGo_RegulationOfMacromoleculeBiosyntheticProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","macromolecule",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3970951). assertion_content_comment('tOboGo_RegulationOfMacromoleculeMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","macromolecules",",","any","molecule","of","high","relative","molecular","mass",",","the","structure","of","which","essentially","comprises","the","multiple","repetition","of","units","derived",",","actually","or","conceptually",",","from","molecules","of","low","relative","molecular","mass","."),3969144). assertion_content_comment('tOboGo_RegulationOfMacrophageActivation',s("Any","process","that","modulates","the","frequency","or","rate","of","macrophage","activation","."),4094056). assertion_content_comment('tOboGo_RegulationOfMacrophageAntigenProcessingAndPresentation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","macrophage","antigen","processing","and","presentation","."),3994549). assertion_content_comment('tOboGo_RegulationOfMacrophageApoptosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","macrophage","apoptosis","."),4138392). assertion_content_comment('tOboGo_RegulationOfMacrophageChemotaxis',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","macrophage","chemotaxis",".","Macrophage","chemotaxis","is","the","movement","of","a","macrophage","in","response","to","an","external","stimulus","."),4024982). assertion_content_comment('tOboGo_RegulationOfMacrophageCytokineProduction',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","macrophage","cytokine","production",".","Macrophage","cytokine","production","is","the","appearance","of","a","chemokine","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4034920). assertion_content_comment('tOboGo_RegulationOfMacrophageDerivedFoamCellDifferentiation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","macrophage","derived","foam","cell","differentiation",".","Macrophage","derived","foam","cell","differentiation","is","the","process","in","which","a","macrophage","acquires","the","specialized","features","of","a","foam","cell",".","A","foam","cell","is","a","type","of","cell","containing","lipids","in","small","vacuoles","and","typically","seen","in","atherosclerotic","lesions",",","as","well","as","other","conditions","."),4024660). assertion_content_comment('tOboGo_RegulationOfMacrophageDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","macrophage","differentiation","."),4087701). assertion_content_comment('tOboGo_RegulationOfMacrophageFusion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","macrophage","fusion","."),4075716). assertion_content_comment('tOboGo_RegulationOfMacrophageInflammatoryProtein1AlphaProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","macrophage","inflammatory","protein","1","alpha","."),4130105). assertion_content_comment('tOboGo_RegulationOfMacrophageMigrationInhibitoryFactorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","macrophage","migration","inhibitory","factor","signaling","pathway","."),4142352). assertion_content_comment('tOboGo_RegulationOfMacrophageToleranceInduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B","cell","tolerance","induction","."),4034981). assertion_content_comment('tOboGo_RegulationOfMaintenanceOfBipolarCellPolarityRegulatingCellShape',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","maintenance","of","bipolar","cell","polarity","regulating","in","cell","shape","."),4133697). assertion_content_comment('tOboGo_RegulationOfMaintenanceOfMeioticSisterChromatidCohesion',s("Any","process","that","modulates","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","during","a","meiotic","cell","cycle","."),4076617). assertion_content_comment('tOboGo_RegulationOfMaintenanceOfMitoticSisterChromatidCohesion',s("Any","process","that","modulates","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","during","a","mitotic","cell","cycle","."),4076045). assertion_content_comment('tOboGo_RegulationOfMaintenanceOfSisterChromatidCohesion',s("Any","process","that","modulates","the","extent","to","which","the","association","between","sister","chromatids","of","a","replicated","chromosome","is","maintained","."),4076012). assertion_content_comment('tOboGo_RegulationOfMaleGermCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","male","germ","cell","proliferation","."),4140343). assertion_content_comment('tOboGo_RegulationOfMaleGonadDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","male","gonad","development","."),4139411). assertion_content_comment('tOboGo_RegulationOfMalePigmentation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","of","a","pattern","of","pigment","in","males","."),4104328). assertion_content_comment('tOboGo_RegulationOfMalpighianTubuleDiameter',s("Ensuring","that","the","Malpighian","tubule","is","the","correct","width",".","Malpighian","tubules","have","a","uniform","circumference","along","their","length",";","the","circumference","of","the","tubes","is","eight","cells","during","the","time","the","cells","are","dividing",",","after","which","the","cells","rearrange","producting","tubes","with","a","cirumference","of","two","cells","."),4071254). assertion_content_comment('tOboGo_RegulationOfMalpighianTubuleSize',s("Ensuring","that","a","Malpighian","tubule","is","the","correct","length","and","diameter","."),4071214). assertion_content_comment('tOboGo_RegulationOfMammaryGlandEpithelialCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mammary","gland","epithelial","cell","proliferation","."),4063429). assertion_content_comment('tOboGo_RegulationOfMammaryStemCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mammary","stem","cell","proliferation","."),4138423). assertion_content_comment('tOboGo_RegulationOfMAPKExportFromNucleus',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","MAP","kinase","from","the","nucleus","to","the","cytoplasm","."),4129324). assertion_content_comment('tOboGo_RegulationOfMAPKinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","MAP","kinase","activity","."),3972513). assertion_content_comment('tOboGo_RegulationOfMAPKKKCascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","MAPKKK","cascade","."),4016595). assertion_content_comment('tOboGo_RegulationOfMastCellActivationInvolvedInImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","mast","cell","activation","as","part","of","an","immune","response","."),4065218). assertion_content_comment('tOboGo_RegulationOfMastCellActivation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","mast","cell","activation","."),4065203). assertion_content_comment('tOboGo_RegulationOfMastCellApoptosis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","mast","cell","apoptosis","."),4065121). assertion_content_comment('tOboGo_RegulationOfMastCellChemotaxis',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","mast","cell","chemotaxis",".","Mast","cell","chemotaxis","is","the","movement","of","a","mast","cell","in","response","to","an","external","stimulus","."),4110459). assertion_content_comment('tOboGo_RegulationOfMastCellCytokineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","mast","cell","cytokine","production","."),4068956). assertion_content_comment('tOboGo_RegulationOfMastCellDegranulation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","mast","cell","degranulation","."),4093674). assertion_content_comment('tOboGo_RegulationOfMastCellDifferentiation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","mast","cell","differentiation",",","the","process","in","which","a","relatively","unspecialized","myeloid","precursor","cell","acquires","the","specialized","features","of","a","mast","cell",".","A","mast","cell","is","a","cell","that","is","found","in","almost","all","tissues","containing","numerous","basophilic","granules","and","capable","of","releasing","large","amounts","of","histamine","and","heparin","upon","activation","."),4114966). assertion_content_comment('tOboGo_RegulationOfMastCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mast","cell","proliferation","."),4130457). assertion_content_comment('tOboGo_RegulationOfMatingProjectionAssembly',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","mating","projection","formation","by","unicellular","fungi","."),4058554). assertion_content_comment('tOboGo_RegulationOfMatingTypeSwitching',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mating","type","switching",",","the","conversion","of","a","single-cell","organism","from","one","mating","type","to","another","by","the","precise","replacement","of","a","DNA","sequence","at","the","expressed","mating","type","locus","with","a","copy","of","a","sequence","from","a","donor","locus","."),4060843). assertion_content_comment('tOboGo_RegulationOfMatureBCellApoptosis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","mature","B","cell","apoptosis","."),3999604). assertion_content_comment('tOboGo_RegulationOfMechanoreceptorDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mechanoreceptor","differentiation","."),4033469). assertion_content_comment('tOboGo_RegulationOfMegakaryocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","megakaryocyte","differentiation","."),4087760). assertion_content_comment('tOboGo_RegulationOfMeiosisI',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","meiosis","I",",","a","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","first","phase","of","meiosis",",","in","which","cells","divide","and","homologous","chromosomes","are","paired","and","segregated","from","each","other",",","producing","two","daughter","cells","."),4030095). assertion_content_comment('tOboGo_RegulationOfMeiosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","meiosis",",","the","process","in","which","the","nucleus","of","a","diploid","cell","divides","twice","forming","four","haploid","cells",",","one","or","more","of","which","usually","function","as","gametes","."),4030092). assertion_content_comment('tOboGo_RegulationOfMeioticCellCycle',s("Any","process","that","modulates","the","rate","or","extent","of","progression","through","the","meiotic","cell","cycle","."),4030081). assertion_content_comment('tOboGo_RegulationOfMeioticJointMoleculeFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","meiotic","joint","molecule","formation",".","Meiotic","joint","molecule","formation","is","the","conversion","of","the","paired","broken","DNA","and","homologous","duplex","DNA","into","a","four-stranded","branched","intermediate",",","known","as","a","joint","molecule",",","formed","during","meiotic","recombination","."),4034857). assertion_content_comment('tOboGo_RegulationOfMelaninBiosyntheticProcess',s("Any","process","that","alters","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","melanin","."),4104455). assertion_content_comment('tOboGo_RegulationOfMelanizationDefenseResponse',s("Any","process","that","affects","the","rate",",","extent","or","location","of","the","melanization","defense","response","during","injury","or","invasion","."),4072452). assertion_content_comment('tOboGo_RegulationOfMelanocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","melanocyte","differentiation","."),4086927). assertion_content_comment('tOboGo_RegulationOfMembraneDepolarization',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","membrane","depolarization",".","Membrane","depolarization","is","the","process","in","which","membrane","potential","changes","in","the","depolarizing","direction","from","the","resting","potential",",","usually","from","negative","to","positive","."),4003123). assertion_content_comment('tOboGo_RegulationOfMembraneDisassembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","membrane","disassembly","."),4027200). assertion_content_comment('tOboGo_RegulationOfMembraneLipidDistribution',s("Any","process","that","modulates","the","proportions","or","spatial","arrangement","of","lipids","in","a","cellular","membrane","."),4074212). assertion_content_comment('tOboGo_RegulationOfMembranePotentialInPhotoreceptorCell',s("Hyperpolarization","(","vertebrates",")","or","depolarization","(","invertebrates",")","of","the","photoreceptor","cell","membrane","via","closing/opening","of","cation","specific","channels","as","a","result","of","signals","generated","by","rhodopsin","activation","by","a","photon","."),4033754). assertion_content_comment('tOboGo_RegulationOfMembraneProteinEctodomainProteolysis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","proteolytic","cleavage","of","transmembrane","proteins","and","release","of","their","ectodomain","(","extracellular","domain",")"),4119251). assertion_content_comment('tOboGo_RegulationOfMembraneRepolarization',s("Any","process","that","modulates","the","establishment","or","extent","of","a","membrane","potential","in","the","polarizing","direction","towards","the","resting","potential",",","usually","from","positive","to","negative","."),4160325). assertion_content_comment('tOboGo_RegulationOfMemoryTCellActivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","memory","T","cell","activation","."),4144252). assertion_content_comment('tOboGo_RegulationOfMemoryTCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","memory","T","cell","differentiation","."),4095728). assertion_content_comment('tOboGo_RegulationOfMeristemDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","meristem","development",",","the","biological","process","whose","specific","outcome","is","the","progression","of","the","meristem","over","time",",","from","its","formation","to","the","mature","structure","."),4032147). assertion_content_comment('tOboGo_RegulationOfMeristemGrowth',s("Any","process","involved","in","maintaining","the","size","and","shape","of","a","meristem","."),4032152). assertion_content_comment('tOboGo_RegulationOfMeristemStructuralOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","meristem","organization","."),4033349). assertion_content_comment('tOboGo_RegulationOfMesenchymalCellProliferationInvolvedInProstateGlandDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesenchymal","cell","proliferation","that","contributes","to","the","progression","of","the","prostate","gland","over","time",".","A","mesenchymal","cell","is","a","cell","that","normally","gives","rise","to","other","cells","that","are","organized","as","three-dimensional","masses",",","rather","than","sheets","."),4110904). assertion_content_comment('tOboGo_RegulationOfMesenchymalCellProliferationInvolvedInUreterDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesenchymal","cell","proliferation","that","contributes","to","the","progression","of","the","ureter","gland","over","time",".","A","mesenchymal","cell","is","a","cell","that","normally","gives","rise","to","other","cells","that","are","organized","as","three-dimensional","masses",",","rather","than","sheets","."),4124863). assertion_content_comment('tOboGo_RegulationOfMesenchymalCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesenchymal","cell","proliferation",".","A","mesenchymal","cell","is","a","cell","that","normally","gives","rise","to","other","cells","that","are","organized","as","three-dimensional","masses",",","rather","than","sheets","."),3990417). assertion_content_comment('tOboGo_RegulationOfMesenchymalStemCellApoptosisInvolvedInMesonephricNephronMorphogenesis',s("Any","process","that","modulates","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephron","in","the","mesonephros","."),4134676). assertion_content_comment('tOboGo_RegulationOfMesenchymalStemCellApoptosisInvolvedInMetanephricNephronMorphogenesis',s("Any","process","that","modulates","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephron","in","the","metanephros","."),4124645). assertion_content_comment('tOboGo_RegulationOfMesenchymalStemCellApoptosisInvolvedInNephronMorphogenesis',s("Any","process","that","modulates","the","occurrence","or","rate","of","mesenchymal","stem","cell","death","by","apoptosis","that","contributes","to","the","shaping","of","the","nephron","."),4123600). assertion_content_comment('tOboGo_RegulationOfMesenchymalStemCellProliferationInvolvedInNephronMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesenchymal","stem","cell","proliferation","and","contributes","to","the","shaping","of","a","nephron","."),4123521). assertion_content_comment('tOboGo_RegulationOfMesenchymalToEpithelialTransitionInvolvedInMesonephrosMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesenchymal","to","epithelial","transition","involved","in","mesonephros","morphogenesis","."),4138271). assertion_content_comment('tOboGo_RegulationOfMesenchymalToEpithelialTransitionInvolvedInMetanephrosMorphogenesis',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","transition","where","a","mesenchymal","cell","establishes","apical/basolateral","polarity",",","forms","intercellular","adhesive","junctions",",","synthesizes","basement","membrane","components","and","becomes","an","epithelial","cell","that","will","contribute","to","the","shaping","of","the","metanephros","."),4006212). assertion_content_comment('tOboGo_RegulationOfMesodermalCellFateDetermination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesoderm","cell","fate","determination","."),4102114). assertion_content_comment('tOboGo_RegulationOfMesodermalCellFateSpecification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesoderm","cell","fate","specification","."),4078092). assertion_content_comment('tOboGo_RegulationOfMesodermDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesoderm","development","."),4078089). assertion_content_comment('tOboGo_RegulationOfMesonephricGlomerularMesangialCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesonephric","glomerular","mesangial","cell","proliferation","."),4138192). assertion_content_comment('tOboGo_RegulationOfMesonephricGlomerulusDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesonephric","glomerulus","development","."),4138178). assertion_content_comment('tOboGo_RegulationOfMesonephricNephronTubuleEpithelialCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mesonephric","nephron","tubule","epithelial","cell","differentiation","."),4138140). assertion_content_comment('tOboGo_RegulationOfMesonephrosDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","mesonephros","development",".","Mesonephros","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","mesonephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","mesonephros","is","an","endocrine","and","metabolic","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4134661). assertion_content_comment('tOboGo_RegulationOfMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","within","a","cell","or","an","organism","."),3969086). assertion_content_comment('tOboGo_RegulationOfMetalIonTransport',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","metal","ion","transport",".","Metal","ion","transport","is","the","directed","movement","of","metal","ions",",","any","metal","ion","with","an","electric","charge",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3991154). assertion_content_comment('tOboGo_RegulationOfMetalloenzymeActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","activity","of","a","metalloenzyme",".","A","metalloenzyme","is","any","enzyme","that","contains","metal","."),4332312). assertion_content_comment('tOboGo_RegulationOfMetanephricCapMesenchymalCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","metanephric","cap","mesenchymal","cell","proliferation",".","Metanephric","cap","mesenchymal","cell","proliferation","is","the","multiplication","or","reproduction","of","metanephric","cap","mesenchymal","cells",",","resulting","in","the","expansion","of","the","cell","population",".","A","metanephric","cap","mesenchymal","cell","is","a","mesenchymal","cell","that","has","condensed","with","other","mesenchymal","cells","surrounding","the","ureteric","bud","tip","."),4150214). assertion_content_comment('tOboGo_RegulationOfMetanephricDCTCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","metanephric","DCT","cell","differentiation","."),4144418). assertion_content_comment('tOboGo_RegulationOfMetanephricGlomerularMesangialCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","metanephric","glomerular","mesangial","cell","proliferation","."),4124560). assertion_content_comment('tOboGo_RegulationOfMetanephricGlomerularVisceralEpithelialCellDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","metanephric","glomerular","visceral","epithelial","cell","development","."),4145481). assertion_content_comment('tOboGo_RegulationOfMetanephricGlomerulusDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","metanephric","glomerulus","development",",","the","progression","of","the","metanephric","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","metanephric","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney",",","or","metanephros","."),4124534). assertion_content_comment('tOboGo_RegulationOfMetanephricMesenchymalCellMigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","metanephric","mesenchymal","cell","migration","."),4144532). assertion_content_comment('tOboGo_RegulationOfMetanephricNephronTubuleEpithelialCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","metanephric","nephron","tubule","epithelial","cell","differentiation","."),4124678). assertion_content_comment('tOboGo_RegulationOfMetanephrosDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","metanephros","development",".","Metanephros","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","metanephros","over","time",",","from","its","formation","to","the","mature","structure",".","The","metanephros","is","an","endocrine","and","metabolic","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4006208). assertion_content_comment('tOboGo_RegulationOfMetanephrosSize',s("Any","process","that","modulates","the","size","of","a","metanephric","kidney","."),4082325). assertion_content_comment('tOboGo_RegulationOfMetaphasePlateCongression',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","metaphase","plate","congression",",","the","alignment","of","chromosomes","at","the","metaphase","plate",",","a","plane","halfway","between","the","poles","of","the","spindle","."),4151653). assertion_content_comment('tOboGo_RegulationOfMetaxylemDevelopment',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","metaxylem","development",".","Metaxylem","development","is","the","process","whose","specific","outcome","is","the","progression","of","the","metaxylem","over","time",",","from","its","formation","to","the","mature","structure",".","The","metaxylem","is","the","part","of","the","primary","xylem","that","differentiates","after","the","protoxylem","and","before","the","secondary","xylem",",","if","any","of","the","latter","is","formed","."),4150062). assertion_content_comment('tOboGo_RegulationOfMetulaDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","metula","development",",","a","process","that","leads","to","the","formation","of","metulae",".","Metulae","are","elongated","mononucleate","cells","that","bud","from","the","surface","of","the","conidiophore","tip","."),4132560). assertion_content_comment('tOboGo_RegulationOfMG1TransitionOfMitoticCellCycle',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","M/G1","transition","of","the","mitotic","cell","cycle",",","the","progression","from","M","phase","to","G1","phase","of","the","mitotic","cell","cycle","."),4111765). assertion_content_comment('tOboGo_RegulationOfMHCClassIBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","MHC","class","I","."),4085828). assertion_content_comment('tOboGo_RegulationOfMHCClassIIBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","MHC","class","II","."),4085867). assertion_content_comment('tOboGo_RegulationOfMicrogliaDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","microglia","differentiation",",","the","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","microglial","cell","."),4036242). assertion_content_comment('tOboGo_RegulationOfMicrotubuleCytoskeletonOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","microtubules","and","their","associated","proteins","."),4013251). assertion_content_comment('tOboGo_RegulationOfMicrotubuleDepolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","microtubule","depolymerization","."),4013292). assertion_content_comment('tOboGo_RegulationOfMicrotubuleMotorActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","microtubule","motor","activity","."),4155705). assertion_content_comment('tOboGo_RegulationOfMicrotubuleNucleationByRanProteinSignalTransduction',s("Any","series","of","molecular","signals","in","which","a","Ran","GTPase","relays","one","or","more","of","the","signals","resulting","in","the","modulation","of","the","rate",",","frequency","or","extent","of","microtubule","nucleation","."),4155587). assertion_content_comment('tOboGo_RegulationOfMicrotubuleNucleation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","microtubule","nucleation",".","Microtubule","nucleation","is","the","'","de","novo","'","formation","of","a","microtubule",",","in","which","tubulin","heterodimers","form","metastable","oligomeric","aggregates",",","some","of","which","go","on","to","support","formation","of","a","complete","microtubule",".","Microtubule","nucleation","usually","occurs","from","a","specific","site","within","a","cell","."),4035606). assertion_content_comment('tOboGo_RegulationOfMicrotubulePolymerizationOrDepolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","microtubule","polymerization","or","depolymerization","by","the","addition","or","removal","of","tubulin","heterodimers","from","a","microtubule","."),4013256). assertion_content_comment('tOboGo_RegulationOfMicrotubulePolymerization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","microtubule","polymerization","."),4062618). assertion_content_comment('tOboGo_RegulationOfMicrovillusAssembly',s("A","process","that","modulates","the","formation","of","a","microvillus","."),4067372). assertion_content_comment('tOboGo_RegulationOfMicrovillusLength',s("A","process","that","modulates","the","length","of","a","microvillus","."),4331409). assertion_content_comment('tOboGo_RegulationOfMicrovillusOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","microvillus","."),4067367). assertion_content_comment('tOboGo_RegulationOfMiRNACatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","miRNA","catabolic","process","."),4144022). assertion_content_comment('tOboGo_RegulationOfMiRNAMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","miRNA","metabolic","process","."),4143978). assertion_content_comment('tOboGo_RegulationOfMismatchRepair',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mismatch","repair","."),4055541). assertion_content_comment('tOboGo_RegulationOfMitochondrialDepolarization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","change","in","the","membrane","potential","of","the","mitochondria","from","negative","to","positive","."),4120186). assertion_content_comment('tOboGo_RegulationOfMitochondrialDNAReplication',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","process","in","which","new","strands","of","DNA","are","synthesized","in","the","mitochondrion","."),4152072). assertion_content_comment('tOboGo_RegulationOfMitochondrialFission',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","mitochondrial","fission",".","Mitochondrial","fission","is","the","division","of","a","mitochondrion","within","a","cell","to","form","two","or","more","separate","mitochondrial","compartments","."),4149113). assertion_content_comment('tOboGo_RegulationOfMitochondrialFusion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","merging","of","two","or","more","mitochondria","within","a","cell","to","form","a","single","compartment","."),4028711). assertion_content_comment('tOboGo_RegulationOfMitochondrialMembranePermeability',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","passage","or","uptake","of","molecules","by","the","mitochondrial","membrane","."),4099781). assertion_content_comment('tOboGo_RegulationOfMitochondrialMembranePotential',s("Any","process","that","modulates","the","establishment","or","extent","of","the","mitochondrial","membrane","potential",",","the","electric","potential","existing","across","the","mitochondrial","membrane","arising","from","charges","in","the","membrane","itself","and","from","the","charges","present","in","the","media","on","either","side","of","the","membrane","."),4120160). assertion_content_comment('tOboGo_RegulationOfMitochondrialRNACatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","catabolism","in","the","mitochondrion","of","RNA","transcribed","from","the","mitochondrial","genome","."),3979604). assertion_content_comment('tOboGo_RegulationOfMitochondrialTranslationalInitiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","process","preceding","formation","of","the","peptide","bond","between","the","first","two","amino","acids","of","a","protein","in","a","mitochondrion","."),4133202). assertion_content_comment('tOboGo_RegulationOfMitochondrialTranslation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","proteins","by","the","translation","of","mRNA","in","a","mitochondrion","."),4133180). assertion_content_comment('tOboGo_RegulationOfMitochondrionOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","mitochondrion","."),4028707). assertion_content_comment('tOboGo_RegulationOfMitosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mitosis","."),4012177). assertion_content_comment('tOboGo_RegulationOfMitoticAnaphase',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mitotic","anaphase",",","a","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","anaphase",",","the","stage","of","mitosis","during","which","the","two","sets","of","chromosomes","separate","and","move","away","from","each","other","."),4149594). assertion_content_comment('tOboGo_RegulationOfMitoticCellCycleEmbryonic',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","replication","and","segregation","of","genetic","material","in","the","embryo","."),4019137). assertion_content_comment('tOboGo_RegulationOfMitoticCellCycle',s("Any","process","that","modulates","the","rate","or","extent","of","progress","through","the","mitotic","cell","cycle","."),3980358). assertion_content_comment('tOboGo_RegulationOfMitoticCellCycleSpindleAssemblyCheckpoint',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","mitotic","cell","cycle","spindle","assembly","checkpoint",",","a","cell","cycle","checkpoint","that","delays","the","metaphase/anaphase","transition","of","a","mitotic","nuclear","division","until","the","spindle","is","correctly","assembled","and","chromosomes","are","attached","to","the","spindle","."),4151826). assertion_content_comment('tOboGo_RegulationOfMitoticCentrosomeSeparation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","separation","of","duplicated","centrosome","components","at","the","beginning","of","mitosis","."),4098682). assertion_content_comment('tOboGo_RegulationOfMitoticMetaphaseAnaphaseTransition',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","onset","of","anaphase","(","chromosome","movement",")","in","the","mitotic","cell","cycle","."),4012190). assertion_content_comment('tOboGo_RegulationOfMitoticPrometaphase',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mitotic","prometaphase",",","the","stage","following","prophase","in","mitosis","(","in","higher","eukaryotes",")","during","which","the","nuclear","envelope","is","disrupted","and","breaks","into","membrane","vesicles",",","and","the","spindle","microtubules","enter","the","nuclear","region","."),4082942). assertion_content_comment('tOboGo_RegulationOfMitoticRecombination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","recombination","during","mitosis","."),3969372). assertion_content_comment('tOboGo_RegulationOfMitoticSisterChromatidSegregation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","sister","chromatid","segregation","during","mitosis","."),4035650). assertion_content_comment('tOboGo_RegulationOfMitoticSisterChromatidSeparation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mitotic","sister","chromatid","separation",".","Mitotic","sister","chromatid","separation","is","the","process","in","which","sister","chromatids","are","physically","detached","from","each","other","during","mitosis","."),4035653). assertion_content_comment('tOboGo_RegulationOfMitoticSpindleElongation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","cell","cycle","process","in","which","the","distance","is","lengthened","between","poles","of","the","mitotic","spindle","."),4064661). assertion_content_comment('tOboGo_RegulationOfMitoticSpindleOrganization',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","microtubule","spindle","during","a","mitotic","cell","cycle","."),4064657). assertion_content_comment('tOboGo_RegulationOfMolecularFunctionEpigenetic',s("Any","heritable","epigenetic","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","function","by","self-perpetuating","conformational","conversions","of","normal","proteins","in","healthy","cells",".","This","is","distinct","from",",","though","mechanistically","analogous","to",",","disease","states","associated","with","prion","propagation","and","amyloidogenesis",".","A","single","protein",",","if","it","carries","a","glutamine/asparagine-rich","(","'","prion","'",")","domain",",","can","sometimes","stably","exist","in","at","least","two","distinct","physical","states",",","each","associated","with","a","different","phenotype",";","propagation","of","one","of","these","traits","is","achieved","by","a","self-perpetuating","change","in","the","protein","from","one","form","to","the","other",",","mediated","by","conformational","changes","in","the","glutamine/asparagine-rich","domain",".","Prion","domains","are","both","modular","and","transferable","to","other","proteins",",","on","which","they","can","confer","a","heritable","epigenetic","alteration","of","function",";","existing","bioinformatics","data","indicate","that","they","are","rare","in","non-eukarya",",","but","common","in","eukarya","."),4232538). assertion_content_comment('tOboGo_RegulationOfMolecularFunction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","molecular","function",",","an","elemental","biological","activity","occurring","at","the","molecular","level",",","such","as","catalysis","or","binding","."),3972498). assertion_content_comment('tOboGo_RegulationOfMonocyteAntigenProcessingAndPresentation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","monocyte","antigen","processing","and","presentation","."),3994599). assertion_content_comment('tOboGo_RegulationOfMonocyteChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","monocyte","chemotaxis","."),4149857). assertion_content_comment('tOboGo_RegulationOfMonocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","monocyte","differentiation","."),4087323). assertion_content_comment('tOboGo_RegulationOfMonocyteExtravasation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","monocyte","extravasation","."),4142033). assertion_content_comment('tOboGo_RegulationOfMononuclearCellMigration',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","mononuclear","cell","migration",".","Mononuclear","cell","migration","is","the","movement","of","a","mononuclear","cell","within","or","between","different","tissues","and","organs","of","the","body","."),4025033). assertion_content_comment('tOboGo_RegulationOfMononuclearCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mononuclear","cell","proliferation","."),4061968). assertion_content_comment('tOboGo_RegulationOfMonooxygenaseActivity',s("Any","process","that","modulates","the","activity","of","a","monooxygenase","."),4014255). assertion_content_comment('tOboGo_RegulationOfMonophenolMonooxygenaseActivity',s("Any","process","that","modulates","the","activity","of","the","enzyme","monophenol","monooxygenase",".","Monophenol","monooxygenase","catalyzes","the","reaction",":","L-tyrosine","+","L-DOPA","+","O2","=","L-DOPA","+","DOPAquinone","+","H2O","."),4337491). assertion_content_comment('tOboGo_RegulationOfMonopolarCellGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","monopolar","cell","growth",",","polarized","growth","from","one","end","of","a","cell","."),4118699). assertion_content_comment('tOboGo_RegulationOfMorphogenesisOfABranchingStructure',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","branching","morphogenesis",",","the","process","in","which","the","anatomical","structures","of","branches","are","generated","and","organized","."),4111046). assertion_content_comment('tOboGo_RegulationOfMRNACatabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","a","mRNA","catabolic","process",",","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","RNA",",","ribonucleic","acid",",","one","of","the","two","main","type","of","nucleic","acid",",","consisting","of","a","long",",","unbranched","macromolecule","formed","from","ribonucleotides","joined","in","3","'",",","5","'","-phosphodiester","linkage","."),4113242). assertion_content_comment('tOboGo_RegulationOfMRNACleavage',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mRNA","cleavage",",","any","process","in","which","a","pre-mRNA","or","mRNA","molecule","is","cleaved","at","specific","sites","or","in","a","regulated","manner","."),4058257). assertion_content_comment('tOboGo_RegulationOfMRNAExportFromNucleus',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","mRNA","from","the","nucleus","to","the","cytoplasm","."),4025572). assertion_content_comment('tOboGo_RegulationOfMRNAModification',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","covalent","alteration","of","one","or","more","nucleotides","within","an","mRNA","molecule","to","produce","an","mRNA","molecule","with","a","sequence","that","differs","from","that","coded","genetically","."),4150962). assertion_content_comment('tOboGo_RegulationOfMRNAProcessing',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mRNA","processing",",","those","processes","involved","in","the","conversion","of","a","primary","mRNA","transcript","into","a","mature","mRNA","prior","to","its","translation","into","polypeptide","."),3974758). assertion_content_comment('tOboGo_RegulationOfMRNAStabilityInvolvedInResponseToStress',s("Any","process","that","modulates","the","propensity","of","mRNA","molecules","to","degradation","that","is","part","of","a","change","in","state","or","activity","of","a","cell","as","a","result","of","an","exogenous","disturbance","."),4028346). assertion_content_comment('tOboGo_RegulationOfMRNAStability',s("Any","process","that","modulates","the","propensity","of","mRNA","molecules","to","degradation",".","Includes","processes","that","both","stabilize","and","destabilize","mRNAs","."),4028343). assertion_content_comment('tOboGo_RegulationOfMucusSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","mucus","from","a","cell","or","group","of","cells","."),4137159). assertion_content_comment('tOboGo_RegulationOfMulticellularOrganismalDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","multicellular","organismal","development","."),3985483). assertion_content_comment('tOboGo_RegulationOfMulticellularOrganismalMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chemical","reactions","and","pathways","in","multicellular","organisms","that","occur","at","the","tissue",",","organ",",","or","organismal","level","."),3991044). assertion_content_comment('tOboGo_RegulationOfMulticellularOrganismalProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","multicellular","organismal","process",",","the","processes","pertinent","to","the","function","of","a","multicellular","organism","above","the","cellular","level",";","includes","the","integrated","processes","of","tissues","and","organs","."),3984230). assertion_content_comment('tOboGo_RegulationOfMulticellularOrganismGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","growth","of","the","body","of","an","organism","so","that","it","reaches","its","usual","body","size","."),3990942). assertion_content_comment('tOboGo_RegulationOfMultivesicularBodySizeInvolvedInEndosomeTransport',s("Any","process","that","modulates","the","volume","of","a","multivesicular","body","as","part","of","the","directed","movement","of","substances","from","endosomes","to","lysosomes","or","vacuoles","."),4025611). assertion_content_comment('tOboGo_RegulationOfMultivesicularBodySize',s("Any","process","that","modulates","the","volume","of","a","multivesicular","body",",","a","type","of","late","endosome","in","which","regions","of","the","limiting","endosomal","membrane","invaginate","to","form","internal","vesicles","."),4025608). assertion_content_comment('tOboGo_RegulationOfMuscleAdaptation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","adaptation","."),4028289). assertion_content_comment('tOboGo_RegulationOfMuscleAtrophy',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","atrophy","."),4040366). assertion_content_comment('tOboGo_RegulationOfMuscleCellApoptosis',s("Any","process","that","modulates","the","rate","or","frequency","of","muscle","cell","apoptosis",".","Muscle","cell","apoptosis","is","a","form","of","programmed","cell","death","induced","by","external","or","internal","signals","that","trigger","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","a","muscle","cell","and","result","in","its","death","."),4026241). assertion_content_comment('tOboGo_RegulationOfMuscleCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","cell","differentiation","."),4020022). assertion_content_comment('tOboGo_RegulationOfMuscleContraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","contraction","."),3999103). assertion_content_comment('tOboGo_RegulationOfMuscleFilamentSlidingInvolvedInRegulationOfTheVelocityOfShorteningInSkeletalMuscleContraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","filament","sliding",",","and","consequently","contributes","to","the","regulation","of","the","velocity","of","shortening","of","skeletal","muscle","contraction","."),4038941). assertion_content_comment('tOboGo_RegulationOfMuscleFilamentSliding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","filament","sliding","."),4038938). assertion_content_comment('tOboGo_RegulationOfMuscleFilamentSlidingSpeedInvolvedInRegulationOfTheVelocityOfShorteningInSkeletalMuscleContraction',s("Any","process","that","modulates","the","velocity","of","muscle","filament","sliding",",","and","consequently","contributes","to","the","regulation","of","the","velocity","of","shortening","of","skeletal","muscle","contraction","."),4289300). assertion_content_comment('tOboGo_RegulationOfMuscleFilamentSlidingSpeed',s("Any","process","that","modulates","the","velocity","of","muscle","filament","sliding","."),4289298). assertion_content_comment('tOboGo_RegulationOfMuscleHyperplasia',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","hyperplasia","."),4039992). assertion_content_comment('tOboGo_RegulationOfMuscleHypertrophy',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","hypertrophy","."),4028310). assertion_content_comment('tOboGo_RegulationOfMuscleOrganDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","muscle","development","."),4019998). assertion_content_comment('tOboGo_RegulationOfMuscleSystemProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","muscle","system","process",",","a","multicellular","organismal","process","carried","out","by","any","of","the","organs","or","tissues","in","a","muscle","system","."),3999100). assertion_content_comment('tOboGo_RegulationOfMyelination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","of","a","myelin","sheath","around","nerve","axons","."),4059858). assertion_content_comment('tOboGo_RegulationOfMyeloidCellApoptosis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","myeloid","cell","apoptosis","."),4065014). assertion_content_comment('tOboGo_RegulationOfMyeloidCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","myeloid","cell","differentiation","."),3996706). assertion_content_comment('tOboGo_RegulationOfMyeloidDendriticCellActivation',s("Any","process","that","modulates","the","frequency","or","rate","of","myeloid","dendritic","cell","activation","."),4061891). assertion_content_comment('tOboGo_RegulationOfMyeloidDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","myeloid","dendritic","cell","antigen","processing","and","presentation","."),3994740). assertion_content_comment('tOboGo_RegulationOfMyeloidDendriticCellChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","myeloid","dendritic","cell","chemotaxis","."),4144662). assertion_content_comment('tOboGo_RegulationOfMyeloidDendriticCellCytokineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","myeloid","dendritic","cell","cytokine","production","."),3998755). assertion_content_comment('tOboGo_RegulationOfMyeloidLeukocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","myeloid","leukocyte","differentiation","."),3996709). assertion_content_comment('tOboGo_RegulationOfMyeloidLeukocyteMediatedImmunity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","myeloid","leukocyte","mediated","immunity","."),3983280). assertion_content_comment('tOboGo_RegulationOfMyoblastDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","myoblast","differentiation",".","A","myoblast","is","a","mononucleate","cell","type","that",",","by","fusion","with","other","myoblasts",",","gives","rise","to","the","myotubes","that","eventually","develop","into","skeletal","muscle","fibers","."),4087372). assertion_content_comment('tOboGo_RegulationOfMyoblastProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","myoblast","proliferation","."),4140016). assertion_content_comment('tOboGo_RegulationOfMyofibrilNumber',s("Any","process","that","modulates","the","number","of","myofibrils",".","A","myofibril","is","the","contractile","element","of","skeletal","and","cardiac","muscle",".","It","is","a","long",",","highly","organized","bundle","of","actin",",","myosin",",","and","other","proteins","that","contracts","by","a","sliding","filament","mechanism","."),4321034). assertion_content_comment('tOboGo_RegulationOfMyofibrilSize',s("Any","process","that","modulates","the","size","of","myofibrils",".","A","myofibril","is","the","contractile","element","of","skeletal","and","cardiac","muscle",".","It","is","a","long",",","highly","organized","bundle","of","actin",",","myosin",",","and","other","proteins","that","contracts","by","a","sliding","filament","mechanism","."),4320979). assertion_content_comment('tOboGo_RegulationOfMyosinIIFilamentAssemblyOrDisassembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","or","disassembly","of","a","bipolar","filament","composed","of","myosin","II","molecules","."),4094479). assertion_content_comment('tOboGo_RegulationOfMyosinIIFilamentAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","of","a","bipolar","filament","composed","of","myosin","II","molecules","."),4094482). assertion_content_comment('tOboGo_RegulationOfMyosinIIFilamentDisassembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","disassembly","of","a","bipolar","filament","composed","of","myosin","II","molecules","."),4094515). assertion_content_comment('tOboGo_RegulationOfMyosinLightChainKinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","myosin","light","chain","kinase","activity","."),4379225). assertion_content_comment('tOboGo_RegulationOfMyotomeDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","myotome","development","."),4140054). assertion_content_comment('tOboGo_RegulationOfMyotubeDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","myotube","differentiation",".","Myotube","differentiation","is","the","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","myotube","cell",".","Myotubes","are","multinucleated","cells","that","are","formed","when","proliferating","myoblasts","exit","the","cell","cycle",",","differentiate","and","fuse","."),4036581). assertion_content_comment('tOboGo_RegulationOfNADKinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","NAD","kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","an","NAD","molecule","."),4341267). assertion_content_comment('tOboGo_RegulationOfNADPHOxidaseActivity',s("Any","process","that","modulates","the","activity","of","the","enzyme","NAD","(","P",")","H","oxidase","."),4343673). assertion_content_comment('tOboGo_RegulationOfNatriuresis',s("OBSOLETE",".","Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","natriuresis",",","the","process","of","renal","sodium","excretion","."),4193959). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellActivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","cell","activation","."),4070553). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellApoptosis',s("Any","process","that","modulates","the","occurrence","or","rate","of","natural","killer","cell","death","by","apoptosis","."),4137093). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","cell","chemotaxis","."),4145683). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellCytokineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","cytokine","production","."),3998629). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellDegranulation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","degranulation","."),4095511). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellDifferentiationInvolvedInImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","cell","differentiation","as","part","of","an","immune","response","."),4070758). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","cell","differentiation","."),4070732). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellMediatedCytotoxicityDirectedAgainstTumorCellTarget',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","cytotoxicity","directed","against","tumor","cell","target","."),4000099). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellMediatedCytotoxicity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","cytotoxicity","."),4000088). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellMediatedImmuneResponseToTumorCell',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","immune","response","to","a","tumor","cell","."),4000061). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellMediatedImmunity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","mediated","immunity","."),3998623). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellProliferationInvolvedInImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","cell","proliferation","as","part","of","an","immune","response","."),4070623). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","cell","proliferation","."),4070576). assertion_content_comment('tOboGo_RegulationOfNaturalKillerCellToleranceInduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","natural","killer","cell","tolerance","induction","."),4000673). assertion_content_comment('tOboGo_RegulationOfNecroptosis',s("Any","process","that","modulates","the","rate","frequency","or","extent","of","necroptosis",".","Necroptosis","is","a","necrotic","cell","death","process","that","results","from","the","activation","of","endogenous","cellular","processes",",","such","as","signaling","involving","death","domain","receptors","and","Toll-like","receptors","."),4116474). assertion_content_comment('tOboGo_RegulationOfNecroticCellDeath',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","necrotic","cell","death",".","Necrotic","cell","death","is","a","cell","death","process","that","is","morphologically","characterized","by","a","gain","in","cell","volume","(","oncosis",")",",","swelling","of","organelles",",","plasma","membrane","rupture","and","subsequent","loss","of","intracellular","contents","."),4034890). assertion_content_comment('tOboGo_RegulationOfNegativeChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","in","a","concentration","gradient","of","a","specific","chemical","."),4100244). assertion_content_comment('tOboGo_RegulationOfNematodeLarvalDevelopment',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","nematode","larval","development",",","the","process","whose","specific","outcome","is","the","progression","of","the","nematode","larva","over","time",",","from","its","formation","to","the","mature","structure",".","Nematode","larval","development","begins","with","the","newly","hatched","first-stage","larva","(","L1",")","and","ends","with","the","end","of","the","last","larval","stage","(","for","example","the","fourth","larval","stage","(","L4",")","in","C",".","elegans",")","Each","stage","of","nematode","larval","development","is","characterized","by","proliferation","of","specific","cell","lineages","and","an","increase","in","body","size","without","alteration","of","the","basic","body","plan",".","Nematode","larval","stages","are","separated","by","molts","in","which","each","stage-specific","exoskeleton",",","or","cuticle",",","is","shed","and","replaced","anew","."),4081874). assertion_content_comment('tOboGo_RegulationOfNephronTubuleEpithelialCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","nephron","tubule","epithelial","cell","differentiation","."),4123409). assertion_content_comment('tOboGo_RegulationOfNerveGrowthFactorProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","nerve","growth","factor","."),4064574). assertion_content_comment('tOboGo_RegulationOfNerveGrowthFactorReceptorActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","activity","of","the","nerve","growth","factor","receptor","."),4286241). assertion_content_comment('tOboGo_RegulationOfNerveGrowthFactorReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","activity","of","the","nerve","growth","factor","receptor","signaling","pathway","."),4118199). assertion_content_comment('tOboGo_RegulationOfNervousSystemDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","nervous","system","development",",","the","origin","and","formation","of","nervous","tissue","."),3990342). assertion_content_comment('tOboGo_RegulationOfNeuralCrestFormation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","neural","crest","formation",".","Neural","crest","formation","is","the","formation","of","the","specialized","region","of","ectoderm","between","the","neural","ectoderm","(","neural","plate",")","and","non-neural","ectoderm",".","The","neural","crest","gives","rise","to","the","neural","crest","cells","that","migrate","away","from","this","region","as","neural","tube","formation","procedes","."),4152044). assertion_content_comment('tOboGo_RegulationOfNeuralPrecursorCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","neural","precursor","cell","proliferation","."),3990372). assertion_content_comment('tOboGo_RegulationOfNeuralRetinaDevelopment',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","neural","retina","development",",","the","progression","of","the","neural","retina","over","time","from","its","initial","formation","to","the","mature","structure",".","The","neural","retina","is","the","part","of","the","retina","that","contains","neurons","and","photoreceptor","cells","."),4033607). assertion_content_comment('tOboGo_RegulationOfNeurogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","neurogenesis",",","the","origin","and","formation","of","neurons","."),3990347). assertion_content_comment('tOboGo_RegulationOfNeurologicalSystemProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","neurophysiological","process",",","an","organ","system","process","carried","out","by","any","of","the","organs","or","tissues","of","neurological","system","."),3988114). assertion_content_comment('tOboGo_RegulationOfNeuronalSynapticPlasticityInResponseToNeurotrophin',s("The","process","in","which","a","neurotrophic","factor","induces","neuronal","synaptic","plasticity",",","the","ability","of","neuronal","synapses","to","change","as","circumstances","require",".","They","may","alter","function",",","such","as","increasing","or","decreasing","their","sensitivity",",","or","they","may","increase","or","decrease","in","actual","numbers","."),4322356). assertion_content_comment('tOboGo_RegulationOfNeuronalSynapticPlasticity',s("A","process","that","modulates","neuronal","synaptic","plasticity",",","the","ability","of","neuronal","synapses","to","change","as","circumstances","require",".","They","may","alter","function",",","such","as","increasing","or","decreasing","their","sensitivity",",","or","they","may","increase","or","decrease","in","actual","numbers","."),4322354). assertion_content_comment('tOboGo_RegulationOfNeuronApoptosis',s("Any","process","that","modulates","the","occurrence","or","rate","of","cell","death","by","apoptosis","in","neurons","."),4064496). assertion_content_comment('tOboGo_RegulationOfNeuronDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","neuron","differentiation","."),4033466). assertion_content_comment('tOboGo_RegulationOfNeuronMaturation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","neuron","maturation",",","the","process","leading","to","the","attainment","of","the","full","functional","capacity","of","a","neuron",".","This","process","is","independent","of","morphogenetic","change","."),4039119). assertion_content_comment('tOboGo_RegulationOfNeuronProjectionDevelopment',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","neuron","projection","development",".","Neuron","projection","development","is","the","process","whose","specific","outcome","is","the","progression","of","a","neuron","projection","over","time",",","from","its","formation","to","the","mature","structure",".","A","neuron","projection","is","any","process","extending","from","a","neural","cell",",","such","as","axons","or","dendrites","(","collectively","called","neurites",")"),4035363). assertion_content_comment('tOboGo_RegulationOfNeuronProjectionRegeneration',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","neuron","projection","regeneration",",","the","regrowth","of","neuronal","processes","such","as","axons","or","dendrites","following","their","loss","or","damage","."),4106741). assertion_content_comment('tOboGo_RegulationOfNeurotransmitterLevels',s("Any","process","that","modulates","levels","of","neurotransmitter","."),3981619). assertion_content_comment('tOboGo_RegulationOfNeurotransmitterSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","neurotransmitter","from","a","cell","or","group","of","cells","."),3988182). assertion_content_comment('tOboGo_RegulationOfNeurotransmitterTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","neurotransmitter","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3988166). assertion_content_comment('tOboGo_RegulationOfNeurotransmitterUptake',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","neurotransmitter","into","a","neuron","or","glial","cell","."),4120339). assertion_content_comment('tOboGo_RegulationOfNeurotrophinProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","a","neurotrophin","."),4064523). assertion_content_comment('tOboGo_RegulationOfNeutrophilAggregation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","neutrophil","aggregation","."),4141723). assertion_content_comment('tOboGo_RegulationOfNeutrophilApoptosis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","neutrophil","apoptosis","."),4065057). assertion_content_comment('tOboGo_RegulationOfNeutrophilChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","neutrophil","chemotaxis",".","Neutrophil","chemotaxis","is","the","directed","movement","of","a","neutrophil","cell",",","the","most","numerous","polymorphonuclear","leukocyte","found","in","the","blood",",","in","response","to","an","external","stimulus",",","usually","an","infection","or","wounding","."),4149813). assertion_content_comment('tOboGo_RegulationOfNeutrophilDegranulation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","neutrophil","degranulation","."),4093608). assertion_content_comment('tOboGo_RegulationOfNeutrophilDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","neutrophil","differentiation","."),4087295). assertion_content_comment('tOboGo_RegulationOfNeutrophilExtravasation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","neutrophil","extravasation","."),4142573). assertion_content_comment('tOboGo_RegulationOfNeutrophilMediatedCytotoxicity',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","neutrophil","mediated","killing","of","a","target","cell",",","the","directed","killing","of","a","target","cell","by","a","neutrophil","."),4131633). assertion_content_comment('tOboGo_RegulationOfNeutrophilMediatedKillingOfBacterium',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","neutrophil","mediated","killing","of","a","bacterium",",","the","directed","killing","of","a","bacterium","by","a","neutrophil","."),4131640). assertion_content_comment('tOboGo_RegulationOfNeutrophilMediatedKillingOfFungus',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","neutrophil","mediated","killing","of","a","fungal","cell",",","the","directed","killing","of","a","fungal","cell","by","a","neutrophil","."),4131784). assertion_content_comment('tOboGo_RegulationOfNeutrophilMediatedKillingOfSymbiontCell',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","neutrophil","mediated","killing","of","a","symbiont","cell",",","the","directed","killing","of","a","symbiont","target","cell","by","a","neutrophil","."),4131637). assertion_content_comment('tOboGo_RegulationOfNFATProteinImportIntoNucleus',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","movement","of","an","NFAT","protein","from","the","cytoplasm","to","the","nucleus","."),4118600). assertion_content_comment('tOboGo_RegulationOfNitrateAssimilation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","uptake",",","from","the","environment",",","of","nitrates",",","inorganic","or","organic","salts","and","esters","of","nitric","acid","and","the","subsequent","reduction","of","nitrate","ion","to","other",",","less","highly","oxidized",",","inorganic","nitrogenous","substances","."),4151127). assertion_content_comment('tOboGo_RegulationOfNitricOxideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","nitric","oxide","."),4089505). assertion_content_comment('tOboGo_RegulationOfNitricOxideMediatedSignalTransduction',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","nitric","oxide","mediated","signal","transduction",".","Nitric","oxide","mediated","signal","transduction","is","a","series","of","molecular","signals","mediated","by","the","detection","of","nitric","oxide","(","NO",")"),4024763). assertion_content_comment('tOboGo_RegulationOfNitricOxideMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nitric","oxide",",","nitrogen","monoxide","(","NO",")",",","a","colorless","gas","only","slightly","soluble","in","water","."),4147748). assertion_content_comment('tOboGo_RegulationOfNitrogenCompoundMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nitrogen","or","nitrogenous","compounds","."),3969115). assertion_content_comment('tOboGo_RegulationOfNitrogenUtilization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","nitrogen","utilization","."),4014305). assertion_content_comment('tOboGo_RegulationOfNKTCellActivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","activation","."),4119386). assertion_content_comment('tOboGo_RegulationOfNKTCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","differentiation","."),4119875). assertion_content_comment('tOboGo_RegulationOfNKTCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","natural","killer","T","cell","proliferation","."),4119811). assertion_content_comment('tOboGo_RegulationOfNorepinephrineSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","norepinephrine","."),4026678). assertion_content_comment('tOboGo_RegulationOfNorepinephrineUptake',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","the","neurotransmitter","norepinephrine","into","a","cell","."),4121500). assertion_content_comment('tOboGo_RegulationOfNotchSignalingPathwayInvolvedInHeartInduction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","series","of","molecular","signals","initiated","by","binding","of","an","extracellular","ligand","to","a","Notch","receptor","on","the","surface","of","the","target","cell","that","contributes","to","heart","induction","."),4084402). assertion_content_comment('tOboGo_RegulationOfNotchSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","Notch","signaling","pathway","."),4019859). assertion_content_comment('tOboGo_RegulationOfNuclearDivision',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","nuclear","division",",","the","partitioning","of","the","nucleus","and","its","genetic","information","."),4012174). assertion_content_comment('tOboGo_RegulationOfNuclearMRNASplicingViaSpliceosome',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mRNA","splicing","via","a","spliceosomal","mechanism","."),3974761). assertion_content_comment('tOboGo_RegulationOfNucleaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","nuclease","activity",",","the","hydrolysis","of","ester","linkages","within","nucleic","acids","."),4013553). assertion_content_comment('tOboGo_RegulationOfNucleobaseNucleosideNucleotideAndNucleicAcidMetabolicProcess',s("Any","cellular","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids","."),3969131). assertion_content_comment('tOboGo_RegulationOfNucleobaseNucleosideNucleotideAndNucleicAcidTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","nucleobases",",","nucleosides",",","nucleotides","and","nucleic","acids",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4025561). assertion_content_comment('tOboGo_RegulationOfNucleocytoplasmicTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","substances","between","the","nucleus","and","the","cytoplasm","."),4016274). assertion_content_comment('tOboGo_RegulationOfNucleosideMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleosides","."),4024221). assertion_content_comment('tOboGo_RegulationOfNucleosideTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","nucleoside","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053751). assertion_content_comment('tOboGo_RegulationOfNucleosomeDensity',s("Any","process","that","modulates","the","number","of","nucleosomes","in","a","given","region","of","a","chromosome","."),4160555). assertion_content_comment('tOboGo_RegulationOfNucleotideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","nucleotides","."),4027587). assertion_content_comment('tOboGo_RegulationOfNucleotideCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","nucleotides","."),4050106). assertion_content_comment('tOboGo_RegulationOfNucleotideMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","nucleotides","."),4010734). assertion_content_comment('tOboGo_RegulationOfNurseCellApoptosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","nurse","cell","apoptosis","."),4088576). assertion_content_comment('tOboGo_RegulationOfOctopamineOrTyramineSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","octopamine","or","tyramine","signaling","pathway","."),4137683). assertion_content_comment('tOboGo_RegulationOfOctopamineSignalingPathwayInvolvedInResponseToFood',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","octopamine","signaling","pathway","involved","in","response","to","food","."),4137692). assertion_content_comment('tOboGo_RegulationOfOctopamineSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","octopamine","signaling","pathway","."),4137688). assertion_content_comment('tOboGo_RegulationOfOdontogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","and","development","of","a","tooth","or","teeth","."),4078536). assertion_content_comment('tOboGo_RegulationOfOlfactoryLearning',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","olfactory","learning",".","Olfactory","learning","is","any","process","in","an","organism","in","which","a","relatively","long-lasting","adaptive","behavioral","change","occurs","in","response","to","(","repeated",")","exposure","to","an","olfactory","cue","."),4150534). assertion_content_comment('tOboGo_RegulationOfOligodendrocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oligodendrocyte","differentiation","."),4107203). assertion_content_comment('tOboGo_RegulationOfOligodendrocyteProgenitorProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oligodendrocyte","progenitor","proliferation","."),4136325). assertion_content_comment('tOboGo_RegulationOfOligopeptideTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","oligopeptides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Oligopeptides","are","molecules","that","contain","a","small","number","(","2","to","20",")","of","amino-acid","residues","connected","by","peptide","linkages","."),4150263). assertion_content_comment('tOboGo_RegulationOfOocyteDevelopment',s("Any","process","that","modulates","the","rate","or","extent","of","the","process","whose","specific","outcome","is","the","progression","of","an","oocyte","over","time",",","from","initial","commitment","of","the","cell","to","its","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4019083). assertion_content_comment('tOboGo_RegulationOfOogoniumDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oogonium","development",",","a","process","that","leads","to","the","formation","of","a","female","gametangium","of","oomycetes",",","containing","one","or","more","gametes","."),4148473). assertion_content_comment('tOboGo_RegulationOfOomyceteSporangiumDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oomycete","sporangium","development",",","a","process","that","leads","to","the","formation","of","oomycete","sporangium",",","a","single-celled","or","many-celled","structure","that","germinates","directly","to","form","an","infection","hypha","or","differentiate",",","through","specialized","cleavage","vesicles",",","into","between","10","and","30","zoospores",",","which","is","laterally","flagellated","."),4147974). assertion_content_comment('tOboGo_RegulationOfOosporeFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oospore","formation",",","a","process","in","which","male","and","female","gametangia","develop","and","fuse","to","form","a","thick-walled","resting","spore","of","oomycetes","."),4148642). assertion_content_comment('tOboGo_RegulationOfOpioidReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","opioid","receptor","signaling","pathway","."),4145421). assertion_content_comment('tOboGo_RegulationOfOpticNerveFormation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","optic","nerve","formation","."),4143861). assertion_content_comment('tOboGo_RegulationOfOrganelleOrganization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","process","involved","in","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","organelle","."),3975627). assertion_content_comment('tOboGo_RegulationOfOrganFormation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","organ","formation",".","Organ","formation","is","the","process","pertaining","to","the","initial","formation","of","an","organ","from","unspecified","parts",".","The","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","discrete","structure",",","such","as","inductive","events",",","and","ends","when","the","structural","rudiment","of","the","organ","is","recognizable",",","such","as","a","condensation","of","mesenchymal","cells","into","the","organ","rudiment","."),3985490). assertion_content_comment('tOboGo_RegulationOfOrganGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","growth","of","an","organ","of","an","organism","."),4087944). assertion_content_comment('tOboGo_RegulationOfOrganicAcidTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","organic","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990663). assertion_content_comment('tOboGo_RegulationOfOrganMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","organ","morphogenesis","."),3985486). assertion_content_comment('tOboGo_RegulationOfOrnithineMetabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","chemical","reactions","and","pathways","involving","ornithine",",","an","amino","acid","only","rarely","found","in","proteins",",","but","which","is","important","in","living","organisms","as","an","intermediate","in","the","reactions","of","the","urea","cycle","and","in","arginine","biosynthesis","."),4139291). assertion_content_comment('tOboGo_RegulationOfOskarMRNATranslation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oskar","mRNA","translation",".","To","ensure","the","localization","of","Oskar","protein","at","the","posterior","pole","of","the","oocyte",",","translation","of","oskar","mRNA","is","repressed","during","its","transport","to","the","posterior","pole","and","activated","upon","localization","of","the","mRNA","at","the","posterior","cortex","."),4235808). assertion_content_comment('tOboGo_RegulationOfOsteoclastDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","osteoclast","differentiation","."),4087423). assertion_content_comment('tOboGo_RegulationOfOvarianFollicleDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ovarian","follicle","development","."),4088182). assertion_content_comment('tOboGo_RegulationOfOviposition',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","deposition","of","eggs",",","either","fertilized","or","not",",","upon","a","surface","or","into","a","medium","."),4099044). assertion_content_comment('tOboGo_RegulationOfOvulation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ovulation",",","the","release","of","a","mature","ovum/oocyte","from","an","ovary","."),4115816). assertion_content_comment('tOboGo_RegulationOfOxidativePhosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","phosphorylation","of","ADP","to","ATP","that","accompanies","the","oxidation","of","a","metabolite","through","the","operation","of","the","respiratory","chain",".","Oxidation","of","compounds","establishes","a","proton","gradient","across","the","membrane",",","providing","the","energy","for","ATP","synthesis","."),3989701). assertion_content_comment('tOboGo_RegulationOfOxidativePhosphorylationUncouplerActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oxidative","phosphorylation","uncoupler","activity","."),4169290). assertion_content_comment('tOboGo_RegulationOfOxidoreductaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oxidoreductase","activity",",","the","catalysis","of","an","oxidation-reduction","(","redox",")","reaction",",","a","reversible","chemical","reaction","in","which","the","oxidation","state","of","an","atom","or","atoms","within","a","molecule","is","altered",".","One","substrate","acts","as","a","hydrogen","or","electron","donor","and","becomes","oxidized",",","while","the","other","acts","as","hydrogen","or","electron","acceptor","and","becomes","reduced","."),4014252). assertion_content_comment('tOboGo_RegulationOfOxygenAndReactiveOxygenSpeciesMetabolicProcess',s("OBSOLETE",".","Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","dioxygen","(","O2",")",",","or","any","of","the","reactive","oxygen","species",",","e.g",".","superoxide","anions","(","O2-",")",",","hydrogen","peroxide","(","H2O2",")",",","and","hydroxyl","radicals","(","-OH",")"),4182120). assertion_content_comment('tOboGo_RegulationOfOxygenMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","oxygen","metabolic","process","."),4143021). assertion_content_comment('tOboGo_RegulationOfPancreaticACellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","pancreatic","A","cell","differentiation","."),4140949). assertion_content_comment('tOboGo_RegulationOfPancreaticJuiceSecretion',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","pancreatic","juice","secretion",",","the","regulated","release","of","pancreatic","juice","by","the","exocrine","pancreas","into","the","upper","part","of","the","intestine","."),4149422). assertion_content_comment('tOboGo_RegulationOfPancreaticStellateCellProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","pancreatic","stellate","cell","proliferation","."),4140592). assertion_content_comment('tOboGo_RegulationOfParaxialMesodermalCellFateDetermination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","paraxial","mesoderm","cell","fate","determination","."),4102738). assertion_content_comment('tOboGo_RegulationOfParaxialMesodermalCellFateSpecification',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","paraxial","mesoderm","cell","fate","specification","."),4102687). assertion_content_comment('tOboGo_RegulationOfPenicillinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","nuclease","activity",",","the","hydrolysis","of","a","penicillin","to","yield","a","substituted","beta-amino","acid","derivative","."),4337918). assertion_content_comment('tOboGo_RegulationOfPenicillinCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","leading","to","the","breakdown","of","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4066758). assertion_content_comment('tOboGo_RegulationOfPenicillinMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","any","antibiotic","that","contains","the","condensed","beta-lactamthiazolidine","ring","system","."),4066739). assertion_content_comment('tOboGo_RegulationOfPenileErection',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","penile","erection",".","Penile","erection","is","the","hardening",",","enlarging","and","rising","of","the","penis","which","often","occurs","in","the","sexually","aroused","male","and","enables","sexual","intercourse",".","Achieved","by","increased","inflow","of","blood","into","the","vessels","of","erectile","tissue",",","and","decreased","outflow","."),4117432). assertion_content_comment('tOboGo_RegulationOfPeptidaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","peptidase","activity",",","the","hydrolysis","of","peptide","bonds","within","proteins","."),4011536). assertion_content_comment('tOboGo_RegulationOfPeptideHormoneProcessing',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","peptide","hormone","processing",".","Peptide","hormone","processing","is","the","generation","of","a","mature","peptide","hormone","by","posttranslational","processing","of","a","prohormone","."),4117161). assertion_content_comment('tOboGo_RegulationOfPeptideHormoneSecretion',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","regulated","release","of","a","peptide","hormone","from","secretory","granules","."),4057070). assertion_content_comment('tOboGo_RegulationOfPeptideSecretion',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","peptide","secretion","."),3997288). assertion_content_comment('tOboGo_RegulationOfPeptideTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","peptides",",","compounds","of","two","or","more","amino","acids","where","the","alpha","carboxyl","group","of","one","is","bound","to","the","alpha","amino","group","of","another",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3997285). assertion_content_comment('tOboGo_RegulationOfPeptidoglycanRecognitionProteinSignalingPathway',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","peptidoglycan","recognition","protein","signaling","pathway","."),4113649). assertion_content_comment('tOboGo_RegulationOfPeripheralBCellAnergy',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","peripheral","B","cell","anergy","."),3999706). assertion_content_comment('tOboGo_RegulationOfPeripheralBCellDeletion',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","peripheral","B","cell","deletion","."),3999819). assertion_content_comment('tOboGo_RegulationOfPeripheralTCellToleranceInduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","peripheral","T","cell","tolerance","induction","."),4000348). assertion_content_comment('tOboGo_RegulationOfPeripheralToleranceInduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","peripheral","tolerance","induction","."),3995266). assertion_content_comment('tOboGo_RegulationOfPeroxidaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","peroxidase","activity","."),4171832). assertion_content_comment('tOboGo_RegulationOfPeroxisomeProliferatorActivatedReceptorSignalingPathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","peroxisome","proliferator","activated","receptor","signaling","pathway","."),4083374). assertion_content_comment('tOboGo_RegulationOfPhagocytosisEngulfment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","internalization","of","bacteria",",","immune","complexes","and","other","particulate","matter","or","of","an","apoptotic","cell","by","phagocytosis","."),4108759). assertion_content_comment('tOboGo_RegulationOfPhagocytosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phagocytosis",",","the","process","in","which","phagocytes","engulf","external","particulate","material","."),4101023). assertion_content_comment('tOboGo_RegulationOfPharyngealPumping',s("Any","process","that","modulates","the","contraction","and","relaxation","movements","of","the","pharyngeal","muscle","that","mediates","feeding","in","nematodes","."),4094182). assertion_content_comment('tOboGo_RegulationOfPhialideDevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phialide","development",",","a","process","that","leads","to","the","formation","of","phialides",".","Phialides","are","specialized","cells","that","bud","from","the","ends","of","metulae","on","the","conidiophore","tip","."),4132407). assertion_content_comment('tOboGo_RegulationOfPhosphataseActivity',s("Any","process","that","modulates","the","rate","or","frequency","of","phosphatase","activity",".","Phosphatases","catalyze","the","hydrolysis","of","phosphoric","monoesters",",","releasing","inorganic","phosphate","."),4160736). assertion_content_comment('tOboGo_RegulationOfPhosphateMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","phosphates","."),3972454). assertion_content_comment('tOboGo_RegulationOfPhosphateTransmembraneTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phosphate","transmembrane","transport","."),4141312). assertion_content_comment('tOboGo_RegulationOfPhosphateTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phosphate","transport",".","Phosphate","transport","is","the","directed","movement","of","phosphate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4035683). assertion_content_comment('tOboGo_RegulationOfPhosphatidylcholineCatabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","phosphatidylcholine","catabolism",".","Phosphatidylcholine","catabolic","processes","are","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phosphatidylcholines",",","any","of","a","class","of","glycerophospholipids","in","which","the","phosphatidyl","group","is","esterified","to","the","hydroxyl","group","of","choline","."),4037961). assertion_content_comment('tOboGo_RegulationOfPhosphatidylinositolBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phosphatidylinositol","."),4030283). assertion_content_comment('tOboGo_RegulationOfPhosphatidylinositolDephosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reaction","involving","the","removal","of","one","or","more","phosphate","groups","from","a","phosphatidylinositol","."),4115774). assertion_content_comment('tOboGo_RegulationOfPhospholipaseA2Activity',s("Any","process","that","modulates","the","activity","of","the","enzyme","phospholipase","A2","."),4318015). assertion_content_comment('tOboGo_RegulationOfPhospholipaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phospholipase","activity",",","the","hydrolysis","of","a","phospholipid","."),4049027). assertion_content_comment('tOboGo_RegulationOfPhospholipidBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phospholipids","."),4030276). assertion_content_comment('tOboGo_RegulationOfPhospholipidCatabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","phospholipid","catabolism",",","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phospholipids",",","any","lipid","containing","phosphoric","acid","as","a","mono-","or","diester","."),4037958). assertion_content_comment('tOboGo_RegulationOfPhospholipidTranslocation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","translocation",",","or","flipping",",","of","phospholipid","molecules","from","one","monolayer","of","a","membrane","bilayer","to","the","opposite","monolayer","."),4135401). assertion_content_comment('tOboGo_RegulationOfPhosphoproteinPhosphataseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phosphoprotein","phosphatase","activity",",","the","catalysis","of","the","hydrolysis","of","phosphate","from","a","phosphoprotein","."),4181095). assertion_content_comment('tOboGo_RegulationOfPhosphorusMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","phosphorus","or","compounds","containing","phosphorus","."),3972450). assertion_content_comment('tOboGo_RegulationOfPhosphorusUtilization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phosphorus","utilization","."),4014605). assertion_content_comment('tOboGo_RegulationOfPhosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","addition","of","phosphate","groups","into","a","molecule","."),3972458). assertion_content_comment('tOboGo_RegulationOfPhotomorphogenesis',s("Any","process","that","modulates","the","rate","or","extent","of","photomorphogenesis","."),4033030). assertion_content_comment('tOboGo_RegulationOfPhotoperiodismFlowering',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","photoperiodism",",","flowering","."),4106282). assertion_content_comment('tOboGo_RegulationOfPhotoreceptorCellAxonGuidance',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","photoreceptor","cell","axon","guidance","."),4139817). assertion_content_comment('tOboGo_RegulationOfPhotoreceptorCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","photoreceptor","cell","differentiation",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4033595). assertion_content_comment('tOboGo_RegulationOfPhotorespiration',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","photorespiration",".","Photorespiration","is","a","light-dependent","catabolic","process","occurring","concomitantly","with","photosynthesis","in","plants","(","especially","C3","plants",")","whereby","dioxygen","(","O2",")","is","consumed","and","carbon","dioxide","(","CO2",")","is","evolved","."),4147606). assertion_content_comment('tOboGo_RegulationOfPhotosynthesisDarkReaction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","photosynthesis","dark","reaction","."),4033070). assertion_content_comment('tOboGo_RegulationOfPhotosynthesisLightReaction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","light-dependent","reaction","of","photosynthesis","."),4031606). assertion_content_comment('tOboGo_RegulationOfPhotosynthesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","photosynthesis","."),4031602). assertion_content_comment('tOboGo_RegulationOfPH',s("Any","process","involved","in","the","maintenance","of","an","internal","equilibrium","of","hydrogen","ions",",","thereby","modulating","the","internal","pH",",","within","an","organism","or","cell","."),4069967). assertion_content_comment('tOboGo_RegulationOfPhytoalexinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phytoalexin","biosynthesis",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytoalexins","."),4110337). assertion_content_comment('tOboGo_RegulationOfPhytoalexinMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phytoalexin","metabolism",",","the","chemical","reactions","and","pathways","involving","phytoalexins",",","any","of","a","range","of","substances","produced","by","plants","as","part","of","their","defense","response","."),4110333). assertion_content_comment('tOboGo_RegulationOfPigmentCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","pigmented","cell","differentiation","."),4086924). assertion_content_comment('tOboGo_RegulationOfPinocytosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","pinocytosis",".","Pinocytosis","is","the","process","in","which","cells","take","in","liquid","material","from","their","external","environment",";","literally","'","cell","drinking","'","Liquid","is","enclosed","in","vesicles",",","formed","by","invagination","of","the","plasma","membrane",".","These","vesicles","then","move","into","the","cell","and","pass","their","contents","to","endosomes","."),4102944). assertion_content_comment('tOboGo_RegulationOfPlanarCellPolarityPathwayInvolvedInAxisElongation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","axis","elongation","."),4139050). assertion_content_comment('tOboGo_RegulationOfPlanarCellPolarityPathwayInvolvedInCardiacMuscleTissueMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","cardiac","muscle","tissue","morphogenesis","."),4137884). assertion_content_comment('tOboGo_RegulationOfPlanarCellPolarityPathwayInvolvedInCardiacRightAtriumMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","cardiac","right","atrium","morphogenesis","."),4141503). assertion_content_comment('tOboGo_RegulationOfPlanarCellPolarityPathwayInvolvedInHeartMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","heart","morphogenesis","."),4137863). assertion_content_comment('tOboGo_RegulationOfPlanarCellPolarityPathwayInvolvedInNeuralTubeClosure',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","neural","tube","closure","."),4141660). assertion_content_comment('tOboGo_RegulationOfPlanarCellPolarityPathwayInvolvedInOutflowTractMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","outflow","tract","morphogenesis","."),4141482). assertion_content_comment('tOboGo_RegulationOfPlanarCellPolarityPathwayInvolvedInPericardiumMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","pericardium","morphogenesis","."),4141682). assertion_content_comment('tOboGo_RegulationOfPlanarCellPolarityPathwayInvolvedInVentricularSeptumMorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","planar","cell","polarity","pathway","involved","in","ventricular","septum","morphogenesis","."),4137866). assertion_content_comment('tOboGo_RegulationOfPlasmacytoidDendriticCellAntigenProcessingAndPresentation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","plasmacytoid","dendritic","cell","antigen","processing","and","presentation","."),3994675). assertion_content_comment('tOboGo_RegulationOfPlasmacytoidDendriticCellCytokineProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","plasmacytoid","dendritic","cell","cytokine","production","."),3997205). assertion_content_comment('tOboGo_RegulationOfPlasmaLipoproteinParticleLevels',s("Any","process","involved","in","the","maintenance","of","internal","levels","of","plasma","lipoprotein","particles","within","an","organism","."),4035706). assertion_content_comment('tOboGo_RegulationOfPlasmaLipoproteinParticleOxidation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","lipoprotein","oxidation",",","occurring","in","the","blood","plasma","."),4074932). assertion_content_comment('tOboGo_RegulationOfPlasmaMembraneSterolDistribution',s("Any","process","that","modulates","the","proportions","or","spatial","arrangement","of","sterols","in","the","plasma","membrane","."),4074214). assertion_content_comment('tOboGo_RegulationOfPlasmatocyteDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","plasmatocyte","differentiation","."),4087206). assertion_content_comment('tOboGo_RegulationOfPlasminogenActivation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","plasminogen","activation",".","Plasminogen","activation","is","the","process","in","which","plasminogen","is","processed","to","plasmin","."),4024894). assertion_content_comment('tOboGo_RegulationOfPlateletActivation',s("Any","process","that","modulates","the","rate","or","frequency","of","platelet","activation",".","Platelet","activation","is","a","series","of","progressive",",","overlapping","events","triggered","by","exposure","of","the","platelets","to","subendothelial","tissue","."),4027074). assertion_content_comment('tOboGo_RegulationOfPlateletAggregation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","platelet","aggregation",".","Platelet","aggregation","is","the","adhesion","of","one","platelet","to","one","or","more","other","platelets","via","adhesion","molecules","."),4150605). assertion_content_comment('tOboGo_RegulationOfPodosomeAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","podosome","assembly","."),4129424). assertion_content_comment('tOboGo_RegulationOfPolarizedEpithelialCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","polarized","epithelial","cell","differentiation","."),4061784). assertion_content_comment('tOboGo_RegulationOfPolePlasmOskarMRNALocalization',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","process","in","which","oskar","mRNA","is","transported","to",",","or","maintained","in",",","the","oocyte","pole","plasm","."),4019087). assertion_content_comment('tOboGo_RegulationOfPollenTubeGrowth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","pollen","tube","growth","."),4147596). assertion_content_comment('tOboGo_RegulationOfPolyamineBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","polyamine","biosynthesis",".","Polyamine","biosynthesis","is","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","polyamines",",","any","organic","compound","containing","two","or","more","amino","groups","."),4035587). assertion_content_comment('tOboGo_RegulationOfPolysaccharideBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","polysaccharides","."),4009153). assertion_content_comment('tOboGo_RegulationOfPolysaccharideMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","polysaccharides","."),4009000). assertion_content_comment('tOboGo_RegulationOfPositiveChemotaxis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","in","a","concentration","gradient","of","a","specific","chemical","."),4099996). assertion_content_comment('tOboGo_RegulationOfPositiveChemotaxisToCAMPByChlorinatedAlkylphenone',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","by","the","action","of","a","chlorinated","alkylphenone",".","An","alkylphenone","is","an","aromatic","polyketide","with","methyl","and","chlorine","substitutions","."),4156072). assertion_content_comment('tOboGo_RegulationOfPositiveChemotaxisToCAMP',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","."),4135484). assertion_content_comment('tOboGo_RegulationOfPostsynapticMembranePotential',s("Any","process","that","modulates","the","establishment","or","extent","of","the","postsynaptic","membrane","potential",",","which","is","generated","by","changes","in","the","membrane","potential","of","the","post","synaptic","neuron","that","receives","information","at","a","synapse",".","The","presynaptic","neuron","releases","neurotransmitters","into","the","synaptic","cleft","which","bind","to","receptors","on","the","postsynaptic","neuron",".","After","being","bound","by","the","neurotransmitters",",","these","receptors","can","open","or","close","an","ion","channel",",","allowing","ions","to","enter","or","leave","the","cell","and","therefore","altering","the","membrane","potential","of","the","postsynaptic","neuron","."),4038728). assertion_content_comment('tOboGo_RegulationOfPosttranscriptionalGeneSilencing',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","inactivation","of","gene","expression","by","a","posttranscriptional","mechanism","."),4108236). assertion_content_comment('tOboGo_RegulationOfPotassiumIonTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","potassium","ions","(","K","+",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4093234). assertion_content_comment('tOboGo_RegulationOfPreblastodermMitoticCellCycle',s("A","cell","cycle","process","that","modulates","the","rate","or","extent","of","the","progression","through","the","preblastoderm","mitotic","cell","cycle","."),4019149). assertion_content_comment('tOboGo_RegulationOfPrimaryHeartFieldCardioblastProliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cardioblast","proliferation","in","the","first","heart","field",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4194301). assertion_content_comment('tOboGo_RegulationOfPrimaryMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","within","a","cell","or","an","organism","involving","those","compounds","formed","as","a","part","of","the","normal","anabolic","and","catabolic","processes",".","These","processes","take","place","in","most",",","if","not","all",",","cells","of","the","organism","."),3969128). assertion_content_comment('tOboGo_RegulationOfPrimaryMicroRNAProcessing',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","primary","microRNA","processing","."),4143888). assertion_content_comment('tOboGo_RegulationOfPrimitiveErythrocyteDifferentiation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","primitive","erythrocyte","differentiation",".","Primitive","erythrocyte","differentiation","occurs","as","part","of","the","process","of","primitive","hemopoiesis","."),4024405). assertion_content_comment('tOboGo_RegulationOfProanthocyanidinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","proanthocyanidin","biosynthetic","process","."),4139516). assertion_content_comment('tOboGo_RegulationOfProductionOfMolecularMediatorOfImmuneResponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","production","of","molecular","mediator","of","immune","response","."),3993314). assertion_content_comment('tOboGo_RegulationOfProductionOfSiRNAInvolvedInChromatinSilencingBySmallRNA',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","production","of","siRNA",",","the","cleavage","of","double-stranded","RNA","to","form","small","interfering","RNA","molecules","(","siRNAs",")","of","21-23","nucleotides",",","in","the","context","of","chromatin","silencing","by","small","RNA","."),4131935). assertion_content_comment('tOboGo_RegulationOfProductionOfSiRNAInvolvedInRNAInterference',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","production","of","siRNA",",","the","cleavage","of","double-stranded","RNA","to","form","small","interfering","RNA","molecules","(","siRNAs",")","of","21-23","nucleotides",",","in","the","context","of","RNA","interference","."),4150041). assertion_content_comment('tOboGo_RegulationOfProductionOfSmallRNAInvolvedInGeneSilencingByRNA',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","production","of","small","RNA","involved","in","gene","silencing","by","RNA","."),4131930). assertion_content_comment('tOboGo_RegulationOfProgesteroneBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","progesterone","biosynthetic","process","."),4133625). assertion_content_comment('tOboGo_RegulationOfProgrammedCellDeath',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","programmed","cell","death",",","cell","death","resulting","from","activation","of","endogenous","cellular","processes","."),3983066). assertion_content_comment('tOboGo_RegulationOfProlineMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","proline","metabolic","process","."),4140734). assertion_content_comment('tOboGo_RegulationOfProlineTransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","proline","transport","."),4132055). assertion_content_comment('tOboGo_RegulationOfPronephrosSize',s("Any","process","that","modulates","the","size","of","a","pronephric","kidney","."),4082314). assertion_content_comment('tOboGo_RegulationOfProstaglandinBiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","prostaglandin","."),4058481). assertion_content_comment('tOboGo_RegulationOfProstaglandinSecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","a","prostaglandin","from","a","cell","or","group","of","cells","."),4054711). assertion_content_comment('tOboGo_RegulationOfProstaticBudFormation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","prostatic","bud","formation",",","the","morphogenetic","process","in","which","a","region","of","the","fetal","urogenital","sinus","epithelium","is","specified","to","become","the","prostate",",","resulting","in","prostate","bud","outgrowth","."),4112289). assertion_content_comment('tOboGo_RegulationOfProstheticGroupMetabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","a","prosthetic","group","."),4119599). assertion_content_comment('tOboGo_RegulationOfProteasomalProteinCatabolicProcess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds","that","is","mediated","by","the","proteasome","."),4012127). assertion_content_comment('tOboGo_RegulationOfProteasomeAssembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","aggregation",",","arrangement","and","bonding","together","of","a","mature",",","active","proteasome","complex","."),4150924). assertion_content_comment('tOboGo_RegulationOfProteasomeCoreComplexAssembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","aggregation",",","arrangement","and","bonding","together","of","a","mature",",","active","20S","proteasome","core","particle","complex","that","does","not","contain","any","regulatory","particles","."),4150927). assertion_content_comment('tOboGo_RegulationOfProteinActivationCascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","activation","cascade","."),3986250). assertion_content_comment('tOboGo_RegulationOfProteinAutophosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","addition","of","the","phosphorylation","by","a","protein","of","one","or","more","of","its","own","residues","."),4057336). assertion_content_comment('tOboGo_RegulationOfProteinBinding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","binding","."),4154933). assertion_content_comment('tOboGo_RegulationOfProteinCatabolicProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","by","the","destruction","of","the","native",",","active","configuration",",","with","or","without","the","hydrolysis","of","peptide","bonds","."),3995709). assertion_content_comment('tOboGo_RegulationOfProteinComplexAssembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","complex","assembly","."),3988827). assertion_content_comment('tOboGo_RegulationOfProteinComplexDisassembly',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","complex","disassembly",",","the","disaggregation","of","a","protein","complex","into","its","constituent","components","."),4009620). assertion_content_comment('tOboGo_RegulationOfProteinDeacetylation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","protein","deacetylation",",","the","removal","of","an","acetyl","group","from","a","protein","amino","acid",".","An","acetyl","group","is","CH3CO-",",","derived","from","acetic","[","ethanoic","]","acid","."),4062772). assertion_content_comment('tOboGo_RegulationOfProteinDeneddylation',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","protein","deneddylation",",","the","removal","of","a","ubiquitin-like","protein","of","the","NEDD8","type","from","a","protein","."),4111389). assertion_content_comment('tOboGo_RegulationOfProteinDephosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","removal","of","phosphate","groups","from","a","protein","."),4071151). assertion_content_comment('tOboGo_RegulationOfProteinDesumoylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","desumoylation",".","Protein","desumoylation","is","the","process","in","which","a","SUMO","protein","(","small","ubiquitin-related","modifier",")","is","cleaved","from","its","target","protein","."),4115528). assertion_content_comment('tOboGo_RegulationOfProteinDeubiquitination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","deubiquitination",".","Protein","deubiquitination","is","the","removal","of","one","or","more","ubiquitin","groups","from","a","protein","."),4150284). assertion_content_comment('tOboGo_RegulationOfProteinExitFromEndoplasmicReticulum',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","proteins","from","the","endoplasmic","reticulum","."),4132225).