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assertion_content_comment('tObjectTympani',s("large","orchestral","drum",";","also","kettle","drum"),1100803).
assertion_content_comment('tObjectType43SupportWatercraft',s("A","class","|","|","of","support","watercraft","currently","(","2000",")","|","|","used","by","#$","China-PeoplesRepublic","."),581505).
assertion_content_comment('tObjectType90ArmoredFightingVehicle',s("Class","of","|","|","#$","ArmoredFightingVehicle","currently","(","2000",")","used","by","#$","China-PeoplesRepublic","."),568137).
assertion_content_comment('tObjectTypewriter',s("The","collection","of","all","typewriter","machines",".","A","type","of","#$","BusinessMachine","and","#$","HumanOccupationConstructObject",".","The","collection","#$","Typewriter","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3006688).
assertion_content_comment('tObjectUAVCamera',s("The","collection","of","all","cameras","carried","by","instances","of","#$","UnmannedAerialVehicle","."),4604348).
assertion_content_comment('tObjectUltracentrifuge',s("A","specialization","of","#$","Centrifuge",".","Ultracentrifuges","are","extremely","powerful","centrifuges","that","can","apply","forces","of","over","one","million","times","the","force","of","gravity","."),3859628).
assertion_content_comment('tObjectUltralightAirplane',s("The","collection","of","#$","Ultralight","vehicles","in","the","shape","of","an","airplane","."),1098761).
assertion_content_comment('tObjectUltralightHelicopter',s("The","collection","of","#$","Ultralight","vehicles","in","the","shape","of","a","helicopter","."),1098998).
assertion_content_comment('tObjectUltralight',s("The","collection","of","slow","light","single","seat","powered","flying","machines","[","#$","AirTransportationDevice","]","No","pilot","'","s","license","is","required","to","fly","one",",","but","there","are","restrictions","for","use",",","such","as","not","flying","at","night",",","not","in","clouds",",","not","over","town/settlements",",","not","near","airports",",","Unpowered","ultralight","vehicles","as","defined","by","the","US","government","are","not","included","."),1098525).
assertion_content_comment('tObjectUltrasoundScanner',s("Devices","which","are","used","to","image","internal","body","structures",".","They","emit","ultrasound","which","is","reflected","from","the","object","being","scanned",".","The","scanner","receives","the","reflected","ultrasound","and","forms","an","image","."),1100690).
assertion_content_comment('tObjectUmbrella',s("A","mechanical","device","used","for","protection","against","certain","elements","of","nature"),1102214).
assertion_content_comment('tObjectUmbrellaUsedAsCovering',s("A","subAbstractionType","of","umbrella",",","being","used","as","a","covering","to","protect","the","user","against","elements","of","nature"),1102452).
assertion_content_comment('tObjectUnderConstructionExistentialStatus',s("This","instance","of","#$","ConstructionArtifactTypeByExistentialStatus","describes","|","|","instances","of","#$","ConstructionArtifact","that","are","under","construction",".","Things","|","|","with","this","attribute","do","not","yet","have","the","attribute","|","|","$","Operational-ConstructionAttribute","."),1195704).
assertion_content_comment('tObjectUnderneathWhichAHumanCanMovePast',s("A","specialization","of","#$","EnduringThing-Localized","(","q.v.",")","Each","instance","|","of","#$","ObjectUnderneathWhichAHumanCanMovePast","is","a","tangible","object","underneath","which","a","typical","#$","HumanAdult","can",",","unaided","by","technology",",","move","past","by","walking",",","crawling","or","slithering","if","need","be","(","see","#$","MovingPastSomethingUnderneathIt",")"),2743253).
assertion_content_comment('tObjectUnderpants',s("The","collection","of","#$","Underwear",",","for","either","men","or","women",",","that","is","worn","on","the","lower","part","of","the","body",",","with","separate","openings","for","each","#$","Leg","."),1106987).
assertion_content_comment('tObjectUndershirtSleeveless',s("The","collection","of","sleeveless","undershirts",".","This","is","the","kind","of","undershirt","that","is","also","called","a","tank","top","in","some","parts","of","the","country",",","or","a","Guinea","T","in","New","Jersey","."),1109314).
assertion_content_comment('tObjectUndershirt',s("The","collection","of","undershirts","--","both","tank","tops","[","#$","Undershirt-Sleeveless","]","and","T-shirts","designed","as","underwear","."),1109242).
assertion_content_comment('tObjectUnderstatedClothingStyle',s("The","collection","of","instances","of","#$","SomethingToWear","that","present","an","\"","understated","\"","image","."),1195521).
assertion_content_comment('tObjectUnderwaterCamera',s("The","collection","of","cameras","which","can","be","used","|","|","underwater","."),1104947).
assertion_content_comment('tObjectUnderwayReplenishmentShip',s("The","collection","of","ships","intended","to","be","used","to","transport","materiel","to","other","ships","which","are","engaged","in","some","kind","of","operation","."),1074242).
assertion_content_comment('tObjectUnderwear',s("The","collection","of","all","undergarments"),1051492).
assertion_content_comment('tObjectUndividedPathArtifact',s("#$","Undivided-PathArtifact","is","the","collection","of","roads","that","are","|","|","without","median",",","i.e",".","they","don","'","t","have","divided","roadbeds","."),1193477).
assertion_content_comment('tObjectUnfilledDonut',s("The","collection","of","all","#$","Doughnuts","with","no","fillings","."),1322482).
assertion_content_comment('tObjectUnfinishedGarment',s("A","specialization","of","#$","Garment",".","Each","instance","of","#$","UnfinishedGarment","is","a","#$","Garment","in","the","process","of","being","constructed",".","Therefore",",","it","may","have","physical","parts","that","are","not","connected","to","the","whole","."),4757177).
assertion_content_comment('tObjectUnfinishedWoodenFurniture',s("This","is","the","collection","of","instances","of","#$","FurniturePiece","which","are","made","of","wood","and","which","are","devoid","of","#$","Finish",".","Some","stores","sell","furniture","in","this","state","for","customers","to","purchase","and","complete","by","sanding","and","finishing",";","other","instances","of","this","collection","are","an","intermediate","step","in","the","making","of","a","completed","piece","of","furniture","."),4752482).
assertion_content_comment('tObjectUnicycle',s("The","collection","of","all","unicycles",",","which","are","person-powered","wheeled","vehicles","with","only","one","wheel","(","by","design",")","A","type","of","#$","SinglePassengerTransportationDevice",",","#$","ManufacturedGoods",",","#$","Device-UserControlled",",","#$","WheeledTransportationDevice",",","#$","Device-UserPowered",",","and","#$","MountableTransporter",".","The","collection","#$","Unicycle","is","a","#$","TransportationDeviceType",",","a","#$","SpatiallyDisjointObjectType",",","an","#$","ArtifactTypeByGenericCategory",",","and","a","#$","ManufacturedGoodsType","."),3006999).
assertion_content_comment('tObjectUnimprovedSurfacePathArtifact',s("This","is","the","collection","of","instances","of","#$","PathArtifact","that","can","|","|","accomodate","only","light","loads","in","dry","weather",".","They","are","without","surface","|","|","improvement","and","are","seldom","maintained",".","Included","are","abandoned","roads",",","fire","|","|","roads",",","and","lumber","roads",".","Source",":","US","Army","Field","Manual",",","FM","21-31","."),1192087).
assertion_content_comment('tObjectUninterruptiblePowerSupply',s("A","specialization","of","#$","ElectricalComponent",".","Each","instance","of","#$","UninterruptiblePowerSupply","ia","a","device","that","maintains","continuously","supplied","battery-backup","power","to","connected","devices","when","main","utility","power","becomes","unavailable","."),3130907).
assertion_content_comment('tObjectUnitedStatesMilitaryWeapon',s("The","collection","of","weapon","models","that","have","been",",","at","one","time","or","another",",","adopted","for","use","by","the","military","of","the","United","States","."),3241275).
assertion_content_comment('tObjectUnixAccountSystem',s("The","collection","of","instances","of","#$","AccountSystem","that","are","|","built","around","the","#$","UnixOS","."),1105072).
assertion_content_comment('tObjectUNIXMachine',s("The","collection","of","all","#$","Computers","that","run","some","version","of","#$","UnixOS","(","e.g",".","#$","Linux",",","Solaris...",")"),1257325).
assertion_content_comment('tObjectUnmannedAerialVehicleReconnaissance',s("A","collection","of","unmanned","aircraft","used","for","reconnaissance","|","purposes",".","UAVs","generally","carry","some","kind","of","camera","or","sensing","|","device","."),835586).
assertion_content_comment('tObjectUnmannedAerialVehicle',s("The","collection","of","UAVs",",","A","specialization","of","#$","UnmannedAircraft","with","a","precise","military","definition",".","Unlike","#$","UnmannedAircraft","generally",",","certain","kinds","of","missiles","(","e.g.",",","cruise","missile",",","ballistic","or","semiballictic","missiles",")","do","not","count","as","UAVs",".","Typically",",","an","instance","of","#$","UnmannedAircraft","counts","as","a","UAV","if","it","is","powered",",","can","fly","autonomously","or","by","remote","control",",","and","can","carry","a","payload","."),1451093).
assertion_content_comment('tObjectUnmannedAircraft',s("The","collection","of","#$","AirTransportationDevices","which","are","designed","to","travel","without","human","#$","driverActor",".","These","craft","may","be","steered","by","remote","control","."),1073710).
assertion_content_comment('tObjectUnmannedCrewAttribute',s("The","collection","of","all","'","unmanned","'","#$","TransportationDevices",",","i.e.",",","all","#$","TransportationDevices","for","which","no","assigned","'","crew","'","is","physically","present","'","on","'","the","device","."),2836926).
assertion_content_comment('tObjectUnpavedPathArtifact',s("This","is","the","collection","of","unpaved","instances","of","#$","PathArtifact",",","i.e",".","the","opposite","collection","(","see","#$","oppositeCollections",")","of","#$","PavedPath",".","See","its","two","main","specializations",":","#$","UnimprovedSurface-PathArtifact","and","#$","ImprovedSurface-PathArtifact","."),2796513).
assertion_content_comment('tObjectUnseparatedPathArtifact',s("#$","Unseparated-PathArtifact","is","the","collection","of","roads","that","are","either","|","|","without","median","or","have","their","divided","roadbeds","separated","by","a","distance","|","|","smaller","than","75","meters","."),1191197).
assertion_content_comment('tObjectUnseparatedPathArtifact',s("This","criterion","belongs","to","the","US","Army","'","s","nomenclature","for","|","roads","-","MIL-STD-2408","code","1P030","SEP","001","."),1191191).
assertion_content_comment('tObjectUnunbium',s("A","collection","of","pieces","of","material",".","Each","piece","is","#$","RadioactiveStuff",";","typically",",","|","these","will","be","tightly","bound","into","solid","form","."),1112826).
assertion_content_comment('tObjectUnunnilium',s("A","collection","of","pieces","of","material",".","Each","piece","is","a","RadioactiveObject","of","#$","Ununnilium",";","typically",",","these","will","be","tightly","bound","into","solid","form","."),1074862).
assertion_content_comment('tObjectUnununium',s("A","collection","of","pieces","of","material",".","Each","piece","is","#$","RadioactiveStuff",";","typically",",","|","these","will","be","tightly","bound","into","solid","form","."),1112807).
assertion_content_comment('tObjectUprightPiano',s("Collection","of","all","instances","of","#$","Piano-Acoustic","in","which","the","frame","on","which","the","piano","strings","are","strung","is","vertical","."),1064606).
assertion_content_comment('tObjectUprightVacuumCleaner',s("The","set","of","all","upright","type","vacuum","cleaners","."),1099212).
assertion_content_comment('tObjectUraniumFuelPellet',s("The","collection","of","uranium","fuel","pellets","--","fuel","used","in","nuclear","power","plants",".","Unlike","conventional","fuels",",","the","pellets","are","not","burned","to","create","heat","or","exhaust","gasses","which","power","turbines",".","Instead","a","controlled","fission","process","is","initiated","which","then","heats","water","into","steam","that","powers","turbines","."),5284930).
assertion_content_comment('tObjectUrinal',s("Toilets","for","male","urination","while","standing"),1103109).
assertion_content_comment('tObjectUrn',s("The","collection","of","all","urns",".","A","type","of","#$","ContainerArtifact",".","#$","Urn","is","a","#$","SpatiallyDisjointObjectType","."),3010322).
assertion_content_comment('tObjectUrutuChassisBasedVehicle',s("The","collection","of","all","vehicles","based","on","the","Urutu","chassis",".","A","type","of","#$","WheeledVehicle-Armored",",","#$","RoadVehicle",",","#$","MilitaryVehicle",",","and","#$","MilitaryLandPlatform",".","The","collection","#$","UrutuChassisBasedVehicle","is","a","#$","RoadVehicleByChassisType","and","a","#$","SpatiallyDisjointObjectType","."),3007019).
assertion_content_comment('tObjectUSBAuthenticationDevice',s("A","collection","of","plug-in","USB","devices","that","perform","authentication","functions",".","These","devices","plug","into","the","USB","port","of","a","computer","or","other","electronic","device","and","provide","a","unique","key","or","serial","number","that","allows","the","user","to","perform","some","function","of","the","device",".","This","collection","includes","USB","Keys","that","are","intended","to","provide","copy","protection","for","#$","ComputerProgramCopys","as","well","as","keys","that","work","with","software","to","perform","other","sorts","of","authentication","functions","such","as","digitally","signing","software","or","documents","or","encrypting","files","."),3751448).
assertion_content_comment('tObjectUSBComputerCable',s("The","collection","of","computer","cable","|","|","used","to","connect","USB","(","Universal","Serial","Bus",")","devices","."),1105063).
assertion_content_comment('tObjectUsedArtifact',s("Used","as","an","attribute","of","a","product","to","indicate","it","'","s","used","."),1187615).
assertion_content_comment('tObjectUsedAutomobile',s("A","fuel-burning","mechanical","device","which","is","a","conveyance",",","for","ground","transportation","-","in","short","`","a","used","car","'"),1102956).
assertion_content_comment('tObjectUserTriggeredWeapon',s("An","#$","ExistingObjectType","and","specialization","of","#$","TriggerableDevice",".","Each","instance","of","#$","UserTriggeredWeapon","is","a","#$","Weapon",",","such","as","a","#$","Gun","or","#$","RemoteControlledBomb",",","that","is","intended","to","be","triggered","by","its","user",",","at","the","user","'","s","discretion",".","This","is","to","be","contrasted","with","a","#$","ProximityTriggeredWeapon",",","such","as","a","#$","LandMine",",","that","is","intended","to","be","triggered","accidentally","by","an","enemy","."),2610867).
assertion_content_comment('tObjectUSMilitaryChemicalProtectiveMask',s("The","class","of","all","#$","ProtectiveFiltrationMasks","manufactured","by","|","|","the","US","Army","during","the","last","decade","of","the","20th","century","and","the","first","|","|","decade","of","the","21st",",","and","issued","to","US","Army","personnel","for","field","use","."),1071423).
assertion_content_comment('tObjectVacuumCleanerCompact',s("The","collection","of","all","dustbusters",".","A","type","of","#$","VacuumCleaner",".","The","collection","#$","VacuumCleaner-Compact","is","a","#$","ManufacturedGoodsType",",","a","#$","SpatiallyDisjointObjectType",",","and","an","#$","ArtifactTypeByGenericCategory","."),3008493).
assertion_content_comment('tObjectVacuumCleaner',s("The","collection","of","all","vacuum","cleaners",".","A","type","of","#$","DomesticCleaningTool",",","#$","ManufacturedGoods",",","and","#$","ElectricalHouseholdAppliance",".","The","concept","#$","VacuumCleaner","is","a","#$","DeviceTypeByFunction","."),3314517).
assertion_content_comment('tObjectVacuumDustBag',s("The","collection","of","bags","made","for","collecting","dust","in","a","vacuum","cleaner","."),1105848).
assertion_content_comment('tObjectValentinesCard',s("The","collection","of","#$","GreetingCards","that","are","sold","for/","and","or","sent","on/before","#$","ValentinesDay","each","year",".","Such","cards","are","often","send","anonymously",",","to","express","love/affection/lust","for","another","person",".","People","in","relationships","are","often","expected","to","send","cards","to","their","partners",".","The","cards","celebrate","#$","ValentinesDay",",","a","religious","holiday","that","commemorates","(","#$","SaintFn","#$","Valentine-TheMartyr",")",",","though","the","life","(","and","martyrdom",")","of","this","#$","Saint","have","little","to","do","with","the","idea","of","#$","ValentinesCard","It","is","probable","that","the","secular","holiday","arose","because","the","feast","day","of","(","#$","SaintFn","#$","Valentine-TheMartyr",")","occurs","close","to","a","pagan","#$","Love","festival","."),1082557).
assertion_content_comment('tObjectValveMechanical',s("The","collection","of","all","manufactured","#$","Valves",".","Each","instance","of","this","collection","consists","of","a","section","of","#$","FluidConduit","with","at","least","one","moving","part","which","can","limit","the","volume","or","direction","of","flow","within","a","system",".","Every","#$","Valve-Mechanical","is","a","#$","FlowControlDevice",".","A","#$","PhysicalDevice","which","inserts","and","removes","a","#$","Stopper","would","be","a","#$","FlowControlDevice","and",",","also",",","a","#$","Valve","if","the","surrounding","#$","FluidConduit","was","included","."),1103358).
assertion_content_comment('tObjectValvePositionGaugeLongString',s("The","collection","of","all","devices","made","to","measure","valve","position","for","a","flow","control","valve","in","the","long","string","of","a","well",".","A","type","of","#$","ValvePositionGauge","."),4545668).
assertion_content_comment('tObjectValvePositionGaugeShortString',s("The","collection","of","all","devices","made","to","measure","valve","position","for","a","flow","control","valve","in","the","short","string","of","a","well",".","A","type","of","#$","ValvePositionGauge","."),4545664).
assertion_content_comment('tObjectValvePositionGauge',s("The","collection","of","all","devices","made","to","measure","valve","position",".","A","type","of","#$","Gauge","."),4545648).
assertion_content_comment('tObjectVane',s("The","flat",",","blade-like","components","of","a","windmill","that","catch","the","wind","and","turn","the","turbine"),1110226).
assertion_content_comment('tObjectVanillaExtract',s("A","alcolhol","extract","of","vanillin",",","derived","from","vanilla","beans",",","which","is","used","as","a","flavoring","agent","."),1104664).
assertion_content_comment('tObjectVanityMirror',s("The","collection","of","#$","VanityMirrors",".","A","#$","VanityMirror","has","two","#$","Mirrors",",","one","of","which","has","a","higher","magnification","than","the","other",".","Usually","the","#$","Mirrors","are","circular","and","are","mounted","to","something","thin",",","back","to","back",".","The","mirrors","revolve","in","such","a","manner","that","you","can","have","either","mirror","facing","forward",".","#$","VanityMirrors","don","'","t","require","the","use","of","a","hand","or","a","wall","mounting",".","They","are","mounted","in","a","stand","which","has","the","axle","that","the","#$","Mirrors","turn","on",".","If","one","were","to","use","a","#$","VanityMirror",",","it","usually","sits","on","a","table","or","counter","in","the","#$","BedRoom","or","in","the","#$","Bathroom-Home","where","one","'","s","#$","Makeup","is","applied","."),1087993).
assertion_content_comment('tObjectVan',s("Vans","are","vehicles","that","can","hold","lotsa","people","or","things","(","like","drum","sets",")","Can","be","adapted","for","mobility","impaired","people","."),1070155).
assertion_content_comment('tObjectVarnish',s("Transparent","liquid","applied","to","wood","and","other","materials","in","order","to","seal","and","protect","it",".","After","application",",","#$","Varnish","will","dry","and","harden",".","Many","types","of","varnish","exist",",","including","those","made","with","polyurethane",",","epoxies",",","lacquer",",","acrylic","polymers","and","more","."),4752253).
assertion_content_comment('tObjectVascoIdiazabalCheese',s("This","the","collection","of","all","instances","of","Vasco","Idiazabal",",","a","Basque","|","|","sheep","'","s","milk","cheese","."),1104752).
assertion_content_comment('tObjectVascularStent',s("A","specialization","of","#$","PhysicalDevice",".","Each","instance","of","#$","VascularStent","is","a","wire","mesh","tube","used","to","repair","damaged","arteries","."),2831249).
assertion_content_comment('tObjectVase',s("A","container","or","vessel","capable","of","holding","water",",","in","which","flowers","are","displayed","or","arranged","."),1096463).
assertion_content_comment('tObjectVasotec',s("A","medicine","marketed","by","Merck","&","Co",",","used","to","treat","hypertension",".","It","'","s","active","ingredient","is","the","ACE","inhibitor","#$","Enalapril","."),3117850).
assertion_content_comment('tObjectVAX',s("The","set","of","DEC","VAX","machines","."),1071414).
assertion_content_comment('tObjectVeganCuisine',s("A","type","of","cuisine","that","excludes","all","meat","(","including","fish",",","poultry",",","and","seafood",")","and","all","animal","products","(","such","as","eggs",",","honey",",","and","milk","products",")"),1094530).
assertion_content_comment('tObjectVegetarianCuisine',s("a","type","of","cuisine","which","includes","plant","products",",","and","usually","dairy","products","and","eggs",",","but","no","animal","flesh","."),1101232).
assertion_content_comment('tObjectVegetarianSausage',s("A","specialization","of","#$","Sausage",".","Each","instance","of","#$","VegetarianSausage","is","a","sausage","which","contains","no","meat","or","meat","by-products","."),2997078).
assertion_content_comment('tObjectVehicleDoorKey',s("A","type","of","#$","VehicleKey",".","#$","VehicleDoorKey","is","a","#$","SpatiallyDisjointObjectType","."),3015204).
assertion_content_comment('tObjectVehicleIgnitionKey',s("A","type","of","#$","VehicleKey",".","#$","VehicleIgnitionKey","is","a","#$","SpatiallyDisjointObjectType","."),3015205).
assertion_content_comment('tObjectVehicleKey',s("The","collection","of","all","keys","to","vehicles","A","type","of","#$","KeyOfLock",".","#$","VehicleKey","is","a","#$","SpatiallyDisjointObjectType","."),3010346).
assertion_content_comment('tObjectVehicleTrackDevice',s("The","collection","of","all","instances","of","|","|","#$","Belt-Mechanical","that","are","the","defining","|","|","feature","of","#$","TrackedVehicles",".","On","such","|","|","vehicles",",","each","(","there","are","usually","two",")","|","|","#$","VehicleTrack-Device","|","|","is","strapped","around","a","series","of","|","|","#$","LandTransportationWheels",".","The","#$","Wheels","|","|","turn",",","and","the","vehicle","rolls","|","|","along","the","tracks","(","instead","of","#$","Tires",")"),1105941).
assertion_content_comment('tObjectVehicleTrunkKey',s("A","type","of","#$","VehicleKey",".","#$","VehicleTrunkKey","is","a","#$","SpatiallyDisjointObjectType","."),3015206).
assertion_content_comment('tObjectVehicleTypeByIntendedOperatingEnvironmentTypeFn',s("A","#$","CollectionDenotingFunction",".","Where","PLACE-TYPE","is","a","kind","of","#$","Place",",","(","#$","VehicleTypeByIntendedOperatingEnvironmentTypeFn","PLACE-TYPE",")","returns","the","collection","of","all","instances","of","#$","TransportationDevice-Vehicle","that","are","designed","to","serve","as","#$","transporters","in","vehicular","#$","TransportationEvents","that","occur","in","places","of","type","PLACE-TYPE","."),5410866).
assertion_content_comment('tObjectVehicleTypeByIntendedUseTypeFn',s("A","#$","CollectionDenotingFunction",".","Where","EVENT-TYPE","is","a","kind","of","#$","Event",",","(","#$","VehicleTypeByIntendedUseTypeFn","EVENT-TYPE",")","denotes","the","collection","of","all","instances","of","#$","TransportationDevice-Vehicle","designed","to","be","#$","deviceUsed","in","instances","of","EVENT-TYPE","."),5410963).
assertion_content_comment('tObjectVehicleTypeByPathwayFn',s("A","#$","CollectionDenotingFunction",".","Where","PLACE","is","an","instance","of","#$","Place",",","(","#$","VehicleTypeByPathwayFn","PLACE",")","denotes","the","class","of","all","instances","of","#$","TransportationDevice-Vehicle","designed","to","operate","in","PLACE",":","more","specifically",",","every","#$","TransportationDevice-Vehicle","designed","to","operate","as","a","#$","transporter","in","vehicluar","#$","TransportationEvents","that","occur","at","(","#$","eventOccursAt",")","PLACE","."),5410764).
assertion_content_comment('tObjectVehicleUniversalKey',s("A","type","of","#$","VehicleKey",".","#$","VehicleUniversalKey","is","a","#$","SpatiallyDisjointObjectType","."),3015207).
assertion_content_comment('tObjectVehicleValetKey',s("A","type","of","#$","VehicleKey",".","#$","VehicleValetKey","is","a","#$","SpatiallyDisjointObjectType","."),3015208).
assertion_content_comment('tObjectVeil',s("The","collection","of","all","veils",".","A","type","of","#$","ClothingAccessory",",","#$","SurfaceRegion-Finite",",","#$","SurfaceRegion-Tangible",",","#$","SurfaceRegion-Bounded",",","#$","FreeSheet",",","and","#$","WomensClothing",".","The","concept","#$","Veil","is","a","#$","SomethingToWearTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3032544).
assertion_content_comment('tObjectVelcroTheFastener',s("Pair","of","hook-and-loop","cloth","fasteners","."),1098257).
assertion_content_comment('tObjectVelvetCloth',s("The","collection","of","all","velvet","cloth",".","Velvet","was","traditionally","made","of","silk",",","but","is","now","made","of","synthetic","fiber","or","of","cotton","."),1073416).
assertion_content_comment('tObjectVendingMachine',s("Any","machine","into","which","you","can","put","coins","or","bills",",","and","out","comes","food","!","soda","!","pamphlets","!","and","perhaps","some","change",".","This","does","not","include","ATM","machines","or","change-making","machines",";","they","will","have","a","common","genls","with","#$","VendingMachine","."),1102903).
assertion_content_comment('tObjectVentilationDevice',s("The","collection","of","all","ventilation","devices",".","A","type","of","#$","PhysicalDevice",".","The","concept","#$","VentilationDevice","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3010129).
assertion_content_comment('tObjectVentilator',s("The","collection","of","all","ventilators",".","A","type","of","#$","MedicalDevice","and","#$","Artifact-HumanCreated","."),3032841).
assertion_content_comment('tObjectVentricularAssistDevice',s("A","specialization","of","#$","CardiacAssistDevice",".","Each","instance","of","#$","VentricularAssistDevice","is","a","mechanical","device","designed","to","support","a","failing","heart","by","assisting","the","ventricles","."),2874387).
assertion_content_comment('tObjectVermicelliNoodle',s("A","long","round","really","skinny","noodle","."),1099360).
assertion_content_comment('tObjectVermouth',s("The","collection","of","all","vermouth",",","which","is","a","fortified","wine","flavored","with","herbs","and","spices",".","A","type","of","#$","FortifiedWine",".","The","collection","#$","Vermouth","is","a","#$","DefaultDisjointEdibleStuffType","and","a","#$","TangibleStuffCompositionType","."),3006768).
assertion_content_comment('tObjectVerticalFileCabinetPieceOfFurniture',s("A","type","of","furniture/office","storage","device","used","for","storing","paper","files",".","A","vertical","file","cabinet","is","the","most","common","kind",",","with","a","short","x-axis","and","a","longer","y-axis",".","When","you","open","the","drawers",",","you","are","looking","at","the","flat","sides","of","the","files",",","not","at","their","edges","(","as","you","would","be","with","a","lateral","file","cabinet",")"),1103055).
assertion_content_comment('tObjectVerticalStabilizer',s("The","collection","of","aircraft","vertical","stabilizers",".","Typically",",","an","aircraft","vertical","stabilizer","is","part","of","the","aircraft","'","s","tail","assembly","."),1096953).
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assertion_content_comment('tObjectVertRamp',s("The","collection","of","instances","of","#$","HalfPipe","that","are","sufficiently","large","that","the","rider","is","able","to","propell","him","or","herself","vertically","into","the","air",",","and","thus","land","on","the","ramp",",","rather","than","being","propelled","out","of","the","ramp",",","as","is","typically","the","case","with","a","#$","MiniRamp","."),4741733).
assertion_content_comment('tObjectVeryFormalClothing',s("The","collection","of","clothing","traditionally","worn","on","formal","occasions",".","This","collection","|","includes","such","things","as","tuxedos",",","bridal","gowns",",","patent","leather","pumps",",","etc.","."),1355171).
assertion_content_comment('tObjectVeryHeavyDutyPathArtifact',s("A","specialization","of","#$","PathArtifact",".","Instances","of","this","|","collection","are","those","that","may","accomodate","very","heavy","loads","."),1454978).
assertion_content_comment('tObjectVestBulletproof',s("The","collection","of","#$","Vests","that","are","reinforced","so","as","to","afford","protection","for","the","wearer","against","being","shot","by","a","gun","."),1106555).
assertion_content_comment('tObjectVest',s("The","set","of","all","vests","."),1055806).
assertion_content_comment('tObjectVHSCamcorder',s("Camcorders","which","record","directly","to","#$","VHSCassettes","."),1101015).
assertion_content_comment('tObjectVHSCassette',s("VHS","video","cassettes",".","The","standard","around","the","year","|","|","2000","for","#$","VideoTapePlaying","."),1101478).
assertion_content_comment('tObjectVHSVideoTape',s("Magnetic","tape","suitable","for","video","recording","or","having","been","recorded","with","video","information",".","Each","#$","VHSCassette","has","some","length","of","such","tape","as","a","physical","part","."),3211979).
assertion_content_comment('tObjectViagra',s("The","collection","of","all","Viagra",".","A","type","of","#$","PrescriptionDrug",".","#$","Viagra","is","a","#$","BrandNamePharmacyProductType","and","a","#$","SpatiallyDisjointObjectType","."),3006575).
assertion_content_comment('tObjectVial',s("A","vial","is","a","small","bottle","used","to","contain","liquids",".","It","has","a","cap","on","it","which","may","have","an","opening","where","a","syringe","could","be","inserted","to","extract","the","liquid","inside","."),1097595).
assertion_content_comment('tObjectVictorianClothingStyle',s("The","collection","of","instances","of","#$","SomethingToWear","that","present","a","Victorian","image","."),1188947).
assertion_content_comment('tObjectVictorian',s("The","collection","of","instances","of","#$","ConstructionArtifact","that","are","in","the","|","victorian","style","."),1188894).
assertion_content_comment('tObjectVideoCamera',s("An","instance","of","#$","ArtifactTypeByFunction",".","Each","instance","of","this","collection","is","a","#$","Camera","designed","to","record","moving","images","onto","a","storage","medium","for","later","viewing","."),1146558).
assertion_content_comment('tObjectVideoCassetteBlank',s("This","is","the","collection","of","video","cassettes","|","|","that","have","not","yet","been","recorded","on","."),1095446).
assertion_content_comment('tObjectVideoCassettePreRecorded',s("This","is","the","collection","of","video","cassettes","|","|","that","have","had","something","professionally","recorded","on","them","."),1095676).
assertion_content_comment('tObjectVideoCassetteRecorder',s("The","device","used","to","record","television","programs","or","play","programs","stored","on","a","video","cassette",".","Usually","called","a","VCR"),1101109).
assertion_content_comment('tObjectVideoCassette',s("Video","cassette","tapes",",","blank","or","not","."),1100183).
assertion_content_comment('tObjectVideoClipOfSubjectFn',s("(","#$","VideoClipOfSubjectFn","SUBJECT",")","denotes","the","collection","of","all","#$","VideoClips","in","which","images","of","the","#$","SpatialThing-Localized",",","SUBJECT",",","appear",".","For","example",",","(","#$","VideoClipOfSubjectFn","#$","BillClinton",")","denotes","a","collection","including","all","#$","VideoClips","in","which","images","of","Bill","Clinton","appear",".","Likewise","(","#$","VideoClipOfSubjectFn","#$","FirstLunarLanding",")","denotes","the","collection","of","all","#$","VideoClips","in","which","images","of","the","first","lunar","landing","appear",".","To","denote","the","collection","of","all","#$","VideoClips","in","which","part","of","a","#$","VideoConceptualWork","(","such","as","a","#$","MusicVideo",")","is","recorded",",","use","#$","VideoClipOfWorkFn","."),1104260).
assertion_content_comment('tObjectVideoClipOfWorkFn',s("(","#$","VideoClipOfWorkFn","VIDEOWORK",")","denotes","the","collection","of","all","#$","VideoClips","in","which","a","segment","of","the","#$","VideoConceptualWork","VIDEOWORK","has","been","recorded",".","For","example",",","(","#$","VideoClipOfWorkFn","#$","ApocalypseNow-TheMovie",")","denotes","the","collection","of","all","#$","VideoClips","in","which","a","segment","of","Apocalypse","Now","has","been","recorded","."),1096273).
assertion_content_comment('tObjectVideoClip',s("In","the","#$","BaseKB","we","leave","the","matter","of","what","counts","as","a","short","segment","largely","undecided",".","In","some","contexts","we","may","wish","to","say","that","all","complete","recordings","of","a","#$","MusicVideo","are","#$","VideoClips",".","In","others","we","may","wish","to","say","that","only","segments","of","such","works","(","despite","the","works","'","being","relatively","short",")","are","instances","of","#$","VideoClip",".","Also",",","depending","on","the","meaning","of","#$","VideoRecordedObject",",","in","a","given","a","context",",","it","may","be","the","case","that","no","(","or","all",")","parts","of","a","#$","VideoRecordedObjects","in","which","a","short","segment","of","#$","MovingImages","are","recorded",",","are","#$","VideoClips",".","Accordingly",",","each","10","inch","length","of","VideoTape","of","a","complete","recording","of","#$","Jaws-TheMovie","would","(","or","would","not","be",")","an","instance","of","#$","VideoClip","."),309195).
assertion_content_comment('tObjectVideoClip',s("It","might","be","useful","to","create","related","concepts","such","as","A",".","a","portion","of","a","physical","object","instantiating","a","#$","VideoClip",",","or","B",".","the","vibrations","generated","by","some","#$","PhysicalDevice","given","as","input","a","physical","object","of","type","A","."),309196).
assertion_content_comment('tObjectVideoClip',s("The","collection","of","all","#$","VideoRecordedObjects","the","playings","of","which","have","a","short","duration",",","and","which","are","typically","recordings","(","or","encodings",")","of","portions","of","a","longer","sequence","of","moving","images","that","are","recorded","or","encoded","in","some","other","#$","VideoRecordedObject",".","Examples","include","a","#$","VideoTape","on","which","a","short","segment","of","#$","Jaws-TheMovie","is","recorded",",","a","#$","VideoTape","on","which","a","robbery","is","recorded",",","and","#$","MPEGFile","on","which","a","portion","of","#$","MusicVideo","has","been","encoded",".","#$","VideoClips","which","have","acompanying","audio","portions","are","also","#$","AudioRecordedObjects","(","but","not","#$","AudioClips",")","In","some","microtheories","we","may","wish","to","make","#$","VideoClip","a","spec","of","#$","AudioRecordedObject","."),1096978).
assertion_content_comment('tObjectVideoClipTypeOfSubjectTypeFn',s("","(","#$","VideoClipTypeOfSubjectTypeFn","SUBJECT-TYPE",")","","denotes","the","collection","of","instances","of","#$","VideoRecordedObject","that","depict","instance","(","s",")","of","","SUBJECT-TYPE","",",","a","type","of","#$","SpatialThing-Localized","."),4863604).
assertion_content_comment('tObjectVideoFileCopy',s("A","specialization","of","#$","ComputerFileCopy","whose","instances","encode","video","data","."),5105411).
assertion_content_comment('tObjectVideoFrame',s("The","collection","of","full-screen",",","discrete","units","of","a","#$","VideoClip","."),5026364).
assertion_content_comment('tObjectVideoGameCartridge',s("A","video","game","cartridge","used","in","a","home","video","game","unit","like","Nintendo"),1103204).
assertion_content_comment('tObjectVideoGameSystem',s("The","collection","of","#$","Computers","which","are","specifically","designed","for","playing","games",".","This","collection","inlcudes","handheld","portables",",","consumer","systems","like","Xbox","and","Playstation","as","well","as","stand-alone","arcade","machines",".","For","the","collection","of","such","systems","designed","for","end","user","purchase","see","#$","HomeVideoGameMachine","."),2995912).
assertion_content_comment('tObjectVideoRecordedObject',s("A","collection","of","information","bearing","objects","(","IBOs",")","Each","element","of","#$","VideoRecordedObject","is","a","tangible","object","(","such","as","a","videotape",")","that","contains","visual","information",".","For","mass-produced","videos",",","see","#$","RecordedVideoProduct","."),1104926).
assertion_content_comment('tObjectVideoSurveillanceSystem',s("The","collection","of","all","video","surveillance","systems",".","A","type","of","#$","SecurityDevice",".","The","concept","#$","VideoSurveillanceSystem","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3009878).
assertion_content_comment('tObjectVideoTape',s("Magnetic","tape","suitable","for","video","recording","or","having","been","recorded","with","video","information",".","Each","video","cassette","has","some","length","of","such","tape","as","a","physical","part","."),1102814).
assertion_content_comment('tObjectVidex',s("The","collection","of","all","Videx",".","A","type","of","#$","DrugProduct",".","#$","Videx","is","a","#$","NucleosideReverseTrancriptaseInhibitorDrugClass","and","a","#$","BrandNamePharmacyProductType","."),3010132).
assertion_content_comment('tObjectViennesePotatoSalad',s("The","collection","of","all","Viennese","Potato","salads",".","A","type","of","#$","SideDish","and","#$","Salad",".","#$","ViennesePotatoSalad","is","an","#$","ExistingStuffType","."),3007647).
assertion_content_comment('tObjectVietnamMemorial',s("The","collection","of","all","monuments","which","commemorate","the","#$","Vietnam","War",".","The","most","famous","such","marker","is","a","dramatic","black","slab","in","Washington","DC"),1084845).
assertion_content_comment('tObjectVikingHat',s("The","collection","of","stereotypical","Viking","helms","with","two","horns","stiking","out","of","it",".","Invented","in","the","19th","century","for","use","as","an","operatic","costume","."),1107998).
assertion_content_comment('tObjectVintageArtifact',s("The","collection","of","vintage","artifacts",",","instances","of","#$","DurableGood","that","were","manufactured","during","some","time","period","earlier","than","that","of","the","given","context",",","and","are","characteristic","of","the","best","of","that","time","period",".","For","example",",","vintage","clothing","is","clothing","from","a","particular","time","period",",","say","the","1920","'","s"),4747495).
assertion_content_comment('tObjectVintageFn',s("#$","VintageFn","is","a","variable-arity","subcollection-denoting","function","that","takes","a","type","of","#$","DurableGood","and","returns","a","subcollection","of","that","good","whose","instances","are","all","characteristic","of","the","best","of","that","type","of","good","from","some","historical","period","during","which","those","instances","were","produced",".","The","addition","of","a","second","#$","TimeInterval","argument",",","say","the","1920","'","s",",","will","further","refine","the","specialization","of","that","type","of","good",",","by","indicating","an","aforementioned","historical","period",".","For","example",",","","(","#$","VintageFn","#$","CoffeeTable-PieceOfFurniture",")","","denotes","the","collection","of","vintage","coffee","tables",",","and","","(","#$","VintageFn","#$","CoffeeTable-PieceOfFurniture","(","#$","TimeIntervalInclusiveFn","(","#$","YearFn","1920",")","(","#$","YearFn","1929",")",")",")","","denotes","the","collection","of","vintage","1920-1929","coffee","tables",".","The","latter","collection","is","a","specialization","of","the","former","."),4747473).
assertion_content_comment('tObjectVinyl',s("The","collection","of","all","vinyl",".","A","type","of","#$","Solid-StateOfMatter","and","#$","ArtificialMaterial",".","The","concept","#$","Vinyl","is","a","#$","TangibleStuffCompositionType","and","an","#$","ArtifactTypeByGenericCategory","."),3032920).
assertion_content_comment('tObjectViola',s("stringed","instrument","slightly","larger","than","a","violin"),1100101).
assertion_content_comment('tObjectViolin',s("The","collection","of","all","violins",".","A","type","of","#$","StringInstrument","and","#$","MusicalInstrument-Acoustic",".","The","collection","#$","Violin","is","an","#$","OrchestralStringInstrumentType",",","a","#$","SpatiallyDisjointObjectType",",","and","an","#$","ArtifactTypeByGenericCategory","."),3006968).
assertion_content_comment('tObjectViracept',s("The","collection","of","all","Viracept",".","A","type","of","#$","DrugProduct",".","#$","Viracept","is","a","#$","ProteaseInhibitorDrugClass","and","a","#$","BrandNamePharmacyProductType","."),3008300).
assertion_content_comment('tObjectViramune',s("The","collection","of","all","Viramune",".","A","type","of","#$","DrugProduct",".","#$","Viramune","is","a","#$","NucleosideReverseTrancriptaseInhibitorDrugClass","and","a","#$","BrandNamePharmacyProductType","."),3010134).
assertion_content_comment('tObjectViread',s("The","collection","of","all","Viread",".","A","type","of","#$","DrugProduct",".","#$","Viread","is","a","#$","NucleosideReverseTrancriptaseInhibitorDrugClass","and","a","#$","BrandNamePharmacyProductType","."),3009617).
assertion_content_comment('tObjectVirginiaClassSubmarine',s("A","specialization","of","#$","AttackSubmarine",".","Each","instance","of","#$","VirginiaClassSubmarine","is","an","attack","submarine","built","for","the","U.S",".","Navy","."),2549491).
assertion_content_comment('tObjectVirtualHost',s("A","computer","system","that","is","accessed","by","a","user","working","at","a","remote","location",".","The","specific","machine","pointed","to","by","the","unique","host","IP","address","may","change",",","but","the","expectation","is","that","this","will","not","alter","the","files","and","services","that","the","host","makes","available","."),1420072).
assertion_content_comment('tObjectVirtualPet',s("Instances","are","electronic","toys","which","simulate","a","real","creature",".","Some","are","small",",","with","a","little","LCD","display","and","a","few","buttons","for","input",".","These","devices","are","programmed","to","display","a","representation","of","a","creature","that","is","born/hatches",",","grows",",","and","matures",".","Other","types","of","#$","VirtualPet",",","such","as","the","#$","Furby-TheToy",",","are","doll-like",",","having","the","shape","and","some","of","the","behaviors","of","a","mammal","."),1096549).
assertion_content_comment('tObjectVISACard',s("The","collection","of","all","VISA","cards",".","A","type","of","#$","MajorCreditCard","and","#$","CreditCard-RevolvingAccount",".","#$","VISACard","is","a","#$","CreditCardTypeByBrand","."),3007273).
assertion_content_comment('tObjectVisaDocument',s("A","specialization","of","#$","LegalDocument",".","Each","instance","of","#$","Visa-Document","is","a","document","issued","by","the","government","of","some","country","to","one","(","or","more",")","person","(","s",")",",","authorizing","that","person","(","or","those","persons",")","to","enter","that","country","and","remain","for","a","certain","period","of","time","while","engaging","in","certain","specified","activities","(","e.g.",",","study",",","travel",",","work",")"),1107487).
assertion_content_comment('tObjectViscometer',s("A","device","used","for","measuring","the","viscosity","of","a","fluid","."),4441754).
assertion_content_comment('tObjectVise',s("A","device","used","to","hold","an","object","in","a","certain","position","such","that","it","doesn","'","t","move","while","it","is","acted","on","."),1097195).
assertion_content_comment('tObjectVisorAccessory',s("The","collection","of","all","visor","accessories",".","A","type","of","#$","PhysicalDevice",".","The","concept","#$","VisorAccessory","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3009390).
assertion_content_comment('tObjectVisorCap',s("The","collection","of","all","visors",".","A","type","of","#$","Cap",".","The","collection","#$","Visor-Cap","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3006916).
assertion_content_comment('tObjectVisorCap',s("This","term","designates","headgear","that","consists","of","a","headband","attached","to","an","eyeshade",".","For","the","eyeshade","part","alone",",","see","the","term","#$","HatBill","."),812178).
assertion_content_comment('tObjectVisualDisplayScreen',s("The","collection","of","visual","display","screens","--","relatively","flat","surfaces","(","though","some","projection","screens","are","rolled","up","when","not","in","use",")","designed","to","be","the","area","where","images","appear","during","the","projection","or","generation","of","an","image",".","Instances","include","movie","screens","and","the","slightly","curved","panes","of","glass","at","the","end","of","a","cathode","ray","tube",".","Though","a","sufficiently","flat","and","uniformly","colored","wall","can","be","used","as","a","screen",",","this","collection","only","includes","devices","for","which","this","is","their","primary","function",".","So","though","it","is","possible","for","a","wall","to","belong","to","this","collection",",","such","instances","are","atypical","."),2066778).
assertion_content_comment('tObjectVisualInformationRecordingDevice',s("A","specialization","of","#$","PhysicalDevice",".","Each","instance","of","#$","VisualInformationRecordingDevice","is","a","device","used","for","the","recording","of","visual","information",".","So","an","instance","would","be","your","cam-corder","(","a","#$","VideoCamera",")","or","your","VCR","(","#$","VideoCassetteRecorder",")"),3135244).
assertion_content_comment('tObjectVisualLabel',s("The","collection","of","all","labels","that","present","their","information","content","visually",".","Thus","a","label","with","a","barcode","is","an","instance","of","#$","VisualLabel",",","as","are","more","common","labels",".","Neither","radio","isotope","labelling","nor","magnetic","labels","are","instances","of","#$","VisualLabel"),1080992).
assertion_content_comment('tObjectVitaminForChildren',s("The","collection","of","all","children","'","s","vitamins",".","A","type","of","#$","MultiVitamin",".","#$","Vitamin-ForChildren","is","a","#$","PharmacyProductType-Level0","."),3008219).
assertion_content_comment('tObjectVitaminForMen',s("The","collection","of","all","men","'","s","vitamins",".","A","type","of","#$","MultiVitamin",".","#$","Vitamin-ForMen","is","a","#$","PharmacyProductType-Level0","."),3010135).
assertion_content_comment('tObjectVitaminForWomen',s("The","collection","of","all","women","'","s","vitamins",".","A","type","of","#$","MultiVitamin",".","#$","Vitamin-ForWomen","is","a","#$","PharmacyProductType-Level0","."),3010136).
assertion_content_comment('tObjectVitaminPill',s("The","collection","of","all","vitamin","pills",".","A","type","of","#$","DietarySupplement",",","#$","ManufacturedGoods",",","and","#$","Pill",".","The","collection","#$","VitaminPill","is","a","#$","PharmacyProductType","."),3006236).
assertion_content_comment('tObjectVitrine',s("The","collection","of","all","vitrines",".","A","type","of","#$","AccentFurniture",".","#$","Vitrine","is","a","#$","SpatiallyDisjointObjectType","."),3010507).
assertion_content_comment('tObjectVodka',s("The","collection","of","all","vodka",".","A","type","of","#$","Liquor-Drink","and","#$","ColorlessThing",".","The","collection","#$","Vodka","is","a","#$","DefaultDisjointEdibleStuffType","and","a","#$","TangibleStuffCompositionType",".","Each","instance","of","#$","Vodka","is","a","clear","liquid","made","from","distilled","potatoes","(","or",",","less","frequently",",","grain","or","sugar","beets",")"),3006303).
assertion_content_comment('tObjectVoiceDataDeviceNetwork',s("A","kind","of","#$","ComputerHardwareItem",".","Instances","are","devices","that","process","audio","data","for","transmission/distribution","over","a","network","."),5022825).
assertion_content_comment('tObjectVoiceLoggingDevice',s("The","collection","of","all","information","recording","devices","used","to","log","audio/voice","communication","."),4574916).
assertion_content_comment('tObjectVoiceMailDevice',s("The","collection","of","all","voice","mail","devices",".","They","are","normally","(","2001",")","part","of","a","telephone","system","and","handle","multiple","telephone","lines","for","telephones","in","different","locations",".","They","are","distinct","from","telephone","#$","AnsweringMachines","which","are","associated","with","a","single","telephone","line","."),1213536).
assertion_content_comment('tObjectVoicemailIndicatorLight',s("The","collection","of","all","lights","on","electronic","devices","that","indicate","a","new","voicemail","."),3759720).
assertion_content_comment('tObjectVoicemail',s("The","collection","of","all","#$","AudioRecordedObjects","that","are","recordings","of","vocal","messages","recorded","(","typically",")","onto","a","telephone","answering","system",".","The","audio","of","each","recorded","message","will","be","associated","with","a","particular","textual","information","structure","(","#$","PropositionalCWText",")","that","is","itself","associated","with","a","#$","PropositionalConceptualWork","--","i.e",".","the","abstract","propositional","content","of","the","message","."),3751895).
assertion_content_comment('tObjectVoiceRecognitionDevice',s("#$","VoiceRecognitionDevice","is","a","subset","of","#$","BiometricAuthenticationDevice",".","Individuals","in","the","collection","#$","VoiceRecognitionDevice","measure","the","sound","spectrograph","pattern","of","a","person","'","s","utterance","of","a","pass","phrase",",","and","attempt","to","match","the","pattern","with","a","stored","representation","of","it","."),1080907).
assertion_content_comment('tObjectVOIPPhonePointToPointCapable',s("The","collection","of","all","PBX","devices","that","have","the","capability","to","do","always","on","point-to-point","VOIP","(","Hoot","&","Holler",")"),5023059).
assertion_content_comment('tObjectVolkswagenCar',s("The","collection","of","all","VW","cars",".","A","type","of","#$","GermanCar",".","The","collection","#$","VolkswagenCar","is","an","#$","AutomobileTypeByBrand",",","a","#$","SpatiallyDisjointObjectType",",","and","a","#$","ManufacturedGoodsType","."),3006384).
assertion_content_comment('tObjectVolkwagenBeetleCar',s("The","collection","of","all","Volkwagen","Bug",".","A","type","of","#$","VolkswagenCar",".","#$","VolkwagenBeetleCar","is","an","#$","AutomobileTypeByModel","and","a","#$","SpatiallyDisjointObjectType","."),3008496).
assertion_content_comment('tObjectVolleyballBall',s("The","ball","manipulated","in","a","volley-ball","game","."),1071014).
assertion_content_comment('tObjectVolleyballCourt',s("A","court","where","volleyball","is","played","."),1065832).
assertion_content_comment('tObjectVolleyballSet',s("The","collection","of","all","volleyball","sets",".","A","type","of","#$","SportsEquipment",".","The","collection","#$","VolleyballSet","is","an","(","#$","EquipmentTypeForStructuredActivityFn","#$","Volleyball",")","and","an","#$","ArtifactTypeByGenericCategory","."),3007262).
assertion_content_comment('tObjectVoltageConverter',s("The","collection","of","all","voltage","converters",".","A","type","of","#$","TravelAccessory",",","#$","ElectricalDevice",",","and","travel","accessory",".","#$","VoltageConverter","is","a","#$","SpatiallyDisjointObjectType","."),3008382).
assertion_content_comment('tObjectVoltageSource',s("A","source","of","electrical","voltage"),1071202).
assertion_content_comment('tObjectVoltmeter',s("Device","for","measuring","electrical","voltage","which","is","commonly","used","in","repairing","electrical","devices"),1100060).
assertion_content_comment('tObjectVolumeMeasuringDevice',s("Devices","used","to","measure","volume",",","such","as","cup","measure",",","graduated","cylinders",",","and","cooking","teaspoons","."),1110271).
assertion_content_comment('tObjectVolvoCar',s("The","collection","of","all","Volvo","cars",".","A","type","of","#$","SwedishCar",".","The","collection","#$","VolvoCar","is","an","#$","AutomobileTypeByBrand","and","a","#$","SpatiallyDisjointObjectType","."),3006733).
assertion_content_comment('tObjectVoterRegistrationCard',s("An","instance","of","#$","OfficialDocumentType",",","and","a","specialization","of","#$","IDDocument",".","Each","instance","of","#$","VoterRegistrationCard","is","a","document","certifying","that","its","holder","can","vote","in","certain","elections",".","Instances","of","#$","VoterRegistrationCard","will","typically","include","the","following","information",":","the","name","of","the","voter",",","his","or","her","address",",","his","or","her","party","affiliation",",","and","the","polling","place","for","his","or","her","voting","precinct",".","In","some","jurisdictions",",","a","voter","may","be","required","to","display","an","appropriate","instance","of","#$","VoterRegistrationCard","in","order","to","vote","in","certain","elections","."),1109093).
assertion_content_comment('tObjectVPNNetworkAccessDevice',s("The","collection","of","remote","access","devices","designed","to","provide","access/authentication/etc",".","to","VPN","networks","."),4574919).
assertion_content_comment('tObjectVulnerableBecauseAdministratorCalledAdministrator',s("A","specialization","of","#$","VulnerableBecauseOfInsecureUsernames",".","A","computer","has","this","vulnerability","if","its","#$","AdministratorAccount","is","named","'","Administrator","'",",","which","is","well-known","to","be","the","default","username","for","this","(","privileged",")","account",",","and","can","easily","be","changed","."),1216169).
assertion_content_comment('tObjectVulnerableBecauseAllowsAnonymousFTP',s("A","computer","has","this","vulnerability","if","it","allows","remote","users","|","of","an","instance","of","#$","FTPServerProgram","to","log","in","to","the","service","without","authentication.","|","In","most","cases",",","the","user","simply","types","in","\"","anonymous","\"","for","the","username","|","and","a","(","real","or","fictional",")","email","address","for","the","password","."),1111713).
assertion_content_comment('tObjectVulnerableBecauseAllowsUnlimitedLoginAttempts',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","UnlimitedLoginAttemptFault","on","it","."),1108746).
assertion_content_comment('tObjectVulnerableBecauseCanUseAlerterService',s("I","'","m","not","sure","what","having","this","service","enabled","allows","attackers","to","be","able","to","do...The","CIS","'","Gold","Standard","'","is","clear","about","removing","it","though","."),1216305).
assertion_content_comment('tObjectVulnerableBecauseCanUseMessengerService',s("I","'","m","not","sure","what","having","this","service","enabled","allows","attackers","to","be","able","to","do...The","CIS","'","Gold","Standard","'","is","clear","about","removing","it","though","."),1216334).
assertion_content_comment('tObjectVulnerableBecauseHasDictionaryPassword',s("An","attribute","applying","to","instances","of","#$","Computer",".","A","computer","system","is","#$","VulnerableBecauseHasDictionaryPassword","if","an","account","accessible","from","it","has","a","#$","Password-Computer","that","is","a","word","found","in","a","standard","dictionary.","|","|","This","is","a","vulnerability","because","several","computer","hacking","programs","work","|","|","by","trying","to","login","in","using","dictionary","terms","."),1078017).
assertion_content_comment('tObjectVulnerableBecauseHasPredictableTCPSequenceNumbers',s("An","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","its","operating","system","orders","its","TCP","sequence","numbers","in","a","manner","that","allows","prediction","."),1085021).
assertion_content_comment('tObjectVulnerableBecauseHasSameUsernameAndPassword',s("#$","VulnerableBecauseHasSameUsernameAndPassword","is","an","attribute","that","applies","to","some","instances","of","#$","Computer","as","well","as","accounts","on","such","systems",".","An","|","account","accessible","from","a","computer","is","#$","VulnerableBecauseHasSameUsernameAndPassword","if","the","#$","Password-Computer","for","that","account","is","the","same","as","the","#$","Username","for","that","account","."),1078721).
assertion_content_comment('tObjectVulnerableBecauseHasWeakPassword',s("An","attribute","of","some","instances","of","#$","ComputationalSystem",".","A","computational","system","is","#$","VulnerableBecauseHasWeakPassword","if","the","#$","Password-Computer","for","an","account","on","it","is","a","#$","Password-Weak","."),1077659).
assertion_content_comment('tObjectVulnerableBecauseNoActivityLoggingNTScheduling',s("A","specialization","of","#$","VulnerableBecauseNoActivityLogging",".","A","computer","has","this","vulnerability","if","its","#$","ComputerAuditLogFile","does","not","record","uses","of","the","Scheduling","command","."),1214900).
assertion_content_comment('tObjectVulnerableBecauseNoActivityLogging',s("A","computer","has","this","vulnerability","if","it","has","a","#$","ComputerAuditLogFile","which",",","for","some","reason",",","is","not","being","used","(","to","log","at","least","some","of","the","events","it","should","log",")","Thus","no","records",",","or","faulty","records",",","are","kept","of","activities","performed","on","that","computer",",","including","those","performed","by","attackers",".","Where","this","occurs","because","the","computer","is","running","software","with","an","#$","ActivityLogBypassFault",",","see","the","more","specialized","#$","VulnerableToActivityLogBypass","."),1214222).
assertion_content_comment('tObjectVulnerableBecauseNoActivityLogging',s("The","rule","below","is","a","relatively","crude","one","which","just","fires","if","no","logging","is","going","on","at","all",",","but","the","values","which","the","registry","key","concerned","takes","(","i.e",".","the","sources","which","are","being","logged",",","e.g",".","'","Spooler","'",",","'","Security","Account","Manager","'",")","allows","for","some","much","more","sophisticated","reasoning..","."),1214217).
assertion_content_comment('tObjectVulnerableBecauseNoLegalNotice',s("Legal","precedents","exist","where","intruders","have","escaped","conviction","by","protesting","that","they","were","never","'","warned","'","that","the","system","was","private","property","etc....","."),881014).
assertion_content_comment('tObjectVulnerableBecauseOfBrowserConfiguration',s("#$","VulnerableBecauseOfBrowserConfiguration","is","a","specialization","of","|","#$","ProgramConfigurationVulnerability",".","It","is","a","vulnerability","of","a","computer","|","that","arises","as","a","consequence","of","the","configuration","of","a","browser","|","installed","on","the","computer","."),1096692).
assertion_content_comment('tObjectVulnerableBecauseOfGlobalRootPrivileges',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","|","#$","GlobalRootPrivilegesFault","on","it","."),1107562).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureCreditCardAccountInformation',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","|","#$","InsecureCreditCardAccountInformationFault","on","it","."),1110558).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureDataStorage',s("A","computer","has","this","vulnerability","if","it","has","a","program","on","it","with","a","#$","InsecureDataStorageFault","."),1106206).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureDataStorage',s("If","the","data","is","in","file","form",",","then","use","the","spec",".","#$","VulnerableBecauseOfInsecureFiles","."),780142).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureDTMLFiles',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","InsecureDTMLFilesFault","on","it","."),1110015).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureEncryptionKey',s("A","computer","has","this","vulnerability","if","is","running","a","server","|","program","with","a","#$","InsecureEncryptionKeyFault","."),1109851).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureFiles',s("A","computer","has","this","vulnerability","if","it","has","a","program","on","it","with","a","#$","InsecureFilesFault","."),1111849).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureJavaCode',s("A","computer","has","this","vulnerability","if","it","has","a","program","on","it","|","with","a","#$","InsecureJavaCodeFault","."),1260701).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureLogin',s("(","note","to","self",")","keep","an","eye","out","for","ways","to","make","the","3","rules","asserted","on","this","vulnerability","apply","to","something","more","specific","."),882652).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureMailListAdministrationPages',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","InsecureMailListAdministrationPagesFault","on","it","."),1109184).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureMailStorage',s("A","computer","has","this","vulnerability","if","it","has","a","program","on","it","|","with","a","#$","InsecureMailStorageFault-System","."),3096408).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureMailSystemConfigurationData',s("A","computer","has","this","vulnerability","if","it","has","a","program","on","it","with","a","#$","InsecureMailSystemConfigurationDataFault","."),1113725).
assertion_content_comment('tObjectVulnerableBecauseOfInsecurePasswordFile',s("A","computer","has","this","vulnerability","if","it","has","a","program","on","it","with","a","#$","InsecurePasswordFileFault","."),1111614).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureScriptSourceCode',s("A","computer","has","this","vulnerability","if","it","has","a","program","on","it","with","a","#$","InsecureScriptSourceCodeFault","."),1111267).
assertion_content_comment('tObjectVulnerableBecauseOfInsecureUsernames',s("A","computer","has","this","vulnerability","if","it","can","be","used","to","discern","usernames","for","the","network","of","which","it","is","a","part","in","an","unauthorized","fashion",".","This","might","be","because","it","has","a","program","with","an","#$","InsecureUsernameFault","on","it",",","or","for","other","reasons","."),1108485).
assertion_content_comment('tObjectVulnerableBecauseOfJavaEnabledBrowser',s("#$","VulnerableBecauseOfJavaEnabledBrowser","is","a","specialization","of","|","|","#$","VulnerableBecauseOfListeningBrowserInterpreter",".","It","is","a","vulnerability","of","a","|","|","computer","that","arises","as","a","consequence","of","configuring","a","browser","on","a","|","|","computer","to","enable","Java","programs","to","run","."),1104841).
assertion_content_comment('tObjectVulnerableBecauseOfJavaScriptEnabledBrowser',s("#$","VulnerableBecauseOfJavaScriptEnabledBrowser","is","a","specialization","of","|","#$","VulnerableBecauseOfBrowserConfiguration",".","It","is","a","vulnerability","of","a","|","computer","that","arises","as","a","consequence","of","configuring","a","browser","on","a","|","computer","to","enable","JavaScript","."),1104604).
assertion_content_comment('tObjectVulnerableBecauseOfListeningBrowserInterpreter',s("#$","VulnerableBecauseOfListeningBrowserInterpreter","is","a","specialization","of","|","|","#$","VulnerableBecauseOfBrowserConfiguration",".","It","is","a","vulnerability","of","a","computer","|","|","that","arises","as","a","consequence","of","permitting","a","web","browser","on","the","|","|","computer","to","use","an","instance","of","#$","Interpreter-Computers","as","a","helper","|","|","application","."),1097646).
assertion_content_comment('tObjectVulnerableBecauseOfListeningInterpreter',s("#$","VulnerableBecauseOfListeningInterpreter","is","a","specialization","of","|","#$","ProgramConfigurationVulnerability",".","It","is","a","vulnerability","of","a","computer","|","that","arises","as","a","consequence","of","permitting","an","instance","of","#$","Interpreter-Computers","installed","on","a","computer","to","be","listening","on","an","instance","of","#$","NetworkPortNumber","."),1097407).
assertion_content_comment('tObjectVulnerableBecauseOfMacroCapableBrowserHelper',s("#$","VulnerableBecauseOfMacroCapableBrowserHelper","is","a","specialization","of","|","|","#$","VulnerableBecauseOfBrowserConfiguration","and","#$","VulnerableBecauseOfMacroCapableProgram",".","It","is","a","vulnerability","of","a","computer","that","arises","as","a","consequence","of","allowing","a","macro-capable","program",",","such","as","#$","MSWord","or","#$","MSExcel",",","to","be","a","browser","helper",".","See","#$","MacroVirus","and","#$","macroCapable","."),1096934).
assertion_content_comment('tObjectVulnerableBecauseOfMacroCapableProgram',s("#$","VulnerableBecauseOfMacroCapableProgram","is","a","specialization","of","|","#$","ProgramConfigurationVulnerability",".","It","is","a","vulnerability","of","a","computer","|","that","arises","as","a","consequence","of","installing","macro-capable","programs",",","|","such","as","#$","MSWord","or","#$","MSExcel",".","See","#$","MacroVirus","and","#$","macroCapable","."),1096461).
assertion_content_comment('tObjectVulnerableBecauseOfPlaintextApplicationPasswordFile',s("A","computer","has","this","vulnerability","if","it","has","a","program","installed","on","it","that","stores","the","passwords","for","accessing","that","program","in","a","plaintext","file",".","This","would","allow","a","local","user","who","does","not","have","authorized","access","to","that","program","to","hijack","a","legitimate","user","'","s","account","."),1109187).
assertion_content_comment('tObjectVulnerableBecauseOfPlaintextPasswordFile',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","PlaintextPasswordFileFault","on","it","."),1107406).
assertion_content_comment('tObjectVulnerableBecauseOfPlaintextSystemPasswordFile',s("A","computer","has","this","vulnerability","if","it","has","an","operating","system","with","a","#$","PlaintextSystemPasswordFileFault","on","it","."),1108531).
assertion_content_comment('tObjectVulnerableBecauseOfPredictableEncryptionKey',s("A","computer","his","this","vulnerability","if","it","has","a","program","with","a","#$","PredictableEncryptionKeyFault","on","it","."),1107110).
assertion_content_comment('tObjectVulnerableBecauseOfPredictableSessionID',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","PredictableSessionIDFault","on","it","."),1109033).
assertion_content_comment('tObjectVulnerableBecauseOfReadableKernelMemory',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","|","#$","ReadableKernelMemoryFault","on","it","."),1106476).
assertion_content_comment('tObjectVulnerableBecauseOfReadableMail',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","ReadableMailFault","on","it","."),1111538).
assertion_content_comment('tObjectVulnerableBecauseOfShellPathUnderspecification',s("A","computer","has","this","vulnerability","if","it","runs","an","#$","OperatingSystem","with","an","#$","NTShellPathUnderspecificationFault","."),1107550).
assertion_content_comment('tObjectVulnerableBecauseOfUnderspecifiedPath',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","UnderspecifiedPathFault","on","it",".","Note","that","this","vulnerability","is","exclusively","a","#$","LocalComputerVulnerabilityAttribute","."),1110600).
assertion_content_comment('tObjectVulnerableBecauseOfUnneededSoftware',s("I","originally","created","this","constant","when","treating","the","fact","that","OS/2","and","POSIX","are","enabled","on","instances","of","#$","NTMachine","as","a","security","risk",".","This","has","turned","out","not","to","be","necessary",",","but","I","thought","the","constant","might","as","well","stay","."),881242).
assertion_content_comment('tObjectVulnerableBecauseOfWeakAdministratorPasswordReset',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","WeakPasswordResetFault-Administrator","on","it","."),1107730).
assertion_content_comment('tObjectVulnerableBecauseOfWeaklyEncryptedApplicationPasswordFile',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","WeaklyEncryptedApplicationPasswordFileFault","on","it","."),1110484).
assertion_content_comment('tObjectVulnerableBecauseOfWeaklyEncryptedPasswordFile',s("A","vulnerability","attribute","of","some","computers",".","A","computer","is","|","|","#$","VulnerableBecauseOfWeaklyEncryptedPasswordFile","if","it","is","|","|","running","a","program","that","uses","a","weak","encryption","algorithm","to","store","passwords","in","a","|","|","file","on","the","computer",".","This","means","that","someone","who","acquires","the","|","|","encrypted","passwords","can","decode","them","without","knowing","the","encryption","|","|","algorithm","or","the","encryption","key","."),1077905).
assertion_content_comment('tObjectVulnerableBecauseOfWeaklyEncryptedSystemPasswordFile',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","WeaklyEncryptedSystemPasswordFileFault","on","it","."),1108923).
assertion_content_comment('tObjectVulnerableBecauseOfWeakPasswordReset',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","|","#$","WeakPasswordResetFault","on","it","."),1110169).
assertion_content_comment('tObjectVulnerableBecauseOfWeakPasswordTransmissionEncryption',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","WeakPasswordTransmissionEncryptionFault","on","it","."),1106252).
assertion_content_comment('tObjectVulnerableBecauseProxyDisabled',s("A","computer","has","this","vulnerability","if","it","is","meant","to","use","a","proxy","server","in","at","least","some","contexts","and","this","functionality","has","been","disabled","(","for","instance","through","the","registry",",","if","it","is","a","Windows","machine",")"),1215788).
assertion_content_comment('tObjectVulnerableBecauseProxyDisabled',s("The","potential","for","more","sophisticated","reasoning","exists","re",".","Windows","registry","keys","than","the","rule","below",".","(","e.g",".","checking","which","pathnames","exist","in","the","'","ProxyOverride","'","key",")","However",",","this","would","seem","to","require","representing","the","proxy","server","(","s",")","for","a","given","network","etc.",",","which","we","don","'","t","currently","do","."),1215784).
assertion_content_comment('tObjectVulnerableBecauseTransmitsInPlaintext',s("A","vulnerability","attribute","of","some","instances","of","#$","ComputationalSystem",".","(","#$","hasVulnerability","COMP","#$","VulnerableBecauseTransmitsInPlaintext",")","means","that","there","is","some","#$","NetworkingProgram","on","COMP","which","does","not","encrypt","data","before","sending","it","over","a","network","."),1078049).
assertion_content_comment('tObjectVulnerableToActivityLogBypass',s("#$","VulnerableToActivityLogBypass","is","a","specialization","of","#$","VulnerableToSecuritySoftwareBypass",".","A","computer","has","this","vulnerability","if","a","program","running","on","the","computer","should","log","a","certain","type","of","activity","and","yet","a","user","can","exploit","some","feature","of","the","program","to","ensure","that","such","activity","is","not","logged",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","software","with","an","#$","ActivityLogBypassFault","."),1109816).
assertion_content_comment('tObjectVulnerableToActivityMonitoring',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","ActivityMonitoringFault","on","it","."),1107865).
assertion_content_comment('tObjectVulnerableToArbitraryContentArbitraryFileOverwrite',s("#$","VulnerableToArbitraryContentArbitraryFileOverwrite","is","a","specialization","of","#$","VulnerableToArbitraryFileOverwrite",".","A","computer","has","this","vulnerability","if","it","allows","unauthorized","users","to","overwrite","any","file","with","any","content","."),1106516).
assertion_content_comment('tObjectVulnerableToArbitraryFileDeletion',s("This","vulnerability","is","a","specialization","of","#$","VulnerableToFileDeletion",".","A","computer","has","this","vulnerability","if","it","is","possible","for","an","unauthorized","person","to","delete","arbitrary","files","from","the","computer","."),1107416).
assertion_content_comment('tObjectVulnerableToArbitraryFileOverwrite',s("#$","VulnerableToArbitraryFileOverwrite","is","a","specialization","of","|","#$","VulnerableToFileOverwrite",".","A","computer","has","this","vulnerability","if","|","it","allows","unauthorized","users","to","overwrite","any","file","."),1106414).
assertion_content_comment('tObjectVulnerableToAttachmentFilteringBypass',s("#$","VulnerableToAttachmentFilteringBypass","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","possible","to","bypass","an","attachment","filtering","procedure","that","software","running","on","the","computer","is","supposed","to","implement",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","software","with","an","#$","AttachmentFilteringBypassFault","."),1110259).
assertion_content_comment('tObjectVulnerableToAuthenticationSoftwareBypass',s("#$","VulnerableToAuthenticationSoftwareBypass","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","possible","to","bypass","an","authentication","procedure","that","software","running","on","the","computer","is","supposed","to","implement","."),1108022).
assertion_content_comment('tObjectVulnerableToAutomaticHTMLAttachmentDownload',s("#$","VulnerableToAutomaticHTMLAttachmentDownload","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","running","software","with","an","#$","AutomaticHTMLAttachmentDownloadFault","."),1111240).
assertion_content_comment('tObjectVulnerableToBinGroupSymlinkAttack',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","SymlinkFault-BinGroupOnly","on","it","."),1109400).
assertion_content_comment('tObjectVulnerableToBounceAttack',s("A","vulnerability","had","by","instances","of","|","#$","Computer",".","A","computer","is","#$","VulnerableToBounceAttack","if","an","attacker","can","|","establish","a","connection","between","it","and","an","arbitrary","port","on","another","|","system",".","This","connection","may","be","used","to","bypass","access","controls","that","|","would","otherwise","apply",".","This","vulnerability","typically","arises","as","a","|","consequence","of","running","a","server","program","with","an","|","#$","ArbitraryDestinationPortFault","."),1099315).
assertion_content_comment('tObjectVulnerableToBufferOverflow',s("#$","VulnerableToBufferOverflow","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","the","vulnerability","#$","VulnerableToBufferOverflow","if","it","uses","a","buffer","with","a","configuration","that","can","be","exploited","in","an","#$","AttackByComputerOperation-BufferOverflow","."),1076576).
assertion_content_comment('tObjectVulnerableToBulletinBoardPostOverwrite',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","BulletinBoardPostOverwriteFault","on","it","."),1110385).
assertion_content_comment('tObjectVulnerableToCABFileExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","CABFileExecutionFault","on","it","."),1107186).
assertion_content_comment('tObjectVulnerableToCacheBypass',s("A","computer","has","this","vulnerability","if","it","is","running","a","program","with","a","#$","CacheBypassFault","."),1110810).
assertion_content_comment('tObjectVulnerableToCachePoisoning',s("A","computer","has","this","vulnerability","if","it","running","a","server","program","that","has","a","#$","CachePoisoningFault","."),1109513).
assertion_content_comment('tObjectVulnerableToCertificateSpoofing',s("A","computer","has","this","vulnerability","if","it","has","a","program","|","that","has","a","#$","CertificateSourceValidationFault","."),1111379).
assertion_content_comment('tObjectVulnerableToCGICommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","web","server","program","with","a","#$","CGICommandExecutionFault","or","a","#$","WebServerCGICommandExecutionFault","on","it","."),1108858).
assertion_content_comment('tObjectVulnerableToCommandFilteringBypass',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","CommandFilteringBypassFault","on","it","."),1109464).
assertion_content_comment('tObjectVulnerableToComputerVirusInfiltration',s("An","attribute","applying","to","instances","of","#$","ComputationalSystem",".","A","computational","system","has","the","attribute","#$","VulnerableToComputerVirusInfiltration","if","it","is","configured","in","such","a","way","as","to","allow","a","known","instance","of","#$","ComputerVirus","to","infiltrate","the","system","."),1076937).
assertion_content_comment('tObjectVulnerableToComputerWormInfiltration',s("An","attribute","of","some","instances","of","#$","ComputationalSystem",".","A","computational","system","has","the","attribute","#$","VulnerableToComputerWormInfiltration","if","it","is","configured","in","such","a","way","as","to","allow","an","instance","of","#$","ComputerWorm","to","infiltrate","the","system","."),1109541).
assertion_content_comment('tObjectVulnerableToContentFilteringBypass',s("#$","VulnerableToContentFilteringBypass","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","possible","to","bypass","a","content","filtering","procedure","that","software","running","on","the","computer","is","supposed","to","implement",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","software","with","a","#$","ContentFilteringBypassFault","."),1110361).
assertion_content_comment('tObjectVulnerableToCoreDump',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","CoreDumpFault","on","it","."),1107667).
assertion_content_comment('tObjectVulnerableToCrossSiteScriptingAttack',s("A","computer","is","#$","VulnerableToCrossSiteScriptingAttack","if","it","|","is","running","a","program","that","has","a","#$","CrossSiteScriptingFault",".","Users","of","|","this","computer","may","unintentionally","execute","scripts","written","by","an","|","attacker","when","they","follow","hyperlinks","in","web","pages",",","mail","messages",",","|","or","newsgroup","postings","."),1106990).
assertion_content_comment('tObjectVulnerableToDataCorruption',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","DataCorruptionFault","on","it","."),1107983).
assertion_content_comment('tObjectVulnerableToDenialOfService',s("#$","VulnerableToDenialOfService","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","the","attribute","#$","VulnerableToDenialOfService","if","it","is","configured","to","receive","data","in","a","way","that","enables","an","#$","AttackByComputerOperation-DenialOfService","to","be","performed","on","it",".","One","common","way","for","a","computer","to","be","configured","in","this","way","would","be","for","it","to","be","running","a","program","that","has","a","#$","DenialOfServiceFault","."),1077312).
assertion_content_comment('tObjectVulnerableToDesktopSecuritySoftwareBypass',s("#$","VulnerableToDesktopSecuritySoftwareBypass","is","a","specialization","of","#$","VulnerableToUserRestrictionBypass",".","A","computer","has","this","fault","if","it","is","running","a","#$","DesktopSecurityProgram","with","a","#$","DesktopSecuritySoftwareBypassFault",".","It","is","a","#$","LocalComputerVulnerabilityAttribute","because","it","only","applies","when","a","machine","runs","software","that","restricts","local","users","."),1110673).
assertion_content_comment('tObjectVulnerableToDeviceDriverCrashing',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","DeviceDriverCrashingFault","on","it","."),1108046).
assertion_content_comment('tObjectVulnerableToDigitalSignatureBypass',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","DigitalSignatureBypassFault","on","it","."),1111416).
assertion_content_comment('tObjectVulnerableToDirectoryAccess',s("A","computer","has","this","vulnerability","if","it","is","running","a","server","program","with","a","#$","DirectoryAccessFault","."),1109596).
assertion_content_comment('tObjectVulnerableToDirectoryProbing',s("A","computer","has","this","vulnerability","if","it","is","running","a","server","program","with","a","#$","DirectoryProbingFault","."),1108123).
assertion_content_comment('tObjectVulnerableToDirectoryTraversal',s("A","computer","has","this","vulnerability","if","it","is","running","a","server","program","with","a","#$","DirectoryTraversalFault","."),1111029).
assertion_content_comment('tObjectVulnerableToDiskUsageManagementSoftwareBypass',s("#$","VulnerableToDiskUsageManagementSoftwareBypass","is","a","specialization","of","#$","VulnerableToUserRestrictionBypass",".","A","computer","has","this","fault","if","it","is","running","a","program","with","a","#$","DiskUsageManagementSoftwareBypassFault",".","It","is","a","#$","LocalComputerVulnerabilityAttribute","because","it","only","applies","when","a","machine","runs","software","that","restricts","local","users","."),1110782).
assertion_content_comment('tObjectVulnerableToDisplayLockBypass',s("#$","VulnerableToDisplayLockBypass","is","a","specialization","of","#$","VulnerableToUserRestrictionBypass",".","A","computer","has","this","vulnerabilty","if","it","is","possible","for","an","attacker","to","unlock","it","without","supplying","the","proper","password",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","a","program","with","a","#$","DisplayLockBypassFault","."),1110901).
assertion_content_comment('tObjectVulnerableToDNSCachePoisoning',s("A","computer","has","this","vulnerability","if","it","running","a","server","|","program","that","has","a","#$","DNSCachePoisoningFault","."),1106710).
assertion_content_comment('tObjectVulnerableToDomainSocketDenialOfService',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","|","#$","DomainSocketDenialOfServiceFault","on","it","."),1109075).
assertion_content_comment('tObjectVulnerableToEavesdropping',s("An","attribute","applying","to","instances","of","#$","Computer",".","A","computer","system","is","#$","VulnerableToEavesdropping","if","it","can","be","used","by","anyone","logged","in","to","it","to","listen","to","audible","events","in","its","vicinity","."),1111895).
assertion_content_comment('tObjectVulnerableToElevatedPrivilegePrinting',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","PrintingElevatedPrivilegeFault","on","it",".","See","also","#$","VulnerableToUnauthorizedPrinterAccountAccess","."),1106685).
assertion_content_comment('tObjectVulnerableToEmailReplyCommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","EMailReplyCommandExecutionFault","on","it","."),1109731).
assertion_content_comment('tObjectVulnerableToEncryptionKeyRecovery',s("A","computer","his","this","vulnerability","if","it","has","a","program","with","a","#$","RecoverableEncryptionKeyFault","on","it","."),1107218).
assertion_content_comment('tObjectVulnerableToEscapeFromRestrictedShell',s("A","program","may","restrict","users","from","having","full","access","to","a","shell",",","which","effectively","limits","the","ability","to","perform","a","range","of","commands",".","If","an","unauthorized","user","is","able","to","escape","from","a","restricted","shell",",","his","privileges","are","elevated",".","For","example",",","the","user","may","traverse","the","directory","or","execute","commands","on","the","system","at","will",".","See","also","#$","VulnerableToUnauthorizedRootAccess","."),1177779).
assertion_content_comment('tObjectVulnerableToExecutionOfDLL',s("A","computer","has","this","vulnerability","if","it","has","a","program","on","it","that","has","a","#$","CommandExecutionOfDLLFault","."),1110174).
assertion_content_comment('tObjectVulnerableToFileCommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","FileCommandExecutionFault","on","it","."),1109253).
assertion_content_comment('tObjectVulnerableToFileCreationRootOwnership',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","FileCreationFault-RootOwnership","on","it","."),1111780).
assertion_content_comment('tObjectVulnerableToFileCreation',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","FileCreationFault","on","it","."),1111656).
assertion_content_comment('tObjectVulnerableToFileDeletion',s("#$","VulnerableToFileDeletion","is","a","specialization","of","|","#$","VulnerableToFileOverwrite",".","A","computer","has","this","vulnerability","if","|","it","allows","unauthorized","users","to","delete","certain","files","."),1100407).
assertion_content_comment('tObjectVulnerableToFileDeletionSymlinkAttack',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","SymlinkFault-Deletion","on","it","."),1109800).
assertion_content_comment('tObjectVulnerableToFileModification',s("#$","VulnerableToFileModification","is","a","specialization","of","#$","ComputerVulnerability",".","A","computer","has","this","vulnerability","if","it","is","it","allows","an","unauthorized","user","either","to","overwrite",",","delete",",","or","recover","|","files","."),1111703).
assertion_content_comment('tObjectVulnerableToFileOverwrite',s("#$","VulnerableToFileOverwrite","is","a","specialization","of","#$","VulnerableToFileModification",".","A","computer","has","this","vulnerability","if","it","allows","unauthorized","users","to","overwrite","certain","files","."),1111937).
assertion_content_comment('tObjectVulnerableToFileOverwriteSymlinkAttack',s("A","vulnerability","of","some","instances","of","#$","Computer",".","A","computer","|","is","#$","VulnerableToFileOverwriteSymlinkAttack","if","it","is","running","a","program","that","allows","|","a","user","to","create","symlinks","to","and","then","overwrite","arbitrary","files","on","the","computer",",","including","|","files","for","which","the","user","does","not","have","authorized","access","."),1078603).
assertion_content_comment('tObjectVulnerableToFileRecovery',s("#$","VulnerableToFileRecovery","is","a","specialization","of","|","#$","VulnerableBecauseOfInsecureDataStorage",".","A","computer","has","this","vulnerability","if","|","it","allows","unauthorized","users","to","recover","files","from","it","."),1106297).
assertion_content_comment('tObjectVulnerableToFileUpload',s("A","computer","has","this","vulnerability","if","is","running","a","server","program","with","a","#$","UnauthorizedFileUploadFault","."),1111148).
assertion_content_comment('tObjectVulnerableToFilteringSoftwareBypass',s("#$","VulnerableToFilteringSoftwareBypass","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","possible","to","bypass","a","filtering","procedure","that","software","running","on","the","computer","is","supposed","to","implement","."),1110142).
assertion_content_comment('tObjectVulnerableToFirewallBypass',s("A","spec-attribute","of","#$","ComputerVulnerability",".","If","a","computer","is","#$","VulnerableToFirewallBypass",",","it","is","possible","to","send","data","to","some","machine","on","the","network","over","some","port","which","is","supposedly","blocked","by","the","network","'","s","firewall","."),1101799).
assertion_content_comment('tObjectVulnerableToFTPCommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","FTPCommandExecutionFault","on","it","."),1110243).
assertion_content_comment('tObjectVulnerableToHyperlinkCommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","HyperlinkCommandExecutionFault","on","it","."),1108699).
assertion_content_comment('tObjectVulnerableToInterfaceStatisticsReset',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","InterfaceStatisticsResetFault","on","it","."),1110282).
assertion_content_comment('tObjectVulnerableToIPDisclosure',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","IPDisclosureFault","on","it","."),1107233).
assertion_content_comment('tObjectVulnerableToIPPacketForwarding',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","IPPacketForwardingFault","on","it","."),1110346).
assertion_content_comment('tObjectVulnerableToJavaAccessingUnauthorizedFiles',s("A","computer","has","this","vulnerability","if","is","has","a","program","|","with","a","#$","JavaFileAccessFault","."),1109300).
assertion_content_comment('tObjectVulnerableToJavaCommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","JavaCommandExecutionFault","on","it","."),1109950).
assertion_content_comment('tObjectVulnerableToJavascriptCommandExecution',s("A","computer","has","this","vulnerability","if","is","has","a","program","on","it","that","has","a","#$","JavascriptCommandExecutionFault","."),1110603).
assertion_content_comment('tObjectVulnerableToJavascriptFileCommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","JavascriptFileExecutionFault","on","it","."),1260970).
assertion_content_comment('tObjectVulnerableToJavascriptSurveillance',s("A","computer","has","this","vulnerability","if","it","has","a","program","that","has","a","#$","JavascriptSurveillanceFault","."),1110929).
assertion_content_comment('tObjectVulnerableToKerberosIDSpoofing',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","KerberosIDSpoofingFault","on","it","."),1106912).
assertion_content_comment('tObjectVulnerableToKerberosIDSpoofing',s("It","would","probably","be","better","if","this","vuln","could","be","defined","as","the","computer","being","on","a","*","network","*","where","a","|","#$","KerberosIDSpoofingFault","lurks","somewhere....","."),796118).
assertion_content_comment('tObjectVulnerableToKerberosKDCSpoofing',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","KerberosKDCSpoofingFault","on","it","."),1108597).
assertion_content_comment('tObjectVulnerableToKernelMemoryCorruption',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","CorruptibleKernelMemoryFault","on","it","."),1109910).
assertion_content_comment('tObjectVulnerableToLogFileOverwrite',s("A","specialization","of","#$","VulnerableToFileOverwrite",".","A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","LogFileOverwriteFault","on","it",",","or","if","for","some","other","reason","it","allows","people","to","overwrite","log","files","on","it",".","See","also","#$","VulnerableToUnauthorizedSystemLogAccess",",","#$","VulnerableBecauseNoActivityLogging","."),1113531).
assertion_content_comment('tObjectVulnerableToLoginDenial',s("A","computer","has","this","vulnerability","if","it","is","running","a","login","program","that","can","be","corrupted","by","an","unauthorized","user",",","making","it","|","impossible","for","legitimate","users","to","log","in",".","This","vulnerability","is","locally","exploitable","when","it","is","a","vulnerability","that","is","the","consequence","of","running","a","faulty","local","application",".","This","vulnerability","is","remotely","exploitable","when","it","is","the","consequence","of","running","a","faulty","operating","system","or","server","program","."),1109077).
assertion_content_comment('tObjectVulnerableToMailAccessSymlinkAttack',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","SymlinkFault-MailSpool","on","it","."),1109689).
assertion_content_comment('tObjectVulnerableToMailCommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","|","#$","EMailCommandExecutionFault","on","it","."),1110055).
assertion_content_comment('tObjectVulnerableToMailServerSpoofing',s("It","would","probably","be","better","if","this","vuln","could","be","defined","as","the","computer","being","on","a","*","network","*","where","a","|","#$","SpoofableMailServerFault","lurks","somewhere....","."),1262831).
assertion_content_comment('tObjectVulnerableToMaliciousCodeInstallationFn',s("(","#$","hasVulnerability","COMP","(","#$","VulnerableToMaliciousCodeInstallationFn","MALWARE",")",")","means","that","software","on","COMP","makes","it","possible","for","MALWARE","to","be","installed","on","COMP","."),1111404).
assertion_content_comment('tObjectVulnerableToMaliciousHelpFileCommandExecution',s("A","computer","has","this","vulnerability","if","it","is","running","a","program","with","a","#$","HelpFileCommandExecutionFault","."),1109954).
assertion_content_comment('tObjectVulnerableToMountRequestForwarding',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","MountRequestForwardingFault","on","it","."),1107937).
assertion_content_comment('tObjectVulnerableToNetBIOSCachePoisoning',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","|","#$","NetBIOSCachePoisoningFault","on","it","."),1106371).
assertion_content_comment('tObjectVulnerableToNetworkIntrusionDetectionBypass',s("#$","VulnerableToNetworkIntrusionDetectionBypass","is","a","specialization","of","#$","VulnerableToActivityLogBypass",".","A","computer","has","this","vulnerability","if","an","intrusion","detection","program","running","on","the","computer","allows","remote","attackers","to","attack","the","network","without","detecting","the","attack",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","software","with","a","#$","NetworkIntrusionDetectionBypassFault","."),1109924).
assertion_content_comment('tObjectVulnerableToNISCachePoisoning',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","NISCachePoisoningFault","on","it","."),1109510).
assertion_content_comment('tObjectVulnerableToNISDomainRestrictionBypass',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","NISDomainRestrictionBypassFault","on","it","."),1109140).
assertion_content_comment('tObjectVulnerableToOSCrashing',s("#$","VulnerableToOSCrashing","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","running","a","program","on","a","port",",","and","that","program","crashes","the","entire","|","computer","in","response","to","invalid","input","."),1084666).
assertion_content_comment('tObjectVulnerableToPacketAttackFn',s("(","#$","hasVulnerability","COMP","(","#$","VulnerableToPacketAttackFn","PROTOCOL",")",")","means","that","COMP","can","be","caused","to","crash","by","a","remote","attacker","who","sends","a","#$","Packet-Network","to","COMP","which","nominally","conforms","to","PROTOCOL","but","which","is","malformed","in","some","way","."),1109376).
assertion_content_comment('tObjectVulnerableToPacketFilteringBypass',s("#$","VulnerableToPacketFilteringBypass","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","possible","to","bypass","a","packet","filtering","procedure","that","software","running","on","the","computer","is","supposed","to","implement",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","software","with","a","#$","PacketFilteringBypassFault","."),1110461).
assertion_content_comment('tObjectVulnerableToPerlCommandExecution',s("A","computer","has","this","vulnerability","if","is","has","a","program","that","has","a","#$","PerlCommandExecutionFault","."),1110286).
assertion_content_comment('tObjectVulnerableToPhysicalPathDisclosure',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","PhysicalPathDisclosureFault","on","it","."),1106585).
assertion_content_comment('tObjectVulnerableToPortDenialOfService',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","PortDenialOfServiceFault","on","it","."),1107020).
assertion_content_comment('tObjectVulnerableToPortscanProtectionBypass',s("#$","VulnerableToPortscanProtectionBypass","is","a","specialization","of","#$","VulnerableToActivityLogBypass",".","A","computer","has","this","vulnerability","if","a","#$","FirewallProgram","running","on","it","allows","remote","attackers","to","conduct","a","port","scan","on","its","network","without","logging","the","attack",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","a","program","with","a","#$","PortscanProtectionBypassFault","."),1110030).
assertion_content_comment('tObjectVulnerableToPostScriptCommandExecution',s("A","computer","has","this","vulnerability","if","is","has","a","program","on","it","that","has","a","#$","PostScriptCommandExecutionFault","that","can","be","exploited","locally","."),1110059).
assertion_content_comment('tObjectVulnerableToPrivilegeEscalation',s("A","vulnerability","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","running","a","program","that","allows","(","authorized","or","unauthorized",")","users","to","raise","their","privileges","on","the","system","to","a","level","that","they","are","not","authorized","to","have","."),1086487).
assertion_content_comment('tObjectVulnerableToProcessExploitingSymlinkAttack',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","SymlinkFault-ProcessExploiting","on","it","."),1108157).
assertion_content_comment('tObjectVulnerableToProgramCrashing',s("#$","VulnerableToProgramCrashing","is","a","vulnerability","had","by","instances","of","#$","Computer",".","A","computer","has","this","attribute","if","it","is","running","a","program","that","crashes","in","response","to","certain","invalid","input","."),1099583).
assertion_content_comment('tObjectVulnerableToProgramSlowing',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","ProgramSlowingFault","on","it","."),1107830).
assertion_content_comment('tObjectVulnerableToProxySpoofing',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","SpoofableProxyFault","on","it","."),1109357).
assertion_content_comment('tObjectVulnerableToProxySpoofing',s("It","would","probably","be","better","if","this","vuln","could","be","defined","as","the","computer","being","on","a","*","network","*","where","a","|","#$","SpoofableProxyFault","lurks","somewhere....","."),803741).
assertion_content_comment('tObjectVulnerableToRouterBypass',s("A","computer","has","this","vulnerability","if","it","is","running","a","router","program","that","has","a","#$","RouterBypassFault","."),1111492).
assertion_content_comment('tObjectVulnerableToRpcRequestForwarding',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","RpcRequestForwardingFault","on","it","."),1107121).
assertion_content_comment('tObjectVulnerableToSchemeCommandExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","|","#$","SchemeCommandExecutionFault","on","it","."),1107449).
assertion_content_comment('tObjectVulnerableToSecuritySoftwareBypass',s("#$","VulnerableToSecuritySoftwareBypass","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","possible","to","bypass","an","security","procedure","that","software","running","on","the","computer","is","supposed","to","implement",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","software","with","an","#$","SecuritySoftwareBypassFault","."),1109707).
assertion_content_comment('tObjectVulnerableToStackProtectionBypass',s("#$","VulnerableToStackProtectionBypass","is","a","specialization","of","|","#$","VulnerableToSecuritySoftwareBypass",".","A","computer","has","this","vulnerability","if","it","is","running","software","with","a","#$","StackProtectionBypassFault","."),1111119).
assertion_content_comment('tObjectVulnerableToStartupFileOverwrite',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","StartupFileOverwriteFault","on","it","."),1109295).
assertion_content_comment('tObjectVulnerableToSwitchCrashing',s("A","switch","computer","has","this","vulnerability","if","it","has","a","program","|","with","a","#$","SwitchCrashingFault","on","it","."),1111887).
assertion_content_comment('tObjectVulnerableToSymlinkAttack',s("A","vulnerability","of","some","instances","of","#$","Computer",".","A","computer","|","is","#$","VulnerableToFileOverwriteSymlinkAttack","if","it","is","running","a","program","that","allows","|","a","user","to","create","symlinks","to","and","either","execute","commands","or","overwrite","arbitrary","files","on","the","computer",",","including","|","commands","and","files","for","which","the","user","does","not","have","authorized","access","."),1106646).
assertion_content_comment('tObjectVulnerableToSymlinkCommandExecutionAttack',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","SymlinkFault-Execute","on","it","."),1108816).
assertion_content_comment('tObjectVulnerableToSYNFlood',s("#$","VulnerableToSYNFlood","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","running","an","operating","system","that","fails","to","handle","excessive","streams","of","malformed","|","SYN","packets","."),1082906).
assertion_content_comment('tObjectVulnerableToTCPChorusing',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","TCPChorusingFault","on","it","."),1106800).
assertion_content_comment('tObjectVulnerableToTCPIPParameterModification',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","TCP-IPParameterModificationFault","on","it","."),1107521).
assertion_content_comment('tObjectVulnerableToTCPPortDenialOfService',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","|","#$","TCPPortDenialOfServiceFault","on","it","."),1107344).
assertion_content_comment('tObjectVulnerableToTearDropAttack',s("#$","VulnerableToTearDropAttack","is","an","attribute","of","some","instances","of","#$","Computer",".","A","computer","has","this","vulnerability","if","it","is","running","an","operating","system","that","fails","to","handle","a","deliberately","malformed","|","UDP","(","#$","UserDatagramProtocol",")","packet",".","In","a","Teardrop","attack",",","a","remote","attacker","sends","one","or","multiple","fragmented","UDP","packets","to","a","host",",","which","have","the","correct","(","according","to","the","IP","header",")","fragment","sizes","but","false","(","according","to","the","IP","header",")","fragment","offsets",".","The","result","is","that","the","destination","host","'","s","memory","allocation","fails","and","the","OS","crashes","."),1083602).
assertion_content_comment('tObjectVulnerableToUnauthorizedAccess',s("A","computer","has","this","vulnerability","if","it","is","possible","for","unauthorized","users","to","gain","some","kind","of","user","rights","on","it","(","where","this","has","been","deliberately","left","vague","and","includes","such","things","as","reading","files",",","using","devices","connected","to","the","computer",")","Sometimes","this","occurs","because","a","piece","of","software","on","the","machine","has","an","#$","AccessValidationFault",",","sometimes","because","it","is","on","a","network","which","has","been","wrongly","configured","."),1104922).
assertion_content_comment('tObjectVulnerableToUnauthorizedADKInsertion',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","UnauthorizedADKFault","."),1109403).
assertion_content_comment('tObjectVulnerableToUnauthorizedAdministratorAccess',s("A","computer","has","this","vulnerability","if","it","allows","an","unauthorized","user","to","access","an","administrator","account",".","When","remotely","exploitable",",","it","is","a","consequence","of","an","#$","ExternalAccessToAccountsFault-RemoteAdministrator","When","locally","exploitable",",","it","is","typically","a","consequence","of","an","#$","ElevatedPrivilegeFault-Administrator","."),1108049).
assertion_content_comment('tObjectVulnerableToUnauthorizedBinGroupAccess',s("A","computer","has","this","vulnerability","if","it","is","has","a","program","that","has","a","#$","SetGIDFault-bin","."),1109625).
assertion_content_comment('tObjectVulnerableToUnauthorizedCDRomAccess',s("A","specialization","of","#$","AllowsSharedCDRomAccess","and","#$","VulnerableToUnauthorizedAccess",".","A","computer","has","this","vulnerability","if","it","is","possible","for","its","#$","CD-ROMDrive","to","be","accessed","by","someone","other","than","the","currently","logged","on","user","."),1114032).
assertion_content_comment('tObjectVulnerableToUnauthorizedDecryption',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","an","#$","EncryptionFault","on","it","."),1108255).
assertion_content_comment('tObjectVulnerableToUnauthorizedDLLUpload',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","UnauthorizedDLLUploadFault","on","it","."),1107778).
assertion_content_comment('tObjectVulnerableToUnauthorizedDomainAdministratorAccess',s("A","computer","has","this","vulnerability","if","it","allows","an","unauthorized","user","to","access","a","domain","administrator","account",".","When","remotely","exploitable",",","it","is","a","consequence","of","an","#$","ExternalAccessToAccountsFault-RemoteAdministrator","When","locally","exploitable",",","it","is","typically","a","consequence","of","an","#$","ElevatedPrivilegeFault-Administrator","."),1257977).
assertion_content_comment('tObjectVulnerableToUnauthorizedDomainSocketConnection',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","DefaultDomainSocketConnectionFault","on","it","."),1108635).
assertion_content_comment('tObjectVulnerableToUnauthorizedEncryptionKeyAlteration',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","AlterableEncryptionKeyFault","on","it","."),1108366).
assertion_content_comment('tObjectVulnerableToUnauthorizedFilePermissionChange',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","ChangeFilePermissionsFault","on","it","."),1109848).
assertion_content_comment('tObjectVulnerableToUnauthorizedFloppyDriveAccess',s("A","specialization","of","#$","AllowsSharedFloppyAccess","and","#$","VulnerableToUnauthorizedAccess",".","A","computer","has","this","vulnerability","if","it","is","possible","for","its","#$","FloppyDiskDrive","to","be","accessed","by","someone","other","than","the","currently","logged","on","user","."),1113947).
assertion_content_comment('tObjectVulnerableToUnauthorizedGroupAccess',s("A","computer","has","his","vulnerability","if","it","allows","an","|","unauthorized","user","to","access","a","group","account","."),1111824).
assertion_content_comment('tObjectVulnerableToUnauthorizedHTMLSourceEditing',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","HTMLSourceEditingFault","on","it","."),1109621).
assertion_content_comment('tObjectVulnerableToUnauthorizedLocalAdministratorAccess',s("A","computer","has","this","vulnerability","if","it","allows","an","unauthorized","user","to","access","its","local","administrator","account",".","When","remotely","exploitable",",","it","is","a","consequence","of","an","#$","ExternalAccessToAccountsFault-RemoteAdministrator","When","locally","exploitable",",","it","is","typically","a","consequence","of","an","#$","ElevatedPrivilegeFault-LocalAdministrator","."),1258047).
assertion_content_comment('tObjectVulnerableToUnauthorizedMacroExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","UnauthorizedMacroExecutionFault","on","it","."),1109575).
assertion_content_comment('tObjectVulnerableToUnauthorizedPasswordProtectedMacroExecution',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","PasswordProtectedMacroExecutionFault","on","it","."),1110128).
assertion_content_comment('tObjectVulnerableToUnauthorizedPhysicalRootAccess',s("A","computer","has","this","vulnerability","if","its","operating","system","permits","someone","with","physical","access","to","it","to","interfere","with","the","boot","script","and","thereby","gain","access","to","an","account","with","root","privilege",".","See","also","#$","BootFault-RootAccess","."),1109735).
assertion_content_comment('tObjectVulnerableToUnauthorizedPrinterAccountAccess',s("A","computer","has","this","vulnerability","if","it","allows","an","unauthorized","user","to","access","a","printer","account",".","See","also","#$","VulnerableToElevatedPrivilegePrinting",",","#$","VulnerableToUnauthorizedDeviceAttachment","."),1111467).
assertion_content_comment('tObjectVulnerableToUnauthorizedProcessKilling',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","ProcessKillFault","on","it","."),1107301).
assertion_content_comment('tObjectVulnerableToUnauthorizedProgramAdministratorAccess',s("Sometime","in","the","future",",","perhaps","make","#$","ElevatedPrivilegeFault-ProgramAdministrator","a","function","which","takes","the","name","of","the","program","whose","privileges","are","being","stolen","as","an","arg",",","and","pipe","this","into","this","vulnerability","'","s","generation","to","make","it","more","informative","."),1258060).
assertion_content_comment('tObjectVulnerableToUnauthorizedRegistryAccess',s("[","from","Q153183","-","MS","KB","]","\"","Some","services","need","remote","access","to","the","registry","to","function","correctly",".","For","example",",","the","Directory","Replicator","service","and","the","Spooler","service","|","|","when","connecting","to","a","printer","over","the","network","require","access","to","the","remote","registry",".","You","can","either","add","the","account","name","that","the","service","is","running","under","to","the","access","list","of","the","\"","winreg","\"","key",",","or","you","can","configure","Windows","to","bypass","the","access","restriction","to","certain","keys","by","listing","them","in","the","Machine","or","Users","value","under","the","AllowedPaths","key",":","|","|","HKEY_LOCAL_MACHINE","\\","SYSTEM","\\","CurrentControlSet","\\","Control","\\","SecurePipeServers","\\","winreg","\\","AllowedPath.","\""),881355).
assertion_content_comment('tObjectVulnerableToUnauthorizedRootAccess',s("A","computer","has","this","vulnerability","if","it","allows","an","unauthorized","user","to","access","a","root","account",".","When","exploitable","locally",",","it","is","typically","a","consequence","of","an","#$","ElevatedPrivilegeFault-Root",".","When","exploitable","remotely",",","it","is","typically","the","consequence","of","an","#$","ExternalAccessToAccountsFault-Root",".","See","also","#$","VulnerableToEscapeFromRestrictedShell","."),1111706).
assertion_content_comment('tObjectVulnerableToUnauthorizedSystemLogAccess',s("A","specialization","of","#$","VulnerableToUnauthorizedAccess",".","A","computer","has","this","vulnerability","if","it","is","possible","for","users","to","gain","access","to","files","which","audit/log","the","use","of","the","system","the","computer","is","a","part","of","(","cf",".","#$","ComputerAuditLogFile",")",",","when","not","authorised","to","do","so",".","This","could","be","because","the","computer","has","a","program","with","a","#$","SystemLogAccessFault","on","it",",","or","due","to","a","faulty","configuration",".","This","vulnerability","is","to","be","distinguished","from","#$","VulnerableToActivityLogBypass","--","the","ability","to","bring","it","about","that","activities","are","not","logged","when","they","should","be",".","See","also","#$","VulnerableToLogFileOverwrite","."),1107622).
assertion_content_comment('tObjectVulnerableToUnauthorizedUserAccess',s("A","computer","has","his","vulnerability","if","it","allows","an","unauthorized","user","to","access","a","user","account",".","When","it","is","locally","exploitable",",","it","is","typically","the","consequence","of","an","#$","ElevatedPrivilegeFault-User",".","When","it","is","remotely","exploitable",",","it","is","typically","the","consequence","of","an","#$","ExternalAccessToAccountsFault-User","."),1111941).
assertion_content_comment('tObjectVulnerableToUnauthorizedWebServerAccess',s("A","computer","has","this","vulnerability","if","it","allows","an","unauthorized","user","to","access","an","httpd","account",".","When","remotely","exploitable",",","it","is","typically","a","consequence","of","an","#$","ExternalAccessToAccountsFault-WebServer","."),1111355).
assertion_content_comment('tObjectVulnerableToUserIDSpoofing',s("It","would","probably","be","better","if","this","vuln","could","be","defined","as","the","computer","being","on","a","*","network","*","where","a","|","#$","UserIDSpoofingFault","lurks","somewhere....","."),1263000).
assertion_content_comment('tObjectVulnerableToUserRestrictionBypass',s("#$","VulnerableToUserRestrictionBypass","is","a","specialization","of","#$","VulnerableToSecuritySoftwareBypass",".","A","computer","has","this","fault","if","it","is","possible","to","circumvent","restrictions","that","software","running","on","it","purports","to","make","on","the","range","of","actions","users","are","permitted","to","perform",".","That","is",",","a","computer","has","this","vulnerability","if","it","is","running","software","with","a","#$","UserRestrictionBypassFault",".","It","is","a","#$","LocalComputerVulnerabilityAttribute","because","it","only","applies","when","a","machine","runs","software","that","restricts","local","users","."),1110577).
assertion_content_comment('tObjectVulnerableToVBAScriptCommandExecution',s("A","computer","has","this","vulnerability","if","is","has","a","program","on","it","that","has","a","#$","VBAScriptCommandExecutionFault","."),1110487).
assertion_content_comment('tObjectVulnerableToVBCommandExecution',s("A","computer","has","this","vulnerability","if","is","has","a","program","|","on","it","that","has","a","#$","VBCommandExecutionFault","."),1110389).
assertion_content_comment('tObjectVulnerableToVirusScanBypass',s("#$","VulnerableToVirusScanBypass","is","a","specialization","of","#$","VulnerableToSecuritySoftwareBypass",".","A","computer","has","this","vulnerability","if","it","is","running","a","program","with","a","#$","VirusScanBypassFault","."),1111003).
assertion_content_comment('tObjectVulnerableToWindowManagerAuthorityBypass',s("A","computer","has","this","vulnerability","if","it","has","a","program","with","a","#$","WindowManagerAuthorityBypassFault","on","it","."),1108972).
assertion_content_comment('tObjectVulnerableToWINSFileDeletion',s("A","computer","has","this","vulnerability","if","has","a","program","on","it","|","that","has","a","#$","WINSFileDeletionFault","."),1110702).
assertion_content_comment('tObjectVulnerableToXMLCommandExecution',s("Strictly-speaking",",","XML","is","not","a","programming","language","but","a","\"","metalanguage","\"","which","enables","quick","and","easy","programming","in","other","languages","(","such","as","HTML",")",",","so","I","am","not","sure","how","appropriate","this","fault","and","vulnerability","are",".","However","there","are","definitely","security","risks","associated","with","the","use","of","XML","(","for","instance",",","this","is","why","MS","has","its","\"","block","access","to","data","sources","across","domains","\"","registry","key",".","Can","anyone","clear","this","up","?"),881924).
assertion_content_comment('tObjectWaferDie',s("The","collection","of","all","physical","parts","of","#$","SemiconductorWafer","instances","which","will","eventually","be","laser-sawed","into","separate","#$","IntegratedCircuit","instances","."),4455850).
assertion_content_comment('tObjectWaferDieTypeByResultantICTypeFn',s("A","function","used","in","reifying","sub-classes","of","#$","WaferDie","by","the","type","of","#$","IntegratedCircuit","that","will","eventually","be","produced","from","the","sub-class",".","Where","IC-TYPE","is","a","kind","of","#$","IntegratedCircuit",",","(","#$","WaferDieTypeByResultantICTypeFn","IC-TYPE",")","denotes","the","class","of","all","#$","WaferDie","instances","that","will","eventually","yield","(","be","#$","transformedInto",")","instances","of","IC-TYPE","."),4455892).
assertion_content_comment('tObjectWaferMetrologyElectricalTestCircuit',s("The","collection","of","all","complete","#$","ElectricalCircuits","constructed","solely","to","be","used","in","instances","of","#$","WaferTest-Electrical","."),4504704).
assertion_content_comment('tObjectWaferMetrologyElectricalTestStructure',s("The","collection","of","all","#$","MetrologyTestStructure-Wafer","designed","to","aid","in","electrical","testing","."),4504691).
assertion_content_comment('tObjectWaferMetrologyOpticalTestStructure',s("The","collection","of","all","instances","of","#$","MetrologyTestStructure-Wafer","designed","to","aid","in","measurement","testing","(","#$","WaferTest-Metric",")","involving",",","e.g.",",","overlay","alignment","or","critical","dimension","."),4504685).
assertion_content_comment('tObjectWaffleMaker',s("The","collection","of","all","waffle","irons",".","A","type","of","#$","CookingVessel","and","#$","ManufacturedGoods",".","The","collection","#$","WaffleMaker","is","a","#$","ManufacturedGoodsType",",","a","#$","SpatiallyDisjointObjectType",",","and","an","#$","ArtifactTypeByGenericCategory","."),3008601).
assertion_content_comment('tObjectWagon',s("#$","Wagon","is","a","specialization","of","#$","TransportationContainerProduct",",","#$","WheeledTransportationDevice",",","and","#$","MusclePoweredDevice",".","Each","instance","of","#$","Wagon","is","a","relatively","small","non-motorized","wheeled","device","(","usually","with","two","or","more","wheels",")","used","for","moving","goods",".","Instances","of","#$","Wagon","are","usually","human-powered","or","animal-powered","."),1086979).
assertion_content_comment('tObjectWakazashi',s("The","collection","of","all","wakazashis",".","A","type","of","#$","JapaneseSamuraiSword",".","The","collection","#$","Wakazashi","is","a","#$","WeaponType","and","a","#$","SpatiallyDisjointObjectType","."),3009017).
assertion_content_comment('tObjectWakeboard',s("The","collection","of","waterboards",".","These","are","somewhat","like","waterskis",",","except","|","|","they","are","shorter","and","wider","and","one","uses","only","one",".","They","are","analogous","to","|","|","snowboards","."),1088145).
assertion_content_comment('tObjectWalkerSupportDevice',s("A","device","used","to","help","old","or","disabled","people","to","walk",",","by","giving","them","something","to","lean","on","while","they","step","and/or","rest","between","steps","."),1103862).
assertion_content_comment('tObjectWalkingCane',s("The","collection","of","all","walking","canes",".","A","type","of","#$","RigidPortableObject",",","#$","PhysicalDevice",",","and","#$","Collectible",".","#$","WalkingCane","is","a","#$","SpatiallyDisjointObjectType",".","Each","instance","of","#$","WalkingCane","is","a","medium-length","rigid","stick-shaped","tool","used","by","persons","to","stabilize","themselves","while","walking","."),3006386).
assertion_content_comment('tObjectWalkingShoe',s("The","collection","of","shoes","designed","specifically","|","|","for","walking","."),1094549).
assertion_content_comment('tObjectWalkway',s("The","most","general","collection","of","instances","of","#$","PathArtifact","designed","primarily","for","instances","of","#$","Person","to","walk","along","."),2727302).
assertion_content_comment('tObjectWallClock',s("A","type","of","clock","which","hangs","on","the","wall","."),1105757).
assertion_content_comment('tObjectWallet',s("The","collection","of","all","wallets",",","which","are","small","(","pocket-sized",")","containers","used","to","store","money",",","credit","cards",",","and","personal","identification",".","A","type","of","#$","PersonalDevice","and","#$","TransportationContainerProduct",".","The","collection","#$","Wallet","is","an","#$","ArtifactTypeByFunction","and","a","#$","SpatiallyDisjointObjectType","."),3006695).
assertion_content_comment('tObjectWallHangingArtObject',s("The","collection","of","all","wall","hangings",".","A","type","of","#$","ArtObject",".","#$","WallHanging-ArtObject","is","a","#$","SpatiallyDisjointObjectType","."),3010375).
assertion_content_comment('tObjectWallLight',s("The","collection","of","all","wall","lights",".","A","type","of","#$","ElectricalLightingDevice",".","The","concept","#$","WallLight","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3010138).
assertion_content_comment('tObjectWallMountedDevice',s("The","collection","of","devices","that","are","mounted","on","a","wall","during","normal","usage","--","E.g",".","your","typical","thermostat","."),4740293).
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assertion_content_comment('tObjectWedgeGolfClub',s("a","kind","of","iron","with","an","extreme","slope","primarily","used","to","hit","a","golf","ball","out","of","a","sand","trap","or","short","approach","shots","onto","the","green"),1082447).
assertion_content_comment('tObjectWeightliftingArea',s("The","collection","of","all","weightlifting","areas",".","A","type","of","#$","SportsPlayingArea",".","#$","WeightliftingArea","is","a","#$","SpatiallyDisjointObjectType","."),3010868).
assertion_content_comment('tObjectWeightLiftingBelt',s("The","collection","of","the","(","special",")","belts","worn","by","weight","lifters","while","lifting","weights"),1079584).
assertion_content_comment('tObjectWeightLiftingBench',s("This","is","the","collection","of","weightlifting","|","|","benches",".","These","are","benches",",","sometimes","with","a","part","that","can","be","adjusted","|","|","for","angle",",","which","are","used","to","lie","down","or","sit","when","lifting","weights","."),1104045).
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assertion_content_comment('tObjectWeightLiftingSuit',s("The","very","very","low","cut","leotard-like","body","suit","worn","by","weight-lifters","."),1106595).
assertion_content_comment('tObjectWeightNonPoweredDevice',s("An","instance","of","#$","ArtifactTypeByFunction","and","a","specialization","of","#$","NonPoweredDevice",".","Each","instance","of","#$","Weight-NonPoweredDevice","is","a","rigid","object","having","some","exact","specified","weight","(","for","example",",","10","grams","or","1","kilogram",")",",","and","used","for","weighing","other","objects","(","for","instance",",","on","a","balance","scale",")"),2590258).
assertion_content_comment('tObjectWeldingMask',s("The","masks","worn","by","people","who","are","welding",",","to","protect","their","faces","from","sparks","and","their","eye","from","the","intense","glare","."),1095315).
assertion_content_comment('tObjectWellbore',s("A","specialization","of","#$","PathThroughSolid","and","#$","PathArtifact",".","Wellbores","are","holes","drilled","to","be","critical","parts","of","wells","(","see","#$","Well",")","Generally",",","as","part","of","a","well",",","a","wellbore","will","be","used","either","to","inject","fluid","material","into","the","Earth",",","or","to","extract","fluid","or","gaseous","material","from","the","Earth","."),5303890).
assertion_content_comment('tObjectWellbutrinProduct',s("An","#$","AntiDepressant","drug","product","manufactuered","by","Burroughs","Wellcome","."),1096529).
assertion_content_comment('tObjectWellbutrinSRProduct',s("An","#$","AntiDepressant","drug","product","manufactuered","by","#$","GlaxoInc","."),1098654).
assertion_content_comment('tObjectWellCasing',s("The","collection","of","all","pipes","cemented","in","place","during","the","construction","of","a","well","to","stabilize","the","wellbore","."),3964672).
assertion_content_comment('tObjectWellFlowline',s("A","#$","WellPartType","and","a","subcollection","of","#$","Pipe-ConduitArtifacts",".","#$","WellFlowlines","are","typically","surface","oil","piplines","that","connect","the","#$","Wellhead","to","manifolds","or","production","facilities",".","Flowlines","are","distinct","from","#$","ProductionTubing","."),5556534).
assertion_content_comment('tObjectWellProductionZone',s("A","specialization","of","#$","PathThroughSolid",",","#$","PathArtiface",",","and","|","#$","Underground",",","a","#$","WellProductionZone","is","a","part","of","a","#$","WellBore","at","|","which","various","substances","may","be","produced","(","usually","liquids","or","gases",")"),5549980).
assertion_content_comment('tObjectWellTubing',s("The","collection","of","pipes","run","within","#$","WellCasing","to","transport","fluids","."),3967727).
assertion_content_comment('tObjectWesternClothingStyle',s("the","collection","of","instances","of","#$","SomethingToWear","that","are","in","the","Western","style",".","Western","as","in","cowboy",",","home","on","the","range",",","etc.",",","*","not","*","Western","European","."),1195627).
assertion_content_comment('tObjectWetClayTablet',s("Moist",",","soft","substance","composed","of","very","fine","particles","of","earth","and",",","usually",",","water","."),1073443).
assertion_content_comment('tObjectWetSuit',s("The","collection","of","all","wetsuits",",","which","are","suits","designed","to","protect","sea","divers",",","but","which","are","notdesigned","to","keep","such","divers","dry",".","A","type","of","#$","BodySuit","and","#$","OverGarment",".","The","collection","#$","WetSuit","is","a","#$","SomethingToWearTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3006763).
assertion_content_comment('tObjectWheelbarrow',s("The","collection","of","wheelbarrows","."),1087363).
assertion_content_comment('tObjectWheelchair',s("The","collection","of","all","wheelchairs",",","which","are","chairs","designed","to","be","wheeled","by","the","persons","sitting","on","them","as","a","primary","means","of","locomotion","for","those","persons",".","A","type","of","#$","MobilityAid",",","#$","Device-UserControlled",",","#$","WheeledTransportationDevice",",","#$","SeatingDevice",",","and","#$","SinglePassengerTransportationDevice",".","The","collection","#$","Wheelchair","is","a","#$","TransportationDeviceType",",","a","#$","SpatiallyDisjointObjectType",",","and","an","#$","ArtifactTypeByGenericCategory","."),3006566).
assertion_content_comment('tObjectWheeledAntiTankVehicle',s("The","collection","of","wheeled",",","armored","military","vehicles","with","the","turret","replaced","with","an","anti-tank","missile","platform","."),1088977).
assertion_content_comment('tObjectWheeledTransportationDevice',s("#$","WheeledTransportationDevice","is","a","specialization","of","#$","LandTransportationDevice",".","Each","instance","of","#$","WheeledTransportationDevice","is","a","transportation","device","that","uses","only","wheels","(","as","opposed","to","tracks",",","runners",",","etc.",")","This","collection","includes","not","only","many","instances","of","#$","TransportationDevice-Vehicle",",","but","also","non-self-powered","devices","such","as","#$","Bicycles","and","#$","Wagons","."),1084402).
assertion_content_comment('tObjectWheeledVehicleArmored',s("The","collection","of","all","wheeled","armored","vehicles",".","A","type","of","#$","ArmoredVehicle","and","#$","WheeledTransportationDevice",".","#$","WheeledVehicle-Armored","is","a","#$","SpatiallyDisjointObjectType","."),3007222).
assertion_content_comment('tObjectWhey',s("A","specialization","of","#$","DairyProduct",".","Each","instance","of","#$","Whey","is","some","amount","of","the","watery","liquid","that","separates","from","the","solid","part","of","milk","when","it","turns","sour","or","when","enzymes","are","added","in","cheesemaking","."),1610446).
assertion_content_comment('tObjectWhippedCream',s("An","instance","of","#$","DefaultDisjointEdibleStuffType","and","a","specialization","of","#$","DairyProduct","and","#$","Foam",".","Each","instance","of","#$","WhippedCream","is","a","fluffy",",","white","concoction","made","by","mixing","#$","Cream-Dairy","with","#$","Air","."),1676624).
assertion_content_comment('tObjectWhip',s("The","collection","of","all","whips",".","A","type","of","#$","Device-UserPowered",",","#$","Device-UserControlled",",","and","#$","Device-SingleUser",".","The","collection","#$","Whip","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3007699).
assertion_content_comment('tObjectWhisky',s("The","collection","of","all","whisky",".","A","type","of","#$","Liquor-Drink",".","The","collection","#$","Whisky","is","a","#$","DefaultDisjointEdibleStuffType","and","a","#$","TangibleStuffCompositionType",".","Each","instance","of","#$","Whisky","is","an","alcoholic","beverage","made","by","distilling","fermented","grain",",","such","as","barley",",","rye",",","wheat","or","corn","."),3006246).
assertion_content_comment('tObjectWhistleInstrument',s("The","collection","of","all","tin","whistles",".","A","type","of","#$","Whistle","and","#$","WoodwindInstrument",".","The","concept","#$","Whistle-Instrument","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3009619).
assertion_content_comment('tObjectWhistle',s("The","collection","of","all","whistles",".","A","type","of","#$","Collectible",",","#$","PhysicalDevice",",","and","#$","PortableObject",".","The","collection","#$","Whistle","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3007314).
assertion_content_comment('tObjectWhiteBishopChessPiece',s("A","specialization","of","#$","Bishop-ChessPiece",".","Each","instance","of","#$","WhiteBishop-ChessPiece","is","a","white","chess","piece",".","The","white","player","in","a","game","starts","with","two","white","bishops","."),3688884).
assertion_content_comment('tObjectWhiteBoard',s("A","(","usually","rectangular",")","sheet","of","some","plastic","or","other","composite","material",",","usually","framed","and","supported","by","a","stand","or","hung","on","a","wall",",","for","writing","messages","with","impermanent","markers",".","Popular","in","business/corporate","offices","and","school","rooms","."),1064595).
assertion_content_comment('tObjectWhiteCastelloCheese',s("This","is","the","collection","of","all","instances","of","White","Castello.","|","|","This","is","a","white-mold-crusted","Danish","cheese","shaped","like","a","clover","leaf","with","a","hole","in","|","|","the","middle","."),1099327).
assertion_content_comment('tObjectWhiteChessPiece',s("A","specialization","of","#$","NonPoweredDevice",".","Each","instance","of","#$","ChessPiece","is","an","object","intended","to","be","used","in","a","game","of","chess","as","one","either","a","king",",","queen",",","bishop",",","knight",",","rook","or","pawn","."),3688104).
assertion_content_comment('tObjectWhiteChessPiece',s("A","specialization","of","#$","NonPoweredDevice",".","Each","instance","of","#$","WhiteChessPiece","is","an","object","intended","to","be","used","in","a","game","of","chess","as","either","a","king",",","queen",",","bishop",",","knight",",","rook","or","pawn","of","the","\"","white","\"","player",".","These","pieces","are","traditionally","white",",","but","need","not","be",".","In","any","set","they","must","simply","be","a","different","color","than","the","\"","black","\"","pieces","(","see","#$","BlackChessPiece",")"),3688113).
assertion_content_comment('tObjectWhiteKingChessPiece',s("A","specialization","of","#$","King-ChessPiece",".","Each","instance","of","#$","WhiteKing-ChessPiece","is","a","white","chess","piece",".","The","white","player","in","a","game","starts","with","one","white","king","."),3688887).
assertion_content_comment('tObjectWhiteKnightChessPiece',s("A","specialization","of","#$","Knight-ChessPiece",".","Each","instance","of","#$","WhiteKnight-ChessPiece","is","a","white","chess","piece",".","The","white","player","in","a","game","starts","with","two","white","knights","."),3688894).
assertion_content_comment('tObjectWhitePawnChessPiece',s("A","specialization","of","#$","Pawn-ChessPiece","and","#$","WhiteChessPiece",".","Each","instance","of","#$","WhitePawn-ChessPiece","is","a","white","chess","piece",".","The","white","player","in","a","game","starts","with","eight","white","pawns","."),3688899).
assertion_content_comment('tObjectWhiteRookChessPiece',s("A","specialization","of","#$","Rook-ChessPiece",".","Each","instance","of","#$","WhiteRook-ChessPiece","is","a","chess","piece",".","The","white","player","in","a","game","starts","with","two","white","rooks","."),3688893).
assertion_content_comment('tObjectWhiteWine',s("The","collection","of","all","white","wine",".","A","type","of","#$","Wine",".","The","collection","#$","WhiteWine","is","a","#$","WineTypeByColor","and","an","#$","ExistingStuffType","."),3006486).
assertion_content_comment('tObjectWhiteZinfandel',s("A","specialization","of","#$","BlushWine","."),1536977).
assertion_content_comment('tObjectWickerBasket',s("The","collection","of","all","wicker","baskets",".","A","type","of","#$","Basket",".","The","concept","#$","WickerBasket","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3010189).
assertion_content_comment('tObjectWienerschnitzel',s("The","collection","of","all","wienerschnitzels",".","A","type","of","#$","FoodComposite",".","#$","Wienerschnitzel","is","a","#$","SpatiallyDisjointObjectType","."),3007108).
assertion_content_comment('tObjectWig',s("Fake","hair","worn","on","the","head",".","Made","of","lots","of","chord","shaped","things","(","hairs",")","which","are","sometimes","made","of","real","hair",".","Also","has","a","bottom","piece","which","the","hair","attaches","to",".","This","a","sheet","of","some","stuff","made","of","who","knows","what","."),1109129).
assertion_content_comment('tObjectWikiFarm',s("#$","WikiFarm","is","a","specialization","of","#$","ComputerServer",".","Each","instance","of","#$","WikiFarm","is","a","server","that","runs","an","instance","of","#$","WikiEngine","that","is","available","for","others","to","use","to","develop","their","own","instances","of","#$","WikiWiki","without","configuring","a","#$","WikiEngine","and","a","#$","WorldWideWebServerProgram","themselves","."),1114225).
assertion_content_comment('tObjectWildWeasel',s("The","collection","of","F-4G","#$","MilitaryAircraft","used","mostly","by","the","#$","UnitedStatesOfAmerica","during","Desert","Storm","to","suppress","enemy","air","defense","systems",".","These","aircraft","are","modified","#$","F-4E-Fighters","with","their","cannons","replaced","with","electronic","warfare","equipment","which","detects","and","counteracts","enemy","ground","radar","systems","."),1077006).
assertion_content_comment('tObjectWillAndTestament',s("A","document","containing","a","person","'","s","directions","on","actions","they","wish","taken","after","their","death","."),1099459).
assertion_content_comment('tObjectWin2000Machine',s("A","specialization","of","#$","NTMachine",".","Each","instance","of","this","collection","is","a","#$","Computer","that","runs","(","#$","runsOS",")","some","version","of","#$","MSWindows2000","."),1213953).
assertion_content_comment('tObjectWindbreaker',s("The","collection","of","all","windbreakers",".","A","type","of","#$","Jacket",".","The","collection","#$","Windbreaker","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3007420).
assertion_content_comment('tObjectWindchime',s("The","collection","of","all","windchimes",".","A","type","of","#$","OutdoorAccessoryMarketCategory","and","#$","MechanicalDevice",".","The","concept","#$","Windchime","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3009219).
assertion_content_comment('tObjectWindInstrumentMusical',s("Musical","instruments","into","which","one","blows","air","to","produce","a","sound","."),1106185).
assertion_content_comment('tObjectWindowAirConditioner',s("Window","Unit","air","conditioners"),1098203).
assertion_content_comment('tObjectWindowPane',s("A","specialization","of","#$","PlateGlass",".","Each","instance","of","this","collection","is","a","sheet","of","transparent","material","(","usually","made","of","glass",")","in","a","#$","WindowPortal",".","These","days",",","a","window","generally","has","just","one","window","pane","."),2787266).
assertion_content_comment('tObjectWindowsMachine',s("The","collection","of","all","#$","Computers","that","run","(","#$","runsOS",")","some","version","of","#$","MSWindows","."),1111129).
assertion_content_comment('tObjectWindPoweredDevice',s("#$","WindPoweredDevice","is","a","specialization","of","#$","KineticEnergyPoweredDevice",".","Each","instance","of","#$","WindPoweredDevice","is","powered","by","the","wind",".","Specializations","of","#$","WindPoweredDevice","include","#$","Windmill","and","#$","Sailboat","."),1109269).
assertion_content_comment('tObjectWindPoweredTurbine',s("The","subcollection","of","#$","Turbine","such","that","each","instance","uses","instances","of","#$","Translation-SingleTrajectory","of","instances","of","#$","WindProcess","to","generate","#$","Electricity","."),2400605).
assertion_content_comment('tObjectWindshieldWiperFluid',s("The","fluid","that","squirts","from","your","car","to","clean","the","windshield","(","and","is","sold",")"),1104646).
assertion_content_comment('tObjectWindsock',s("The","collection","of","all","wind","socks",".","A","type","of","#$","OutdoorAccessoryMarketCategory","and","#$","MeasuringDevice",".","The","concept","#$","Windsock","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3009220).
assertion_content_comment('tObjectWindupDevice',s("A","collection","of","physical","devices",";","a","subset","of","#$","MechanicalDevice",".","An","instance","of","#$","WindupDevice","is","powered","by","coiled","springs","through","a","#$","WindingProcess",".","The","coiled","springs","are","tightened","manually","by","winding","a","wheel","or","a","tab",",","#$","CoilTightening",";","the","coiled","spring","slowly","releases","itself","while","it","is","powering","the","#$","WindupDevice",",","otherwise","known","as","#$","CoilLoosening",".","Examples","of","windup","devices","are","watches",",","clocks",",","music","boxes",",","and","toys","."),1100571).
assertion_content_comment('tObjectWindupToy',s("The","collection","of","all","wind","up","toys",".","A","type","of","#$","WindupDevice","and","#$","Toy",".","The","concept","#$","WindupToy","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3009620).
assertion_content_comment('tObjectWineBottle',s("Bottle","in","which","wine","is","packaged","and","stored"),1100847).
assertion_content_comment('tObjectWineCask',s("The","collection","of","all","wine","casks",".","A","type","of","#$","LiquidStorageTank",".","The","collection","#$","WineCask","is","an","#$","ArtifactTypeByFunction","and","a","#$","SpatiallyDisjointObjectType","."),3007856).
assertion_content_comment('tObjectWineDry',s("A","#$","WineTypeBySweetness",".","Each","instance","of","#$","Wine-Dry","is","some","#$","Wine","that","completely","lacks","sweetness","."),1665397).
assertion_content_comment('tObjectWineFullBodied',s("A","#$","WineTypeByBody",".","Each","instance","of","#$","Wine-FullBodied","is","some","#$","Wine","that","is","full-bodied","."),1665470).
assertion_content_comment('tObjectWineGlass',s("Distinctively-shaped","glass","used","for","drinking","wine"),1101071).
assertion_content_comment('tObjectWineHighTannin',s("A","#$","WineTypeByTanninLevel",".","Each","instance","of","#$","Wine-HighTannin","is","some","#$","Wine","that","has","a","high","level","of","tannin",",","or","tannic","acid","."),1665494).
assertion_content_comment('tObjectWineLightBodied',s("A","#$","WineTypeByBody",".","Each","instance","of","#$","Wine-LightBodied","is","some","#$","Wine","that","is","light-bodied","."),1665478).
assertion_content_comment('tObjectWineLowTannin',s("A","#$","WineTypeByTanninLevel",".","Each","instance","of","#$","Wine-LowTannin","is","some","#$","Wine","that","has","a","low","level","of","tannin",",","or","tannic","acid","."),1665502).
assertion_content_comment('tObjectWineMediumBodied',s("A","#$","WineTypeByBody",".","Each","instance","of","#$","Wine-MediumBodied","is","some","#$","Wine","that","is","medium-bodied","."),1665474).
assertion_content_comment('tObjectWineMediumTannin',s("A","#$","WineTypeByTanninLevel",".","Each","instance","of","#$","Wine-MediumTannin","is","some","#$","Wine","that","has","a","medium","level","of","tannin",",","or","tannic","acid","."),1665498).
assertion_content_comment('tObjectWineOffDry',s("A","#$","WineTypeBySweetness",".","Each","instance","of","#$","Wine-OffDry","is","some","#$","Wine","with","very","little","sweetness","."),1665401).
assertion_content_comment('tObjectWineOfRegionFn',s("A","unary","#$","CollectionDenotingFunction","that","takes","a","#$","GeographicalRegion","and","returns","a","#$","WineTypeByRegion",".","","(","#$","WineOfRegionFn","REGION",")","","denotes","the","collection","of","instances","of","#$","Wine","that","were","made","in","","REGION",""),1665383).
assertion_content_comment('tObjectWineOfVintageFn',s("A","unary","#$","CollectionDenotingFunction","that","takes","a","#$","CalendarYear","and","returns","a","#$","WineTypeByVintage",".","","(","#$","WineOfVintageFn","YEAR",")","","denotes","the","collection","of","instances","of","#$","Wine","whose","vintage","(","i.e",".","year","of","harvest",")","is","","YEAR",""),1665339).
assertion_content_comment('tObjectWineOfWineryFn',s("A","unary","#$","CollectionDenotingFunction","that","takes","a","#$","Winery","and","returns","a","#$","WineTypeByWinery",".","","(","#$","WineOfWineryFn","WINERY",")","","denotes","the","collection","of","instances","of","#$","Wine","that","were","made","by","","WINERY",""),1665455).
assertion_content_comment('tObjectWineRack',s("The","collection","of","all","wine","racks",".","A","type","of","#$","Rack-Holder",".","The","concept","#$","WineRack","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3010146).
assertion_content_comment('tObjectWine',s("The","collection","of","all","wine",".","A","type","of","#$","AlcoholicBeverage",".","The","collection","#$","Wine","is","a","#$","DefaultDisjointEdibleStuffType","and","an","#$","ExistingStuffType",".","Each","instance","of","#$","Wine","is","a","portion","of","the","alcoholic","beverage","produced","by","fermenting","crushed","grapes","."),3142918).
assertion_content_comment('tObjectWineSweet',s("A","#$","WineTypeBySweetness",".","Each","instance","of","#$","Wine-Sweet","is","some","#$","Wine","that","significant","sweetness","."),1665405).
assertion_content_comment('tObjectWingTipShoe',s("WingTips","are","mens","lace-up","dress","shoes",".","They","have","wings","pattern","stitched","on","the","uppers","."),1111042).
assertion_content_comment('tObjectWingValvePositionGauge',s("The","collection","of","all","devices","made","to","measure","the","position","of","a","#$","WingValve",".","A","type","of","#$","ValvePositionGauge","."),5629481).
assertion_content_comment('tObjectWingValve',s("A","specialization","of","#$","Valve-Mechanical",".","Wing","valves","are","valves","located","downstream","of","the","tubinghead",",","and","they","are","typically","the","\"","disposable","\"","valves","that","should","be","used","to","initate","a","well","shut-in","."),5629490).
assertion_content_comment('tObjectWinterCoat',s("The","collection","of","#$","Coats","worn","as","#$","OuterGarments",".","One","of","the","main","functions","of","the","#$","WinterCoat","is","to","protect","its","wearer","against","the","cold","."),1055400).
assertion_content_comment('tObjectWinterCoat',s("WinterCoats","are","worn","primarily","for","their","warmth","."),812187).
assertion_content_comment('tObjectWinterHeadgear',s("The","collection","of","all","winter","hats",".","A","type","of","#$","WarmClothes","and","#$","Headgear",".","The","collection","#$","WinterHeadgear","is","a","#$","SeasonallyUsedItemType",",","a","#$","SpatiallyDisjointObjectType",",","and","a","#$","SomethingToWearTypeByGenericCategory","."),3008097).
assertion_content_comment('tObjectWinterOnlyPathArtifact',s("#$","WinterOnly-PathArtifact","is","the","collection","of","instances","of","|","|","#$","PathForWheeledVehicles","that","are","open","for","intended","users","only","during","winter","|","|","months","of","frozen","ground","or","water","conditions","."),1195010).
assertion_content_comment('tObjectWireCutter',s("The","collection","of","all","wire","cutters",".","A","type","of","#$","CuttingDevice",",","#$","HandTool",",","and","#$","IndustrialEquipment",".","The","collection","#$","WireCutter","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3008151).
assertion_content_comment('tObjectWireGrill',s("A","standard","grill",",","more","or","less","2-D",",","made","of","metal","bars","arranged","in","a","lattice","or","as","slats","."),1102749).
assertion_content_comment('tObjectWirelessAccessPointDevice',s("Electronic","devices","which","allow","connection","to","a","wireless","network",".","These","may","be","dedicated","access","point","devices","or","combination","devices","that","allow","a","variety","of","connections","."),4575035).
assertion_content_comment('tObjectWirelessCommunicationDevice',s("The","collection","of","|","|","#$","CommunicationDevices","in","which","the","communication","signals","are","either","not","transmitted","or","not","received","entirely","over","a","wire","."),1105714).
assertion_content_comment('tObjectWirelessCommunicationDevice',s("This","needs","more","work","."),563942).
assertion_content_comment('tObjectWirelessLANController',s("The","collection","of","all","wireless","LAN","controllers","."),5022721).
assertion_content_comment('tObjectWirelessRouter',s("The","collection","of","all","routers","designed","for","use","with","WiFi","or","other","wireless","systems","."),4575090).
assertion_content_comment('tObjectWireline',s("A","specialization","of","#$","PhysicalDevice","and","an","instance","of","#$","WellPartType",".","Instances","in","this","collection","are","used","in","#$","WirelineOperation","events","."),5222896).
assertion_content_comment('tObjectWire',s("A","collection","of","physical","devices",",","namely","all","the","slender","stringlike","pieces","of","metal",",","with","or","without","insulative","casing",".","Various","instances","of","#$","Wire","are","designed","for","and","serve","many","different","functions",":","connecting",",","carrying","electrical","power","and/or","electrically","coded","information",",","heat","or","light","radiation",",","etc",".","Pieces","of","wire","may","be","coated","with","insulation","(","instances","of","#$","InsulatingCover",")","Wires","not","intended","to","carry","electricity","are","still","instances","of","this","collection",";","e.g.",",","wires","that","are","used","in","a","piano",",","in","a","person","'","s","dental","braces",",","etc","."),1105543).
assertion_content_comment('tObjectWireWhisk',s("A","wire","utensil","usually","used","to","beat","eggs","or","mix","batter","."),1105690).
assertion_content_comment('tObjectWitchHat',s("The","collection","of","all","witch","hats",".","A","type","of","#$","Hat",".","The","collection","#$","WitchHat","is","a","#$","SomethingToWearTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3008016).
assertion_content_comment('tObjectWithdrawalSlip',s("A","collection","of","#$","InformationBearingObjects",".","A","instance","of","#$","WithdrawalSlip","is","a","form","[","#$","Form-StandardizedIBO","]","filled","out","by","a","person","making","a","withdrawal","from","a","bank",",","requesting","the","specifics","of","that","withdrawal","."),1103838).
assertion_content_comment('tObjectWithUse',s("A","collection","of","tangible","things","that","have","clear","intended","behavior","or","purpose",".","An","important","subcollection","is","#$","PhysicalDevice","that","consists","of","things","made","or","modified","for","some","particular","purpose",".","#$","ObjectWithUse",",","however",",","is","meant","to","include","the","members","of","collections","such","as","#$","Horse","(","and","some","other","subcollections","of","#$","Animal",")","that","are","intended","for","transportation","(","at","least","in","some","contexts",")","Also",",","an","#$","ObjectWithUse","need","not","have","a","relatively","rigid",",","set","shape",",","so","#$","GasolineFuel","or","#$","AntiFreeze","are","subsets","of","#$","ObjectWithUse","."),1074291).
assertion_content_comment('tObjectWokCookingPot',s("The","collection","of","all","woks",".","A","type","of","#$","CookingVessel","and","#$","ManufacturedGoods",".","The","collection","#$","Wok-CookingPot","is","a","#$","ManufacturedGoodsType",",","a","#$","SpatiallyDisjointObjectType",",","and","an","#$","ArtifactTypeByGenericCategory","."),3008835).
assertion_content_comment('tObjectWomensBag',s("The","collection","of","all","women","'","s","handbags",".","A","type","of","bag","used","by","women",".","The","collection","#$","WomensBag","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3007039).
assertion_content_comment('tObjectWomensClothing',s("A","specialization","of","#$","Clothing-Generic",".","Each","specialization","of","#$","WomensClothing","is","a","type","of","clothing","item","worn","usually","by","women",".","Specializations","of","#$","WomensClothing","include","#$","Bra",",","#$","Dress",",","and","#$","Skirt","."),1107905).
assertion_content_comment('tObjectWomensDressBoot',s("Formal","shoes","worn","by","women","."),1110756).
assertion_content_comment('tObjectWomensHosiery',s("The","collection","of","all","stockings"),1051272).
assertion_content_comment('tObjectWomensShoe',s("The","collection","of","shoes","designed","to","be","worn","by","women","and","not","by","men","."),1109045).
assertion_content_comment('tObjectWomensToteBag',s("The","collection","of","all","totes",".","A","type","of","#$","WomensBag",".","The","collection","#$","WomensToteBag","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3007379).
assertion_content_comment('tObjectWomensUnderpants',s("The","collection","of","all","women","'","s","underpants",".","A","type","of","#$","Underpants","and","#$","Lingerie",".","The","collection","#$","WomensUnderpants","is","a","#$","SomethingToWearTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3006875).
assertion_content_comment('tObjectWoodCuttingCircularSawBlade',s("The","collection","of","blades","for","many","types","of","#$","PowerSaws",".","Each","is","relatively","flat",",","circular","in","shape",",","and","with","teeth","all","around","the","edge",".","A","hole","at","the","center","allows","the","blade","to","be","mounted","on","the","arbor","of","the","saw",",","which","transmits","the","spinning","force","from","the","motor","to","the","blade","when","the","saw","is","turned","on","."),4750138).
assertion_content_comment('tObjectWoodenPencil',s("The","pencil","that","we","use","to","write","on","paper","."),1103818).
assertion_content_comment('tObjectWoodenSpoon',s("a","spoon","made","of","wood","used","for","cooking","."),1094696).
assertion_content_comment('tObjectWoodenStake',s("A","specialization","of","#$","Stake",".","Each","instance","of","this","collection","is","a","stake","made","of","wood","."),1402480).
assertion_content_comment('tObjectWoodGolfClub',s("golf","clubs","with","large","heads","on","them",",","usually","made","of","wood",",","which","are","used","for","hitting","the","ball","very","long","distances","with","less","accuracy","than","with","an","iron","club"),1082798).
assertion_content_comment('tObjectWoodLathe',s("A","type","of","#$","StationaryTool","used","for","shaping","pieces","of","#$","Wood","subtractively","in","a","manner","that","is","symmetric","about","an","axis","of","rotation",".","Instances","of","#$","WoodLathe","allow","the","workpiece","to","be","mounted","and","spun","at","relatively","high","speed",",","while","a","(","typically",")","hand-held","cutting","tool","is","controlled","by","an","operator","to","remove","material","from","the","workpiece",".","Wood","cutting","lathes","usually","have","a","tool","rest","to","make","it","easier","to","control","hand-held","cutting","tools","."),4751706).
assertion_content_comment('tObjectWoodPaneling',s("The","collection","of","all","wood","paneling",".","A","type","of","#$","Artifact",".","#$","WoodPaneling","is","a","#$","SpatiallyDisjointObjectType","."),3010513).
assertion_content_comment('tObjectWoodScrew',s("The","collection","of","all","screws","which","are","#$","PointyEnded","and","have","threads","designed","to","bite","into","#$","Wood","."),4753825).
assertion_content_comment('tObjectWoodSculpture',s("WoodSculptures","as","art","forms"),1110117).
assertion_content_comment('tObjectWoodStain',s("Liquid","applied","to","wood","in","order","to","change","its","color","."),1094429).
assertion_content_comment('tObjectWoodturningTool',s("The","collection","of","all","#$","HandTools","designed","to","be","used","with","a","#$","WoodLathe","to","shape","#$","Wood",".","Example","specializations","include","the","roughing","gouge",",","the","skew","chisel","and","the","parting","tool","."),4752994).
assertion_content_comment('tObjectWoodwindInstrument',s("Musical","instruments","using","reeds","or","flute/whistle-type","mechanisms","to","produce","sound","."),1105962).
assertion_content_comment('tObjectWoodworkingChisel',s("The","collection","of","all","#$","Chisels","designed","to","cut","#$","Wood",",","but","also","suitable","for","shaping","materials","of","similar","or","lesser","hardness",",","such","as","many","types","of","#$","Plastic","."),4749159).
assertion_content_comment('tObjectWoodworkingTool',s("Tools","used","to","shape",",","join",",","and","cut","wood",",","where","the","wood","itself","is","or","forms","the","desired","object",".","Includes","both","chisels","and","the","hammers","used","to","drive","the","chisels",";","power","routers",",","sanders",",","saws",",","etc",".","Does","not","include","nail","guns","or","other","carpentry","tools","where","the","wood","is","simply","an","included","part","of","a","larger","structure",".","These","tools/devices","are","capable","of","being","used","and","are","designed","to","be","used","on","wood",",","but","this","doesn","'","t","preclude","their","use","on","other","types","of","materials","(","having","similar","textures",",","properties",",","etc.",")","for","which","they","might","be","suited","."),1057064).
assertion_content_comment('tObjectWoodwork',s("The","collection","of","#$","Wood","#$","Artifacts"),1104284).
assertion_content_comment('tObjectWoolCloth',s("Cloth","made","out","of","wool","fibers","."),1104265).
assertion_content_comment('tObjectWorkBench',s("A","large",",","sturdy","table","upon","which","devices","get","fixed","using","tools"),1096756).
assertion_content_comment('tObjectWorkLocationKey',s("A","key","that",",","when","functioning","properly",",","lets","its","user","unlock","a","door","to","his/her","place","of","employment",".","Some","electronic","versions","of","#$","WorkLocationKey","can","be","disabled","by","whomever","has","control","of","the","#$","DoorLock","(","typically","the","employer",")","even","if","they","do","not","have","physical","control","of","the","key","."),1418965).
assertion_content_comment('tObjectWorksOfArtFromFn',s("(","#$","WorksOfArtFromFn","GEO-THING",")","denotes","the","collection","of","objects","of","|","|","art","that","come","from","GEOO-THING",",","an","instance","of","#$","GeographicalThing","."),1074927).
assertion_content_comment('tObjectWorksOfArtPeriodFn',s("(","#$","WorksOfArtPeriodFn","PERIOD",")","denotes","the","collection","of","objects","|","of","art","that","belong","to","PERIOD",",","a","certain","period","ofently","noted","by","historian","|","of","art","."),1073444).
assertion_content_comment('tObjectWorkStation',s("A","permanent","or","semi-permanent","arrangement","with","a","device","and","facilities","for","working","on","that","device",".","Includes","cash","register","stations",",","check","out","counters",",","milling","machine","stations",",","kitchen","top","region","(","with","all","the","gadgets",")",","),1100498).
assertion_content_comment('tObjectWorkVisaDocument',s("A","specialization","of","Visa-Document",".","Each","instance","of","Visa-Document","is","a","document","issued","by","the","government","of","some","country","to","one","(","or","more",")","person","(","s",")",",","authorizing","that","person","(","or","those","persons",")","to","enter","that","country","and","remain","for","a","certain","period","of","time","while","engaging","in","work","."),1337468).
assertion_content_comment('tObjectWorldWideWebPageCopy',s("#$","WorldWideWebPageCopy","is","the","collection","of","all","copies","of","instances","of","#$","WorldWideWebPage-AIS","."),1080902).
assertion_content_comment('tObjectWoven',s("Woven","like","fabric","."),1189402).
assertion_content_comment('tObjectWrapClothing',s("The","collection","of","all","wraps",".","A","type","of","#$","ClothingItem",".","The","collection","#$","Wrap-Clothing","is","a","#$","SomethingToWearTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3008017).
assertion_content_comment('tObjectWrapper',s("The","collection","of","pieces","of","sheet-like","material","that","become","containers","when","they","are","wrapped","around","objects",".","Examples","include","shrink-wrap","packages","and","candy","bar","wrappers","."),1106029).
assertion_content_comment('tObjectWrapSandwich',s("The","collection","of","all","sandwich","wraps",".","A","type","of","#$","Sandwich",".","#$","Wrap-Sandwich","is","a","#$","SpatiallyDisjointObjectType","."),3006618).
assertion_content_comment('tObjectWreckerTruck',s("A","#$","RoadVehicleTypeByUse",".","Each","instance","of","#$","WreckerTruck","is","a","#$","Truck","used","for","towing","disabled","or","damaged","#$","RoadVehicles","."),335074).
assertion_content_comment('tObjectWrench',s("A","tool","used","for","rotating","things","like","bolts"),1099816).
assertion_content_comment('tObjectWrestlingRing',s("The","collection","of","all","wrestling","rings",".","A","type","of","#$","SportsRing",".","#$","WrestlingRing","is","a","#$","SpatiallyDisjointObjectType","."),3009885).
assertion_content_comment('tObjectWrestlingShoe',s("The","collection","of","all","wrestling","shoes"),1101417).
assertion_content_comment('tObjectWrinkleRemovingDevice',s("The","class","of","appliances",",","including","#$","ClothesIrons","and","#$","ClothesSteamers",",","which","are","intended","to","be","used","to","remove","wrinkles","from","textiles","."),1098672).
assertion_content_comment('tObjectWristGuard',s("The","collection","of","all","wrist","guards",",","which","are","devices","intended","to","be","worn","to","protect","wrists",".","A","type","of","#$","ProtectiveAttire",",","#$","SportsEquipment",",","and","#$","PhysicalImpactBuffer",".","The","collection","#$","WristGuard","is","a","#$","SomethingToWearTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3006832).
assertion_content_comment('tObjectWristwatch',s("The","collection","of","all","wrist","watches",",","which","are","watches","designed","to","be","worn","on","wrists",".","A","type","of","#$","Watch",",","#$","SelfPoweredDevice",",","and","#$","SomethingToWear",".","The","collection","#$","Wristwatch","is","an","#$","ArtifactTypeByGenericCategory","and","a","#$","SpatiallyDisjointObjectType","."),3006734).
assertion_content_comment('tObjectWritePermission',s("#$","WritePermission","is","one","of","the","three","#$","FilePermissions",".","If","an","account","has","#$","WritePermission","for","a","file",",","it","can","legitimately","alter","the","information","on","that","file","."),1076751).
assertion_content_comment('tObjectWritingBoard',s("A","(","usually","rectangular",")","sheet","of","some","composite","material",",","usually","framed","and","supported","by","a","stand","or","hung","on","a","wall",",","for","writing","messages",".","Popular","in","business/corporate","offices","and","school","rooms","."),1086587).
assertion_content_comment('tObjectWritingDesk',s("The","collection","of","writing","desks","--","smallish","desks","intended","to","support","the","activity","of","#$","Writing",".","Writing","desks","often","have","small","storage","compartments","and","a","folding","cover","."),5214784).
assertion_content_comment('tObjectWritingImplement',s("#$","WritingImplement","is","a","specialization","of","#$","StationeryProduct","and","#$","HandTool",".","Each","instance","of","#$","WritingImplement","is","a","hand-held","tool","which","is","intended","to","be","primarily","used",",","by","a","person",",","for","writing",".","Specializations","include","the","collections","#$","Chalk-WritingImplement","and","#$","WritingPen","(","but","not","#$","Typewriter",")"),1099138).
assertion_content_comment('tObjectWritingPen',s("A","specialization","of","#$","WritingImplement",".","Each","instance","is","a","stick","with","a","point","at","one","end","which","can","transmit","ink","to","a","writing","surface","."),1858240).
assertion_content_comment('tObjectWritingSurfaceProduct',s("Kinds","of","objects","produced","to","serve","as","a","writing","surfaces",",","surfaces","on","which","marking","are","intentionally","made","to","communicate","."),1084449).
assertion_content_comment('tObjectWritOfCertioriLegalDocument',s("The","collection","of","all","physical","#$","LegalDocuments","such","that","each","instance","enacts","a","#$","WritOfCertiori-PCW",".","Such","a","document","is","ordinarily","created","at","the","direction","of","the","#$","UnitedStatesSupremeCourt","when","#$","IssuingAWritOfCertiori",",","as","part","of","the","procedure","by","which","the","court","agrees","to","hear","a","case","that","has","been","appealed","to","it","."),2991768).
assertion_content_comment('tObjectWuYiSupportShip',s("A","class","of","|","|","#$","SupportShip","currently","(","2000",")","|","|","used","by","|","|","#$","Taiwan-RepublicOfChina","."),581682).
assertion_content_comment('tObjectWZ501ArmoredFightingVehicle',s("Class","of","|","|","#$","ArmoredFightingVehicle","currently","(","2000",")","used","by","#$","China-PeoplesRepublic","."),568144).
assertion_content_comment('tObjectWZ551ArmoredFightingVehicle',s("Class","of","|","|","#$","ArmoredFightingVehicle","currently","(","2000",")","used","by","#$","China-PeoplesRepublic","."),568178).
assertion_content_comment('tObjectWZ553ArmoredPersonnelCarrier',s("Class","of","|","|","#$","ArmoredPersonnelCarrier","currently","(","2000",")","used","by","#$","China-PeoplesRepublic","."),568166).
assertion_content_comment('tObjectXenical',s("A","lipase","inhibitor","commonly","used","for","weight","loss",";","manufactured","by","Roche","."),1102625).
assertion_content_comment('tObjectXIAClassSubmarine',s("A","class","of","nuclear","powered","ballistic","missile","|","|","submarines","used","by","#$","China-PeoplesRepublic","."),568416).
assertion_content_comment('tObjectXPMachine',s("The","collection","of","all","#$","Computers","that","run","(","#$","runsOS",")","some","version","of","#$","MSWindowsXP",".","See","also","#$","Win2000Machine",",","#$","NTMachine","and","#$","WindowsMachine","."),1214527).
assertion_content_comment('tObjectXPMachine',s("This","is","a","spec","of","#$","NTMachine",",","as","#$","MSWindowsXP","is","apparently","'","Windows","NT","version","5.1","'"),1214524).
assertion_content_comment('tObjectXRayPhotographicDevice',s("The","collection","of","machines","intended","for","taking","still","X-ray","photos","of","something",",","usually","a","BLO","."),1095981).
assertion_content_comment('tObjectXT_69A1_SPArtilleryVehicle',s("A","class","of","instances","of","|","|","#$","Artillery-SelfPropelled","currently","(","2000",")","|","|","owned","by","#$","Taiwan-RepublicOfChina","."),568303).
assertion_content_comment('tObjectXT_69_SPArtilleryVehicle',s("A","class","of","instances","of","|","|","#$","Artillery-SelfPropelled","currently","(","2000",")","|","|","owned","by","#$","Taiwan-RepublicOfChina","."),568308).
assertion_content_comment('tObjectXylophone',s("A","type","of","percussion","instrument","made","of","wooden","bars","and","played","with","|","|","small","mallets","."),1101493).
assertion_content_comment('tObjectYacht',s("The","collection","of","all","yachts",".","A","type","of","#$","Sailboat",".","#$","Yacht","is","a","#$","SpatiallyDisjointObjectType","."),3008018).
assertion_content_comment('tObjectYamahaMotorcycle',s("The","collection","of","all","motorcycles","manufactured","by","the","Yamaha","company",".","A","type","of","#$","Motorcycle",".","#$","YamahaMotorcycle","is","a","#$","MotorcycleTypeByBrand","and","a","#$","SpatiallyDisjointObjectType","."),3033076).
assertion_content_comment('tObjectYangClassDestroyer',s("A","class","of","|","|","#$","Destroyer","used","by","#$","Taiwan-RepublicOfChina","."),575417).
assertion_content_comment('tObjectYarn',s("A","type","of","cordlike","textile","larger","in","diameter","than","thread",".","Used","for","knitting","and","weaving","."),1106176).
assertion_content_comment('tObjectYellowMustard',s("A","specialization","of","#$","Mustard-ThePreparation",".","Yellow","mustard","is","the","most","common","mustard","in","the","US",".","It","is","smooth","and","bright","yellow","."),4441991).
assertion_content_comment('tObjectYieldSign',s("The","collection","of","all","yield","signs",".","A","type","of","#$","StationarySign","and","#$","RoadSign",".","#$","YieldSign","is","a","#$","SpatiallyDisjointObjectType","."),3010150).
assertion_content_comment('tObjectYogurt',s("Yogurt","is","a","dairy","product","containing","active","yogurt","cultures","which","digest","the","lactose","and","make","the","yogurt","more","easily","digestible","for","us","humans","."),1094811).
assertion_content_comment('tObjectYoYo',s("The","collection","of","inexpensive","toys","made","of","a","spool","and","a","|","string","that","winds","and","unwinds","around","and","from","around","it","as","it","is","|","dropped","from","the","hand","of","a","player","and","rebounds","."),1104512).
assertion_content_comment('tObjectYuanwanSupportShip',s("A","class","of","#$","SupportShip","currently","(","2000",")","|","|","used","by","#$","China-PeoplesRepublic","."),581479).
assertion_content_comment('tObjectYugoCar',s("The","collection","of","all","Yugo","cars",".","A","type","of","#$","YugoslavianCar",".","The","collection","#$","YugoCar","is","an","#$","AutomobileTypeByBrand","and","a","#$","SpatiallyDisjointObjectType","."),3007815).
assertion_content_comment('tObjectYungChouSupportWatercraft',s("A","class","of","support","watercraft","currently","(","2000",")","|","|","used","by","|","|","#$","Taiwan-RepublicOfChina","."),581636).
assertion_content_comment('tObjectYungFungSupportWatercraft',s("A","class","of","support","watercraft","currently","(","2000",")","|","|","used","by","|","|","#$","Taiwan-RepublicOfChina","."),581627).
assertion_content_comment('tObjectYungYangSupportWatercraft',s("A","class","of","support","watercraft","currently","(","2000",")","|","|","used","by","|","|","#$","Taiwan-RepublicOfChina","."),581621).
assertion_content_comment('tObjectYuTaiSupportShip',s("A","class","of","|","|","#$","SupportShip","currently","(","2000",")","|","|","used","by","|","|","#$","Taiwan-RepublicOfChina","."),581654).
assertion_content_comment('tObjectYW534ArmoredPersonnelCarrier',s("Class","of","|","|","#$","ArmoredPersonnelCarrier","currently","(","2000",")","used","by","#$","China-PeoplesRepublic","."),568156).
assertion_content_comment('tObjectZeppelin',s("The","collection","of","all","zeppelins",".","A","type","of","#$","LighterThanAirCraft",".","#$","Zeppelin","is","a","#$","SpatiallyDisjointObjectType","."),3009221).
assertion_content_comment('tObjectZerit',s("The","collection","of","all","Zerit",".","A","type","of","#$","DrugProduct",".","#$","Zerit","is","a","#$","NucleosideReverseTrancriptaseInhibitorDrugClass","and","a","#$","BrandNamePharmacyProductType","."),3010151).
assertion_content_comment('tObjectZiagen',s("The","collection","of","all","Ziagen",".","A","type","of","#$","Abacavir",".","#$","Ziagen","is","a","#$","NucleosideReverseTrancriptaseInhibitorDrugClass","and","a","#$","BrandNamePharmacyProductType","."),3008153).
assertion_content_comment('tObjectZinfandelWine',s("A","#$","WineTypeByGrapeType",".","Each","instance","of","#$","Zinfandel-Wine","is","some","#$","Wine","made","with","Zinfandel","grapes","."),590137).
assertion_content_comment('tObjectZipperTheFastener',s("Any","kind","of","zipper","."),1103814).
assertion_content_comment('tObjectZPU_4MachineGun',s("A","large","machine","gun","used","for","air","defense","."),1070289).
assertion_content_comment('tObjectZyban',s("The","colleciton","of","drug","products","called","#$","Zyban","designed","to","help","users","quit","smoking",".","Zyabn","does","not","control","#$","Nicotine","."),1071783).
assertion_content_comment('tOblateSpheroidalSolid',s("A","specialization","of","#$","SpheroidalSolid","(","q.v.",")","Each","instance","of","#$","OblateSpheroidalSolid","is","a","(","tangible","or","intangible",")","three-dimensional","object","whose","boundary","is","or","approximates","an","#$","OblateSpheroid","(","q.v.",")","Thus",",","its","equatorial","diameter","is","greater","than","its","polar","diameter.","|","
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","|","Cf",".","#$","ProlateSpheroidalSolid","and","#$","SphericalSolid","."),2069205). assertion_content_comment('tOblateSpheroid',s("A","specialization","of","#$","Spheroid","(","q.v.",")","Each","instance","of","#$","OblateSpheroid","is","a","\"","squashed","\"","spheroid",":","one","whose","polar","radius","is","less","than","its","equatorial","radius","(","see","#$","polarRadiusOfSpheroid","and","#$","equatorialRadiusOfSpheroid",")","|","
","|","Cf",".","#$","ProlateSpheroid","."),1974613). assertion_content_comment('tOboGo_A1AdenosineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","A1","adenosine","receptor","."),4322451). assertion_content_comment('tOboGo_A2AAdenosineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","A2A","adenosine","receptor","."),4322501). assertion_content_comment('tOboGo_A2BAdenosineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","A2B","adenosine","receptor","."),4322511). assertion_content_comment('tOboGo_A3AdenosineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","A3","adenosine","receptor","."),4322491). assertion_content_comment('tOboGo_ABand',s("The","dark-staining","region","of","a","sarcomere",",","in","which","myosin","thick","filaments","are","present",";","the","center","is","traversed","by","the","paler","H","zone",",","which","in","turn","contains","the","M","line","."),4039687). assertion_content_comment('tOboGo_AbaxialCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","abaxial","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4334020). assertion_content_comment('tOboGo_AbducensNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","abducens","nerve","over","time",",","from","its","formation","to","the","mature","structure",".","The","motor","function","of","the","abducens","nerve","is","to","contract","the","lateral","rectus","which","results","in","abduction","of","the","eye","."),4044656). assertion_content_comment('tOboGo_AbducensNerveFormation',s("The","process","that","gives","rise","to","the","abducens","nerve",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","motor","function","of","the","abducens","nerve","is","to","contract","the","lateral","rectus","which","results","in","abduction","of","the","eye","."),4044682). assertion_content_comment('tOboGo_AbducensNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","abducens","nerve","to","attain","its","fully","functional","state",".","The","motor","function","of","the","abducens","nerve","is","to","contract","the","lateral","rectus","which","results","in","abduction","of","the","eye","."),4044707). assertion_content_comment('tOboGo_AbducensNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","abducens","nerve","is","generated","and","organized",".","The","motor","function","of","the","abducens","nerve","is","to","contract","the","lateral","rectus","which","results","in","abduction","of","the","eye","."),4044670). assertion_content_comment('tOboGo_AbducensNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","abducens","nerve",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","motor","function","of","the","abducens","nerve","is","to","contract","the","lateral","rectus","which","results","in","abduction","of","the","eye","."),4044695). assertion_content_comment('tOboGo_AbducensNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","abducens","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042865). assertion_content_comment('tOboGo_AbequosyltransferaseActivity',s("Catalysis","of","the","reaction",":","CDP-abequose","+","D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid","=","CDP","+","D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid","."),4372984). assertion_content_comment('tOboGo_AbietadieneSynthaseActivity',s("Catalysis","of","the","reaction",":","(","+",")","-copalyl","diphosphate","=","(","-",")","-abietadiene","+","diphosphate","."),4268098). assertion_content_comment('tOboGo_AbortiveMitoticCellCycle',s("A","cell","cycle","in","which","mitosis","is","begun","and","progresses","normally","through","the","end","of","anaphase",",","but","not","completed",",","resulting","in","a","cell","with","increased","ploidy","."),4337774). assertion_content_comment('tOboGo_AbscisicAcidBinding',s("Interacting","selectively","and","non-covalently","with","abscisic","acid",",","plant","hormones","that","regulate","aspects","of","plant","growth","."),4333438). assertion_content_comment('tOboGo_AbscisicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","abscisic","acid",",","5-","(","1-hydroxy-2",",","6",",","6",",","trimethyl-4-oxocyclohex-2-en-1-y1",")","-3-methylpenta-2",",","4-dienoic","acid","."),4032882). assertion_content_comment('tOboGo_AbscisicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","abscisic","acid",",","5-","(","1-hydroxy-2",",","6",",","6",",","trimethyl-4-oxocyclohex-2-en-1-y1",")","-3-methylpenta-2",",","4-dienoic","acid","."),4350107). assertion_content_comment('tOboGo_AbscisicAcidGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","(","+",")","-abscisate","+","UDP-D-glucose","=","abscisic","acid","glucose","ester","+","UDP","."),4335161). assertion_content_comment('tOboGo_AbscisicAcidMediatedSignalingPathway',s("A","series","of","molecular","signals","mediated","by","the","detection","of","abscisic","acid","."),4022468). assertion_content_comment('tOboGo_AbscisicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","abscisic","acid",",","5-","(","1-hydroxy-2",",","6",",","6",",","trimethyl-4-oxocyclohex-2-en-1-y1",")","-3-methylpenta-2",",","4-dienoic","acid","."),4032861). assertion_content_comment('tOboGo_AbscisicAcidTransport',s("The","directed","movement","of","abscisic","acid","into",",","out","of",",","within","or","between","cells","by","means","of","some","external","agent","such","as","a","transporter","or","pore","."),4181206). assertion_content_comment('tOboGo_AbscisicAldehydeOxidaseActivity',s("Catalysis","of","the","reaction",":","(","+",")","-abscisic","aldehyde","+","H","(","2",")","O","+","O","(","2",")","=","abscisate","+","H","(","2",")","O","(","2",")","+","H","(","+",")"),4335148). assertion_content_comment('tOboGo_Abscission',s("The","controlled","shedding","of","a","body","part","."),4021567). assertion_content_comment('tOboGo_AbsorptionOfUVLight',s("The","reception","of","a","(","UV","light",")","photon","by","a","cell",",","UV","light","being","defined","as","having","a","wavelength","within","the","range","13.6-400","nm","."),4302661). assertion_content_comment('tOboGo_AbsorptionOfVisibleLight',s("The","reception","of","a","(","visible","light",")","photon","by","a","cell",",","visible","light","being","defined","as","having","a","wavelength","within","the","range","380-780","nm","."),4302671). assertion_content_comment('tOboGo_AcceptanceOfPollen',s("The","process",",","involving","the","sharing","and","interaction","of","the","single","locus","incompatibility","haplotypes",",","involved","in","the","acceptance","of","pollen","by","cells","in","the","stigma","."),4160511). assertion_content_comment('tOboGo_AccessoryNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","accessory","nerve","over","time",",","from","its","formation","to","the","mature","structure",".","In","mice",",","the","spinal","branch","of","this","motor","nerve","innervates","the","trapezius","and","the","sternocleidomastoid","muscles",".","The","cranial","branch","joins","the","vagus","nerve","and","innervates","the","same","targets","as","the","vagus","nerve","."),4044718). assertion_content_comment('tOboGo_AccessoryNerveFormation',s("The","process","that","gives","rise","to","the","accessory","nerve",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","spinal","branch","of","this","motor","nerve","innervates","the","trapezius","and","the","sternocleidomastoid","muscles",".","The","cranial","branch","joins","the","vagus","nerve","and","innervates","the","same","targets","as","the","vagus","nerve","."),4044758). assertion_content_comment('tOboGo_AccessoryNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","accessory","nerve","to","attain","its","fully","functional","state",".","The","spinal","branch","of","this","motor","nerve","innervates","the","trapezius","and","the","sternocleidomastoid","muscles",".","The","cranial","branch","joins","the","vagus","nerve","and","innervates","the","same","targets","as","the","vagus","nerve","."),4044733). assertion_content_comment('tOboGo_AccessoryNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","accessory","nerve","is","generated","and","organized",".","The","spinal","branch","of","this","motor","nerve","innervates","the","trapezius","and","the","sternocleidomastoid","muscles",".","The","cranial","branch","joins","the","vagus","nerve","and","innervates","the","same","targets","as","the","vagus","nerve","."),4044746). assertion_content_comment('tOboGo_AccessoryNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","accessory","nerve","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","spinal","branch","of","this","motor","nerve","innervates","the","trapezius","and","the","sternocleidomastoid","muscles",".","The","cranial","branch","joins","the","vagus","nerve","and","innervates","the","same","targets","as","the","vagus","nerve","."),4044797). assertion_content_comment('tOboGo_AccumulationOfOxidativelyModifiedProteinsInvolvedInReplicativeCellAging',s("Accumulation","of","proteins","that","have","undergone","reactions","with","reactive","oxygen","species","in","aging","dividing","cells","and","exhibit","modifications","such","as","increased","protein","carbonyl","content",",","oxidized","methionine",",","protein","hydrophobicity",",","and","cross-linking","."),3980126). assertion_content_comment('tOboGo_AcetaldehydeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","acetaldehyde",",","a","colorless",",","flammable","liquid","intermediate","in","the","metabolism","of","alcohol","."),4351642). assertion_content_comment('tOboGo_AcetaldehydeCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetaldehyde",",","a","colorless",",","flammable","liquid","intermediate","in","the","metabolism","of","alcohol","."),4351628). assertion_content_comment('tOboGo_AcetaldehydeDehydrogenaseAcetylatingActivity',s("Catalysis","of","the","reaction",":","acetaldehyde","+","CoA","+","NAD","+","=","acetyl-CoA","+","NADH","+","H","+"),4251859). assertion_content_comment('tOboGo_AcetaldehydeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acetaldehyde",",","a","colorless",",","flammable","liquid","intermediate","in","the","metabolism","of","alcohol","."),4224336). assertion_content_comment('tOboGo_AcetateBiosyntheticProcessFromCarbonMonoxide',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","acetate","from","other","compounds",",","including","carbon","monoxide","."),4240710). assertion_content_comment('tOboGo_AcetateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","acetate",",","the","anion","of","acetic","acid","."),4240684). assertion_content_comment('tOboGo_AcetateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate",",","the","anion","of","acetic","acid","."),4086606). assertion_content_comment('tOboGo_AcetateCatabolicProcessToButyrateEthanolAcetoneAndButanol',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate","to","form","butyrate",",","ethanol",",","acetone","and","butanol","."),4334489). assertion_content_comment('tOboGo_Acetate_CationSymporterActivity',s("Catalysis","of","the","transfer","of","acetate","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","acetate","(","out",")","+","cation","(","out",")","=","acetate","(","in",")","+","cation","(","in",")"),4295942). assertion_content_comment('tOboGo_AcetateDerivativeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","derivatives","of","acetic","acid","."),4262388). assertion_content_comment('tOboGo_AcetateDerivativeCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","derivatives","of","acetic","acid","."),4308171). assertion_content_comment('tOboGo_AcetateDerivativeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","derivatives","of","acetic","acid","."),4026495). assertion_content_comment('tOboGo_AcetateFermentation',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate",",","yielding","energy","in","the","form","of","ATP","."),4244307). assertion_content_comment('tOboGo_Acetate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","acetate","(","out",")","+","H","+","(","out",")","=","acetate","(","in",")","+","H","+","(","in",")"),4295951). assertion_content_comment('tOboGo_AcetateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","acetate","=","ADP","+","acetyl","phosphate","."),4251891). assertion_content_comment('tOboGo_AcetateKinaseDiphosphateActivity',s("Catalysis","of","the","reaction",":","acetate","+","diphosphate","=","acetyl","phosphate","+","phosphate","."),4372972). assertion_content_comment('tOboGo_AcetateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acetate",",","the","anion","of","acetic","acid","."),4026492). assertion_content_comment('tOboGo_AcetateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","acetate","from","one","side","of","the","membrane","to","the","other",".","Acetate","is","the","2-carbon","carboxylic","acid","ethanoic","acid","."),4295939). assertion_content_comment('tOboGo_AcetateTransmembraneTransport',s("The","directed","movement","of","acetate","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Acetate","is","the","2-carbon","carboxylic","acid","ethanoic","acid","."),4228585). assertion_content_comment('tOboGo_AcetateTransport',s("The","directed","movement","of","acetate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4228568). assertion_content_comment('tOboGo_AcetoacetateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","acetoacetate","+","H","(","+",")","=","acetone","+","CO","(","2",")"),4373008). assertion_content_comment('tOboGo_AcetoaceticAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","acetoacetic","acid",",","a","beta-keto","acid","of","the","keto","acid","group",",","empirical","formula","is","C4H6O3","or","CH3COCH2COOH","."),4324883). assertion_content_comment('tOboGo_AcetoaceticAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetoacetic","acid",",","a","beta-keto","acid","of","the","keto","acid","group",",","empirical","formula","is","C4H6O3","or","CH3COCH2COOH","."),4324870). assertion_content_comment('tOboGo_AcetoaceticAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acetoacetic","acid",",","3-oxobutanoic","acid",";","the","empirical","formula","is","C4H6O3","or","CH3COCH2COOH","."),4324854). assertion_content_comment('tOboGo_AcetoinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","acetoin",",","3-hydroxy-2-butanone","."),4300360). assertion_content_comment('tOboGo_AcetoinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetoin",",","3-hydroxy-2-butanone","."),4300375). assertion_content_comment('tOboGo_AcetoinDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","acetoin","+","NAD","+","=","diacetyl","+","NADH","+","H","+"),4186706). assertion_content_comment('tOboGo_AcetoinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acetoin",",","3-hydroxy-2-butanone",",","often","as","part","of","a","fermentation","pathway","or","for","use","as","a","carbon","source","."),4300074). assertion_content_comment('tOboGo_AcetoinRacemaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-acetoin","=","(","R",")","-acetoin","."),4372152). assertion_content_comment('tOboGo_AcetolactateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2-hydroxy-2-methyl-3-oxobutanoate","=","(","R",")","-2-acetoin","+","CO2","."),4372140). assertion_content_comment('tOboGo_AcetolactateSynthaseActivity',s("Catalysis","of","the","reaction",":","2","pyruvate","=","2-acetolactate","+","CO2","."),4187234). assertion_content_comment('tOboGo_AcetolactateSynthaseComplex',s("A","dimeric","(","a","large","and","a","small","chain",")","or","tetrameric","(","two","large","and","two","small","chains",")","enzyme","complex",".","Catalyzes","the","formation","of","acetolactate","from","pyruvate","."),4221107). assertion_content_comment('tOboGo_AcetoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","acetone",",","propan-2-one","."),4324809). assertion_content_comment('tOboGo_AcetoneCarboxylaseActivity',s("Catalysis","of","the","reaction",":","acetone","+","ATP","+","CO","(","2",")","+","2","H","(","2",")","O","=","acetoacetate","+","AMP","+","4","H","(","+",")","+","2","phosphate","."),4275273). assertion_content_comment('tOboGo_AcetoneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetone",",","propan-2-one","."),4324829). assertion_content_comment('tOboGo_AcetoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acetone",",","propan-2-one","."),4324800). assertion_content_comment('tOboGo_AcetophenoneCarboxylaseActivity',s("Catalysis","of","the","reaction",":","acetophenone","+","CO2","=","H","+","+","benzoyl","acetate","."),4278394). assertion_content_comment('tOboGo_AcetoxybutynylbithiopheneDeacetylaseActivity',s("Catalysis","of","the","reaction",":","5-","(","4-acetoxybut-1-ynyl",")","-2",",","2","'","-bithiophene","+","H","(","2",")","O","=","5-","(","4-hydroxy-but-1-ynyl",")","-2",",","2","'","-bithiophene","+","acetate","+","H","(","+",")"),4368808). assertion_content_comment('tOboGo_AcetylajmalineEsteraseActivity',s("Catalysis","of","the","reactions",":","17-O-acetylajmaline","+","H2O","=","ajmaline","+","acetate",",","and","17-O-acetylnorajmaline","+","H2O","=","norajmaline","+","acetate","."),4343530). assertion_content_comment('tOboGo_AcetylalkylglycerolAcetylhydrolaseActivity',s("Catalysis","of","the","reaction",":","2-acetyl-1-alkyl-sn-glycerol","+","H","(","2",")","O","=","1-alkyl-sn-glycerol","+","acetate","+","H","(","+",")"),4368685). assertion_content_comment('tOboGo_AcetylcholineBinding',s("Interacting","selectively","and","non-covalently","with","acetylcholine",",","an","acetic","acid","ester","of","the","organic","base","choline","that","functions","as","a","neurotransmitter",",","released","at","the","synapses","of","parasympathetic","nerves","and","at","neuromuscular","junctions","."),4198859). assertion_content_comment('tOboGo_AcetylcholineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","acetylcholine",",","the","acetic","acid","ester","of","the","organic","base","choline","."),4256297). assertion_content_comment('tOboGo_AcetylcholineCatabolicProcessInSynapticCleft',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetylcholine","that","occurs","in","the","synaptic","cleft","during","synaptic","transmission","."),3981752). assertion_content_comment('tOboGo_AcetylcholineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetylcholine",",","the","acetic","acid","ester","of","the","organic","base","choline","."),3981746). assertion_content_comment('tOboGo_Acetylcholine_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","H","+","(","out",")","+","acetylcholine","(","in",")","=","H","+","(","in",")","+","acetylcholine","(","out",")"),4215762). assertion_content_comment('tOboGo_AcetylcholineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acetylcholine",",","the","acetic","acid","ester","of","the","organic","base","choline",".","Acetylcholine","is","a","major","neurotransmitter","and","neuromodulator","both","in","the","central","and","peripheral","nervous","systems",".","It","also","acts","as","a","paracrine","signal","in","various","non-neural","tissues","."),3981700). assertion_content_comment('tOboGo_AcetylcholineReceptorActivatorActivity',s("Interacting","(","directly","or","indirectly",")","with","acetylcholine","receptors","such","that","the","proportion","of","receptors","in","the","active","form","is","increased","."),4310803). assertion_content_comment('tOboGo_AcetylcholineReceptorActivity',s("Combining","with","acetylcholine","to","initiate","a","change","in","cell","activity","."),4198861). assertion_content_comment('tOboGo_AcetylcholineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","acetylcholine","receptor","."),4347985). assertion_content_comment('tOboGo_AcetylcholineReceptorInhibitorActivity',s("Interacting","(","directly","or","indirectly",")","with","acetylcholine","receptors","such","that","the","proportion","of","receptors","in","the","active","form","is","decreased","."),4310793). assertion_content_comment('tOboGo_AcetylcholineReceptorRegulatorActivity',s("Interacting","(","directly","or","indirectly",")","with","acetylcholine","receptors","such","that","the","proportion","of","receptors","in","the","active","form","is","changed","."),4170832). assertion_content_comment('tOboGo_AcetylcholineSecretion',s("The","regulated","release","of","acetylcholine","by","a","cell","or","group","of","cells",".","The","acetylcholine","is","a","neurotransmitter","that","acts","in","both","the","peripheral","nervous","system","(","PNS",")","and","central","nervous","system","(","CNS",")"),4039296). assertion_content_comment('tOboGo_AcetylcholinesteraseActivity',s("Catalysis","of","the","reaction",":","acetylcholine","+","H2O","=","choline","+","acetate","."),4186437). assertion_content_comment('tOboGo_AcetylcholineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","acetylcholine","from","one","side","of","the","membrane","to","the","other",".","Acetylcholine","is","an","acetic","acid","ester","of","the","organic","base","choline","and","functions","as","a","neurotransmitter",",","released","at","the","synapses","of","parasympathetic","nerves","and","at","neuromuscular","junctions","."),4215759). assertion_content_comment('tOboGo_AcetylcholineTransport',s("The","directed","movement","of","acetylcholine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Acetylcholine","is","an","acetic","acid","ester","of","the","organic","base","choline","and","functions","as","a","neurotransmitter",",","released","at","the","synapses","of","parasympathetic","nerves","and","at","neuromuscular","junctions","."),4039294). assertion_content_comment('tOboGo_AcetylcholineUptake',s("The","directed","movement","of","acetylcholine","into","a","cell",",","typically","presynaptic","neurons","or","glial","cells",".","Acetylcholine","is","a","major","neurotransmitter","and","neuromodulator","both","in","the","central","and","peripheral","nervous","systems",".","It","also","acts","as","a","paracrine","signal","in","various","non-neural","tissues","."),4121559). assertion_content_comment('tOboGo_AcetyldiaminopimelateAminotransferaseActivity',s("Catalysis","of","the","reaction",":","N-acetyl-L-2",",","6-diaminoheptanedioate","+","2-oxoglutarate","=","N-acetyl-2-L-amino-6-oxoheptanedioate","+","L-glutamate","."),4326071). assertion_content_comment('tOboGo_AcetylenedicarboxylateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","acetylenedicarboxylate","=","CO2","+","pyruvate","."),4266338). assertion_content_comment('tOboGo_AcetyleneHydrataseActivity',s("Catalysis","of","the","reaction",":","acetaldehyde","=","acetylene","+","H","(","2",")","O","."),4273581). assertion_content_comment('tOboGo_AcetyleneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acetylene",",","formula","CH2CH2",",","the","simplest","of","the","alkynes","."),4241103). assertion_content_comment('tOboGo_AcetylesteraseActivity',s("Catalysis","of","the","reaction",":","an","acetic","ester","+","H2O","=","an","alcohol","+","acetate","."),4246621). assertion_content_comment('tOboGo_AcetylgalactosaminyltransferaseActivity',s("Catalysis","of","the","transfer","of","an","N-acetylgalactosaminyl","residue","from","UDP-N-acetyl-galactosamine","to","an","oligosaccharide","."),4184720). assertion_content_comment('tOboGo_AcetylglucosaminyltransferaseActivity',s("Catalysis","of","the","transfer","of","an","N-acetylglucosaminyl","residue","from","UDP-N-acetyl-glucosamine","to","a","sugar","."),4183475). assertion_content_comment('tOboGo_AcetylglutamateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","N-acetyl-L-glutamate","=","ADP","+","N-acetyl-L-glutamate-5-phosphate","."),4186483). assertion_content_comment('tOboGo_AcetylglutamateKinaseRegulatorActivity',s("Modulates","the","enzyme","activity","of","acetylglutamate","kinase","."),4332466). assertion_content_comment('tOboGo_AcetylindoxylOxidaseActivity',s("Catalysis","of","the","reaction",":","N-acetylindoxyl","+","O2","=","N-acetylisatin","+","unknown","."),4372129). assertion_content_comment('tOboGo_AcetylornithineDeacetylaseActivity',s("Catalysis","of","the","reaction",":","N2-acetyl-L-ornithine","+","H2O","=","acetate","+","L-ornithine","."),4251760). assertion_content_comment('tOboGo_AcetylputrescineDeacetylaseActivity',s("Catalysis","of","the","reaction",":","N-acetylputrescine","+","H","(","2",")","O","=","acetate","+","putrescine","."),4372119). assertion_content_comment('tOboGo_AcetylpyruvateHydrolaseActivity',s("Catalysis","of","the","reaction",":","acetylpyruvate","+","H","(","2",")","O","=","acetate","+","H","(","+",")","+","pyruvate","."),4274361). assertion_content_comment('tOboGo_AcetylsalicylateDeacetylaseActivity',s("Catalysis","of","the","reaction",":","acetylsalicylate","+","H","(","2",")","O","=","acetate","+","H","(","+",")","+","salicylate","."),4372105). assertion_content_comment('tOboGo_AcetylspermidineDeacetylaseActivity',s("Catalysis","of","the","reaction",":","N","(","8",")","-acetylspermidine","+","H","(","2",")","O","=","acetate","+","spermidine","."),4372048). assertion_content_comment('tOboGo_AcetyltransferaseActivatorActivity',s("Increases","the","activity","of","an","aceyltransferase",",","an","enzyme","which","catalyzes","the","transfer","of","an","acetyl","group","to","an","acceptor","molecule","."),4336479). assertion_content_comment('tOboGo_AcetyltransferaseActivity',s("Catalysis","of","the","transfer","of","an","acetyl","group","to","an","acceptor","molecule","."),4187134). assertion_content_comment('tOboGo_AcetylxylanEsteraseActivity',s("Catalysis","of","the","deacetylation","of","xylans","and","xylo-oligosaccharides","."),4359100). assertion_content_comment('tOboGo_ACFComplex',s("A","chromatin-remodeling","complex","that","catalyzes","the","ATP-dependent","assembly","of","periodic","nucleosome","arrays",".","In","Drosophila",",","the","complex","comprises","ACF1","and","ISWI","."),4305515). assertion_content_comment('tOboGo_AchiasmateMeiosisI',s("The","first","division","of","meiosis","in","which","homologous","chromosomes","are","paired","and","segregated","from","each","other",",","occurring","in","the","constitutive","absence","of","chiasmata","."),4363766). assertion_content_comment('tOboGo_AchromobactinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","achromobactin",",","a","citrate","siderophore","."),4315426). assertion_content_comment('tOboGo_AchromobactinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","achromobactin",",","a","citrate","siderophore","."),4315443). assertion_content_comment('tOboGo_AchromobactinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","achromobactin",",","a","citrate","siderophore","."),4315423). assertion_content_comment('tOboGo_AchromobactinTransporterActivity',s("Enables","the","directed","movement","of","achromobactin",",","a","citrate","siderophore",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4315727). assertion_content_comment('tOboGo_AchromobactinTransport',s("The","directed","movement","of","achromobactin",",","a","citrate","siderophore",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4315738). assertion_content_comment('tOboGo_AcidicAminoAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","acidic","amino","acids","from","one","side","of","a","membrane","to","the","other",".","Acidic","amino","acids","have","a","pH","below","7","."),4216031). assertion_content_comment('tOboGo_AcidicAminoAcidTransport',s("The","directed","movement","of","acidic","amino","acids",",","amino","acids","with","a","pH","below","7",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990608). assertion_content_comment('tOboGo_AcidicEpididymalGlycoprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217535). assertion_content_comment('tOboGo_AcidicKeratin',s("OBSOLETE",".","A","type","of","intermediate","filament","."),4301108). assertion_content_comment('tOboGo_AcidocalcisomeLumen',s("The","volume","enclosed","by","the","membranes","of","an","acidocalcisome","."),4077129). assertion_content_comment('tOboGo_AcidocalcisomeMembrane',s("The","lipid","bilayer","surrounding","an","acidocalcisome","."),4065725). assertion_content_comment('tOboGo_Acidocalcisome',s("An","electron-dense","acidic","membrane-bounded","organelle","which","contains","a","matrix","of","pyrophosphate","and","polyphosphates","with","bound","calcium","and","other","cations","."),4065711). assertion_content_comment('tOboGo_AcidPhosphataseActivity',s("Catalysis","of","the","reaction",":","an","orthophosphoric","monoester","+","H2O","=","an","alcohol","+","phosphate",",","with","an","acid","pH","optimum","."),4186224). assertion_content_comment('tOboGo_AcidSecretion',s("The","controlled","release","of","acid","by","a","cell","or","group","of","cells","."),4117676). assertion_content_comment('tOboGo_AcinarCellDifferentiationInvolvedInSalivaryGlandDevelopment',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","structural","and/or","functional","features","that","characterize","an","acinar","cell","of","the","salivary","gland",".","Acinar","cells","are","protein-secreting","cells","in","the","gland","."),4161213). assertion_content_comment('tOboGo_AcireductoneSynthaseActivity',s("Catalysis","of","the","reactions",":","5-","(","methylthio",")","-2",",","3-dioxopentyl","phosphate","+","H2O","=","1",",","2-dihydroxy-5-","(","methylthio",")","pent-1-en-3-one","+","phosphate",";","(","1a",")","5-","(","methylthio",")","-2",",","3-dioxopentyl","phosphate","=","2-hydroxy-5-","(","methylthio",")","-3-oxopent-1-enyl","phosphate",";","(","1b",")","2-hydroxy-5-","(","methylthio",")","-3-oxopent-1-enyl","phosphate","+","H2O","=","1",",","2-dihydroxy-5-","(","methylthio",")","pent-1-en-3-one","+","phosphate","."),4326590). assertion_content_comment('tOboGo_AconitateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","cis-aconitate","+","H","(","+",")","=","CO","(","2",")","+","itaconate","."),4372079). assertion_content_comment('tOboGo_AconitateHydrataseActivity',s("Catalysis","of","the","reactions",":","citrate","=","cis-aconitate","+","H2O",",","and","cis-aconitate","+","H2O","=","isocitrate",".","This","reaction","is","the","interconversion","of","citrate","and","isocitrate","via","the","labile",",","enzyme-bound","intermediate","cis-aconitate",".","Water","is","removed","from","one","part","of","the","citrate","molecule","and","added","back","to","a","different","atom","to","form","isocitrate","."),4186245). assertion_content_comment('tOboGo_AcquisitionBySymbiontOfNutrientsFromHostViaSiderophores',s("The","process","that","begins","with","the","production","and","formation","of","siderophores","in","an","organism","that","are","required","for","the","acquisition","and","utilization","of","nutrients","from","its","host","organism",",","and","the","ends","with","the","acquirement","of","the","nutrients",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194659). assertion_content_comment('tOboGo_AcquisitionOfDesiccationTolerance',s("The","process","in","which","a","seed","acquires","tolerance","to","severe","drying",",","before","entering","into","a","dry",",","either","dormant","or","quiescent","state","."),4107154). assertion_content_comment('tOboGo_AcquisitionOfNutrientsFromHost',s("The","process","that","begins","with","the","production","and","formation","of","structures","and","molecules","in","an","organism","that","are","required","for","the","acquisition","and","utilization","of","nutrients","from","its","host","organism",",","and","the","ends","with","the","acquirement","of","the","nutrients",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080113). assertion_content_comment('tOboGo_AcquisitionOfNutrientsFromOtherOrganismDuringSymbioticInteraction',s("The","production","of","structures","and/or","molecules","in","an","organism","that","are","required","for","the","acquisition","and/or","utilization","of","nutrients","obtained","from","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4080098). assertion_content_comment('tOboGo_AcquisitionOfNutrientsFromSymbiont',s("The","production","of","structures","and/or","molecules","in","an","organism","that","are","required","for","the","acquisition","and/or","utilization","of","nutrients","obtained","from","its","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110421). assertion_content_comment('tOboGo_AcquisitionOfReproductiveCompetence',s("The","process","in","which","a","plant","acquires","the","ability","to","respond","to","a","floral","inductive","signal","."),4329980). assertion_content_comment('tOboGo_Acridine_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","H","+","(","out",")","+","acridine","(","in",")","=","H","+","(","in",")","+","acridine","(","out",")"),4316241). assertion_content_comment('tOboGo_AcridineTransporterActivity',s("Enables","the","directed","movement","of","acridine","(","10-azaanthracene",")",",","a","heterocyclic","ring","compound","found","in","crude","coal-tar","anthracene",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4315831). assertion_content_comment('tOboGo_AcridineTransport',s("The","directed","movement","of","acridine","(","10-azaanthracene",")",",","a","heterocyclic","ring","compound","found","in","crude","coal-tar","anthracene",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4316003). assertion_content_comment('tOboGo_AcridoneSynthaseActivity',s("Catalysis","of","the","reaction",":","N-methylanthranilyl-CoA","+","3","H","(","+",")","+","3","malonyl-CoA","=","1",",","3-dihydroxy-N-methylacridone","+","3","CO","(","2",")","+","4","CoA","+","H","(","2",")","O","."),4277796). assertion_content_comment('tOboGo_AcriflavineTransporterActivity',s("Enables","the","directed","movement","of","acriflavin","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Acriflavin","is","a","fluorescent","dye","used","as","a","local","antiseptic","and","also","as","a","biological","stain",".","It","intercalates","into","nucleic","acids","thereby","inhibiting","bacterial","and","viral","replication","."),4293424). assertion_content_comment('tOboGo_AcriflavineTransport',s("The","directed","movement","of","acriflavine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Acriflavine","is","a","fluorescent","dye","used","as","a","local","antiseptic","and","also","as","a","biological","stain",".","It","intercalates","into","nucleic","acids","thereby","inhibiting","bacterial","and","viral","replication","."),4294166). assertion_content_comment('tOboGo_AcropetalAuxinTransport',s("The","unidirectional","movement","of","auxin","from","the","base","towards","the","apex","of","an","organ",",","including","the","shoot",",","leaf",",","primary","root",",","or","lateral","root","."),4336216). assertion_content_comment('tOboGo_AcrosinActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","of","Arg-Xaa","&","gt",";","Lys-Xaa","."),4209559). assertion_content_comment('tOboGo_AcrosinBinding',s("Interacting","selectively","and","non-covalently","with","acrosin",",","a","protein","that","is","found","in","the","acrosomes","of","sperm","and","possesses","protease","and","carbohydrate","binding","activities","."),4329402). assertion_content_comment('tOboGo_AcrosinHeavyChainBinding',s("Interacting","selectively","and","non-covalently","with","the","larger","of","the","two","covalently","linked","polypeptide","chains","of","acrosin","."),4329404). assertion_content_comment('tOboGo_AcrosinLightChainBinding',s("Interacting","selectively","and","non-covalently","with","the","smaller","of","the","two","covalently","linked","polypeptide","chains","of","acrosin","."),4329441). assertion_content_comment('tOboGo_AcrosomalLumen',s("The","volume","enclosed","within","the","acrosome","membrane","."),4092891). assertion_content_comment('tOboGo_AcrosomalMatrix',s("A","structural","framework",",","or","'","dense","core","'","at","the","interior","of","an","acrosome",".","May","regulate","the","distribution","of","hydrolases","within","the","acrosome","and","their","release","during","the","acrosome","reaction","."),4092870). assertion_content_comment('tOboGo_AcrosomalMembrane',s("The","membrane","that","surrounds","the","acrosomal","lumen",".","The","acrosome","is","a","special","type","of","lysosome","in","the","head","of","a","spermatozoon","that","contains","acid","hydrolases","and","is","concerned","with","the","breakdown","of","the","outer","membrane","of","the","ovum","during","fertilization","."),3989636). assertion_content_comment('tOboGo_AcrosomalVesicleExocytosis',s("The","release","of","intracellular","molecules","contained","within","the","acrosomal","granule","by","fusion","of","the","vesicle","with","the","plasma","membrane","of","the","oocyte",",","requiring","calcium","ions","."),4117544). assertion_content_comment('tOboGo_AcrosomalVesicle',s("A","structure","in","the","head","of","a","spermatozoon","that","contains","acid","hydrolases",",","and","is","concerned","with","the","breakdown","of","the","outer","membrane","of","the","ovum","during","fertilization",".","It","lies","just","beneath","the","plasma","membrane","and","is","derived","from","the","lysosome","."),3989633). assertion_content_comment('tOboGo_AcrosomeAssembly',s("The","formation","of","the","acrosome","from","the","spermatid","Golgi","."),3982273). assertion_content_comment('tOboGo_AcrosomeMatrixDispersal',s("The","proteolytic","digestion","of","components","in","the","acrosomal","matrix","that","allows","for","their","release","into","the","egg",".","The","dispersal","of","the","components","allows","for","the","inner","acrosomal","membrane","to","interact","with","the","egg","."),3990257). assertion_content_comment('tOboGo_AcrosomeReaction',s("The","discharge",",","by","sperm",",","of","a","single",",","anterior","secretory","granule","following","the","sperm","'","s","attachment","to","the","zona","pellucida","surrounding","the","oocyte",".","The","process","begins","with","the","fusion","of","the","outer","acrosomal","membrane","with","the","sperm","plasma","membrane","and","ends","with","the","exocytosis","of","the","acrosomal","contents","into","the","egg","."),3990182). assertion_content_comment('tOboGo_AcrylonitrileCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acrylonitrile",",","a","colorless",",","volatile","liquid","with","a","pungent","odor",".","Acrylonitrile","is","used","in","the","production","of","acrylic","fibers",",","plastics",",","and","synthetic","rubbers","."),4238066). assertion_content_comment('tOboGo_AcrylonitrileMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acrylonitrile",",","a","colorless",",","volatile","liquid","with","a","pungent","odor",".","Acrylonitrile","is","used","in","the","production","of","acrylic","fibers",",","plastics",",","and","synthetic","rubbers","."),4238047). assertion_content_comment('tOboGo_ActinBinding',s("Interacting","selectively","and","non-covalently","with","monomeric","or","multimeric","forms","of","actin",",","including","actin","filaments","."),4192965). assertion_content_comment('tOboGo_ActinBundlingActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193169). assertion_content_comment('tOboGo_ActinCappingProteinOfDynactinComplex',s("A","heterodimer","consisting","of","alpha","and","beta","subunits","that","binds","to","and","caps","the","barbed","ends","of","actin","filaments",",","nucleates","the","polymerization","of","actin","monomers","but","does","not","sever","actin","filaments",",","and","which","is","a","part","of","the","dynactin","complex","."),4008396). assertion_content_comment('tOboGo_ActinCap',s("Polarized","accumulation","of","cytoskeletal","proteins","(","including","F-actin",")","and","regulatory","proteins","in","a","cell",".","An","example","of","this","is","the","actin","cap","found","in","Saccharomyces","cerevisiae","."),4047007). assertion_content_comment('tOboGo_ActinCorticalPatchAssembly',s("Assembly","of","an","actin","cortical","patch",",","a","discrete","actin-containing","structure","found","at","the","plasma","membrane","of","fungal","cells","."),4346095). assertion_content_comment('tOboGo_ActinCorticalPatchDistribution',s("OBSOLETE",".","Any","process","that","establishes","the","spatial","arrangement","of","actin","cortical","patches",".","An","actin","cortical","patch","is","a","discrete","actin-containing","structure","found","at","the","plasma","membrane","in","fungal","cells","."),4384845). assertion_content_comment('tOboGo_ActinCorticalPatchLocalization',s("Any","process","in","which","actin","cortical","patches","are","transported","to",",","or","maintained","in",",","a","specific","location",".","An","actin","cortical","patch","is","a","discrete","actin-containing","structure","found","just","beneath","the","plasma","membrane","in","fungal","cells","."),4116897). assertion_content_comment('tOboGo_ActinCorticalPatch',s("A","discrete","actin-containing","structure","found","at","the","plasma","membrane","in","cells",",","at","sites","of","endocytosis",";","formed","of","networks","of","branched","actin","filaments","that","lie","just","beneath","the","plasma","membrane","and","assemble",",","move",",","and","disassemble","rapidly",".","An","example","of","this","is","the","actin","cortical","patch","found","in","Saccharomyces","cerevisiae","."),4047057). assertion_content_comment('tOboGo_ActinCrosslinkFormation',s("The","process","in","which","two","or","more","actin","filaments","are","connected","together","by","proteins","that","act","as","crosslinks","between","the","filaments",".","The","crosslinked","filaments","may","be","on","the","same","or","differing","axes","."),4280152). assertion_content_comment('tOboGo_ActinCytoskeletonOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","actin","filaments","and","their","associated","proteins","."),3978669). assertion_content_comment('tOboGo_ActinCytoskeletonReorganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","dynamic","structural","changes","to","the","arrangement","of","constituent","parts","of","cytoskeletal","structures","comprising","actin","filaments","and","their","associated","proteins","."),4140399). assertion_content_comment('tOboGo_ActinCytoskeleton',s("The","part","of","the","cytoskeleton","(","the","internal","framework","of","a","cell",")","composed","of","actin","and","associated","proteins",".","Includes","actin","cytoskeleton-associated","complexes","."),3971836). assertion_content_comment('tOboGo_ActinDepolymerizingActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193258). assertion_content_comment('tOboGo_ActinFilamentBinding',s("Interacting","selectively","and","non-covalently","with","an","actin","filament",",","also","known","as","F-actin",",","a","helical","filamentous","polymer","of","globular","G-actin","subunits","."),4193153). assertion_content_comment('tOboGo_ActinFilamentBranching',s("The","formation","of","daughter","actin","filament","branches","at","an","angle","on","the","sides","of","preexisting","mother","filaments","."),4154831). assertion_content_comment('tOboGo_ActinFilamentBundleAssemblyInvolvedInActomyosinContractileRingFormation',s("A","process","of","actin","filament","bundle","formation","that","occurs","in","the","context","of","assembling","an","actomyosin","contractile","ring","during","cytokinesis","."),4129581). assertion_content_comment('tOboGo_ActinFilamentBundleAssembly',s("The","assembly","of","actin","filament","bundles",";","actin","filaments","are","on","the","same","axis","but","may","be","oriented","with","the","same","or","opposite","polarities","and","may","be","packed","with","different","levels","of","tightness","."),4052747). assertion_content_comment('tOboGo_ActinFilamentBundleConvergenceInvolvedInActomyosinContractileRingFormation',s("A","process","of","actin","filament","bundle","distribution","that","occurs","in","the","context","of","assembling","an","actomyosin","contractile","ring","during","cytokinesis",",","and","that","results","in","the","compaction","of","actin","filaments","into","a","tight","ring","."),4129571). assertion_content_comment('tOboGo_ActinFilamentBundleDistribution',s("Any","cellular","process","that","establishes","the","spatial","arrangement","of","actin","filament","bundles","within","the","cell","."),4129568). assertion_content_comment('tOboGo_ActinFilamentBundle',s("An","assembly","of","actin","filaments","that","are","on","the","same","axis","but","may","be","oriented","with","the","same","or","opposite","polarities","and","may","be","packed","with","different","levels","of","tightness","."),4055624). assertion_content_comment('tOboGo_ActinFilamentCapping',s("The","binding","of","a","protein","or","protein","complex","to","the","end","of","an","actin","filament",",","thus","preventing","the","addition",",","exchange","or","removal","of","further","actin","subunits","."),4193194). assertion_content_comment('tOboGo_ActinFilamentDebranching',s("An","actin","filament","severing","process","that","results","in","the","removal","of","actin","filament","branches","specifically","at","the","branch","points","."),4171004). assertion_content_comment('tOboGo_ActinFilamentDepolymerization',s("Disassembly","of","actin","filaments","by","the","removal","of","actin","monomers","from","a","filament","."),4050846). assertion_content_comment('tOboGo_ActinFilamentFragmentation',s("The","severing","of","actin","filaments","into","numerous","short","fragments",",","usually","mediated","by","actin","severing","proteins","."),4306899). assertion_content_comment('tOboGo_ActinFilamentNetworkFormation',s("The","assembly","of","a","network","of","actin","filaments",";","actin","filaments","on","different","axes","and","with","differing","orientations","are","crosslinked","together","to","form","a","mesh","of","filaments","."),4285224). assertion_content_comment('tOboGo_ActinFilamentOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","actin","filaments",".","Includes","processes","that","control","the","spatial","distribution","of","actin","filaments",",","such","as","organizing","filaments","into","meshworks",",","bundles",",","or","other","structures",",","as","by","cross-linking","."),4014698). assertion_content_comment('tOboGo_ActinFilamentPolymerization',s("Assembly","of","actin","filaments","by","the","addition","of","actin","monomers","to","a","filament","."),4050799). assertion_content_comment('tOboGo_ActinFilamentReorganizationInvolvedInCellCycle',s("The","cell","cycle","process","in","which","rearrangement","of","the","spatial","distribution","of","actin","filaments","and","associated","proteins","occurs","."),4306868). assertion_content_comment('tOboGo_ActinFilament',s("A","filamentous","structure","formed","of","a","two-stranded","helical","polymer","of","the","protein","actin","and","associated","proteins",".","Actin","filaments","are","a","major","component","of","the","contractile","apparatus","of","skeletal","muscle","and","the","microfilaments","of","the","cytoskeleton","of","eukaryotic","cells",".","The","filaments",",","comprising","polymerized","globular","actin","molecules",",","appear","as","flexible","structures","with","a","diameter","of","5-9","nm",".","They","are","organized","into","a","variety","of","linear","bundles",",","two-dimensional","networks",",","and","three","dimensional","gels",".","In","the","cytoskeleton","they","are","most","highly","concentrated","in","the","cortex","of","the","cell","just","beneath","the","plasma","membrane","."),4008407). assertion_content_comment('tOboGo_ActinFilamentSeveringActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193298). assertion_content_comment('tOboGo_ActinFilamentSevering',s("The","process","in","which","an","actin","filament","is","broken","down","into","smaller","filaments","."),4170999). assertion_content_comment('tOboGo_ActinFilamentUncapping',s("The","removal","of","capping","protein","from","the","end","of","actin","filaments","to","free","the","ends","for","addition",",","exchange","or","removal","of","further","actin","subunits","."),4285205). assertion_content_comment('tOboGo_ActinHomodimerizationActivity',s("Interacting","selectively","and","non-covalently","with","an","identical","actin","monomer","to","form","a","homodimer","."),4338520). assertion_content_comment('tOboGo_ActinidainActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","proteins","with","broad","specificity","for","peptide","bonds",",","with","preference","for","a","residue","bearing","a","large","hydrophobic","side","chain","at","the","P2","position",".","Does","not","accept","Val","at","P1","'"),4246758). assertion_content_comment('tOboGo_ActininBinding',s("Interacting","selectively","and","non-covalently","with","actinin",",","any","member","of","a","family","of","proteins","that","crosslink","F-actin","."),4286072). assertion_content_comment('tOboGo_ActinLateralBinding',s("Interacting","selectively","and","non-covalently","with","an","actin","filament","along","its","length","."),4193247). assertion_content_comment('tOboGo_ActinModification',s("Covalent","modification","of","an","actin","molecule","."),4094357). assertion_content_comment('tOboGo_ActinModulatingActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4192948). assertion_content_comment('tOboGo_ActinMonomerBinding',s("Interacting","selectively","and","non-covalently","with","monomeric","actin",",","also","known","as","G-actin","."),4193237). assertion_content_comment('tOboGo_ActinMonomerSequesteringActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193287). assertion_content_comment('tOboGo_ActinNucleation',s("The","initial","step","in","the","formation","of","an","actin","filament",",","in","which","actin","monomers","combine","to","form","a","new","filament",".","Nucleation","is","slow","relative","to","the","subsequent","addition","of","more","monomers","to","extend","the","filament","."),4075084). assertion_content_comment('tOboGo_ActinomycinLactonaseActivity',s("Catalysis","of","the","reaction",":","actinomycin","+","H2O","=","actinomycinic","monolactone","."),4372036). assertion_content_comment('tOboGo_ActinPhosphorylation',s("The","transfer","of","one","or","more","phosphate","groups","to","an","actin","molecule","."),4094359). assertion_content_comment('tOboGo_ActinPolymerizationOrDepolymerization',s("Assembly","or","disassembly","of","actin","filaments","by","the","addition","or","removal","of","actin","monomers","from","a","filament","."),4014703). assertion_content_comment('tOboGo_ActinPolymerizingActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4253205). assertion_content_comment('tOboGo_ActinRodAssembly',s("The","assembly","of","actin","rods",",","a","cellular","structure","consisting","of","parallel",",","hexagonally","arranged","actin","tubules","."),4320025). assertion_content_comment('tOboGo_ActinRod',s("A","cellular","structure","consisting","of","parallel",",","hexagonally","arranged","actin","tubules",",","comprising","filamentous","actin","and","associated","proteins",".","Found","in","the","germinating","spores","of","Dictyostelium","discoideum","."),4061152). assertion_content_comment('tOboGo_ActinTubule',s("A","cellular","structure",",","approximately","13","nm","in","diameter",",","consisting","of","three","actin","filaments","bundled","together","."),4061162). assertion_content_comment('tOboGo_ActinUbiquitination',s("The","modification","of","actin","by","addition","of","ubiquitin","groups","."),4235379). assertion_content_comment('tOboGo_ActivatedTCellAutonomousCellDeath',s("A","type","of","T","cell","apoptosis","that","occurs","towards","the","end","of","the","expansion","phase","following","the","initial","activation","of","mature","T","cells","by","antigen","via","the","accumulation","of","pro-apoptotic","gene","products","and","decrease","in","anti-apoptotic","gene","products","."),4137449). assertion_content_comment('tOboGo_ActivatedTCellProliferation',s("The","expansion","of","a","T","cell","population","following","activation","by","an","antigenic","stimulus","."),4080928). assertion_content_comment('tOboGo_ActivatingMHCClassIReceptorActivity',s("Combining","with","a","MHC","class","I","protein","complex","to","mediate","signaling","that","activates","a","lymphocyte","."),4310994). assertion_content_comment('tOboGo_ActivatingTranscriptionFactorBinding',s("Interacting","selectively","and","non-covalently","with","an","activating","transcription","factor",",","any","protein","whose","activity","is","required","to","initiate","or","upregulate","transcription","."),4341593). assertion_content_comment('tOboGo_ActivationOfAdenylateCyclaseActivityByAdrenergicReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","adrenergic","receptor","binding","to","its","physiological","ligand",",","followed","by","activation","of","adenylyl","cyclase","and","a","subsequent","increase","in","the","concentration","of","cyclic","AMP","."),4170475). assertion_content_comment('tOboGo_ActivationOfAdenylateCyclaseActivityByDopamineReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","dopamine","receptor","binding","to","its","physiological","ligand",",","followed","by","activation","of","adenylyl","cyclase","and","a","subsequent","increase","in","the","concentration","of","cyclic","AMP","."),4235943). assertion_content_comment('tOboGo_ActivationOfAdenylateCyclaseActivityBySerotoninReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","serotonin","receptor","binding","to","its","physiological","ligand",",","followed","by","activation","of","adenylyl","cyclase","and","a","subsequent","increase","in","the","concentration","of","cyclic","AMP","."),4235930). assertion_content_comment('tOboGo_ActivationOfAdenylateCyclaseActivity',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","adenylate","cyclase","."),4170446). assertion_content_comment('tOboGo_ActivationOfARFGTPaseActivity',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","ARF","GTPase","through","the","replacement","of","GDP","by","GTP","."),4337449). assertion_content_comment('tOboGo_ActivationOfBipolarCellGrowth',s("Any","process","that","initiates","the","inactive","process","of","bipolar","cell","growth",",","polarized","growth","from","both","ends","of","a","cell","."),4283411). assertion_content_comment('tOboGo_ActivationOfBloodCoagulationViaClottingCascade',s("Any","process","that","initiates","the","clotting","cascade","of","blood","coagulation",",","a","cascade","of","plasma","enzymes","that","is","triggered","following","damage","to","blood","vessels",",","leading","to","formation","of","a","clot","."),3996592). assertion_content_comment('tOboGo_ActivationOfCaspaseActivityByCytochromeC',s("Upregulation","of","the","activity","of","a","caspase",",","any","of","a","group","of","cysteine","proteases","involved","in","apoptosis",",","mediated","by","cytochrome","c","."),4253349). assertion_content_comment('tOboGo_ActivationOfCaspaseActivityByProteinPhosphorylation',s("Upregulation","of","the","activity","of","a","caspase",",","any","of","a","group","of","cysteine","proteases","involved","in","apoptosis",",","by","the","addition","of","a","phosphate","group","."),4253389). assertion_content_comment('tOboGo_ActivationOfCaspaseActivity',s("Upregulation","of","the","activity","of","a","caspase",",","any","of","a","group","of","cysteine","proteases","involved","in","apoptosis","."),4011572). assertion_content_comment('tOboGo_ActivationOfCdc42GTPaseActivity',s("Any","process","that","initiates","the","activity","of","the","inactive","GTPase","Cdc42","through","the","replacement","of","GDP","by","GTP","."),4337327). assertion_content_comment('tOboGo_ActivationOfDopamineReceptorSignalingPathway',s("Any","process","that","initiates","the","dopamine","receptor","protein","signaling","pathway","through","stimulation","of","the","dopamine","receptor","."),4346825). assertion_content_comment('tOboGo_ActivationOfHog1',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235534). assertion_content_comment('tOboGo_ActivationOfImmuneResponse',s("Any","process","that","initiates","an","immune","response","."),3986081). assertion_content_comment('tOboGo_ActivationOfInnateImmuneResponse',s("Any","process","that","initiates","an","innate","immune","response",".","Innate","immune","responses","are","defense","responses","mediated","by","germline","encoded","components","that","directly","recognize","components","of","potential","pathogens",".","Examples","of","this","process","include","activation","of","the","hypersensitive","response","of","Arabidopsis","thaliana","and","activation","of","any","NOD","or","TLR","signaling","pathway","in","vertebrate","species","."),4021882). assertion_content_comment('tOboGo_ActivationOfJAK1KinaseActivity',s("The","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK1","(","Janus","Activated","Kinase","1",")","protein",",","thereby","activating","it","."),4027098). assertion_content_comment('tOboGo_ActivationOfJAK2KinaseActivity',s("The","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK2","(","Janus","Activated","Kinase","2",")","protein",",","thereby","activating","it","."),4027288). assertion_content_comment('tOboGo_ActivationOfJanusKinaseActivity',s("The","process","of","introducing","a","phosphate","group","to","a","tyrosine","residue","of","a","JAK","(","Janus","Activated","Kinase",")","protein",",","thereby","activating","it","."),4027092). assertion_content_comment('tOboGo_ActivationOfJNKKActivity',s("The","initiation","of","the","activity","of","the","inactive","enzyme","JUN","kinase","kinase","(","JNKK",")","activity","in","response","to","phosphorylation","by","a","member","of","the","JUN","kinase","kinase","kinase","(","JNKKK",")","family",",","or","another","upstream","kinase",".","JNKKs","are","involved","in","a","signaling","pathway","that","is","primarily","activated","by","cytokines","and","exposure","to","environmental","stress","."),4016542). assertion_content_comment('tOboGo_ActivationOfJNKKKActivity',s("The","initiation","of","the","activity","of","the","inactive","enzyme","JUN","kinase","kinase","kinase","activity","in","response","to","phosphorylation","by","a","member","of","the","MAP","kinase","kinase","kinase","kinase","(","MAPKKKK",")","family","or","another","upstream","kinase","."),4077805). assertion_content_comment('tOboGo_ActivationOfJUNKinaseActivity',s("The","initiation","of","the","activity","of","the","inactive","enzyme","JUN","kinase","by","phosphorylation","by","a","JUN","kinase","kinase","(","JNKK",")"),4016630). assertion_content_comment('tOboGo_ActivationOfMAPKActivityByAdrenergicReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","adrenergic","receptor","binding","to","its","physiological","ligand",",","followed","by","the","activation","of","a","MAP","kinase","."),4170794). assertion_content_comment('tOboGo_ActivationOfMAPKActivityInvolvedInCellWallBiogenesis',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","in","the","context","of","cell","wall","biogenesis",",","the","assembly","and","arrangement","of","the","cell","wall",",","the","rigid","or","semi-rigid","envelope","lying","outside","the","cell","membrane","of","plant",",","fungal","and","most","prokaryotic","cells","."),3973048). assertion_content_comment('tOboGo_ActivationOfMAPKActivityInvolvedInConjugationWithCellularFusion',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","in","the","context","of","conjugation","with","cellular","fusion","."),4129634). assertion_content_comment('tOboGo_ActivationOfMAPKActivityInvolvedInInnateImmuneResponse',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","in","the","context","of","an","innate","immune","response",",","a","defense","response","mediated","by","germline","encoded","components","that","directly","recognize","components","of","potential","pathogens","."),4082978). assertion_content_comment('tOboGo_ActivationOfMAPKActivityInvolvedInOsmosensorySignalingPathway',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","activity","during","osmolarity","sensing","."),3972617). assertion_content_comment('tOboGo_ActivationOfMAPKActivity',s("The","initiation","of","the","activity","of","the","inactive","enzyme","MAP","kinase","by","phosphorylation","by","a","MAPKK","."),3972611). assertion_content_comment('tOboGo_ActivationOfMAPKDuringSporulationSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310062). assertion_content_comment('tOboGo_ActivationOfMAPKDuringSporulationSensuSaccharomyces',s("OBSOLETE",".","Upregulation","of","MAP","kinase","activity","in","the","context","of","sporulation",".","As","in",",","but","not","restricted","to",",","the","taxon","Saccharomyces","(","Saccharomyces",",","ncbi_taxonomy_id",":","4930",")"),4346444). assertion_content_comment('tOboGo_ActivationOfMAPKKActivityInvolvedInCellWallBiogenesis',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","in","the","context","of","cell","wall","biogenesis",",","the","assembly","and","arrangement","of","the","cell","wall",",","the","rigid","or","semi-rigid","envelope","lying","outside","the","cell","membrane","of","plant",",","fungal","and","most","prokaryotic","cells","."),3973034). assertion_content_comment('tOboGo_ActivationOfMAPKKActivityInvolvedInConjugationWithCellularFusion',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","in","the","context","of","conjugation","with","cellular","fusion","."),4129647). assertion_content_comment('tOboGo_ActivationOfMAPKKActivityInvolvedInInnateImmuneResponse',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","in","the","context","of","an","innate","immune","response",",","a","defense","response","mediated","by","germline","encoded","components","that","directly","recognize","components","of","potential","pathogens","."),4083000). assertion_content_comment('tOboGo_ActivationOfMAPKKActivityInvolvedInOsmosensorySignalingPathway',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","during","osmolarity","sensing","."),3972657). assertion_content_comment('tOboGo_ActivationOfMAPKKActivity',s("The","initiation","of","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","by","phosphorylation","by","a","MAPKKK","."),3972650). assertion_content_comment('tOboGo_ActivationOfMAPKKDuringSporulationSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310012). assertion_content_comment('tOboGo_ActivationOfMAPKKDuringSporulationSensuSaccharomyces',s("OBSOLETE",".","Upregulation","of","a","MAP","kinase","kinase","in","the","context","of","sporulation",".","As","in",",","but","not","restricted","to",",","the","taxon","Saccharomyces","(","Saccharomyces",",","ncbi_taxonomy_id",":","4930",")"),4346547). assertion_content_comment('tOboGo_ActivationOfMAPKKKActivityInvolvedInCellWallBiogenesis',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","kinase","in","the","context","of","cell","wall","biogenesis",",","the","assembly","and","arrangement","of","the","cell","wall",",","the","rigid","or","semi-rigid","envelope","lying","outside","the","cell","membrane","of","plant",",","fungal","and","most","prokaryotic","cells","."),3973020). assertion_content_comment('tOboGo_ActivationOfMAPKKKActivityInvolvedInConjugationWithCellularFusion',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","kinase","in","the","context","of","conjugation","with","cellular","fusion","."),4129661). assertion_content_comment('tOboGo_ActivationOfMAPKKKActivityInvolvedInInnateImmuneResponse',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","kinase","in","the","context","of","an","innate","immune","response",",","a","defense","response","mediated","by","germline","encoded","components","that","directly","recognize","components","of","potential","pathogens","."),4082989). assertion_content_comment('tOboGo_ActivationOfMAPKKKActivityInvolvedInOsmosensorySignalingPathway',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","kinase","during","osmolarity","sensing","."),3972687). assertion_content_comment('tOboGo_ActivationOfMAPKKKActivity',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","MAP","kinase","kinase","kinase","."),3972680). assertion_content_comment('tOboGo_ActivationOfMAPKKKDuringSporulationSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310022). assertion_content_comment('tOboGo_ActivationOfMAPKKKDuringSporulationSensuSaccharomyces',s("OBSOLETE",".","Upregulation","of","MAPKKK","activity","in","the","context","of","sporulation",".","As","in",",","but","not","restricted","to",",","the","taxon","Saccharomyces","(","Saccharomyces",",","ncbi_taxonomy_id",":","4930",")"),4346557). assertion_content_comment('tOboGo_ActivationOfMAPKKKMatingSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310395). assertion_content_comment('tOboGo_ActivationOfMAPKKKMatingSensuSaccharomyces',s("OBSOLETE",".","Upregulation","of","MAPKKK","activity","in","the","context","of","transduction","of","mating","pheromone","signal",",","as","described","for","Saccharomyces","."),4235578). assertion_content_comment('tOboGo_ActivationOfMAPKKKPseudohyphalGrowth',s("OBSOLETE",".","Upregulation","of","MAPKKK","activity","in","the","context","of","regulating","pseudohyphal","or","invasive","growth","."),4345966). assertion_content_comment('tOboGo_ActivationOfMAPKKMatingSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310384). assertion_content_comment('tOboGo_ActivationOfMAPKKMatingSensuSaccharomyces',s("OBSOLETE",".","Upregulation","of","a","MAP","kinase","kinase","in","the","context","of","transduction","of","mating","pheromone","signal",",","as","described","for","Saccharomyces","."),4235545). assertion_content_comment('tOboGo_ActivationOfMAPKKPseudohyphalGrowth',s("OBSOLETE",".","Upregulation","of","a","MAP","kinase","kinase","in","the","context","of","regulating","pseudohyphal","or","invasive","growth","."),4345976). assertion_content_comment('tOboGo_ActivationOfMAPKMatingSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310417). assertion_content_comment('tOboGo_ActivationOfMAPKMatingSensuSaccharomyces',s("OBSOLETE",".","Upregulation","of","MAP","kinase","activity","in","the","context","of","transduction","of","mating","pheromone","signal",",","as","described","for","Saccharomyces","."),4235556). assertion_content_comment('tOboGo_ActivationOfMAPKPseudohyphalGrowth',s("OBSOLETE",".","Upregulation","of","MAP","kinase","activity","in","the","context","of","regulating","pseudohyphal","or","invasive","growth","."),4345946). assertion_content_comment('tOboGo_ActivationOfMeiosisInvolvedInEggActivation',s("Any","process","that","starts","the","inactive","process","of","meiosis","in","an","egg","after","the","egg","has","been","fertilized","or","physiologically","activated",".","Eggs","generally","arrest","in","meiosis","and","complete","the","process","after","activation","."),4117807). assertion_content_comment('tOboGo_ActivationOfMembraneAttackComplex',s("The","activation","of","the","membrane","attack","complex","components","of","the","complement","cascade","which","can","result","in","death","of","a","target","cell","through","cytolysis","."),3987597). assertion_content_comment('tOboGo_ActivationOfMicrotubuleNucleation',s("Any","process","that","starts","the","inactive","process","of","microtubule","nucleation",".","Microtubule","nucleation","is","the","'","de","novo","'","formation","of","a","microtubule",",","in","which","tubulin","heterodimers","form","metastable","oligomeric","aggregates",",","some","of","which","go","on","to","support","formation","of","a","complete","microtubule",".","Microtubule","nucleation","usually","occurs","from","a","specific","site","within","a","cell","."),4155037). assertion_content_comment('tOboGo_ActivationOfMitoticCellCycleSpindleAssemblyCheckpoint',s("Any","process","that","starts","the","inactive","process","of","a","mitotic","cell","cycle","spindle","assembly","checkpoint","."),4155417). assertion_content_comment('tOboGo_ActivationOfMonopolarCellGrowth',s("Any","process","that","initiates","the","inactive","process","of","monopolar","cell","growth",",","polarized","growth","from","one","end","of","a","cell","."),4283508). assertion_content_comment('tOboGo_ActivationOfPbs2',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235524). assertion_content_comment('tOboGo_ActivationOfPhospholipaseA2Activity',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","phospholipase","A2","."),4318024). assertion_content_comment('tOboGo_ActivationOfPhospholipaseCActivityByAdrenergicReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","adrenergic","receptor","binding","to","its","physiological","ligand",",","followed","by","the","activation","of","phospholipase","C","and","the","subsequent","release","of","inositol","trisphosphate","."),4170781). assertion_content_comment('tOboGo_ActivationOfPhospholipaseCActivityByDopamineReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","dopamine","receptor","binding","to","its","physiological","ligand",",","followed","by","the","activation","of","phospholipase","C","and","the","subsequent","release","of","inositol","trisphosphate","."),4108362). assertion_content_comment('tOboGo_ActivationOfPhospholipaseCActivityByMetabotropicGlutamateReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","metabotropic","glutamate","receptor","binding","to","its","physiological","ligand",",","followed","by","the","activation","of","phospholipase","C","and","the","subsequent","release","of","inositol","trisphosphate","."),4236276). assertion_content_comment('tOboGo_ActivationOfPhospholipaseCActivityByMuscarinicAcetylcholineReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","muscarinic","acetylcholine","receptor","binding","to","its","physiological","ligand",",","followed","by","the","activation","of","phospholipase","C","and","the","subsequent","release","of","inositol","trisphosphate","."),4236264). assertion_content_comment('tOboGo_ActivationOfPhospholipaseCActivityBySerotoninReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","serotonin","receptor","binding","to","its","physiological","ligand",",","followed","by","the","activation","of","phospholipase","C","and","the","subsequent","release","of","inositol","trisphosphate","."),4236300). assertion_content_comment('tOboGo_ActivationOfPhospholipaseCActivityByTachykininReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","tachykinin","receptor","binding","to","its","physiological","ligand",",","followed","by","the","activation","of","phospholipase","C","and","the","subsequent","release","of","inositol","trisphosphate","."),4236288). assertion_content_comment('tOboGo_ActivationOfPhospholipaseCActivity',s("The","initiation","of","the","activity","of","the","inactive","enzyme","phospolipase","C","as","the","result","of","a","series","of","molecular","signals","generated","as","a","consequence","of","a","G-protein","coupled","receptor","binding","to","its","physiological","ligand","."),4049044). assertion_content_comment('tOboGo_ActivationOfPhospholipaseDActivity',s("Any","process","that","initiates","the","activity","of","inactive","phospholipase","D","."),4322001). assertion_content_comment('tOboGo_ActivationOfPlasmaProteinsInvolvedInAcuteInflammatoryResponse',s("Any","process","activating","plasma","proteins","by","proteolysis","as","part","of","an","acute","inflammatory","response","."),3995941). assertion_content_comment('tOboGo_ActivationOfProstateInductionByAndrogenReceptorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","an","androgen","binding","to","its","receptor","in","the","urogenital","sinus","mesenchyme","that","initiates","prostate","induction",".","Prostate","induction","is","the","close","range","interaction","of","the","urogenital","sinus","mesenchyme","and","the","urogenital","sinus","epithelium","that","causes","the","cells","of","the","urogenital","sinus","epithelium","to","change","their","fates","and","specify","the","development","of","the","prostate","gland","."),4116800). assertion_content_comment('tOboGo_ActivationOfProteinHistidineKinaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","protein","histidine","kinase","."),4328993). assertion_content_comment('tOboGo_ActivationOfProteinKinaseAActivity',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","protein","kinase","A","."),4359369). assertion_content_comment('tOboGo_ActivationOfProteinKinaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","protein","kinase","."),3972646). assertion_content_comment('tOboGo_ActivationOfProteinKinaseBActivity',s("Any","process","that","initiates","the","activity","of","the","inactive","enzyme","protein","kinase","B","."),4329147). assertion_content_comment('tOboGo_ActivationOfRabGTPaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","GTPase","of","the","Rab","family","through","the","replacement","of","GDP","by","GTP","."),4337461). assertion_content_comment('tOboGo_ActivationOfRacGTPaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","GTPase","of","the","Rac","family","through","the","replacement","of","GDP","by","GTP","."),4337373). assertion_content_comment('tOboGo_ActivationOfRalGTPaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","GTPase","of","the","Ral","family","through","the","replacement","of","GDP","by","GTP","."),4337437). assertion_content_comment('tOboGo_ActivationOfRanGTPaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","GTPase","of","the","Ran","family","through","the","replacement","of","GDP","by","GTP","."),4337425). assertion_content_comment('tOboGo_ActivationOfRapGTPaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","GTPase","of","the","Rap","family","through","the","replacement","of","GDP","by","GTP","."),4337399). assertion_content_comment('tOboGo_ActivationOfRasGTPaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","GTPase","of","the","Ras","superfamily","through","the","replacement","of","GDP","by","GTP","."),4337320). assertion_content_comment('tOboGo_ActivationOfReciprocalMeioticRecombination',s("Any","process","that","starts","the","inactive","process","of","reciprocal","meiotic","recombination",".","Reciprocal","meiotic","recombination","is","the","cell","cycle","process","in","which","double","strand","breaks","are","formed","and","repaired","through","a","double","Holliday","junction","intermediate","."),4335890). assertion_content_comment('tOboGo_ActivationOfRecombinationHML',s("The","activation","of","recombination","at","a","mating","type","locus",",","such","that","it","is","used","in","preference","to","the","other","donor","locus","for","mating","type","switching",";","exemplified","by","the","HML","locus","and","surrounding","sequences","on","Chromosome","III","in","Saccharomyces","cerevisiae","."),4234436). assertion_content_comment('tOboGo_ActivationOfRhoGTPaseActivity',s("Any","process","that","initiates","the","activity","of","an","inactive","GTPase","of","the","Rho","family","through","the","replacement","of","GDP","by","GTP","."),4337323). assertion_content_comment('tOboGo_ActivationOfSignalingProteinActivityInvolvedInUnfoldedProteinResponse',s("The","conversion","of","a","specific","protein",",","possessing","protein","kinase","and","endoribonuclease","activities",",","to","an","active","form","as","a","result","of","signaling","via","the","unfolded","protein","response","."),4013567). assertion_content_comment('tOboGo_ActivationOfSoxRProtein',s("The","conversion","of","the","SoxR","transcription","factor","to","its","active","(","oxidized",")","form","."),4232445). assertion_content_comment('tOboGo_ActivationOfSsk1Protein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235482). assertion_content_comment('tOboGo_ActivationOfSsk2Ssk22Proteins',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235514). assertion_content_comment('tOboGo_ActivationOfTheInhibitorOfKappaKinase',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235727). assertion_content_comment('tOboGo_ActivationOfTransmembraneReceptorProteinTyrosineKinaseActivity',s("Any","process","that","initiates","the","activity","of","the","inactive","transmembrane","receptor","protein","tyrosine","kinase","activity","."),4017123). assertion_content_comment('tOboGo_ActivationOfYpd1Protein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235472). assertion_content_comment('tOboGo_ActivatorEcdysoneReceptorComplex',s("A","protein","complex","consisting","of","a","heterodimer","of","Ecdysone","receptor","(","EcR",")","and","ultraspiracle","(","usp",")","bound","to","the","ligand","ecdysone",",","which","activates","transcription","of","target","genes","."),4255894). assertion_content_comment('tOboGo_ActivatorOfTheEstablishmentOfCompetenceForTransformationActivity',s("OBSOLETE",".","Activates","the","establishment","of","competence","for","transformation","."),4298573). assertion_content_comment('tOboGo_ActiveEvasionOfHostImmuneResponse',s("Any","mechanism","of","immune","avoidance","that","directly","affects","the","host","immune","system",",","e.g",".","blocking","any","stage","in","host","MHC","class","I","and","II","presentation",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4281431). assertion_content_comment('tOboGo_ActiveEvasionOfHostImmuneResponseViaRegulationOfHostAntigenProcessingAndPresentation',s("Any","mechanism","of","active","immune","avoidance","which","works","by","regulating","the","host","'","s","antigen","processing","or","presentation","pathways",",","e.g",".","by","blocking","any","stage","in","MHC","class","II","presentation",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4281434). assertion_content_comment('tOboGo_ActiveEvasionOfHostImmuneResponseViaRegulationOfHostComplementSystem',s("Any","mechanism","of","active","immune","avoidance","which","works","by","regulating","the","host","complement","system",",","e.g",".","by","possessing","complement","receptors","which","mediate","attachment","to",",","then","infection","of",",","host","macrophages",",","which","are","eventually","destroyed",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4317120). assertion_content_comment('tOboGo_ActiveEvasionOfHostImmuneResponseViaRegulationOfHostCytokineNetwork',s("Any","mechanism","of","active","immune","avoidance","which","works","by","regulating","host","cytokine","networks",",","e.g",".","by","secreting","proteins","that","mimic","cytokine","receptors","that","act","to","sequester","host","cytokines","and","inhibit","action",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4317108). assertion_content_comment('tOboGo_ActiveEvasionOfImmuneResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","avoids","the","immune","response","of","a","second","organism","which","directly","affects","the","second","organism","'","s","immune","system",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4281399). assertion_content_comment('tOboGo_ActiveEvasionOfImmuneResponseOfOtherOrganismViaRegulationOfAntigenProcessingAndPresentationInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","avoids","the","immune","response","of","a","second","organism","by","regulating","the","second","organism","'","s","antigen","processing","or","presentation","pathways",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4281440). assertion_content_comment('tOboGo_ActiveEvasionOfImmuneResponseOfOtherOrganismViaRegulationOfComplementSystemOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","avoids","the","immune","response","of","a","second","organism","by","regulating","the","second","organism","'","s","complement","system",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4281454). assertion_content_comment('tOboGo_ActiveEvasionOfImmuneResponseOfOtherOrganismViaRegulationOfCytokineNetworkOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","avoids","the","immune","response","of","a","second","organism","by","regulating","the","second","organism","'","s","cytokine","networks",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4281403). assertion_content_comment('tOboGo_ActiveEvasionOfSymbiontImmuneResponse',s("OBSOLETE",".","Any","mechanism","of","immune","avoidance","that","directly","affects","the","symbiont","immune","system",",","e.g",".","blocking","any","stage","in","symbiont","MHC","class","I","and","II","presentation",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282382). assertion_content_comment('tOboGo_ActiveEvasionOfSymbiontImmuneResponseViaRegulationOfSymbiontAntigenProcessingAndPresentation',s("OBSOLETE",".","Any","mechanism","of","active","immune","avoidance","which","works","by","regulating","the","symbiont","'","s","antigen","processing","or","presentation","pathways",",","e.g",".","by","blocking","any","stage","in","MHC","class","II","presentation",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282427). assertion_content_comment('tOboGo_ActiveEvasionOfSymbiontImmuneResponseViaRegulationOfSymbiontComplementSystem',s("OBSOLETE",".","Any","mechanism","of","active","immune","avoidance","which","works","by","regulating","the","symbiont","complement","system",",","e.g",".","by","possessing","complement","receptors","which","mediate","attachment","to",",","then","infection","of",",","symbiont","macrophages",",","which","are","eventually","destroyed",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282453). assertion_content_comment('tOboGo_ActiveEvasionOfSymbiontImmuneResponseViaRegulationOfSymbiontCytokineNetwork',s("OBSOLETE",".","Any","mechanism","of","active","immune","avoidance","which","works","by","regulating","symbiont","cytokine","networks",",","e.g",".","by","secreting","proteins","that","mimic","cytokine","receptors","that","act","to","sequester","symbiont","cytokines","and","inhibit","action",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282441). assertion_content_comment('tOboGo_ActiveInductionOfHostImmuneResponseByVirus',s("The","intentional",",","virally-encoded","stimulation","of","a","host","defense","response","to","viral","infection","."),4356559). assertion_content_comment('tOboGo_ActiveInductionOfHumoralImmuneResponseInHostByVirus',s("The","intentional",",","virally-encoded","stimulation","of","a","host","humoral","defense","response","to","viral","infection","."),4356562). assertion_content_comment('tOboGo_ActiveInductionOfInnateImmuneResponseInHostByVirus',s("The","intentional",",","virally-encoded","stimulation","of","an","innate","host","defense","response","to","viral","infection","."),4356604). assertion_content_comment('tOboGo_ActiveIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","an","ion","from","one","side","of","a","membrane","to","the","other","up","the","solute","'","s","concentration","gradient",".","This","is","carried","out","by","binding","the","solute","and","undergoing","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","."),4333081). assertion_content_comment('tOboGo_ActiveLargeUnchargedPolarMoleculeTransmembraneTransporterActivity',s("OBSOLETE",".","Catalysis","of","the","transfer","of","a","large","uncharged","polar","molecule","from","one","side","of","the","membrane","to","the","other",",","up","the","solute","'","s","concentration","gradient",",","by","binding","the","solute","and","undergoing","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","."),4333148). assertion_content_comment('tOboGo_ActiveSporeDispersalOnOrNearHost',s("Any","active","process","in","which","a","symbiont","disseminates","its","spores",",","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154503). assertion_content_comment('tOboGo_ActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","specific","substance","or","related","group","of","substances","from","one","side","of","a","membrane","to","the","other",",","up","the","solute","'","s","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","."),4020506). assertion_content_comment('tOboGo_ActivinABComplex',s("A","nonsteroidal","regulator",",","composed","of","two","covalently","linked","inhibin","beta","subunits","(","sometimes","known","as","activin","beta","or","activin/inhibin","beta",")",",","inhibin","beta-A","and","inhibin","beta-B","."),4385036). assertion_content_comment('tOboGo_ActivinAComplex',s("A","nonsteroidal","regulator",",","composed","of","two","covalently","linked","inhibin","beta-A","subunits","(","sometimes","known","as","activin","beta-A","or","activin/inhibin","beta-A",")"),4324641). assertion_content_comment('tOboGo_ActivinBComplex',s("A","nonsteroidal","regulator",",","composed","of","two","covalently","linked","inhibin","beta-B","subunits","(","sometimes","known","as","activin","beta-B","or","activin/inhibin","beta-B",")"),4324652). assertion_content_comment('tOboGo_ActivinBinding',s("Interacting","selectively","and","non-covalently","with","activin",",","a","dimer","of","inhibin-beta","subunits","."),4385017). assertion_content_comment('tOboGo_ActivinComplex',s("A","nonsteroidal","regulator",",","composed","of","two","covalently","linked","inhibin","beta","subunits",",","inhibin","beta-A","and","inhibin","beta-B","(","sometimes","known","as","activin","beta","or","activin/inhibin","beta",")","There","are","three","forms","of","activin","complex",",","activin","A",",","which","is","composed","of","2","inhibin","beta-A","subunits",",","activin","B",",","which","is","composed","of","2","inhibin","beta-B","subunits",",","and","activin","AB",",","which","is","composed","of","an","inhibin","beta-A","and","an","inhibin","beta-B","subunit","."),4103405). assertion_content_comment('tOboGo_ActivinInhibitorActivity',s("OBSOLETE",".","Acts","to","negatively","regulate","the","activity","of","activin",",","a","nonsteroidal","regulator","synthesized","in","the","pituitary","gland","and","gonads","that","stimulates","the","secretion","of","follicle-stimulating","hormone","."),4267582). assertion_content_comment('tOboGo_ActivinReceptorActivity',s("Combining","with","activin",",","one","of","two","gonadal","glycoproteins","related","to","transforming","growth","factor","beta",",","to","initiate","a","change","in","cell","activity","."),4265885). assertion_content_comment('tOboGo_ActivinReceptorActivityTypeII',s("Combining","with","activin","to","initiate","a","change","in","cell","activity",";","upon","ligand","binding",",","binds","to","and","catalyses","the","phosphorylation","of","a","type","I","activin","receptor","."),4304510). assertion_content_comment('tOboGo_ActivinReceptorActivityTypeI',s("Combining","with","activin-bound","type","II","activin","receptor","to","initiate","a","change","in","cell","activity",";","upon","binding",",","acts","as","a","downstream","transducer","of","activin","signals","."),4304500). assertion_content_comment('tOboGo_ActivinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","activin","receptor","."),4177492). assertion_content_comment('tOboGo_ActivinReceptorComplex',s("A","protein","complex","that","acts","as","an","activin","receptor",".","Heterodimeric","activin","receptors",",","comprising","one","Type","I","activin","receptor","and","one","Type","II","receptor","polypeptide",",","and","heterotrimeric","receptors","have","been","observed","."),4103416). assertion_content_comment('tOboGo_ActivinReceptorSignalingPathwayInvolvedInHeartJogging',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","activin","family","binding","to","a","cell","surface","receptor","and","contributing","to","the","process","of","heart","jogging","."),4133561). assertion_content_comment('tOboGo_ActivinReceptorSignalingPathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","activin","family","binding","to","a","cell","surface","receptor","."),4064077). assertion_content_comment('tOboGo_ActivinResponsiveFactorComplex',s("A","transcriptionally","active","complex","that","binds","to","an","activin","response","element","(","ARE",")","in","the","promoter","of","target","genes",",","and","is","composed","of","two","SMAD2","proteins",",","one","SMAD4","protein","and","a","Forkhead","activin","signal","transducer","(","FAST",")","transcription","factor","."),4334815). assertion_content_comment('tOboGo_ActivinSecretion',s("The","regulated","release","of","activin",",","a","nonsteroidal","regulator","composed","of","two","covalently","linked","beta","subunits",",","which","is","synthesized","in","the","pituitary","gland","and","gonads","and","stimulates","the","secretion","of","follicle-stimulating","hormone","."),4056144). assertion_content_comment('tOboGo_Activin',s("OBSOLETE",".","A","nonsteroidal","regulator",",","composed","of","two","covalently","linked","beta","subunits",",","that","is","synthesized","in","the","pituitary","gland","and","gonads","and","stimulates","the","secretion","of","follicle-stimulating","hormone","."),4302035). assertion_content_comment('tOboGo_ActomyosinActinPart',s("The","actin","part","of","any","complex","of","actin",",","myosin",",","and","accessory","proteins","."),4077687). assertion_content_comment('tOboGo_ActomyosinContractileRing',s("A","cytoskeletal","structure","composed","of","actin","filaments","and","myosin","that","forms","beneath","the","plasma","membrane","of","many","cells",",","including","animal","cells","and","yeast","cells",",","in","a","plane","perpendicular","to","the","axis","of","the","spindle",",","i.e",".","the","cell","division","plane",".","Ring","contraction","is","associated","with","centripetal","growth","of","the","membrane","that","divides","the","cytoplasm","of","the","two","daughter","cells",".","In","animal","cells",",","the","contractile","ring","is","located","inside","the","plasma","membrane","at","the","location","of","the","cleavage","furrow",".","In","budding","fungal","cells",",","e.g",".","mitotic","S",".","cerevisiae","cells",",","the","contractile","ring","forms","beneath","the","plasma","membrane","at","the","mother-bud","neck","before","mitosis","."),3971838). assertion_content_comment('tOboGo_ActomyosinMyosinComplexPart',s("The","myosin","part","of","any","complex","of","actin",",","myosin",",","and","accessory","proteins","."),4077697). assertion_content_comment('tOboGo_Actomyosin',s("Any","complex","of","actin",",","myosin",",","and","accessory","proteins","."),4077675). assertion_content_comment('tOboGo_ActomyosinStructureOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","containing","both","actin","and","myosin","or","paramyosin",".","The","myosin","may","be","organized","into","filaments","."),3978674). assertion_content_comment('tOboGo_AcuteInflammatoryResponse',s("Inflammation","which","comprises","a","rapid",",","short-lived",",","relatively","uniform","response","to","acute","injury","or","antigenic","challenge","and","is","characterized","by","accumulations","of","fluid",",","plasma","proteins",",","and","granulocytic","leukocytes",".","An","acute","inflammatory","response","occurs","within","a","matter","of","minutes","or","hours",",","and","either","resolves","within","a","few","days","or","becomes","a","chronic","inflammatory","response","."),3982912). assertion_content_comment('tOboGo_AcuteInflammatoryResponseToAntigenicStimulus',s("An","acute","inflammatory","response","to","an","antigenic","stimulus",".","An","acute","inflammatory","response","occurs","within","a","matter","of","minutes","or","hours",",","and","either","resolves","within","a","few","days","or","becomes","a","chronic","inflammatory","response","."),3982914). assertion_content_comment('tOboGo_AcylagmatineAmidaseActivity',s("Catalysis","of","the","reaction",":","N","(","4",")","-benzoylagmatine","+","H","(","2",")","O","=","agmatine","+","benzoate","."),4371996). assertion_content_comment('tOboGo_AcylBinding',s("Interacting","selectively","and","non-covalently","with","an","acyl","group",",","any","group","formally","derived","by","removal","of","the","hydroxyl","group","from","the","acid","function","of","a","carboxylic","acid","."),4218949). assertion_content_comment('tOboGo_AcylcarnitineHydrolaseActivity',s("Catalysis","of","the","reaction",":","O-acylcarnitine","+","H2O","=","a","fatty","acid","+","L-carnitine","."),4371979). assertion_content_comment('tOboGo_AcylCarnitineTransporterActivity',s("Enables","the","directed","movement","of","acyl","carnitine","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Acyl","carnitine","is","the","condensation","product","of","a","carboxylic","acid","and","carnitine","and","is","the","transport","form","for","a","fatty","acid","crossing","the","mitochondrial","membrane","."),4295526). assertion_content_comment('tOboGo_AcylCarnitineTransport',s("The","directed","movement","of","acyl","carnitine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Acyl","carnitine","is","the","condensation","product","of","a","carboxylic","acid","and","carnitine","and","is","the","transport","form","for","a","fatty","acid","crossing","the","mitochondrial","membrane","."),4228545). assertion_content_comment('tOboGo_AcylCarrierActivity',s("Enables","the","directed","movement","of","acyl","groups","into",",","out","of",",","within","or","between","cells","."),4345513). assertion_content_comment('tOboGo_AcylglycerolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","acylglycerol",",","any","mono-",",","di-","or","triester","of","glycerol","with","(","one","or","more",")","fatty","acids","."),4037002). assertion_content_comment('tOboGo_AcylglycerolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acylglycerol",",","any","mono-",",","di-","or","triester","of","glycerol","with","(","one","or","more",")","fatty","acids","."),4037698). assertion_content_comment('tOboGo_AcylglycerolHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","acylglycerol","within","an","organism","or","cell","."),4222141). assertion_content_comment('tOboGo_AcylglycerolKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","acylglycerol","=","ADP","+","acyl-sn-glycerol","3-phosphate","."),4371952). assertion_content_comment('tOboGo_AcylglycerolLipaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","acylglycerol","=","a","fatty","acid","+","glycerol","."),4368789). assertion_content_comment('tOboGo_AcylglycerolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","acylglycerol",",","any","mono-",",","di-","or","triester","of","glycerol","with","(","one","or","more",")","fatty","acids","."),4036949). assertion_content_comment('tOboGo_AcylglycerolTransport',s("The","directed","movement","of","an","acylglycerol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","An","acylglycerol","is","any","mono-",",","di-","or","triester","of","glycerol","with","(","one","or","more",")","fatty","acids","."),4359427). assertion_content_comment('tOboGo_AcyloxyacylHydrolaseActivity',s("Catalysis","of","the","reaction",":","3-","(","acyloxy",")","acyl","group","of","bacterial","toxin","=","3-hydroxyacyl","group","of","bacterial","toxin","+","a","fatty","acid","."),4269232). assertion_content_comment('tOboGo_AcylphosphataseActivity',s("Catalysis","of","the","reaction",":","an","acyl","phosphate","+","H2O","=","a","carboxylate","+","phosphate","."),4186305). assertion_content_comment('tOboGo_AcylpyruvateHydrolaseActivity',s("Catalysis","of","the","reaction",":","a","3-acylpyruvate","+","H2O","=","a","carboxylate","+","pyruvate","."),4371969). assertion_content_comment('tOboGo_AcyltransferaseActivity',s("Catalysis","of","the","generalized","reaction",":","acyl-carrier","+","reactant","=","acyl-reactant","+","carrier","."),4172663). assertion_content_comment('tOboGo_Ada2Gcn5Ada3TranscriptionActivatorComplex',s("A","multiprotein","complex","that","possesses","histone","acetyltransferase","and","is","involved","in","regulation","of","transcription",".","The","budding","yeast","complex","includes","Gcn5p",",","two","proteins","of","the","Ada","family",",","and","two","TBP-associate","proteins","(","TAFs",")",";","analogous","complexes","in","other","species","have","analogous","compositions",",","and","usually","contain","homologs","of","the","yeast","proteins","."),4220545). assertion_content_comment('tOboGo_AdamantanoneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","adamantanone",",","tricyclo","(","3.3.1.13",",","7",")","decanone",",","a","white","crystalline","solid","used","as","an","intermediate","for","microelectronics","in","the","production","of","photoresists","."),4238165). assertion_content_comment('tOboGo_AdamantanoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","adamantanone",",","tricyclo","(","3.3.1.13",",","7",")","decanone",",","a","white","crystalline","solid","used","as","an","intermediate","for","microelectronics","in","the","production","of","photoresists","."),4238160). assertion_content_comment('tOboGo_AdaptationOfRhodopsinMediatedSignaling',s("The","process","in","which","the","visual","system","can","modulate","its","sensitivity","and","response","to","light","stimuli","(","that","might","vary","over","more","than","6","magnitudes","in","intensity",")","without","response","saturation","."),4033797). assertion_content_comment('tOboGo_AdaptationOfSignalingPathwayByResponseToPheromoneInvolvedInConjugationWithCellularFusion',s("In","organisms","that","undergo","conjugation","with","cellular","fusion",",","the","process","resulting","in","desensitization","following","exposure","to","pheromone","stimulus","that","act","to","down-regulate","further","stimulation","or","block","initial","conjugation","responses",".","An","example","of","this","is","the","adaptation","to","pheromone","during","conjugation","with","cellular","fusion","in","Saccharomyces","cerevisiae","."),4360006). assertion_content_comment('tOboGo_AdaptationOfSignalingPathway',s("The","regulation","of","a","signal","transduction","pathway","in","response","to","a","stimulus","upon","prolonged","exposure","to","that","stimulus","."),3991183). assertion_content_comment('tOboGo_AdaptationToHostOsmoticEnvironment',s("OBSOLETE",".","The","responsive","adjustment","of","an","organism","to","the","osmotic","conditions","in","or","around","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4196273). assertion_content_comment('tOboGo_AdaptationToHostPHEnvironment',s("OBSOLETE",".","The","responsive","adjustment","of","an","organism","to","the","pH","conditions","in","or","around","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197554). assertion_content_comment('tOboGo_AdaptationToPheromoneInvolvedInConjugationWithMutualGeneticExchange',s("In","organisms","that","undergo","conjugation","without","cellular","fusion",",","the","process","resulting","in","desensitization","following","exposure","to","pheromone","stimulus","that","act","to","down-regulate","further","stimulation","or","block","initial","conjugation","responses","."),4363734). assertion_content_comment('tOboGo_AdaptiveImmuneResponseBasedOnSomaticRecombinationOfImmuneReceptorsBuiltFromImmunoglobulinSuperfamilyDomains',s("An","immune","response","based","on","directed","amplification","of","specific","receptors","for","antigen","produced","through","a","somatic","diversification","process","that","includes","somatic","recombination","of","germline","gene","segments","encoding","immunoglobulin","superfamily","domains",",","and","allowing","for","enhanced","responses","upon","subsequent","exposures","to","the","same","antigen","(","immunological","memory",")","Recombined","receptors","for","antigen","encoded","by","immunoglobulin","superfamily","domains","include","T","cell","receptors","and","immunoglobulins","(","antibodies",")","An","example","of","this","is","the","adaptive","immune","response","found","in","Mus","musculus","."),3982967). assertion_content_comment('tOboGo_AdaptiveImmuneResponse',s("An","immune","response","based","on","directed","amplification","of","specific","receptors","for","antigen","produced","through","a","somatic","diversification","process",",","and","allowing","for","enhanced","response","to","subsequent","exposures","to","the","same","antigen","(","immunological","memory",")"),3982964). assertion_content_comment('tOboGo_AdaxialAbaxialAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","adaxial","/","abaxial","axis",".","Adaxial","refers","to","being","situated","toward","an","axis","of","an","anatomical","structure",".","Abaxial","refers","to","being","situated","away","from","an","axis","of","an","anatomical","structure","."),4033314). assertion_content_comment('tOboGo_AdaxialAbaxialPatternFormation',s("The","regionalization","process","in","which","differences","in","cell","differentiation","along","the","adaxial/abaxial","are","generated",".","Adaxial","refers","to","being","situated","toward","an","axis","of","an","anatomical","structure",".","Abaxial","refers","to","being","situated","away","from","an","axis","of","an","anatomical","structure","."),4033311). assertion_content_comment('tOboGo_AdenineAdenineMispairBinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","an","A/A","mispair","."),4376856). assertion_content_comment('tOboGo_AdenineBinding',s("Interacting","selectively","and","non-covalently","with","adenine",",","a","purine","base","."),4374139). assertion_content_comment('tOboGo_AdenineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","adenine",",","6-aminopurine",",","one","of","the","five","main","bases","found","in","nucleic","acids","and","a","component","of","numerous","important","derivatives","of","its","corresponding","ribonucleoside",",","adenosine","."),4227614). assertion_content_comment('tOboGo_AdenineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","adenine",",","6-aminopurine",",","one","of","the","5","main","bases","found","in","nucleic","acids","and","a","component","of","numerous","important","derivatives","of","its","corresponding","ribonucleoside",",","adenosine","."),4227963). assertion_content_comment('tOboGo_AdenineCytosineMispairBinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","an","A/C","mispair","."),4329292). assertion_content_comment('tOboGo_AdenineDeaminaseActivity',s("Catalysis","of","the","reaction",":","adenine","+","H2O","=","hypoxanthine","+","NH3","."),4345524). assertion_content_comment('tOboGo_AdenineGuanineMispairBinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","an","A/G","mispair","."),4376806). assertion_content_comment('tOboGo_AdenineHypoxanthineAndTheirNucleosideSalvage',s("OBSOLETE",".","The","pathway","by","which","adenine",",","hypoxanthine","and","their","nucleosides","from","purine","nucleotides","breakdown","are","converted","back","to","purine","nucleotides",".","The","salvage","pathway","is","important","where","there","is","no","de-novo","purine","nucleotide","biosynthesis","."),4334044). assertion_content_comment('tOboGo_AdenineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","adenine",",","6-aminopurine",",","one","of","the","five","main","bases","found","in","nucleic","acids","and","a","component","of","numerous","important","derivatives","of","its","corresponding","ribonucleoside",",","adenosine","."),4227611). assertion_content_comment('tOboGo_AdenineNucleotideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","adenine","nucleotides","(","AMP",",","ADP",",","and","ATP",")","from","one","side","of","the","membrane","to","the","other","."),4181586). assertion_content_comment('tOboGo_AdenineNucleotideTransport',s("The","directed","movement","of","adenine","nucleotides",",","ATP",",","ADP",",","and/or","AMP",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4181625). assertion_content_comment('tOboGo_AdeninePhosphoribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","AMP","+","diphosphate","=","adenine","+","5-phospho-alpha-D-ribose","1-diphosphate","."),4186321). assertion_content_comment('tOboGo_AdenineSalvage',s("Any","process","that","generates","adenine",",","6-aminopurine",",","from","derivatives","of","it","without","de","novo","synthesis","."),4227620). assertion_content_comment('tOboGo_AdenineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","adenine",",","6-aminopurine",",","from","one","side","of","a","membrane","to","the","other","."),4295508). assertion_content_comment('tOboGo_AdenineTransport',s("The","directed","movement","of","adenine",",","6-aminopurine",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293835). assertion_content_comment('tOboGo_AdenohypophysisDevelopment',s("The","progression","of","the","adenohypophysis","over","time","from","its","initial","formation","until","its","mature","state",".","The","adenohypophysis","is","the","anterior","part","of","the","pituitary",".","It","secretes","a","variety","of","hormones","and","its","function","is","regulated","by","the","hypothalamus","."),4048029). assertion_content_comment('tOboGo_AdenohypophysisFormation',s("The","process","that","gives","rise","to","adenohypophysis",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","adenohypophysis","is","the","anterior","part","of","the","pituitary",".","It","secretes","a","variety","of","hormones","and","its","function","is","regulated","by","the","hypothalamus","."),4105665). assertion_content_comment('tOboGo_AdenohypophysisMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","adenohypophysis","are","generated","and","organized",".","The","adenohypophysis","is","the","anterior","part","of","the","pituitary",".","It","secretes","a","variety","of","hormones","and","its","function","is","regulated","by","the","hypothalamus","."),4105639). assertion_content_comment('tOboGo_AdenosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","adenosine",",","adenine","riboside",",","a","ribonucleoside","found","widely","distributed","in","cells","of","every","type","as","the","free","nucleoside","and","in","combination","in","nucleic","acids","and","various","nucleoside","coenzymes","."),4227547). assertion_content_comment('tOboGo_AdenosineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","adenosine",",","adenine","riboside",",","a","ribonucleoside","found","widely","distributed","in","cells","of","every","type","as","the","free","nucleoside","and","in","combination","in","nucleic","acids","and","various","nucleoside","coenzymes","."),4228111). assertion_content_comment('tOboGo_AdenosineDeaminaseActivity',s("Catalysis","of","the","reaction",":","adenosine","+","H2O","=","inosine","+","NH3","."),4192552). assertion_content_comment('tOboGo_AdenosineDeaminaseReaction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228004). assertion_content_comment('tOboGo_AdenosineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","adenosine","=","ADP","+","AMP","."),4213019). assertion_content_comment('tOboGo_AdenosineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","adenosine",",","adenine","riboside",",","a","ribonucleoside","found","widely","distributed","in","cells","of","every","type","as","the","free","nucleoside","and","in","combination","in","nucleic","acids","and","various","nucleoside","coenzymes","."),4158030). assertion_content_comment('tOboGo_AdenosineNucleosidaseActivity',s("Catalysis","of","the","reaction",":","adenosine","+","H2O","=","D-ribose","+","adenine","."),4371924). assertion_content_comment('tOboGo_AdenosineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","adenosine","receptor","."),4322448). assertion_content_comment('tOboGo_AdenosineReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","receptor","binding","to","extracellular","adenosine","and","transmitting","the","signal","to","a","heterotrimeric","G-protein","complex","to","initiate","a","change","in","cell","activity","."),4108430). assertion_content_comment('tOboGo_AdenosineSalvage',s("Any","process","that","generates","adenosine",",","adenine","riboside",",","from","derivatives","of","it","without","de","novo","synthesis","."),4227553). assertion_content_comment('tOboGo_AdenosineToInosineEditing',s("The","conversion","of","an","adenosine","residue","to","inosine","in","an","RNA","molecule","by","deamination","."),4224158). assertion_content_comment('tOboGo_AdenosineTransport',s("The","directed","movement","of","adenosine",",","adenine","riboside",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4053904). assertion_content_comment('tOboGo_AdenosylcobinamideHydrolaseActivity',s("Catalysis","of","the","reaction",":","adenosylcobinamide","+","H","(","2",")","O","=","(","R",")","-1-aminopropan-2-ol","+","adenosylcobyrate","."),4326169). assertion_content_comment('tOboGo_AdenosylcobinamideKinaseActivity',s("Catalysis","of","the","reaction",":","RTP","+","adenosylcobinamide","=","adenosylcobinamide","phosphate","+","RDP","(","where","RTP","is","either","ATP","or","GTP",")"),4325952). assertion_content_comment('tOboGo_AdenosylhomocysteinaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-homocysteine","+","H2O","=","adenosine","+","L-homocysteine","."),4213168). assertion_content_comment('tOboGo_AdenosylhomocysteineNucleosidaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-homocysteine","+","H2O","=","adenine","+","S-D-ribosyl-L-homocysteine","."),4249120). assertion_content_comment('tOboGo_AdenosylmethionineCyclotransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","=","S-methyl-5","'","-thioadenosine","+","homoserine","lactone","."),4371912). assertion_content_comment('tOboGo_AdenosylmethionineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","H","(","+",")","=","S-adenosylmethioninamine","+","CO","(","2",")"),4213062). assertion_content_comment('tOboGo_AdenosylmethionineHydrolaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","H","(","2",")","O","=","S-methyl-5","'","-thioadenosine","+","L-homoserine","+","H","(","+",")"),4372396). assertion_content_comment('tOboGo_AdenylateCyclaseActivatorActivity',s("Increases","the","activity","of","the","enzyme","that","catalyzes","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate","."),4335968). assertion_content_comment('tOboGo_AdenylateCyclaseActivity',s("Catalysis","of","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate","."),4213102). assertion_content_comment('tOboGo_AdenylateCyclaseBinding',s("Interacting","selectively","and","non-covalently","with","the","enzyme","adenylate","cyclase","."),4245872). assertion_content_comment('tOboGo_AdenylateCyclaseInhibitingMetabotropicGlutamateReceptorActivity',s("A","G-protein","coupled","receptor","that","binds","glutamate","and","inhibits","adenylate","cyclase","activity","."),4383998). assertion_content_comment('tOboGo_AdenylateCyclaseInhibitorActivity',s("Decreases","the","activity","of","the","enzyme","that","catalyzes","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate","."),4335977). assertion_content_comment('tOboGo_AdenylateCyclaseRegulatorActivity',s("Modulates","the","activity","of","the","enzyme","that","catalyzes","the","reaction",":","ATP","=","3","'",",","5","'","-cyclic","AMP","+","diphosphate","."),4335966). assertion_content_comment('tOboGo_AdenylateDeaminaseReaction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4227355). assertion_content_comment('tOboGo_AdenylateFormingEnzymeActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","substrate","+","ATP","=","substrate-AMP","+","diphosphate","."),4261976). assertion_content_comment('tOboGo_AdenylateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","AMP","=","2","ADP","."),4213121). assertion_content_comment('tOboGo_AdenylDeoxyribonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","an","adenyl","deoxyribonucleotide",",","any","compound","consisting","of","adenosine","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","deoxyribose","moiety","."),4331847). assertion_content_comment('tOboGo_AdenylNucleotideBinding',s("Interacting","selectively","and","non-covalently","with","adenyl","nucleotides",",","any","compound","consisting","of","adenosine","esterified","with","(","ortho",")","phosphate","."),4218680). assertion_content_comment('tOboGo_AdenylosuccinateSynthaseActivity',s("Catalysis","of","the","reaction",":","L-aspartate","+","GTP","+","IMP","=","N","(","6",")","-","(","1",",","2-dicarboxyethyl",")","-AMP","+","GDP","+","3","H","(","+",")","+","phosphate","."),4213047). assertion_content_comment('tOboGo_AdenylRibonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","an","adenyl","ribonucleotide",",","any","compound","consisting","of","adenosine","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","ribose","moiety","."),4218704). assertion_content_comment('tOboGo_AdenylylsulfataseActivity',s("Catalysis","of","the","reaction",":","5","'","-adenylyl","sulfate","+","H","(","2",")","O","=","AMP","+","2","H","(","+",")","+","sulfate","."),4372384). assertion_content_comment('tOboGo_AdenylylsulfateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","adenylylsulfate","=","ADP","+","3","'","-phosphoadenosine","5","'","-phosphosulfate","."),4213186). assertion_content_comment('tOboGo_AdenylyltransferaseActivity',s("Catalysis","of","the","transfer","of","an","adenylyl","group","to","an","acceptor","."),4174759). assertion_content_comment('tOboGo_AdherensJunctionAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","adherens","junction",".","An","adherens","junction","is","a","cell","junction","at","which","the","cytoplasmic","face","of","the","plasma","membrane","is","attached","to","actin","filaments","."),4354986). assertion_content_comment('tOboGo_AdherensJunctionMaintenance',s("The","maintenance","of","an","adherens","junction",".","An","adherens","junction","is","a","cell","junction","at","which","the","cytoplasmic","face","of","the","plasma","membrane","is","attached","to","actin","filaments","."),4355009). assertion_content_comment('tOboGo_AdherensJunctionOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","adherens","junction",".","An","adherens","junction","is","a","cell","junction","at","which","the","cytoplasmic","face","of","the","plasma","membrane","is","attached","to","actin","filaments","."),4354963). assertion_content_comment('tOboGo_AdherensJunction',s("A","cell","junction","at","which","anchoring","proteins","(","cadherins","or","integrins",")","extend","through","the","plasma","membrane","and","are","attached","to","actin","filaments","."),4008104). assertion_content_comment('tOboGo_AdhesinAutotransporterActivity',s("Catalysis","of","the","transfer","of","adhesin","from","the","periplasm","to","the","external","milieu",";","the","adhesin","and","the","porin","are","the","N-","and","C-terminal","regions","of","the","same","protein",",","respectively","."),4292423). assertion_content_comment('tOboGo_AdhesionOfSymbiontAppressoriumToHost',s("The","attachment","of","an","appressorium","of","the","symbiont","to","its","host","via","adhesion","molecules",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153951). assertion_content_comment('tOboGo_AdhesionOfSymbiontGerminationTubeToHost',s("The","attachment","of","a","germination","tube","of","the","symbiont","to","its","host","via","adhesion","molecules",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153929). assertion_content_comment('tOboGo_AdhesionOfSymbiontHaustoriumMotherCellToHost',s("The","attachment","of","a","haustorium","mother","cell","of","the","symbiont","to","its","host","via","adhesion","molecules",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153554). assertion_content_comment('tOboGo_AdhesionOfSymbiontHyphopodiumToHost',s("The","attachment","of","a","hyphopodium","of","the","symbiont","to","its","host","via","adhesion","molecules",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154209). assertion_content_comment('tOboGo_AdhesionOfSymbiontInfectionCushionToHost',s("The","attachment","of","an","infection","cushion","of","the","symbiont","to","its","host","via","adhesion","molecules",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153796). assertion_content_comment('tOboGo_AdhesionOfSymbiontInfectionStructureToHost',s("The","attachment","of","an","infection","structure","of","the","symbiont","to","its","host","via","adhesion","molecules",",","general","stickiness","etc.",",","either","directly","or","indirectly",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153550). assertion_content_comment('tOboGo_AdhesionOfSymbiontSporeToHost',s("The","attachment","of","a","spore","of","the","symbiont","to","its","host","via","adhesion","molecules",",","general","stickiness","etc",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153940). assertion_content_comment('tOboGo_AdhesionToHost',s("The","attachment","of","an","organism","to","its","host","via","adhesion","molecules",",","general","stickiness","etc.",",","either","directly","or","indirectly",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4079874). assertion_content_comment('tOboGo_AdhesionToOtherOrganismInvolvedInSymbioticInteraction',s("The","attachment","of","an","organism","to","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction",".","Adhesion","may","be","via","adhesion","molecules",",","general","stickiness","etc.",",","and","may","be","either","direct","or","indirect","."),4079871). assertion_content_comment('tOboGo_AdhesionToSymbiont',s("The","attachment","of","an","organism","to","its","symbiont","via","adhesion","molecules",",","general","stickiness","etc.",",","either","directly","or","indirectly",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282557). assertion_content_comment('tOboGo_AdhesiveExtracellularMatrixConstituent',s("OBSOLETE",".","A","constituent","of","the","extracellular","matrix","that","facilitates","attachment","of","cells","to","the","matrix","."),4306827). assertion_content_comment('tOboGo_AdipokineticHormoneBinding',s("Interacting","selectively","and","non-covalently","with","an","adipokinetic","hormone",".","Adipokinetic","hormones","(","AKHs",")","are","peptide","hormones","that","are","involved","in","the","mobilization","of","sugar","and","lipids","from","the","insect","fat","body","during","energy-requiring","activities","such","as","flight","and","locomotion",".","They","also","contribute","to","hemolymph","sugar","homeostasis","."),4071601). assertion_content_comment('tOboGo_AdipokineticHormoneReceptorActivity',s("Combining","with","an","adipokinetic","hormone","to","initiate","a","change","in","cell","activity",".","Adipokinetic","hormones","(","AKHs",")","are","peptide","hormones","that","are","involved","in","the","mobilization","of","sugar","and","lipids","from","the","insect","fat","body","during","energy-requiring","activities","such","as","flight","and","locomotion",".","They","also","contribute","to","hemolymph","sugar","homeostasis","."),4071581). assertion_content_comment('tOboGo_AdipokineticHormoneReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","adipokinetic","hormone","receptor",".","Adipokinetic","hormones","(","AKHs",")","are","peptide","hormones","that","are","involved","in","the","mobilization","of","sugar","and","lipids","from","the","insect","fat","body","during","energy-requiring","activities","such","as","flight","and","locomotion",".","They","also","contribute","to","hemolymph","sugar","homeostasis","."),4073732). assertion_content_comment('tOboGo_AdiponectinBinding',s("Interacting","selectively","and","non-covalently","with","adiponectin",",","a","protein","hormone","produced","by","adipose","tissue","that","modulates","a","number","of","metabolic","processes",",","including","glucose","regulation","and","fatty","acid","catabolism","."),4222170). assertion_content_comment('tOboGo_AdiponectinSecretion',s("The","regulated","release","of","adiponectin",",","a","protein","hormone",",","by","adipose","tissue","."),4133310). assertion_content_comment('tOboGo_AdiposeTissueDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","adipose","tissue","over","time",",","from","its","formation","to","the","mature","structure",".","Adipose","tissue","is","specialized","tissue","that","is","used","to","store","fat","."),4111782). assertion_content_comment('tOboGo_ADPBinding',s("Interacting","selectively","and","non-covalently","with","ADP",",","adenosine","5","'","-diphosphate","."),4325558). assertion_content_comment('tOboGo_ADPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ADP",",","adenosine","5","'","-diphosphate","."),4227889). assertion_content_comment('tOboGo_ADPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ADP",",","adenosine","5","'","-diphosphate","."),4348070). assertion_content_comment('tOboGo_ADPDeaminaseActivity',s("Catalysis","of","the","reaction",":","ADP","+","H2O","=","IDP","+","NH3","."),4372411). assertion_content_comment('tOboGo_ADPDimethylallyltransferaseActivity',s("Catalysis","of","the","reaction",":","delta2-isopentenyl","diphosphate","+","ADP","=","diphosphate","+","N6-","(","delta","(","2",")","-isopentenyl",")","adenosine","5","'","-diphosphate","."),4191224). assertion_content_comment('tOboGo_ADPGPyrophosphorylaseComplex',s("Complex","that","possesses","ADPG","pyrophosphorylase","activity",".","In","all","organisms","where","it","has","been","found",",","the","complex","is","a","tetramer",".","In","bacteria",",","it","is","a","homotetramer",".","In","plants",",","the","complex","is","a","heterotetramer","composed","small","and","large","subunits","."),4061511). assertion_content_comment('tOboGo_ADPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ADP",",","adenosine","5","'","-diphosphate","."),4227775). assertion_content_comment('tOboGo_ADPPhosphorylation',s("The","process","of","introducing","a","phosphate","group","into","ADP",",","adenosine","diphosphate",",","to","produce","ATP","."),4229264). assertion_content_comment('tOboGo_ADPReceptorActivity',s("Combining","with","ADP","to","initiate","a","change","in","cell","activity",".","ADP","receptors","are","present","at","the","surface","of","platelets",",","where","they","are","involved","in","platelet","aggregation","."),4383562). assertion_content_comment('tOboGo_ADPReductaseActivity',s("Catalysis","of","the","reaction",":","dADP","+","thioredoxin","disulfide","+","H2O","=","ADP","+","thioredoxin","."),4227314). assertion_content_comment('tOboGo_ADPReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4227318). assertion_content_comment('tOboGo_ADPTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","ADP",",","adenosine","diphosphate",",","from","one","side","of","a","membrane","to","the","other","."),4295613). assertion_content_comment('tOboGo_ADPTransport',s("The","directed","movement","of","ADP",",","adenosine","diphosphate",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293936). assertion_content_comment('tOboGo_AdrenalChromaffinCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","structural","and/or","functional","features","of","an","adrenal","chromaffin","cell",".","An","adrenal","chromaffin","cell","is","a","neuroendocrine","cell","that","stores","epinephrine","secretory","vesicles","."),4135321). assertion_content_comment('tOboGo_AdrenalCortexDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","adrenal","cortex","over","time",",","from","its","formation","to","the","mature","structure",".","The","adrenal","cortex","is","located","at","the","periphery","of","the","adrenal","gland","and","controls","glucose","and","electrolyte","metabolism",",","response","to","stress","and","sexual","development","through","the","production","of","different","classes","of","steroid","hormones","(","glucocorticoids",",","mineralocorticoids","and","androgens",")"),4081205). assertion_content_comment('tOboGo_AdrenalCortexFormation',s("The","process","that","gives","rise","to","the","adrenal","cortex",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","adrenogonadal","primordium","from","which","the","adrenal","cortex","is","formed","derives","from","a","condensation","of","coelomic","epithelial","cells","(","the","urogenital","ridge",";","the","same","structure","from","which","gonads","and","kidney","also","originate",")"),4081216). assertion_content_comment('tOboGo_AdrenalGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","adrenal","gland","over","time",",","from","its","formation","to","the","mature","structure",".","This","gland","can","either","be","a","discrete","structure","located","bilaterally","above","each","kidney",",","or","a","cluster","of","cells","in","the","head","kidney","that","perform","the","functions","of","the","adrenal","gland",".","In","either","case",",","this","organ","consists","of","two","cells","types",",","aminergic","chromaffin","cells","and","steroidogenic","cortical","cells","."),4048240). assertion_content_comment('tOboGo_AdrenergicReceptorActivity',s("Combining","with","epinephrine","or","norepinephrine","to","initiate","a","change","in","cell","activity","."),4197866). assertion_content_comment('tOboGo_AdrenergicReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","adrenergic","receptor","."),4322468). assertion_content_comment('tOboGo_AdrenergicReceptorSignalingPathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","an","adrenergic","receptor","binding","to","one","of","its","physiological","ligands","."),4125480). assertion_content_comment('tOboGo_Adrenocorticotropin',s("OBSOLETE",".","A","polypeptide","hormone","which","stimulates","the","adrenal","cortex","to","synthesize","and","secrete","glucocorticoid","hormones","."),4268248). assertion_content_comment('tOboGo_AdrenomedullinReceptorActivity',s("Combining","with","adrenomedullin","to","initiate","a","change","in","cell","activity","."),4383504). assertion_content_comment('tOboGo_AdrenomedullinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","adrenomedullin","receptor","."),4323108). assertion_content_comment('tOboGo_AdultBehavior',s("Behavior","in","a","fully","developed","and","mature","organism","."),4115062). assertion_content_comment('tOboGo_AdultBehaviorSensuInsecta',s("OBSOLETE",".","Behavior","in","a","fully","developed","and","mature","organism",",","as","seen","in","insects","."),4246879). assertion_content_comment('tOboGo_AdultEyePhotoreceptorDevelopmentSensuDrosophila',s("OBSOLETE",".","Development","of","a","photoreceptor",",","a","receptor","that","responds","to","light",",","in","the","adult","Drosophila","eye","."),4383420). assertion_content_comment('tOboGo_AdultFatBodyDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","adult","fat","body","over","time",",","from","its","formation","to","the","mature","structure",".","Larval","fat","body","cells","that","remain","at","eclosion","degenerate","in","the","first","2","to","4","days","of","adult","life",",","leaving","behind","the","smaller","cells","of","the","adult","fat","body","."),4234534). assertion_content_comment('tOboGo_AdultFeedingBehaviorSensuInsecta',s("OBSOLETE",".","Feeding","behavior","in","a","fully","developed","and","mature","organism",",","as","described","in","insects","."),4310745). assertion_content_comment('tOboGo_AdultFeedingBehavior',s("Feeding","behavior","in","a","fully","developed","and","mature","organism","."),4255105). assertion_content_comment('tOboGo_AdultForagingBehavior',s("Behavior","by","which","an","adult","locates","food","."),4161088). assertion_content_comment('tOboGo_AdultHeartDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","adult","heart","over","time",",","from","its","formation","to","the","mature","structure","."),4234506). assertion_content_comment('tOboGo_AdultLocomotoryBehavior',s("Locomotory","behavior","in","a","fully","developed","and","mature","organism","."),4115067). assertion_content_comment('tOboGo_AdultSalivaryGlandBoundarySpecification',s("Determination","in","an","adult","organism","of","where","the","salivary","gland","forms",",","the","total","number","of","salivary","gland","cells","and","how","many","cells","are","allocated","to","each","of","the","specialised","cell","types","within","the","salivary","gland","."),4091292). assertion_content_comment('tOboGo_AdultSalivaryGlandMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","adult","salivary","gland","are","generated","and","organized","."),4234705). assertion_content_comment('tOboGo_AdultSomaticMuscleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","adult","somatic","muscle","over","time",",","from","its","formation","to","the","mature","structure","."),4234525). assertion_content_comment('tOboGo_AdultVisceralMuscleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","adult","visceral","muscle","over","time",",","from","its","formation","to","the","mature","structure","."),4234516). assertion_content_comment('tOboGo_AdultWalkingBehavior',s("The","actions","or","reactions","of","an","adult","relating","to","the","progression","of","that","organism","along","the","ground","by","the","process","of","lifting","and","setting","down","each","leg","."),4234976). assertion_content_comment('tOboGo_AdventitiousRootDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","adventitious","root","over","time",",","from","its","formation","to","the","mature","structure",".","Adventitious","roots","are","post-embryonic","roots","that","develop","from","the","plant","shoot","."),4330703). assertion_content_comment('tOboGo_AdventitiousSeptum',s("A","cell","septum","whose","formation","is","independent","of","nuclear","division","."),4363215). assertion_content_comment('tOboGo_AdventurousGlidingMotility',s("A","process","involved","in","the","controlled","movement","of","a","bacterial","cell","powered","by","the","rearward","secretion","of","carbohydrate","slime","."),4307260). assertion_content_comment('tOboGo_AeciosporeFormation',s("The","process","in","which","a","dikaryotic","spore","of","typically","a","rust","fungus","is","produced","in","an","aecium",";","in","heteroecious","rusts",",","the","aeciospore","is","a","spore","stage","that","infects","the","alternate","host","."),4148583). assertion_content_comment('tOboGo_AeciumDevelopment',s("The","process","in","which","a","cup-like","structure","containing","chains","of","aeciospores","is","formed",".","This","is","characteristic","of","the","rust","fungus","and","typically",",","the","first","dikaryotic","spores","(","aeciospores",")","are","produced","in","the","aecium","."),4148414). assertion_content_comment('tOboGo_AerenchymaFormation',s("The","process","that","gives","rise","to","aerenchyma",",","parenchyma","tissue","containing","particularly","large","intercellular","spaces","of","schizogenous","or","lysigenous","origin",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4336538). assertion_content_comment('tOboGo_AerobactinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aerobactin","(","C22H36N4O13",")",",","a","hydroxamate","iron","transport","compound",".","It","is","a","conjugate","of","6-","(","N-acetyl-N-hydroxylamine",")","-2-aminohexanoic","acid","and","citric","acid","."),4238736). 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assertion_content_comment('tOboGo_AerobicNitrilotriacetateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitrilotriacetate",",","the","aminotricarboxylic","acid","N","(","CH2COO-",")","3",",","that","occur","in","the","presence","of","oxygen","."),4272227). assertion_content_comment('tOboGo_AerobicOrganosiliconMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organosilicons",",","organic","compounds","that","contain","silicon",",","in","the","presence","of","oxygen","."),4272655). assertion_content_comment('tOboGo_AerobicRespiration',s("The","enzymatic","release","of","energy","from","organic","compounds","(","especially","carbohydrates","and","fats",")","which","requires","oxygen","as","the","terminal","electron","acceptor","."),4010271). 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assertion_content_comment('tOboGo_AerotaxisInHostEnvironment',s("The","movement","of","a","motile","cell","or","organism","in","response","to","environmental","oxygen","on",",","within","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197419). assertion_content_comment('tOboGo_AerotaxisInHost',s("The","movement","of","a","motile","cell","or","organism","in","response","to","environmental","oxygen","within","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197475). 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assertion_content_comment('tOboGo_AgglutinationInvolvedInConjugation',s("The","aggregation","or","adhesion","of","compatible","mating","types","via","complementary","cell-cell","interactions","prior","to","the","formation","of","irreversible","cellular","contacts","during","conjugation","."),3977555). assertion_content_comment('tOboGo_AgglutinationInvolvedInConjugationWithCellularFusion',s("During","conjugation","with","cellular","fusion",",","the","aggregation","or","adhesion","of","compatible","mating","types","via","complementary","cell-cell","interactions",".","An","example","of","this","process","is","agglutination","in","Saccharomyces","cerevisiae","."),3977559). assertion_content_comment('tOboGo_AgglutinationInvolvedInConjugationWithMutualGeneticExchange',s("During","conjugation","without","cellular","fusion",",","the","aggregation","or","adhesion","of","compatible","mating","types","via","complementary","cell-cell","interactions","."),3977765). assertion_content_comment('tOboGo_AggregationInvolvedInSorocarpDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","aggregate","over","time",",","from","its","formation","to","the","point","when","a","slug","is","formed",".","Aggregate","development","begins","in","response","to","starvation","and","continues","by","the","chemoattractant-mediated","movement","of","cells","toward","each","other",".","The","aggregate","is","a","multicellular","structure","that","gives","rise","to","the","slug","."),4062445). assertion_content_comment('tOboGo_AggresomeAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","aggresome",";","requires","the","microtubule","cytoskeleton","and","dynein","."),4178775). assertion_content_comment('tOboGo_Aggresome',s("An","inclusion","body","formed","by","dynein-dependent","retrograde","transport","of","an","aggregated","protein","on","microtubules","."),4303793). assertion_content_comment('tOboGo_AggressiveBehavior',s("A","behavioral","interaction","between","organisms","in","which","one","organism","has","the","intention","of","inflicting","physical","damage","on","another","individual","."),4374627). assertion_content_comment('tOboGo_AgingDependentSterilitySensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310461). assertion_content_comment('tOboGo_AgingDependentSterilitySensuSaccharomyces',s("OBSOLETE",".","A","haploid","'","s","inability","to","mate","due","to","the","loss","of","silencing","at","the","mating-type","loci",",","resulting","in","expression","of","both","of","the","normally","silent","mating-type","cassettes","."),4234777). 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assertion_content_comment('tOboGo_Alanine_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","alanine","(","out",")","+","Na","+","(","out",")","=","alanine","(","in",")","+","Na","+","(","in",")"),4290213). assertion_content_comment('tOboGo_AlanineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","alanine","from","one","side","of","a","membrane","to","the","other",".","Alanine","is","2-aminopropanoic","acid","."),4290211). assertion_content_comment('tOboGo_AlanineTransport',s("The","directed","movement","of","alanine",",","2-aminopropanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293738). assertion_content_comment('tOboGo_AlanopineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2",",","2","'","-iminodipropanoate","+","H","(","2",")","O","+","NAD","(","+",")","=","L-alanine","+","H","(","+",")","+","NADH","+","pyruvate","."),4372368). assertion_content_comment('tOboGo_AlanylphosphatidylglycerolSynthaseActivity',s("Catalysis","of","the","reaction",":","L-alanyl-tRNA","+","phosphatidylglycerol","=","tRNA","+","3-O-L-alanyl-1-O-phosphatidylglycerol","."),4372289). assertion_content_comment('tOboGo_AlbendazoleMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","albendazole","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","albendazole","S-oxide","+","H","(","2",")","O","+","NADP","(","+",")"),4372277). assertion_content_comment('tOboGo_AlcoholBinding',s("Interacting","selectively","and","non-covalently","with","an","alcohol",",","any","of","a","class","of","alkyl","compounds","containing","a","hydroxyl","group","."),4177334). assertion_content_comment('tOboGo_AlcoholBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","alcohols",",","any","of","a","class","of","compounds","containing","one","or","more","hydroxyl","groups","attached","to","a","saturated","carbon","atom","."),4010048). assertion_content_comment('tOboGo_AlcoholCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","alcohols",",","any","of","a","class","of","compounds","containing","one","or","more","hydroxyl","groups","attached","to","a","saturated","carbon","atom","."),3992077). assertion_content_comment('tOboGo_AlcoholDehydrogenaseAcceptorActivity',s("Catalysis","of","the","reaction",":","a","primary","alcohol","+","acceptor","=","an","aldehyde","+","reduced","acceptor","."),4277476). assertion_content_comment('tOboGo_AlcoholDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","an","alcohol","+","NAD","+","=","an","aldehyde","or","ketone","+","NADH","+","H","+"),4191389). assertion_content_comment('tOboGo_AlcoholDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","an","alcohol","+","NADP","+","=","an","aldehyde","+","NADPH","+","H","+"),4191362). assertion_content_comment('tOboGo_AlcoholMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","alcohols",",","any","of","a","class","of","compounds","containing","one","or","more","hydroxyl","groups","attached","to","a","saturated","carbon","atom","."),3981680). assertion_content_comment('tOboGo_AlcoholOxidaseActivity',s("Catalysis","of","the","reaction",":","a","primary","alcohol","+","O2","=","an","aldehyde","+","H2O2","."),4372265). assertion_content_comment('tOboGo_AlcoholSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","an","alcohol","=","adenosine","3","'",",","5","'","-bisphosphate","+","an","alkyl","sulfate","."),4183078). assertion_content_comment('tOboGo_AlcoholTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","an","alcohol","from","one","side","of","the","membrane","to","the","other",".","An","alcohol","is","any","carbon","compound","that","contains","a","hydroxyl","group","."),4179021). assertion_content_comment('tOboGo_AldarateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","aldarate","from","one","side","of","the","membrane","to","the","other","."),4292802). assertion_content_comment('tOboGo_AldarateTransport',s("The","directed","movement","of","aldarate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290801). assertion_content_comment('tOboGo_AldaricAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aldaric","acid",",","any","dicarboxylic","acid","formed","by","oxidation","of","by","the","terminal","groups","of","an","aldose","to","carboxyl","group","."),4239365). assertion_content_comment('tOboGo_AldaricAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","aldaric","acid",",","any","dicarboxylic","acid","formed","by","oxidation","of","by","the","terminal","groups","of","an","aldose","to","carboxyl","group","."),4239396). assertion_content_comment('tOboGo_AldaricAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","aldaric","acid",",","any","dicarboxylic","acid","formed","by","oxidation","of","by","the","terminal","groups","of","an","aldose","to","carboxyl","group","."),4239340). assertion_content_comment('tOboGo_AldehydeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aldehydes",",","any","organic","compound","with","the","formula","R-CH","=","O","."),4230344). assertion_content_comment('tOboGo_AldehydeCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","aldehydes",",","any","organic","compound","with","the","formula","R-CH","=","O","."),4238491). assertion_content_comment('tOboGo_AldehydeDecarbonylaseActivity',s("Catalysis","of","the","reaction",":","a","C","(","n",")","aldehyde","=","C","(","n-1",")","alkane","+","CO","."),4169478). assertion_content_comment('tOboGo_AldehydeDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","an","aldehyde","+","NAD","+","+","H2O","=","an","acid","+","NADH","+","H","+"),4213319). assertion_content_comment('tOboGo_AldehydeDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","an","aldehyde","+","NAD","(","P",")","+","+","H2O","=","an","acid","+","NAD","(","P",")","H","+","H","+"),4213350). assertion_content_comment('tOboGo_AldehydeFerredoxinOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","an","aldehyde","+","H2O","+","2","oxidized","ferredoxin","=","an","acid","+","2","H","+","+","2","reduced","ferredoxin","."),4342543). assertion_content_comment('tOboGo_AldehydeOxidaseActivity',s("Catalysis","of","the","reaction",":","an","aldehyde","+","H2O","+","O2","=","a","carboxylic","acid","+","hydrogen","peroxide","."),4213338). assertion_content_comment('tOboGo_AlditolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","alditols",",","any","polyhydric","alcohol","derived","from","the","acyclic","form","of","a","monosaccharide","by","reduction","of","its","aldehyde","or","keto","group","to","an","alcoholic","group","."),4010589). assertion_content_comment('tOboGo_AlditolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","alditols",",","any","polyhydric","alcohol","derived","from","the","acyclic","form","of","a","monosaccharide","by","reduction","of","its","aldehyde","or","keto","group","to","an","alcoholic","group","."),4225021). 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assertion_content_comment('tOboGo_AldonateTransport',s("The","directed","movement","of","aldonate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4064680). assertion_content_comment('tOboGo_AldonicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aldonic","acid",",","a","monocarboxylic","acid","with","a","chain","of","three","or","more","carbon","atoms",",","derived","from","an","aldose","by","oxidation","of","the","aldehydic","group","."),4351521). assertion_content_comment('tOboGo_AldonicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","aldonic","acid",",","a","monocarboxylic","acid","with","a","chain","of","three","or","more","carbon","atoms",",","derived","from","an","aldose","by","oxidation","of","the","aldehydic","group","."),4242402). assertion_content_comment('tOboGo_AldonicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","aldonic","acid",",","a","monocarboxylic","acid","with","a","chain","of","three","or","more","carbon","atoms",",","derived","from","an","aldose","by","oxidation","of","the","aldehydic","group","."),4242385). assertion_content_comment('tOboGo_AldosteroneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aldosterone",",","a","corticosteroid","hormone","that","is","produced","by","the","zona","glomerulosa","of","the","adrenal","cortex","and","regulates","salt","(","sodium","and","potassium",")","and","water","balance","."),4056010). assertion_content_comment('tOboGo_AldosteroneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","aldosterone",",","a","corticosteroid","hormone","that","is","produced","by","the","zona","glomerulosa","of","the","adrenal","cortex","and","regulates","salt","(","sodium","and","potassium",")","and","water","balance","."),4333740). assertion_content_comment('tOboGo_AldosteroneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","aldosterone",",","a","corticosteroid","hormone","that","is","produced","by","the","zona","glomerulosa","of","the","adrenal","cortex","and","regulates","salt","(","sodium","and","potassium",")","and","water","balance","."),4056007). assertion_content_comment('tOboGo_AldoximeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","aldoximes",",","compounds","derived","by","the","reaction","of","an","aldose","with","hydroxylamine",",","thus","containing","the","aldoxime","group","-HC","=","NOH","."),4240523). assertion_content_comment('tOboGo_AleuroneGrainLumen',s("The","volume","enclosed","by","the","membrane","of","an","aleurone","grain","."),4074496). assertion_content_comment('tOboGo_AleuroneGrainMembrane',s("The","lipid","bilayer","surrounding","an","aleurone","grain","."),4067414). assertion_content_comment('tOboGo_AleuroneGrain',s("A","membrane-bounded","storage","granule","found","in","cells","of","the","aleurone","layer","in","plants",";","contains","either","a","protein","matrix",",","protein-carbohydrate","bodies","and/or","globoids",".","Aleurone","grains","are","formed","by","the","vacuole",",","rough","endoplasmic","reticulum","and","dictyosomes","."),4067403). assertion_content_comment('tOboGo_AlginateSynthaseActivity',s("Catalysis","of","the","reaction",":","GDP-D-mannuronate","+","alginate","(","n",")","=","GDP","+","alginate","(","n","+","1",")"),4372173). assertion_content_comment('tOboGo_AlginicAcidAcetylation',s("The","addition","of","O-acetyl","ester","groups","to","alginic","acid",",","a","linear","polymer","of","D-mannuronate","and","L-guluronate","."),4183812). assertion_content_comment('tOboGo_AlginicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","alginic","acid",",","a","hydrophilic","polysaccharide","occurring","in",",","for","example",",","the","cell","walls","of","brown","algae","(","brown","seaweeds",")"),4313825). 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assertion_content_comment('tOboGo_AliphaticAldoximeDehydrataseActivity',s("Catalysis","of","the","reaction",":","an","aliphatic","aldoxime","=","an","aliphatic","nitrile","+","H2O","."),4360670). assertion_content_comment('tOboGo_AliphaticNitrilaseActivity',s("Catalysis","of","the","reaction",":","R-CN","+","H2O","=","R-COOH","+","NH3","."),4274599). assertion_content_comment('tOboGo_AlkaliMetalIonBinding',s("Interacting","selectively","and","non-covalently","with","any","alkali","metal","ion",";","alkali","metals","are","those","elements","in","group","Ia","of","the","periodic","table",",","with","the","exception","of","hydrogen","."),4307411). assertion_content_comment('tOboGo_AlkalinePhosphataseActivity',s("Catalysis","of","the","reaction",":","an","orthophosphoric","monoester","+","H2O","=","an","alcohol","+","phosphate",",","with","an","alkaline","pH","optimum","."),4213374). assertion_content_comment('tOboGo_AlkaloidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","alkaloids",",","nitrogen-containing","natural","products","which","are","not","otherwise","classified","as","nonprotein","amino","acids",",","amines",",","peptides",",","amines",",","cyanogenic","glycosides",",","glucosinolates",",","cofactors",",","phytohormones",",","or","primary","metabolite","(","such","as","purine","or","pyrimidine","bases",")"),4046160). assertion_content_comment('tOboGo_AlkaloidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","alkaloids",",","nitrogen","containing","natural","products","not","otherwise","classified","as","peptides",",","nonprotein","amino","acids",",","amines",",","cyanogenic","glycosides",",","glucosinolates",",","cofactors",",","phytohormones","or","primary","metabolites","(","such","as","purine","or","pyrimidine","bases",")"),4166653). assertion_content_comment('tOboGo_AlkaloidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","alkaloids",",","nitrogen","containing","natural","products","which","are","not","otherwise","classified","as","peptides",",","nonprotein","amino","acids",",","amines",",","cyanogenic","glycosides",",","glucosinolates",",","cofactors",",","phytohormones","or","primary","metabolites","(","such","as","purine","or","pyrimidine","bases",")"),4046156). assertion_content_comment('tOboGo_AlkaneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","alkane",",","any","acyclic","branched","or","unbranched","hydrocarbon","having","the","general","formula","CnH2n","+","2","."),4239900). assertion_content_comment('tOboGo_AlkaneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","an","alkane",",","any","acyclic","branched","or","unbranched","hydrocarbon","having","the","general","formula","CnH2n","+","2","."),4325052). assertion_content_comment('tOboGo_AlkanesulfonateBinding',s("Interacting","selectively","and","non-covalently","with","alkanesulfonates",",","the","anion","of","alkanesulfonic","acids",",","sulfonic","acid","derivatives","containing","an","aliphatic","hydrocarbon","group","."),4318657). assertion_content_comment('tOboGo_AlkanesulfonateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","alkanesulfonates",",","the","anion","of","alkanesulfonic","acids",",","sulfonic","acid","derivatives","containing","an","aliphatic","hydrocarbon","group","."),4349963). assertion_content_comment('tOboGo_AlkanesulfonateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","alkanesulfonates",",","the","anion","of","alkanesulfonic","acids",",","sulfonic","acid","derivatives","containing","an","aliphatic","hydrocarbon","group","."),4349762). assertion_content_comment('tOboGo_AlkanesulfonateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","alkanesulfonates",",","the","anion","of","alkanesulfonic","acids",",","sulfonic","acid","derivatives","containing","an","aliphatic","hydrocarbon","group","."),4244479). assertion_content_comment('tOboGo_AlkanesulfonateMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","an","alkanesulfonate","+","O2","+","FMNH2","=","an","aldehyde","+","sulfite","+","H2O","+","FMN","."),4252299). assertion_content_comment('tOboGo_AlkanesulfonateTransporterActivity',s("Enables","the","directed","movement","of","alkanesulfonate","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4316305). assertion_content_comment('tOboGo_AlkanesulfonateTransport',s("The","directed","movement","of","an","alkanesulfonate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Alkanesulfonates","are","organic","esters","or","salts","of","sulfonic","acid","containing","an","aliphatic","hydrocarbon","radical","."),4315931). assertion_content_comment('tOboGo_AlkaneTransporterActivity',s("Enables","the","directed","movement","of","alkanes","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Alkanes","are","saturated","aliphatic","hydrocarbon","compounds","."),4293413). assertion_content_comment('tOboGo_AlkaneTransport',s("The","directed","movement","of","alkanes","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Alkanes","are","saturated","aliphatic","hydrocarbon","compounds","."),4294145). assertion_content_comment('tOboGo_AlkeneBinding',s("Interacting","selectively","and","non-covalently","with","an","alkene",",","any","acyclic","branched","or","unbranched","hydrocarbon","having","one","carbon-carbon","double","bond","and","the","general","formula","CnH2n","."),4158703). assertion_content_comment('tOboGo_AlkeneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","alkene",",","any","acyclic","branched","or","unbranched","hydrocarbon","having","one","carbon-carbon","double","bond","and","the","general","formula","CnH2n","."),4031004). assertion_content_comment('tOboGo_AlkeneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","an","alkene",",","any","acyclic","branched","or","unbranched","hydrocarbon","having","one","carbon-carbon","double","bond","and","the","general","formula","CnH2n","."),4240476). assertion_content_comment('tOboGo_AlkeneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","propene","+","NADH","+","H","+","+","O2","=","1",",","2-epoxypropane","+","NAD","+","+","H2O","."),4276267). assertion_content_comment('tOboGo_AlkenylglycerophosphocholineHydrolaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","1-","(","1-alkenyl",")","-sn-glycero-3-phosphocholine","=","L-1-glycero-3-phosphocholine","+","an","aldehyde","."),4369995). assertion_content_comment('tOboGo_AlkenylglycerophosphoethanolamineHydrolaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","1-","(","1-alkenyl",")","-sn-glycero-3-phosphoethanolamine","=","sn-glycero-3-phosphoethanolamine","+","an","aldehyde","."),4370006). assertion_content_comment('tOboGo_AlkylacetylglycerophosphataseActivity',s("Catalysis","of","the","reaction",":","1-alkyl-2-acetyl-sn-glycerol","3-phosphate","+","H","(","2",")","O","=","2-acetyl-1-alkyl-sn-glycerol","+","phosphate","."),4372227). assertion_content_comment('tOboGo_AlkylamidaseActivity',s("Catalysis","of","the","reaction",":","N-methylhexanamide","+","H","(","2",")","O","=","hexanoate","+","methylammonium","."),4372699). assertion_content_comment('tOboGo_AlkylatedDNABinding',s("Interacting","selectively","and","non-covalently","with","alkylated","residues","in","DNA","."),4329323). assertion_content_comment('tOboGo_AlkylglycerolKinaseActivity',s("Catalysis","of","the","reaction",":","1-alkyl-sn-glycerol","+","ATP","=","1-alkyl-sn-glycerol","3-phosphate","+","ADP","+","2","H","(","+",")"),4372710). assertion_content_comment('tOboGo_AlkylglyceroneKinaseActivity',s("Catalysis","of","the","reaction",":","O-alkylglycerone","+","ATP","=","O-alkylglycerone","phosphate","+","ADP","+","2","H","(","+",")"),4372584). assertion_content_comment('tOboGo_AlkylglycerophosphoethanolaminePhosphodiesteraseActivity',s("Catalysis","of","the","reaction",":","H2O","+","1-alkyl-sn-glycero-3-phosphoethanolamine","=","ethanolamine","+","1-alkyl-sn-glycerol","3-phosphate","."),4368534). assertion_content_comment('tOboGo_AlkylhalidaseActivity',s("Catalysis","of","the","reaction",":","bromochloromethane","+","H","(","2",")","O","=","bromide","+","chloride","+","formaldehyde","+","2","H","(","+",")"),4372661). assertion_content_comment('tOboGo_AlkylHydroperoxideReductaseActivity',s("Catalysis","of","the","reaction",":","octane","hydroperoxide","+","NADH","+","H","+","=","H2O","+","NAD","+","+","1-octanol","."),4249136). assertion_content_comment('tOboGo_AlkylHydroperoxideReductaseComplex',s("An","enzyme","complex",",","usually","a","homodimer",",","which","directly","reduces","cellular","levels","of","organic","hydroperoxides","."),4259815). assertion_content_comment('tOboGo_AlkylmercuryLyaseActivity',s("Catalysis","of","the","reaction",":","R-Hg","+","+","H","+","=","R-H","+","Hg2","+"),4273523). assertion_content_comment('tOboGo_AlkylphosphonateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","an","alkylphosphonate","from","one","side","of","a","membrane","to","the","other","."),4315921). assertion_content_comment('tOboGo_AlkylphosphonateTransport',s("The","directed","movement","of","an","alkylphosphonate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4315911). assertion_content_comment('tOboGo_AlkylSulfataseActivity',s("Catalysis","of","the","reaction",":","dodecyl","sulfate","+","H2O","=","sulfate","+","H","+","+","1-dodecanol","."),4274896). assertion_content_comment('tOboGo_AlkyneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","alkyne",",","any","cyclic","branched","or","unbranched","hydrocarbon","having","a","carbon-carbon","triple","bond","and","the","general","formula","CnH2n-2","."),4325037). 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assertion_content_comment('tOboGo_AllantoateTransport',s("The","directed","movement","of","allantoate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4228440). assertion_content_comment('tOboGo_AllantoicaseActivity',s("Catalysis","of","the","reaction",":","allantoate","+","H","(","2",")","O","=","(","S",")","-ureidoglycolate","+","urea","."),4213403). assertion_content_comment('tOboGo_AllantoinAllantoateTransport',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228457). assertion_content_comment('tOboGo_AllantoinaseActivity',s("Catalysis","of","the","reaction",":","allantoin","+","H2O","=","allantoate","."),4213427). assertion_content_comment('tOboGo_AllantoinAssimilationPathway',s("The","pathways","by","which","allantoin","is","processed","and","converted","to","ureidoglycolate",",","and","then","into","metabolically","useful","substrates",".","E",".","coli","are","able","to","utilize","allantoin","as","a","sole","nitrogen","source","under","anaerobic","conditions","by","converting","it","to","ureidoglycolate",";","this","may","be","further","metabolized","to","produce","glyoxylate","and","thence","3-phosphoglycerate",",","or","alternatively","oxidized","to","oxolureate",",","which","can","converted","into","oxamate","and","carbamoylphosphate",".","This","may","then","be","further","metabolized","to","CO2",",","NH4","+","and","ATP","."),4258804). assertion_content_comment('tOboGo_AllantoinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","allantoin",",","(","2",",","5-dioxo-4-imidazolidinyl",")","urea","."),4240840). assertion_content_comment('tOboGo_AllantoinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","allantoin",",","(","2",",","5-dioxo-4-imidazolidinyl",")","urea","."),4258799). assertion_content_comment('tOboGo_AllantoinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","allantoin",",","(","2",",","5-dioxo-4-imidazolidinyl",")","urea",",","an","intermediate","or","end","product","of","purine","catabolism","."),4240835). assertion_content_comment('tOboGo_AllantoinRacemaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-","(","+",")","-allantoin","=","(","R",")","-","(","-",")","-allantoin","."),4372690). assertion_content_comment('tOboGo_AllantoinTransport',s("The","directed","movement","of","allantoin",",","(","2",",","5-dioxo-4-imidazolidinyl",")","urea",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4228452). assertion_content_comment('tOboGo_AllantoinUptakeTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","allantoin","(","out",")","+","H","+","(","out",")","=","allantoin","(","in",")","+","H","+","(","in",")","by","secondary","active","transport","."),4215805). assertion_content_comment('tOboGo_AllatostatinReceptorActivity',s("Combining","with","allatostatin","to","initiate","a","change","in","cell","activity","."),4256199). assertion_content_comment('tOboGo_Allatostatin',s("OBSOLETE",".","Peptide","hormones","produced","by","the","corpora","allata","of","insects","that","reversibly","inhibit","the","production","of","juvenile","hormone","."),4303391). assertion_content_comment('tOboGo_AlleneOxideSynthaseActivity',s("Catalysis","of","the","reaction",":","13","(","S",")","-hydroperoxylinolenate","=","12",",","13","(","S",")","-epoxylinolenate","+","H2O","."),4261995). assertion_content_comment('tOboGo_AlliinLyaseActivity',s("Catalysis","of","the","reaction",":","an","S-alkyl-L-cysteine","S-oxide","=","an","alkyl","sulfenate","+","2-aminoacrylate","."),4372673). assertion_content_comment('tOboGo_AllophanateHydrolaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","3","H","(","+",")","+","urea-1-carboxylate","=","2","CO","(","2",")","+","2","NH","(","4",")","(","+",")"),4213415). 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assertion_content_comment('tOboGo_AlloseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","allose",",","allo-hexose",",","an","aldohexose","similar","to","glucose",",","differing","only","in","the","configuration","of","the","hydroxyl","group","of","C-3","."),4240110). assertion_content_comment('tOboGo_AlloseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","allose","from","one","side","of","the","membrane","to","the","other",".","Allose","is","an","aldohexose","similar","to","glucose",",","differing","only","in","the","configuration","of","the","hydroxyl","group","of","C-3","."),4289604). assertion_content_comment('tOboGo_AlloseTransport',s("The","directed","movement","of","allose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Allose","is","an","aldohexose","similar","to","glucose",",","differing","only","in","the","configuration","of","the","hydroxyl","group","of","C-3","."),4291072). assertion_content_comment('tOboGo_ALPBinding',s("Interacting","selectively","and","non-covalently","wih","ALP",",","actinin-associated","LIM","protein","of","the","Z","band",".","ALP","is","a","PDZ/LIM","domain","protein","found","in","the","Z","band","."),4286775). assertion_content_comment('tOboGo_AlphaDNAPolymerase_PrimaseComplex',s("A","complex","of","four","polypeptides",",","comprising","large","and","small","DNA","polymerase","alpha","subunits","and","two","primase","subunits",",","which","catalyzes","the","synthesis","of","an","RNA","primer","on","the","lagging","strand","of","replicating","DNA",";","the","smaller","of","the","two","primase","subunits","alone","can","catalyze","oligoribonucleotide","synthesis","."),4006679). assertion_content_comment('tOboGo_AlternansucraseActivity',s("Catalysis","of","the","transfer","of","an","alpha-D-glucosyl","residue","from","sucrose","to","alternately","the","6-position","and","the","3-position","of","the","non-reducing","terminal","residue","of","an","alpha-D-glucan",",","thus","producing","a","glucan","having","alternating","alpha-1",",","6-","and","alpha-1",",","3-linkages","."),4343243). assertion_content_comment('tOboGo_AlternateSplicingOfImmunoglobulinGenes',s("The","generation","of","alternate","transcripts","of","immunoglobulin","genes","through","alternate","splicing","of","exons","."),4381544). assertion_content_comment('tOboGo_AlternativeNuclearMRNASplicingViaSpliceosome',s("The","process","of","generating","multiple","mRNA","molecules","from","a","given","set","of","exons","by","differential","use","of","exons","from","the","primary","transcript","(","s",")","to","form","multiple","mature","mRNAs","that","vary","in","their","exon","composition","."),3974718). assertion_content_comment('tOboGo_AlternativeOxidaseActivity',s("Catalysis","of","the","oxidation","of","ubiquinol","by","diverting","electrons","from","the","standard","electron","transfer","chain",",","transferring","them","from","ubiquinol","to","oxygen","and","generating","water","as","the","product","."),4261890). 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assertion_content_comment('tOboGo_AlveolarSecondarySeptumDevelopment',s("The","progression","of","a","secondary","alveolar","septum","over","time",",","from","its","formation","to","the","mature","structure",".","A","secondary","alveolar","septum","is","a","specialized","epithelium","that","subdivides","the","initial","saccule","."),4135648). assertion_content_comment('tOboGo_AmbisenseViralGenome',s("A","RNA","genome","that","contains","coding","regions","that","are","either","positive","sense","or","negative","sense","on","the","same","RNA","molecule","."),4236456). assertion_content_comment('tOboGo_AmeboidalCellMigration',s("Cell","migration","that","is","accomplished","by","extension","and","retraction","of","a","pseudopodium","."),3985085). assertion_content_comment('tOboGo_Amicyanin',s("OBSOLETE",".","A","copper-containing","protein","that","acts","as","an","electron","carrier","between","methylamine","dehydrogenase","and","cytochrome","c","."),4259217). assertion_content_comment('tOboGo_AmidaseActivity',s("Catalysis","of","the","reaction",":","a","monocarboxylic","acid","amide","+","H2O","=","a","monocarboxylate","+","NH3","."),4213538). assertion_content_comment('tOboGo_AmideBinding',s("Interacting","selectively","and","non-covalently","with","an","amide",",","any","derivative","of","an","oxoacid","in","which","an","acidic","hydroxy","group","has","been","replaced","by","an","amino","or","substituted","amino","group","."),4338193). assertion_content_comment('tOboGo_AmideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","amide",",","any","derivative","of","an","oxoacid","in","which","an","acidic","hydroxy","group","has","been","replaced","by","an","amino","or","substituted","amino","group","."),4046117). assertion_content_comment('tOboGo_AmideTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","an","amide",",","any","compound","containing","one",",","two",",","or","three","acyl","groups","attached","to","a","nitrogen","atom",",","from","one","side","of","the","membrane","to","the","other","."),4291666). assertion_content_comment('tOboGo_AmideTransport',s("The","directed","movement","of","an","amide",",","any","compound","containing","one",",","two",",","or","three","acyl","groups","attached","to","a","nitrogen","atom",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4168351). assertion_content_comment('tOboGo_AmidinoaspartaseActivity',s("Catalysis","of","the","reaction",":","N-amidino-L-aspartate","+","H","(","2",")","O","=","L-aspartate","+","urea","."),4372436). assertion_content_comment('tOboGo_AmidinotransferaseActivity',s("Catalysis","of","the","reversible","transfer","of","an","amidino","group","to","an","acceptor","."),4297040). assertion_content_comment('tOboGo_AmidophosphoribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","5-phospho-beta-D-ribosylamine","+","L-glutamate","+","diphosphate","=","5-phospho-alpha-D-ribose","1-diphosphate","+","L-glutamine","+","H","(","2",")","O","."),4213479). assertion_content_comment('tOboGo_Amiloride_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","H","+","(","out",")","+","amiloride","(","in",")","=","H","+","(","in",")","+","amiloride","(","out",")"),4296566). assertion_content_comment('tOboGo_AmilorideTransporterActivity',s("Enables","the","directed","movement","of","amiloride","of","amiloride","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Amiloride","is","a","potent","and","specific","inhibitor","of","sodium","ion","entry","into","cells",".","It","is","used","as","a","potassium-sparing","diuretic","."),4295249). assertion_content_comment('tOboGo_AmilorideTransport',s("The","directed","movement","amiloride","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Amiloride","is","a","potent","and","specific","inhibitor","of","sodium","ion","entry","into","cells",".","It","is","used","as","a","potassium-sparing","diuretic","."),4294136). assertion_content_comment('tOboGo_AmineAmidePolyamineChannelActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4295359). 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assertion_content_comment('tOboGo_AmineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","organic","compound","that","is","weakly","basic","in","character","and","contains","an","amino","or","a","substituted","amino","group",",","as","carried","out","by","individual","cells",".","Amines","are","called","primary",",","secondary",",","or","tertiary","according","to","whether","one",",","two",",","or","three","carbon","atoms","are","attached","to","the","nitrogen","atom","."),3979002). assertion_content_comment('tOboGo_AmineSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","an","amine","=","adenosine","3","'",",","5","'","-bisphosphate","+","a","sulfamate","."),4372801). assertion_content_comment('tOboGo_AmineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","amines",",","including","polyamines",",","from","one","side","of","the","membrane","to","the","other",".","Amines","are","organic","compounds","that","are","weakly","basic","in","character","and","contain","an","amino","(","-NH2",")","or","substituted","amino","group","."),4158485). assertion_content_comment('tOboGo_AmineTransport',s("The","directed","movement","of","amines",",","including","polyamines",",","organic","compounds","containing","one","or","more","amino","groups",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990581). assertion_content_comment('tOboGo_Aminoacetone_OxygenOxidoreductaseDeaminatingActivity',s("Catalysis","of","the","reaction",":","aminoacetone","+","H2O","+","O2","=","methylglyoxal","+","NH3","+","hydrogen","peroxide","+","H","+"),4186670). assertion_content_comment('tOboGo_AminoAcidActivationForNonribosomalPeptideBiosyntheticProcess',s("Activation","of","an","amino","acid","for","incorporation","into","a","peptide","by","a","nonribosomal","process","."),4094127). assertion_content_comment('tOboGo_AminoAcidActivation',s("The","modification","of","an","amino","acid","to","an","active","form",",","for","incorporation","into","a","peptide",",","protein","or","other","macromolecule","."),4009672). assertion_content_comment('tOboGo_AminoAcidAdenylylationByNonribosomalPeptideSynthase',s("Activation","of","an","amino","acid","for","incorporation","into","a","peptide","by","a","nonribosomal","process",",","catalyzed","by","subunits","of","nonribosomal","peptide","synthase",".","The","amino","acid","is","adenylated","at","its","carboxylate","group","(","ATP-dependent",")","then","transferred","to","the","thiol","group","of","an","enzyme-bound","phosphopantetheine","cofactor","."),4317941). assertion_content_comment('tOboGo_AminoAcidBinding',s("Interacting","selectively","and","non-covalently","with","an","amino","acid",",","organic","acids","containing","one","or","more","amino","substituents","."),4157080). 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assertion_content_comment('tOboGo_AminoAcidImport',s("The","directed","movement","of","amino","acids","into","a","cell","or","organelle","."),4025874). assertion_content_comment('tOboGo_AminoAcidKinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","an","amino","acid","substrate","."),4206327). assertion_content_comment('tOboGo_AminoAcidSalvage',s("Any","process","which","produces","an","amino","acid","from","derivatives","of","it",",","without","de","novo","synthesis","."),4240888). assertion_content_comment('tOboGo_AminoAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","amino","acids","from","one","side","of","a","membrane","to","the","other",".","Amino","acids","are","organic","molecules","that","contain","an","amino","group","and","a","carboxyl","group","."),4158511). 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assertion_content_comment('tOboGo_AminoacylaseActivity',s("Catalysis","of","the","reaction",":","an","N-acyl-L-amino","acid","+","H2O","=","a","carboxylate","+","an","L-amino","acid","."),4213438). assertion_content_comment('tOboGo_AminobenzoateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","4","(","or","2",")","-aminobenzoate","=","aniline","+","CO2","."),4372561). assertion_content_comment('tOboGo_AminobutyraldehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","4-aminobutanal","+","NAD","+","+","H2O","=","4-aminobutanoate","+","NADH","+","2","H","+"),4237421). assertion_content_comment('tOboGo_AminodeoxychorismateSynthaseComplex',s("A","heterodimeric","protein","complex","that","possesses","4-amino-4-deoxychorismate","synthase","activity","."),4260190). 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assertion_content_comment('tOboGo_AminoglycosideAntibioticMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","an","aminoglycoside","antibiotic",",","any","member","of","a","group","of","broad","spectrum","antibiotics",",","of","similar","toxicity","and","pharmacology",",","that","contain","an","aminodeoxysugar",",","an","amino-","or","guanidino-substituted","inositol","ring",",","and","one","or","more","residues","of","other","sugars",".","The","group","includes","streptomycin",",","neomycin",",","framycetin",",","kanamycin",",","paromomycin",",","and","gentamicin","."),4234081). assertion_content_comment('tOboGo_AminoglycosideNucleotidyltransferaseActivity',s("Catalysis","of","the","reaction",":","nucleoside","triphosphate","+","aminoglycoside","=","diphosphate","+","nucleotidylaminoglycoside","."),4249729). assertion_content_comment('tOboGo_AminoglycosidePhosphotransferaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","aminoglycoside","=","ADP","+","phosphoaminoglycoside","."),4248352). assertion_content_comment('tOboGo_AminohydroquinoneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","aminohydroquinone","+","2","e-","+","2","H","+","+","1/2","O2","=","1",",","2",",","4-benzenetriol","+","NH3","."),4348705). assertion_content_comment('tOboGo_AminoimidazolaseActivity',s("Catalysis","of","the","reaction",":","4-aminoimidazole","+","H2O","=","unidentified","product","+","NH3","."),4372533). assertion_content_comment('tOboGo_AminolevulinateTransaminaseActivity',s("Catalysis","of","the","reaction",":","5-aminolevulinate","+","pyruvate","=","4",",","5-dioxopentanoate","+","L-alanine","."),4372506). assertion_content_comment('tOboGo_AminomethyltransferaseActivity',s("Catalysis","of","the","reaction",":","(","6S",")","-tetrahydrofolate","+","S-aminomethyldihydrolipoylprotein","=","(","6R",")","-5",",","10-methylenetetrahydrofolate","+","NH3","+","dihydrolipoylprotein","."),4213586). assertion_content_comment('tOboGo_AminopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","N-terminal","amino","acid","residues","from","in","a","polypeptide","chain","."),4180810). assertion_content_comment('tOboGo_AminopeptidaseBActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","N-terminal","Arg","and","Lys","from","oligopeptides","when","P1","'","is","not","Pro",".","Also","acts","on","arylamides","of","Arg","and","Lys","."),4308343). 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assertion_content_comment('tOboGo_AminophospholipidTransport',s("The","directed","movement","of","aminophospholipids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Aminophospholipids","contain","phosphoric","acid","as","a","mono-","or","diester","and","an","amino","(","NH2",")","group","."),4294458). assertion_content_comment('tOboGo_AminophosphonateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","aminophosphonates",",","phosphonic","acid","derivatives","that","contain","an","amino","group","."),4244084). assertion_content_comment('tOboGo_AminopropylagmatineUreohydrolaseActivity',s("Catalysis","of","the","reaction",":","N1-aminopropylagmatine","+","H2O","=","spermidine","+","urea","."),4328069). 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assertion_content_comment('tOboGo_AminotriazoleTransport',s("The","directed","movement","of","aminotriazole","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Aminotriazole","is","an","effective","weed","killer","that","also","possesses","some","antithyroid","activity","."),4294126). assertion_content_comment('tOboGo_Amitosis',s("Nuclear","division","that","occurs","by","simple","constriction","of","the","nucleus","without","chromosome","condensation","or","spindle","formation","."),4286228). assertion_content_comment('tOboGo_AmmelideAminohydrolaseActivity',s("Catalysis","of","the","reaction",":","ammelide","+","H2O","=","cyanuric","acid","+","NH3","."),4274793). assertion_content_comment('tOboGo_AmmelineAminohydrolaseActivity',s("Catalysis","of","the","reaction",":","ammeline","+","H2O","=","ammelide","+","NH3","."),4274811). 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assertion_content_comment('tOboGo_AmmoniaAssimilationCycle',s("The","pathway","by","which","ammonia","is","processed","and","incorporated","into","a","cell",".","In","an","energy-rich","(","glucose-containing",")",",","nitrogen-poor","environment",",","glutamine","synthetase","and","glutamate","synthase","form","an","ammonia","assimilatory","cycle",",","in","which","ammonia","is","incorporated","into","L-glutamate","to","form","L-glutamine",",","which","then","combines","with","alpha-ketoglutarate","to","regenerate","L-glutamate",".","This","ATP-dependent","cycle","is","essential","for","nitrogen-limited","growth","and","for","steady-state","growth","with","some","sources","of","nitrogen","."),4244763). assertion_content_comment('tOboGo_AmmoniaKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","NH","(","4",")","(","+",")","=","ADP","+","3","H","(","+",")","+","phosphoramidate","."),4372494). 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assertion_content_comment('tOboGo_AmnioserosaMaintenance',s("Maintenance","of","the","amnioserosa",",","an","epithelium","that","occupies","a","hole","in","the","embryonic","dorsal","epidermis","."),4099054). assertion_content_comment('tOboGo_AMPBinding',s("Interacting","selectively","and","non-covalently","with","AMP",",","adenosine","monophosphate","."),4303890). assertion_content_comment('tOboGo_AMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","AMP",",","adenosine","monophosphate","."),4227633). assertion_content_comment('tOboGo_AMPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","AMP",",","adenosine","monophosphate","."),4227341). assertion_content_comment('tOboGo_AMPDeaminaseActivity',s("Catalysis","of","the","reaction",":","AMP","+","H2O","=","IMP","+","NH3","."),4189722). 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assertion_content_comment('tOboGo_AnaerobicBenzoateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","benzoate",",","the","anion","of","benzoic","acid","(","benzenecarboxylic","acid",")","that","occur","in","the","absence","of","oxygen","."),4273135). assertion_content_comment('tOboGo_AnaerobicCarbonTetrachlorideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carbon","tetrachloride",",","a","toxic",",","carcinogenic","compound","which","is","used","as","a","general","solvent","in","industrial","degreasing","operations",",","that","occur","in","the","absence","of","oxygen","."),4273415). 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assertion_content_comment('tOboGo_AnaerobicGlutamateCatabolicProcess',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glutamate",",","yielding","energy","in","the","form","of","ATP","."),4243026). assertion_content_comment('tOboGo_AnaerobicGlycerolCatabolicProcess',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycerol",",","yielding","energy","in","the","form","of","ATP","."),4243182). assertion_content_comment('tOboGo_AnaerobicGlycineCatabolicProcess',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycine",",","yielding","energy","in","the","form","of","ATP","."),4244444). assertion_content_comment('tOboGo_AnaerobicNitrilotriacetateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","nitrilotriacetate",",","the","aminotricarboxylic","acid","N","(","CH2COO-",")","3",",","that","occur","in","the","absence","of","oxygen","."),4272202). assertion_content_comment('tOboGo_AnaerobicOrganosiliconMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","organosilicons",",","organic","compounds","that","contain","silicon",",","in","the","absence","of","oxygen","."),4272679). assertion_content_comment('tOboGo_AnaerobicPhenylalanineOxidation',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenylalanine","under","anaerobic","conditions",";","occurs","via","the","intermediates","phenylpyruvate","and","phenylacetaldehyde","."),4242875). assertion_content_comment('tOboGo_AnaerobicPurineBaseCatabolicProcess',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","purine","bases",",","yielding","energy","in","the","form","of","ATP","."),4244291). assertion_content_comment('tOboGo_AnaerobicRespiration',s("The","enzymatic","release","of","energy","from","organic","compounds","(","especially","carbohydrates","and","fats",")","which","uses","compounds","other","than","oxygen","(","e.g",".","nitrate",",","sulfate",")","as","the","terminal","electron","acceptor","."),4042432). assertion_content_comment('tOboGo_AnaerobicRespirationUsingAmmoniumAsElectronDonor',s("The","oxidation","of","ammonium","(","NH4",")","to","nitrogen","(","N2",")","in","the","absence","of","oxygen",",","using","nitrite","(","NO2",")","as","the","electron","acceptor",".","It","is","suggested","that","hydroxylamine","and","ammonium","are","combined","to","yield","hydrazine",",","which","is","subsequently","oxidized","to","N2","."),4240512). assertion_content_comment('tOboGo_AnaerobicRhamnoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","rhamnose",",","the","hexose","6-deoxy-L-mannose",",","that","occurs","in","the","absence","of","oxygen","."),4239161). 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assertion_content_comment('tOboGo_Anagen',s("The","growth","phase","of","the","hair","cycle",".","Lasts",",","for","example",",","about","3","to","6","years","for","human","scalp","hair","."),4077905). assertion_content_comment('tOboGo_AnalFinDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anal","fin","over","time",",","from","its","formation","to","the","mature","structure","."),4071886). assertion_content_comment('tOboGo_AnalFinMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","anal","fin","are","generated","and","organized",".","An","anal","fin","is","an","unpaired","medial","fin","on","the","ventral","aspect","near","the","caudal","end","of","a","fish",",","which","provides","lateral","stability","while","swimming","."),4071896). 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assertion_content_comment('tOboGo_Anammoxosome',s("An","intracytoplasmic","membrane-bounded","compartment","in","anaerobic","ammonium","oxidation","(","anammox",")","bacteria",",","is","the","site","of","anammox","catabolism","."),4288033). assertion_content_comment('tOboGo_Anaphase',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","anaphase",",","the","third","stage","of","chromosome","segregation","in","the","cell","cycle",".","Canonically",",","sister","chromatids","(","or","homologous","chromosomes",")","separate","and","migrate","towards","the","poles","of","the","spindle","."),3971199). assertion_content_comment('tOboGo_AnaphylatoxinReceptorActivity',s("Combining","with","anaphylatoxin","to","initiate","a","change","in","cell","activity","."),4197916). 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assertion_content_comment('tOboGo_AnhydrosialidaseActivity',s("Catalysis","of","the","elimination","of","alpha-sialyl","groups","in","N-acetylneuraminic","acid","glycosides",",","releasing","2",",","7-anhydro-alpha-N-acetylneuraminate","."),4345263). assertion_content_comment('tOboGo_AnhydrotetracyclineMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","anhydrotetracycline","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","12-dehydrotetracycline","+","H","(","2",")","O","+","NADP","(","+",")"),4372859). assertion_content_comment('tOboGo_Anion_AnionAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","anion","A","(","out",")","+","anion","B","(","in",")","=","anion","A","(","in",")","+","anion","B","(","out",")"),4020537). 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assertion_content_comment('tOboGo_AnnularFurrowExtracellularMatrix',s("The","extracellular","matrix","part","that","is","a","regularly","spaced","indentation","in","the","outer","cortical","layer","of","the","cuticle",".","The","pattern","of","annular","furrows","corresponds","to","sites","of","invaginations","in","hypodermal","cell","membranes","that",",","in","turn",",","correspond","to","submembranous","regions","where","actin","microfilament","bundles","assemble","early","in","lethargus",",","the","first","phase","of","the","molting","cycle","in","which","activity","and","feeding","decline","."),4108926). assertion_content_comment('tOboGo_AnnulateLamellae',s("Stacks","of","endoplasmic","reticulum","(","ER",")","membranes","containing","a","high","density","of","nuclear","pores",",","thought","to","form","from","excess","nuclear","membrane","components",",","that","have","been","described","in","a","number","of","different","cells",".","Annulate","lamellar","membranes","are","continuous","with","and","embedded","within","the","ER","."),4006585). assertion_content_comment('tOboGo_AnnuliExtracellularMatrix',s("The","extracellular","matrix","that","is","a","regularly","spaced","circumferential","ridge","present","in","the","cortical","region","of","the","cuticle",".","Annuli","are","delineated","by","annular","furrows","and","are","present","throughout","the","cuticle","with","the","exception","of","lateral","regions","where","longitudinal","alae","are","present","."),4108912). assertion_content_comment('tOboGo_Anoikis',s("Apoptosis","triggered","by","inadequate","or","inappropriate","adherence","to","substrate","e.g",".","after","disruption","of","the","interactions","between","normal","epithelial","cells","and","the","extracellular","matrix","."),4141087). assertion_content_comment('tOboGo_AnsamycinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","leading","to","the","formation","of","ansamycins",",","any","of","a","group","of","complex","macrolactam","compounds","characterized","by","a","cyclic","structure","in","which","an","aliphatic","ansa","chain","forms","a","bridge","between","two","non-adjacent","positions","of","a","cyclic","p-system",";","many","exhibit","antibacterial",",","antifungal","or","antitumor","activity","."),4347431). assertion_content_comment('tOboGo_AnsamycinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ansamycins",",","any","of","a","group","of","complex","macrolactam","compounds","characterized","by","a","cyclic","structure","in","which","an","aliphatic","ansa","chain","forms","a","bridge","between","two","non-adjacent","positions","of","a","cyclic","p-system",";","many","exhibit","antibacterial",",","antifungal","or","antitumor","activity","."),4347349). assertion_content_comment('tOboGo_AntennalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","antenna","over","time",",","from","its","formation","to","the","mature","structure",".","The","antenna","are","the","sensory","structures","on","the","head","that","are","capable","of","detecting","various","environmental","stimuli","."),4017929). assertion_content_comment('tOboGo_AntennalJointDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","antennal","joint","over","time",",","from","its","formation","to","the","mature","structure",".","The","antennal","joint","is","the","joint","between","antennal","segments","."),4104401). assertion_content_comment('tOboGo_AntennalJointMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","antennal","joint","are","generated","and","organized","."),4105361). assertion_content_comment('tOboGo_AntennalMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","antenna","are","generated","and","organized","."),4072501). assertion_content_comment('tOboGo_AnteriorCibarialPlateDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anterior","cibarial","plate","over","time",",","from","their","formation","to","the","mature","structure","."),4107324). assertion_content_comment('tOboGo_AnteriorCibarialPlateMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","anterior","cibarial","plate","are","generated","and","organized","."),4107394). assertion_content_comment('tOboGo_AnteriorCommissureMorphogenesis',s("Generation","of","a","long","process","of","a","CNS","neuron",",","that","carries","efferent","(","outgoing",")","action","potentials","from","the","cell","body","in","one","half","of","the","cerebral","cortex","towards","target","cells","in","the","contralateral","half",".","This","axonal","process","is","a","member","of","those","that","make","up","the","anterior","commissure",",","a","small","midline","fiber","tract","that","lies","at","the","anterior","end","of","the","corpus","callosum","."),4047752). assertion_content_comment('tOboGo_AnteriorCompartmentPatternFormation',s("The","process","giving","rise","to","specification","of","cell","identity","in","the","anterior","compartments","of","the","segmented","embryo","."),4234561). assertion_content_comment('tOboGo_AnteriorHeadSegmentation',s("Partitioning","the","head","anlage","into","procephalic","(","labral",",","(","ocular",")",",","antennal","and","intercalary",")","segments",".","The","procephalic","segments","lie","anterior","to","the","gnathal","(","posterior","head",")","segments",",","and","are","pattered","by","different","segmentation","gene","cascades","to","the","abdominal",",","thoracic","and","posterior","head","(","gnathal",")","segments","."),4019513). assertion_content_comment('tOboGo_AnteriorLateralLineDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anterior","lateral","line","over","time",",","from","its","formation","to","the","mature","structure",".","The","anterior","lateral","line","consists","of","small","sensory","patches","(","neuromasts",")","located","superficially","on","the","skin","or","just","under","the","skin","in","fluid-filled","canals","on","the","head","of","all","fishes","and","most","amphibians",".","The","anterior","lateral","line","develops","from","cranial","ectodermal","placodes","situated","between","the","eye","and","ear","."),4082679). assertion_content_comment('tOboGo_AnteriorLateralLineGanglionDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anterior","lateral","line","ganglion","over","time",",","from","its","formation","to","the","mature","structure",".","The","anterior","lateral","line","ganglion","develops","from","cranial","ectodermal","placodes","situated","between","the","eye","and","ear","."),4105784). assertion_content_comment('tOboGo_AnteriorLateralLineGanglionNeuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuron","of","the","anterior","lateral","line","ganglion","."),4106198). assertion_content_comment('tOboGo_AnteriorLateralLineNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anterior","lateral","line","nerve","over","time",",","form","its","formation","to","the","mature","structure",".","The","anterior","lateral","line","nerve","contains","efferent","axons","that","innervate","hair","cells","of","the","ALL","and","afferent","axons","that","project","to","an","octavolateralis","column","in","the","hindbrain",".","The","octavolateralis","column","consists","of","the","medial","octavolateralis","nucleus","(","MON",")",",","the","caudal","octavolateralis","nucleus",",","and","the","magnocellular","nucleus","."),4105967). assertion_content_comment('tOboGo_AnteriorLateralLineNerveGlialCellDevelopment',s("The","process","aimed","at","the","progression","of","a","glial","cell","in","the","anterior","lateral","line","nerve","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4105982). assertion_content_comment('tOboGo_AnteriorLateralLineNerveGlialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","glial","cell","in","the","anterior","lateral","line","nerve","."),4105972). assertion_content_comment('tOboGo_AnteriorLateralLineNerveGlialCellMorphogenesisInvolvedInDifferentiation',s("The","process","in","which","the","structures","of","a","glial","cell","in","the","anterior","lateral","line","nerve","are","generated","and","organized",".","This","process","occurs","while","the","initially","relatively","unspecialized","cell","is","acquiring","the","specialized","features","of","a","glial","cell","in","the","anterior","lateral","line","nerve","."),4106026). assertion_content_comment('tOboGo_AnteriorLateralLineNeuromastCupulaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anterior","lateral","line","neuromast","cupula","over","time",",","from","its","formation","to","the","mature","structure",".","The","cupula","is","secreted","by","mantle","cells","and","the","ciliary","bundles","of","all","of","the","hair","cells","of","the","neuromast","are","embedded","in","it",".","The","cupula","provides","a","mechanical","linkage","between","the","hair","cells","and","the","external","hydrodynamic","environment",".","The","cupula","of","superficial","neuromasts","grows","continuously",",","while","the","height","of","the","cupula","of","canal","neuromasts","is","limited","by","canal","diameter","."),4105805). 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assertion_content_comment('tOboGo_AnteriorLateralLineNeuromastPrimordiumMigration',s("The","migration","of","a","cluster","of","a","relatively","undifferentiated","cell","along","the","developing","anterior","lateral","line",",","originating","from","cranial","ectodermal","placodes","situated","between","the","eye","and","the","ear",".","The","neuromast","primordium","deposits","proneuromasts","along","the","lateral","line",",","from","which","the","neuromasts","will","develop","."),4105742). assertion_content_comment('tOboGo_AnteriorLateralLineNeuromastSupportCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","anterior","lateral","line","neuromast","support","cell",".","Support","cells","are","non-sensory","cells","of","the","neuromast","that","extend","between","the","sensory","hair","cells","from","the","basement","membrane","to","the","apical","surface",";","they","are","surrounded","by","mantle","cells","."),4105762). assertion_content_comment('tOboGo_AnteriorLateralLineSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anterior","lateral","line","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","anterior","lateral","line","system","develops","from","cranial","ectodermal","placodes",",","situated","between","the","eye","and","the","ear",",","that","give","rise","to","both","the","neuromasts","and","the","anterior","lateral","line","sensory","nerves","that","innervate","the","neuromasts",".","The","anterior","lateral","line","system","consists","of","small","sensory","patches","(","neuromasts",")","located","superficially","on","the","skin","or","just","under","the","skin","in","fluid-filled","canals","on","the","head","of","all","fishes","and","most","amphibians","and","are","innervated","by","several","lateral","line","nerves",",","which","project","to","the","hindbrain",".","The","anterior","lateral","line","system","is","stimulated","by","local","water","displacements","and","vibrations",",","and","detects","propulsion","of","the","fish","through","the","water",",","as","well","as","facilitating","shoaling",",","prey","capture",",","and","predator","and","obstacle","avoidance","."),4082676). assertion_content_comment('tOboGo_AnteriorMalpighianTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anterior","Malpighian","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","pair","of","anterior","tubules","arise","from","a","dorsal","region","of","the","embryonic","hindgut","and","projects","forwards","through","the","body","cavity",".","A","Malpighian","tubule","is","a","fine",",","thin-walled","excretory","tubule","in","insects","which","connects","with","the","posterior","part","of","the","gut","."),4261611). assertion_content_comment('tOboGo_AnteriorMesonephricTubuleDevelopment',s("The","progression","of","the","anterior","mesonephric","tubule","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","anterior","mesonephric","tubule","is","an","epithelial","tube","that","is","part","of","the","mesonephros","."),4123299). assertion_content_comment('tOboGo_AnteriorMidgutDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anterior","midgut","over","time",",","from","its","formation","to","the","mature","structure","."),4018293). assertion_content_comment('tOboGo_AnteriorMidgutEctodermalMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","anterior","midgut","(","ectodermal",")","are","generated","and","organized","."),4017666). assertion_content_comment('tOboGo_AnteriorMidgutInvagination',s("Internalization","of","the","anterior","midgut","into","the","interior","of","the","embryo","."),4019577). assertion_content_comment('tOboGo_AnteriorMRNALocalizationInvolvedInAnteriorPosteriorAxisSpecification',s("Any","process","in","which","a","mRNA","is","transported","to",",","and","maintained","in","the","anterior","portion","of","the","oocyte","and/or","syncytial","embryo","contributing","to","the","specification","of","the","anterior/posterior","axis","."),4156324). assertion_content_comment('tOboGo_AnteriorNeuralPlateFormation',s("The","formation","of","anterior","end","of","the","flat",",","thickened","layer","of","ectodermal","cells","known","as","the","neural","plate","."),4149649). assertion_content_comment('tOboGo_AnteriorNeuroporeClosure',s("The","joining","together","of","the","neural","folds","of","the","rostral","opening","of","the","neural","tube",".","The","anterior","neuropore","appears","before","the","process","of","neural","tube","closure","is","complete","."),4041653). assertion_content_comment('tOboGo_AnteriorPosteriorAxisSpecificationEmbryo',s("The","specification","of","the","anterior/posterior","axis","of","the","embryo","by","the","products","of","genes","expressed","maternally","and","genes","expressed","in","the","zygote","."),4018949). assertion_content_comment('tOboGo_AnteriorPosteriorAxisSpecificationFollicularEpithelium',s("Polarization","of","the","follicle","cells","of","an","insect","ovary","along","the","anterior/posterior","axis","."),4052133). assertion_content_comment('tOboGo_AnteriorPosteriorAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","anterior/posterior","axis",".","The","anterior-posterior","axis","is","defined","by","a","line","that","runs","from","the","head","or","mouth","of","an","organism","to","the","tail","or","opposite","end","of","the","organism","."),4018898). assertion_content_comment('tOboGo_AnteriorPosteriorAxonGuidance',s("The","process","in","which","the","migration","of","an","axon","growth","cone","is","directed","to","a","specific","target","site","along","the","anterior-posterior","body","axis","in","response","to","a","combination","of","attractive","and","repulsive","cues",".","The","anterior-posterior","axis","is","defined","by","a","line","that","runs","from","the","head","or","mouth","of","an","organism","to","the","tail","or","opposite","end","of","the","organism","."),4341146). assertion_content_comment('tOboGo_AnteriorPosteriorLineageRestrictionImaginalDisc',s("Formation","and/or","maintenance","of","a","lineage","boundary","between","anterior","and","posterior","compartments","that","cells","cannot","cross",",","thus","separating","the","populations","of","cells","in","each","compartment","."),4072303). assertion_content_comment('tOboGo_AnteriorPosteriorPatternFormationImaginalDisc',s("The","establishment",",","maintenance","and","elaboration","of","the","anterior/posterior","axis","of","the","imaginal","disc",".","Imaginal","discs","are","epithelial","infoldings","in","the","larvae","of","holometabolous","insects","that","rapidly","develop","into","adult","appendages","during","metamorphosis","from","larval","to","adult","form","."),4072283). assertion_content_comment('tOboGo_AnteriorPosteriorPatternFormation',s("The","regionalization","process","in","which","specific","areas","of","cell","differentiation","are","determined","along","the","anterior-posterior","axis",".","The","anterior-posterior","axis","is","defined","by","a","line","that","runs","from","the","head","or","mouth","of","an","organism","to","the","tail","or","opposite","end","of","the","organism","."),3985127). assertion_content_comment('tOboGo_AnteriorPosteriorPatternSpecificationInvolvedInKidneyDevelopment',s("The","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","kidney","along","the","anterior/posterior","axis","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4073470). assertion_content_comment('tOboGo_AnteriorPosteriorPatternSpecificationInvolvedInPronephrosDevelopment',s("The","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","pronephros","along","the","anterior/posterior","axis","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4073475). assertion_content_comment('tOboGo_AnteriorPosteriorPatternSpecificationInvolvedInUretericBudDevelopment',s("The","developmental","process","that","results","in","the","creation","of","defined","areas","or","spaces","within","the","ureteric","bud","along","the","anterior/posterior","axis","to","which","cells","respond","and","eventually","are","instructed","to","differentiate","."),4124024). assertion_content_comment('tOboGo_AnteriorRegionDetermination',s("Specification","of","the","anterior","(","head","and","thoracic","segments",")","of","the","embryo","by","the","gap","genes",";","exemplified","in","insects","by","the","actions","of","hunchback","gene","product","."),4019290). assertion_content_comment('tOboGo_AnteriorRotationOfTheOpticCup',s("A","90","degree-rotation","of","the","optic","cup","resulting","in","its","alignment","with","the","anterior-posterior","body","axis","."),4004557). assertion_content_comment('tOboGo_AnteriorSemicircularCanalDevelopment',s("The","progession","of","the","anterior","semicircular","canal","from","its","initial","formation","to","the","mature","structure","."),4156431). assertion_content_comment('tOboGo_AnterogradeAxonCargoTransport',s("The","directed","movement","of","organelles","or","molecules","along","microtubules","from","the","cell","body","toward","the","cell","periphery","in","nerve","cell","axons","."),4247185). assertion_content_comment('tOboGo_AnterogradeSynapticVesicleTransport',s("The","directed","movement","of","substances","in","synaptic","membrane-bounded","vesicles","within","the","neuron",",","along","the","cytoskeleton",",","away","from","the","neuronal","cell","body","."),4335736). assertion_content_comment('tOboGo_AntheraxanthinEpoxidaseActivity',s("Catalysis","of","the","reaction",":","antheraxanthin","+","NAD","(","P",")","H","+","H","+","+","O2","=","all-trans-violaxanthin","+","NAD","(","P",")","+","+","H2O","."),4191987). assertion_content_comment('tOboGo_AntherDehiscence',s("The","dehiscence","of","an","anther","to","release","the","pollen","grains","contained","within","it","."),4021444). assertion_content_comment('tOboGo_AntherDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anther","over","time",",","from","its","formation","to","the","mature","structure","."),4021425). assertion_content_comment('tOboGo_AntherMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","anther","are","generated","and","organized","."),4032053). assertion_content_comment('tOboGo_AntherSeptumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","anther","septum","over","time",",","from","its","formation","to","the","mature","structure",".","The","anther","septum","is","a","thin","partition","or","stretch","of","cells","that","are","present","in","the","anther","dehiscence","zone","."),4147516). assertion_content_comment('tOboGo_AnthocyanidinReductaseActivity',s("Catalysis","of","the","reaction",":","a","flavan-3-ol","+","2","NAD","(","P",")","+","=","an","anthocyanidin","+","2","NAD","(","P",")","H","+","H","+"),4342530). assertion_content_comment('tOboGo_AnthocyaninAccumulationInTissuesInResponseToUVLight',s("The","aggregation","of","the","pigment","anthocyanin","in","a","particular","location","in","a","tissue",",","occurring","in","response","to","a","UV","light","stimulus","."),4096088). assertion_content_comment('tOboGo_AnthocyaninBiosyntheticProcessInvolvedInAnthocyaninAccumulationInResponseToUVLight',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","pigment","anthocyanin",",","contributing","to","anthocyanin","accumulation","in","a","tissue","in","response","to","a","UV","light","stimulus","."),4096110). assertion_content_comment('tOboGo_AnthocyaninBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","anthocyanins",",","any","member","of","a","group","of","intensely","colored","soluble","glycosides","of","anthocyanidins","."),4060547). assertion_content_comment('tOboGo_AnthocyaninCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","anthocyanins",",","any","member","of","a","group","of","intensely","colored","soluble","glycosides","of","anthocyanidins","."),4352989). assertion_content_comment('tOboGo_AnthocyaninMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","anthocyanins",",","any","member","of","a","group","of","intensely","colored","soluble","glycosides","of","anthocyanidins","that","occur","in","plants",".","They","are","responsible","from","most","of","the","scarlet",",","purple",",","mauve","and","blue","coloring","in","higher","plants",",","especially","of","flowers","."),4060544). assertion_content_comment('tOboGo_AnthranilateAdenylyltransferaseActivity',s("Catalysis","of","the","reaction",":","anthranilate","+","ATP","=","N-adenylylanthranilate","+","diphosphate","+","H","(","+",")"),4372881). assertion_content_comment('tOboGo_AnthranilateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","anthranilate","(","2-aminobenzoate",")"),4324724). assertion_content_comment('tOboGo_AnthranilateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","anthranilate","(","2-aminobenzoate",")"),4273192). assertion_content_comment('tOboGo_AnthranilatePhosphoribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","N-","(","5-phospho-beta-D-ribosyl",")","anthranilate","+","diphosphate","=","5-phospho-alpha-D-ribose","1-diphosphate","+","anthranilate","."),4213567). assertion_content_comment('tOboGo_AnthranilateSynthaseActivity',s("Catalysis","of","the","reaction",":","chorismate","+","L-glutamine","=","anthranilate","+","pyruvate","+","L-glutamate","."),4213555). assertion_content_comment('tOboGo_AnthranilateSynthaseComplex',s("A","heterotetrameric","enzyme","complex","made","up","of","two","components","I","and","two","components","II",".","Catalyzes","the","formation","of","anthranilate",",","pyruvate","and","L-glutamate","from","chorismate","and","L-glutamine","."),4221151). 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assertion_content_comment('tOboGo_AntibacterialPeptideSecretion',s("The","regulated","release","of","an","antibacterial","peptide","from","a","cell","or","group","of","cells","."),3997396). assertion_content_comment('tOboGo_AntibioticBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","antibiotic",",","a","substance","produced","by","or","derived","from","certain","fungi",",","bacteria",",","and","other","organisms",",","that","can","destroy","or","inhibit","the","growth","of","other","microorganisms","."),4234064). assertion_content_comment('tOboGo_AntibioticCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","antibiotic",",","a","substance","produced","by","or","derived","from","certain","fungi",",","bacteria",",","and","other","organisms",",","that","can","destroy","or","inhibit","the","growth","of","other","microorganisms","."),4066609). 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assertion_content_comment('tOboGo_AntibioticTransport',s("The","directed","movement","of","an","antibiotic",",","a","substance","produced","by","or","derived","from","certain","fungi",",","bacteria",",","and","other","organisms",",","that","can","destroy","or","inhibit","the","growth","of","other","microorganisms",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4294193). assertion_content_comment('tOboGo_AnticoagulantActivity',s("OBSOLETE",".","Functions","to","retard","or","prevent","coagulation",".","Often","used","in","the","context","of","blood","or","milk","coagulation","."),4253613). assertion_content_comment('tOboGo_AntifreezeActivity',s("OBSOLETE",".","Inhibits","the","formation","of","ice","crystals","in","organismal","fluid","(","e.g",".","blood",")","at","below","freezing","exogenous","temperatures","."),4304053). assertion_content_comment('tOboGo_AntifungalHumoralResponse',s("An","immune","response","against","a","fungus","mediated","through","a","body","fluid",".","An","example","of","this","process","is","the","antifungal","humoral","response","in","Drosophila","melanogaster","."),3997483). assertion_content_comment('tOboGo_AntifungalPeptideActivity',s("OBSOLETE",".","Inhibits","the","growth","of",",","or","directly","kills",",","fungal","cells","."),4193005). assertion_content_comment('tOboGo_AntifungalPeptideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","antifungal","peptide","."),3997756). assertion_content_comment('tOboGo_AntifungalPeptideProduction',s("The","synthesis","or","release","of","an","antifungal","peptide","during","an","immune","response",",","resulting","in","an","increase","in","intracellular","or","extracellular","levels","."),3997485). assertion_content_comment('tOboGo_AntifungalPeptideSecretion',s("The","regulated","release","of","an","antifungal","peptide","from","a","cell","or","group","of","cells","."),3997662). assertion_content_comment('tOboGo_AntigenBinding',s("Interacting","selectively","and","non-covalently","with","an","antigen",",","any","substance","which","is","capable","of","inducing","a","specific","immune","response","and","of","reacting","with","the","products","of","that","response",",","the","specific","antibody","or","specifically","sensitized","T-lymphocytes",",","or","both",".","Binding","may","counteract","the","biological","activity","of","the","antigen","."),4052519). assertion_content_comment('tOboGo_AntigenicVariation',s("Any","process","involved","in","the","biological","strategy","of","changing","antigenic","determinants","on","the","surface","that","are","exposed","to","another","organism","'","s","immune","system","."),4079975). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationEndogenousLipidAntigenViaMHCClassIb',s("The","process","in","which","an","antigen-presenting","cell","expresses","lipid","antigen","of","endogenous","origin","in","association","with","an","MHC","class","Ib","protein","complex","on","its","cell","surface",".","Class","Ib","here","refers","to","non-classical","class","I","molecules",",","such","as","those","of","the","CD1","family","."),4384666). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationExogenousLipidAntigenViaMHCClassIb',s("The","process","in","which","an","antigen-presenting","cell","expresses","lipid","antigen","of","exogenous","origin","in","association","with","an","MHC","class","Ib","protein","complex","on","its","cell","surface",".","Class","Ib","here","refers","to","non-classical","class","I","molecules",",","such","as","those","of","the","CD1","family","."),4384678). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationFollowingMacropinocytosis',s("Antigen","processing","and","presentation","which","is","initiated","by","uptake","of","antigen","via","macropinocytosis","."),4382496). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationFollowingPhagocytosis',s("Antigen","processing","and","presentation","which","is","initiated","by","uptake","of","antigen","via","phagocytosis","."),4382519). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationFollowingPinocytosis',s("Antigen","processing","and","presentation","which","is","initiated","by","uptake","of","antigen","via","pinocytosis","."),4381435). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationFollowingReceptorMediatedEndocytosis',s("Antigen","processing","and","presentation","which","is","initiated","by","uptake","of","antigen","receptor-mediated","endocytosis","."),4381466). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationInitiatedByPatternRecognitionReceptorMediatedUptakeOfAntigen',s("Antigen","processing","and","presentation","which","is","initiated","by","uptake","of","antigen","bound","to","a","cell","surface","pattern","recognition","receptor","(","PRR",")"),4382536). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationInitiatedByReceptorMediatedUptakeOfAntigen',s("Antigen","processing","and","presentation","which","is","initiated","by","uptake","of","antigen","bound","to","a","cell","surface","receptor","."),4381464). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationOfEndogenousAntigen',s("The","process","in","which","an","antigen-presenting","cell","expresses","antigen","(","peptide","or","lipid",")","of","endogenous","origin","on","its","cell","surface","in","association","with","an","MHC","protein","complex","."),4233926). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationOfEndogenousPeptideAntigen',s("The","process","in","which","an","antigen-presenting","cell","expresses","a","peptide","antigen","of","endogenous","origin","on","its","cell","surface","in","association","with","an","MHC","protein","complex",".","The","peptide","is","typically","a","fragment","of","a","larger","endogenous","protein","which","has","been","degraded","within","the","cell","."),4233973). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationOfEndogenousPeptideAntigenViaMHCClassIb',s("The","process","in","which","an","antigen-presenting","cell","expresses","a","peptide","antigen","of","endogenous","origin","on","its","cell","surface","in","association","with","an","MHC","class","Ib","protein","complex",".","The","peptide","is","typically","a","fragment","of","a","larger","endogenous","protein","which","has","been","degraded","within","the","cell",".","Class","Ib","here","refers","to","non-classical","class","I","molecules",",","such","as","those","of","the","HLA-E","gene","family","."),4380582). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationOfEndogenousPeptideAntigenViaMHCClassIbViaERPathway',s("The","process","in","which","an","antigen-presenting","cell","expresses","a","peptide","antigen","of","endogenous","origin","on","its","cell","surface","in","association","with","an","MHC","class","Ib","protein","complex","following","intracellular","transport","via","an","ER","pathway",".","The","peptide","is","typically","a","fragment","of","a","larger","endogenous","protein","which","has","been","degraded","within","the","cell","and","becomes","associated","with","the","MHC","class","Ib","molecule","in","the","ER",".","Class","Ib","here","refers","to","non-classical","class","I","molecules",",","such","as","those","of","the","HLA-E","gene","family","."),4380585). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationOfEndogenousPeptideAntigenViaMHCClassII',s("The","process","in","which","an","antigen-presenting","cell","expresses","a","peptide","antigen","of","endogenous","origin","on","its","cell","surface","in","association","with","an","MHC","class","II","protein","complex",".","The","peptide","antigen","is","typically",",","but","not","always",",","processed","from","a","whole","protein","."),4380601). assertion_content_comment('tOboGo_AntigenProcessingAndPresentationOfEndogenousPeptideAntigenViaMHCClassI',s("The","process","in","which","an","antigen-presenting","cell","expresses","a","peptide","antigen","of","endogenous","origin","on","its","cell","surface","in","association","with","an","MHC","class","I","protein","complex",".","The","peptide","antigen","is","typically",",","but","not","always",",","processed","from","a","whole","protein",".","Class","I","here","refers","to","classical","class","I","molecules","."),4233976). 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assertion_content_comment('tOboGo_AntigenProcessingAndPresentationOfEndogenousPeptideAntigenViaMHCClassIViaERPathway',s("The","process","in","which","an","antigen-presenting","cell","expresses","a","peptide","antigen","of","endogenous","origin","on","its","cell","surface","in","association","with","an","MHC","class","I","protein","complex","following","intracellular","transport","via","an","ER","pathway",".","The","peptide","is","typically","a","fragment","of","a","larger","endogenous","protein","which","has","been","degraded","within","the","cell","and","becomes","associated","with","the","MHC","class","I","molecule","in","the","ER",".","Class","I","here","refers","to","classical","class","I","molecules","."),4380678). 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assertion_content_comment('tOboGo_AntigenProcessingAndPresentationOfPolysaccharideAntigenViaMHCClassII',s("The","process","in","which","an","antigen-presenting","cell","expresses","a","polysaccharide","antigen","on","its","cell","surface","in","association","with","an","MHC","class","II","protein","complex","."),3994782). assertion_content_comment('tOboGo_AntigenProcessingAndPresentation',s("The","process","in","which","an","antigen-presenting","cell","expresses","antigen","(","peptide","or","lipid",")","on","its","cell","surface","in","association","with","an","MHC","protein","complex","."),3993480). 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assertion_content_comment('tOboGo_AntimicrobialPeptideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","antimicrobial","peptide",".","Such","peptides","may","have","protective","properties","against","bacteria",",","fungi",",","viruses",",","or","protozoa","."),3997595). assertion_content_comment('tOboGo_AntimicrobialPeptideProduction',s("The","synthesis","or","release","of","an","antimicrobial","peptide","during","an","immune","response",",","resulting","in","an","increase","in","intracellular","or","extracellular","levels",".","Such","peptides","may","have","protective","properties","against","bacteria",",","fungi",",","viruses",",","or","protozoa","."),3993289). assertion_content_comment('tOboGo_AntimicrobialPeptideSecretion',s("The","regulated","release","of","an","antimicrobial","peptide","from","a","cell","or","group","of","cells",".","Such","peptides","may","have","protective","properties","against","bacteria",",","fungi",",","viruses",",","or","protozoa","."),3997306). assertion_content_comment('tOboGo_AntimoniteSecondaryActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","antimonite","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4316282). assertion_content_comment('tOboGo_AntimoniteTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","antimonite","from","one","side","of","a","membrane","to","the","other","."),4297479). assertion_content_comment('tOboGo_AntimoniteTransport',s("The","directed","movement","of","antimonite","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4289907). assertion_content_comment('tOboGo_AntioxidantActivity',s("Inhibition","of","the","reactions","brought","about","by","dioxygen","(","O2",")","or","peroxides",".","Usually","the","antioxidant","is","effective","because","it","can","itself","be","more","easily","oxidized","than","the","substance","protected",".","The","term","is","often","applied","to","components","that","can","trap","free","radicals",",","thereby","breaking","the","chain","reaction","that","normally","leads","to","extensive","biological","damage","."),4201904). assertion_content_comment('tOboGo_AntipodalCellDegeneration',s("The","process","in","which","the","antipodal","cells","undergo","programmed","cell","death","."),4107505). assertion_content_comment('tOboGo_AntipodalCellDifferentiation',s("The","process","in","which","an","uncellularized","nucleus","cellularizes","and","acquires","the","specialized","features","of","an","antipodal","cell","."),4023165). assertion_content_comment('tOboGo_AntipodalCellNucleus',s("The","nucleus","of","an","antipodal","cell",",","one","of","three","cells","of","the","embryo","sac","in","angiosperms",",","found","at","the","chalazal","end","of","the","embryo","away","from","the","point","of","entry","of","the","pollen","tube",",","and","its","descendents","."),4317844). assertion_content_comment('tOboGo_AntiporterActivity',s("Enables","the","active","transport","of","a","solute","across","a","membrane","by","a","mechanism","whereby","two","or","more","species","are","transported","in","opposite","directions","in","a","tightly","coupled","process","not","directly","linked","to","a","form","of","energy","other","than","chemiosmotic","energy","."),4020526). assertion_content_comment('tOboGo_Antiport',s("OBSOLETE",".","The","process","of","coupled","solute","translocation","in","which","two","solutes","equilibrate","across","an","osmotic","barrier",",","the","translocation","of","solute","being","coupled","to","the","translocation","of","the","other","in","the","opposite","direction","."),4294974). assertion_content_comment('tOboGo_AntisenseRNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","antisense","RNA",",","an","RNA","molecule","complementary","in","sequence","to","another","RNA","or","DNA","molecule",",","which",",","by","binding","the","latter",",","acts","to","inhibit","its","function","and/or","completion","of","synthesis","."),4115561). assertion_content_comment('tOboGo_AntisenseRNA',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259946). assertion_content_comment('tOboGo_AntisenseRNATranscriptCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","antisense","transcripts",",","i.e",".","transcripts","that","were","produced","from","the","antisense","strand","of","a","gene","that","produces","a","gene","product","and","which","often","have","a","regulatory","effect","on","the","transcription","of","that","gene","product","."),4167423). assertion_content_comment('tOboGo_AntisenseRNATranscription',s("The","synthesis","of","antisense","RNA",",","an","RNA","molecule","complementary","in","sequence","to","another","RNA","or","DNA","molecule",",","which",",","by","binding","the","latter",",","acts","to","inhibit","its","function","and/or","completion","of","synthesis",",","on","a","template","of","DNA","."),4115564). assertion_content_comment('tOboGo_AntisigmaFactorBinding',s("Interacting","selectively","and","non-covalently","with","an","antisigma","factor",",","a","factor","which","inhibits","the","ability","of","the","sigma","factor","to","function","as","a","transcriptional","initiator","."),4300388). assertion_content_comment('tOboGo_AntiviralResponseProteinActivity',s("OBSOLETE",".","A","protein","involved","in","an","antiviral","response","."),4187675). assertion_content_comment('tOboGo_AntralOvarianFollicleGrowth',s("Increase","in","size","of","antral","follicles","due","to","cell","proliferation","and/or","growth","of","the","antral","cavity","."),3981254). assertion_content_comment('tOboGo_AortaSmoothMuscleTissueMorphogenesis',s("The","process","in","which","the","structure","of","the","smooth","muscle","tissue","surrounding","the","aorta","is","generated","and","organized",".","The","aorta","originates","in","the","left","ventricle","of","the","heart","and","transports","oxygenated","blood","to","the","rest","of","the","body","."),4117510). assertion_content_comment('tOboGo_AorticValveDevelopment',s("The","progression","of","the","aortic","valve","over","time",",","from","its","formation","to","the","mature","structure","."),4002227). assertion_content_comment('tOboGo_AorticValveFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","aortic","valve","from","unspecified","parts",".","This","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","discrete","structure","and","ends","when","the","structural","rudiment","is","recognizable","."),4002366). assertion_content_comment('tOboGo_AorticValveMorphogenesis',s("The","process","in","which","the","structure","of","the","aortic","valve","is","generated","and","organized","."),4002237). assertion_content_comment('tOboGo_ApelinReceptorActivity',s("Combining","with","the","peptide","apelin","to","initiate","a","change","in","cell","activity","."),4159879). assertion_content_comment('tOboGo_ApelinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","apelin","receptor","."),4323097). assertion_content_comment('tOboGo_ApelinReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","apelin","receptor","binding","to","one","of","its","physiological","ligands","."),4159832). assertion_content_comment('tOboGo_APG12ActivatingEnzymeActivity',s("Catalysis","of","the","activation","of","the","small","ubiquitin-related","modifier","APG12",",","through","the","formation","of","an","ATP-dependent","high-energy","thiolester","bond","."),4245267). assertion_content_comment('tOboGo_APG12HydrolaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4234216). assertion_content_comment('tOboGo_APG8ActivatingEnzymeActivity',s("Catalysis","of","the","activation","of","the","small","ubiquitin-related","modifier","APG8",",","through","the","formation","of","an","ATP-dependent","high-energy","thiolester","bond","."),4245276). assertion_content_comment('tOboGo_ApicalCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","an","apical","cell",".","The","apical","cell","is","the","upper","cell","formed","after","the","first","division","of","the","zygote","."),4026327). assertion_content_comment('tOboGo_ApicalComplex',s("Protruding","complex","at","the","anterior","end","of","some","life","cycle","stages","of","all","apicomplexan","parasites",",","involved","in","both","the","attachment","and","penetration","of","the","host","cell","by","the","parasite","."),4041675). assertion_content_comment('tOboGo_ApicalConstrictionInvolvedInGastrulation',s("The","actin-mediated","process","that","results","in","the","contraction","of","the","apical","end","of","a","polarized","columnar","epithelial","cell",",","contributing","to","the","process","of","gastrulation","."),4005440). assertion_content_comment('tOboGo_ApicalConstriction',s("The","actin-mediated","process","that","results","in","the","contraction","of","the","apical","end","of","a","polarized","columnar","epithelial","cell","."),4005437). assertion_content_comment('tOboGo_ApicalCortex',s("The","region","that","lies","just","beneath","the","plasma","membrane","on","the","apical","edge","of","a","cell","."),4086103). assertion_content_comment('tOboGo_ApicalJunctionAssembly',s("The","formation","of","an","apical","junction",",","a","functional","unit","located","near","the","cell","apex","at","the","points","of","contact","between","epithelial","cells","composed","of","the","tight","junction",",","the","zonula","adherens","junction","and","the","desmosomes",",","by","the","aggregation",",","arrangement","and","bonding","together","of","its","constituents","."),4042040). assertion_content_comment('tOboGo_ApicalJunctionComplex',s("A","functional","unit","located","near","the","cell","apex","at","the","points","of","contact","between","epithelial","cells",",","which","in","vertebrates","is","composed","of","the","tight","junction",",","the","zonula","adherens",",","and","desmosomes","and","in","invertebrates","is","composed","of","the","subapical","complex","(","SAC",")",",","the","zonula","adherens","and","the","septate","junction",".","Functions","in","the","regulation","of","cell","polarity",",","tissue","integrity","and","intercellular","adhesion","and","permeability","."),4008128). assertion_content_comment('tOboGo_ApicalLaminaOfHyalineLayer',s("A","fibrous","network","that","is","part","of","the","hyalin","layer","extracellular","matrix",".","The","apical","lamina","is","thought","to","be","principally","composed","of","the","glycoproteins","fibropellins",".","This","matrix","has","been","found","in","echinoderms","."),4067444). assertion_content_comment('tOboGo_ApicalPartOfCell',s("The","region","of","a","polarized","cell","that","forms","a","tip","or","is","distal","to","a","base",".","For","example",",","in","a","polarized","epithelial","cell",",","the","apical","region","has","an","exposed","surface","and","lies","opposite","to","the","basal","lamina","that","separates","the","epithelium","from","other","tissue","."),4034581). assertion_content_comment('tOboGo_ApicalPlasmaMembrane',s("The","region","of","the","plasma","membrane","located","at","the","apical","end","of","the","cell","."),4034591). assertion_content_comment('tOboGo_ApicalPoleOfNeuron',s("Portion","of","a","neuron","cell","soma","closest","to","the","point","where","the","apical","dendrite","emerges","."),4098056). assertion_content_comment('tOboGo_ApicalProteinLocalization',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","apical","regions","of","the","cell","."),4300269). assertion_content_comment('tOboGo_ApicolateralPlasmaMembrane',s("The","apical","end","of","the","lateral","plasma","membrane","of","epithelial","cells","."),4008126). assertion_content_comment('tOboGo_Apicoplast',s("The","plastid","organelle","found","in","apicomplexans","."),4080656). assertion_content_comment('tOboGo_ApiogalacturonanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","pectic","apiogalacturonan",",","characterized","by","a","backbone","of","alpha-","(","1-","&","gt",";","4",")","-linked","D-galacturonic","acid","residues","substituted","with","apiose","and","apiobiose","(","D-apiofuranosyl-beta-","(","l-","&","gt",";","3",")","-D-apiose",")","side","chains","via","O-2","or","O-3","links","."),4332212). assertion_content_comment('tOboGo_ApioseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","apiose",",","the","branched","tetrose","3-C-","(","hydroxymethyl",")","-D-glycero-tetrose","."),4338717). assertion_content_comment('tOboGo_ApioseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","apiose",",","the","branched","tetrose","3-C-","(","hydroxymethyl",")","-D-glycero-tetrose","."),4338714). assertion_content_comment('tOboGo_AplanosporeFormation',s("The","process","in","which","a","nonmotile",",","asexual","spore","is","formed","within","a","cell","in","certain","algae","and","fungi","(","commonly","in","the","Phycomycetes",")",",","the","wall","of","aplanospore","is","distinct","from","that","of","the","parent","cell","."),4148217). assertion_content_comment('tOboGo_ApocarotenoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","apocarotenoids","by","the","oxidative","cleavage","of","carotenoids",".","Many","apocarotenoids","are","biologically","important","e.g",".","retinal","and","abscisic","acid","."),4032875). assertion_content_comment('tOboGo_ApocarotenoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","apocarotenoids",",","a","class","of","compounds","derived","from","the","oxidative","cleavage","of","carotenoids",",","many","of","which","are","biologically","important","e.g",".","retinal","and","abscisic","acid","."),4318532). assertion_content_comment('tOboGo_ApocarotenoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","apocarotenoids",",","a","class","of","compounds","derived","from","the","oxidative","cleavage","of","carotenoids",",","many","of","which","are","biologically","important","e.g",".","retinal","and","abscisic","acid","."),4032858). assertion_content_comment('tOboGo_ApolipoproteinBinding',s("Interacting","selectively","and","non-covalently","with","an","apolipoprotein",",","the","protein","component","of","a","lipoprotein","complex","."),4311712). assertion_content_comment('tOboGo_ApolipoproteinBMRNAEditingEnzymeComplex',s("Protein","complex","that","mediates","editing","of","the","mRNA","encoding","apolipoprotein","B",";","catalyzes","the","deamination","of","C","to","U","(","residue","6666","in","the","human","mRNA",")","Contains","a","catalytic","subunit",",","APOBEC-1",",","and","other","proteins","(","e.g",".","human","ASP",";","rat","ASP","and","KSRP",")"),4307002). assertion_content_comment('tOboGo_ApolipoproteinEBinding',s("Interacting","selectively","and","non-covalently","with","apolipoprotein","E","."),4359360). assertion_content_comment('tOboGo_ApolipoproteinEReceptorActivity',s("OBSOLETE",".","Combining","with","apolipoprotein","E","to","initiate","a","change","in","cell","activity","."),4311749). assertion_content_comment('tOboGo_ApolipoproteinEReceptorBinding',s("OBSOLETE",".","Interacting","selectively","with","an","apolipoprotein","E","receptor","."),4275773). assertion_content_comment('tOboGo_ApolipoproteinERecycling',s("The","process","in","which","chylomicron","remnant-associated","apolipoprotein","E","is","internalized","by","endocytosis",",","localized","to","recycling","endosomes","and","then","secreted","in","association","with","a","high-density","lipoprotein","particle","."),4125673). assertion_content_comment('tOboGo_ApolipoproteinReceptorActivity',s("Combining","with","an","apolipoprotein",",","the","protein","component","of","a","lipoprotein",",","to","initiate","a","change","in","cell","activity","."),4311714). assertion_content_comment('tOboGo_ApolipoproteinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","apolipoprotein","receptor","."),4359409). assertion_content_comment('tOboGo_Apolipoprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4216113). assertion_content_comment('tOboGo_Apolysis',s("The","first","process","of","molting",",","characterized","by","the","detachment","of","the","old","cuticle","from","the","underlying","epidermal","cells","."),4045300). assertion_content_comment('tOboGo_Apoplast',s("The","cell","membranes","and","intracellular","regions","in","a","plant","are","connected","through","plasmodesmata",",","and","plants","may","be","described","as","having","two","major","compartments",":","the","living","symplast","and","the","non-living","apoplast",".","The","apoplast","is","external","to","the","plasma","membrane","and","includes","cell","walls",",","intercellular","spaces","and","the","lumen","of","dead","structures","such","as","xylem","vessels",".","Water","and","solutes","pass","freely","through","it","."),4384604). assertion_content_comment('tOboGo_ApoptogenicCytochromeCReleaseChannelActivity',"OBSOLETE.",4295143). assertion_content_comment('tOboGo_ApoptosisActivatorActivity',s("OBSOLETE",".","The","function","held","by","products","which","directly","activate","any","step","in","the","process","of","apoptosis","."),4305436). assertion_content_comment('tOboGo_ApoptosisInBoneMarrow',s("The","process","of","apoptosis","in","cells","in","the","bone","marrow","."),4082012). assertion_content_comment('tOboGo_ApoptosisInhibitorActivity',s("OBSOLETE",".","The","function","held","by","products","which","directly","block","any","step","in","the","process","of","apoptosis","."),4246219). assertion_content_comment('tOboGo_ApoptosisInResponseToEndoplasmicReticulumStress',s("Apoptosis","that","occurs","in","response","to","a","stimulus","indicating","endoplasmic","reticulum","(","ER",")","stress",".","ER","stress","usually","results","from","the","accumulation","of","unfolded","or","misfolded","proteins","in","the","ER","lumen","."),4179988). assertion_content_comment('tOboGo_ApoptosisInvolvedInAtrialVentricularJunctionRemodeling',s("The","process","of","apoptosis","that","contributes","to","the","reorganization","of","tissue","resulting","in","the","maturation","of","the","atrial","ventricular","junction","."),4001809). assertion_content_comment('tOboGo_ApoptosisInvolvedInEndocardialCushionMorphogenesis',s("The","apoptosis","process","that","contributes","to","the","shaping","of","an","endocardial","cushion",".","The","endocardial","cushion","is","a","specialized","region","of","mesenchymal","cells","that","will","give","rise","to","the","heart","septa","and","valves","."),4001464). assertion_content_comment('tOboGo_ApoptosisInvolvedInHeartMorphogenesis',s("The","process","of","apoptosis","that","contributes","to","the","shaping","of","the","heart","."),4001403). assertion_content_comment('tOboGo_ApoptosisInvolvedInHeartValveMorphogenesis',s("The","apoptosis","process","that","contributes","to","the","shaping","of","a","heart","valve","."),4001454). assertion_content_comment('tOboGo_ApoptosisInvolvedInLuteolysis',s("The","process","of","apoptosis","that","contributes","to","luteolysis","."),4133573). assertion_content_comment('tOboGo_ApoptosisInvolvedInMammaryGlandInvolution',s("The","form","of","programmed","cell","death","that","triggers","the","activity","of","proteolytic","caspases",",","whose","actions","dismantle","the","mammary","epithelial","cells","resulting","in","their","death","."),4109270). assertion_content_comment('tOboGo_ApoptosisInvolvedInMorphogenesis',s("The","process","of","apoptosis","that","contributes","to","the","shaping","of","an","anatomical","structure","."),4001399). assertion_content_comment('tOboGo_ApoptosisInvolvedInOutflowTractMorphogenesis',s("The","apoptosis","process","that","contributes","to","the","shaping","of","the","outflow","tract",".","The","outflow","tract","is","the","portion","of","the","heart","through","which","blood","flows","into","the","arteries","."),4001423). assertion_content_comment('tOboGo_ApoptosisInvolvedInSalivaryGlandCavitation',s("The","apoptosis","process","in","which","the","solid","core","of","the","gland","is","hollowed","out","to","form","the","duct","."),4112056). assertion_content_comment('tOboGo_ApoptosisInvolvedInTubeLumenCavitation',s("The","process","of","apoptosis","that","contributes","to","the","hollowing","out","of","an","epithelial","rod","or","cord","to","form","the","central","hole","in","a","tube","."),4111807). assertion_content_comment('tOboGo_ApoptosisRegulatorActivity',s("OBSOLETE",".","The","function","held","by","products","which","directly","regulate","any","step","in","the","process","of","apoptosis","."),4304359). assertion_content_comment('tOboGo_Apoptosis',s("A","form","of","programmed","cell","death","that","begins","when","a","cell","receives","internal","or","external","signals","that","trigger","the","activity","of","proteolytic","caspases",",","proceeds","through","a","series","of","characteristic","stages","typically","including","rounding-up","of","the","cell",",","retraction","of","pseudopodes",",","reduction","of","cellular","volume","(","pyknosis",")",",","chromatin","condensation",",","nuclear","fragmentation","(","karyorrhexis",")",",","and","plasma","membrane","blebbing","(","but","maintenance","of","its","integrity","until","the","final","stages","of","the","process",")",",","and","ends","with","the","death","of","the","cell","."),3981312). 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assertion_content_comment('tOboGo_ApoptoticNuclearChange',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","disassembly","of","the","nucleus","and","contributes","to","apoptosis","."),4011227). assertion_content_comment('tOboGo_ApoptoticProteaseActivatorActivity',s("Increases","the","activity","of","a","peptidase","that","is","involved","in","the","activation","of","apoptosis","."),4253242). assertion_content_comment('tOboGo_AppendageDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","appendage","over","time",",","from","its","formation","to","the","mature","structure",".","An","appendage","is","an","organ","or","part","that","is","attached","to","the","trunk","of","an","organism",",","such","as","a","limb","or","a","branch","."),3982429). assertion_content_comment('tOboGo_AppendageMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","appendages","are","generated","and","organized",".","An","appendage","is","an","organ","or","part","that","is","attached","to","the","trunk","of","an","organism",",","such","as","a","limb","or","a","branch","."),3982431). assertion_content_comment('tOboGo_AppendageSegmentation',s("Division","of","an","appendage",",","an","organ","or","part","that","is","attached","to","the","main","body","of","an","organism",",","into","a","series","of","semi-repetitive","parts","or","segments",".","Most","arthropod","appendages",",","such","as","the","legs","and","antennae",",","are","visibly","segmented","."),4034496). assertion_content_comment('tOboGo_AppressoriumFormationOnOrNearHost',s("The","process","in","which","a","swollen",",","flattened","portion","of","a","symbiont","filament","is","formed","on","or","near","its","host","organism",",","to","adhere","to","and","for","the","purpose","of","penetrating","the","host","surface",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4145936). assertion_content_comment('tOboGo_ApyraseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","2","H2O","=","AMP","+","2","phosphate","."),4213693). assertion_content_comment('tOboGo_AquacobalaminReductaseActivity',s("Catalysis","of","the","reaction",":","2","cob","(","II",")","alamin","+","NAD","+","=","2","aquacob","(","III",")","alamin","+","NADH","+","H","+"),4365626). assertion_content_comment('tOboGo_AquacobalaminReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","2","cob","(","II",")","alamin","+","NADP","+","=","2","aquacob","(","III",")","alamin","+","NADPH","+","H","+"),4267052). assertion_content_comment('tOboGo_ArabidiolSynthaseActivity',s("Catalysis","of","the","reaction",":","oxidosqualene","+","H2O","=","arabidiol","(","(","13R",",","14R",",","17E",")","-malabarica-17",",","21-diene-3beta",",","14-diol",")"),4361189). assertion_content_comment('tOboGo_ArabinanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arabinan",",","a","branched","homopolymer","of","L-arabinose","."),4320012). assertion_content_comment('tOboGo_ArabinanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","arabinan",",","a","branched","homopolymer","of","L-arabinose","."),4320001). assertion_content_comment('tOboGo_ArabinitolTransport',s("The","directed","movement","of","arabitol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Arabitol","is","the","pentitol","derived","from","arabinose","or","lyxose","by","reduction","of","the","aldehyde","group",".","The","D","enantiomer","is","present","in","lichens","and","mushrooms","."),4291010). assertion_content_comment('tOboGo_ArabinogalactanProteinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","cell","wall","arabinogalactan","II","glycoprotein",",","which","is","composed","of","a","group","of","core","protein","of","highly","varying","length","and","domain","complexity",".","These","are","O-glycosylated","at","one","or","more","hydroxyproline","residues","by","arabinogalactan","(","AG",")","type","II","groups",",","which","consist","of","(","1-","&","gt",";","3",")","-beta-galactan","and","(","1-","&","gt",";","6",")","-beta-linked","galactan","chains","connected","to","each","other","by","(","1-","&","gt",";","3",",","1-","&","gt",";","6",")","-linked","branch","points",",","O-3","and","O-6","positions","substituted","with","terminal","arabinosyl","residues",".","Also",",","rhamnose",",","fucose",",","glucuronic","and","galacturonic","acid","can","be","present","in","the","glycan","structures","."),4332978). assertion_content_comment('tOboGo_ArabinonateDehydrataseActivity',s("Catalysis","of","the","reaction",":","D-arabinonate","=","2-dehydro-3-deoxy-D-arabinonate","+","H","(","2",")","O","."),4372926). assertion_content_comment('tOboGo_ArabinoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","arabinose",",","arabino-pentose","."),4242860). assertion_content_comment('tOboGo_ArabinoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arabinose",",","arabino-pentose","."),4242795). assertion_content_comment('tOboGo_ArabinoseEffluxTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","arabinose","from","the","inside","of","the","cell","to","the","outside","of","the","cell","across","a","membrane",":","H","+","(","out",")","+","arabinose","(","in",")","=","H","+","(","in",")","+","arabinose","(","out",")"),4292877). assertion_content_comment('tOboGo_Arabinose_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","arabinose","(","out",")","+","H","+","(","out",")","=","arabinose","(","in",")","+","H","+","(","in",")"),4292828). assertion_content_comment('tOboGo_ArabinoseIsomeraseActivity',s("Catalysis","of","the","reaction",":","D-arabinose","=","D-ribulose","."),4248880). assertion_content_comment('tOboGo_ArabinoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","arabinose",",","arabino-pentose",".","L-Arabinose","occurs","both","free",",","for","example","in","the","heartwood","of","many","conifers",",","and","in","the","combined","state",",","as","a","constituent","of","plant","hemicelluloses",",","bacterial","polysaccharides","etc",".","D-arabinose","is","a","constituent","of","arabinonucleosides","."),4242792). assertion_content_comment('tOboGo_ArabinosePolymerTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","an","arabinose","polymer",",","a","repeating","chain","of","arabinose","monomers",",","from","one","side","of","the","membrane","to","the","other","."),4316033). assertion_content_comment('tOboGo_ArabinosePolymerTransport',s("The","directed","movement","of","an","arabinose","polymer",",","a","repeating","chain","of","arabinose","monomers",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4315076). assertion_content_comment('tOboGo_ArabinoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","arabinose",",","a","pentose","monosaccharide","that","occurs","in","both","D","and","L","configurations",",","and","as","a","polymer",",","from","one","side","of","the","membrane","to","the","other","."),4289680). assertion_content_comment('tOboGo_ArabinoseTransport',s("The","directed","movement","of","arabinose",",","a","pentose","monosaccharide","that","occurs","in","both","D","and","L","configurations",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4291042). assertion_content_comment('tOboGo_ArabinosyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","pentosyl","group","from","one","compound","(","donor",")","to","another","(","acceptor",")"),4182699). assertion_content_comment('tOboGo_ArabinoxylanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","xylan",",","a","polymer","containing","a","beta-1",",","4-linked","D-xylose","backbone","decorated","with","arabinose","side","units","."),4333526). assertion_content_comment('tOboGo_ArabitolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arabitol",",","the","pentitol","derived","from","arabinose","or","lyxose","by","reduction","of","the","aldehyde","group","."),4242449). assertion_content_comment('tOboGo_ArabitolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","arabitol",",","the","pentitol","derived","from","arabinose","or","lyxose","by","reduction","of","the","aldehyde","group","."),4242446). assertion_content_comment('tOboGo_ArabitolTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","an","arabitol","from","one","side","of","the","membrane","to","the","other",".","Arabitol","is","the","pentitol","derived","from","arabinose","or","lyxose","by","reduction","of","the","aldehyde","group",".","The","D","enantiomer","is","present","in","lichens","and","mushrooms","."),4297440). assertion_content_comment('tOboGo_ArachidonicAcidBinding',s("Interacting","selectively","and","non-covalently","with","arachidonic","acid",",","a","straight","chain","fatty","acid","with","20","carbon","atoms","and","four","double","bonds","per","molecule",".","Arachidonic","acid","is","the","all-Z-","(","5",",","8",",","11",",","14",")","-isomer","."),4268903). assertion_content_comment('tOboGo_ArachidonicAcidEpoxygenaseActivity',s("Catalysis","of","an","NADPH-","and","oxygen-dependent","reaction","that","converts","arachidonic","acid","to","a","cis-epoxyeicosatrienoic","acid","."),4255673). assertion_content_comment('tOboGo_ArachidonicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","arachidonic","acid",",","a","straight","chain","fatty","acid","with","20","carbon","atoms","and","four","double","bonds","per","molecule",".","Arachidonic","acid","is","the","all-Z-","(","5",",","8",",","11",",","14",")","-isomer","."),4045831). assertion_content_comment('tOboGo_ArachidonicAcidMetaboliteProductionInvolvedInInflammatoryResponse',s("The","synthesis","or","release","of","products","of","arachidonic","acid","metabolism","following","a","stimulus","as","part","of","an","inflammatory","response",",","resulting","in","an","increase","in","their","intracellular","or","extracellular","levels","."),4084349). assertion_content_comment('tOboGo_ArachidonicAcidMonooxygenaseActivity',s("Catalysis","of","the","incorporation","of","one","atom","from","molecular","oxygen","into","arachidonic","acid","and","the","reduction","of","the","other","atom","of","oxygen","to","water","."),4255670). assertion_content_comment('tOboGo_ArachidonicAcidSecretion',s("The","controlled","release","of","arachidonic","acid","from","a","cell","or","group","of","cells","."),4151555). assertion_content_comment('tOboGo_AralkylamineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","R-CH2-NH2","+","H2O","+","acceptor","=","R-CHO","+","NH3","+","reduced","acceptor","."),4306658). assertion_content_comment('tOboGo_Arbuscule',s("Highly","branched","symbiont","haustoria","within","host","root","cortex","cells",",","responsible","for","nutrient","exchange","."),4084018). assertion_content_comment('tOboGo_ArbutinTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","arbutin",",","a","glycoside","found","in","the","bearberry","and","related","plants","which","has","been","used","to","treat","urinary-tract","diseases",",","from","one","side","of","the","membrane","to","the","other","."),4316375). assertion_content_comment('tOboGo_ArbutinTransport',s("The","directed","movement","of","arbutin",",","a","glycoside","found","in","the","bearberry","and","related","plants","which","has","been","used","to","treat","urinary-tract","diseases",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4315675). assertion_content_comment('tOboGo_ARCComplex',s("A","ribonucleoprotein","complex","that","contains","members","of","the","Argonaute","family","of","proteins",",","additional","protein","subunits",",","and","duplex","siRNA",";","required","for","heterochromatin","assembly","and","siRNA","generation",".","Possibly","involved","in","the","conversion","of","ds","siRNA","to","ss","siRNA","."),4347813). assertion_content_comment('tOboGo_ArchaetidylserineSynthaseActivity',s("Catalysis","of","the","reaction",":","CDP-digeranylgeranylglycerol","+","L-serine","=","archaetidylserine","+","CMP","."),4326083). assertion_content_comment('tOboGo_ARFGTPaseActivatorActivity',s("Increases","the","rate","of","GTP","hydrolysis","by","the","GTPase","ARF","."),4247273). assertion_content_comment('tOboGo_ARFProteinSignalTransduction',s("A","series","of","molecular","signals","within","the","cell","that","are","mediated","by","a","member","of","the","ARF","family","of","proteins","switching","to","a","GTP-bound","active","state","."),4056359). assertion_content_comment('tOboGo_ARFSmallMonomericGTPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate","."),4185644). assertion_content_comment('tOboGo_ArginaseActivity',s("Catalysis","of","the","reaction",":","L-arginine","+","H2O","=","L-ornithine","+","urea","."),4213703). assertion_content_comment('tOboGo_Arginine_AgmatineAntiporterActivity',s("Catalysis","of","the","reaction",":","arginine","(","out",")","+","agmatine","(","in",")","=","arginine","(","in",")","+","agmatine","(","out",")"),4326988). assertion_content_comment('tOboGo_ArginineBinding',s("Interacting","selectively","and","non-covalently","with","2-amino-5-","(","carbamimidamido",")","pentanoic","acid","."),4353698). assertion_content_comment('tOboGo_ArginineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","arginine",",","2-amino-5-","(","carbamimidamido",")","pentanoic","acid","."),4139252). assertion_content_comment('tOboGo_ArginineBiosyntheticProcessViaOrnithine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","arginine","(","2-amino-5-guanidinopentanoic","acid",")","via","the","intermediate","compound","ornithine","."),4139270). assertion_content_comment('tOboGo_ArginineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine",",","2-amino-5-","(","carbamimidamido",")","pentanoic","acid","."),4231739). assertion_content_comment('tOboGo_ArginineCatabolicProcessToAlanineViaOrnithine',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine","into","other","compounds",",","including","alanine",",","via","ornithine","."),4334500). assertion_content_comment('tOboGo_ArginineCatabolicProcessToGlutamate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine","into","other","compounds",",","including","glutamate","."),4242162). assertion_content_comment('tOboGo_ArginineCatabolicProcessToOrnithine',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine","into","other","compounds",",","including","ornithine","."),4242149). assertion_content_comment('tOboGo_ArginineCatabolicProcessToProline',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine","into","other","compounds",",","including","proline","."),4240866). assertion_content_comment('tOboGo_ArginineCatabolicProcessToProlineViaOrnithine',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine","into","other","compounds",",","including","proline",",","via","ornithine","."),4334512). assertion_content_comment('tOboGo_ArginineCatabolicProcessToSpermine',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine","into","other","compounds",",","including","spermine","."),4242113). assertion_content_comment('tOboGo_ArginineCatabolicProcessToSuccinate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine","into","other","compounds",",","including","succinate","."),4242175). assertion_content_comment('tOboGo_ArginineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","L-arginine","+","H","(","+",")","=","agmatine","+","CO","(","2",")"),4248954). assertion_content_comment('tOboGo_ArginineDeiminaseActivity',s("Catalysis","of","the","reaction",":","L-arginine","+","H2O","=","L-citrulline","+","NH3","."),4302363). assertion_content_comment('tOboGo_ArginineDeiminasePathway',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arginine","into","other","compounds",",","including","ornithine","and","CO2",",","using","the","enzyme","arginine","deiminase","."),4242138). assertion_content_comment('tOboGo_ArginineKinaseActivity',s("Catalysis","of","the","reaction",":","L-arginine","+","ATP","=","N","(","omega",")","-phospho-L-arginine","+","ADP","+","2","H","(","+",")"),4213619). assertion_content_comment('tOboGo_ArginineLysineEndopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","linkages","in","oligopeptides","or","polypeptides","by","a","reaction","mechanism","in","which","arginine","or","lysine","residues","act","as","nucleophiles","."),4332564). assertion_content_comment('tOboGo_ArginineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","arginine",",","2-amino-5-","(","carbamimidamido",")","pentanoic","acid","."),3979018). assertion_content_comment('tOboGo_Arginine_OrnithineAntiporterActivity',s("Catalysis","of","the","reaction",":","arginine","(","out",")","+","ornithine","(","in",")","=","arginine","(","in",")","+","ornithine","(","out",")"),4327016). assertion_content_comment('tOboGo_ArginineRacemaseActivity',s("Catalysis","of","the","reaction",":","L-arginine","=","D-arginine","."),4372962). assertion_content_comment('tOboGo_ArginineTargetingTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","fully","folded","proteins","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","targeting","the","proteins","to","the","transporter","via","a","specialized","N-terminal","twin","arginine","signal","peptide","."),4293395). assertion_content_comment('tOboGo_ArginineTransmembraneTransporterActivity',s("Catalysis","of","the","stereospecific","transfer","of","arginine",",","2-amino-5-guanidinopentanoic","acid",",","across","a","biological","membrane","."),4215602). assertion_content_comment('tOboGo_ArginineTransport',s("The","directed","movement","of","arginine",",","2-amino-5-guanidinopentanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4035069). assertion_content_comment('tOboGo_ArgininosuccinateLyaseActivity',s("Catalysis","of","the","reaction",":","N-","(","L-arginino",")","succinate","=","fumarate","+","L-arginine","."),4213651). assertion_content_comment('tOboGo_ArgininosuccinateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","argininosuccinate",",","2-","(","N","(","omega",")","-arginino",")","succinate",",","an","intermediate","in","the","ornithine-urea","cycle",",","where","it","is","synthesized","from","citrulline","and","aspartate","."),4345635). assertion_content_comment('tOboGo_ArgininosuccinateSynthaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","L-citrulline","+","L-aspartate","=","AMP","+","diphosphate","+","(","N","(","omega",")","-L-arginino",")","succinate","."),4213603). assertion_content_comment('tOboGo_ArginyltransferaseActivity',s("Catalysis","of","the","reaction",":","L-arginyl-tRNA","+","protein","=","tRNA","+","L-arginyl-protein","."),4213634). assertion_content_comment('tOboGo_AristolocheneSynthaseActivity',s("Catalysis","of","the","reaction",":","trans",",","trans-farnesyl","diphosphate","=","aristolochene","+","diphosphate","."),4299698). assertion_content_comment('tOboGo_ArmadilloRepeatDomainBinding',s("Interacting","selectively","and","non-covalently","with","the","armadillo","repeat","domain","of","a","protein",",","an","approximately","40","amino","acid","long","tandemly","repeated","sequence","motif","first","identified","in","the","Drosophila","segment","polarity","protein","armadillo",".","Arm-repeat","proteins","are","involved","in","various","processes",",","including","intracellular","signalling","and","cytoskeletal","regulation","."),4180345). assertion_content_comment('tOboGo_ArmMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","arm","are","generated","and","organized",".","In","humans",",","the","arms","are","the","two","upper","limbs","of","the","body","from","the","shoulder","to","the","hand","."),4382127). assertion_content_comment('tOboGo_ArogenateDehydrataseActivity',s("Catalysis","of","the","reaction",":","L-arogenate","=","L-phenylalanine","+","H2O","+","CO2","."),4374183). assertion_content_comment('tOboGo_ArogenateDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","L-arogenate","+","NAD","(","P",")","+","=","L-tyrosine","+","NAD","(","P",")","H","+","CO2","."),4342600). assertion_content_comment('tOboGo_AromataseActivity',s("Catalysis","of","the","reduction","of","an","aliphatic","ring","to","yield","an","aromatic","ring","."),4173236). 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assertion_content_comment('tOboGo_AromaticAminoAcidFamilyCatabolicProcessToAlcoholViaEhrlichPathway',s("The","chemical","reactions","and","pathways","involving","the","catabolism","of","aromatic","amino","acids","to","produce","aromatic","alcohols","with","one","carbon","less","than","the","starting","amino","acid",".","In","S",".","cerevisiae",",","this","is","known","to","occur","for","leucine",",","isoleucine",",","valine",",","methionine",",","phenylalanine",",","tyrosine",",","or","tryptophan",".","When","an","aromatic","family","amino","acid",",","phenylalanine",",","tyrosine",",","or","tryptophan",",","is","used","as","the","substrate",",","2-phenylethanol",",","4-hydroxyphenylethanol",",","or","tryptophol",",","respectively",",","is","produced",".","Often","referred","to","as","the","Ehrlich","pathway",",","these","reactions","generally","occur","during","fermentation","to","produce","a","variety","of","alcohols",",","often","collectively","referred","to","as","fusel","alcohols",".","Depending","on","the","redox","state","of","the","cells",",","carboxylic","acid","derivatives","may","be","produced","instead","of","alcohols","."),4363116). 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assertion_content_comment('tOboGo_AromaticAminoAcidTransport',s("The","directed","movement","of","aromatic","amino","acids",",","amino","acids","with","aromatic","ring",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293780). assertion_content_comment('tOboGo_AromaticCompoundBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aromatic","compounds",",","any","substance","containing","an","aromatic","carbon","ring","."),4014187). assertion_content_comment('tOboGo_AromaticCompoundCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","aromatic","compounds",",","any","substance","containing","an","aromatic","carbon","ring","."),4156652). assertion_content_comment('tOboGo_Arp23ComplexBinding',s("Interacting","selectively","and","non-covalently","with","an","Arp2/3","complex",",","a","protein","complex","that","contains","two","actin-related","proteins",",","Arp2","and","Arp3",",","and","five","novel","proteins","(","ARPC1-5",")"),4168096). assertion_content_comment('tOboGo_Arp23ProteinComplex',s("A","stable","protein","complex","that","contains","two","actin-related","proteins",",","Arp2","and","Arp3",",","and","five","novel","proteins","(","ARPC1-5",")",",","and","functions","in","the","nucleation","of","branched","actin","filaments","."),4008304). assertion_content_comment('tOboGo_ArsenateReductaseActivity',s("Catalysis","of","the","interconversion","of","arsenate","and","arsenite","."),4248902). assertion_content_comment('tOboGo_ArsenateReductaseAzurinActivity',s("Catalysis","of","the","reaction",":","2","azurin","(","ox",")","+","H2O","+","arsenite","=","2","azurin","(","red",")","+","arsenate","."),4278063). assertion_content_comment('tOboGo_ArsenateReductaseDonorActivity',s("Catalysis","of","the","reaction",":","A","+","arsenite","+","H","(","2",")","O","=","AH","(","2",")","+","arsenate","+","2","H","(","+",")"),4278074). assertion_content_comment('tOboGo_ArsenateReductaseGlutaredoxinActivity',s("Catalysis","of","the","reaction",":","arsenate","+","reduced","glutaredoxin","=","arsenite","+","oxidized","glutaredoxin",".","Glutaredoxin","functions","as","the","electron","donor","for","arsenate","reduction",".","The","electron","flow","therefore","is","(","NADPH","-","&","gt",";","glutathione","reductase","(","EC",":","1.6.4.2",")","-","&","gt",";",")","glutathione","-","&","gt",";","glutaredoxin","-","&","gt",";","arsenate","reductase",",","i.e",".","glutathione","is","reduced","by","glutathione","reductase","and","glutaredoxin","is","reduced","by","glutathione","."),4248928). assertion_content_comment('tOboGo_ArsenateReductaseThioredoxinActivity',s("Catalysis","of","the","reaction",":","arsenate","+","thioredoxin","=","arsenite","+","thioredoxin","disulfide",".","Thioredoxin","disulfide","is","also","known","as","oxidized","thioredoxin","."),4307978). assertion_content_comment('tOboGo_ArsenateSensitivityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4257942). assertion_content_comment('tOboGo_ArseniteMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","arsenite","=","S-adenosyl-L-homocysteine","+","methylarsonate","."),4309111). assertion_content_comment('tOboGo_ArseniteSecondaryActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","arsenite","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4254530). assertion_content_comment('tOboGo_ArseniteTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","arsenite","from","one","side","of","a","membrane","to","the","other","."),4254527). assertion_content_comment('tOboGo_ArseniteTransport',s("The","directed","movement","of","arsenite","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290908). assertion_content_comment('tOboGo_ArsonoacetateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","arsonoacetate",",","a","synthetic",",","organic","compound","containing","a","single","arsenic","atom","."),4242548). assertion_content_comment('tOboGo_ArsonoacetateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","arsonoacetate",",","a","synthetic",",","organic","compound","containing","a","single","arsenic","atom",".","Arsonoacetate","and","other","arsenic","containing","compounds","are","used","in","agricultural","applications","as","animal","feed","additives",",","cotton","defoliants","and","post-emergence","grass","herbicides","."),4242544). assertion_content_comment('tOboGo_ArterialEndothelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","endothelial","cell","acquires","specialized","features","of","an","arterial","endothelial","cell",",","a","thin","flattened","cell","that","lines","the","inside","surfaces","of","arteries","."),4113793). assertion_content_comment('tOboGo_ArterialEndothelialCellFateCommitment',s("The","commitment","of","a","cell","to","an","arterial","endothelial","cell","fate","and","its","capacity","to","differentiate","into","an","arterial","endothelial","cell","."),4113813). assertion_content_comment('tOboGo_ArterioleSmoothMuscleContraction',s("A","process","in","which","force","is","generated","within","smooth","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","This","process","occurs","in","the","arteriole",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","arteriole","is","the","smallest","division","of","the","artery","located","between","the","muscular","arteries","and","the","capillaries","."),4321171). assertion_content_comment('tOboGo_ArteryDevelopment',s("The","progression","of","the","artery","over","time",",","from","its","initial","formation","to","the","mature","structure",".","An","artery","is","a","blood","vessel","that","carries","blood","away","from","the","heart","to","a","capillary","bed","."),4105472). assertion_content_comment('tOboGo_ArteryMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","arterial","blood","vessels","are","generated","and","organized",".","Arteries","are","blood","vessels","that","transport","blood","from","the","heart","to","the","body","and","its","organs","."),4105482). assertion_content_comment('tOboGo_ArterySmoothMuscleContraction',s("A","process","in","which","force","is","generated","within","smooth","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","This","process","occurs","in","the","artery",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","artery","is","a","vessel","carrying","blood","away","from","the","heart","."),4321169). assertion_content_comment('tOboGo_ArthrosporeFormation',s("The","formation","of","conidia","by","the","conversion","of","a","pre-existing","hypha",".","An","arthrospore","is","produced","by","the","last","cell","on","a","hypha","breaking","off","and","dispersing",".","Usually","the","walls","thicken","and","the","cell","(","s",")","separates","before","swelling","of","each","spore",".","Sometimes","further","septa","form","in","each","cell","prior","to","disarticulation","."),4360120). assertion_content_comment('tOboGo_ArylacetonitrilaseActivity',s("Catalysis","of","the","reaction",":","2","H2O","+","4-chlorophenylacetonitrile","=","4-chlorophenylacetate","+","NH3","."),4370255). assertion_content_comment('tOboGo_ArylalkylAcylamidaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","N-acetylarylalkylamine","=","acetate","+","arylalkylamine","."),4370043). assertion_content_comment('tOboGo_ArylamineGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","an","arylamine","=","UDP","+","an","N-D-glucosylarylamine","."),4372814). assertion_content_comment('tOboGo_AryldialkylphosphataseActivity',s("Catalysis","of","the","reaction",":","aryl","dialkyl","phosphate","+","H2O","=","dialkyl","phosphate","+","an","aryl","alcohol","."),4212782). assertion_content_comment('tOboGo_ArylesteraseActivity',s("Catalysis","of","the","reaction",":","a","phenyl","acetate","+","H2O","=","a","phenol","+","acetate","."),4212807). assertion_content_comment('tOboGo_ArylformamidaseActivity',s("Catalysis","of","the","reaction",":","N-formyl-L-kynurenine","+","H2O","=","formate","+","L-kynurenine","."),4212742). assertion_content_comment('tOboGo_ArylHydrocarbonReceptorActivity',s("Combining","with","an","aryl","hydrocarbon","to","initiate","a","change","in","cell","activity","."),4200409). assertion_content_comment('tOboGo_ArylHydrocarbonReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","aryl","hydrocarbon","receptor","."),4257898). assertion_content_comment('tOboGo_ArylHydrocarbonReceptorComplex',s("A","protein","complex","that","acts","as","an","aryl","hydrocarbon","(","Ah",")","receptor",".","Cytosolic","and","nuclear","Ah","receptor","complexes","have","different","subunit","composition",",","but","both","contain","the","ligand-binding","subunit","AhR","."),4349490). assertion_content_comment('tOboGo_ArylHydrocarbonReceptorNuclearTranslocatorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4214959). assertion_content_comment('tOboGo_ArylmalonateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","2-aryl-2-methylmalonate","+","H","(","+",")","=","2-arylpropionate","+","CO","(","2",")"),4370334). assertion_content_comment('tOboGo_ArylsulfataseActivity',s("Catalysis","of","the","reaction",":","a","phenol","sulfate","+","H2O","=","a","phenol","+","sulfate","."),4212687). assertion_content_comment('tOboGo_ArylsulfateSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","an","aryl","sulfate","+","a","phenol","=","a","phenol","+","an","aryl","sulfate","."),4372787). assertion_content_comment('tOboGo_ArylSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","a","phenol","=","adenosine","3","'",",","5","'","-bisphosphate","+","an","aryl","sulfate","."),4212759). assertion_content_comment('tOboGo_AscendingThinLimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","ascending","thin","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","ascending","thin","limb","is","a","segment","of","a","nephron","tubule","lying","in","the","inner","medulla","that","is","permeable","to","ions","but","not","to","water","and","has","a","simple","epithelium",";","active","transepithelial","solute","transport","is","absent","."),4124979). assertion_content_comment('tOboGo_AscopyroneTautomeraseActivity',s("Catalysis","of","the","reaction",":","1",",","5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose","=","1",",","5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose","."),4360726). 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assertion_content_comment('tOboGo_AscosporeReleaseFromAscus',s("A","developmental","process","that","results","in","the","discharge","of","ascospores","from","the","ascus",".","Ascospore","release","may","be","active","or","passive","."),4125705). assertion_content_comment('tOboGo_AscosporeWallAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","ascospore","wall",".","During","sporulation","in","Ascomycota",",","each","ascospore","nucleus","becomes","surrounded","by","a","specialized","spore","wall",",","formed","by","deposition","of","spore","wall","components","in","the","lumenal","space","between","the","outer","and","inner","leaflets","of","the","prospore","membrane",".","An","example","of","this","process","is","found","in","Saccharomyces","cerevisiae","."),4046994). assertion_content_comment('tOboGo_AscosporeWallBiogenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","an","ascospore","wall","."),4046953). assertion_content_comment('tOboGo_AscosporeWallChitinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ascospore","wall","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues",",","found","in","the","walls","of","ascospores","."),4075446). assertion_content_comment('tOboGo_AscosporeWallChitinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ascospore","wall","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues",",","found","in","the","walls","of","ascospores","."),4075634). assertion_content_comment('tOboGo_AscosporeWallChitinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ascospore","wall","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues",",","found","in","the","walls","of","ascospores","."),4075409). assertion_content_comment('tOboGo_AscosporeWall',s("The","specialized","cell","wall","of","the","ascospore","(","spore",")",",","which","is","the","product","of","meiotic","division",".","Examples","of","this","component","are","found","in","Fungi","."),4006997). assertion_content_comment('tOboGo_AscusDevelopment',s("The","process","that","leads","to","the","development","of","ascus",",","a","sac-like","structure","produced","by","fungi","of","the","phylum","Ascomycota","(","sac","fungi",")","in","which","sexually","produced","spores","(","ascospores",")",",","usually","four","or","eight","in","number",",","are","formed","."),4147921). assertion_content_comment('tOboGo_AscusEpiplasm',s("An","extracellular","part","that","consist","of","ascus","cytoplasm","that","is","not","packaged","into","ascospores","."),4158741). assertion_content_comment('tOboGo_AscusLipidParticle',s("Any","particle","of","coalesced","lipids","in","an","ascus","or","ascospore",".","May","include","associated","proteins","."),4220351). assertion_content_comment('tOboGo_Ascus',s("OBSOLETE",".","A","sac-like","fruiting","body","(","ascomycete","Fungi",")",";","contains","ascospores","(","typically","eight","in","number",")"),4219977). assertion_content_comment('tOboGo_AsexualReproduction',s("The","biological","process","in","which","new","individuals","are","produced","by","either","a","single","cell","or","a","group","of","cells",",","in","the","absence","of","any","sexual","process","."),3978823). assertion_content_comment('tOboGo_AsexualSporeWallAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","asexual","spore","wall",",","the","specialized","envelope","lying","outside","the","cell","membrane","of","a","spore","derived","from","a","product","of","mitosis",".","Examples","of","this","process","are","found","in","Bacterial","species","."),4079317). assertion_content_comment('tOboGo_AsexualSporulationResultingInFormationOfACellularSpore',s("The","formation","of","a","cellular","spore","derived","from","the","products","of","mitosis",".","A","cellular","spore","is","a","cell","form","that","can","be","used","for","dissemination",",","for","survival","of","adverse","conditions","because","of","its","heat","and","dessication","resistance",",","and/or","for","reproduction","."),4096495). assertion_content_comment('tOboGo_AsexualSporulationResultingInFormationOfAMulticellularOrSyncytialSpore',s("The","formation","of","a","multicellular","or","syncytial","spore","via","septations","derived","from","mitosis","."),4154461). assertion_content_comment('tOboGo_AsexualSporulation',s("The","formation","of","spores","derived","from","the","products","of","mitosis",".","Examples","of","this","process","are","found","in","Bacterial","species","."),4075300). assertion_content_comment('tOboGo_AsialoglycoproteinReceptorActivity',s("The","mediation","of","the","endocytosis","of","plasma","glycoproteins","from","which","the","terminal","sialic","acid","residue","on","their","complex","carbohydrate","groups","has","been","removed",";","recognizes","the","terminal","galactose","and","N-acetylgalactosamine","units",";","the","complex","of","receptor","and","ligand","is","internalized","and","transported","to","a","sorting","organelle","where","disassociation","occurs",",","the","receptor","being","recycled","to","the","cell","membrane","."),4200400). assertion_content_comment('tOboGo_AsparaginaseActivity',s("Catalysis","of","the","reaction",":","L-asparagine","+","H2O","=","L-aspartate","+","NH3","."),4184755). assertion_content_comment('tOboGo_AsparagineBiosyntheticProcessFromCysteine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","asparagine","from","other","compounds",",","including","cysteine","."),4238238). assertion_content_comment('tOboGo_AsparagineBiosyntheticProcessFromOxaloacetate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","asparagine","from","other","compounds",",","including","oxaloacetate","."),4238196). assertion_content_comment('tOboGo_AsparagineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","asparagine",",","2-amino-3-carbamoylpropanoic","acid","."),4177651). assertion_content_comment('tOboGo_AsparagineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","asparagine",",","2-amino-3-carbamoylpropanoic","acid","."),4231754). assertion_content_comment('tOboGo_AsparagineGlutaminePermeaseActivity',s("OBSOLETE",".","Catalysis","of","the","stereospecific","transfer","of","asparagine","or","glutamine","across","a","biological","membrane","."),4296348). assertion_content_comment('tOboGo_AsparagineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","asparagine",",","2-amino-3-carbamoylpropanoic","acid","."),4042361). assertion_content_comment('tOboGo_AsparagineTransport',s("The","directed","movement","of","asparagine",",","alpha-aminosuccinamic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4228754). assertion_content_comment('tOboGo_AsparagusateReductaseActivity',s("Catalysis","of","the","reaction",":","3-mercapto-2-mercaptomethylpropanoate","+","NAD","(","+",")","=","asparagusate","+","H","(","+",")","+","NADH","."),4267067). assertion_content_comment('tOboGo_Aspartate_AlanineAntiporterActivity',s("Catalysis","of","the","reaction",":","aspartate","(","out",")","+","alanine","(","in",")","=","aspartate","(","in",")","+","alanine","(","out",")"),4178139). assertion_content_comment('tOboGo_AspartateBinding',s("Interacting","selectively","and","non-covalently","with","glutamate",",","the","anion","of","2-aminobutanedioic","acid","."),4173190). assertion_content_comment('tOboGo_AspartateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aspartate",",","the","anion","derived","from","aspartic","acid",",","2-aminobutanedioic","acid","."),4231779). assertion_content_comment('tOboGo_AspartateCarbamoyltransferaseActivity',s("Catalysis","of","the","reaction",":","L-aspartate","+","carbamoyl","phosphate","=","N-carbamoyl-L-aspartate","+","H","(","+",")","+","phosphate","."),4212665). assertion_content_comment('tOboGo_AspartateCarbamoyltransferaseComplex',s("A","multienzyme","complex","that","catalyzes","the","formation","N-carbamoyl-L-aspartate","from","carbamoyl","phosphate","and","L-aspartate",".","It","exhibits","a","variety","of","architectural","organizations",",","but","in","all","microorganisms","the","core","catalytic","component","is","a","homotrimer","of","approximately","34","kDa","polypeptides","."),4259627). assertion_content_comment('tOboGo_AspartateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","aspartate",",","the","anion","derived","from","aspartic","acid",",","2-aminobutanedioic","acid","."),4231806). assertion_content_comment('tOboGo_AspartateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-aspartate","+","H2O","+","NAD","(","P",")","+","=","oxaloacetate","+","NH3","+","NAD","(","P",")","H","+","H","+"),4342447). assertion_content_comment('tOboGo_AspartateFamilyAminoAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","amino","acids","of","the","aspartate","family",",","comprising","asparagine",",","aspartate",",","lysine",",","methionine","and","threonine","."),4042260). assertion_content_comment('tOboGo_AspartateFamilyAminoAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","amino","acids","of","the","aspartate","family",",","comprising","asparagine",",","aspartate",",","lysine",",","methionine","and","threonine","."),4177218). assertion_content_comment('tOboGo_AspartateFamilyAminoAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","amino","acids","of","the","aspartate","family",",","comprising","asparagine",",","aspartate",",","lysine",",","methionine","and","threonine","."),4042227). assertion_content_comment('tOboGo_AspartateKinaseActivity',s("Catalysis","of","the","reaction",":","L-aspartate","+","ATP","=","4-phospho-L-aspartate","+","ADP","+","H","(","+",")"),4212621). assertion_content_comment('tOboGo_AspartateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","aspartate",",","the","anion","derived","from","aspartic","acid",",","2-aminobutanedioic","acid","."),4231775). assertion_content_comment('tOboGo_AspartateOxidaseActivity',s("Catalysis","of","the","reaction",":","aspartate","+","O2","=","iminosuccinate","+","hydrogen","peroxide","."),4252363). assertion_content_comment('tOboGo_AspartateRacemaseActivity',s("Catalysis","of","the","reaction",":","L-aspartate","=","D-aspartate","."),4372828). assertion_content_comment('tOboGo_AspartateTransamidation',s("The","exchange","of","the","amino","group","of","aspartate",",","the","anion","derived","from","aspartic","acid",",","for","another","amino","group","."),4241489). assertion_content_comment('tOboGo_AspartateTransport',s("The","directed","movement","of","aspartate",",","the","anion","of","aspartic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4176434). assertion_content_comment('tOboGo_AsparticAcidMethylthiotransferaseActivity',s("Catalysis","of","the","methylthiolation","(","-SCH3","addition",")","of","the","beta-carbon","of","peptidyl-aspartic","acid","to","form","peptidyl-L-beta-methylthioaspartic","acid","."),4379322). assertion_content_comment('tOboGo_AsparticEndopeptidaseActivityIntramembraneCleaving',s("Catalysis","of","the","hydrolysis","of","nonterminal","peptide","bonds","in","a","polypeptide","chain",",","occurring","within","the","plasma","membrane","."),4313202). assertion_content_comment('tOboGo_AspartoacylaseActivity',s("Catalysis","of","the","reaction",":","N-acyl-L-aspartate","+","H2O","=","a","fatty","acid","anion","+","L-aspartate","."),4233314). assertion_content_comment('tOboGo_AspartylAminopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","an","N-terminal","aspartate","or","glutamate","from","a","peptide",",","with","a","preference","for","aspartate","."),4316709). assertion_content_comment('tOboGo_AspartylEsteraseActivity',s("Catalysis","of","the","hydrolysis","of","an","ester","bond","by","a","mechanism","involving","a","catalytically","active","aspartic","acid","residue","."),4298623). assertion_content_comment('tOboGo_AspartyltransferaseActivity',s("Catalysis","of","the","reaction",":","L-asparagine","+","H","(","+",")","+","hydroxylamine","=","beta-L-aspartylhydroxamate","+","NH","(","4",")","(","+",")"),4371842). assertion_content_comment('tOboGo_AspulvinoneDimethylallyltransferaseActivity',s("Catalysis","of","the","reaction",":","aspulvinone","E","+","2","dimethylallyl","diphosphate","=","aspulvinone","H","+","2","diphosphate","."),4371878). assertion_content_comment('tOboGo_Assemblon',s("Antigenically","dense","structures","located","at","the","periphery","of","nuclei",",","close","to","but","not","abutting","nuclear","membranes",".","Assemblons","contain","the","proteins","for","immature-capsid","assembly",";","they","are","located","at","the","periphery","of","a","diffuse","structure","composed","of","proteins","involved","in","DNA","synthesis",",","which","overlaps","only","minimally","with","the","assemblons",".","More","than","one","site","can","be","present","simultaneously","."),4357836). assertion_content_comment('tOboGo_AssemblyOfActomyosinApparatusInvolvedInCellCycleCytokinesis',s("The","assembly","and","arrangement","of","an","apparatus","composed","of","actin",",","myosin",",","and","associated","proteins","that","will","function","in","cytokinesis","."),3978682). assertion_content_comment('tOboGo_AssociativeLearning',s("Learning","by","associating","a","stimulus","(","the","cause",")","with","a","particular","outcome","(","the","effect",")"),4150488). assertion_content_comment('tOboGo_AstacinActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds","in","substrates","containing","five","or","more","amino","acids",",","preferentially","with","Ala","in","P1","'",",","and","Pro","in","P2","'"),4254932). assertion_content_comment('tOboGo_Aster',s("An","array","of","microtubules","emanating","from","a","spindle","pole","MTOC","that","do","not","connect","to","kinetochores","."),3973713). assertion_content_comment('tOboGo_ASTRAComplex',s("A","protein","complex","that","is","part","of","the","chromatin","remodeling","machinery",";","the","acronym","stands","for","ASsembly","of","Tel",",","Rvb","and","Atm-like","kinase",".","In","Saccharomyces","cerevisiae","this","complex","includes","Rvb1p",",","Rvb2p",",","Tra1p",",","Tel2p",",","Asa1p",",","Ttilp","and","Tti2p","."),4173733). assertion_content_comment('tOboGo_AstralMicrotubule',s("Any","of","the","spindle","microtubules","that","radiate","in","all","directions","from","the","spindle","poles","and","are","thought","to","contribute","to","the","forces","that","separate","the","poles","and","position","them","in","relation","to","the","rest","of","the","cell","."),3973758). assertion_content_comment('tOboGo_AstralSpindleAssemblyInvolvedInMaleMeiosis',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","astral","spindle","in","male","meiotic","cells","."),4221921). assertion_content_comment('tOboGo_AstralSpindleAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","spindle",",","the","array","of","microtubules","and","associated","molecules","that","serves","to","move","duplicated","chromosomes","apart",",","in","the","presence","of","centrosomes","."),4221862). assertion_content_comment('tOboGo_AstrocyteActivationInvolvedInImmuneResponse',s("A","change","in","the","morphology","or","behavior","of","an","astrocyte","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4378021). assertion_content_comment('tOboGo_AstrocyteActivation',s("A","change","in","morphology","and","behavior","of","an","astrocyte","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),4103538). assertion_content_comment('tOboGo_AstrocyteCellMigration',s("The","orderly","movement","of","an","astrocyte",",","a","class","of","large","neuroglial","(","macroglial",")","cells","in","the","central","nervous","system",",","the","largest","and","most","numerous","neuroglial","cells","in","the","brain","and","spinal","cord","."),4325308). assertion_content_comment('tOboGo_AstrocyteChemotaxis',s("The","directed","movement","of","an","astrocyte","guided","by","a","specific","chemical","concentration","gradient",".","Movement","may","be","towards","a","higher","concentration","(","positive","chemotaxis",")","or","towards","a","lower","concentration","(","negative","chemotaxis",")"),4142108). assertion_content_comment('tOboGo_AstrocyteDevelopment',s("The","process","aimed","at","the","progression","of","an","astrocyte","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell",".","An","astrocyte","is","the","most","abundant","type","of","glial","cell",".","Astrocytes","provide","support","for","neurons","and","regulate","the","environment","in","which","they","function","."),4036363). assertion_content_comment('tOboGo_AstrocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","astrocyte",".","An","astrocyte","is","the","most","abundant","type","of","glial","cell",".","Astrocytes","provide","support","for","neurons","and","regulate","the","environment","in","which","they","function","."),4036342). assertion_content_comment('tOboGo_AstrocyteFateCommitment',s("The","commitment","of","a","cells","to","a","specific","astrocyte","fate","and","its","restriction","to","develop","only","into","an","astrocyte","."),4047467). assertion_content_comment('tOboGo_AsymmetricCellDivision',s("The","asymmetric","division","of","cells","to","produce","two","daughter","cells","with","different","developmental","potentials",".","It","is","of","fundamental","significance","for","the","generation","of","cell","diversity","."),4017025). assertion_content_comment('tOboGo_AsymmetricGolgiRibbonFormation',s("The","asymmetric","formation","of","a","continuous","ribbon","of","interconnected","Golgi","stacks","of","flat","cisternae","that","contributes","to","the","establishment","of","epithelial","cell","polarity","."),4149320). assertion_content_comment('tOboGo_AsymmetricNeuroblastDivisionResultingInGanglionMotherCellFormation',s("Any","process","resulting","in","the","physical","partitioning","and","separation","of","a","neuroblast","into","a","neuroblast","and","a","ganglion","mother","cell","."),4221979). assertion_content_comment('tOboGo_AsymmetricNeuroblastDivision',s("The","process","resulting","in","the","physical","partitioning","and","separation","of","a","neuroblast","into","two","daughter","cells","with","different","developmental","potentials","."),4221960). assertion_content_comment('tOboGo_AsymmetricProteinLocalizationInvolvedInCellFateDetermination',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","specific","asymmetric","distribution",",","resulting","in","the","formation","of","daughter","cells","of","different","types","."),4086672). assertion_content_comment('tOboGo_AsymmetricProteinLocalization',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","a","specific","location","such","that","it","is","distributed","asymmetrically","."),3980145). assertion_content_comment('tOboGo_AsymmetricRadialGlialCellDivisionInForebrain',s("The","mitotic","cell","division","of","a","radial","glial","cell","giving","rise","to","a","radial","glial","cell","and","another","cell","type","."),4047272). assertion_content_comment('tOboGo_AsymmetricSynapse',s("A","type","of","synapse","occurring","between","an","axon","and","a","dendritic","spine","or","dendritic","shaft",".","Asymmetric","synapses",",","the","most","abundant","synapse","type","in","the","central","nervous","system",",","involve","axons","that","contain","predominantly","spherical","vesicles","and","contain","a","thickened","postsynaptic","density","."),4329841). assertion_content_comment('tOboGo_AsynchronousNeurotransmitterSecretion',s("Release","of","neurotransmitter","at","the","synapse","that","persists","for","tens","to","hundreds","of","milliseconds","after","action","potential","invasion","."),4168207). assertion_content_comment('tOboGo_ATBinding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4222496). assertion_content_comment('tOboGo_ATDNABinding',s("Interacting","selectively","and","non-covalently","with","oligo","(","A",")","and","oligo","(","T",")","tracts","of","DNA","(","AT","DNA",")"),4193529). assertion_content_comment('tOboGo_Atg12LigaseActivity',s("Catalysis","of","the","covalent","attachment","of","the","ubiquitin-like","protein","Atg12","to","other","proteins","."),4245255). assertion_content_comment('tOboGo_Atg1pSignalingComplex',s("A","protein","complex","that","contains","a","protein","kinase","and","is","required","for","the","autophagosome","formation",".","In","budding","yeast","this","complex","consists","of","the","kinase","Atg1p",",","Atg13p","and","Atg17p","."),4360317). assertion_content_comment('tOboGo_Atg8LigaseActivity',s("Catalysis","of","the","covalent","attachment","of","the","ubiquitin-like","protein","Atg8","to","substrate","molecules",";","phosphatidylethanolamine","is","a","known","substrate","."),4245296). assertion_content_comment('tOboGo_ATPAdenylyltransferaseActivity',s("Catalysis","of","the","reaction",":","ADP","+","ATP","=","phosphate","+","P","(","1",")",",","P","(","4",")","-bis","(","5","'","-adenosyl",")","tetraphosphate","."),4189748). assertion_content_comment('tOboGo_ATP_ADPAntiporterActivity',s("Catalysis","of","the","reaction",":","ATP","(","out",")","+","ADP","(","in",")","=","ATP","(","in",")","+","ADP","(","out",")"),4219216). assertion_content_comment('tOboGo_ATPADPExchange',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228637). assertion_content_comment('tOboGo_ATPaseActivatorActivity',s("Functions","to","increase","the","rate","of","ATP","hydrolysis","."),4383622). assertion_content_comment('tOboGo_ATPaseActivityCoupled',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",";","this","reaction","directly","drives","some","other","reaction",",","for","example","ion","transport","across","a","membrane","."),4168978). assertion_content_comment('tOboGo_ATPaseActivityCoupledToMovementOfSubstances',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",",","to","directly","drive","the","transport","of","a","substance","."),4168986). assertion_content_comment('tOboGo_ATPaseActivityCoupledToTransmembraneMovementOfIonsPhosphorylativeMechanism',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",",","to","directly","drive","the","transport","of","ions","across","a","membrane",".","The","reaction","is","characterized","by","the","transient","formation","of","a","high-energy","aspartyl-phosphoryl-enzyme","intermediate","."),4212938). assertion_content_comment('tOboGo_ATPaseActivityCoupledToTransmembraneMovementOfIons',s("Catalysis","of","the","transfer","of","an","ion","from","one","side","of","a","membrane","to","the","other",",","driven","by","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate","."),4185950). assertion_content_comment('tOboGo_ATPaseActivityCoupledToTransmembraneMovementOfSubstances',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",",","to","directly","drive","the","active","transport","of","a","substance","across","a","membrane","."),4168988). assertion_content_comment('tOboGo_ATPaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate","+","2","H","+","May","or","may","not","be","coupled","to","another","reaction","."),4168966). assertion_content_comment('tOboGo_ATPaseActivityUncoupled',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",";","this","reaction","is","not","directly","coupled","to","any","other","reaction","."),4316430). assertion_content_comment('tOboGo_ATPaseBinding',s("Interacting","selectively","and","non-covalently","with","an","ATPase",",","any","enzyme","that","catalyzes","the","hydrolysis","of","ATP","."),4287213). assertion_content_comment('tOboGo_ATPaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","any","enzyme","that","catalyzes","the","hydrolysis","of","ATP","to","ADP","and","orthophosphate","."),4306331). assertion_content_comment('tOboGo_ATPaseRegulatorActivity',s("Modulates","the","rate","of","ATP","hydrolysis","by","an","ATPase","."),4160779). assertion_content_comment('tOboGo_ATPBinding',s("Interacting","selectively","and","non-covalently","with","ATP",",","adenosine","5","'","-triphosphate",",","a","universally","important","coenzyme","and","enzyme","regulator","."),4218717). assertion_content_comment('tOboGo_ATPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ATP",",","adenosine","5","'","-triphosphate",",","a","universally","important","coenzyme","and","enzyme","regulator","."),4229256). 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assertion_content_comment('tOboGo_ATPDiphosphataseActivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","AMP","+","diphosphate","."),4371855). assertion_content_comment('tOboGo_ATPHydrolysisCoupledProtonTransport',s("The","transport","of","protons","against","an","electrochemical","gradient",",","using","energy","from","ATP","hydrolysis","."),4295097). assertion_content_comment('tOboGo_ATPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ATP",",","adenosine","triphosphate",",","a","universally","important","coenzyme","and","enzyme","regulator","."),4226564). assertion_content_comment('tOboGo_ATPPhosphoribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","1-","(","5-phospho-D-ribosyl",")","-ATP","+","diphosphate","=","ATP","+","5-phospho-alpha-D-ribose","1-diphosphate","."),4190169). assertion_content_comment('tOboGo_ATPSynthesisCoupledElectronTransport',s("The","transfer","of","electrons","through","a","series","of","electron","donors","and","acceptors",",","generating","energy","that","is","ultimately","used","for","synthesis","of","ATP","."),4010649). assertion_content_comment('tOboGo_ATPSynthesisCoupledProtonTransport',s("The","transport","of","protons","across","a","membrane","to","generate","an","electrochemical","gradient","(","proton-motive","force",")","that","powers","ATP","synthesis","."),4295018). assertion_content_comment('tOboGo_ATPTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","ATP",",","adenosine","triphosphate",",","from","one","side","of","a","membrane","to","the","other","."),4216384). assertion_content_comment('tOboGo_ATPTransport',s("The","directed","movement","of","ATP",",","adenosine","triphosphate",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293946). assertion_content_comment('tOboGo_AtrazineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","atrazine",",","a","triazine","ring-containing","herbicide","."),4239695). assertion_content_comment('tOboGo_AtrazineCatabolicProcessToCyanuricAcid',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","atrazine",",","a","triazine","ring-containing","herbicide",",","into","cyanuric","acid","."),4243900). assertion_content_comment('tOboGo_AtrazineCatabolicProcessToIsopropylamine',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","atrazine",",","a","triazine","ring-containing","herbicide",",","into","isopropylamine","."),4243912). assertion_content_comment('tOboGo_AtrazineCatabolicProcessToUrea',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","atrazine",",","a","triazine","ring-containing","herbicide",",","into","urea","."),4243925). assertion_content_comment('tOboGo_AtrazineChlorohydrolaseActivity',s("Catalysis","of","the","reaction",":","atrazine","+","H","(","2",")","O","=","4-","(","ethylamino",")","-2-hydroxy-6-","(","isopropylamino",")","-1",",","3",",","5-triazine","+","chloride","+","H","(","+",")"),4274251). assertion_content_comment('tOboGo_AtrazineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","atrazine",",","a","triazine","ring-containing","compound",",","widely","used","as","a","herbicide","."),4239675). assertion_content_comment('tOboGo_AtrialCardiacMuscleCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","atrial","cardiac","muscle","cell","over","time",",","from","its","formation","to","the","mature","state",".","Cardiac","muscle","cells","are","striated","muscle","cells","that","are","responsible","for","heart","contraction",".","The","atrium","is","the","part","of","the","heart","that","receives","blood","into","the","organ","."),4107656). assertion_content_comment('tOboGo_AtrialCardiacMuscleCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","cardiac","muscle","cell","in","the","atrium",".","Cardiac","muscle","cells","are","striated","muscle","cells","that","are","responsible","for","heart","contraction",".","The","atrium","is","the","part","of","the","heart","that","receives","blood","into","the","organ","."),4107644). assertion_content_comment('tOboGo_AtrialCardiacMuscleCellFateCommitment',s("The","commitment","of","cells","to","atrial","cardiac","muscle","cell","fates","and","their","capacity","to","differentiate","into","cardiac","muscle","cells","of","the","atrium",".","Cardiac","muscle","cells","are","striated","muscle","cells","that","are","responsible","for","heart","contraction","."),4114372). assertion_content_comment('tOboGo_AtrialCardiacMuscleTissueDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","cardiac","muscle","of","the","atrium","over","time",",","from","its","formation","to","the","mature","structure","."),4107546). assertion_content_comment('tOboGo_AtrialCardiacMuscleTissueMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","cardiac","atrium","muscle","is","generated","and","organized","."),4107549). assertion_content_comment('tOboGo_AtrialCardiacMyofibrilDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","atrial","cardiac","myofibril","over","time",",","from","its","formation","to","the","mature","structure",".","A","cardiac","myofibril","is","a","myofibril","specific","to","cardiac","muscle","cells","."),4107681). assertion_content_comment('tOboGo_AtrialSeptumDevelopment',s("The","progression","of","the","atrial","septum","over","time",",","from","its","initial","formation","to","the","mature","structure","."),4001540). assertion_content_comment('tOboGo_AtrialSeptumIntermediumDevelopment',s("The","progression","of","the","atrial","septum","intermedium","over","time",",","from","its","formation","to","the","mature","structure","."),4001542). assertion_content_comment('tOboGo_AtrialSeptumIntermediumMorphogenesis',s("The","process","in","which","anatomical","structure","of","an","atrial","septum","intermedium","is","generated","and","organized","."),4001601). assertion_content_comment('tOboGo_AtrialSeptumMorphogenesis',s("The","developmental","process","in","which","atrial","septum","is","generated","and","organized",".","The","atrial","septum","separates","the","upper","chambers","(","the","atria",")","of","the","heart","from","one","another","."),4001596). assertion_content_comment('tOboGo_AtrialSeptumPrimumMorphogenesis',s("The","process","in","which","anatomical","structure","of","an","atrial","septum","primum","is","generated","and","organized","."),4001649). assertion_content_comment('tOboGo_AtrialSeptumSecundumMorphogenesis',s("The","process","in","which","anatomical","structure","of","an","atrial","septum","secundum","is","generated","and","organized","."),4001620). assertion_content_comment('tOboGo_AtrialVentricularJunctionRemodeling',s("The","reorganization","or","renovation","of","heart","tissue","that","contributes","to","the","maturation","of","the","connection","between","an","atrium","and","a","ventricle","."),4001786). assertion_content_comment('tOboGo_AtrichoblastDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","atrichoblast",",","a","root","epidermal","cell","that","will","not","give","rise","to","a","root","hair","."),4032609). assertion_content_comment('tOboGo_AtrichoblastFateSpecification',s("The","process","involved","in","the","specification","of","an","atrichoblast","."),4032611). assertion_content_comment('tOboGo_AtrioventricularBundleCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","structural","and/or","functional","features","of","a","cell","of","the","atrioventricular","bundle",".","These","cells","are","specialized","cardiomyocytes","that","transmit","signals","from","the","AV","node","to","the","cardiac","Purkinje","fibers","."),4003756). assertion_content_comment('tOboGo_AtrioventricularNodeCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","atrioventricular","(","AV",")","node","cell","over","time",",","from","its","formation","to","the","mature","state","."),4114449). assertion_content_comment('tOboGo_AtrioventricularNodeCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","atrioventricular","(","AV",")","node","cell",".","AV","node","cells","are","pacemaker","cells","that","are","found","in","the","atrioventricular","node","."),4114384). assertion_content_comment('tOboGo_AtrioventricularNodeCellFateCommitment',s("The","commitment","of","cells","to","atrioventricular","(","AV",")","node","cell","fates","and","their","capacity","to","differentiate","into","AV","node","cells","."),4114460). assertion_content_comment('tOboGo_AtrioventricularNodeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","atrioventricular","(","AV",")","node","over","time",",","from","its","formation","to","the","mature","structure",".","The","AV","node","is","part","of","the","cardiac","conduction","system","that","controls","the","timing","of","ventricle","contraction","by","receiving","electrical","signals","from","the","sinoatrial","(","SA",")","node","and","relaying","them","to","the","His-Purkinje","system","."),4003778). assertion_content_comment('tOboGo_AtrioventricularNodeImpulseConductionDelay',s("A","heart","process","that","modulates","the","propagation","of","the","signal","that","causes","the","heart","muscle","to","contract","."),4134991). assertion_content_comment('tOboGo_AtrioventricularValveDevelopment',s("The","progression","of","the","atrioventricular","valve","over","time",",","from","its","formation","to","the","mature","structure","."),4002206). assertion_content_comment('tOboGo_AtrioventricularValveFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","atrioventricular","valve","from","unspecified","parts",".","This","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","discrete","structure","and","ends","when","the","structural","rudiment","is","recognizable","."),4002345). assertion_content_comment('tOboGo_AtrioventricularValveMorphogenesis',s("The","process","in","which","the","structure","of","the","atrioventricular","valve","is","generated","and","organized","."),4002217). 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assertion_content_comment('tOboGo_AttachmentOfSpindleMicrotubulesToKinetochoreInvolvedInHomologousChromosomeSegregation',s("The","process","in","which","spindle","microtubules","become","physically","associated","with","the","proteins","making","up","the","kinetochore","complex","during","meiosis","I",".","During","meiosis","I","sister","kinetochores","are","lying","next","to","each","other","facing","the","same","spindle","pole","and","monopolar","attachment","of","the","chromatid","to","the","spindle","occurs","."),4118307). assertion_content_comment('tOboGo_AttachmentOfSpindleMicrotubulesToKinetochoreInvolvedInMeioticChromosomeSegregation',s("The","cell","cycle","process","in","which","spindle","microtubules","become","physically","associated","with","the","proteins","making","up","the","kinetochore","complex","contributing","to","meiotic","chromosome","segregation","."),4118122). assertion_content_comment('tOboGo_AttachmentOfSpindleMicrotubulesToKinetochoreInvolvedInMeioticSisterChromatidSegregation',s("The","process","in","which","spindle","microtubules","become","physically","associated","with","the","proteins","making","up","the","kinetochore","complex","during","meiosis","II",".","During","meiosis","II","sister","kinetochores","are","situated","facing","opposite","spindle","poles","and","bipolar","attachment","of","the","sister","chromosomes","to","the","spindle","occurs","."),4118321). assertion_content_comment('tOboGo_AttachmentOfSpindleMicrotubulesToKinetochoreInvolvedInMitoticSisterChromatidSegregation',s("The","cell","cycle","process","in","which","spindle","microtubules","become","physically","associated","with","the","proteins","making","up","the","kinetochore","complex","during","mitosis",".","During","mitosis",",","the","kinetochores","of","sister","chromosomes","are","situated","facing","opposite","spindle","poles","and","bipolar","attachment","of","the","sister","chromosomes","to","the","spindle","occurs","."),4118135). assertion_content_comment('tOboGo_AttachmentOfSpindleMicrotubulesToKinetochore',s("The","process","in","which","spindle","microtubules","become","physically","associated","with","the","proteins","making","up","the","kinetochore","complex","."),4118107). assertion_content_comment('tOboGo_AttachmentOfSpindleMicrotubulesToMeioticChromosome',s("The","cell","cycle","process","in","which","spindle","microtubules","become","physically","associated","with","a","chromosome","during","meiosis","."),4060072). assertion_content_comment('tOboGo_AttachmentOfSpindleMicrotubulesToMitoticChromosome',s("The","cell","cycle","process","in","which","spindle","microtubules","become","physically","associated","with","a","chromosome","during","mitosis","."),4118149). assertion_content_comment('tOboGo_AttachmentOfTelomeresToNuclearEnvelope',s("The","cell","cycle","process","in","which","physical","connections","are","formed","between","telomeres","and","the","nuclear","envelope",",","facilitating","bouquet","formation","."),4137393). assertion_content_comment('tOboGo_AttachmentOfTelomeresToSpindlePoleBody',s("The","cell","cycle","process","in","which","physical","connections","are","formed","between","telomeres","and","the","spindle","pole","body",",","facilitating","bouquet","formation","."),4054959). assertion_content_comment('tOboGo_AttachmentOrganelleMembrane',s("The","lipid","bilayer","surrounding","an","attachment","organelle","."),4065808). assertion_content_comment('tOboGo_AttachmentOrganelle',s("A","membrane-bounded","extension","of","the","cell",",","originally","characterized","in","Mycoplasma","species",",","that","contains","an","electron-dense","core","that","is","part","of","the","cytoskeleton","and","is","oriented","lengthwise","and","ends","distally","in","a","bulbous","knob","(","terminal","button",")","Required","for","adherence","to","host","cells","and","involved","in","gliding","motility","and","cell","division","."),4065797). assertion_content_comment('tOboGo_AuditoryBehavior',s("The","actions","or","reactions","of","an","organism","in","response","to","a","sound","."),4314070). assertion_content_comment('tOboGo_AuditoryReceptorCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","auditory","receptor","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","specific","fate","."),3992809). assertion_content_comment('tOboGo_AuditoryReceptorCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","auditory","hair","cell","."),3992806). assertion_content_comment('tOboGo_AuditoryReceptorCellFateCommitment',s("The","process","in","which","the","cellular","identity","of","auditory","hair","cells","is","acquired","and","determined","."),4021555). assertion_content_comment('tOboGo_AuditoryReceptorCellFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","auditory","hair","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4078189). assertion_content_comment('tOboGo_AuditoryReceptorCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","auditory","hair","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4033425). assertion_content_comment('tOboGo_AuditoryReceptorCellMorphogenesis',s("Any","process","that","alters","the","size","or","shape","of","an","auditory","receptor","cell","."),3992812). assertion_content_comment('tOboGo_AuditoryReceptorCellStereociliumOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","stereocilium",".","A","stereocilium","is","an","actin-based","protrusion","from","the","apical","surface","of","auditory","hair","cells","."),4108695). assertion_content_comment('tOboGo_AureusidinSynthaseActivity',s("Catalysis","of","the","reactions",":","2","'",",","4",",","4","'",",","6","'","-tetrahydroxychalcone","+","O2","=","aureusidin","+","H2O",",","and","2","'",",","3",",","4",",","4","'",",","6","'","-pentahydroxychalcone","+","1/2","O2","=","aureusidin","+","H2O","."),4342301). assertion_content_comment('tOboGo_AuroneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","aurones",",","a","series","of","yellow","plant","pigments","."),4283805). 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assertion_content_comment('tOboGo_Autolysis',s("The","spontaneous","death","by","lysis","of","bacteria","in","response","to","environmental","conditions","."),4384453). assertion_content_comment('tOboGo_AutonomicNervousSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","autonomic","nervous","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","autonomic","nervous","system","is","composed","of","neurons","that","are","not","under","conscious","control",",","and","is","comprised","of","two","antagonistic","components",",","the","sympathetic","and","parasympathetic","nervous","systems",".","The","autonomic","nervous","system","regulates","key","functions","including","the","activity","of","the","cardiac","(","heart",")","muscle",",","smooth","muscles","(","e.g",".","of","the","gut",")",",","and","glands","."),4043913). assertion_content_comment('tOboGo_AutophagicCellDeath',s("A","form","of","programmed","cell","death","that","is","accompanied","by","macroautophagy",",","which","is","characterized","by","the","sequestration","of","cytoplasmic","material","within","autophagosomes","for","bulk","degradation","by","lysosomes",".","Autophagic","cell","death","is","characterized","by","lack","of","chromatin","condensation",",","massive","vacuolization","of","the","cytoplasm",",","and","accumulation","of","(","double-membraned",")","autophagic","vacuoles",",","with","little","or","no","uptake","by","phagocytic","cells","."),4072953). assertion_content_comment('tOboGo_AutophagicDeathSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310450). 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assertion_content_comment('tOboGo_AuxinEffluxCarrierComplex',s("The","protein","complex","associated","with","the","plasma","membrane","of","certain","plant","cells","(","e.g",".","root","cortex",",","epidermal","cells",")","that","functions","to","transport","auxin","out","of","the","cell","."),4261841). assertion_content_comment('tOboGo_AuxinEfflux',s("The","process","involved","in","the","transport","of","auxin","out","of","the","cell","."),4030626). assertion_content_comment('tOboGo_AuxinEffluxTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","auxin",",","from","one","side","of","a","membrane","to","the","other",",","out","of","a","cell","."),4332520). 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assertion_content_comment('tOboGo_AuxinInfluxTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","auxin",",","from","one","side","of","a","membrane","to","the","other",",","into","a","cell","."),4332531). assertion_content_comment('tOboGo_AuxinMediatedSignalingPathwayInvolvedInPhyllotacticPatterning',s("The","series","of","molecular","signals","generated","in","response","to","detection","of","auxin","that","contributes","to","the","radial","pattern","formation","process","resulting","in","the","formation","of","leaf","or","flower","primordia","around","the","center","of","a","shoot","apical","meristem","."),4110937). assertion_content_comment('tOboGo_AuxinMediatedSignalingPathway',s("The","series","of","molecular","signals","generated","in","response","to","detection","of","auxin","."),4030606). 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assertion_content_comment('tOboGo_AvoidanceOfDefensesOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process",",","either","constitutive","or","induced",",","by","which","an","organism","evades",",","minimizes",",","or","suppresses","the","effects","of","a","second","organism","'","s","defense","(","s",")",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4079945). assertion_content_comment('tOboGo_AvoidanceOfHostDefenses',s("Any","process",",","either","constitutive","or","induced",",","by","which","an","organism","evades",",","suppresses","or","tolerates","the","effects","of","its","host","organism","'","s","defense","(","s",")","Host","defenses","may","be","induced","by","the","presence","of","the","organism","or","may","be","preformed","(","e.g",".","physical","barriers",")","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080757). assertion_content_comment('tOboGo_AvoidanceOfSymbiontDefenses',s("Any","process",",","either","constitutive","or","induced",",","by","which","an","organism","evades",",","minimizes",",","or","suppresses","the","effects","of","its","symbiont","organism","'","s","defense","(","s",")","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197205). assertion_content_comment('tOboGo_AxialCellularBudSiteSelection',s("The","process","of","defining","the","next","site","of","bud","emergence","adjacent","to","the","last","site","of","bud","emergence","on","a","budding","cell","."),4236147). assertion_content_comment('tOboGo_AxialMesodermalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","axial","mesoderm","cell","."),4102816). assertion_content_comment('tOboGo_AxialMesodermalCellFateCommitment',s("The","process","in","which","a","cell","becomes","committed","to","become","an","axial","mesoderm","cell","."),4102819). assertion_content_comment('tOboGo_AxialMesodermalCellFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","axial","mesoderm","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4102885). assertion_content_comment('tOboGo_AxialMesodermalCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","axial","mesoderm","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4102822). assertion_content_comment('tOboGo_AxialMesodermDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","axial","mesoderm","over","time",",","from","its","formation","to","the","mature","structure",".","The","axial","mesoderm","includes","the","prechordal","mesoderm","and","the","chordamesoderm",".","It","gives","rise","to","the","prechordal","plate","and","to","the","notochord","."),4102810). assertion_content_comment('tOboGo_AxialMesodermFormation',s("The","process","that","gives","rise","to","the","axial","mesoderm",".","This","process","pertains","to","the","initial","formation","of","the","structure","from","unspecified","parts","."),4102814). assertion_content_comment('tOboGo_AxialMesodermMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","axial","mesoderm","are","generated","and","organized","."),4102812). assertion_content_comment('tOboGo_AxialMesodermStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","axial","mesoderm",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4102859). assertion_content_comment('tOboGo_AxisElongationInvolvedInSomitogenesis',s("The","developmental","growth","that","results","in","the","elongation","of","the","rostral-caudal","axis","that","contributes","to","somitogenesis","."),4151513). assertion_content_comment('tOboGo_AxisElongation',s("The","developmental","growth","that","results","in","the","elongation","of","a","line","that","defines","polarity","or","symmetry","in","an","anatomical","structure","."),4004607). assertion_content_comment('tOboGo_AxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","a","pattern","along","a","line","or","around","a","point","."),4004518). assertion_content_comment('tOboGo_Axolemma',s("The","portion","of","the","plasma","membrane","surrounding","an","axon",";","it","is","a","specialized","trilaminar","random","mosaic","of","protein","molecules","floating","within","a","fluid","matrix","of","highly","mobile","phospholipid","molecules",",","7-8","nm","in","thickness","."),4051622). assertion_content_comment('tOboGo_AxonalDefasciculation',s("Separation","of","axons","away","from","a","bundle","of","axons","known","as","a","fascicle","."),4017290). assertion_content_comment('tOboGo_AxonalFasciculation',s("The","collection","of","axons","into","a","bundle","of","rods",",","known","as","a","fascicle","."),4017279). assertion_content_comment('tOboGo_AxonalGrowthCone',s("The","migrating","motile","tip","of","a","growing","nerve","cell","axon","."),4288100). assertion_content_comment('tOboGo_AxonalSpine',s("A","spine","that","originates","from","the","axon",",","usually","from","the","initial","segment","."),4287882). 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assertion_content_comment('tOboGo_AxonemalDyneinComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","axonemal","dynein","complex",",","a","dynein","complex","found","in","eukaryotic","cilia","and","flagella",",","in","which","the","motor","domain","heads","interact","with","adjacent","microtubules","to","generate","a","sliding","force","which","is","converted","to","a","bending","motion","."),4174122). assertion_content_comment('tOboGo_AxonemalDyneinComplex',s("A","dynein","complex","found","in","eukaryotic","cilia","and","flagella",";","the","motor","domain","heads","interact","with","adjacent","microtubules","to","generate","a","sliding","force","which","is","converted","to","a","bending","motion",".","May","contain","two","or","three","dynein","heavy","chains","as","well","as","several","light","chains","."),4221612). assertion_content_comment('tOboGo_AxonemalDyneinHeavyChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383731). assertion_content_comment('tOboGo_AxonemalDyneinIntermediateChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383698). assertion_content_comment('tOboGo_AxonemalDyneinIntermediateLightChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383709). assertion_content_comment('tOboGo_AxonemalDyneinLightChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383676). assertion_content_comment('tOboGo_AxonemalMicrotubuleDepolymerization',s("The","removal","of","tubulin","heterodimers","from","one","or","both","ends","of","an","axonemal","microtubule",".","An","axonemal","microtubule","is","a","microtubule","in","the","axoneme","of","a","cilium","or","flagellum",";","an","axoneme","contains","nine","modified","doublet","microtubules","surrounding","a","pair","of","single","microtubules","."),4013329). assertion_content_comment('tOboGo_AxonemalMicrotubule',s("A","microtubule","in","the","axoneme","of","a","cilium","or","flagellum",";","an","axoneme","contains","nine","modified","doublet","microtubules","surrounding","a","pair","of","single","microtubules","."),4221557). assertion_content_comment('tOboGo_AxonemalMotorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193087). 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assertion_content_comment('tOboGo_AxonExtensionInvolvedInDevelopment',s("Long","distance","growth","of","a","single","axon","process","involved","in","cellular","development","."),4107041). assertion_content_comment('tOboGo_AxonExtensionInvolvedInRegeneration',s("Long","distance","growth","of","a","single","axon","process","involved","in","regeneration","of","the","neuron","."),4107044). assertion_content_comment('tOboGo_AxonExtension',s("Long","distance","growth","of","a","single","process","."),4046540). assertion_content_comment('tOboGo_AxonGuidanceReceptorActivity',s("Combining","with","an","extracellular","messenger","that","results","in","a","change","in","cellular","activity","involved","in","axon","guidance","."),4246898). 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assertion_content_comment('tOboGo_AzoleTransporterActivity',s("Enables","the","directed","movement","of","azoles",",","heterocyclic","compound","found","in","many","biologically","important","substances",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4292928). assertion_content_comment('tOboGo_AzoleTransport',s("The","directed","movement","of","azoles",",","heterocyclic","compounds","found","in","many","biologically","important","substances",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4294124). assertion_content_comment('tOboGo_Azurin',s("OBSOLETE",".","Brilliant","blue","copper-containing","protein","of","low","molecular","weight","found","in","some","bacteria",";","thought","to","transfer","electrons","to","cytochrome","oxidase",".","This","definition","includes","pseudoazurin","."),4296649). assertion_content_comment('tOboGo_AzurophilGranuleLumen',s("The","volume","enclosed","by","the","membrane","of","an","azurophil","granule",",","a","primary","lysosomal","granule","found","in","neutrophil","granulocytes","that","contains","a","wide","range","of","hydrolytic","enzymes","and","is","released","into","the","extracellular","fluid","."),4082357). assertion_content_comment('tOboGo_AzurophilGranuleMembrane',s("The","lipid","bilayer","surrounding","an","azurophil","granule",",","a","primary","lysosomal","granule","found","in","neutrophil","granulocytes","that","contains","a","wide","range","of","hydrolytic","enzymes","and","is","released","into","the","extracellular","fluid","."),4082412). assertion_content_comment('tOboGo_AzurophilGranule',s("Primary","lysosomal","granule","found","in","neutrophil","granulocytes",".","Contains","a","wide","range","of","hydrolytic","enzymes","and","is","released","into","the","extracellular","fluid","."),4082345). assertion_content_comment('tOboGo_B1BradykininReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","B1","bradykinin","receptor","."),4323198). assertion_content_comment('tOboGo_B2BradykininReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","B2","bradykinin","receptor","."),4323178). assertion_content_comment('tOboGo_B875AntennaComplex',s("Protein","complex","that","surrounds","and","transfers","excitation","energy","directly","to","the","bacterial","reaction","center",";","binds","bacteriochlorophyll","a","and","has","a","single","absorption","band","between","870","and","890","nm","."),4052922). assertion_content_comment('tOboGo_BacillithiolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","bacillithiol",",","the","alpha-anomeric","glycoside","of","L-cysteinyl-D-glucosamine","with","L-malic","acid",".","Bacillithiol",",","produced","widely","in","the","Firmicutes","and","sporadically","in","other","bacterial","lineages",",","is","a","low-molecular-weight","thiol","analogous","to","mycothiol","in","the","Actinomycetes","and","glutathione","in","many","species","."),4169366). assertion_content_comment('tOboGo_BacillithiolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","bacillithiol",",","the","alpha-anomeric","glycoside","of","L-cysteinyl-D-glucosamine","with","L-malic","acid",".","Bacillithiol",",","produced","widely","in","the","Firmicutes","and","sporadically","in","other","bacterial","lineages",",","is","a","low-molecular-weight","thiol","analogous","to","mycothiol","in","the","Actinomycetes","and","glutathione","in","many","species","."),4169256). assertion_content_comment('tOboGo_BacillusSubtilisRibonucleaseActivity',s("Catalysis","of","the","endonucleolytic","cleavage","to","2","'",",","3","'","-cyclic","nucleotides","."),4343949). assertion_content_comment('tOboGo_BackwardLocomotion',s("Posterior","movement","of","an","organism",",","e.g",".","following","the","direction","of","the","tail","of","an","animal","."),4094289). assertion_content_comment('tOboGo_BacterialCellSurfaceBinding',s("Interacting","selectively","and","non-covalently","with","any","component","on","the","surface","of","a","bacterial","cell","."),4285259). assertion_content_comment('tOboGo_BacterialNucleoid',s("The","region","of","a","bacterial","cell","to","which","the","DNA","is","confined","."),4325631). assertion_content_comment('tOboGo_BacteriochlorophyllBinding',s("Interacting","selectively","and","non-covalently","with","bacteriochlorophyll",",","a","form","of","chlorophyll","found","in","photosynthetic","bacteria",",","such","as","the","purple","and","green","bacteria",".","There","are","several","types",",","designated","a","to","g",".","Bacteriochlorophyll","a","and","bacteriochlorophyll","b","are","structurally","similar","to","the","chlorophyll","a","and","chlorophyll","b","found","in","plants","."),4304143). assertion_content_comment('tOboGo_BacteriochlorophyllBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","bacteriochlorophyll",",","any","of","the","chlorophylls","of","photosynthetic","bacteria",".","They","differ","structurally","from","the","chlorophylls","of","higher","plants","."),4310306). assertion_content_comment('tOboGo_BacteriochlorophyllCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","bacteriochlorophyll",",","any","of","the","chlorophylls","of","photosynthetic","bacteria",".","They","differ","structurally","from","the","chlorophylls","of","higher","plants","."),4310281). assertion_content_comment('tOboGo_BacteriochlorophyllCBinding',s("Interacting","selectively","and","non-covalently","with","bacteriochlorophyll","c",",","a","chlorophyll","of","photosynthetic","bacteria",",","for","example","green","sulfur","bacteria","."),4304145). assertion_content_comment('tOboGo_BacteriochlorophyllMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","bacteriochlorophyll",",","any","of","the","chlorophylls","of","photosynthetic","bacteria",".","They","differ","structurally","from","the","chlorophylls","of","higher","plants","."),4310278). assertion_content_comment('tOboGo_BacteriocinActivity',s("OBSOLETE",".","Polypeptide","antibiotic","secreted","by","bacteria","and","able","to","kill","bacteria","of","susceptible","strains","after","absorption","by","specific","cell","surface","receptor","."),4292404). assertion_content_comment('tOboGo_BacteriocinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","bacteriocin",",","any","of","a","heterogeneous","group","of","polypeptide","antibiotics","that","are","secreted","by","certain","bacterial","strains","and","are","able","to","kill","cells","of","other","susceptible","(","frequently","related",")","strains","after","adsorption","at","specific","receptors","on","the","cell","surface",".","They","include","the","colicins",",","and","their","mechanisms","of","action","vary","."),4311101). assertion_content_comment('tOboGo_BacteriocinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","bacteriocin",",","any","of","a","heterogeneous","group","of","polypeptide","antibiotics","that","are","secreted","by","certain","bacterial","strains","and","are","able","to","kill","cells","of","other","susceptible","(","frequently","related",")","strains","after","adsorption","at","specific","receptors","on","the","cell","surface",".","They","include","the","colicins",",","and","their","mechanisms","of","action","vary","."),4354204). assertion_content_comment('tOboGo_BacteriocinImmunity',s("A","process","that","mediates","resistance","to","a","bacteriocin",":","any","of","a","heterogeneous","group","of","polypeptide","antibiotics","that","are","secreted","by","certain","bacterial","strains","and","are","able","to","kill","cells","of","other","susceptible","(","frequently","related",")","strains","after","adsorption","at","specific","receptors","on","the","cell","surface",".","They","include","the","colicins",",","and","their","mechanisms","of","action","vary","."),4311115). assertion_content_comment('tOboGo_BacteriocinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","bacteriocins",",","any","of","a","heterogeneous","group","of","polypeptide","antibiotics","that","are","secreted","by","certain","bacterial","strains","and","are","able","to","kill","cells","of","other","susceptible","(","frequently","related",")","strains","after","adsorption","at","specific","receptors","on","the","cell","surface",".","They","include","the","colicins",",","and","their","mechanisms","of","action","vary","."),4311098). assertion_content_comment('tOboGo_BacteriocinSusceptibilityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4233991). assertion_content_comment('tOboGo_BacteriocinTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","bacteriocin","from","one","side","of","the","membrane","to","the","other","."),4315849). assertion_content_comment('tOboGo_BacteriocinTransport',s("The","directed","movement","of","a","bacteriocin","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Bacteriocins","are","a","group","of","antibiotics","produced","by","bacteria","and","are","encoded","by","a","group","of","naturally","occurring","plasmids",",","e.g",".","Col","E1",".","Bacteriocins","are","toxic","to","bacteria","closely","related","to","the","bacteriocin","producing","strain","."),4315879). assertion_content_comment('tOboGo_BacteriolyticToxinActivity',s("OBSOLETE",".","Acts","as","to","cause","lysis","of","bacterial","cells","."),4290497). assertion_content_comment('tOboGo_BarbituraseActivity',s("Catalysis","of","the","reaction",":","barbiturate","+","H2O","=","malonate","+","urea","."),4371868). assertion_content_comment('tOboGo_BaroreceptorDetectionOfArterialStretch',s("The","series","of","events","by","which","the","change","in","diameter","of","an","artery","is","detected","and","converted","to","a","molecular","signal","."),3987357). assertion_content_comment('tOboGo_BaroreceptorDetectionOfDecreasedArterialStretch',s("The","series","of","events","by","which","a","decrease","in","diameter","of","an","artery","is","detected","and","converted","to","a","molecular","signal","."),3998838). assertion_content_comment('tOboGo_BaroreceptorDetectionOfIncreasedArterialStretch',s("The","series","of","events","by","which","an","increase","in","diameter","of","an","artery","is","detected","and","converted","to","a","molecular","signal","."),3998828). assertion_content_comment('tOboGo_BaroreceptorResponseToDecreasedSystemicArterialBloodPressure',s("The","lowering","of","the","number","of","nerve","impulses","from","baroreceptors","as","a","result","of","decreased","stretch","of","an","artery","that","results","in","an","increased","in","sympathetic","nerve","impulses","to","peripheral","blood","vessels","."),3991372). assertion_content_comment('tOboGo_BaroreceptorResponseToIncreasedSystemicArterialBloodPressure',s("The","increase","in","nerve","impulses","from","baroreceptors","as","a","result","of","increased","pressure","on","an","artery","that","results","in","an","inhibition","of","sympathetic","nerve","impulses","to","peripheral","blood","vessels","."),3987390). assertion_content_comment('tOboGo_BarrBody',s("A","structure","found","in","a","female","mammalian","cell","containing","an","unpaired","X","chromosome","that","has","become","densely","heterochromatic",",","silenced","and","localized","at","the","nuclear","periphery","."),4383254). assertion_content_comment('tOboGo_BarrierpepsinActivity',s("OBSOLETE",".","Catalysis","of","the","selected","cleavage","of","the","Leu6-Lys7","bond","in","the","pheromone","alpha-mating","factor","."),4210456). assertion_content_comment('tOboGo_BarrierSeptumFormationInvolvedInCellCycleCytokinesis',s("A","barrier","septum","formation","process","that","occurs","during",",","and","contributes","to",",","cytokinesis","that","occurs","in","the","context","of","cell","cycle","progression","."),4125856). assertion_content_comment('tOboGo_BarrierSeptumFormation',s("The","assembly","and","arrangement","of","a","septum","that","spans","the","plasma","membrane","interface","between","progeny","cells","following","cytokinesis",".","The","progeny","cells","that","form","a","barrier","septum","are","not","able","to","exchange","intracellular","material","."),3978586). assertion_content_comment('tOboGo_BarrierSeptum',s("A","septum","which","spans","a","cell","and","does","not","allow","exchange","of","organelles","or","cytoplasm","between","compartments","."),4363205). assertion_content_comment('tOboGo_BarrierSeptumSiteSelection',s("The","process","of","marking","the","site","where","a","barrier","septum","will","form","."),3978601). assertion_content_comment('tOboGo_BaruolSynthaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2",",","3-epoxysqualene","=","baruol",".","Baruol","is","also","known","as","D",":","B-Friedo-Baccharan-5",",","21-dien-3-ol","."),4182154). assertion_content_comment('tOboGo_BasalCortex',s("The","region","that","lies","just","beneath","the","plasma","membrane","on","the","basal","edge","of","a","cell","."),4086113). assertion_content_comment('tOboGo_BasalLabyrinth',s("A","region","in","the","lower","half","of","some","cells","formed","from","extensive","infoldings","of","the","basal","plasma","membrane",";","includes","cytoplasm","adjacent","to","the","infolded","membrane","."),4063062). assertion_content_comment('tOboGo_BasalLaminaDisassemblyInvolvedInSemicircularCanalFusion',s("A","process","that","results","in","the","breakdown","of","the","basal","lamina","that","contributes","to","the","process","of","semicircular","canal","fusion","."),4113993). assertion_content_comment('tOboGo_BasalLaminaDisassembly',s("A","process","that","results","in","the","breakdown","of","the","basal","lamina","."),4113990). assertion_content_comment('tOboGo_BasalLamina',s("A","thin","sheet","of","proteoglycans","and","glycoproteins",",","especially","laminin",",","secreted","by","cells","as","an","extracellular","matrix","."),4006845). assertion_content_comment('tOboGo_BasalPartOfCell',s("The","region","of","a","cell","situated","near","the","base",".","For","example",",","in","a","polarized","epithelial","cell",",","the","basal","surface","rests","on","the","basal","lamina","that","separates","the","epithelium","from","other","tissue","."),4021514). assertion_content_comment('tOboGo_BasalPlasmaMembrane',s("The","region","of","the","plasma","membrane","located","at","the","basal","end","of","the","cell",".","Often","used","in","reference","to","animal","polarized","epithelial","membranes",",","where","the","basal","membrane","is","the","part","attached","to","the","extracellular","matrix",",","or","in","plant","cells",",","where","the","basal","membrane","is","defined","with","respect","to","the","zygotic","axis","."),4021534). assertion_content_comment('tOboGo_BasalPoleOfNeuron',s("Portion","of","a","neuron","cell","soma","closest","to","the","point","where","the","basilar","dendrite","emerges","."),4098066). assertion_content_comment('tOboGo_BasalProteinLocalization',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","in",",","basal","regions","of","the","cell","."),4300228). assertion_content_comment('tOboGo_BasalRingOfApicalComplex',s("An","electron","dense","ring","at","the","most","posterior","position","of","the","apical","complex",",","from","which","the","subpellicular","microtubules","originate",";","formed","during","an","invasive","life","cycle","stage","of","an","apicomplexan","parasite","."),4041695). assertion_content_comment('tOboGo_BasalRNAPolymeraseIITranscriptionMachineryBinding',s("Interacting","selectively","and","non-covalently","with","the","basal","transcription","machinery","for","RNA","polymerase","II","which","is","composed","of","the","RNA","polymerase","II","core","enzyme",",","a","multisubunit","eukaryotic","nuclear","RNA","polymerase","typically","composed","of","twelve","subunits",",","and","the","basal","RNA","polymerase","II","transcription","factors",",","the","minimal","set","of","factors","required","for","formation","of","the","preinitiation","complex","(","PIC",")","by","the","RNA","polymerase","."),4355486). assertion_content_comment('tOboGo_BasalTranscriptionMachineryBinding',s("Interacting","selectively","and","non-covalently","with","the","basal","transcription","machinery","which","is","composed","of","the","RNA","polymerase","core","enzyme","and","the","basal","transcription","factor","(","s",")",",","the","minimal","set","of","factors","required","for","formation","of","the","preinitiation","complex","(","PIC",")","by","the","RNA","polymerase","."),4355484). assertion_content_comment('tOboGo_BasalTranscriptionRepressorActivity',s("Any","transcription","regulator","activity","that","prevents","or","downregulates","basal","transcription",".","Basal","transcription","results","from","transcription","that","is","controlled","by","the","minimal","complement","of","proteins","necessary","to","reconstitute","transcription","from","a","minimal","promoter","."),4257888). assertion_content_comment('tOboGo_BaseConversionOrSubstitutionEditing',s("Any","base","modification","or","substitution","events","that","result","in","alterations","in","the","coding","potential","or","structural","properties","of","RNAs","as","a","result","of","changes","in","the","base-pairing","properties","of","the","modified","ribonucleoside","(","s",")"),4224155). assertion_content_comment('tOboGo_BaseJMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","base","J","(","beta-D-glucosyl-hydroxymethyluracil",")",",","a","hypermodified","thymidine","residue","found","in","the","genome","of","kinetoplastid","parasites",".","This","modified","base","is","localized","primarily","to","repetitive","DNA",",","namely","the","telomeres",",","and","is","implicated","in","the","regulation","of","antigenic","variation",".","The","base","is","synthesized","in","a","two-step","pathway",".","Initially",",","a","thymidine","residue","in","DNA","is","hydroxylated","by","a","thymidine","hydroxylase","(","TH",")","to","form","the","intermediate","hydroxymethyluracil",",","which","is","then","glucosylated","to","form","base","J","."),4175083). assertion_content_comment('tOboGo_BasementMembraneAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","basement","membrane",",","a","part","of","the","extracellular","region","that","consists","of","a","thin","layer","of","dense","material","found","in","various","animal","tissues","interposed","between","the","cells","and","the","adjacent","connective","tissue","."),4178902). assertion_content_comment('tOboGo_BasementMembraneDisassembly',s("The","controlled","breakdown","of","the","basement","membrane","in","the","context","of","a","normal","process","such","as","imaginal","disc","eversion","."),4349335). assertion_content_comment('tOboGo_BasementMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","basement","membrane","."),4170226). assertion_content_comment('tOboGo_BasementMembrane',s("A","thin","layer","of","dense","material","found","in","various","animal","tissues","interposed","between","the","cells","and","the","adjacent","connective","tissue",".","It","consists","of","the","basal","lamina","plus","an","associated","layer","of","reticulin","fibers","."),4006835). assertion_content_comment('tOboGo_BasePairing',s("Interacting","selectively","and","non-covalently","with","nucleic","acid","via","hydrogen","bonds","between","the","bases","of","a","gene","product","molecule","and","the","bases","of","a","target","nucleic","acid","molecule","."),3975008). assertion_content_comment('tOboGo_BasePairingWithDNA',s("Interacting","selectively","and","non-covalently","with","nucleic","acid","via","hydrogen","bonds","between","the","bases","of","a","gene","product","molecule","and","the","bases","of","a","target","DNA","molecule","."),3975026). assertion_content_comment('tOboGo_BasePairingWithMRNA',s("Interacting","selectively","and","non-covalently","with","messenger","ribonucleic","acid","(","mRNA",")","via","hydrogen","bonds","between","the","bases","of","a","gene","product","molecule","and","the","bases","of","a","target","mRNA","molecule","."),4218343). assertion_content_comment('tOboGo_BasePairingWithRNA',s("Interacting","selectively","and","non-covalently","with","ribonucleic","acid","(","RNA",")","via","hydrogen","bonds","between","the","bases","of","a","gene","product","molecule","and","the","bases","of","a","target","RNA","molecule","."),4218341). assertion_content_comment('tOboGo_BasePairingWithRRNA',s("Interacting","selectively","and","non-covalently","with","ribosomal","ribonucleic","acid","(","rRNA",")","via","hydrogen","bonds","between","the","bases","of","a","gene","product","molecule","and","the","bases","of","a","target","rRNA","molecule","."),4310562). assertion_content_comment('tOboGo_BasePairingWithSnRNA',s("Interacting","selectively","and","non-covalently","with","small","nuclear","ribonucleic","acid","(","snRNA",")","via","hydrogen","bonds","between","the","bases","of","a","gene","product","molecule","and","the","bases","of","a","target","snRNA","molecule","."),4310596). assertion_content_comment('tOboGo_BasePairingWithTRNA',s("Interacting","selectively","and","non-covalently","with","transfer","ribonucleic","acid","(","mRNA",")","via","hydrogen","bonds","between","the","bases","of","a","gene","product","molecule","and","the","bases","of","a","target","tRNA","molecule","."),4310509). assertion_content_comment('tOboGo_BasicAminoAcidExportFromVacuole',s("The","directed","movement","of","basic","amino","acids","out","of","the","vacuole","."),4357557). assertion_content_comment('tOboGo_BasicAminoAcidImportIntoVacuole',s("The","directed","movement","of","basic","amino","acids","into","the","vacuole","."),4357431). assertion_content_comment('tOboGo_BasicAminoAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","basic","amino","acids","from","one","side","of","a","membrane","to","the","other",".","Acidic","amino","acids","have","a","pH","above","7","."),4215573). assertion_content_comment('tOboGo_BasicAminoAcidTransport',s("The","directed","movement","of","basic","amino","acids",",","amino","acids","with","a","pH","above","7",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4025860). assertion_content_comment('tOboGo_BasicNeutralKeratin',s("OBSOLETE",".","A","type","of","intermediate","filament","."),4301120). assertion_content_comment('tOboGo_BasidiosporeFormation',s("The","process","in","which","spores","form","outside","a","specialized","end","cell","known","as","a","basidium",".","Basidia","are","characteristic","of","the","basidiomycete","fungi","(","phylum","Basidiomycota",")",",","and","give","rise","to","spores","that","each","contain","a","haploid","nucleus","that","is","the","product","of","meiosis",".","The","spores","are","usually","attached","to","the","basidium","by","short","spikes","called","sterigmata","(","singular",":","sterigma",")","In","most","basidiomycetes","there","are","four","sterigmata","(","and","four","spores",")","to","a","basidium","."),4148093). 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assertion_content_comment('tOboGo_BCellAntigenProcessingAndPresentationFollowingPinocytosis',s("B","cell","antigen","processing","and","presentation","which","is","initiated","by","uptake","of","antigen","via","pinocytosis","."),4381437). assertion_content_comment('tOboGo_BCellAntigenProcessingAndPresentationMediatedByBCellReceptorUptakeOfAntigen',s("B","cell","antigen","processing","and","presentation","which","is","initiated","by","uptake","of","antigen","bound","to","the","B","cell","receptor","."),4381468). assertion_content_comment('tOboGo_BCellAntigenProcessingAndPresentation',s("The","process","in","which","a","B","cell","expresses","antigen","(","peptide","or","lipid",")","on","its","cell","surface","in","association","with","an","MHC","protein","complex","."),3993644). assertion_content_comment('tOboGo_BCellApoptosis',s("The","process","of","apoptosis","in","B","cells","."),3993762). assertion_content_comment('tOboGo_BCellChemotaxisAcrossHighEndothelialVenule',s("The","movement","of","a","B","cell","to","cross","a","high","endothelial","venule","in","response","to","an","external","stimulus","."),4381175). assertion_content_comment('tOboGo_BCellChemotaxis',s("The","directed","movement","of","a","B","cell","guided","by","a","specific","chemical","concentration","gradient",".","Movement","may","be","towards","a","higher","concentration","(","positive","chemotaxis",")","or","towards","a","lower","concentration","(","negative","chemotaxis",")"),4144934). assertion_content_comment('tOboGo_BCellCostimulation',s("The","process","of","providing",",","via","surface-bound","receptor-ligand","pairs",",","a","second",",","antigen-independent",",","signal","in","addition","to","that","provided","by","the","B","cell","receptor","to","augment","B","cell","activation","."),4320123). assertion_content_comment('tOboGo_BCellCytokineProduction',s("Any","process","that","contributes","to","cytokine","production","by","a","B","cell","."),3998479). assertion_content_comment('tOboGo_BCellDeletion',s("The","apoptotic","death","of","B","cells","which","is","part","of","B","cell","tolerance","induction","."),3993784). assertion_content_comment('tOboGo_BCellDifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","B","cell",".","A","B","cell","is","a","lymphocyte","of","B","lineage","with","the","phenotype","CD19-positive","and","capable","of","B","cell","mediated","immunity","."),3989002). assertion_content_comment('tOboGo_BCellHomeostasis',s("The","process","of","regulating","the","proliferation","and","elimination","of","B","cells","such","that","the","total","number","of","B","cells","within","a","whole","or","part","of","an","organism","is","stable","over","time","in","the","absence","of","an","outside","stimulus","."),3999466). assertion_content_comment('tOboGo_BCellHomeostaticProliferation',s("The","non-specific","expansion","of","B","cell","populations","within","a","whole","or","part","of","an","organism","to","reach","to","a","total","number","of","B","cells","which","will","then","remain","stable","over","time","in","the","absence","of","an","external","stimulus","."),4379517). assertion_content_comment('tOboGo_BCellInhibitorySignalingPathway',s("A","series","of","molecular","signals","initiated","by","the","binding","of","an","extracellular","ligand","to","a","receptor","on","the","surface","of","a","B","cell","capable","of","inhibiting","an","immune","effector","process","contributing","to","an","immune","response","."),4382429). assertion_content_comment('tOboGo_BCellLineageCommitment',s("The","process","in","which","a","lymphoid","progenitor","cell","becomes","committed","to","become","any","type","of","B","cell","."),3993993). assertion_content_comment('tOboGo_BCellMediatedImmunity',s("Any","process","involved","with","the","carrying","out","of","an","immune","response","by","a","B","cell",",","through",",","for","instance",",","the","production","of","antibodies","or","cytokines",",","or","antigen","presentation","to","T","cells","."),3982969). assertion_content_comment('tOboGo_BCellNegativeSelection',s("Any","process","leading","to","negative","selection","in","B","cells",".","Mechanisms","of","negative","selection","include","anergy","and","deletion","."),4379423). assertion_content_comment('tOboGo_BCellPositiveSelection',s("Any","process","in","which","B","cells","are","selected","to","survive","based","on","signaling","through","the","B","cell","antigen","receptor","."),4379443). assertion_content_comment('tOboGo_BCellProliferationInvolvedInImmuneResponse',s("The","expansion","of","a","B","cell","population","by","cell","division","following","B","cell","activation","during","an","immune","response","."),4379939). assertion_content_comment('tOboGo_BCellProliferation',s("The","expansion","of","a","B","cell","population","by","cell","division",".","Follows","B","cell","activation","."),4061925). assertion_content_comment('tOboGo_BCellReceptorAccessoryMoleculeComplex',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4233391). assertion_content_comment('tOboGo_BCellReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4200211). assertion_content_comment('tOboGo_BCellReceptorComplex',s("An","immunoglobulin","complex","that","is","present","in","the","plasma","membrane","of","B","cells","and","that","in","its","canonical","form","is","composed","of","two","identical","immunoglobulin","heavy","chains","and","two","identical","immunoglobulin","light","chains","and","a","signaling","subunit",",","a","heterodimer","of","the","Ig-alpha","and","Ig-beta","proteins","."),4169626). assertion_content_comment('tOboGo_BCellReceptorEditing',s("The","process","of","replacing","receptors","on","B","cells",",","in","which","RAG","gene","expression","allows","continued","light-chain","gene","rearrangement","and","expression","of","a","new","light","change","which","combines","with","the","previous","heavy","chain","to","form","a","new","receptor","."),4379546). assertion_content_comment('tOboGo_BCellReceptorSignalingPathway',s("A","series","of","molecular","signals","initiated","by","the","cross-linking","of","an","antigen","receptor","on","a","B","cell","."),4100760). assertion_content_comment('tOboGo_BCellReceptorTransportIntoImmunologicalSynapse',s("The","directed","movement","of","a","B","cell","receptor","into","an","immunological","synapse","."),4331696). assertion_content_comment('tOboGo_BCellReceptorTransportIntoMembraneRaft',s("The","directed","movement","of","a","B","cell","receptor","into","a","membrane","raft","."),4331683). assertion_content_comment('tOboGo_BCellReceptorTransportWithinLipidBilayer',s("The","directed","movement","of","a","B","cell","receptor","within","a","lipid","bilayer","."),4331657). assertion_content_comment('tOboGo_BCellSelection',s("The","process","dependent","upon","B","cell","antigen","receptor","signaling","in","response","to","self","or","foreign","antigen","through","which","B","cells","are","selected","for","survival","."),3993113). assertion_content_comment('tOboGo_BCellToleranceInduction',s("A","process","involving","any","mechanism","for","tolerance","induction","in","B","cells","."),3993710). assertion_content_comment('tOboGo_BeakDevelopment',s("The","progression","of","the","beak","over","time","from","its","initial","formation","until","its","mature","state",".","The","avian","beak","is","an","external","anatomical","structure",",","in","the","head","region",",","that","is","adapted","for","feeding","self","and","young",",","catching","prey",",","probing",",","etc",".","It","encompasses",",","but","is","not","restricted","to",",","the","maxilla",",","mandible",",","maxillary","ramaphotheca",",","mandibular","ramaphotheca",",","nostril",",","nasal","fossa",",","nasal","bones",",","egg","tooth","and","rictus","."),4129263). assertion_content_comment('tOboGo_BeakFormation',s("The","process","that","gives","rise","to","the","beak",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","avian","beak","is","an","external","anatomical","structure",",","in","the","head","region",",","that","is","adapted","for","feeding","self","and","young",",","catching","prey",",","probing",",","etc",".","It","encompasses",",","but","is","not","restricted","to",",","the","maxilla",",","mandible",",","maxillary","ramaphotheca",",","mandibular","ramaphotheca",",","nostril",",","nasal","fossa",",","nasal","bones",",","egg","tooth","and","rictus","."),4129285). assertion_content_comment('tOboGo_BeakMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","beak","are","generated","and","organized",".","The","avian","beak","is","an","external","anatomical","structure",",","in","the","head","region",",","that","is","adapted","for","feeding","self","and","young",",","catching","prey",",","probing",",","etc",".","It","encompasses",",","but","is","not","restricted","to",",","the","maxilla",",","mandible",",","maxillary","ramaphotheca",",","mandibular","ramaphotheca",",","nostril",",","nasal","fossa",",","nasal","bones",",","egg","tooth","and","rictus","."),4129274). assertion_content_comment('tOboGo_BehavioralDefenseResponse',s("A","behavioral","response","seeking","to","protect","an","organism","from","an","a","perceived","external","threat","to","that","organism","."),4376997). assertion_content_comment('tOboGo_BehavioralDefenseResponseToInsect',s("A","behavioral","response","seeking","to","protect","an","organism","from","an","a","perceived","external","threat","from","an","insect","or","insects","to","that","organism","."),4377012). assertion_content_comment('tOboGo_BehavioralDefenseResponseToNematode',s("A","behavioral","response","seeking","to","protect","an","organism","from","an","a","perceived","external","threat","from","a","nematode","or","nematodes","to","that","organism","."),4377001). assertion_content_comment('tOboGo_BehavioralFearResponse',s("An","acute","behavioral","change","resulting","from","a","perceived","external","threat","."),4384087). assertion_content_comment('tOboGo_BehavioralInteractionBetweenOrganisms',s("Any","process","in","which","an","organism","has","a","behavioral","effect","on","another","organism","of","the","same","or","different","species","."),4014897). assertion_content_comment('tOboGo_BehavioralResponseToAceticAcidInducedPain',s("A","change","in","the","behaviour","of","an","organism","as","a","result","of","an","acetic","acid","pain","stimulus","."),4261512). assertion_content_comment('tOboGo_BehavioralResponseToChemicalPain',s("A","change","in","the","behaviour","of","an","organism","as","a","result","of","a","chemical","pain","stimulus","."),4261503). assertion_content_comment('tOboGo_BehavioralResponseToCocaine',s("A","change","in","the","behavior","of","an","organism","as","a","result","of","a","cocaine","stimulus","."),4255090). assertion_content_comment('tOboGo_BehavioralResponseToEthanol',s("A","change","in","the","behavior","of","an","organism","as","a","result","of","an","ethanol","stimulus","."),4299857). assertion_content_comment('tOboGo_BehavioralResponseToEther',s("A","change","in","the","behavior","of","an","organism","as","a","result","of","an","ether","stimulus","."),4299835). assertion_content_comment('tOboGo_BehavioralResponseToFormalinInducedPain',s("A","change","in","the","behaviour","of","an","organism","as","a","result","of","a","formalin","pain","stimulus","."),4261521). assertion_content_comment('tOboGo_BehavioralResponseToNicotine',s("A","change","in","the","behavior","of","an","organism","as","a","result","of","a","nicotine","stimulus","."),4381724). assertion_content_comment('tOboGo_BehavioralResponseToNutrient',s("A","change","in","the","behavior","of","an","organism","as","a","result","of","a","nutrient","stimulus","."),4235093). 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assertion_content_comment('tOboGo_Behavior',s("The","specific","actions","or","reactions","of","an","organism","in","response","to","external","or","internal","stimuli",".","Patterned","activity","of","a","whole","organism","in","a","manner","dependent","upon","some","combination","of","that","organism","'","s","internal","state","and","external","conditions","."),3990991). assertion_content_comment('tOboGo_Benomyl_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","H","+","(","out",")","+","benomyl","(","in",")","=","H","+","(","in",")","+","benomyl","(","out",")"),4296545). assertion_content_comment('tOboGo_BenomylTransporterActivity',s("Enables","the","directed","movement","of","benomyl","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Benomyl",",","methyl","1-","(","butylcarbamoyl",")","-2-benzimidazolecarbamate",",","is","a","systemic","agricultural","fungicide","used","for","control","of","certain","fungal","diseases","of","stone","fruit","."),4295277). assertion_content_comment('tOboGo_BenomylTransport',s("The","directed","movement","of","benomyl","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Benomyl",",","methyl","1-","(","butylcarbamoyl",")","-2-benzimidazolecarbamate",",","is","a","systemic","agricultural","fungicide","used","for","control","of","certain","fungal","diseases","of","stone","fruit","."),4295069). assertion_content_comment('tOboGo_BentDNABinding',s("Interacting","selectively","and","non-covalently","with","DNA","in","a","bent","conformation","."),4193540). assertion_content_comment('tOboGo_BenzaldehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","benzaldehyde","+","NAD","(","P",")","+","+","H2O","=","benzoate","+","NAD","(","P",")","H","+","H","+"),4237121). assertion_content_comment('tOboGo_BenzaldehydeDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","benzaldehyde","+","NAD","+","+","H2O","=","benzoate","+","NADH","+","H","+"),4277571). assertion_content_comment('tOboGo_BenzaldehydeDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","benzaldehyde","+","NADP","+","+","H2O","=","benzoate","+","NADPH","+","H","+"),4277550). assertion_content_comment('tOboGo_BenzeneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","benzene",",","C6H6",",","a","volatile",",","very","inflammable","liquid",",","contained","in","the","naphtha","produced","by","the","destructive","distillation","of","coal",",","from","which","it","is","separated","by","fractional","distillation","."),4272367). assertion_content_comment('tOboGo_BenzenesulfonateDioxygenaseActivity',s("Catalysis","of","the","reaction",":","toluene-4-sulfonate","+","NADH","+","O2","+","H","+","=","NAD","+","+","HSO3","(","-",")","+","4-methylcatechol","."),4276991). assertion_content_comment('tOboGo_BenzoateAminoAcidSynthetaseActivity',s("Catalysis","of","the","reaction",":","benzoate","+","ATP","+","amino","acid","=","benzoyl","amino","acid","conjugate","+","AMP","+","diphosphate","."),4191258). assertion_content_comment('tOboGo_BenzoateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","benzoate",",","the","anion","of","benzoic","acid","(","benzenecarboxylic","acid",")",",","a","fungistatic","compound","widely","used","as","a","food","preservative",";","it","is","conjugated","to","glycine","in","the","liver","and","excreted","as","hippuric","acid","."),4325193). assertion_content_comment('tOboGo_BenzoateCatabolicProcessViaCoALigation',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","benzoate",",","by","its","ligation","to","Coenzyme","A","to","form","benzoyl-CoA",",","which","is","then","broken","by","an","aerobic","or","anaerobic","pathway","."),4334416). 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assertion_content_comment('tOboGo_BenzoateTransport',s("The","directed","movement","of","benzoate",",","the","anion","of","benzoic","acid","(","benzenecarboxylic","acid",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4315891). assertion_content_comment('tOboGo_BenzodiazepineReceptorActivity',s("Combining","with","benzodiazepines",",","a","class","of","drugs","with","hypnotic",",","anxiolytic",",","anticonvulsive",",","amnestic","and","myorelaxant","properties",",","to","initiate","a","change","in","cell","activity","."),4254768). assertion_content_comment('tOboGo_BenzodiazepineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","peripheral","benzodiazepine","receptor","(","PBR",")"),4247029). assertion_content_comment('tOboGo_BenzoicAcidGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","benzoic","acid","+","UDP-glucose","=","benzoic","acid","glucose","ester","+","UDP","."),4191668). assertion_content_comment('tOboGo_BenzoinAldolaseActivity',s("Catalysis","of","the","reaction",":","benzoin","=","2","benzaldehyde","."),4371786). assertion_content_comment('tOboGo_BenzonitrileMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","benzonitrile",".","Benzonitrile","is","used","as","a","solvent","and","chemical","intermediate","in","the","pharmaceutical",",","dyestuffs","and","rubber","industries",".","It","is","highly","toxic","and","harmful","in","contact","with","skin","."),4273124). assertion_content_comment('tOboGo_BenzophenoneSynthaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxybenzoyl-CoA","+","3","malonyl-CoA","=","3","CO2","+","2",",","3","'",",","4",",","6-tetrahydroxybenzophenone","+","4","coenzyme","A","."),4366260). assertion_content_comment('tOboGo_BenzothiazoleMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","benzothiazole","+","1/2","O2","=","2-hydroxybenzothiazole","."),4350829). assertion_content_comment('tOboGo_BenzoylformateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","benzoylformate","=","benzaldehyde","+","CO2","."),4277033). assertion_content_comment('tOboGo_BenzylIsoquinolineAlkaloidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","benzyl","isoquinoline","alkaloids",",","compounds","with","bicyclic","N-containing","aromatic","rings","."),4260809). assertion_content_comment('tOboGo_BenzylIsoquinolineAlkaloidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","benzyl","isoquinoline","alkaloids",",","compounds","with","bicyclic","N-containing","aromatic","rings","."),4260806). assertion_content_comment('tOboGo_BenzylsuccinateSynthaseActivity',s("Catalysis","of","the","reaction",":","fumarate","+","toluene","=","2-benzylsuccinate","."),4274044). assertion_content_comment('tOboGo_BerbamunineSynthaseActivity',s("Catalysis","of","the","reaction",":","O2","+","NADPH","+","H","+","+","R-N-methylcoclaurine","+","S-N-methylcoclaurine","=","2","H2O","+","NADP","+","+","berbamunine","."),4364882). assertion_content_comment('tOboGo_BerberineReductaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-canadine","+","2","NADP","(","+",")","=","berberine","+","H","(","+",")","+","2","NADPH","."),4277981). assertion_content_comment('tOboGo_BergmannGlialCellDifferentiation',s("The","process","in","which","neuroepithelial","cells","of","the","neural","tube","give","rise","to","Brgmann","glial","cells",",","specialized","bipotential","progenitors","cells","of","the","cerebellum",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","."),4159248). assertion_content_comment('tOboGo_Beta2IntegrinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta","2","integrins",",","a","subfamily","of","integrins","which","contain","the","beta","2","subunit","."),4086514). assertion_content_comment('tOboGo_BetaineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","betaine",",","the","N-trimethyl","derivative","of","an","amino","acid","."),4232189). assertion_content_comment('tOboGo_BetaineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","betaine",",","the","N-trimethyl","derivative","of","an","amino","acid","."),4232204). assertion_content_comment('tOboGo_BetaineGABA_SodiumSymporterActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","(","betaine","or","gamma-aminobutyric","acid",")","(","out",")","+","Na","+","(","out",")","=","(","betaine","or","gamma-aminobutyric","acid",")","(","in",")","+","Na","+","(","in",")"),4295849). assertion_content_comment('tOboGo_BetaineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","betaine",",","the","N-trimethyl","derivative","of","an","amino","acid","."),4232177). assertion_content_comment('tOboGo_BetaineReductaseActivity',s("Catalysis","of","the","reaction",":","acetyl","phosphate","+","trimethylamine","+","thioredoxin","disulfide","=","N",",","N",",","N-trimethylglycine","+","phosphate","+","thioredoxin","."),4342375). assertion_content_comment('tOboGo_BetaineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","betaine",",","the","N-trimethyl","derivative","of","an","amino","acid",",","from","one","side","of","the","membrane","to","the","other","."),4290174). assertion_content_comment('tOboGo_BetaineTransport',s("The","directed","movement","of","betaine",",","the","N-trimethyl","derivative","of","an","amino","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4228706). assertion_content_comment('tOboGo_BetaSelection',s("The","process","in","which","successful","recombination","of","a","T","cell","receptor","beta","chain","into","a","translatable","protein","coding","sequence","leads","to","rescue","from","apoptosis","and","subsequent","proliferation","of","an","immature","T","cell","."),4095485). assertion_content_comment('tOboGo_BH1DomainBinding',s("Interacting","selectively","and","non-covalently","with","the","BH1","domain","of","a","protein","of","the","Bcl-2","family",".","Proteins","that","act","as","inhibitors","of","apoptosis","harbour","at","least","three","BH","domains",":","BH1",",","BH2","and","BH3",";","the","BH1","and","BH2","domains","are","found","in","all","death","antagonists","of","the","Bcl-2","family","but","only","in","one","class","of","death","agonists","."),4286634). assertion_content_comment('tOboGo_BH2DomainBinding',s("Interacting","selectively","and","non-covalently","with","the","BH2","domain","of","a","protein","of","the","Bcl-2","family",".","Proteins","that","act","as","inhibitors","of","apoptosis","harbour","at","least","three","BH","domains",":","BH1",",","BH2","and","BH3",";","the","BH1","and","BH2","domains","are","found","in","all","death","antagonists","of","the","Bcl-2","family","but","only","in","one","class","of","death","agonists","."),4286643). assertion_content_comment('tOboGo_BH3DomainBinding',s("Interacting","selectively","and","non-covalently","with","the","BH3","domain","of","a","protein","of","the","Bcl-2","family",".","The","BH3","domain","is","a","potent","death","domain","and","has","an","important","role","in","protein-protein","interactions","and","in","cell","death","."),4286616). assertion_content_comment('tOboGo_BH4DomainBinding',s("Interacting","selectively","and","non-covalently","with","the","BH4","domain","of","a","protein","of","the","Bcl-2","family",".","All","anti-apoptotic","proteins","contain","BH1","and","BH2","domains",";","some","also","contain","an","additional","N-terminal","BH4","domain",",","which","is","almost","never","seen","in","pro-apoptotic","proteins",".","Loss","of","the","BH4","domain","can","diminish","or","abrogate","anti-apoptotic","function","or","even","impart","outright","death-promoting","properties","to","the","protein","."),4286625). assertion_content_comment('tOboGo_BHDomainBinding',s("Interacting","selectively","and","non-covalently","with","the","Bcl-2","homology","(","BH",")","domain","of","a","protein",".","Bcl-2-related","proteins","share","homology","in","one","to","four","conserved","regions","designated","the","Bcl-2","homology","(","BH",")","domains","BH1",",","BH2",",","BH3","and","BH4",".","These","domains","contribute","at","multiple","levels","to","the","function","of","these","proteins","in","cell","death","and","survival",".","Anti-apoptotic","members","of","the","Bcl-2","family","have","four","BH","domains","(","BH1-BH4",")","Pro-apoptotic","members","have","fewer","BH","domains","."),4286612). assertion_content_comment('tOboGo_BHLHTranscriptionFactorBinding',s("Interacting","selectively","and","non-covalently","with","any","of","the","basic","Helix-Loop-Helix","(","bHLH",")","superfamily","of","transcription","factors",",","important","regulatory","components","in","transcriptional","networks","of","many","developmental","pathways","."),4284063). assertion_content_comment('tOboGo_BicarbonateBinding',s("Interacting","selectively","and","non-covalently","with","bicarbonate","(","CHO3-",")","ions","."),4170698). assertion_content_comment('tOboGo_BicarbonateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","bicarbonate","from","one","side","of","a","membrane","to","the","other",".","Bicarbonate","is","the","hydrogencarbonate","ion",",","HCO3-","."),4254651). assertion_content_comment('tOboGo_BicarbonateTransport',s("The","directed","movement","of","bicarbonate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290918). assertion_content_comment('tOboGo_BicoidMRNALocalization',s("Any","process","in","which","bicoid","mRNA","is","transported","to","and","maintained","within","the","oocyte","as","part","of","the","specification","of","the","anterior/posterior","axis","."),4020670). assertion_content_comment('tOboGo_BicyclomycinSulfathiazole_HydrogenAntiporterActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","(","bicyclomycin","or","sulfathiazole",")","(","in",")","+","H","+","(","out",")","=","(","bicyclomycin","or","sulfathiazole",")","(","out",")","+","H","+","(","in",")"),4292948). assertion_content_comment('tOboGo_BicyclomycinTransporterActivity',s("Enables","the","directed","movement","of","bicyclomycin","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Bicyclomycin","(","or","bicozamycin",")","is","an","antibacterial","drug","often","used","as","a","livestock","feed","additive","."),4292910). assertion_content_comment('tOboGo_BicyclomycinTransport',s("The","directed","movement","of","bicyclomycin","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Bicyclomycin","(","or","bicozamycin",")","is","an","antibacterial","drug","often","used","as","a","livestock","feed","additive","."),4294406). assertion_content_comment('tOboGo_BidentateRibonucleaseIIIActivity',s("Catalysis","of","the","digestion","of","double-stranded","RNAs","into","20","to","30-nucleotide","products",".","These","products","typically","associate","to","the","RNA-induced","silencing","complex","and","serve","as","guide","RNAs","for","posttranslational","RNA","interference","."),4304950). assertion_content_comment('tOboGo_BilateralProcess',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4234615). assertion_content_comment('tOboGo_BileAcidAndBileSaltTransport',s("The","directed","movement","of","bile","acid","and","bile","salts","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290618). assertion_content_comment('tOboGo_BileAcidBinding',s("Interacting","selectively","and","non-covalently","with","bile","acids",",","any","of","a","group","of","steroid","carboxylic","acids","occurring","in","bile","."),4330306). assertion_content_comment('tOboGo_BileAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","bile","acids",",","any","of","a","group","of","steroid","carboxylic","acids","occurring","in","bile","."),4132156). assertion_content_comment('tOboGo_BileAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","bile","acids",",","any","of","a","group","of","steroid","carboxylic","acids","occurring","in","bile","."),4310661). assertion_content_comment('tOboGo_BileAcidConjugation',s("The","process","in","which","bile","acids","are","covalently","linked","to","taurine","or","glycine","."),4375337). assertion_content_comment('tOboGo_BileAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","bile","acids",",","any","of","a","group","of","steroid","carboxylic","acids","occurring","in","bile",",","where","they","are","present","as","the","sodium","salts","of","their","amides","with","glycine","or","taurine","."),4132152). assertion_content_comment('tOboGo_BileAcidSecretion',s("The","regulated","release","of","bile","acid",",","composed","of","any","of","a","group","of","steroid","carboxylic","acids","occurring","in","bile",",","by","a","cell","or","group","of","cells","."),4337614). assertion_content_comment('tOboGo_BileAcid_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","bile","acid","(","out",")","+","Na","+","(","out",")","=","bile","acid","(","in",")","+","Na","+","(","in",")"),4254725). assertion_content_comment('tOboGo_BileAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","bile","acid","from","one","side","of","the","membrane","to","the","other",".","Bile","acids","are","any","of","a","group","of","steroid","carboxylic","acids","occurring","in","bile",",","where","they","are","present","as","the","sodium","salts","of","their","amides","with","glycine","or","taurine","."),4254723). assertion_content_comment('tOboGo_BilirubinConjugation',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","bilirubin","monoglucuronide","or","bilirubin","diglucuronide",",","water-soluble","derivatives","of","bilirubin","."),4229797). assertion_content_comment('tOboGo_BilirubinOxidaseActivity',s("Catalysis","of","the","reaction",":","2","bilirubin","+","O","(","2",")","=","2","biliverdin","+","2","H","(","2",")","O","."),4374378). assertion_content_comment('tOboGo_BilirubinSecondaryActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","bilirubin","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4296052). assertion_content_comment('tOboGo_BilirubinTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","bilirubin","from","one","side","of","the","membrane","to","the","other",".","Bilirubin","is","a","linear","tetrapyrrole","produced","in","the","reticuloendothelial","system","from","biliverdin","and","transported","to","the","liver","as","a","complex","with","serum","albumin",".","In","the","liver",",","bilirubin","is","converted","to","bilirubin","bisglucuronide",",","which","is","excreted","in","the","bile","."),4296049). assertion_content_comment('tOboGo_BilirubinTransport',s("The","directed","movement","of","bilirubin","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290602). assertion_content_comment('tOboGo_BiliverdinReductaseActivity',s("Catalysis","of","the","reaction",":","bilirubin","+","NAD","(","P",")","+","=","biliverdin","+","NAD","(","P",")","H","+","H","+"),4212597). assertion_content_comment('tOboGo_BindingBridging',s("The","binding","activity","of","a","molecule","that","brings","together","two","or","more","molecules",",","permitting","those","molecules","to","function","in","a","coordinated","way","."),4074012). assertion_content_comment('tOboGo_BindingOfSpermToZonaPellucida',s("The","process","in","which","the","sperm","binds","to","the","zona","pellucida","glycoprotein","layer","of","the","egg",".","The","process","begins","with","the","attachment","of","the","sperm","plasma","membrane","to","the","zona","pellucida","and","includes","attachment","of","the","acrosome","inner","membrane","to","the","zona","pellucida","after","the","acrosomal","reaction","takes","place","."),4142868). assertion_content_comment('tOboGo_Binding',s("The","selective",",","non-covalent",",","often","stoichiometric",",","interaction","of","a","molecule","with","one","or","more","specific","sites","on","another","molecule","."),3975003). assertion_content_comment('tOboGo_BindingToMRNACap',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4224056). assertion_content_comment('tOboGo_BindingUnfoldedERProteins',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4224034). assertion_content_comment('tOboGo_BioactiveLipidReceptorActivity',s("Combining","with","a","bioactive","lipid","to","initiate","a","change","in","cell","activity",".","A","bioactive","lipid","is","a","lipid","for","which","changes","in","lipid","levels","result","in","functional","consequences","in","a","variety","of","cellular","processes","."),4178255). assertion_content_comment('tOboGo_BiofilmFormation',s("A","process","in","which","microorganisms","irreversibly","attach","to","and","grow","on","a","surface","and","produce","extracellular","polymers","that","facilitate","attachment","and","matrix","formation",",","resulting","in","an","alteration","in","the","phenotype","of","the","organisms","with","respect","to","growth","rate","and","gene","transcription","."),4095232). assertion_content_comment('tOboGo_BiologicalAdhesion',s("The","attachment","of","a","cell","or","organism","to","a","substrate","or","other","organism","."),3977544). assertion_content_comment('tOboGo_Bioluminescence',s("The","production","of","light","by","certain","enzyme-catalyzed","reactions","in","cells","."),4256106). assertion_content_comment('tOboGo_BiomineralTissueDevelopment',s("Formation","of","hard","tissues","that","consist","mainly","of","inorganic","compounds",",","and","also","contain","a","small","amounts","of","organic","matrices","that","are","believed","to","play","important","roles","in","their","formation","."),4046703). assertion_content_comment('tOboGo_BiopterinTransporterActivity',s("Enables","the","directed","movement","of","biopterin","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Biopterin","is","a","growth","factor","for","certain","protozoans","and","some","insects",";","it","is","widely","distributed","in","tissues","and","functions","in","a","reduced","form",",","tetrahydrobiopterin",",","as","a","hydroxylation","coenzyme","."),4295560). assertion_content_comment('tOboGo_BiopterinTransport',s("The","directed","movement","of","biopterin","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Biopterin","is","a","growth","factor","for","certain","protozoans","and","some","insects",";","it","is","widely","distributed","in","tissues","and","functions","in","a","reduced","form",",","tetrahydrobiopterin",",","as","a","hydroxylation","coenzyme","."),4294320). assertion_content_comment('tOboGo_BiosynthesisByHostOfSubstanceInSymbiont',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","its","symbiont","resulting","in","the","formation","of","substances",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197109). assertion_content_comment('tOboGo_BiosynthesisBySymbiontOfSubstanceInHost',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","its","host","resulting","in","the","formation","of","substances",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194811). assertion_content_comment('tOboGo_BiosynthesisOfLactosylceramidePrecursorToGanglioside',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lactosylceramides",",","Gal","beta","(","1",",","4",")","Glc","beta","(","1",",","1","'",")","ceramides",",","any","compound","formed","by","the","replacement","of","the","glycosidic","C1","hydroxyl","group","of","lactose","by","a","ceramide","group","as","a","precursor","of","gangliosides","."),4336686). assertion_content_comment('tOboGo_BiosynthesisOfLactosylceramidePrecursorToGloboside',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lactosylceramides",",","Gal","beta","(","1",",","4",")","Glc","beta","(","1",",","1","'",")","ceramides",",","any","compound","formed","by","the","replacement","of","the","glycosidic","C1","hydroxyl","group","of","lactose","by","a","ceramide","group","as","a","precursor","of","globosides","."),4336659). assertion_content_comment('tOboGo_BiosynthesisOfSubstanceInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","a","second","organism","resulting","in","the","formation","of","substances",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4194808). assertion_content_comment('tOboGo_BiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","substances",";","typically","the","energy-requiring","part","of","metabolism","in","which","simpler","substances","are","transformed","into","more","complex","ones","."),3970920). assertion_content_comment('tOboGo_BiotinBinding',s("Interacting","selectively","and","non-covalently","with","biotin","(","cis-tetrahydro-2-oxothieno","(","3",",","4-d",")","imidazoline-4-valeric","acid",")",",","the","(","+",")","enantiomer","of","which","is","very","widely","distributed","in","cells","and","serves","as","a","carrier","in","a","number","of","enzymatic","beta-carboxylation","reactions","."),4260056). assertion_content_comment('tOboGo_BiotinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","biotin",",","cis-tetrahydro-2-oxothieno","(","3",",","4-d",")","imidazoline-4-valeric","acid","."),4046121). assertion_content_comment('tOboGo_BiotinCarboxylaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","biotin-carboxyl-carrier","protein","+","CO2","=","ADP","+","phosphate","+","carboxybiotin-carboxyl-carrier","protein","."),4212608). assertion_content_comment('tOboGo_BiotinCarboxylaseComplex',s("An","enzyme","complex","that","catalyzes","the","formation","of","carboxybiotin-carboxyl-carrier","protein","from","biotin-carboxyl-carrier","protein","and","carbon","dioxide","(","CO2",")"),4023752). 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assertion_content_comment('tOboGo_BiotinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","biotin",",","cis-tetrahydro-2-oxothieno","(","3",",","4-d",")","imidazoline-4-valeric","acid",";","the","(","+",")","enantiomer","is","very","widely","distributed","in","cells","and","serves","as","a","carrier","in","a","number","of","enzymatic","beta-carboxylation","reactions","."),4046084). assertion_content_comment('tOboGo_BiotinSynthaseActivity',s("Catalysis","of","the","reaction",":","2","S-adenosyl-L-methionine","+","dethiobiotin","+","S","(","2-",")","=","2","5","'","-deoxyadenosine","+","2","L-methionine","+","biotin","+","H","(","+",")"),4212564). assertion_content_comment('tOboGo_BiotinTransporterActivity',s("Enables","the","directed","movement","of","biotin","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Biotin","is","cis-tetrahydro-2-oxothieno","(","3",",","4-d",")","imidazoline-4-valeric","acid",";","the","(","+",")","enantiomer","is","very","widely","distributed","in","cells","and","serves","as","a","carrier","in","a","number","of","enzymatic","beta-carboxylation","reactions","."),4295570). assertion_content_comment('tOboGo_BiotinTransport',s("The","directed","movement","of","biotin","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Biotin","is","cis-tetrahydro-2-oxothieno","(","3",",","4-d",")","imidazoline-4-valeric","acid",";","the","(","+",")","enantiomer","is","very","widely","distributed","in","cells","and","serves","as","a","carrier","in","a","number","of","enzymatic","beta-carboxylation","reactions","."),4294342). assertion_content_comment('tOboGo_BipartiteViralGenome',s("A","segmented","viral","genome","consisting","of","two","sub-genomic","nucleic","acids","but","each","nucleic","acid","is","packaged","into","a","different","virion","."),4236344). assertion_content_comment('tOboGo_BiphenylCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","biphenyl",",","a","toxic","aromatic","hydrocarbon","used","as","a","heat","transfer","agent",",","as","a","fungistat","in","packaging","citrus","fruits","and","in","plant","disease","control",".","Biphenyl","can","be","chlorinated","with","1-10","chlorine","molecules","to","form","polychlorinated","biphenyls","(","PCBs",")"),4177618). assertion_content_comment('tOboGo_BiphenylMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","biphenyl",",","a","toxic","aromatic","hydrocarbon","used","as","a","heat","transfer","agent",",","as","a","fungistat","in","packaging","citrus","fruits","and","in","plant","disease","control",".","Biphenyl","can","be","chlorinated","with","1-10","chlorine","molecules","to","form","polychlorinated","biphenyls","(","PCBs",")"),4177598). assertion_content_comment('tOboGo_BiphenylSynthaseActivity',s("Catalysis","of","the","reaction",":","3","malonyl-CoA","+","benzoyl-CoA","=","4","CoA","+","3",",","5-dihydroxybiphenyl","+","4","CO2","."),4343098). assertion_content_comment('tOboGo_BipolarCellGrowth',s("The","process","in","which","a","cell","irreversibly","increases","in","size","along","one","axis","through","simultaneous","polarized","growth","from","opposite","ends","of","a","cell",",","resulting","in","morphogenesis","of","the","cell","."),4118749). assertion_content_comment('tOboGo_BipolarCellularBudSiteSelection',s("The","process","of","defining","subsequent","sites","of","bud","emergence","such","that","budding","takes","place","at","alternating","poles","of","a","budding","cell","."),4236123). assertion_content_comment('tOboGo_BisphenolACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","bisphenol","A",",","4",",","4","'","-","(","propane-2",",","2-diyl",")","diphenol",",","a","synthetic",",","aromatic","organic","compound","used","as","a","monomer","in","the","manufacture","of","polycarbonate","plastic","and","in","the","manufacture","of","epoxy","resins","."),4325139). assertion_content_comment('tOboGo_BisphenolAHydroxylaseAActivity',s("Catalysis","of","the","reaction",":","bisphenol","A","+","NADH","+","H","+","+","O2","=","2",",","2-bis","(","4-hydroxyphenyl",")","-1-propanol","+","NAD","+","+","H2O","."),4352534). assertion_content_comment('tOboGo_BisphenolAHydroxylaseBActivity',s("Catalysis","of","the","reaction",":","bisphenol","A","+","NADH","+","H","+","+","O2","=","1",",","2-bis","(","4-hydroxyphenyl",")","-2-propanol","+","NAD","+","+","H2O","."),4352525). assertion_content_comment('tOboGo_BisphosphoglycerateMutaseActivity',s("Catalysis","of","the","reaction",":","3-phospho-D-glyceroyl","phosphate","=","2",",","3-bisphospho-D-glycerate","."),4212464). assertion_content_comment('tOboGo_BisphosphoglyceratePhosphataseActivity',s("Catalysis","of","the","reaction",":","2",",","3-diphosphoglycerate","+","H2O","=","phosphoglycerate","+","phosphate","."),4212332). assertion_content_comment('tOboGo_BisulfiteReduction',s("The","chemical","reactions","and","pathways","resulting","in","the","reduction","of","sulfate","to","thiosulfate","via","bisulfite","."),4240854). assertion_content_comment('tOboGo_BitterTasteReceptorActivity',s("Combining","with","soluble","bitter","compounds","to","initiate","a","change","in","cell","activity",".","These","receptors","are","responsible","for","the","sense","of","bitter","taste","."),4347608). assertion_content_comment('tOboGo_BiuretAmidohydrolaseActivity',s("Catalysis","of","the","reaction",":","biuret","+","H2O","=","urea","+","CO2","+","NH3","."),4274732). assertion_content_comment('tOboGo_BlastocystDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","blastocyst","over","time",",","from","its","formation","to","the","mature","structure",".","The","mammalian","blastocyst","is","a","hollow","ball","of","cells","containing","two","cell","types",",","the","inner","cell","mass","and","the","trophectoderm","."),3986930). assertion_content_comment('tOboGo_BlastocystFormation',s("The","initial","formation","of","a","blastocyst","from","a","solid","ball","of","cells","known","as","a","morula","."),3986932). assertion_content_comment('tOboGo_BlastocystGrowth',s("An","increase","in","size","of","a","blastocyst","due","to","expansion","of","the","blastocoelic","cavity","cell","shape","changes","and","cell","proliferation","."),3986979). assertion_content_comment('tOboGo_BlastocystHatching',s("The","hatching","of","the","cellular","blastocyst","from","the","zona","pellucida","."),3987117). assertion_content_comment('tOboGo_BlastodermSegmentation',s("The","hierarchical","steps","resulting","in","the","progressive","subdivision","of","the","anterior/posterior","axis","of","the","embryo","."),4018945). assertion_content_comment('tOboGo_BlebAssembly',s("The","assembly","of","a","bleb",",","a","cell","extension","characterized","by","rapid","formation",",","rounded","shape",",","and","scarcity","of","organelles","within","the","protrusions","."),4330376). assertion_content_comment('tOboGo_Bleb',s("A","cell","extension","characterized","by","rapid","formation",",","rounded","shape",",","and","scarcity","of","organelles","within","the","protrusions","."),4330334). assertion_content_comment('tOboGo_BleomycinHydrolaseActivity',s("OBSOLETE",".","Catalysis","of","the","inactivation","of","bleomycin","B2","(","a","cytotoxic","glycometallopeptide",")","by","hydrolysis","of","a","peptide","bond","of","beta-aminoalanine",",","but","also","shows","general","aminopeptidase","activity",".","The","specificity","varies","somewhat","with","source",",","but","amino","acid","arylamides","of","Met",",","Leu","and","Ala","are","preferred","."),4253476). assertion_content_comment('tOboGo_BLOCComplex',s("Any","of","several","protein","complexes","required","for","the","biogenesis","of","specialized","organelles","of","the","endosomal-lysosomal","system",",","such","as","melanosomes",",","platelet","dense","granules",",","and","other","related","organelles",";","acronym","for","biogenesis","of","lysosomal-related","organelles","complex","."),4319292). assertion_content_comment('tOboGo_BloodCirculation',s("The","flow","of","blood","through","the","body","of","an","animal",",","enabling","the","transport","of","nutrients","to","the","tissues","and","the","removal","of","waste","products","."),3987259). assertion_content_comment('tOboGo_BloodCoagulationCommonPathway',s("A","protein","activation","cascade","that","contributes","to","blood","coagulation","and","consists","of","events","leading","from","the","formation","of","activated","factor","X","to","the","formation","of","active","thrombin",",","the","cleavage","of","fibrinogen","by","thrombin",",","and","the","formation","of","cleaved","fibrin","into","a","stable","multimeric",",","cross-linked","complex","."),4127036). assertion_content_comment('tOboGo_BloodCoagulationExtrinsicPathway',s("A","protein","activation","cascade","that","contributes","to","blood","coagulation","and","consists","of","the","self-limited","process","linking","exposure","and","activation","of","tissue","factor","to","the","activation","of","clotting","factor","X","."),4016023). assertion_content_comment('tOboGo_BloodCoagulationFactorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4187699). assertion_content_comment('tOboGo_BloodCoagulationFibrinClotFormation',s("A","protein","activation","cascade","that","contributes","to","blood","coagulation","and","consists","of","the","cascade","of","enzymatic","reactions","initiated","by","physical","damage","to","the","wall","of","a","blood","vessel",",","leading","to","the","formation","of","a","formation","of","a","fibrin","clot","at","the","site","of","the","injury",".","The","process","also","includes","numerous","positive","and","negative","regulatory","events","."),4016001). assertion_content_comment('tOboGo_BloodCoagulationIntrinsicPathway',s("A","protein","activation","cascade","that","contributes","to","blood","coagulation","and","consists","of","the","interactions","among","high","molecular","weight","kininogen",",","prekallikrein",",","and","factor","XII","that","lead","to","the","activation","of","clotting","factor","X","."),4016012). assertion_content_comment('tOboGo_BloodCoagulation',s("The","sequential","process","in","which","the","multiple","coagulation","factors","of","the","blood","interact",",","ultimately","resulting","in","the","formation","of","an","insoluble","fibrin","clot",";","it","may","be","divided","into","three","stages",":","stage","1",",","the","formation","of","intrinsic","and","extrinsic","prothrombin","converting","principle",";","stage","2",",","the","formation","of","thrombin",";","stage","3",",","the","formation","of","stable","fibrin","polymers","."),3996560). assertion_content_comment('tOboGo_BloodGroupAntigen',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218254). assertion_content_comment('tOboGo_BloodMicroparticleFormation',s("The","cellular","component","organization","process","in","which","microparticles","bud","off","from","a","parent","cell",".","A","microparticle","is","a","phospholipid","microvesicle","that","is","derived","from","any","of","several","cell","types",",","such","as","platelets",",","blood","cells",",","endothelial","cells",",","or","others",",","and","contains","membrane","receptors","as","well","as","other","proteins","characteristic","of","the","parental","cell","."),4143131). assertion_content_comment('tOboGo_BloodMicroparticle',s("A","phospholipid","microvesicle","that","is","derived","from","any","of","several","cell","types",",","such","as","platelets",",","blood","cells",",","endothelial","cells",",","or","others",",","and","contains","membrane","receptors","as","well","as","other","proteins","characteristic","of","the","parental","cell",".","Microparticles","are","heterogeneous","in","size",",","and","are","characterized","as","microvesicles","free","of","nucleic","acids","."),4126025). assertion_content_comment('tOboGo_BloodVesselDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","blood","vessel","over","time",",","from","its","formation","to","the","mature","structure",".","The","blood","vessel","is","the","vasculature","carrying","blood","."),3980673). assertion_content_comment('tOboGo_BloodVesselEndothelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","blood","vessel","endothelial","cell",",","a","thin","flattened","cell","that","lines","the","inside","surfaces","of","blood","vessels","."),4113754). assertion_content_comment('tOboGo_BloodVesselEndothelialCellFateCommitment',s("The","commitment","of","a","cell","to","a","blood","vessel","endothelial","cell","fate","and","its","capacity","to","differentiate","into","a","blood","vessel","endothelial","cell","."),4113810). assertion_content_comment('tOboGo_BloodVesselEndothelialCellMigrationInvolvedInIntussusceptiveAngiogenesis',s("The","orderly","movement","of","endothelial","cells","into","the","extracellular","matrix","in","order","to","form","new","blood","vessels","during","intussusceptive","angiogenesis","."),3990890). assertion_content_comment('tOboGo_BloodVesselEndothelialCellMigration',s("The","orderly","movement","of","an","endothelial","cell","into","the","extracellular","matrix","in","order","to","form","new","blood","vessels","during","angiogenesis","."),3990785). assertion_content_comment('tOboGo_BloodVesselEndothelialCellProliferationInvolvedInSproutingAngiogenesis',s("The","multiplication","or","reproduction","of","blood","vessel","endothelial","cells",",","resulting","in","the","expansion","of","a","cell","population","contributing","to","sprouting","angiogenesis","."),3990910). assertion_content_comment('tOboGo_BloodVesselLumenization',s("The","process","in","which","a","developing","blood","vessel","forms","an","endothelial","lumen","through","which","blood","will","flow","."),4126014). assertion_content_comment('tOboGo_BloodVesselMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","blood","vessel","to","attain","its","fully","functional","state","."),3988261). assertion_content_comment('tOboGo_BloodVesselMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","blood","vessels","are","generated","and","organized",".","The","blood","vessel","is","the","vasculature","carrying","blood","."),3980675). assertion_content_comment('tOboGo_BloodVesselRemodeling',s("The","reorganization","or","renovation","of","existing","blood","vessels","."),4114792). assertion_content_comment('tOboGo_BlueLightPhotoreceptorActivity',s("The","function","of","absorbing","and","responding","to","electromagnetic","radiation","with","a","wavelength","of","approximately","400-470nm",".","The","response","may","involve","a","change","in","conformation","."),4262248). assertion_content_comment('tOboGo_BlueLightSignalingPathway',s("The","series","of","molecular","signals","initiated","upon","sensing","of","blue","light","by","photoreceptor","molecule",",","at","a","wavelength","between","400nm","and","470nm","."),4262841). assertion_content_comment('tOboGo_BMKCascade',s("A","cascade","of","protein","kinase","activities",",","culminating","in","the","phosphorylation","and","activation","of","big","MAP","kinase","(","BMK1/ERK5",")",",","which","is","a","type","of","mitogen-activated","protein","(","MAP",")","kinase","."),4136251). assertion_content_comment('tOboGo_BMPReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","BMP","receptor","."),4176508). assertion_content_comment('tOboGo_BMPReceptorComplex',s("A","protein","complex","that","acts","as","a","receptor","for","bone","morphogenetic","proteins","(","BMPs",")",";","a","homo-","or","heterodimer","of","type","I","and/or","type","II","BMP","receptor","subunits","."),4130277). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInDeterminationOfLateralMesodermLeftRightAsymmetry',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","contributes","to","the","determination","of","lateral","mesoderm","left/right","asymmetry","."),4003617). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInDeterminationOfLeftRightSymmetry',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","contributes","to","the","determination","of","left/right","symmetry","."),4001899). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInForebrainNeuronFateCommitment',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","bone","morphogenic","protein","receptor","binding","to","one","of","its","physiological","ligands","that","contributes","to","the","commitment","of","a","neuroblast","to","a","neuronal","fate",".","The","neuron","will","reside","in","the","forebrain","."),4053392). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInGrowthPlateCartilageChondrocyteDevelopment',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","contributes","to","the","progression","of","a","growth","plate","cartilage","chondrocyte","over","time","."),4004198). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInHeartDevelopment',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","and","contributing","to","the","progression","of","the","heart","over","time","."),4001276). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInHeartInduction',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","contributes","to","heart","induction","."),4003245). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInHeartJogging',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","bone","morphogenic","protein","receptor","binding","to","one","of","its","physiological","ligands","that","contributes","to","the","process","of","heart","jogging","."),4001905). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInMalpighianTubuleCellChemotaxis',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","BMP","receptor","binding","to","one","of","its","physiological","ligands","leading","to","the","directed","movement","of","a","Malpighian","tubule","cells","toward","a","stimulus","and","contributing","to","the","shaping","of","the","tubule","."),4135104). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInMesodermalCellFateSpecification',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","and","ultimately","resulting","in","an","cell","becoming","specified","to","adopt","a","mesodermal","fate","."),4111123). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInNephricDuctFormation',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","contributes","to","nephric","duct","formation","."),4125579). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInRegulationOfSecondaryHeartFieldCardioblastProliferation',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","contributing","to","the","modulation","of","the","frequency",",","rate","or","extent","of","cardioblast","proliferation",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4001280). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInRenalSystemSegmentation',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","and","contributing","to","the","segmentation","of","the","renal","system","."),4135804). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInSpinalCordAssociationNeuronSpecification',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","contributes","to","its","commitment","to","an","association","neuron","fate","."),4049413). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInSpinalCordDorsalVentralPatterning',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","results","in","the","spatial","identity","of","regions","along","the","dorsal-ventral","axis","of","the","spinal","cord","."),4048438). assertion_content_comment('tOboGo_BMPSignalingPathwayInvolvedInUreterMorphogenesis',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","that","contributes","to","the","shaping","of","the","ureter",".","The","ureter","is","a","tube","that","extends","from","the","kidney","to","the","bladder","."),4135571). assertion_content_comment('tOboGo_BMPSignalingPathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","any","member","of","the","BMP","(","bone","morphogenetic","protein",")","family","binding","to","a","cell","surface","receptor","."),4001269). assertion_content_comment('tOboGo_BodyFluidSecretion',s("The","controlled","release","of","a","fluid","by","a","cell","or","group","of","cells","in","an","animal","."),4015266). assertion_content_comment('tOboGo_BodyMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","soma","are","generated","and","organized","."),4114731). 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assertion_content_comment('tOboGo_BolwigSOrganMorphogenesis',s("The","morphogenetic","process","in","which","the","anatomical","structures","of","the","larval","eye","in","Drosophila","are","generated","and","organized",".","The","larval","eye","in","Drosophila","is","a","relatively","simple","sensory","system","composed","of","Bolwig","'","s","organs",":","two","clusters",",","each","composed","of","12","photoreceptor","cells","from","which","axons","extend","in","a","single","fascicle","to","the","brain","."),3985182). assertion_content_comment('tOboGo_BombesinReceptorActivity',s("Combining","with","bombesin","to","initiate","a","change","in","cell","activity","."),4197740). assertion_content_comment('tOboGo_BombesinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","bombesin","receptor","."),4323019). 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assertion_content_comment('tOboGo_BoxCDSnoRNPComplex',s("A","ribonucleoprotein","complex","containing","small","nucleolar","RNA","of","the","box","C/D","type","that","can","carry","out","ribose-2","'","-O-methylation","of","target","RNAs","."),4321356). assertion_content_comment('tOboGo_BoxCDSnoRNPProtein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4219802). assertion_content_comment('tOboGo_BoxHACARNPComplex',s("A","ribonucleoprotein","complex","that","contains","an","RNA","of","the","box","H/ACA","type",",","a","subtype","of","the","small","nucleolar","RNA","(","snoRNA",")","family",".","RNA","pseudouridylation","(","isomerization","of","uridine","to","pseudouridine",")","is","the","major",",","and","most","likely","the","ancestral",",","function","of","H/ACA","RNPs",",","although","some","have","evolved","other","functions",".","Pseudouridylation","targets","include","both","large","and","small","ribosomal","RNAs","(","rRNAs",")",",","and","on","U2","small","nuclear","RNA","(","U2","snRNA",")"),4126641). assertion_content_comment('tOboGo_BoxHACAScaRNPComplex',s("A","box","H/ACA","RNP","complex","that","is","located","in","the","Cajal","body","of","the","nucleoplasm",".","In","higher","eukaryotes",",","box","H/ACA","RNP","located","in","Cajal","bodies","mediate","pseudouridylation","of","spliceosomal","snRNAs","."),4126646). assertion_content_comment('tOboGo_BoxHACASnoRNABinding',s("Interacting","selectively","and","non-covalently","with","box","H/ACA","small","nucleolar","RNA","."),4352264). assertion_content_comment('tOboGo_BoxHACASnoRNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","box","H/ACA","type","small","nucleolar","RNA","."),4344973). assertion_content_comment('tOboGo_BoxHACASnoRNAProcessing',s("Any","process","involved","in","the","conversion","of","a","primary","box","H/ACA","type","small","nucleolar","RNA","(","snoRNA",")","transcript","into","a","mature","box","H/ACA","snoRNA","."),4348638). assertion_content_comment('tOboGo_BoxHACASnoRNPAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","a","box","H/ACA","snoRNA","to","form","a","box","H/ACA","small","nucleolar","ribonucleoprotein","(","snoRNP",")","complex","."),4362402). assertion_content_comment('tOboGo_BoxHACASnoRNPComplex',s("A","box","H/ACA","RNP","complex","that","is","located","in","the","nucleolus","."),4321345). assertion_content_comment('tOboGo_BoxHACASnoRNPProtein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4219812). assertion_content_comment('tOboGo_BractDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","bract","over","time",",","from","its","formation","to","the","mature","structure",".","A","bract","is","a","leaf",",","usually","different","in","form","from","the","foliage","leaves",",","subtending","a","flower","or","inflorescence","."),4029182). assertion_content_comment('tOboGo_BractFormation',s("The","process","that","gives","rise","to","a","bract",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","A","bract","is","a","leaf",",","usually","different","in","form","from","the","foliage","leaves",",","subtending","a","flower","or","inflorescence","."),4029194). assertion_content_comment('tOboGo_BractMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","a","bract","are","generated","and","organized",".","A","bract","is","a","leaf",",","usually","different","in","form","from","the","foliage","leaves",",","subtending","a","flower","or","inflorescence","."),4029184). assertion_content_comment('tOboGo_BradykininCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","peptide","bradykinin","."),4335927). assertion_content_comment('tOboGo_BradykininReceptorActivity',s("Combining","with","bradykinin","to","initiate","a","change","in","cell","activity","."),4197749). assertion_content_comment('tOboGo_BradykininReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","bradykinin","receptor","."),4323188). assertion_content_comment('tOboGo_BrahmaComplex',s("A","SWI/SNF-type","complex","that","contains","the","ATPase","product","of","the","Drosophila","brahma","gene",",","or","an","ortholog","thereof","."),4381828). assertion_content_comment('tOboGo_BrainDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","brain","over","time",",","from","its","formation","to","the","mature","structure",".","Brain","development","begins","with","patterning","events","in","the","neural","tube","and","ends","with","the","mature","structure","that","is","the","center","of","thought","and","emotion",".","The","brain","is","responsible","for","the","coordination","and","control","of","bodily","activities","and","the","interpretation","of","information","from","the","senses","(","sight",",","hearing",",","smell",",","etc.",")"),4017358). assertion_content_comment('tOboGo_BrainMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","brain","are","generated","and","organized",".","The","brain","is","one","of","the","two","components","of","the","central","nervous","system","and","is","the","center","of","thought","and","emotion",".","It","is","responsible","for","the","coordination","and","control","of","bodily","activities","and","the","interpretation","of","information","from","the","senses","(","sight",",","hearing",",","smell",",","etc.",")"),4105592). assertion_content_comment('tOboGo_BrainSegmentation',s("Division","of","the","brain","into","a","series","of","semi-repetitive","parts","or","segments","."),4071204). assertion_content_comment('tOboGo_BrainstemDevelopment',s("The","progression","of","the","brainstem","from","its","formation","to","the","mature","structure",".","The","brainstem","is","the","part","of","the","brain","that","connects","the","brain","with","the","spinal","cord","."),4005771). assertion_content_comment('tOboGo_BrainstemPrecerebellarNeuronPrecursorMigration',s("The","early","migration","of","a","precerebellar","neuronal","precursor","in","which","a","cell","move","from","the","rhombic","lip",",","orthogonal","to","the","direction","of","radial","migration","and","ultimately","reside","in","the","brainstem","."),4047826). assertion_content_comment('tOboGo_BranchedChainFamilyAminoAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","amino","acids","containing","a","branched","carbon","skeleton",",","comprising","isoleucine",",","leucine","and","valine","."),4257093). 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assertion_content_comment('tOboGo_BranchedChainFamilyAminoAcidCatabolicProcessToAlcoholViaEhrlichPathway',s("The","chemical","reactions","and","pathways","involving","the","catabolism","of","branched","chain","amino","acids","to","produce","branched","chain","alcohols","with","one","carbon","less","than","the","starting","amino","acid",".","In","S",".","cerevisiae",",","this","is","known","to","occur","for","leucine",",","isoleucine",",","valine",",","methionine",",","phenylalanine",",","tyrosine",",","or","tryptophan",".","When","a","branched","chain","family","amino","acid",",","leucine",",","isoleucine",",","or","valine",",","is","used","as","the","substrate",",","3-methylbutanol",",","2-methylbutanol",",","or","2-methylpropanol",",","respectively",",","is","produced",".","Often","referred","to","as","the","Ehrlich","pathway",",","these","reactions","generally","occur","during","fermentation","to","produce","a","variety","of","alcohols",",","often","collectively","referred","to","as","fusel","alcohols",".","Depending","on","the","redox","state","of","the","cells",",","carboxylic","acid","derivatives","may","be","produced","instead","of","alcohols","."),4363147). 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assertion_content_comment('tOboGo_BrassinosteroidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","brassinosteroids",",","any","of","a","group","of","steroid","derivatives","that","occur","at","very","low","concentrations","in","plant","tissues","and","may","have","hormone-like","effects","."),4029254). assertion_content_comment('tOboGo_BrassinosteroidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","brassinosteroids",",","any","of","a","group","of","steroid","derivatives","that","occur","at","very","low","concentrations","in","plant","tissues","and","may","have","hormone-like","effects","."),4303030). assertion_content_comment('tOboGo_BrassinosteroidHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","brassinosteroids","within","an","organism","or","cell","."),4335387). assertion_content_comment('tOboGo_BrassinosteroidMediatedSignalingPathway',s("A","series","of","molecular","signals","mediated","by","the","detection","of","brassinosteroid","."),4260391). assertion_content_comment('tOboGo_BrassinosteroidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","brassinosteroids",",","any","of","a","group","of","steroid","derivatives","that","occur","at","very","low","concentrations","in","plant","tissues","and","may","have","hormone-like","effects","."),4029250). assertion_content_comment('tOboGo_BrassinosteroidSulfotransferaseActivity',s("Catalysis","of","the","transfer","of","a","sulfate","group","from","3","'","-phosphoadenosine","5","'","-phosphosulfate","to","the","hydroxyl","group","of","a","brassinosteroid","acceptor",",","producing","the","sulfated","brassinosteroid","derivative","and","3","'","-phosphoadenosine","5","'","-phosphate","."),4181667). assertion_content_comment('tOboGo_BREBinding',s("Interacting","selectively","and","non-covalently","with","the","RNA","element","BRE","(","Bruno","response","element",")"),4315264). assertion_content_comment('tOboGo_BridgeContactSite',s("Site","of","contact","between","the","inner","and","outer","mitochondrial","membrane","found","in","neuronal","mitochondria",";","may","play","a","role","in","maintaining","the","structural","integrity","of","the","inner","and","outer","boundary","membranes","."),4288169). assertion_content_comment('tOboGo_BRISCComplex',s("A","protein","complex","that","contains","the","FAM175B/ABRO1",",","BRCC3/BRCC36",",","BRE/BRCC45","and","MERIT40/NBA1","proteins",",","and","specifically","cleaves","K63-linked","polyubiquitin","chains","."),4174651). assertion_content_comment('tOboGo_BristleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","bristle","over","time",",","from","its","formation","to","the","mature","structure",".","A","bristle","is","an","insect","sensory","organ","."),4020821). assertion_content_comment('tOboGo_BristleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","bristle","are","generated","and","organized","."),4020831). assertion_content_comment('tOboGo_BromidePeroxidaseActivity',s("Catalysis","of","the","reaction",":","2","R-H","+","2","bromide","+","hydrogen","peroxide","=","2","R-Br","+","2","H2O",".","Enzymes","with","this","activity","often","accept","other","halide","ions","as","substrates",",","including","chloride","and","iodide","."),4233401). assertion_content_comment('tOboGo_BromoxynilMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","bromoxynil",",","C7H3Br2NO",",","a","dibrominated","phenol","derivative","with","a","cyano","(","-CN",")","group","attached",".","Bromoxynil","is","used","as","a","herbicide","for","post-emergent","control","of","annual","broadleaf","weeds","and","works","by","inhibiting","photosynthesis","in","the","target","plants","."),4273428). assertion_content_comment('tOboGo_BromoxynilNitrilaseActivity',s("Catalysis","of","the","reaction",":","3",",","5-dibromo-4-hydroxybenzonitrile","+","2","H","(","2",")","O","=","3",",","5-dibromo-4-hydroxybenzoate","+","NH","(","4",")","(","+",")","Involved","in","the","bacterial","degradation","of","the","herbicide","bromoxynil","."),4274610). assertion_content_comment('tOboGo_BronchioleDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","bronchiole","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","bronchiole","and","ends","with","the","mature","structure",".","A","bronchiole","is","the","first","airway","branch","that","no","longer","contains","cartilage",";","it","is","a","branch","of","the","bronchi","."),4117253). assertion_content_comment('tOboGo_BronchioleMorphogenesis',s("The","process","in","which","a","bronchiole","is","generated","and","organized",".","A","bronchiole","is","the","first","airway","branch","that","no","longer","contains","cartilage",";","it","is","a","branch","of","the","bronchi","."),4117283). assertion_content_comment('tOboGo_BronchusCartilageDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","lung","cartilage","over","time",",","from","its","formation","to","the","mature","structure",".","Cartilage","is","a","connective","tissue","dominated","by","extracellular","matrix","containing","collagen","type","II","and","large","amounts","of","proteoglycan",",","particularly","chondroitin","sulfate","."),4116230). assertion_content_comment('tOboGo_BronchusCartilageMorphogenesis',s("The","process","in","which","the","bronchus","cartilage","is","generated","and","organized",".","The","bronchus","cartilage","is","the","connective","tissue","of","the","portion","of","the","airway","that","connects","to","the","lungs","."),4116252). assertion_content_comment('tOboGo_BronchusDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","bronchus","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","bronchus","and","ends","with","the","mature","structure",".","The","bronchus","is","the","portion","of","the","airway","that","connects","to","the","lungs","."),4116221). assertion_content_comment('tOboGo_BronchusMorphogenesis',s("The","process","in","which","the","bronchus","is","generated","and","organized",".","The","bronchus","is","the","portion","of","the","airway","that","connects","to","the","lungs","."),4116249). assertion_content_comment('tOboGo_BrownFatCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","brown","adipocyte",",","an","animal","connective","tissue","cell","involved","in","adaptive","thermogenesis",".","Brown","adipocytes","contain","multiple","small","droplets","of","triglycerides","and","a","high","number","of","mitochondria","."),4150637). assertion_content_comment('tOboGo_BrownFatCellProliferation',s("The","multiplication","or","reproduction","of","brown","fat","cells","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","A","brown","fat","cell","is","a","fat","cell","found","the","thermogenic","form","of","adipose","tissue","found","in","newborns","of","many","species","."),4136721). assertion_content_comment('tOboGo_BrushBorderMembrane',s("The","portion","of","the","plasma","membrane","surrounding","the","brush","border","."),4060683). assertion_content_comment('tOboGo_BrushBorder',s("Dense","covering","of","microvilli","on","the","apical","surface","of","epithelial","cells","in","tissues","such","as","the","intestine",",","kidney",",","and","choroid","plexus",";","the","microvilli","aid","absorption","by","increasing","the","surface","area","of","the","cell","."),4060673). assertion_content_comment('tOboGo_BubbleDNABinding',s("Interacting","selective","with","DNA","that","contains","a","bubble",".","A","bubble","occurs","when","DNA","contains","a","region","of","unpaired",",","single-stranded","DNA","flanked","on","both","sides","by","regions","of","paired",",","double-stranded","DNA","."),4362830). assertion_content_comment('tOboGo_BudDilationInvolvedInLungBranching',s("The","process","in","which","a","bud","in","the","lung","increases","radially","."),4116660). assertion_content_comment('tOboGo_BudDilation',s("The","process","in","which","a","branch","bud","increases","radially",".","A","branch","bud","is","the","initial","area","of","outgrowth","in","the","formation","of","a","new","branch","."),4135678). assertion_content_comment('tOboGo_BuddingCellApicalBudGrowth',s("Growth","at","the","tip","of","a","bud",",","in","a","cell","that","reproduces","by","budding","."),4027345). assertion_content_comment('tOboGo_BuddingCellBudGrowth',s("The","process","in","which","the","bud","portion","of","a","cell","that","reproduces","by","budding","irreversibly","increases","in","size","over","time","by","accretion","and","biosynthetic","production","of","matter","similar","to","that","already","present","."),4011819). assertion_content_comment('tOboGo_BuddingCellIsotropicBudGrowth',s("Unlocalized","bud","growth","such","that","the","entire","surface","of","the","bud","expands","evenly",",","in","a","cell","that","reproduces","by","budding","."),4236037). assertion_content_comment('tOboGo_BudElongationInvolvedInLungBranching',s("The","process","in","which","a","bud","in","the","lung","grows","out","from","the","point","where","it","is","formed","."),4117735). assertion_content_comment('tOboGo_BudFieldSpecification',s("The","regionalization","process","in","which","the","identity","of","a","bud","primordium","is","specified",".","Identity","is","considered","to","be","the","aggregate","of","characteristics","by","which","a","structure","is","recognized","."),4135668). assertion_content_comment('tOboGo_BudOutgrowthInvolvedInLungBranching',s("The","process","in","which","a","region","of","the","lung","epithelium","initiates","an","outgrowth","."),4117293). assertion_content_comment('tOboGo_BudScarAccumulation',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236113). assertion_content_comment('tOboGo_BudSiteSelectionEstablishmentOfCellPolaritySensuSaccharomyces',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236072). assertion_content_comment('tOboGo_BulbusArteriosusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","bulbus","arteriosus","over","time",",","from","its","formation","to","the","mature","structure",".","The","bulbus","arteriosus","is","an","elastic","heart","chamber","."),4002635). assertion_content_comment('tOboGo_BulbusArteriosusFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","bulbus","arteriosus","from","unspecified","parts",".","The","bulbus","arteriosus","is","an","elastic","chamber","of","the","heart","."),4002655). assertion_content_comment('tOboGo_BulbusArteriosusMorphogenesis',s("The","process","in","which","the","bulbus","arteriosus","is","generated","and","organized",".","The","bulbus","arteriosus","is","an","elastic","cardiac","chamber","."),4002645). assertion_content_comment('tOboGo_BundleOfHisDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","bundle","of","His","over","time",",","from","its","formation","to","the","mature","structure",".","The","bundle","of","His","is","part","of","the","His-Purkinje","system","that","transmits","signals","from","the","AV","node","to","the","cardiac","Purkinje","fibers","."),4003745). assertion_content_comment('tOboGo_BursaOfFabriciusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","bursa","of","Fabricius","over","time",",","from","its","formation","to","the","mature","structure",".","The","bursa","of","Fabricius","is","an","organ","found","in","birds","involved","in","B","cell","differentiation","."),4332362). assertion_content_comment('tOboGo_BursiconNeuropeptideHormoneComplex',s("A","neuropeptide","hormone","secreted","by","the","central","nervous","system","of","insects","that","stimulates","the","tanning","and","sclerotization","of","the","adult","cuticle","following","eclosion",".","The","active","hormone","consists","of","an","obligate","heterodimer","of","the","alpha","and","beta","subunits","."),4058609). assertion_content_comment('tOboGo_ButanalDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","butanal","+","CoA","+","NAD","(","P",")","+","=","butanoyl-CoA","+","NAD","(","P",")","H","+","H","+"),4373121). assertion_content_comment('tOboGo_ButanediolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","butanediol",";","the","biologically","relevant","isomer","is","2",",","3-butanediol",",","CH3CH","(","OH",")","CH","(","OH",")","CH3","."),4361227). assertion_content_comment('tOboGo_ButanediolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","butanediol",";","the","biologically","relevant","isomer","is","2",",","3-butanediol",",","CH3CH","(","OH",")","CH","(","OH",")","CH3","."),4361244). assertion_content_comment('tOboGo_ButanediolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","butanediol",";","the","biologically","relevant","isomer","is","2",",","3-butanediol",",","CH3CH","(","OH",")","CH","(","OH",")","CH3","."),4244328). assertion_content_comment('tOboGo_ButaneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","cyclohexane","+","O2","+","NAD","(","P",")","H","+","H","+","=","cyclohexanol","+","NAD","(","P",")","+","+","H2O","."),4349879). assertion_content_comment('tOboGo_ButanoyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","butanoyl","(","CH3-","[","CH2","]","2-CO-",")","group","to","an","acceptor","molecule","."),4355299). assertion_content_comment('tOboGo_ButyrateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","butyrate",",","the","anion","of","butyric","acid","."),4316541). assertion_content_comment('tOboGo_ButyrateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","butyrate",",","the","anion","of","butyric","acid","."),4243658). assertion_content_comment('tOboGo_ButyrateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","butanoate","=","ADP","+","butanoyl","phosphate","+","H","(","+",")"),4373063). assertion_content_comment('tOboGo_ButyrateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","butyrate",",","the","anions","of","butyric","acid","(","butanoic","acid",")",",","a","saturated",",","unbranched","aliphatic","acid","."),4243636). assertion_content_comment('tOboGo_ButyrolactoneHydrolaseActivity',s("Catalysis","of","the","reaction",":","butyrolactone","+","H2O","=","4-hydroxybutanoate","."),4275020). assertion_content_comment('tOboGo_C2H2ZincFingerDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","C2H2-type","zinc","finger","domain","of","a","protein",".","The","C2H2","zinc","finger","is","the","classical","zinc","finger","domain",",","in","which","two","conserved","cysteines","and","histidines","co-ordinate","a","zinc","ion","."),4176164). assertion_content_comment('tOboGo_C3aAnaphylatoxinReceptorActivity',s("Combining","with","anaphylatoxin","C3a","to","initiate","a","change","in","cell","activity","."),4197918). assertion_content_comment('tOboGo_C4Photosynthesis',s("The","combination","of","atmospheric","CO2","with","a","3-carbon","molecule","phosphoenol","pyruvate","(","PEP",")","in","the","mesophyll","cells","to","make","a","4-carbon","acid","which","is","immediately","converted","to","malic","acid",".","The","malic","acid","is","then","passed","across","to","the","bundle","sheath","cells","where","it","is","broken","down","again","to","pyruvic","acid","and","CO2",".","The","acid","is","passed","back","to","the","mesophyll","cells","to","be","used","again",",","while","the","CO2","is","fed","into","the","reductive","pentose-phosphate","cycle","(","Calvin","cycle",")","and","converted","into","sugar","and","starch","."),4262747). assertion_content_comment('tOboGo_C5aAnaphylatoxinChemotacticReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","C5a","anaphylatoxin","chemotactic","receptor","."),4323155). assertion_content_comment('tOboGo_C5aAnaphylatoxinReceptorActivity',s("Combining","with","anaphylatoxin","C5a","to","initiate","a","change","in","cell","activity","."),4197945). assertion_content_comment('tOboGo_C5L2AnaphylatoxinChemotacticReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","C5L2","anaphylatoxin","chemotactic","receptor","."),4323158). assertion_content_comment('tOboGo_CadaverineAminopropyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosylmethioninamine","+","cadaverine","=","5","'","-methylthioadenosine","+","N-","(","3-aminopropyl",")","cadaverine","."),4328631). assertion_content_comment('tOboGo_CadaverineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","cadaverine",",","1",",","5-pentanediamine",",","from","one","side","of","the","membrane","to","the","other","."),4292327). assertion_content_comment('tOboGo_CadaverineTransport',s("The","directed","movement","of","cadaverine",",","1",",","5-pentanediamine",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4294107). assertion_content_comment('tOboGo_CadherinBinding',s("Interacting","selectively","and","non-covalently","with","cadherin",",","a","type","I","membrane","protein","involved","in","cell","adhesion","."),4298696). assertion_content_comment('tOboGo_CadmiumIonBinding',s("Interacting","selectively","and","non-covalently","with","cadmium","(","Cd",")","ions","."),4218563). assertion_content_comment('tOboGo_CadmiumIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","cadmium","ions","within","an","organism","or","cell","."),4222121). assertion_content_comment('tOboGo_CadmiumIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","cadmium","(","Cd",")","ions","from","one","side","of","a","membrane","to","the","other","."),4252781). assertion_content_comment('tOboGo_CadmiumIonTransmembraneTransport',s("A","process","in","which","a","cadmium","ion","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4175251). assertion_content_comment('tOboGo_CadmiumIonTransport',s("The","directed","movement","of","cadmium","(","Cd",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4175247). assertion_content_comment('tOboGo_CadmiumSensitivityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4233846). assertion_content_comment('tOboGo_CaffeineOxidaseActivity',s("Catalysis","of","the","reaction",":","caffeine","+","O2","+","2","H","+","+","2","e-","=","1",",","3",",","7-trimethyluric","acid","+","H2O","."),4350983). assertion_content_comment('tOboGo_CajalBodyOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","Cajal","bodies",",","nuclear","bodies","that","appear","ultrastructurally","as","a","tangle","of","coiled",",","electron-dense","threads","roughly","0.5","micrometers","in","diameter","and","are","enriched","in","ribonucleoproteins",",","and","certain","general","RNA","polymerase","II","transcription","factors","."),4307785). assertion_content_comment('tOboGo_CajalBody',s("A","class","of","nuclear","body",",","first","seen","after","silver","staining","by","Ramon","y","Cajal","in","1903",",","enriched","in","small","nuclear","ribonucleoproteins",",","and","certain","general","RNA","polymerase","II","transcription","factors",";","ultrastructurally",",","they","appear","as","a","tangle","of","coiled",",","electron-dense","threads","roughly","0.5","micrometers","in","diameter",";","involved","in","aspects","of","snRNP","biogenesis",";","the","protein","coilin","serves","as","a","marker","for","Cajal","bodies",".","Some","argue","that","Cajal","bodies","are","the","sites","for","preassembly","of","transcriptosomes",",","unitary","particles","involved","in","transcription","and","processing","of","RNA","."),4126609). assertion_content_comment('tOboGo_CalcineurinComplex',s("A","heterodimeric","calcium","ion","and","calmodulin","dependent","protein","phosphatase","composed","of","catalytic","and","regulatory","subunits",";","the","regulatory","subunit","is","very","similar","in","sequence","to","calmodulin","."),4221215). assertion_content_comment('tOboGo_CalcitoninBinding',s("Interacting","selectively","and","non-covalently","with","calcitonin",",","a","peptide","hormone","responsible","for","reducing","serum","calcium","levels","by","inhibiting","osteoclastic","bone","reabsorption","and","promoting","renal","calcium","excretion",".","It","is","synthesized","and","released","by","the","C","cells","of","the","thyroid","."),4337274). assertion_content_comment('tOboGo_CalcitoninCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","peptide","calcitonin","."),4335938). assertion_content_comment('tOboGo_CalcitoninReceptorActivity',s("Combining","with","calcitonin","to","initiate","a","change","in","cell","activity","."),4197681). assertion_content_comment('tOboGo_CalcitoninReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","calcitonin","receptor","."),4323168). assertion_content_comment('tOboGo_CalciumActivatedCationChannelActivity',s("Catalysis","of","the","calcium","concentration-regulatable","energy-independent","passage","of","cations","across","a","lipid","bilayer","down","a","concentration","gradient","."),4159394). assertion_content_comment('tOboGo_Calcium_CationAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Ca2","+","(","in",")","+","cation","(","out",")","=","Ca2","+","(","out",")","+","cation","(","in",")"),4219616). assertion_content_comment('tOboGo_CalciumChannelActivity',s("Catalysis","of","facilitated","diffusion","of","a","calcium","ion","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel","without","evidence","for","a","carrier-mediated","mechanism","."),4158429). assertion_content_comment('tOboGo_CalciumChannelInhibitorActivity',s("Stops",",","prevents",",","or","reduces","the","activity","of","a","calcium","channel","."),4233600). assertion_content_comment('tOboGo_CalciumChannelRegulatorActivity',s("Modulates","the","activity","of","a","calcium","channel","."),4218018). assertion_content_comment('tOboGo_Calcium_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Ca2","+","(","in",")","+","H","+","(","out",")","=","Ca2","+","(","out",")","+","H","+","(","in",")"),4295999). assertion_content_comment('tOboGo_CalciumIonBinding',s("Interacting","selectively","and","non-covalently","with","calcium","ions","(","Ca2","+",")"),4218578). assertion_content_comment('tOboGo_CalciumIonImport',s("The","directed","movement","of","calcium","ions","into","a","cell","or","organelle","."),4151700). assertion_content_comment('tOboGo_CalciumIonStorageActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218605). assertion_content_comment('tOboGo_CalciumIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","calcium","(","Ca",")","ions","from","one","side","of","a","membrane","to","the","other","."),4216750). assertion_content_comment('tOboGo_CalciumIonTransmembraneTransport',s("A","process","in","which","a","calcium","ion","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4151697). assertion_content_comment('tOboGo_CalciumIonTransportIntoCytosol',s("The","directed","movement","of","calcium","ions","(","Ca2","+",")","into","the","cytosol","."),4029723). assertion_content_comment('tOboGo_CalciumOxalateBinding',s("Interacting","selectively","and","non-covalently","with","calcium","oxalate",",","CaC2O4",",","a","salt","of","oxalic","acid",".","In","animals",",","it","may","be","excreted","in","urine","or","retained","in","the","form","of","urinary","calculi","."),4358564). assertion_content_comment('tOboGo_CalciumPotassium_SodiumAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Ca2","+","(","in",")","+","K","+","(","in",")","+","Na","+","(","out",")","=","Ca2","+","(","out",")","+","K","+","(","out",")","+","Na","+","(","in",")"),4256252). assertion_content_comment('tOboGo_CalciumSensitiveGuanylateCyclaseActivatorActivity',s("Increases","the","activity","of","guanylate","cyclase","in","response","to","a","change","in","calcium","ion","concentration","."),4246868). assertion_content_comment('tOboGo_Calcium_SodiumAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Ca2","+","(","in",")","+","Na","+","(","out",")","=","Ca2","+","(","out",")","+","Na","+","(","in",")"),4219618). assertion_content_comment('tOboGo_CaldesmonKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","caldesmon","=","ADP","+","caldesmon","phosphate","."),4373052). assertion_content_comment('tOboGo_CalloseBinding',s("Interacting","selectively","and","non-covalently","with","callose",".","Callose","is","a","linear","1",",","3-beta-D-glucan","formed","from","UDP-glucose","and","is","found","in","certain","plant","cell","walls","."),4182518). assertion_content_comment('tOboGo_CalloseDepositionInCellWall',s("Any","process","in","which","callose","is","transported","to",",","and/or","maintained","in",",","the","cell","wall",".","Callose","is","a","linear","1",",","3-beta-d-glucan","formed","from","UDP-glucose","and","is","found","in","certain","plant","cell","walls","."),4185410). assertion_content_comment('tOboGo_CalloseDepositionInPhloemSievePlate',s("Any","process","in","which","callose","is","transported","to",",","and/or","maintained","in",",","phloem","sieve","plate",".","Callose","is","a","linear","1",",","3-beta-d-glucan","formed","from","UDP-glucose","and","is","found","in","certain","plant","cell","walls","."),4181249). assertion_content_comment('tOboGo_CalloseLocalization',s("Any","process","in","which","callose","is","transported","to",",","and/or","maintained","in",",","a","specific","location",".","Callose","is","a","linear","1",",","3-beta-d-glucan","formed","from","UDP-glucose","and","is","found","in","certain","plant","cell","walls","."),4138585). assertion_content_comment('tOboGo_CalmodulinBinding',s("Interacting","selectively","and","non-covalently","with","calmodulin",",","a","calcium-binding","protein","with","many","roles",",","both","in","the","calcium-bound","and","calcium-free","states","."),4218615). assertion_content_comment('tOboGo_CalmodulinInhibitorActivity',s("OBSOLETE",".","This","term","was","not","defined","before","being","made","obsolete","."),4218626). assertion_content_comment('tOboGo_CalpainInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","the","enzyme","calpain",",","which","catalyzes","of","the","preferential","cleavage","of","Tyr-Xaa",",","Met-Xaa","or","Arg-Xaa","with","Leu","or","Val","as","the","P2","residue","."),4311257). assertion_content_comment('tOboGo_CalyxOfHeld',s("The","terminal","specialization","of","a","calyciferous","axon","which","forms","large","synapses","in","the","mammalian","auditory","central","nervous","system","."),4287892). assertion_content_comment('tOboGo_CamalexinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","camalexin",",","an","indole","phytoalexin","."),4334525). assertion_content_comment('tOboGo_CamalexinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","camalexin",",","an","indole","phytoalexin","."),4197031). assertion_content_comment('tOboGo_CAMPBinding',s("Interacting","selectively","and","non-covalently","with","cAMP",",","the","nucleotide","cyclic","AMP","(","adenosine","3","'",",","5","'","-cyclophosphate",")"),4310766). assertion_content_comment('tOboGo_CAMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4027715). assertion_content_comment('tOboGo_CAMPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4050066). assertion_content_comment('tOboGo_CAMPGeneratingPeptideActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4254486). assertion_content_comment('tOboGo_CAMPhotosynthesis',s("The","combination","of","atmospheric","CO2","with","a","3-carbon","molecule","phosphoenol","pyruvate","(","PEP",")","to","make","malic","acid",".","The","malic","acid","is","then","passed","into","the","vacuole","where","it","is","stored","until","daylight",",","when","it","is","shuttled","back","out","to","be","used","as","a","substrate","in","the","light","reaction","of","photosynthesis","."),4262759). assertion_content_comment('tOboGo_CAMPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","nucleotide","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")"),4027649). assertion_content_comment('tOboGo_CAMPReceptorActivity',s("Combining","with","cAMP","(","cyclic","AMP",",","adenosine","3","'",",","5","'","-cyclophosphate",")","to","initiate","a","change","in","cell","activity","."),4384021). assertion_content_comment('tOboGo_CAMPResponseElementBindingProteinBinding',s("Interacting","selectively","and","non-covalently","with","the","cAMP","response","element","binding","protein","."),4245749). assertion_content_comment('tOboGo_CAMPResponseElementBinding',s("Interacting","selectively","and","non-covalently","with","the","cyclic","AMP","response","element","(","CRE",")",",","a","short","palindrome-containing","sequence","found","in","the","promoters","of","genes","whose","expression","is","regulated","in","response","to","cyclic","AMP","."),4376877). assertion_content_comment('tOboGo_CAMPTransport',s("The","directed","movement","of","cyclic","AMP","(","cAMP",")",",","into",",","out","of","or","within","a","cell","."),4176264). assertion_content_comment('tOboGo_CanalicularBileAcidTransmembraneTransporterActivity',s("The","directed","movement","of","bile","acid","and","bile","salts","out","of","a","hepatocyte","and","into","the","bile","canaliculus","by","means","of","an","agent","such","as","a","transporter","or","pore",".","Bile","canaliculi","are","the","thin","tubes","formed","by","hepatocyte","membranes",".","Bile","acids","are","any","of","a","group","of","steroid","carboxylic","acids","occurring","in","bile",",","where","they","are","present","as","the","sodium","salts","of","their","amides","with","glycine","or","taurine","."),4297358). assertion_content_comment('tOboGo_CanalicularBileAcidTransport',s("Catalysis","of","the","transfer","of","bile","acid","from","one","side","of","a","hepatocyte","plasma","membrane","into","a","bile","canaliculus",".","Bile","canaliculi","are","the","thin","tubes","formed","by","hepatocyte","membranes",".","Bile","acids","are","any","of","a","group","of","steroid","carboxylic","acids","occurring","in","bile",",","where","they","are","present","as","the","sodium","salts","of","their","amides","with","glycine","or","taurine","."),4290622). assertion_content_comment('tOboGo_CandelabrumCellDifferentiation',s("The","process","in","which","neuroblasts","acquire","specialized","structural","and/or","functional","features","that","characterize","the","mature","candelabrum","cell",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","neuroblast","to","a","candelabrum","cell","fate",".","A","candelabrum","cell","is","an","inhibitory","GABAergic","interneuron","found","in","the","cerebellar","cortex","."),4043396). assertion_content_comment('tOboGo_CannabinoidReceptorActivity',s("Combining","with","cannabinoids","to","initiate","a","change","in","cell","activity","."),4197690). assertion_content_comment('tOboGo_CannabinoidReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","cannabinoid","receptor","."),4323125). assertion_content_comment('tOboGo_CanonicalHolinActivity',s("Catalysis","of","the","temporally-regulated","formation","of","a","non-specific","transmembrane","protein","hole","that","allows","release","of","a","fully-folded","phage-encoded","endolysin","(","murein-degradase",")","from","the","cell","."),4360139). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInCardiacMuscleCellFateCommitment',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes",".","In","this","pathway",",","the","activated","receptor","signals","via","downstream","effectors","that","result","in","the","inhibition","of","beta-catenin","phosphorylation",",","thereby","preventing","degradation","of","beta-catenin","and","contributing","to","cardiac","muscle","cell","fate","commitment",".","Stabilized","beta-catenin","can","then","accumulate","and","travel","to","the","nucleus","to","trigger","changes","in","transcription","of","target","genes","."),4134884). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInCardiacNeuralCrestCellDifferentiationInvolvedInHeartDevelopment',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","cardiac","neural","crest","cell","differentiation","."),4134861). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInHeartDevelopment',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","contributes","to","the","progression","of","the","heart","over","time",".","In","this","pathway",",","the","activated","receptor","signals","via","downstream","effectors","that","result","in","the","inhibition","of","beta-catenin","phosphorylation",",","thereby","preventing","degradation","of","beta-catenin",".","Stabilized","beta-catenin","can","then","accumulate","and","travel","to","the","nucleus","to","trigger","changes","in","transcription","of","target","genes","."),4001108). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInMesenchymalStemCellDifferentiation',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","mesenchymal","stem","cell","differentiation","."),4096700). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInMesonephricNephronDevelopment',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","contribute","to","the","progression","of","the","mesonephric","nephron","over","time",".","In","this","pathway",",","the","activated","receptor","signals","via","downstream","effectors","that","result","in","the","inhibition","of","beta-catenin","phosphorylation",",","thereby","preventing","degradation","of","beta-catenin",".","Stabilized","beta-catenin","can","then","accumulate","and","travel","to","the","nucleus","to","trigger","changes","in","transcription","of","target","genes","."),4134731). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInMesonephrosDevelopment',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","contributes","to","the","progression","of","the","mesonephros","over","time",".","In","this","pathway",",","the","activated","receptor","signals","via","downstream","effectors","that","result","in","the","inhibition","of","beta-catenin","phosphorylation",",","thereby","preventing","degradation","of","beta-catenin",".","Stabilized","beta-catenin","can","then","accumulate","and","travel","to","the","nucleus","to","trigger","changes","in","transcription","of","target","genes","."),4134727). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInMetanephricKidneyDevelopment',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","contribute","to","the","progression","of","the","metanephric","kidney","over","time",".","In","this","pathway",",","the","activated","receptor","signals","via","downstream","effectors","that","result","in","the","inhibition","of","beta-catenin","phosphorylation",",","thereby","preventing","degradation","of","beta-catenin",".","Stabilized","beta-catenin","can","then","accumulate","and","travel","to","the","nucleus","to","trigger","changes","in","transcription","of","target","genes","."),4134750). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInNegativeRegulationOfApoptosis',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","the","negative","regulation","of","apoptosis","."),4096744). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInNeuralCrestCellDifferentiation',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","neural","crest","cell","differentiation","."),4096733). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInNeuralPlateAnteriorPosteriorPatternFormation',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","contributes","to","the","formation","of","the","neural","plate","anterior/posterior","pattern","."),4111301). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInOsteoblastDifferentiation',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","osteoblast","differentiation","."),4096711). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInPositiveRegulationOfApoptosis',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","the","positive","regulation","of","apoptosis","."),4096680). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInPositiveRegulationOfCardiacMuscleCellProliferation',s("The","canonical","Wnt","receptor","signaling","pathway","that","contributes","to","an","expansion","of","the","population","of","cardiac","muscle","cells","."),4134873). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInPositiveRegulationOfCardiacOutflowTractCellProliferation',s("The","canonical","Wnt","receptor","signaling","pathway","that","contributes","to","the","modulation","of","the","expansion","of","a","population","of","cardiac","outflow","tract","cells","."),4134907). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInPositiveRegulationOfEndothelialCellMigration',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","the","positive","regulation","of","endothelial","cell","migration","."),4096790). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInPositiveRegulationOfEpithelialToMesenchymalTransition',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","the","positive","regulation","of","epithelial","cell","to","mesenchymal","cell","transition","."),4096722). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInPositiveRegulationOfSecondaryHeartFieldCardioblastProliferation',s("The","series","of","molecular","signals","initiated","by","binding","of","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","a","target","cell","resulting","in","an","increase","in","the","frequency",",","or","rate","of","cardioblast","proliferation",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4001112). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInPositiveRegulationOfWoundHealing',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","involved","in","positive","regulation","of","wound","healing","."),4096843). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInRegulationOfCellProliferation',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","contributes","to","modulating","the","rate","or","frequency","of","cell","proliferation","."),4001074). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInRegulationOfTypeBPancreaticCellProliferation',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","modulates","the","rate","or","frequency","of","pancreatic","B","cell","proliferation",".","Pancreatic","B","cell","are","cells","of","the","pancreas","that","secrete","insulin","."),4096765). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathwayInvolvedInUretericBudBranching',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes","that","contributes","to","the","branching","of","the","ureteric","bud",".","In","this","pathway",",","the","activated","receptor","signals","via","downstream","effectors","that","result","in","the","inhibition","of","beta-catenin","phosphorylation",",","thereby","preventing","degradation","of","beta-catenin",".","Stabilized","beta-catenin","can","then","accumulate","and","travel","to","the","nucleus","to","trigger","changes","in","transcription","of","target","genes","."),4134754). assertion_content_comment('tOboGo_CanonicalWntReceptorSignalingPathway',s("The","series","of","molecular","signals","initiated","by","binding","of","a","Wnt","protein","to","a","frizzled","family","receptor","on","the","surface","of","the","target","cell",",","followed","by","propagation","of","the","signal","via","beta-catenin",",","and","ending","with","a","change","in","transcription","of","target","genes",".","In","this","pathway",",","the","activated","receptor","signals","via","downstream","effectors","that","result","in","the","inhibition","of","beta-catenin","phosphorylation",",","thereby","preventing","degradation","of","beta-catenin",".","Stabilized","beta-catenin","can","then","accumulate","and","travel","to","the","nucleus","to","trigger","changes","in","transcription","of","target","genes","."),4001067). assertion_content_comment('tOboGo_CaprolactamCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","caprolactam",",","hexahydro-2h-azepin-2-one",",","a","cyclic","amide","of","caproic","acid","."),4239829). assertion_content_comment('tOboGo_CaprolactamMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","caprolactam",",","hexahydro-2h-azepin-2-one",",","a","cyclic","amide","of","caproic","acid","used","in","manufacture","of","synthetic","fibers","of","the","polyamide","type",".","It","can","cause","local","irritation","."),4239824). assertion_content_comment('tOboGo_CapsanthinCapsorubinSynthaseActivity',s("Catalysis","of","the","reactions",":","violaxanthin","=","capsorubin",",","and","antheraxanthin","=","capsanthin","."),4361004). assertion_content_comment('tOboGo_Capsomere',s("Any","of","the","protein","subunits","that","comprise","the","closed","shell","or","coat","(","capsid",")","of","certain","viruses","."),4099266). assertion_content_comment('tOboGo_CapsularPolysaccharideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","capsular-polysaccharides","from","one","side","of","the","membrane","to","the","other",".","Capsular","polysaccharides","make","up","the","capsule",",","a","protective","structure","surrounding","some","species","of","bacteria","and","fungi","."),4291950). assertion_content_comment('tOboGo_CapsularPolysaccharideTransport',s("The","directed","movement","of","capsular","polysaccharides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Capsular","polysaccharides","make","up","the","capsule",",","a","protective","structure","surrounding","some","species","of","bacteria","and","fungi","."),4291281). assertion_content_comment('tOboGo_CapsuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","capsule",",","a","protective","structure","surrounding","some","species","of","bacteria","and","fungi","."),4174902). assertion_content_comment('tOboGo_CapsulePolysaccharideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","polysaccharides","that","make","up","the","capsule",",","a","protective","structure","surrounding","some","species","of","bacteria","and","fungi","."),4298930). assertion_content_comment('tOboGo_Capsule',s("A","protective","structure","surrounding","some","fungi","and","bacteria",",","attached","externally","to","the","cell","wall","and","composed","primarily","of","polysaccharides",".","Capsules","are","highly","organized","structures","that","adhere","strongly","to","cells","and","can","not","be","easily","removed",".","Capsules","play","important","roles","in","pathogenicity",",","preventing","phagocytosis","by","other","cells",",","adherance",",","and","resistance","to","dessication","."),4316387). assertion_content_comment('tOboGo_CarbamateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","NH3","+","CO2","=","ADP","+","carbamoyl","phosphate","."),4250562). assertion_content_comment('tOboGo_CarbamateResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4245960). assertion_content_comment('tOboGo_CarbamateSusceptibilityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4304392). assertion_content_comment('tOboGo_CarbamoylPhosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","carbamoyl","phosphate",",","an","intermediate","in","the","urea","cycle","and","other","nitrogen","compound","metabolic","pathways","."),4175660). assertion_content_comment('tOboGo_CarbamoylPhosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carbamoyl","phosphate",",","an","intermediate","in","the","urea","cycle","and","other","nitrogen","compound","metabolic","pathways","."),4175648). assertion_content_comment('tOboGo_CarbazoleBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","carbazole",",","a","heterocyclic","aromatic","compound","containing","a","dibenzopyrrole","system","that","is","produced","during","coal","gasification","and","is","present","in","cigarette","smoke",".","Coal","tar","produced","at","high","temperature","contains","an","average","of","1.5","%","carbazole",".","It","is","used","widely","in","synthesis","of","dyes",",","pharmaceuticals",",","and","plastics","and","is","a","suspected","carcinogen","."),4354002). assertion_content_comment('tOboGo_CarbazoleCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carbazole",",","a","heterocyclic","aromatic","compound","containing","a","dibenzopyrrole","system","that","is","produced","during","coal","gasification","and","is","present","in","cigarette","smoke",".","Coal","tar","produced","at","high","temperature","contains","an","average","of","1.5","%","carbazole",".","It","is","used","widely","in","synthesis","of","dyes",",","pharmaceuticals",",","and","plastics","and","is","a","suspected","carcinogen","."),4354068). assertion_content_comment('tOboGo_CarbazoleMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carbazole",",","a","heterocyclic","aromatic","compound","containing","a","dibenzopyrrole","system","that","is","produced","during","coal","gasification","and","is","present","in","cigarette","smoke",".","Coal","tar","produced","at","high","temperature","contains","an","average","of","1.5","%","carbazole",".","It","is","used","widely","in","synthesis","of","dyes",",","pharmaceuticals",",","and","plastics","and","is","a","suspected","carcinogen","."),4273453). assertion_content_comment('tOboGo_CarbohydrateBinding',s("Interacting","selectively","and","non-covalently","with","any","carbohydrate",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y","."),4157723). assertion_content_comment('tOboGo_CarbohydrateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y","."),4009060). assertion_content_comment('tOboGo_CarbohydrateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y","."),4008824). assertion_content_comment('tOboGo_CarbohydrateExport',s("The","directed","movement","of","carbohydrates","out","of","a","cell","or","organelle","."),4337994). assertion_content_comment('tOboGo_CarbohydrateHomeostasis',s("A","homeostatic","process","involved","in","the","maintenance","of","an","internal","steady","state","of","a","carbohydrate","within","an","organism","or","cell","."),4081279). assertion_content_comment('tOboGo_CarbohydrateKinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","carbohydrate","substrate","molecule","."),4189637). assertion_content_comment('tOboGo_CarbohydrateLocalization',s("Any","process","in","which","a","carbohydrate","is","transported","to",",","or","maintained","in",",","a","specific","location",".","Carbohydrates","are","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y","."),4186526). assertion_content_comment('tOboGo_CarbohydrateMediatedSignaling',s("A","series","of","molecular","signals","mediated","by","the","detection","of","carbohydrate","."),4260331). assertion_content_comment('tOboGo_CarbohydrateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y",".","Includes","the","formation","of","carbohydrate","derivatives","by","the","addition","of","a","carbohydrate","residue","to","another","molecule","."),4008708). assertion_content_comment('tOboGo_CarbohydratePhosphataseActivity',s("Catalysis","of","the","reaction",":","carbohydrate","phosphate","+","H2O","=","carbohydrate","+","phosphate","."),4188912). assertion_content_comment('tOboGo_CarbohydratePhosphorylation',s("The","process","of","introducing","a","phosphate","group","into","a","carbohydrate",",","any","organic","compound","based","on","the","general","formula","Cx","(","H2O",")","y","."),4225205). assertion_content_comment('tOboGo_CarbohydrateResponseElementBinding',s("Interacting","selectively","and","non-covalently","with","the","carbohydrate","response","element","(","ChoRE",")","found","in","the","promoters","of","genes","whose","expression","is","regulated","in","response","to","carbohydrates",",","such","as","the","triglyceride","synthesis","genes","."),4378618). assertion_content_comment('tOboGo_CarbohydrateStorage',s("The","accumulation","and","maintenance","in","cells","or","tissues","of","carbohydrates",",","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y","."),4186529). assertion_content_comment('tOboGo_CarbohydrateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","carbohydrate","from","one","side","of","the","membrane","to","the","other","."),4020387). assertion_content_comment('tOboGo_CarbohydrateTransmembraneTransport',s("The","process","in","which","a","carbohydrate","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083067). assertion_content_comment('tOboGo_CarbohydrateTransport',s("The","directed","movement","of","carbohydrate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Carbohydrates","are","any","of","a","group","of","organic","compounds","based","of","the","general","formula","Cx","(","H2O",")","y","."),4033656). assertion_content_comment('tOboGo_CarbohydrateUtilization',s("A","series","of","processes","that","forms","an","integrated","mechanism","by","which","a","cell","or","an","organism","detects","the","depletion","of","primary","carbohydrate","sources",",","usually","glucose",",","and","then","activates","genes","to","scavenge","the","last","traces","of","the","primary","carbohydrate","source","and","to","transport","and","metabolize","alternate","carbohydrate","sources",".","The","utilization","process","begins","when","the","cell","or","organism","detects","carbohydrate","levels",",","includes","the","activation","of","genes","whose","products","detect",",","transport","or","metabolize","carbohydrates",",","and","ends","when","the","carbohydrate","is","incorporated","into","the","cell","or","organism","'","s","metabolism","."),4094658). assertion_content_comment('tOboGo_CarbonateDehydrataseActivity',s("Catalysis","of","the","reaction",":","H2CO3","=","CO2","+","H2O","."),4212429). assertion_content_comment('tOboGo_CarbonCataboliteActivationOfTranscriptionFromRNAPolymeraseIIPromoter',s("Any","process","involving","carbon","catabolites","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4362442). assertion_content_comment('tOboGo_CarbonCataboliteActivationOfTranscription',s("A","transcription","regulation","process","in","which","the","presence","of","one","carbon","source","leads","to","an","increase","in","the","frequency",",","rate",",","or","extent","of","transcription","of","specific","genes","involved","in","the","metabolism","of","other","carbon","sources","."),4298066). assertion_content_comment('tOboGo_CarbonCataboliteRegulationOfTranscriptionFromRNAPolymeraseIIPromoter',s("A","transcription","regulation","process","in","which","the","presence","of","one","carbon","source","leads","to","the","modulation","of","the","frequency",",","rate",",","or","extent","of","transcription",",","from","an","RNA","polymerase","II","promoter",",","of","specific","genes","involved","in","the","metabolism","of","other","carbon","sources","."),4362438). assertion_content_comment('tOboGo_CarbonCataboliteRegulationOfTranscription',s("A","transcription","regulation","process","in","which","the","presence","of","one","carbon","source","leads","to","the","modulation","of","the","frequency",",","rate",",","or","extent","of","transcription","of","specific","genes","involved","in","the","metabolism","of","other","carbon","sources","."),4298054). assertion_content_comment('tOboGo_CarbonCataboliteRepressionOfTranscriptionFromRNAPolymeraseIIPromoter',s("A","transcription","regulation","process","in","which","the","presence","of","one","carbon","source","leads","to","a","decrease","in","the","frequency",",","rate",",","or","extent","of","transcription",",","from","an","RNA","polymerase","II","promoter",",","of","specific","genes","involved","in","the","metabolism","of","other","carbon","sources","."),4362453). assertion_content_comment('tOboGo_CarbonCataboliteRepressionOfTranscription',s("A","transcription","regulation","process","in","which","the","presence","of","one","carbon","source","leads","to","a","decrease","in","the","frequency",",","rate",",","or","extent","of","transcription","of","specific","genes","involved","in","the","metabolism","of","other","carbon","sources",".","Carbon","catabolite","repression","is","a","mechanism","of","genetic","regulation","which","the","accumulation","of","catabolites","of","one","substance","in","the","cell","represses","the","formation","of","enzymes","that","contribute","to","the","catabolism","of","other","substances","."),4300519). assertion_content_comment('tOboGo_CarbonDioxideTransmembraneTransporterActivity',s("Enables","the","transfer","of","carbon","dioxide","(","CO2",")","from","one","side","of","a","membrane","to","the","other","."),4382968). assertion_content_comment('tOboGo_CarbonDioxideTransmembraneTransport',s("A","process","in","which","carbon","dioxide","(","CO2",")","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4382988). assertion_content_comment('tOboGo_CarbonDioxideTransport',s("The","directed","movement","of","carbon","dioxide","(","CO2",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4289937). assertion_content_comment('tOboGo_CarbonDisulfideOxygenaseActivity',s("Catalysis","of","the","reaction",":","carbon","disulfide","+","NADH","+","H","+","+","O2","=","[","S","]","+","H2O","+","NAD","+","+","carbonyl","sulfide","."),4276312). assertion_content_comment('tOboGo_CarbonFixation',s("A","metabolic","process","in","which","carbon","(","usually","derived","from","carbon","dioxide",")","is","incorporated","into","organic","compounds","(","usually","carbohydrates",")"),4044999). assertion_content_comment('tOboGo_CarbonMonoxideBinding',s("Interacting","selectively","and","non-covalently","with","carbon","monoxide","(","CO",")"),4180420). assertion_content_comment('tOboGo_CarbonMonoxideSensorActivity',s("Interacting","selectively","and","non-covalently","with","and","responding",",","e.g",".","by","conformational","change",",","to","changes","in","the","cellular","level","of","carbon","monoxide","(","CO",")"),4180423). assertion_content_comment('tOboGo_CarbonPhosphorusLyaseActivity',s("Catalysis","of","the","reaction",":","alkylphosphonic","acid","=","R-CH3","+","phosphate",".","Substrates","include","aminomethylphosphonic","acid","(","AMPA",")","(","forms","methylamine",")",",","dimethylphosphinic","acid","(","forms","methylphosphonic","acid",")",",","glyphosate","(","forms","sarcosine",")","and","methylphosphonic","acid","(","forms","phosphate",")"),4273513). assertion_content_comment('tOboGo_CarbonTetrachlorideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carbon","tetrachloride",",","a","toxic",",","carcinogenic","compound","which","is","used","as","a","general","solvent","in","industrial","degreasing","operations",".","It","is","also","used","as","grain","fumigant","and","a","chemical","intermediate","in","the","production","of","refrigerants","."),4239802). assertion_content_comment('tOboGo_CarbonTetrachlorideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carbon","tetrachloride",",","a","toxic",",","carcinogenic","compound","which","is","used","as","a","general","solvent","in","industrial","degreasing","operations",".","It","is","also","used","as","grain","fumigant","and","a","chemical","intermediate","in","the","production","of","refrigerants","."),4239798). assertion_content_comment('tOboGo_CarbonUtilization',s("A","series","of","processes","that","forms","an","integrated","mechanism","by","which","a","cell","or","an","organism","detects","the","depletion","of","primary","carbon","sources","and","then","activates","genes","to","scavenge","the","last","traces","of","the","primary","carbon","source","and","to","transport","and","metabolize","alternative","carbon","sources","such","as","carbon","dioxide","or","carbonic","acid",".","The","utilization","process","begins","when","the","cell","or","organism","detects","carbon","levels",",","includes","the","activation","of","genes","whose","products","detect",",","transport","or","metabolize","carbon-containing","substances",",","and","ends","when","carbon","is","incorporated","into","the","cell","or","organism","'","s","metabolism","."),4094639). assertion_content_comment('tOboGo_CarbonylReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","R-CHOH-R","'","+","NADP","+","=","R-CO-R","'","+","NADPH","+","H","+"),4212306). assertion_content_comment('tOboGo_CarbonylSulfideNitrogenaseActivity',s("Catalysis","of","the","reaction",":","carbonyl","sulfide","+","2","H","+","+","2","e-","=","hydrogen","sulfide","+","carbon","monoxide","."),4276678). assertion_content_comment('tOboGo_CarboxylateReductaseActivity',s("Catalysis","of","the","reaction",":","an","aldehyde","+","acceptor","+","H2O","=","a","carboxylate","+","reduced","acceptor","."),4374160). assertion_content_comment('tOboGo_CarboxylesteraseActivity',s("Catalysis","of","the","reaction",":","a","carboxylic","ester","+","H2O","=","an","alcohol","+","a","carboxylic","anion","."),4212278). assertion_content_comment('tOboGo_CarboxylicAcidBinding',s("Interacting","selectively","and","non-covalently","with","a","carboxylic","acid",",","any","organic","acid","containing","one","or","more","carboxyl","(","COOH",")","groups","or","anions","(","COO-",")"),4157066). assertion_content_comment('tOboGo_CarboxylicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","carboxylic","acids",",","any","organic","acid","containing","one","or","more","carboxyl","(","-COOH",")","groups","."),4014445). assertion_content_comment('tOboGo_CarboxylicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carboxylic","acids",",","any","organic","acid","containing","one","or","more","carboxyl","(","-COOH",")","groups","."),4057914). assertion_content_comment('tOboGo_CarboxylicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carboxylic","acids",",","any","organic","acid","containing","one","or","more","carboxyl","(","COOH",")","groups","or","anions","(","COO-",")"),3978982). assertion_content_comment('tOboGo_CarboxylicAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","carboxylic","acids","from","one","side","of","the","membrane","to","the","other",".","Carboxylic","acids","are","organic","acids","containing","one","or","more","carboxyl","(","COOH",")","groups","or","anions","(","COO-",")"),4158509). assertion_content_comment('tOboGo_CarboxylicAcidTransport',s("The","directed","movement","of","carboxylic","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Carboxylic","acids","are","organic","acids","containing","one","or","more","carboxyl","(","COOH",")","groups","or","anions","(","COO-",")"),3990604). assertion_content_comment('tOboGo_CarboxylicEsterHydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","a","carboxylic","ester","to","give","an","alcohol","and","a","carboxylate","."),4181644). assertion_content_comment('tOboGo_CarboxymethylenebutenolidaseActivity',s("Catalysis","of","the","reaction",":","4-carboxymethylenebut-2-en-4-olide","+","H2O","=","4","oxohex-2-enedioate","."),4250595). assertion_content_comment('tOboGo_CarboxymethylhydantoinaseActivity',s("Catalysis","of","the","reaction",":","L-5-carboxymethylhydantoin","+","H","(","2",")","O","=","N-carbamoyl-L-aspartate","+","H","(","+",")"),4374149). assertion_content_comment('tOboGo_CarboxymethyloxysuccinateLyaseActivity',s("Catalysis","of","the","reaction",":","carboxymethoxysuccinate","=","fumarate","+","glycolate","."),4374087). assertion_content_comment('tOboGo_CarboxypeptidaseAActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","peptidyl-L-amino","acid","+","H2O","=","peptide","+","L-amino","acid",".","Little","or","no","action","with","-Asp",",","-Glu",",","-Arg",",","-Lys","or","-Pro","."),4210555). assertion_content_comment('tOboGo_CarboxypeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","the","terminal","or","penultimate","peptide","bond","at","the","C-terminal","end","of","a","peptide","or","polypeptide","."),4168570). assertion_content_comment('tOboGo_CarboxypeptidaseAInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","the","enzyme","carboxypeptidase","A","."),4309937). assertion_content_comment('tOboGo_CarboxypeptidaseBActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","H2O","+","peptidyl-L-lysine","(","or","L-arginine",")","=","L-lysine","(","or","L-arginine",")","+","peptide",".","Preferential","release","of","a","C-terminal","lysine","or","arginine","amino","acid","."),4266841). assertion_content_comment('tOboGo_CarboxypeptidaseCActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","a","C-terminal","amino","acid","with","a","broad","specificity","."),4210470). assertion_content_comment('tOboGo_CarboxypeptidaseDActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","release","of","a","C-terminal","arginine","or","lysine","residue",".","Function","is","inhibited","by","diisopropyl","fluorophosphate","and","sensitive","to","thiol-blocking","reagents","."),4210489). assertion_content_comment('tOboGo_CarboxypeptidaseEActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","peptidyl-L-lysine","(","or","peptidyl-L-arginine",")","+","H2O","=","peptide","+","L-lysine","(","or","L-arginine",")","Function","is","activated","by","Co2","+","and","inhibited","by","1",",","10-phenanthroline","and","other","chelating","agents","."),4210569). assertion_content_comment('tOboGo_Carboxysome',s("An","organelle","found","in","the","Cyanobacteria","consisting","of","a","proteinaceous","coat","and","enzymes","for","the","fixation","of","carbon","dioxide","including","mechanisms","for","the","concentration","of","carbonate","to","increase","the","efficiency","of","fixation","under","low-carbon","dioxide","conditions","."),4321627). 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assertion_content_comment('tOboGo_CardiacMuscleFiberDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","cardiac","muscle","fiber","over","time",",","from","its","formation","to","the","mature","structure","."),4107404). assertion_content_comment('tOboGo_CardiacMuscleHypertrophyInResponseToStress',s("The","enlargement","or","overgrowth","of","all","or","part","of","the","heart","muscle","due","to","an","increase","in","size","(","not","length",")","of","individual","cardiac","muscle","fibers",",","without","cell","division","."),4321106). assertion_content_comment('tOboGo_CardiacMuscleHypertrophy',s("The","enlargement","or","overgrowth","of","all","or","part","of","the","heart","muscle","due","to","an","increase","in","size","of","cardiac","muscle","cells","without","cell","division","."),4001773). 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assertion_content_comment('tOboGo_CardioblastProliferation',s("The","multiplication","or","reproduction","of","cardioblasts",",","resulting","in","the","expansion","of","the","population","in","the","heart","field",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4001022). assertion_content_comment('tOboGo_CardiogenicPlateMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","cardiogenic","plate","are","generated","and","organized",".","The","cardiogenic","plate","is","the","first","recognizable","structure","derived","from","the","heart","field","."),4003277). 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assertion_content_comment('tOboGo_CardiolipinSynthetase2Activity',s("Catalysis","of","the","reaction",":","2","1",",","2-diacyl-sn-glycero-3-","[","phospho-rac-","(","1-glycerol",")","]","=","cardiolipin","+","glycerol","."),4327651). assertion_content_comment('tOboGo_CardiovascularSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","cardiovascular","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","cardiovascular","system","is","the","anatomical","system","that","has","as","its","parts","the","heart","and","blood","vessels","."),3980668). assertion_content_comment('tOboGo_CargoLoadingIntoVesicle',s("The","formation","of","a","protein","complex","between","the","coat","proteins","and","proteins","that","are","going","to","be","transported","by","a","vesicle","."),4084629). assertion_content_comment('tOboGo_CarnitinamidaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-carnitinamide","+","H","(","2",")","O","=","(","R",")","-carnitine","+","NH","(","4",")","(","+",")"),4374065). assertion_content_comment('tOboGo_Carnitine_AcylCarnitineAntiporterActivity',s("Catalysis","of","the","reaction",":","carnitine","(","mitochondrial",")","+","acyl","carnitine","(","cytoplasm",")","=","carnitine","(","cytoplasm",")","+","acyl","carnitine","(","mitochondrial",")"),4219240). assertion_content_comment('tOboGo_CarnitineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","carnitine","(","hydroxy-trimethyl","aminobutyric","acid",")",",","a","compound","that","participates","in","the","transfer","of","acyl","groups","across","the","inner","mitochondrial","membrane","."),4298661). assertion_content_comment('tOboGo_CarnitineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carnitine","(","hydroxy-trimethyl","aminobutyric","acid",")",",","a","compound","that","participates","in","the","transfer","of","acyl","groups","across","the","inner","mitochondrial","membrane","."),4312415). assertion_content_comment('tOboGo_CarnitineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","carnitine","+","H","(","+",")","=","2-methylcholine","+","CO","(","2",")"),4373577). assertion_content_comment('tOboGo_CarnitineDehydrataseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-carnitine","=","crotono-betaine","+","H","(","2",")","O","."),4252400). 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assertion_content_comment('tOboGo_CarnitineTransporterActivity',s("Enables","the","directed","movement","of","carnitine","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Carnitine","is","a","compound","that","participates","in","the","transfer","of","acyl","groups","across","the","inner","mitochondrial","membrane","."),4295583). assertion_content_comment('tOboGo_CarnitineTransport',s("The","directed","movement","of","carnitine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Carnitine","is","a","compound","that","participates","in","the","transfer","of","acyl","groups","across","the","inner","mitochondrial","membrane","."),4228708). assertion_content_comment('tOboGo_CarnosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","dipeptide","beta-alanyl-L-histidine","(","carnosine",")"),4376902). assertion_content_comment('tOboGo_CarnosineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","dipeptide","beta-alanyl-L-histidine","(","carnosine",")"),4376891). assertion_content_comment('tOboGo_CarnosineSynthaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","L-histidine","+","beta-alanine","=","AMP","+","diphosphate","+","carnosine","."),4373553). assertion_content_comment('tOboGo_CaroteneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","carotenes",",","hydrocarbon","carotenoids","."),4302869). assertion_content_comment('tOboGo_CaroteneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carotenes",",","hydrocarbon","carotenoids","."),4302926). assertion_content_comment('tOboGo_CaroteneEpsilonHydroxylaseActivity',s("Catalysis","of","the","reaction",":","a","carotene","+","NADPH","+","O2","+","H","+","=","a","beta-ring","hydroxylcarotene","+","NADP","+","+","H2O",".","Adds","a","hydroxyl","group","to","the","epsilon","ring","of","the","alpha-carotene","."),4159102). assertion_content_comment('tOboGo_CaroteneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carotenes",",","hydrocarbon","carotenoids","."),4302865). assertion_content_comment('tOboGo_CarotenoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","carotenoids",",","tetraterpenoid","compounds","in","which","two","units","of","4","isoprenoid","residues","joined","head-to-tail","are","themselves","joined","tail-to-tail","."),4302849). assertion_content_comment('tOboGo_CarotenoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","carotenoids",",","tetraterpenoid","compounds","in","which","two","units","of","4","isoprenoid","residues","joined","head-to-tail","are","themselves","joined","tail-to-tail","."),4302919). assertion_content_comment('tOboGo_CarotenoidDioxygenaseActivity',s("Catalysis","of","the","oxidative","cleavage","of","carotenoids","."),4299366). assertion_content_comment('tOboGo_CarotenoidIsomeraseActivity',s("Catalysis","of","the","isomerization","of","poly-cis-carotenoids","to","all-trans-carotenoids","."),4359958). assertion_content_comment('tOboGo_CarotenoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","carotenoids",",","tetraterpenoid","compounds","in","which","two","units","of","4","isoprenoid","residues","joined","head-to-tail","are","themselves","joined","tail-to-tail","."),4302845). assertion_content_comment('tOboGo_CarotenoidTransport',s("The","directed","movement","of","carotenoids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Carotenoids","are","tetraterpenoid","compounds","in","which","two","units","of","4","isoprenoid","residues","joined","head-to-tail","are","themselves","joined","tail-to-tail","."),4358437). assertion_content_comment('tOboGo_CarotenoidVesicle',s("A","tissue-specific","cytoplasmic","vesicle","surrounded","by","a","membrane","half-leaflet","within","which","carotenoid","pigments","are","stored",".","Carotenoid","vescicles","are","synthesized","in","xanthophores","and","erythrophore","cells","and","are","yellow",",","orange","or","red","in","appearance","."),4326219). assertion_content_comment('tOboGo_CarotidBodyGlomusCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","structural","and/or","functional","features","of","a","glomus","cell","of","the","carotid","body",".","The","carotid","body","is","a","specialized","chemosensory","organ","that","helps","respond","to","hypoxia","."),4135311). assertion_content_comment('tOboGo_CarpelDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","carpel","over","time",",","from","its","formation","to","the","mature","structure",".","A","carpel","is","an","organ","(","generally","believed","to","be","a","modified","foliar","unit",")","at","the","centre","of","a","flower",",","bearing","one","or","more","ovules","and","having","its","margins","fused","together","or","with","other","carpels","to","enclose","the","ovule","in","an","ovary",",","and","consisting","also","of","a","stigma","and","usually","a","style","."),4028891). assertion_content_comment('tOboGo_CarpelFormation',s("The","process","that","gives","rise","to","the","carpel",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4032312). assertion_content_comment('tOboGo_CarpelMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","carpel","are","generated","and","organized","."),4028893). assertion_content_comment('tOboGo_CarpelStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","carpel",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4103214). assertion_content_comment('tOboGo_CartilageMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","cartilage","are","generated","and","organized","."),4004278). assertion_content_comment('tOboGo_CarveolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","1S",",","5R",")","-carveol","+","NADP","(","+",")","=","(","R",")","-carvone","+","H","(","+",")","+","NADPH","."),4281765). assertion_content_comment('tOboGo_CarvoneReductaseActivity',s("Catalysis","of","the","reaction",":","carvone","+","2","H","+","+","2","e-","=","dihydrocarvone","."),4277277). assertion_content_comment('tOboGo_CasbeneSynthaseActivity',s("Catalysis","of","the","reaction",":","all-trans-geranylgeranyl","diphosphate","=","casbene","+","diphosphate","."),4267145). assertion_content_comment('tOboGo_CaseinKinaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4202751). assertion_content_comment('tOboGo_CaseinKinaseIActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4202682). assertion_content_comment('tOboGo_CasparianStrip',s("Region","of","plant","cell","wall","specialised","to","act","as","a","seal","to","prevent","back","leakage","of","secreted","material","(","analogous","to","tight","junction","between","epithelial","cells",")","Found","particularly","where","root","parenchymal","cells","secrete","solutes","into","xylem","vessels",".","The","barrier","is","composed","of","suberin",";","a","fatty","substance",",","containing","long","chain","fatty","acids","and","fatty","esters",",","also","found","in","the","cell","walls","of","cork","cells","(","phellem",")","in","higher","plants","."),4104001). assertion_content_comment('tOboGo_CaspaseActivatorActivity',s("Increases","the","rate","of","proteolysis","catalyzed","by","a","caspase","."),4253254). assertion_content_comment('tOboGo_CaspaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","a","peptide","bond","on","the","carboxyl","side","of","an","aspartate","residue","."),4308240). assertion_content_comment('tOboGo_CaspaseComplex',s("A","protein","complex","that","is","located","in","the","cytosol","and","acts","as","a","cysteine-type","endopeptidase","are","involved","in","apoptosis",";","the","peptidase","activity","has","specificity","for","the","hydrolysis","of","aspartyl","bonds","."),4255359). assertion_content_comment('tOboGo_CaspaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","caspase",",","any","of","a","group","of","cysteine","proteases","involved","in","apoptosis","."),4318080). assertion_content_comment('tOboGo_CaspaseRegulatorActivity',s("Modulates","the","activity","of","a","caspase",",","any","of","a","group","of","cysteine","proteases","involved","in","apoptosis","."),4253252). assertion_content_comment('tOboGo_CasteDeterminationInfluenceByEnvironmentalFactors',s("The","process","in","which","individuals",",","having","the","potential","to","develop","any","of","several","distinct","developmental","paths",",","have","their","individual","developmental","fate","determined","in","response","to","environmental","cues",".","Individuals","with","distinct","developmental","fates","perform","different","functions","in","a","colony","of","social","insects","."),4332681). assertion_content_comment('tOboGo_CasteDeterminationInfluenceByGeneticFactors',s("The","process","in","which","individuals",",","having","the","potential","to","develop","any","of","several","distinct","developmental","paths",",","have","their","individual","developmental","fate","determined","in","response","to","genetic","cues",".","Individuals","with","distinct","developmental","fates","perform","different","functions","in","a","colony","of","social","insects","."),4332661). 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assertion_content_comment('tOboGo_CatabolismByHostOfSubstanceInSymbiont',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","its","symbiont","resulting","in","the","breakdown","of","substances",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110055). assertion_content_comment('tOboGo_CatabolismByHostOfSymbiontCarbohydrate',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","carbohydrate","molecules","within","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110081). assertion_content_comment('tOboGo_CatabolismByHostOfSymbiontCellWallCellulose',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","cellulose","in","the","symbiont","cell","wall",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110095). assertion_content_comment('tOboGo_CatabolismByHostOfSymbiontCellWallChitin',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","chitin","in","the","symbiont","cell","wall",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110207). assertion_content_comment('tOboGo_CatabolismByHostOfSymbiontCellWallPectin',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","pectin","in","the","symbiont","cell","wall",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4110159). assertion_content_comment('tOboGo_CatabolismByHostOfSymbiontGlucan',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","glucan","molecules","within","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190396). 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assertion_content_comment('tOboGo_CatabolismByOrganismOfCellWallCelluloseInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","cellulose","in","the","cell","wall","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4110017). assertion_content_comment('tOboGo_CatabolismByOrganismOfCellWallChitinInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","chitin","in","the","cell","wall","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4110191). 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assertion_content_comment('tOboGo_CatabolismByOrganismOfGlucanInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","glucan","molecules","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190384). assertion_content_comment('tOboGo_CatabolismByOrganismOfMacromoleculeInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","macromolecules","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109949). assertion_content_comment('tOboGo_CatabolismByOrganismOfProteinInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","protein","macromolecules","within","the","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190427). assertion_content_comment('tOboGo_CatabolismByOrganismOfXylanInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","xylan","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190476). 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assertion_content_comment('tOboGo_CatabolismBySymbiontOfHostCellWallChitin',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","chitin","in","the","host","cell","wall",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121066). assertion_content_comment('tOboGo_CatabolismBySymbiontOfHostCellWallPectin',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","pectin","in","the","host","cell","wall",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121114). assertion_content_comment('tOboGo_CatabolismBySymbiontOfHostGlucan',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","glucan","molecules","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194867). assertion_content_comment('tOboGo_CatabolismBySymbiontOfHostMacromolecule',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","macromolecules","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121035). assertion_content_comment('tOboGo_CatabolismBySymbiontOfHostProtein',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","protein","macromolecules","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194823). assertion_content_comment('tOboGo_CatabolismBySymbiontOfHostXylan',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","xylan","within","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194845). assertion_content_comment('tOboGo_CatabolismBySymbiontOfSubstanceInHost',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","its","host","resulting","in","the","breakdown","of","substances",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4121020). assertion_content_comment('tOboGo_CatabolismOfSubstanceInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","in","a","second","organism","resulting","in","the","breakdown","of","substances",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109934). assertion_content_comment('tOboGo_Catagen',s("The","regression","phase","of","the","hair","cycle","during","which","cell","proliferation","ceases",",","the","hair","follicle","shortens",",","and","an","anchored","club","hair","is","produced","."),4077877). assertion_content_comment('tOboGo_CatalaseActivity',s("Catalysis","of","the","reaction",":","2","hydrogen","peroxide","=","O2","+","2","H2O","."),4212117). assertion_content_comment('tOboGo_CatalaseReaction',s("OBSOLETE",".","The","processes","involved","in","the","induction","or","activation","of","catalase",",","an","enzyme","that","catalyzes","the","conversion","of","H2O2","into","H2O","."),4228842). assertion_content_comment('tOboGo_CatalysisOfFreeRadicalFormation',s("Catalysis","of","a","reaction","that","generates","a","free","radical",",","a","highly","reactive","molecule","with","an","unsatisfied","electron","valence","pair","."),4318305). assertion_content_comment('tOboGo_CatalyticActivity',s("Catalysis","of","a","biochemical","reaction","at","physiological","temperatures",".","In","biologically","catalyzed","reactions",",","the","reactants","are","known","as","substrates",",","and","the","catalysts","are","naturally","occurring","macromolecular","substances","known","as","enzymes",".","Enzymes","possess","specific","binding","sites","for","substrates",",","and","are","usually","composed","wholly","or","largely","of","protein",",","but","RNA","that","has","catalytic","activity","(","ribozyme",")","is","often","also","regarded","as","enzymatic","."),3974927). assertion_content_comment('tOboGo_CatalyticStep1Spliceosome',s("A","spliceosomal","complex","that","is","formed","by","the","displacement","of","the","two","snRNPs","from","the","precatalytic","spliceosome",";","three","snRNPs","including","U5","remain","associated","with","the","mRNA",".","This","complex",",","sometimes","called","the","activated","spliceosome",",","is","the","catalytically","active","form","of","the","spliceosome",",","and","includes","many","proteins","in","addition","to","those","found","in","the","associated","snRNPs","."),4167695). assertion_content_comment('tOboGo_CatalyticStep2Spliceosome',s("A","spliceosomal","complex","that","contains","three","snRNPs",",","including","U5",",","bound","to","a","splicing","intermediate","in","which","the","first","catalytic","cleavage","of","the","5","'","splice","site","has","occurred",".","The","precise","subunit","composition","differs","significantly","from","that","of","the","catalytic","step","1",",","or","activated",",","spliceosome",",","and","includes","many","proteins","in","addition","to","those","found","in","the","associated","snRNPs","."),4167724). assertion_content_comment('tOboGo_CatecholamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","of","a","group","of","physiologically","important","biogenic","amines","that","possess","a","catechol","(","3",",","4-dihydroxyphenyl",")","nucleus","and","are","derivatives","of","3",",","4-dihydroxyphenylethylamine","."),4231988). assertion_content_comment('tOboGo_CatecholamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","of","a","group","of","physiologically","important","biogenic","amines","that","possess","a","catechol","(","3",",","4-dihydroxyphenyl",")","nucleus","and","are","derivatives","of","3",",","4-dihydroxyphenylethylamine","."),3992094). assertion_content_comment('tOboGo_CatecholamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","of","a","group","of","physiologically","important","biogenic","amines","that","possess","a","catechol","(","3",",","4-dihydroxyphenyl",")","nucleus","and","are","derivatives","of","3",",","4-dihydroxyphenylethylamine","."),3992022). assertion_content_comment('tOboGo_CatecholamineSecretion',s("The","regulated","release","of","catecholamines","by","a","cell","or","group","of","cells",".","The","catecholamines","are","a","group","of","physiologically","important","biogenic","amines","that","possess","a","catechol","(","3",",","4-dihydroxyphenyl",")","nucleus","and","are","derivatives","of","3",",","4-dihydroxyphenylethylamine","."),4026646). assertion_content_comment('tOboGo_CatecholamineTransport',s("The","directed","movement","of","catecholamines",",","a","group","of","physiologically","important","biogenic","amines","that","possess","a","catechol","(","3",",","4-dihydroxyphenyl",")","nucleus","and","are","derivatives","of","3",",","4-dihydroxyphenylethylamine","."),4026631). assertion_content_comment('tOboGo_CatecholamineUptakeInvolvedInSynapticTransmission',s("The","uptake","of","catecholamine","neurotransmitters","by","neurons","or","glial","cells",".","This","process","leads","to","inactivation","and","recycling","of","neurotransmitters","."),4120357). assertion_content_comment('tOboGo_CatecholBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","catechol",",","a","compound","containing","a","pyrocatechol","nucleus","or","substituent","."),4231981). assertion_content_comment('tOboGo_CatecholCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","catechol",",","a","compound","containing","a","pyrocatechol","nucleus","or","substituent","."),3992088). assertion_content_comment('tOboGo_CatecholDioxygenaseActivity',s("Catalysis","of","the","reaction",":","catechol","+","O2","=","a","muconate","."),4237131). assertion_content_comment('tOboGo_CatecholMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","compound","containing","a","pyrocatechol","(","1",",","2-benzenediol",")","nucleus","or","substituent","."),3992019). assertion_content_comment('tOboGo_CatecholOxidaseActivity',s("Catalysis","of","the","reaction",":","2","catechol","+","O2","=","2","1",",","2-benzoquinone","+","2","H2O","."),4212160). assertion_content_comment('tOboGo_CatecholOxidaseDimerizingActivity',s("Catalysis","of","the","reaction",":","4","catechol","+","3","O2","=","2","dibenzo","[","1",",","4","]","dioxin-2",",","3-dione","+","6","H2O","."),4373567). assertion_content_comment('tOboGo_CateninComplex',s("Complex","of","peripheral","cytoplasmic","proteins","(","alpha-",",","beta-","and","gamma-catenin",")","that","interact","with","the","cytoplasmic","region","of","uvomorulin/E-cadherin","to","connect","it","to","the","actin","cytoskeleton","."),4304446). assertion_content_comment('tOboGo_CateninImportIntoNucleus',s("The","directed","movement","of","a","catenin","protein","from","the","cytoplasm","into","the","nucleus","."),4083117). assertion_content_comment('tOboGo_CathepsinBActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds","with","a","broad","specificity",".","Preferentially","cleaves","the","terminal","bond","of","-Arg-Arg-Xaa","motifs","in","small","molecule","substrates","(","thus","differing","from","cathepsin","L",")","In","addition","to","being","an","endopeptidase",",","shows","peptidyl-dipeptidase","activity",",","liberating","C-terminal","dipeptides","."),4209319). assertion_content_comment('tOboGo_CathepsinDActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",".","Specificity","similar","to",",","but","narrower","than",",","that","of","pepsin","A",".","Does","not","cleave","the","Gln4-His5","bond","in","the","B","chain","of","insulin","."),4210445). assertion_content_comment('tOboGo_CathepsinEActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",".","Similar","to","cathepsin","D",",","but","slightly","broader","specificity","."),4210405). assertion_content_comment('tOboGo_CathepsinFActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",".","Cleavage","of","substrates","with","Phe","and","Leu","in","P2","."),4301930). assertion_content_comment('tOboGo_CathepsinGActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",".","Specificity","similar","to","chymotrypsin","C","."),4209371). assertion_content_comment('tOboGo_CathepsinHActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",",","acting","as","an","aminopeptidase","(","notably",",","cleaving","Arg-Xaa","bonds",")","as","well","as","an","endopeptidase","."),4209274). assertion_content_comment('tOboGo_CathepsinKActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",".","Has","a","broad","proteolytic","activity",".","With","small-molecule","substrates","and","inhibitors",",","the","major","determinant","of","specificity","is","P2",",","which","is","preferably","Leu",",","Met","&","gt",";","Phe",",","and","not","Arg","."),4209260). assertion_content_comment('tOboGo_CathepsinLActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",".","Specificity","close","to","that","of","papain",".","As","compared","to","cathepsin","B",",","cathepsin","L","exhibits","higher","activity","towards","protein","substrates",",","but","has","little","activity","on","Z-Arg-Arg-NHMec",",","and","no","peptidyl-dipeptidase","activity","."),4209248). assertion_content_comment('tOboGo_CathepsinSActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds",".","Similar","to","cathepsin","L",",","but","with","much","less","activity","on","the","terminal","bond","of","Z-Phe-Arg-NHMec",",","and","more","activity","on","the","terminal","bond","of","Z-Val-Val-Arg-Xaa","compounds","."),4209237). assertion_content_comment('tOboGo_Cation_AminoAcidSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","amino","acid","(","out",")","+","cation","(","out",")","=","amino","acid","(","in",")","+","cation","(","in",")"),4215643). assertion_content_comment('tOboGo_CationBinding',s("Interacting","selectively","and","non-covalently","with","cations",",","charged","atoms","or","groups","of","atoms","with","a","net","positive","charge","."),4079819). assertion_content_comment('tOboGo_Cation_CationAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","cation","A","(","out",")","+","cation","B","(","in",")","=","cation","A","(","in",")","+","cation","B","(","out",")"),4219493). assertion_content_comment('tOboGo_CationChannelActivity',s("Catalysis","of","the","energy-independent","passage","of","cations","across","a","lipid","bilayer","down","a","concentration","gradient","."),4158425). assertion_content_comment('tOboGo_CationChannelComplex',s("An","ion","channel","complex","through","which","cations","pass","."),3981968). assertion_content_comment('tOboGo_Cation_ChlorideSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","cation","(","out",")","+","Cl-","(","out",")","=","cation","(","in",")","+","Cl-","(","in",")"),4254702). assertion_content_comment('tOboGo_CationEffluxTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","cation","or","cations","from","the","inside","of","the","cell","to","the","outside","of","the","cell","across","a","membrane","."),4296219). assertion_content_comment('tOboGo_CationHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","cations","within","an","organism","or","cell","."),4011637). assertion_content_comment('tOboGo_CationicAminoAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","positively","charged","amino","acid","from","one","side","of","the","membrane","to","the","other","."),4296415). assertion_content_comment('tOboGo_Cation_SugarSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","sugar","(","out",")","+","cation","(","out",")","=","sugar","(","in",")","+","cation","(","in",")"),4216428). assertion_content_comment('tOboGo_CationTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","cation","from","one","side","of","the","membrane","to","the","other","."),4156869). assertion_content_comment('tOboGo_CationTransport',s("The","directed","movement","of","cations",",","atoms","or","small","molecules","with","a","net","positive","charge",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3991114). assertion_content_comment('tOboGo_CaudalFinDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","caudal","fin","over","time",",","from","its","formation","to","the","mature","structure","."),4071905). assertion_content_comment('tOboGo_CaudalFinMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","caudal","fin","are","generated","and","organized",".","A","caudal","fin","is","an","unpaired","medial","fin","mounted","at","the","caudal","end","of","the","fish",",","and","is","the","main","fin","used","for","propulsion","."),4071915). assertion_content_comment('tOboGo_CaudalGanglionicEminenceCellProliferation',s("The","multiplication","or","reproduction","of","caudal","ganglionic","eminence","cells",",","resulting","in","the","expansion","of","a","cell","population","."),4336740). assertion_content_comment('tOboGo_CaudateNucleusDevelopment',s("The","progression","of","the","caudate","nucleus","over","time","from","its","initial","formation","until","its","mature","state",".","The","caudate","nucleus","is","the","C-shaped","structures","of","the","striatum","containing","input","neurons","involved","with","control","of","voluntary","movement","in","the","brain","."),4049549). assertion_content_comment('tOboGo_CaveolaAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","caveola",".","A","caveola","is","a","plasma","membrane","raft","that","forms","a","small","pit",",","depression",",","or","invagination","that","communicates","with","the","outside","of","a","cell","and","extends","inward",",","indenting","the","cytoplasm","and","the","cell","membrane","."),4178889). assertion_content_comment('tOboGo_CaveolarMacromolecularSignalingComplex',s("A","complex","composed","of","proteins","required","for","beta","adrenergic","receptor","activation","of","protein","kinase","A",".","It","includes","the","Cav","12",".","subunit","of","L-type","calcium","channel",",","protein","kinase","A","regulatory","subunit","2","(","PKAR2",")",",","adenyl","cyclase",",","beta-adrenergic","receptor",",","G-alpha-S",",","protein","phosphatase","2A","(","PP2A",")","and","caveolin","3","(","CAV3",")"),3992849). assertion_content_comment('tOboGo_Caveola',s("A","membrane","raft","that","forms","small","pit",",","depression",",","or","invagination","that","communicates","with","the","outside","of","a","cell","and","extends","inward",",","indenting","the","cytoplasm","and","the","cell","membrane",".","Examples","include","any","of","the","minute","pits","or","incuppings","of","the","cell","membrane","formed","during","pinocytosis",".","Such","caveolae","may","be","pinched","off","to","form","free","vesicles","within","the","cytoplasm","."),3992836). assertion_content_comment('tOboGo_CBF3Complex',s("A","multisubunit","protein","complex","that","binds","to","centromeric","DNA","and","initiates","kinetochore","assembly",".","In","yeast",",","this","complex","consists","of","four","subunits",",","namely","Ctf13p",",","Skp1p",",","Cep3p","and","Cbf2p","."),4060734). assertion_content_comment('tOboGo_CBMComplex',s("A","protein","complex","comprising","Carma1",",","Bcl10","and","MALT1",";","plays","a","role","in","signal","transduction","during","NF-kappaB","activation","."),4334719). assertion_content_comment('tOboGo_CCR10ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR10","chemokine","receptor","."),4323439). assertion_content_comment('tOboGo_CCR11ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR11","chemokine","receptor","."),4323449). assertion_content_comment('tOboGo_CCR1ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR1","chemokine","receptor","."),4323322). assertion_content_comment('tOboGo_CCR2ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR2","chemokine","receptor","."),4323333). assertion_content_comment('tOboGo_CCR3ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR3","chemokine","receptor","."),4323240). assertion_content_comment('tOboGo_CCR4ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR4","chemokine","receptor","."),4323251). assertion_content_comment('tOboGo_CCR5ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR5","chemokine","receptor","."),4323230). assertion_content_comment('tOboGo_CCR6ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR6","chemokine","receptor","."),4323394). assertion_content_comment('tOboGo_CCR7ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR7","chemokine","receptor","."),4323405). assertion_content_comment('tOboGo_CCR8ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR8","chemokine","receptor","."),4323374). assertion_content_comment('tOboGo_CCR9ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR9","chemokine","receptor","."),4323384). assertion_content_comment('tOboGo_CCRChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CCR","chemokine","receptor","."),4323225). assertion_content_comment('tOboGo_CD154ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","CD154",",","a","receptor","found","on","the","surface","of","some","activated","lymphocytes","."),4213937). assertion_content_comment('tOboGo_CD24BiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","CD24",",","a","CD","marker","and","cell","adhesion","molecule","that","occurs","on","many","B-lineage","cells","and","mature","granulocytes",",","and","is","involved","in","B","cell","activation","and","differentiation","as","well","as","T","cell","co-stimulation","."),4144318). assertion_content_comment('tOboGo_CD27ReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4213920). assertion_content_comment('tOboGo_CD27ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CD27",",","a","receptor","found","on","the","surface","of","T","cells","and","some","B","cells","and","NK","cells","."),4217046). assertion_content_comment('tOboGo_CD40ReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4213942). assertion_content_comment('tOboGo_CD40ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","CD40",",","a","receptor","found","on","the","surface","of","all","B-lymphocytes","."),4217055). assertion_content_comment('tOboGo_CD40ReceptorComplex',s("A","protein","complex","that","contains","at","least","CD40","(","a","cell","surface","receptor","of","the","tumour","necrosis","factor","receptor","(","TNFR",")","superfamily",")",",","and","other","signaling","molecules","."),4081958). assertion_content_comment('tOboGo_CD40SignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","the","receptor","CD40","."),4143379). 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assertion_content_comment('tOboGo_CellGrowthInvolvedInGrowthPlateCartilageChondrocyteMorphogensis',s("The","growth","of","a","growth","plate","cartilage","chondrocyte",",","where","growth","contributes","to","the","shaping","of","the","chondrocyte","over","time","."),4004261). assertion_content_comment('tOboGo_CellGrowthInvolvedInMalpighianTubuleMorphogenesis',s("The","growth","of","an","epithelial","cell","dependent","on","cycles","of","endoreplication",",","where","growth","contributes","to","the","shaping","of","the","Malpighian","tubule","."),4134961). assertion_content_comment('tOboGo_CellGrowthModeSwitchBipolarToMonopolar',s("The","process","in","which","a","cell","switches","from","bipolar","cell","growth","to","monopolar","cell","growth","."),4283566). assertion_content_comment('tOboGo_CellGrowthModeSwitchingMonopolarToBipolar',s("The","process","in","which","a","cell","switches","from","monopolar","cell","growth","to","bipolar","cell","growth","."),4283517). 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assertion_content_comment('tOboGo_CellMigrationInDiencephalon',s("The","orderly","movement","of","a","cell","that","will","reside","in","the","diencephalon","."),4133481). assertion_content_comment('tOboGo_CellMigrationInHindbrain',s("The","orderly","movement","of","a","cell","that","will","reside","in","the","hindbrain","."),4041297). assertion_content_comment('tOboGo_CellMigrationInvolvedInCoronaryAngiogenesis',s("The","orderly","movement","of","a","cell","from","one","site","to","another","that","will","contribute","to","the","formation","of","new","blood","vessels","in","the","heart","from","pre-existing","blood","vessels","."),4113044). assertion_content_comment('tOboGo_CellMigrationInvolvedInCoronaryVasculogenesis',s("The","orderly","movement","of","a","cell","from","one","site","to","another","that","will","contribute","to","the","differentiation","of","an","endothelial","cell","that","will","form","the","blood","vessels","of","the","heart","."),4113067). 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assertion_content_comment('tOboGo_CellMigrationInvolvedInHeartDevelopment',s("The","orderly","movement","of","a","cell","from","one","site","to","another","that","will","contribute","to","the","progression","of","the","heart","over","time",",","from","its","initial","formation",",","to","the","mature","organ","."),4001481). assertion_content_comment('tOboGo_CellMigrationInvolvedInHeartFormation',s("The","orderly","movement","of","a","cell","from","one","site","to","another","that","contribute","to","the","formation","of","the","heart",".","The","initial","heart","structure","is","made","up","of","mesoderm-derived","heart","progenitor","cells","and","neural","crest-derived","cells","."),4003191). assertion_content_comment('tOboGo_CellMigrationInvolvedInHeartJogging',s("The","orderly","movement","of","a","cell","of","the","myocardium","from","one","site","to","another","that","will","contribute","to","heart","jogging","."),4001916). assertion_content_comment('tOboGo_CellMigrationInvolvedInKidneyDevelopment',s("The","orderly","movement","of","a","cell","from","one","site","to","another","that","will","contribute","to","the","progression","of","the","kidney","over","time",",","from","its","formation","to","the","mature","organ","."),4081513). assertion_content_comment('tOboGo_CellMigrationInvolvedInMammaryPlacodeFormation',s("The","orderly","movement","of","epithelial","cells","within","the","mammary","line","that","contributes","to","the","formation","of","the","mammary","placode","."),4111852). assertion_content_comment('tOboGo_CellMigrationInvolvedInMesendodermMigration',s("The","orderly","movement","of","epithelial","cells","from","one","site","to","another","that","contributes","to","the","migration","of","mesendodermal","tissue","."),4005634). assertion_content_comment('tOboGo_CellMigrationInvolvedInMetanephrosDevelopment',s("The","orderly","movement","of","a","cell","from","one","site","to","another","that","will","contribute","to","the","progression","of","the","metanephric","kidney","over","time",",","from","its","formation","to","the","mature","organ","."),4081523). assertion_content_comment('tOboGo_CellMigrationInvolvedInProstaticBudElongation',s("The","orderly","movement","of","epithelial","cells","from","one","site","to","another","contributing","to","the","elongation","of","the","primary","prostatic","bud","."),4116764). assertion_content_comment('tOboGo_CellMigrationInvolvedInSomitogenicAxisElongation',s("The","orderly","movement","of","a","presomitic","mesoderm","cell","that","contributes","to","somitogenic","axis","elongation","."),4155633). assertion_content_comment('tOboGo_CellMigrationInvolvedInSproutingAngiogenesis',s("The","orderly","movement","of","endothelial","cells","into","the","extracellular","matrix","in","order","to","form","new","blood","vessels","involved","in","sprouting","angiogenesis","."),3990788). assertion_content_comment('tOboGo_CellMigrationInvolvedInVasculogenesis',s("The","orderly","movement","of","a","cell","from","one","site","to","another","that","will","contribute","to","the","differentiation","of","an","endothelial","cell","that","will","form","de","novo","blood","vessels","and","tubes","."),4082925). assertion_content_comment('tOboGo_CellMigration',s("The","orderly","movement","of","a","cell","from","one","site","to","another",",","often","during","the","development","of","a","multicellular","organism","or","multicellular","structure","."),3985083). assertion_content_comment('tOboGo_CellMigrationToTheMidlineInvolvedInHeartDevelopment',s("The","orderly","movement","of","a","cell","toward","the","midline","that","contributes","to","the","progression","of","the","heart","over","time","."),4002036). assertion_content_comment('tOboGo_CellMorphogenesisInvolvedInConjugation',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","during","sexual","reproduction","in","order","to","facilitate","direct","contact","between","the","compatible","mating","types","."),3977658). assertion_content_comment('tOboGo_CellMorphogenesisInvolvedInConjugationWithCellularFusion',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","during","sexual","reproduction","in","order","to","facilitate","direct","contact","between","the","compatible","mating","types","in","organisms","that","undergo","conjugation","cellular","fusion","."),3977674). assertion_content_comment('tOboGo_CellMorphogenesisInvolvedInConjugationWithMutualGeneticExchange',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","during","sexual","reproduction","in","order","to","facilitate","direct","contact","between","the","compatible","mating","types","in","organisms","that","undergo","conjugation","without","cellular","fusion","."),3977754). assertion_content_comment('tOboGo_CellMorphogenesisInvolvedInDifferentiation',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","when","relatively","unspecialized","cells",",","e.g",".","embryonic","or","regenerative","cells",",","acquire","specialized","structural","and/or","functional","features","that","characterize","the","cells",",","tissues",",","or","organs","of","the","mature","organism","or","some","other","relatively","stable","phase","of","the","organism","'","s","life","history","."),3978813). assertion_content_comment('tOboGo_CellMorphogenesisInvolvedInMalpighianTubuleMorphogenesis',s("The","shape","change","of","an","epithelial","cell","from","a","columnar","to","squamous","cell","morphology","that","contributes","to","the","shaping","of","the","Malpighian","tubule","."),4135001). assertion_content_comment('tOboGo_CellMorphogenesisInvolvedInNeuronDifferentiation',s("The","process","in","which","the","structures","of","a","neuron","are","generated","and","organized",".","This","process","occurs","while","the","initially","relatively","unspecialized","cell","is","acquiring","the","specialized","features","of","a","neuron","."),3992754). assertion_content_comment('tOboGo_CellMorphogenesisInvolvedInSemicircularCanalFusion',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","when","a","semicircular","canal","epithelial","cell","acquires","the","structural","features","that","allow","it","to","contribute","to","the","process","of","semicircular","canal","fusion","."),4114004). assertion_content_comment('tOboGo_CellMorphogenesisInvolvedInUnidirectionalConjugation',s("OBSOLETE",".","The","change","in","form","(","cell","shape","and","size",")","that","occurs","during","sexual","reproduction","in","order","to","facilitate","direct","contact","between","the","compatible","mating","types","in","organisms","that","undergo","unidirectional","conjugation","."),4363757). assertion_content_comment('tOboGo_CellMorphogenesis',s("The","developmental","process","in","which","the","size","or","shape","of","a","cell","is","generated","and","organized","."),3977654). assertion_content_comment('tOboGo_CellMotilityInvolvedInCerebralCortexRadialGliaGuidedMigration',s("The","movement","of","a","cell","along","the","process","of","a","radial","glial","cell","involved","in","cerebral","cortex","glial-mediated","radial","migration","."),4049725). assertion_content_comment('tOboGo_CellMotilityInvolvedInSomitogenicAxisElongation',s("Any","process","involved","in","the","controlled","self-propelled","movement","of","a","cell","that","contributes","to","somitogenic","axis","elongation","."),4151534). assertion_content_comment('tOboGo_CellMotility',s("Any","process","involved","in","the","controlled","self-propelled","movement","of","a","cell","that","results","in","translocation","of","the","cell","from","one","place","to","another","."),3985078). assertion_content_comment('tOboGo_CellMovementInvolvedInSomalTranslocation',s("The","movement","of","a","cell","body","from","the","ventricular","zone","to","the","pial","surface","with","a","concomitant","shortening","of","the","process","that","extends","to","the","pial","surface","."),4050170). assertion_content_comment('tOboGo_CellobioseDehydrogenaseAcceptorActivity',s("Catalysis","of","the","reaction",":","cellobiose","+","acceptor","=","cellobiono-1",",","5-lactone","+","reduced","acceptor","."),4373533). assertion_content_comment('tOboGo_CellobioseEpimeraseActivity',s("Catalysis","of","the","reaction",":","cellobiose","=","D-glucosyl-D-mannose","."),4373454). assertion_content_comment('tOboGo_CellobioseGlucosidaseActivity',s("Catalysis","of","the","reaction",":","cellobiose","+","H2O","=","2","D-glucose","."),4182434). assertion_content_comment('tOboGo_CellobiosePhosphorylaseActivity',s("Catalysis","of","the","reaction",":","cellobiose","+","phosphate","=","alpha-D-glucose","1-phosphate","+","D-glucose","."),4373444). assertion_content_comment('tOboGo_CellobioseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","cellobiose","from","one","side","of","the","membrane","to","the","other",".","Cellobiose",",","or","4-O-beta-D-glucopyranosyl-D-glucose",",","is","a","disaccharide","that","represents","the","basic","repeating","unit","of","cellulose","."),4237907). assertion_content_comment('tOboGo_CellobioseTransport',s("The","directed","movement","of","cellobiose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Cellobiose",",","or","4-O-beta-D-glucopyranosyl-D-glucose",",","is","a","disaccharide","that","represents","the","basic","repeating","unit","of","cellulose","."),4242092). assertion_content_comment('tOboGo_CellodextrinPhosphorylaseActivity',s("Catalysis","of","the","reaction",":","1",",","4-beta-D-glucosyl","(","n",")","+","phosphate","=","1",",","4-beta-D-glucosyl","(","n-1",")","+","alpha-D-glucose","1-phosphate","."),4272038). assertion_content_comment('tOboGo_CellOuterMembrane',s("A","lipid","bilayer","that","forms","the","outermost","layer","of","the","cell","envelope",";","enriched","in","polysaccharide","and","protein",";","the","outer","leaflet","of","the","membrane","contains","specific","lipopolysaccharide","structures","."),4023827). assertion_content_comment('tOboGo_CellPartMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","cell","part","are","generated","and","organized","."),4017230). assertion_content_comment('tOboGo_CellPart',s("Any","constituent","part","of","a","cell",",","the","basic","structural","and","functional","unit","of","all","organisms","."),3971312). assertion_content_comment('tOboGo_CellPeriphery',s("The","part","of","a","cell","encompassing","the","cell","cortex",",","the","plasma","membrane",",","and","any","external","encapsulating","structures","."),3971430). assertion_content_comment('tOboGo_CellPlateAssembly',s("The","process","of","assembly",",","maturation",",","and","growth","of","the","cell","plate","to","the","cell","periphery","in","cells","that","divide","by","cell","plate","formation",";","often","involves","deposition","of","cell","wall","material","in","and","around","the","phragmoplast","."),3978627). assertion_content_comment('tOboGo_CellPlate',s("The","nascent","cell","membrane","and","cell","wall","structure","that","forms","between","two","daughter","nuclei","near","the","center","of","a","dividing","plant","cell",".","It","develops","at","the","equitorial","region","of","the","phragmoplast",".","It","grows","outwards","to","join","with","the","lateral","walls","and","form","two","daughter","cells","."),4259505). assertion_content_comment('tOboGo_CellPole',s("Either","of","two","different","areas","at","opposite","ends","of","an","axis","of","a","cell","."),4098053). assertion_content_comment('tOboGo_CellProjectionAssembly',s("Formation","of","a","prolongation","or","process","extending","from","a","cell",",","e.g",".","a","flagellum","or","axon","."),4005730). assertion_content_comment('tOboGo_CellProjectionCytoplasm',s("All","of","the","contents","of","a","cell","projection",",","excluding","the","plasma","membrane","surrounding","the","projection","."),4069505). assertion_content_comment('tOboGo_CellProjectionMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","cell","surface","projection","."),4041978). assertion_content_comment('tOboGo_CellProjectionMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","cell","projection","are","generated","and","organized","."),4017233). assertion_content_comment('tOboGo_CellProjectionOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","prolongation","or","process","extending","from","a","cell",",","e.g",".","a","flagellum","or","axon","."),3982356). assertion_content_comment('tOboGo_CellProjectionPart',s("Any","constituent","part","of","a","cell","projection",",","a","prolongation","or","process","extending","from","a","cell",",","e.g",".","a","flagellum","or","axon","."),3980305). assertion_content_comment('tOboGo_CellProjection',s("A","prolongation","or","process","extending","from","a","cell",",","e.g",".","a","flagellum","or","axon","."),3980280). assertion_content_comment('tOboGo_CellProliferationInBoneMarrow',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","cell","population","in","the","bone","marrow","."),4082078). assertion_content_comment('tOboGo_CellProliferationInDorsalSpinalCord',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","the","dorsal","spinal","cord","cell","population","."),4048957). assertion_content_comment('tOboGo_CellProliferationInExternalGranuleLayer',s("The","multiplication","or","reproduction","of","neuroblasts","resulting","in","the","expansion","of","a","cell","population","in","the","external","granule","layer","of","the","hindbrain",".","The","external","granule","layer","is","the","layer","that","originates","from","the","rostral","half","of","the","rhombic","lip","in","the","first","rhombomere","."),4047897). assertion_content_comment('tOboGo_CellProliferationInForebrain',s("The","creation","of","greater","cell","numbers","in","the","forebrain","due","to","cell","division","of","progenitor","cells","."),4047268). assertion_content_comment('tOboGo_CellProliferationInHindbrain',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","cell","population","in","the","hindbrain","."),4041286). assertion_content_comment('tOboGo_CellProliferationInHindbrainVentricularZone',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","cell","population","in","the","hindbrain","region","that","is","adjacent","to","the","ventricular","cavity","."),4048884). assertion_content_comment('tOboGo_CellProliferationInMidbrain',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","cell","population","in","the","midbrain","."),4066442). assertion_content_comment('tOboGo_CellProliferationInvolvedInAtrialVentricularJunctionRemodeling',s("The","multiplication","or","reproduction","of","cells","that","contributes","to","the","reorganization","of","tissue","resulting","in","the","maturation","of","the","atrial","ventricular","junction","."),4001797). assertion_content_comment('tOboGo_CellProliferationInvolvedInCompoundEyeMorphogenesis',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","cell","population","that","contributes","to","compound","eye","morphogenesis","."),4082532). assertion_content_comment('tOboGo_CellProliferationInvolvedInEmbryonicPlacentaDevelopment',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","the","population","in","the","embryonic","placenta","."),4112580). 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assertion_content_comment('tOboGo_CellularBirthScar',s("Crater-like","ring","of","chitinous","scar","tissue","located","on","the","surface","of","the","daughter","cell",",","in","budding","fungi",",","at","the","site","of","separation","from","the","mother","cell",".","It","is","formed","after","the","newly","emerged","daughter","cell","separates",",","thereby","marking","the","site","of","cytokinesis","and","septation","."),4129892). assertion_content_comment('tOboGo_CellularBudMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","cellular","bud","."),4065699). assertion_content_comment('tOboGo_CellularBudNeckContractileRing',s("A","contractile","ring",",","i.e",".","a","cytoskeletal","structure","composed","of","actin","filaments","and","myosin",",","that","forms","beneath","the","plasma","membrane","at","the","mother-bud","neck","in","mitotic","cells","that","divide","by","budding","in","preparation","for","completing","cytokinesis",".","An","example","of","this","structure","is","found","in","Saccharomyces","cerevisiae","."),3971846). assertion_content_comment('tOboGo_CellularBudNeckPolarisome',s("Protein","complex","that","has","a","role","in","determining","cell","polarity",",","found","at","the","neck","of","a","fungal","bud","before","and","during","cytokinesis","."),4060396). assertion_content_comment('tOboGo_CellularBudNeckSeptinCollar',s("A","tubular","structure","with","flared","ends",",","shaped","like","an","hourglass","and","composed","of","highly","ordered","arrays","of","septin","filaments",",","that","forms","at","the","bud","neck","of","a","dividing","cell",".","In","S",".","cerevisiae",",","this","structure","is","located","at","the","bud","neck","throughout","most","of","the","cell","cycle","and","the","septins","are","fixed","within","the","structure",",","not","exchanging","with","soluble","septins",".","This","septin","structure","acts","as","a","scaffold","for","other","proteins","that","function","at","the","bud","neck","."),4329560). assertion_content_comment('tOboGo_CellularBudNeckSeptinRingOrganization',s("Control","of","the","formation",",","spatial","distribution",",","and","breakdown","of","a","septin","ring","located","at","the","bud","neck","."),4055411). 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assertion_content_comment('tOboGo_CellWallThickening',s("A","type","of","cell","wall","modification","in","which","the","cell","wall","is","reinforced","and","made","thicker","."),4147068). assertion_content_comment('tOboGo_CementGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","cement","gland","over","time",",","from","its","formation","to","the","mature","structure",".","The","cement","gland","is","a","simple","mucus-secreting","organ","positioned","at","the","anterior","of","amphibious","embryos",".","The","cement","gland","attaches","the","newly","hatched","embryo","to","a","support","before","the","hatchling","can","swim","well","or","feed","."),4171181). assertion_content_comment('tOboGo_CementumMineralization',s("The","process","in","which","calcium","salts",",","mainly","carbonated","hydroxyapatite",",","are","deposited","into","the","initial","acellular","cementum","."),4172217). assertion_content_comment('tOboGo_CentralBCellAnergy',s("Any","process","contributing","to","anergy",",","a","state","of","functional","inactivation","that","occurs","as","part","of","tolerance","induction",",","in","B","cells","in","the","bone","marrow","."),3994055). assertion_content_comment('tOboGo_CentralBCellDeletion',s("The","deletion","of","B","cells","by","apoptosis","occurring","as","part","of","central","tolerance","induction","and","B","cell","selection","."),3994069). assertion_content_comment('tOboGo_CentralBCellNegativeSelection',s("Any","process","leading","to","negative","selection","of","B","cells","in","the","bone","marrow","."),4379484). assertion_content_comment('tOboGo_CentralBCellPositiveSelection',s("Any","process","leading","to","positive","selection","of","B","cells","in","the","bone","marrow",".","Positive","selection","is","the","process","in","which","B","or","T","cells","are","selected","to","survive","based","on","signaling","through","their","antigen","receptors","."),4379564). assertion_content_comment('tOboGo_CentralBCellReceptorEditing',s("Receptor","editing","occurring","in","B","cells","in","the","bone","marrow","."),4381593). assertion_content_comment('tOboGo_CentralBCellSelection',s("Any","B","cell","selection","process","that","occurs","in","the","bone","marrow","."),3994018). assertion_content_comment('tOboGo_CentralBCellToleranceInduction',s("Tolerance","induction","of","B","cells","in","the","bone","marrow","."),3994050). assertion_content_comment('tOboGo_CentralComplexDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","central","complex","over","time",",","from","its","formation","to","the","mature","structure",".","The","central","complex","region","of","the","insect","brain","is","thought","to","be","crucial","for","control","of","locomotive","behavior",".","Located","in","the","middle","of","the","two","protocerebral","hemispheres",",","it","comprises","four","neuropilar","regions",",","the","fan-shaped","body",",","the","ellipsoid","body",",","the","protocerebral","bridge","and","the","paired","noduli","."),4104589). assertion_content_comment('tOboGo_CentralElement',s("A","structural","unit","of","the","synaptonemal","complex","found","between","the","lateral","elements","."),3978388). assertion_content_comment('tOboGo_CentralNervousSystemControlOfBaroreceptorFeedback',s("The","neurological","process","in","which","nerve","impulses","arising","in","the","aorta","or","the","carotid","sinuses","travel","to","the","medulla","and","reach","the","nucleus","of","tractus","solaris","."),3999025). assertion_content_comment('tOboGo_CentralNervousSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","central","nervous","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","central","nervous","system","is","the","core","nervous","system","that","serves","an","integrating","and","coordinating","function",".","In","vertebrates","it","consists","of","the","brain",",","spinal","cord","and","spinal","nerves",".","In","those","invertebrates","with","a","central","nervous","system","it","typically","consists","of","a","brain",",","cerebral","ganglia","and","a","nerve","cord","."),4017327). assertion_content_comment('tOboGo_CentralNervousSystemFormation',s("The","process","that","gives","rise","to","the","central","nervous","system",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","central","nervous","system","is","the","core","nervous","system","that","serves","an","integrating","and","coordinating","function",".","In","vertebrates","it","consists","of","the","brain",",","spinal","cord","and","spinal","nerves",".","In","those","invertebrates","with","a","central","nervous","system","it","typically","consists","of","a","brain",",","cerebral","ganglia","and","a","nerve","cord","."),4044943). assertion_content_comment('tOboGo_CentralNervousSystemInterneuronAxonogenesis',s("Generation","of","a","long","process","that","carries","efferent","(","outgoing",")","action","potentials","from","the","cell","body","towards","target","cells","from","a","neuron","located","in","the","central","nervous","system","whose","axons","remain","within","a","single","brain","region","."),4047796). assertion_content_comment('tOboGo_CentralNervousSystemMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","central","nervous","system","to","attain","its","fully","functional","state",".","The","central","nervous","system","is","the","core","nervous","system","that","serves","an","integrating","and","coordinating","function",".","In","vertebrates","it","consists","of","the","brain",",","spinal","cord","and","spinal","nerves",".","In","those","invertebrates","with","a","central","nervous","system","it","typically","consists","of","a","brain",",","cerebral","ganglia","and","a","nerve","cord","."),4042679). assertion_content_comment('tOboGo_CentralNervousSystemMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","central","nervous","system","is","generated","and","organized",".","The","central","nervous","system","is","the","core","nervous","system","that","serves","an","integrating","and","coordinating","function",".","In","vertebrates","it","consists","of","the","brain",",","spinal","cord","and","spinal","nerves",".","In","those","invertebrates","with","a","central","nervous","system","it","typically","consists","of","a","brain",",","cerebral","ganglia","and","a","nerve","cord","."),4044635). assertion_content_comment('tOboGo_CentralNervousSystemMyelination',s("The","process","in","which","neuronal","axons","and","dendrites","become","coated","with","a","segmented","lipid-rich","sheath","(","myelin",")","to","enable","faster","and","more","energetically","efficient","conduction","of","electrical","impulses",".","The","sheath","is","formed","by","the","cell","membranes","of","oligodendrocytes","in","the","central","nervous","system",".","Adjacent","myelin","segments","are","separated","by","a","non-myelinated","stretch","of","axon","called","a","node","of","Ranvier","."),4053264). assertion_content_comment('tOboGo_CentralNervousSystemMyelinFormation',s("The","process","in","which","the","wraps","of","cell","membrane","that","constitute","myelin","are","laid","down","around","an","axon","by","an","oligodendrocyte","in","the","central","nervous","system","."),4054587). assertion_content_comment('tOboGo_CentralNervousSystemMyelinMaintenance',s("The","process","in","which","the","structure","and","material","content","of","mature","central","nervous","system","myelin","is","kept","in","a","functional","state","."),4054509). assertion_content_comment('tOboGo_CentralNervousSystemNeuronAxonogenesis',s("Generation","of","a","long","process","from","a","neuron","whose","cell","body","resides","in","the","central","nervous","system",".","The","process","carries","efferent","(","outgoing",")","action","potentials","from","the","cell","body","towards","target","cells","."),4041103). assertion_content_comment('tOboGo_CentralNervousSystemNeuronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","neuron","whose","cell","body","is","located","in","the","central","nervous","system",",","from","initial","commitment","of","the","cell","to","a","neuronal","fate",",","to","the","fully","functional","differentiated","neuron","."),4041101). assertion_content_comment('tOboGo_CentralNervousSystemNeuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuron","whose","cell","body","resides","in","the","central","nervous","system","."),4041099). assertion_content_comment('tOboGo_CentralNervousSystemProjectionNeuronAxonogenesis',s("Generation","of","a","long","process","of","a","CNS","neuron",",","that","carries","efferent","(","outgoing",")","action","potentials","from","the","cell","body","towards","target","cells","in","a","different","central","nervous","system","region","."),4041105). assertion_content_comment('tOboGo_CentralNervousSystemSegmentation',s("Division","of","the","central","nervous","system","into","a","series","of","semi-repetitive","parts","or","segments","."),4071193). assertion_content_comment('tOboGo_CentralNervousSystemStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","central","nervous","system","structure",".","The","central","nervous","system","is","the","core","nervous","system","that","serves","an","integrating","and","coordinating","function",".","In","vertebrates","it","consists","of","the","brain",",","spinal","cord","and","spinal","nerves",".","In","those","invertebrates","with","a","central","nervous","system","it","typically","consists","of","a","brain",",","cerebral","ganglia","and","a","nerve","cord","."),4044646). assertion_content_comment('tOboGo_CentralNervousSystemVasculogenesis',s("The","differentiation","of","endothelial","cells","from","progenitor","cells","during","blood","vessel","development",",","and","the","de","novo","formation","of","blood","vessels","and","tubes","in","the","central","nervous","system",".","The","capillary","endothelial","cells","in","the","brain","are","specialized","to","form","the","blood-brain","barrier","."),4053276). assertion_content_comment('tOboGo_CentralPlaqueOfSpindlePoleBody',s("One","of","three","laminate","structures","that","form","the","spindle","pole","body",";","the","central","plaque","is","embedded","in","the","nuclear","envelope","."),4007235). assertion_content_comment('tOboGo_CentralTCellToleranceInduction',s("Tolerance","induction","of","T","cells","in","the","thymus","."),4381606). assertion_content_comment('tOboGo_CentralToleranceInduction',s("Tolerance","induction","in","the","central","lymphoid","organs",":","the","thymus","and","bone","marrow","."),3994047). assertion_content_comment('tOboGo_CentralToleranceInductionToNonselfAntigen',s("Tolerance","induction","to","nonself","antigens","in","the","central","lymphoid","organs","."),4381047). assertion_content_comment('tOboGo_CentralToleranceInductionToSelfAntigen',s("Tolerance","induction","in","the","central","lymphoid","organs","directed","at","self","antigens","."),4381584). assertion_content_comment('tOboGo_CentralVacuole',s("A","membrane-enclosed","sac","that","takes","up","most","of","the","volume","of","a","mature","plant","cell",".","Functions","include","storage",",","separation","of","toxic","byproducts",",","and","cell","growth","determination","."),4314707). assertion_content_comment('tOboGo_CentriolarSatellite',s("A","small","(","70-100","nm",")","cytoplasmic","granule","that","contains","a","number","of","centrosomal","proteins",";","centriolar","satellites","traffic","toward","microtubule","minus","ends","and","are","enriched","near","the","centrosome","."),4074995). assertion_content_comment('tOboGo_CentrioleReplication',s("The","cell","cycle","process","in","which","a","daughter","centriole","is","formed","perpendicular","to","an","existing","centriole",".","An","immature","centriole","contains","a","ninefold","radially","symmetric","array","of","single","microtubules",";","mature","centrioles","consist","of","a","radial","array","of","nine","microtubule","triplets",",","doublets",",","or","singlets","depending","upon","the","species","and","cell","type","."),4012534). assertion_content_comment('tOboGo_Centriole',s("A","cellular","organelle",",","found","close","to","the","nucleus","in","many","eukaryotic","cells",",","consisting","of","a","small","cylinder","with","microtubular","walls",",","300-500","nm","long","and","150-250","nm","in","diameter",".","It","contains","nine","short",",","parallel",",","peripheral","microtubular","fibrils",",","each","fibril","consisting","of","one","complete","microtubule","fused","to","two","incomplete","microtubules",".","Cells","usually","have","two","centrioles",",","lying","at","right","angles","to","each","other",".","At","division",",","each","pair","of","centrioles","generates","another","pair","and","the","twin","pairs","form","the","pole","of","the","mitotic","spindle","."),4007184). assertion_content_comment('tOboGo_CentripetallyMigratingFollicleCellMigration',s("The","cell","migration","process","in","which","a","follicle","cell","migrates","as","part","of","an","epithelial","sheet","between","the","nurse","cells","and","the","oocyte",".","At","the","end","of","migration",",","they","cover","the","anterior","of","the","oocyte","."),4159937). assertion_content_comment('tOboGo_CentrolateralAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","centrolateral","axis",".","In","plants",",","this","axis","is","duplicated","and","runs","from","the","midrib","to","the","margin","of","the","leaf","."),4261785). assertion_content_comment('tOboGo_CentromereBinding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235412). assertion_content_comment('tOboGo_CentromereComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","centromeric","DNA","molecules","to","form","a","centromeric","protein-DNA","complex",".","Includes","the","formation","of","the","chromatin","structures","which","form","a","platform","for","the","kinetochore",",","and","assembly","of","the","kinetochore","onto","this","specialized","chromatin",".","In","fission","yeast","and","higher","eukaryotes","this","process","also","includes","the","formation","of","heterochromatin","at","the","outer","repeat","(","pericentric",")","regions","of","the","centromere","."),4060799). assertion_content_comment('tOboGo_CentromereSeparation',s("The","cell","cycle","process","in","which","centromeres","are","physically","detached","from","each","other","during","chromosome","separation","."),4073611). assertion_content_comment('tOboGo_Centromere',s("OBSOLETE",".","The","region","of","a","eukaryotic","chromosome","that","is","attached","to","the","spindle","during","nuclear","division",".","It","is","defined","genetically","as","the","region","of","the","chromosome","that","always","segregates","at","the","first","division","of","meiosis",";","the","region","of","the","chromosome","in","which","no","crossing","over","occurs",".","At","the","start","of","M","phase",",","each","chromosome","consists","of","two","sister","chromatids","with","a","constriction","at","a","point","which","forms","the","centromere",".","During","late","prophase","two","kinetochores","assemble","on","each","centromere",",","one","kinetochore","on","each","sister","chromatid","."),4220374). assertion_content_comment('tOboGo_CentromericCoreChromatinAssembly',s("The","assembly","of","chromatin","into","the","specialized","structure","characteristic","of","the","centromeric","core","region",",","defined","by","the","presence","of","the","variant","histone","CENP-A","."),4073598). assertion_content_comment('tOboGo_CentromericDNABinding',s("Interacting","selectively","and","non-covalently","with","a","centromere",",","a","region","of","chromosome","where","the","spindle","fibers","attach","during","mitosis","and","meiosis","."),4235408). assertion_content_comment('tOboGo_CentromericHeterochromatinFormation',s("The","assembly","of","chromatin","into","heterochromatin","near","the","centromere","."),4060820). assertion_content_comment('tOboGo_CentromericHeterochromatin',s("A","region","of","heterochromatin","located","near","the","centromere","of","a","chromosome","."),3992982). assertion_content_comment('tOboGo_CentromericSisterChromatidCohesion',s("The","cell","cycle","process","in","which","the","sister","chromatids","of","a","replicated","chromosome","are","joined","along","the","length","of","the","centromeric","region","of","the","chromosome","."),4131012). assertion_content_comment('tOboGo_CentrosomalAndPronuclearRotation',s("The","rotation","of","centrosomes","and","associated","pronuclei","in","one-cell","embryos","such","as","those","of","Caenorhabditis","elegans",",","occurring","as","a","transition","between","pronuclear","migration","and","pronuclear","fusion","."),4072787). assertion_content_comment('tOboGo_CentrosomalCorona',s("An","amorphous","structure","surrounding","the","core","of","the","centrosome",",","from","which","microtubules","are","nucleated",";","contains","gamma-tubulin","."),4060339). assertion_content_comment('tOboGo_CentrosomalMitoticFactor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4221462). assertion_content_comment('tOboGo_CentrosomeCycle',s("The","cell","cycle","process","in","which","centrosome","duplication","and","separation","takes","place",".","The","centrosome","cycle","can","operate","with","a","considerable","degree","of","independence","from","other","processes","of","the","cell","cycle","."),4012520). assertion_content_comment('tOboGo_CentrosomeDuplication',s("The","replication","of","a","centrosome",",","a","structure","comprised","of","a","pair","of","centrioles","and","peri-centriolar","material","from","which","a","microtubule","spindle","apparatus","is","organized","."),4012522). assertion_content_comment('tOboGo_CentrosomeLocalization',s("Any","process","in","which","a","centrosome","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell","."),4121758). assertion_content_comment('tOboGo_CentrosomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","centrosome",",","a","structure","comprised","of","a","pair","of","centrioles","and","peri-centriolar","material","from","which","a","microtubule","spindle","apparatus","is","organized","."),4012507). assertion_content_comment('tOboGo_Centrosome',s("A","structure","comprised","of","a","core","structure","(","in","most","organisms",",","a","pair","of","centrioles",")","and","peripheral","material","from","which","a","microtubule-based","structure",",","such","as","a","spindle","apparatus",",","is","organized",".","Centrosomes","occur","close","to","the","nucleus","during","interphase","in","many","eukaryotic","cells",",","though","in","animal","cells","it","changes","continually","during","the","cell-division","cycle","."),3973795). assertion_content_comment('tOboGo_CentrosomeSeparation',s("The","process","in","which","duplicated","centrosome","components","move","away","from","each","other",".","The","centriole","pair","within","each","centrosome","becomes","part","of","a","separate","microtubule","organizing","center","that","nucleates","a","radial","array","of","microtubules","called","an","aster",".","The","two","asters","move","to","opposite","sides","of","the","nucleus","to","form","the","two","poles","of","the","mitotic","spindle","."),4012552). assertion_content_comment('tOboGo_CephalicFurrowFormation',s("Formation","of","a","partial","necklace","of","inturning","tissue","on","the","lateral","sides","of","the","embryo",",","along","the","dorsal-ventral","axis",".","This","furrow","demarcates","head","from","thorax","in","the","developing","protostome","."),4019587). assertion_content_comment('tOboGo_CephalosporinaseActivity',s("Catalysis","of","the","reaction",":","a","cephalosporin","+","H2O","=","a","substituted","beta-amino","acid","derivative","of","the","cephalosporin","."),4337857). assertion_content_comment('tOboGo_CephalosporinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","cephalosporin",",","any","of","large","class","of","tetracyclic","triterpene","broad-spectrum","antibiotics","similar","both","chemically","and","in","their","mode","of","action","to","penicillin",",","first","isolated","from","the","culture","filtrates","of","mediterranean","fungus","acremonium","(","cephalosporium","acremonium",")",",","and","effective","against","gram-positive","bacteria","."),4326449). assertion_content_comment('tOboGo_CephalosporinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","cephalosporin",",","any","of","large","class","of","tetracyclic","triterpene","broad-spectrum","antibiotics","similar","both","chemically","and","in","their","mode","of","action","to","penicillin",",","first","isolated","from","the","culture","filtrates","of","mediterranean","fungus","acremonium","(","cephalosporium","acremonium",")",",","and","effective","against","gram-positive","bacteria","."),4326437). assertion_content_comment('tOboGo_CeramidaseActivity',s("Catalysis","of","the","reaction",":","N-acylsphingosine","+","H2O","=","a","fatty","acid","+","sphingosine","."),4172810). 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assertion_content_comment('tOboGo_CerebellumMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","cerebellum","is","generated","and","organized",".","The","cerebellum","is","the","portion","of","the","brain","in","the","back","of","the","head","between","the","cerebrum","and","the","pons",".","The","cerebellum","controls","balance","for","walking","and","standing",",","modulates","the","force","and","range","of","movement","and","is","involved","in","the","learning","of","motor","skills","."),4043011). assertion_content_comment('tOboGo_CerebellumStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","cerebellum",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","cerebellum","is","the","portion","of","the","brain","in","the","back","of","the","head","between","the","cerebrum","and","the","pons",".","The","cerebellum","controls","balance","for","walking","and","standing",",","modulates","the","force","and","range","of","movement","and","is","involved","in","the","learning","of","motor","skills","."),4044612). assertion_content_comment('tOboGo_CerebellumVasculatureDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","vasculature","of","the","cerebellum","over","time",",","from","its","formation","to","the","mature","structure","."),4134809). assertion_content_comment('tOboGo_CerebellumVasculatureMorphogenesis',s("The","process","in","which","the","vasculature","of","the","cerebellum","is","generated","and","organized","."),4134820). assertion_content_comment('tOboGo_CerebralCortexCellMigration',s("The","orderly","movement","of","cells","from","one","site","to","another","in","the","cerebral","cortex","."),4049587). assertion_content_comment('tOboGo_CerebralCortexDevelopment',s("The","progression","of","the","cerebral","cortex","over","time","from","its","initial","formation","until","its","mature","state",".","The","cerebral","cortex","is","the","outer","layered","region","of","the","telencephalon","."),4046385). assertion_content_comment('tOboGo_CerebralCortexGABAergicInterneuronDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","cerebral","cortex","GABAergic","interneuron","over","time",",","from","initial","commitment","to","its","fate",",","to","the","fully","functional","differentiated","cell","."),4047687). assertion_content_comment('tOboGo_CerebralCortexGABAergicInterneuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","GABAergic","interneuron","residing","in","the","cerebral","cortex","."),4047654). assertion_content_comment('tOboGo_CerebralCortexGABAergicInterneuronFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","neuroblast","becomes","restricted","such","that","it","will","develop","into","a","GABAergic","interneuron","residing","in","the","cerebral","cortex","."),4047698). assertion_content_comment('tOboGo_CerebralCortexGABAergicInterneuronMigration',s("The","migration","of","GABAergic","interneuron","precursors","from","the","subpallium","to","the","cerebral","cortex","."),4050736). assertion_content_comment('tOboGo_CerebralCortexNeuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","neuron","residing","in","the","cerebral","cortex","."),4047401). assertion_content_comment('tOboGo_CerebralCortexRadialGliaGuidedMigration',s("The","radial","migration","of","neuronal","or","glial","precursor","cells","along","radial","glial","cells","during","the","development","of","the","cerebral","cortex","."),4049722). assertion_content_comment('tOboGo_CerebralCortexRadiallyOrientedCellMigration',s("The","migration","of","cells","in","the","developing","cerebral","cortex","in","which","cells","move","from","the","ventricular","and/or","subventricular","zone","toward","the","surface","of","the","brain","."),4049681). assertion_content_comment('tOboGo_CerebralCortexRegionalization',s("The","regionalization","process","that","results","in","the","creation","of","areas","within","the","cerebral","cortex","that","will","direct","the","behavior","of","cell","migration","and","differentiation","as","the","cortex","develops","."),4049561). assertion_content_comment('tOboGo_CerebralCortexTangentialMigration',s("The","migration","of","cells","in","the","cerebral","cortex","in","which","cells","move","orthogonally","to","the","direction","of","radial","migration","and","do","not","use","radial","glial","cell","processes","as","substrates","for","migration","."),4050181). assertion_content_comment('tOboGo_CerebrospinalFluidSecretion',s("The","regulated","release","of","cerebrospinal","fluid","(","CSF",")","from","the","choroid","plexus","of","the","lateral",",","third","and","fourth","ventricles",".","The","cerebrospinal","fluid","is","a","clear","liquid","that","located","within","the","ventricles",",","spinal","canal",",","and","subarachnoid","spaces","."),4338605). assertion_content_comment('tOboGo_CerevisinActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","proteins","with","broad","specificity",",","and","of","BZ-Arg-OET","&","gt",";","Ac-Tyr-OET",".","Does","not","hydrolyze","peptide","amides","."),4209355). assertion_content_comment('tOboGo_CervixDevelopment',s("The","reproductive","developmental","process","whose","specific","outcome","is","the","progression","of","the","cervix","over","time",",","from","its","formation","to","the","mature","structure","."),4159334). assertion_content_comment('tOboGo_CetraxateBenzylesteraseActivity',s("Catalysis","of","the","reaction",":","benzyl","cetraxate","+","H","(","2",")","O","=","benzyl","alcohol","+","cetraxate","+","H","(","+",")"),4373393). assertion_content_comment('tOboGo_CGMPBinding',s("Interacting","selectively","and","non-covalently","with","cGMP",",","the","nucleotide","cyclic","GMP","(","guanosine","3","'",",","5","'","-cyclophosphate",")"),4310780). assertion_content_comment('tOboGo_CGMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cyclic","GMP",",","guanosine","3","'",",","5","'","-phosphate","."),4050533). assertion_content_comment('tOboGo_CGMPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cyclic","GMP",",","guanosine","3","'",",","5","'","-phosphate","."),4050634). assertion_content_comment('tOboGo_CGMPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cyclic","GMP",",","guanosine","3","'",",","5","'","-phosphate","."),4050530). assertion_content_comment('tOboGo_CGMPTransport',s("The","directed","movement","of","cyclic","GMP","(","cGMP",")",",","into",",","out","of","or","within","a","cell","."),4176254). assertion_content_comment('tOboGo_ChalconeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","chalcone",",","phenyl","steryl","ketone","or","its","hydroxylated","derivatives","."),4260635). assertion_content_comment('tOboGo_ChalconeCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","chalcone",",","phenyl","steryl","ketone","or","its","hydroxylated","derivatives","."),4352944). assertion_content_comment('tOboGo_ChalconeIsomeraseActivity',s("Catalysis","of","the","reaction",":","a","chalcone","=","a","flavanone","."),4299624). assertion_content_comment('tOboGo_ChalconeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chalcones",",","phenyl","steryl","ketone","or","its","hydroxylated","derivatives","."),4260622). assertion_content_comment('tOboGo_ChannelActivity',s("Catalysis","of","energy-independent","facilitated","diffusion",",","mediated","by","passage","of","a","solute","through","a","transmembrane","aqueous","pore","or","channel",".","Stereospecificity","is","not","exhibited","but","this","transport","may","be","specific","for","a","particular","molecular","species","or","class","of","molecules","."),4107457). assertion_content_comment('tOboGo_ChannelInhibitorActivity',s("Stops",",","prevents",",","or","reduces","the","activity","of","a","channel",".","A","channel","catalyzes","energy-independent","facilitated","diffusion",",","mediated","by","passage","of","a","solute","through","a","transmembrane","aqueous","pore","or","channel","."),4173062). assertion_content_comment('tOboGo_ChannelRegulatorActivity',s("Modulates","the","activity","of","a","channel",".","A","channel","catalyzes","energy-independent","facilitated","diffusion",",","mediated","by","passage","of","a","solute","through","a","transmembrane","aqueous","pore","or","channel","."),4173060). assertion_content_comment('tOboGo_ChaperoneActivatorActivity',s("OBSOLETE",".","Increases","the","activity","of","a","molecular","chaperone","."),4311466). assertion_content_comment('tOboGo_ChaperoneActivity',s("OBSOLETE",".","Assists","in","the","correct","non-covalent","assembly","of","polypeptide-containing","structures","in","vivo",",","but","is","not","a","component","of","these","assembled","structures","when","they","are","performing","their","normal","biological","function","."),4192459). assertion_content_comment('tOboGo_ChaperoneBinding',s("Interacting","selectively","and","non-covalently","with","a","chaperone","protein",",","a","class","of","proteins","that","bind","to","nascent","or","unfolded","polypeptides","and","ensure","correct","folding","or","transport","."),4192350). assertion_content_comment('tOboGo_ChaperoneInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","a","molecular","chaperone","."),4311336). assertion_content_comment('tOboGo_ChaperoneMediatedProteinFoldingIndependentOfCofactor',s("The","process","of","assisting","in","the","correct","noncovalent","assembly","of","posttranslational","proteins","and","does","not","depend","on","additional","protein","cofactors",".","This","function","occurs","over","one","or","more","cycles","of","nucleotide-dependent","binding","and","release","."),4287127). assertion_content_comment('tOboGo_ChaperoneMediatedProteinFoldingRequiringCofactor',s("The","process","of","assisting","in","the","correct","posttranslational","noncovalent","assembly","of","proteins",",","which","is","dependent","on","additional","protein","cofactors",".","This","process","occurs","over","one","or","several","cycles","of","nucleotide","hydrolysis-dependent","binding","and","release","."),4287113). assertion_content_comment('tOboGo_ChaperoneRegulatorActivity',s("OBSOLETE",".","Modulates","the","activity","of","a","molecular","chaperone","."),4311436). assertion_content_comment('tOboGo_ChaperoninATPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",".","The","hydrolysis","of","ATP","involved","in","maintaining","an","unfolded","polypeptide","structure","before","folding","or","to","entry","into","mitochondria","and","chloroplasts","."),4192311). assertion_content_comment('tOboGo_ChaperoninATPaseComplex',s("Multisubunit","protein","complex","with","2x7","(","Type","I",",","in","most","cells",")","or","2x8","(","Type","II",",","in","Archaea",")","ATP-binding","sites","involved","in","maintaining","an","unfolded","polypeptide","structure","before","folding","or","to","entry","into","mitochondria","and","chloroplasts","."),4304919). assertion_content_comment('tOboGo_CHDomainBinding',s("Interacting","selectively","and","non-covalently","with","the","calponin","homology","domain","of","a","protein",",","a","domain","of","100","residues","that","occurs","in","signaling","and","cytoskeletal","proteins","."),4286834). assertion_content_comment('tOboGo_CheckpointClampComplex',s("Conserved","heterotrimeric","complex","of","PCNA-like","proteins","that","is","loaded","onto","DNA","at","sites","of","DNA","damage","."),4061331). assertion_content_comment('tOboGo_ChemicalHomeostasisWithinATissue',s("Any","process","involved","in","the","maintenance","of","the","internal","steady","state","of","the","amount","of","a","chemical","at","the","level","of","the","tissue","."),4317445). assertion_content_comment('tOboGo_ChemicalHomeostasisWithinRetina',s("Any","process","involved","in","the","maintenance","of","the","internal","steady","state","of","the","amount","of","a","chemical","at","the","level","of","the","retina","."),4330463). assertion_content_comment('tOboGo_ChemoattractantActivity',s("Providing","the","environmental","signal","that","initiates","the","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","of","that","signal","."),4306420). assertion_content_comment('tOboGo_ChemoattractionInvolvedInEmbryonicOlfactoryBulbInterneuronMigration',s("The","creation","and","reception","of","signals","that","result","in","the","migration","of","interneurons","up","a","concentration","gradient","towards","the","olfactory","bulb","."),4051203). assertion_content_comment('tOboGo_ChemoattractionInvolvedInInterneuronMigrationFromTheSubpalliumToTheCortex',s("The","creation","and","reception","of","signals","that","result","in","the","movement","of","interneurons","toward","the","signal",",","where","this","process","is","involved","in","migration","from","the","subpallium","to","the","cortex","."),4051215). assertion_content_comment('tOboGo_ChemoattractionInvolvedInPrecerebellarNeuronMigration',s("The","creation","and","reception","of","signals","that","guide","a","precerebellar","neuron","towards","their","signals",",","where","this","process","is","involved","in","tangential","migration","."),4047840). assertion_content_comment('tOboGo_ChemoattractionOfBranchiomotorAxon',s("The","process","in","which","a","branchiomotor","neuron","growth","cone","is","directed","to","a","specific","target","site","in","response","to","an","attractive","chemical","signal",".","Branchiomotor","neurons","are","located","in","the","hindbrain","and","innervate","branchial","arch-derived","muscles","that","control","jaw","movements",",","facial","expression",",","the","larynx",",","and","the","pharynx","."),4049599). assertion_content_comment('tOboGo_ChemoattractionOfBranchiomotorNeuronAxonInBranchialArchMesenchyme',s("The","process","in","which","a","branchiomotor","neuron","growth","cone","in","the","branchial","arch","mesenchyme","is","directed","to","a","specific","target","site","in","the","branchial","arch","mesenchyme","in","response","to","an","attractive","chemical","cue",".","Branchiomotor","neurons","are","located","in","the","hindbrain","and","innervate","branchial","arch-derived","muscles","that","control","jaw","movements",",","facial","expression",",","the","larynx",",","and","the","pharynx","."),4049646). assertion_content_comment('tOboGo_ChemoattractionOfBranchiomotorNeuronAxonInNeuralTube',s("The","process","in","which","a","branchiomotor","neuron","growth","cone","in","the","neural","tube","is","directed","to","a","specific","target","site","in","the","neural","tube","in","response","to","an","attractive","chemical","cue",".","Branchiomotor","neurons","are","located","in","the","hindbrain","and","innervate","branchial","arch-derived","muscles","that","control","jaw","movements",",","facial","expression",",","the","larynx",",","and","the","pharynx","."),4049658). assertion_content_comment('tOboGo_ChemokineActivity',s("The","function","of","a","family","of","chemotactic","pro-inflammatory","activation-inducible","cytokines","acting","primarily","upon","hemopoietic","cells","in","immunoregulatory","processes",";","all","chemokines","possess","a","number","of","conserved","cysteine","residues","involved","in","intramolecular","disulfide","bond","formation","."),4247419). assertion_content_comment('tOboGo_ChemokineBinding',s("Interacting","selectively","and","non-covalently","with","a","chemokine",",","any","of","a","subgroup","of","cytokines","which","act","primarily","on","hemopoietic","cells","in","acute","and","inflammatory","processes","and","other","immunoregulatory","functions","."),4169236). assertion_content_comment('tOboGo_ChemokineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","chemokines",",","any","of","a","subgroup","of","cytokines","which","act","primarily","on","hemopoietic","cells","in","acute","and","inflammatory","processes","and","other","immunoregulatory","functions","."),4081545). assertion_content_comment('tOboGo_ChemokineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chemokines",",","any","of","a","subgroup","of","cytokines","which","act","primarily","on","hemopoietic","cells","in","acute","and","inflammatory","processes","and","other","immunoregulatory","functions","."),4081541). assertion_content_comment('tOboGo_ChemokineProduction',s("The","appearance","of","a","chemokine","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4066935). assertion_content_comment('tOboGo_ChemokineReceptorActivity',s("Combining","with","chemokines",",","small","chemoattractant","molecules","normally","used","to","stimulate","leukocytes",",","to","initiate","a","change","in","cell","activity","."),4197850). assertion_content_comment('tOboGo_ChemokineReceptorAntagonistActivity',s("Interacts","with","chemokine","receptors","to","reduce","the","action","of","a","chemokine","."),4358023). assertion_content_comment('tOboGo_ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","any","chemokine","receptor","."),4217466). assertion_content_comment('tOboGo_ChemokineReceptorTransportOutOfMembraneRaft',s("The","directed","movement","of","a","chemokine","receptor","out","of","a","membrane","raft","."),4332300). assertion_content_comment('tOboGo_ChemokineReceptorTransportWithinLipidBilayer',s("The","directed","movement","of","a","chemokine","receptor","within","a","lipid","bilayer","."),4332297). assertion_content_comment('tOboGo_ChemokineSecretion',s("The","regulated","release","of","chemokines","from","a","cell","or","group","of","cells","."),4084056). assertion_content_comment('tOboGo_Chemokinesis',s("A","response","by","a","motile","cell","to","a","soluble","chemical","that","involves","an","increase","or","decrease","in","speed","(","positive","or","negative","orthokinesis",")","or","of","frequency","of","movement","or","a","change","in","the","frequency","or","magnitude","of","turning","behavior","(","klinokinesis",")"),4313355). assertion_content_comment('tOboGo_ChemoreceptorSignalingPathwayInvolvedInRegulationOfBloodPressure',s("A","series","of","reactions","within","the","cell","that","occur","as","a","result","of","a","single","trigger","reaction","or","compound","interacting","with","a","chemoreceptor","resulting","in","a","modulation","of","the","force","with","which","blood","travels","through","the","circulatory","system",".","Chemoreceptors","respond","to","oxygen",",","carbon","dioxide","and","hydrogen","ions","."),3991643). assertion_content_comment('tOboGo_ChemorepellentActivity',s("Providing","the","environmental","signal","that","initiates","the","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","of","that","signal","."),4299688). assertion_content_comment('tOboGo_ChemorepulsionInvolvedInEmbryonicOlfactoryBulbInterneuronMigration',s("The","creation","and","reception","of","signals","that","guide","olfactory","bulb","interneurons","down","concentration","gradients","towards","the","olfactory","bulb","."),4051097). assertion_content_comment('tOboGo_ChemorepulsionInvolvedInInterneuronMigrationFromTheSubpalliumToTheCortex',s("The","creation","and","reception","of","signals","that","result","in","the","movement","of","interneurons","away","from","the","signal","during","migration","from","the","subpallium","to","the","cortex","."),4050905). assertion_content_comment('tOboGo_ChemorepulsionInvolvedInPostnatalOlfactoryBulbInterneuronMigration',s("The","creation","and","reception","of","signals","that","repel","olfactory","bulb","interneurons","from","the","subventricular","zone","as","a","component","process","in","tangential","migration","."),4051191). assertion_content_comment('tOboGo_ChemorepulsionInvolvedInPrecerebellarNeuronMigration',s("The","creation","and","reception","of","signals","that","repel","a","precerebellar","neuron","as","a","component","of","the","process","of","tangential","migration","."),4047828). assertion_content_comment('tOboGo_ChemorepulsionOfBranchiomotorAxon',s("The","process","in","which","a","branchiomotor","neuron","growth","cone","is","directed","to","a","specific","target","site","in","response","to","a","repulsive","chemical","cue",".","Branchiomotor","neurons","are","located","in","the","hindbrain","and","innervate","branchial","arch-derived","muscles","that","control","jaw","movements",",","facial","expression",",","the","larynx",",","and","the","pharynx","."),4049612). assertion_content_comment('tOboGo_ChemorepulsionOfBranchiomotorNeuronAxonInBranchialArchMesenchyme',s("The","process","in","which","a","branchiomotor","neuron","growth","cone","in","the","branchial","arch","mesenchyme","is","directed","to","a","specific","target","site","in","the","branchial","arch","mesenchyme","in","response","to","a","repulsive","chemical","cue",".","Branchiomotor","neurons","are","located","in","the","hindbrain","and","innervate","branchial","arch-derived","muscles","that","control","jaw","movements",",","facial","expression",",","the","larynx",",","and","the","pharynx","."),4049634). assertion_content_comment('tOboGo_ChemorepulsionOfBranchiomotorNeuronAxonInNeuralTube',s("The","process","in","which","a","branchiomotor","neuron","growth","cone","in","the","neural","tube","is","directed","to","a","specific","target","site","in","the","neural","tube","in","response","to","a","repulsive","chemical","cue",".","Branchiomotor","neurons","are","located","in","the","hindbrain","and","innervate","branchial","arch-derived","muscles","that","control","jaw","movements",",","facial","expression",",","the","larynx",",","and","the","pharynx","."),4049670). assertion_content_comment('tOboGo_ChemosensoryBehavior',s("Behavior","that","is","dependent","upon","the","sensation","of","chemicals","."),4150510). assertion_content_comment('tOboGo_ChemosensoryJumpBehavior',s("The","sudden",",","usually","upward",",","movement","off","the","ground","or","other","surface","through","sudden","muscular","effort","in","the","legs",",","following","exposure","to","a","chemical","substance","."),4235040). assertion_content_comment('tOboGo_ChemotaxisInEnvironmentOfOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","on",",","within","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196622). assertion_content_comment('tOboGo_ChemotaxisInHostEnvironment',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","on",",","within","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197344). assertion_content_comment('tOboGo_ChemotaxisInOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","within","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196664). assertion_content_comment('tOboGo_ChemotaxisOnOrNearHostInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197349). assertion_content_comment('tOboGo_ChemotaxisOnOrNearOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","on","or","near","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196640). 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assertion_content_comment('tOboGo_ChemotaxisToFolate',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","the","presence","of","folate","."),4318231). assertion_content_comment('tOboGo_ChemotaxisToOxidizableSubstrate',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","the","presence","of","an","oxidizable","substrate",",","for","example",",","fructose","."),4312892). assertion_content_comment('tOboGo_ChemotaxisWithinHost',s("The","directed","movement","of","a","motile","cell","or","organism","in","response","to","a","specific","chemical","concentration","gradient","within","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197362). 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assertion_content_comment('tOboGo_ChitinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues","."),4010221). assertion_content_comment('tOboGo_ChitinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues","."),4075571). assertion_content_comment('tOboGo_ChitinDeacetylaseActivity',s("Catalysis","of","the","reaction",":","chitin","+","H2O","=","chitosan","+","acetate","."),4212241). assertion_content_comment('tOboGo_ChitinLocalization',s("A","process","in","which","chitin","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4225544). assertion_content_comment('tOboGo_ChitinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues","."),4010216). assertion_content_comment('tOboGo_ChitinSynthaseActivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-D-glucosamine","+","(","(","1",",","4",")","-","(","N-acetyl-beta-D-glucosaminyl",")",")","(","n",")","=","UDP","+","(","(","1",",","4",")","-","(","N-acetyl-beta-D-glucosaminyl",")",")","(","n","+","1",")"),4211860). assertion_content_comment('tOboGo_ChitosanaseActivity',s("Catalysis","of","the","endohydrolysis","of","beta-1",",","4-linkages","between","N-acetyl-D-glucosamine","and","D-glucosamine","residues","in","a","partly","acetylated","chitosan","."),4302532). assertion_content_comment('tOboGo_ChitosanLayerOfSporeWall',s("The","second","outermost","layer","of","the","spore","wall",",","as","described","in","Saccharomyces","."),4007008). assertion_content_comment('tOboGo_ChitosomeMembrane',s("The","lipid","bilayer","surrounding","a","chitosome","."),4051748). assertion_content_comment('tOboGo_Chitosome',s("An","intracellular","membrane-bounded","particle","found","in","fungi","and","containing","chitin","synthase",";","it","synthesizes","chitin","microfibrils",".","Chitin","synthase","activity","exists","in","chitosomes","and","they","are","proposed","to","act","as","a","reservoir","for","regulated","transport","of","chitin","synthase","enzymes","to","the","division","septum","."),4051738). assertion_content_comment('tOboGo_ChlamydosporeFormation',s("The","process","whose","specific","outcome","is","the","progression","of","the","chlamydospore","over","time",",","from","its","formation","to","the","mature","structure",".","A","chlamydospores","is","a","mitotic","(","asexual",")","one-celled","spore",",","produced","primarily","for","survival",",","not","dispersal",",","originating","endogenously","and","singly","within","part","of","a","pre-existing","cell","and","possessing","an","inner","secondary","and","often","thickened","cell","wall",".","An","example","of","this","is","found","in","Candida","albicans","."),4360361). assertion_content_comment('tOboGo_ChlamydosporeSeptinFilamentArray',s("Arrays","of","septin","filaments",",","or","bars",",","found","in","a","series","of","filamentous","structures",".","Observed","in","the","chlamydospore","membrane","during","chlamydospore","formation","."),4329498). assertion_content_comment('tOboGo_ChloralHydrateDehydrogenaseActivity',s("Catalysis","of","the","reactions",":","chloral","hydrate","=","3","H","+","+","2","e-","+","trichloroacetate",",","and","chloral","hydrate","+","H2","=","H2O","+","trichloroethanol","."),4281649). assertion_content_comment('tOboGo_ChloramphenicolTransporterActivity',s("Enables","the","directed","movement","of","chloramphenicol",",","a","broad-spectrum","antibiotic","that","inhibits","bacterial","protein","synthesis",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4315086). assertion_content_comment('tOboGo_ChloramphenicolTransport',s("The","directed","movement","of","chloramphenicol",",","a","broad-spectrum","antibiotic","that","inhibits","bacterial","protein","synthesis",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4314910). assertion_content_comment('tOboGo_ChlorateReductaseActivity',s("Catalysis","of","the","reaction",":","AH","(","2",")","+","chlorate","=","A","+","chlorite","+","H","(","2",")","O","+","H","(","+",")"),4365541). assertion_content_comment('tOboGo_ChlorateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","chlorate",",","ClO3-",",","from","one","side","of","a","membrane","to","the","other","."),4297459). assertion_content_comment('tOboGo_ChlorateTransport',s("The","directed","movement","of","chlorate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290927). assertion_content_comment('tOboGo_ChlordeconeReductaseActivity',s("Catalysis","of","the","reaction",":","chlordecone","alcohol","+","NADP","(","+",")","=","chlordecone","+","H","(","+",")","+","NADPH","."),4373372). assertion_content_comment('tOboGo_ChlorideChannelActivity',s("Catalysis","of","facilitated","diffusion","of","a","chloride","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel","without","evidence","for","a","carrier-mediated","mechanism","."),4158692). assertion_content_comment('tOboGo_ChlorideChannelComplex',s("An","ion","channel","complex","through","which","chloride","ions","pass","."),4040780). assertion_content_comment('tOboGo_ChlorideChannelInhibitorActivity',s("Stops",",","prevents",",","or","reduces","the","activity","of","a","chloride","channel","."),4233544). assertion_content_comment('tOboGo_ChlorideChannelRegulatorActivity',s("Modulates","the","activity","of","a","chloride","channel","."),4233542). assertion_content_comment('tOboGo_ChlorideIonBinding',s("Interacting","selectively","and","non-covalently","with","chloride","ions","(","Cl-",")"),4319546). 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assertion_content_comment('tOboGo_ChlorinatedHydrocarbonCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","chlorinated","hydrocarbons",",","any","hydrocarbon","with","one","or","more","chlorine","atoms","attached","to","it","."),4238301). assertion_content_comment('tOboGo_ChlorinatedHydrocarbonMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chlorinated","hydrocarbons",",","any","hydrocarbon","with","one","or","more","chlorine","atoms","attached","to","it","."),4045251). assertion_content_comment('tOboGo_ChlorobenzeneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","2",",","3-unsubstituted","benzenoid","+","O2","+","NAD","(","P",")","H","+","H","+","=","2",",","3-cis-dihydroxydihydrobenzenoid","+","NAD","(","P",")","+","Substrates","include","1",",","4-dichlorobenzene","(","forms","3",",","6-dichloro-cis-1",",","2-dihydroxycyclohexa-3",",","5-diene",")",",","1",",","2",",","3",",","4-tetrachlorobenzene","(","forms","cis-chlorobenzene","dihydrodiol",")","and","1",",","2",",","4-trichlorobenzene","(","forms","3",",","4",",","6-trichloro-cis-1",",","2-dihydroxycyclohexa-3",",","5-diene",")"),4276925). assertion_content_comment('tOboGo_ChlorobenzeneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chlorobenzene",",","a","derivative","of","benzene","with","a","chlorine","atoms","attached","to","the","ring",".","It","is","a","colorless","liquid","that","is","manufactured","for","use","as","a","solvent",".","It","quickly","evaporates","in","the","air","and","is","degraded","by","hydroxyl","radicals","that","are","produced","photochemically",".","The","gas","acts","as","a","source","of","ClOx",",","which","helps","in","the","breakdown","of","stratospheric","ozone","."),4272334). assertion_content_comment('tOboGo_ChlorogenateHydrolaseActivity',s("Catalysis","of","the","reaction",":","chlorogenate","+","H","(","2",")","O","=","(","-",")","-quinate","+","cis-caffeate","+","H","(","+",")"),4373351). assertion_content_comment('tOboGo_ChloromuconateCycloisomeraseActivity',s("Catalysis","of","the","reaction",":","2-chloro-2",",","5-dihydro-5-oxofuran-2-acetate","=","3-chloro-cis",",","cis-muconate","."),4273719). assertion_content_comment('tOboGo_ChlorophyllABiosyntheticProcess',s("The","chemical","reactions","and","pathways","leading","to","the","formation","of","chlorophyll","a","."),4338955). assertion_content_comment('tOboGo_ChlorophyllABiosyntheticProcessViaPhytylDiphosphate',s("The","chemical","reactions","and","pathways","leading","to","the","formation","of","chlorophyll","a",",","via","the","intermediate","phytyl","diphosphate","."),4339017). assertion_content_comment('tOboGo_ChlorophyllACatabolicProcess',s("The","chemical","reactions","and","pathways","leading","to","the","breakdown","of","chlorophyll","a","."),4338990). assertion_content_comment('tOboGo_ChlorophyllAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chlorophyll","a","."),4338943). assertion_content_comment('tOboGo_ChlorophyllaseActivity',s("Catalysis","of","the","reaction",":","chlorophyll","+","H2O","=","phytol","+","chlorophyllide","."),4373362). assertion_content_comment('tOboGo_ChlorophyllBinding',s("Interacting","selectively","and","non-covalently","with","chlorophyll",";","any","compound","of","magnesium","complexed","in","a","porphyrin","(","tetrapyrrole",")","ring","and","which","functions","as","a","photosynthetic","pigment","."),4304141). assertion_content_comment('tOboGo_ChlorophyllBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","chlorophyll",",","any","compound","of","magnesium","complexed","in","a","porphyrin","(","tetrapyrrole",")","ring","and","which","functions","as","a","photosynthetic","pigment",",","from","less","complex","precursors","."),4031283). assertion_content_comment('tOboGo_ChlorophyllCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","chlorophyll",",","any","compound","of","magnesium","complexed","in","a","porphyrin","(","tetrapyrrole",")","ring","and","which","functions","as","a","photosynthetic","pigment",",","into","less","complex","products","."),4031795). assertion_content_comment('tOboGo_ChlorophyllCataboliteTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","chlorophyll","catabolites","such","as","non-fluorescent","chlorophyll","catabolites","(","NCCs",")",",","from","one","side","of","the","membrane","to","the","other","."),4335170). assertion_content_comment('tOboGo_ChlorophyllCycle',s("A","cyclic","series","of","interconversions","involving","chlorophyll","a",",","chlorophyll","b","and","several","chlorophyllide","intermediates","."),4338756). assertion_content_comment('tOboGo_ChlorophyllideAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chlorophyllide","a",",","a","chlorophyll","lacking","the","terpenoid","side","chain",",","which","is","the","functional","parent","of","chlorophyll","a","."),4191763). assertion_content_comment('tOboGo_ChlorophyllideAOxygenaseActivity',s("Catalysis","of","the","reaction",":","chlorophyllide","a","+","NADPH","+","O2","+","2","H","+","=","7-hydroxychlorophyllide","a","+","NADP","+","+","H2O","."),4190944). assertion_content_comment('tOboGo_ChlorophyllideAOxygenaseOverallActivity',s("Catalysis","of","the","reactions",":","chlorophyllide","a","+","O2","+","NADPH","+","H","+","=","7-hydroxychlorophyllide","a","+","H2O","+","NADP","+",";","and","7-hydroxychlorophyllide","a","+","O2","+","NADPH","+","H","+","=","chlorophyllide","b","+","2","H2O","+","NADP","+"),4335282). assertion_content_comment('tOboGo_ChlorophyllIdeBReductaseActivity',s("Catalysis","of","the","reaction",":","71-hydroxychlorophyll","(","ide",")","a","+","NAD","(","P",")","+","=","chlorophyll","(","ide",")","b","+","NAD","(","P",")","H","+","H","+"),4359468). assertion_content_comment('tOboGo_ChlorophyllideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chlorophyllides",",","any","chlorophyll","lacking","the","terpenoid","side","chain","such","as","phytyl","or","farnesyl","."),4191729). assertion_content_comment('tOboGo_ChlorophyllMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chlorophyll",",","any","compound","of","magnesium","complexed","in","a","porphyrin","(","tetrapyrrole",")","ring","and","which","functions","as","a","photosynthetic","pigment","."),4031279). assertion_content_comment('tOboGo_ChlorophyllSynthetaseActivity',s("Catalysis","of","the","reaction",":","chlorophyllide","a","+","2","H","(","+",")","+","phytyl","diphosphate","=","chlorophyll","a","+","diphosphate","."),4351345). assertion_content_comment('tOboGo_ChloroplastAccumulationMovement',s("The","relocation","process","in","which","chloroplasts","in","photosynthetic","cells","move","toward","a","brighter","area","in","a","cell","to","optimize","photosynthesis","."),4262181). assertion_content_comment('tOboGo_ChloroplastADPGPyrophosphorylaseComplex',s("An","ADPG","pyrophosphorylase","complex","found","in","the","chloroplast","."),4307512). assertion_content_comment('tOboGo_ChloroplastATPSynthaseComplex',s("The","protein","complex","that","catalyzes","the","phosphorylation","of","ADP","to","ATP","in","chloroplasts","."),4023434). assertion_content_comment('tOboGo_ChloroplastAvoidanceMovement',s("The","relocation","process","in","which","chloroplasts","in","photosynthetic","cells","avoid","strong","light","and","move","away","from","it","in","order","to","preserve","the","photosynthetic","machinery","."),4262171). assertion_content_comment('tOboGo_ChloroplastChromosome',s("A","circular","DNA","molecule","containing","chloroplast","encoded","genes","."),4077728). assertion_content_comment('tOboGo_ChloroplastElongation',s("Expansion","of","the","chloroplast","that","usually","precedes","division","."),4333987). assertion_content_comment('tOboGo_ChloroplastEnvelope',s("The","double","lipid","bilayer","enclosing","the","chloroplast","and","separating","its","contents","from","the","rest","of","the","cytoplasm",";","includes","the","intermembrane","space","."),4030818). assertion_content_comment('tOboGo_ChloroplastFission',s("The","division","of","a","chloroplast","within","a","cell","to","form","two","or","more","separate","chloroplast","compartments",".","This","division","occurs","independently","of","mitosis","."),4330030). assertion_content_comment('tOboGo_ChloroplasticEndopeptidaseClpComplex',s("A","Clp","endopeptidase","complex","located","in","the","chloroplast","."),4021619). assertion_content_comment('tOboGo_ChloroplastInnerMembrane',s("The","inner",",","i.e",".","lumen-facing",",","lipid","bilayer","of","the","chloroplast","envelope",";","also","faces","the","chloroplast","stroma","."),4057283). assertion_content_comment('tOboGo_ChloroplastIntermembraneSpace',s("The","region","between","the","inner","and","outer","lipid","bilayers","of","a","chloroplast","envelope","."),4057754). assertion_content_comment('tOboGo_ChloroplastIsoamylaseComplex',s("A","protein","complex","whose","composition","varies","amongst","species",";","in","rice","it","probably","exists","in","a","homo-tetramer","to","homo-hexamer","form","and","in","Gram","negative","bacteria","as","a","dimer",".","Functions","in","the","hydrolysis","of","alpha-","(","1",",","6",")","-D-glucosidic","branch","linkages",".","Isoamylases","in","plants","are","intracellular","and","probably","chloroplast","localized","."),4332085). assertion_content_comment('tOboGo_ChloroplastLargeRibosomalSubunit',s("The","large","subunit","of","a","ribosome","contained","within","a","chloroplast","."),4053584). assertion_content_comment('tOboGo_ChloroplastLocalization',s("Any","process","in","which","a","chloroplast","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell",".","A","chloroplast","is","a","chlorophyll-containing","plastid","found","in","cells","of","algae","and","higher","plants","."),4245504). assertion_content_comment('tOboGo_ChloroplastMembrane',s("Either","of","the","lipid","bilayers","that","surround","a","chloroplast","and","form","the","chloroplast","envelope","."),4030820). assertion_content_comment('tOboGo_ChloroplastMRNAProcessing',s("Steps","involved","in","processing","precursor","RNAs","arising","from","transcription","of","operons","in","the","chloroplast","genome","into","mature","mRNAs","."),4335606). assertion_content_comment('tOboGo_ChloroplastNucleoid',s("The","region","of","a","chloroplast","to","which","the","DNA","is","confined","."),4077665). assertion_content_comment('tOboGo_ChloroplastOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","chloroplast","."),4063500). assertion_content_comment('tOboGo_ChloroplastOuterMembrane',s("The","outer",",","i.e",".","cytoplasm-facing",",","lipid","bilayer","of","the","chloroplast","envelope","."),4030822). assertion_content_comment('tOboGo_ChloroplastOuterMembraneTranslocon',s("The","protein","transport","machinery","of","the","chloroplast","outer","membrane","that","contains","at","least","three","components","Toc159",",","Toc75","and","Toc34",",","interacts","with","precursor","proteins","which","are","imported","into","the","chloroplast","in","a","GTP","dependant","manner","."),4030835). assertion_content_comment('tOboGo_ChloroplastPart',s("Any","constituent","part","of","a","chloroplast",",","a","chlorophyll-containing","plastid","with","thylakoids","organized","into","grana","and","frets",",","or","stroma","thylakoids",",","and","embedded","in","a","stroma","."),4021594). assertion_content_comment('tOboGo_ChloroplastPhotosystemII',s("An","integral","chloroplast","membrane","complex","containing","the","P680","reaction","center",".","In","the","light",",","PSII","functions","as","a","water-plastoquinone","oxidoreductase",",","transferring","electrons","from","water","to","plastoquinone","."),4052935). assertion_content_comment('tOboGo_ChloroplastPhotosystemI',s("Photosystem","located","in","the","chloroplast","that","functions","as","a","light-dependent","plastocyanin-ferredoxin","oxidoreductase",",","transferring","electrons","from","plastocyanin","to","ferredoxin",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),4052972). assertion_content_comment('tOboGo_ChloroplastRelocation',s("The","process","in","which","chloroplasts","in","photosynthetic","cells","migrate","toward","illuminated","sites","to","optimize","photosynthesis","and","move","away","from","excessively","illuminated","areas","to","protect","the","photosynthetic","machinery","."),4262138). assertion_content_comment('tOboGo_ChloroplastRibosome',s("A","ribosome","contained","within","a","chloroplast","."),4053573). assertion_content_comment('tOboGo_ChloroplastRibuloseBisphosphateCarboxylaseComplexBiogenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","chloroplast","ribulose","bisphosphate","carboxylase","(","RubisCO",")","complex",".","Includes","the","synthesis","of","the","constituent","protein","molecules",",","and","those","protein","modifications","that","are","involved","in","synthesis","or","assembly","of","the","complex","."),4181146). assertion_content_comment('tOboGo_ChloroplastRibuloseBisphosphateCarboxylaseComplex',s("A","complex",",","located","in","the","chloroplast",",","containing","either","both","large","and","small","subunits","or","just","small","subunits","which","carries","out","the","activity","of","producing","3-phosphoglycerate","from","carbon","dioxide","and","ribulose-1",",","5-bisphosphate",".","An","example","of","this","component","is","found","in","Arabidopsis","thaliana","."),4022908). assertion_content_comment('tOboGo_ChloroplastRNAProcessing',s("The","conversion","of","a","primary","RNA","molecule","transcribed","from","a","chloroplast","genome","into","one","or","more","mature","RNA","molecules","."),4321317). assertion_content_comment('tOboGo_Chloroplast',s("A","chlorophyll-containing","plastid","with","thylakoids","organized","into","grana","and","frets",",","or","stroma","thylakoids",",","and","embedded","in","a","stroma","."),4021592). assertion_content_comment('tOboGo_ChloroplastSmallRibosomalSubunit',s("The","small","subunit","of","a","ribosome","contained","within","a","chloroplast","."),4053597). assertion_content_comment('tOboGo_ChloroplastStarchGrain',s("Plant","storage","body","for","amylose","and","amylopectin",",","1-100um","in","diameter",",","and","located","in","chloroplasts",".","Also","contains","small","amounts","of","enzymes",",","amino","acids",",","lipids","and","nucleic","acids",".","The","shape","of","the","grain","varies","widely","amongst","species",",","but","is","often","spherical","or","disk-shaped","."),4261592). assertion_content_comment('tOboGo_ChloroplastStromalThylakoid',s("Unstacked","thylakoids","that","connect","the","grana","stacks","through","the","stroma","."),4023359). assertion_content_comment('tOboGo_ChloroplastStroma',s("The","space","enclosed","by","the","double","membrane","of","a","chloroplast","but","excluding","the","thylakoid","space",".","It","contains","DNA",",","ribosomes","and","some","temporary","products","of","photosynthesis","."),4021596). assertion_content_comment('tOboGo_ChloroplastTargetingSequenceBinding',s("Interacting","selectively","and","non-covalently","with","a","chloroplast","targeting","sequence",",","a","specific","peptide","sequence","that","acts","as","a","signal","to","localize","the","protein","within","the","chloroplast","."),4307492). assertion_content_comment('tOboGo_ChloroplastThylakoidLumen',s("The","cavity","enclosed","within","the","chloroplast","thylakoid","membrane",".","An","example","of","this","component","is","found","in","Arabidopsis","thaliana","."),4023421). assertion_content_comment('tOboGo_ChloroplastThylakoidMembrane',s("The","pigmented","membrane","of","a","chloroplast","thylakoid",".","An","example","of","this","component","is","found","in","Arabidopsis","thaliana","."),4022760). assertion_content_comment('tOboGo_ChloroplastThylakoid',s("Sac-like","membranous","structures","(","cisternae",")","in","a","chloroplast","combined","into","stacks","(","grana",")","and","present","singly","in","the","stroma","(","stroma","thylakoids","or","frets",")","as","interconnections","between","grana",".","An","example","of","this","component","is","found","in","Arabidopsis","thaliana","."),4022758). assertion_content_comment('tOboGo_Chlororespiration',s("A","respiratory","electron","flow","(","from","NAD","(","P",")","H","to","plastoquinone","(","PQ",")","and","O2",")","involving","both","a","nonphotochemical","reduction","and","re-oxidation","of","PQ","pool","."),4332901). assertion_content_comment('tOboGo_ChlorosomeEnvelope',s("The","structure",",","composed","of","a","monolayer","of","glycolipids","with","embedded","proteins",",","that","encloses","the","pigments","and","other","contents","of","the","chlorosome","."),4065767). assertion_content_comment('tOboGo_Chlorosome',s("A","large","enclosure","of","aggregated","pigment",",","typically","bacteriochlorophyll","c","(","BChl","c",")",",","that","acts","as","a","light-harvesting","antenna","structure","and","is","characteristic","of","green","photosynthetic","bacteria","(","e.g",".","Chlorobiaceae",")","The","BChl","aggregates","are","organized","into","lamellar","elements","by","pigment-pigment","rather","than","pigment-protein","interactions",".","Chlorosomes","also","contain","BChl","a",",","carotenoids",",","quinones",",","lipids",",","and","proteins",",","and","are","attached","to","the","cytoplasmic","membrane","via","a","BChl","a-containing","protein","baseplate","."),4065747). assertion_content_comment('tOboGo_CholecystokininReceptorActivity',s("Combining","with","a","cholecystokinin",",","any","of","a","group","of","related","neuropeptides","secreted","by","the","upper","intestinal","mucosa","and","also","found","in","the","central","nervous","system",",","to","initiate","a","change","in","cell","activity","."),4197829). assertion_content_comment('tOboGo_CholecystokininReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","cholecystokinin","receptor","."),4323351). assertion_content_comment('tOboGo_CholesterolBinding',s("Interacting","selectively","and","non-covalently","with","cholesterol","(","cholest-5-en-3-beta-ol",")",";","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4292578). assertion_content_comment('tOboGo_CholesterolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4088762). assertion_content_comment('tOboGo_CholesterolBiosyntheticProcessViaDesmosterol',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cholesterol",",","cholest-5-en-3","beta-ol",",","via","the","intermediate","desmosterol","."),4339304). assertion_content_comment('tOboGo_CholesterolBiosyntheticProcessViaLathosterol',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cholesterol",",","cholest-5-en-3","beta-ol",",","via","the","intermediate","lathosterol","."),4339676). assertion_content_comment('tOboGo_CholesterolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4229652). assertion_content_comment('tOboGo_CholesterolEfflux',s("The","directed","movement","of","cholesterol",",","cholest-5-en-3-beta-ol",",","out","of","a","cell","or","organelle","."),4037291). assertion_content_comment('tOboGo_CholesterolEsterHydrolysisInvolvedInCholesterolTransport',s("The","cholesterol","metabolic","process","in","which","cholesterol","esters","are","hydrolyzed","into","free","fatty","acids","and","cholesterol","in","the","lysosome","that","contributes","to","intracellular","cholesterol","transport","."),4149027). assertion_content_comment('tOboGo_CholesterolEsterification',s("A","lipid","modification","process","in","which","a","sterol","ester","is","formed","by","the","combination","of","a","carboxylic","acid","(","often","a","fatty","acid",")","and","cholesterol",".","In","the","blood","this","process","is","associated","with","the","conversion","of","free","cholesterol","into","cholesteryl","ester",",","which","is","then","sequestered","into","the","core","of","a","lipoprotein","particle","."),4037131). assertion_content_comment('tOboGo_CholesterolHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","cholesterol","within","an","organism","or","cell","."),4141357). assertion_content_comment('tOboGo_CholesterolImport',s("The","directed","movement","of","cholesterol","into","a","cell","or","organelle","."),4111647). assertion_content_comment('tOboGo_CholesterolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones",".","It","is","a","component","of","the","plasma","membrane","lipid","bilayer","and","of","plasma","lipoproteins","and","can","be","found","in","all","animal","tissues","."),4088758). assertion_content_comment('tOboGo_CholesterolOxidaseActivity',s("Catalysis","of","the","reaction",":","cholesterol","+","O","(","2",")","=","cholest-4-en-3-one","+","H","(","2",")","O","(","2",")"),4302407). assertion_content_comment('tOboGo_CholesterolStorage',s("The","accumulation","and","maintenance","in","cells","or","tissues","of","cholesterol",",","cholest-5-en-3","beta-ol",",","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4037391). assertion_content_comment('tOboGo_CholesterolSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","cholesterol","=","adenosine","3","'",",","5","'","-bisphosphate","+","cholesterol","sulfate","."),4183097). assertion_content_comment('tOboGo_CholesterolTransporterActivity',s("Enables","the","directed","movement","of","cholesterol","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Cholesterol","is","the","principal","sterol","of","vertebrates","and","the","precursor","of","many","steroids",",","including","bile","acids","and","steroid","hormones","."),4267498). assertion_content_comment('tOboGo_CholesterolTransportInvolvedInCholesterolStorage',s("The","directed","movement","of","cholesterol","into","cells","that","is","part","of","their","accumulation","and","maintenance","."),4037404). assertion_content_comment('tOboGo_CholesterolTransport',s("The","directed","movement","of","cholesterol",",","cholest-5-en-3-beta-ol",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4037289). assertion_content_comment('tOboGo_CholineBinding',s("Interacting","selectively","and","non-covalently","with","choline",",","the","amine","2-hydroxy-N",",","N",",","N-trimethylethanaminium","."),4337961). assertion_content_comment('tOboGo_CholineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","choline","(","2-hydroxyethyltrimethylammonium",")",",","an","amino","alcohol","that","occurs","widely","in","living","organisms","as","a","constituent","of","certain","types","of","phospholipids","and","in","the","neurotransmitter","acetylcholine","."),4312519). assertion_content_comment('tOboGo_CholineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","choline","(","2-hydroxyethyltrimethylammonium",")",",","an","amino","alcohol","that","occurs","widely","in","living","organisms","as","a","constituent","of","certain","types","of","phospholipids","and","in","the","neurotransmitter","acetylcholine","."),4312504). assertion_content_comment('tOboGo_CholineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","A","+","choline","=","AH","(","2",")","+","betaine","aldehyde","."),4250663). assertion_content_comment('tOboGo_CholineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","choline","=","ADP","+","choline","phosphate","+","2","H","(","+",")"),4211934). assertion_content_comment('tOboGo_CholineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","choline","(","2-hydroxyethyltrimethylammonium",")",",","an","amino","alcohol","that","occurs","widely","in","living","organisms","as","a","constituent","of","certain","types","of","phospholipids","and","in","the","neurotransmitter","acetylcholine","."),4238985). assertion_content_comment('tOboGo_CholineMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","choline","+","2","reduced","ferredoxin","+","O2","+","2","H","+","=","betaine","aldehyde","hydrate","+","2","oxidized","ferredoxin","+","H2O","."),4237312). assertion_content_comment('tOboGo_Choline_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","choline","(","out",")","+","Na","+","(","out",")","=","choline","(","in",")","+","Na","+","(","in",")"),4216800). assertion_content_comment('tOboGo_CholinesteraseActivity',s("Catalysis","of","the","reaction",":","an","acylcholine","+","H2O","=","choline","+","a","carboxylic","acid","anion","."),4211876). assertion_content_comment('tOboGo_CholineSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phospho-5","'","-adenylyl","sulfate","+","choline","=","adenosine","3","'",",","5","'","-diphosphate","+","choline","sulfate","+","H","(","+",")"),4373197). assertion_content_comment('tOboGo_CholineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","choline","from","one","side","of","the","membrane","to","the","other",".","Choline","(","2-hydroxyethyltrimethylammonium",")","is","an","amino","alcohol","that","occurs","widely","in","living","organisms","as","a","constituent","of","certain","types","of","phospholipids","and","in","the","neurotransmitter","acetylcholine","."),4216795). assertion_content_comment('tOboGo_CholineTransport',s("The","directed","movement","of","choline","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Choline","(","2-hydroxyethyltrimethylammonium",")","is","an","amino","alcohol","that","occurs","widely","in","living","organisms","as","a","constituent","of","certain","types","of","phospholipids","and","in","the","neurotransmitter","acetylcholine","."),4294354). assertion_content_comment('tOboGo_CholoylglycineHydrolaseActivity',s("Catalysis","of","the","reaction",":","3-alpha",",","7-alpha",",","12-alpha-trihydroxy-5-beta-cholan-24-oylglycine","+","H2O","=","3-alpha",",","7-alpha",",","12-alpha-trihydroxy-5-beta-cholanate","+","glycine","."),4298395). assertion_content_comment('tOboGo_ChondroblastDifferentiation',s("The","process","in","which","a","mesenchymal","cell",",","acquires","specialized","structural","and/or","functional","features","of","a","chondroblast",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","chondroblast","fate",".","A","chondroblast","is","a","precursor","cell","to","chondrocytes","."),4116853). assertion_content_comment('tOboGo_ChondrocyteDevelopmentInvolvedInEndochondralBoneMorphogenesis',s("The","progression","of","a","chondrocyte","over","time","from","after","its","commitment","to","its","mature","state","where","the","chondrocyte","will","contribute","to","the","shaping","of","an","endochondral","bone","."),4004157). assertion_content_comment('tOboGo_ChondrocyteDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","chondrocyte","over","time",",","from","its","commitment","to","its","mature","state",".","Chondrocyte","development","does","not","include","the","steps","involved","in","committing","a","chondroblast","to","a","chondrocyte","fate","."),3989931). assertion_content_comment('tOboGo_ChondrocyteDifferentiationInvolvedInEndochondralBoneMorphogenesis',s("The","process","in","which","a","chondroblast","acquires","specialized","structural","and/or","functional","features","of","a","chondrocyte","that","will","contribute","to","the","development","of","a","bone",".","A","chondrocyte","is","a","polymorphic","cell","that","forms","cartilage","."),4004155). assertion_content_comment('tOboGo_ChondrocyteHypertrophy',s("The","growth","of","a","chondrocyte",",","where","growth","contributes","to","the","progression","of","the","chondrocyte","over","time","."),4004253). assertion_content_comment('tOboGo_ChondrocyteIntercalationInvolvedInGrowthPlateCartilageMorphogenesis',s("The","orderly","movement","of","a","chondrocyte","from","one","site","to","another","that","contributes","to","the","shaping","of","growth","plate","cartilage","in","an","endochondral","bone","."),4004343). assertion_content_comment('tOboGo_ChondrocyteMorphogenesisInvolvedInEndochondralBoneMorphogenesis',s("The","process","in","which","the","structures","of","a","chondrocyte","that","will","contribute","to","bone","development","are","generated","and","organized","."),4004226). assertion_content_comment('tOboGo_ChondrocyteMorphogenesis',s("The","process","in","which","the","structures","of","a","chondrocyte","are","generated","and","organized",".","This","process","occurs","while","the","initially","relatively","unspecialized","cell","is","acquiring","the","specialized","features","of","a","chondrocyte","."),4004223). assertion_content_comment('tOboGo_ChondroitinABCLyaseActivity',s("Catalysis","of","the","eliminative","degradation","of","polysaccharides","containing","1",",","4-beta-D-hexosaminyl","and","1",",","3-beta-D-glucuronosyl","or","1",",","3-alpha-L-iduronosyl","linkages","to","disaccharides","containing","4-deoxy-beta-D-gluc-4-enuronosyl","groups","."),4360547). assertion_content_comment('tOboGo_ChondroitinACLyaseActivity',s("Catalysis","of","the","eliminative","degradation","of","polysaccharides","containing","1",",","4-beta-D-hexosaminyl","and","1",",","3-beta-D-glucuronosyl","linkages","to","disaccharides","containing","4-deoxy-beta-D-gluc-4-enuronosyl","groups","."),4309664). assertion_content_comment('tOboGo_ChondroitinBLyaseActivity',s("Catalysis","of","the","eliminative","cleavage","of","dermatan","sulfate","containing","1",",","4-beta-D-hexosaminyl","and","1",",","3-beta-D-glucurosonyl","or","1",",","3-alpha-L-iduronosyl","linkages","to","disaccharides","containing","4-deoxy-beta-D-gluc-4-enuronosyl","groups","to","yield","a","4",",","5-unsaturated","dermatan-sulfate","disaccharide","(","DeltaUA-GalNAC-4S",")"),4345195). assertion_content_comment('tOboGo_ChondroitinSulfateBinding',s("Interacting","selectively","and","non-covalently","with","chondroitin","sulfate",",","a","glycosaminoglycan","made","up","of","two","alternating","monosaccharides",":","D-glucuronic","acid","(","GlcA",")","and","N-acetyl-D-galactosamine","(","GalNAc",")"),4382941). assertion_content_comment('tOboGo_ChondroitinSulfateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","chondroitin","sulfate",",","any","member","of","a","group","of","10-60","kDa","glycosaminoglycans",",","widely","distributed","in","cartilage","and","other","mammalian","connective","tissues",",","the","repeat","units","of","which","consist","of","beta-","(","1",",","4",")","-linked","D-glucuronyl","beta-","(","1",",","3",")","-N-acetyl-D-galactosamine","sulfate","."),4047177). assertion_content_comment('tOboGo_ChondroitinSulfateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","chondroitin","sulfate",",","any","member","of","a","group","of","10-60","kDa","glycosaminoglycans",",","widely","distributed","in","cartilage","and","other","mammalian","connective","tissues",",","the","repeat","units","of","which","consist","of","beta-","(","1",",","4",")","-linked","D-glucuronyl","beta-","(","1",",","3",")","-N-acetyl-D-galactosamine","sulfate","."),4311518). assertion_content_comment('tOboGo_ChondroitinSulfateDermatanSulfateProteoglycan',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217751). assertion_content_comment('tOboGo_ChondroitinSulfateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","chondroitin","sulfate",",","any","member","of","a","group","of","10-60","kDa","glycosaminoglycans",",","widely","distributed","in","cartilage","and","other","mammalian","connective","tissues",",","the","repeat","units","of","which","consist","of","beta-","(","1",",","4",")","-linked","D-glucuronyl","beta-","(","1",",","3",")","-N-acetyl-D-galactosamine","sulfate",".","They","usually","occur","linked","to","a","protein","to","form","proteoglycans",".","Two","subgroups","exist",",","one","in","which","the","sulfate","is","on","the","4-position","(","chondroitin","sulfate","A",")","and","the","second","in","which","it","is","in","the","6-position","(","chondroitin","sulfate","C",")","They","often","are","polydisperse","and","often","differ","in","the","degree","of","sulfation","from","tissue","to","tissue",".","The","chains","of","repeating","disaccharide","are","covalently","linked","to","the","side","chains","of","serine","residues","in","the","polypeptide","backbone","of","a","protein","by","a","glycosidic","attachment","through","the","trisaccharide","unit","galactosyl-galactosyl-xylosyl",".","Chondroitin","sulfate","B","is","more","usually","known","as","dermatan","sulfate","."),4047152). assertion_content_comment('tOboGo_ChondroitinSulfateProteoglycanBinding',s("Interacting","selectively","and","non-covalently","with","a","chondroitin","sulfate","proteoglycan",",","any","proteoglycan","containing","chondroitin","sulfate","as","the","glycosaminoglycan","carbohydrate","unit","."),4382950). assertion_content_comment('tOboGo_ChondroitinSulfateProteoglycanBiosyntheticProcessPolysaccharideChainBiosyntheticProcess',s("The","elongation","of","chondroitin","sulfate","proteoglycan","chains","by","alternate","addition","of","N-acetylhexosamine","and","GlcUA","residues","to","the","GAG-protein","linkage","region","tetrasaccharide","of","chondroitin","sulfate","."),4101816). 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assertion_content_comment('tOboGo_ChromatinDisassembly',s("The","controlled","breakdown","of","chromatin","from","a","higher","order","structure","into","its","simpler","subcomponents",",","DNA",",","histones",",","and","other","proteins","."),4011092). assertion_content_comment('tOboGo_ChromatinDNABinding',s("Interacting","selectively","and","non-covalently","with","DNA","that","is","assembled","into","chromatin","."),4222554). assertion_content_comment('tOboGo_ChromatinInsulatorSequenceBinding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4222559). assertion_content_comment('tOboGo_ChromatinMaintenance',s("The","chromatin","organization","process","that","preserves","chromatin","in","a","stable","functional","or","structural","state","."),4178555). assertion_content_comment('tOboGo_ChromatinModification',s("The","alteration","of","DNA","or","protein","in","chromatin",",","which","may","result","in","changing","the","chromatin","structure","."),3975553). assertion_content_comment('tOboGo_ChromatinOrganization',s("Any","process","that","results","in","the","specification",",","formation","or","maintenance","of","the","physical","structure","of","eukaryotic","chromatin","."),3975550). assertion_content_comment('tOboGo_ChromatinRemodelingAtCentromere',s("Dynamic","structural","changes","in","centromeric","DNA","."),4060816). assertion_content_comment('tOboGo_ChromatinRemodelingComplex',s("Any","complex","that","mediates","dynamic","changes","in","eukaryotic","chromatin","."),3978253). assertion_content_comment('tOboGo_ChromatinRemodelingInResponseToCationStress',s("Structural","changes","to","eukaryotic","chromatin","occurring","as","a","result","of","cation","stress",",","an","increase","or","decrease","in","the","concentration","of","positively","charged","ions","in","the","environment","."),4317611). assertion_content_comment('tOboGo_ChromatinRemodeling',s("Dynamic","structural","changes","to","eukaryotic","chromatin","occurring","throughout","the","cell","division","cycle",".","These","changes","range","from","the","local","changes","necessary","for","transcriptional","regulation","to","global","changes","necessary","for","chromosome","segregation","."),4009313). assertion_content_comment('tOboGo_ChromatinSilencingAtCentromere',s("Repression","of","transcription","of","centromeric","DNA","by","altering","the","structure","of","chromatin","."),4150114). assertion_content_comment('tOboGo_ChromatinSilencingAtRDNA',s("Repression","of","transcription","of","ribosomal","DNA","by","altering","the","structure","of","chromatin","."),4136072). assertion_content_comment('tOboGo_ChromatinSilencingAtTelomere',s("Repression","of","transcription","of","telomeric","DNA","by","altering","the","structure","of","chromatin","."),4057600). assertion_content_comment('tOboGo_ChromatinSilencingBySmallRNA',s("Repression","of","transcription","by","conversion","of","large","regions","of","DNA","into","heterochromatin",",","directed","by","small","RNAs","sharing","sequence","identity","to","the","repressed","region","."),4035002). assertion_content_comment('tOboGo_ChromatinSilencingComplex',s("Any","protein","complex","that","mediates","changes","in","chromatin","structure","that","result","in","transcriptional","silencing","."),4220514). assertion_content_comment('tOboGo_ChromatinSilencing',s("Repression","of","transcription","by","altering","the","structure","of","chromatin",",","e.g",".","by","conversion","of","large","regions","of","DNA","into","an","inaccessible","state","often","called","heterochromatin","."),4009292). assertion_content_comment('tOboGo_Chromatin',s("The","ordered","and","organized","complex","of","DNA","and","protein","that","forms","the","chromosome","."),3978230). assertion_content_comment('tOboGo_ChromatoidBody',s("A","ribonucleoprotein","complex","found","in","the","cytoplasm","of","male","germ","cells",",","composed","of","exceedingly","thin","filaments","that","are","consolidated","into","a","compact","mass","or","into","dense","strands","of","varying","thickness","that","branch","to","form","an","irregular","network",".","Contains","mRNAs",",","miRNAs",",","and","protein","components","involved","in","miRNA","processing","(","such","as","Argonaute","proteins","and","the","endonuclease","Dicer",")","and","in","RNA","decay","(","such","as","the","decapping","enzyme","DCP1a","and","GW182",")"),4338531). assertion_content_comment('tOboGo_ChromatophoreRibuloseBisphosphateCarboxylaseComplex',s("A","complex",",","located","in","the","chromatophore",",","containing","either","both","large","and","small","subunits","or","just","small","subunits","which","carries","out","the","activity","of","producing","3-phosphoglycerate","from","carbon","dioxide","and","ribulose-1",",","5-bisphosphate","."),4103090). assertion_content_comment('tOboGo_ChromiumIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","chromium","(","Cr",")","ions","from","one","side","of","a","membrane","to","the","other","."),4178856). assertion_content_comment('tOboGo_Chromocenter',s("A","region","in","which","centric",",","heterochromatic","portions","of","one","or","more","chromosomes","form","a","compact","structure","."),4007848). 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assertion_content_comment('tOboGo_ChromoplastStroma',s("The","space","enclosed","by","the","double","membrane","of","a","chromoplast","but","excluding","the","photosynthetic","material","."),4022996). assertion_content_comment('tOboGo_ChromoShadowDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","chromo","shadow","domain",",","a","protein","domain","that","is","distantly","related",",","and","found","in","association","with",",","the","chromo","domain","."),4180212). assertion_content_comment('tOboGo_ChromosomalPart',s("Any","constituent","part","of","a","chromosome",",","a","structure","composed","of","a","very","long","molecule","of","DNA","and","associated","proteins","(","e.g",".","histones",")","that","carries","hereditary","information","."),3976677). assertion_content_comment('tOboGo_ChromosomeBreakage',s("Regulated","cleavage","of","the","developing","macronuclear","genome","at","a","limited","number","of","chromosome","breakage","sites","(","CBS",")","The","macronuclear","destined","segment","(","MDS",")","sequence","adjacent","to","the","CBS","(","or","separated","from","it","by","a","BES",")","receives","a","macronuclear","telomere","following","chromosome","breakage","."),4061007). assertion_content_comment('tOboGo_ChromosomeCentromericCoreRegion',s("The","innermost","portion","of","the","centromeric","region","of","a","chromosome",",","encompassing","the","core","region","of","a","chromosome","centromere","and","the","proteins","that","bind","to","it","."),4073562). assertion_content_comment('tOboGo_ChromosomeCentromericOuterRepeatRegion',s("The","portion","of","the","centromeric","region","of","a","chromosome","that","flanks","the","core","region",",","encompassing","repeated","regions","of","a","chromosome","centromere","and","the","proteins","that","bind","to","it","."),4073621). assertion_content_comment('tOboGo_ChromosomeCentromericRegion',s("The","region","of","a","chromosome","that","includes","the","centromeric","DNA","and","associated","proteins",".","In","monocentric","chromosomes",",","this","region","corresponds","to","a","single","area","of","the","chromosome",",","whereas","in","holocentric","chromosomes",",","it","is","evenly","distributed","along","the","chromosome","."),3976691). assertion_content_comment('tOboGo_ChromosomeCondensation',s("The","progressive","compaction","of","dispersed","interphase","chromatin","into","threadlike","chromosomes","prior","to","mitotic","or","meiotic","nuclear","division",",","or","during","apoptosis",",","in","eukaryotic","cells","."),4012741). assertion_content_comment('tOboGo_ChromosomeDecondensation',s("The","alteration","of","chromosome","structure","from","the","condensed","form","to","a","relaxed","disperse","form","."),4012946). assertion_content_comment('tOboGo_ChromosomeLocalization',s("Any","process","in","which","a","chromosome","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4012599). assertion_content_comment('tOboGo_ChromosomeLocalizationToNuclearEnvelopeInvolvedInSynapsis',s("The","directed","movement","of","a","chromosome","to","the","nuclear","envelope","that","contributes","to","synapsis","."),4151445). assertion_content_comment('tOboGo_ChromosomeMovementTowardsSpindlePole',s("The","directed","movement","of","chromosomes","in","the","center","of","the","spindle","towards","the","spindle","poles",",","mediated","by","the","shortening","of","microtubules","attached","to","the","chromosomes","."),4012632). assertion_content_comment('tOboGo_ChromosomeOrganizationInvolvedInMeiosis',s("A","process","of","chromosome","organization","that","is","involved","in","meiosis","."),4011948). assertion_content_comment('tOboGo_ChromosomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","that","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","chromosomes",",","structures","composed","of","a","very","long","molecule","of","DNA","and","associated","proteins","that","carries","hereditary","information","."),3970495). assertion_content_comment('tOboGo_ChromosomePassengerComplexLocalizationToKinetochore',s("A","cellular","protein","complex","localization","that","acts","on","a","chromosome","passenger","complex",";","as","a","result",",","the","complex","is","transported","to",",","or","maintained","in",",","a","specific","location","at","the","kinetochore",".","A","chromosome","passenger","complex","is","a","protein","complex","that","contains","the","BIR-domain-containing","protein","Survivin",",","Aurora","B","kinase",",","INCENP","and","Borealin",",","and","coordinates","various","events","based","on","its","location","to","different","structures","during","the","course","of","mitosis","."),4159050). assertion_content_comment('tOboGo_ChromosomePassengerComplex',s("A","eukaryotically","conserved","protein","complex","that","localizes","to","kinetochores","in","early","mitosis",",","the","spindle","mid-zone","in","anaphase","B","and","to","the","telophase","midbody",".","It","has","been","proposed","that","the","passenger","complex","coordinates","various","events","based","on","its","location","to","different","structures","during","the","course","of","mitosis",".","Complex","members","include","the","BIR-domain-containing","protein","Survivin",",","Aurora","B","kinase",",","INCENP","and","Borealin","."),4329334). assertion_content_comment('tOboGo_Chromosome',s("A","structure","composed","of","a","very","long","molecule","of","DNA","and","associated","proteins","(","e.g",".","histones",")","that","carries","hereditary","information","."),3973101). 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assertion_content_comment('tOboGo_ChronologicalCellAging',s("The","process","associated","with","progression","of","the","cell","from","its","inception","to","the","end","of","its","lifespan","that","occurs","when","the","cell","is","in","a","non-dividing",",","or","quiescent",",","state","."),3979764). assertion_content_comment('tOboGo_ChrysanthemylDiphosphateSynthaseActivity',s("Catalysis","of","the","reaction",":","2","dimethylallyl","diphosphate","=","(","R",",","R",")","-chrysanthemyl","diphosphate","+","diphosphate","."),4343851). assertion_content_comment('tOboGo_ChrysobactinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","siderophore","chrysobactin","(","alpha-N-","(","2",",","3-dihydroxybenzoyl",")","-D-lysyl-L-serine",")"),4315519). assertion_content_comment('tOboGo_ChrysobactinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","siderophore","chrysobactin","(","alpha-N-","(","2",",","3-dihydroxybenzoyl",")","-D-lysyl-L-serine",")"),4315503). assertion_content_comment('tOboGo_ChrysobactinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","siderophore","chrysobactin","(","alpha-N-","(","2",",","3-dihydroxybenzoyl",")","-D-lysyl-L-serine",")"),4315499). assertion_content_comment('tOboGo_ChrysobactinTransporterActivity',s("Enables","the","directed","movement","of","the","siderophore","chrysobactin","(","alpha-N-","(","2",",","3-dihydroxybenzoyl",")","-D-lysyl-L-serine",")","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4315716). assertion_content_comment('tOboGo_ChrysobactinTransport',s("The","directed","movement","of","the","siderophore","chrysobactin","(","alpha-N-","(","2",",","3-dihydroxybenzoyl",")","-D-lysyl-L-serine",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4315706). assertion_content_comment('tOboGo_ChylomicronAssembly',s("The","aggregation","and","arrangement","of","proteins","and","lipids","in","the","intestine","to","form","a","chylomicron","."),4355657). assertion_content_comment('tOboGo_ChylomicronBinding',s("Interacting","selectively","and","non-covalently","with","a","chylomicron",",","a","large","lipoprotein","particle","(","diameter","75-1200","nm",")","composed","of","a","central","core","of","triglycerides","and","cholesterol","surrounded","by","a","protein-phospholipid","coating",".","The","proteins","include","one","molecule","of","apolipoprotein","B-48","and","may","include","a","variety","of","apolipoproteins",",","including","APOAs",",","APOCs","and","APOE","."),4376745). assertion_content_comment('tOboGo_ChylomicronRemnantClearance',s("The","process","in","which","a","chylomicron","remnant","is","removed","from","the","blood","via","receptor-mediated","endocytosis","into","liver","cells","and","its","constituent","parts","degraded","."),4125652). assertion_content_comment('tOboGo_ChylomicronRemnant',s("A","lipoprotein","particle","that","is","derived","from","a","mature","chylomicron","particle","by","the","removal","of","triglycerides","from","the","chylomicron","core","by","lipoprotein","lipase","and","the","subsequent","loss","of","surface","components",".","It","characteristically","contains","apolipoprotein","E","(","APOE",")","and","is","cleared","from","the","blood","by","the","liver","."),4355914). assertion_content_comment('tOboGo_ChylomicronRemodeling',s("The","acquisition",",","loss","or","modification","of","a","protein","or","lipid","within","a","chylomicron",",","including","the","hydrolysis","of","triglyceride","by","lipoprotein","lipase","and","the","subsequent","loss","of","free","fatty","acid","."),4150769). assertion_content_comment('tOboGo_Chylomicron',s("A","large","lipoprotein","particle","(","diameter","75-1200","nm",")","composed","of","a","central","core","of","triglycerides","and","cholesterol","surrounded","by","a","protein-phospholipid","coating",".","The","proteins","include","one","molecule","of","apolipoprotein","B-48","and","may","include","a","variety","of","apolipoproteins",",","including","APOAs",",","APOCs","and","APOE",".","Chylomicrons","are","found","in","blood","or","lymph","and","carry","lipids","from","the","intestines","into","other","body","tissues","."),4316440). assertion_content_comment('tOboGo_ChymaseActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage",":","Phe-Xaa","&","gt",";","Tyr-Xaa","&","gt",";","Trp-Xaa","&","gt",";","Leu-Xaa","."),4311926). assertion_content_comment('tOboGo_ChymosinActivity',s("OBSOLETE",".","Catalysis","of","the","lysis","of","peptide","bonds","with","broad","specificity","similar","to","that","of","pepsin","A",".","Clots","milk","by","cleavage","of","a","single","Ser-Phe-l-Met-Ala","bond","in","kappa-casein","."),4308359). assertion_content_comment('tOboGo_ChymotrypsinActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","of","Tyr-Xaa","&","gt",";","Trp-Xaa","&","gt",";","Phe-Xaa","&","gt",";","Leu-Xaa","."),4209385). assertion_content_comment('tOboGo_ChymotrypsinInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","the","serine","endopeptidase","chymotrypsin","."),4310712). assertion_content_comment('tOboGo_CiliaryBodyMorphogenesis',s("The","process","in","which","the","ciliary","body","generated","and","organized",".","The","ciliary","body","is","the","circumferential","tissue","inside","the","eye","composed","of","the","ciliary","muscle","and","ciliary","processes","."),4113579). assertion_content_comment('tOboGo_CiliaryCellMotility',s("Cell","motility","due","to","the","motion","of","one","or","more","cilia","."),4115698). assertion_content_comment('tOboGo_CiliaryNeurotrophicFactorBinding',s("Interacting","selectively","and","non-covalently","with","the","cytokine","ciliary","neurotrophic","factor","."),4179902). assertion_content_comment('tOboGo_CiliaryNeurotrophicFactorReceptorActivity',s("Combining","with","ciliary","neurotrophic","factor","to","initiate","a","change","in","cell","activity","."),4198805). assertion_content_comment('tOboGo_CiliaryNeurotrophicFactorReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","ciliary","neurotrophic","factor","receptor","."),4214639). assertion_content_comment('tOboGo_CiliaryNeurotrophicFactorReceptorComplex',s("A","protein","complex","that","acts","as","a","receptor","for","the","cytokine","ciliary","neurotrophic","factor","(","CNTF",")","In","humans","the","receptor","complex","is","a","hexamer","composed","of","two","molecules","each","of","CNTF","and","CNTFR","and","one","molecule","each","of","gp130","and","LIFR","."),4133265). assertion_content_comment('tOboGo_CiliaryOrFlagellarMotility',s("Cell","motility","due","to","movement","of","cilia","or","flagella","."),4115695). assertion_content_comment('tOboGo_CiliaryReceptorClusteringInvolvedInSmoothenedSignalingPathway',s("Grouping","of","smoothened","or","patched","receptors","in","a","cilium",",","contributing","to","the","smoothened","signaling","pathway","."),4111266). assertion_content_comment('tOboGo_CiliaryRootlet',s("A","cytoskeleton-like","structure",",","originating","from","the","basal","body","at","the","proximal","end","of","a","cilium",",","and","extending","proximally","toward","the","cell","nucleus",".","Rootlets","are","typically","80-100","nm","in","diameter","and","contain","cross","striae","distributed","at","regular","intervals","of","approximately","55-70","nm","."),4382710). assertion_content_comment('tOboGo_CiliumAssembly',s("The","assembly","of","a","cilium",",","a","specialized","eukaryotic","locomotor","organelle","that","consists","of","a","filiform","extrusion","of","the","cell","surface",".","Each","cilium","is","bounded","by","an","extrusion","of","the","cytoplasmic","membrane",",","and","contains","a","regular","longitudinal","array","of","microtubules",",","anchored","basally","in","a","centriole","."),4073048). assertion_content_comment('tOboGo_CiliumAxonemeAssembly',s("The","assembly","of","a","the","bundle","of","microtubules","and","associated","proteins","that","forms","the","core","of","cilia","in","eukaryotic","cells","and","is","responsible","for","their","movements","."),4073061). assertion_content_comment('tOboGo_CiliumAxoneme',s("The","bundle","of","microtubules","and","associated","proteins","that","forms","the","core","of","cilia","in","eukaryotic","cells","and","is","responsible","for","their","movements","."),4381659). assertion_content_comment('tOboGo_CiliumMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","cilium","."),4159674). assertion_content_comment('tOboGo_CiliumMorphogenesis',s("A","process","that","is","carried","out","at","the","cellular","level","and","in","which","the","structure","of","a","cilium","is","organized","."),4073045). assertion_content_comment('tOboGo_CiliumMovementInvolvedInCellMotility',s("Movement","of","cilia","mediated","by","motor","proteins","that","contributes","to","the","movement","of","a","cell","."),4115708). assertion_content_comment('tOboGo_CiliumMovementInvolvedInDeterminationOfLeftRightAsymmetry',s("The","movement","of","cilia","of","epithelial","cells","resulting","in","the","transport","of","signals","which","determine","asymmetry","in","an","organism","'","s","body","plan","with","respect","to","the","left","and","right","halves","."),4115897). assertion_content_comment('tOboGo_CiliumMovementInvolvedInOtolithFormation',s("The","directed",",","self-propelled","movement","of","a","cilium","of","an","inner","ear","epithelial","cell",",","resulting","the","aggregation","of","otolith","seed","particles","."),4005920). assertion_content_comment('tOboGo_CiliumMovement',s("The","directed",",","self-propelled","movement","of","a","cilium","."),4005815). assertion_content_comment('tOboGo_CiliumPart',s("Any","constituent","part","of","a","cilium",",","a","specialized","eukaryotic","organelle","that","consists","of","a","filiform","extrusion","of","the","cell","surface",".","Each","cilium","is","bounded","by","an","extrusion","of","the","cytoplasmic","membrane",",","and","contains","a","regular","longitudinal","array","of","microtubules",",","anchored","basally","in","a","centriole","."),4077651). assertion_content_comment('tOboGo_Cilium',s("A","specialized","eukaryotic","organelle","that","consists","of","a","filiform","extrusion","of","the","cell","surface",".","Each","cilium","is","bounded","by","an","extrusion","of","the","cytoplasmic","membrane",",","and","contains","a","regular","longitudinal","array","of","microtubules",",","anchored","basally","in","a","centriole","."),4077623). assertion_content_comment('tOboGo_CingulateGyrusDevelopment',s("The","progression","of","the","cingulate","gyrus","over","time","from","its","initial","formation","until","its","mature","state",".","The","cingulate","gyrus","is","a","ridge","in","the","cerebral","cortex","located","dorsal","to","the","corpus","callosum","."),4049332). assertion_content_comment('tOboGo_CinnamateReductaseActivity',s("Catalysis","of","the","reaction",":","3-phenylpropanoate","+","NAD","+","=","(","E",")","-cinnamate","+","NADH","+","H","+"),4327835). assertion_content_comment('tOboGo_CinnamicAcidBiosyntheticProcessInvolvedInCoumarinMetabolism',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cinnamic","acid",",","3-phenyl-2-propenoic","acid",",","which","is","then","utilized","in","the","metabolism","of","coumarin","."),4026457). assertion_content_comment('tOboGo_CinnamicAcidBiosyntheticProcessInvolvedInFlavonoidMetabolism',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cinnamic","acid",",","3-phenyl-2-propenoic","acid",",","which","is","then","utilized","in","the","metabolism","of","flavonoids","."),4026435). assertion_content_comment('tOboGo_CinnamicAcidBiosyntheticProcessInvolvedInSalicylicAcidMetabolism',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cinnamic","acid",",","3-phenyl-2-propenoic","acid",",","which","is","then","utilized","in","the","metabolism","of","salicylic","acid","."),4026534). assertion_content_comment('tOboGo_CinnamicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cinnamic","acid",",","3-phenyl-2-propenoic","acid","."),4026422). assertion_content_comment('tOboGo_CinnamicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cinnamic","acid",",","3-phenyl-2-propenoic","acid","."),4352925). assertion_content_comment('tOboGo_CinnamicAcidEsterBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ester","derivatives","of","cinnamic","acid",",","phenylpropenoic","acid","."),4022336). assertion_content_comment('tOboGo_CinnamicAcidEsterCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ester","derivatives","of","cinnamic","acid",",","phenylpropenoic","acid","."),4352911). assertion_content_comment('tOboGo_CinnamicAcidEsterMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ester","derivatives","of","cinnamic","acid",",","phenylpropenoic","acid","."),4022332). assertion_content_comment('tOboGo_CinnamicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cinnamic","acid",",","3-phenyl-2-propenoic","acid","."),4022291). assertion_content_comment('tOboGo_CinnamicBiosyntheticProcessInvolvedInStilbeneMetabolism',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cinnamic","acid",",","3-phenyl-2-propenoic","acid",",","which","is","then","utilized","in","the","metabolism","of","stilbene","."),4026512). assertion_content_comment('tOboGo_CircadianBehavior',s("The","specific","actions","or","reactions","of","an","organism","that","recur","with","a","regularity","of","approximately","24","hours","."),4015026). assertion_content_comment('tOboGo_CircadianMatingBehavior',s("The","fluctuation","in","mating","behavior","that","occurs","over","an","approximately","24","hour","cycle","."),4380262). assertion_content_comment('tOboGo_CircadianRegulationOfCalciumIonOscillation',s("Any","process","that","modulates","the","concentration","of","cytosolic","free","calcium","ion","[","Ca2","+","]","cyt","with","a","regularity","of","approximately","24","hours","."),4336548). assertion_content_comment('tOboGo_CircadianRegulationOfGeneExpression',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gene","expression","such","that","an","expression","pattern","recurs","with","a","regularity","of","approximately","24","hours","."),4337033). assertion_content_comment('tOboGo_CircadianRegulationOfHeartRateByTheSuprachiasmaticNucleus',s("The","process","in","which","the","suprachiasmatic","nucleus","modulates","heart","rate","at","different","values","with","a","regularity","of","approximately","24","hours","."),4194033). assertion_content_comment('tOboGo_CircadianRegulationOfHeartRate',s("Any","process","in","which","an","organism","modulates","its","heart","rate","at","different","values","with","a","regularity","of","approximately","24","hours","."),4194030). assertion_content_comment('tOboGo_CircadianRegulationOfSystemicArterialBloodPressureByHormone',s("The","process","in","which","hormones","modulate","the","force","with","which","blood","passes","through","the","circulatory","system","contributing","to","different","values","of","blood","pressure","oscillating","with","a","regularity","of","approximately","24","hours",".","A","hormone","is","one","of","a","group","of","substances","formed","in","very","small","amounts","in","one","specialized","organ","or","group","of","cells","and","carried","(","sometimes","in","the","bloodstream",")","to","another","organ","or","group","of","cells",",","in","the","same","organism",",","upon","which","they","have","a","specific","regulatory","action","."),4003928). assertion_content_comment('tOboGo_CircadianRegulationOfSystemicArterialBloodPressureByTheSuprachiasmaticNucleus',s("The","process","in","which","the","suprachiasmatic","nucleus","modulates","blood","pressure","at","different","values","with","a","regularity","of","approximately","24","hours","."),4194046). assertion_content_comment('tOboGo_CircadianRegulationOfSystemicArterialBloodPressure',s("Any","process","in","which","an","organism","modulates","its","blood","pressure","at","different","values","with","a","regularity","of","approximately","24","hours","."),4003918). assertion_content_comment('tOboGo_CircadianRhythm',s("Any","biological","process","in","an","organism","that","recurs","with","a","regularity","of","approximately","24","hours","."),4003913). assertion_content_comment('tOboGo_CircadianSleepWakeCycleProcess',s("A","behavioral","process","involved","in","the","cycle","from","wakefulness","through","an","orderly","succession","of","sleep","states","and","stages","that","occurs","on","an","approximately","24","hour","rhythm","."),4036765). assertion_content_comment('tOboGo_CircadianSleepWakeCycleREMSleep',s("A","stage","in","the","circadian","sleep","cycle","during","which","dreams","occur","and","the","body","undergoes","marked","changes","including","rapid","eye","movement",",","loss","of","reflexes",",","and","increased","pulse","rate","and","brain","activity","."),4077273). assertion_content_comment('tOboGo_CircadianSleepWakeCycleSleep',s("The","part","of","the","circadian","sleep/wake","cycle","where","the","organism","is","asleep","."),4077263). assertion_content_comment('tOboGo_CircadianSleepWakeCycle',s("The","cycle","from","wakefulness","through","an","orderly","succession","of","sleep","states","and","stages","that","occurs","on","an","approximately","24","hour","rhythm","."),4036763). assertion_content_comment('tOboGo_CircadianSleepWakeCycleWakefulness',s("The","part","of","the","circadian","sleep/wake","cycle","where","the","organism","is","not","asleep","."),4036767). assertion_content_comment('tOboGo_CircadianTemperatureHomeostasis',s("Any","homeostatic","process","in","which","an","organism","modulates","its","internal","body","temperature","at","different","values","with","a","regularity","of","approximately","24","hours","."),4159453). assertion_content_comment('tOboGo_CirculatorySystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","circulatory","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","circulatory","system","is","the","organ","system","that","passes","nutrients","(","such","as","amino","acids","and","electrolytes",")",",","gases",",","hormones",",","blood","cells",",","etc",".","to","and","from","cells","in","the","body","to","help","fight","diseases","and","help","stabilize","body","temperature","and","pH","to","maintain","homeostasis","."),3980666). assertion_content_comment('tOboGo_CirculatorySystemProcess',s("A","organ","system","process","carried","out","by","any","of","the","organs","or","tissues","of","the","circulatory","system",".","The","circulatory","system","is","an","organ","system","that","moves","extracellular","fluids","to","and","from","tissue","within","a","multicellular","organism","."),3987257). assertion_content_comment('tOboGo_CircumferentialGrowthInvolvedInLeftVentricleMorphogenesis',s("The","morphogenetic","growth","in","which","the","left","ventricle","grows","expanding","its","external","boundary","."),4002755). assertion_content_comment('tOboGo_Circumnutation',s("The","organismal","movement","by","which","the","tip","of","a","plant","organ","follows","a","spiral","pattern","as","a","consequence","of","growth","."),4330103). assertion_content_comment('tOboGo_CisternalProgression',s("The","process","that","results","in","the","physical","movement","of","a","new","cis-Golgi","stack","from","the","cis-position",",","nearest","the","endoplasmic","reticulum","(","ER",")",",","to","the","trans","position",",","farthest","from","the","ER",",","successively","becoming","first","a","medial-Golgi","cisterna","and","then","a","trans-Golgi","cisterna","."),4301035). assertion_content_comment('tOboGo_CitramalateLyaseActivity',s("Catalysis","of","the","reaction",":","S-citramalate","=","acetate","+","pyruvate","."),4374010). assertion_content_comment('tOboGo_CitrateCatabolicProcessToDiacetyl',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","citrate","to","diacetyl",",","yielding","energy","in","the","form","of","ATP","."),4244345). assertion_content_comment('tOboGo_CitrateDehydrataseActivity',s("Catalysis","of","the","reaction",":","citrate","=","cis-aconitate","+","H2O","."),4373985). assertion_content_comment('tOboGo_Citrate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","citrate","(","out",")","+","H","+","(","out",")","=","citrate","(","in",")","+","H","+","(","in",")"),4293173). assertion_content_comment('tOboGo_CitrateLyaseComplex',s("Citrate","lyase","is","a","multienzyme","complex","with","three","constituents",":","the","alpha","subunit",",","citrate-ACP","transferase",";","the","beta","subunit",",","citryl-ACP","lyase",";","and","the","gamma","subunit",",","an","acyl-carrier","protein","which","also","carries","the","prosthetic","group","components",".","All","three","subunits","are","required","for","citrate","lyase","enzyme","activity","."),4259592). assertion_content_comment('tOboGo_CitrateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","citrate",",","2-hydroxy-1",",","2",",","3-propanetricarboyxlate",".","Citrate","is","widely","distributed","in","nature","and","is","an","important","intermediate","in","the","TCA","cycle","and","the","glyoxylate","cycle","."),4224448). assertion_content_comment('tOboGo_CitrateSecondaryActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","citrate","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4168272). assertion_content_comment('tOboGo_Citrate_SuccinateAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","citrate","(","out",")","+","succinate","(","in",")","=","citrate","(","in",")","+","succinate","(","out",")"),4292774). assertion_content_comment('tOboGo_CitrateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","citrate",",","2-hydroxy-1",",","2",",","3-propanetricarboyxlate",",","from","one","side","of","the","membrane","to","the","other","."),4168270). assertion_content_comment('tOboGo_CitrateTransport',s("The","directed","movement","of","citrate",",","2-hydroxy-1",",","2",",","3-propanetricarboyxlate",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4228534). assertion_content_comment('tOboGo_CitrazinateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","citrazinate","+","H2O","=","2",",","3",",","6-trihydroxyisonicotinate","+","2","H","+","+","2","e-","."),4351075). assertion_content_comment('tOboGo_CitrazinateHydrolaseActivity',s("Catalysis","of","the","reaction",":","citrazinate","+","H2O","=","cis-aconitamide","."),4351084). assertion_content_comment('tOboGo_CitricAcidSecretion',s("The","controlled","release","of","citric","acid",",","2-hydroxy-1",",","2",",","3-propanetricarboxylic","acid",",","by","a","cell","or","group","of","cells","."),4356895). assertion_content_comment('tOboGo_CitronellalDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","citronellal","+","NAD","+","+","OH-","=","citronellate","+","NADH","+","H","+"),4350565). assertion_content_comment('tOboGo_CitronellolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","citronellol","+","NAD","+","=","citronellal","+","NADH","+","H","+"),4350511). assertion_content_comment('tOboGo_CitrullinaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","citrulline","=","NH3","+","CO2","+","L-ornithine","."),4373972). assertion_content_comment('tOboGo_CitrullineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","citrulline",",","N5-carbamoyl-L-ornithine",",","an","alpha","amino","acid","not","found","in","proteins","."),4238577). assertion_content_comment('tOboGo_CitrullineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","citrulline",",","N5-carbamoyl-L-ornithine",",","an","alpha","amino","acid","not","found","in","proteins","."),4238563). assertion_content_comment('tOboGo_CitrullineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","citrulline",",","N5-carbamoyl-L-ornithine",",","an","alpha","amino","acid","not","found","in","proteins","."),4238558). assertion_content_comment('tOboGo_ClaraCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","Clara","cell",".","A","Clara","cell","is","an","unciliated","epithelial","cell","found","in","the","respiratory","and","terminal","bronchioles","."),4160634). assertion_content_comment('tOboGo_ClassicalArabinogalactanProteinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","cell","wall","arabinogalactan","II","glycoprotein",",","which","is","composed","of","a","group","of","core","protein","containing","Hyp",",","Ala",",","Ser",",","Thr","and","Gly","as","the","major","amino","acid","constituents",",","and","the","C-terminus","is","GPI","anchored","."),4333001). assertion_content_comment('tOboGo_ClassICytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4258972). assertion_content_comment('tOboGo_ClassIIaCytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259361). assertion_content_comment('tOboGo_ClassIIbCytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259273). assertion_content_comment('tOboGo_ClassIICytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4258983). assertion_content_comment('tOboGo_ClassIIICytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259383). assertion_content_comment('tOboGo_ClassIIMajorHistocompatibilityComplexAntigen',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4187974). assertion_content_comment('tOboGo_ClassIMajorHistocompatibilityComplexAntigen',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4187995). assertion_content_comment('tOboGo_ClassIVCytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259317). assertion_content_comment('tOboGo_ClathrinAdaptorActivity',s("The","binding","activity","of","a","molecule","that","brings","together","clathrin","and","one","or","more","other","molecules",",","permitting","them","to","function","in","a","coordinated","way","."),4379623). assertion_content_comment('tOboGo_ClathrinAdaptorComplex',s("A","membrane","coat","adaptor","complex","that","links","clathrin","to","a","membrane","."),4053067). assertion_content_comment('tOboGo_ClathrinAdaptor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220582). assertion_content_comment('tOboGo_ClathrinBinding',s("Interacting","selectively","and","non-covalently","with","a","clathrin","heavy","or","light","chain",",","the","main","components","of","the","coat","of","coated","vesicles","and","coated","pits",",","and","which","also","occurs","in","synaptic","vesicles","."),4311986). assertion_content_comment('tOboGo_ClathrinCoatAssembly',s("The","process","that","results","in","the","assembly","of","clathrin","triskelia","into","the","ordered","structure","known","as","a","clathrin","cage","."),4025353). assertion_content_comment('tOboGo_ClathrinCoatDisassembly',s("The","disaggregation","of","a","clathrin","coat","into","its","constituent","components",";","results","in","stripping","or","removing","the","clathrin","coat","from","clathrin","coated","vesicles","(","CCV",")","before","fusing","with","their","targets",".","CVVs","transport","cargo","from","plasma","membrane","and","trans-Golgi","to","the","endosomal","system","."),4158650). assertion_content_comment('tOboGo_ClathrinCoatedVesicleMembrane',s("The","lipid","bilayer","surrounding","a","clathrin-coated","vesicle","."),4036155). assertion_content_comment('tOboGo_ClathrinCoatingOfGolgiVesiclePlasmaMembraneToEndosomeTargeting',s("The","addition","of","clathrin","and","adaptor","proteins","to","Golgi","membranes","during","the","formation","of","transport","vesicles","that","will","move","from","the","plasma","membrane","to","the","endosome",",","forming","a","vesicle","coat","."),4025380). assertion_content_comment('tOboGo_ClathrinCoatingOfGolgiVesicle',s("The","addition","of","clathrin","and","adaptor","proteins","to","Golgi","membranes","during","the","formation","of","transport","vesicles",",","forming","a","vesicle","coat","."),4025356). assertion_content_comment('tOboGo_ClathrinCoatOfCoatedPit',s("The","coat","found","on","coated","pits","and","the","coated","vesicles","derived","from","coated","pits",";","comprises","clathrin","and","the","AP-2","adaptor","complex","."),4053078). assertion_content_comment('tOboGo_ClathrinCoatOfEndocyticVesicle',s("A","clathrin","coat","found","on","an","endocytic","vesicle","."),4053109). assertion_content_comment('tOboGo_ClathrinCoatOfSynapticVesicle',s("A","clathrin","coat","found","on","a","synaptic","vesicle","."),4053121). assertion_content_comment('tOboGo_ClathrinCoat',s("A","membrane","coat","found","on","coated","pits","and","some","coated","vesicles",";","consists","of","polymerized","clathrin","triskelions",",","each","comprising","three","clathrin","heavy","chains","and","three","clathrin","light","chains",",","linked","to","the","membrane","via","one","of","the","AP","adaptor","complexes","."),4053056). assertion_content_comment('tOboGo_ClathrinComplex',s("A","protein","complex","that","consists","of","three","clathrin","heavy","chains","and","three","clathrin","light","chains",",","organized","into","a","symmetrical","three-legged","structure","called","a","triskelion",".","In","clathrin-coated","vesicles","clathrin","is","the","main","component","of","the","coat","and","forms","a","polymeric","mechanical","scaffold","on","the","vesicle","surface","."),4128533). assertion_content_comment('tOboGo_ClathrinHeavyChainBinding',s("Interacting","selectively","and","non-covalently","with","a","clathrin","heavy","chain","."),4330324). assertion_content_comment('tOboGo_ClathrinLightChainBinding',s("Interacting","selectively","and","non-covalently","with","a","clathrin","light","chain","."),4330315). assertion_content_comment('tOboGo_ClathrinSculptedAcetylcholineTransportVesicleLumen',s("The","volume","enclosed","by","the","membrane","of","the","clathrin","sculpted","acetylcholine","transport","vesicle","."),4115667). assertion_content_comment('tOboGo_ClathrinSculptedAcetylcholineTransportVesicleMembrane',s("The","lipid","bilayer","surrounding","a","clathrin","sculpted","acetylcholine","transport","vesicle","."),4115678). assertion_content_comment('tOboGo_ClathrinSculptedAcetylcholineTransportVesicle',s("A","clathrin","sculpted","lipid","bilayer","membrane-enclosed","vesicle","after","clathrin","release","and","containing","acetylcholine","."),4115657). assertion_content_comment('tOboGo_ClathrinSculptedGlutamateTransportVesicleLumen',s("The","volume","enclosed","by","the","membrane","of","the","clathrin","sculpted","glutamate","transport","vesicle","."),4115636). assertion_content_comment('tOboGo_ClathrinSculptedGlutamateTransportVesicleMembrane',s("The","lipid","bilayer","surrounding","a","clathrin","sculpted","glutamate","transport","vesicle","."),4115647). assertion_content_comment('tOboGo_ClathrinSculptedGlutamateTransportVesicle',s("A","clathrin","sculpted","lipid","bilayer","membrane-enclosed","vesicle","after","clathrin","release","and","containing","glutamate","."),4115626). assertion_content_comment('tOboGo_ClathrinSculptedMonoamineTransportVesicleLumen',s("The","volume","enclosed","by","the","membrane","of","the","clathrin","sculpted","monoamine","transport","vesicle","."),4133869). assertion_content_comment('tOboGo_ClathrinSculptedMonoamineTransportVesicleMembrane',s("The","lipid","bilayer","surrounding","a","clathrin","sculpted","monoamine","transport","vesicle","."),4133859). assertion_content_comment('tOboGo_ClathrinSculptedMonoamineTransportVesicle',s("A","clathrin","sculpted","lipid","bilayer","membrane-enclosed","vesicle","after","clathrin","release","and","containing","monoamines","."),4133848). assertion_content_comment('tOboGo_ClathrinSculptedVesicle',s("A","clathrin","sculpted","lipid","bilayer","membrane-enclosed","vesicle","after","clathrin","release","."),4115624). assertion_content_comment('tOboGo_ClathrinVesicleCoat',s("A","clathrin","coat","found","on","a","vesicle","."),4053106). assertion_content_comment('tOboGo_ClavaminateSynthaseActivity',s("Catalysis","of","the","reactions",":","deoxyamidinoproclavaminate","+","2-oxoglutarate","+","O2","=","amidinoproclavaminate","+","succinate","+","CO2","+","H2O",";","proclavaminate","+","2-oxoglutarate","+","O2","=","dihydroclavaminate","+","succinate","+","CO2","+","2","H2O",";","and","dihydroclavaminate","+","2-oxoglutarate","+","O2","=","clavaminate","+","succinate","+","CO2","+","2","H2O","."),4342666). assertion_content_comment('tOboGo_ClavulanicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","clavulanic","acid",",","(","2R",",","3Z",",","5R",")","-3-","(","2-hydroxyethylidene",")","-7-oxo-4-oxa-1-azabicyclo","[","3.2.0","]","heptane-2-carboxylic","acid","."),4347260). assertion_content_comment('tOboGo_ClavulanicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","clavulanic","acid",",","(","2R",",","3Z",",","5R",")","-3-","(","2-hydroxyethylidene",")","-7-oxo-4-oxa-1-azabicyclo","[","3.2.0","]","heptane-2-carboxylic","acid","."),4347256). assertion_content_comment('tOboGo_ClearanceOfCellsFromFusionPlateByApoptosis',s("The","process","of","apoptosis","that","contributes","to","the","shaping","of","the","semicircular","canal","by","removing","cells","in","the","fusion","plate",",","forming","the","loops","of","the","canals","."),4156394). assertion_content_comment('tOboGo_ClearanceOfCellsFromFusionPlateByEpithelialToMesenchymalTransition',s("The","process","of","epithelial","to","mesenchymal","transition","that","contributes","to","the","shaping","of","the","semicircular","canal","by","effectively","removing","epithelial","cells","from","the","fusion","plate",",","forming","the","loops","of","the","canals","."),4156404). assertion_content_comment('tOboGo_ClearanceOfCellsFromFusionPlate',s("The","morphogenetic","process","in","which","cells","are","removed","from","the","inner","loop","of","a","semicircular","canal","."),4114049). assertion_content_comment('tOboGo_ClearanceOfDamagedTissueInvolvedInInflammatoryResponseWoundHealing',s("The","series","of","events","leading","to","removal","of","necrotic","debris","that","contribute","to","an","inflammatory","response","."),3992208). assertion_content_comment('tOboGo_CleavageAndPolyadenylylationSpecificityFactorActivity',s("OBSOLETE",".","A","factor","required","in","mRNA","3","'","end","processing","for","both","the","cleavage","and","poly","(","A",")","addition","reactions","and",",","consistent","with","this","function",",","recognizes","AAUAAA",",","a","signal","also","essential","for","both","reactions","."),4309860). assertion_content_comment('tOboGo_CleavageApparatusSeptinStructure',s("Any","of","a","series","of","structures","composed","of","septins","and","septin-associated","proteins","localized","to","the","cleavage","plane","which","are","involved","in","cytokinesis","."),4054870). assertion_content_comment('tOboGo_CleavageBody',s("A","nuclear","body","that","contains","proteins","involved","in","pre-mRNA","3","'","-end","cleavage","and","polyadenylation",",","such","as","DDX1",",","CSTF2","and","CPSFs",",","as","well","as","the","transcription","factors","TFIIE","and","TFIIF",".","Cleavage","bodies","are","localized","adjacent","to","Cajal","bodies","and","are","involved","in","mRNA3","'","-end","processing","."),4167912). assertion_content_comment('tOboGo_CleavageFurrow',s("In","animal","cells",",","the","first","sign","of","cleavage",",","or","cytokinesis",",","is","the","appearance","of","a","shallow","groove","in","the","cell","surface","near","the","old","metaphase","plate",".","A","contractile","ring","containing","actin","and","myosin","is","located","just","inside","the","plasma","membrane","at","the","location","of","the","furrow",".","Ring","contraction","is","associated","with","centripetal","growth","of","the","membrane","that","deepens","the","cleavage","furrow","and","divides","the","cytoplasm","of","the","two","daughter","cells",".","While","the","term","'","cleavage","furrow","'","was","initially","associated","with","animal","cells",",","such","a","structure","occurs","in","many","other","types","of","cells",",","including","unicellular","protists","."),4329175). assertion_content_comment('tOboGo_CleavageInvolvedInRRNAProcessing',s("Any","cleavage","involved","in","the","conversion","of","a","primary","ribosomal","RNA","(","rRNA",")","transcript","into","a","mature","rRNA","molecule","."),3976062). assertion_content_comment('tOboGo_CleavageOfCytoskeletalProteinsInvolvedInApoptosis',s("The","proteolytic","degradation","of","cytoskeletal","proteins","that","contributes","to","apoptosis",",","leading","to","the","collapse","of","cytoskeletal","structures","."),4011476). assertion_content_comment('tOboGo_CleavageOfCytosolicProteinsInvolvedInApoptosis',s("The","proteolytic","degradation","of","proteins","in","the","cytosol","that","contributes","to","apoptosis","."),4061074). assertion_content_comment('tOboGo_CleavageOfLamin',s("The","proteolytic","degradation","of","lamins","during","apoptosis",",","leading","to","the","irreversible","breakdown","of","the","nuclear","lamina","."),4232385). assertion_content_comment('tOboGo_CleavageStimulationFactorActivity',s("OBSOLETE",".","A","factor","is","necessary","for","cleavage","but","not","for","poly","(","A",")","addition","in","mRNA","3","'","end","processing",";","can","stimulate","poly","(","A",")","addition","on","substrates","with","a","CstF","binding","site","upstream","of","the","AAUAAA","hexanucleotide","."),4309846). assertion_content_comment('tOboGo_CleistotheciumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","cleistothecium","over","time",",","from","its","formation","to","the","mature","structure",".","The","cleistothecium","is","a","closed","sexual","fruiting","body","that","contains","ascospores","in","linear","asci",",","characteristic","of","some","filamentous","Ascomycete","fungi","such","as","members","of","the","genera","Aspergillus","and","Emericella","."),4132442). assertion_content_comment('tOboGo_ClimbingFiber',s("The","axon","of","inferior","olive","neuron","that","projects","to","the","cerebellar","cortex",",","largely","via","the","inferior","cerebellar","peduncle",".","They","range","in","diameter","from","1-3","um","and","are","myelinated","until","they","enter","the","granule","cell","layer",".","They","give","off","collaterals","to","the","deep","cerebellar","nuclei",".","They","synapse","extensively","with","the","dendrites","of","Purkinje","cells","in","the","molecular","layer",",","where","each","fiber","branches","repeatedly","to","\"","climb","\"","along","the","Purkinje","cell","dendritic","tree",".","Each","Purkinje","cell","is","innervated","by","only","a","single","climbing","fiber","."),4287871). assertion_content_comment('tOboGo_CloacalSeptation',s("The","separation","of","the","single","opening","of","the","digestive",",","urinary",",","and","reproductive","tracts",",","the","cloaca",",","into","multiple","isolated","openings","during","development","."),4115585). assertion_content_comment('tOboGo_ClostripainActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","Arg-Xaa","bonds","."),4286889). assertion_content_comment('tOboGo_ClosureOfEmbryonicHeartTube',s("Creation","of","the","central","hole","of","the","embryonic","heart","tube","by","sealing","the","edges","of","an","epithelial","fold","."),4003607). assertion_content_comment('tOboGo_ClosureOfOpticFissure',s("The","closure","of","the","temporary","ventral","gap","in","the","optic","cup","that","contributes","to","its","shaping","."),4133461). assertion_content_comment('tOboGo_CLRCUbiquitinLigaseComplex',s("An","active","cullin-dependent","E3","ubiquitin","ligase","complex","essential","for","heterochromatin","assembly","by","RNAi","and","histone","H3K9","methylation","."),4325083). assertion_content_comment('tOboGo_ClypeusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","clypeus","over","time",",","from","its","formation","to","the","mature","structure",".","The","clypeus","is","the","shield-shaped","plate","on","an","insect","'","s","head","."),4107334). assertion_content_comment('tOboGo_ClypeusMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","clypeus","are","generated","and","organized","."),4107345). assertion_content_comment('tOboGo_CMGComplex',s("A","protein","complex","that","contains","the","GINS","complex",",","Cdc45p",",","and","the","heterohexameric","MCM","complex",",","and","that","is","involved","in","unwinding","DNA","during","replication","."),4164752). assertion_content_comment('tOboGo_CMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","CMP",",","cytidine","monophosphate","."),4225887). assertion_content_comment('tOboGo_CMPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","CMP",",","cytidine","monophosphate","."),4223521). assertion_content_comment('tOboGo_CMPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","CMP",",","cytidine","monophosphate","."),4223518). assertion_content_comment('tOboGo_CMPSalvage',s("Any","process","that","generates","CMP",",","cytidine","monophosphate",",","from","derivatives","of","it","without","de","novo","synthesis","."),4225905). assertion_content_comment('tOboGo_CoACarboxylaseActivity',s("Catalysis","of","the","joining","of","a","carboxyl","group","to","a","molecule","that","is","attached","to","CoA",",","with","the","concomitant","hydrolysis","of","the","diphosphate","bond","in","ATP","or","a","similar","triphosphate","."),4186567). assertion_content_comment('tOboGo_CoADesaturaseActivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","reduced","acceptor","+","O2","=","desaturated-acyl-CoA","+","acceptor","+","2","H2O","."),4201583). assertion_content_comment('tOboGo_CoagulationFactorIXaActivity',s("OBSOLETE",".","Catalysis","of","the","selective","cleavage","of","the","Arg-Ile","bond","in","factor","X","to","form","factor","Xa","."),4187885). assertion_content_comment('tOboGo_CoagulationFactorVIIaActivity',s("OBSOLETE",".","Catalysis","of","the","selective","cleavage","of","one","Arg-Ile","bond","in","factor","X","to","form","factor","Xa",",","and","on","factor","IX","to","form","factor","IXa","beta","."),4187871). assertion_content_comment('tOboGo_CoagulationFactorXaActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","of","Arg-Thr","and","then","Arg-Ile","bonds","in","prothrombin","to","form","thrombin",",","and","on","factor","VII",",","which","it","converts","to","a","two-chain","form","(","factor","VIIa",")"),4187904). assertion_content_comment('tOboGo_CoagulationFactorXIaActivity',s("OBSOLETE",".","Catalysis","of","the","selective","cleavage","of","Arg-Ala","and","Arg-Val","bonds","in","factor","IX","to","form","factor","IXa","."),4187928). assertion_content_comment('tOboGo_CoagulationFactorXIIaActivity',s("OBSOLETE",".","Catalysis","of","the","selective","cleavage","of","Arg-Ile","bonds","in","factor","VII","to","form","factor","VIIa","and","factor","XI","to","form","factor","XIa","."),4187779). assertion_content_comment('tOboGo_Coagulation',s("The","process","in","which","a","fluid","solution",",","or","part","of","it",",","changes","into","a","solid","or","semisolid","mass","."),3996524). assertion_content_comment('tOboGo_CoAHydrolaseActivity',s("Catalysis","of","the","reaction",":","X-CoA","+","H2O","=","X","+","CoA",";","X","may","be","any","group","."),4187178). assertion_content_comment('tOboGo_CoAPyrophosphataseActivity',s("Catalysis","of","the","reaction",":","coenzyme","A","+","H2O","=","3","'",",","5","'","-ADP","+","4","'","-phosphopantetheine","."),4336090). assertion_content_comment('tOboGo_CoatedMembrane',s("A","single","or","double","lipid","bilayer","with","any","of","several","different","proteinaceous","coats","that","can","associate","with","membranes",".","Membrane","coats","include","those","formed","by","clathrin","plus","an","adaptor","complex",",","the","COPI","and","COPII","complexes","."),4053026). assertion_content_comment('tOboGo_CoatedPit',s("A","part","of","the","endomembrane","system","in","the","form","of","an","invagination","of","a","membrane","upon","which","a","clathrin","coat","forms",",","and","that","can","be","converted","by","vesicle","budding","into","a","clathrin-coated","vesicle",".","Coated","pits","form","on","the","plasma","membrane",",","where","they","are","involved","in","receptor-mediated","selective","transport","of","many","proteins","and","other","macromolecules","across","the","cell","membrane",",","in","the","trans-Golgi","network",",","and","on","some","endosomes","."),4008267). 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assertion_content_comment('tOboGo_CollagenTypeII',s("A","collagen","homotrimer","of","alpha1","(","II",")","chains",";","type","II","collagen","triple","helices","associate","to","form","fibrils","."),4218494). assertion_content_comment('tOboGo_CollagenTypeI',s("A","collagen","trimer","containing","alpha","(","I",")","chains",".","The","most","common","form","of","type","I","collagen","is","a","heterotrimer","containing","two","alpha1","(","I",")","chains","and","one","alpha2","(","I",")","chain",";","homotrimers","containing","three","alpha1","(","I",")","chains","are","also","found",".","Type","I","collagen","triple","helices","associate","to","form","banded","fibrils","."),4218476). assertion_content_comment('tOboGo_CollagenTypeIV',s("A","collagen","heterotrimer","containing","type","IV","alpha","chains",";","[","alpha1","(","IV",")","]","2alpha2","(","IV",")","trimers","are","commonly","observed",",","although","more","type","IV","alpha","chains","exist","and","may","be","present","in","type","IV","trimers",";","type","IV","collagen","triple","helices","associate","to","form","nets","within","basement","membranes","."),4007150). assertion_content_comment('tOboGo_CollagenTypeIX',s("A","collagen","heterotrimer","containing","type","IX","alpha","chains","in","alpha1","(","IX",")","alpha2","(","IX",")","alpha3","(","IX",")","trimers",";","type","IX","collagen","triple","helices","associate","to","form","a","structure","that","links","glycosaminoglycans","to","type","II","collagen","fibrils","."),4218159). assertion_content_comment('tOboGo_CollagenTypeVIII',s("A","collagen","heterotrimer","containing","type","VIII","alpha","chains",";","[","alpha1","(","VIII",")","2","]","alpha2","(","VIII",")","and","alpha1","(","VIII",")","[","alpha2","(","VIII",")","]","2","trimers","have","been","observed",";","type","VIII","collagen","triple","helices","associate","to","form","regular","hexagonal","nets","."),4218132). assertion_content_comment('tOboGo_CollagenTypeVII',s("A","collagen","homotrimer","of","alpha1","(","VII",")","chains",";","type","VII","collagen","triple","helices","form","antiparallel","dimer",",","which","in","turn","associate","laterally","to","form","anchoring","fibrils","that","connect","type","IV","collagen","in","the","basal","lamina","to","plaques","in","the","underlying","connective","tissue","."),4218123). assertion_content_comment('tOboGo_CollagenTypeVI',s("A","collagen","heterotrimer","containing","type","VI","alpha","chains","in","alpha1","(","VI",")","alpha2","(","VI",")","alpha3","(","VI",")","trimers",";","type","VI","collagen","triple","helices","associate","to","form","beaded","fibrils","."),4218532). assertion_content_comment('tOboGo_CollagenTypeV',s("A","collagen","heterotrimer","containing","type","V","alpha","chains",";","[","alpha1","(","V",")","]","2alpha2","(","V",")","and","alpha1","(","V",")","alpha2","(","V",")","alpha3","(","V",")","trimers","have","been","observed",";","type","V","collagen","triple","helices","associate","to","form","fibrils","."),4218523). assertion_content_comment('tOboGo_CollagenTypeXIII',s("A","collagen","homotrimer","of","alpha1","(","XIII",")","chains",";","type","X","collagen","triple","helices","span","lipid","bilayer","membranes","."),4220103). assertion_content_comment('tOboGo_CollagenTypeXII',s("A","collagen","homotrimer","of","alpha1","(","XII",")","chains",";","type","XII","collagen","triple","helices","may","link","sheet-forming","or","fibrillar","collagens","to","other","structures","."),4218168). assertion_content_comment('tOboGo_CollagenTypeXI',s("A","collagen","heterotrimer","containing","type","XI","alpha","chains","in","alpha1","(","XI",")","alpha2","(","XI",")","alpha3","(","XI",")","trimers",";","type","XI","collagen","triple","helices","associate","to","form","fibrils","."),4218094). assertion_content_comment('tOboGo_CollagenTypeXIV',s("A","collagen","homotrimer","of","alpha1","(","XIV",")","chains",";","type","XIV","collagen","triple","helices","may","link","sheet-forming","or","fibrillar","collagens","to","other","structures","."),4218141). assertion_content_comment('tOboGo_CollagenTypeX',s("A","collagen","homotrimer","of","alpha1","(","X",")","chains",";","type","X","collagen","triple","helices","may","form","nets","."),4218076). assertion_content_comment('tOboGo_CollagenTypeXVIII',s("A","collagen","homotrimer","of","alpha1","(","XVIII",")","chains","."),4307531). assertion_content_comment('tOboGo_CollagenTypeXVII',s("A","collagen","homotrimer","of","alpha1","(","XVII",")","chains",";","type","XVII","collagen","triple","helices","associate","with","hemidesmosomes","and","the","basal","lamina","."),4307551). assertion_content_comment('tOboGo_CollagenTypeXVI',s("A","collagen","trimer","containing","alpha","(","XVI",")","chains",";","type","XVI","trimers","can","associate","with","microfibrils","."),4218150). assertion_content_comment('tOboGo_CollagenTypeXV',s("A","collagen","homotrimer","of","alpha1","(","XV",")","chains",";","a","chondroitin","sulfate","proteoglycan","often","found","in","specialized","basement","membranes","."),4218514). assertion_content_comment('tOboGo_CollagenVBinding',s("Interacting","selectively","and","non-covalently","with","a","type","V","collagen","."),4180671). assertion_content_comment('tOboGo_CollateralSproutingInAbsenceOfInjury',s("The","process","in","which","outgrowths","develop","from","the","axons","of","intact","undamaged","neurons","."),4107015). assertion_content_comment('tOboGo_CollateralSproutingOfInjuredAxon',s("The","process","resulting","in","reformation","of","a","growth","cone","by","the","tip","of","an","injured","axon",",","or","in","collateral","sprouting","of","the","axon",".","Collateral","sprouting","is","the","process","in","which","outgrowths","develop","from","the","shafts","of","existing","axons","."),4106962). assertion_content_comment('tOboGo_CollateralSproutingOfIntactAxonInResponseToInjury',s("The","process","in","which","outgrowths","develop","from","the","axons","of","intact","undamaged","neurons","as","a","result","of","injury","to","an","axon",".","The","collateral","sprouts","typically","appear","from","undamaged","axons","in","a","tissue","which","has","had","part","of","its","nerve","supply","removed",",","and","they","can","often","innervate","successfully","any","cells","that","have","lost","some","or","all","of","their","original","synaptic","input","."),4106820). assertion_content_comment('tOboGo_CollateralSprouting',s("The","process","in","which","outgrowths","develop","from","the","shafts","of","existing","axons","."),4106657). assertion_content_comment('tOboGo_CollectinBinding',s("Interacting","selectively","and","non-covalently","with","a","collectin",",","a","member","of","a","group","of","structurally","related","pattern","recognition","molecules","characterized","by","having","a","carbohydrate","recognition","domain","of","the","C-type","lectin","family","at","the","C-terminus","and","a","collagenous","domain","at","the","N-terminus","."),4384340). assertion_content_comment('tOboGo_CollectingDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","collecting","duct","over","time",",","from","its","formation","to","the","mature","structure",".","The","collecting","duct","responds","to","vasopressin","and","aldosterone","to","regulate","water",",","electrolyte","and","acid-base","balance",".","It","is","the","final","common","path","through","which","urine","flows","before","entering","the","ureter","and","then","emptying","into","the","bladder","."),4123475). assertion_content_comment('tOboGo_CollectinReceptorActivity',s("Combining","with","a","collectin","to","initiate","a","change","in","cell","activity","."),4384350). assertion_content_comment('tOboGo_CollenchymaCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","collenchyma","cell",".","This","is","a","plant","cell","in","which","the","primary","cell","walls","are","unevenly","thickened",",","with","most","thickening","occurring","at","the","cell","corners",".","Cells","are","living","and","able","to","grow",",","they","are","elongated",",","and","lignin","and","secondary","walls","absent",".","Collenchyma","cells","make","up","collenchyma","tissue","which","acts","as","a","supporting","tissue","in","growing","shoots",",","leaves","and","petioles",".","This","tissue","is","often","arranged","in","cortical","ribs",",","as","seen","prominently","in","celery","and","rhubarb","petioles","."),4330143). assertion_content_comment('tOboGo_ColonyMorphology',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236168). assertion_content_comment('tOboGo_ColumbamineOxidaseActivity',s("Catalysis","of","the","reaction",":","2","columbamine","+","O","(","2",")","=","2","berberine","+","2","H","(","2",")","O","."),4266119). assertion_content_comment('tOboGo_Columella',s("A","rod-like","element","of","the","sexine","and","ectexine",",","supporting","either","the","tectum","(","the","layer","of","sexine","which","forms","a","roof","over","the","columella",")",",","or","supporting","a","caput","(","an","architectural","element","on","top","of","a","columella",")"),4095389). assertion_content_comment('tOboGo_ColumnarCuboidalEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","columnar/cuboidal","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","columnar/cuboidal","epithelial","cell","is","a","cell","usually","found","in","a","two","dimensional","sheet","with","a","free","surface",".","Columnar/cuboidal","epithelial","cells","take","on","the","shape","of","a","column","or","cube","."),3989950). assertion_content_comment('tOboGo_ColumnarCuboidalEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","columnar/cuboidal","epithelial","cell",".","A","columnar/cuboidal","epithelial","cell","is","a","cell","usually","found","in","a","two","dimensional","sheet","with","a","free","surface",".","Columnar/cuboidal","epithelial","cells","take","on","the","shape","of","a","column","or","cube","."),3989940). assertion_content_comment('tOboGo_ColumnarCuboidalEpithelialCellMaturation',s("The","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","columna/cuboidal","epithelial","cell","to","attain","its","fully","functional","state",".","A","columnar/cuboidal","epithelial","cell","is","a","cell","usually","found","in","a","two","dimensional","sheet","with","a","free","surface",".","Columnar/cuboidal","epithelial","cells","take","on","the","shape","of","a","column","or","cube","."),3989970). assertion_content_comment('tOboGo_COMAComplex',s("A","multiprotein","complex","in","yeast","consisting","of","Ctf19p",",","Okp1p",",","Mcm21p",",","and","Ame1p",".","This","complex","bridges","the","subunits","that","are","in","contact","with","centromeric","DNA","and","the","subunits","bound","to","microtubules","during","kinetochore","assembly","."),3978212). assertion_content_comment('tOboGo_Commensalism',s("An","interaction","between","two","organisms","living","together","in","more","or","less","intimate","association","in","a","relationship","in","which","one","benefits","and","the","other","is","unaffected","."),4083864). assertion_content_comment('tOboGo_CommissuralNeuronAxonGuidance',s("The","process","in","which","the","migration","of","an","axon","growth","cone","of","a","commissural","neuron","is","directed","to","its","target","in","the","brain","in","response","to","a","combination","of","attractive","and","repulsive","cues","."),4172403). assertion_content_comment('tOboGo_CommissuralNeuronDifferentiationInSpinalCord',s("The","process","in","which","neuroepithelial","cells","in","the","ventral","neural","tube","acquire","specialized","structural","and/or","functional","features","of","commissural","neurons",".","Commissural","neurons","in","both","vertebrates","and","invertebrates","transfer","information","from","one","side","of","their","bodies","to","the","other","through","the","midline",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","."),4041410). assertion_content_comment('tOboGo_CommitmentComplex',s("A","spliceosomal","complex","that","is","formed","by","association","of","the","U1","snRNP","with","the","5","'","splice","site","of","an","unspliced","intron","in","an","RNA","transcript","."),4346431). assertion_content_comment('tOboGo_CommitmentOfMultipotentStemCellsToNeuronalLineageInForebrain',s("The","initial","commitment","of","cells","whereby","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","some","type","of","neuron","in","the","forebrain","."),4047521). assertion_content_comment('tOboGo_CommitmentOfNeuronalCellToSpecificNeuronTypeInForebrain',s("The","commitment","of","neuronal","precursor","cells","to","become","specialized","types","of","neurons","in","the","forebrain","."),4048698). assertion_content_comment('tOboGo_CommitmentToApoptosis',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4232376). assertion_content_comment('tOboGo_CommonBileDuctDevelopment',s("The","progression","of","the","common","bile","duct","over","time",",","from","its","formation","to","the","mature","structure",".","The","common","bile","duct","is","formed","from","the","joining","of","the","common","hepatic","duct","running","from","the","liver",",","and","the","cystic","duct","running","from","the","gall","bladder",".","The","common","bile","duct","transports","bile","from","the","liver","and","gall","bladder","to","the","intestine","."),4113207). assertion_content_comment('tOboGo_CommonMyeloidProgenitorCellProliferation',s("The","multiplication","or","reproduction","of","common","myeloid","progenitor","cells",",","resulting","in","the","expansion","of","a","cell","population",".","A","common","myeloid","progenitor","cell","is","a","progenitor","cell","committed","to","the","myeloid","lineage","."),4380795). assertion_content_comment('tOboGo_CompactMyelin',s("The","portion","of","the","myelin","sheath","in","which","layers","of","cell","membrane","are","tightly","juxtaposed",",","completely","excluding","cytoplasm",".","The","juxtaposed","cytoplasmic","surfaces","form","the","major","dense","line",",","while","the","juxtaposed","extracellular","surfaces","form","the","interperiod","line","visible","in","electron","micrographs","."),4093084). assertion_content_comment('tOboGo_CompanionCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","companion","cell",".","The","companion","cell","is","the","specialized","parenchyma","cell","associated","with","a","sieve-tube","member","in","angiosperm","phloem","and","arising","from","the","same","mother","cell","as","the","sieve-tube","member","."),4104723). assertion_content_comment('tOboGo_CompartmentBoundaryMaintenance',s("A","homeostatic","process","involved","in","the","maintenance","of","a","compartment","boundary",".","A","compartment","boundary","is","a","lineage","restriction","boundary","within","a","developing","tissue","which","does","not","correspond","to","some","morphological","barrier","."),4115876). assertion_content_comment('tOboGo_CompartmentPatternFormation',s("The","regionalization","process","in","which","embryonic","segments","are","divided","into","compartments","that","will","result","in","differences","in","cell","differentiation","."),4115865). assertion_content_comment('tOboGo_CompetencePheromoneActivity',s("A","small","peptide","excreted","by","a","naturally","transformable","bacterium","(","e.g",".","Bacillus","subtilis",")","that","transmits","a","signal","required","for","the","establishment","of","competence","."),4309989). assertion_content_comment('tOboGo_CompetitionWithOtherOrganism',s("Any","process","in","which","an","organism","within","a","multispecies","community","gains","an","advantage","in","growth","or","survival","over","another","organism","of","a","different","species","in","that","community","."),4287665). assertion_content_comment('tOboGo_ComplementActivationAlternativePathway',s("Any","process","involved","in","the","activation","of","any","of","the","steps","of","the","alternative","pathway","of","the","complement","cascade","which","allows","for","the","direct","killing","of","microbes","and","the","regulation","of","other","immune","processes","."),4046267). assertion_content_comment('tOboGo_ComplementActivationClassicalPathway',s("Any","process","involved","in","the","activation","of","any","of","the","steps","of","the","classical","pathway","of","the","complement","cascade","which","allows","for","the","direct","killing","of","microbes",",","the","disposal","of","immune","complexes",",","and","the","regulation","of","other","immune","processes","."),4011360). assertion_content_comment('tOboGo_ComplementActivationLectinPathway',s("Any","process","involved","in","the","activation","of","any","of","the","steps","of","the","lectin","pathway","of","the","complement","cascade","which","allows","for","the","direct","killing","of","microbes","and","the","regulation","of","other","immune","processes","."),3986125). assertion_content_comment('tOboGo_ComplementActivation',s("Any","process","involved","in","the","activation","of","any","of","the","steps","of","the","complement","cascade",",","which","allows","for","the","direct","killing","of","microbes",",","the","disposal","of","immune","complexes",",","and","the","regulation","of","other","immune","processes",";","the","initial","steps","of","complement","activation","involve","one","of","three","pathways",",","the","classical","pathway",",","the","alternative","pathway",",","and","the","lectin","pathway",",","all","of","which","lead","to","the","terminal","complement","pathway","."),3986106). assertion_content_comment('tOboGo_ComplementActivity',s("OBSOLETE",".","Any","of","a","set","of","activities","involved","in","the","complement","cascade","."),4187768). assertion_content_comment('tOboGo_ComplementBinding',s("Interacting","selectively","and","non-covalently","with","any","component","or","product","of","the","complement","cascade","."),4200427). assertion_content_comment('tOboGo_ComplementComponentC1Complex',s("A","protein","complex","composed","of","six","subunits","of","C1q",",","each","formed","of","the","three","homologous","polypeptide","chains","C1QA",",","C1QB",",","and","C1QB",",","and","tetramer","of","two","C1QR","and","two","C1QS","polypeptide","chains","."),4007161). assertion_content_comment('tOboGo_ComplementComponentC1qBinding',s("Interacting","selectively","and","non-covalently","with","the","C1q","component","of","the","classical","complement","cascade","."),4384231). assertion_content_comment('tOboGo_ComplementComponentC1qReceptorActivity',s("Combining","with","the","C1q","component","of","the","classical","complement","cascade","to","initiate","a","change","in","cell","activity","."),4384301). assertion_content_comment('tOboGo_ComplementComponentC1rActivity',s("OBSOLETE",".","Catalysis","of","the","selective","cleavage","of","Lys","(","or","Arg",")","-Ile","bond","in","complement","subcomponent","C1s","to","form","the","active","form","of","C1s","(","EC",":","3.4.21.42",")"),4188173). assertion_content_comment('tOboGo_ComplementComponentC1sActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","component","C4","to","C4a","and","C4b","(","Arg-Ala","bond",")",",","and","component","C2","to","C2a","and","C2b","(","Lys-Lys","or","Arg-Lys","bond",")"),4188187). assertion_content_comment('tOboGo_ComplementComponentC2Complex',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220113). assertion_content_comment('tOboGo_ComplementComponentC3aBinding',s("Interacting","selectively","and","non-covalently","with","the","C3a","product","of","the","complement","cascade","."),4200476). assertion_content_comment('tOboGo_ComplementComponentC3aReceptorActivity',s("Combining","with","the","C3a","product","of","the","complement","cascade","to","initiate","a","change","in","cell","activity","."),4200439). assertion_content_comment('tOboGo_ComplementComponentC3bBinding',s("Interacting","selectively","and","non-covalently","with","the","C3b","product","of","the","complement","cascade","."),4384259). assertion_content_comment('tOboGo_ComplementComponentC3bReceptorActivity',s("Combining","with","the","C3b","product","of","the","complement","cascade","to","initiate","a","change","in","cell","activity","."),4200479). assertion_content_comment('tOboGo_ComplementComponentC3dBinding',s("Interacting","selectively","and","non-covalently","with","the","C3d","product","of","the","complement","cascade","."),4384249). assertion_content_comment('tOboGo_ComplementComponentC3dgBinding',s("Interacting","selectively","and","non-covalently","with","the","C3dg","product","of","the","complement","cascade","."),4384240). assertion_content_comment('tOboGo_ComplementComponentC3dgReceptorActivity',s("Combining","with","the","C3dg","product","of","the","complement","cascade","to","initiate","a","change","in","cell","activity","."),4384310). assertion_content_comment('tOboGo_ComplementComponentC3dReceptorActivity',s("Combining","with","the","C3d","product","of","the","complement","cascade","to","initiate","a","change","in","cell","activity","."),4384319). assertion_content_comment('tOboGo_ComplementComponentC4bBinding',s("Interacting","selectively","and","non-covalently","with","the","C4b","product","of","the","classical","complement","cascade","."),4384279). assertion_content_comment('tOboGo_ComplementComponentC4bReceptorActivity',s("Combining","with","the","C4b","product","of","the","classical","complement","cascade","to","initiate","a","change","in","cell","activity","."),4384330). assertion_content_comment('tOboGo_ComplementComponentC5aBinding',s("Interacting","selectively","and","non-covalently","with","the","C5a","product","of","the","complement","cascade","."),4200496). assertion_content_comment('tOboGo_ComplementComponentC5aReceptorActivity',s("Combining","with","the","C5a","product","of","the","complement","cascade","to","initiate","a","change","in","cell","activity","."),4200499). assertion_content_comment('tOboGo_ComplementComponentIC3bBinding',s("Interacting","selectively","and","non-covalently","with","the","iC3b","product","of","the","complement","cascade","."),4384269). assertion_content_comment('tOboGo_ComplementComponentIC3bReceptorActivity',s("Combining","with","the","iC3b","product","of","the","complement","cascade","to","initiate","a","change","in","cell","activity","."),4384290). assertion_content_comment('tOboGo_ComplementFactorDActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","component","factor","B","(","Arg-Lys",")","when","in","complex","with","C3b","or","with","cobra","venom","factor","(","CVF",")"),4188135). assertion_content_comment('tOboGo_ComplementFactorHActivity',s("OBSOLETE",".","A","cofactor","for","the","serine","protease","complement","factor","I","."),4306780). assertion_content_comment('tOboGo_ComplementFactorIActivity',s("OBSOLETE",".","Catalysis","of","the","inactivation","of","complement","subcomponents","C3b",",","iC3b","and","C4b","by","proteolytic","cleavage","."),4188152). assertion_content_comment('tOboGo_ComplementReceptorActivity',s("Combining","with","any","component","or","product","of","the","complement","cascade","to","initiate","a","change","in","cell","activity","."),4200430). assertion_content_comment('tOboGo_ComplementReceptorMediatedSignalingPathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","a","component","of","the","complement","pathway","binding","to","a","complement","receptor",".","Such","components","include","both","whole","complement","proteins","and","fragments","of","complement","proteins","generated","through","the","activity","of","the","complement","pathway","."),4381503). assertion_content_comment('tOboGo_CompoundEyeConeCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","compound","eye","cone","cell",",","a","cone-shaped","cell",",","that","focuses","light","in","a","compound","eye","."),4077966). assertion_content_comment('tOboGo_CompoundEyeConeCellFateCommitment',s("The","process","in","which","the","cone","cells","of","the","compound","eye",",","the","lens-secreting","cells","in","the","ommatidia",",","adopt","pathways","of","differentiation","that","lead","to","the","establishment","of","their","distinct","cell","type","."),4077968). assertion_content_comment('tOboGo_CompoundEyeConeCellFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","compound","eye","cone","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4078002). assertion_content_comment('tOboGo_CompoundEyeConeCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","compound","eye","cone","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4077979). assertion_content_comment('tOboGo_CompoundEyeCornealLensDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","corneal","lens","in","the","compound","eye","over","time",",","from","its","formation","to","the","mature","structure",".","The","corneal","lens","is","a","chitinous","extracellular","secretion","of","the","four","underlying","cone","cells","and","the","pigment","cells","."),4104549). assertion_content_comment('tOboGo_CompoundEyeCornealLensMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","compound","eye","corneal","lens","are","generated","and","organized","."),4104815). assertion_content_comment('tOboGo_CompoundEyeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","compound","eye","over","time",",","from","its","formation","to","the","mature","structure",".","The","compound","eye","is","an","organ","of","sight","that","contains","multiple","repeating","units",",","often","arranged","hexagonally",".","Each","unit","has","its","own","lens","and","photoreceptor","cell","(","s",")","and","can","generate","either","a","single","pixelated","image","or","multiple","images",",","per","eye","."),3985200). assertion_content_comment('tOboGo_CompoundEyeMorphogenesis',s("The","morphogenetic","process","in","which","the","anatomical","structures","of","the","compound","eye","are","generated","and","organized",".","The","adult","compound","eye","is","a","precise","assembly","of","700-800","ommatidia",".","Each","ommatidium","is","composed","of","20","cells",",","identified","by","cell","type","and","position",".","An","example","of","compound","eye","morphogenesis","is","found","in","Drosophila","melanogaster","."),3985203). assertion_content_comment('tOboGo_CompoundEyePhotoreceptorCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","eye","photoreceptor","cell","."),3985214). assertion_content_comment('tOboGo_CompoundEyePhotoreceptorDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","light-responsive","receptor","in","the","compound","eye","over","time",",","from","its","formation","to","the","mature","structure","."),4081624). assertion_content_comment('tOboGo_CompoundEyePhotoreceptorFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","compound","eye","photoreceptor","cell",".","A","photoreceptor","cell","is","a","cell","that","responds","to","incident","electromagnetic","radiation",".","Different","classes","of","photoreceptor","have","different","spectral","sensitivities","and","express","different","photosensitive","pigments","."),3985258). assertion_content_comment('tOboGo_CompoundEyePigmentation',s("Establishment","of","a","pattern","of","pigment","in","the","compound","eye","."),4104213). assertion_content_comment('tOboGo_CompoundEyeRetinalCellProgrammedCellDeath',s("Programmed","cell","death","that","occurs","in","the","retina","to","remove","excess","cells","between","ommatidia",",","thus","resulting","in","a","hexagonal","lattice",",","precise","with","respect","to","cell","number","and","position","surrounding","each","ommatidium","."),4099090). assertion_content_comment('tOboGo_CompoundLeafMorphogenesis',s("The","leaf","morphogenesis","process","that","results","in","the","shaping","of","a","compound","leaf",".","A","compound","leaf","is","a","leaf","having","two","or","more","distinct","leaflets","that","are","evident","as","such","from","early","in","development","."),4111246). assertion_content_comment('tOboGo_CondensedChromosomeCentromericRegion',s("The","region","of","a","condensed","chromosome","that","includes","the","centromere","and","associated","proteins",",","including","the","kinetochore",".","In","monocentric","chromosomes",",","this","region","corresponds","to","a","single","area","of","the","chromosome",",","whereas","in","holocentric","chromosomes",",","it","is","evenly","distributed","along","the","chromosome","."),3976721). assertion_content_comment('tOboGo_CondensedChromosomeInnerKinetochore',s("The","region","of","a","condensed","chromosome","kinetochore","closest","to","centromeric","DNA",";","in","mammals","the","CREST","antigens","(","CENP","proteins",")","are","found","in","this","layer",";","this","layer","may","help","define","underlying","centromeric","chromatin","structure","and","position","of","the","kinetochore","on","the","chromosome","."),3979488). assertion_content_comment('tOboGo_CondensedChromosomeKinetochore',s("A","multisubunit","complex","that","is","located","at","the","centromeric","region","of","a","condensed","chromosome","and","provides","an","attachment","point","for","the","spindle","microtubules","."),3976726). assertion_content_comment('tOboGo_CondensedChromosomeOuterKinetochore',s("The","region","of","a","condensed","chromosome","kinetochore","most","external","to","centromeric","DNA",";","this","outer","region","mediates","kinetochore-microtubule","interactions","."),3979502). assertion_content_comment('tOboGo_CondensedChromosome',s("A","highly","compacted","molecule","of","DNA","and","associated","proteins","resulting","in","a","cytologically","distinct","structure","."),3976716). assertion_content_comment('tOboGo_CondensedMesenchymalCellProliferation',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","condensed","mesenchymal","cell","population",".","A","condensed","mesenchymal","cell","population","is","a","population","of","adherent","mesenchymal","cells","."),4158170). assertion_content_comment('tOboGo_CondensedNuclearChromosomeCentromericRegion',s("The","region","of","a","condensed","chromosome","in","the","nucleus","that","includes","the","centromere","and","associated","proteins",",","including","the","kinetochore",".","In","monocentric","chromosomes",",","this","region","corresponds","to","a","single","area","of","the","chromosome",",","whereas","in","holocentric","chromosomes",",","it","is","evenly","distributed","along","the","chromosome","."),3978196). assertion_content_comment('tOboGo_CondensedNuclearChromosomeInnerKinetochore',s("The","region","of","a","condensed","nuclear","chromosome","kinetochore","closest","to","centromeric","DNA",";","this","layer","may","help","define","underlying","centromeric","chromatin","structure","and","position","of","the","kinetochore","on","the","chromosome","."),3979527). assertion_content_comment('tOboGo_CondensedNuclearChromosomeKinetochore',s("A","multisubunit","complex","that","is","located","at","the","centromeric","region","of","a","condensed","chromosome","in","the","nucleus","and","provides","an","attachment","point","for","the","spindle","microtubules","."),3978201). assertion_content_comment('tOboGo_CondensedNuclearChromosomeOuterKinetochore',s("The","region","of","a","condensed","nuclear","chromosome","kinetochore","most","external","to","centromeric","DNA",";","this","outer","region","mediates","kinetochore-microtubule","interactions","."),3979515). assertion_content_comment('tOboGo_CondensedNuclearChromosome',s("A","highly","compacted","molecule","of","DNA","and","associated","proteins","resulting","in","a","cytologically","distinct","structure","that","remains","in","the","nucleus","."),3978192). assertion_content_comment('tOboGo_CondensinComplex',s("A","multisubunit","protein","complex","that","plays","a","central","role","in","chromosome","condensation","."),3978343). assertion_content_comment('tOboGo_CondensinCoreHeterodimer',s("The","core","heterodimer","of","a","condensin","complex",",","a","multisubunit","protein","complex","that","plays","a","central","role","in","chromosome","condensation","."),3978411). assertion_content_comment('tOboGo_ConditionedTasteAversion',s("A","conditioned","aversion","to","a","specific","chemical","compound","as","a","result","of","that","compound","being","coupled","with","a","noxious","stimulus","."),4384098). assertion_content_comment('tOboGo_ConeCellPedicle',s("A","specialized","axon","terminus","which","is","produced","by","retinal","cone","cells",".","Pedicles","are","large",",","conical",",","flat","end-feet","(","8-10","micrometers","diameter",")","of","the","retinal","cone","axon","that","lie","more","or","less","side","by","side","on","the","same","plane","at","the","outer","edge","of","the","outer","plexiform","layer","(","OPL",")"),4287771). assertion_content_comment('tOboGo_ConidiophoreDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","conidiophore","over","time",",","from","its","formation","to","the","mature","structure",".","The","conidiophore","is","a","specialized","hypha","that","extends","aerially","from","the","growth","substrate","and","bears","conidia",",","or","asexual","spores","."),4132375). assertion_content_comment('tOboGo_ConidiophoreStalkDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","conidiophore","stalk","over","time",",","from","its","formation","to","the","mature","structure",".","The","conidiophore","stalk","is","part","of","a","specialized","hypha","that","extends","aerially","from","the","growth","substrate","and","supports","structures","from","which","conidia",",","or","asexual","spores",",","develop","."),4132502). assertion_content_comment('tOboGo_ConidiumFormation',s("Formation","of","asexual",",","nonmotile","spores","in","fungi",",","by","conversion","of","hyphal","elements","or","arising","from","specialized","sporogenous","cells","."),4148049). assertion_content_comment('tOboGo_ConiferinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","coniferin",",","4-","(","3-hydroxyprop-1-en-1-yl",")","-2-methoxyphenyl","beta-D-glucopyranoside","."),4339666). assertion_content_comment('tOboGo_ConjugantFormation',s("During","conjugation","without","cellular","fusion",",","the","process","that","results","in","pairing","complementary","mating","types",".","Localized","morphological",",","cytological",",","and","cytoskeletal","changes","connect","the","mating","types","without","cytoplasmic","mixing","."),3977776). assertion_content_comment('tOboGo_Conjugation',s("The","union","or","introduction","of","genetic","information","from","compatible","mating","types","that","results","in","a","genetically","different","individual",".","Conjugation","requires","direct","cellular","contact","between","the","organisms","."),3977406). assertion_content_comment('tOboGo_ConjugationWithCellularFusion',s("A","conjugation","process","that","results","in","the","union","of","cellular","and","genetic","information","from","compatible","mating","types",".","An","example","of","this","process","is","found","in","Saccharomyces","cerevisiae","."),3977418). assertion_content_comment('tOboGo_ConjugationWithMutualGeneticExchange',s("A","conjugation","process","that","results","in","the","mutual","exchange","and","union","of","only","genetic","information","between","compatible","mating","types",".","Conjugation","without","cellular","fusion","requires","direct","cellular","contact","between","the","organisms","without","plasma","membrane","fusion",".","The","organisms","involved","in","conjugation","without","cellular","fusion","separate","after","nuclear","exchange","."),3977719). assertion_content_comment('tOboGo_ConnectingTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","connecting","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","connecting","tubule","is","a","tubular","segment","of","the","nephron",";","it","connects","the","distal","convoluted","tubule","to","the","collecting","duct","."),4123854). assertion_content_comment('tOboGo_ConnectiveTissueGrowthFactorBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","CTGF",",","produced","by","human","umbilical","vein","endothelial","cells","and","by","skin","fibroblasts","after","activation","with","TGF-beta","."),4086031). assertion_content_comment('tOboGo_ConnectiveTissueGrowthFactorProduction',s("The","appearance","of","connective","tissue","growth","factor","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4066966). assertion_content_comment('tOboGo_ConnectiveTissueReplacementInvolvedInInflammatoryResponseWoundHealing',s("The","series","of","events","leading","to","growth","of","connective","tissue","when","loss","of","tissues","that","are","incapable","of","regeneration","occurs",",","or","when","fibrinous","exudate","cannot","be","adequately","cleared","that","contribute","to","an","inflammatory","response","."),3992219). assertion_content_comment('tOboGo_ConnexinBinding',s("Interacting","selectively","and","non-covalently","with","a","connexin",",","any","of","a","group","of","related","proteins","that","assemble","to","form","gap","junctions","."),4165693). assertion_content_comment('tOboGo_ConnexonComplex',s("An","assembly","of","six","molecules","of","connexin",",","made","in","the","Golgi","apparatus","and","subsequently","transported","to","the","plasma","membrane",",","where","docking","of","two","connexons","on","apposed","plasma","membranes","across","the","extracellular","space","forms","a","gap","junction","."),4008188). assertion_content_comment('tOboGo_Conoid',s("A","spiral","cytoskeletal","structure","located","at","the","apical","end","of","the","apical","complex","in","some","apicomplexan","parasites",".","Fibers","form","a","left-handed","spiral",",","and","are","comprised","of","tubulin","protofilaments","organized","in","a","ribbon-like","structure","that","differs","from","the","conventional","tubular","structure","characteristic","of","microtubules","."),4041720). assertion_content_comment('tOboGo_ConotoxinActivity',s("OBSOLETE",".","Acts","to","inhibit","neural","function","in","another","organism","by","inhibiting","voltage-gated","calcium","ion","channels","and","neurotransmitter","release",".","This","function","is","thought","to","be","specific","to","the","venom","of","two","marine","snail","species","."),4233664). assertion_content_comment('tOboGo_ConsequenceOfSignalTransmission',s("OBSOLETE",".","The","steps","whereby","the","downstream","processes","started","by","a","signal","are","brought","to","a","conclusion",".","Examples","include","destruction","of","cAMP","by","PDE",",","or","endocytosis","resulting","from","receptor","phosphorylation",".","The","termination","process","ends","when","the","receptor","has","returned","to","its","inactive","state","."),4346988). assertion_content_comment('tOboGo_ConstitutiveHydrogen_GlucoseSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","glucose","+","H","+","=","glucose","+","H","+","This","activity","is","constitutive","and","therefore","always","present",",","regardless","of","demand",".","Symporter","activity","enables","the","active","transport","of","a","solute","across","a","membrane","by","a","mechanism","whereby","two","or","more","species","are","transported","together","in","the","same","direction","in","a","tightly","coupled","process","not","directly","linked","to","a","form","of","energy","other","than","chemiosmotic","energy","."),4216474). assertion_content_comment('tOboGo_ConstitutiveProteinEctodomainProteolysis',s("The","proteolytic","cleavage","of","transmembrane","proteins","and","release","of","their","ectodomain","that","occurs","constantly",",","regardless","of","environmental","conditions","or","demands","."),4287147). assertion_content_comment('tOboGo_ConstitutiveSecretoryPathway',s("A","process","of","exocytosis","found","in","all","eukaryotic","cells",",","in","which","transport","vesicles","destined","for","the","plasma","membrane","leave","the","trans-Golgi","network","in","a","steady","stream",".","Upon","exocytosis",",","the","membrane","proteins","and","lipids","in","these","vesicles","provide","new","components","for","the","plasma","membrane",",","and","the","soluble","proteins","inside","the","vesicles","are","released","into","the","extracellular","space","."),4301072). assertion_content_comment('tOboGo_ContactGuidance',s("Cell","recognition","involving","the","deposition","of","specific","pathways","in","the","extracellular","matrix","that","guide","migrating","cells","."),4262872). assertion_content_comment('tOboGo_ContactInhibition',s("The","cellular","process","in","which","cells","stop","growing","or","dividing","in","response","to","increased","cell","density","."),4115336). assertion_content_comment('tOboGo_ContactSite',s("Sites","of","close","apposition","of","the","inner","and","outer","mitochondrial","membrane","."),4288187). assertion_content_comment('tOboGo_ContractileActinFilamentBundleAssembly',s("Assembly","of","actin","filament","bundles","in","which","the","filaments","are","loosely","packed","(","approximately","30-60","nm","apart",")","and","arranged","with","opposing","polarities",";","the","loose","packing","allows","myosin","(","usually","myosin-II",")","to","enter","the","bundle","."),4306878). assertion_content_comment('tOboGo_ContractileFiberPart',s("Any","constituent","part","of","a","contractile","fiber",",","a","fiber","composed","of","actin",",","myosin",",","and","associated","proteins",",","found","in","cells","of","smooth","or","striated","muscle","."),4008493). assertion_content_comment('tOboGo_ContractileFiber',s("Fibers",",","composed","of","actin",",","myosin",",","and","associated","proteins",",","found","in","cells","of","smooth","or","striated","muscle","."),4008488). assertion_content_comment('tOboGo_ContractileRingContractionInvolvedInCellCycleCytokinesis',s("The","process","of","an","actomyosin","ring","getting","smaller","in","diameter",",","in","the","context","of","cytokinesis","that","takes","place","as","part","of","a","cell","cycle","."),3978573). assertion_content_comment('tOboGo_ContractileRingLocalizationInvolvedInCellCycleCytokinesis',s("The","process","in","which","a","contractile","ring","is","assembled","and/or","maintained","in","a","specific","location",",","in","the","context","of","cytokinesis","that","takes","place","as","part","of","a","cell","cycle","."),4055378). assertion_content_comment('tOboGo_ContractileRingMaintenanceInvolvedInCellCycleCytokinesis',s("The","cell","cycle","process","in","which","the","contractile","ring","is","maintained","in","response","to","the","cytokinesis","checkpoint",";","that","is","when","cytokinesis","is","delayed","awaiting","completion","of","nuclear","division","or","the","correct","formation","of","cytokinetic","structures",".","This","process","occurs","in","the","context","of","cytokinesis","that","takes","place","as","part","of","a","cell","cycle","."),4055359). assertion_content_comment('tOboGo_ContractileRing',s("A","cytoskeletal","structure","composed","of","filamentous","protein","that","forms","beneath","the","membrane","of","many","cells","or","organelles",",","in","the","plane","of","cell","or","organelle","division",".","Ring","contraction","is","associated","with","centripetal","growth","of","the","membrane","that","divides","the","cytoplasm","of","the","two","daughter","cells","or","organelles","."),3971824). assertion_content_comment('tOboGo_ContractileVacuolarMembrane',s("The","lipid","bilayer","surrounding","the","contractile","vacuole","."),4057177). assertion_content_comment('tOboGo_ContractileVacuoleDischarge',s("The","regulated","release","of","water","from","a","contractile","vacuole","to","the","outside","of","a","cell","by","fusion","of","the","contractile","vacuole","membrane","with","the","plasma","membrane","."),4179095). assertion_content_comment('tOboGo_ContractileVacuoleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","contractile","vacuole",".","A","specialized","vacuole","that","fills","with","water","from","the","cytoplasm","and","then","discharges","this","externally","by","the","opening","of","contractile","vacuole","pores","."),4338275). assertion_content_comment('tOboGo_ContractileVacuolePore',s("Stable","structure","that","regulates","the","flow","of","liquid","between","the","contractile","vacuole","and","the","surrounding","medium","."),4057193). assertion_content_comment('tOboGo_ContractileVacuole',s("A","specialized","vacuole","of","eukaryotic","cells",",","especially","Protozoa",",","that","fills","with","water","from","the","cytoplasm","and","then","discharges","this","externally","by","the","opening","of","contractile","vacuole","pores",".","Its","function","is","probably","osmoregulatory","."),4057175). assertion_content_comment('tOboGo_ConusArteriosusDevelopment',s("The","progression","of","the","conus","arteriosus","over","time",",","from","its","formation","to","the","mature","structure",".","The","conus","arteriosus","is","a","valved","chamber","with","thick","muscular","walls","stemming","from","the","ventricle","and","connecting","to","the","pulmonary","trunk","."),4002693). assertion_content_comment('tOboGo_ConusArteriosusFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","conus","arteriosus","from","unspecified","parts",".","The","conus","arteriosus","is","a","valved","chamber","with","thick","muscular","walls","stemming","from","the","ventricle","and","connecting","to","the","pulmonary","trunk","."),4002713). assertion_content_comment('tOboGo_ConusArteriosusMorphogenesis',s("The","process","in","which","the","conus","arteriosus","is","generated","and","organized",".","The","conus","arteriosus","is","a","valved","chamber","with","thick","muscular","walls","stemming","from","the","ventricle","and","connecting","to","the","pulmonary","trunk","."),4002703). 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assertion_content_comment('tOboGo_CopperIonTransport',s("The","directed","movement","of","copper","(","Cu",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4159610). assertion_content_comment('tOboGo_CopperSensitivityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4300002). assertion_content_comment('tOboGo_CopperUptakeTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Cu","+","(","out",")","=","Cu","+","(","in",")"),4297673). 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assertion_content_comment('tOboGo_CoreRNAPolymeraseIIIBindingTranscriptionFactorActivity',s("Interacting","selectively","and","non-covalently","with","an","RNA","polymerase","III","(","Pol","III",")","complex",",","typically","composed","of","seventeen","subunits",",","in","order","to","modulate","transcription","by","Pol","III","."),4356283). assertion_content_comment('tOboGo_CoreRNAPolymeraseIIRecruitingTranscriptionFactorActivity',s("Interacting","selectively","and","non-covalently","with","an","RNA","polymerase","II","(","Pol","II",")","complex",",","typically","composed","of","twelve","subunits",",","in","order","to","facilitate","the","aggregation",",","arrangement","and","bonding","together","of","proteins","on","an","RNA","polymerase","II","promoter","DNA","to","form","the","transcriptional","preinitiation","complex","(","PIC",")",",","the","formation","of","which","is","a","prerequisite","for","transcription","by","RNA","polymerase","."),4358493). 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assertion_content_comment('tOboGo_CoreTFIIHComplex',s("The","5","subunit","core","of","TFIIH","that","has","tightly","associated","subunits","and","is","found","in","both","the","general","transcription","factor","holo-TFIIH","and","in","the","nucleotide-excision","repair","factor","3","complex",".","In","S",".","cerevisiae",",","it","is","composed","of","Rad3",",","Tfb1",",","Tfb2",",","Ssl1",",","Tfb4",".","In","humans",",","it","is","composed","of","XPD",",","p62",",","p55",",","p44",",","p34","."),3976574). assertion_content_comment('tOboGo_CorneocyteDesquamation',s("The","delamination","process","that","results","in","the","shedding","of","a","corneocyte","from","the","surface","of","the","epidermis","."),4006333). 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assertion_content_comment('tOboGo_CorollaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","corolla","over","time",",","from","its","formation","to","the","mature","structure","."),4032410). assertion_content_comment('tOboGo_CoronalSutureMorphogenesis',s("The","process","in","which","the","coronal","suture","is","generated","and","organized","."),4160282). assertion_content_comment('tOboGo_CoronaryArteryMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","coronary","arteries","are","generated","and","organized",".","Coronary","arteries","are","blood","vessels","that","transport","blood","to","the","heart","muscle","."),4156730). assertion_content_comment('tOboGo_CoronarySinusValveDevelopment',s("The","progression","of","the","valve","of","the","coronary","sinus","over","time",",","from","its","formation","to","the","mature","structure","."),4002187). assertion_content_comment('tOboGo_CoronarySinusValveFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","coronary","sinus","valve","from","unspecified","parts",".","This","process","begins","with","the","specific","processes","that","contribute","to","the","appearance","of","the","discrete","structure","and","ends","when","the","structural","rudiment","is","recognizable","."),4002356). assertion_content_comment('tOboGo_CoronarySinusValveMorphogenesis',s("The","process","in","which","the","structure","of","the","coronary","sinus","valve","is","generated","and","organized","."),4002197). assertion_content_comment('tOboGo_CoronaryVasculatureDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","blood","vessels","of","the","heart","over","time",",","from","its","formation","to","the","mature","structure","."),4002425). assertion_content_comment('tOboGo_CoronaryVasculatureMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","blood","vessels","of","the","heart","are","generated","and","organized",".","The","blood","vessel","is","the","vasculature","carrying","blood","."),4002432). assertion_content_comment('tOboGo_CoronaryVeinMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","veins","of","the","heart","are","generated","and","organized","."),4193837). assertion_content_comment('tOboGo_CorporaQuadrigeminaDevelopment',s("The","progression","of","the","corpora","quadrigemina","over","time",",","from","its","formation","to","the","mature","structure",".","The","corpora","quadrigemina","is","a","part","of","the","midbrain","that","is","made","up","of","the","superior","and","inferior","colliculi","."),4133491). assertion_content_comment('tOboGo_CorpusCallosumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","corpus","callosum","over","time",",","from","its","formation","to","the","mature","structure",".","The","corpus","callosum","is","a","thick","bundle","of","nerve","fibers","comprising","a","commissural","plate","connecting","the","two","cerebral","hemispheres",".","It","consists","of","contralateral","axon","projections","that","provide","communication","between","the","right","and","left","cerebral","hemispheres","."),4041054). assertion_content_comment('tOboGo_CorpusCallosumMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","corpus","callosum","are","generated","and","organized",".","The","corpus","callosum","is","a","thick","bundle","of","nerve","fibers","comprising","a","commissural","plate","connecting","the","two","cerebral","hemispheres",".","It","consists","of","contralateral","axon","projections","that","provides","communications","between","the","right","and","left","cerebral","hemispheres","."),4041109). assertion_content_comment('tOboGo_CorrinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","corrin",",","C19H22N4",",","the","fundamental","heterocyclic","skeleton","of","the","corrinoids",".","It","consists","of","four","reduced","pyrrole","rings","joined","into","a","macrocyclic","ring",".","Corrin","is","the","core","of","the","vitamin","B12","molecule","."),4351935). assertion_content_comment('tOboGo_CorrinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","corrin",",","C19H22N4",",","the","fundamental","heterocyclic","skeleton","of","the","corrinoids",".","It","consists","of","four","reduced","pyrrole","rings","joined","into","a","macrocyclic","ring",".","Corrin","is","the","core","of","the","vitamin","B12","molecule","."),4351951). assertion_content_comment('tOboGo_CorrinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","corrin",",","C19H22N4",",","the","fundamental","heterocyclic","skeleton","of","the","corrinoids",".","It","consists","of","four","reduced","pyrrole","rings","joined","into","a","macrocyclic","ring",".","Corrin","is","the","core","of","the","vitamin","B12","molecule","."),4296682). assertion_content_comment('tOboGo_CorticalActinCytoskeletonOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","actin-based","cytoskeletal","structures","in","the","cell","cortex",",","i.e",".","just","beneath","the","plasma","membrane","."),4307061). assertion_content_comment('tOboGo_CorticalActinCytoskeletonStabilization',s("The","process","in","which","the","assembly","and","arrangement","of","cytoskeletal","structures","in","the","actin","cortex","with","respect","to","the","plasma","membrane","is","maintained","."),4347744). assertion_content_comment('tOboGo_CorticalActinCytoskeleton',s("The","portion","of","the","actin","cytoskeleton",",","comprising","filamentous","actin","and","associated","proteins",",","that","lies","just","beneath","the","plasma","membrane","."),4015168). 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assertion_content_comment('tOboGo_CorticalMicrotubule',s("Arrays","of","microtubules","underlying","and","connected","to","the","plasma","membrane","in","the","cortical","cytosol","."),4107877). assertion_content_comment('tOboGo_CorticalMicrotubuleTransverseToLongAxis',s("Arrays","of","microtubules","underlying","and","connected","to","the","plasma","membrane",",","in","the","cortical","cytosol",",","oriented","mainly","with","their","axes","transverse","to","the","long","axis","of","the","cell","(","and","root","in","plants",")","In","plants","it","influences","the","direction","of","cellulose","microfibril","deposition","."),4329933). assertion_content_comment('tOboGo_CorticalProteinAnchoring',s("A","process","in","which","a","protein","or","protein","complex","is","maintained","in","a","specific","location","in","the","cell","cortex","."),4330417). assertion_content_comment('tOboGo_CorticospinalNeuronAxonDecussation',s("The","process","in","which","the","migration","of","an","axon","growth","cone","of","a","pyramidal","cell","that","is","part","of","the","corticospinal","tract","is","directed","to","cross","the","midline","to","the","contralateral","side","."),4048218). assertion_content_comment('tOboGo_CorticospinalNeuronAxonGuidance',s("The","process","in","which","the","migration","of","an","axon","growth","cone","of","a","neuron","that","is","part","of","the","corticospinal","tract","is","directed","from","the","cerebral","cortex","layer","V","to","the","spinal","cord","dorsal","funiculus","in","response","to","a","combination","of","attractive","and","repulsive","cues","."),4048170). 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assertion_content_comment('tOboGo_CORVETComplex',s("A","multimeric","protein","complex","that","acts","as","an","endosomal","tethering","complex","(","CORVET","=","class","C","core","vacuole/endosome","tethering",")","by","cooperating","with","Rab","GTPases","to","capture","endosomal","vesicles","and","trap","them","prior","to","the","action","of","SNAREs",";","the","complex","is","involved","in","endo-lysosomal","biogenesis","and","required","for","transport","between","endosome","and","vacuole",".","The","Saccharomyces","cerevisiae","complex","contains","Vps8p",",","Vps3p",",","Pep5p",",","Vps16p",",","Pep3p",",","and","Vps33p","."),4337985). assertion_content_comment('tOboGo_CorydalineSynthaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","2","NADPH","+","palmatine","=","S-adenosyl-L-homocysteine","+","corydaline","+","2","NADP","(","+",")"),4277827). assertion_content_comment('tOboGo_Costamere',s("Regular","periodic","sub","membranous","arrays","of","vinculin","in","skeletal","and","cardiac","muscle","cells",",","these","arrays","link","Z-discs","to","the","sarcolemma","and","are","associated","with","links","to","extracellular","matrix","."),4094097). assertion_content_comment('tOboGo_CotranscriptionalGeneSilencingBySmallRNA',s("A","process","in","which","the","targeting","of","nascent","transcripts","by","the","RITS","complex","mediates","chromatin","modifications","and","promotes","the","degradation","of","nascent","transcripts","synthesized","in","heterochromatic","regions","."),4341124). assertion_content_comment('tOboGo_CotranscriptionalInsertionOrDeletionEditing',s("OBSOLETE",".","The","insertion","into","or","deletion","from","an","RNA","molecule","of","nucleotide","residues","not","encoded","in","DNA",";","takes","place","during","transcription","."),4305269). assertion_content_comment('tOboGo_CotranscriptionalMitochondrialRRNANucleotideInsertion',s("The","insertion","of","one","or","two","non-coded","nucleotides","during","the","transcription","of","a","mitochondrial","rRNA",".","Such","additions","are","known","to","occur","in","myxomycetes","such","as","Physarum",",","Didymium",",","and","Stemonitis","."),4374559). assertion_content_comment('tOboGo_CotranslationalProteinTargetingToMembrane',s("The","targeting","of","proteins","to","a","membrane","that","occurs","during","translation",".","The","transport","of","most","secretory","proteins",",","particularly","those","with","more","than","100","amino","acids",",","into","the","endoplasmic","reticulum","lumen","occurs","in","this","manner",",","as","does","the","import","of","some","proteins","into","mitochondria","."),4013851). assertion_content_comment('tOboGo_CotyledonDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","cotyledon","over","time",",","from","its","formation","to","the","mature","structure",".","The","cotyledon","is","the","modified","leaf","(","seed","leaf",")",",","found","as","part","of","the","embryo","in","plant","seeds",".","It","is","involved","in","either","storage","or","absorption","of","food","reserves",".","Dicotyledonous","seeds","contain","two","cotyledons",",","while","monocotyledonous","seeds","contain","only","one",".","The","cotyledons","may","appear","above","ground","and","show","photosynthetic","activity","in","the","seedling","."),4105570). assertion_content_comment('tOboGo_CotyledonMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","cotyledon","are","generated","and","organized",".","The","cotyledon","is","the","modified","leaf","(","seed","leaf",")",",","found","as","part","of","the","embryo","in","plant","seeds",".","It","is","involved","in","either","storage","or","absorption","of","food","reserves",".","Dicotyledonous","seeds","contain","two","cotyledons",",","while","monocotyledonous","seeds","contain","only","one",".","The","cotyledons","may","appear","above","ground","and","show","photosynthetic","activity","in","the","seedling","."),4105582). assertion_content_comment('tOboGo_CotyledonVascularTissuePatternFormation',s("Vascular","tissue","pattern","formation","as","it","occurs","in","the","cotyledon","of","vascular","plants","."),4336299). assertion_content_comment('tOboGo_CoumarinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","coumarins",",","a","class","of","compounds","derived","from","the","phenylacrylic","skeleton","of","cinnamic","acids","."),4262289). assertion_content_comment('tOboGo_CoumarinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","coumarins",",","compounds","derived","from","the","phenylacrylic","skeleton","of","cinnamic","acids","."),4354184). assertion_content_comment('tOboGo_CoumarinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","coumarins",",","compounds","derived","from","the","phenylacrylic","skeleton","of","cinnamic","acids","."),4026446). assertion_content_comment('tOboGo_CourtshipBehavior',s("The","behavioral","interactions","between","organisms","for","the","purpose","of","attracting","sexual","partners","."),4014918). assertion_content_comment('tOboGo_CovalentChromatinModification',s("The","alteration","of","DNA","or","protein","in","chromatin","by","the","covalent","addition","or","removal","of","chemical","groups","."),3975555). assertion_content_comment('tOboGo_CranialNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","cranial","nerves","over","time",",","from","its","formation","to","the","mature","structure",".","The","cranial","nerves","are","composed","of","twelve","pairs","of","nerves","that","emanate","from","the","nervous","tissue","of","the","hindbrain",".","These","nerves","are","sensory",",","motor",",","or","mixed","in","nature",",","and","provide","the","motor","and","general","sensory","innervation","of","the","head",",","neck","and","viscera",".","They","mediate","vision",",","hearing",",","olfaction","and","taste","and","carry","the","parasympathetic","innervation","of","the","autonomic","ganglia","that","control","visceral","functions","."),4043754). 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assertion_content_comment('tOboGo_CranialNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","cranial","nerve","to","attain","its","fully","functional","state",".","The","cranial","nerves","are","composed","of","twelve","pairs","of","nerves","that","emanate","from","the","nervous","tissue","of","the","hindbrain",".","These","nerves","are","sensory",",","motor",",","or","mixed","in","nature",",","and","provide","the","motor","and","general","sensory","innervation","of","the","head",",","neck","and","viscera",".","They","mediate","vision",",","hearing",",","olfaction","and","taste","and","carry","the","parasympathetic","innervation","of","the","autonomic","ganglia","that","control","visceral","functions","."),4043848). assertion_content_comment('tOboGo_CranialNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","cranial","nerves","are","generated","and","organized",".","The","cranial","nerves","are","composed","of","twelve","pairs","of","nerves","that","emanate","from","the","nervous","tissue","of","the","hindbrain",".","These","nerves","are","sensory",",","motor",",","or","mixed","in","nature",",","and","provide","the","motor","and","general","sensory","innervation","of","the","head",",","neck","and","viscera",".","They","mediate","vision",",","hearing",",","olfaction","and","taste","and","carry","the","parasympathetic","innervation","of","the","autonomic","ganglia","that","control","visceral","functions","."),4043756). assertion_content_comment('tOboGo_CranialNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","cranial","nerves",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","cranial","nerves","are","composed","of","twelve","pairs","of","nerves","that","emanate","from","the","nervous","tissue","of","the","hindbrain",".","These","nerves","are","sensory",",","motor",",","or","mixed","in","nature",",","and","provide","the","motor","and","general","sensory","innervation","of","the","head",",","neck","and","viscera",".","They","mediate","vision",",","hearing",",","olfaction","and","taste","and","carry","the","parasympathetic","innervation","of","the","autonomic","ganglia","that","control","visceral","functions","."),4043872). assertion_content_comment('tOboGo_CranialSutureMorphogenesis',s("The","process","in","which","the","cranial","suture","is","generated","and","organized","."),4115035). assertion_content_comment('tOboGo_CRDDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","CRD","(","context","dependent","regulatory",")","domain",",","a","domain","of","about","130","residues","that","is","the","most","divergent","region","among","the","LEF/TCF","proteins","."),4168165). assertion_content_comment('tOboGo_CreatinaseActivity',s("Catalysis","of","the","reaction",":","creatine","+","H","(","2",")","O","=","sarcosine","+","urea","."),4302198). assertion_content_comment('tOboGo_CreatineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","creatine",",","N-","[","amino","(","imino",")","methyl","]","-N-methylglycine",".","Creatine","is","formed","by","a","process","beginning","with","amidino","group","transfer","from","L-arginine","to","glycine","to","form","guanidinoacetate",",","followed","by","methyl","group","transfer","from","S-adenosyl-L-methionine","to","guanidinoacetate",";","it","is","then","is","phosphorylated","to","form","a","pool","that","stores","high","energy","phosphate","for","the","replenishment","of","ATP","during","periods","of","high",",","or","fluctuating","energy","demand",".","In","animals",",","most","creatine","is","transported","to","and","used","in","muscle","."),4230154). assertion_content_comment('tOboGo_CreatineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","creatine","=","N-phosphocreatine","+","ADP","+","2","H","(","+",")"),4212024). assertion_content_comment('tOboGo_CreatineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","creatine","(","N-","(","aminoiminomethyl",")","-N-methylglycine",")",",","a","compound","synthesized","from","the","amino","acids","arginine",",","glycine",",","and","methionine","that","occurs","in","muscle","."),4230127). assertion_content_comment('tOboGo_Creatine_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","creatine","(","out",")","+","Na","+","(","out",")","=","creatine","(","in",")","+","Na","+","(","in",")"),4215963). assertion_content_comment('tOboGo_CreatineTransporterActivity',s("Enables","the","directed","movement","of","creatine","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Creatine","is","a","compound","synthesized","from","the","amino","acids","arginine",",","glycine",",","and","methionine","that","occurs","in","muscle","."),4215960). assertion_content_comment('tOboGo_CreatineTransport',s("The","directed","movement","of","creatine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Creatine","is","a","compound","synthesized","from","the","amino","acids","arginine",",","glycine",",","and","methionine","that","occurs","in","muscle","."),4294278). assertion_content_comment('tOboGo_CreatininaseActivity',s("Catalysis","of","the","reaction",":","creatinine","+","H","(","2",")","O","=","creatine","."),4373822). assertion_content_comment('tOboGo_CreatinineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","creatinine",",","2-amino-1",",","5-dihydro-1-methyl-4H-imidazol-4-one",",","an","end","product","of","creatine","metabolism","and","a","normal","constituent","of","urine","."),4230196). assertion_content_comment('tOboGo_CreatinineCatabolicProcessToFormate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","creatinine","into","other","compounds",",","including","formate","."),4243964). assertion_content_comment('tOboGo_CreatinineDeaminaseActivity',s("Catalysis","of","the","reaction",":","creatinine","+","H2O","=","N-methylhydantoin","+","NH3","."),4373759). 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assertion_content_comment('tOboGo_CresolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cresol",",","a","mixture","of","the","aromatic","alcohol","isoforms","o-",",","p-",",","and","m-cresol",",","which","is","obtained","from","coal","tar","or","petroleum",".","The","isomers","are","used","as","disinfectants",",","textile","scouring","agents",",","surfactants","and","as","intermediates","in","the","manufacture","of","salicylaldehyde",",","coumarin",",","and","herbicides","as","well","as","being","a","major","component","of","creosote","."),4272120). assertion_content_comment('tOboGo_CristaeFormation',s("The","assembly","of","cristae",",","the","inwards","folds","of","the","inner","mitochondrial","membrane","."),4312326). assertion_content_comment('tOboGo_CristaJunction',s("Tubular","structures","of","relatively","uniform","size","that","connect","mitochondrial","cristae","to","the","inner","mitchondrial","membrane","."),4288150). assertion_content_comment('tOboGo_CrossBridgeCyclingInvolvedInRegulationOfTheVelocityOfShorteningInSkeletalMuscleContraction',s("A","process","in","which","cross","bridges","are","broken","and","reformed","during","filament","sliding","as","part","of","the","regulation","of","the","velocity","of","shortening","in","skeletal","muscle","contraction","."),4320959). assertion_content_comment('tOboGo_CrossBridgeFormationInvolvedInRegulationOfTheVelocityOfShorteningInSkeletalMuscleContraction',s("The","process","in","which","actin","and","myosin","interact",",","split","ATP","and","generate","force","during","skeletal","muscle","contraction",".","This","process","is","one","of","the","components","of","the","regulation","of","the","force","of","skeletal","muscle","contraction","."),4320950). assertion_content_comment('tOboGo_CrossoverJunctionEndodeoxyribonucleaseActivity',s("Catalysis","of","the","endonucleolytic","cleavage","at","a","junction","such","as","a","reciprocal","single-stranded","crossover","between","two","homologous","DNA","duplexes","(","Holliday","junction",")"),4250239). assertion_content_comment('tOboGo_CryingBehavior',s("The","behavior","in","which","an","organism","sheds","tears",",","often","accompanied","by","non-verbal","vocalizations","and","in","response","to","external","or","internal","stimuli","."),4159919). assertion_content_comment('tOboGo_CrystalCellDifferentiation',s("The","process","in","which","a","hemocyte","precursor","cell","acquires","the","characteristics","of","a","crystal","cell",",","a","class","of","cells","that","contain","crystalline","inclusions","and","are","involved","in","the","melanization","of","pathogenic","material","in","the","hemolymph","."),4078028). assertion_content_comment('tOboGo_Crystalloid',s("A","transient",",","cytoplasmic","organelle","found","in","Plasmodium","species","that","resembles","a","cytoplasmic","inclusion","body","and","whose","function","is","poorly","understood",".","Crystalloids","form","in","ookinetes","and","disappear","after","ookinete-to-oocyst","transformation","."),4287902). assertion_content_comment('tOboGo_CTDPhosphataseActivity',s("Catalysis","of","the","reaction",":","phospho-","(","DNA-directed","RNA","polymerase",")","+","H2O","=","(","DNA-directed","RNA","polymerase",")","+","phosphate","."),4253450). assertion_content_comment('tOboGo_CTPaseActivity',s("Catalysis","of","the","reaction",":","CTP","+","H2O","=","CDP","+","phosphate",".","May","or","may","not","be","coupled","to","another","reaction","."),4318338). assertion_content_comment('tOboGo_CTPBinding',s("Interacting","selectively","and","non-covalently","with","CTP",",","cytidine","5","'","-triphosphate","."),4375443). assertion_content_comment('tOboGo_CTPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","CTP",",","cytidine","5","'","-triphosphate","."),4222767). assertion_content_comment('tOboGo_CTPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","CTP",",","cytidine","5","'","-triphosphate","."),4223667). assertion_content_comment('tOboGo_CTP_GeranylgeraniolKinaseActivity',s("Catalysis","of","the","reaction",":","geranylgeraniol","+","CTP","=","all-trans-geranyl-geranyl","monophosphate","+","CDP","."),4192186). assertion_content_comment('tOboGo_CTPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","CTP",",","cytidine","triphosphate","."),4222763). assertion_content_comment('tOboGo_CTPReductaseActivity',s("Catalysis","of","the","reaction",":","dCTP","+","thioredoxin","disulfide","+","H2O","=","CTP","+","thioredoxin",".","Thioredoxin","disulfide","is","the","oxidized","form","of","thioredoxin","."),4223576). assertion_content_comment('tOboGo_CTPReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4223580). assertion_content_comment('tOboGo_CTPSalvage',s("Any","process","which","produces","cytidine","5","'","-triphosphate","(","CTP",")","from","derivatives","of","it",",","without","de","novo","synthesis","."),4288197). assertion_content_comment('tOboGo_CTPSynthaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","UTP","+","NH3","=","ADP","+","phosphate","+","CTP","."),4190040). assertion_content_comment('tOboGo_CucurbitadienolSynthaseActivity',s("Catalysis","of","the","reaction",":","oxidosqualene","=","cucurbitadienol","."),4361198). assertion_content_comment('tOboGo_CUL4RINGUbiquitinLigaseComplex',s("A","ubiquitin","ligase","complex","in","which","a","cullin","from","the","Cul4","family","and","a","RING","domain","protein","form","the","catalytic","core",";","substrate","specificity","is","conferred","by","an","adaptor","protein","."),4182947). assertion_content_comment('tOboGo_CullinDeneddylation',s("The","modification","of","cullins","by","removal","of","ubiquitin-like","protein","NEDD8","(","RUB1",")"),4111398). 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assertion_content_comment('tOboGo_CuneatusTractMorphogenesis',s("Generation","of","a","long","process","of","a","CNS","neuron",",","that","carries","efferent","(","outgoing",")","action","potentials","from","the","cell","body","in","the","dorsal","root","ganglion","towards","target","cells","in","the","medulla",".","This","axonal","process","is","a","member","of","those","that","make","up","the","cuneatus","tract",",","a","group","of","axons","that","are","from","neurons","involved","in","proprioception","from","the","upper","trunk","and","upper","limb","."),4047762). assertion_content_comment('tOboGo_CupricReductaseActivity',s("Catalysis","of","the","reaction",":","Cu","+","+","NAD","+","=","Cu2","+","+","NADH","."),4250194). assertion_content_comment('tOboGo_CupulaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","cupula","over","time",",","from","its","formation","to","the","mature","structure",".","The","cupula","is","secreted","by","mantle","cells","and","the","ciliary","bundles","of","all","of","the","hair","cells","of","the","neuromast","are","embedded","in","it",".","The","cupula","provides","a","mechanical","linkage","between","the","hair","cells","and","the","external","hydrodynamic","environment",".","The","cupula","of","superficial","neuromasts","grows","continuously",",","while","the","height","of","the","cupula","of","canal","neuromasts","is","limited","by","canal","diameter","."),4105802). assertion_content_comment('tOboGo_CURIComplex',s("A","protein","complex","that","is","involved","in","the","transcription","of","ribosomal","genes",".","In","Saccharomyces","this","complex","consists","of","Ckb2p",",","Utp22p",",","Rrp7p","andIfh1p","."),4331318). assertion_content_comment('tOboGo_CUTCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cryptic","unstable","transcripts","(","CUTs",")"),4167468). assertion_content_comment('tOboGo_CuticleChitinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cuticle","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues",",","found","in","cuticles","."),4010241). assertion_content_comment('tOboGo_CuticleChitinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cuticle","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues",",","found","in","cuticles","."),4225531). assertion_content_comment('tOboGo_CuticleChitinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cuticle","chitin",",","a","linear","polysaccharide","consisting","of","P-1",",","4-linked","N-acetyl-D-glucosamine","residues",",","found","in","cuticles","."),4010237). assertion_content_comment('tOboGo_CuticleDevelopment',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","cuticle",",","the","outer","layer","of","some","animals","and","plants",",","which","acts","to","prevent","water","loss","."),4010152). assertion_content_comment('tOboGo_CuticleHydrocarbonBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hydrocarbons","that","make","up","the","cuticle",",","the","outer","layer","of","some","animals","and","plants",",","which","acts","to","prevent","water","loss","."),4014678). assertion_content_comment('tOboGo_CuticlePatternFormation',s("The","regionalization","process","that","gives","rise","to","the","patterns","of","cell","differentiation","in","the","cuticle","."),4071231). assertion_content_comment('tOboGo_CuticlePigmentation',s("Establishment","of","a","pattern","of","pigment","in","the","cuticle","of","an","organism","."),4104064). assertion_content_comment('tOboGo_CuticularPlate',s("A","dense","network","of","actin","filaments","found","beneath","the","apical","cell","surface","of","hair","cells",",","and","into","which","stereocilia","are","inserted","."),4055524). assertion_content_comment('tOboGo_CutinaseActivity',s("Catalysis","of","the","reaction",":","cutin","+","H2O","=","cutin","monomers","."),4269392). assertion_content_comment('tOboGo_CutinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cutin",",","a","waxy","substance",",","which","combined","with","cellulose","forms","a","substance","nearly","impervious","to","water","and","constituting","the","cuticle","in","plants","."),4334053). assertion_content_comment('tOboGo_CutinTransport',s("The","directed","movement","of","cutin","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Cutin",",","which","consists","of","C16-18","fatty","acids",",","is","the","major","component","of","the","cuticle","that","covers","the","plant","surface","."),4181924). 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assertion_content_comment('tOboGo_CVTPathway',s("A","constitutive","biosynthetic","process","that","occurs","under","nutrient-rich","conditions",",","in","which","two","resident","vacuolar","hydrolases",",","aminopeptidase","I","and","alpha-mannosidase",",","are","sequestered","into","vesicles",";","these","vesicles","are","transported","to",",","and","then","fuse","with",",","the","vacuole",".","This","pathway","is","mostly","observed","in","yeast","."),4128899). assertion_content_comment('tOboGo_CVTVesicleAssembly',s("A","vesicle","organization","process","that","takes","place","as","part","of","the","CVT","pathway",",","and","results","in","the","formation","of","a","double","membrane-bounded","cytosolic","structure","that","sequesters","precursor","aminopeptidase","I","(","prAPI",")"),4128912). assertion_content_comment('tOboGo_CVTVesicleMembrane',s("The","double","lipid","bilayer","surrounding","a","CVT","vesicle","."),4065787). assertion_content_comment('tOboGo_CVTVesicle',s("A","cytosolic","vesicle","that","is","enclosed","by","a","double","membrane","and","is","implicated","in","the","cytoplasm","to","vacuole","targeting","pathway",".","These","vesicles","are","found","in","the","yeast","S",".","cerevisiae",",","and","contain","vacuolar","hydrolases",",","aminopeptidase","I","(","Ape1p",")","and","alpha-mannosidase","(","Ams1p",")"),4065777). assertion_content_comment('tOboGo_CX3CChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CX3C","chemokine","receptor","."),4323417). assertion_content_comment('tOboGo_CXCR1ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","CXCR1","chemokine","receptor","."),4298853). assertion_content_comment('tOboGo_CXCR2ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","CXCR2","chemokine","receptor","."),4298843). assertion_content_comment('tOboGo_CXCR3ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","the","CXCR3","chemokine","receptor","."),4384879). assertion_content_comment('tOboGo_CXCR4ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CXCR4","chemokine","receptor","."),4323288). assertion_content_comment('tOboGo_CXCR5ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CXCR5","chemokine","receptor","."),4323299). assertion_content_comment('tOboGo_CXCR6ChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","CXCR6","chemokine","receptor","."),4323310). assertion_content_comment('tOboGo_CXCRChemokineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","chemokine","receptor","in","the","CXCR","family","."),4217469). assertion_content_comment('tOboGo_CyanamideHydrataseActivity',s("Catalysis","of","the","reaction",":","urea","=","cyanamide","+","H","(","2",")","O","."),4273670). assertion_content_comment('tOboGo_CyanamideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cyanamide",",","NCNH2",",","a","cyanide","compound","which","has","been","used","as","a","fertilizer",",","defoliant","and","in","many","manufacturing","processes",".","It","often","occurs","as","the","calcium","salt",",","sometimes","also","referred","to","as","cyanamide",".","The","citrated","calcium","salt","is","used","in","the","treatment","of","alcoholism","."),4273331). assertion_content_comment('tOboGo_CyanateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cyanate",",","NCO-",",","the","anion","of","cyanic","acid","."),4354411). 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assertion_content_comment('tOboGo_CyanateTransport',s("The","directed","movement","of","cyanate",",","NCO-",",","the","anion","of","cyanic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290673). assertion_content_comment('tOboGo_CyanelleEnvelope',s("The","double","lipid","bilayer","enclosing","the","cyanelle","and","separating","its","contents","from","the","rest","of","the","cytoplasm",";","includes","the","intermembrane","space","."),4065862). assertion_content_comment('tOboGo_CyanelleMembrane',s("Either","of","the","lipid","bilayers","that","surround","a","cyanelle","and","form","the","cyanelle","envelope","."),4065872). 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assertion_content_comment('tOboGo_CyanelleStroma',s("The","space","enclosed","by","the","double","membrane","of","a","cyanelle","."),4076998). assertion_content_comment('tOboGo_CyanelleThylakoidLumen',s("The","volume","enclosed","by","a","cyanelle","thylakoid","membrane","."),4065882). assertion_content_comment('tOboGo_CyanelleThylakoidMembrane',s("The","lipid","bilayer","membrane","of","any","thylakoid","within","a","cyanelle","."),4065828). assertion_content_comment('tOboGo_CyanelleThylakoid',s("A","thylakoid","found","in","a","cyanelle",",","which","is","a","type","of","plastid","found","in","certain","algae",".","The","cyanelle","contains","a","photosynthetic","membrane","resembling","that","of","cyanobacteria","."),4021853). 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assertion_content_comment('tOboGo_CyanogenicGlycosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cyanogenic","glycosides",",","any","glycoside","containing","a","cyano","group","that","is","released","as","hydrocyanic","acid","on","acid","hydrolysis",";","such","compounds","occur","in","the","kernels","of","various","fruits","."),4245460). assertion_content_comment('tOboGo_CyanogenicGlycosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cyanogenic","glycosides",",","any","glycoside","containing","a","cyano","group","that","is","released","as","hydrocyanic","acid","on","acid","hydrolysis",";","such","compounds","occur","in","the","kernels","of","various","fruits","."),4313093). assertion_content_comment('tOboGo_CyanogenicGlycosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cyanogenic","glycosides",",","any","glycoside","containing","a","cyano","group","that","is","released","as","hydrocyanic","acid","on","acid","hydrolysis",";","such","compounds","occur","in","the","kernels","of","various","fruits","."),4245457). assertion_content_comment('tOboGo_CyanophoreDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","cyanophore","cell",".","Cyanophores","are","pigment","cells","derived","from","the","neural","crest",".","They","contain","a","blue","pigment","of","unknown","chemical","composition",".","The","pigment","is","stored","in","fibrous","organelles","termed","cyanosomes","."),4104847). assertion_content_comment('tOboGo_CyanophycinaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolytic","cleavage","of","multi-L-arginyl-poly-L-aspartic","acid","(","cyanophycin",";","a","water-insoluble","reserve","polymer",")","into","aspartate-arginine","dipeptides","."),4327046). assertion_content_comment('tOboGo_CyanophycinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cyanophycin",",","a","non-protein",",","non-ribosomally","produced","amino","acid","polymer","composed","of","an","aspartic","acid","backbone","and","arginine","side","groups","."),4326237). assertion_content_comment('tOboGo_CyanophycinSynthetaseActivity',s("Catalysis","of","the","ATP-dependent","polymerization","of","arginine","and","aspartate","to","multi-L-arginyl-poly-L-aspartic","acid","(","cyanophycin",";","a","water-insoluble","reserve","polymer",")"),4164792). assertion_content_comment('tOboGo_Cyanosome',s("A","tissue-specific",",","membrane-bounded","cytoplasmic","organelle","within","which","an","unknown","blue","pigment","is","localized",".","Cyanosomes","are","synthesized","in","cyanophores","and","are","blue","in","appearance","."),4326210). assertion_content_comment('tOboGo_CyanuricAcidAmidohydrolaseActivity',s("Catalysis","of","the","reaction",":","cyanuric","acid","+","H2O","=","biuret","+","CO2","."),4274742). assertion_content_comment('tOboGo_CyanuricAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cyanuric","acid",",","a","potential","degradation","product","of","triazine","herbicides","."),4314470). assertion_content_comment('tOboGo_CyanuricAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cyanuric","acid",",","a","suspected","gastrointestinal","or","liver","toxicant",",","and","a","potential","degradation","product","of","triazine","herbicides",",","such","as","atrazine","and","simazine",".","It","is","widely","used","for","the","stabilization","of","available","chlorine","in","swimming","pool","water","and","is","also","the","starting","compound","for","the","synthesis","of","many","organic","derivatives","."),4243897). assertion_content_comment('tOboGo_CyclamateSulfohydrolaseActivity',s("Catalysis","of","the","reaction",":","cyclohexylsulfamate","+","H","(","2",")","O","=","cyclohexylamine","+","sulfate","."),4274226). assertion_content_comment('tOboGo_CyclaseActivatorActivity',s("Increases","the","activity","of","an","enzyme","that","catalyzes","a","ring","closure","reaction","."),4246853). assertion_content_comment('tOboGo_CyclaseActivity',s("Catalysis","of","a","ring","closure","reaction","."),4182172). assertion_content_comment('tOboGo_CyclaseInhibitorActivity',s("Decreases","the","activity","of","an","enzyme","that","catalyzes","a","ring","closure","reaction","."),4311652). assertion_content_comment('tOboGo_CyclaseRegulatorActivity',s("Modulates","the","activity","of","an","enzyme","that","catalyzes","a","ring","closure","reaction","."),4246851). assertion_content_comment('tOboGo_CyclicNucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","cyclic","nucleotide",",","a","nucleotide","in","which","the","phosphate","group","is","in","diester","linkage","to","two","positions","on","the","sugar","residue","."),4310764). assertion_content_comment('tOboGo_CyclicNucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","cyclic","nucleotide",",","a","nucleotide","in","which","the","phosphate","group","is","in","diester","linkage","to","two","positions","on","the","sugar","residue","."),4027618). assertion_content_comment('tOboGo_CyclicNucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","cyclic","nucleotide",",","a","nucleotide","in","which","the","phosphate","group","is","in","diester","linkage","to","two","positions","on","the","sugar","residue","."),4050060). assertion_content_comment('tOboGo_CyclicNucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","cyclic","nucleotide",",","a","nucleotide","in","which","the","phosphate","group","is","in","diester","linkage","to","two","positions","on","the","sugar","residue","."),4027525). assertion_content_comment('tOboGo_CyclicNucleotideTransport',s("The","directed","movement","of","a","cyclic","nucleotide",",","any","nucleotide","in","which","phosphate","group","is","in","diester","linkage","to","two","positions","on","the","sugar","residue",",","into",",","out","of","or","within","a","cell","."),4176252). assertion_content_comment('tOboGo_CyclicPhotosyntheticPhosphorylation',s("A","photosynthetic","phosphorylation","process","in","which","ATP","synthesis","is","driven","by","a","proton","gradient","generated","across","the","thylakoid","membrane",".","Involves","only","photosystem","I","."),4262795). assertion_content_comment('tOboGo_CyclicPurineNucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","cyclic","nucleotide",",","a","nucleotide","in","which","the","phosphate","group","is","in","diester","linkage","to","two","positions","on","the","sugar","residue","and","the","base","is","a","purine","."),4191827). assertion_content_comment('tOboGo_CyclinBinding',s("Interacting","selectively","and","non-covalently","with","cyclins",",","proteins","whose","levels","in","a","cell","varies","markedly","during","the","cell","cycle",",","rising","steadily","until","mitosis",",","then","falling","abruptly","to","zero",".","As","cyclins","reach","a","threshold","level",",","they","are","thought","to","drive","cells","into","G2","phase","and","thus","to","mitosis","."),4312142). assertion_content_comment('tOboGo_CyclinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cyclins",",","proteins","whose","levels","in","a","cell","varies","markedly","during","the","cell","cycle",",","and","which","play","key","roles","in","regulating","cell","cycle","phase","transitions","."),4143791). assertion_content_comment('tOboGo_CycloartenolSynthaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2",",","3-epoxysqualene","=","cycloartenol","."),4301826). assertion_content_comment('tOboGo_CyclodieneResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4245982). assertion_content_comment('tOboGo_CyclodieneSusceptibilityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4304381). assertion_content_comment('tOboGo_CycloeucalenolCycloisomeraseActivity',s("Catalysis","of","the","reaction",":","cycloeucalenol","=","obtusifoliol","."),4373771). assertion_content_comment('tOboGo_CyclohexadienylDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-arogenate","+","NAD","+","=","L-tyrosine","+","NADH","+","CO2","."),4373681). assertion_content_comment('tOboGo_CyclohexanolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","cyclohexanol","+","NAD","+","=","cyclohexanone","+","NADH","+","H","+"),4277392). assertion_content_comment('tOboGo_CyclohexanolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cyclohexanol",",","the","monohydroxy","derivative","of","cyclohexane",".","It","is","used","as","a","solvent","and","blending","agent","."),4239213). assertion_content_comment('tOboGo_CyclohexanolOxidation',s("The","cyclohexanol","metabolic","process","in","which","cyclohexanol","is","converted","to","adipate","."),4239217). assertion_content_comment('tOboGo_CyclohexanoneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","A","+","cyclohexanone","=","AH","(","2",")","+","cyclohex-2-enone","."),4373696). assertion_content_comment('tOboGo_CyclohexanoneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","cyclohexanone","+","NADPH","+","H","+","+","O2","=","6-hexanolide","+","NADP","+","+","H2O","."),4276605). assertion_content_comment('tOboGo_Cycloheximide_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","H","+","(","out",")","+","cycloheximide","(","in",")","=","H","+","(","in",")","+","cycloheximide","(","out",")"),4296555). assertion_content_comment('tOboGo_CycloheximideTransporterActivity',s("Enables","the","directed","movement","of","cycloheximide","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Cycloheximide","is","an","antibiotic","produced","by","Streptomyces","which","interferes","with","protein","synthesis","in","eukaryotes","."),4295267). assertion_content_comment('tOboGo_CycloheximideTransport',s("The","directed","movement","of","cycloheximide","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Cycloheximide","is","an","antibiotic","produced","by","Streptomyces","which","interferes","with","protein","synthesis","in","eukaryotes","."),4295078). assertion_content_comment('tOboGo_CyclohexylamineOxidaseActivity',s("Catalysis","of","the","reaction",":","cyclohexylamine","+","O2","+","H2O","=","cyclohexanone","+","NH3","+","hydrogen","peroxide","."),4278433). assertion_content_comment('tOboGo_CyclohexylsulfamateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cyclohexylsulfamate",",","also","known","as","cyclamic","acid",".","Sodium","cyclohexylsulfamate","(","CHS-Na",")","was","a","widely","used","sweetening","agent","but","was","banned","because","of","the","suspicion","of","carcinogenicity","and","metabolic","conversion","to","cyclohexylamine","(","CHA",")",",","a","toxic","substance",".","It","is","now","used","as","a","fungicide","."),4273344). assertion_content_comment('tOboGo_CyclohydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","any","non-peptide","carbon-nitrogen","bond","in","a","cyclic","amidine",",","a","compound","of","the","form","R-C","(","=","NH",")","-NH2",",","in","a","reaction","that","involves","the","opening","of","a","ring","."),4185528). assertion_content_comment('tOboGo_CyclomaltodextrinaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","cyclomaltodextrin","=","linear","maltodextrin","."),4373731). assertion_content_comment('tOboGo_CyclomaltodextrinGlucanotransferaseActivity',s("Catalysis","of","the","cyclization","of","part","of","a","1",",","4-alpha-D-glucan","chain","by","formation","of","a","1",",","4-alpha-D-glucosidic","bond","."),4328812). assertion_content_comment('tOboGo_CyclooxygenasePathway',s("The","chemical","reactions","and","pathways","by","which","prostaglandins","are","formed","from","arachidonic","acid",",","and","in","which","prostaglandin-endoperoxide","synthase","(","cyclooxygenase",")","catalyzes","the","committed","step","in","the","conversion","of","arachidonic","acid","to","the","prostaglandin-endoperoxides","PGG2","and","PGH2","."),4045835). assertion_content_comment('tOboGo_CyclopentanolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cyclopentanol","."),4347526). assertion_content_comment('tOboGo_CyclopentanolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cyclopentanol","."),4347541). assertion_content_comment('tOboGo_CyclopentanolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","cyclopentanol","+","NAD","(","+",")","=","cyclopentanone","+","H","(","+",")","+","NADH","."),4221842). assertion_content_comment('tOboGo_CyclopentanolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cyclopentanol","."),4347514). assertion_content_comment('tOboGo_CyclopentanoneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","cyclopentanone","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","5-valerolactone","+","H","(","2",")","O","+","NADP","(","+",")"),4373718). assertion_content_comment('tOboGo_Cyclophilin',s("OBSOLETE",".","A","protein","to","which","cyclosporin","A","(","an","immunosuppressant",")","binds",".","Possesses","peptidyl-prolyl","isomerase","activity","."),4203631). assertion_content_comment('tOboGo_CyclosporinABinding',s("Interacting","selectively","and","non-covalently","with","cyclosporin","A",",","a","cyclic","undecapeptide","that","contains","several","N-methylated","and","unusual","amino","acids","."),4203627). assertion_content_comment('tOboGo_CysteamineDioxygenaseActivity',s("Catalysis","of","the","reaction",":","cysteamine","+","O","(","2",")","=","H","(","+",")","+","hypotaurine","."),4375397). assertion_content_comment('tOboGo_CysteineBiosyntheticProcessFromSerine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cysteine","from","other","compounds",",","including","serine","."),4231847). assertion_content_comment('tOboGo_CysteineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cysteine",",","2-amino-3-mercaptopropanoic","acid","."),4231841). assertion_content_comment('tOboGo_CysteineBiosyntheticProcessViaCystathionine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cysteine",",","via","the","intermediate","cystathionine","."),4240299). assertion_content_comment('tOboGo_CysteineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cysteine",",","2-amino-3-mercaptopropanoic","acid","."),4241596). assertion_content_comment('tOboGo_CysteineDesulfuraseActivity',s("Catalysis","of","the","reaction",":","L-cysteine","+","[","enzyme","]","-cysteine","=","L-alanine","+","[","enzyme","]","-S-sulfanylcysteine","."),4319232). assertion_content_comment('tOboGo_CysteineDioxygenaseActivity',s("Catalysis","of","the","reaction",":","L-cysteine","+","O","(","2",")","=","3-sulfino-L-alanine","+","H","(","+",")"),4258313). assertion_content_comment('tOboGo_CysteineExport',s("The","directed","movement","of","cysteine","out","of","a","cell","or","organelle","."),4338027). assertion_content_comment('tOboGo_CysteineHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","cysteine","within","an","organism","or","cell","."),4181049). assertion_content_comment('tOboGo_CysteineLyaseActivity',s("Catalysis","of","the","reaction",":","L-cysteine","+","sulfite","=","L-cysteate","+","sulfide","."),4375095). assertion_content_comment('tOboGo_CysteineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cysteine",",","2-amino-3-mercaptopropanoic","acid","."),4231794). assertion_content_comment('tOboGo_CysteineSulfinateDesulfinaseActivity',s("Catalysis","of","the","reaction",":","3-sulfinoalanine","=","L-alanine","+","sulfite","."),4250150). assertion_content_comment('tOboGo_CysteineSynthaseActivity',s("Catalysis","of","the","reaction",":","O3-acetyl-L-serine","+","hydrogen","sulfide","=","L-cysteine","+","acetate","."),4211647). assertion_content_comment('tOboGo_CysteineSynthaseComplex',s("Cysteine","synthase","is","a","multienzyme","complex","made","up",",","in","E",".","coli",",","of","the","heteromeric","hexamer","serine","acetyltransferase","and","the","homodimer","O-acetylserine","(","thiol",")","-lyase","A","."),4259726). assertion_content_comment('tOboGo_CysteineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","cysteine","from","one","side","of","the","membrane","to","the","other","."),4331521). assertion_content_comment('tOboGo_CysteineTransport',s("The","directed","movement","of","cysteine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4314987). assertion_content_comment('tOboGo_CysteinylLeukotrieneReceptorActivity',s("Combining","with","a","cysteinyl","leukotriene","to","initiate","a","change","in","cell","activity",".","Cysteinyl","leukotrienes","are","leukotrienes","that","contain","a","peptide","group","based","on","cysteine","."),4383907). assertion_content_comment('tOboGo_CysteinylLeukotrieneReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","cysteinyl","leukotriene","receptor","."),4322629). assertion_content_comment('tOboGo_CysticDuctDevelopment',s("The","progression","of","the","cystic","duct","over","time",",","from","its","formation","to","the","mature","structure",".","The","cystic","duct","runs","from","the","gall","bladder","to","the","common","bile","duct","."),4081935). assertion_content_comment('tOboGo_CysticFibrosisTransmembraneConductanceRegulatorBinding',s("Interacting","selectively","and","non-covalently","with","the","Cystic","Fibrosis","Transmembrane","conductance","Regulator","(","CFTR",")","protein","."),4316067). assertion_content_comment('tOboGo_CystineDiaminopimelatePorterActivity',s("OBSOLETE",".","Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","polar","amino","acid","(","out",")","=","ADP","+","phosphate","+","polar","amino","acid","(","in",")"),4289826). assertion_content_comment('tOboGo_Cystine_GlutamateAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","cystine","(","out",")","+","glutamate","(","in",")","=","cystine","(","in",")","+","glutamate","(","out",")"),4296427). assertion_content_comment('tOboGo_CystineReductaseActivity',s("Catalysis","of","the","reaction",":","2","L-cysteine","+","NAD","(","+",")","=","L-cystine","+","H","(","+",")","+","NADH","."),4266082). assertion_content_comment('tOboGo_CystineSecondaryActiveTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","cystine","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4296437). assertion_content_comment('tOboGo_CystoblastDivision',s("The","four","rounds","of","incomplete","mitosis","undergone","by","the","cystoblast","to","form","a","16-cell","cyst",".","Within","the","cyst",",","one","cell","differentiates","into","an","oocyte","while","the","rest","become","nurse","cells",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4017032). assertion_content_comment('tOboGo_CytidineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cytidine",",","cytosine","riboside",",","a","widely","distributed","nucleoside","."),4226094). assertion_content_comment('tOboGo_CytidineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cytidine",",","cytosine","riboside",",","a","widely","distributed","nucleoside","."),4226512). assertion_content_comment('tOboGo_CytidineDeaminaseActivity',s("Catalysis","of","the","reaction",":","cytidine","+","H2O","=","uridine","+","NH3","."),4211614). assertion_content_comment('tOboGo_CytidineDeamination',s("The","removal","of","amino","group","in","the","presence","of","water","."),4262077). assertion_content_comment('tOboGo_CytidineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","cytidine","=","ADP","+","CMP","."),4327945). assertion_content_comment('tOboGo_CytidineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cytidine",",","cytosine","riboside",",","a","widely","distributed","nucleoside","."),4226074). assertion_content_comment('tOboGo_CytidineSalvage',s("Any","process","that","generates","cytidine",",","cytosine","riboside",",","from","derivatives","of","it","without","de","novo","synthesis","."),4226100). assertion_content_comment('tOboGo_CytidineToUridineEditing',s("The","conversion","of","a","cytosine","residue","to","uridine","in","an","RNA","molecule","by","deamination","."),4305221). assertion_content_comment('tOboGo_CytidineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","cytidine",",","cytosine","riboside",",","from","one","side","of","a","membrane","to","the","other","."),4295631). assertion_content_comment('tOboGo_CytidineTransport',s("The","directed","movement","of","cytidine",",","cytosine","riboside",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293907). assertion_content_comment('tOboGo_CytidylateCyclaseActivity',s("Catalysis","of","the","reaction",":","CTP","=","3","'",",","5","'","-cyclic","CMP","+","diphosphate","+","H","(","+",")"),4375120). assertion_content_comment('tOboGo_CytidylateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","(","d",")","CMP","=","ADP","+","(","d",")","CDP","."),4211626). assertion_content_comment('tOboGo_CytidylyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","cytidylyl","group","to","an","acceptor","."),4174779). assertion_content_comment('tOboGo_CytoadherenceToMicrovasculatureMediatedBySymbiontProtein',s("The","adherence","of","symbiont-infected","erythrocytes","to","microvascular","endothelium","via","symbiont","proteins","embedded","in","the","membrane","of","the","erythrocyte","."),4079877). assertion_content_comment('tOboGo_CytochromeA',s("OBSOLETE",".","A","cytochrome","containing","heme","a","."),4259110). assertion_content_comment('tOboGo_CytochromeB5',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259066). assertion_content_comment('tOboGo_CytochromeB6fComplexAssembly',s("Formation","of","cytochrome","b6f","complex",",","a","complex","that","transfers","electrons","from","reduced","plastoquinone","to","oxidized","plastocyanin","and","translocates","protons","from","the","stroma","to","the","lumen",",","by","the","aggregation",",","arrangement","and","bonding","together","of","its","constituents","."),4333956). assertion_content_comment('tOboGo_CytochromeB6fComplex',s("Complex","that","transfers","electrons","from","reduced","plastoquinone","to","oxidized","plastocyanin","and","translocates","protons","from","the","stroma","to","the","lumen",".","The","complex","contains","a","core","structure","of","three","catalytic","subunits",":","cytochrome","b",",","the","Rieske","iron","sulfur","protein","(","ISP",")",",","and","cytochrome","f",",","which","are","arranged","in","an","integral","membrane-bound","dimeric","complex",";","additional","subunits","are","present",",","and","vary","among","different","species","."),4261721). assertion_content_comment('tOboGo_CytochromeB6',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4306590). 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assertion_content_comment('tOboGo_CytokineReceptorActivity',s("Combining","with","a","cytokine","to","initiate","a","change","in","cell","activity","."),4173636). assertion_content_comment('tOboGo_CytokineReceptorBinding',s("Interacting","selectively","with","a","cytokine","receptor","."),4176115). assertion_content_comment('tOboGo_CytokineSecretionInvolvedInImmuneResponse',s("The","regulated","release","of","cytokines","from","a","cell","or","group","of","cells","that","contributes","to","an","immune","response","."),3994290). assertion_content_comment('tOboGo_CytokineSecretion',s("The","regulated","release","of","cytokines","from","a","cell","or","group","of","cells",".","Cytokines","are","any","of","a","group","of","proteins","that","function","to","control","the","survival",",","growth","and","differentiation","of","tissues","and","cells",",","and","which","have","autocrine","and","paracrine","activity","."),3994285). assertion_content_comment('tOboGo_CytokinesisActomyosinContractileRingAssembly',s("The","process","of","assembly","of","a","ring","composed","of","actin",",","myosin",",","and","associated","proteins","that","will","function","in","cytokinesis","."),4129546). assertion_content_comment('tOboGo_CytokinesisAfterMeiosisII',s("A","cell","cycle","process","that","results","in","the","division","of","the","cytoplasm","of","a","cell","after","meiosis","II",",","resulting","in","the","separation","of","the","original","cell","into","two","daughter","cells","."),4236090). assertion_content_comment('tOboGo_CytokinesisAfterMeiosisI',s("A","cell","cycle","process","that","results","in","the","division","of","the","cytoplasm","of","a","cell","after","meiosis","I",",","resulting","in","the","separation","of","the","original","cell","into","two","daughter","cells","."),4236081). 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assertion_content_comment('tOboGo_CytokinesisByCellPlateFormation',s("The","process","of","dividing","the","cytoplasm","of","a","parent","cell","where","a","structure","forms","in","the","cytoplasm","and","grows","until","reaching","the","plasma","membrane",",","thereby","completely","separating","the","cytoplasms","of","adjacent","progeny","cells",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),3978616). assertion_content_comment('tOboGo_CytokinesisCheckpoint',s("A","cell","cycle","checkpoint","that","ensures","the","correct","temporal","ordering","of","nuclear","division","and","cytokinesis",";","arrests","the","cell","cycle","in","G2","upon","perturbation","of","cytokinetic","structures",".","In","Schizosaccharomyces",",","the","checkpoint","monitors","formation","and","integrity","of","medial","actomyosin","ring","and","septum","."),4126922). assertion_content_comment('tOboGo_CytokinesisCompletionOfSeparation',s("The","process","of","finishing","cell","separation",",","which","results","in","two","physically","separated","cells","."),4012490). assertion_content_comment('tOboGo_CytokinesisInitiationOfSeparation',s("The","process","involved","in","starting","cell","separation","."),4012479). assertion_content_comment('tOboGo_CytokinesisProteinRecruitment',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236019). assertion_content_comment('tOboGo_Cytokinesis',s("A","cellular","process","resulting","in","the","division","of","the","cytoplasm","of","a","cell","and","its","separation","into","two","daughter","cells",".","Cytokinesis","usually","occurs","after","growth",",","replication",",","and","segregation","of","cellular","components","."),3973962). assertion_content_comment('tOboGo_CytokinesisSensuViridiplantae',s("OBSOLETE",".","The","division","of","a","cell","into","two","daughter","cells","with","cell","walls","."),4261872). assertion_content_comment('tOboGo_CytokinesisSiteSelection',s("The","process","of","marking","the","place","where","cytokinesis","will","occur","."),3973994). assertion_content_comment('tOboGo_CytokineticCellSeparation',s("The","process","of","physically","separating","progeny","cells","during","cytokinesis",";","this","may","involve","enzymatic","digestion","of","septum","or","cell","wall","components","."),4012467). assertion_content_comment('tOboGo_CytokineticProcess',s("A","cellular","process","that","is","involved","in","the","division","of","the","cytoplasm","of","a","cell","and","its","separation","into","two","daughter","cells","."),3973992). assertion_content_comment('tOboGo_CytokininBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cytokinins",",","a","class","of","adenine-derived","compounds","that","can","function","in","plants","as","growth","regulators","."),4260839). assertion_content_comment('tOboGo_CytokininCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cytokinins",",","a","class","of","adenine-derived","compounds","that","can","function","in","plants","as","plant","growth","regulators","."),4262330). assertion_content_comment('tOboGo_CytokininDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","N6-dimethylallyladenine","+","acceptor","+","H2O","=","adenine","+","3-methylbut-2-enal","+","reduced","electron","acceptor","."),4237380). assertion_content_comment('tOboGo_CytokininMediatedSignalingPathway',s("A","series","of","molecular","signals","induced","by","the","detection","of","cytokinin","."),4148726). assertion_content_comment('tOboGo_CytokininMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cytokinins",",","a","class","of","adenine-derived","compounds","that","can","function","in","plants","as","growth","regulators","."),4260826). assertion_content_comment('tOboGo_CytokininReceptorActivity',s("Combining","with","a","cytokinin","to","initiate","a","change","in","cell","activity","."),4262276). assertion_content_comment('tOboGo_CytokininTransport',s("The","directed","movement","of","cytokinins",",","a","class","of","adenine-derived","compounds","that","can","function","in","plants","as","growth","regulators",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4333865). assertion_content_comment('tOboGo_CytolysisByHostOfSymbiontCells',s("The","killing","by","an","organism","of","a","cell","in","its","symbiont","organism","by","means","of","the","rupture","of","cell","membranes","and","the","loss","of","cytoplasm",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4122258). assertion_content_comment('tOboGo_CytolysisBySymbiontOfHostCells',s("The","killing","by","an","organism","of","a","cell","in","its","host","organism","by","means","of","the","rupture","of","cell","membranes","and","the","loss","of","cytoplasm",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3985821). assertion_content_comment('tOboGo_CytolysisInOtherOrganismInvolvedInSymbioticInteraction',s("The","killing","by","an","organism","of","a","cell","in","a","second","organism","by","means","of","the","rupture","of","cell","membranes","and","the","loss","of","cytoplasm",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3985750). assertion_content_comment('tOboGo_CytolysisInOtherOrganism',s("The","killing","by","an","organism","of","a","cell","in","another","organism","by","means","of","the","rupture","of","cell","membranes","and","the","loss","of","cytoplasm","."),3985744). assertion_content_comment('tOboGo_Cytolysis',s("The","rupture","of","cell","membranes","and","the","loss","of","cytoplasm","."),4079251). assertion_content_comment('tOboGo_CytolyticGranule',s("A","specialized","secretory","lysosome","that","is","present","in","cells","with","cytolytic","capability","such","as","cytotoxic","T","lymphocytes","and","natural","killer","cells",".","Cytolytic","granules","mediate","the","storage","and","regulated","excretion","of","lytic","molecules","for","killing","of","target","cells","."),4288383). assertion_content_comment('tOboGo_CytonemeAssembly',s("Formation","of","a","cytoneme",",","a","long",",","thin","and","polarized","actin-based","cytoplasmic","extension","that","projects","from","a","cell","."),4070909). assertion_content_comment('tOboGo_CytonemeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","cytoneme","are","shaped",".","A","cytoneme","is","a","long",",","thin","and","polarized","actin-based","cytoplasmic","extension","that","projects","from","a","cell","."),4070898). assertion_content_comment('tOboGo_Cytoneme',s("A","long",",","thin",",","polarized","cell","projection","that","contains","actin","and","can","extend","for","distances","many","times","the","diameter","of","the","cell",".","Cytonemes","represent","extensions","of","cell","cytoplasm","and","typically","have","a","diameter","of","approximately","0.2um","."),4382649). assertion_content_comment('tOboGo_CytoplasmicChromatin',s("The","ordered","and","organized","complex","of","DNA","and","protein","that","forms","the","chromosome","in","the","cytoplasm","."),3978459). assertion_content_comment('tOboGo_CytoplasmicChromosome',s("A","chromosome","found","in","the","cytoplasm","."),3973919). assertion_content_comment('tOboGo_CytoplasmicDNAReplicationFactorCComplex',s("A","cytoplasmic","complex","of","two","polypeptides","that","loads","the","DNA","polymerase","processivity","factor","proliferating","cell","nuclear","antigen","(","PCNA",")","onto","DNA",",","thereby","permitting","processive","DNA","synthesis","catalyzed","by","DNA","polymerase",".","Examples","of","this","component","are","found","in","prokaryotic","species","."),4094711). assertion_content_comment('tOboGo_CytoplasmicDyneinComplex',s("Any","dynein","complex","that","catalyzes","movement","along","a","cytoplasmic","microtubule",";","cytoplasmic","dynein","complexes","participates","in","many","transport","activities","in","eukaryotes",",","such","as","mRNA","localization",",","intermediate","filament","transport",",","nuclear","envelope","breakdown",",","apoptosis",",","transport","of","centrosomal","proteins",",","mitotic","spindle","assembly",",","virus","transport",",","kinetochore","functions",",","and","movement","of","signaling","and","spindle","checkpoint","proteins",".","Subunits","associated","with","the","dynein","heavy","chain","mediate","association","between","dynein","heavy","chain","and","cargoes",",","and","may","include","light","chains","and","light","intermediate","chains","."),4221576). assertion_content_comment('tOboGo_CytoplasmicDyneinHeavyChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383687). assertion_content_comment('tOboGo_CytoplasmicDyneinIntermediateChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383654). assertion_content_comment('tOboGo_CytoplasmicDyneinIntermediateLightChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383665). assertion_content_comment('tOboGo_CytoplasmicDyneinLightChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383834). assertion_content_comment('tOboGo_CytoplasmicExosomeRNaseComplex',s("Complex","of","3","'","-5","'","exoribonucleases","found","in","the","cytoplasm","."),4300671). assertion_content_comment('tOboGo_CytoplasmicInterphaseChromosome',s("OBSOLETE",".","A","chromosome","found","in","the","cytoplasm","during","interphase","."),4346228). assertion_content_comment('tOboGo_CytoplasmicMicrotubuleDepolymerization',s("The","removal","of","tubulin","heterodimers","from","one","or","both","ends","of","a","cytoplasmic","microtubule","."),4034952). assertion_content_comment('tOboGo_CytoplasmicMicrotubuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","structures","formed","of","microtubules","and","associated","proteins","in","the","cytoplasm","of","a","cell","."),4034948). assertion_content_comment('tOboGo_CytoplasmicMicrotubule',s("Any","microtubule","in","the","cytoplasm","of","a","cell","."),3973754). assertion_content_comment('tOboGo_CytoplasmicMitoticChromosome',s("OBSOLETE",".","A","chromosome","found","in","the","cytoplasm","during","mitosis","."),4346206). assertion_content_comment('tOboGo_CytoplasmicMRNAProcessingBodyAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","RNA","molecules","to","form","a","cytoplasmic","mRNA","processing","body","."),4028202). assertion_content_comment('tOboGo_CytoplasmicMRNAProcessingBody',s("A","focus","in","the","cytoplasm","where","mRNAs","may","become","inactivated","by","decapping","or","some","other","mechanism",".","mRNA","processing","and","binding","proteins","are","localized","to","these","foci","."),4363224). assertion_content_comment('tOboGo_CytoplasmicNucleosome',s("A","complex","comprised","of","DNA","wound","around","a","multisubunit","core","and","associated","proteins",",","which","forms","the","primary","packing","unit","of","DNA","in","the","cytoplasm","into","higher","order","structures","."),3978470). 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assertion_content_comment('tOboGo_CytoplasmicPatternRecognitionReceptorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","pattern","recognition","receptor","(","PRR",")","located","in","the","cytoplasm",".","Such","receptors","bind","for","molecular","patterns","based","on","a","repeating","or","polymeric","structures",",","like","those","of","polysaccharides","or","peptidoglycans",",","which","are","sometimes","associated","with","potential","pathogens","."),4382469). assertion_content_comment('tOboGo_CytoplasmicReplicationFork',s("The","Y-shaped","region","of","a","cytoplasmic","replicating","DNA","molecule",",","resulting","from","the","separation","of","the","DNA","strands","and","in","which","the","synthesis","of","new","strands","takes","place",".","Also","includes","associated","protein","complexes","."),4094698). 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assertion_content_comment('tOboGo_CytoplasmicRNASurveillance',s("The","set","of","processes","involved","in","identifying","and","degrading","defective","or","aberrant","RNAs","within","the","cytoplasm","."),4167368). assertion_content_comment('tOboGo_CytoplasmicSCFUbiquitinLigaseComplex',s("A","ubiquitin","ligase","complex",",","located","in","the","cytoplasm",",","in","which","a","cullin","from","the","Cul1","subfamily","and","a","RING","domain","protein","form","the","catalytic","core",";","substrate","specificity","is","conferred","by","a","Skp1","adaptor","and","an","F-box","protein",".","SCF","complexes","are","involved","in","targeting","proteins","for","degradation","by","the","proteasome",".","The","best","characterized","complexes","are","those","from","yeast","and","mammals","(","with","core","subunits","named","Cdc53/Cul1",",","Rbx1/Hrt1/Roc1",")"),4318687). assertion_content_comment('tOboGo_CytoplasmicSequesteringOfCFTRProtein',s("The","selective","interaction","of","Cystic","Fibrosis","Transmembrane","conductance","Regulator","(","CFTR",")","protein","with","specific","molecules","in","the","cytoplasm",",","thereby","inhibiting","its","transport","to","the","cell","membrane","."),4318122). assertion_content_comment('tOboGo_CytoplasmicSequesteringOfProtein',s("The","selective","interaction","of","a","protein","with","specific","molecules","in","the","cytoplasm",",","thereby","inhibiting","its","transport","into","other","areas","of","the","cell","."),4016469). assertion_content_comment('tOboGo_CytoplasmicSequesteringOfTranscriptionFactor',s("The","selective","interaction","of","a","transcription","factor","with","specific","molecules","in","the","cytoplasm",",","thereby","inhibiting","its","translocation","into","the","nucleus","."),4016479). assertion_content_comment('tOboGo_CytoplasmicTransportNurseCellToOocyte',s("The","directed","movement","of","cytoplasmic","constituents","synthesized","in","the","nurse","cells","to","the","oocyte","."),4018674). assertion_content_comment('tOboGo_CytoplasmicTransport',s("The","directed","movement","of","substances","(","such","as","macromolecules",",","small","molecules",",","ions",")","into",",","out","of",",","or","within","the","cytoplasm","of","a","cell","."),4018670). assertion_content_comment('tOboGo_CytoplasmicTRNAImportIntoMitochondrion',s("The","directed","movement","of","cytoplasmic","tRNA","into","a","mitochondrion","."),4302629). assertion_content_comment('tOboGo_CytoplasmicUbiquitinLigaseComplex',s("A","ubiquitin","ligase","complex","found","in","the","cytoplasm","."),3978897). assertion_content_comment('tOboGo_CytoplasmicUSnRNPBody',s("A","ribonucleoprotein","complex","that","can","be","visualized","as","a","focus","in","the","cytoplasm",",","and","contains","uridine-rich","small","nuclear","ribonucleoproteins","(","U","snRNPs",")","and","essential","snRNP","assembly","factors",".","These","U","bodies","are","invariably","found","in","association","with","P","bodies","."),4165589). assertion_content_comment('tOboGo_CytoplasmicVesicleMembrane',s("The","lipid","bilayer","surrounding","a","cytoplasmic","vesicle","."),3989608). assertion_content_comment('tOboGo_CytoplasmicVesiclePart',s("Any","constituent","part","of","cytoplasmic","vesicle",",","a","vesicle","formed","of","membrane","or","protein",",","found","in","the","cytoplasm","of","a","cell","."),3979471). assertion_content_comment('tOboGo_CytoplasmicVesicle',s("A","vesicle","formed","of","membrane","or","protein",",","found","in","the","cytoplasm","of","a","cell","."),3979433). assertion_content_comment('tOboGo_CytoplasmOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","cytoplasm",".","The","cytoplasm","is","all","of","the","contents","of","a","cell","excluding","the","plasma","membrane","and","nucleus",",","but","including","other","subcellular","structures","."),4016938). assertion_content_comment('tOboGo_Cytoplasm',s("All","of","the","contents","of","a","cell","excluding","the","plasma","membrane","and","nucleus",",","but","including","other","subcellular","structures","."),3971407). assertion_content_comment('tOboGo_Cytoproct',s("Stable",",","specialized","structure","for","extrusion","of","waste","by","the","cell","into","the","surrounding","medium","."),4320210). assertion_content_comment('tOboGo_CytosineBinding',s("Interactiing","selectively","with","cytosine","."),4374098). assertion_content_comment('tOboGo_CytosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cytosine",",","4-amino-2-hydroxypyrimidine",",","a","pyrimidine","derivative","that","is","one","of","the","five","main","bases","found","in","nucleic","acids",";","it","occurs","widely","in","cytidine","derivatives","."),4348026). assertion_content_comment('tOboGo_CytosineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","cytosine",",","4-amino-2-hydroxypyrimidine",",","a","pyrimidine","derivative","that","is","one","of","the","five","main","bases","found","in","nucleic","acids",";","it","occurs","widely","in","cytidine","derivatives","."),4226757). assertion_content_comment('tOboGo_CytosineCytosineMispairBinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","a","C/C","mispair","."),4376818). assertion_content_comment('tOboGo_CytosineDeaminaseActivity',s("Catalysis","of","the","reaction",":","cytosine","+","H2O","=","uracil","+","NH3","."),4211705). assertion_content_comment('tOboGo_Cytosine_HydrogenIonSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","cytosine","(","out",")","+","H","+","(","out",")","=","cytosine","(","in",")","+","H","+","(","in",")"),4292699). assertion_content_comment('tOboGo_CytosineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","cytosine",",","4-amino-2-hydroxypyrimidine",",","a","pyrimidine","derivative","that","is","one","of","the","five","main","bases","found","in","nucleic","acids",";","it","occurs","widely","in","cytidine","derivatives","."),4226754). assertion_content_comment('tOboGo_CytosineThymineMispairBinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","a","C/T","mispair","."),4376794). assertion_content_comment('tOboGo_CytosineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","cytosine",",","4-amino-2-hydroxypyrimidine","from","one","side","of","a","membrane","to","the","other","."),4292695). assertion_content_comment('tOboGo_CytosineTransport',s("The","directed","movement","of","cytosine",",","4-amino-2-hydroxypyrimidine",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293846). assertion_content_comment('tOboGo_CytoskeletalAdaptorActivity',s("The","binding","activity","of","a","molecule","that","brings","together","a","cytoskeletal","protein","and","one","or","more","other","molecules",",","permitting","them","to","function","in","a","coordinated","way","."),4247094). assertion_content_comment('tOboGo_CytoskeletalAnchoringActivity',s("OBSOLETE",".","The","direct","or","indirect","linkage","of","cytoskeletal","filaments","to","the","plasma","membrane","."),4304468). assertion_content_comment('tOboGo_CytoskeletalAnchoringAtNuclearMembrane',s("The","process","in","which","cytoskeletal","filaments","are","directly","or","indirectly","linked","to","the","nuclear","membrane","."),4155515). assertion_content_comment('tOboGo_CytoskeletalAnchoringAtPlasmaMembrane',s("A","cytoskeleton","organization","process","that","directly","or","indirectly","links","cytoskeletal","filaments","to","the","plasma","membrane","."),4235390). assertion_content_comment('tOboGo_CytoskeletalCalyx',s("A","large","cytoskeletal","structure","located","at","the","posterior","end","of","the","perinuclear","theca","of","a","mammalian","sperm","head",".","The","nucleus","is","tightly","associated","with","the","calyx",",","which","contains","calicin","and","basic","cylicin","proteins","."),4065654). assertion_content_comment('tOboGo_CytoskeletalMatrixOrganizationAtActiveZone',s("The","assembly","and","arrangement","of","cytomatrix","proteins","to","form","complexes","in","the","cell","cortex","beneath","the","active","zone",",","i.e",".","just","beneath","the","presynaptic","plasma","membrane","."),4330161). assertion_content_comment('tOboGo_CytoskeletalPart',s("Any","constituent","part","of","the","cytoskeleton",",","a","cellular","scaffolding","or","skeleton","that","maintains","cell","shape",",","enables","some","cell","motion","(","using","structures","such","as","flagella","and","cilia",")",",","and","plays","important","roles","in","both","intra-cellular","transport","(","e.g",".","the","movement","of","vesicles","and","organelles",")","and","cellular","division",".","Includes","constituent","parts","of","intermediate","filaments",",","microfilaments",",","microtubules",",","and","the","microtrabecular","lattice","."),3971812). assertion_content_comment('tOboGo_CytoskeletalProteinBinding',s("Interacting","selectively","and","non-covalently","with","any","protein","component","of","any","cytoskeleton","(","actin",",","microtubule",",","or","intermediate","filament","cytoskeleton",")"),4178651). assertion_content_comment('tOboGo_CytoskeletalRearrangementInvolvedInPhagocytosisEngulfment',s("The","assembly","and","arrangement","of","cytoskeletal","structures","that","is","involved","in","the","internalization","of","bacteria",",","immune","complexes","and","other","particulate","matter","or","of","an","apoptotic","cell","by","phagocytosis","."),4108741). assertion_content_comment('tOboGo_CytoskeletalRegulatorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4252944). assertion_content_comment('tOboGo_CytoskeletalRegulatoryProteinBinding',s("Interacting","selectively","and","non-covalently","with","any","protein","involved","in","modulating","the","reorganization","of","the","cytoskeleton","."),4218635). assertion_content_comment('tOboGo_CytoskeletonOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","."),3969249). assertion_content_comment('tOboGo_CytoskeletonPolarizationInvolvedInGrowthPlateCartilageChondrocyteDivision',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","polarization","of","cytoskeletal","structures","in","a","growth","plate","cartilage","chondrocyte",".","This","process","results","in","the","oriented","division","of","the","cell","."),4004384). assertion_content_comment('tOboGo_Cytoskeleton',s("Any","of","the","various","filamentous","elements","that","form","the","internal","framework","of","cells",",","and","typically","remain","after","treatment","of","the","cells","with","mild","detergent","to","remove","membrane","constituents","and","soluble","components","of","the","cytoplasm",".","The","term","embraces","intermediate","filaments",",","microfilaments",",","microtubules",",","the","microtrabecular","lattice",",","and","other","structures","characterized","by","a","polymeric","filamentous","nature","and","long-range","order","within","the","cell",".","The","various","elements","of","the","cytoskeleton","not","only","serve","in","the","maintenance","of","cellular","shape","but","also","have","roles","in","other","cellular","functions",",","including","cellular","movement",",","cell","division",",","endocytosis",",","and","movement","of","organelles","."),3971810). assertion_content_comment('tOboGo_CytosolAlanylAminopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","an","N-terminal","amino","acid",",","preferentially","alanine",",","from","a","wide","range","of","peptides",",","amides","and","arylamides","."),4304547). assertion_content_comment('tOboGo_CytosolicArylHydrocarbonReceptorComplex',s("An","aryl","hydrocarbon","receptor","complex","found","in","the","cytosol",",","in","which","the","ligand-binding","subunit","AhR","is","not","bound","to","ligand",";","consists","of","AhR",",","two","molecules","of","HSP90",",","the","protein","kinase","c-Src",",","and","the","immunophilin","XAP2/AIP","."),4349495). assertion_content_comment('tOboGo_CytosolicCalciumIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","calcium","ions","within","the","cytosol","of","a","cell","or","between","the","cytosol","and","its","surroundings","."),4029675). assertion_content_comment('tOboGo_CytosolicCalciumIonTransport',s("The","directed","movement","of","calcium","ions","(","Ca2","+",")","into",",","out","of","or","within","the","cytosol","."),4029721). assertion_content_comment('tOboGo_CytosolicElectronTransferFlavoproteinComplex',s("A","protein","complex","located","in","the","cytosol","containing","flavin","adenine","dinucleotide","(","FAD",")","that",",","together","with","an","acyl-CoA","dehydrogenase",",","forms","a","system","that","oxidizes","an","acyl-CoA","molecule","and","reduces","ubiquinone","and","other","acceptors","."),4298809). assertion_content_comment('tOboGo_CytosolicIsocitrateDehydrogenaseComplexNAD',s("Cytosolic","complex","that","possesses","isocitrate","dehydrogenase","(","NAD","+",")","activity","."),4298833). assertion_content_comment('tOboGo_CytosolicLargeRibosomalSubunit',s("The","large","subunit","of","a","ribosome","located","in","the","cytosol","."),4053652). assertion_content_comment('tOboGo_CytosolicOxoglutarateDehydrogenaseComplex',s("A","cytosolic","complex","of","multiple","copies","of","three","enzymatic","components",":","oxoglutarate","dehydrogenase","(","lipoamide",")",";","EC",":","1.2.4.2","(","E1",")",",","dihydrolipoamide","S-succinyltransferase",";","EC",":","2.3.1.61","(","E2",")","and","dihydrolipoamide","dehydrogenase",";","EC",":","1.8.1.4","(","E3",")",";","catalyzes","the","overall","conversion","of","2-oxoglutarate","to","succinyl-CoA","and","carbon","dioxide","(","CO2",")"),4298798). assertion_content_comment('tOboGo_CytosolicPart',s("Any","constituent","part","of","cytosol",",","that","part","of","the","cytoplasm","that","does","not","contain","membranous","or","particulate","subcellular","components","."),4053633). assertion_content_comment('tOboGo_CytosolicPhospholipaseA2Activity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","phosphatidylcholine","+","H2O","=","1-acylglycerophosphocholine","+","a","fatty","acid","anion","."),4203081). assertion_content_comment('tOboGo_CytosolicProteasomeComplex',s("A","proteasome","complex","found","in","the","cytosol","of","a","cell","."),4060096). assertion_content_comment('tOboGo_CytosolicProteasomeCoreComplex',s("The","core","complex","of","a","proteasome","located","in","the","cytosol","of","a","cell","."),4060240). assertion_content_comment('tOboGo_CytosolicProteasomeRegulatoryParticleBaseSubcomplex',s("The","subcomplex","of","the","proteasome","regulatory","particle","that","directly","associates","with","the","proteasome","core","complex","located","in","the","cytosol","of","the","cell","."),4060109). assertion_content_comment('tOboGo_CytosolicProteasomeRegulatoryParticleLidSubcomplex',s("The","subcomplex","of","the","cytosolic","proteasome","regulatory","particle","that","forms","the","peripheral","lid",",","which","is","added","on","top","of","the","base","subcomplex","."),4060219). assertion_content_comment('tOboGo_CytosolicProteasomeRegulatoryParticle',s("A","multisubunit","complex","located","in","the","cytosol","of","a","cell",",","which","caps","one","or","both","ends","of","the","proteasome","core","complex",".","This","complex","recognizes",",","unfolds","ubiquitinated","proteins","and","translocates","them","to","the","proteasome","core","complex","."),4060098). assertion_content_comment('tOboGo_CytosolicPyruvateDehydrogenaseComplex',s("Complex","that","carries","out","the","oxidative","decarboxylation","of","pyruvate","to","form","acetyl-CoA",";","comprises","subunits","possessing","three","catalytic","activities",":","pyruvate","dehydrogenase","(","E1",")",",","dihydrolipoamide","S-acetyltransferase","(","E2",")",",","and","dihydrolipoamide","dehydrogenase","(","E3",")","Usually","contains","fewer","subunits","than","its","eukaryotic","counterpart",";","for","example",",","the","E",".","coli","complex","contains","12","E1","dimers",",","8","E2","trimers",",","and","6","E3","dimers","arranged","in","highly","symmetric","cubic","order","."),4298738). assertion_content_comment('tOboGo_CytosolicRibosomalRNA',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218393). assertion_content_comment('tOboGo_CytosolicRibosome',s("A","ribosome","located","in","the","cytosol","."),4053636). assertion_content_comment('tOboGo_CytosolicSmallRibosomalSubunit',s("The","small","subunit","of","a","ribosome","located","in","the","cytosol","."),4053670). assertion_content_comment('tOboGo_CytosolicTricarboxylicAcidCycleEnzymeComplex',s("Any","of","the","heteromeric","enzymes",",","located","in","the","cytosol",",","that","act","in","the","tricarboxylic","acid","(","TCA",")","cycle","."),4298770). assertion_content_comment('tOboGo_CytosolicTRNA',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218304). assertion_content_comment('tOboGo_CytosolicTRNAWobbleBaseThiouridylaseComplex',s("A","complex","of","two","proteins","involved","in","the","thiolation","of","U34","in","glutamate",",","lysine",",","and","glutamine","tRNAs","of","eukaryotes","."),4375347). assertion_content_comment('tOboGo_CytosolicTypeIIFattyAcidSynthaseComplex',s("OBSOLETE","A","fatty","acid","synthase","complex","in","which","each","polypeptide","chain","catalyzes","a","single","activity",",","located","in","the","cytosol","."),4319725). assertion_content_comment('tOboGo_CytosolNonspecificDipeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","dipeptides",",","preferentially","hydrophobic","dipeptides","including","prolyl","amino","acids","."),4312947). assertion_content_comment('tOboGo_CytosolPyruvateDehydrogenaseLipoamidePhosphataseComplex',s("A","cytosolic","complex","of","a","regulatory","and","catalytic","subunit","that","catalyzes","the","dephosphorylation","and","concomitant","reactivation","of","the","alpha","subunit","of","the","E1","component","of","the","pyruvate","dehydrogenase","complex","."),4298786). assertion_content_comment('tOboGo_Cytosol',s("The","part","of","the","cytoplasm","that","does","not","contain","organelles","but","which","does","contain","other","particulate","matter",",","such","as","protein","complexes","."),4053631). assertion_content_comment('tOboGo_CytosolToERTransport',s("The","directed","movement","of","substances","from","the","cytosol","to","the","endoplasmic","reticulum","of","a","cell","."),4361884). assertion_content_comment('tOboGo_Cytostome',s("Stable",",","specialized","structure","for","the","ingestion","of","food","by","the","cell","into","phagosomes","."),4320232). assertion_content_comment('tOboGo_CytotoxicTCellDegranulation',s("The","regulated","exocytosis","of","secretory","granules","containing","preformed","mediators","such","as","perforin","and","granzymes","by","a","cytotoxic","T","cell","."),4093629). assertion_content_comment('tOboGo_CytotoxicTCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","T","cell","acquires","specialized","features","of","a","cytotoxic","T","cell","."),4088418). assertion_content_comment('tOboGo_CytotoxinActivity',s("OBSOLETE",".","Acts","as","to","cause","injury","to","other","living","cells","."),4233676). assertion_content_comment('tOboGo_CZone',s("A","region","of","the","A","band","in","which","myosin-binding","protein","C","is","located","and","that","can","be","seen","by","electron","microscopy",".","This","is","a","functional","zone","that","also","includes","myosin","."),4039701). assertion_content_comment('tOboGo_D1DopamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","D1","dopamine","receptor","."),4322662). assertion_content_comment('tOboGo_D2DopamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","D2","dopamine","receptor","."),4322652). assertion_content_comment('tOboGo_D3DopamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","D3","dopamine","receptor","."),4322591). assertion_content_comment('tOboGo_D4DopamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","D4","dopamine","receptor","."),4322601). assertion_content_comment('tOboGo_D5DopamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","D5","dopamine","receptor","."),4322611). assertion_content_comment('tOboGo_DADPBinding',s("Interacting","selectively","and","non-covalently","with","dADP",",","deoxyadenosine","diphosphate","."),4331849). assertion_content_comment('tOboGo_DADPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dADP",",","deoxyadenosine","diphosphate","(","2","'","-deoxyadenosine","5","'","-diphosphate",")"),4227726). assertion_content_comment('tOboGo_DADPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dADP",",","deoxyadenosine","diphosphate","(","2","'","-deoxyadenosine","5","'","-diphosphate",")"),4348365). assertion_content_comment('tOboGo_DADPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dADP",",","deoxyadenosine","diphosphate","(","2","'","-deoxyadenosine","5","'","-diphosphate",")"),4227712). assertion_content_comment('tOboGo_DADPPhosphorylation',s("The","process","of","introducing","a","phosphate","group","into","dADP",",","deoxyadenosine","diphosphate",",","to","produce","dATP","."),4227715). assertion_content_comment('tOboGo_DamagedDNABinding',s("Interacting","selectively","and","non-covalently","with","damaged","DNA","."),4193485). assertion_content_comment('tOboGo_DAMPBinding',s("Interacting","selectively","and","non-covalently","with","dAMP",",","deoxyadenosine","monophosphate","."),4331867). assertion_content_comment('tOboGo_DAMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dAMP",",","deoxyadenosine","monophosphate","(","2","'","-deoxyadenosine","5","'","-phosphate",")"),4227857). assertion_content_comment('tOboGo_DAMPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dAMP",",","deoxyadenosine","monophosphate","(","2","'","-deoxyadenosine","5","'","-phosphate",")"),4348379). assertion_content_comment('tOboGo_DAMPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dAMP",",","deoxyadenosine","monophosphate","(","2","'","-deoxyadenosine","5","'","-phosphate",")"),4227854). assertion_content_comment('tOboGo_DASHComplex',s("A","large","protein","complex",",","containing","around","8-10","subunits","in","yeast",",","including","Duo1p",",","Dam1p",",","Dad1p","and","Ask1p",".","The","complex","forms","part","of","the","kinetochore",",","associates","with","microtubules","when","the","kinetochore","attaches","to","the","spindle",",","and","plays","a","role","in","spindle","attachment",",","chromosome","segregation","and","spindle","stability","."),4077235). assertion_content_comment('tOboGo_DATPBinding',s("Interacting","selectively","and","non-covalently","with","dATP",",","deoxyadenosine","triphosphate","."),4331858). assertion_content_comment('tOboGo_DATPBiosyntheticProcessFromADP',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dATP",",","deoxyadenosine","triphosphate","(","2","'","-deoxyadenosine","5","'","-triphosphate",")","from","other","compounds",",","including","ADP",",","adenosine","diphosphate","."),4227778). assertion_content_comment('tOboGo_DATPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dATP",",","deoxyadenosine","triphosphate","(","2","'","-deoxyadenosine","5","'","-triphosphate",")"),4227760). assertion_content_comment('tOboGo_DATPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dATP",",","deoxyadenosine","triphosphate","(","2","'","-deoxyadenosine","5","'","-triphosphate",")"),4348294). assertion_content_comment('tOboGo_DATPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dATP",",","deoxyadenosine","triphosphate","(","2","'","-deoxyadenosine","5","'","-triphosphate",")"),4227757). assertion_content_comment('tOboGo_DATPPyrophosphohydrolaseActivity',s("Catalysis","of","the","reaction",":","deoxy-ATP","+","H2O","=","dAMP","+","diphosphate","."),4250130). assertion_content_comment('tOboGo_DauerEntry',s("Entry","into","the","facultative","diapause","of","the","dauer","(","enduring",")","larval","stage","of","nematode","development","."),4094260). assertion_content_comment('tOboGo_DauerExit',s("Exit","from","the","facultative","diapause","of","the","dauer","(","enduring",")","larval","stage","of","nematode","development","."),4094220). assertion_content_comment('tOboGo_DauerLarvalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","dauer","larva","over","time",",","through","the","facultative","diapause","of","the","dauer","(","enduring",")","larval","stage",",","with","specialized","traits","adapted","for","dispersal","and","long-term","survival",",","with","elevated","stress","resistance","and","without","feeding","."),4094201). assertion_content_comment('tOboGo_DaunorubicinTransport',s("The","directed","movement","of","daunorubicin",",","an","anthracycline","antibiotic","produced","by","Streptomyces","coeruleorubidus","or","S",".","peucetius","and","used","as","an","antineoplastic","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4318666). assertion_content_comment('tOboGo_DBDDomainBinding',s("Interacting","selectively","and","non-covalently","with","the","DBD",",","DNA","binding","domain",",","of","a","protein",".","The","DNA","binding","domain","of","the","vitamin","D","receptor",",","one","of","a","family","of","receptors","with","the","DBD",",","is","split","into","three","regions",",","the","P",",","D","and","T","boxes",".","Residues","that","are","critical","for","target","sequence","selectivity","form","the","P-box",".","The","D-box","contains","residues","that","are","important","for","homodimerization","of","class","I","nuclear","receptors",".","The","T-box","is","essential","for","both","DNA-binding","and","transactivation","of","the","VDR",";","this","region","may","also","be","important","for","dimerization","with","RXR","for","class","II","nuclear","receptors","."),4277182). assertion_content_comment('tOboGo_DCDPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dCDP",",","deoxycytidine","5","'","-diphosphate","."),4223071). assertion_content_comment('tOboGo_DCDPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dCDP",",","deoxycytidine","5","'","-diphosphate","."),4223556). assertion_content_comment('tOboGo_DCDPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dCDP",",","deoxycytidine","5","'","-diphosphate","."),4223068). assertion_content_comment('tOboGo_DCMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dCMP",",","deoxycytidine","monophosphate","."),4225861). assertion_content_comment('tOboGo_DCMPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dCMP",",","deoxycytidine","monophosphate","."),4223405). assertion_content_comment('tOboGo_DCMPDeaminaseActivity',s("Catalysis","of","the","reaction",":","dCMP","+","H2O","=","dUMP","+","NH3","."),4211718). assertion_content_comment('tOboGo_DCMPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dCMP",",","deoxycytidine","monophosphate","."),4223402). assertion_content_comment('tOboGo_DCMPSalvage',s("Any","process","that","generates","dCMP",",","deoxycytidine","monophosphate","from","derivatives","of","it",",","without","de","novo","synthesis","."),4225867). assertion_content_comment('tOboGo_DCTCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","distal","convoluted","tubule","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4122980). assertion_content_comment('tOboGo_DCTCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","distal","convoluted","tubule","cells","of","the","kidney","as","it","progresses","from","its","formation","to","the","mature","state","."),4122969). assertion_content_comment('tOboGo_DCTCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","distal","convoluted","tubule","cell","."),4123051). assertion_content_comment('tOboGo_DCTPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dCTP",",","deoxycytidine","triphosphate","."),4222933). assertion_content_comment('tOboGo_DCTPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dCTP",",","deoxycytidine","triphosphate","."),4223637). assertion_content_comment('tOboGo_DCTPDeaminaseActivity',s("Catalysis","of","the","reaction",":","dCTP","+","H2O","=","dUTP","+","NH3","."),4250475). assertion_content_comment('tOboGo_DCTPDiphosphataseActivity',s("Catalysis","of","the","reaction",":","dCTP","+","H2O","=","dCMP","+","diphosphate","."),4374803). assertion_content_comment('tOboGo_DCTPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dCTP",",","deoxycytidine","triphosphate","."),4222930). assertion_content_comment('tOboGo_DDELSequenceBinding',s("Interacting","selectively","and","non-covalently","with","a","KDEL","sequence",",","the","C","terminus","tetrapeptide","sequence","Asp-Asp-Glu-Leu","found","in","proteins","that","are","to","be","retained","in","the","endoplasmic","reticulum","."),4307454). assertion_content_comment('tOboGo_DDTResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4245993). assertion_content_comment('tOboGo_DDTSusceptibilityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4304370). assertion_content_comment('tOboGo_DeacetylaseActivity',s("Catalysis","of","the","hydrolysis","of","an","acetyl","group","or","groups","from","a","substrate","molecule","."),4206218). assertion_content_comment('tOboGo_DeacetylipecosideSynthaseActivity',s("Catalysis","of","the","reaction",":","deacetylipecoside","+","H","(","2",")","O","=","dopamine","+","secologanin","."),4268199). assertion_content_comment('tOboGo_DeacetylisoipecosideSynthaseActivity',s("Catalysis","of","the","reaction",":","deacetylisoipecoside","+","H","(","2",")","O","=","dopamine","+","secologanin","."),4268188). assertion_content_comment('tOboGo_DeactivationOfRhodopsinMediatedSignaling',s("The","process","of","restoring","the","photoreceptor","cell","to","its","unexcited","state","after","termination","of","the","stimulus","(","photon",")"),4033776). assertion_content_comment('tOboGo_DeaminaseActivity',s("Catalysis","of","the","removal","of","an","amino","group","from","a","substrate",",","producing","ammonia","(","NH3",")"),4189720). assertion_content_comment('tOboGo_DeathDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","death","domain","of","a","protein",".","The","death","domain","(","DD",")","is","a","homotypic","protein","interaction","module","composed","of","a","bundle","of","six","alpha-helices",".","DD","bind","each","other","forming","oligomers",".","Some","DD-containing","proteins","are","involved","in","the","regulation","of","apoptosis","and","inflammation","through","their","activation","of","caspases","and","NF-kappaB","."),4174974). assertion_content_comment('tOboGo_DeathReceptorActivity',s("Combining","with","a","death","ligand","to","initiate","a","change","in","cell","activity","that","includes","competing","for","ligand","with","a","death","receptor",",","and","does","not","include","initiation","of","apoptosis",".","A","death","ligand","is","a","ligand","that","can","induce","apoptosis","when","bound","to","a","receptor","that","can","be","coupled","to","a","caspase","cascade","via","a","specific","cytoplasmic","domain","."),4213968). assertion_content_comment('tOboGo_DeathReceptorAdaptorProteinActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4215052). assertion_content_comment('tOboGo_DeathReceptorBinding',s("Interacting","selectively","and","non-covalently","with","any","member","of","the","death","receptor","(","DR",")","family",".","The","DR","family","falls","within","the","tumor","necrosis","factor","receptor","superfamily","and","is","characterized","by","a","cytoplasmic","region","of","~","80","residues","termed","the","death","domain","(","DD",")"),4214681). assertion_content_comment('tOboGo_DeathReceptorInteractingProteinActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4215064). assertion_content_comment('tOboGo_Death',s("A","permanent","cessation","of","all","vital","functions",":","the","end","of","life",";","can","be","applied","to","a","whole","organism","or","to","a","part","of","an","organism","."),3981303). assertion_content_comment('tOboGo_DebranchingEnzyme',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4221252). assertion_content_comment('tOboGo_DecanoyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","decanoyl","(","CH3-","[","CH2","]","8-CO-",")","group","to","an","acceptor","molecule","."),4355117). assertion_content_comment('tOboGo_DecapentaplegicReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","decapentaplegic","receptor","binding","to","one","of","its","physiological","ligands","."),4150403). assertion_content_comment('tOboGo_DecaprenylDiphosphateSynthaseComplex',s("A","complex","that","possesses","di-trans",",","poly-cis-decaprenylcistransferase","activity",";","involved","in","ubiquinone","biosynthesis","."),4055789). assertion_content_comment('tOboGo_Decidualization',s("The","cellular","and","vascular","changes","occurring","in","the","endometrium","of","the","pregnant","uterus","just","after","the","onset","of","blastocyst","implantation",".","This","process","involves","the","proliferation","and","differentiation","of","the","fibroblast-like","endometrial","stromal","cells","into","large",",","polyploid","decidual","cells","that","eventually","form","the","maternal","component","of","the","placenta","."),4099255). assertion_content_comment('tOboGo_DecoyDeathReceptorActivity',s("Combining","with","a","death","ligand","to","initiate","a","change","in","cell","activity","that","includes","coupling","to","caspase","cascades","that","induce","apoptosis","or","to","kinase","cascades","that","turn","on","gene","expression","through","NF-kappaB","and","AP-1",".","A","death","ligand","is","a","ligand","that","can","induce","apoptosis","when","bound","to","a","receptor","that","can","be","coupled","to","a","caspase","cascade","via","a","specific","cytoplasmic","domain","."),4215073). assertion_content_comment('tOboGo_DecylcitrateSynthaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","lauroyl-CoA","+","oxaloacetate","=","(","2S",",","3S",")","-2-hydroxytridecane-1",",","2",",","3-tricarboxylate","+","CoA","+","H","(","+",")"),4266040). assertion_content_comment('tOboGo_DecylhomocitrateSynthaseActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","H","(","2",")","O","+","lauroyl-CoA","=","(","3S",",","4S",")","-3-hydroxytetradecane-1",",","3",",","4-tricarboxylate","+","CoA","+","H","(","+",")"),4266027). assertion_content_comment('tOboGo_Dedifferentiation',s("The","process","in","which","a","specialized","structure","(","cell",",","tissue","or","organ",")","loses","structural","or","functional","features","that","characterize","it","in","the","mature","organism",",","or","some","other","relatively","stable","phase","of","the","organism","'","s","life","history",".","Under","certain","conditions",",","these","structures","can","revert","back","to","the","features","of","their","ancestors","."),4326391). assertion_content_comment('tOboGo_DeepFiber',s("Inward","projections","of","the","cytoskeletal","structures","of","the","oral","apparatus",",","which","form","a","fiber","that","extends","past","the","cytostome","into","the","cytoplasm","."),4055023). assertion_content_comment('tOboGo_DeepNuclearNeuronCellMigration',s("The","directed","movement","of","a","deep","nuclear","neuron","from","the","ventricular","zone","to","the","deep","hindbrain","nuclei","."),4047943). assertion_content_comment('tOboGo_DeepNuclearNeuronPrecursorProliferation',s("The","multiplication","or","reproduction","of","neuroblasts","that","will","give","rise","to","deep","nuclear","neurons","."),4048886). assertion_content_comment('tOboGo_DeethylatrazineMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","2","deethylatrazine","+","O2","=","2","CH3COCH3","+","2","deisopropyldeethylatrazine","."),4276739). assertion_content_comment('tOboGo_DefasciculationOfMotorNeuronAxon',s("Separation","of","a","motor","axon","away","from","a","bundle","of","axons","known","as","a","fascicle","."),4234666). assertion_content_comment('tOboGo_Defecation',s("The","expulsion","of","feces","from","the","rectum","."),4139985). assertion_content_comment('tOboGo_DefenseImmunityProteinActivity',s("OBSOLETE",".","Any","activity","that","plays","a","role","in","the","defense/immune","response","of","an","organism","against","infection","and","disease","."),4192936). assertion_content_comment('tOboGo_DefenseResponseByCalloseDepositionInCellWall',s("Any","process","in","which","callose","is","transported","to",",","and/or","maintained","in",",","the","cell","wall","during","the","defense","response",".","Callose","is","a","linear","1",",","3-beta-d-glucan","formed","from","UDP-glucose","and","is","found","in","certain","plant","cell","walls","."),4185415). assertion_content_comment('tOboGo_DefenseResponseByCalloseDeposition',s("Any","process","in","which","callose","is","transported","to",",","and/or","maintained","in",",","a","specific","location","during","the","defense","response",".","Callose","is","a","linear","1",",","3-beta-d-glucan","formed","from","UDP-glucose","and","is","found","in","certain","plant","cell","walls","."),4138588). assertion_content_comment('tOboGo_DefenseResponseByCellWallThickening',s("A","type","of","cell","wall","modification",",","in","which","the","cell","wall","is","reinforced","and","made","thicker",",","that","occurs","as","part","of","the","defense","response","of","an","organism","."),4185396). assertion_content_comment('tOboGo_DefenseResponseIncompatibleInteraction',s("A","response","of","a","plant","to","a","pathogenic","agent","that","prevents","the","occurrence","or","spread","of","disease","."),4022036). assertion_content_comment('tOboGo_DefenseResponse',s("Reactions",",","triggered","in","response","to","the","presence","of","a","foreign","body","or","the","occurrence","of","an","injury",",","which","result","in","restriction","of","damage","to","the","organism","attacked","or","prevention/recovery","from","the","infection","caused","by","the","attack","."),3982869). assertion_content_comment('tOboGo_DefenseResponseToBacteriumIncompatibleInteraction',s("A","response","of","an","organism","to","a","bacterium","that","prevents","the","occurrence","or","spread","of","disease","."),4262463). assertion_content_comment('tOboGo_DefenseResponseToBacterium',s("Reactions","triggered","in","response","to","the","presence","of","a","bacterium","that","act","to","protect","the","cell","or","organism","."),3997386). assertion_content_comment('tOboGo_DefenseResponseToFungusIncompatibleInteraction',s("A","response","of","an","organism","to","a","fungus","that","prevents","the","occurrence","or","spread","of","disease","."),4138540). assertion_content_comment('tOboGo_DefenseResponseToFungus',s("Reactions","triggered","in","response","to","the","presence","of","a","fungus","that","act","to","protect","the","cell","or","organism","."),3997478). assertion_content_comment('tOboGo_DefenseResponseToInsect',s("A","response","to","protect","an","organism","from","a","directly","detected","or","perceived","external","threat","from","an","insect","or","insects","to","that","organism","."),4138893). assertion_content_comment('tOboGo_DefenseResponseToNematode',s("A","response","to","protect","an","organism","from","a","directly","detected","or","perceived","external","threat","from","a","nematode","or","nematodes",",","which","results","in","restriction","of","damage","to","the","organism","attacked","or","prevention/recovery","from","the","infection","caused","by","the","attack","."),4376952). assertion_content_comment('tOboGo_DefenseResponseToOomycetes',s("Reactions","triggered","in","response","to","the","presence","of","oomycetes","that","act","to","protect","the","cell","or","organism","."),4377537). assertion_content_comment('tOboGo_DefenseResponseToParasiticPlant',s("Reactions","triggered","in","response","to","the","presence","of","a","parasitic","plant","that","act","to","protect","an","organism","."),4377794). assertion_content_comment('tOboGo_DefenseResponseToProtozoanIncompatibleInteraction',s("A","response","of","an","organism","to","a","protozoan","that","prevents","the","occurrence","or","spread","of","disease","."),4262446). assertion_content_comment('tOboGo_DefenseResponseToProtozoan',s("Reactions","triggered","in","response","to","the","presence","of","a","protozoan","that","act","to","protect","the","cell","or","organism","."),4262438). assertion_content_comment('tOboGo_DefenseResponseToTumorCell',s("Reactions","triggered","in","response","to","the","presence","of","a","tumor","cell","that","act","to","protect","the","cell","or","organism","."),4379530). assertion_content_comment('tOboGo_DefenseResponseToVirus',s("Reactions","triggered","in","response","to","the","presence","of","a","virus","that","act","to","protect","the","cell","or","organism","."),4101363). assertion_content_comment('tOboGo_DefinitiveErythrocyteDifferentiation',s("Erythrocyte","differentiation","which","occurs","as","part","of","the","process","of","definitive","hemopoiesis","."),4026985). assertion_content_comment('tOboGo_DefinitiveHemopoiesis',s("A","second","wave","of","blood","cell","production","that",",","in","vertebrates",",","generates","long-term","hemopoietic","stem","cells","that","continously","provide","erythroid",",","myeloid","and","lymphoid","lineages","throughout","adulthood","."),4026980). assertion_content_comment('tOboGo_Dehiscence',s("The","opening","of","an","anther",",","fruit","or","other","structure",",","which","permits","the","escape","of","reproductive","bodies","contained","within","it","."),4021441). assertion_content_comment('tOboGo_DehydroascorbicAcidTransporterActivity',s("Enables","the","directed","movement","of","dehydroascorbate",",","5-","(","1",",","2-dihydroxyethyl",")","furan-2",",","3",",","4","(","5H",")","-trione",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4338873). assertion_content_comment('tOboGo_DehydroascorbicAcidTransport',s("The","directed","movement","of","dehydroascorbate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Dehydroascorbate",",","5-","(","1",",","2-dihydroxyethyl",")","furan-2",",","3",",","4","(","5H",")","-trione",",","is","an","oxidized","form","of","vitamin","C","."),4178793). assertion_content_comment('tOboGo_DehydrodolichylDiphosphateSynthaseActivity',s("Catalysis","of","the","condensation","of","isopentenyl","diphosphate","and","farnesyl","diphosphate","in","the","cis-configuration","to","form","dehydrodolichyl","diphosphate","."),4299350). assertion_content_comment('tOboGo_DehydrogluconateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-D-gluconate","+","A","=","2",",","5-didehydro-D-gluconate","+","AH","(","2",")"),4374924). assertion_content_comment('tOboGo_DehydrogluconokinaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-D-gluconate","+","ATP","=","6-phospho-2-dehydro-D-gluconate","+","ADP","+","2","H","(","+",")"),4374828). assertion_content_comment('tOboGo_DeisopropylatrazineMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","2","deisopropylatrazine","+","O2","=","2","acetaldehyde","+","2","deisopropyldeethylatrazine","."),4276748). assertion_content_comment('tOboGo_DeisopropyldeethylatrazineHydrolaseActivity',s("Catalysis","of","the","reaction",":","deisopropyldeethylatrazine","+","H2O","=","2-chloro-4-hydroxy-6-amino-1",",","3",",","5-triazine","+","NH3","."),4274286). assertion_content_comment('tOboGo_DeisopropylhydroxyatrazineAminohydrolaseActivity',s("Catalysis","of","the","reaction",":","deisopropylhydroxyatrazine","+","H2O","=","NH3","+","2",",","4-dihydroxy-6-","(","N","'","-ethyl",")","amino-1",",","3",",","5-triazine","."),4274802). assertion_content_comment('tOboGo_DelaminationInvolvedInGastrulationWithMouthFormingSecond',s("The","splitting","or","migration","of","one","epithelial","sheet","into","two","involved","in","the","process","of","deuterostomic","gastrulation","."),4109521). 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assertion_content_comment('tOboGo_Delta1Complex',s("A","protein","complex","that","consists","of","homodimer","of","the","Notch","ligand","Delta1","."),4176317). assertion_content_comment('tOboGo_DeltaDNAPolymeraseComplex',s("A","multimeric","DNA","polymerase","enzyme","complex","which","differs","in","composition","amongst","species",";","in","humans","it","is","a","heterotetramer","of","four","subunits","of","approximately","125",",","50",",","68","and","12kDa",",","while","in","S",".","cerevisiae",",","it","has","three","different","subunits","which","form","a","heterotrimer",",","and","the","active","enzyme","is","a","dimer","of","this","heterotrimer",".","Functions","in","DNA","replication",",","mismatch","repair","and","excision","repair","."),4095193). assertion_content_comment('tOboGo_DemethylaseActivity',s("Catalysis","of","the","removal","of","a","methyl","group","from","a","substrate","."),4171537). assertion_content_comment('tOboGo_Demethylation',s("The","process","of","removing","one","or","more","methyl","groups","from","a","molecule","."),4171591). assertion_content_comment('tOboGo_DemethylmenaquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-demethylmenaquinone","+","S-adenosyl-L-methionine","=","menaquinone","+","S-adenosyl-L-homocysteine","."),4327955). assertion_content_comment('tOboGo_DenaturedProteinBinding',s("Interacting","selectively","and","non-covalently","with","denatured","proteins","."),4320036). assertion_content_comment('tOboGo_Dendriole',s("Small","dendrites","that","makes","up","a","brush","structure","found","as","the","terminal","specialization","of","a","dendrite","of","a","unipolar","brush","cell","(","UBC",")"),4288121). assertion_content_comment('tOboGo_DendriteCytoplasm',s("All","of","the","contents","of","a","dendrite",",","excluding","the","surrounding","plasma","membrane","."),4069508). assertion_content_comment('tOboGo_DendriteDevelopmentByRetrogradeExtension',s("The","progression","of","a","dendrite","over","time","by","the","attachment","of","a","part","of","the","neuron","to","an","anchor","and","the","subsequent","migration","of","the","cell","body","away","from","the","anchor","point","."),4004713). assertion_content_comment('tOboGo_DendriteDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","dendrite","over","time",",","from","its","formation","to","the","mature","structure",".","A","dendrite","is","a","freely","branching","protoplasmic","process","of","a","nerve","cell","."),4004711). assertion_content_comment('tOboGo_DendriteGuidance',s("The","process","in","which","the","migration","of","a","dendrite","is","directed","to","a","specific","target","site","in","response","to","a","combination","of","attractive","and","repulsive","cues","."),4131554). assertion_content_comment('tOboGo_DendriteMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","dendrite","."),4331721). assertion_content_comment('tOboGo_DendriteMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","dendrite","are","generated","and","organized",".","A","dendrite","is","a","freely","branching","protoplasmic","process","of","a","nerve","cell","."),4100952). assertion_content_comment('tOboGo_DendriteRegeneration',s("The","regrowth","of","dendrites","in","response","to","their","loss","or","damage","."),4318736). assertion_content_comment('tOboGo_Dendrite',s("A","neuron","projection","that","has","a","short",",","tapering",",","often","branched",",","morphology",",","receives","and","integrates","signals","from","other","neurons","or","from","sensory","stimuli",",","and","conducts","a","nerve","impulse","towards","the","axon","or","the","cell","body",".","In","most","neurons",",","the","impulse","is","conveyed","from","dendrites","to","axon","via","the","cell","body",",","but","in","some","types","of","unipolar","neuron",",","the","impulse","does","not","travel","via","the","cell","body","."),4067498). assertion_content_comment('tOboGo_DendriteTerminus',s("A","structure","at","the","distal","end","of","a","dendrite","adapted","to","carry","out","a","specific","function",",","e.g",".","dendriole","."),4097889). assertion_content_comment('tOboGo_DendriticBranch',s("A","dendrite","arising","from","another","dendrite","."),4096865). assertion_content_comment('tOboGo_DendriticCellAntigenProcessingAndPresentation',s("The","process","in","which","a","dendritic","cell","expresses","antigen","(","peptide","or","lipid",")","on","its","cell","surface","in","association","with","an","MHC","protein","complex","."),3993484). assertion_content_comment('tOboGo_DendriticCellChemotaxis',s("The","movement","of","a","dendritic","cell","in","response","to","an","external","stimulus","."),4144640). assertion_content_comment('tOboGo_DendriticCellCytokineProduction',s("Any","process","that","contributes","to","cytokine","production","by","a","dendritic","cell","."),3997141). assertion_content_comment('tOboGo_DendriticCellDendriteAssembly',s("Formation","of","dendrites",",","branched","cellular","projections","(","or","cytoplasmic","extension",")","that","are","extended","from","the","surface","of","a","dendritic","immune","cell",",","and","which","enable","the","cell","to","sample","luminal","pathogens","and","increase","the","surface","area","for","antigen","presentation","to","T","cells","."),4073974). assertion_content_comment('tOboGo_DendriticCellDifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","dendritic","cell",".","A","dendritic","cell","is","a","leukocyte","of","dendritic","lineage","specialized","in","the","uptake",",","processing",",","and","transport","of","antigens","to","lymph","nodes","for","the","purpose","of","stimulating","an","immune","response","via","T","cell","activation","."),4074056). assertion_content_comment('tOboGo_DendriticGrowthCone',s("The","migrating","motile","tip","of","a","growing","nerve","cell","dendrite","."),4288111). assertion_content_comment('tOboGo_DendriticShaft',s("Cylindric","portion","of","the","dendrite",",","directly","stemming","from","the","perikaryon",",","and","carrying","the","dendritic","spines","."),4093138). assertion_content_comment('tOboGo_DendriticSpineDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","dendritic","spine","over","time",",","from","its","formation","to","the","mature","structure",".","A","dendritic","spine","is","a","protrusion","from","a","dendrite","and","a","specialized","subcellular","compartment","involved","in","synaptic","transmission","."),4113086). assertion_content_comment('tOboGo_DendriticSpineHead',s("Distal","part","of","the","dendritic","spine",",","that","carries","the","post-synaptic","density","."),4096801). assertion_content_comment('tOboGo_DendriticSpineMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","dendritic","spine","."),4067511). assertion_content_comment('tOboGo_DendriticSpineMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","dendritic","spine","are","generated","and","organized",".","A","dendritic","spine","is","a","protrusion","from","a","dendrite","and","a","specialized","subcellular","compartment","involved","in","synaptic","transmission","."),4113088). assertion_content_comment('tOboGo_DendriticSpineNeck',s("Part","of","the","dendritic","spine","that","connects","the","dendritic","shaft","to","the","head","of","the","dendritic","spine","."),4096811). assertion_content_comment('tOboGo_DendriticSpine',s("Protrusion","from","a","dendrite",".","Spines","are","specialised","subcellular","compartments","involved","in","the","synaptic","transmission",".","They","are","linked","to","the","dendritic","shaft","by","a","restriction",".","Because","of","their","bulb","shape",",","they","function","as","a","biochemical","and","an","electrical","compartment",".","Spine","remodeling","is","though","to","be","involved","in","synaptic","plasticity","."),4067500). assertion_content_comment('tOboGo_DendriticTuft',s("The","terminal","specialization","found","in","some","types","of","dendrites","which","consists","of","numerous","small","terminal","branches",",","giving","the","dendrite","a","tufted","appearance","."),4288140). assertion_content_comment('tOboGo_DenitrificationPathway',s("The","reduction","of","nitrate","to","dinitrogen","by","four","reactions",";","each","intermediate","is","transformed","to","the","next","lower","oxidation","state",";","also","part","of","cellular","bioenergetics",";","the","nitrogen","compounds","can","serve","as","terminal","acceptors","for","electron","transport","phosphorylation","in","place","of","oxygen","."),4240585). assertion_content_comment('tOboGo_DeNovoActinFilamentNucleation',s("The","actin","nucleation","process","in","which","actin","monomers","combine","in","the","absence","of","any","existing","actin","filaments",";","elongation","of","the","actin","oligomer","formed","by","nucleation","leads","to","the","formation","of","an","unbranched","filament","."),4180051). assertion_content_comment('tOboGo_DeNovoAMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","adenosine","monophosphate","(","AMP",")","from","inosine","5","'","-monophosphate","(","IMP",")"),4288271). assertion_content_comment('tOboGo_DeNovoCotranslationalProteinFolding',s("The","process","of","assisting","in","the","correct","noncovalent","assembly","of","the","ribosome-bound","nascent","chains","of","a","multidomain","protein","whilst","other","parts","of","the","protein","are","still","being","translated","."),4287088). assertion_content_comment('tOboGo_DeNovoCTPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","cytidine","5","'","-triphosphate","(","CTP",")","from","simpler","components","."),4288208). assertion_content_comment('tOboGo_DeNovoIMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","IMP",",","inosine","monophosphate",",","by","the","stepwise","assembly","of","a","purine","ring","on","ribose","5-phosphate","."),4226942). assertion_content_comment('tOboGo_DeNovoNADBiosyntheticProcessFromAspartate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","adenine","dinucleotide","(","NAD",")",",","beginning","with","the","synthesis","of","aspartate","from","simpler","precursors",";","biosynthesis","may","be","of","either","the","oxidized","form",",","NAD",",","or","the","reduced","form",",","NADH","."),4353770). assertion_content_comment('tOboGo_DeNovoNADBiosyntheticProcessFromTryptophan',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","adenine","dinucleotide","(","NAD",")",",","beginning","with","the","synthesis","of","tryptophan","from","simpler","precursors",";","biosynthesis","may","be","of","either","the","oxidized","form",",","NAD",",","or","the","reduced","form",",","NADH","."),4355443). assertion_content_comment('tOboGo_DeNovoNADBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","nicotinamide","adenine","dinucleotide","(","NAD",")",",","beginning","with","the","synthesis","of","tryptophan","or","aspartate","from","simpler","precursors",";","biosynthesis","may","be","of","either","the","oxidized","form",",","NAD",",","or","the","reduced","form",",","NADH","."),4353768). assertion_content_comment('tOboGo_DeNovoPosttranslationalProteinFolding',s("The","process","of","assisting","in","the","correct","noncovalent","folding","of","newly","formed","polypeptides","or","folding","intermediates","of","polypeptides","that","have","exited","the","ribosome","and/or","have","been","stabilized","and","transferred","by","other","chaperone","proteins",".","This","process","could","involve","several","cycles","of","ATP","hydrolysis","."),4287101). assertion_content_comment('tOboGo_DeNovoProteinFolding',s("The","process","of","assisting","in","the","folding","of","a","nascent","peptide","chain","into","its","correct","tertiary","structure","."),4224044). assertion_content_comment('tOboGo_DeNovoPyrimidineBaseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pyrimidine","bases",",","1",",","3-diazine",",","organic","nitrogenous","bases",",","beginning","with","the","synthesis","of","a","pyrimidine","ring","from","simpler","precursors","."),4226730). assertion_content_comment('tOboGo_DeNovoUMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UMP",",","uridine","monophosphate",",","starting","with","the","synthesis","of","(","S",")","-dihydroorotate","from","bicarbonate",";","UMP","biosynthesis","may","either","occur","via","reduction","by","quinone",",","NAD","(","+",")","or","oxygen","."),4288237). assertion_content_comment('tOboGo_DenseCoreGranuleBiogenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","dense","core","granule",".","Includes","biosynthesis","of","constituent","macromolecules",",","and","those","macromolecular","modifications","that","are","involved","in","synthesis","or","assembly","of","the","dense","core","granule","."),4156175). assertion_content_comment('tOboGo_DenseCoreGranuleLocalization',s("Any","process","in","which","a","dense","core","granule","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell","."),4054009). assertion_content_comment('tOboGo_DenseCoreGranuleMembrane',s("The","lipid","bilayer","surrounding","a","dense","core","granule","."),4055044). assertion_content_comment('tOboGo_DenseCoreGranuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","dense","core","granule",".","A","dense","core","granule","is","a","secretory","organelle","found","in","endocrine","cells","."),4156184). assertion_content_comment('tOboGo_DenseCoreGranule',s("Electron-dense","organelle","with","a","granular","internal","matrix",";","contains","proteins","destined","to","be","secreted","."),4055033). assertion_content_comment('tOboGo_DenseFibrillarComponent',s("A","structure","found","in","the","nucleolus",",","which","contains","newly","synthesized","preribosomal","RNA","(","pre-rRNA",")","and","a","collection","of","proteins","."),4384077). assertion_content_comment('tOboGo_DenseNuclearBody',s("A","location","in","the","host","cell","nucleus","where","viral","proteins","colocalize","late","in","infection","prior","to","the","onset","of","viral","DNA","synthesis",".","More","than","one","site","can","be","present","simultaneously","."),4358032). assertion_content_comment('tOboGo_DentateGyrusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","dentate","gyrus","over","time",",","from","its","formation","to","the","mature","structure",".","The","dentate","gyrus","is","one","of","two","interlocking","gyri","of","the","hippocampus",".","It","contains","granule","cells",",","which","project","to","the","pyramidal","cells","and","interneurons","of","the","CA3","region","of","the","ammon","gyrus","."),4041167). assertion_content_comment('tOboGo_DentateGyrusMossyFiber',s("Distinctive",",","unmyelinated","axons","produced","by","granule","cells","."),4287841). assertion_content_comment('tOboGo_DentateNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","dentate","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042576). assertion_content_comment('tOboGo_DentineSecretion',s("The","regulated","release","by","odontoblasts","of","the","extracellular","matrix","constituents",",","including","collagen",",","that","form","the","basis","of","dentine","."),4131415). assertion_content_comment('tOboGo_DeoxyadenosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","deoxyadenosine",",","2-deoxyribosyladenine",",","one","of","the","four","major","nucleosides","of","DNA","."),4348011). assertion_content_comment('tOboGo_DeoxyadenosineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","deoxyadenosine",",","2-deoxyribosyladenine",",","one","of","the","four","major","nucleosides","of","DNA","."),4228027). assertion_content_comment('tOboGo_DeoxyadenosineDeaminaseActivity',s("Catalysis","of","the","reaction",":","deoxyadenosine","+","H2O","=","deoxyinosine","+","NH3","."),4228048). assertion_content_comment('tOboGo_DeoxyadenosineDeaminaseReaction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228052). assertion_content_comment('tOboGo_DeoxyadenosineKinaseActivity',s("Catalysis","of","the","reaction",":","2","'","-deoxyadenosine","+","ATP","=","ADP","+","dAMP","+","2","H","(","+",")"),4211816). assertion_content_comment('tOboGo_DeoxyadenosineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","deoxyadenosine",",","2-deoxyribosyladenine",",","one","of","the","four","major","nucleosides","of","DNA","."),4228023). assertion_content_comment('tOboGo_DeoxyAdenylateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","dAMP","=","ADP","+","dADP","."),4371566). assertion_content_comment('tOboGo_DeoxycytidineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","deoxycytidine",",","2-deoxyribosylcytosine",",","one","of","the","four","major","nucleosides","of","DNA","."),4226041). assertion_content_comment('tOboGo_DeoxycytidineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","deoxycytidine",",","2-deoxyribosylcytosine",",","one","of","the","four","major","nucleosides","of","DNA","."),4226498). assertion_content_comment('tOboGo_DeoxycytidineDeaminaseActivity',s("Catalysis","of","the","reaction",":","deoxycytidine","+","H2O","=","deoxyuridine","+","NH3","."),4374863). assertion_content_comment('tOboGo_DeoxycytidineKinaseActivity',s("Catalysis","of","the","reaction",":","NTP","+","deoxycytidine","=","NDP","+","CMP","."),4211829). assertion_content_comment('tOboGo_DeoxycytidineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","deoxycytidine",",","2-deoxyribosylcytosine",",","one","of","the","four","major","nucleosides","of","DNA","."),4226037). assertion_content_comment('tOboGo_DeoxycytidineSalvage',s("Any","process","that","generates","deoxycytidine",",","2-deoxyribosylcytosine",",","from","derivatives","of","it",",","without","de","novo","synthesis","."),4226047). assertion_content_comment('tOboGo_DeoxycytidylTransferaseActivity',s("Catalysis","of","the","insertion","of","a","dCMP","residue","opposite","a","template","abasic","site","in","DNA","."),4267520). assertion_content_comment('tOboGo_DeoxyguanosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","deoxyguanosine",",","a","nucleoside","consisting","of","the","base","guanine","and","the","sugar","deoxyribose","."),4313366). assertion_content_comment('tOboGo_DeoxyguanosineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","deoxyguanosine",",","a","nucleoside","consisting","of","the","base","guanine","and","the","sugar","deoxyribose","."),4227689). assertion_content_comment('tOboGo_DeoxyguanosineKinaseActivity',s("Catalysis","of","the","reaction",":","2","'","-deoxyguanosine","+","ATP","=","ADP","+","dGMP","+","2","H","(","+",")"),4211845). 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assertion_content_comment('tOboGo_DeoxyhypusineSynthaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","[","eIF5A-precursor","]","-lysine","+","spermidine","=","[","eIF5A-precursor","]","-deoxyhypusine","+","propane-1",",","3-diamine","."),4211009). assertion_content_comment('tOboGo_DeoxyinosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","deoxyinosine",",","hypoxanthine","deoxyriboside","."),4227386). assertion_content_comment('tOboGo_DeoxyinosineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","deoxyinosine",",","hypoxanthine","deoxyriboside","."),4227933). assertion_content_comment('tOboGo_DeoxyinosineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","deoxyinosine",",","hypoxanthine","deoxyriboside","."),4227382). assertion_content_comment('tOboGo_DeoxyinosineSalvage',s("Any","process","that","generates","deoxyinosine","from","derivatives","of","it",",","without","de","novo","synthesis","."),4227392). assertion_content_comment('tOboGo_DeoxynucleosideKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","2","'","-deoxynucleoside","=","ADP","+","2","'","-deoxynucleoside","5","'","-phosphate","."),4202150). assertion_content_comment('tOboGo_DeoxynucleotideTransmembraneTransporterActivity',s("Catalyzes","transport","of","all","four","deoxy","(","d",")","NDPs",",","and",",","less","efficiently",",","the","corresponding","dNTPs",",","in","exchange","for","dNDPs",",","ADP",",","or","ATP","."),4311695). assertion_content_comment('tOboGo_DeoxynucleotideTransport',s("The","directed","movement","of","a","deoxynucleotide",",","a","deoxyribonucleoside","in","ester","linkage","to","phosphate",",","commonly","at","the","5","'","position","of","deoxyribose",",","into",",","out","of","or","within","a","cell","."),4312207). assertion_content_comment('tOboGo_DeoxyribodipyrimidineEndonucleosidaseActivity',s("Catalysis","of","the","cleavage","of","the","N-glycosidic","bond","between","the","5","'","-pyrimidine","residue","in","cyclobutadipyrimidine","(","in","DNA",")","and","the","corresponding","deoxy-D-ribose","residue","."),4344489). assertion_content_comment('tOboGo_DeoxyribonucleaseActivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","deoxyribonucleic","acid","."),4183294). assertion_content_comment('tOboGo_DeoxyribonucleaseIActivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","DNA","to","5","'","-phosphodinucleotide","and","5","'","-phosphooligonucleotide","end","products","."),4204810). assertion_content_comment('tOboGo_DeoxyribonucleaseIIActivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","DNA","to","3","'","-phosphodinucleotide","and","3","'","-phosphooligonucleotide","end","products","."),4204943). assertion_content_comment('tOboGo_DeoxyribonucleaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","deoxyribonuclease","."),4161267). assertion_content_comment('tOboGo_DeoxyribonucleasePyrimidineDimerActivity',s("Catalysis","of","the","endonucleolytic","cleavage","near","pyrimidine","dimers","to","products","with","5","'","-phosphate","."),4344023). assertion_content_comment('tOboGo_DeoxyribonucleaseVActivity',s("Catalysis","of","the","endonucleolytic","cleavage","at","apurinic","or","apyrimidinic","sites","to","products","with","a","5","'","-phosphate","."),4325862). assertion_content_comment('tOboGo_DeoxyribonucleosideBinding',s("Interacting","selectively","and","non-covalently","with","a","deoxyribonucleoside",",","a","compound","consisting","of","a","purine","or","pyrimidine","nitrogenous","base","linked","to","deoxyribose","."),4331328). assertion_content_comment('tOboGo_DeoxyribonucleosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","one","of","a","family","of","organic","molecules","consisting","of","a","purine","or","pyrimidine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4225993). assertion_content_comment('tOboGo_DeoxyribonucleosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","one","of","a","family","of","organic","molecules","consisting","of","a","purine","or","pyrimidine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4226414). assertion_content_comment('tOboGo_DeoxyribonucleosideDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","deoxyribonucleoside","diphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223032). assertion_content_comment('tOboGo_DeoxyribonucleosideDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","deoxyribonucleoside","diphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223258). assertion_content_comment('tOboGo_DeoxyribonucleosideDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","deoxyribonucleoside","diphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","diphosphate","on","the","sugar","."),4223028). assertion_content_comment('tOboGo_DeoxyribonucleosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","one","of","a","family","of","organic","molecules","consisting","of","a","purine","or","pyrimidine","base","covalently","bonded","to","a","sugar","deoxyribose","(","a","deoxyribonucleoside",")"),4225989). assertion_content_comment('tOboGo_DeoxyribonucleosideMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","deoxyribonucleoside","monophosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4225591). assertion_content_comment('tOboGo_DeoxyribonucleosideMonophosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","deoxyribonucleoside","monophosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4223368). assertion_content_comment('tOboGo_DeoxyribonucleosideMonophosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","deoxyribonucleoside","monophosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","phosphate","on","the","sugar","."),4223364). assertion_content_comment('tOboGo_DeoxyribonucleosideTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222840). assertion_content_comment('tOboGo_DeoxyribonucleosideTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4223624). assertion_content_comment('tOboGo_DeoxyribonucleosideTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","deoxyribonucleoside","triphosphate",",","a","compound","consisting","of","a","nucleobase","linked","to","a","deoxyribose","sugar","esterified","with","triphosphate","on","the","sugar","."),4222821). assertion_content_comment('tOboGo_DeoxyribonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","deoxyribonucleotide",",","any","compound","consisting","of","a","deoxyribonucleoside","that","is","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","deoxyribose","moiety","."),4331297). assertion_content_comment('tOboGo_DeoxyribonucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","deoxyribonucleotide",",","a","compound","consisting","of","deoxyribonucleoside","(","a","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222834). assertion_content_comment('tOboGo_DeoxyribonucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","deoxyribonucleotide",",","a","compound","consisting","of","deoxyribonucleoside","(","a","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4223253). assertion_content_comment('tOboGo_DeoxyribonucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","deoxyribonucleotide",",","a","compound","consisting","of","deoxyribonucleoside","(","a","base","linked","to","a","deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222818). assertion_content_comment('tOboGo_DeoxyribosePhosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","deoxyribose","phosphate",",","the","phosphorylated","sugar","2-deoxy-erythro-pentose","."),4225357). assertion_content_comment('tOboGo_DeoxyribosePhosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","deoxyribose","phosphate",",","the","phosphorylated","sugar","2-deoxy-erythro-pentose","."),4225413). assertion_content_comment('tOboGo_DeoxyribosePhosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","deoxyribose","phosphate",",","the","phosphorylated","sugar","2-deoxy-erythro-pentose","."),4225339). assertion_content_comment('tOboGo_DeoxysarpagineHydroxylaseActivity',s("Catalysis","of","the","reaction",":","10-deoxysarpagine","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","H","(","2",")","O","+","NADP","(","+",")","+","sarpagine","."),4342196). assertion_content_comment('tOboGo_DeoxyuridineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","deoxyuridine",",","2-deoxyribosyluracil",",","one","of","the","four","major","nucleosides","of","DNA","."),4347996). assertion_content_comment('tOboGo_DeoxyuridineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","deoxyuridine",",","2-deoxyribosyluracil",",","one","of","the","four","major","nucleosides","of","DNA","."),4226441). assertion_content_comment('tOboGo_DeoxyuridineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","deoxyuridine",",","2-deoxyribosyluracil",",","one","of","the","four","major","nucleosides","of","DNA","."),4226393). assertion_content_comment('tOboGo_DeoxyuridinePhosphorylaseActivity',s("Catalysis","of","the","reaction",":","deoxyuridine","+","phosphate","=","uracil","+","deoxy-D-ribose","1-phosphate","."),4376454). assertion_content_comment('tOboGo_Dephosphorylation',s("The","process","of","removing","one","or","more","phosphoric","(","ester","or","anhydride",")","residues","from","a","molecule","."),4011001). assertion_content_comment('tOboGo_DepsipeptideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","depsipeptides",",","a","linear","or","cyclic","compound","composed","of","both","amino","acids","and","hydroxy","acids","in","peptide","and","ester","bonds","respectively","."),4275857). assertion_content_comment('tOboGo_DepsipeptideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","depsipeptides",",","a","linear","or","cyclic","compound","composed","of","both","amino","acids","and","hydroxy","acids","in","peptide","and","ester","bonds","respectively","."),4275872). assertion_content_comment('tOboGo_DepsipeptideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","depsipeptides",",","a","linear","or","cyclic","compound","composed","of","both","amino","acids","and","hydroxy","acids","in","peptide","and","ester","bonds","respectively","."),4275854). assertion_content_comment('tOboGo_Depurination',s("The","disruption","of","the","bond","between","the","sugar","in","the","backbone","and","the","A","or","G","base",",","causing","the","base","to","be","removed","and","leaving","a","depurinated","sugar","."),4300496). assertion_content_comment('tOboGo_Depyrimidination',s("The","disruption","of","the","bond","between","the","sugar","in","the","backbone","and","the","C","or","T","base",",","causing","the","base","to","be","removed","and","leaving","a","depyrimidinated","sugar","."),4300508). assertion_content_comment('tOboGo_DermatanSulfateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dermatan","sulfate",",","any","glycosaminoglycan","with","repeats","consisting","of","beta-","(","1",",","4",")","-linked","L-iduronyl-beta-","(","1",",","3",")","-N-acetyl-D-galactosamine","4-sulfate","units","."),4047186). assertion_content_comment('tOboGo_DermatanSulfateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dermatan","sulfate",",","any","of","a","group","of","glycosaminoglycans","with","repeats","consisting","of","beta-","(","1",",","4",")","-linked","L-iduronyl-beta-","(","1",",","3",")","-N-acetyl-D-galactosamine","4-sulfate","units","."),4311525). assertion_content_comment('tOboGo_DermatanSulfateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dermatan","sulfate",",","any","of","a","group","of","glycosaminoglycans","with","repeats","consisting","of","beta-","(","1",",","4",")","-linked","L-iduronyl-beta-","(","1",",","3",")","-N-acetyl-D-galactosamine","4-sulfate","units",".","They","are","important","components","of","ground","substance","or","intercellular","cement","of","skin","and","some","connective","tissues","."),4047158). assertion_content_comment('tOboGo_DermatanSulfateProteoglycanBiosyntheticProcessPolysaccharideChainBiosyntheticProcess',s("The","elongation","of","dermatan","sulfate","proteoglycan","chains","by","alternate","addition","of","N-acetylhexosamine","and","GlcUA","residues","to","the","GAG-protein","linkage","region","tetrasaccharide","of","dermatan","sulfate","."),4101834). assertion_content_comment('tOboGo_DermatanSulfateProteoglycanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dermatan","sulfate","proteoglycan",",","any","glycoprotein","whose","glycosaminoglycan","units","are","dermatan","sulfate","(","chondroitin","sulfate","B",")","Dermatan","sulfate","is","a","glycosaminoglycan","with","repeats","consisting","of","beta-","(","1",",","4",")","-linked","L-iduronyl-beta-","(","1",",","3",")","-N-acetyl-D-galactosamine","4-sulfate","units","."),4047116). assertion_content_comment('tOboGo_DermatanSulfateProteoglycanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dermatan","sulfate","proteoglycan",",","any","glycoprotein","whose","glycosaminoglycan","units","are","dermatan","sulfate","(","chondroitin","sulfate","B",")","Dermatan","sulfate","is","a","glycosaminoglycan","with","repeats","consisting","of","beta-","(","1",",","4",")","-linked","L-iduronyl-beta-","(","1",",","3",")","-N-acetyl-D-galactosamine","4-sulfate","units","."),4047109). assertion_content_comment('tOboGo_DermatomeDevelopment',s("The","progression","of","the","dermatome","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","dermatome","is","the","portion","of","a","somite","that","will","form","skin","."),4113425). assertion_content_comment('tOboGo_DescendingThinLimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","descending","thin","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","descending","thin","limb","is","a","part","of","the","loop","of","Henle","situated","just","after","the","proximal","straight","tubule","(","S3",")","It","extends","to","the","tip","of","the","loop","of","Henle","."),4123774). assertion_content_comment('tOboGo_Desmin',s("OBSOLETE",".","A","type","of","intermediate","filament","."),4299897). assertion_content_comment('tOboGo_DesmosomeAssembly',s("A","cellular","process","that","results","in","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","desmosome",".","A","desmosome","is","a","patch-like","intercellular","junctions","found","in","vertebrate","tissues",",","consisting","of","parallel","zones","of","two","cell","membranes",",","separated","by","an","space","of","25-35","nm",",","and","having","dense","fibrillar","plaques","in","the","subjacent","cytoplasm","."),4375275). assertion_content_comment('tOboGo_DesmosomeMaintenance',s("The","maintenance","of","a","desmosome",".","A","desmosome","is","a","patch-like","intercellular","junctions","found","in","vertebrate","tissues",",","consisting","of","parallel","zones","of","two","cell","membranes",",","separated","by","an","interspace","of","25-35","nm",",","and","having","dense","fibrillar","plaques","in","the","subjacent","cytoplasm","."),4375959). assertion_content_comment('tOboGo_Desmosome',s("A","cell-cell","junction","in","which",":","on","the","cytoplasmic","surface","of","each","interacting","plasma","membrane","is","a","dense","plaque","composed","of","a","mixture","of","intracellular","anchor","proteins",";","a","bundle","of","keratin","intermediate","filaments","is","attached","to","the","surface","of","each","plaque",";","transmembrane","adhesion","proteins","of","the","cadherin","family","bind","to","the","plaques","and","interact","through","their","extracellular","domains","to","hold","the","adjacent","membranes","together","by","a","Ca2","+","-dependent","mechanism","."),4306981). assertion_content_comment('tOboGo_DesulfoglucosinolateSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phospho-5","'","-adenylyl","sulfate","+","desulfoglucotropeolin","=","adenosine","3","'",",","5","'","-diphosphate","+","glucotropeolin","+","H","(","+",")"),4182728). assertion_content_comment('tOboGo_DetectionOfAbioticStimulus',s("The","series","of","events","in","which","an","(","non-living",")","abiotic","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3987337). assertion_content_comment('tOboGo_DetectionOfAbscisicAcidStimulus',s("The","series","of","events","in","which","an","abscisic","acid","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4260504). assertion_content_comment('tOboGo_DetectionOfActivity',s("The","series","of","events","in","which","an","activity","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4320821). assertion_content_comment('tOboGo_DetectionOfAuxinStimulus',s("The","series","of","events","in","which","an","auxin","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4260515). assertion_content_comment('tOboGo_DetectionOfBacterialLipopeptide',s("The","series","of","events","in","which","a","bacterial","lipopeptide","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4173278). assertion_content_comment('tOboGo_DetectionOfBacterialLipoprotein',s("The","series","of","events","in","which","a","bacterial","lipoprotein","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Bacterial","lipoproteins","are","lipoproteins","characterized","by","the","presence","of","conserved","sequence","motifs","called","pathogen-associated","molecular","patterns","(","PAMPs",")"),4078679). assertion_content_comment('tOboGo_DetectionOfBacterium',s("The","series","of","events","in","which","a","stimulus","from","a","bacterium","is","received","and","converted","into","a","molecular","signal","."),4078642). assertion_content_comment('tOboGo_DetectionOfBioticStimulus',s("The","series","of","events","in","which","a","biotic","stimulus",",","one","caused","or","produced","by","a","living","organism",",","is","received","and","converted","into","a","molecular","signal","."),4078638). assertion_content_comment('tOboGo_DetectionOfBrassinosteroidStimulus',s("The","series","of","events","in","which","a","brassinosteroid","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4260493). assertion_content_comment('tOboGo_DetectionOfCalciumIon',s("The","series","of","events","in","which","a","calcium","ion","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4218589). 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assertion_content_comment('tOboGo_DetectionOfCarbonDioxide',s("The","series","of","events","in","which","a","carbon","dioxide","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3991279). assertion_content_comment('tOboGo_DetectionOfCellDensityByContactStimulusInvolvedInContactInhibition',s("The","series","of","events","in","which","information","about","the","density","of","cells","in","a","population","is","received","by","direct","cell-cell","contact","and","is","converted","into","a","molecular","signal",",","resulting","in","the","cessation","of","cell","growth","or","proliferation","."),4116139). assertion_content_comment('tOboGo_DetectionOfCellDensityByContactStimulus',s("The","series","of","events","in","which","information","about","the","density","of","cells","in","a","population","is","received","by","direct","cell-cell","contact","and","is","converted","into","a","molecular","signal","."),4116136). 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assertion_content_comment('tOboGo_DetectionOfChemicalStimulusInvolvedInSensoryPerceptionOfUmamiTaste',s("The","series","of","events","required","for","a","umami","taste","stimulus","to","be","received","and","converted","to","a","molecular","signal",".","Umami","taste","is","the","savory","taste","of","meats","and","other","foods","that","are","rich","in","glutamates","."),4098498). assertion_content_comment('tOboGo_DetectionOfChemicalStimulusInvolvedInSensoryPerception',s("The","series","of","events","in","which","a","sensory","chemical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3981469). assertion_content_comment('tOboGo_DetectionOfChemicalStimulus',s("The","series","of","events","in","which","a","chemical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3981447). assertion_content_comment('tOboGo_DetectionOfCytokininStimulus',s("The","series","of","events","in","which","a","cytokinin","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4260526). assertion_content_comment('tOboGo_DetectionOfDiacylBacterialLipopeptide',s("The","series","of","events","in","which","a","diacylated","bacterial","lipopeptide","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Diacylated","bacterial","lipoproteins","are","lipopeptides","of","bacterial","origin","containing","a","nonprotein","moiety","consisting","of","two","acyl","groups","."),4313252). assertion_content_comment('tOboGo_DetectionOfDietaryExcess',s("The","neurological","process","in","which","the","brain","senses","excessive","caloric","intake","."),3990956). assertion_content_comment('tOboGo_DetectionOfDisaccharideStimulus',s("The","series","of","events","in","which","a","stimulus","from","a","disaccharide","is","received","and","converted","into","a","molecular","signal","."),4260443). assertion_content_comment('tOboGo_DetectionOfDNADamageStimulusInvolvedInDNADamageCheckpoint',s("The","series","of","events","in","which","information","about","damage","to","DNA","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","DNA","damage","checkpoint","."),4128131). assertion_content_comment('tOboGo_DetectionOfDNADamageStimulusInvolvedInG2MTransitionDNADamageCheckpoint',s("The","series","of","events","in","which","information","about","damage","to","DNA","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","G2/M","transition","DNA","damage","checkpoint","."),4128196). assertion_content_comment('tOboGo_DetectionOfDNADamageStimulusInvolvedInMitoticCellCycleG1STransitionDNADamageCheckpoint',s("The","series","of","events","in","which","information","about","damage","to","DNA","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","cell","cycle","G1/S","transition","DNA","damage","checkpoint","."),4128138). assertion_content_comment('tOboGo_DetectionOfDNADamageStimulusInvolvedInMitoticG2MTransitionDNADamageCheckpoint',s("The","series","of","events","in","which","information","about","damage","to","DNA","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","G2/M","transition","DNA","damage","checkpoint","."),4128203). assertion_content_comment('tOboGo_DetectionOfElectricalStimulusInvolvedInElectroception',s("The","series","of","events","that","contribute","to","electroception","in","which","a","sensory","electrical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100681). assertion_content_comment('tOboGo_DetectionOfElectricalStimulusInvolvedInMagnetoreception',s("The","series","of","events","that","contribute","to","magnetoception","in","which","a","sensory","electrical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","The","stimulus","is","in","the","form","of","an","induced","electric","field","resulting","from","movement","in","a","magnetic","field","."),4100348). assertion_content_comment('tOboGo_DetectionOfElectricalStimulusInvolvedInRegulationOfMuscleAdaptation',s("The","series","of","events","by","which","an","electrical","stimulus","is","received","and","converted","into","a","molecular","signal",".","This","occurs","as","part","of","the","regulation","of","muscle","adaptation","."),4321057). assertion_content_comment('tOboGo_DetectionOfElectricalStimulusInvolvedInSensoryPerceptionOfPain',s("The","series","of","events","that","contribute","to","the","perception","of","pain","in","which","a","sensory","electrical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100431). assertion_content_comment('tOboGo_DetectionOfElectricalStimulusInvolvedInSensoryPerception',s("The","series","of","events","in","which","a","sensory","electrical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100339). assertion_content_comment('tOboGo_DetectionOfElectricalStimulus',s("The","series","of","events","by","which","an","electrical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100336). assertion_content_comment('tOboGo_DetectionOfEndogenousStimulus',s("The","series","of","events","in","which","an","endogenous","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4003263). assertion_content_comment('tOboGo_DetectionOfEndoplasmicReticulumOverloading',s("The","series","of","events","in","which","a","stimulus","generated","by","the","accumulation","of","normal","or","misfolded","proteins","in","the","endoplasmic","reticulum","is","received","and","converted","into","a","molecular","signal","."),4377356). assertion_content_comment('tOboGo_DetectionOfEthyleneStimulus',s("The","series","of","events","in","which","an","ethylene","(","ethene",")","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4260469). assertion_content_comment('tOboGo_DetectionOfExternalStimulus',s("The","series","of","events","in","which","an","external","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3987324). assertion_content_comment('tOboGo_DetectionOfFolicAcid',s("The","series","of","events","in","which","a","folic","acid","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4319616). assertion_content_comment('tOboGo_DetectionOfFungus',s("The","series","of","events","in","which","a","stimulus","from","a","fungus","is","received","and","converted","into","a","molecular","signal","."),4261341). assertion_content_comment('tOboGo_DetectionOfGibberellicAcidStimulus',s("The","series","of","events","in","which","a","gibberellic","acid","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4260482). assertion_content_comment('tOboGo_DetectionOfGlucocorticoidHormoneStimulus',s("The","series","of","events","by","which","a","glucocorticoid","hormone","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Glucocorticoids","are","hormonal","C21","corticosteroids","synthesized","from","cholesterol","with","the","ability","to","bind","with","the","cortisol","receptor","and","trigger","similar","effects",".","Glucocorticoids","act","primarily","on","carbohydrate","and","protein","metabolism",",","and","have","anti-inflammatory","effects","."),4286526). assertion_content_comment('tOboGo_DetectionOfGlucose',s("The","series","of","events","in","which","a","glucose","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4284192). assertion_content_comment('tOboGo_DetectionOfGlutamine',s("The","series","of","events","in","which","a","glutamine","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4334285). assertion_content_comment('tOboGo_DetectionOfGravity',s("The","series","of","events","in","which","a","gravitational","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4131517). assertion_content_comment('tOboGo_DetectionOfHexoseStimulus',s("The","series","of","events","in","which","a","stimulus","from","a","hexose","is","received","and","converted","into","a","molecular","signal","."),4260424). assertion_content_comment('tOboGo_DetectionOfHormoneStimulus',s("The","series","of","events","in","which","a","hormone","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4260465). assertion_content_comment('tOboGo_DetectionOfHydrogenIon',s("The","series","of","events","in","which","a","hydrogen","ion","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3998814). assertion_content_comment('tOboGo_DetectionOfHypoxia',s("The","series","of","events","in","which","a","stimulus","indicating","lowered","oxygen","tension","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Hypoxia",",","defined","as","a","decline","in","O2","levels","below","normoxic","levels","of","20.8","-","20.95","%",",","results","in","metabolic","adaptation","at","both","the","cellular","and","organismal","level","."),3998887). assertion_content_comment('tOboGo_DetectionOfHypoxicConditionsInBloodByAorticBodyChemoreceptorSignaling',s("The","process","in","which","information","about","a","lack","of","oxygen","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","the","aortic","bodies","."),3999173). assertion_content_comment('tOboGo_DetectionOfHypoxicConditionsInBloodByCarotidBodyChemoreceptorSignaling',s("The","process","in","which","information","about","a","lack","of","oxygen","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","the","carotid","bodies","."),3999208). assertion_content_comment('tOboGo_DetectionOfHypoxicConditionsInBloodByChemoreceptorSignaling',s("The","process","in","which","information","about","a","lack","of","oxygen","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","the","carotid","bodies","and","the","aortic","bodies","."),3991648). assertion_content_comment('tOboGo_DetectionOfInactivity',s("The","series","of","events","in","which","a","inactivity","stimulus","is","received","by","a","cell","or","organism","and","converted","into","a","molecular","signal","."),4320859). assertion_content_comment('tOboGo_DetectionOfIncreasedCarbonDioxideByAorticBodyChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","carbon","dioxide","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","an","aortic","body","."),3999230). assertion_content_comment('tOboGo_DetectionOfIncreasedCarbonDioxideByCarotidBodyChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","carbon","dioxide","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","a","carotid","body","."),3999219). assertion_content_comment('tOboGo_DetectionOfIncreasedCarbonDioxideByChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","carbon","dioxide","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","the","carotid","bodies","and","the","aortic","bodies","."),3998902). assertion_content_comment('tOboGo_DetectionOfInjuryInvolvedInRegulationOfMuscleAdaptation',s("The","series","of","events","by","which","an","injury","stimulus","is","received","and","converted","into","a","molecular","signal",".","This","occurs","as","part","of","the","regulation","of","muscle","adaptation","."),4321001). assertion_content_comment('tOboGo_DetectionOfInsect',s("The","series","of","events","in","which","a","stimulus","from","an","insect","is","received","and","converted","into","a","molecular","signal","."),4261285). assertion_content_comment('tOboGo_DetectionOfJasmonicAcidStimulus',s("The","series","of","events","in","which","a","jasmonic","acid","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Series","of","events","required","for","a","jasmonic","acid","stimulus","to","be","detected","and","converted","to","a","signal","molecule","."),4262710). assertion_content_comment('tOboGo_DetectionOfLightStimulusInvolvedInMagnetoreception',s("The","series","of","events","involved","in","magnetoception","in","which","a","light","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Downstream","processing","of","the","light","information","in","addition","to","other","sensory","data","allows","organisms","to","perceive","the","orientation","of","a","magnetic","field","."),4119338). assertion_content_comment('tOboGo_DetectionOfLightStimulusInvolvedInSensoryPerception',s("The","series","of","events","in","which","a","sensory","light","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4020938). assertion_content_comment('tOboGo_DetectionOfLightStimulusInvolvedInVisualPerception',s("The","series","of","events","involved","in","visual","perception","in","which","a","sensory","light","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4020959). assertion_content_comment('tOboGo_DetectionOfLightStimulus',s("The","series","of","events","in","which","a","light","stimulus","(","in","the","form","of","photons",")","is","received","and","converted","into","a","molecular","signal","."),4020889). assertion_content_comment('tOboGo_DetectionOfLipopolysaccharide',s("The","series","of","events","in","which","a","lipopolysaccharide","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Lipopolysaccharide","is","a","major","component","of","the","cell","wall","of","gram-negative","bacteria","."),4334674). assertion_content_comment('tOboGo_DetectionOfLipoteichoicAcid',s("The","series","of","events","in","which","a","lipoteichoic","acid","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",";","lipoteichoic","acid","is","a","major","component","of","the","cell","wall","of","gram-positive","bacteria","and","typically","consists","of","a","chain","of","glycerol-phosphate","repeating","units","linked","to","a","glycolipid","anchor","."),4173543). assertion_content_comment('tOboGo_DetectionOfMaltoseStimulus',s("The","series","of","events","in","which","a","maltose","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4360045). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInEcholocation',s("The","series","of","events","involved","in","echolocation","in","which","a","sensory","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","The","stimulus","is","in","the","form","of","a","reflected","sound","wave","(","an","echo",")",",","which","the","organism","uses","to","determine","the","distance","to","the","object","that","reflected","the","sound","wave","."),4100375). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInEquilibrioception',s("The","series","of","events","involved","in","equilibrioception","in","which","a","sensory","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","During","equilibrioception",",","mechanical","stimuli","may","be","in","the","form","of","input","from","pressure","receptors","or","from","the","labyrinth","system","of","the","inner","ears","."),4100557). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInMagnetoreception',s("The","series","of","events","involved","in","magnetoception","in","which","a","sensory","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","The","stimulus","is","in","the","form","of","torque","on","particles","such","as","magnetite","which","respond","to","a","magnetic","field","."),4100404). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInSensoryPerceptionOfGravity',s("The","series","of","events","involved","in","the","perception","of","gravity","in","which","a","sensory","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4131522). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInSensoryPerceptionOfPain',s("The","series","of","events","involved","in","the","perception","of","pain","in","which","a","sensory","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100447). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInSensoryPerceptionOfSound',s("The","series","of","events","involved","in","the","perception","of","sound","vibration",".","The","vibration","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100186). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInSensoryPerceptionOfTouch',s("The","series","of","events","involved","in","the","perception","of","touch","in","which","a","sensory","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100520). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInSensoryPerceptionOfWind',s("The","series","of","events","involved","in","the","perception","of","wind","in","which","a","sensory","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4128696). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulusInvolvedInSensoryPerception',s("The","series","of","events","in","which","a","sensory","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100177). assertion_content_comment('tOboGo_DetectionOfMechanicalStimulus',s("The","series","of","events","by","which","a","mechanical","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3987354). assertion_content_comment('tOboGo_DetectionOfMisfoldedProtein',s("The","series","of","events","in","which","a","misfolded","protein","stimulus","is","received","and","converted","into","a","molecular","signal","."),4377458). assertion_content_comment('tOboGo_DetectionOfMoleculeOfBacterialOrigin',s("The","series","of","events","in","which","a","stimulus","from","a","molecule","of","bacterial","origin","is","received","and","converted","into","a","molecular","signal","."),4078663). assertion_content_comment('tOboGo_DetectionOfMoleculeOfFungalOrigin',s("The","series","of","events","in","which","a","stimulus","from","a","molecule","of","fungal","origin","is","received","and","converted","into","a","molecular","signal","."),4334698). assertion_content_comment('tOboGo_DetectionOfMoleculeOfOomycetesOrigin',s("The","series","of","events","in","which","a","stimulus","from","a","molecule","of","oomycetes","origin","is","received","and","converted","into","a","molecular","signal","."),4334686). assertion_content_comment('tOboGo_DetectionOfMonosaccharideStimulus',s("The","series","of","events","in","which","a","stimulus","from","a","monosaccharide","is","received","and","converted","into","a","molecular","signal","."),4260421). assertion_content_comment('tOboGo_DetectionOfMuramylDipeptide',s("The","series","of","events","in","which","a","muramyl","dipeptide","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Muramyl","dipeptide","is","derived","from","peptidoglycan","."),4334664). assertion_content_comment('tOboGo_DetectionOfMuscleActivityInvolvedInRegulationOfMuscleAdaptation',s("The","series","of","events","by","which","a","muscle","activity","stimulus","is","received","and","converted","into","a","molecular","signal",".","This","occurs","as","part","of","the","regulation","of","muscle","adaptation","."),4320910). assertion_content_comment('tOboGo_DetectionOfMuscleActivity',s("The","series","of","events","in","which","a","muscle","activity","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4320840). assertion_content_comment('tOboGo_DetectionOfMuscleInactivityInvolvedInRegulationOfMuscleAdaptation',s("The","series","of","events","in","which","a","muscle","inactivity","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","This","occurs","as","part","of","the","regulation","of","muscle","adaptation","."),4321012). assertion_content_comment('tOboGo_DetectionOfMuscleInactivity',s("The","series","of","events","in","which","a","muscle","inactivity","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4320969). assertion_content_comment('tOboGo_DetectionOfNematode',s("The","series","of","events","in","which","a","stimulus","from","a","nematode","is","received","and","converted","into","a","molecular","signal","."),4261273). assertion_content_comment('tOboGo_DetectionOfNodalFlow',s("The","series","of","events","by","which","an","endogenous","stimulus","is","received","by","a","cilium","on","a","cell","and","converted","to","a","molecular","signal","contributing","to","left/right","asymmetry","."),4003267). assertion_content_comment('tOboGo_DetectionOfNuclear_CytoplasmicRatio',s("The","process","in","which","the","size","of","the","nucleus","with","respect","to","its","cytoplasm","is","sensed","by","a","cell","."),4034324). assertion_content_comment('tOboGo_DetectionOfNutrient',s("The","series","of","events","in","which","a","nutrient","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4261449). assertion_content_comment('tOboGo_DetectionOfOomycetes',s("The","series","of","events","in","which","a","stimulus","from","an","oomycetes","is","received","and","converted","into","a","molecular","signal","."),4377480). assertion_content_comment('tOboGo_DetectionOfOrganicSubstance',s("The","series","of","events","in","which","an","organic","substance","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4170265). assertion_content_comment('tOboGo_DetectionOfOsmoticStimulus',s("The","series","of","events","in","which","a","stimulus","indicating","an","increase","or","decrease","in","the","concentration","of","solutes","outside","the","organism","or","cell","is","received","and","converted","into","a","molecular","signal","."),4325693). assertion_content_comment('tOboGo_DetectionOfOxidativeStress',s("The","series","of","events","in","which","a","stimulus","indicating","oxidative","stress","is","received","and","converted","into","a","molecular","signal","."),4177787). assertion_content_comment('tOboGo_DetectionOfOxygen',s("The","series","of","events","in","which","an","oxygen","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3998885). assertion_content_comment('tOboGo_DetectionOfParasiticFungus',s("The","series","of","events","in","which","a","stimulus","from","a","parasitic","fungus","(","a","fungus","which","spends","all","or","part","of","its","life","in","or","on","another","organism","from","which","it","obtains","nourishment","and/or","protection",")","is","received","and","converted","into","a","molecular","signal","."),4303441). assertion_content_comment('tOboGo_DetectionOfParasiticPlant',s("The","series","of","events","in","which","a","stimulus","from","a","parasitic","plant","is","received","and","converted","into","a","molecular","signal","."),4377815). assertion_content_comment('tOboGo_DetectionOfPeptidoglycan',s("The","series","of","events","in","which","a","peptidoglycan","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Peptidoglycan","is","a","bacterial","cell","wall","macromolecule","."),4334654). assertion_content_comment('tOboGo_DetectionOfPHByAorticBodyChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","hydrogen","ions","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","an","aortic","body","."),3999184). assertion_content_comment('tOboGo_DetectionOfPHByCarotidBodyChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","hydrogen","ions","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","a","carotid","body","."),3999307). assertion_content_comment('tOboGo_DetectionOfPHByChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","hydrogen","ions","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","the","carotid","bodies","and","the","aortic","bodies","."),3998817). assertion_content_comment('tOboGo_DetectionOfPheromone',s("The","series","of","events","in","which","a","pheromone","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4326382). assertion_content_comment('tOboGo_DetectionOfPhosphateIon',s("The","series","of","events","in","which","a","phosphate","ion","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4335523). assertion_content_comment('tOboGo_DetectionOfProtozoan',s("The","series","of","events","in","which","a","stimulus","from","a","protozoan","is","received","and","converted","into","a","molecular","signal","."),4361326). assertion_content_comment('tOboGo_DetectionOfRedoxState',s("The","series","of","events","in","which","a","chemical","stimulus","indicating","redox","state","is","received","and","converted","into","a","molecular","signal",".","Redox","state","refers","to","the","balance","of","oxidized","versus","reduced","forms","of","electron","donors","and","acceptors","in","an","organelle",",","cell","or","organ",";","plastoquinone",",","glutathione","(","GSH/GSSG",")",",","and","nicotinamide","nucleotides","(","NAD","+","/NADH","and","NADP","+","/NADPH",")","are","among","the","most","important","."),4280319). assertion_content_comment('tOboGo_DetectionOfReducedOxygenByAorticBodyChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","oxygen","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","an","aortic","body","."),3999296). assertion_content_comment('tOboGo_DetectionOfReducedOxygenByCarotidBodyChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","oxygen","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","a","carotid","body","."),3999285). assertion_content_comment('tOboGo_DetectionOfReducedOxygenByChemoreceptorSignaling',s("The","process","in","which","information","about","the","levels","of","oxygen","are","received","and","are","converted","to","a","molecular","signal","by","chemoreceptors","in","the","carotid","bodies","and","the","aortic","bodies","."),3998891). assertion_content_comment('tOboGo_DetectionOfRenalBloodFlow',s("The","process","in","which","the","juxtaglomerular","cells","of","the","kidneys","receive","information","about","the","amount","of","blood","flowing","through","the","arterioles","and","converts","the","information","to","a","molecular","signal","."),3991454). assertion_content_comment('tOboGo_DetectionOfSalicylicAcidStimulus',s("The","series","of","events","in","which","a","salicylic","acid","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4262698). assertion_content_comment('tOboGo_DetectionOfSteroidHormoneStimulus',s("The","series","of","events","by","which","a","steroid","hormone","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4286524). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInCellCycleCheckpoint',s("The","series","of","events","in","which","information","about","a","biological","process","or","quality","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","cell","cycle","checkpoint","."),4126766). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInCellShapeCheckpoint',s("The","series","of","events","in","which","information","about","aspects","of","cell","polarity","control","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","cell","shape","checkpoint","."),4127582). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInCellSizeControlCheckpoint',s("The","series","of","events","in","which","information","about","cell","size","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","cell","size","control","checkpoint","."),4127479). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInCytokinesisCheckpoint',s("The","series","of","events","in","which","information","about","the","formation","and","integrity","of","cytokinetic","structures",",","such","as","the","contractile","ring",",","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","cytokinesis","checkpoint","."),4126945). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInDNAIntegrityCheckpoint',s("The","series","of","events","in","which","information","about","changes","in","DNA","structure","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","DNA","integrity","checkpoint","."),4127022). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInDNAReplicationCheckpoint',s("The","series","of","events","in","which","information","about","whether","DNA","replication","is","complete","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","DNA","replication","checkpoint","."),4127886). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInG1STransitionCheckpoint',s("The","series","of","events","in","which","information","about","a","biological","process","or","quality","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","G1/S","transition","checkpoint","."),4126968). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInG2MTransitionCheckpoint',s("The","series","of","events","in","which","information","about","a","biological","process","or","quality","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","G2/M","transition","checkpoint","."),4126840). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInG2MTransitionSizeControlCheckpoint',s("The","series","of","events","in","which","information","about","cell","size","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","G2/M","transition","size","control","checkpoint","."),4127750). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMeioticCellCycleCheckpoint',s("The","series","of","events","in","which","information","about","a","biological","process","or","quality","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","meiotic","cell","cycle","checkpoint","."),4126772). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMeioticDNAReplicationCheckpoint',s("The","series","of","events","in","which","information","about","whether","DNA","replication","is","complete","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","meiotic","DNA","replication","checkpoint","."),4128087). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMeioticRecombinationCheckpoint',s("The","series","of","events","in","which","information","about","whether","recombination","is","complete","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","meiotic","recombination","checkpoint","."),4127619). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMeioticSpindleAssemblyCheckpoint',s("The","series","of","events","in","which","information","about","whether","spindle","is","correctly","assembled","and","chromosomes","are","attached","to","the","spindle","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","meiotic","spindle","assembly","checkpoint","."),4127606). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticCellCycleCheckpoint',s("The","series","of","events","in","which","information","about","a","biological","process","or","quality","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","cell","cycle","checkpoint","."),4126887). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticCellCycleG1SCheckpoint',s("The","series","of","events","in","which","information","about","a","biological","process","or","quality","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","cell","cycle","G1/S","checkpoint","."),4127444). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticCellCycleG1STransitionSizeControlCheckpoint',s("The","series","of","events","in","which","information","about","cell","size","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","cell","cycle","G1/S","transition","size","control","checkpoint","."),4127980). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticCellCycleSpindleAssemblyCheckpoint',s("The","series","of","events","in","which","information","about","whether","the","spindle","is","correctly","assembled",",","and","chromosomes","are","attached","to","the","spindle",",","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","cell","cycle","spindle","assembly","checkpoint","."),4127421). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticCellCycleSpindleCheckpoint',s("The","series","of","events","in","which","information","about","whether","the","spindle","is","correctly","assembled","and","oriented",",","and","chromosomes","are","attached","to","the","spindle",",","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","cell","cycle","spindle","checkpoint","."),4127364). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticCellCycleSpindleOrientationCheckpoint',s("The","series","of","events","in","which","information","about","whether","the","spindle","is","correctly","oriented","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","cell","cycle","spindle","orientation","checkpoint","."),4127370). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticDNAReplicationCheckpoint',s("The","series","of","events","in","which","information","about","whether","DNA","replication","is","complete","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","DNA","replication","checkpoint","."),4127892). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticG2MTransitionCheckpoint',s("The","series","of","events","in","which","information","about","a","biological","process","or","quality","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","G2/M","checkpoint","."),4127675). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInMitoticG2MTransitionDecatenationCheckpoint',s("The","series","of","events","in","which","information","about","whether","sister","chromatids","are","sufficiently","separated","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","mitotic","G2/M","decatenation","checkpoint","."),4127681). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInSensoryPerception',s("The","series","of","events","involved","in","sensory","perception","in","which","a","sensory","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),3981462). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInSeptinCheckpoint',s("The","series","of","events","in","which","information","about","the","formation","and","integrity","of","the","septin","ring","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","septin","checkpoint","."),4128303). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInSpindleAssemblyCheckpoint',s("The","series","of","events","in","which","information","about","spindle","assembly","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","spindle","assembly","checkpoint","."),4127274). assertion_content_comment('tOboGo_DetectionOfStimulusInvolvedInSpindleCheckpoint',s("The","series","of","events","in","which","information","about","the","assembly",",","orientation","or","integrity","of","the","spindle","is","received","and","converted","into","a","molecular","signal",",","contributing","to","a","spindle","checkpoint","."),4127268). assertion_content_comment('tOboGo_DetectionOfStimulus',s("The","series","of","events","in","which","a","stimulus","is","received","by","a","cell","or","organism","and","converted","into","a","molecular","signal","."),3981442). assertion_content_comment('tOboGo_DetectionOfSucroseStimulus',s("The","series","of","events","in","which","a","sucrose","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4260446). assertion_content_comment('tOboGo_DetectionOfSymbiont',s("The","series","of","events","in","which","a","stimulus","from","a","symbiont","(","an","organism","living","in","close","physical","association","with","an","organism","of","a","different","species",")","is","received","and","converted","into","a","molecular","signal",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4261308). assertion_content_comment('tOboGo_DetectionOfSymbioticBacterium',s("The","series","of","events","in","which","a","stimulus","from","a","symbiotic","bacterium",",","a","bacterium","living","in","close","physical","association","with","another","organism",",","is","received","and","converted","into","a","molecular","signal","."),4261360). assertion_content_comment('tOboGo_DetectionOfSymbioticFungus',s("The","series","of","events","in","which","a","stimulus","from","a","symbiotic","fungus",",","a","fungus","living","in","close","physical","association","with","another","organism",",","is","received","and","converted","into","a","molecular","signal","."),4261346). assertion_content_comment('tOboGo_DetectionOfTemperatureStimulusInvolvedInSensoryPerceptionOfPain',s("The","series","of","events","involved","in","the","perception","of","pain","in","which","a","sensory","temperature","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100698). assertion_content_comment('tOboGo_DetectionOfTemperatureStimulusInvolvedInSensoryPerception',s("The","series","of","events","in","which","a","sensory","temperature","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100614). assertion_content_comment('tOboGo_DetectionOfTemperatureStimulusInvolvedInThermoception',s("The","series","of","events","v","thermoception","in","which","a","sensory","temperature","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal","."),4100631). assertion_content_comment('tOboGo_DetectionOfTemperatureStimulus',s("The","series","of","events","in","which","a","temperature","stimulus","(","hot","or","cold",")","is","received","and","converted","into","a","molecular","signal","."),4100607). assertion_content_comment('tOboGo_DetectionOfTriacylBacterialLipopeptide',s("The","series","of","events","in","which","a","triacylated","bacterial","lipoprotein","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Triacylated","bacterial","lipoproteins","are","lipopeptides","of","bacterial","origin","containing","a","nonprotein","moiety","consisting","of","three","acyl","groups","."),4313213). assertion_content_comment('tOboGo_DetectionOfTumorCell',s("The","series","of","events","in","which","a","stimulus","from","a","tumor","cell","is","received","and","converted","into","a","molecular","signal","."),4379474). assertion_content_comment('tOboGo_DetectionOfUnfoldedProtein',s("The","series","of","events","in","which","an","unfolded","protein","stimulus","is","received","and","converted","into","a","molecular","signal","."),4377346). assertion_content_comment('tOboGo_DetectionOfUV',s("The","series","of","events","in","which","an","ultraviolet","radiation","(","UV","light",")","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","Ultraviolet","radiation","is","electromagnetic","radiation","with","a","wavelength","in","the","range","of","10","to","380","nanometers","."),4234903). assertion_content_comment('tOboGo_DetectionOfVirus',s("The","series","of","events","in","which","a","stimulus","from","a","virus","is","received","and","converted","into","a","molecular","signal","."),4261429). assertion_content_comment('tOboGo_DetectionOfVisibleLight',s("The","series","of","events","in","which","a","visible","light","stimulus","is","received","by","a","cell","and","converted","into","a","molecular","signal",".","A","visible","light","stimulus","is","electromagnetic","radiation","that","can","be","perceived","visually","by","an","organism",";","for","organisms","lacking","a","visual","system",",","this","can","be","defined","as","light","with","a","wavelength","within","the","range","380","to","780","nm","."),4020906). assertion_content_comment('tOboGo_DetectionOfWounding',s("The","series","of","events","by","which","an","injury","stimulus","is","received","and","converted","into","a","molecular","signal","."),4320997). assertion_content_comment('tOboGo_DetectionOfYeast',s("The","series","of","events","in","which","a","stimulus","from","a","yeast","is","received","and","converted","into","a","molecular","signal","."),4384423). assertion_content_comment('tOboGo_DeterminateInflorescenceMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","determinate","inflorescences","are","generated","and","organized",".","A","determinate","inflorescence","is","one","that","can","only","produce","a","predetermined","number","of","floral","meristems","."),4384835). assertion_content_comment('tOboGo_DeterminationOfAdultLifespan',s("The","control","of","viability","and","duration","in","the","adult","phase","of","the","life-cycle","."),4020751). assertion_content_comment('tOboGo_DeterminationOfAffect',s("Any","process","in","which","an","emotional","response","is","associated","with","a","particular","sensory","stimulation","."),4274101). assertion_content_comment('tOboGo_DeterminationOfBilateralSymmetry',s("The","establishment","of","an","organism","'","s","body","plan","or","part","of","an","organism","with","respect","to","a","single","longitudinal","plane",".","The","pattern","can","either","be","symmetric",",","such","that","the","halves","are","mirror","images",",","or","asymmetric","where","the","pattern","deviates","from","this","symmetry","."),3988492). assertion_content_comment('tOboGo_DeterminationOfDigestiveTractLeftRightAsymmetry',s("Determination","of","the","asymmetric","location","of","various","parts","of","the","digestive","tract","with","respect","to","the","left","and","right","halves","of","the","organism",".","The","digestive","tract","is","the","anatomical","structure","through","which","food","passes","and","is","processed","."),4125547). assertion_content_comment('tOboGo_DeterminationOfDorsalIdentity',s("Determination","of","the","identity","of","part","of","an","organism","or","organ","where","those","parts","are","of","the","type","that","occur","in","the","dorsal","region",".","Identity","is","considered","to","be","the","aggregate","of","characteristics","by","which","a","structure","is","recognized","."),4103926). assertion_content_comment('tOboGo_DeterminationOfDorsalVentralAsymmetry',s("Determination","of","asymmetry","from","the","dorsal","to","the","ventral","side",";","as",",","the","dorsoventral","axis","."),4103902). assertion_content_comment('tOboGo_DeterminationOfGenitalDiscPrimordium',s("Allocation","of","embryonic","cells","to","the","genital","imaginal","disc","founder","populations",".","Early","in","development","at","the","blastoderm","stage",",","the","anlage","of","the","genital","disc","of","both","sexes","consists","of","three","primordia",":","the","female","genital","primoridum","lcoated","anteriorly",",","the","anal","primoridum","located","posteriorly",",","and","the","male","gential","primordium","between","the","two","."),4070889). assertion_content_comment('tOboGo_DeterminationOfHeartLeftRightAsymmetry',s("Determination","of","the","asymmetric","location","of","the","heart","with","respect","to","the","left","and","right","halves","of","the","organism","."),3988498). 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assertion_content_comment('tOboGo_DiacylglycerolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","diacylglycerol",",","a","glycerol","molecule","substituted","on","the","1","and","2","hydroxyl","groups","with","long","chain","fatty","acyl","residues","."),4350084). assertion_content_comment('tOboGo_DiacylglycerolCholinephosphotransferaseActivity',s("Catalysis","of","the","reaction",":","CDP-choline","+","1",",","2-diacylglycerol","=","CMP","+","a","phosphatidylcholine","."),4211251). assertion_content_comment('tOboGo_DiacylglycerolKinaseActivity',s("Catalysis","of","the","reaction",":","NTP","+","1",",","2-diacylglycerol","=","NDP","+","1",",","2-diacylglycerol-3-phosphate","."),4211231). assertion_content_comment('tOboGo_DiacylglycerolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","diacylglycerol",",","a","glycerol","molecule","substituted","on","the","1","and","2","hydroxyl","groups","with","long","chain","fatty","acyl","residues",".","DAG","is","a","normal","intermediate","in","the","biosynthesis","of","phosphatidyl","phospholipids","and","is","released","from","them","by","phospholipase","C","activity",".","DAG","from","phosphatidyl","inositol","polyphosphates","is","important","in","signal","transduction","."),4230589). assertion_content_comment('tOboGo_DiacylglycerolPyrophosphatePhosphataseActivity',s("Catalysis","of","the","reaction",":","a","1",",","2-diacyl-sn-glycerol","3-diphosphate","+","H2O","=","a","1",",","2-diacylglycerol-3-phosphate","+","phosphate","."),4363572). assertion_content_comment('tOboGo_DiacylLipopeptideBinding',s("Interacting","selectively","and","non-covalently","with","a","lipopeptide","containing","a","nonprotein","moiety","consisting","of","two","acyl","groups","."),4313226). assertion_content_comment('tOboGo_DiadenosinePolyphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","diadenosine","polyphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","phosphate","groups","attached","."),4294818). assertion_content_comment('tOboGo_DiadenosinePolyphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","diadenosine","polyphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","phosphate","groups","attached","."),4294753). assertion_content_comment('tOboGo_DiadenosinePolyphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","diadenosine","polyphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","phosphate","groups","attached","."),4294750). assertion_content_comment('tOboGo_DiadenosineTetraphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","diadenosine","tetraphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","four","phosphate","groups","attached","."),4294825). assertion_content_comment('tOboGo_DiadenosineTetraphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","diadenosine","tetraphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","four","phosphate","groups","attached","."),4294840). assertion_content_comment('tOboGo_DiadenosineTetraphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","diadenosine","tetraphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","four","phosphate","groups","attached","."),4294783). assertion_content_comment('tOboGo_DiadenosineTriphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","diadenosine","triphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","three","phosphate","groups","attached","."),4294854). assertion_content_comment('tOboGo_DiadenosineTriphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","diadenosine","triphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","three","phosphate","groups","attached","."),4294770). assertion_content_comment('tOboGo_DiadenosineTriphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","diadenosine","triphosphate",",","a","derivative","of","the","nucleoside","adenosine","with","three","phosphate","groups","attached","."),4294767). assertion_content_comment('tOboGo_Diakinesis',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","final","stage","of","prophase","I","in","meiosis",";","the","transition","to","meiotic","metaphase","I","."),3973768). assertion_content_comment('tOboGo_DiamineOxidaseActivity',s("Catalysis","of","the","reaction",":","a","diamine","+","H2O","+","O2","=","a","monoamine","+","NH3","+","hydrogen","peroxide","."),4186679). assertion_content_comment('tOboGo_DiamineTransaminaseActivity',s("Catalysis","of","the","reaction",":","an","alpha",",","omega-diamine","+","2-oxoglutarate","=","an","omega-aminoaldehyde","+","L-glutamate","."),4237661). assertion_content_comment('tOboGo_DiaminobutyrateAcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","L-2",",","4-diaminobutyrate","+","acetyl-CoA","=","N","(","4",")","-acetyl-L-2",",","4-diaminobutyrate","+","CoA","+","H","(","+",")"),4343079). assertion_content_comment('tOboGo_DiaminobutyrateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","L-2",",","4-diaminobutyrate","+","H","(","+",")","=","1",",","3-diaminopropane","+","CO","(","2",")"),4344895). assertion_content_comment('tOboGo_DiaminohydroxyphosphoribosylaminopyrimidineDeaminaseActivity',s("Catalysis","of","the","reaction",":","2",",","5-diamino-6-hydroxy-4-","(","5-phosphoribosylamino",")","-pyrimidine","+","H","(","2",")","O","+","H","(","+",")","=","5-amino-6-","(","5-phosphoribosylamino",")","uracil","+","NH","(","4",")","(","+",")"),4250409). assertion_content_comment('tOboGo_DiaminopimelateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","diaminopimelate",",","both","as","an","intermediate","in","lysine","biosynthesis","and","as","a","component","(","as","meso-diaminopimelate",")","of","the","peptidoglycan","of","Gram-negative","bacterial","cell","walls","."),4042317). assertion_content_comment('tOboGo_DiaminopimelateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","meso-2",",","6-diaminopimelate","+","H","(","+",")","=","L-lysine","+","CO","(","2",")"),4250319). assertion_content_comment('tOboGo_DiaminopimelateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","meso-2",",","6-diaminopimelate","+","H","(","2",")","O","+","NADP","(","+",")","=","L-2-amino-6-oxopimelate","+","H","(","+",")","+","NADPH","+","NH","(","4",")","(","+",")"),4376544). assertion_content_comment('tOboGo_DiaminopimelateEpimeraseActivity',s("Catalysis","of","the","reaction",":","LL-2",",","6-diaminopimelate","=","meso-2",",","6-diaminopimelate","."),4250308). assertion_content_comment('tOboGo_DiaminopimelateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","diaminopimelate",",","the","anion","of","the","dicarboxylic","acid","2",",","6-diaminoheptanedioic","acid",".","It","is","an","intermediate","in","lysine","biosynthesis","and","as","a","component","(","as","meso-diaminopimelate",")","of","the","peptidoglycan","of","Gram-negative","bacterial","cell","walls","."),4042295). assertion_content_comment('tOboGo_DiaminopimelateTransport',s("The","directed","movement","of","diaminopimelate",",","the","anion","of","2",",","6-diaminoheptanedioic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4294003). assertion_content_comment('tOboGo_Diapedesis',s("The","passage","of","a","leukocyte","between","the","tight","junctions","of","endothelial","cells","lining","blood","vessels",",","typically","the","fourth","and","final","step","of","cellular","extravasation","."),4082807). assertion_content_comment('tOboGo_DiaphragmContraction',s("A","process","in","which","force","is","generated","within","involuntary","skeletal","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","This","process","occurs","in","the","diaphragm",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","diaphragm","is","a","striated","muscle","that","is","necessary","for","the","process","of","respiratory","gaseous","exchange","."),4373312). assertion_content_comment('tOboGo_DiaphragmDevelopment',s("The","progression","of","the","diaphragm","over","time","from","its","initial","formation","to","the","mature","structure",".","The","diaphragm","is","a","skeletal","muscle","that","is","responsible","for","contraction","and","expansion","of","the","lungs","."),4116262). assertion_content_comment('tOboGo_DiaphragmMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","diaphragm","are","generated","and","organized","."),4116272). assertion_content_comment('tOboGo_DiarylpropanePeroxidaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-bis-","(","3",",","4-dimethoxyphenyl",")","propane-1",",","3-diol","+","H","(","2",")","O","(","2",")","=","1-","(","3",",","4-dimethoxyphenyl",")","ethane-1",",","2-diol","+","H","(","2",")","O","+","veratraldehyde","."),4306024). assertion_content_comment('tOboGo_DiazepamBindingInhibitorActivity',s("OBSOLETE",".","The","diazepam","binding","inhibitor","is","a","10kDa","86-residue","polypeptide","that","acts","as","an","endogenous","ligand","for","a","mitochondrial","receptor","(","formerly","regarded","as","a","peripheral","benzodiazepine","binding","site",")","in","steroidogenic","cells","and","regulates","stimulation","of","steroidogenesis","by","tropic","hormones",".","It","also","binds","to","the","GABA-A","receptor","and","modulates","glucose-dependent","insulin","secretion","and","synthesis","of","acyl-CoA","esters","."),4247063). assertion_content_comment('tOboGo_DiazepamBinding',s("Interacting","selectively","and","non-covalently","with","diazepam",",","one","of","the","most","widely","used","benzodiazepine","drugs",".","It","is","used","as","an","anti-anxiety-hypnotic","agent","and","has","the","proprietary","name","Valium","."),4247042). assertion_content_comment('tOboGo_DibenzofuranCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dibenzofuran",",","a","substance","composed","of","two","benzene","rings","linked","by","one","ether","bond","and","one","carbon-carbon","bond","."),4240286). assertion_content_comment('tOboGo_DibenzofuranMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dibenzofuran",",","a","substance","composed","of","two","benzene","rings","linked","by","one","ether","bond","and","one","carbon-carbon","bond",".","Dibenzofuran","is","a","white","crystalline","solid","created","from","the","production","of","coal","tar","and","used","as","an","insecticide","and","an","intermediate","in","the","production","of","other","chemicals","."),4240281). assertion_content_comment('tOboGo_DibenzothiopheneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dibenzothiophene",",","a","substance","composed","of","two","benzene","rings","linked","by","one","sulfide","bond","and","one","carbon-carbon","bond","."),4273360). assertion_content_comment('tOboGo_DibenzothiopheneDesulfurization',s("The","removal","of","the","sulfur","atom","from","dibenzothiophene",",","a","substance","composed","of","two","benzene","rings","linked","by","one","sulfide","bond","and","one","carbon-carbon","bond","."),4273319). assertion_content_comment('tOboGo_DibenzothiopheneDihydrodiolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","cis-1",",","2-dihydroxy-1",",","2-dihydrodibenzothiophene","+","NAD","(","+",")","=","1",",","2-dihydroxydibenzothiophene","+","H","(","+",")","+","NADH","."),4278521). assertion_content_comment('tOboGo_DibenzothiopheneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","dibenzothiophene","+","NADH","+","O2","+","H","+","=","NAD","+","+","cis-1",",","2-dihydroxy-1",",","2-dihydrodibenzothiophene","."),4276868). assertion_content_comment('tOboGo_DibenzothiopheneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dibenzothiophene",",","a","substance","composed","of","two","benzene","rings","linked","by","one","sulfide","bond","and","one","carbon-carbon","bond",".","Dibenzothiophene","derivatives","can","be","detected","in","diesel","oil","following","hydrodesulfurization","treatment","to","remove","sulfur","compounds","that","would","otherwise","generate","sulfur","oxides","during","combustion","."),4273314). assertion_content_comment('tOboGo_DibenzothiopheneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","dibenzothiophene","+","NADH","+","H","+","+","O2","=","dibenzothiophene-5-oxide","+","NAD","+","+","H2O","."),4276340). assertion_content_comment('tOboGo_DibutylPhthalateBinding',s("Interacting","selectively","and","non-covalently","with","dibutyl","phthalate",",","C","(","16",")","H","(","22",")","O","(","4",")"),4382740). assertion_content_comment('tOboGo_Dicarboxylate_InorganicPhosphateAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","dicarboxylate","(","out",")","+","inorganic","phosphate","(","in",")","=","dicarboxylate","(","in",")","+","inorganic","phosphate","(","out",")"),4295963). assertion_content_comment('tOboGo_DicarboxylateSuccinateFumarateMalateAntiporterActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4295978). assertion_content_comment('tOboGo_DicarboxylicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dicarboxylic","acids",",","any","organic","acid","containing","two","carboxyl","(","-COOH",")","groups","."),4233421). assertion_content_comment('tOboGo_DicarboxylicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dicarboxylic","acids",",","any","organic","acid","containing","two","carboxyl","(","-COOH",")","groups","."),4238189). assertion_content_comment('tOboGo_DicarboxylicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dicarboxylic","acids",",","any","organic","acid","containing","two","carboxyl","(","COOH",")","groups","or","anions","(","COO-",")"),4042290). assertion_content_comment('tOboGo_DicarboxylicAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","dicarboxylic","acids","from","one","side","of","the","membrane","to","the","other",".","A","dicarboxylic","acid","is","an","organic","acid","with","two","COOH","groups","."),4215984). assertion_content_comment('tOboGo_DicarboxylicAcidTransport',s("The","directed","movement","of","dicarboxylic","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4164069). assertion_content_comment('tOboGo_DichloroacetateHalidohydrolaseActivity',s("Catalysis","of","the","reaction",":","dichloroacetate","+","H2O","=","2","HCl","+","glyoxylate","."),4274333). assertion_content_comment('tOboGo_DichloromethaneDehalogenaseActivity',s("Catalysis","of","the","reaction",":","dichloromethane","+","H","(","2",")","O","=","2","chloride","+","formaldehyde","+","2","H","(","+",")"),4273552). assertion_content_comment('tOboGo_DichloromethaneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dichloromethane",",","a","dichlorinated","derivative","of","methane",".","It","is","a","colorless","organic","liquid","with","a","sweet",",","chloroform-like","odor",",","often","used","as","a","paint","remover","."),4272322). assertion_content_comment('tOboGo_DichloromuconateCycloisomeraseActivity',s("Catalysis","of","the","reaction",":","2",",","4-dichloro-2",",","5-dihydro-5-oxofuran-2-acetate","=","2",",","4-dichloro-cis",",","cis-muconate","."),4273708). assertion_content_comment('tOboGo_DichotomousSubdivisionOfAnEpithelialTerminalUnit',s("The","process","in","which","an","epithelial","cord",",","rod","or","tube","bifurcates","at","its","end","."),4112416). assertion_content_comment('tOboGo_DichotomousSubdivisionOfProstateEpithelialCordTerminalUnit',s("The","process","in","which","a","prostate","epithelial","cord","bifurcates","at","its","end","."),4116314). assertion_content_comment('tOboGo_DichotomousSubdivisionOfTerminalUnitsInvolvedInLungBranching',s("The","process","in","which","a","lung","bud","bifurcates","."),4117712). assertion_content_comment('tOboGo_DichotomousSubdivisionOfTerminalUnitsInvolvedInMammaryGlandDuctMorphogenesis',s("The","process","in","which","the","terminal","end","of","a","mammary","duct","bifurcates","."),4116951). assertion_content_comment('tOboGo_DichotomousSubdivisionOfTerminalUnitsInvolvedInSalivaryGlandBranching',s("The","process","in","which","a","salivary","epithelial","cord","bifurcates","at","its","end","."),4112420). assertion_content_comment('tOboGo_DichotomousSubdivisionOfTerminalUnitsInvolvedInUretericBudBranching',s("The","process","in","which","a","ureteric","bud","bifurcates","at","its","end","."),4112515). assertion_content_comment('tOboGo_DidemethylisoproturonAmidohydrolaseActivity',s("Catalysis","of","the","reaction",":","didemethylisoproturon","+","H2O","=","carbamic","acid","+","4-isopropylaniline","."),4352651). assertion_content_comment('tOboGo_DidemethylisoproturonDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","didemethylisoproturon","+","H2O","=","4","'","-","(","2-hydroxyisopropyl",")","phenylurea","+","2","H","+","+","2","e-","."),4352642). assertion_content_comment('tOboGo_DIDPPhosphorylation',s("The","process","of","introducing","a","phosphate","group","into","dIDP",",","deoxyinosine","diphosphate",",","to","produce","dITP","."),4227465). assertion_content_comment('tOboGo_DiencephalonDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","diencephalon","over","time",",","from","its","formation","to","the","mature","structure",".","The","diencephalon","is","the","paired","caudal","parts","of","the","prosencephalon","from","which","the","thalamus",",","hypothalamus",",","epithalamus","and","subthalamus","are","derived",";","these","regions","regulate","autonomic",",","visceral","and","endocrine","function",",","and","process","information","directed","to","the","cerebral","cortex","."),4041020). assertion_content_comment('tOboGo_DiencephalonMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","diencephalon","are","generated","and","organized",".","The","diencephalon","is","the","paired","caudal","parts","of","the","prosencephalon","from","which","the","thalamus",",","hypothalamus",",","epithalamus","and","subthalamus","are","derived",";","these","regions","regulate","autonomic",",","visceral","and","endocrine","function",",","and","process","information","directed","to","the","cerebral","cortex","."),4105625). assertion_content_comment('tOboGo_Diestrus',s("The","estrous","cycle","phase","which","is","a","period","of","sexual","quiescence","and","represents","the","phase","of","the","mature","corpus","luteum","."),4160125). assertion_content_comment('tOboGo_DietInducedThermogenesis',s("The","process","that","results","in","increased","metabolic","rate","in","tissues","of","an","organism",".","It","is","triggered","by","the","detection","of","dietary","excess",".","This","process","is","achieved","via","signalling","in","the","sympathetic","nervous","system","."),3991059). assertion_content_comment('tOboGo_DigalactosyldiacylglycerolSynthaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-diacyl-3-beta-D-galactosyl-sn-glycerol","+","UDP-D-galactose","=","3-","[","alpha-D-galactosyl-","(","1-","&","gt",";","6",")","-beta-D-galactosyl","]","-1",",","2-diacyl-sn-glycerol","+","H","(","+",")","+","UDP","."),4350135). assertion_content_comment('tOboGo_Digestion',s("The","whole","of","the","physical",",","chemical",",","and","biochemical","processes","carried","out","by","multicellular","organisms","to","break","down","ingested","nutrients","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),3991763). assertion_content_comment('tOboGo_DigestiveHormoneActivity',s("The","action","characteristic","of","a","hormone","that","takes","part","in","the","digestion","process","."),4300310). assertion_content_comment('tOboGo_DigestiveSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","digestive","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","digestive","system","is","the","entire","structure","in","which","digestion","takes","place",".","Digestion","is","all","of","the","physical",",","chemical",",","and","biochemical","processes","carried","out","by","multicellular","organisms","to","break","down","ingested","nutrients","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),4017615). assertion_content_comment('tOboGo_DigestiveSystemProcess',s("A","physical",",","chemical",",","or","biochemical","process","carried","out","by","living","organisms","to","break","down","ingested","nutrients","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),4035291). assertion_content_comment('tOboGo_DigestiveTractDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","digestive","tract","over","time",",","from","its","formation","to","the","mature","structure",".","The","digestive","tract","is","the","anatomical","structure","through","which","food","passes","and","is","processed","."),4017617). assertion_content_comment('tOboGo_DigestiveTractMesodermDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","digestive","tract","mesoderm","over","time",",","from","its","formation","to","the","mature","structure",".","The","digestive","tract","mesoderm","is","portion","of","the","middle","layer","of","the","three","primary","germ","layers","of","the","embryo","which","will","go","on","to","form","part","of","the","digestive","tract","of","the","organism","."),4018375). assertion_content_comment('tOboGo_DigestiveTractMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","digestive","tract","are","generated","and","organized",".","The","digestive","tract","is","the","anatomical","structure","through","which","food","passes","and","is","processed","."),4017622). assertion_content_comment('tOboGo_DiglucosylDiacylglycerolSynthaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-diacyl-3-O-","(","alpha-D-glucopyranosyl",")","-sn-glycerol","+","UDP-D-glucose","=","UDP","+","1",",","2-diacyl-3-O-","(","alpha-D-glucopyranosyl","(","1",",","2",")","-O-alpha-D-glucopyranosyl",")","-sn-glycerol","."),4367228). assertion_content_comment('tOboGo_DiguanidinobutanaseActivity',s("Catalysis","of","the","reaction",":","1",",","4-diguanidinobutane","+","H","(","2",")","O","=","agmatine","+","urea","."),4376489). assertion_content_comment('tOboGo_DiguanylateCyclaseActivity',s("Catalysis","of","the","reaction",":","2","GTP","=","cyclic","di-3","'",",","5","'","-guanylate","+","2","diphosphate","+","2","H","(","+",")"),4191248). assertion_content_comment('tOboGo_DihemeClassICytochromeC',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4258994). assertion_content_comment('tOboGo_DihydrideTNPTautomeraseActivity',s("Catalysis","of","the","reaction",":","TNP","dihydride","Meisenheimer","complex","(","aci","form",")","=","TNP","dihydride","Meisenheimer","complex","(","nitro","form",")"),4349812). assertion_content_comment('tOboGo_DihydrobenzophenanthridineOxidaseActivity',s("Catalysis","of","the","reaction",":","O2","+","dihydrosanguinarine","=","H2O2","+","sanguinarine","."),4365654). assertion_content_comment('tOboGo_DihydrobiopterinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","dihydrobiopterin",",","a","reduced","pteridine","derivative","related","to","folic","acid",";","it","acts","as","an","electron","carrier","in","tyrosine","biosynthesis","and","its","quinoid","form","is","produced","by","oxidation","of","tetrahydrobiopterin","in","several","biological","hydroxylation","reactions","."),4228388). assertion_content_comment('tOboGo_DihydrobiopterinReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228396). assertion_content_comment('tOboGo_DihydrobunololDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","dihydrobunolol","+","NADP","(","+",")","=","bunolol","+","H","(","+",")","+","NADPH","."),4376478). assertion_content_comment('tOboGo_DihydrocamalexicAcidDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","dihydrocamalexic","acid","=","camalexin","+","CO2","+","H","+"),4335118). assertion_content_comment('tOboGo_DihydroceramidaseActivity',s("Catalysis","of","the","reaction",":","a","dihydroceramide","+","H2O","=","a","fatty","acid","+","dihydrosphingosine","."),4172815). assertion_content_comment('tOboGo_DihydrocoumarinHydrolaseActivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydrocoumarin","+","H","(","2",")","O","=","3-","(","2-hydroxyphenyl",")","propanoate","+","H","(","+",")"),4376467). assertion_content_comment('tOboGo_DihydrodipicolinateReductaseActivity',s("Catalysis","of","the","reaction",":","2",",","3",",","4",",","5-tetrahydrodipicolinate","+","NADP","+","=","2",",","3-dihydrodipicolinate","+","NADPH","+","H","+"),4250335). assertion_content_comment('tOboGo_DihydrodipicolinateSynthaseActivity',s("Catalysis","of","the","reaction",":","L-aspartate","4-semialdehyde","+","pyruvate","=","(","S",")","-2",",","3-dihydrodipicolinate","+","2","H","(","2",")","O","+","H","(","+",")"),4250010). assertion_content_comment('tOboGo_DihydroflavonolThioleLyaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4261986). assertion_content_comment('tOboGo_DihydrofolateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dihydrofolate",",","the","dihydroxylated","derivative","of","folate","."),4229950). assertion_content_comment('tOboGo_DihydrofolateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dihydrofolate",",","the","dihydroxylated","derivative","of","folate","."),4229908). assertion_content_comment('tOboGo_DihydrofolateReductaseActivity',s("Catalysis","of","the","reaction",":","5",",","6",",","7",",","8-tetrahydrofolate","+","NADP","+","=","7",",","8-dihydrofolate","+","NADPH","+","H","+"),4211139). assertion_content_comment('tOboGo_DihydrofolateReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4229913). assertion_content_comment('tOboGo_DihydrofolateSynthaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","dihydropterate","+","L-glutamate","=","ADP","+","phosphate","+","dihydrofolate","."),4249988). assertion_content_comment('tOboGo_DihydrofolicAcidBinding',s("Interacting","selectively","and","non-covalently","with","dihydrofolic","acid",",","a","folic","acid","in","which","the","bicyclic","pteridine","structure","is","in","the","dihydro",",","partially","reduced","form",";","they","are","intermediates","in","folate","metabolism","and","are","reduced","to","their","tetrahydro",",","reduced","forms","."),4282144). assertion_content_comment('tOboGo_DihydrolipoamideBranchedChainAcyltransferaseActivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","dihydrolipoamide","=","CoA","+","S-acyldihydrolipoamide",",","where","the","acyl","group","is","a","branched","chain","."),4211128). assertion_content_comment('tOboGo_DihydrolipoamideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dihydrolipoamide",",","the","reduced","form","of","lipoamide",",","produced","as","an","intermediate","in","the","reactions","in","which","lipoamide","acts","as","a","cofactor","."),4228299). assertion_content_comment('tOboGo_DihydrolipoamideReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228306). assertion_content_comment('tOboGo_DihydrolipoylDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","protein","N6-","(","dihydrolipoyl",")","lysine","+","NAD","+","=","protein","N6-","(","lipoyl",")","lysine","+","NADH","+","H","+"),4211096). assertion_content_comment('tOboGo_DihydrolipoylDehydrogenaseComplex',s("A","protein","complex","that","possesses","alpha-ketoglutarate","dehydrogenase","activity","."),4221126). assertion_content_comment('tOboGo_DihydrolipoylproteinReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228318). assertion_content_comment('tOboGo_DihydromonapterinReductaseActivity',s("Catalysis","of","the","reaction",":","7",",","8-dihydromonapterin","+","NADPH","=","tetrahydromonapterin","+","NADP","+"),4165080). assertion_content_comment('tOboGo_DihydroneopterinAldolaseActivity',s("Catalysis","of","the","reaction",":","2-amino-4-hydroxy-6-","(","D-erythro-1",",","2",",","3-trihydroxypropyl",")","-7",",","8-dihydropteridine","=","2-amino-4-hydroxy-6-hydroxymethyl-7",",","8-dihydropteridine","+","glycolaldehyde","."),4211344). assertion_content_comment('tOboGo_DihydroneopterinMonophosphatePhosphataseActivity',s("Catalysis","of","the","reaction",":","dihydroneopterin","monophosphate","=","dihydroneopterin","+","phosphate","."),4237785). assertion_content_comment('tOboGo_DihydroneopterinTriphosphatePyrophosphohydrolaseActivity',s("Catalysis","of","the","reaction",":","dihydroneopterin","triphosphate","=","dihydroneopterin","phosphate","+","diphosphate","."),4237795). assertion_content_comment('tOboGo_DihydronicotinamideRibosideQuinoneReductaseActivity',s("Catalysis","of","the","reaction",":","1-","(","beta-D-ribofuranosyl",")","-1",",","4-dihydronicotinamide","+","a","quinone","=","1-","(","beta-D-ribofuranosyl",")","nicotinamide","+","a","hydroquinone","."),4361530). assertion_content_comment('tOboGo_DihydroorotaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-dihydroorotate","+","H","(","2",")","O","=","N-carbamoyl-L-aspartate","+","H","(","+",")"),4211356). assertion_content_comment('tOboGo_DihydroorotateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-dihydroorotate","+","A","=","AH","(","2",")","+","orotate","."),4211284). assertion_content_comment('tOboGo_DihydroorotateOxidaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-dihydroorotate","+","O","(","2",")","=","H","(","2",")","O","(","2",")","+","orotate","."),4211292). assertion_content_comment('tOboGo_DihydrophloroglucinolHydrolaseActivity',s("Catalysis","of","the","reaction",":","dihydrophloroglucinol","+","OH-","=","3-hydroxy-5-oxohexanoate","."),4274639). assertion_content_comment('tOboGo_DihydropteridineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","6",",","7-dihydropteridine",",","a","bicyclic","compound","with","the","formula","C6H6N4","."),4228416). assertion_content_comment('tOboGo_DihydropteridineReduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228422). assertion_content_comment('tOboGo_DihydropterinDeaminaseActivity',s("Catalysis","of","the","reaction",":","7",",","8-dihydropterin","+","H2O","=","7",",","8-dihydrolumazine","+","NH3","."),4211378). assertion_content_comment('tOboGo_DihydropterinOxidaseActivity',s("Catalysis","of","the","reaction",":","a","7",",","8-dihydropteridine","+","O2","=","a","pterin","+","hydrogen","peroxide","."),4211369). assertion_content_comment('tOboGo_DihydropteroateSynthaseActivity',s("Catalysis","of","the","reaction",":","2-amino-4-hydroxy-6-hydroxymethyl-7",",","8-dihydropteridine","diphosphate","+","4-aminobenzoate","=","diphosphate","+","dihydropteroate","."),4211388). assertion_content_comment('tOboGo_DihydropyrimidinaseActivity',s("Catalysis","of","the","reaction",":","5",",","6-dihydrouracil","+","H2O","=","3-ureidopropionate","."),4211314). assertion_content_comment('tOboGo_DihydropyrimidineDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","5",",","6-dihydrouracil","+","NADP","+","=","uracil","+","NADPH","+","H","+"),4267450). assertion_content_comment('tOboGo_DihydrouracilDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","5",",","6-dihydrouracil","+","NAD","+","=","uracil","+","NADH","+","H","+"),4211329). assertion_content_comment('tOboGo_DihydrouracilOxidaseActivity',s("Catalysis","of","the","reaction",":","5",",","6-dihydrouracil","+","O","(","2",")","=","H","(","2",")","O","(","2",")","+","uracil","."),4376586). assertion_content_comment('tOboGo_DihydroxydibenzothiopheneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxydibenzothiophene","+","O2","=","cis-4-","(","2-","(","3-hydroxy",")","-thionaphthenyl",")","-2-oxo-3-butenoate","."),4278827). assertion_content_comment('tOboGo_DihydroxyfluoreneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","a","dihydroxyfluorene","+","O2","=","the","corresponding","2-hydroxy-4-","(","oxo-1",",","3-dihydro-2H-inden-ylidene",")","but-2-enoic","acid","."),4237177). assertion_content_comment('tOboGo_DihydroxyfumarateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","dihydroxyfumarate","+","H","(","+",")","=","2-hydroxy-3-oxopropanoate","+","CO","(","2",")"),4376596). assertion_content_comment('tOboGo_DihydroxyphenylalanineTransaminaseActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","L-dopa","=","3",",","4-dihydroxyphenylpyruvate","+","L-glutamate","."),4368947). assertion_content_comment('tOboGo_DiiodophenylpyruvateReductaseActivity',s("Catalysis","of","the","reaction",":","3-","(","3",",","5-diiodo-4-hydroxyphenyl",")","lactate","+","NAD","(","+",")","=","3-","(","3",",","5-diiodo-4-hydroxyphenyl",")","pyruvate","+","H","(","+",")","+","NADH","."),4376699). assertion_content_comment('tOboGo_DiiodotyrosineTransaminaseActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","3",",","5-diiodo-L-tyrosine","=","3-","(","3",",","5-diiodo-4-hydroxyphenyl",")","pyruvate","+","L-glutamate","."),4376686). assertion_content_comment('tOboGo_DIMDIPCellWallLayerAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components",",","including","(","phenyl",")","phthiocerol",",","phthiodiolone",",","phthiotriol","dimycocerosate","and","diphthioceranate",",","to","form","the","DIM/DIP","layer","of","the","Actinobacterium-type","cell","wall","."),4129401). assertion_content_comment('tOboGo_DimericIgAImmunoglobulinComplex',s("A","protein","complex","composed","of","two","monomeric","IgA","immunoglobulin","complexes","linked","through","both","direct","disulfide","bonds","and","through","a","disulfide","binded","monomer","of","J","chain","acting","as","a","bridge",".","Each","IgA","monomer","consists","of","two","identical","immunoglobulin","heavy","chains","of","an","IgA","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","Dimeric","IgA","is","sometimes","complexed","additionally","with","secretory","component",",","and","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169598). assertion_content_comment('tOboGo_DimericPositiveTranscriptionElongationFactorComplexB',s("A","positive","transcription","elongation","factor","complex","b","that","comprises","two","subunits",";","an","example","is","the","budding","yeast","complex","containing","Svg1p","(","also","called","Bur1p",")","and","Bur2p","."),4177263). assertion_content_comment('tOboGo_DimericRibonucleasePComplex',s("A","ribonuclease","P","complex","that","contains","a","single","RNA","molecule","that","is","necessary","and","usually","sufficient","for","catalysis",",","and","a","single","protein","molecule",".","Examples","of","this","complex","are","found","in","Bacterial","species","."),4308292). assertion_content_comment('tOboGo_DimethylallylcistransferaseActivity',s("Catalysis","of","the","reaction",":","dimethylallyl","diphosphate","+","isopentenyl","diphosphate","=","diphosphate","+","neryl","diphosphate","."),4376712). assertion_content_comment('tOboGo_DimethylallylDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dimethylallyl","diphosphate","."),4273095). assertion_content_comment('tOboGo_DimethylallylDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dimethylallyl","diphosphate","."),4273088). assertion_content_comment('tOboGo_DimethylallyltranstransferaseActivity',s("Catalysis","of","the","reaction",":","dimethylallyl","diphosphate","+","isopentenyl","diphosphate","=","diphosphate","+","geranyl","diphosphate","."),4210754). assertion_content_comment('tOboGo_DimethylamineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","electron-transferring","flavoprotein","+","H2O","+","dimethylamine","=","reduced","electron-transferring","flavoprotein","+","formaldehyde","+","methylamine","."),4365665). assertion_content_comment('tOboGo_DimethylamineMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","dimethylamine","+","a","dimethylamine","corrinoid","protein","=","a","methylated","dimethylamine","corrinoid","protein","+","methylamine","."),4327707). assertion_content_comment('tOboGo_DimethylargininaseActivity',s("Catalysis","of","the","reaction",":","N","(","G",")",",","N","(","G",")","-dimethyl-L-arginine","+","H2O","=","dimethylamine","+","L-citrulline","."),4304798). assertion_content_comment('tOboGo_DimethylarsinateReductaseActivity',s("Catalysis","of","the","reaction",":","dimethylarsinate","+","3","H","+","+","2","e-","=","dimethylarsinous","acid","+","H2O","."),4352900). assertion_content_comment('tOboGo_DimethylarsiniteMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","dimethylarsenous","acid","+","R2S-CH3","=","trimethylarsine","oxide","+","R2SH","."),4352795). assertion_content_comment('tOboGo_DimethylEtherMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dimethyl","ether",",","CH3-O-CH3",",","the","simplest","ether",".","Dimethyl","ether",",","also","known","wood","ether","and","methyl","ether",",","is","a","colorless","gas","that","has","been","used","in","refrigeration","applications","."),4272443). assertion_content_comment('tOboGo_DimethylglycineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","N",",","N-dimethylglycine","+","A","+","H","(","2",")","O","=","AH","(","2",")","+","formaldehyde","+","sarcosine","."),4376639). assertion_content_comment('tOboGo_DimethylglycineOxidaseActivity',s("Catalysis","of","the","reaction",":","N",",","N-dimethylglycine","+","H","(","2",")","O","+","O","(","2",")","=","formaldehyde","+","H","(","2",")","O","(","2",")","+","sarcosine","."),4376676). assertion_content_comment('tOboGo_DimethylmalateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-3",",","3-dimethylmalate","+","NAD","(","+",")","=","3-methyl-2-oxobutanoate","+","CO","(","2",")","+","NADH","."),4376665). assertion_content_comment('tOboGo_DimethylmaleateHydrataseActivity',s("Catalysis","of","the","reaction",":","(","2R",",","3S",")","-2",",","3-dimethylmalate","=","dimethylmaleate","+","H","(","2",")","O","."),4376070). assertion_content_comment('tOboGo_DimethylmalonateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","dimethylmalonate","+","H","+","=","isobutyrate","+","CO2","."),4349622). assertion_content_comment('tOboGo_DimethylnitrosamineDemethylaseActivity',s("Catalysis","of","the","removal","of","a","methyl","group","from","N-nitrosodimethylamine","."),4210742). assertion_content_comment('tOboGo_DimethylpropiothetinDethiomethylaseActivity',s("Catalysis","of","the","reaction",":","S",",","S-dimethyl-beta-propiothetin","=","acrylate","+","dimethyl","sulfide","+","H","(","+",")"),4376081). assertion_content_comment('tOboGo_DimethylsilanediolCatabolicProcess',s("The","aerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dimethylsilanediol",",","the","smallest","member","of","the","dialkylsilanediols",".","Dimethylsilanediol","is","the","monomer","of","polydimethylsiloxane",",","a","compound","which","can","be","found","in","a","wide","range","of","industrial","and","consumer","products","."),4314347). assertion_content_comment('tOboGo_DimethylsilanediolHydroxylaseActivity',s("Catalysis","of","the","reaction",":","dimethylsilanediol","+","O2","+","2","H","+","+","2","e-","=","H2O","+","hydroxymethylmethylsilanediol","."),4275627). assertion_content_comment('tOboGo_DimethylsilanediolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dimethylsilanediol",",","the","smallest","member","of","the","dialkylsilanediols",".","Dimethylsilanediol","is","the","monomer","of","polydimethylsiloxane",",","a","compound","which","can","be","found","in","a","wide","range","of","industrial","and","consumer","products","."),4314327). assertion_content_comment('tOboGo_DimethylSulfideMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","dimethyl","sulfide","+","NADH","+","O2","=","NAD","+","+","OH-","+","methanethiol","+","formaldehyde","."),4275931). assertion_content_comment('tOboGo_DimethylSulfoxideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dimethyl","sulfoxide",",","DMSO","(","C2H6OS",")",",","an","alkyl","sulfoxide","that","is","practically","odorless","in","its","purified","form",".","As","a","highly","polar","organic","liquid",",","it","is","a","powerful","solvent",".","Its","biological","activities","include","the","ability","to","penetrate","plant","and","animal","tissues","and","to","preserve","living","cells","during","freezing","."),4272415). assertion_content_comment('tOboGo_DimethylSulfoxideReductaseActivity',s("Catalysis","of","the","reaction",":","dimethyl","sulfoxide","+","H","+","=","dimethyl","sulfide","+","H2O","."),4259935). assertion_content_comment('tOboGo_DimethylSulfoxideReductaseComplex',s("An","enzyme","complex","that","catalyzes","the","formation","of","dimethyl","sulfide","from","dimethyl","sulfoxide","."),4260297). assertion_content_comment('tOboGo_DinucleotideInsertionOrDeletionBinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","a","dinucleotide","insertion","or","deletion","."),4329058). assertion_content_comment('tOboGo_DinucleotideRepeatInsertionBinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","a","dinucleotide","repeat","insertion","or","a","deletion","resulting","in","unpaired","dinucleotide","repeats","."),4329355). assertion_content_comment('tOboGo_DiolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","diol",",","any","alcohol","containing","two","hydroxyl","groups","attached","to","saturated","carbon","atoms","."),4074386). assertion_content_comment('tOboGo_DiolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","diol",",","any","alcohol","containing","two","hydroxyl","groups","attached","to","saturated","carbon","atoms","."),3992082). assertion_content_comment('tOboGo_DioleinTransacylationActivity',s("Catalysis","of","the","reaction",":","diolein","+","mono-olein","=","triolein","+","glycerol",".","Mono-olein",",","also","known","as","mono-oleoylglycerol",",","is","the","monoglyceride","formed","from","oleic","acid",",","9-octodecenoic","acid",";","diolein","is","also","known","as","dioleoylglycerol",",","and","triolein","as","trioleoylglycerol","and","olein","."),4287553). assertion_content_comment('tOboGo_DiolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","diol",",","any","alcohol","containing","two","hydroxyl","groups","attached","to","saturated","carbon","atoms","."),3992015). 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assertion_content_comment('tOboGo_DiphosphomevalonateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-5-diphosphomevalonate","+","ATP","=","ADP","+","CO","(","2",")","+","H","(","+",")","+","isopentenyl","diphosphate","+","phosphate","."),4210724). assertion_content_comment('tOboGo_DiphosphoricMonoesterHydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","a","diphosphoester","to","give","a","diphosphate","group","and","a","free","hydroxyl","group","."),4249397). assertion_content_comment('tOboGo_DiphosphotransferaseActivity',s("Catalysis","of","the","transfer","of","a","diphosphate","group","from","one","compound","(","donor",")","to","a","another","(","acceptor",")"),4189051). assertion_content_comment('tOboGo_DiphthineSynthaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","2-","(","3-carboxy-3-aminopropyl",")","-L-histidine","=","S-adenosyl-L-homocysteine","+","2-","(","3-carboxy-3-","(","methylammonio",")","propyl",")","-L-histidine","."),4210711). assertion_content_comment('tOboGo_Diplotene',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","fourth","stage","of","prophase","I","in","meiosis",",","in","which","the","homologous","chromosomes","begin","to","separate","and","the","synaptonemal","complex","dissolves","."),3973838). assertion_content_comment('tOboGo_DipyrrinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dipyrrins","(","pyrromethanes",")",",","compounds","containing","two","pyrrole","rings","linked","through","a","methine",",","-CH","=",",","group","."),4284615). assertion_content_comment('tOboGo_DipyrrinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dipyrrins","(","pyrromethanes",")",",","compounds","containing","two","pyrrole","rings","linked","through","a","methine",",","-CH","=",",","group","."),4284612). assertion_content_comment('tOboGo_DirectionalGuidanceOfInterneuronsInvolvedInMigrationFromTheSubpalliumToTheCortex',s("The","creation","and","reception","of","signals","that","control","the","direction","of","migration","of","interneurons","as","a","component","of","the","process","of","migration","from","the","subpallium","to","the","cortex","."),4050903). assertion_content_comment('tOboGo_DirectionalLocomotion',s("Self-propelled","movement","of","a","cell","or","organism","from","one","location","to","another","along","an","axis","."),4094287). 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assertion_content_comment('tOboGo_DisassemblyByHostOfSymbiontCellWall',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","the","symbiont","cell","wall",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4109795). assertion_content_comment('tOboGo_DisassemblyByOrganismOfCellularComponentInOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","cellular","components","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109784). assertion_content_comment('tOboGo_DisassemblyByOrganismOfCellWallOfOtherOrganismInvolvedInSymbioticInteraction',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","the","cell","wall","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4109764). assertion_content_comment('tOboGo_DisassemblyBySymbiontOfHostCellPMLBody',s("The","breakdown",",","by","the","symbiont",",","of","a","PML","body","within","a","host","cell",".","A","PML","body","is","a","nuclear","body","that","reacts","against","SP100","auto-antibodies","(","PML","=","promyelocytic","leukemia",")","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154610). assertion_content_comment('tOboGo_DisassemblyBySymbiontOfHostCellularComponent',s("The","chemical","reactions","and","pathways","performed","by","an","organism","resulting","in","the","breakdown","of","cellular","components","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4120955). assertion_content_comment('tOboGo_DisassemblyBySymbiontOfHostCellWall',s("The","breakdown","of","the","host","cell","wall",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4120975). assertion_content_comment('tOboGo_DisassemblyBySymbiontOfHostCuticle',s("The","process","in","which","a","symbiont","organism","effects","a","breakdown","of","the","host","organism","cuticle",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4083974). assertion_content_comment('tOboGo_DiscadenineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","discadenine",",","(","2S",")","-2-amino-4-","{","6-","[","(","3-methylbut-2-en-1-yl",")","amino","]","-3H-purin-3-yl","}","butanoic","acid","."),4360210). assertion_content_comment('tOboGo_DiscadenineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","discadenine",",","(","2S",")","-2-amino-4-","{","6-","[","(","3-methylbut-2-en-1-yl",")","amino","]","-3H-purin-3-yl","}","butanoic","acid","."),4360224). assertion_content_comment('tOboGo_DiscadenineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","discadenine",",","(","2S",")","-2-amino-4-","{","6-","[","(","3-methylbut-2-en-1-yl",")","amino","]","-3H-purin-3-yl","}","butanoic","acid","."),4360199). 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assertion_content_comment('tOboGo_DisseminatedNephrocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","structural","and/or","functional","features","of","a","disseminated","nephrocyte",".","A","disseminated","nephrocyte","is","an","insect","renal","cell","that","filters","hemolymph","and","is","found","at","scattered","locations","in","the","fat","body","or","other","tissues",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","and","its","subsequent","development","to","the","mature","state","."),4261629). 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assertion_content_comment('tOboGo_DisseminationOrTransmissionOfSymbiontFromHostByVector',s("The","movement","of","an","organism","from","one","host","to","another","(","or","another","place","in","the","environment",")","by","means","of","a","third","organism","(","often","an","insect","or","other","animal",")","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4289193). assertion_content_comment('tOboGo_DisseminationOrTransmissionOfSymbiontFromHost',s("The","movement","of","an","organism","from","a","host","to","another","host","or","from","a","host","to","another","place","in","the","environment",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4236685). assertion_content_comment('tOboGo_DissimilatorySulfateReduction',s("The","reduction","of","sulfate","to","hydrogen","sulfide",",","which","acts","as","a","terminal","electron","acceptor",".","Sulfate","is","activated","to","adenosine-phosphosulfate","(","APS",")","which","is","then","reduced","to","sulfite",",","which","is","in","turn","reduced","to","hydrogen","sulfide","."),4240773). assertion_content_comment('tOboGo_DistalConvolutedTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","distal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","distal","convoluted","tubule","is","a","portion","of","the","nephron","tubule","that","connects","the","loop","of","Henle","to","the","collecting","duct","."),4122967). assertion_content_comment('tOboGo_DistalStomachSmoothMuscleContraction',s("A","process","in","which","force","is","generated","within","smooth","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","This","process","occurs","in","the","distal","stomach",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","distal","stomach","is","composed","of","the","lower","body","and","antrum","and","develops","strong","peristaltic","phasic","contractions","that","increase","in","amplitude","as","they","propagate","toward","the","pylorus","."),4321181). 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assertion_content_comment('tOboGo_DiureticHormoneActivity',s("The","action","characteristic","of","a","diuretic","hormone",",","any","peptide","hormone","that",",","upon","receptor","binding",",","regulates","water","balance","and","fluid","secretion","."),4252993). assertion_content_comment('tOboGo_DiureticHormoneReceptorActivity',s("Combining","with","a","diuretic","hormone","to","initiate","a","change","in","cell","activity","."),4246960). assertion_content_comment('tOboGo_DivalentInorganicAnionHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","divalent","inorganic","anions","within","an","organism","or","cell","."),4156798). assertion_content_comment('tOboGo_DivalentInorganicCationHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","divalent","cations","within","an","organism","or","cell","."),4021027). assertion_content_comment('tOboGo_DivalentInorganicCationTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","inorganic","cations","with","a","valency","of","two","from","one","side","of","the","membrane","to","the","other",".","Inorganic","cations","are","atoms","or","small","molecules","with","a","positive","charge","that","do","not","contain","carbon","in","covalent","linkage","."),4156875). assertion_content_comment('tOboGo_DivalentInorganicCationTransport',s("The","directed","movement","of","inorganic","cations","with","a","valency","of","two","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Inorganic","cations","are","atoms","or","small","molecules","with","a","positive","charge","which","do","not","contain","carbon","in","covalent","linkage","."),4029718). assertion_content_comment('tOboGo_DivalentMetalIonExport',s("The","directed","movement","of","divalent","metal","cations",",","any","metal","ion","with","a","+","2","electric","charge",",","out","of","a","cell","or","organelle","."),4178803). assertion_content_comment('tOboGo_DivalentMetalIonTransport',s("The","directed","movement","of","divalent","metal","cations",",","any","metal","ion","with","a","+","2","electric","charge",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4029720). assertion_content_comment('tOboGo_DNAAlkylation',s("The","addition","of","alkyl","groups","to","many","positions","on","all","four","bases","of","DNA",".","Alkylating","agents","can","also","modify","the","bases","of","incoming","nucleotides","in","the","course","of","DNA","synthesis","."),4031954). 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assertion_content_comment('tOboGo_DNADamageResponseSignalTransductionByP53ClassMediatorResultingInCellCycleArrest',s("A","cascade","of","processes","induced","by","the","cell","cycle","regulator","phosphoprotein","p53",",","or","an","equivalent","protein",",","in","response","to","the","detection","of","DNA","damage","and","resulting","in","the","stopping","or","reduction","in","rate","of","the","cell","cycle","."),4232486). assertion_content_comment('tOboGo_DNADamageResponseSignalTransductionByP53ClassMediatorResultingInInductionOfApoptosis',s("A","cascade","of","processes","induced","by","the","cell","cycle","regulator","phosphoprotein","p53",",","or","an","equivalent","protein",",","in","response","to","the","detection","of","DNA","damage","and","resulting","in","the","initiation","of","apoptosis","(","programmed","cell","death",")"),4317174). assertion_content_comment('tOboGo_DNADamageResponseSignalTransductionByP53ClassMediatorResultingInTranscriptionOfP21ClassMediator',s("A","cascade","of","processes","induced","by","the","cell","cycle","regulator","phosphoprotein","p53",",","or","an","equivalent","protein",",","resulting","in","the","induction","of","the","transcription","of","p21","(","also","known","as","WAF1",",","CIP1","and","SDI1",")","or","any","equivalent","protein",",","in","response","to","the","detection","of","DNA","damage","."),4232475). assertion_content_comment('tOboGo_DNADamageResponseSignalTransductionByP53ClassMediator',s("A","cascade","of","processes","induced","by","the","cell","cycle","regulator","phosphoprotein","p53",",","or","an","equivalent","protein",",","in","response","to","the","detection","of","DNA","damage","."),4094537). assertion_content_comment('tOboGo_DNADamageResponseSignalTransductionResultingInInductionOfApoptosis',s("A","cascade","of","processes","initiated","by","the","detection","of","DNA","damage","and","resulting","in","the","induction","of","apoptosis","(","programmed","cell","death",")"),4253327). assertion_content_comment('tOboGo_DNADamageResponseSignalTransductionResultingInTranscription',s("A","cascade","of","processes","initiated","in","response","to","the","detection","of","DNA","damage",",","and","resulting","in","the","induction","of","transcription","."),4232473). assertion_content_comment('tOboGo_DNADealkylationInvolvedInDNARepair',s("The","repair","of","alkylation","damage",",","e.g",".","the","removal","of","the","alkyl","group","at","the","O6-position","of","guanine","by","O6-alkylguanine-DNA","alkyltransferase","(","AGT",")"),4011195). assertion_content_comment('tOboGo_DNADealkylation',s("The","removal","of","an","alkyl","group","from","one","or","more","nucleotides","within","an","DNA","molecule","."),4011192). assertion_content_comment('tOboGo_DNADeamination',s("The","removal","of","an","amino","group","from","a","nucleotide","base","in","DNA",".","An","example","is","the","deamination","of","cytosine","to","produce","uracil","."),4173606). assertion_content_comment('tOboGo_DNADemethylaseActivity',s("Catalysis","of","the","removal","of","a","methyl","group","from","one","or","more","nucleosides","within","a","DNA","molecule","."),4279819). assertion_content_comment('tOboGo_DNADemethylation',s("The","removal","of","a","methyl","group","from","one","or","more","nucleotides","within","an","DNA","molecule","."),4181690). assertion_content_comment('tOboGo_DNADuplexUnwinding',s("The","process","in","which","interchain","hydrogen","bonds","between","two","strands","of","DNA","are","broken","or","'","melted","'",",","generating","a","region","of","unpaired","single","strands","."),3976969). assertion_content_comment('tOboGo_DNAEndBinding',s("Interacting","selectively","and","non-covalently","with","the","ends","of","DNA","that","are","exposed","by","the","creation","of","double-strand","breaks","(","DSBs",")"),4300686). assertion_content_comment('tOboGo_DNAEndoreduplication',s("Regulated","re-replication","of","DNA","within","a","single","cell","cycle",",","resulting","in","an","increased","cell","ploidy",".","An","example","of","this","process","occurs","in","the","synthesis","of","Drosophila","salivary","gland","cell","polytene","chromosomes","."),4064795). assertion_content_comment('tOboGo_DNAFragmentationInvolvedInApoptoticNuclearChange',s("The","cleavage","of","DNA","during","apoptosis",",","which","usually","occurs","in","two","stages",":","cleavage","into","fragments","of","about","50","kbp","followed","by","cleavage","between","nucleosomes","to","yield","200","bp","fragments","."),4011239). assertion_content_comment('tOboGo_DNAGeometricChange',s("The","process","in","which","a","transformation","is","induced","in","the","geometry","of","a","DNA","double","helix",",","resulting","in","a","change","in","twist",",","writhe",",","or","both",",","but","with","no","change","in","linking","number",".","Includes","the","unwinding","of","double-stranded","DNA","by","helicases","."),3976967). assertion_content_comment('tOboGo_DNAHairpinBinding',s("Interacting","selectively","and","non-covalently","with","DNA","containing","a","hairpin",".","A","hairpin","structure","forms","when","a","DNA","strand","folds","back","on","itself","and","intrachain","base","pairing","occurs","between","inverted","repeat","sequences","."),4334738). assertion_content_comment('tOboGo_DNAHelicaseAComplex',s("A","homohexameric","protein","complex","that","possesses","DNA","helicase","activity",";","associates","with","DNA","polymerase","alpha-primase","and","translocates","in","the","5","'","to","3","'","direction","."),4338256). assertion_content_comment('tOboGo_DNAHelicaseActivity',s("Catalysis","of","the","reaction",":","NTP","+","H2O","=","NDP","+","phosphate",",","to","drive","the","unwinding","of","a","DNA","helix","."),4193406). assertion_content_comment('tOboGo_DNAHelicaseComplex',s("A","protein","complex","that","possesses","DNA","helicase","activity","."),4023700). assertion_content_comment('tOboGo_DNAHypermethylation',s("An","increase","in","the","epigenetic","methylation","of","cytosine","and","adenosine","residues","in","DNA","."),4288899). assertion_content_comment('tOboGo_DNAHypomethylation',s("An","decrease","in","the","epigenetic","methylation","of","cytosine","and","adenosine","residues","in","DNA","."),4288876). assertion_content_comment('tOboGo_DNAImportIntoCellInvolvedInTransformation',s("The","directed","movement","of","DNA","into","a","cell","that","contributes","to","the","process","of","transformation",",","the","uptake","of","foreign","genetic","material","into","a","cell","."),4023860). assertion_content_comment('tOboGo_DNAInsertionOrDeletionBinding',s("Interacting","selectively","and","non-covalently","with","double-stranded","DNA","containing","insertions","or","deletions","."),4329054). assertion_content_comment('tOboGo_DNAIntegration',s("The","process","in","which","a","segment","of","DNA","is","incorporated","into","another",",","usually","larger",",","DNA","molecule","such","as","a","chromosome","."),4045153). assertion_content_comment('tOboGo_DNAIntegrityCheckpoint',s("Any","cell","cycle","checkpoint","that","regulates","cell","cycle","progression","in","response","to","changes","in","DNA","structure","."),4126990). assertion_content_comment('tOboGo_DNALigaseActivity',s("Catalysis","of","the","formation","of","a","phosphodiester","bond","between","the","3","'","-hydroxyl","group","at","the","end","of","one","DNA","chain","and","the","5","'","-phosphate","group","at","the","end","of","another",".","This","reaction","requires","an","energy","source","such","as","ATP","or","NAD","+"),4183900). assertion_content_comment('tOboGo_DNALigaseATPActivity',s("Catalysis","of","the","reaction",":","ATP","+","deoxyribonucleotide","(","n",")","+","deoxyribonucleotide","(","m",")","=","AMP","+","diphosphate","+","deoxyribonucleotide","(","n","+","m",")"),4184097). assertion_content_comment('tOboGo_DNALigaseIVComplex',s("A","eukaryotically","conserved","protein","complex","that","contains","DNA","ligase","IV","and","is","involved","in","DNA","repair","by","non-homologous","end","joining",";","in","addition","to","the","ligase",",","the","complex","also","contains","XRCC4","or","a","homolog",",","e.g",".","Saccharomyces","Lif1p","."),4337203). assertion_content_comment('tOboGo_DNALigaseNADActivity',s("Catalysis","of","the","reaction",":","NAD","+","+","deoxyribonucleotide","(","n",")","+","deoxyribonucleotide","(","m",")","=","AMP","+","nicotinamide","nucleotide","+","deoxyribonucleotide","(","n","+","m",")"),4184124). assertion_content_comment('tOboGo_DNALigationInvolvedInDNARecombination',s("The","re-formation","of","a","broken","phosphodiester","bond","in","the","DNA","backbone",",","carried","out","by","DNA","ligase",",","that","contributes","to","DNA","recombination","."),4119449). assertion_content_comment('tOboGo_DNALigationInvolvedInDNARepair',s("The","re-formation","of","a","broken","phosphodiester","bond","in","the","DNA","backbone",",","carried","out","by","DNA","ligase",",","that","contributes","to","DNA","repair","."),4011056). assertion_content_comment('tOboGo_DNALigation',s("The","re-formation","of","a","broken","phosphodiester","bond","in","the","DNA","backbone",",","carried","out","by","DNA","ligase","."),4011053). assertion_content_comment('tOboGo_DNAMediatedTransformation',s("The","introduction","and","uptake","of","foreign","genetic","material","(","DNA","or","RNA",")","into","a","cell",",","and","often","the","expression","of","that","genetic","material","."),4023838). assertion_content_comment('tOboGo_DNAMetabolicProcess',s("Any","cellular","metabolic","process","involving","deoxyribonucleic","acid",".","This","is","one","of","the","two","main","types","of","nucleic","acid",",","consisting","of","a","long",",","unbranched","macromolecule","formed","from","one",",","or","more","commonly",",","two",",","strands","of","linked","deoxyribonucleotides","."),3969033). assertion_content_comment('tOboGo_DNAMethylationInvolvedInEmbryoDevelopment',s("The","covalent","transfer","of","a","methyl","group","to","C-5","of","cytosine","that","contributes","to","the","epigenetic","regulation","of","embryonic","gene","expression","."),4094138). assertion_content_comment('tOboGo_DNAMethylationInvolvedInGameteGeneration',s("The","covalent","transfer","of","a","methyl","group","to","C-5","of","cytosine","that","contributes","to","the","establishment","of","DNA","methylation","patterns","in","the","gamete","."),4094150). assertion_content_comment('tOboGo_DNAMethylationOnAdenine',s("The","covalent","transfer","of","a","methyl","group","to","N-6","of","adenine","in","a","DNA","molecule","."),4337501). assertion_content_comment('tOboGo_DNAMethylationOnCytosine',s("The","covalent","transfer","of","a","methyl","group","to","C-5","or","N-4","of","cytosine","in","a","DNA","molecule","."),4148978). assertion_content_comment('tOboGo_DNAMethylationOnCytosineWithinACGSequence',s("The","covalent","transfer","of","a","methyl","group","to","C-5","or","N-4","of","a","cytosine","located","within","a","CG","sequence","in","a","DNA","molecule","."),4333471). assertion_content_comment('tOboGo_DNAMethylationOnCytosineWithinACHHSequence',s("The","covalent","transfer","of","a","methyl","group",",","to","C-5","or","N-4",",","of","a","cytosine","located","within","an","asymmetric","CHH","sequence","in","a","DNA","molecule",".","H","stands","for","an","adenine",",","cytosine",",","or","thymine","nucleotide","."),4333449). assertion_content_comment('tOboGo_DNAMethylationOnCytosineWithinACNGSequence',s("The","covalent","transfer","of","a","methyl","group",",","to","C-5","or","N-4",",","of","a","cytosine","located","within","a","CNG","sequence","in","a","DNA","molecule",".","N","stands","for","any","nucleotide","."),4333461). assertion_content_comment('tOboGo_DNAMethylation',s("The","covalent","transfer","of","a","methyl","group","to","either","N-6","of","adenine","or","C-5","or","N-4","of","cytosine","."),4031958). assertion_content_comment('tOboGo_DNAModification',s("The","covalent","alteration","of","one","or","more","nucleotide","sites","in","DNA",",","resulting","in","a","change","in","its","properties","."),4011190). assertion_content_comment('tOboGo_DNANucleotidylexotransferaseActivity',s("Catalysis","of","the","reaction",":","deoxynucleoside","triphosphate","+","DNA","(","n",")","=","diphosphate","+","DNA","(","n","+","1",")"),4184290). assertion_content_comment('tOboGo_DNAPackaging',s("Any","process","in","which","DNA","and","associated","proteins","are","formed","into","a","compact",",","orderly","structure","."),4011145). assertion_content_comment('tOboGo_DNAPhotolyaseActivity',s("Catalysis","of","the","repair","of","a","photoproduct","resulting","from","ultraviolet","irradiation","of","two","adjacent","pyrimidine","residues","in","DNA","."),4183918). assertion_content_comment('tOboGo_DNAPolymeraseActivity',s("Catalysis","of","the","reaction",":","deoxynucleoside","triphosphate","+","DNA","(","n",")","=","diphosphate","+","DNA","(","n","+","1",")",";","the","synthesis","of","DNA","from","deoxyribonucleotide","triphosphates","in","the","presence","of","a","nucleic","acid","template","and","primer","."),3974936). assertion_content_comment('tOboGo_DNAPolymeraseBinding',s("Interacting","selectively","and","non-covalently","with","a","DNA","polymerase","."),4179309). assertion_content_comment('tOboGo_DNAPolymeraseComplex',s("A","protein","complex","that","possesses","DNA","polymerase","activity","and","is","involved","in","template","directed","synthesis","of","DNA","."),4007777). assertion_content_comment('tOboGo_DNAPolymeraseIIIComplex',s("A","DNA","polymerase","complex","that","contains","two","complexes","of","the","catalytic","alpha",",","beta",",","delta","and","epsilon","polymerase/exonuclease","subunits",",","plus","the","DnaX","complex",",","a","heptamer","that","includes","the","tau","and","gamma","products","of","the","dnaX","gene","and","confers","structural","asymmetry","that","allows","the","polymerase","to","replicate","both","leading","and","lagging","strands","."),4096572). assertion_content_comment('tOboGo_DNAPolymeraseIIIDnaXComplexChiPsiSubcomplex',s("A","dimer","composed","of","the","chi","and","psi","subunits","which","is","a","subassembly","of","the","DNA","polymerase","III","DnaX","complex","and","serves","as","a","bridge","between","the","DnaX","complex","and","the","single-stranded","DNA-binding","protein","(","SSB",")"),4096589). assertion_content_comment('tOboGo_DNAPolymeraseIIIDnaXComplex',s("A","heptamer","that","includes","the","tau","and","gamma","products","of","the","dnaX","gene","and","the","chi/psi","subcomplex",".","Confers","structural","asymmetry","that","allows","the","polymerase","to","replicate","both","leading","and","lagging","strands","."),4096574). 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assertion_content_comment('tOboGo_DNARepairEnzyme',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193509). assertion_content_comment('tOboGo_DNARepairProtein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193498). assertion_content_comment('tOboGo_DNARepair',s("The","process","of","restoring","DNA","after","damage",".","Genomes","are","subject","to","damage","by","chemical","and","physical","agents","in","the","environment","(","e.g",".","UV","and","ionizing","radiations",",","chemical","mutagens",",","fungal","and","bacterial","toxins",",","etc.",")","and","by","free","radicals","or","alkylating","agents","endogenously","generated","in","metabolism",".","DNA","is","also","damaged","because","of","errors","during","its","replication",".","A","variety","of","different","DNA","repair","pathways","have","been","reported","that","include","direct","reversal",",","base","excision","repair",",","nucleotide","excision","repair",",","photoreactivation",",","bypass",",","double-strand","break","repair","pathway",",","and","mismatch","repair","pathway","."),3976810). 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assertion_content_comment('tOboGo_DNAReplicationFactorAComplex',s("A","conserved","heterotrimeric","complex","that","binds","nonspecifically","to","single-stranded","DNA","and","is","required","for","multiple","processes","in","eukaryotic","DNA","metabolism",",","including","DNA","replication",",","DNA","repair",",","and","recombination",".","In","all","eukaryotic","organisms","examined","the","complex","is","composed","of","subunits","of","approximately","70",",","30",",","and","14","kDa","."),4006664). assertion_content_comment('tOboGo_DNAReplicationFactorCComplex',s("A","complex","of","five","polypeptides","in","eukaryotes",",","and","two","in","prokaryotes",",","that","loads","the","DNA","polymerase","processivity","factor","proliferating","cell","nuclear","antigen","(","PCNA",")","onto","DNA",",","thereby","permitting","processive","DNA","synthesis","catalyzed","by","DNA","polymerase","."),4006741). assertion_content_comment('tOboGo_DNAReplicationFactorCCoreComplex',s("A","protein","complex","containing","three","of","the","five","subunits","of","eukaryotic","replication","factor","C",",","those","corresponding","to","human","p40",",","p38",",","and","p37","."),4131340). assertion_content_comment('tOboGo_DNAReplicationFactor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193520). assertion_content_comment('tOboGo_DNAReplicationInhibitor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4233868). assertion_content_comment('tOboGo_DNAReplicationInvolvedInSPhase',s("The","process","in","which","new","strands","of","genomic","DNA","are","synthesized",",","using","parental","DNA","as","a","template","for","DNA-dependent","DNA","polymerases",",","contributing","to","progression","through","S","phase","of","the","cell","cycle","."),4027793). 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assertion_content_comment('tOboGo_DNAReplicationPreinitiationComplexAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","DNA","replication","preinitiation","complex",",","a","protein-DNA","complex","that","is","assembled","at","eukaryotic","DNA","replication","origins","immediately","prior","to","the","initiation","of","DNA","replication",",","by","the","assembly","of","additional","proteins","onto","an","existing","prereplicative","complex","."),4128745). 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assertion_content_comment('tOboGo_DNAReplicationRemovalOfRNAPrimer',s("Removal","of","the","Okazaki","RNA","primer","from","the","lagging","strand","of","replicating","DNA",",","by","a","combination","of","the","actions","of","DNA","polymerase",",","DNA","helicase","and","an","endonuclease","."),4092948). assertion_content_comment('tOboGo_DNAReplication',s("The","cellular","metabolic","process","in","which","a","cell","duplicates","one","or","more","molecules","of","DNA",".","DNA","replication","begins","when","specific","sequences",",","known","as","origins","of","replication",",","are","recognized","and","bound","by","initiation","proteins",",","and","ends","when","the","original","DNA","molecule","has","been","completely","duplicated","and","the","copies","topologically","separated",".","The","unit","of","replication","usually","corresponds","to","the","genome","of","the","cell",",","an","organelle",",","or","a","virus",".","The","template","for","replication","can","either","be","an","existing","DNA","molecule","or","RNA","."),3979971). assertion_content_comment('tOboGo_DNAReplicationSynthesisOfRNAPrimer',s("The","synthesis","of","a","short","RNA","polymer",",","usually","4-15","nucleotides","long",",","using","one","strand","of","unwound","DNA","as","a","template",";","the","RNA","then","serves","as","a","primer","from","which","DNA","polymerases","extend","synthesis","."),4010913). assertion_content_comment('tOboGo_DNAReplicationTermination',s("The","process","in","which","DNA","replication","at","a","replication","fork","ceases",";","occurs","when","the","replication","fork","reaches","a","specific","termination","site","or","when","two","replication","forks","meet","."),4010851). assertion_content_comment('tOboGo_DNARNAHelicaseActivity',s("Catalysis","of","the","reaction",":","NTP","+","H2O","=","NDP","+","phosphate",";","this","reaction","drives","the","unwinding","of","a","DNA/RNA","duplex",",","i.e",".","a","double","helix","in","which","a","strand","of","DNA","pairs","with","a","complementary","strand","of","RNA","."),4341186). assertion_content_comment('tOboGo_DNARNAHybridBinding',s("Interacting","selectively","and","non-covalently","with","a","RNA/DNA","hybrid","."),4172328). assertion_content_comment('tOboGo_DNASecondaryStructureBinding',s("Interacting","selectively","and","non-covalently","with","DNA","containing","secondary","structure","elements","such","as","four-way","junctions",",","bubbles",",","loops",",","Y-form","DNA",",","or","double-strand/single-strand","junctions","."),4334736). assertion_content_comment('tOboGo_DNASecretionByTheTypeIVSecretionSystem',s("The","controlled","release","of","DNA","by","a","cell",",","via","the","type","IV","secretion","system","."),4288814). assertion_content_comment('tOboGo_DNA',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218424). assertion_content_comment('tOboGo_DNAStrandAnnealingActivity',s("Facilitates","the","base-pairing","of","complementary","single-stranded","DNA","."),4363662). assertion_content_comment('tOboGo_DNAStrandElongationInvolvedInDNAReplication',s("The","process","in","which","a","DNA","strand","is","synthesized","from","template","DNA","during","replication","by","the","action","of","polymerases",",","which","add","nucleotides","to","the","3","'","end","of","the","nascent","DNA","strand","."),4010871). assertion_content_comment('tOboGo_DNAStrandElongation',s("The","DNA","metabolic","process","in","which","a","DNA","strand","is","synthesized","by","adding","nucleotides","to","the","3","'","end","of","an","existing","DNA","stand","."),4010868). assertion_content_comment('tOboGo_DNAStrandRenaturation',s("The","identification","and","annealing","of","complementary","base","pairs","in","single-strand","DNA","."),4134847). assertion_content_comment('tOboGo_DNASupercoilingActivity',s("OBSOLETE",".","Catalysis","of","the","formation","of","positive","or","negative","supercoils","in","a","DNA","molecule","or","region","thereof",";","may","be","associated","with","a","geometric","or","topological","change","in","the","DNA","molecule","."),4355032). assertion_content_comment('tOboGo_DNASynthesisInvolvedInDNARepair',s("Synthesis","of","DNA","that","proceeds","from","the","broken","3","'","single-strand","DNA","end","uses","the","homologous","intact","duplex","as","the","template","."),3977088). assertion_content_comment('tOboGo_DNATopoisomeraseActivity',s("Catalysis","of","the","transient","cleavage","and","passage","of","individual","DNA","strands","or","double","helices","through","one","another",",","resulting","a","topological","transformation","in","double-stranded","DNA","."),4184365). assertion_content_comment('tOboGo_DNATopoisomeraseIBinding',s("Interacting","selectively","and","non-covalently","with","the","enzyme","DNA","topoisomerase","I","."),4268459). assertion_content_comment('tOboGo_DNATopoisomeraseIVActivity',s("OBSOLETE",".","Catalysis","of","the","ATP-independent","breakage","of","DNA",",","followed","by","passage","and","rejoining",".","It","also","catalyzes","the","relaxation","of","supercoiled","DNA",",","and","the","decatenation","and","unknotting","of","DNA","in","vivo","."),4252258). assertion_content_comment('tOboGo_DNATopoisomeraseIVComplex',s("A","heterodimeric","enzyme",",","which","in","most","bacterial","species","is","composed","of","two","subunits",",","ParC","and","ParE",".","Functions","in","chromosome","segregation","and","can","relax","supercoiled","DNA","."),4259581). assertion_content_comment('tOboGo_DNATopoisomeraseTypeIActivity',s("Catalysis","of","a","DNA","topological","transformation","by","transiently","cleaving","one","DNA","strand","at","a","time","to","allow","passage","of","another","strand",";","changes","the","linking","number","by","+","1","per","catalytic","cycle","."),4184367). assertion_content_comment('tOboGo_DNATopologicalChange',s("The","process","in","which","a","transformation","is","induced","in","the","topological","structure","of","a","double-stranded","DNA","helix",",","resulting","in","a","change","in","linking","number","."),4223755). assertion_content_comment('tOboGo_DNATranslocaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",",","to","drive","movement","along","a","single-","or","double-stranded","DNA","molecule","."),4289311). assertion_content_comment('tOboGo_DNATransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","DNA",",","deoxyribonucleic","acid",",","from","one","side","of","a","membrane","to","the","other","."),4286910). assertion_content_comment('tOboGo_DNATransport',s("The","directed","movement","of","RNA",",","deoxyribonucleic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4023857). assertion_content_comment('tOboGo_DNAUnwindingFactor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4306890). assertion_content_comment('tOboGo_DNAUnwindingInvolvedInReplication',s("The","process","in","which","interchain","hydrogen","bonds","between","two","strands","of","DNA","are","broken","or","'","melted","'",",","generating","unpaired","template","strands","for","DNA","replication","."),4010899). assertion_content_comment('tOboGo_DNAViralGenome',s("A","viral","genome","composed","of","deoxyribonucleic","acid","."),4236411). assertion_content_comment('tOboGo_DNAVirusInducedGeneSilencing',s("Gene","silencing","induced","by","DNA","viruses","leading","to","a","sequence-specific","degradation","of","target","mRNAs","or","post-transcriptional","gene","silencing","."),4287424). assertion_content_comment('tOboGo_Doa10pUbiquitinLigaseComplex',s("A","multiprotein","complex","that","recognizes","and","ubiquitinates","membranes","proteins","with","misfolded","cytosolic","domains","during","ER-associated","protein","degradation","(","ERAD",")","In","S",".","cerevisiae",",","this","complex","contains","the","ubiquitin","ligase","Ssm4p/Doa10p","."),4363475). assertion_content_comment('tOboGo_DodecylSulfateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dodecyl","sulfate",",","commonly","found","as","sodium","dodecyl","sulfate","(","SDS",")",",","a","component","of","a","variety","of","synthetic","surfactants","."),4272391). assertion_content_comment('tOboGo_DolicholBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dolichols",",","any","2",",","3-dihydropolyprenol","derived","from","four","or","more","linked","isoprene","units","."),4010089). assertion_content_comment('tOboGo_DolicholKinaseActivity',s("Catalysis","of","the","reaction",":","CTP","+","dolichol","=","CDP","+","dolichyl","phosphate","."),4210629). assertion_content_comment('tOboGo_DolicholMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dolichols",",","any","2",",","3-dihydropolyprenol","derived","from","four","or","more","linked","isoprene","units","."),4010086). assertion_content_comment('tOboGo_DolichyldiphosphataseActivity',s("Catalysis","of","the","reaction",":","dolichyl","diphosphate","+","H2O","=","dolichyl","phosphate","+","phosphate","."),4376115). assertion_content_comment('tOboGo_DolichylDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dolichyl","diphosphate",",","a","diphosphorylated","dolichol","derivative","."),4010108). assertion_content_comment('tOboGo_DolichylDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dolichyl","diphosphate",",","a","diphosphorylated","dolichol","derivative",".","In","eukaryotes",",","these","function","as","carriers","of","mono-","and","oligosaccharide","residues","in","the","glycosylation","of","lipids","and","proteins","within","intracellular","membranes","."),4010104). assertion_content_comment('tOboGo_DolichylMonophosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dolichyl","diphosphate",",","a","phosphorylated","dolichol","derivative","."),4317953). assertion_content_comment('tOboGo_DoliporeSeptum',s("A","septum",",","or","cross-wall",",","between","two","portions","of","a","cell","or","hypha",";","contains","a","central","pore","around","which","the","septum","is","swollen","to","form","a","barrel-shaped","structure",";","pore","is","covered","on","each","side","of","the","septum","by","a","septal","pore","cap","(","parenthosome",")"),4363186). assertion_content_comment('tOboGo_DonorSelection',s("The","process","that","determines","which","donor","locus","a","cell","uses",",","in","preference","to","another",",","in","mating","type","switching","."),4018642). assertion_content_comment('tOboGo_DopachromeIsomeraseActivity',s("Catalysis","of","the","reaction",":","L-dopachrome","=","5",",","6-dihydroxyindole-2-carboxylate","."),4210641). assertion_content_comment('tOboGo_DOPADioxygenaseActivity',s("Catalysis","of","the","4",",","5-ring","opening","reaction",":","3",",","4-dihydroxyphenylalanine","+","O2","=","4",",","5-seco-DOPA",".","4",",","5-seco-DOPA","spontaneously","recyclizes","to","form","betalamic","acid","."),4358766). assertion_content_comment('tOboGo_DopamineBinding',s("Interacting","selectively","and","non-covalently","with","dopamine",",","a","catecholamine","neurotransmitter","formed","by","aromatic-L-amino-acid","decarboxylase","from","3",",","4-dihydroxy-L-phenylalanine","."),4197818). assertion_content_comment('tOboGo_DopamineBiosyntheticProcessFromTyrosine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dopamine","(","3",",","4-dihydroxyphenylethylamine",")","from","L-tyrosine",",","via","the","metabolic","precursor","3",",","4-dihydroxy-L-phenylalanine","(","L-dopa",")","Dopamine","is","a","catecholamine","neurotransmitter","and","a","metabolic","precursor","of","norepinephrine","and","epinephrine","."),4232000). assertion_content_comment('tOboGo_DopamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dopamine",",","a","catecholamine","neurotransmitter","and","a","metabolic","precursor","of","noradrenaline","and","adrenaline","."),4231994). assertion_content_comment('tOboGo_DopamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dopamine",",","a","catecholamine","neurotransmitter","and","a","metabolic","precursor","of","noradrenaline","and","adrenaline","."),4312400). assertion_content_comment('tOboGo_DopamineD1ReceptorActivity',s("A","G-protein","coupled","receptor","that","binds","dopamine","and","has","the","pharmacological","characteristics","of","classic","D1","receptors","."),4360428). assertion_content_comment('tOboGo_DopamineD2ReceptorActivity',s("A","G-protein","coupled","receptor","that","binds","dopamine","and","has","the","pharmacological","characteristics","of","classic","D2","receptors","."),4383643). assertion_content_comment('tOboGo_DopamineD3ReceptorActivity',s("A","G-protein","coupled","receptor","that","binds","dopamine","and","has","the","pharmacological","characteristics","of","classic","D3","receptors","."),4360446). assertion_content_comment('tOboGo_DopamineD4ReceptorActivity',s("A","G-protein","coupled","receptor","that","binds","dopamine","and","has","the","pharmacological","characteristics","of","classic","D4","receptors","."),4360455). assertion_content_comment('tOboGo_DopamineD5ReceptorActivity',s("A","G-protein","coupled","receptor","that","binds","dopamine","and","has","the","pharmacological","characteristics","of","classic","D5","receptors","."),4361403). assertion_content_comment('tOboGo_DopamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dopamine",",","a","catecholamine","neurotransmitter","and","a","metabolic","precursor","of","noradrenaline","and","adrenaline","."),4081645). assertion_content_comment('tOboGo_DopamineReceptorActivityCoupledViaGiGo',s("Combining","with","the","neurotransmitter","dopamine","and","activating","adenylate","cyclase","via","coupling","to","Gi/Go","to","initiate","a","change","in","cell","activity","."),4360437). assertion_content_comment('tOboGo_DopamineReceptorActivityCoupledViaGs',s("Combining","with","the","neurotransmitter","dopamine","and","activating","adenylate","cyclase","via","coupling","to","Gs","to","initiate","a","change","in","cell","activity","."),4360426). assertion_content_comment('tOboGo_DopamineReceptorActivity',s("Combining","with","the","neurotransmitter","dopamine","to","initiate","a","change","in","cell","activity","."),4197820). assertion_content_comment('tOboGo_DopamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","dopamine","receptor","."),4275525). assertion_content_comment('tOboGo_DopamineReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","dopamine","receptor","binding","to","one","of","its","physiological","ligands","."),4108328). assertion_content_comment('tOboGo_DopaminergicNeuronDifferentiation',s("The","process","in","which","a","neuroblast","acquires","the","specialized","structural","and","functional","features","of","a","dopaminergic","neuron",",","a","neuron","that","secretes","dopamine","."),4171433). assertion_content_comment('tOboGo_DopamineSecretion',s("The","regulated","release","of","dopamine","by","a","cell","or","group","of","cells",".","Dopamine","is","a","catecholamine","and","a","precursor","of","adrenaline","and","noradrenaline",".","It","acts","as","a","neurotransmitter","in","the","central","nervous","system","but","it","is","also","produced","peripherally","and","acts","as","a","hormone","."),4039452). 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assertion_content_comment('tOboGo_DuctusVenosusClosure',s("The","morphogenesis","process","in","which","the","ductus","venosus","changes","to","no","longer","permit","blood","flow","after","birth","."),4156155). assertion_content_comment('tOboGo_DUDPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","dUDP",",","deoxyuridine","diphosphate","(","2","'","-deoxy-5","'","-uridylyl","phosphate",")"),4226250). assertion_content_comment('tOboGo_DUDPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dUDP",",","deoxyuridine","(","5","'","-",")","diphosphate","."),4223740). assertion_content_comment('tOboGo_DUDPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dUDP",",","deoxyuridine","(","5","'","-",")","diphosphate","."),4223737). 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assertion_content_comment('tOboGo_DUTPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","dUTP",",","deoxyuridine","(","5","'","-",")","triphosphate","."),4348056). assertion_content_comment('tOboGo_DUTPDiphosphataseActivity',s("Catalysis","of","the","reaction",":","dUTP","+","H2O","=","dUMP","+","diphosphate","."),4210803). assertion_content_comment('tOboGo_DUTPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","dUTP",",","deoxyuridine","(","5","'","-",")","triphosphate","."),4226273). assertion_content_comment('tOboGo_DUTPPyrophosphataseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","dUTP","pyrophosphatase","."),4200220). 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assertion_content_comment('tOboGo_DynaminPolymerizationInvolvedInMitochondrialFission',s("The","process","of","creating","dynamin","polymers",",","compounds","composed","of","a","large","number","of","dynamin","monomers","around","a","lipid","tube","of","a","dividing","mitochondrion",".","Dynamin","polymers","form","around","lipid","tubes","and","contribute","to","membrane","fission","."),4194123). assertion_content_comment('tOboGo_DyneinATPaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",".","The","hydrolysis","of","ATP","by","dynein","that","provides","the","energy","for","the","movement","of","organelles","(","endosomes",",","lysosomes",",","mitochondria",")","along","microtubules","to","the","centrosome","."),4252513). assertion_content_comment('tOboGo_DyneinBinding',s("Interacting","selectively","and","non-covalently","with","dynein",",","the","multisubunit","protein","complex","that","is","associated","with","microtubules","."),4183878). assertion_content_comment('tOboGo_DyneinComplexBinding',s("Interacting","selectively","and","non-covalently","with","a","dynein","complex",",","a","protein","complex","that","contains","two","or","three","dynein","heavy","chains","and","several","light","chains",",","and","has","microtubule","motor","activity","."),4178784). assertion_content_comment('tOboGo_DyneinComplex',s("Any","of","several","large","complexes","that","contain","two","or","three","dynein","heavy","chains","and","several","light","chains",",","and","have","microtubule","motor","activity","."),4221573). assertion_content_comment('tOboGo_DyneinHeavyChainBinding',s("Interacting","selectively","and","non-covalently","with","a","heavy","chain","of","the","dynein","complex","."),4299306). assertion_content_comment('tOboGo_DyneinIntermediateChainBinding',s("Interacting","selectively","and","non-covalently","with","an","intermediate","chain","of","the","dynein","complex","."),4299276). assertion_content_comment('tOboGo_DyneinLightChainBinding',s("Interacting","selectively","and","non-covalently","with","a","light","chain","of","the","dynein","complex","."),4299297). assertion_content_comment('tOboGo_DyneinLightIntermediateChainBinding',s("Interacting","selectively","and","non-covalently","with","a","light","intermediate","chain","of","the","dynein","complex","."),4183880). assertion_content_comment('tOboGo_DystrobrevinComplex',s("A","protein","complex","comprising","alpha-","and","beta-dystrobrevin",";","forms","part","of","the","dystrophin","glycoprotein","complex","."),4033856). assertion_content_comment('tOboGo_DystroglycanBinding',s("Interacting","selectively","and","non-covalently","with","dystroglycan",".","Dystroglycan","is","glycoprotein","found","in","non-muscle","tissues","as","well","as","in","muscle","tissues",",","often","in","association","with","dystrophin",".","The","native","dystroglycan","cleaved","into","two","non-covalently","associated","subunits",",","alpha","(","N-terminal",")","and","beta","(","C-terminal",")"),4375937). assertion_content_comment('tOboGo_DystroglycanComplex',s("A","protein","complex","that","includes","alpha-","and","beta-dystroglycan",",","which","are","alternative","products","of","the","same","gene",";","the","laminin-binding","component","of","the","dystrophin-associated","glycoprotein","complex",",","providing","a","link","between","the","subsarcolemmal","cytoskeleton","(","in","muscle","cells",")","and","the","extracellular","matrix",".","Alpha-dystroglycan","is","an","extracellular","protein","binding","to","alpha-laminin","and","to","beta-dystroglycan",";","beta-dystroglycan","is","a","transmembrane","protein","which","binds","alpha-dystroglycan","and","dystrophin","."),4033822). assertion_content_comment('tOboGo_EarDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","ear","over","time",",","from","its","formation","to","the","mature","structure",".","The","ear","is","the","sense","organ","in","vertebrates","that","is","specialized","for","the","detection","of","sound",",","and","the","maintenance","of","balance",".","Includes","the","outer","ear","and","middle","ear",",","which","collect","and","transmit","sound","waves",";","and","the","inner","ear",",","which","contains","the","organs","of","balance","and","(","except","in","fish",")","hearing",".","Also","includes","the","pinna",",","the","visible","part","of","the","outer","ear",",","present","in","some","mammals","."),3992709). assertion_content_comment('tOboGo_EarlyDistalConvolutedTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","early","distal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","early","distal","convoluted","tubule","contains","DCT","cells","and","is","vasopressin-insensitive","."),4123753). assertion_content_comment('tOboGo_EarlyEndosomeLumen',s("The","volume","enclosed","by","the","membrane","of","an","early","endosome","."),4057263). assertion_content_comment('tOboGo_EarlyEndosomeMembrane',s("The","lipid","bilayer","surrounding","an","early","endosome","."),4057243). assertion_content_comment('tOboGo_EarlyEndosome',s("A","membrane-bounded","organelle","that","receives","incoming","material","from","primary","endocytic","vesicles","that","have","been","generated","by","clathrin-dependent","and","clathrin-independent","endocytosis",";","vesicles","fuse","with","the","early","endosome","to","deliver","cargo","for","sorting","into","recycling","or","degradation","pathways","."),4057233). assertion_content_comment('tOboGo_EarlyEndosomeToGolgiTransport',s("The","directed","movement","of","substances","from","early","endosomes","to","the","Golgi","."),4357461). assertion_content_comment('tOboGo_EarlyEndosomeToLateEndosomeTransport',s("The","directed","movement","of","substances",",","in","membrane-bounded","vesicles",",","from","the","early","sorting","endosomes","to","the","late","sorting","endosomes",";","transport","occurs","along","microtubules","and","can","be","experimentally","blocked","with","microtubule-depolymerizing","drugs","."),4137586). assertion_content_comment('tOboGo_EarlyMeioticRecombinationNoduleAssembly',s("During","meiosis",",","the","aggregation",",","arrangement","and","bonding","together","of","strand","exchange","proteins","(","recombinases",")","to","form","small",",","electron","dense","structures","in","association","with","meiotic","chromosomes","during","leptotene","and","zygotene","."),4314024). assertion_content_comment('tOboGo_EarlyNeuronDifferentiationInForebrain',s("The","process","in","which","neuroepithelial","cells","in","the","neural","tube","acquire","specialized","structural","and/or","functional","features","of","neurons",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","."),4048686). assertion_content_comment('tOboGo_EarlyNeuronFateCommitmentInForebrain',s("The","commitment","of","neuroepithelial","cell","to","become","a","neuron","that","will","reside","in","the","forebrain","."),4048688). assertion_content_comment('tOboGo_EarlyPhagosome',s("A","membrane-bounded","intracellular","vesicle","as","initially","formed","upon","the","ingestion","of","particulate","material","by","phagocytosis","."),4330646). assertion_content_comment('tOboGo_EarlyRecombinationNodule',s("An","electron","dense","structure","that","is","associated","with","meiotic","chromosomes","in","leptotene","or","zygotene","during","meiosis","I","."),4219749). assertion_content_comment('tOboGo_EarlyStripeMelanocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","early","stripe","melanocyte","(","ESM",")","In","zebrafish",",","ESMs","develop","during","the","first","phase","(","2-3","weeks","of","development",")","of","the","larva","to","adult","transition","(","2-4","weeks","of","development",")"),4099922). assertion_content_comment('tOboGo_EarMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","ear","are","generated","and","organized",".","The","ear","is","the","sense","organ","in","vertebrates","that","is","specialized","for","the","detection","of","sound",",","and","the","maintenance","of","balance",".","Includes","the","outer","ear","and","middle","ear",",","which","collect","and","transmit","sound","waves",";","and","the","inner","ear",",","which","contains","the","organs","of","balance","and","(","except","in","fish",")","hearing",".","Also","includes","the","pinna",",","the","visible","part","of","the","outer","ear",",","present","in","some","mammals","."),3992712). assertion_content_comment('tOboGo_EatingBehavior',s("The","specific","actions","or","reactions","of","an","organism","relating","to","the","intake","of","food",",","any","substance","(","usually","solid",")","that","can","be","metabolized","by","an","organism","to","give","energy","and","build","tissue","."),3991003). assertion_content_comment('tOboGo_EcdysiostaticHormoneActivity',s("The","action","characteristic","of","ecdysiostatic","hormone",",","a","peptide","hormone","that","inhibits","ecdysone","secretion","."),4303379). assertion_content_comment('tOboGo_EcdysoneBinding',s("Interacting","selectively","and","non-covalently","with","20-hydroxyecdysone","(","ecdysone",")","Ecdysone","is","an","ecdysteroid","produced","by","the","prothoracic","glands","of","immature","insects","and","the","ovaries","of","adult","females",",","which","stimulates","growth","and","molting","."),4381908). 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assertion_content_comment('tOboGo_EcdysoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ecdysone",",","(","22R",")","-2-beta",",","3-beta",",","14",",","22",",","25-pentahydroxycholest-7-en-6-one",",","an","ecdysteroid","found","in","insects",".","It","is","the","inactive","prohormone","of","the","moulting","hormone","ecdysterone","and","may","have","intrinsic","hormonal","activity","at","other","stages","of","insect","development","."),4229592). assertion_content_comment('tOboGo_EcdysoneModification',s("OBSOLETE",".","The","covalent","or","conformational","alteration","of","ecdysone",",","resulting","in","a","change","in","its","properties","."),4231063). assertion_content_comment('tOboGo_EcdysoneOxidaseActivity',s("Catalysis","of","the","reaction",":","Ecdysone","+","O","(","2",")","=","3-dehydroecdysone","+","H","(","2",")","O","(","2",")"),4376232). assertion_content_comment('tOboGo_EcdysoneReceptorHolocomplex',s("A","heterodimeric","complex","containing","the","products","of","the","insect","genes","Ecdysone","receptor","(","EcR",")","and","ultraspiracle","(","usp",")","Binding","of","ecdysone","promotes","association","between","the","two","subunits",",","and","the","receptor","complex","then","initiates","molting","and","metamorphosis","by","binding","DNA","and","regulating","the","transcription","of","target","genes","."),4255892). assertion_content_comment('tOboGo_EcdysteroidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ecdysteroids",",","a","group","of","polyhydroxylated","ketosteroids","which","initiate","post-embryonic","development","."),4015804). assertion_content_comment('tOboGo_EcdysteroidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ecdysteroids",",","a","group","of","polyhydroxylated","ketosteroids","which","initiate","post-embryonic","development","."),4229621). assertion_content_comment('tOboGo_EcdysteroidHormoneReceptorActivity',s("Combining","with","ecdysteroid","hormone","to","initiate","a","change","in","cell","activity","."),4200073). assertion_content_comment('tOboGo_EcdysteroidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ecdysteroids",",","a","group","of","polyhydroxylated","ketosteroids","ubiquitous","in","insects","and","other","arthropods",",","in","which","they","initiate","post-embryonic","development",",","including","the","metamorphosis","of","immature","forms","and","the","development","of","the","reproductive","system","and","the","maturation","of","oocytes","in","adult","females","."),4015801). assertion_content_comment('tOboGo_EcdysteroidSecretion',s("The","regulated","release","of","ecdysteroids",",","a","group","of","polyhydroxylated","ketosteroids","which","initiate","post-embryonic","development","."),4015725). assertion_content_comment('tOboGo_Echolocation',s("Echolocation","is","the","method","used","by","some","animals","(","e.g",".","bats",",","dolphins","and","some","whales",")","to","determine","the","location","of","something","by","measuring","the","time","it","takes","for","an","echo","to","return","from","it",".","These","animals","emit","sound","waves","and","listen","for","the","echo",",","calculating","the","distance","to","the","object","from","the","time","lapse","between","sound","emission","and","the","echo","returning","."),4100364). 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assertion_content_comment('tOboGo_EctodermalCellFateSpecification',s("The","cell","fate","determination","process","that","results","in","a","cell","becoming","becomes","capable","of","differentiating","autonomously","into","an","ectoderm","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),3982623). assertion_content_comment('tOboGo_EctodermalDigestiveTractDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","ectodermal","digestive","tract","over","time",",","from","its","formation","to","the","mature","structure",".","The","ectodermal","digestive","tract","includes","those","portions","that","are","derived","from","ectoderm","."),4017651). assertion_content_comment('tOboGo_EctodermalDigestiveTractMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","ectodermal","digestive","tract","are","generated","and","organized",".","The","ectodermal","digestive","tract","includes","those","portions","of","the","digestive","tract","that","are","derived","from","ectoderm","."),4017655). assertion_content_comment('tOboGo_EctodermalPlacodeDevelopment',s("The","progression","of","an","ectodermal","placode","over","time","from","its","initial","formation","until","its","mature","state",".","An","ectodermal","placode","is","a","thickening","of","the","ectoderm","that","is","the","primordium","of","many","structures","derived","from","the","ectoderm","."),3985290). 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assertion_content_comment('tOboGo_ElaioplastOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","elaioplast",",","a","leucoplast","in","which","oil","is","stored","."),4325651). assertion_content_comment('tOboGo_Elaioplast',s("A","leucoplast","in","which","oil","is","stored","."),4022967). assertion_content_comment('tOboGo_ElaioplastStroma',s("The","space","enclosed","by","the","double","membrane","of","an","elaioplast","."),4022977). assertion_content_comment('tOboGo_ElastaseActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","elastin","."),4316870). assertion_content_comment('tOboGo_ElasticFiberAssembly',s("Assembly","of","the","extracellular","matrix","fibers","that","enables","the","matrix","to","recoil","after","transient","stretching","."),4384931). assertion_content_comment('tOboGo_ElasticFiber',s("An","extracellular","matrix","part","that","consists","of","an","insoluble","core","of","polymerized","tropoelastin","monomers","and","a","surrounding","mantle","of","microfibrils",".","Elastic","fibers","provide","elasticity","and","recoiling","to","tissues","and","organs",",","and","maintain","structural","integrity","against","mechanical","strain","."),4168748). assertion_content_comment('tOboGo_ElastinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","elastin",",","a","fibrous","glycoprotein","found","in","elastic","tissues","such","as","the","walls","of","arteries","."),4118802). 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assertion_content_comment('tOboGo_ElectronTransferCarrier',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4272924). assertion_content_comment('tOboGo_ElectronTransferFlavoproteinComplex',s("A","protein","complex","containing","flavin","adenine","dinucleotide","(","FAD",")","and","acyl-CoA","dehydrogenase",",","which","form","a","system","that","oxidizes","an","acyl-CoA","molecule","and","reduces","ubiquinone","and","other","acceptors","in","the","mitochondrial","electron","transport","system","."),4040933). assertion_content_comment('tOboGo_ElectronTransferFlavoproteinGroupII',s("OBSOLETE",".","An","electron","transfer","flavoprotein","that","functions","as","a","housekeeping","protein","that","is","synthesized","only","under","certain","specific","growth","conditions","and","receives","electrons","from","the","oxidation","of","specific","substrates",",","e.g",".","trimethylamine",",","carnitine","and","in","nitrogen","fixation","."),4296872). assertion_content_comment('tOboGo_ElectronTransferFlavoproteinGroupI',s("OBSOLETE",".","An","electron","transfer","flavoprotein","that","functions","as","a","housekeeping","protein","that","links","acyl-CoA","dehydrogenase","reactions","with","the","respiratory","chain",",","such","as","in","the","fatty","acid","degradation","pathway","."),4296900). assertion_content_comment('tOboGo_ElectronTransferFlavoprotein',s("OBSOLETE",".","Works","in","conjunction","with","acyl-CoA","dehydrogenase","to","catalyze","the","oxidation","of","CoA","and","reduce","ubiquinone",".","Part","of","the","mitochondrial","electron","transport","system","."),4255916). assertion_content_comment('tOboGo_ElectronTransportChain',s("A","process","in","which","a","series","of","electron","carriers","operate","together","to","transfer","electrons","from","donors","to","any","of","several","different","terminal","electron","acceptors","to","generate","a","transmembrane","electrochemical","gradient","."),4010634). assertion_content_comment('tOboGo_ElectronTransportCoupledProtonTransport',s("The","transport","of","protons","against","an","electrochemical","gradient",",","using","energy","from","electron","transport","."),4295087). assertion_content_comment('tOboGo_ElectronTransporterActivity',s("OBSOLETE",".","Enables","the","directed","movement","of","electrons","into",",","out","of",",","within","or","between","cells","."),4219398). assertion_content_comment('tOboGo_ElectronTransporterTransferringElectronsFromCytochromeB6FComplexOfPhotosystemIIActivity',s("Enables","the","directed","movement","of","electrons","from","the","cytochrome","b6/f","complex","of","photosystem","II","."),4296634). assertion_content_comment('tOboGo_ElectronTransporterTransferringElectronsWithinCytochromeB6FComplexOfPhotosystemIIActivity',s("Enables","the","directed","movement","of","electrons","within","the","cytochrome","b6/f","complex","of","photosystem","II","."),4259012). assertion_content_comment('tOboGo_ElectronTransporterTransferringElectronsWithinCytochromeCOxidaseComplexActivity',s("Enables","the","directed","movement","of","electrons","within","the","cytochrome","c","oxidase","complex","."),4259104). assertion_content_comment('tOboGo_ElectronTransporterTransferringElectronsWithinTheCyclicElectronTransportPathwayOfPhotosynthesisActivity',s("Enables","the","directed","movement","of","electrons","within","the","cyclic","electron","transport","pathway","of","photosynthesis","."),4259131). assertion_content_comment('tOboGo_ElectronTransporterTransferringElectronsWithinTheNoncyclicElectronTransportPathwayOfPhotosynthesisActivity',s("Enables","the","directed","movement","of","electrons","within","the","noncyclic","electron","transport","pathway","of","photosynthesis","."),4259143). assertion_content_comment('tOboGo_ElectronTransport',s("OBSOLETE",".","The","transport","of","electrons","from","an","electron","donor","to","an","electron","acceptor","."),4224317). assertion_content_comment('tOboGo_ElectrosensoryLateralLineSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","electrosensory","lateral","line","system","over","time",",","from","its","formation","to","the","mature","structure","."),4329038). assertion_content_comment('tOboGo_ElevationOfCytosolicCalciumIonConcentrationInvolvedInEggActivation',s("The","process","that","increases","the","concentration","of","calcium","ions","in","the","cytosol","after","fertilization","or","the","physiological","activation","of","an","egg","."),4117907). assertion_content_comment('tOboGo_ElevationOfCytosolicCalciumIonConcentration',s("Any","process","that","increases","the","concentration","of","calcium","ions","in","the","cytosol","."),4029686). assertion_content_comment('tOboGo_ElevationOfEndoplasmicReticulumCalciumIonConcentration',s("Any","process","that","increases","the","concentration","of","calcium","ions","in","the","endoplasmic","reticulum","."),4284020). assertion_content_comment('tOboGo_ElevationOfMitochondrialCalciumIonConcentration',s("Any","process","that","increases","the","concentration","of","calcium","ions","in","mitochondria","."),4283972). assertion_content_comment('tOboGo_ElevationOfSmoothEndoplasmicReticulumCalciumIonConcentration',s("Any","process","that","increases","the","concentration","of","calcium","ions","in","the","smooth","endoplasmic","reticulum","."),4284026). assertion_content_comment('tOboGo_ElongationOfAristaCore',s("The","increase","in","length","of","the","aristal","core",".","The","arista","is","the","terminal","segment","of","the","antenna","and","consists","of","a","central","core","and","a","series","of","lateral","extensions","."),4072521). assertion_content_comment('tOboGo_ElongationOfAristaLateral',s("The","increase","in","length","of","the","aristal","laterals",".","The","arista","is","the","terminal","segment","of","the","antenna","and","consists","of","a","central","core","and","a","series","of","lateral","extensions","."),4072511). assertion_content_comment('tOboGo_ElongatorHoloenzymeComplex',s("A","heterohexameric","protein","complex","that","is","involved","in","tRNA","modification",",","and","exerts","indirect","effects","on","transcriptional","elongation","and","exocytosis",".","The","complex","can","associate","physically","with","hyperphosphorylated","RNA","polymerase","II",";","it","contains","two","discrete","heterotrimeric","subcomplexes","."),4340449). assertion_content_comment('tOboGo_ElonginComplex',s("A","transcription","elongation","factor","complex","that","suppresses","RNA","polymerase","II","pausing",",","and","may","act","by","promoting","proper","alignment","of","the","3","'","-end","of","nascent","transcripts","with","the","polymerase","catalytic","site",".","Consists","of","a","transcriptionally","active","Elongin","A","subunit","(","abut","100","kDa",")","and","two","smaller","Elongin","B","(","about","18","kDa",")","and","Elongin","C","(","about","15","kDa",")","subunits","."),4175336). assertion_content_comment('tOboGo_EmboliformNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","emboliform","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042554). assertion_content_comment('tOboGo_EmbryoDevelopmentEndingInBirthOrEggHatching',s("The","process","whose","specific","outcome","is","the","progression","of","an","embryo","over","time",",","from","zygote","formation","until","the","end","of","the","embryonic","life","stage",".","The","end","of","the","embryonic","life","stage","is","organism-specific","and","may","be","somewhat","arbitrary",";","for","mammals","it","is","usually","considered","to","be","birth",",","for","insects","the","hatching","of","the","first","instar","larva","from","the","eggshell","."),3985156). assertion_content_comment('tOboGo_EmbryoDevelopmentEndingInSeedDormancy',s("The","process","whose","specific","outcome","is","the","progression","of","the","embryo","over","time",",","from","zygote","formation","to","the","end","of","seed","dormancy",".","An","example","of","this","process","is","found","in","Arabidopsis","thaliana","."),4022255). assertion_content_comment('tOboGo_EmbryoDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","embryo","from","its","formation","until","the","end","of","its","embryonic","life","stage",".","The","end","of","the","embryonic","stage","is","organism-specific",".","For","example",",","for","mammals",",","the","process","would","begin","with","zygote","formation","and","end","with","birth",".","For","insects",",","the","process","would","begin","at","zygote","formation","and","end","with","larval","hatching",".","For","plant","zygotic","embryos",",","this","would","be","from","zygote","formation","to","the","end","of","seed","dormancy",".","For","plant","vegetative","embryos",",","this","would","be","from","the","initial","determination","of","the","cell","or","group","of","cells","to","form","an","embryo","until","the","point","when","the","embryo","becomes","independent","of","the","parent","plant","."),3982038). assertion_content_comment('tOboGo_EmbryogenesisAndMorphogenesis',s("OBSOLETE",".","Formation","and","development","of","an","embryo","and","its","organized","structures","."),4234595). assertion_content_comment('tOboGo_EmbryoImplantation',s("Attachment","of","the","blastocyst","to","the","uterine","lining","."),4015333). assertion_content_comment('tOboGo_EmbryonicAnalFinMorphogenesis',s("The","process",",","occurring","in","the","embryo",",","by","which","the","anatomical","structures","of","the","embryonic","anal","fin","are","generated","and","organized",".","An","anal","fin","is","an","unpaired","medial","fin","on","the","ventral","aspect","near","the","caudal","end","of","a","fish",",","which","provides","lateral","stability","while","swimming","."),4382251). assertion_content_comment('tOboGo_EmbryonicAnteriorMidgutEctodermalMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","anterior","midgut","(","ectodermal",")","are","generated","and","organized",",","during","the","embryonic","phase","."),4106470). assertion_content_comment('tOboGo_EmbryonicAppendageMorphogenesis',s("The","process",",","occurring","in","the","embryo",",","by","which","the","anatomical","structures","of","the","appendage","are","generated","and","organized",".","An","appendage","is","an","organ","or","part","that","is","attached","to","the","trunk","of","an","organism",",","such","as","a","limb","or","a","branch","."),4077209). assertion_content_comment('tOboGo_EmbryonicArmMorphogenesis',s("The","process",",","occurring","in","the","embryo",",","by","which","the","anatomical","structures","of","the","arm","are","generated","and","organized",".","In","humans",",","the","arms","are","the","two","upper","limbs","of","the","body","from","the","shoulder","to","the","hand","."),4382321). assertion_content_comment('tOboGo_EmbryonicAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","a","pattern","along","a","line","or","a","point","in","an","embryo","."),4018924). assertion_content_comment('tOboGo_EmbryonicBodyMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","embryonic","soma","are","generated","and","organized","."),4136032). 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assertion_content_comment('tOboGo_EmbryonicOlfactoryBulbInterneuronPrecursorMigration',s("The","directed","movement","of","individual","interneuron","precursors","during","the","embryonic","development","of","the","olfactory","bulb","."),4051095). assertion_content_comment('tOboGo_EmbryonicOrganDevelopment',s("Development",",","taking","place","during","the","embryonic","phase",",","of","a","tissue","or","tissues","that","work","together","to","perform","a","specific","function","or","functions",".","Development","pertains","to","the","process","whose","specific","outcome","is","the","progression","of","a","structure","over","time",",","from","its","formation","to","the","mature","structure",".","Organs","are","commonly","observed","as","visibly","distinct","structures",",","but","may","also","exist","as","loosely","associated","clusters","of","cells","that","work","together","to","perform","a","specific","function","or","functions","."),3986660). 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assertion_content_comment('tOboGo_EndocardialCushionDevelopment',s("The","progression","of","a","cardiac","cushion","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","endocardial","cushion","is","a","specialized","region","of","mesenchymal","cells","that","will","give","rise","to","the","heart","septa","and","valves","."),4001144). assertion_content_comment('tOboGo_EndocardialCushionFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","an","endocardial","cushion",".","The","endocardial","cushion","is","a","specialized","region","of","mesenchymal","cells","that","will","give","rise","to","the","heart","septa","and","valves","."),4001156). assertion_content_comment('tOboGo_EndocardialCushionFusion',s("The","cell-cell","adhesion","process","of","mesenchymal","cardiac","cushion","cells","that","contributes","to","the","process","of","cushion","shaping","."),4001494). assertion_content_comment('tOboGo_EndocardialCushionMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","endocardial","cushion","is","generated","and","organized",".","The","endocardial","cushion","is","a","specialized","region","of","mesenchymal","cells","that","will","give","rise","to","the","heart","septa","and","valves","."),4001146). assertion_content_comment('tOboGo_EndocardialCushionToMesenchymalTransitionInvolvedInCardiacSkeletonDevelopment',s("A","transition","where","an","endocardial","cushion","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","that","will","give","rise","to","the","cardiac","skeleton","."),4002489). assertion_content_comment('tOboGo_EndocardialCushionToMesenchymalTransitionInvolvedInHeartChamberSeptation',s("A","transition","where","an","endocardial","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","that","will","contribute","to","the","formation","of","the","heart","septum","."),4002468). assertion_content_comment('tOboGo_EndocardialCushionToMesenchymalTransitionInvolvedInValveFormation',s("A","transition","where","an","endocardial","cushion","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","that","will","contribute","to","the","formation","of","a","cardiac","valve","."),4002509). assertion_content_comment('tOboGo_EndocardialEndotheliumDevelopment',s("The","progression","of","the","endocardial","endothelium","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","endocardium","is","an","anatomical","structure","comprised","of","an","endothelium","and","an","extracellular","matrix","that","forms","the","innermost","layer","of","tissue","of","the","heart",",","and","lines","the","heart","chambers","."),4135628). assertion_content_comment('tOboGo_EndocardialPrecursorCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","mesodermal","cell","acquires","the","specialized","structural","and/or","functional","features","of","an","endocardial","precursor","cell",".","A","endocardial","precursor","cell","is","a","cell","that","has","been","committed","to","a","endocardial","cell","fate",",","but","will","undergo","further","cell","divisions","rather","than","terminally","differentiate","."),4003165). assertion_content_comment('tOboGo_EndocardialProgenitorCellMigrationToTheMidlineInvolvedInHeartFieldFormation',s("The","orderly","movement","of","an","endocardial","progenitor","cell","toward","the","midline","to","form","the","heart","field",".","Cardiac","muscle","progenitor","cells","are","non-terminally","differentiated",",","mesoderm-derived","cells","that","are","committed","to","differentiate","into","endocardial","cells","of","the","heart","."),4194292). assertion_content_comment('tOboGo_EndocardiumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","endocardium","over","time",",","from","its","formation","to","the","mature","structure",".","The","endocardium","is","an","anatomical","structure","comprised","of","an","endothelium","and","an","extracellular","matrix","that","forms","the","innermost","layer","of","tissue","of","the","heart",",","and","lines","the","heart","chambers","."),4003558). assertion_content_comment('tOboGo_EndocardiumFormation',s("Formation","of","the","endocardium","of","the","heart",".","The","endocardium","is","an","anatomical","structure","comprised","of","an","endothelium","and","an","extracellular","matrix","that","forms","the","innermost","layer","of","tissue","of","the","heart",",","and","lines","the","heart","chambers","."),4115498). assertion_content_comment('tOboGo_EndocardiumMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","endocardium","is","generated","and","organized",".","The","endocardium","is","an","anatomical","structure","comprised","of","an","endothelium","and","an","extracellular","matrix","that","forms","the","innermost","layer","of","tissue","of","the","heart",",","and","lines","the","heart","chambers","."),4003568). assertion_content_comment('tOboGo_EndochitinaseActivity',s("Catalysis","of","the","hydrolysis","of","nonterminal","1",",","4-beta-linkages","of","N-acetyl-D-glucosamine","polymers","of","chitin","and","chitodextrins","."),4249892). assertion_content_comment('tOboGo_EndochondralBoneGrowth',s("The","increase","in","size","or","mass","of","an","endochondral","bone","that","contributes","to","the","shaping","of","the","bone","."),4004182). assertion_content_comment('tOboGo_EndochondralBoneMorphogenesis',s("The","process","in","which","bones","are","generated","and","organized","as","a","result","of","the","conversion","of","initial","cartilaginous","anlage","into","bone","."),3987840). assertion_content_comment('tOboGo_EndocrineHormoneSecretion',s("The","regulated","release","of","a","hormone","into","the","circulatory","system","."),4015383). assertion_content_comment('tOboGo_EndocrinePancreasDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","endocrine","pancreas","over","time",",","from","its","formation","to","the","mature","structure",".","The","endocrine","pancreas","is","made","up","of","islet","cells","that","produce","insulin",",","glucagon","and","somatostatin","."),4001945). assertion_content_comment('tOboGo_EndocrineProcess',s("The","process","that","involves","the","secretion","of","or","response","to","endocrine","hormones",".","An","endocrine","hormone","is","a","hormone","released","into","the","circulatory","system","."),3973418). assertion_content_comment('tOboGo_EndocrineSignaling',s("The","transfer","of","information","from","one","cell","to","another",",","where","an","endocrine","hormone","is","transported","from","the","signal-producing","cell","to","the","receiving","cell","via","the","circulatory","system","(","via","blood",",","lymph","or","cerebrospinal","fluid",")","The","signaling","cell","and","the","receiving","cell","are","often","distant","to","each","other","."),3973422). assertion_content_comment('tOboGo_EndocrineSystemDevelopment',s("Progression","of","the","endocrine","system","over","time",",","from","its","formation","to","a","mature","structure",".","The","endocrine","system","is","a","system","of","hormones","and","ductless","glands",",","where","the","glands","release","hormones","directly","into","the","blood",",","lymph","or","other","intercellular","fluid",",","and","the","hormones","circulate","within","the","body","to","affect","distant","organs",".","The","major","glands","that","make","up","the","human","endocrine","system","are","the","hypothalamus",",","pituitary",",","thyroid",",","parathryoids",",","adrenals",",","pineal","body",",","and","the","reproductive","glands","which","include","the","ovaries","and","testes","."),4001943). assertion_content_comment('tOboGo_EndocyticRecycling',s("The","directed","movement","of","membrane-bounded","vesicles","from","recycling","endosomes","back","to","the","plasma","membrane","where","they","are","recycled","for","further","rounds","of","transport","."),4334774). assertion_content_comment('tOboGo_EndocyticVesicleLumen',s("The","volume","enclosed","by","the","membrane","of","an","endocytic","vesicle","."),4073761). assertion_content_comment('tOboGo_EndocyticVesicleMembrane',s("The","lipid","bilayer","surrounding","an","endocytic","vesicle","."),4051691). assertion_content_comment('tOboGo_EndocyticVesicle',s("A","membrane-bounded","intracellular","vesicle","formed","by","invagination","of","the","plasma","membrane","around","an","extracellular","substance",".","Endocytic","vesicles","fuse","with","early","endosomes","to","deliver","the","cargo","for","further","sorting","."),4051648). assertion_content_comment('tOboGo_EndocytosedProteinTransportToVacuole',s("The","directed","movement","of","proteins","imported","into","a","cell","by","endocytosis","to","the","vacuole","."),4235316). assertion_content_comment('tOboGo_EndocytoticTransportVesicle',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4221396). assertion_content_comment('tOboGo_EndodeoxyribonucleaseActivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","deoxyribonucleic","acid","by","creating","internal","breaks","."),4204802). assertion_content_comment('tOboGo_EndodermalCellFateCommitment',s("The","cell","differentiation","process","that","results","in","commitment","of","a","cell","to","become","part","of","the","endoderm","."),3982634). assertion_content_comment('tOboGo_EndodermalCellFateDetermination',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","endoderm","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4018209). assertion_content_comment('tOboGo_EndodermalCellFateSpecification',s("The","cell","fate","determination","process","that","results","in","a","cell","becoming","capable","of","differentiating","autonomously","into","an","endoderm","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),3982645). assertion_content_comment('tOboGo_EndodermalDigestiveTractMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","endodermal","digestive","tract","are","generated","and","organized",".","The","endodermal","digestive","tract","includes","those","portions","of","the","digestive","tract","that","are","derived","from","endoderm","."),4155828). assertion_content_comment('tOboGo_EndodermDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","endoderm","over","time",",","from","its","formation","to","the","mature","structure",".","The","endoderm","is","the","innermost","germ","layer","that","develops","into","the","gastrointestinal","tract",",","the","lungs","and","associated","tissues","."),3982112). assertion_content_comment('tOboGo_EndodermFormation',s("The","formation","of","the","endoderm","during","gastrulation","."),3982122). assertion_content_comment('tOboGo_EndogalactosaminidaseActivity',s("Catalysis","of","the","endohydrolysis","of","1",",","4-alpha-D-galactosaminidic","linkages","in","poly","(","D-galactosamine",")"),4344799). assertion_content_comment('tOboGo_EndogenousAntibioticCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","an","antibiotic","that","has","originated","internally","within","the","cell","or","organism","."),4316937). assertion_content_comment('tOboGo_EndogenousDrugCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","drug","that","has","originated","internally","within","the","cell","or","organism","."),4316890). assertion_content_comment('tOboGo_EndogenousLipidAntigenBinding',s("Interacting","selectively","and","non-covalently","with","an","endogenous","cellular","lipid","antigen","."),4307130). assertion_content_comment('tOboGo_EndogenousPeptideReceptorActivity',s("OBSOLETE",".","Combining","with","an","intracellular","peptide","to","initiate","a","change","in","cell","activity","."),4254976). assertion_content_comment('tOboGo_EndoglycosylceramidaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","oligoglycosylglucosylceramide","=","ceramide","+","oligoglycosylglucose","."),4376218). assertion_content_comment('tOboGo_EndomembraneSystemOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","endomembrane","system","."),4103117). assertion_content_comment('tOboGo_EndomembraneSystem',s("A","collection","of","membranous","structures","involved","in","transport","within","the","cell",".","The","main","components","of","the","endomembrane","system","are","endoplasmic","reticulum",",","Golgi","bodies",",","vesicles",",","cell","membrane","and","nuclear","envelope",".","Members","of","the","endomembrane","system","pass","materials","through","each","other","or","though","the","use","of","vesicles","."),3971979). assertion_content_comment('tOboGo_EndomitoticCellCycle',s("A","mitotic","cell","cycle","in","which","chromosomes","are","replicated","and","sister","chromatids","separate",",","but","spindle","formation",",","nuclear","membrane","breakdown","and","nuclear","division","do","not","occur",",","resulting","in","an","increased","number","of","chromosomes","in","the","cell","."),4236059). assertion_content_comment('tOboGo_EndonucleaseActivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","nucleic","acids","by","creating","internal","breaks","."),4174696). assertion_content_comment('tOboGo_EndonucleaseGActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236506). assertion_content_comment('tOboGo_EndonucleaseVIIIActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4249883). assertion_content_comment('tOboGo_EndonucleolyticCleavageInvolvedInRRNAProcessing',s("Any","endonucleolytic","cleavage","involved","in","the","conversion","of","a","primary","ribosomal","RNA","(","rRNA",")","transcript","into","a","mature","rRNA","molecule",".","Some","endonucleolytic","cleavages","produce","the","mature","end",",","while","others","are","a","step","in","the","process","of","generating","the","mature","end","from","the","pre-rRNA","."),3976209). assertion_content_comment('tOboGo_EndopeptidaseActivatorActivity',s("Increases","the","activity","of","an","endopeptidase",",","any","enzyme","that","hydrolyzes","nonterminal","peptide","bonds","in","polypeptides","."),4156049). assertion_content_comment('tOboGo_EndopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","internal",",","alpha-peptide","bonds","in","a","polypeptide","chain","."),4179623). assertion_content_comment('tOboGo_EndopeptidaseClpActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","proteins","to","small","peptides","in","the","presence","of","ATP","and","magnesium",".","Alpha-casein","is","the","usual","test","substrate",".","In","the","absence","of","ATP",",","only","oligopeptides","shorter","than","five","residues","are","cleaved",",","for","example",",","succinyl-Leu-Tyr-NHMec","which","is","cleaved","at","the","Tyr-NHMec","bond",",","and","Leu-Tyr-Leu-Tyr-Trp","which","is","cleaved","at","the","second","Leu-Typ","bond","(","cleavage","of","the","Tyr-Leu","and","Tyr-Trp","bonds","also","occurs",")"),4254061). assertion_content_comment('tOboGo_EndopeptidaseClpComplex',s("A","protein","complex","comprised","of","members","of","the","ClpX",",","ClpC",",","ClpD",",","ClpP","or","ClpR","protein","families",".","ClpPs","are","the","proteolytic","subunit","of","active","complexes",",","and","ClpA","and","ClpX","form","the","regulatory","subunits",".","Enzymatically","active","and","inactive","complexes","can","form","."),4021615). assertion_content_comment('tOboGo_EndopeptidaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","an","endopeptidase",",","any","enzyme","that","hydrolyzes","nonterminal","peptide","bonds","in","polypeptides","."),4200350). assertion_content_comment('tOboGo_EndopeptidaseLaActivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","large","proteins","such","as","globin",",","casein","and","denatured","serum","albumin",",","in","presence","of","ATP","."),4249824). assertion_content_comment('tOboGo_EndopeptidaseRegulatorActivity',s("Modulates","the","activity","of","a","peptidase",",","any","enzyme","that","hydrolyzes","nonterminal","peptide","bonds","in","polypeptides","."),4156017). assertion_content_comment('tOboGo_EndoplasmicReticulumCalciumIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","calcium","ions","within","the","endoplasmic","reticulum","of","a","cell","or","between","the","endoplasmic","reticulum","and","its","surroundings","."),4283943). assertion_content_comment('tOboGo_EndoplasmicReticulumChaperoneComplex',s("A","protein","complex","that","is","located","in","the","endoplasmic","reticulum","and","is","composed","of","chaperone","proteins",",","including","BiP",",","GRP94",";","CaBP1",",","protein","disulfide","isomerase","(","PDI",")",",","ERdj3",",","cyclophilin","B",",","ERp72",",","GRP170",",","UDP-glucosyltransferase",",","and","SDF2-L1","."),4354498). assertion_content_comment('tOboGo_EndoplasmicReticulumCisternalNetworkAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","endoplasmic","reticulum","(","ER",")","cisternal","network",".","The","ER","cisternal","network","is","the","ER","part","that","comprises","the","membranes","with","low","curvature","in","cross-section","."),4169188). assertion_content_comment('tOboGo_EndoplasmicReticulumCisternalNetworkMaintenance',s("The","organization","process","that","preserves","the","endoplasmic","reticulum","(","ER",")","cisternal","network","in","a","stable","functional","or","structural","state",".","The","ER","cisternal","network","is","the","ER","part","that","comprises","the","membranes","with","low","curvature","in","cross-section","."),4169177). assertion_content_comment('tOboGo_EndoplasmicReticulumCisternalNetworkOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","endoplasmic","reticulum","(","ER",")","cisternal","network",".","The","ER","cisternal","network","is","the","ER","part","that","comprises","the","membranes","with","low","curvature","in","cross-section","."),4169171). assertion_content_comment('tOboGo_EndoplasmicReticulumCisternalNetwork',s("An","endoplasmic","reticulum","part","that","comprises","the","membranes","with","low","curvature","in","cross-section","."),4169425). assertion_content_comment('tOboGo_EndoplasmicReticulumExitSite',s("An","endoplasmic","reticulum","part","at","which","COPII-coated","vesicles","are","produced","."),4177709). assertion_content_comment('tOboGo_EndoplasmicReticulumInheritance',s("The","partitioning","of","endoplasmic","reticulum","between","daughter","cells","at","cell","division","."),4334580). assertion_content_comment('tOboGo_EndoplasmicReticulumLocalizationInvolvedInEndoplasmicReticulumPolarizationAtCellDivisionSite',s("The","process","in","which","endoplasmic","reticulum","is","transiently","localized","to","the","site","where","a","cell","will","divide","."),4135738). assertion_content_comment('tOboGo_EndoplasmicReticulumLocalization',s("Any","process","in","which","endoplasmic","reticulum","is","transported","to",",","and/or","maintained","in",",","a","specific","location","within","the","cell","."),4121966). assertion_content_comment('tOboGo_EndoplasmicReticulumMembraneFusion',s("The","joining","of","2","or","more","lipid","bilayer","membranes","that","surround","the","endoplasmic","reticulum","."),4304316). assertion_content_comment('tOboGo_EndoplasmicReticulumMembraneOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","endoplasmic","reticulum","membrane","."),4149245). assertion_content_comment('tOboGo_EndoplasmicReticulumOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","endoplasmic","reticulum","."),4097125). assertion_content_comment('tOboGo_EndoplasmicReticulumPalmitoyltransferaseComplex',s("A","dimeric","complex","of","the","endoplasmic","reticulum","that","catalyzes","S-palmitoylation",",","the","addition","of","palmitate","(","C16",":","0",")","or","other","long-chain","fatty","acids","to","proteins","at","a","cysteine","residue","."),4062283). assertion_content_comment('tOboGo_EndoplasmicReticulumPart',s("Any","constituent","part","of","the","endoplasmic","reticulum",",","the","irregular","network","of","unit","membranes",",","visible","only","by","electron","microscopy",",","that","occurs","in","the","cytoplasm","of","many","eukaryotic","cells",".","The","membranes","form","a","complex","meshwork","of","tubular","channels",",","which","are","often","expanded","into","slitlike","cavities","called","cisternae","."),3978849). assertion_content_comment('tOboGo_EndoplasmicReticulumPolarization',s("The","endoplasmic","reticulum","organization","process","that","results","in","the","structure","of","the","endoplasmic","reticulum","being","oriented","in","the","cell","."),4135726). assertion_content_comment('tOboGo_EndoplasmicReticulumQualityControlCompartment',s("A","subcompartment","of","the","endoplasmic","reticulum","in","which","proteins","with","improper","or","incorrect","folding","accumulate",".","Enzymes","in","this","compartment","direct","proteins","with","major","folding","problems","to","translocation","to","the","cytosol","and","degradation",",","and","proteins","with","minor","folding","problems","to","the","ER",",","to","interact","with","chaperon","proteins","."),4287819). assertion_content_comment('tOboGo_EndoplasmicReticulumReceptorActivity',s("OBSOLETE",".","A","receptor","in","the","endoplasmic","reticulum","."),4215138). assertion_content_comment('tOboGo_EndoplasmicReticulumSecComplex',s("An","endoplasmic","reticulum","membrane-associated","complex","involved","in","the","translocation","of","proteins","that","are","targeted","to","the","ER",".","In","yeast",",","this","complex","consists","of","two","subcomplexes",",","namely",",","the","Sec61","complex","and","the","Sec62/Sec63","complex","."),4062477). assertion_content_comment('tOboGo_EndoplasmicReticulumSignalPeptideBinding',s("Interacting","selectively","and","non-covalently","with","an","endoplasmic","reticulum","signal","peptide",",","a","specific","peptide","sequence","that","acts","as","a","signal","to","localize","the","protein","within","the","endoplasmic","reticulum","."),4307501). assertion_content_comment('tOboGo_EndoplasmicReticulumTubularNetworkAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","endoplasmic","reticulum","(","ER",")","tubular","network",".","The","ER","tubular","network","is","the","ER","part","that","comprises","the","membranes","with","high","curvature","in","cross-section","."),4169152). assertion_content_comment('tOboGo_EndoplasmicReticulumTubularNetworkMaintenance',s("The","organization","process","that","preserves","the","endoplasmic","reticulum","(","ER",")","tubular","network","in","a","stable","functional","or","structural","state",".","The","ER","tubular","network","is","the","ER","part","that","comprises","the","membranes","with","high","curvature","in","cross-section","."),4169141). assertion_content_comment('tOboGo_EndoplasmicReticulumTubularNetworkOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","endoplasmic","reticulum","(","ER",")","tubular","network",".","The","ER","tubular","network","is","the","ER","part","that","comprises","the","membranes","with","high","curvature","in","cross-section","."),4169135). assertion_content_comment('tOboGo_EndoplasmicReticulumTubularNetwork',s("An","endoplasmic","reticulum","part","that","comprises","the","membranes","with","high","curvature","in","cross-section","."),4169200). assertion_content_comment('tOboGo_EndoplasmicReticulumUnfoldedProteinResponse',s("The","series","of","molecular","signals","generated","as","a","consequence","of","the","presence","of","unfolded","proteins","in","the","endoplasmic","reticulum","(","ER",")","or","other","ER-related","stress",";","results","in","changes","in","the","regulation","of","transcription","and","translation","."),4013527). assertion_content_comment('tOboGo_EndopolyphosphataseActivity',s("Catalysis","of","the","reaction",":","polyphosphate","+","n","H2O","=","(","n","+","1",")","oligophosphate",".","The","product","contains","4","or","5","phosphate","residues","."),4346732). assertion_content_comment('tOboGo_EndoribonucleaseActivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","ribonucleic","acid","by","creating","internal","breaks","."),4174709). 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assertion_content_comment('tOboGo_EndosomeMembrane',s("The","lipid","bilayer","surrounding","an","endosome","."),3978125). assertion_content_comment('tOboGo_EndosomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","endosomes","."),4102237). assertion_content_comment('tOboGo_Endosome',s("A","membrane-bounded","organelle","to","which","materials","ingested","by","endocytosis","are","delivered","."),3978120). assertion_content_comment('tOboGo_EndosomeToLysosomeTransport',s("The","directed","movement","of","substances","from","endosomes","to","lysosomes","."),4154752). assertion_content_comment('tOboGo_EndosomeToLysosomeTransportViaMultivesicularBodySortingPathway',s("The","directed","movement","of","substances","from","endosomes","to","lysosomes","by","a","pathway","in","which","molecules","are","sorted","into","multivesicular","bodies",",","which","then","fuse","with","the","lysosome","."),4335407). assertion_content_comment('tOboGo_EndosomeToMelanosomeTransport',s("The","directed","movement","of","substances","from","endosomes","to","the","melanosome",",","a","specialised","lysosome-related","organelle","."),4379983). assertion_content_comment('tOboGo_EndosomeToPigmentGranuleTransport',s("The","directed","movement","of","substances","from","endosomes","to","pigment","granules","."),4096146). assertion_content_comment('tOboGo_EndosomeToPlasmaMembraneTransportVesicle',s("A","transport","vesicle","that","mediates","transport","from","the","endosome","to","the","plasma","membrane",",","and","fuses","with","the","plasma","membrane","to","release","various","cargo","molecules",",","such","as","proteins","or","hormones",",","by","exocytosis","."),4173588). assertion_content_comment('tOboGo_EndosomeTransport',s("The","directed","movement","of","substances","into",",","out","of","or","mediated","by","an","endosome",",","a","membrane-bounded","organelle","that","carries","materials","newly","ingested","by","endocytosis",".","It","passes","many","of","the","materials","to","lysosomes","for","degradation","."),4025296). 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assertion_content_comment('tOboGo_EndosporeCortex',s("A","layer","surrounding","a","bacterial","endospore","found","inside","the","outer","endospore","membrane",",","but","outside","the","membrane","surrounding","the","endospore","core",".","It","consists","of","peptidoglycan","of","a","different","chemical","nature","than","that","found","in","vegetative","cell","walls","which","results","in","less","cross-linking","of","peptidoglycan","."),4094773). assertion_content_comment('tOboGo_EndosporeExternalEncapsulatingStructure',s("The","structures","that","lie","outside","the","inner","membrane","and","surround","the","entire","endospore",";","consists","of","a","peptidoglycan-containing","inner","layer","(","the","endospore","cortex",")","surrounded","by","a","multilayered","proteinaceous","coat",".","An","exosporium","may","be","present","as","an","extreme","outer","layer","."),4094722). assertion_content_comment('tOboGo_EndosporeFormation',s("The","process","in","which","a","cell","gives","rise","to","an","endospore",",","a","dormant",",","highly","resistant","spore","with","a","thick","wall","that","forms","within","the","mother","cell",".","Endospores","are","produced","by","some","low","G","+","C","Gram-positive","bacteria","in","response","to","harsh","conditions","."),4354901). assertion_content_comment('tOboGo_EndosulfanDiolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","endosulfan","diol","=","endosulfan","hydroxyether","+","2","H","+","+","2","e-","."),4351160). assertion_content_comment('tOboGo_EndosulfanDiolHydrolyaseCyclizingActivity',s("Catalysis","of","the","reaction",":","endosulfan","diol","=","endosulfan","ether","+","H2O","."),4351151). assertion_content_comment('tOboGo_EndosulfanEtherMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","endosulfan","ether","+","O2","+","2","H","+","+","2","e-","=","endosulfan","hydroxyether","+","H2O","."),4350205). assertion_content_comment('tOboGo_EndosulfanHemisulfateSulfataseActivity',s("Catalysis","of","the","reaction",":","endosulfan","hemisulfate","+","H2O","=","endosulfan","monoalcohol","+","2","H","+","+","sulfate","."),4351133). assertion_content_comment('tOboGo_EndosulfanHydroxyetherDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","endosulfan","hydroxyether","=","endosulfan","lactone","+","2","H","+","+","2","e-","."),4350160). assertion_content_comment('tOboGo_EndosulfanLactoneLactonaseActivity',s("Catalysis","of","the","reaction",":","endosulfan","lactone","+","H2O","=","endosulfan","hydroxycarboxylate","+","H","+"),4351169). assertion_content_comment('tOboGo_EndosulfanMonooxygenaseIActivity',s("Catalysis","of","the","reaction",":","endosulfan","+","O2","+","2","H","+","+","2","e-","=","endosulfan","sulfate","+","H2O","."),4351142). assertion_content_comment('tOboGo_EndosulfanSulfateHydrolaseActivity',s("Catalysis","of","the","reaction",":","endosulfan","sulfate","+","H2O","=","endosulfan","diol","+","sulfite","."),4350151). assertion_content_comment('tOboGo_EndothelialCellActivationInvolvedInImmuneResponse',s("A","change","in","the","morphology","or","behavior","of","an","endothelial","cell","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4377771). assertion_content_comment('tOboGo_EndothelialCellActivation',s("The","change","in","morphology","and","behavior","of","an","endothelial","cell","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),4313885). assertion_content_comment('tOboGo_EndothelialCellActivationWithinHighEndothelialVenuleInvolvedInImmuneResponse',s("A","change","in","the","morphology","or","behavior","of","an","endothelial","cell","within","a","high","endothelial","venule","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4377774). assertion_content_comment('tOboGo_EndothelialCellApoptosis',s("The","process","of","apoptosis","in","endothelial","cells",".","An","endothelial","cell","comprises","the","outermost","layer","or","lining","of","anatomical","structures","and","can","be","squamous","or","cuboidal","."),4143446). assertion_content_comment('tOboGo_EndothelialCellChemotaxis',s("The","directed","movement","of","an","endothelial","cell","guided","by","a","specific","chemical","concentration","gradient",".","Movement","may","be","towards","a","higher","concentration","(","positive","chemotaxis",")","or","towards","a","lower","concentration","(","negative","chemotaxis",")"),4145263). assertion_content_comment('tOboGo_EndothelialCellChemotaxisToFibroblastGrowthFactor',s("The","directed","movement","of","an","endothelial","cell","in","response","to","the","presence","of","fibroblast","growth","factor","(","FGF",")"),4145265). assertion_content_comment('tOboGo_EndothelialCellDevelopment',s("The","progression","of","an","endothelial","cell","over","time",",","from","its","formation","to","the","mature","structure","."),3986594). assertion_content_comment('tOboGo_EndothelialCellDifferentiation',s("The","process","in","which","a","mesodermal","angioblast","acquires","specialized","features","of","an","endothelial","cell",",","a","thin","flattened","cell",".","A","layer","of","such","cells","lines","the","inside","surfaces","of","body","cavities",",","blood","vessels",",","and","lymph","vessels",",","making","up","the","endothelium","."),3986574). assertion_content_comment('tOboGo_EndothelialCellFateCommitment',s("The","commitment","of","a","cell","to","an","endothelial","cell","fate","and","its","capacity","to","differentiate","into","an","endothelial","cell","."),4112819). assertion_content_comment('tOboGo_EndothelialCellFateDetermination',s("A","process","involved","in","cell","fate","commitment","of","an","endothelial","cell",".","Once","determination","has","taken","place",",","a","cell","becomes","committed","to","differentiate","down","a","particular","pathway","regardless","of","its","environment","."),4113774). assertion_content_comment('tOboGo_EndothelialCellFateSpecification',s("The","process","involved","in","the","specification","of","identity","of","an","endothelial","cell",".","Once","specification","has","taken","place",",","a","cell","will","be","committed","to","differentiate","down","a","specific","pathway","if","left","in","its","normal","environment","."),4113764). assertion_content_comment('tOboGo_EndothelialCellMigration',s("The","orderly","movement","of","an","endothelial","cell","into","the","extracellular","matrix","to","form","an","endothelium","."),3990783). assertion_content_comment('tOboGo_EndothelialCellMorphogenesis',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","during","the","differentiation","of","an","endothelial","cell","."),3986614). assertion_content_comment('tOboGo_EndothelialCellProliferation',s("The","multiplication","or","reproduction","of","endothelial","cells",",","resulting","in","the","expansion","of","a","cell","population",".","Endothelial","cells","are","thin","flattened","cells","which","line","the","inside","surfaces","of","body","cavities",",","blood","vessels",",","and","lymph","vessels",",","making","up","the","endothelium","."),3988519). assertion_content_comment('tOboGo_EndothelialMicroparticleFormation',s("The","cellular","component","organization","process","in","which","microparticles","bud","off","from","an","endothelial","cell","."),4143184). 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assertion_content_comment('tOboGo_EndothelinMaturation',s("The","process","leading","to","the","attainment","of","the","full","functional","capacity","of","endothelin","by","conversion","of","Big-endothelin","substrate","into","mature","endothelin","."),4073157). assertion_content_comment('tOboGo_EndothelinReceptorActivity',s("Combining","with","endothelin","to","initiate","a","change","in","cell","activity","."),4198132). assertion_content_comment('tOboGo_EndotheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","endothelium","over","time",",","from","its","formation","to","the","mature","structure",".","An","endothelium","is","an","epithelium","that","lines","an","anatomical","structure","."),3986572). assertion_content_comment('tOboGo_EndotoxinActivity',s("OBSOLETE",".","The","function","of","any","microbial","toxin","that","cannot","be","easily","separated","from","the","structure","of","the","cell","."),4233689). 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assertion_content_comment('tOboGo_EnteropeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","selective","cleavage","of","Lys6-Ile7","bond","in","trypsinogen","."),4209409). assertion_content_comment('tOboGo_EnterotoxinActivity',s("OBSOLETE",".","Acts","as","to","cause","injury","to","the","intestinal","mucosa","of","other","living","organisms","."),4233714). assertion_content_comment('tOboGo_EntrainmentOfCircadianClockByPhotoperiod',s("The","synchronization","of","a","circadian","rhythm","to","photoperiod",",","the","intermittent","cycle","of","light","(","day",")","and","dark","(","night",")"),4317584). assertion_content_comment('tOboGo_EntrainmentOfCircadianClock',s("The","synchronization","of","a","circadian","rhythm","to","environmental","time","cues","such","as","light","."),4261240). assertion_content_comment('tOboGo_EntryIntoCellOfOtherOrganismInvolvedInSymbioticInteraction',s("The","invasion","by","an","organism","of","a","cell","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4045558). assertion_content_comment('tOboGo_EntryIntoDiapause',s("The","dormancy","process","that","results","in","entry","into","diapause",".","Diapause","is","a","neurohormonally","mediated",",","dynamic","state","of","low","metabolic","activity",".","Associated","characteristics","of","this","form","of","dormancy","include","reduced","morphogenesis",",","increased","resistance","to","environmental","extremes",",","and","altered","or","reduced","behavioral","activity",".","Full","expression","develops","in","a","species-specific","manner",",","usually","in","response","to","a","number","of","environmental","stimuli","that","precede","unfavorable","conditions",".","Once","diapause","has","begun",",","metabolic","activity","is","suppressed","even","if","conditions","favorable","for","development","prevail",".","Once","initiated",",","only","certain","stimuli","are","capable","of","releasing","the","organism","from","this","state",",","and","this","characteristic","is","essential","in","distinguishing","diapause","from","hibernation","."),4094257). 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assertion_content_comment('tOboGo_EntryIntoHostViaEnzymaticDegradationOfHostCuticle',s("Penetration","by","symbiont","of","host","physical","barriers",",","mediated","by","symbiont","degradative","enzymes","."),4083690). assertion_content_comment('tOboGo_EntryIntoOtherOrganismInvolvedInSymbioticInteraction',s("Penetration","by","an","organism","into","the","body",",","tissues",",","or","cells","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4045523). assertion_content_comment('tOboGo_EntryIntoOtherOrganismThroughBarriersOfOtherOrganismInvolvedInSymbioticInteraction',s("Penetration","by","an","organism","into","a","second","organism","via","active","breaching","of","physical","barriers",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4083659). assertion_content_comment('tOboGo_EntryIntoOtherOrganismThroughNaturalPortalsInvolvedInSymbioticInteraction',s("Penetration","by","an","organism","into","a","second","organism","via","naturally","occurring","openings","in","the","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4282652). assertion_content_comment('tOboGo_EntryIntoReproductiveDiapause',s("The","dormancy","process","that","results","in","entry","into","reproductive","diapause",".","Reproductive","diapause","is","a","form","of","diapause","where","the","organism","itself","will","remain","fully","active",",","including","feeding","and","other","routine","activities",",","but","the","reproductive","organs","experience","a","tissue-specific","reduction","in","metabolism",",","with","characteristic","triggering","and","releasing","stimuli","."),4222312). assertion_content_comment('tOboGo_EntryOfBacteriumIntoHostCell',s("The","process","in","which","a","bacterium","enters","a","host","cell",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4145099). assertion_content_comment('tOboGo_EntryOfOrganismIntoCellOfOtherOrganismByPromotionOfPhagocytosisInOtherOrganismInvolvedInSymbioticInteraction',s("The","invasion","by","an","organism","of","a","cell","of","a","second","organism","by","utilizing","the","second","organism","'","s","phagocytosis","mechanism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190330). assertion_content_comment('tOboGo_EntryOfSymbiontIntoHostCellByPromotionOfHostPhagocytosis',s("The","invasion","by","an","organism","of","a","cell","of","its","host","organism","by","utilizing","the","host","phagocytosis","mechanism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195651). assertion_content_comment('tOboGo_EntryOfVirusIntoHostCell',s("The","process","in","which","a","virion","enters","a","host","cell",",","including","virion","attachment","and","penetration","."),4045566). assertion_content_comment('tOboGo_EnucleateErythrocyteDevelopment',s("The","process","aimed","at","the","progression","of","an","enucleate","erythrocyte","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4092812). assertion_content_comment('tOboGo_EnucleateErythrocyteDifferentiation',s("The","process","in","which","a","myeloid","precursor","cell","acquires","specialized","features","of","an","erythrocyte","without","a","nucleus",".","An","example","of","this","process","is","found","in","Mus","musculus","."),4092808). assertion_content_comment('tOboGo_EnucleateErythrocyteMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","an","enucleate","erythrocyte","to","attain","its","fully","functional","state",".","An","enucleate","erythrocyte","is","an","erythrocyte","without","a","nucleus","."),4092816). assertion_content_comment('tOboGo_Enucleation',s("The","process","in","which","nucleated","precursor","cells","lose","their","nucleus","during","erythrocyte","maturation","."),4092828). assertion_content_comment('tOboGo_Envelope',s("A","multilayered","structure","surrounding","all","or","part","of","a","cell",";","encompasses","one","or","more","lipid","bilayers",",","and","may","include","a","cell","wall","layer",";","also","includes","the","space","between","layers","."),3974079). assertion_content_comment('tOboGo_Envenomation',s("The","process","by","which","venom","is","forced","into","an","organism","by","the","bite","or","sting","of","another","organism","."),4380757). assertion_content_comment('tOboGo_EnzymeActivatorActivity',s("Increases","the","activity","of","an","enzyme","."),4156042). assertion_content_comment('tOboGo_EnzymeActiveSiteFormation',s("The","modification","of","part","of","an","enzyme","to","form","the","active","site","."),4272964). assertion_content_comment('tOboGo_EnzymeBinding',s("Interacting","selectively","and","non-covalently","with","any","enzyme","."),4073906). assertion_content_comment('tOboGo_EnzymeInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","an","enzyme","."),4155302). assertion_content_comment('tOboGo_EnzymeLinkedReceptorProteinSignalingPathway',s("Any","series","of","molecular","signals","initiated","by","the","binding","of","an","extracellular","ligand","to","a","receptor","on","the","surface","of","the","target","cell",",","where","the","receptor","possesses","catalytic","activity","or","is","closely","associated","with","an","enzyme","such","as","a","protein","kinase","."),4001263). assertion_content_comment('tOboGo_EnzymeRegulatorActivity',s("Modulates","the","activity","of","an","enzyme","."),4074093). assertion_content_comment('tOboGo_EosinophilActivationInvolvedInImmuneResponse',s("The","change","in","morphology","and","behavior","of","a","eosinophil","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4093426). assertion_content_comment('tOboGo_EosinophilActivation',s("The","change","in","morphology","and","behavior","of","a","eosinophil","resulting","from","exposure","to","a","cytokine",",","chemokine",",","cellular","ligand",",","or","soluble","factor","."),4093424). assertion_content_comment('tOboGo_EosinophilChemotaxis',s("The","movement","of","an","eosinophil","in","response","to","an","external","stimulus","."),4141800). assertion_content_comment('tOboGo_EosinophilDegranulation',s("The","regulated","exocytosis","of","secretory","granules","containing","preformed","mediators","such","as","major","basic","protein",",","eosinophil","peroxidase",",","and","eosinophil","cationic","protein","by","an","eosinophil","."),4093441). assertion_content_comment('tOboGo_EosinophilDifferentiation',s("The","process","in","which","a","relatively","unspecialized","myeloid","precursor","cell","acquires","the","specializes","features","of","an","eosinophil","."),4087573). assertion_content_comment('tOboGo_EosinophilExtravasation',s("The","migration","of","an","eosinophil","from","the","blood","vessels","into","the","surrounding","tissue","."),4141854). assertion_content_comment('tOboGo_EosinophilMediatedImmunity',s("Any","process","involved","in","the","carrying","out","of","an","immune","response","by","an","eosinophil","."),4093439). assertion_content_comment('tOboGo_EosinophilMigration',s("The","movement","of","an","eosinophil","within","or","between","different","tissues","and","organs","of","the","body","."),4141798). assertion_content_comment('tOboGo_EP1SubtypeProstaglandinE2ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","EP1","subtype","prostaglandin","E2","receptor","."),4323837). assertion_content_comment('tOboGo_EP2SubtypeProstaglandinE2ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","EP2","subtype","prostaglandin","E2","receptor","."),4323870). assertion_content_comment('tOboGo_EP3SubtypeProstaglandinE2ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","EP3","subtype","prostaglandin","E2","receptor","."),4323859). assertion_content_comment('tOboGo_EP4SubtypeProstaglandinE2ReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","EP4","subtype","prostaglandin","E2","receptor","."),4323815). assertion_content_comment('tOboGo_EphedrineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","1R",",","2S",")","-ephedrine","+","NAD","(","+",")","=","(","R",")","-2-methylimino-1-phenylpropan-1-ol","+","2","H","(","+",")","+","NADH","."),4376207). assertion_content_comment('tOboGo_EphrinReceptorActivity',s("Combining","with","an","ephrin","to","initiate","a","change","in","cell","activity","."),4213768). assertion_content_comment('tOboGo_EphrinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","ephrin","receptor","."),4214305). assertion_content_comment('tOboGo_EphrinReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","ephrin","receptor","binding","to","an","ephrin","."),4384738). assertion_content_comment('tOboGo_Ephrin',s("OBSOLETE",".","A","class","of","proteins","that","interact","with","the","ephrin","receptors","."),4214312). assertion_content_comment('tOboGo_EpibolyInvolvedInGastrulationWithMouthFormingSecond',s("The","expansion","of","one","cell","sheet","over","other","cells","involved","in","deuterostomic","gastrulation","."),4109532). assertion_content_comment('tOboGo_EpicardialCellToMesenchymalCellTransition',s("A","transition","where","an","epicardial","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell",".","The","epicardium","is","a","part","of","the","pericardium","."),4194086). assertion_content_comment('tOboGo_EpidermalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","epidermal","cell",",","any","of","the","cells","making","up","the","epidermis","."),3982388). assertion_content_comment('tOboGo_EpidermalCellDivision',s("Any","process","resulting","in","the","physical","partitioning","and","separation","of","an","epidermal","cell",",","any","of","the","cells","making","up","the","epidermis",",","into","daughter","cells","."),4029617). assertion_content_comment('tOboGo_EpidermalCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","epidermal","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4032598). assertion_content_comment('tOboGo_EpidermalGrowthFactorBinding',s("Interacting","selectively","and","non-covalently","with","epidermal","growth","factor","."),4334643). assertion_content_comment('tOboGo_EpidermalGrowthFactorLigandProcessing',s("The","proteolysis","of","epidermal","growth","factor","after","its","internalization","via","binding","to","its","receptor","."),4017196). assertion_content_comment('tOboGo_EpidermalGrowthFactorReceptorActivatingLigandActivity',s("OBSOLETE",".","This","term","was","not","defined","before","being","made","obsolete","."),4217344). assertion_content_comment('tOboGo_EpidermalGrowthFactorReceptorActivity',s("Combining","with","an","epidermal","growth","factor","to","initiate","a","change","in","cell","activity","."),4213841). assertion_content_comment('tOboGo_EpidermalGrowthFactorReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","epidermal","growth","factor","receptor","."),4217255). 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assertion_content_comment('tOboGo_EpidermalGrowthFactorSignalingPathwayInvolvedInForebrainNeuronFateCommitment',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","epidermal","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","that","contributes","to","the","commitment","of","a","neuroblast","to","a","neuronal","fate",".","The","neuron","will","reside","in","the","forebrain","."),4053428). 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assertion_content_comment('tOboGo_EpithelialCellFateDeterminationOpenTrachealSystem',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","epithelial","cell","within","an","open","tracheal","system","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed",".","Tracheal","cells","are","set","aside","as","10","clusters","of","approximately","80","cells","on","each","side","of","the","embryo","(","termed","tracheal","placodes",")","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4017398). 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assertion_content_comment('tOboGo_EpithelialCellMigrationInvolvedInMesonephricNephronTubuleMorphogenesis',s("The","orderly","movement","of","epithelial","cells","within","a","renal","tubule","that","contributes","to","mesonephric","nephron","tubule","morphogenesis","."),4134451). assertion_content_comment('tOboGo_EpithelialCellMigrationInvolvedInMesonephricProximalTubuleMorphogenesis',s("The","orderly","movement","of","epithelial","cells","within","a","renal","tubule","that","contributes","to","mesonephric","proximal","tubule","morphogenesis","."),4134620). assertion_content_comment('tOboGo_EpithelialCellMigrationInvolvedInMetanephricDistalTubuleMorphogenesis',s("The","orderly","movement","of","epithelial","cells","within","a","renal","tubule","that","contributes","to","metanephric","distal","tubule","morphogenesis","."),4124703). assertion_content_comment('tOboGo_EpithelialCellMigrationInvolvedInMetanephricNephronTubuleMorphogenesis',s("The","orderly","movement","of","epithelial","cells","within","a","renal","tubule","that","contributes","to","metanephric","nephron","tubule","morphogenesis","."),4124408). assertion_content_comment('tOboGo_EpithelialCellMigrationInvolvedInMetanephricProximalTubuleMorphogenesis',s("The","orderly","movement","of","epithelial","cells","within","a","renal","tubule","that","contributes","to","metanephric","proximal","tubule","morphogenesis","."),4124692). assertion_content_comment('tOboGo_EpithelialCellMigrationInvolvedInNephronTubuleMorphogenesis',s("The","orderly","movement","of","epithelial","cells","within","a","renal","tubule","that","contributes","to","nephron","tubule","morphogenesis","."),4123198). assertion_content_comment('tOboGo_EpithelialCellMigrationInvolvedInProximalTubuleMorphogenesis',s("The","orderly","movement","of","epithelial","cells","within","a","renal","tubule","that","contributes","to","proximal","tubule","morphogenesis","."),4123218). assertion_content_comment('tOboGo_EpithelialCellMigrationOpenTrachealSystem',s("The","orderly","movement","of","epithelial","cells","during","development","of","an","open","tracheal","system",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4017421). assertion_content_comment('tOboGo_EpithelialCellMigration',s("The","orderly","movement","of","epithelial","cells","from","one","site","to","another",",","often","during","the","development","of","a","multicellular","organism","."),4005608). assertion_content_comment('tOboGo_EpithelialCellMorphogenesisInvolvedInGastrulation',s("The","change","in","form","that","occurs","when","an","epithelial","cell","progresses","from","it","initial","formation","to","its","mature","state",",","contributing","to","the","process","of","gastrulation","."),4005411). assertion_content_comment('tOboGo_EpithelialCellMorphogenesisInvolvedInPlacentalBranching',s("The","change","in","form","(","cell","shape","and","size",")","that","occurs","when","a","trophoblast","cell","elongates","to","contribute","to","the","branching","of","the","placenta","."),4112475). assertion_content_comment('tOboGo_EpithelialCellMorphogenesis',s("The","change","in","form","that","occurs","when","an","epithelial","cell","progresses","from","its","initial","formation","to","its","mature","state","."),3986611). 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assertion_content_comment('tOboGo_EpithelialCellProliferationInvolvedInMammaryGlandBudElongation',s("The","multiplication","or","reproduction","of","mammary","gland","bud","epithelial","cells",",","resulting","in","the","elongation","of","the","bud","."),4111993). assertion_content_comment('tOboGo_EpithelialCellProliferationInvolvedInMammaryGlandDuctElongation',s("The","multiplication","or","reproduction","of","mammary","gland","branch","epithelial","cells",",","resulting","in","the","elongation","of","the","branch",".","The","mammary","gland","branch","differs","from","the","bud","in","that","it","is","not","the","initial","curved","portion","of","the","outgrowth","."),4110527). 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assertion_content_comment('tOboGo_EpithelialCellTypeSpecificationOpenTrachealSystem',s("Allocation","of","epithelial","cells","within","each","migrating","branch","in","an","open","tracheal","system","to","distinct","tracheal","cell","fates",".","During","the","migration","phase","each","branch","forms","a","well-defined","number","of","cell","types","(","including","fusion","cells",",","terminal","cells","and","branch","cells",")","at","precise","positions","."),4071775). assertion_content_comment('tOboGo_EpithelialCiliumMovement',s("The","directed",",","self-propelled","movement","of","a","cilium","of","an","epithelial","cell",".","This","movement","is","usually","coordinated","between","many","epithelial","cells",",","and","serves","to","move","fluid","."),4005916). assertion_content_comment('tOboGo_EpithelialFluidTransport',s("The","directed","movement","of","fluid","across","epithelia","."),4072394). assertion_content_comment('tOboGo_EpithelialStructureMaintenance',s("A","tissue","homeostatic","process","required","for","the","maintenance","of","epithelial","structure","."),4110777). assertion_content_comment('tOboGo_EpithelialToMesenchymalTransitionInvolvedInCardiacFibroblastDevelopment',s("A","transition","where","an","epicardial","cell","loses","apical/basolateral","polarity",",","severs","intercellular","adhesive","junctions",",","degrades","basement","membrane","components","and","becomes","a","migratory","mesenchymal","cell","that","will","mature","into","a","cardiac","fibroblast","."),4114510). 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assertion_content_comment('tOboGo_ERProteasomeRegulatoryParticleLidSubcomplex',s("The","subunits","that","form","the","peripheral","lid","of","the","regulatory","particle","of","a","proteasome","located","in","the","endoplasmic","reticulum","of","a","cell","."),4060141). assertion_content_comment('tOboGo_ERProteasomeRegulatoryParticle',s("The","regulatory","subcomplex","of","a","proteasome","located","in","the","endoplasmic","reticulum","of","a","cell","."),4060130). assertion_content_comment('tOboGo_ERRetentionSequenceBinding',s("Interacting","selectively","and","non-covalently","with","an","endoplasmic","reticulum","(","ER",")","retention","sequence",",","a","specific","peptide","sequence","that","ensures","a","protein","is","retained","within","the","ER","."),4215154). assertion_content_comment('tOboGo_ERToGolgiCeramideTransport',s("The","directed","movement","of","a","ceramide","from","the","endoplasmic","reticulum","(","ER",")","to","the","Golgi",".","Ceramides","are","a","class","of","lipid","composed","of","sphingosine","linked","to","a","fatty","acid","."),4379801). assertion_content_comment('tOboGo_ERToGolgiTransportVesicleMembrane',s("The","lipid","bilayer","surrounding","a","vesicle","transporting","substances","from","the","endoplasmic","reticulum","to","the","Golgi","."),4036111). assertion_content_comment('tOboGo_ERToGolgiTransportVesicle',s("A","vesicle","that","mediates","transport","from","the","endoplasmic","reticulum","to","the","Golgi","complex",";","bears","a","coat","formed","of","the","COPII","coat","complex","proteins",";","such","vesicles","found","associated","with","endoplasmic","reticulum","(","ER",")","membranes","at","steady","state",",","and","are","involved","in","ER","to","Golgi","(","anterograde",")","vesicle","transport","."),4036094). assertion_content_comment('tOboGo_ERUbiquitinLigaseComplex',s("A","ubiquitin","ligase","complex","found","in","the","ER","."),3978901). assertion_content_comment('tOboGo_ErythritolKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","erythritol","=","D-erythritol","4-phosphate","+","ADP","+","2","H","(","+",")"),4376196). assertion_content_comment('tOboGo_ErythrocyteAggregation',s("The","adhesion","of","one","erythrocyte","to","one","or","more","other","erythrocytes","via","adhesion","molecules","."),4076800). assertion_content_comment('tOboGo_ErythrocyteClearance',s("The","selective","elimination","of","erythrocytes","from","the","body","by","autoregulatory","mechanisms","."),4076564). assertion_content_comment('tOboGo_ErythrocyteDevelopment',s("The","process","aimed","at","the","progression","of","an","erythrocyte","over","time",",","from","initial","commitment","of","the","cell","to","a","specific","fate",",","to","the","fully","functional","differentiated","cell","."),4092784). assertion_content_comment('tOboGo_ErythrocyteDifferentiation',s("The","process","in","which","a","myeloid","precursor","cell","acquires","specializes","features","of","an","erythrocyte","."),4024346). assertion_content_comment('tOboGo_ErythrocyteHomeostasis',s("Any","process","of","regulating","the","production","and","elimination","of","erythrocytes","within","an","organism","."),4024342). assertion_content_comment('tOboGo_ErythrocyteMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","an","erythrocyte","to","attain","its","fully","functional","state","."),4092788). assertion_content_comment('tOboGo_ErythronolideSynthaseActivity',s("Catalysis","of","the","reaction",":","6","malonyl-CoA","+","propionyl-CoA","=","7","CoA","+","6-deoxyerythronolide","B","."),4376256). assertion_content_comment('tOboGo_ErythrophoreDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","erythrophore","cell",".","Erythrophores","are","pigment","cells","derived","from","the","neural","crest",".","They","contain","pteridine","and/or","carotenoid","pigments","in","structures","called","pterinosomes","or","erythrosomes",".","This","gives","them","an","orange","to","red","appearance","."),4105032). assertion_content_comment('tOboGo_ErythropoietinReceptorActivity',s("Combining","with","erythropoietin","to","initiate","a","change","in","cell","activity","."),4198403). assertion_content_comment('tOboGo_ErythropoietinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","erythropoietin","receptor","."),4214628). assertion_content_comment('tOboGo_ErythruloseReductaseActivity',s("Catalysis","of","the","reaction",":","D-threitol","+","NADP","(","+",")","=","D-erythrulose","+","H","(","+",")","+","NADPH","."),4376388). assertion_content_comment('tOboGo_ESCEZComplex',s("A","multimeric","protein","complex","that","can","methylate","lysine-27","and","lysine-9","residues","of","histone","H3",".","In","Drosophila","the","core","subunits","of","the","complex","include","ESC",",","E","(","Z",")",",","CAF1","(","NURF-55",")","and","SU","(","Z",")","12",".","In","mammals","the","core","subunits","of","the","complex","include","EED",",","EZH2",",","SUZ12","and","RBBP4","."),4381712). assertion_content_comment('tOboGo_ESCRTIComplex',s("An","endosomal","sorting","complex","required","for","transport",".","It","consists","of","the","class","E","vacuolar","protein","sorting","(","Vps",")","proteins","and","interacts","with","ubiquitinated","cargoes","."),3978272). assertion_content_comment('tOboGo_ESCRTIIComplex',s("An","endosomal","sorting","complex","required","for","transport","and","functions","downstream","of","ESCRT","I","complex",".","It","consists","of","the","class","E","vacuolar","protein","sorting","(","Vps",")","proteins","and","is","required","for","the","membrane","recruitment","of","ESCRT","III","complex","and","binds","to","ubiquitinated","cargoes","."),3978137). assertion_content_comment('tOboGo_ESCRTIIIComplex',s("An","endosomal","sorting","complex","required","for","transport",".","Consists","of","two","soluble","subcomplexes","of","highly","charged","coiled-coil","proteins","and","is","required","for","sorting","and/or","concentration","of","multivesicular","body","(","MVB",")","cargoes","."),3978150). assertion_content_comment('tOboGo_EsculetinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","esculetin",",","6",",","7-dihydroxycoumarin","."),4339700). assertion_content_comment('tOboGo_EsculetinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","esculetin",",","6",",","7-dihydroxycoumarin","."),4339697). assertion_content_comment('tOboGo_EsophagusSmoothMuscleContraction',s("A","process","in","which","force","is","generated","within","smooth","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","This","process","occurs","in","the","esophagus",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","esophagus","is","the","muscular","membranous","segment","between","the","pharynx","and","the","stomach","in","the","upper","gastrointestinal","tract","."),4321247). assertion_content_comment('tOboGo_EstablishmentOfAnatomicalStructureOrientation',s("The","process","that","determines","the","orientation","of","an","anatomical","structure","with","reference","to","an","axis","."),4102960). assertion_content_comment('tOboGo_EstablishmentOfApicalBasalCellPolarity',s("The","specification","and","formation","of","the","polarity","of","a","cell","along","its","apical/basal","axis","."),4002122). assertion_content_comment('tOboGo_EstablishmentOfBCellPolarity',s("The","directed","orientation","of","B","cell","signaling","molecules","and","associated","membrane","rafts","towards","a","chemokine","gradient","of","a","contact","point","with","an","antigen","displaying","cell","."),3984652). assertion_content_comment('tOboGo_EstablishmentOfBipolarCellPolarityInvolvedInCellMorphogenesis',s("The","specification","and","formation","of","bipolar","intracellular","organization","or","cell","growth","patterns","that","contribute","to","cell","morphogenesis",".","Bipolar","organization","is","the","organization","that","is","a","mirror","image","along","an","axis","from","a","plane","."),4135863). assertion_content_comment('tOboGo_EstablishmentOfBipolarCellPolarity',s("The","specification","and","formation","of","bipolar","intracellular","organization","or","cell","growth","patterns",".","Bipolar","organization","is","the","organization","that","is","a","mirror","image","along","an","axis","from","a","plane","."),4135860). assertion_content_comment('tOboGo_EstablishmentOfBodyBristlePlanarOrientation',s("Orientation","along","the","body","surface","of","bristles",",","sensory","organs","originating","from","a","sensory","organ","precursor","cell",",","such","that","they","all","point","in","a","uniform","direction","."),4104275). assertion_content_comment('tOboGo_EstablishmentOfBodyHairOrBristlePlanarOrientation',s("Orientation","of","hairs","or","sensory","bristles","that","cover","the","body","surface","of","an","adult",",","such","that","they","all","point","in","a","uniform","direction","along","the","plane","of","the","epithelium","from","which","they","project","."),4104272). assertion_content_comment('tOboGo_EstablishmentOfBodyHairPlanarOrientation',s("Orientation","of","body","hairs",",","projections","from","the","surface","of","an","organism",",","such","that","the","hairs","all","point","in","a","uniform","direction","along","the","surface","."),4385317). assertion_content_comment('tOboGo_EstablishmentOfCellPolarityInvolvedInAmeboidalCellMigration',s("The","specification","and","formation","of","anisotropic","intracellular","organization","that","contributes","to","the","self-propelled","directed","movement","of","an","ameboid","cell","."),4005467). assertion_content_comment('tOboGo_EstablishmentOfCellPolarityInvolvedInGastrulationCellMigration',s("The","specification","and","formation","of","anisotropic","intracellular","organization","that","contributes","to","the","self-propelled","directed","movement","of","an","ameboid","cell","taking","part","in","gastrulation","."),4005480). assertion_content_comment('tOboGo_EstablishmentOfCellPolarityInvolvedInGrowthPlateCartilageChondrocyteDivision',s("The","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","anisotropic","intracellular","organization","that","results","in","the","directional","division","of","a","growth","plate","cartilage","chondrocyte","."),4004381). assertion_content_comment('tOboGo_EstablishmentOfCellPolarityInvolvedInMesendodermalCellMigration',s("The","specification","and","formation","of","anisotropic","intracellular","organization","that","contributes","to","the","self-propelled","directed","movement","of","a","mesendodermal","cell","."),4005636). assertion_content_comment('tOboGo_EstablishmentOfCellPolarity',s("The","specification","and","formation","of","anisotropic","intracellular","organization","or","cell","growth","patterns","."),3974020). assertion_content_comment('tOboGo_EstablishmentOfCentralGapGeneBoundaries',s("Specification","of","the","borders","of","central","gap","gene","expression","mediated","largely","by","the","effects","of","other","gap","genes",";","in","insects","this","is","exemplified","by","knirps","repression","of","Kruppel","."),4019269). assertion_content_comment('tOboGo_EstablishmentOfCentrosomeLocalization',s("The","directed","movement","of","the","centrosome","to","a","specific","location","."),4121771). assertion_content_comment('tOboGo_EstablishmentOfChromatinSilencingAtTelomere',s("The","initial","formation","of","a","transcriptionally","silent","chromatin","structure","such","as","heterochromatin","at","the","telomere","."),4083187). assertion_content_comment('tOboGo_EstablishmentOfChromatinSilencing',s("The","initial","formation","of","a","transcriptionally","silent","chromatin","structure","such","as","heterochromatin","."),4009319). assertion_content_comment('tOboGo_EstablishmentOfChromosomeLocalization',s("The","directed","movement","of","a","chromosome","to","a","specific","location","."),4012604). assertion_content_comment('tOboGo_EstablishmentOfCompetenceForTransformation',s("The","process","in","which","a","naturally","transformable","bacterium","acquires","the","ability","to","take","up","exogenous","DNA",".","This","term","should","be","applied","only","to","naturally","transformable","bacteria",",","and","should","not","be","used","in","the","context","of","artificially","induced","bacterial","transformation","."),4046304). assertion_content_comment('tOboGo_EstablishmentOfContractileRingLocalizationInvolvedInCellCycleCytokinesis',s("The","process","in","which","a","contractile","ring","is","assembled","in","a","specific","location","as","part","of","a","process","of","cell","cycle","cytokinesis","."),4055395). assertion_content_comment('tOboGo_EstablishmentOfDenseCoreGranuleLocalization',s("The","directed","movement","of","a","dense","core","granule","to","a","specific","location","."),4054022). assertion_content_comment('tOboGo_EstablishmentOfDosageCompensation',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4234415). assertion_content_comment('tOboGo_EstablishmentOfEndoplasmicReticulumLocalizationInvolvedInEndoplasmicReticulumPolarizationAtCellDivisionSite',s("The","directed","movement","of","the","endoplasmic","reticulum","to","the","site","where","a","cell","will","divide","."),4135750). assertion_content_comment('tOboGo_EstablishmentOfEndothelialBarrier',s("The","establishment","of","a","barrier","between","endothelial","cell","layers",",","such","as","those","in","the","brain",",","lung","or","intestine",",","to","exert","specific","and","selective","control","over","the","passage","of","water","and","solutes",",","thus","allowing","formation","and","maintenance","of","compartments","that","differ","in","fluid","and","solute","composition","."),4039573). assertion_content_comment('tOboGo_EstablishmentOfEpithelialCellApicalBasalPolarity',s("The","specification","and","formation","of","the","apicobasal","polarity","of","an","epithelial","cell","."),4002144). assertion_content_comment('tOboGo_EstablishmentOfEpithelialCellPlanarPolarity',s("The","specification","and","formation","of","the","polarity","of","an","epithelial","cell","along","the","plane","of","the","epithelial","tissue","."),4154765). assertion_content_comment('tOboGo_EstablishmentOfEpithelialCellPolarity',s("The","specification","and","formation","of","anisotropic","intracellular","organization","of","an","epithelial","cell","."),4002142). assertion_content_comment('tOboGo_EstablishmentOfERLocalization',s("The","directed","movement","of","the","endoplasmic","reticulum","to","a","specific","location","."),4121980). assertion_content_comment('tOboGo_EstablishmentOfFloralOrganOrientation',s("The","process","that","determines","the","orientation","of","the","floral","organs","with","reference","to","the","central","axis","of","the","flower","."),4103006). assertion_content_comment('tOboGo_EstablishmentOfGolgiLocalization',s("The","directed","movement","of","the","Golgi","to","a","specific","location","."),4121883). assertion_content_comment('tOboGo_EstablishmentOfGranzymeBLocalizationInTCellSecretoryGranule',s("The","directed","movement","of","the","protease","granzyme","B","to","a","location","within","a","secretory","granule","in","a","T","cell","."),4063311). assertion_content_comment('tOboGo_EstablishmentOfLocalizationInCell',s("The","directed","movement","of","a","substance","or","cellular","entity",",","such","as","a","protein","complex","or","organelle",",","to","a","specific","location","within",",","or","in","the","membrane","of",",","a","cell","."),3969998). assertion_content_comment('tOboGo_EstablishmentOfLocalization',s("The","directed","movement","of","a","cell",",","substance","or","cellular","entity",",","such","as","a","protein","complex","or","organelle",",","to","a","specific","location","."),3969978). assertion_content_comment('tOboGo_EstablishmentOfLymphocytePolarity',s("The","directed","orientation","of","lymphocyte","signaling","molecules","and","associated","membrane","rafts","towards","a","chemokine","gradient","or","a","contact","point","with","an","appropriate","activating","cell","."),3984622). assertion_content_comment('tOboGo_EstablishmentOfMeioticSisterChromatidCohesion',s("The","process","in","which","the","sister","chromatids","of","a","replicated","chromosome","become","joined","along","the","entire","length","of","the","chromosome","during","S","phase","during","a","meiotic","cell","cycle","."),4077028). assertion_content_comment('tOboGo_EstablishmentOfMeioticSpindleLocalization',s("The","cell","cycle","process","in","which","the","directed","movement","of","the","meiotic","spindle","to","a","specific","location","in","the","cell","occurs","."),4118075). assertion_content_comment('tOboGo_EstablishmentOfMeioticSpindleOrientation',s("Any","process","that","set","the","alignment","of","meiotic","spindle","relative","to","other","cellular","structures","."),4285816). assertion_content_comment('tOboGo_EstablishmentOfMelanosomeLocalization',s("The","directed","movement","of","a","melanosome","to","a","specific","location","."),4056463). assertion_content_comment('tOboGo_EstablishmentOfMitochondrionLocalizationByMicrotubuleAttachment',s("The","directed","movement","of","a","mitochondrion","by","attachment","to","a","microtubule",",","followed","by","elongation","of","the","microtubule","by","tubulin","polymerization","."),4353812). assertion_content_comment('tOboGo_EstablishmentOfMitochondrionLocalizationInvolvedInMitochondrialFission',s("The","directed","movement","of","mitochondria","to","the","correct","region","of","the","cell","that","contributes","to","the","process","of","mitochondrial","fission","."),4149176). assertion_content_comment('tOboGo_EstablishmentOfMitochondrionLocalization',s("The","directed","movement","of","the","mitochondrion","to","a","specific","location","."),4121841). assertion_content_comment('tOboGo_EstablishmentOfMitoticSisterChromatidCohesion',s("The","process","in","which","the","sister","chromatids","of","a","replicated","chromosome","become","joined","along","the","entire","length","of","the","chromosome","during","S","phase","during","a","mitotic","cell","cycle","."),4077018). assertion_content_comment('tOboGo_EstablishmentOfMitoticSpindleLocalization',s("The","cell","cycle","process","in","which","the","directed","movement","of","the","mitotic","spindle","to","a","specific","location","in","the","cell","occurs","."),4081775). assertion_content_comment('tOboGo_EstablishmentOfMitoticSpindleOrientationInvolvedInGrowthPlateCartilageChondrocyteDivision',s("A","cell","cycle","process","that","sets","the","alignment","of","mitotic","spindle","relative","to","other","cellular","structures","and","contributes","to","oriented","chondrocyte","division","in","the","growth","plate","."),4192256). assertion_content_comment('tOboGo_EstablishmentOfMitoticSpindleOrientation',s("A","cell","cycle","process","that","sets","the","alignment","of","mitotic","spindle","relative","to","other","cellular","structures","."),4192248). assertion_content_comment('tOboGo_EstablishmentOfMonopolarCellPolarity',s("The","specification","and","formation","of","monopolar","intracellular","organization","or","cell","growth","patterns",".","Monopolar","cell","organization","is","directional","organization","along","an","axis","."),4002120). assertion_content_comment('tOboGo_EstablishmentOfMyocardialProgenitorCellApicalBasalPolarity',s("The","specification","and","formation","of","the","apicobasal","polarity","of","an","myocardial","progenitor","cell","that","contributes","to","the","formation","of","the","heart","rudiment","."),4002147). assertion_content_comment('tOboGo_EstablishmentOfNaturalKillerCellPolarity',s("The","directed","orientation","of","natural","killer","cell","signaling","molecules","and","associated","membrane","rafts","towards","a","chemokine","gradient","or","a","contact","point","with","a","cell","displaying","natural","killer","cell","activating","ligands","."),3984626). assertion_content_comment('tOboGo_EstablishmentOfNeuroblastPolarity',s("The","specification","and","formation","of","the","apicobasal","polarity","of","a","neuroblast","cell",",","a","progenitor","of","the","central","nervous","system","."),4299056). assertion_content_comment('tOboGo_EstablishmentOfNucleusLocalization',s("The","directed","movement","of","the","nucleus","to","a","specific","location","within","a","cell","."),3977866). assertion_content_comment('tOboGo_EstablishmentOfOmmatidialPlanarPolarity',s("The","specification","of","polarized","ommatidia",".","Ommatidia","occur","in","two","chiral","forms",".","The","trapezoidal","arrangement","of","photoreceptors","in","the","dorsal","part","of","the","eye","is","the","mirror","image","of","that","in","the","ventral","part","."),4017835). assertion_content_comment('tOboGo_EstablishmentOfOocyteNucleusLocalizationInvolvedInOocyteDorsalVentralAxisSpecification',s("The","directed","movement","of","the","nucleus","to","a","specific","location","within","the","cell","during","the","establishment","and","maintenance","of","the","dorsal/ventral","axis","of","the","oocyte",".","In","the","insect","oocyte",",","for","example",",","the","nucleus","is","repositioned","to","a","dorso-anterior","position","."),4052053). assertion_content_comment('tOboGo_EstablishmentOfOrganelleLocalization',s("The","directed","movement","of","an","organelle","to","a","specific","location","."),3970026). assertion_content_comment('tOboGo_EstablishmentOfOrganOrientation',s("The","process","that","determines","the","orientation","of","an","organ","or","tissue","with","reference","to","an","axis","."),4102970). assertion_content_comment('tOboGo_EstablishmentOfPetalOrientation',s("The","process","that","determines","the","orientation","of","petals","with","reference","to","the","central","axis","."),4103141). assertion_content_comment('tOboGo_EstablishmentOfPigmentGranuleLocalization',s("The","directed","movement","of","a","pigment","granule","to","a","specific","location","."),4056459). assertion_content_comment('tOboGo_EstablishmentOfPlanarPolarityInvolvedInMesonephricNephronMorphogenesis',s("Coordinated","organization","of","groups","of","cells","in","the","plane","of","an","epithelium","that","contributes","to","the","shaping","of","a","nephron","in","the","mesonephros","."),4134062). assertion_content_comment('tOboGo_EstablishmentOfPlanarPolarityInvolvedInMetanephricNephronMorphogenesis',s("Coordinated","organization","of","groups","of","cells","in","the","plane","of","an","epithelium","that","contributes","to","the","shaping","of","a","nephron","in","the","metanephros","."),4124493). assertion_content_comment('tOboGo_EstablishmentOfPlanarPolarityInvolvedInNephronMorphogenesis',s("Coordinated","organization","of","groups","of","cells","in","the","plane","of","an","epithelium","that","contributes","to","the","shaping","of","a","nephron","."),4123667). assertion_content_comment('tOboGo_EstablishmentOfPlanarPolarityInvolvedInNeuralTubeClosure',s("Coordinated","organization","of","groups","of","cells","in","the","plane","of","an","epithelium","that","contributes","to","the","closure","of","the","neural","tube","."),4141635). assertion_content_comment('tOboGo_EstablishmentOfPlanarPolarityOfEmbryonicEpithelium',s("Coordinated","organization","of","groups","of","cells","in","the","plane","of","an","embryonic","epithelium",",","such","that","they","all","orient","to","similar","coordinates","."),4141631). assertion_content_comment('tOboGo_EstablishmentOfPlanarPolarityOfFollicularEpithelium',s("Coordinated","organization","of","groups","of","cells","in","the","plane","of","a","follicular","epithelium",",","such","that","they","all","orient","to","similar","coordinates","."),4314664). assertion_content_comment('tOboGo_EstablishmentOfPlanarPolarityOfLarvalImaginalDiscEpithelium',s("Coordinated","organization","of","groups","of","cells","in","the","plane","of","a","larval","imaginal","disc","epithelium",",","such","that","they","all","orient","to","similar","coordinates","."),4314617). assertion_content_comment('tOboGo_EstablishmentOfPlanarPolarity',s("Coordinated","organization","of","groups","of","cells","in","the","plane","of","an","epithelium",",","such","that","they","all","orient","to","similar","coordinates","."),3982329). assertion_content_comment('tOboGo_EstablishmentOfPlastidLocalization',s("The","directed","movement","of","a","plastid","to","a","specific","location","in","the","cell","."),4121818). assertion_content_comment('tOboGo_EstablishmentOfPolePlasmMRNALocalization',s("Any","process","that","results","in","the","directed","movement","of","mRNA","to","the","oocyte","pole","plasm","."),4098612). assertion_content_comment('tOboGo_EstablishmentOfPosteriorGapGeneBoundaries',s("Specification","of","the","borders","of","posterior","gap","gene","expression","mediated","largely","by","the","effects","of","other","gap","genes",";","in","insects","this","is","exemplified","by","hunchback","and","tailless","repression","of","knirps","."),4019421). assertion_content_comment('tOboGo_EstablishmentOfProteaseLocalizationInMastCellSecretoryGranule',s("The","directed","movement","of","a","protease","to","a","location","within","a","secretory","granule","in","a","mast","cell","."),4063287). assertion_content_comment('tOboGo_EstablishmentOfProteaseLocalizationInTCellSecretoryGranule',s("The","directed","movement","of","a","protease","to","a","location","within","a","secretory","granule","in","a","T","cell","."),4063206). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInEndoplasmicReticulum',s("The","directed","movement","of","a","protein","to","a","specific","location","in","the","endoplasmic","reticulum","."),4013885). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInExtracellularRegion',s("The","directed","movement","of","a","protein","to","a","specific","location","within","the","extracellular","region","."),4082157). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInGolgi',s("The","directed","movement","of","a","protein","to","a","specific","location","in","the","Golgi","apparatus","."),4126723). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInMastCellSecretoryGranule',s("The","directed","movement","of","a","protein","to","a","location","within","a","secretory","granule","in","a","mast","cell","."),4063276). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInMembrane',s("The","directed","movement","of","a","protein","to","a","specific","location","in","a","membrane","."),4149211). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInMitochondrialMembraneInvolvedInMitochondrialFission',s("The","directed","movement","of","a","protein","to","a","specific","location","in","the","mitochondrial","membrane","that","contributes","to","mitochondrial","fission","."),4149233). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInMitochondrialMembrane',s("The","directed","movement","of","a","protein","to","a","specific","location","in","the","mitochondrial","membrane","."),4149229). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInMitochondrion',s("The","directed","movement","of","a","protein","to","a","specific","location","in","the","mitochondrion","."),3986886). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInPlasmaMembrane',s("The","directed","movement","of","a","protein","to","a","specific","location","in","the","plasma","membrane","."),4149532). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationInTCellSecretoryGranule',s("The","directed","movement","of","a","protein","to","a","location","within","a","secretory","granule","in","a","T","cell","."),4063199). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalization',s("The","directed","movement","of","a","protein","to","a","specific","location","."),3970228). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToChloroplast',s("The","directed","movement","of","a","protein","to","a","specific","location","in","a","chloroplast","."),4126580). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToChromatin',s("The","directed","movement","of","a","protein","to","a","part","of","a","chromosome","that","is","organized","into","chromatin","."),4128767). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToChromosome',s("The","directed","movement","of","a","protein","to","a","specific","location","on","a","chromosome","."),4128763). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToJuxtaparanodeRegionOfAxon',s("The","directed","movement","of","a","protein","to","the","juxtaparanode","region","of","an","axon","."),4128855). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToOrganelle',s("The","directed","movement","of","a","protein","to","a","specific","location","on","or","in","an","organelle",".","Encompasses","establishment","of","localization","in","the","membrane","or","lumen","of","a","membrane-bounded","organelle","."),3986871). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToPeroxisome',s("The","directed","movement","of","a","protein","to","a","specific","location","in","a","peroxisome","."),4040615). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToSpindlePoleBody',s("The","directed","movement","of","a","protein","to","a","specific","location","at","the","spindle","pole","body","."),4125791). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToTelomere',s("The","directed","movement","of","a","protein","to","a","specific","location","in","the","telomeric","region","of","a","chromosome","."),4137414). assertion_content_comment('tOboGo_EstablishmentOfProteinLocalizationToVacuole',s("The","directed","movement","of","a","protein","to","a","specific","location","in","a","vacuole","."),4034718). assertion_content_comment('tOboGo_EstablishmentOfProximalDistalCellPolarity',s("The","specification","and","formation","of","the","polarity","of","a","cell","along","its","proximal/distal","axis","."),4071313). assertion_content_comment('tOboGo_EstablishmentOfRibosomeLocalization',s("The","directed","movement","of","the","ribosome","to","a","specific","location","."),3970040). assertion_content_comment('tOboGo_EstablishmentOfRNALocalization',s("The","directed","movement","of","RNA","to","a","specific","location","."),4009513). assertion_content_comment('tOboGo_EstablishmentOfSecretoryGranuleLocalization',s("The","directed","movement","of","a","secretory","granule","to","a","specific","location","."),4053966). assertion_content_comment('tOboGo_EstablishmentOfSisterChromatidCohesion',s("The","process","in","which","the","sister","chromatids","of","a","replicated","chromosome","become","joined","along","the","entire","length","of","the","chromosome","during","S","phase","."),4077008). assertion_content_comment('tOboGo_EstablishmentOfSpindleLocalization',s("The","directed","movement","of","the","spindle","to","a","specific","location","in","the","cell","."),4081770). assertion_content_comment('tOboGo_EstablishmentOfSpindleOrientation',s("Any","process","that","set","the","alignment","of","spindle","relative","to","other","cellular","structures","."),4118089). assertion_content_comment('tOboGo_EstablishmentOfSpindlePoleBodyLocalizationInNuclearEnvelope',s("A","process","in","which","a","spindle","pole","body","is","transported","to","a","specific","location","in","the","nuclear","envelope",".","A","spindle","pole","body","is","a","type","of","microtubule","organizing","center","found","in","fungal","cells","."),4169279). assertion_content_comment('tOboGo_EstablishmentOfSpindlePoleBodyLocalization',s("Any","process","in","which","a","spindle","pole","body","is","transported","to","a","specific","location",".","A","spindle","pole","body","is","a","type","of","microtubule","organizing","center","found","in","fungal","cells","."),4169274). assertion_content_comment('tOboGo_EstablishmentOfSynapticSpecificityAtNeuromuscularJunction',s("The","biological","process","in","which","a","synapse","between","a","motor","neuron","and","a","muscle","is","initially","formed","."),4018530). assertion_content_comment('tOboGo_EstablishmentOfTCellPolarity',s("The","directed","orientation","of","T","cell","signaling","molecules","and","associated","membrane","rafts","towards","a","chemokine","gradient","or","a","contact","point","with","antigen","presenting","cell","."),3984680). assertion_content_comment('tOboGo_EstablishmentOfTerminalGapGeneBoundary',s("Specification","of","the","borders","of","terminal","gap","gene","expression","mediated","largely","by","the","effects","of","other","gap","genes","."),4019394). assertion_content_comment('tOboGo_EstablishmentOfTissuePolarity',s("Coordinated","organization","of","groups","of","cells","in","a","tissue",",","such","that","they","all","orient","to","similar","coordinates","."),3982326). assertion_content_comment('tOboGo_EstablishmentOfTurgorInAppressorium',s("The","process","in","which","hydrostatic","pressure","is","increased","within","the","symbiont","appressorium","to","breach","the","cuticle","of","the","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146951). assertion_content_comment('tOboGo_EstablishmentOfVesicleLocalization',s("The","directed","movement","of","a","vesicle","to","a","specific","location","."),4004890). assertion_content_comment('tOboGo_EstablishmentOfViralLatency',s("The","process","in","which","a","virus","reaches","a","latent","state","."),4045208). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfActinCytoskeletonPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","polarized","actin-based","cytoskeletal","structures","."),4307360). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfApicalBasalCellPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","polarization","of","a","cell","'","s","architecture","along","its","apical/basal","axis","so","that","the","apical","and","basal","regions","of","the","cell","have","different","membrane",",","extracellular","matrix","and","sub-membrane","cellular","components","."),4002100). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfBipolarCellPolarityRegulatingCellShape',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","a","bipolar","intracellular","organization","or","cell","growth","patterns","that","regulates","the","shaping","of","a","cell","."),4133658). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfBipolarCellPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","a","bipolar","intracellular","organization","or","cell","growth","patterns","."),4002098). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfCellPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","anisotropic","intracellular","organization","or","cell","growth","patterns","."),3974016). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfCytoskeletonPolarityInvolvedInAmeboidalCellMigration',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","polarized","cytoskeletal","structures","that","contribute","to","the","cell","polarity","of","a","migrating","ameboid","cell","."),4005507). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfCytoskeletonPolarityInvolvedInGastrulation',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","polarized","cytoskeletal","structures","that","contribute","to","the","cell","polarity","of","a","migrating","ameboid","cell","taking","part","in","gastrulation","."),4005510). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfCytoskeletonPolarityInvolvedInMesendodermalCellMigration',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","polarized","cytoskeletal","structures","that","contribute","to","the","cell","polarity","of","a","migrating","ameboid","cell","."),4005646). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfCytoskeletonPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","polarized","cytoskeletal","structures","."),4005504). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfEpithelialCellApicalBasalPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","the","apicobasal","polarity","of","an","epithelial","cell","."),4002132). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfMicrotubuleCytoskeletonPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","polarized","microtubule-based","cytoskeletal","structures","."),4015081). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfMonopolarCellPolarityRegulatingInCellShape',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","a","monopolar","intracellular","organization","or","cell","growth","patterns","that","regulating","the","shape","of","a","cell","."),4261562). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfMonopolarCellPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","monopolar","intracellular","organization","or","cell","growth","patterns",".","Monopolar","cell","organization","is","directional","organization","along","an","axis","."),4002118). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfNeuroblastPolarity',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","the","apicobasal","polarity","of","a","neuroblast","cell",",","a","progenitor","of","the","central","nervous","system","."),4140450). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfPolarityOfEmbryonicEpithelium',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","anisotropic","intracellular","organization","of","epithelial","cells","in","an","embryo","."),4034560). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfPolarityOfFollicularEpithelium',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","a","polarized","follicular","epithelial","sheet","."),4014832). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfPolarityOfLarvalImaginalDiscEpithelium',s("Any","cellular","process","that","results","in","the","specification",",","formation","or","maintenance","of","a","polarized","larval","imaginal","disc","epithelium","."),4034550). assertion_content_comment('tOboGo_EstablishmentOrMaintenanceOfTransmembraneElectrochemicalGradient',s("The","directed","movement","of","ions","to","establish","or","maintain","an","electrochemical","gradient","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4335504). assertion_content_comment('tOboGo_EsterosomeLumen',s("The","volume","enclosed","by","the","membrane","of","an","esterosome","."),4074730). assertion_content_comment('tOboGo_EsterosomeMembrane',s("The","lipid","bilayer","surrounding","an","esterosome",".","This","membrane","has","characteristics","of","rough","endoplasmic","reticulum","(","RER",")","membranes","."),4065923). assertion_content_comment('tOboGo_Esterosome',s("A","vesicle","filled","with","crystalline","protein","that","shows","sequence","similarities","with","various","esterases","."),4065913). assertion_content_comment('tOboGo_Estivation',s("Any","process","in","which","an","organism","enters","and","maintains","a","period","of","dormancy",",","similar","to","hibernation",",","but","that","occurs","during","the","summer",".","It","insulates","against","heat","to","prevent","the","harmful","effects","of","the","season","."),4316880). assertion_content_comment('tOboGo_EstrogenBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","estrogens",",","C18","steroid","hormones","that","can","stimulate","the","development","of","female","sexual","characteristics",".","Also","found","in","plants","."),4229569). assertion_content_comment('tOboGo_EstrogenCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","estrogens",",","C18","steroid","hormones","that","can","stimulate","the","development","of","female","sexual","characteristics",".","Also","found","in","plants","."),4229708). assertion_content_comment('tOboGo_EstrogenMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","estrogens",",","C18","steroid","hormones","that","can","stimulate","the","development","of","female","sexual","characteristics",".","Also","found","in","plants","."),4229562). assertion_content_comment('tOboGo_EstrogenReceptorActivity',s("Combining","with","estrogen","to","initiate","a","change","in","cell","activity","."),4311882). assertion_content_comment('tOboGo_EstrogenReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","estrogen","receptor","."),4312151). assertion_content_comment('tOboGo_EstrogenReceptorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","an","estrogen","binding","to","its","receptor","."),4065572). assertion_content_comment('tOboGo_EstrogenResponseElementBinding',s("Interacting","selectively","and","non-covalently","with","the","estrogen","response","element","(","ERE",")",",","a","conserved","sequence","found","in","the","promoters","of","genes","whose","expression","is","regulated","in","response","to","estrogen","."),4360786). assertion_content_comment('tOboGo_EstroneSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","estrone","=","adenosine","3","'",",","5","'","-bisphosphate","+","estrone","3-sulfate","."),4209004). assertion_content_comment('tOboGo_EstrousCyclePhase',s("The","progression","of","physiological","phases",",","occurring","in","the","endometrium","during","the","estrous","cycle","that","recur","at","regular","intervals","during","the","reproductive","years",".","The","estrous","cycle","is","an","ovulation","cycle","where","the","endometrium","is","resorbed","if","pregnancy","does","not","occur","."),4160027). assertion_content_comment('tOboGo_Estrus',s("The","estrous","cycle","phase","in","which","a","female","is","sexually","receptive","."),4160134). assertion_content_comment('tOboGo_EthanolamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ethanolamine","(","2-aminoethanol",")",",","an","important","water-soluble","base","of","phospholipid","(","phosphatidylethanolamine",")"),4230399). assertion_content_comment('tOboGo_EthanolamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ethanolamine","(","2-aminoethanol",")",",","an","important","water-soluble","base","of","phospholipid","(","phosphatidylethanolamine",")"),4349998). assertion_content_comment('tOboGo_EthanolamineDegradationPolyhedralOrganelle',s("An","organelle","found","in","bacteria","consisting","of","a","proteinaceous","coat","containing","enzymes","for","the","degradation","of","ethanolamine","whose","purpose","is","the","protection","of","the","rest","of","the","cell","from","the","toxic","acetaldehyde","product","of","the","enzyme","ethanolamine","ammonia","lyase","."),4321637). assertion_content_comment('tOboGo_EthanolamineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","ethanolamine","=","ADP","+","2","H","(","+",")","+","phosphoethanolamine","."),4209021). 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assertion_content_comment('tOboGo_ExcitationOfVasomotorCenterByAorticBodyChemoreceptorSignaling',s("The","process","in","which","the","molecular","signal","from","an","aortic","body","is","relayed","to","the","vasomotor","center",",","causing","it","to","signal","an","increase","arterial","pressure","."),3999274). assertion_content_comment('tOboGo_ExcitationOfVasomotorCenterByBaroreceptorSignaling',s("The","process","in","which","the","molecular","signal","from","the","arterial","baroreceptors","is","relayed","to","the","vasomotor","center","causing","it","to","signal","increase","arterial","pressure","."),3991382). assertion_content_comment('tOboGo_ExcitationOfVasomotorCenterByCarotidBodyChemoreceptorSignaling',s("The","process","in","which","the","molecular","signal","from","a","carotid","body","is","relayed","to","the","vasomotor","center",",","causing","it","to","signal","an","increase","arterial","pressure","."),3999263). assertion_content_comment('tOboGo_ExcitationOfVasomotorCenterByChemoreceptorSignaling',s("The","process","in","which","the","molecular","signal","from","the","carotid","and","aortic","bodies","is","relayed","to","the","vasomotor","center",",","causing","it","to","signal","an","increase","arterial","pressure","."),3991361). assertion_content_comment('tOboGo_ExcitatorySynapse',s("A","synapse","in","which","an","action","potential","in","the","presynaptic","cell","increases","the","probability","of","an","action","potential","occurring","in","the","postsynaptic","cell","."),4159360). assertion_content_comment('tOboGo_Excretion',s("The","elimination","by","an","organism","of","the","waste","products","that","arise","as","a","result","of","metabolic","activity",".","These","products","include","water",",","carbon","dioxide","(","CO2",")",",","and","nitrogenous","compounds","."),4081071). assertion_content_comment('tOboGo_Exine',s("The","outer","layer","of","the","pollen","grain","wall","which","is","composed","primarily","of","sporopollenin","."),4094999). assertion_content_comment('tOboGo_ExitFromDiapause',s("The","dormancy","process","that","results","in","exit","from","diapause",".","Diapause","is","a","neurohormonally","mediated",",","dynamic","state","of","low","metabolic","activity",".","Associated","characteristics","of","this","form","of","dormancy","include","reduced","morphogenesis",",","increased","resistance","to","environmental","extremes",",","and","altered","or","reduced","behavioral","activity",".","Full","expression","develops","in","a","species-specific","manner",",","usually","in","response","to","a","number","of","environmental","stimuli","that","precede","unfavorable","conditions",".","Once","diapause","has","begun",",","metabolic","activity","is","suppressed","even","if","conditions","favorable","for","development","prevail",".","Once","initiated",",","only","certain","stimuli","are","capable","of","releasing","the","organism","from","this","state",",","and","this","characteristic","is","essential","in","distinguishing","diapause","from","hibernation","."),4094217). assertion_content_comment('tOboGo_ExitFromMitosis',s("The","cell","cycle","process","where","a","cell","leaves","M","phase",".","M","phase","is","the","part","of","the","mitotic","cell","cycle","during","which","mitosis","and","cytokinesis","take","place","."),3980333). assertion_content_comment('tOboGo_ExitFromReproductiveDiapause',s("The","dormancy","process","that","results","in","exit","from","reproductive","diapause",".","Reproductive","diapause","is","a","form","of","diapause","where","the","organism","itself","will","remain","fully","active",",","including","feeding","and","other","routine","activities",",","but","the","reproductive","organs","experience","a","tissue-specific","reduction","in","metabolism",",","with","characteristic","triggering","and","releasing","stimuli","."),4168822). assertion_content_comment('tOboGo_ExocrinePancreasDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","exocrine","pancreas","over","time",",","from","its","formation","to","the","mature","structure",".","The","exocrine","pancreas","produces","and","store","zymogens","of","digestive","enzymes",",","such","as","chymotrypsinogen","and","trypsinogen","in","the","acinar","cells","."),4061294). assertion_content_comment('tOboGo_ExocrineSystemDevelopment',s("Progression","of","the","exocrine","system","over","time",",","from","its","formation","to","a","mature","structure",".","The","exocrine","system","is","a","system","of","hormones","and","glands",",","where","the","glands","secrete","straight","to","a","target","site","via","ducts","or","tubes",".","The","human","exocrine","system","includes","the","salivary","glands",",","sweat","glands","and","many","glands","of","the","digestive","system","."),4017432). assertion_content_comment('tOboGo_ExocystAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","various","polypeptides","into","the","exocyst","complex","."),3988767). assertion_content_comment('tOboGo_ExocystLocalization',s("Any","process","in","which","an","exocyst","is","transported","to",",","or","maintained","in",",","a","specific","location",".","An","exocyst","is","a","protein","complex","peripherally","associated","with","the","plasma","membrane","that","determines","where","vesicles","dock","and","fuse","."),4108554). assertion_content_comment('tOboGo_Exocyst',s("A","protein","complex","peripherally","associated","with","the","plasma","membrane","that","determines","where","vesicles","dock","and","fuse",".","At","least","eight","complex","components","are","conserved","between","yeast","and","mammals","."),4346116). assertion_content_comment('tOboGo_ExocyticVesicle',s("A","transport","vesicle","that","mediates","transport","from","an","intracellular","compartment","to","the","plasma","membrane",",","and","fuses","with","the","plasma","membrane","to","release","various","cargo","molecules",",","such","as","proteins","or","hormones",",","by","exocytosis","."),4172958). assertion_content_comment('tOboGo_ExodeoxyribonucleaseActivity',s("Catalysis","of","the","sequential","cleavage","of","mononucleotides","from","a","free","5","'","or","3","'","terminus","of","a","DNA","molecule","."),4183297). assertion_content_comment('tOboGo_ExodeoxyribonucleaseIActivity',s("Catalysis","of","the","degradation","of","single-stranded","DNA",".","It","acts","progressively","in","a","3","'","to","5","'","direction",",","releasing","5","'","-phosphomononucleotides","."),4250116). assertion_content_comment('tOboGo_ExodeoxyribonucleaseIIIActivity',s("Catalysis","of","the","degradation","of","double-stranded","DNA",".","It","acts","progressively","in","a","3","'","to","5","'","direction",",","releasing","5","'","-phosphomononucleotides","."),4250101). assertion_content_comment('tOboGo_ExodeoxyribonucleaseVActivity',s("Catalysis","of","the","exonucleolytic","cleavage","(","in","the","presence","of","ATP",")","in","either","5","'","to","3","'","or","3","'","to","5","'","direction","to","yield","5","'","-phosphooligonucleotides","."),4250041). assertion_content_comment('tOboGo_ExodeoxyribonucleaseVComplex',s("An","enzyme","complex","that","catalyzes","exonucleolytic","cleavage","(","in","the","presence","of","ATP",")","in","either","5","'","to","3","'","or","3","'","to","5","'","direction","to","yield","5","'","-phosphooligonucleotides",".","Exodeoxyribonuclease","V","shows","a","preference","for","double-stranded","DNA","and","possesses","DNA-dependent","ATPase","activity",".","It","acts","endonucleolytically","on","single-stranded","circular","DNA","."),4259781). assertion_content_comment('tOboGo_ExodeoxyribonucleaseVIIActivity',s("Catalysis","of","the","exonucleolytic","cleavage","in","either","5","'","to","3","'","or","3","'","to","5","'","direction","to","yield","5","'","-phosphomononucleotides","."),4250026). assertion_content_comment('tOboGo_ExodeoxyribonucleaseVIIComplex',s("An","enzyme","complex","that","catalyzes","exonucleolytic","cleavage","in","either","5","'","to","3","'","or","3","'","to","5","'","direction","to","yield","nucleoside","5","'","-phosphates",";","it","prefers","single-stranded","DNA","."),4259912). assertion_content_comment('tOboGo_ExodeoxyribonucleaseXActivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","supercoiled","plasma","DNA","to","linear","DNA","duplexes","."),4250058). assertion_content_comment('tOboGo_ExogenousAntibioticCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","an","antibiotic","that","has","originated","externally","to","the","cell","or","organism","."),4077334). assertion_content_comment('tOboGo_ExogenousDrugCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","drug","that","has","originated","externally","to","the","cell","or","organism","."),4077308). assertion_content_comment('tOboGo_ExogenousLipidAntigenBinding',s("Interacting","selectively","and","non-covalently","with","an","exogenous","lipid","antigen","(","examples","include","microbial","lipids","and","glycolipids",")"),4307112). assertion_content_comment('tOboGo_ExogenousPeptideReceptorActivity',s("OBSOLETE",".","Combining","with","an","extracellular","peptide","to","initiate","a","change","in","cell","activity","."),4254860). assertion_content_comment('tOboGo_Exogen',s("The","shedding","phase","of","the","hair","cycle","."),4077916). assertion_content_comment('tOboGo_ExomerComplex',s("A","protein","complex","that","forms","a","coat","structure","on","vesicles","involved","in","exocytosis","of","proteins","from","the","trans-Golgi","network","to","the","cell","surface",";","in","Saccharomyces",",","the","complex","contains","Chs5p",",","Chs6p",",","and","Chs6p","paralogues","."),4077118). assertion_content_comment('tOboGo_Exoneme',s("A","dense","granule-like","organelle","of","the","apical","complex","of","merozoites",",","released","into","the","parasitophorous","vacuole",",","mediating","protease-dependent","rupture","and","parasite","exit","from","the","infected","erythrocyte","."),4096876). assertion_content_comment('tOboGo_ExonucleaseActivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","nucleic","acids","by","removing","nucleotide","residues","from","the","3","'","or","5","'","end","."),4183281). assertion_content_comment('tOboGo_ExonucleolyticTrimmingInvolvedInRRNAProcessing',s("Exonucleolytic","digestion","of","a","pre-rRNA","molecule","in","the","process","to","generate","a","mature","rRNA","molecule","."),3976139). assertion_content_comment('tOboGo_ExopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","a","peptide","bond","not","more","than","three","residues","from","the","N-","or","C-terminus","of","a","polypeptide","chain",",","in","a","reaction","that","requires","a","free","N-terminal","amino","group",",","C-terminal","carboxyl","group","or","both","."),4168567). assertion_content_comment('tOboGo_ExopolyphosphataseActivity',s("Catalysis","of","the","reaction",":","polyphosphate","(","n",")","+","H2O","=","polyphosphate","(","n-1",")","+","phosphate","."),4208705). assertion_content_comment('tOboGo_ExoribonucleaseActivity',s("Catalysis","of","the","sequential","cleavage","of","mononucleotides","from","a","free","5","'","or","3","'","terminus","of","an","RNA","molecule","."),4204876). assertion_content_comment('tOboGo_ExoribonucleaseHActivity',s("Catalysis","of","the","exonucleolytic","cleavage","of","RNA","to","5","'","-phosphomonoester","oligonucleotides","in","both","5","'","to","3","'","and","3","'","to","5","'","directions","."),4204907). assertion_content_comment('tOboGo_ExoribonucleaseIIActivity',s("Catalysis","of","the","reaction",":","RNA","+","H2O","=","5","'","-phosphomononucleotides",".","Cleaves","RNA","in","the","3","'","to","5","'","direction","."),4250072). assertion_content_comment('tOboGo_ExosomeRNaseComplex',s("Complex","of","3","'","-5","'","exoribonucleases","."),3972776). assertion_content_comment('tOboGo_ExosporiumAssembly',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","formation","of","an","exosporium",",","the","outermost","layer","of","a","bacterial","endospore","."),4175719). assertion_content_comment('tOboGo_Exosporium',s("The","outermost","layer","of","a","bacterial","endospore",",","which","is","loosely","attached","and","located","outside","of","the","endospore","coat",".","It","is","generally","composed","of","protein",",","carbohydrate",",","and","perhaps","lipid","."),4094747). assertion_content_comment('tOboGo_ExotoxinActivity',s("OBSOLETE",".","The","function","of","a","toxin","formed","by","a","microorganism","and","secreted","into","the","surrounding","medium","."),4233702). assertion_content_comment('tOboGo_Expansin',s("OBSOLETE",".","A","group","of","proteins","located","within","the","cell","walls","of","plants",",","both","dicots","and","grasses",",","that","play","an","essential","role","in","loosening","cell","walls","during","cell","growth",".","They","are","hydrophobic",",","non","glycosylated","proteins","of","about","30kDa","."),4261811). assertion_content_comment('tOboGo_ExplorationBehavior',s("The","specific","actions","or","reactions","of","an","organism","in","response","to","a","novel","environment","or","stimulus","."),4379993). assertion_content_comment('tOboGo_Exportin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220201). assertion_content_comment('tOboGo_ExtensinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","extensins",",","a","group","of","60-90","kDNA","hydroxyproline","(","Hyp",")","-rich","glycoproteins","whose","polypeptide","backbone","consists","of","many","repeats","of","structural","Ser","(","Hyp",")","4-6","motifs",",","with","heavily","glycosylated","1-4","arabinose","residues","O-linked","to","contiguous","stretches","of","Hyp","residues",",","with","most","of","the","Ser","residues","being","O-galactosylated","."),4332991). assertion_content_comment('tOboGo_ExtensionOfALeadingProcessInvolvedInCellLocomotionInCerebralCortexRadialGliaGuidedMigration',s("The","rearrangements","of","the","microtubule","cytoskeleton","that","result","in","the","extension","of","a","leading","process",",","where","this","process","is","involved","in","the","movement","of","cells","along","radial","glial","cells","."),4049764). assertion_content_comment('tOboGo_ExternalEncapsulatingStructureOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","external","structures","that","lie","outside","the","plasma","membrane","and","surround","the","entire","cell","."),4021683). assertion_content_comment('tOboGo_ExternalEncapsulatingStructurePart',s("Any","constituent","part","of","an","external","encapsulating","structure",",","a","structure","that","lies","outside","the","plasma","membrane","and","surrounds","the","entire","cell","."),4006913). assertion_content_comment('tOboGo_ExternalEncapsulatingStructure',s("A","structure","that","lies","outside","the","plasma","membrane","and","surrounds","the","entire","cell","."),4006880). assertion_content_comment('tOboGo_ExternalGenitaliaMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","external","genitalia","are","generated","and","organized",".","The","external","genitalia","are","the","outer","sex","organs",",","such","as","the","penis","or","vulva","in","mammals","."),4382682). assertion_content_comment('tOboGo_ExternalSideOfCellOuterMembrane',s("The","side","of","the","outer","membrane","that","is","opposite","to","the","side","that","faces","the","periplasm","of","the","cell","."),4062219). assertion_content_comment('tOboGo_ExternalSideOfCellWall',s("The","side","of","the","cell","wall","that","is","opposite","to","the","side","that","faces","the","cell","and","its","contents","."),4031426). assertion_content_comment('tOboGo_ExternalSideOfEndosomeMembrane',s("The","external","(","cytoplasmic","face",")","of","an","endosome","membrane","."),4033393). assertion_content_comment('tOboGo_ExternalSideOfMitochondrialOuterMembrane',s("The","external","(","cytoplasmic","face",")","of","the","mitochondrial","outer","membrane","."),4334889). assertion_content_comment('tOboGo_ExternalSideOfPlasmaMembrane',s("The","side","of","the","plasma","membrane","that","is","opposite","to","the","side","that","faces","the","cytoplasm","."),4021261). assertion_content_comment('tOboGo_ExtracellularAminoAcidTransport',s("The","directed","extracellular","movement","of","amino","acids","."),4228744). assertion_content_comment('tOboGo_ExtracellularCarbohydrateTransport',s("The","directed","extracellular","movement","of","carbohydrates","."),4228734). assertion_content_comment('tOboGo_ExtracellularFerritinComplex',s("A","ferritin","complex","located","in","the","extracellular","region",".","Extracellular","ferritin","complexes","contain","L","(","light",")","chains","but","few","or","no","H","(","heavy",")","chains","."),4174102). assertion_content_comment('tOboGo_ExtracellularIsoamylaseComplex',s("A","protein","complex","whose","composition","varies","amongst","species",";","in","rice","it","probably","exists","in","a","homo-tetramer","to","homo-hexamer","form","and","in","Gram","negative","bacteria","as","a","dimer",".","Functions","in","the","hydrolysis","of","alpha-","(","1",",","6",")","-D-glucosidic","branch","linkages",".","Isoamylases","in","animals","are","localized","in","the","extracellular","space","."),4332096). assertion_content_comment('tOboGo_ExtracellularMatrixAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","the","extracellular","matrix","."),4018738). assertion_content_comment('tOboGo_ExtracellularMatrixBinding',s("Interacting","selectively","and","non-covalently","with","a","component","of","the","extracellular","matrix","."),4274680). assertion_content_comment('tOboGo_ExtracellularMatrixConstituentConferringElasticity',s("A","component","of","the","extracellular","matrix","that","enables","the","matrix","to","recoil","after","transient","stretching","."),4306812). assertion_content_comment('tOboGo_ExtracellularMatrixConstituentLubricantActivity',s("Functions","as","a","lubricant","for","an","extracellular","matrix",",","such","as","a","mucous","membrane","."),4311345). assertion_content_comment('tOboGo_ExtracellularMatrixConstituentSecretion',s("The","controlled","release","of","molecules","that","form","the","extracellular","matrix",",","including","carbohydrates","and","glycoproteins","by","a","cell","or","a","group","of","cells","."),4006370). assertion_content_comment('tOboGo_ExtracellularMatrixDisassembly',s("A","process","that","results","in","the","breakdown","of","the","extracellular","matrix","."),4026906). assertion_content_comment('tOboGo_ExtracellularMatrixGlycoprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217785). assertion_content_comment('tOboGo_ExtracellularMatrixOrganizationInMarginalZoneInvolvedInCerebralCortexRadialGliaGuidedMigration',s("The","process","that","leads","to","the","deposition","of","extracellular","matrix","signals","in","the","marginal","zone","of","the","developing","cerebral","cortex",".","This","extracellular","matrix","controls","the","movement","of","migrating","cells",".","In","mammals",",","the","matrix","is","modified","by","Cajal-Retzius","cells","."),4051469). assertion_content_comment('tOboGo_ExtracellularMatrixOrganizationInvolvedInEndocardiumDevelopment',s("A","process","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","extracellular","matrix","of","the","endocardium",".","The","endocardium","is","an","anatomical","structure","comprised","of","an","endothelium","and","an","extracellular","matrix","that","forms","the","innermost","layer","of","tissue","of","the","heart",",","and","lines","the","heart","chambers","."),4135582). assertion_content_comment('tOboGo_ExtracellularMatrixOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","extracellular","matrix","."),4006366). assertion_content_comment('tOboGo_ExtracellularMatrixPart',s("Any","constituent","part","of","the","extracellular","matrix",",","the","structure","lying","external","to","one","or","more","cells",",","which","provides","structural","support","for","cells","or","tissues",";","may","be","completely","external","to","the","cell","(","as","in","animals",")","or","be","part","of","the","cell","(","as","often","seen","in","plants",")"),4006832). assertion_content_comment('tOboGo_ExtracellularMatrix',s("A","structure","lying","external","to","one","or","more","cells",",","which","provides","structural","support","for","cells","or","tissues",";","may","be","completely","external","to","the","cell","(","as","in","animals",")","or","be","part","of","the","cell","(","as","in","plants",")"),4006811). assertion_content_comment('tOboGo_ExtracellularMatrixStructuralConstituentConferringCompressionResistance',s("A","constituent","of","the","extracellular","matrix","that","enables","the","matrix","to","resist","compressive","forces",";","often","a","proteoglycan","."),4306836). assertion_content_comment('tOboGo_ExtracellularMatrixStructuralConstituentConferringTensileStrength',s("A","constituent","of","the","extracellular","matrix","that","enables","the","matrix","to","resist","longitudinal","stress","."),4306845). assertion_content_comment('tOboGo_ExtracellularMatrixStructuralConstituent',s("The","action","of","a","molecule","that","contributes","to","the","structural","integrity","of","the","extracellular","matrix","."),4217781). assertion_content_comment('tOboGo_ExtracellularOrganelle',s("Organized","structure","of","distinctive","morphology","and","function",",","occurring","outside","the","cell",".","Includes",",","for","example",",","extracellular","membrane","vesicles","(","EMVs",")","and","the","cellulosomes","of","anaerobic","bacteria","and","fungi","."),4041897). assertion_content_comment('tOboGo_ExtracellularPolysaccharideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","polysaccharides","used","in","extracellular","structures","."),4298908). assertion_content_comment('tOboGo_ExtracellularPolysaccharideCatabolicProcessInvolvedInAscosporeReleaseFromAscus',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","polysaccharides","in","the","ascus","wall","that","contributes","to","the","release","of","ascospores","from","the","ascus","."),4125742). assertion_content_comment('tOboGo_ExtracellularPolysaccharideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","polysaccharides","used","in","extracellular","structures","."),4125736). assertion_content_comment('tOboGo_ExtracellularPolysaccharideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","polysaccharides","used","in","extracellular","structures","."),4125733). assertion_content_comment('tOboGo_ExtracellularRegionPart',s("Any","constituent","part","of","the","extracellular","region",",","the","space","external","to","the","outermost","structure","of","a","cell",".","For","cells","without","external","protective","or","external","encapsulating","structures","this","refers","to","space","outside","of","the","plasma","membrane",".","This","term","covers","constituent","parts","of","the","host","cell","environment","outside","an","intracellular","parasite","."),4006809). 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assertion_content_comment('tOboGo_ExtracellularSequesteringOfReceptorLigand',s("The","process","of","binding","or","confining","a","ligand","for","a","receptor","within","the","extracellular","region",",","such","that","it","is","separated","from","other","components","of","the","signaling","pathway","."),4378287). assertion_content_comment('tOboGo_ExtracellularSpaceOfHost',s("The","space","within","a","host","but","external","to","the","plasma","membrane","of","host","cells",",","e.g",".","within","host","bloodstream","."),4083815). assertion_content_comment('tOboGo_ExtracellularSpace',s("That","part","of","a","multicellular","organism","outside","the","cells","proper",",","usually","taken","to","be","outside","the","plasma","membranes",",","and","occupied","by","fluid","."),4006931). assertion_content_comment('tOboGo_ExtracellularStructureOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","structures","in","the","space","external","to","the","outermost","structure","of","a","cell",".","For","cells","without","external","protective","or","external","encapsulating","structures","this","refers","to","space","outside","of","the","plasma","membrane",",","and","also","covers","the","host","cell","environment","outside","an","intracellular","parasite","."),4006362). assertion_content_comment('tOboGo_ExtracellularTransport',s("The","transport","of","substances","that","occurs","outside","cells","."),4228723). assertion_content_comment('tOboGo_ExtracellularVesicularExosomeAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","extracellular","vesicular","exosome",",","a","membrane-bounded","vesicle","that","is","released","into","the","extracellular","region","by","fusion","of","the","limiting","endosomal","membrane","of","a","multivesicular","body","with","the","plasma","membrane","."),4168507). assertion_content_comment('tOboGo_ExtracellularVesicularExosome',s("A","membrane-bounded","vesicle","that","is","released","into","the","extracellular","region","by","fusion","of","the","limiting","endosomal","membrane","of","a","multivesicular","body","with","the","plasma","membrane","."),4180012). assertion_content_comment('tOboGo_ExtrachromosomalCircularDNAAccumulationInvolvedInCellAging',s("Increase","in","abundance",",","as","cells","age",",","of","circular","DNA","molecules","that","originate","in","the","chromosome","but","are","excised","and","circularized",",","often","by","intramolecular","homologous","recombination","between","direct","tandem","repeats",",","and","replicated","independently","of","chromosomal","replication","."),3979894). assertion_content_comment('tOboGo_ExtrachromosomalCircularDNAAccumulationInvolvedInReplicativeCellAging',s("Increase","in","abundance","of","circular","DNA","molecules","in","dividing","cells","as","they","age",".","These","molecules","originate","in","the","chromosome","but","are","excised","and","circularized",",","often","by","intramolecular","homologous","recombination","between","direct","tandem","repeats",",","and","then","replicated","independently","of","chromosomal","replication","."),3979898). assertion_content_comment('tOboGo_ExtrachromosomalCircularDNALocalizationInvolvedInCellAging',s("A","process","in","which","extrachromosomal","circular","DNA","molecules","are","transported","to",",","or","maintained","in",",","a","specific","location","in","cells","contributing","to","their","aging","."),4353841). assertion_content_comment('tOboGo_ExtrachromosomalCircularDNA',s("Circular","DNA","structures","that","are","not","part","of","a","chromosome","."),4007990). assertion_content_comment('tOboGo_ExtrachromosomalDNA',s("DNA","structures","that","are","not","part","of","a","chromosome","."),4007979). assertion_content_comment('tOboGo_ExtrachromosomalRDNACircleAccumulationInvolvedInReplicativeCellAging',s("Increase","in","abundance","of","circular","DNA","molecules","containing","ribosomal","DNA","repeats","in","dividing","cells","as","they","age",".","These","molecules","originate","in","the","chromosome","but","are","excised","and","circularized",",","often","by","intramolecular","homologous","recombination","between","direct","tandem","repeats",",","and","then","replicated","independently","of","chromosomal","replication","."),3979902). assertion_content_comment('tOboGo_ExtrachromosomalRDNACircle',s("Circular","DNA","molecules","encoding","ribosomal","RNA","that","are","replicated","independently","of","chromosomal","replication",".","These","molecules","originate","in","the","chromosome","but","are","excised","and","circularized",",","often","by","intramolecular","homologous","recombination","between","direct","tandem","repeats","."),4219856). assertion_content_comment('tOboGo_ExtraglomerularMesangialCellProliferation',s("The","multiplication","or","reproduction","of","extraglomerular","glomerular","mesangium","cells","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","Extraglomerular","mesangial","cells","(","also","known","as","lacis","cells",",","Goormaghtigh","cells",")","are","light-staining","cells","in","the","kidney","found","outside","the","glomerulus",",","near","the","vascular","pole","and","macula","densa","."),4122673). assertion_content_comment('tOboGo_ExtrahaustorialMatrix',s("The","space","between","the","symbiont","plasma","membrane","and","the","extrahaustorial","membrane","of","the","host","."),4083818). assertion_content_comment('tOboGo_ExtrahaustorialMembrane',s("The","membrane","surrounding","the","symbiont","haustorium","during","symbiosis",",","derived","from","the","host","plasma","membrane","."),4083965). assertion_content_comment('tOboGo_ExtraocularSkeletalMuscleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","extraocular","skeletal","muscle","over","time",",","from","its","formation","to","the","mature","structure",".","The","extraocular","muscle","is","derived","from","cranial","mesoderm","and","controls","eye","movements",".","The","muscle","begins","its","development","with","the","differentiation","of","the","muscle","cells","and","ends","with","the","mature","muscle",".","An","example","of","this","process","is","found","in","Mus","musculus","."),3990142). assertion_content_comment('tOboGo_ExtraorganismalSpace',s("The","environmental","space","outside","of","an","organism",";","this","may","be","a","host","organism","in","the","case","of","parasitic","and","symbiotic","organisms","."),4041784). assertion_content_comment('tOboGo_ExtrathymicTCellDifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","T","cell","via","a","differentiation","pathway","independent","of","the","thymus","."),4066086). assertion_content_comment('tOboGo_ExtrathymicTCellSelection',s("The","process","of","T","cell","selection","that","occurs","in","extrathymic","locations",",","often","resulting","T","cells","of","distinct","specificities","from","those","selected","in","the","thymus","."),4097088). assertion_content_comment('tOboGo_ExtrinsicToCellOuterMembrane',s("Loosely","bound","to","one","surface","of","the","outer","membrane","of","the","cell",",","but","not","integrated","into","the","hydrophobic","region","."),4062381). assertion_content_comment('tOboGo_ExtrinsicToEndoplasmicReticulumMembrane',s("Loosely","bound","to","one","surface","of","the","endoplasmic","reticulum","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4078425). assertion_content_comment('tOboGo_ExtrinsicToEndosomeMembrane',s("Loosely","bound","to","one","surface","of","the","endosome","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4059439). assertion_content_comment('tOboGo_ExtrinsicToExternalSideOfCellOuterMembrane',s("Loosely","bound","to","the","surface","of","the","outer","membrane","of","the","cell","that","faces","away","from","the","cytoplasm",",","but","not","integrated","into","the","hydrophobic","region","."),4062384). assertion_content_comment('tOboGo_ExtrinsicToExternalSideOfPlasmaMembraneInPeriplasmicSpace',s("Located","in","the","periplasmic","space","and","loosely","bound","to","the","surface","of","the","plasma","membrane","that","faces","away","from","the","cytoplasm",",","but","not","integrated","into","the","hydrophobic","region","."),4062194). assertion_content_comment('tOboGo_ExtrinsicToExternalSideOfPlasmaMembrane',s("Loosely","bound","to","the","surface","of","the","plasma","membrane","that","faces","away","from","the","cytoplasm",",","but","not","integrated","into","the","hydrophobic","region","."),4062139). assertion_content_comment('tOboGo_ExtrinsicToInternalSideOfCellOuterMembrane',s("Loosely","bound","to","the","surface","of","the","outer","membrane","of","the","cell","that","faces","the","cytoplasm",",","but","not","integrated","into","the","hydrophobic","region","."),4062421). assertion_content_comment('tOboGo_ExtrinsicToInternalSideOfPlasmaMembrane',s("Loosely","bound","to","the","surface","of","the","plasma","membrane","that","faces","the","cytoplasm",",","but","not","integrated","into","the","hydrophobic","region","."),4062171). assertion_content_comment('tOboGo_ExtrinsicToIntraperoxisomalMembrane',s("Loosely","bound","to","the","intraperoxisomal","surface","of","the","peroxisomal","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4007325). assertion_content_comment('tOboGo_ExtrinsicToLumenalSideOfPlastidThylakoidMembrane',s("Loosely","bound","to","the","surface","of","a","plastid","thylakoid","membrane","that","faces","the","lumen","but","not","integrated","into","the","hydrophobic","region","."),4375968). assertion_content_comment('tOboGo_ExtrinsicToLysosomeMembrane',s("Loosely","bound","to","one","surface","of","the","lysosome","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4055635). assertion_content_comment('tOboGo_ExtrinsicToMembrane',s("Loosely","bound","to","one","surface","of","a","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),3974589). assertion_content_comment('tOboGo_ExtrinsicToMitochondrialInnerMembrane',s("Loosely","bound","to","one","surface","of","the","mitochondrial","inner","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4059428). assertion_content_comment('tOboGo_ExtrinsicToMitochondrialOuterMembrane',s("Loosely","bound","to","one","surface","of","the","mitochondrial","outer","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4319644). assertion_content_comment('tOboGo_ExtrinsicToNuclearOuterMembrane',s("Loosely","bound","to","one","surface","of","the","nuclear","outer","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4059331). assertion_content_comment('tOboGo_ExtrinsicToOrganelleMembrane',s("Loosely","bound","to","one","surface","of","an","organelle","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),3974594). assertion_content_comment('tOboGo_ExtrinsicToPlasmaMembrane',s("Loosely","bound","to","one","surface","of","the","plasma","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4033922). assertion_content_comment('tOboGo_ExtrinsicToPlastidInnerMembrane',s("Loosely","bound","to","one","surface","of","a","plastid","inner","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4084652). assertion_content_comment('tOboGo_ExtrinsicToPlastidMembrane',s("Loosely","bound","to","one","surface","of","a","plastid","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4084641). assertion_content_comment('tOboGo_ExtrinsicToPlastidThylakoidMembrane',s("Loosely","bound","to","one","surface","of","a","plastid","thylakoid","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4084676). assertion_content_comment('tOboGo_ExtrinsicToStromalSideOfPlastidInnerMembrane',s("Loosely","bound","to","the","surface","of","a","plastid","inner","membrane","that","faces","the","stroma",",","but","not","integrated","into","the","hydrophobic","region","."),4375992). assertion_content_comment('tOboGo_ExtrinsicToStromalSideOfPlastidThylakoidMembrane',s("Loosely","bound","to","the","surface","of","a","plastid","thylakoid","membrane","that","faces","the","stroma","but","not","integrated","into","the","hydrophobic","region","."),4375948). assertion_content_comment('tOboGo_ExtrinsicToThylakoidMembrane',s("Loosely","bound","to","one","surface","of","a","thylakoid","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),4084664). assertion_content_comment('tOboGo_ExtrinsicToVacuolarMembrane',s("Loosely","bound","to","one","or","the","other","surface","of","the","vacuolar","membrane",",","but","not","integrated","into","the","hydrophobic","region","."),3974598). assertion_content_comment('tOboGo_EyeBlinkReflex',s("The","reflex","process","in","which","a","mechanical","stimulus","applied","to","the","eye","elicits","a","response","of","the","eyelid","closing","."),4159434). assertion_content_comment('tOboGo_EyeDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","eye","over","time",",","from","its","formation","to","the","mature","structure",".","The","eye","is","the","organ","of","sight","."),3984894). assertion_content_comment('tOboGo_EyeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","eye","are","generated","and","organized","."),3984896). assertion_content_comment('tOboGo_EyePhotoreceptorCellDevelopment',s("Development","of","a","photoreceptor",",","a","sensory","cell","in","the","eye","that","reacts","to","the","presence","of","light",".","They","usually","contain","a","pigment","that","undergoes","a","chemical","change","when","light","is","absorbed",",","thus","stimulating","a","nerve","."),4078694). assertion_content_comment('tOboGo_EyePhotoreceptorCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","photoreceptor","cell",",","as","found","in","the","eye",",","the","primary","visual","organ","of","most","organisms","."),3984957). assertion_content_comment('tOboGo_EyePhotoreceptorCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","an","eye","photoreceptor","cell",".","A","photoreceptor","cell","is","a","cell","that","responds","to","incident","electromagnetic","radiation",".","Different","classes","of","photoreceptor","have","different","spectral","sensitivities","and","express","different","photosensitive","pigments","."),3985255). assertion_content_comment('tOboGo_EyePigmentation',s("Establishment","of","a","pattern","of","pigment","in","the","eye","of","an","organism","."),4078469). assertion_content_comment('tOboGo_EyePigmentBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","eye","pigments",",","any","general","or","particular","coloring","matter","in","living","organisms",",","found","or","utilized","in","the","eye","."),4229387). assertion_content_comment('tOboGo_EyePigmentCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","eye","pigments",",","any","general","or","particular","coloring","matter","in","living","organisms",",","found","or","utilized","in","the","eye","."),4351980). assertion_content_comment('tOboGo_EyePigmentGranuleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","intracellular","pigment","storage","granules","in","the","eye","."),4246795). assertion_content_comment('tOboGo_EyePigmentMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","eye","pigments",",","any","general","or","particular","coloring","matter","in","living","organisms",",","found","or","utilized","in","the","eye","."),4078503). assertion_content_comment('tOboGo_EyePigmentPrecursorTransporterActivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","eye","pigment","precursor","(","in",")","=","ADP","+","phosphate","+","eye","pigment","precursor","(","out",")"),4219161). assertion_content_comment('tOboGo_EyePigmentPrecursorTransport',s("The","directed","movement","of","eye","pigment","precursors",",","the","inactive","forms","of","visual","pigments",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4011794). assertion_content_comment('tOboGo_F420H2DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","methanophenazine","+","reduced","cofactor","F420","=","dihydromethanophenazine","+","cofactor","F420","."),4325902). assertion_content_comment('tOboGo_FaceDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","face","from","an","initial","condition","to","its","mature","state",".","The","face","is","the","ventral","division","of","the","head","."),4114761). assertion_content_comment('tOboGo_FaceMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","face","are","generated","and","organized",".","The","face","is","the","ventral","division","of","the","head","."),4114772). assertion_content_comment('tOboGo_FacialNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","facial","nerve","over","time",",","from","its","formation","to","the","mature","structure",".","This","sensory","and","motor","nerve","supplies","the","muscles","of","facial","expression","and","the","expression","and","taste","at","the","anterior","two-thirds","of","the","tongue",".","The","principal","branches","are","the","superficial","opthalmic",",","buccal",",","palatine","and","hyomandibular",".","The","main","trunk","synapses","within","pterygopalatine","ganglion","in","the","parotid","gland","and","this","ganglion","then","gives","off","nerve","branches","which","supply","the","lacrimal","gland","and","the","mucous","secreting","glands","of","the","nasal","and","oral","cavities","."),4044771). assertion_content_comment('tOboGo_FacialNerveFormation',s("The","process","that","gives","rise","to","the","facial","nerve",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","This","sensory","and","motor","nerve","supplies","the","muscles","of","facial","expression","and","the","expression","and","taste","at","the","anterior","two-thirds","of","the","tongue",".","The","principal","branches","are","the","superficial","opthalmic",",","buccal",",","palatine","and","hyomandibular",".","The","main","trunk","synapses","within","pterygopalatine","ganglion","in","the","parotid","gland","and","this","ganglion","then","gives","of","nerve","branches","which","supply","the","lacrimal","gland","and","the","mucous","secreting","glands","of","the","nasal","and","oral","cavities","."),4044809). assertion_content_comment('tOboGo_FacialNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","facial","nerve","to","attain","its","fully","functional","state",".","This","sensory","and","motor","nerve","supplies","the","muscles","of","facial","expression","and","the","expression","and","taste","at","the","anterior","two-thirds","of","the","tongue",".","The","principal","branches","are","the","superficial","opthalmic",",","buccal",",","palatine","and","hyomandibular",".","The","main","trunk","synapses","within","pterygopalatine","ganglion","in","the","parotid","gland","and","this","ganglion","then","gives","of","nerve","branches","which","supply","the","lacrimal","gland","and","the","mucous","secreting","glands","of","the","nasal","and","oral","cavities","."),4044822). assertion_content_comment('tOboGo_FacialNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","facial","nerve","is","generated","and","organized",".","This","sensory","and","motor","nerve","supplies","the","muscles","of","facial","expression","and","the","expression","and","taste","at","the","anterior","two-thirds","of","the","tongue",".","The","principal","branches","are","the","superficial","opthalmic",",","buccal",",","palatine","and","hyomandibular",".","The","main","trunk","synapses","within","pterygopalatine","ganglion","in","the","parotid","gland","and","this","ganglion","then","gives","of","nerve","branches","which","supply","the","lacrimal","gland","and","the","mucous","secreting","glands","of","the","nasal","and","oral","cavities","."),4044785). assertion_content_comment('tOboGo_FacialNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","facial","nerve",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","This","sensory","and","motor","nerve","supplies","the","muscles","of","facial","expression","and","the","expression","and","taste","at","the","anterior","two-thirds","of","the","tongue",".","The","principal","branches","are","the","superficial","opthalmic",",","buccal",",","palatine","and","hyomandibular",".","The","main","trunk","synapses","within","pterygopalatine","ganglion","in","the","parotid","gland","and","this","ganglion","then","gives","of","nerve","branches","which","supply","the","lacrimal","gland","and","the","mucous","secreting","glands","of","the","nasal","and","oral","cavities","."),4044834). 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assertion_content_comment('tOboGo_FactorXIIActivation',s("Any","process","that","activates","Factor","XII","(","Hageman","factor",")","Factor","XII","is","a","protein","synthesized","by","the","liver","that","circulates","in","an","inactive","form","until","it","encounters","collagen","or","basement","membrane","or","activated","platelets","(","as","occurs","at","the","site","of","endothelial","injury",")","Factor","XII","then","undergoes","a","conformational","change","(","becoming","factor","XIIa",")",",","exposing","an","active","serine","center","that","can","subsequently","cleave","protein","substrates","and","activate","a","variety","of","mediator","systems",".","Factor","XII","is","a","participant","in","the","clotting","cascade","as","well","as","the","kinin","cascade","."),3996483). assertion_content_comment('tOboGo_FADBinding',s("Interacting","selectively","and","non-covalently","with","the","oxidized","form",",","FAD",",","of","flavin-adenine","dinucleotide",",","the","coenzyme","or","the","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes","."),4168687). assertion_content_comment('tOboGo_FADBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","FAD",",","the","oxidized","form","of","flavin-adenine","dinucleotide","."),4229056). assertion_content_comment('tOboGo_FADCarrierActivity',s("Catalysis","of","the","transfer","of","flavin","adenine","dinucleotide","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4219229). assertion_content_comment('tOboGo_FADCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","FAD",",","the","oxidized","form","of","flavin-adenine","dinucleotide","."),4333649). assertion_content_comment('tOboGo_FADDiphosphataseActivity',s("Catalysis","of","the","reaction",":","FAD","+","H2O","=","AMP","+","FMN","."),4376305). assertion_content_comment('tOboGo_FADH2Binding',s("Interacting","selectively","and","non-covalently","with","the","reduced","form",",","FADH2",",","of","flavin-adenine","dinucleotide",",","the","coenzyme","or","the","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes","."),4168737). assertion_content_comment('tOboGo_FADH2MetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","reduced","form","of","flavin","adenine","dinucleotide","."),4229028). assertion_content_comment('tOboGo_FADMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","FAD",",","the","oxidized","form","of","flavin","adenine","dinucleotide","."),4229048). assertion_content_comment('tOboGo_FADTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","flavin-adenine","dinucleotide","(","FAD",")","across","a","membrane","into",",","out","of","or","within","a","cell",",","or","between","cells",".","FAD","forms","the","coenzyme","of","the","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes",",","in","which","it","functions","as","an","electron","acceptor","by","being","reversibly","converted","to","its","reduced","form","."),4295305). assertion_content_comment('tOboGo_FADTransmembraneTransport',s("The","process","in","which","flavin-adenine","dinucleotide","(","FAD",")","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore",".","FAD","forms","the","coenzyme","of","the","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes",",","in","which","it","functions","as","an","electron","acceptor","by","being","reversibly","converted","to","its","reduced","form","."),4383071). assertion_content_comment('tOboGo_FADTransport',s("The","directed","movement","of","flavin-adenine","dinucleotide","(","FAD",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","FAD","forms","the","coenzyme","of","the","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes",",","in","which","it","functions","as","an","electron","acceptor","by","being","reversibly","converted","to","its","reduced","form","."),4294242). assertion_content_comment('tOboGo_FallopianTubeDevelopment',s("The","reproductive","developmental","process","whose","specific","outcome","is","the","progression","of","the","fallopian","tubes","over","time",",","from","their","formation","to","the","mature","structures","."),4159301). assertion_content_comment('tOboGo_FanconiAnaemiaNuclearComplex',s("A","protein","complex","composed","of","the","Fanconi","anaemia","(","FA",")","proteins","including","A",",","C",",","E",",","G","and","F","(","FANCA-F",")","Functions","in","the","activation","of","the","downstream","protein","FANCD2","by","monoubiquitylation",",","and","is","essential","for","protection","against","chromosome","breakage","."),4318592). assertion_content_comment('tOboGo_FarnesolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","sesquiterpenoid","alcohol","farnesol",",","3",",","7",",","11-trimethyl-2",",","6",",","10",",","dodecatrien-1-ol","."),4229679). assertion_content_comment('tOboGo_FarnesolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","sesquiterpenoid","alcohol","farnesol",",","3",",","7",",","11-trimethyl-2",",","6",",","10",",","dodecatrien-1-ol","."),4305075). assertion_content_comment('tOboGo_FarnesolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2-trans",",","6-trans-farnesol","+","NADP","(","+",")","=","2-trans",",","6-trans-farnesal","+","H","(","+",")","+","NADPH","."),4376334). assertion_content_comment('tOboGo_FarnesolKinaseActivity',s("Catalysis","of","the","reaction",":","farnesol","+","nucleoside","triphosphate","=","farnesyl","monophosphate","+","nucleoside","diphosphate","."),4192152). assertion_content_comment('tOboGo_FarnesolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","sesquiterpenoid","alcohol","farnesol",",","3",",","7",",","11-trimethyl-2",",","6",",","10",",","dodecatrien-1-ol","."),4229675). assertion_content_comment('tOboGo_FarnesylatedProteinBinding',s("Interacting","selectively","and","non-covalently","with","a","farnesylated","protein","."),4384149). assertion_content_comment('tOboGo_FarnesylDiphosphateBiosyntheticProcessMevalonatePathway',s("The","pathway","that","converts","acetate",",","in","the","form","of","acetyl-CoA",",","to","farnesyl","diphosphate","(","FPP",")","through","a","series","of","mevalonate","intermediates",".","Farnesyl","diphosphate","is","an","important","substrate","for","other","essential","pathways",",","such","as","biosynthesis","of","sterols","."),4032824). assertion_content_comment('tOboGo_FarnesylDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","farnesyl","diphosphate","."),4032817). assertion_content_comment('tOboGo_FarnesylDiphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","farnesyl","diphosphate","."),4298610). assertion_content_comment('tOboGo_FarnesylDiphosphateKinaseActivity',s("Catalysis","of","the","reaction",":","2-trans",",","6-trans-farnesyl","diphosphate","+","ATP","=","2-trans",",","6-trans-farnesyl","triphosphate","+","ADP","."),4376322). assertion_content_comment('tOboGo_FarnesylDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","farnesyl","diphosphate",",","an","intermediate","in","carotenoid",",","sesquiterpene",",","squalene","and","sterol","biosynthesis",",","as","well","as","a","substrate","in","protein","farnesylation","."),4032814). assertion_content_comment('tOboGo_FarnesyltranstransferaseActivity',s("Catalysis","of","the","reaction",":","2-trans",",","6-trans-farnesyl","diphosphate","+","isopentenyl","diphosphate","=","diphosphate","+","geranylgeranyl","diphosphate","."),4183558). assertion_content_comment('tOboGo_FasciaAdherens',s("A","cell-cell","junction","that","contains","the","transmembrane","protein","N-cadherin",",","which","interacts","with","identical","molecules","from","neighboring","cells","to","form","a","tight","mechanical","intercellular","link",";","forms","a","large","portion","of","the","intercalated","disc",",","the","structure","at","which","myofibrils","terminate","in","cardiomyocytes","."),4008109). assertion_content_comment('tOboGo_FasLBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fas","ligand","(","FasL","or","CD95L",")",",","an","antigen","originally","found","to","be","expressed","on","the","cell","surface","of","activated","human","T-lymphocytes","and","B-lymphocytes","and","a","variety","of","malignant","human","lymphoid","cell","lines","."),4086145). assertion_content_comment('tOboGo_FastEndocyticRecycling',s("The","directed","movement","of","membrane-bounded","vesicles","from","peripheral","endocytic","compartments","back","to","the","plasma","membrane","where","they","are","recycled","for","further","rounds","of","transport","."),4334919). assertion_content_comment('tOboGo_FastigialNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","fastigial","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042810). assertion_content_comment('tOboGo_FAT10ActivatingEnzymeActivity',s("Catalysis","of","the","activation","of","the","small","ubiquitin-related","modifier","FAT10",",","through","the","formation","of","an","ATP-dependent","high-energy","thiolester","bond","."),4245416). assertion_content_comment('tOboGo_FAT10HydrolaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4234205). assertion_content_comment('tOboGo_FAT10LigaseActivity',s("Catalysis","of","the","covalent","attachment","of","the","ubiquitin-like","protein","FAT10","to","other","proteins","."),4245286). assertion_content_comment('tOboGo_FatBodyDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","fat","body","over","time",",","from","its","formation","to","the","mature","structure",".","A","fat","body","is","an","insect","gland","dorsal","to","the","insect","gut",",","with","a","function","analogous","to","that","of","the","vertebrate","liver",".","It","is","a","storage","organ","for","fats",",","glycogen","and","protein","and","is","a","major","site","of","intermediary","metabolism","."),4018361). assertion_content_comment('tOboGo_FatBodyMetabolicProcessSensuInsecta',s("OBSOLETE",".","The","chemical","reactions","and","pathways","involving","the","fat","body",".","A","fat","body","is","a","fat-containing","cellular","structure","which","serves","as","an","energy","reserve",".","As","in",",","but","not","restricted","to",",","the","true","insects","(","Insecta",",","ncbi_taxonomy_id",":","50557",")"),4234873). assertion_content_comment('tOboGo_FatCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","adipocyte",",","an","animal","connective","tissue","cell","specialized","for","the","synthesis","and","storage","of","fat","."),4088307). assertion_content_comment('tOboGo_FatCellProliferation',s("The","multiplication","or","reproduction","of","fat","cells","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","A","fat","cell","is","an","animal","connective","tissue","cell","specialized","for","the","synthesis","and","storage","of","fat","."),4136615). assertion_content_comment('tOboGo_FatPadDevelopment',s("The","progression","of","a","fat","pad","from","its","initial","formation","to","its","mature","structure",".","A","fat","pad","is","an","accumulation","of","adipose","tissue","."),4160978). assertion_content_comment('tOboGo_FattyAcidAmideHydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","a","fatty","acid","amide","to","yield","a","fatty","acid","."),4269563). assertion_content_comment('tOboGo_FattyAcidBinding',s("Interacting","selectively","and","non-covalently","with","fatty","acids",",","aliphatic","monocarboxylic","acids","liberated","from","naturally","occurring","fats","and","oils","by","hydrolysis","."),4174488). assertion_content_comment('tOboGo_FattyAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","fatty","acid",",","any","of","the","aliphatic","monocarboxylic","acids","that","can","be","liberated","by","hydrolysis","from","naturally","occurring","fats","and","oils",".","Fatty","acids","are","predominantly","straight-chain","acids","of","4","to","24","carbon","atoms",",","which","may","be","saturated","or","unsaturated",";","branched","fatty","acids","and","hydroxy","fatty","acids","also","occur",",","and","very","long","chain","acids","of","over","30","carbons","are","found","in","waxes","."),4045767). assertion_content_comment('tOboGo_FattyAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","fatty","acid",",","any","of","the","aliphatic","monocarboxylic","acids","that","can","be","liberated","by","hydrolysis","from","naturally","occurring","fats","and","oils",".","Fatty","acids","are","predominantly","straight-chain","acids","of","4","to","24","carbon","atoms",",","which","may","be","saturated","or","unsaturated",";","branched","fatty","acids","and","hydroxy","fatty","acids","also","occur",",","and","very","long","chain","acids","of","over","30","carbons","are","found","in","waxes","."),4057921). assertion_content_comment('tOboGo_FattyAcidElongaseActivity',s("Catalysis","of","the","reaction",":","fatty","acid","(","C-16","or","longer",")","+","2-C","=","fatty","acid","(","C-16","or","longer","+","2-C",")"),4261831). assertion_content_comment('tOboGo_FattyAcidElongaseComplex',s("A","tetrameric","complex","of","four","different","subunits","which","catalyzes","the","elongation","of","fatty","acids","chains","2","carbon","units","at","a","time","in","the","synthesis","of","very","long","chain","fatty","acids","."),4021455). assertion_content_comment('tOboGo_FattyAcidElongationMonounsaturatedFattyAcid',s("Elongation","of","a","fatty","acid","chain","into","which","one","C-C","double","bond","has","been","introduced","."),4353780). assertion_content_comment('tOboGo_FattyAcidElongationPolyunsaturatedFattyAcid',s("Elongation","of","a","fatty","acid","chain","into","which","two","or","more","C-C","double","bonds","have","been","introduced","."),4353790). assertion_content_comment('tOboGo_FattyAcidElongationSaturatedFattyAcid',s("Elongation","of","a","saturated","fatty","acid","chain","."),4239480). assertion_content_comment('tOboGo_FattyAcidElongation',s("The","elongation","of","a","fatty","acid","chain","by","the","sequential","addition","of","two-carbon","units","."),4239478). assertion_content_comment('tOboGo_FattyAcidElongationUnsaturatedFattyAcid',s("Elongation","of","a","fatty","acid","chain","into","which","one","or","more","C-C","double","bonds","have","been","introduced","."),4239490). assertion_content_comment('tOboGo_FattyAcidHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","fatty","acid","within","an","organism","or","cell","."),4222061). assertion_content_comment('tOboGo_FattyAcidLigaseActivity',s("Catalysis","of","the","ligation","of","a","fatty","acid","to","an","acceptor",",","coupled","to","the","hydrolysis","of","ATP","."),4205651). assertion_content_comment('tOboGo_FattyAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fatty","acids",",","aliphatic","monocarboxylic","acids","liberated","from","naturally","occurring","fats","and","oils","by","hydrolysis","."),4044954). assertion_content_comment('tOboGo_FattyAcidOxidation',s("The","removal","of","one","or","more","electrons","from","a","fatty","acid",",","with","or","without","the","concomitant","removal","of","a","proton","or","protons",",","by","reaction","with","an","electron-accepting","substance",",","by","addition","of","oxygen","or","by","removal","of","hydrogen","."),4057946). assertion_content_comment('tOboGo_FattyAcidPeroxidaseActivity',s("Catalysis","of","the","reaction",":","2","H","(","2",")","O","(","2",")","+","H","(","+",")","+","palmitate","=","CO","(","2",")","+","3","H","(","2",")","O","+","pentadecanal","."),4376359). assertion_content_comment('tOboGo_FattyAcidSynthaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","n","malonyl-CoA","+","2n","NADPH","+","2n","H","+","=","long-chain","fatty","acid","+","n","+","1","CoA","+","n","CO2","+","2n","NADP","+"),4208459). assertion_content_comment('tOboGo_FattyAcidSynthaseComplex',s("A","multienzyme","complex","that","catalyses","the","synthesis","of","fatty","acids","from","acetyl","CoA","."),4221778). assertion_content_comment('tOboGo_FattyAcidTransporterActivity',s("Enables","the","directed","movement","of","fatty","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Fatty","acids","are","aliphatic","monocarboxylic","acids","liberated","from","naturally","occurring","fats","and","oils","by","hydrolysis","."),4170125). assertion_content_comment('tOboGo_FattyAcidTransport',s("The","directed","movement","of","fatty","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Fatty","acids","are","aliphatic","monocarboxylic","acids","liberated","from","naturally","occurring","fats","and","oils","by","hydrolysis","."),4024591). assertion_content_comment('tOboGo_FATZ1Binding',s("Interacting","selectively","and","non-covalently","with","FATZ","1",",","a","protein","of","FATZ","family","that","is","highly","expressed","in","skeletal","muscle","fast","fiber","."),4286109). assertion_content_comment('tOboGo_FATZ2Binding',s("Interacting","selectively","and","non-covalently","with","FATZ","2",",","a","protein","of","the","FATZ","family","that","is","highly","expressed","in","skeletal","muscle","fiber","fast","IIa","and","slow","I","and","in","cardiac","muscle","."),4286119). assertion_content_comment('tOboGo_FATZ3Binding',s("Interacting","selectively","and","non-covalently","with","FATZ","3",",","a","protein","of","the","FATZ","family","that","is","highly","expressed","in","skeletal","muscle","fast","fiber","."),4286129). assertion_content_comment('tOboGo_FATZBinding',s("Interacting","selectively","and","non-covalently","with","a","family","of","FATZ","proteins",",","filamin-",",","actinin-",",","and","telethonin-binding","proteins","of","the","Z-disc","of","striated","muscle",".","FATZ","proteins","are","located","in","the","Z-disc","of","the","sarcomere","and","are","involved","in","a","complex","network","of","interactions","with","other","Z-band","components","."),4286098). 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assertion_content_comment('tOboGo_FcReceptorMediatedStimulatorySignalingPathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","a","the","binding","of","the","Fc","portion","of","an","immunoglobulin","by","an","Fc","receptor","capable","of","activating","or","perpetuating","an","immune","response",".","The","Fc","portion","of","an","immunoglobulin","is","its","C-terminal","constant","region","."),4114998). assertion_content_comment('tOboGo_FearResponse',s("The","response","of","an","organism","to","a","perceived","external","threat","."),4316845). assertion_content_comment('tOboGo_FeedingBehavior',s("Behavior","associated","with","the","intake","of","food","."),3990996). assertion_content_comment('tOboGo_FemaleAnaliaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","analia","of","the","female","over","time",",","from","formation","to","the","mature","structure",".","The","analia","is","the","posterior-most","vertral","appendage","that","develops","from","the","genital","disc",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4105083). assertion_content_comment('tOboGo_FemaleAnaliaMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","analia","of","the","female","are","generated","and","organized",".","The","analia","is","the","posterior-most","vertral","appendage","that","develops","from","the","genital","disc",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4105104). assertion_content_comment('tOboGo_FemaleCourtshipBehavior',s("The","actions","or","reactions","of","a","female",",","for","the","purpose","of","attracting","a","sexual","partner","."),4014950). assertion_content_comment('tOboGo_FemaleGameteGeneration',s("Generation","of","the","female","gamete",";","specialised","haploid","cells","produced","by","meiosis","and","along","with","a","male","gamete","takes","part","in","sexual","reproduction","."),3980985). assertion_content_comment('tOboGo_FemaleGenitaliaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","female","genitalia","over","time",",","from","formation","to","the","mature","structure","."),4046681). assertion_content_comment('tOboGo_FemaleGenitaliaMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","female","genitalia","are","generated","and","organized","."),4105133). assertion_content_comment('tOboGo_FemaleGermCellNucleus',s("The","nucleus","of","the","female","germ","cell",",","a","reproductive","cell","in","females","."),4316772). assertion_content_comment('tOboGo_FemaleGermlineRingCanalFormationActinAssembly',s("Recruitment","and","organization","of","actin","filaments","in","female","germline","ring","canals","."),4020762). assertion_content_comment('tOboGo_FemaleGermlineRingCanalFormation',s("Assembly","of","the","intercellular","bridges","that","connect","the","germ-line","cells","of","a","female","cyst","."),4018837). assertion_content_comment('tOboGo_FemaleGermlineRingCanalInnerRim',s("A","proteinaceous","actin-rich","layer","of","the","insect","ovarian","ring","canal","that","forms","subcortically","to","the","outer","rim",".","The","electron","dense","inner","rim","accumulates","after","the","final","mitotic","division","of","each","germline","syncytia",",","and","contains","actin",",","a","phosphotyrosine","protein",",","and","a","number","of","cytoskeletal","proteins","."),4072046). assertion_content_comment('tOboGo_FemaleGermlineRingCanalOuterRim',s("An","electron","opaque","backbone","of","the","insect","ovarian","ring","canal","that","is","a","part","of","or","adjacent","to","the","plasma","membrane",".","The","outer","rim","is","established","as","the","cleavage","furrow","is","arrested",",","and","contains","F-actin",",","anillin",",","glycoproteins","and","at","least","one","a","protein","with","a","high","content","of","phosphorylated","tyrosine","residues","."),4072032). assertion_content_comment('tOboGo_FemaleGermlineRingCanal',s("An","intercellular","bridge","that","connects","the","germline","cells","of","a","female","cyst","."),4072019). assertion_content_comment('tOboGo_FemaleGermlineRingCanalStabilization',s("Maintenance","of","the","structural","integrity","of","the","ring","canals","connecting","the","female","germline","cyst","."),4020729). assertion_content_comment('tOboGo_FemaleGonadDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","female","gonad","over","time",",","from","its","formation","to","the","mature","structure","."),3981098). assertion_content_comment('tOboGo_FemaleMatingBehavior',s("The","specific","actions","or","reactions","of","a","female","organism","that","are","associated","with","reproduction","."),4014947). assertion_content_comment('tOboGo_FemaleMeiosisChromosomeSegregation',s("The","cell","cycle","process","in","which","genetic","material",",","in","the","form","of","chromosomes",",","is","organized","and","then","physically","separated","and","apportioned","to","two","or","more","sets","during","the","meiotic","cell","cycle","in","a","female","."),4034515). assertion_content_comment('tOboGo_FemaleMeiosisChromosomeSeparation',s("The","process","in","which","paired","chromosomes","are","physically","detached","from","each","other","during","female","meiosis","."),4286193). assertion_content_comment('tOboGo_FemaleMeiosisII',s("The","cell","cycle","process","in","which","the","second","meiotic","division","occurs","in","the","female","germline","."),4012992). assertion_content_comment('tOboGo_FemaleMeiosisI',s("The","cell","cycle","process","in","which","the","first","meiotic","division","occurs","in","the","female","germline","."),4011891). assertion_content_comment('tOboGo_FemaleMeiosis',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","nuclear","division","phase","of","a","meiotic","cell","cycle","in","the","female","germline","."),4011881). assertion_content_comment('tOboGo_FemaleMeiosisSisterChromatidCohesion',s("The","joining","of","the","sister","chromatids","of","a","replicated","chromosome","along","the","entire","length","of","the","chromosome","that","occurs","during","meiosis","in","a","female","."),4013137). assertion_content_comment('tOboGo_FemaleMeioticChromosomeMovementTowardsSpindlePole',s("The","directed","movement","of","chromosomes","in","the","center","of","the","spindle","towards","the","spindle","poles",",","mediated","by","the","shortening","of","microtubules","attached","to","the","chromosomes",",","during","female","meiosis","."),4034525). assertion_content_comment('tOboGo_FemalePigmentation',s("Establishment","of","a","pattern","of","pigment","in","females","."),4104346). assertion_content_comment('tOboGo_FemalePregnancy',s("The","set","of","physiological","processes","that","allow","an","embryo","or","foetus","to","develop","within","the","body","of","a","female","animal",".","It","covers","the","time","from","fertilization","of","a","female","ovum","by","a","male","spermatozoon","until","birth","."),4015320). assertion_content_comment('tOboGo_FemalePronucleusAssembly',s("Assembly","of","the","haploid","nucleus","of","the","unfertilized","egg","."),4072627). assertion_content_comment('tOboGo_FemalePronucleus',s("The","pronucleus","originating","from","the","ovum","that","is","being","fertilized","."),4384131). assertion_content_comment('tOboGo_FemaleSexDetermination',s("The","specification","of","female","sex","of","an","individual","organism","."),4049178). assertion_content_comment('tOboGo_FemaleSexDifferentiation',s("The","establishment","of","the","sex","of","a","female","organism","by","physical","differentiation","."),3981094). assertion_content_comment('tOboGo_FemaleSomaticSexDetermination',s("The","determination","of","sex","and","sexual","phenotypes","in","a","female","organism","'","s","soma","."),4237062). assertion_content_comment('tOboGo_FemaleUrethraDevelopment',s("The","progression","of","the","female","urethra","over","time","from","its","initial","formation","to","the","mature","structure",".","The","female","urethra","is","a","renal","system","organ","that","carries","urine","from","the","bladder","to","outside","the","body",",","exiting","above","the","vaginal","opening","."),4155952). assertion_content_comment('tOboGo_FeminizationOfHermaphroditeSoma',s("Promotion","of","female","sex","and","sexual","phenotypes","in","the","hermaphroditic","soma",".","An","example","of","this","is","found","in","Caenorhabditis","elegans","."),4306109). assertion_content_comment('tOboGo_Fermentation',s("The","anaerobic","enzymatic","conversion","of","organic","compounds",",","especially","carbohydrates",",","to","other","compounds",",","especially","to","ethyl","alcohol",",","yielding","energy","in","the","form","of","adenosine","triphosphate","(","ATP",")"),4010517). assertion_content_comment('tOboGo_FerredoxinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ferredoxin",",","any","simple",",","nonenzymatic","iron-sulfur","protein","that","is","characterized","by","having","equal","numbers","of","atoms","of","iron","and","labile","sulfur",".","Iron","and","sulfur","atoms","are","present","in","one","or","two","clusters","of","two","or","four","atoms","of","each","."),4317304). assertion_content_comment('tOboGo_FerredoxinHydrogenaseActivity',s("Catalysis","of","the","reaction",":","2","reduced","ferredoxin","+","2","H","+","=","2","oxidized","ferredoxin","+","H2","."),4248416). assertion_content_comment('tOboGo_FerredoxinHydrogenaseComplex',s("An","enzyme","complex","that","catalyzes","the","oxidation","of","reduced","ferredoxin",".","Hydrogenase","contains","iron-sulfur","clusters",",","and","some","contain","nickel",";","it","can","use","molecular","hydrogen","for","the","reduction","of","a","variety","of","substances","."),4260069). assertion_content_comment('tOboGo_FerredoxinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ferredoxin",",","any","simple",",","nonenzymatic","iron-sulfur","protein","that","is","characterized","by","having","equal","numbers","of","atoms","of","iron","and","labile","sulfur",".","Iron","and","sulfur","atoms","are","present","in","one","or","two","clusters","of","two","or","four","atoms","of","each","."),4228237). assertion_content_comment('tOboGo_Ferredoxin_ThioredoxinReductaseActivity',s("Catalysis","of","the","two-electron","reduction","of","the","disulfide","of","thioredoxins","with","electrons","from","ferredoxin","involving","a","4Fe-4S","cluster","and","an","adjacent","active-site","disulfide","."),4309447). assertion_content_comment('tOboGo_Ferredoxin_ThioredoxinReductaseComplex',s("A","protein","complex","that","possesses","ferredoxin",":","thioredoxin","reductase","activity","."),4309458). assertion_content_comment('tOboGo_FerricEnterobactin_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ferric","enterobactin","(","out",")","+","H","+","(","out",")","=","ferric","enterobactin","(","in",")","+","H","+","(","in",")"),4296156). assertion_content_comment('tOboGo_FerrichromeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","ferrichrome",".","Ferrichromes","are","any","of","a","group","of","growth-promoting","Fe","(","III",")","chelates","formed","by","various","genera","of","microfungi",".","They","are","homodetic","cyclic","hexapeptides","made","up","of","a","tripeptide","of","glycine","(","or","other","small","neutral","amino","acids",")","and","a","tripeptide","of","an","N","'","acyl-N4-hydroxy-L-ornithine","."),4318963). assertion_content_comment('tOboGo_FerrichromeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","ferrichrome",".","Ferrichromes","are","any","of","a","group","of","growth-promoting","Fe","(","III",")","chelates","formed","by","various","genera","of","microfungi",".","They","are","homodetic","cyclic","hexapeptides","made","up","of","a","tripeptide","of","glycine","(","or","other","small","neutral","amino","acids",")","and","a","tripeptide","of","an","N","'","acyl-N4-hydroxy-L-ornithine","."),4318950). assertion_content_comment('tOboGo_FerrichromeTransporterActivity',s("Enables","the","directed","movement","of","a","ferrichrome","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Ferrichromes","are","any","of","a","group","of","growth-promoting","Fe","(","III",")","chelates","formed","by","various","genera","of","microfungi",".","They","are","homodetic","cyclic","hexapeptides","made","up","of","a","tripeptide","of","glycine","(","or","other","small","neutral","amino","acids",")","and","a","tripeptide","of","an","N","'","acyl-N4-hydroxy-L-ornithine","."),4315809). assertion_content_comment('tOboGo_FerrichromeTransport',s("The","directed","movement","of","a","ferrichrome","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Ferrichromes","are","any","of","a","group","of","growth-promoting","Fe","(","III",")","chelates","formed","by","various","genera","of","microfungi",".","They","are","homodetic","cyclic","hexapeptides","made","up","of","a","tripeptide","of","glycine","(","or","other","small","neutral","amino","acids",")","and","a","tripeptide","of","an","N","'","acyl-N4-hydroxy-L-ornithine","."),4315799). assertion_content_comment('tOboGo_FerricIronBinding',s("Interacting","selectively","and","non-covalently","with","ferric","iron",",","Fe","(","III",")"),4246144). assertion_content_comment('tOboGo_FerricIronImport',s("The","directed","movement","of","ferric","iron","(","Fe","(","III",")","or","Fe3","+",")","ions","into","a","cell","or","organelle","."),4338204). assertion_content_comment('tOboGo_FerricIronTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","ferric","iron","(","Fe","(","III",")","or","Fe3","+",")","ions","from","one","side","of","a","membrane","to","the","other","."),4289390). assertion_content_comment('tOboGo_FerricIronTransport',s("The","directed","movement","of","ferric","iron","(","Fe","(","III",")","or","Fe3","+",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290027). assertion_content_comment('tOboGo_FerricrocinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ferricrocin",",","a","cyclic","hexapeptide","siderophore","with","the","structure","Gly-Ser-Gly-","(","N5-acetyl-N5-hydroxyornithine",")","3","."),4319001). assertion_content_comment('tOboGo_FerricrocinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ferricrocin",",","a","cyclic","hexapeptide","siderophore","with","the","structure","Gly-Ser-Gly-","(","N5-acetyl-N5-hydroxyornithine",")","3","."),4318998). assertion_content_comment('tOboGo_FerricTriacetylfusarinineC_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ferric","triacetylfusarinine","C","(","out",")","+","H","+","(","out",")","=","ferric","triacetylfusarinine","C","(","in",")","+","H","+","(","in",")"),4296168). assertion_content_comment('tOboGo_FerricTriacetylfusarinineCTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","ferric","triacetylfusarinine","C","from","one","side","of","a","membrane","to","the","other","."),4289392). assertion_content_comment('tOboGo_FerricTriacetylfusarinineCTransport',s("The","directed","movement","of","ferric","triacetylfusarinine","C","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290053). assertion_content_comment('tOboGo_FerritinComplex',s("A","protein","complex","that","binds","iron","and","acts","as","a","major","iron","storage","system",".","Intracellular","and","extracellular","ferritin","complexes","have","different","ratios","of","two","types","of","ferritin","monomer",",","the","L","(","light",")","chain","and","H","(","heavy",")","chain","."),4174100). assertion_content_comment('tOboGo_FerritinReceptorActivity',s("Combining","with","ferritin",",","an","iron-storing","protein","complex",",","to","initiate","a","change","in","cell","activity","."),4174112). assertion_content_comment('tOboGo_FerrochelataseActivity',s("Catalysis","of","the","reaction",":","protoheme","=","Fe","(","2","+",")","+","protoporphyrin","IX","."),4208642). assertion_content_comment('tOboGo_FerrousIronBinding',s("Interacting","selectively","and","non-covalently","with","ferrous","iron",",","Fe","(","II",")"),4246166). assertion_content_comment('tOboGo_FerrousIronImport',s("The","directed","movement","of","ferrous","iron","(","Fe","(","II",")","or","Fe2","+",")","ions","across","a","membrane","into","a","cell","or","organelle","."),4177001). assertion_content_comment('tOboGo_FerrousIronTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","ferrous","iron","(","Fe","(","II",")","or","Fe2","+",")","ions","from","one","side","of","a","membrane","to","the","other","."),4290550). assertion_content_comment('tOboGo_FerrousIronTransport',s("The","directed","movement","of","ferrous","iron","(","Fe","(","II",")","or","Fe2","+",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4176997). assertion_content_comment('tOboGo_FerrousIronUptakeTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Fe2","+","(","out",")","+","energy","=","Fe2","+","(","in",")"),4290552). assertion_content_comment('tOboGo_FerroxidaseActivity',s("Catalysis","of","the","reaction",":","4","Fe2","+","+","4","H","+","+","O2","=","4","Fe3","+","+","2","H2O","."),4208569). assertion_content_comment('tOboGo_FertilizationEnvelope',s("A","structure","that","lies","outside","the","plasma","membrane","and","surrounds","the","egg",".","The","fertilization","envelope","forms","from","the","vitelline","membrane","after","fertilization","as","a","result","of","cortical","granule","release","."),4160222). assertion_content_comment('tOboGo_FertilizationExchangeOfChromosomalProteins',s("Replacement","of","sperm-specific","chromosomal","proteins","with","somatic","histones",",","to","allow","the","paternal","genome","to","acquire","a","nucleosomal","chromatin","organization","compatible","with","nuclear","activity","."),4072708). assertion_content_comment('tOboGo_Fertilization',s("The","union","of","gametes","of","opposite","sexes","during","the","process","of","sexual","reproduction","to","form","a","zygote",".","It","involves","the","fusion","of","the","gametic","nuclei","(","karyogamy",")","and","cytoplasm","(","plasmogamy",")"),3990176). assertion_content_comment('tOboGo_FerulateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ferulate",",","(","2E",")","-3-","(","4-hydroxy-3-methoxyphenyl",")","prop-2-enoate","."),4339750). assertion_content_comment('tOboGo_FerulateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ferulate",",","(","2E",")","-3-","(","4-hydroxy-3-methoxyphenyl",")","prop-2-enoate","."),4339747). assertion_content_comment('tOboGo_FeruloylEsteraseActivity',s("Catalysis","of","the","reaction",":","feruloyl-polysaccharide","+","H2O","=","ferulate","+","polysaccharide","."),4308322). assertion_content_comment('tOboGo_FetalProcessInvolvedInParturition',s("A","reproductive","process","occurring","in","the","embryo","that","results","in","birth","."),4108104). assertion_content_comment('tOboGo_FeverGeneration',s("The","heat","generation","process","that","results","in","a","rise","in","body","temperature","above","the","normal",",","often","as","a","response","to","infection","."),4059948). assertion_content_comment('tOboGo_FFATMotifBinding',s("Interacting","selectively","and","non-covalently","with","the","FFAT","motif",",","a","short","motif","containing","diphenylalanine","in","an","acidic","tract","that","targets","proteins","to","the","cytosolic","surface","of","the","ER","and","to","the","nuclear","membrane","by","binding","directly","to","members","of","the","VAP","(","VAMP-associated","protein",")","protein","family","."),4347888). assertion_content_comment('tOboGo_FH1DomainBinding',s("Interacting","selectively","and","non-covalently","with","a","FH1","domain","of","a","protein",",","a","proline-rich","domain",",","usually","located","in","front","of","a","FH2","domain","."),4269743). assertion_content_comment('tOboGo_FHADomainBinding',s("Interacting","selectively","and","non-covalently","with","a","FHA","domain","of","a","protein",".","The","FHA","domain","is","a","phosphopeptide","recognition","domain","found","in","many","regulatory","proteins",",","and","consists","of","approximately","80-100","amino","acid","residues","folded","into","an","11-stranded","beta","sandwich","."),4177720). assertion_content_comment('tOboGo_FHFComplex',s("A","protein","complex","that","is","composed","of","AKTIP/FTS",",","FAM160A2/p107FHIP",",","and","one","or","more","members","of","the","Hook","family","of","proteins",",","HOOK1",",","HOOK2",",","and","HOOK3",".","The","complex","is","thought","to","promote","vesicle","trafficking","and/or","fusion",",","and","associates","with","the","homotypic","vesicular","sorting","complex","(","the","HOPS","complex",")"),4177537). assertion_content_comment('tOboGo_FibrillarCenter',s("A","structure","found","most","metazoan","nucleoli",",","but","not","usually","found","in","lower","eukaryotes",";","surrounded","by","the","dense","fibrillar","component",";","the","zone","of","transcription","from","multiple","copies","of","the","pre-rRNA","genes","is","in","the","border","region","between","these","two","structures","."),4384058). assertion_content_comment('tOboGo_FibrillarCollagen',s("Any","collagen","polymer","in","which","collagen","triple","helices","associate","to","form","fibrils","."),4218092). assertion_content_comment('tOboGo_Fibrillin',s("OBSOLETE",".","Large","glycoprotein","that","is","a","calcium","binding","component","of","connective","tissue","microfibrils","containing","34","six-cysteine","(","EGF-like",")","repeats","and","five","eight-cysteine","(","TGFbeta-1","binding","protein-like",")","repeats",".","Defects","associated","with","Marfan","syndrome","."),4361553). assertion_content_comment('tOboGo_FibrilOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","fibrils",",","extracellular","matrix","material","consisting","of","polysaccharides","and","protein","."),4318624). assertion_content_comment('tOboGo_Fibril',s("Extracellular","matrix","material","consisting","of","polysaccharides","and","protein","."),4023071). assertion_content_comment('tOboGo_FibrinogenAlphaChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4221361). assertion_content_comment('tOboGo_FibrinogenBetaChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4221373). assertion_content_comment('tOboGo_FibrinogenBinding',s("Interacting","selectively","and","non-covalently","with","fibrinogen",",","a","highly","soluble","hexameric","glycoprotein","complex","that","is","found","in","blood","plasma","and","is","converted","to","fibrin","by","thrombin","in","the","coagulation","cascade","."),4180680). assertion_content_comment('tOboGo_FibrinogenComplex',s("A","highly","soluble",",","elongated","protein","complex","found","in","blood","plasma","and","involved","in","clot","formation",".","It","is","converted","into","fibrin","monomer","by","the","action","of","thrombin",".","In","the","mouse",",","fibrinogen","is","a","hexamer",",","46","nm","long","and","9","nm","maximal","diameter",",","containing","two","sets","of","nonidentical","chains","(","alpha",",","beta",",","and","gamma",")","linked","together","by","disulfide","bonds","."),4007115). assertion_content_comment('tOboGo_FibrinogenGammaChain',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4221385). assertion_content_comment('tOboGo_Fibrinogen',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4247441). assertion_content_comment('tOboGo_Fibrinolysis',s("An","ongoing","process","that","solubilizes","fibrin",",","chiefly","by","the","proteolytic","action","of","plasmin",",","resulting","in","the","removal","of","small","blood","clots","."),4120230). assertion_content_comment('tOboGo_FibroblastActivation',s("A","change","in","the","morphology","or","behavior","of","a","fibroblast","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand","."),4145869). assertion_content_comment('tOboGo_FibroblastApoptosis',s("Apoptosis","of","a","fibroblast",",","a","connective","tissue","cell","which","secretes","an","extracellular","matrix","rich","in","collagen","and","other","macromolecules","."),4140215). assertion_content_comment('tOboGo_FibroblastGrowthFactor1Binding',s("Interacting","selectively","and","non-covalently","with","fibroblast","growth","factor","1","."),4332582). assertion_content_comment('tOboGo_FibroblastGrowthFactor2Binding',s("Interacting","selectively","and","non-covalently","with","fibroblast","growth","factor","2","."),4332592). assertion_content_comment('tOboGo_FibroblastGrowthFactor3Binding',s("Interacting","selectively","and","non-covalently","with","fibroblast","growth","factor","3","."),4332602). assertion_content_comment('tOboGo_FibroblastGrowthFactor4Binding',s("Interacting","selectively","and","non-covalently","with","fibroblast","growth","factor","4","."),4332632). assertion_content_comment('tOboGo_FibroblastGrowthFactor5Binding',s("Interacting","selectively","and","non-covalently","with","fibroblast","growth","factor","5","."),4332622). assertion_content_comment('tOboGo_FibroblastGrowthFactor6Binding',s("Interacting","selectively","and","non-covalently","with","fibroblast","growth","factor","6","."),4332612). assertion_content_comment('tOboGo_FibroblastGrowthFactorBinding',s("Interacting","selectively","and","non-covalently","with","fibroblast","growth","factor","."),4257982). assertion_content_comment('tOboGo_FibroblastGrowthFactorProduction',s("The","appearance","of","a","fibroblast","growth","factor","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4151774). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorActivity',s("Combining","with","fibroblast","growth","factor","to","initiate","a","change","in","cell","activity","."),4213828). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorAntagonistActivity',s("Interacts","with","the","fibroblast","growth","factor","receptor","to","reduce","the","action","of","another","ligand",",","the","agonist","."),4309544). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","fibroblast","growth","factor","receptor","(","FGFR",")"),4214276). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInForebrainNeuroblastDivision',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","that","contributes","to","the","self","renewal","of","neuroblasts","in","the","forebrain","."),4047425). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInForebrainNeuronFateCommitment',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","that","contributes","to","the","commitment","of","a","neuroblast","to","a","neuronal","fate",".","The","neuron","will","reside","in","the","forebrain","."),4047720). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInHeartDevelopment',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","and","contributing","to","the","progression","of","the","heart","over","time","."),4001322). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInHeartInduction',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","that","contributes","to","heart","induction","."),4003526). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInHemopoiesis',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands",",","which","contributes","to","hemopoiesis","."),4082053). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInLungInduction',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor-type","receptor","binding","to","one","of","its","physiological","ligands","resulting","in","the","formation","of","the","lung","bud","along","the","lateral-esophageal","sulcus","."),4117614). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInMammaryGlandSpecification',s("The","series","of","molecular","signals","initiated","by","binding","of","a","fibroblast","growth","factor","to","its","receptor","on","the","surface","of","al","cell","in","the","epidermis","resulting","in","the","formation","of","the","mammary","line",".","The","mammary","line","is","a","ridge","of","epidermal","cells","that","will","form","the","mammary","placodes","."),4116983). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInNegativeRegulationOfApoptosisInBoneMarrow',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands",",","which","stops",",","prevents",",","or","reduces","the","frequency",",","rate","or","extent","of","the","occurrence","or","rate","of","cell","death","by","apoptosis","in","the","bone","marrow","."),4082041). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInNeuralPlateAnteriorPosteriorPatternFormation',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","contributing","to","the","anterior/posterior","pattern","of","the","neural","plate","."),4111279). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInOrbitofrontalCortexDevelopment',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor-type","receptor","binding","to","one","of","its","physiological","ligands",",","which","contributes","to","the","progression","of","the","orbitofrontal","cortex","over","time","from","its","initial","formation","until","its","mature","state","."),4082113). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInPositiveRegulationOfCellProliferationInBoneMarrow',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands",",","which","activates","or","increases","the","frequency",",","rate","or","extent","of","cell","proliferation","in","the","bone","marrow","."),4082101). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInRegulationOfSecondaryHeartFieldCardioblastCellProliferation',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","contributing","to","the","modulation","of","the","frequency",",","rate","or","extent","of","cardioblast","proliferation",".","A","cardioblast","is","a","cardiac","precursor","cell",".","It","is","a","cell","that","has","been","committed","to","a","cardiac","fate",",","but","will","undergo","more","cell","division","rather","than","terminally","differentiating","."),4001326). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInSomitogenesis',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","that","contributes","to","somitogenesis","."),4151491). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathwayInvolvedInSpinalCordAnteriorPosteriorPatternFormation',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","that","results","in","the","spatial","identity","of","regions","along","the","anterior-posterior","axis","of","the","spinal","cord","."),4048607). assertion_content_comment('tOboGo_FibroblastGrowthFactorReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","fibroblast","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","."),4001315). assertion_content_comment('tOboGo_FibroblastMigration',s("Cell","migration","that","is","accomplished","by","extension","and","retraction","of","a","fibroblast","pseudopodium",".","A","fibroblast","is","a","connective","tissue","cell","which","secretes","an","extracellular","matrix","rich","in","collagen","and","other","macromolecules","."),4024943). assertion_content_comment('tOboGo_FibroblastProliferationInvolvedInHeartMorphogenesis',s("The","multiplication","or","reproduction","of","fibroblasts",",","resulting","in","the","expansion","of","a","fibroblast","population","that","contributes","to","the","shaping","of","the","heart","."),4261439). assertion_content_comment('tOboGo_FibroblastProliferation',s("The","multiplication","or","reproduction","of","fibroblast","cells",",","resulting","in","the","expansion","of","the","fibroblast","population","."),4103490). assertion_content_comment('tOboGo_FibrolaseActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","14-Ala-Leu-15","in","insulin","B","chain","and","cleavage","of","413-Lys-Leu-414","in","alpha","chain","of","fibrinogen","."),4306305). assertion_content_comment('tOboGo_FibronectinBinding',s("Interacting","selectively","and","non-covalently","with","a","fibronectin",",","a","group","of","related","adhesive","glycoproteins","of","high","molecular","weight","found","on","the","surface","of","animal","cells",",","connective","tissue","matrices",",","and","in","extracellular","fluids","."),4384158). assertion_content_comment('tOboGo_FilamentousActin',s("A","two-stranded","helical","polymer","of","the","protein","actin","."),4057579). assertion_content_comment('tOboGo_FilamentousGrowthOfAMulticellularOrganism',s("The","process","in","which","a","multicellular","organism","grows","in","a","threadlike",",","filamentous","shape","."),4288333). assertion_content_comment('tOboGo_FilamentousGrowthOfAPopulationOfUnicellularOrganisms',s("The","process","in","which","a","group","of","unicellular","organisms","grow","in","a","threadlike",",","filamentous","shape","."),4132643). assertion_content_comment('tOboGo_FilamentousGrowthOfAUnicellularOrganism',s("The","process","in","which","a","unicellular","organism","grows","in","a","threadlike",",","filamentous","shape","."),4288323). assertion_content_comment('tOboGo_FilamentousGrowth',s("The","process","in","which","a","multicellular","organism",",","a","unicellular","organism","or","a","group","of","unicellular","organisms","grow","in","a","threadlike",",","filamentous","shape","."),3980202). assertion_content_comment('tOboGo_FilaminBinding',s("Interacting","selectively","and","non-covalently","with","a","filamin",",","any","member","of","a","family","of","high","molecular","mass","cytoskeletal","proteins","that","crosslink","actin","filaments","to","form","networks","and","stress","fibers",".","Filamins","contain","an","amino-terminal","alpha-actinin-like","actin","binding","domain",",","which","is","followed","by","a","rod-domain","composed","of","4","to","24","100-residue","repetitive","segments","including","a","carboxy-terminal","dimerization","domain","."),4319105). assertion_content_comment('tOboGo_FiliformApparatus',s("A","complex","of","cell","wall","invaginations","in","a","synergid","cell",",","similar","to","those","in","transfer","cells","."),4326550). assertion_content_comment('tOboGo_FilopodiumAssembly',s("The","assembly","of","a","filopodium",",","a","very","long","microspike","extended","by","the","leading","edge","of","a","motile","cell","such","as","a","crawling","fibroblast","or","amoeba",",","or","by","the","growth","cone","of","a","developing","nerve","cell","axon","."),4118959). assertion_content_comment('tOboGo_FilopodiumMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","filopodium","."),4060663). assertion_content_comment('tOboGo_Filopodium',s("Thin",",","stiff","protrusion","extended","by","the","leading","edge","of","a","motile","cell","such","as","a","crawling","fibroblast","or","amoeba",",","or","an","axonal","growth","cone",";","usually","approximately","0.1","um","wide",",","5-10","um","long",",","can","be","up","to","50","um","long","in","axon","growth","cones",";","contains","a","loose","bundle","of","about","20","actin","filaments","oriented","with","their","plus","ends","pointing","outward","."),4055601). assertion_content_comment('tOboGo_FilopodiumTip',s("The","end","of","a","filopodium","distal","to","the","body","of","the","cell","."),4055612). assertion_content_comment('tOboGo_FimbrialUsherPorinActivity',s("A","porin","that","acts","in","the","assembly","of","fimbria","together","with","fimbrial","chaperone","."),4292446). assertion_content_comment('tOboGo_Fimbrin',s("OBSOLETE",".","A","class","of","proteins","that","are","the","subunit","components","of","fimbria","."),4258647). assertion_content_comment('tOboGo_FinDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","fin","over","time",",","from","its","formation","to","the","mature","structure","."),4063071). assertion_content_comment('tOboGo_FinMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","fin","are","generated","and","organized","."),4063081). assertion_content_comment('tOboGo_FinRegeneration',s("The","regrowth","of","fin","tissue","following","its","loss","or","destruction","."),4318860). assertion_content_comment('tOboGo_FirstCellCyclePseudocleavage',s("A","process","that","occurs","during","the","first","cell","cycle","in","an","embryo",",","in","which","anterior","cortical","contractions","culminate","in","a","single","partial","constriction","of","the","embryo","called","the","pseudocleavage","furrow",".","An","example","of","this","process","is","found","in","nematode","worms","."),4307796). assertion_content_comment('tOboGo_FirstSpliceosomalTransesterificationActivity',s("Catalysis","of","the","first","transesterification","reaction","of","spliceosomal","mRNA","splicing",".","The","intron","branch","site","adenosine","is","the","nucleophile","attacking","the","5","'","splice","site",",","resulting","in","cleavage","at","this","position",".","In","cis","splicing",",","this","is","the","step","that","forms","a","lariat","structure","of","the","intron","RNA",",","while","it","is","still","joined","to","the","3","'","exon","."),4362919). assertion_content_comment('tOboGo_FishTrapBristleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","fish","trap","bristle","over","time",",","from","its","formation","to","the","mature","structure","."),4107262). assertion_content_comment('tOboGo_FishTrapBristleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","fish","trap","bristle","are","generated","and","organized","."),4107383). assertion_content_comment('tOboGo_FK506Binding',s("Interacting","selectively","and","non-covalently","with","the","immunosuppressant","FK506","."),4218745). assertion_content_comment('tOboGo_FlagellarAxonemeAssembly',s("The","assembly","of","the","bundle","of","microtubules","and","associated","proteins","that","forms","the","core","of","flagellar","in","eukaryotic","cells","and","is","responsible","for","their","movements","."),4016827). assertion_content_comment('tOboGo_FlagellarAxoneme',s("The","bundle","of","microtubules","and","associated","proteins","that","forms","the","core","of","flagellar","in","eukaryotic","cells","and","is","responsible","for","their","movements","."),4073086). assertion_content_comment('tOboGo_FlagellarCellMotility',s("Cell","motility","due","to","the","motion","of","one","or","more","flagella","."),4137778). assertion_content_comment('tOboGo_FlagellarFibrousSheath',s("A","cytoskeletal","structure","surrounding","the","axoneme","and","outer","dense","fibers","of","the","sperm","flagellum",".","Consists","of","two","longitudinal","columns","connected","by","closely","arrayed","semicircular","ribs","that","assemble","from","distal","to","proximal","throughout","spermiogenesis",".","The","fibrous","sheath","probably","influences","the","degree","of","flexibility",",","plane","of","flagellar","motion",",","and","the","shape","of","the","flagellar","beat","."),4380304). assertion_content_comment('tOboGo_FlagellarMembrane',s("The","portion","of","the","plasma","membrane","surrounding","the","flagellum","."),4041983). assertion_content_comment('tOboGo_FlagellarPocketMembrane',s("That","part","of","the","plasma","membrane","found","in","the","flagellar","pocket","."),4041986). assertion_content_comment('tOboGo_FlagellarPocket',s("Invagination","of","the","plasma","membrane","from","which","a","flagellum","protrudes","."),4041953). assertion_content_comment('tOboGo_FlagellumAssembly',s("The","assembly","of","a","flagellum",".","In","bacteria",",","this","is","a","whiplike","motility","appendage","present","on","the","surface","of","some","species",";","in","eukaryotes",",","flagella","are","threadlike","protoplasmic","extensions","used","to","propel","flagellates","and","sperm",".","Flagella","are","composed","of","flagellin","and","have","the","same","basic","structure","as","cilia","but","are","longer","in","proportion","to","the","cell","and","present","in","much","smaller","numbers","."),4016822). assertion_content_comment('tOboGo_FlagellumOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","flagellum",",","a","long","thin","projection","from","a","cell",",","used","in","movement","."),4016818). assertion_content_comment('tOboGo_FlagellumPart',s("Any","constituent","part","of","a","flagellum",",","a","long","whiplike","or","feathery","structure","borne","either","singly","or","in","groups","by","the","motile","cells","of","many","bacteria","and","unicellular","eukaryotes","and","by","the","motile","male","gametes","of","many","eukaryotic","organisms",",","which","propel","the","cell","through","a","liquid","medium","."),4023528). assertion_content_comment('tOboGo_Flagellum',s("Long","whiplike","or","feathery","structures","borne","either","singly","or","in","groups","by","the","motile","cells","of","many","bacteria","and","unicellular","eukaryotes","and","by","the","motile","male","gametes","of","many","eukaryotic","organisms",",","which","propel","the","cell","through","a","liquid","medium","."),4023526). assertion_content_comment('tOboGo_FlapEndonucleaseActivity',s("Catalysis","of","the","cleavage","of","a","flap","structure","in","DNA",",","but","not","other","DNA","structures",";","processes","the","ends","of","Okazaki","fragments","in","lagging","strand","DNA","synthesis","."),4267622). assertion_content_comment('tOboGo_FlavinAdenineDinucleotideBinding',s("Interacting","selectively","and","non-covalently","with","FAD",",","flavin-adenine","dinucleotide",",","the","coenzyme","or","the","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes",",","in","either","the","oxidized","form",",","FAD",",","or","the","reduced","form",",","FADH2","."),4168683). assertion_content_comment('tOboGo_FlavinAdenineDinucleotideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","flavin","adenine","dinucleotide",",","which","acts","as","a","coenzyme","or","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes","."),4158939). assertion_content_comment('tOboGo_FlavinAdenineDinucleotideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","flavin","adenine","dinucleotide",",","which","acts","as","a","coenzyme","or","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes","."),4158975). assertion_content_comment('tOboGo_FlavinAdenineDinucleotideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","flavin","adenine","dinucleotide",",","which","acts","as","a","coenzyme","or","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes","."),4158934). assertion_content_comment('tOboGo_FlavinReductaseActivity',s("Catalysis","of","the","reaction",":","reduced","riboflavin","+","NADP","+","=","riboflavin","+","NADPH","+","H","+"),4305706). assertion_content_comment('tOboGo_Flavodoxin',s("OBSOLETE",".","A","group","of","small","electron","carriers",",","characteristic","of","anaerobic","bacteria",",","photosynthetic","bacteria",",","cyanobacteria","and","eukaryotic","algae",".","Contain","flavin","mononucleotide","."),4259159). assertion_content_comment('tOboGo_FlavoneApiosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-apiose","+","7-O-beta-D-glucosyl-5",",","7",",","4","'","-trihydroxyflavone","=","UDP","+","7-O-","(","beta-D-apiofuranosyl-1",",","2-beta-D-glucosyl",")","-5",",","7",",","4","'","-trihydroxyflavone","."),4375765). assertion_content_comment('tOboGo_FlavoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","flavones",",","a","class","of","pigmented","plant","compounds","based","on","2-phenyl-4H-1-benzopyran-4-one","(","2-phenylchromone",")"),4283883). assertion_content_comment('tOboGo_FlavoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","flavones",",","a","class","of","pigmented","plant","compounds","based","on","2-phenyl-4H-1-benzopyran-4-one","(","2-phenylchromone",")"),4283818). assertion_content_comment('tOboGo_FlavoneSynthaseActivity',s("Catalysis","of","the","reaction",":","a","flavanone","+","2-oxoglutarate","+","O2","=","a","flavone","+","succinate","+","CO2","+","H2O","."),4342678). assertion_content_comment('tOboGo_FlavonoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","flavonoids",",","a","group","of","phenolic","derivatives","containing","a","flavan","skeleton","."),4033116). assertion_content_comment('tOboGo_FlavonoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","flavonoids",",","a","group","of","phenolic","derivatives","containing","a","flavan","skeleton","."),4352967). assertion_content_comment('tOboGo_FlavonoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","flavonoids",",","a","group","of","water-soluble","phenolic","derivatives","containing","a","flavan","skeleton","including","flavones",",","flavonols","and","flavanoids",",","and","anthocyanins","."),4026403). assertion_content_comment('tOboGo_FlavonoidPhytoalexinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","flavonoid","phytoalexins",",","a","group","of","water-soluble","phenolic","derivatives","containing","a","flavan","skeleton",",","which","possess","antibiotic","activity","and","are","produced","by","plant","tissues","in","response","to","infection","."),4260580). assertion_content_comment('tOboGo_FlavonoidPhytoalexinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","flavonoid","phytoalexins",",","a","group","of","water-soluble","phenolic","derivatives","containing","a","flavan","skeleton",",","which","possess","antibiotic","activity","and","are","produced","by","plant","tissues","in","response","to","infection","."),4352974). assertion_content_comment('tOboGo_FlavonoidPhytoalexinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","flavonoid","phytoalexins",",","a","group","of","water-soluble","phenolic","derivatives","containing","a","flavan","skeleton",",","which","possess","antibiotic","activity","and","are","produced","by","plant","tissues","in","response","to","infection","."),4260576). assertion_content_comment('tOboGo_FlavonolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","flavonols",",","a","member","of","a","class","of","vascular","pigments","formed","by","consecutive","oxidative","processes","from","the","flavonoid","intermediates","flavanones","and","dihydroflavonols",".","Flavonols","are","the","most","widespread","of","the","flavonoids","and","have","a","wide","array","of","physiological","activities","."),4283900). assertion_content_comment('tOboGo_FlavonolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","flavonols",",","a","member","of","a","class","of","vascular","pigments","formed","by","consecutive","oxidative","processes","from","the","flavonoid","intermediates","flavanones","and","dihydroflavonols",".","Flavonols","are","the","most","widespread","of","the","flavonoids","and","have","a","wide","array","of","physiological","activities","."),4283897). assertion_content_comment('tOboGo_FlavonolSynthaseActivity',s("Catalysis","of","the","reaction",":","a","dihydroflavonol","+","2-oxoglurate","+","O2","=","a","flavonol","+","succinate","+","CO2","+","H2O","."),4299636). assertion_content_comment('tOboGo_FlightBehavior',s("The","response","to","external","or","internal","stimuli","that","results","in","the","locomotory","process","of","flight",".","Flight","is","the","self-propelled","movement","of","an","organism","through","the","air","."),4115070). 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assertion_content_comment('tOboGo_FloorPlateDevelopment',s("The","progression","of","the","floor","plate","over","time","from","its","initial","formation","until","its","mature","state","."),4041550). assertion_content_comment('tOboGo_FloorPlateFormation',s("The","formation","of","a","ventral","region","of","glial","cells","in","the","neural","tube","that","provides","inductive","signals","for","the","specification","of","neuronal","cell","types",".","The","floor","plate","is","evident","at","the","ventral","midline","by","the","neural","fold","stage","."),4041564). assertion_content_comment('tOboGo_FloorPlateMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","floor","plate","is","generated","and","organized","."),4041552). assertion_content_comment('tOboGo_FloralMeristemDeterminacy',s("The","process","in","which","a","floral","meristem","becomes","determinate","(","i.e",".","ceases","to","produce","lateral","organs","and","may","or","may","not","terminally","differentiate",")"),4028387). assertion_content_comment('tOboGo_FloralMeristemGrowth',s("The","increase","in","size","or","mass","of","a","floral","meristem",",","a","population","of","undifferentiated","cells","in","a","plant","that","gives","rise","to","a","flower","."),4029482). assertion_content_comment('tOboGo_FloralOrganAbscission',s("The","controlled","shedding","of","floral","organs","."),4032109). assertion_content_comment('tOboGo_FloralOrganDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","floral","organ","over","time",",","from","its","formation","to","the","mature","structure","."),4021399). assertion_content_comment('tOboGo_FloralOrganFormation',s("The","process","that","gives","rise","to","floral","organs",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4032018). assertion_content_comment('tOboGo_FloralOrganMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","floral","organ","are","generated","and","organized","."),4028869). assertion_content_comment('tOboGo_FloralOrganStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","floral","organs",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4101888). assertion_content_comment('tOboGo_FloralWhorlDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","floral","whorl","over","time",",","from","its","formation","to","the","mature","structure",".","A","floral","whorl","is","a","circular","arrangement","of","parts","of","a","flower","arising","from","a","stem","of","a","plant","."),4021419). assertion_content_comment('tOboGo_FloralWhorlFormation',s("The","process","that","gives","rise","to","the","floral","whorl",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4101930). assertion_content_comment('tOboGo_FloralWhorlMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","floral","whorl","are","generated","and","organized","."),4101918). assertion_content_comment('tOboGo_FloralWhorlStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","floral","whorl",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4103240). assertion_content_comment('tOboGo_FlotillinComplex',s("A","protein","complex","that","contains","flotillin-1","and","flotillin-2",",","and","may","contain","associated","proteins",".","Flotillins","associate","into","membrane","microdomains","resembling","caveolae","."),4040751). assertion_content_comment('tOboGo_FlowerCalyxDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","flower","calyx","over","time",",","from","its","formation","to","the","mature","structure","."),4032358). assertion_content_comment('tOboGo_FlowerDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","flower","over","time",",","from","its","formation","to","the","mature","structure",".","The","flower","is","the","reproductive","structure","in","a","plant",",","and","its","development","begins","with","the","transition","of","the","vegetative","or","inflorescence","meristem","into","a","floral","meristem","."),4021275). assertion_content_comment('tOboGo_FlowerFormation',s("The","process","that","gives","rise","to","the","flower",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4103227). assertion_content_comment('tOboGo_FlowerMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","flower","are","generated","and","organized","."),4101883). assertion_content_comment('tOboGo_FlowerPhyllotacticPatterning',s("The","radial","pattern","formation","process","that","results","in","the","formation","of","flower","primordia","around","the","center","of","a","shoot","apical","meristem","."),4161043). assertion_content_comment('tOboGo_FlowerStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","flower",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4101885). assertion_content_comment('tOboGo_Fluconazole_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","H","+","(","out",")","+","fluconazole","(","in",")","=","H","+","(","in",")","+","fluconazole","(","out",")"),4296478). assertion_content_comment('tOboGo_FluconazoleTransporterActivity',s("Enables","the","directed","movement","of","fluconazole","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Fluconazole","is","an","antifungal","drug","used","for","oral","candidiasis","and","cryptococcal","meningitis",";","it","is","still","under","study","for","treatment","of","vaginal","candidiasis","and","other","fungal","infections","."),4295258). assertion_content_comment('tOboGo_FluconazoleTransport',s("The","directed","movement","of","fluconazole","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Fluconazole","is","an","antifungal","drug","used","for","oral","candidiasis","and","cryptococcal","meningitis",";","it","is","still","under","study","for","treatment","of","vaginal","candidiasis","and","other","fungal","infections","."),4294426). assertion_content_comment('tOboGo_FluidTransport',s("The","directed","movement","of","substances","that","are","in","liquid","form","in","normal","living","conditions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4004116). assertion_content_comment('tOboGo_FluoreneBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fluorene",",","a","tricyclic","polycyclic","aromatic","hydrocarbon","containing","a","five-membered","ring",".","It","is","a","major","component","of","fossil","fuels","and","their","derivatives","and","is","also","a","by-product","of","coal-conversion","and","energy-related","industries",".","It","is","commonly","found","in","vehicle","exhaust","emissions",",","crude","oils",",","motor","oils",",","coal","and","oil","combustion","products",",","waste","incineration",",","and","industrial","effluents","."),4354035). assertion_content_comment('tOboGo_FluoreneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","fluorene",",","a","tricyclic","polycyclic","aromatic","hydrocarbon","containing","a","five-membered","ring",".","It","is","a","major","component","of","fossil","fuels","and","their","derivatives","and","is","also","a","by-product","of","coal-conversion","and","energy-related","industries",".","It","is","commonly","found","in","vehicle","exhaust","emissions",",","crude","oils",",","motor","oils",",","coal","and","oil","combustion","products",",","waste","incineration",",","and","industrial","effluents","."),4240797). assertion_content_comment('tOboGo_FluoreneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fluorene",",","a","tricyclic","polycyclic","aromatic","hydrocarbon","containing","a","five-membered","ring",".","It","is","a","major","component","of","fossil","fuels","and","their","derivatives","and","is","also","a","by-product","of","coal-conversion","and","energy-related","industries",".","It","is","commonly","found","in","vehicle","exhaust","emissions",",","crude","oils",",","motor","oils",",","coal","and","oil","combustion","products",",","waste","incineration",",","and","industrial","effluents","."),4240792). assertion_content_comment('tOboGo_FluoreneOxygenaseActivity',s("Catalysis","of","the","reaction",":","fluorene","+","2","H","+","+","2","e-","+","O2","=","H2O","+","9-fluorenol","."),4275435). assertion_content_comment('tOboGo_FluoroacetaldehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","fluoroacetaldehyde","+","NAD","+","+","H2O","=","fluoroacetate","+","NADH","+","2","H","+"),4342579). assertion_content_comment('tOboGo_FluorothreonineTransaldolaseActivity',s("Catalysis","of","the","reaction",":","L-threonine","+","fluoroacetaldehyde","=","acetaldehyde","+","4-fluoro-L-threonine","."),4342940). assertion_content_comment('tOboGo_FMNAdenylyltransferaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","FMN","=","diphosphate","+","FAD","."),4184387). assertion_content_comment('tOboGo_FMNBinding',s("Interacting","selectively","and","non-covalently","with","FMN",",","flavin","mononucleotide",",","the","coenzyme","or","the","prosthetic","group","of","various","flavoprotein","oxidoreductase","enzymes","."),4333854). assertion_content_comment('tOboGo_FMNBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","FMN",",","the","oxidized","form","of","flavin","mononucleotide","(","riboflavin","5","'","-","(","dihydrogen","phosphate",")",")",",","which","acts","as","a","coenzyme","for","a","number","of","oxidative","enzymes","including","NADH","dehydrogenase","."),4260283). assertion_content_comment('tOboGo_FMNCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","FMN",",","riboflavin","5","'","-","(","dihydrogen","phosphate",")",",","a","coenzyme","for","a","number","of","oxidative","enzymes","including","NADH","dehydrogenase","."),4333686). assertion_content_comment('tOboGo_FMNMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","FMN",",","riboflavin","5","'","-","(","dihydrogen","phosphate",")",",","a","coenzyme","for","a","number","of","oxidative","enzymes","including","NADH","dehydrogenase","."),4260280). assertion_content_comment('tOboGo_FMNReductaseActivity',s("Catalysis","of","the","reaction",":","FMNH2","+","NAD","(","P",")","+","=","FMN","+","NAD","(","P",")","H","+","H","+"),4251525). assertion_content_comment('tOboGo_FoamCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","foam","cell",".","A","foam","cell","is","a","type","of","cell","containing","lipids","in","small","vacuoles","and","typically","seen","in","atherosclerotic","lesions",",","as","well","as","other","conditions","."),4024641). assertion_content_comment('tOboGo_FocalAdhesionAssembly',s("The","aggregation","and","bonding","together","of","a","set","of","components","to","form","a","focal","adhesion",",","a","complex","of","intracellular","signaling","and","structural","proteins","that","provides","a","structural","link","between","the","internal","actin","cytoskeleton","and","the","ECM",",","and","also","function","as","a","locus","of","signal","transduction","activity","."),4104609). assertion_content_comment('tOboGo_FocalAdhesionKinaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4201063). assertion_content_comment('tOboGo_FocalAdhesion',s("Small","region","on","the","surface","of","a","cell","that","anchors","the","cell","to","the","extracellular","matrix","and","that","forms","a","point","of","termination","of","actin","filaments","."),4220685). assertion_content_comment('tOboGo_FolateReductaseActivity',s("Catalysis","of","the","reaction",":","7",",","8-dihydrofolate","+","NADP","+","=","folate","+","NADPH","+","H","+"),4341103). assertion_content_comment('tOboGo_FolicAcidBinding',s("Interacting","selectively","and","non-covalently","with","folic","acid",",","pteroylglutamic","acid",".","Folic","acid","is","widely","distributed","as","a","member","of","the","vitamin","B","complex","and","is","essential","for","the","synthesis","of","purine","and","pyrimidines","."),4218977). assertion_content_comment('tOboGo_FolicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","folic","acid",",","pteroylglutamic","acid","."),4359870). assertion_content_comment('tOboGo_FolicAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","folic","acid",",","pteroylglutamic","acid","."),4359848). assertion_content_comment('tOboGo_FolicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","folic","acid",",","pteroylglutamic","acid",".","Folic","acid","is","widely","distributed","as","a","member","of","the","vitamin","B","complex","and","is","essential","for","the","synthesis","of","purine","and","pyrimidines","."),4359828). assertion_content_comment('tOboGo_FolicAcidTransporterActivity',s("Enables","the","directed","movement","of","folic","acid","(","pteroylglutamic","acid",")","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Folic","acid","is","widely","distributed","as","a","member","of","the","vitamin","B","complex","and","is","essential","for","the","synthesis","of","purine","and","pyrimidines","."),4254551). assertion_content_comment('tOboGo_FolicAcidTransport',s("The","directed","movement","of","folic","acid","(","pteroylglutamic","acid",")","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Folic","acid","is","widely","distributed","as","a","member","of","the","vitamin","B","complex","and","is","essential","for","the","synthesis","of","purine","and","pyrimidines","."),4294229). assertion_content_comment('tOboGo_FollicleCellMicrovillusOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","microvillus","on","a","follicle","cell",".","A","microvillus","is","a","thin","cylindrical","membrane-covered","projection","on","the","surface","of","an","animal","cell","containing","a","core","bundle","of","actin","filaments","."),4067382). assertion_content_comment('tOboGo_FollicularBCellDifferentiation',s("The","process","in","which","a","B","cell","in","the","spleen","acquires","the","specialized","features","of","a","follicular","B","cell",".","Follicular","B","cells","are","major","population","of","mature","recirculating","B","cells","in","the","spleen","and","are","located","in","the","B-cell","follicle","region","."),4380495). assertion_content_comment('tOboGo_FollicularDendriticCellActivationInvolvedInImmuneResponse',s("A","change","in","the","morphology","or","behavior","of","a","follicular","dendritic","cell","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),4378041). assertion_content_comment('tOboGo_FollicularDendriticCellActivation',s("A","change","in","the","morphology","or","behavior","of","a","follicular","dendritic","cell","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand","."),4378031). assertion_content_comment('tOboGo_FollicularDendriticCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","precursor","cell","acquires","the","specialized","features","of","a","follicular","dendritic","cell","."),4378051). assertion_content_comment('tOboGo_FollicularFluidFormationInOvarianFollicleAntrumInvolvedInDistinctAntralSpacesStage',s("The","menstrual","cycle","process","in","which","one","central","cavity","separating","the","oocyte/cumulus","complex","from","mural","granulosa","and","theca","cells","is","formed","as","part","of","the","antral","spaces","stage","of","oogenesis","."),3998993). assertion_content_comment('tOboGo_FollicularFluidFormationInOvarianFollicleAntrumInvolvedInFusedAntrumStage',s("The","ovulation","cycle","process","in","which","one","central","cavity","separating","the","oocyte/cumulus","complex","from","mural","granulosa","and","theca","cells","is","formed","as","part","of","the","fused","antrum","stage","of","oogenesis","."),3999798). assertion_content_comment('tOboGo_FollicularFluidFormationInOvarianFollicleAntrumInvolvedInScatteredAntralSpacesStage',s("The","menstrual","cycle","process","in","which","one","central","cavity","separating","the","oocyte/cumulus","complex","from","mural","granulosa","and","theca","cells","is","formed","as","part","of","the","scattered","antral","spaces","stage","of","oogenesis","."),3999014). assertion_content_comment('tOboGo_FollicularFluidFormationInOvarianFollicleAntrum',s("The","menstrual","cycle","process","that","results","in","the","formation","of","one","central","cavity","separating","the","oocyte/cumulus","complex","from","mural","granulosa","and","theca","cells","during","the","various","stages","of","oogenesis","."),3981345). assertion_content_comment('tOboGo_FollistatinBinding',s("Interacting","selectively","and","non-covalently","with","the","peptide","hormone","follistatin","."),4385026). assertion_content_comment('tOboGo_FoodVacuole',s("Vacuole","within","a","parasite","used","for","digestion","of","the","host","cell","cytoplasm",".","An","example","of","this","component","is","found","in","the","Apicomplexa","."),4080025). assertion_content_comment('tOboGo_FootLayer',s("The","inner","layer","of","the","ectexine","."),4095020). assertion_content_comment('tOboGo_ForagingBehaviorByProbingSubstrate',s("Foraging","behavior","in","which","an","anatomical","part","of","the","organism","is","inserted","into","the","substrate","to","locate","food","."),4161079). assertion_content_comment('tOboGo_ForagingBehavior',s("Behavior","by","which","an","organism","locates","food","."),4161070). assertion_content_comment('tOboGo_ForebrainAnteriorPosteriorPatternFormation',s("The","creation","of","specific","areas","of","progenitor","domains","along","the","anterior-posterior","axis","of","the","developing","forebrain","."),4049575). assertion_content_comment('tOboGo_ForebrainAstrocyteDevelopment',s("The","process","aimed","at","the","progression","of","an","astrocyte","that","resides","in","the","forebrain",",","from","initial","commitment","of","the","cell","to","its","fate",",","to","the","fully","functional","differentiated","cell",".","An","astrocyte","is","the","most","abundant","type","of","glial","cell",".","Astrocytes","provide","support","for","neurons","and","regulate","the","environment","in","which","they","function","."),4047709). assertion_content_comment('tOboGo_ForebrainAstrocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","astrocyte","residing","in","the","forebrain",".","An","astrocyte","is","the","most","abundant","type","of","glial","cell",".","Astrocytes","provide","support","for","neurons","and","regulate","the","environment","in","which","they","function","."),4047479). 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assertion_content_comment('tOboGo_FormationOfTranslationInitiationTernaryComplex',s("Formation","of","a","complex","between","aminoacylated","initiator","methionine","tRNA",",","GTP",",","and","initiation","factor","2","(","either","eIF2","in","eukaryotes",",","or","IF2","in","prokaryotes",")","In","prokaryotes",",","fMet-tRNA","(","initiator",")","is","used","rather","than","Met-tRNA","(","initiator",")"),3982196). assertion_content_comment('tOboGo_FormationOfTranslationPreinitiationComplex',s("The","joining","of","the","small","ribosomal","subunit",",","ternary","complex",",","and","mRNA","."),3982298). assertion_content_comment('tOboGo_FormicAcidSecretion',s("The","controlled","release","of","formic","acid",",","HCOOH",",","by","a","cell","or","group","of","cells","."),4356916). assertion_content_comment('tOboGo_FormimidoylaspartateDeiminaseActivity',s("Catalysis","of","the","reaction",":","N-formimidoyl-L-aspartate","+","H2O","=","N-formyl-L-aspartate","+","NH3","."),4266622). assertion_content_comment('tOboGo_FormimidoylglutamaseActivity',s("Catalysis","of","the","reaction",":","N-formimidoyl-L-glutamate","+","H","(","2",")","O","=","L-glutamate","+","formamide","."),4266583). assertion_content_comment('tOboGo_FormimidoylglutamateDeiminaseActivity',s("Catalysis","of","the","reaction",":","N-formimidoyl-L-glutamate","+","H2O","=","N-formyl-L-glutamate","+","NH3","."),4266598). assertion_content_comment('tOboGo_FormimidoyltetrahydrofolateCyclodeaminaseActivity',s("Catalysis","of","the","reaction",":","5-formimidoyltetrahydrofolate","+","2","H","(","+",")","=","5",",","10-methenyltetrahydrofolate","+","NH","(","4",")","(","+",")"),4309965). assertion_content_comment('tOboGo_FormimidoyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","formimino","group","from","5-formimidoyltetrahydrofolate","to","an","acceptor","molecule","such","as","an","amino","acid","."),4310185). 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assertion_content_comment('tOboGo_FormyltetrahydrofolateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","10-formyltetrahydrofolate","+","H","(","2",")","O","+","NADP","(","+",")","=","(","6S",")","-5",",","6",",","7",",","8-tetrahydrofolate","+","CO","(","2",")","+","H","(","+",")","+","NADPH","."),4303193). assertion_content_comment('tOboGo_ForwardLocomotion',s("Anterior","movement","of","an","organism",",","following","the","direction","of","the","head","of","the","animal","."),4094308). assertion_content_comment('tOboGo_FosmidomycinTransporterActivity',s("Enables","the","directed","movement","of","fosmidomycin",",","a","phosphonic","acid","derivative","with","potent","activity","against","Gram-negative","organisms",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4315066). assertion_content_comment('tOboGo_FosmidomycinTransport',s("The","directed","movement","of","fosmidomycin",",","a","phosphonic","acid","derivative","with","potent","activity","against","Gram-negative","organisms",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4314920). assertion_content_comment('tOboGo_FourthVentricleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","fourth","ventricle","over","time",",","from","its","formation","to","the","mature","structure",".","The","fourth","ventricle","is","an","irregularly","shaped","cavity","in","the","rhombencephalon",",","between","the","medulla","oblongata",",","the","pons",",","and","the","isthmus","in","front",",","and","the","cerebellum","behind",".","It","is","continuous","with","the","central","canal","of","the","cord","below","and","with","the","cerebral","aqueduct","above",",","and","through","its","lateral","and","median","apertures","it","communicates","with","the","subarachnoid","space","."),4044624). assertion_content_comment('tOboGo_FractalkineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fractalkine",",","a","chemokine","involved","in","the","control","of","the","key","regulatory","mechanisms","of","cell","trafficking","at","sites","of","inflammation",".","It","exists","as","a","secreted","protein","and","in","a","membrane-bound","form",",","and","exhibits","a","novel","C-X-X-X-C","cysteine","signature","motif",".","The","counterpart","of","human","fractalkine","is","murine","neurotactin",";","fractalkine","is","also","referred","to","as","CX3C","membrane-anchored","chemokine","or","ABCD-3","and","has","been","renamed","CX3CL1","."),4101143). assertion_content_comment('tOboGo_FractalkineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fractalkine",",","a","chemokine","involved","in","the","control","of","the","key","regulatory","mechanisms","of","cell","trafficking","at","sites","of","inflammation",".","It","exists","as","a","secreted","protein","and","in","a","membrane-bound","form",",","and","exhibits","a","novel","C-X-X-X-C","cysteine","signature","motif",".","The","counterpart","of","human","fractalkine","is","murine","neurotactin",";","fractalkine","is","also","referred","to","as","CX3C","membrane-anchored","chemokine","or","ABCD-3","and","has","been","renamed","CX3CL1","."),4101131). assertion_content_comment('tOboGo_FractalkineProduction',s("The","appearance","of","fractalkine","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4066937). assertion_content_comment('tOboGo_FreeSarcoplasmicReticulumMembrane',s("The","part","of","the","sarcoplasmic","reticulum","membrane","that","contains","calcium","pumps","and","is","devoted","to","calcium","uptake",".","The","free","sarcoplasmic","reticulum","membrane","consists","of","the","longitudinal","sarcoplasmic","reticulum","membrane","and","the","non-junctional","region","of","the","terminal","cisterna","membrane","."),4320743). assertion_content_comment('tOboGo_FreeUbiquitinChainDepolymerization',s("The","process","in","which","free","ubiquitin","chains",",","compounds","composed","of","a","large","number","of","ubiquitin","monomers",",","are","broken","down","."),4035867). assertion_content_comment('tOboGo_FreeUbiquitinChainPolymerization',s("The","process","of","creating","free","ubiquitin","chains",",","compounds","composed","of","a","large","number","of","ubiquitin","monomers",".","These","chains","are","not","conjugated","to","a","protein","."),4035857). assertion_content_comment('tOboGo_FreezingTolerance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4261158). assertion_content_comment('tOboGo_FrizzledBinding',s("Interacting","selectively","and","non-covalently","with","the","frizzled","(","fz",")","receptor","."),4214321). assertion_content_comment('tOboGo_FrizzledReceptorActivity',s("OBSOLETE",".","Combining","with","a","member","of","the","Wnt-family","of","signaling","molecules","to","initiate","a","change","in","cell","activity","."),4198493). assertion_content_comment('tOboGo_FrontalSutureMorphogenesis',s("The","process","in","which","the","frontal","suture","is","generated","and","organized","."),4160273). assertion_content_comment('tOboGo_FructanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fructan","a","polysaccharide","consisting","of","fructose","residues","."),4334135). assertion_content_comment('tOboGo_FructanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","fructan",",","a","polysaccharide","consisting","of","fructose","residues","."),4334110). assertion_content_comment('tOboGo_FructanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fructan",",","a","polysaccharide","consisting","of","fructose","residues","."),4334105). assertion_content_comment('tOboGo_FructokinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","D-fructose","=","ADP","+","D-fructose","6-phosphate","."),4249626). assertion_content_comment('tOboGo_FructosamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fructosamine",",","a","fructose","molecule","containing","an","amino","group","in","place","of","a","hydroxyl","group","."),4309380). assertion_content_comment('tOboGo_FructosamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","fructosamine",",","a","fructose","molecule","containing","an","amino","group","in","place","of","a","hydroxyl","group","."),4309324). assertion_content_comment('tOboGo_FructosamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fructosamine",",","a","fructose","molecule","containing","an","amino","group","in","place","of","a","hydroxyl","group","."),4309312). assertion_content_comment('tOboGo_FructoseBinding',s("Interacting","selectively","and","non-covalently","with","the","D-","or","L-enantiomer","of","fructose",",","the","ketohexose","arabino-hex-2-ulose","."),4180073). assertion_content_comment('tOboGo_FructoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fructose",",","the","ketohexose","arabino-2-hexulose","."),4348964). 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assertion_content_comment('tOboGo_FructoselysineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fructoselysine",",","a","fructose","molecule","containing","a","lysine","group","in","place","of","a","hydroxyl","group","."),4309338). assertion_content_comment('tOboGo_FructoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fructose",",","the","ketohexose","arabino-2-hexulose",".","Fructose","exists","in","a","open","chain","form","or","as","a","ring","compound",".","D-fructose","is","the","sweetest","of","the","sugars","and","is","found","free","in","a","large","number","of","fruits","and","honey","."),4116398). assertion_content_comment('tOboGo_FructoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","fructose","from","one","side","of","the","membrane","to","the","other",".","Fructose","exists","in","a","open","chain","form","or","as","a","ring","compound",".","D-fructose","is","the","sweetest","of","the","sugars","and","is","found","free","in","a","large","number","of","fruits","and","honey","."),4216543). assertion_content_comment('tOboGo_FructoseTransport',s("The","directed","movement","of","fructose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Fructose","exists","in","a","open","chain","form","or","as","a","ring","compound",".","D-fructose","is","the","sweetest","of","the","sugars","and","is","found","free","in","a","large","number","of","fruits","and","honey","."),4291082). assertion_content_comment('tOboGo_FructoseUniporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","fructose","(","out",")","=","fructose","(","in",")"),4295154). assertion_content_comment('tOboGo_FructosyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","fructosyl","group","to","an","acceptor","molecule",",","typically","another","carbohydrate","or","a","lipid","."),4265740). assertion_content_comment('tOboGo_FructuronateReductaseActivity',s("Catalysis","of","the","reaction",":","D-mannonate","+","NAD","(","+",")","=","D-fructuronate","+","H","(","+",")","+","NADH","."),4249640). assertion_content_comment('tOboGo_FruitAbscission',s("The","controlled","shedding","of","a","fruit","."),4156440). assertion_content_comment('tOboGo_FruitDehiscence',s("The","process","leading","to","the","spontaneous","opening","of","the","fruit","permitting","the","escape","of","seeds","."),4329989). assertion_content_comment('tOboGo_FruitDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","fruit","over","time",",","from","its","formation","to","the","mature","structure",".","The","fruit","is","a","reproductive","body","of","a","seed","plant","."),4021639). assertion_content_comment('tOboGo_FruitingBodyDevelopmentInCellularResponseToStarvation',s("The","process","whose","specific","outcome","is","the","progression","of","the","fruiting","body","over","time",",","from","its","formation","to","the","mature","structure",".","The","process","begins","when","cells","respond","to","a","lack","of","nutrients","in","the","environment","and","ends","when","the","fruiting","body","is","a","mature","structure","."),4307739). assertion_content_comment('tOboGo_FruitingBodyDevelopmentInResponseToStarvation',s("The","process","whose","specific","outcome","is","the","progression","of","the","fruiting","body","over","time",",","from","its","formation","to","the","mature","structure",".","The","process","begins","with","a","response","to","a","lack","of","nutrients","and","ends","when","the","fruiting","body","is","a","mature","structure","."),4051765). assertion_content_comment('tOboGo_FruitingBodyDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","fruiting","body","over","time",",","from","its","formation","to","the","mature","structure",".","A","fruiting","body","is","a","multicellular","structure","that","contains","spores","."),3978779). assertion_content_comment('tOboGo_FruitMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","fruit","are","generated","and","organized",".","A","fruit","is","a","reproductive","body","of","a","seed","plant","."),4103079). assertion_content_comment('tOboGo_FruitSeptumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","fruit","septum","over","time",",","from","its","formation","to","the","mature","structure",".","The","fruit","septum","is","a","thin","partition","or","membrane","that","divides","a","cavity","or","a","mass","of","tissue","in","the","fruit","."),4147528). assertion_content_comment('tOboGo_FucoidanaseActivity',s("Catalysis","of","the","endohydrolysis","of","1",",","2-alpha-L-fucoside","linkages","in","fucoidan","without","release","of","sulfate","."),4344133). assertion_content_comment('tOboGo_FucokinaseActivity',s("Catalysis","of","the","reaction",":","L-fucose","+","ATP","=","beta-L-fucose","1-phosphate","+","ADP","+","2","H","(","+",")"),4264401). assertion_content_comment('tOboGo_FucoseBinding',s("Interacting","selectively","and","non-covalently","with","fucose",",","the","pentose","6-deoxygalactose","."),4314725). assertion_content_comment('tOboGo_FucoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fucose","(","6-deoxygalactose",")"),4225150). assertion_content_comment('tOboGo_FucoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","fucose","(","6-deoxygalactose",")"),4095998). assertion_content_comment('tOboGo_Fucose_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","fucose","(","out",")","+","H","+","(","out",")","=","fucose","(","in",")","+","H","+","(","in",")"),4293118). assertion_content_comment('tOboGo_FucoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fucose",",","or","6-deoxygalactose",",","which","has","two","enantiomers",",","D-fucose","and","L-fucose","."),4095994). assertion_content_comment('tOboGo_FucoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","fucose","from","one","side","of","the","membrane","to","the","other",".","Fucose","is","6-deoxygalactose","and","has","two","enantiomers",",","D-fucose","and","L-fucose","."),4293116). assertion_content_comment('tOboGo_FucoseTransport',s("The","directed","movement","of","fucose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Fucose","is","6-deoxygalactose","and","has","two","enantiomers",",","D-fucose","and","L-fucose","."),4291092). assertion_content_comment('tOboGo_FucosidaseActivity',s("Catalysis","of","the","hydrolysis","of","fucosyl","compounds",",","substances","containing","a","group","derived","from","a","cyclic","form","of","fucose","or","a","fucose","derivative","."),4204617). assertion_content_comment('tOboGo_FucosyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","fucosyl","group","to","an","acceptor","molecule",",","typically","another","carbohydrate","or","a","lipid","."),4246441). assertion_content_comment('tOboGo_FullySpanningThePlasmaMembrane',s("Fully","spanning","both","phospholipid","bilayers","of","a","plasma","membrane","."),4288227). assertion_content_comment('tOboGo_FumarateHydrataseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-malate","=","fumarate","+","H","(","2",")","O","."),4208365). assertion_content_comment('tOboGo_FumarateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","fumarate",",","the","anion","of","trans-1",",","2-ethenedicarboxylic","acid",",","the","diastereoisomer","of","maleate",".","It","is","a","key","intermediate","in","metabolism","and","is","formed","in","the","TCA","cycle","from","succinate","and","converted","into","malate","."),4224426). assertion_content_comment('tOboGo_FumarateReductaseComplex',s("A","membrane-bound","flavoenzyme","complex","consisting","of","four","subunits",",","A",",","B",",","C",",","and","D",".","A","and","B","comprise","the","membrane-extrinsic","catalytic","domain","and","C","(","InterPro",":","IPR003510",";","InterPro",":","IPR004224",")","and","D","(","InterPro",":","IPR003418",")","link","the","catalytic","centers","to","the","electron-transport","chain",".","This","family","consists","of","the","13","kDa","hydrophobic","subunit","D",".","This","component","may","be","required","to","anchor","the","catalytic","components","of","the","fumarate","reductase","complex","to","the","cytoplasmic","membrane",".","Fumarate","reductase","couples","the","reduction","of","fumarate","to","succinate","to","the","oxidation","of","quinol","to","quinone",",","in","a","reaction","opposite","to","that","catalyzed","by","the","related","complex","II","of","the","respiratory","chain","(","succinate","dehydrogenase-","(","ubiquinone",")",")"),4007564). assertion_content_comment('tOboGo_FumarateReductaseNADHActivity',s("Catalysis","of","the","reaction",":","NAD","(","+",")","+","succinate","=","fumarate","+","H","(","+",")","+","NADH","."),4303181). assertion_content_comment('tOboGo_FumarateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","fumarate","from","one","side","of","the","membrane","to","the","other",".","Fumarate","is","a","key","intermediate","in","metabolism","and","is","formed","in","the","TCA","cycle","from","succinate","and","converted","into","malate","."),4219512). assertion_content_comment('tOboGo_FumarateTransport',s("The","directed","movement","of","fumarate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290783). assertion_content_comment('tOboGo_FumarylacetoacetaseActivity',s("Catalysis","of","the","reaction",":","4-fumarylacetoacetate","+","H","(","2",")","O","=","acetoacetate","+","fumarate","+","H","(","+",")"),4208399). assertion_content_comment('tOboGo_FumarylpyruvateHydrolaseActivity',s("Catalysis","of","the","reaction",":","fumarylpyruvate","+","H2O","=","fumarate","+","pyruvate","+","H","+"),4352768). assertion_content_comment('tOboGo_FungiformPapillaDevelopment',s("The","progression","of","the","fungiform","papilla","over","time",",","from","its","formation","to","the","mature","structure",".","The","fungiform","papilla","is","a","mushroom-shaped","papilla","of","the","tongue","."),4135949). assertion_content_comment('tOboGo_FungiformPapillaFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","spongiform","papilla","from","unspecified","parts",".","The","fungiform","papilla","is","a","mushroom-shaped","papilla","of","the","tongue","."),4136022). assertion_content_comment('tOboGo_FungiformPapillaMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","fungiform","papilla","are","generated","and","organized",".","The","fungiform","papilla","is","a","mushroom-shaped","papilla","of","the","tongue","."),4135960). assertion_content_comment('tOboGo_FuraldehydeMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","furaldehyde",",","a","furan","ring-containing","aldehyde","compound","which","can","be","formed","from","the","thermal","decomposition","of","biomass","."),4343734). assertion_content_comment('tOboGo_FurinActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","mature","proteins","from","their","proproteins","by","cleavage","of","the","terminal","bond","of","Arg-Xaa-Yaa-Arg-Z","motifs","where","Xaa","can","be","any","amino","acid","and","Yaa","is","Arg","or","Lys",".","Releases","albumin",",","complement","component","C3","and","von","Willebrand","factor","from","their","respective","precursors","."),4209473). assertion_content_comment('tOboGo_FurylfuramideIsomeraseActivity',s("Catalysis","of","the","reaction",":","(","E",")","-2-","(","2-furyl",")","-3-","(","5-nitro-2-furyl",")","acrylamide","=","(","Z",")","-2-","(","2-furyl",")","-3-","(","5-nitro-2-furyl",")","acrylamide","."),4377978). assertion_content_comment('tOboGo_FusedAntrumStage',s("The","stage","in","oogenesis","when","the","antral","spaces","fuse","to","form","a","single","antral","space",".","The","oocyte","is","suspended","in","the","cumulus","oophorous","and","the","first","polar","body","in","the","perivitelline","space","."),3981233). assertion_content_comment('tOboGo_FusionCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","fusion","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed",".","Fusion","cells","allow","the","interconnection","of","adjacent","tracheal","metameres","during","tracheal","tube","fusion","."),4071779). assertion_content_comment('tOboGo_FusionOfSpermToEggPlasmaMembrane',s("The","binding","and","fusion","of","a","sperm",",","having","penetrated","the","zona","pellucida",",","with","the","plasma","membrane","of","the","oocyte",".","Binding","occurs","at","the","posterior","(","post-acrosomal",")","region","of","the","sperm","head","."),4019180). assertion_content_comment('tOboGo_FusomeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","fusome",",","a","large","intracellular","spectrin-rich","structure","found","in","insect","germline","cells","and","mammalian","hematopoietic","cells","."),4052000). assertion_content_comment('tOboGo_Fusome',s("A","large","intracellular","spectrin-rich","structure","that","has","been","found","in","insect","germline","cells","and","mammalian","hematopoietic","cells",".","The","fusome","is","an","elongated",",","branched","structure",",","formed","from","the","spherical","spectrosome","organelle","."),4300349). assertion_content_comment('tOboGo_G0ToG1Transition',s("The","transition","from","the","G0","quiescent","state","to","the","G1","phase",".","Under","certain","conditions",",","cells","exit","the","cell","cycle","during","G1","and","remain","in","the","G0","state","as","nongrowing",",","non-dividing","(","quiescent",")","cells",".","Appropriate","stimulation","of","such","cells","induces","them","to","return","to","G1","and","resume","growth","and","division",".","The","G0","to","G1","transition","is","accompanied","by","many","changes","in","the","program","of","gene","expression","."),4137280). assertion_content_comment('tOboGo_G1CellCycleArrestInResponseToNitrogenStarvation',s("The","process","in","which","the","cell","cycle","is","halted","during","G1","phase",",","as","a","result","of","deprivation","of","nitrogen","."),4170983). assertion_content_comment('tOboGo_G1PhaseOfMeioticCellCycle',s("G1","phase","occurring","as","part","of","the","meiotic","cell","cycle",".","G1","phase","is","the","interval","between","the","completion","of","DNA","segregation","(","meiosis","in","a","meiotic","cell","cycle",")","and","the","beginning","of","DNA","synthesis",".","A","meiotic","cell","cycle","is","one","in","which","canonically","a","cell","replicates","to","produce","four","offspring","with","half","the","chromosomal","content","of","the","progenitor","cell","."),4117952). assertion_content_comment('tOboGo_G1PhaseOfMitoticCellCycle',s("G1","phase","occurring","as","part","of","the","mitotic","cell","cycle",".","G1","phase","is","the","interval","between","the","completion","of","DNA","segregation","(","mitosis","in","a","mitotic","cell","cycle",")","and","the","beginning","of","DNA","synthesis",".","A","mitotic","cell","cycle","is","one","which","canonically","comprises","four","successive","phases","called","G1",",","S",",","G2",",","and","M","and","includes","replication","of","the","genome","and","the","subsequent","segregation","of","chromosomes","into","daughter","cells","."),3970789). assertion_content_comment('tOboGo_G1Phase',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","G1","phase",",","one","of","two","'","gap","'","phases","in","the","cell","cycle",";","G1","is","the","interval","between","the","completion","of","DNA","segregation","(","usually","by","mitosis","or","meiosis",")","and","the","beginning","of","DNA","synthesis","."),3970786). assertion_content_comment('tOboGo_G1STransitionCheckpoint',s("A","cell","cycle","checkpoint","that","blocks","entry","into","S","phase","."),4060368). assertion_content_comment('tOboGo_G1STransitionOfMitoticCellCycle',s("Progression","from","G1","phase","to","S","phase","of","the","mitotic","cell","cycle","."),3970799). assertion_content_comment('tOboGo_G1ToG0TransitionInvolvedInCellDifferentiation',s("A","cell","cycle","arrest","process","that","results","in","arrest","during","G1","phase",",","whereupon","the","cell","enters","G0","phase",",","in","the","context","of","cell","differentiation","."),4137340). assertion_content_comment('tOboGo_G1ToG0Transition',s("A","cell","cycle","arrest","process","that","results","in","arrest","during","G1","phase",",","whereupon","the","cell","enters","a","specialized","resting","state","known","as","G0","or","quiescence","."),4137334). assertion_content_comment('tOboGo_G2MTransitionCheckpoint',s("A","cell","cycle","checkpoint","that","blocks","entry","into","M","phase","."),4126784). assertion_content_comment('tOboGo_G2MTransitionDNADamageCheckpoint',s("A","cell","cycle","checkpoint","that","blocks","cell","cycle","progression","from","G2","to","M","phase","in","response","to","DNA","damage","."),4128034). assertion_content_comment('tOboGo_G2MTransitionOfMitoticCellCycle',s("Progression","from","G2","phase","to","M","phase","of","the","mitotic","cell","cycle","."),3971142). assertion_content_comment('tOboGo_G2MTransitionSizeControlCheckpoint',s("A","cell","cycle","checkpoint","that","blocks","cell","cycle","progression","from","G2","to","M","phase","until","cells","have","reached","a","critical","size","."),4127738). assertion_content_comment('tOboGo_G2PhaseOfMeioticCellCycle',s("G2","phase","occurring","as","part","of","the","meiotic","cell","cycle",".","G2","phase","is","the","interval","between","the","completion","of","DNA","synthesis","and","the","beginning","of","DNA","segregation","(","meiosis","in","a","meiotic","cell","cycle",")","A","meiotic","cell","cycle","is","one","in","which","canonically","a","cell","replicates","to","produce","four","offspring","with","half","the","chromosomal","content","of","the","progenitor","cell","."),4117984). assertion_content_comment('tOboGo_G2PhaseOfMitoticCellCycle',s("G2","phase","occurring","as","part","of","the","mitotic","cell","cycle",".","G2","phase","is","the","interval","between","the","completion","of","DNA","synthesis","and","the","beginning","of","DNA","segregation","(","mitosis","in","a","mitotic","cell","cycle",")","A","mitotic","cell","cycle","is","one","which","canonically","comprises","four","successive","phases","called","G1",",","S",",","G2",",","and","M","and","includes","replication","of","the","genome","and","the","subsequent","segregation","of","chromosomes","into","daughter","cells","."),3971110). assertion_content_comment('tOboGo_G2Phase',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","G2","phase",",","one","of","two","'","gap","'","phases","in","the","cell","cycle",";","G2","is","the","interval","between","the","completion","of","DNA","synthesis","and","the","beginning","of","DNA","segregation","(","usually","by","mitosis","or","meiosis",")"),3971107). assertion_content_comment('tOboGo_GABAergicNeuronDifferentiationInBasalGanglia',s("The","process","in","which","a","neuroblast","acquires","the","specialized","structural","and","functional","features","of","a","GABAergic","inhibitory","neuron","in","the","basal","ganglia",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","neuroblast","to","a","GABAergic","neuron","."),4050674). assertion_content_comment('tOboGo_GABAReceptorActivity',s("Combining","with","gamma-aminobutyric","acid","(","GABA",",","4-aminobutyrate",")",",","an","amino","acid","which","acts","as","a","neurotransmitter","in","some","organisms",",","to","initiate","a","change","in","cell","activity","."),4198150). assertion_content_comment('tOboGo_GABAReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","gamma-aminobutyric","acid","(","GABA",",","4-aminobutyrate",")","receptor","."),4247055). assertion_content_comment('tOboGo_GalactarateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","galactarate",",","the","anion","of","galactaric","acid","."),4315318). assertion_content_comment('tOboGo_GalactarateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galactarate",",","the","anion","of","galactaric","acid","."),4243107). assertion_content_comment('tOboGo_GalactarateDehydrataseActivity',s("Catalysis","of","the","reaction",":","galactarate","=","5-dehydro-4-deoxy-D-glucarate","+","H","(","2",")","O","."),4249603). assertion_content_comment('tOboGo_GalactarateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactarate",",","an","anion","of","galactaric","acid",",","the","meso-aldaric","acid","derived","from","both","D-","and","L-galactose","."),4243102). assertion_content_comment('tOboGo_GalactitolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","galactitol",",","the","hexitol","derived","by","the","reduction","of","the","aldehyde","group","of","either","D-","or","L-galactose","."),4240607). assertion_content_comment('tOboGo_GalactitolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galactitol",",","the","hexitol","derived","by","the","reduction","of","the","aldehyde","group","of","either","D-","or","L-galactose","."),4240622). assertion_content_comment('tOboGo_GalactitolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactitol",",","the","hexitol","derived","by","the","reduction","of","the","aldehyde","group","of","either","D-","or","L-galactose","."),4240595). assertion_content_comment('tOboGo_GalactitolTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","galactitol","from","one","side","of","the","membrane","to","the","other",".","Galactitol","is","the","hexitol","derived","by","the","reduction","of","the","aldehyde","group","of","either","D-","or","L-galactose","."),4293523). assertion_content_comment('tOboGo_GalactitolTransport',s("The","directed","movement","of","galactitol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Galactitol","is","the","hexitol","derived","by","the","reduction","of","the","aldehyde","group","of","either","D-","or","L-galactose","."),4290948). assertion_content_comment('tOboGo_GalactoglucomannanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactoglucomannan",",","a","polysaccharide","composed","of","D-glucose",",","D-galactose","and","D-mannose",".","The","mannose","units","form","the","backbone","structure","(","a","linear","main","chain",")","decorated","with","a","mixture","of","D-glucose","and","D-galactose","side-units","."),4332157). assertion_content_comment('tOboGo_GalactokinaseActivity',s("Catalysis","of","the","reaction",":","D-galactose","+","ATP","=","alpha-D-galactose","1-phosphate","+","ADP","+","2","H","(","+",")"),4208324). assertion_content_comment('tOboGo_GalactolipaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-diacyl-3-beta-D-galactosyl-sn-glycerol","+","2","H2O","=","3-beta-D-galactosyl-sn-glycerol","+","2","carboxylates","."),4374241). assertion_content_comment('tOboGo_GalactolipidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","galactolipids",",","any","glycolipid","containing","one","of","more","residues","of","galactose","and/or","N-acetylgalactosamine","."),4230800). assertion_content_comment('tOboGo_GalactolipidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galactolipids",",","any","glycolipid","containing","one","of","more","residues","of","galactose","and/or","N-acetylgalactosamine","."),4230989). assertion_content_comment('tOboGo_GalactolipidGalactosyltransferaseActivity',s("Catalysis","of","the","reaction",":","2","mono-beta-D-galactosyldiacylglycerol","=","alpha-D-galactosyl-beta-D-galactosyldiacylglycerol","+","1",",","2-diacylglycerol","."),4350119). assertion_content_comment('tOboGo_GalactolipidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactolipids",",","any","glycolipid","containing","one","of","more","residues","of","galactose","and/or","N-acetylgalactosamine","."),4230775). assertion_content_comment('tOboGo_GalactomannanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","galactomannan",",","a","polysaccharide","composed","of","D-galactosyl","and","D-mannosyl",".","The","mannosyl","units","form","the","backbone","structure","(","a","linear","main","chain",")","with","the","D-galactosyl","as","single","side","units","."),4287026). assertion_content_comment('tOboGo_GalactomannanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galactomannan",",","a","polysaccharide","composed","of","D-galactosyl","and","D-mannosyl",".","The","mannosyl","units","form","the","backbone","structure","(","a","linear","main","chain",")","with","the","D-galactosyl","as","single","side","units","."),4285574). assertion_content_comment('tOboGo_GalactomannanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactomannan",",","a","polysaccharide","composed","of","D-galactose","and","D-mannose",".","The","mannose","units","form","the","backbone","structure","(","a","linear","main","chain",")","with","the","D-galactose","as","single","side","units","."),4285571). assertion_content_comment('tOboGo_GalactonateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galactonate",",","the","anion","of","galactonic","acid","."),4243139). assertion_content_comment('tOboGo_GalactonateDehydrataseActivity',s("Catalysis","of","the","reaction",":","D-galactonate","=","2-dehydro-3-deoxy-D-galactonate","+","H","(","2",")","O","."),4249589). assertion_content_comment('tOboGo_GalactonateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactonate",",","the","anion","of","galactonic","acid",",","an","organic","acid","derived","from","the","sugar","galactose","."),4243074). assertion_content_comment('tOboGo_GalactonolactoneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-galactono-1",",","4-lactone","+","2","ferricytochrome","c","=","L-ascorbate","+","2","ferrocytochrome","c","."),4305789). assertion_content_comment('tOboGo_GalactosamineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","galactosamine","from","one","side","of","the","membrane","to","the","other",".","Galactosamine","is","an","aminodeoxysugar",";","D-galactosamine","is","a","constituent","of","some","glycolipids","and","glycosaminoglycans",",","commonly","as","its","N-acetyl","derivative","."),4237895). assertion_content_comment('tOboGo_GalactosaminoglycanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","galactosaminoglycans",",","any","of","a","group","of","polysaccharides","that","contain","amino","sugars","derived","from","the","galactose","."),4225467). assertion_content_comment('tOboGo_GalactosaminoglycanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galactosaminoglycans",",","any","of","a","group","of","polysaccharides","that","contain","amino","sugars","derived","from","the","galactose","."),4225518). assertion_content_comment('tOboGo_GalactosaminoglycanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactosaminoglycans",",","any","one","of","a","group","of","polysaccharides","that","contain","amino","sugars","derived","from","the","galactose","."),4225464). assertion_content_comment('tOboGo_GalactoseBindingLectin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4218889). assertion_content_comment('tOboGo_GalactoseBinding',s("Interacting","selectively","and","non-covalently","with","the","aldohexose","galactose","(","galacto-hexose",")",",","a","common","constituent","of","many","oligo-","and","polysaccharides","."),4218864). assertion_content_comment('tOboGo_GalactoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","galactose",",","the","aldohexose","galacto-hexose","."),4348949). assertion_content_comment('tOboGo_GalactoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galactose",",","the","aldohexose","galacto-hexose","."),4239947). assertion_content_comment('tOboGo_GalactoseGlucoseMethylgalactosidePorterActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4289655). assertion_content_comment('tOboGo_GalactoseGlucoseUniporterActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","galactose","or","glucose","(","out",")","=","galactose","or","glucose","(","in",")"),4296617). assertion_content_comment('tOboGo_GalactoseHomeostasis',s("A","homeostatic","process","involved","in","the","maintenance","of","an","internal","steady","state","of","galactose","within","an","organism","or","cell","."),4340568). assertion_content_comment('tOboGo_Galactose_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","galactose","(","out",")","+","H","+","(","out",")","=","galactose","(","in",")","+","H","+","(","in",")"),4292840). assertion_content_comment('tOboGo_GalactoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactose",",","the","aldohexose","galacto-hexose",".","D-galactose","is","widely","distributed","in","combined","form","in","plants",",","animals","and","microorganisms","as","a","constituent","of","oligo-","and","polysaccharides",";","it","also","occurs","in","galactolipids","and","as","its","glucoside","in","lactose","and","melibiose","."),4225217). assertion_content_comment('tOboGo_GalactoseOxidaseActivity',s("Catalysis","of","the","reaction",":","D-galactose","+","O2","=","D-galacto-hexodialdose","+","hydrogen","peroxide","."),4299735). assertion_content_comment('tOboGo_Galactose_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","galactose","(","out",")","+","Na","+","(","out",")","=","glucose","(","in",")","+","Na","+","(","in",")"),4295884). assertion_content_comment('tOboGo_GalactoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","galactose","from","one","side","of","the","membrane","to","the","other",".","D-galactose","is","widely","distributed","in","combined","form","in","plants",",","animals","and","microorganisms","as","a","constituent","of","oligo-","and","polysaccharides",";","it","also","occurs","in","galactolipids","and","as","its","glucoside","in","lactose","and","melibiose","."),4216498). assertion_content_comment('tOboGo_GalactoseTransport',s("The","directed","movement","of","galactose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","D-galactose","is","widely","distributed","in","combined","form","in","plants",",","animals","and","microorganisms","as","a","constituent","of","oligo-","and","polysaccharides",";","it","also","occurs","in","galactolipids","and","as","its","glucoside","in","lactose","and","melibiose","."),4291102). assertion_content_comment('tOboGo_GalactoseUniporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","galactose","(","out",")","=","galactose","(","in",")"),4275547). assertion_content_comment('tOboGo_GalactosidaseActivity',s("Catalysis","of","the","hydrolysis","of","galactosyl","compounds",",","substances","containing","a","group","derived","from","a","cyclic","form","of","galactose","or","a","galactose","derivative","."),4204553). assertion_content_comment('tOboGo_GalactosideBinding',s("Interacting","selectively","and","non-covalently","with","any","glycoside","in","which","the","sugar","group","is","galactose","."),4301901). assertion_content_comment('tOboGo_GalactosylceramidaseActivity',s("Catalysis","of","the","reaction",":","D-galactosyl-N-acylsphingosine","+","H2O","=","D-galactose","+","N-acylsphingosine","."),4208337). assertion_content_comment('tOboGo_GalactosylceramideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","galactosylceramides",",","any","compound","formed","by","the","replacement","of","the","glycosidic","hydroxyl","group","of","a","cyclic","form","of","galactose","by","a","ceramide","group","."),4230807). assertion_content_comment('tOboGo_GalactosylceramideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galactosylceramides",",","any","compound","formed","by","the","replacement","of","the","glycosidic","hydroxyl","group","of","a","cyclic","form","of","galactose","by","a","ceramide","group","."),4230996). assertion_content_comment('tOboGo_GalactosylceramideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galactosylceramides",",","any","compound","formed","by","the","replacement","of","the","glycosidic","hydroxyl","group","of","a","cyclic","form","of","galactose","by","a","ceramide","group","."),4230778). assertion_content_comment('tOboGo_GalactosylceramideSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","a","galactosylceramide","=","adenosine","3","'",",","5","'","-bisphosphate","+","a","galactosylceramidesulfate","."),4383176). assertion_content_comment('tOboGo_GalactosylgalactosylglucosylceramidaseActivity',s("Catalysis","of","the","reaction",":","D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine","+","H2O","=","lactosyl-N-acylsphingosine","+","D-galactose","."),4268211). assertion_content_comment('tOboGo_GalactosyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","galactosyl","group","to","an","acceptor","molecule",",","typically","another","carbohydrate","or","a","lipid","."),4184673). assertion_content_comment('tOboGo_GalacturonanBinding',s("Interacting","selectively","and","non-covalently","with","any","simple","or","complex","galacturonan",".","Galacturonan","is","any","glycan","composed","solely","of","galacturonic","acid","residues",",","a","specific","type","of","glycuronan",",","and","a","constituent","of","some","pectins","."),4384488). assertion_content_comment('tOboGo_GalacturonanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galacturonan",",","a","pectin","polymer","containing","a","backbone","of","alpha-","(","1-","&","gt",";","4",")","-linked","D-galacturonic","acid","residues","."),4332169). assertion_content_comment('tOboGo_GalacturonateBinding',s("Interacting","selectively","and","non-covalently","with","any","galacturonate",".","Galacturonate","is","the","anion","of","galacturonic","acid",",","the","uronic","acid","formally","derived","from","galactose","by","oxidation","of","the","hydroxymethylene","group","at","C-6","to","a","carboxyl","group","."),4384499). assertion_content_comment('tOboGo_GalacturonateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","galacturonate",",","the","anion","of","galacturonic","acid","."),4339346). assertion_content_comment('tOboGo_GalacturonateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","galacturonate",",","the","anion","of","galacturonic","acid","."),4244515). assertion_content_comment('tOboGo_GalacturonateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","galacturonate",",","the","anion","of","galacturonic","acid",",","the","uronic","acid","formally","derived","from","galactose","by","oxidation","of","the","hydroxymethylene","group","at","C-6","to","a","carboxyl","group","."),4243152). assertion_content_comment('tOboGo_GalacturonateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","galacturonate","from","one","side","of","the","membrane","to","the","other",".","Galacturonate","is","the","uronic","acid","formally","derived","from","galactose","by","oxidation","of","the","hydroxymethylene","group","at","C-6","to","a","carboxyl","group","."),4293404). assertion_content_comment('tOboGo_GalacturonateTransport',s("The","directed","movement","of","galacturonate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290753). assertion_content_comment('tOboGo_GalacturonokinaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-galacturonate","+","ATP","=","1-phospho-alpha-D-galacturonate","+","ADP","+","2","H","(","+",")"),4378134). assertion_content_comment('tOboGo_GalaninReceptorActivity',s("Combining","with","galanin","to","initiate","a","change","in","cell","activity","."),4198190). assertion_content_comment('tOboGo_GalaninReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","galanin","receptor","."),4322685). assertion_content_comment('tOboGo_Galectin',s("OBSOLETE",".","A","lectin","that","exhibits","calcium","independent","binding","of","beta-galactoside","sugars","."),4361449). assertion_content_comment('tOboGo_GallateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","gallate",",","the","anion","of","gallic","acid","(","3",",","4",",","5-trihydroxybenzoic","acid",")"),4353332). assertion_content_comment('tOboGo_GallateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","gallate",",","the","anion","of","gallic","acid","(","3",",","4",",","5-trihydroxybenzoic","acid",")"),4239243). assertion_content_comment('tOboGo_GallateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","gallate","+","H","(","+",")","=","CO","(","2",")","+","pyrogallol","."),4274133). assertion_content_comment('tOboGo_GallateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","gallate",",","the","anion","of","gallic","acid","(","3",",","4",",","5-trihydroxybenzoic","acid",")","The","esters","and","polyesters","are","widely","distributed","in","angiosperms","."),4239236). assertion_content_comment('tOboGo_GallBladderDevelopment',s("The","progression","of","the","gall","bladder","over","time",",","from","its","initial","formation","to","the","mature","structure",".","The","gall","bladder","is","a","cavitated","organ","that","stores","bile","."),4113221). assertion_content_comment('tOboGo_GallstoneFormation',s("OBSOLETE",".","The","formation","of","gallstones",",","hard",",","crystal-like","accretions","of","cholesterol","and","bile","pigments","which","develop","when","bile","contains","too","much","cholesterol","and","not","enough","bile","."),4300473). assertion_content_comment('tOboGo_GameteGeneration',s("The","generation","and","maintenance","of","gametes","in","a","multicellular","organism",".","A","gamete","is","a","haploid","reproductive","cell","."),3980952). assertion_content_comment('tOboGo_GametophyteDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","gametophyte","over","time",",","from","its","formation","to","the","mature","structure",".","The","gametophyte","is","the","gamete-producing","individual","or","phase","in","the","life","cycle","having","alternation","of","generations",".","An","example","of","this","process","is","found","in","Arabidopsis","thaliana","."),4022821). assertion_content_comment('tOboGo_GammaDNAPolymeraseComplex',s("A","DNA","polymerase","complex","consisting","of","a","large","subunit",",","responsible","for","the","catalytic","activities",",","and","a","small","accessory","subunit",".","Functions","in","the","replication","and","repair","of","mitochondrial","DNA","."),4007781). assertion_content_comment('tOboGo_GanglionMotherCellFateDetermination',s("The","cell","fate","determination","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","ganglion","mother","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4234714). assertion_content_comment('tOboGo_GangliosideBinding',s("Interacting","selectively","and","non-covalently","with","a","ganglioside",",","a","ceramide","oligosaccharide","carrying","in","addition","to","other","sugar","residues",",","one","or","more","sialic","acid","residues","."),4379270). assertion_content_comment('tOboGo_GangliosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ceramide","oligosaccharides","carrying","in","addition","to","other","sugar","residues",",","one","or","more","sialic","acid","residues","."),4336680). assertion_content_comment('tOboGo_GangliosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ganglioside",",","a","ceramide","oligosaccharide","carrying",",","in","addition","to","other","sugar","residues",",","one","or","more","sialic","residues","."),4231022). assertion_content_comment('tOboGo_GangliosideGalactosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-galactose","+","N-acetyl-D-galactosaminyl-","(","N-acetylneuraminyl",")","-D-galactosyl-1",",","4-beta-D-glucosyl-N-acylsphingosine","=","UDP","+","D-galactosyl-1",",","3-beta-N-acetyl-D-galactosaminyl-","(","N-acetylneuraminyl",")","-D-galactosyl-D-glucosyl-N-acylsphingosine","."),4378113). assertion_content_comment('tOboGo_GangliosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ceramide","oligosaccharides","carrying","in","addition","to","other","sugar","residues",",","one","or","more","sialic","acid","residues","."),4231018). assertion_content_comment('tOboGo_GapJunctionAssembly',s("Assembly","of","gap","junctions",",","which","are","found","in","most","animal","tissues",",","and","serve","as","direct","connections","between","the","cytoplasms","of","adjacent","cells",".","They","provide","open","channels","through","the","plasma","membrane",",","allowing","ions","and","small","molecules","(","less","than","approximately","a","thousand","daltons",")","to","diffuse","freely","between","neighboring","cells",",","but","preventing","the","passage","of","proteins","and","nucleic","acids","."),4303534). assertion_content_comment('tOboGo_GapJunctionChannelActivity',s("A","wide","pore","channel","activity","that","enables","a","direct","cytoplasmic","connection","from","one","cell","to","an","adjacent","cell",".","The","gap","junction","can","pass","large","solutes","as","well","as","electrical","signals","between","cells",".","Gap","junctions","consist","of","two","gap","junction","hemi-channels",",","or","connexons",",","one","contributed","by","each","membrane","through","which","the","gap","junction","passes","."),4107469). assertion_content_comment('tOboGo_GapJunction',s("A","cell-cell","junction","that","is","composed","of","an","array","of","small","channels","that","permit","small","molecules","to","pass","from","one","cell","to","another",".","At","gap","junctions",",","the","membranes","of","two","adjacent","cells","are","separated","by","a","uniform","narrow","gap","of","about","2-4","nm","that","is","spanned","by","channel-forming","proteins","called","connexins",",","which","form","hexagonal","tubes","called","connexons","."),4008174). assertion_content_comment('tOboGo_GarlandCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","garland","cell",",","a","small","group","of","nephrocytes","which","take","up","waste","materials","from","the","hemolymph","by","endocytosis","."),4018475). assertion_content_comment('tOboGo_GarlandNephrocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","structural","and/or","functional","features","of","a","garland","nephrocyte",".","A","garland","nephrocyte","is","an","insect","renal","cell","that","filters","hemolymph","and","forms","a","ring","with","other","garland","nephrocytes","around","the","esophagus",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","and","its","subsequent","development","to","the","mature","state","."),4261638). assertion_content_comment('tOboGo_GARPComplex',s("A","quatrefoil","tethering","complex","required","for","retrograde","traffic","from","the","early","endosome","back","to","the","late","Golgi","and","biogenesis","of","cytoplasmic","vesicles","."),3979474). assertion_content_comment('tOboGo_GasHomeostasis',s("A","homeostatic","process","involved","in","the","maintenance","of","an","internal","steady","state","of","a","gas","within","an","organism","or","cell","."),4082509). assertion_content_comment('tOboGo_GasTransport',s("The","directed","movement","of","substances","that","are","gaseous","in","normal","living","conditions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4289926). assertion_content_comment('tOboGo_GastricAcidSecretion',s("The","regulated","release","of","gastric","acid","(","hydrochloric","acid",")","by","parietal","or","oxyntic","cells","during","digestion","."),4117678). assertion_content_comment('tOboGo_GastricEmptying',s("The","process","in","which","the","liquid","and","liquid-suspended","solid","contents","of","the","stomach","exit","through","the","pylorus","into","the","duodenum","."),4376847). assertion_content_comment('tOboGo_GastricInhibitoryPeptideReceptorActivity',s("Combining","with","gastric","inhibitory","peptide","to","initiate","a","change","in","cell","activity","."),4305199). assertion_content_comment('tOboGo_GastricInhibitoryPolypeptideReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","gastric","inhibitory","polypeptide","receptor","."),4322866). assertion_content_comment('tOboGo_GastricMotility',s("The","spontaneous","peristaltic","movements","of","the","stomach","that","aid","in","digestion",",","moving","food","through","the","stomach","and","out","through","the","pyloric","sphincter","into","the","duodenum","."),4376845). assertion_content_comment('tOboGo_GastrinReceptorActivity',s("Combining","with","gastrin","to","initiate","a","change","in","cell","activity","."),4297193). assertion_content_comment('tOboGo_GastropyloricReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383853). assertion_content_comment('tOboGo_GastrulationInvolvingGermBandExtension',s("A","complex","and","coordinated","series","of","cellular","movements",",","including","germ","band","extension",",","that","occurs","at","the","end","of","cleavage","during","embryonic","development",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4019347). assertion_content_comment('tOboGo_Gastrulation',s("A","complex","and","coordinated","series","of","cellular","movements","that","occurs","at","the","end","of","cleavage","during","embryonic","development","of","most","animals",".","The","details","of","gastrulation","vary","from","species","to","species",",","but","usually","result","in","the","formation","of","the","three","primary","germ","layers",",","ectoderm",",","mesoderm","and","endoderm","."),3982045). assertion_content_comment('tOboGo_GastrulationWithMouthFormingFirst',s("A","gastrulation","process","in","which","the","initial","invagination","becomes","the","mouth","and","the","anus","forms","second","."),4019344). assertion_content_comment('tOboGo_GastrulationWithMouthFormingSecond',s("A","gastrulation","process","in","which","the","initial","invagination","becomes","the","anus","and","the","mouth","forms","second","."),4109478). assertion_content_comment('tOboGo_GasVesicleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","gas","vesicle",".","A","gas","vesicle","is","a","hollow","structure","made","of","protein",",","which","usually","has","the","form","of","a","cylindrical","tube","closed","by","conical","end","caps","."),4319492). assertion_content_comment('tOboGo_GasVesicle',s("A","hollow","structure","made","of","protein",",","which","usually","has","the","form","of","a","cylindrical","tube","closed","by","conical","end","caps",".","By","regulating","their","relative","gas","vesicle","content","aquatic","microbes","are","able","to","perform","vertical","migrations","."),4065387). assertion_content_comment('tOboGo_GasVesicleShell',s("The","proteinaceous","structure","surrounding","a","gas","vesicle","."),4065397). assertion_content_comment('tOboGo_GatedChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","solute","by","a","channel","that","opens","in","response","to","a","specific","stimulus","."),4158390). assertion_content_comment('tOboGo_GBDDomainBinding',s("Interacting","selectively","and","non-covalently","with","the","GTPase","protein","binding","domain","(","GDB",")","domain","of","a","protein",".","The","GBD","is","a","short","motif",",","including","a","minimum","region","of","16","amino","acids",",","identified","in","proteins","that","bind","to","small","GTPases","such","as","Cdc42","and","Rac","."),4334984). assertion_content_comment('tOboGo_GCH1Complex',s("A","protein","complex","that","possesses","GTP","cyclohydrolase","I","activity",".","In","E",".","coli","and","human",",","the","complex","is","a","homodecamer",",","and","monomers","are","catalytically","inactive","."),4353710). assertion_content_comment('tOboGo_GDPBinding',s("Interacting","selectively","and","non-covalently","with","GDP",",","guanosine","5","'","-diphosphate","."),4236478). assertion_content_comment('tOboGo_GDPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","GDP",",","guanosine","5","'","-diphosphate","."),4356238). assertion_content_comment('tOboGo_GDPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","GDP",",","guanosine","5","'","-diphosphate","."),4356224). assertion_content_comment('tOboGo_GDPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","GDP",",","guanosine","5","'","-diphosphate","."),4356221). assertion_content_comment('tOboGo_GeissoschizineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","geissoschizine","+","NADP","(","+",")","=","4",",","21-dehydrogeissoschizine","+","H","(","+",")","+","NADPH","."),4378090). assertion_content_comment('tOboGo_GelatinaseAActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","gelatin","type","I","and","collagen","types","IV",",","V",",","VII",",","X",".","Cleaves","the","collagen-like","sequence","Pro-Gln-Gly-Ile-Ala-Gly-Gln","at","the","Gly-Ile","bond","."),4209883). assertion_content_comment('tOboGo_GelatinaseBActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","gelatin","types","I","and","V","and","collagen","types","IV","and","V","."),4209860). assertion_content_comment('tOboGo_GeneConversionOfImmunoglobulinGenesInvolvedInImmuneResponse',s("The","somatic","process","in","which","immunoglobulin","genes","are","diversified","through","the","mechanism","of","gene","conversion","following","the","induction","of","and","contributing","to","an","immune","response","."),4377138). assertion_content_comment('tOboGo_GeneConversionOfImmunoglobulinGenes',s("The","somatic","process","in","which","immunoglobulin","genes","are","diversified","through","the","mechanism","of","gene","conversion","."),4377134). assertion_content_comment('tOboGo_GeneExpression',s("The","process","in","which","a","gene","'","s","sequence","is","converted","into","a","mature","gene","product","or","products","(","proteins","or","RNA",")","This","includes","the","production","of","an","RNA","transcript","as","well","as","any","processing","to","produce","a","mature","RNA","product","or","an","mRNA","(","for","protein-coding","genes",")","and","the","translation","of","that","mRNA","into","protein",".","Some","protein","processing","events","may","be","included","when","they","are","required","to","form","an","active","form","of","a","product","from","an","inactive","precursor","form","."),3970849). assertion_content_comment('tOboGo_GeneLooping',s("The","formation","and","maintenance","of","DNA","loops","that","juxtapose","sequentially","separated","regions","of","RNA","polymerase","II-transcribed","genes","."),4155642). assertion_content_comment('tOboGo_Gene_Ontology',s("OBSOLETE",".","A","controlled","vocabulary","that","can","be","applied","to","all","organisms","even","as","knowledge","of","gene","and","protein","roles","in","cells","is","accumulating","and","changing",".","GO","provides","three","structured","networks","of","defined","terms","to","describe","gene","product","attributes","."),4193426). assertion_content_comment('tOboGo_GeneralAdaptationSyndromeBehavioralProcess',s("The","set","of","behavioral","processes","that","occur","as","part","of","the","general","adaptation","syndrome",",","the","response","of","the","body","to","a","strong",",","stressful","stimulus","."),4122564). assertion_content_comment('tOboGo_GeneralAdaptationSyndrome',s("General","adaptation","syndrome","is","the","set","of","changes","in","various","organ","systems","of","the","body",",","especially","the","pituitary-endocrine","system",",","in","response","to","a","wide","range","of","strong","external","stimuli",",","both","physiological","and","psychological",".","It","is","described","as","having","three","stages",":","alarm","reaction",",","where","the","body","detects","the","external","stimulus",";","adaptation",",","where","the","body","engages","defensive","countermeasures","against","the","stressor",";","and","exhaustion",",","where","the","body","begins","to","run","out","of","defenses","."),4122550). assertion_content_comment('tOboGo_GeneralAminoAcidPermeaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4215695). assertion_content_comment('tOboGo_GeneralRNAPolymeraseIITranscriptionFactorActivity',s("Any","function","that","supports","basal","(","unregulated",")","transcription","of","genes","by","core","RNA","polymerase","II",".","Five","general","transcription","factors","are","necessary","and","sufficient","for","such","basal","transcription","in","yeast",":","TFIIB",",","TFIID",",","TFIIE",",","TFIIF",",","TFIIH","and","TATA-binding","protein","(","TBF",")"),4303715). assertion_content_comment('tOboGo_GeneralTranscriptionalRepressorActivity',s("Any","activity","that","stops","or","downregulates","transcription","of","genes","globally",",","and","is","not","specific","to","a","particular","gene","or","gene","set","."),4305491). assertion_content_comment('tOboGo_GeneralTranscriptionFromRNAPolymeraseIIPromoter',s("The","basal",",","non-specifically","regulated","synthesis","of","RNA","from","a","DNA","template","by","RNA","polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter",".","Mediated","by","core","RNA","polymerase","II","and","a","set","of","general","transcription","factors",";","in","Saccharomyces","five","transcription","factors","are","necessary","and","sufficient","for","such","basal","transcription","."),4331791). assertion_content_comment('tOboGo_GenerationOfCatalyticSpliceosomeForFirstTransesterificationStep',s("Formation","of","a","catalytic","spliceosome","complex","ready","to","perform","the","first","splicing","reaction",".","This","occurs","by","an","ATP-dependent","conformational","change","of","the","pre-catalytic","spliceosome","."),3975414). 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assertion_content_comment('tOboGo_GlialCellGrowth',s("Growth","of","glial","cells",",","non-neuronal","cells","that","provide","support","and","nutrition",",","maintain","homeostasis",",","form","myelin",",","and","participate","in","signal","transmission","in","the","nervous","system","."),4081572). assertion_content_comment('tOboGo_GlialCellMigrationInAnteriorLateralLineNerve',s("The","movement","of","a","glial","cell","along","the","axons","in","the","anterior","lateral","line","nerve","."),4106158). assertion_content_comment('tOboGo_GlialCellMigrationInPosteriorLateralLineNerve',s("The","movement","of","a","glial","cell","along","the","axons","in","the","posterior","lateral","line","nerve","."),4106107). assertion_content_comment('tOboGo_GlialCellMigration',s("The","orderly","movement","of","a","glial","cell",",","non-neuronal","cells","that","provide","support","and","nutrition",",","maintain","homeostasis",",","form","myelin",",","and","participate","in","signal","transmission","in","the","nervous","system","."),4020587). assertion_content_comment('tOboGo_GlialCellProliferation',s("The","multiplication","or","reproduction","of","glial","cells","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","Glial","cells","exist","throughout","the","nervous","system",",","and","include","Schwann","cells",",","astrocytes",",","and","oligodendrocytes","among","others","."),4028580). assertion_content_comment('tOboGo_GlialFibrillaryAcidicProtein',s("OBSOLETE",".","Glial","fibrillary","acidic","protein","forms","filaments","in","the","glial","cells","that","surround","neurons","and","in","astrocytes","."),4299919). assertion_content_comment('tOboGo_GlioblastDivision',s("The","process","resulting","in","the","physical","partitioning","and","separation","of","a","glioblast","into","daughter","cells","."),4050945). assertion_content_comment('tOboGo_Gliogenesis',s("The","process","that","results","in","the","generation","of","glial","cells",".","This","includes","the","production","of","glial","progenitors","and","their","differentiation","into","mature","glia","."),4004801). assertion_content_comment('tOboGo_Globin',s("OBSOLETE",".","The","colorless","and","basic","protein","moiety","of","hemoglobin","and","myoglobins","."),4361482). assertion_content_comment('tOboGo_GloboseNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","globose","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042565). assertion_content_comment('tOboGo_GlobosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","ceramide","with","a","core","structure","of","GalNAc-beta-","(","1",",","3",")","-Gal-alpha","(","1",",","4",")","Glc","(","I",")"),4336653). assertion_content_comment('tOboGo_GlobosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","globosides",",","globotetraosylceramides",",","ceramides","containing","a","core","structure","of","GalNAc-beta-","(","1",",","3",")","-Gal-alpha","(","1",",","4",")","Glc","(","I",")","Globosides","are","the","major","neutral","glycosphingolipid","in","normal","kidneys","and","erythrocytes","."),4336649). assertion_content_comment('tOboGo_GlobusPallidusDevelopment',s("The","progression","of","the","globus","pallidus","over","time","from","its","initial","formation","until","its","mature","state",".","The","globus","pallidus","is","one","of","the","basal","ganglia","involved","with","control","of","voluntary","movement","in","the","brain","."),4049514). assertion_content_comment('tOboGo_GlomerularBasementMembraneDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","glomerular","basement","membrane","over","time",",","from","its","formation","to","the","mature","structure",".","The","glomerular","basement","membrane","is","the","basal","laminal","portion","of","the","glomerulus","which","performs","the","actual","filtration","."),4069933). assertion_content_comment('tOboGo_GlomerularCapillaryFormation',s("The","process","that","gives","rise","to","a","glomerular","capillary",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4123991). assertion_content_comment('tOboGo_GlomerularEndotheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","glomerular","endothelium","over","time",",","from","its","formation","to","the","mature","structure",".","The","glomerular","endothelium","is","an","epithelial","tissue","that","covers","the","internal","surfaces","of","the","glomerulus","."),4124104). assertion_content_comment('tOboGo_GlomerularEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","glomerular","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","glomerulus",";","there","are","two","types",",","glomerular","parietal","epithelial","cells","and","glomerular","visceral","epithelial","cells","."),4124791). assertion_content_comment('tOboGo_GlomerularEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","glomerular","epithelial","cell",".","Glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","glomerulus",";","there","are","two","types",",","glomerular","parietal","epithelial","cells","and","glomerular","visceral","epithelial","cells","."),4123080). assertion_content_comment('tOboGo_GlomerularEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","glomerular","epithelial","cell",".","Glomerular","epithelial","cells","are","specialized","epithelial","cells","that","form","part","of","the","glomerulus",";","there","are","two","types",",","glomerular","parietal","epithelial","cells","and","glomerular","visceral","epithelial","cells","."),4123100). assertion_content_comment('tOboGo_GlomerularEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","glomerular","epithelium","over","time",",","from","its","formation","to","the","mature","structure",".","The","glomerular","epithelium","is","an","epithelial","tissue","that","covers","the","outer","surfaces","of","the","glomerulus",".","The","glomerular","epithelium","consists","of","both","parietal","and","visceral","epithelium",".","Metanephric","glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport",".","A","metanephric","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","in","the","metanephros","."),4123078). assertion_content_comment('tOboGo_GlomerularMesangialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","glomerular","mesangial","cell","in","the","kidney","over","time",",","from","its","formation","to","the","mature","structure","."),4123001). assertion_content_comment('tOboGo_GlomerularMesangialCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","glomerular","mesangial","cells","of","the","kidney","as","it","progresses","from","its","formation","to","the","mature","state","."),4122991). assertion_content_comment('tOboGo_GlomerularMesangialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","glomerular","mesangial","cell","."),4123166). assertion_content_comment('tOboGo_GlomerularMesangialCellProliferation',s("The","multiplication","or","reproduction","of","glomerular","mesangial","cells",",","resulting","in","the","expansion","of","the","population","."),4122613). assertion_content_comment('tOboGo_GlomerularMesangiumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","glomerular","mesangium","over","time",",","from","its","formation","to","the","mature","structure",".","The","glomerular","mesangium","is","the","thin","membrane","connective","tissue","composed","of","mesangial","cells",",","which","helps","to","support","the","capillary","loops","in","a","renal","glomerulus","."),4122603). assertion_content_comment('tOboGo_GlomerularParietalEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","glomerular","parietal","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport","."),4125392). assertion_content_comment('tOboGo_GlomerularParietalEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","glomerular","parietal","epithelial","cell",".","Glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport","."),4123082). assertion_content_comment('tOboGo_GlomerularParietalEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","glomerular","parietal","epithelial","cell",".","Glomerular","parietal","epithelial","cells","are","specialized","epithelial","cells","that","form","tight","junctions","as","a","barrier","to","protein","transport",".","These","cells","may","also","give","rise","to","podocytes","."),4123103). assertion_content_comment('tOboGo_GlomerularVisceralEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","glomerular","visceral","epithelial","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","."),4125334). assertion_content_comment('tOboGo_GlomerularVisceralEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","glomerular","visceral","epithelial","cell",".","A","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","."),4123123). assertion_content_comment('tOboGo_GlomerularVisceralEpithelialCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","glomerular","visceral","epithelial","cell",".","A","glomerular","visceral","epithelial","cell","is","a","specialized","epithelial","cell","that","contains","\"","feet","\"","that","interdigitate","with","the","\"","feet","\"","of","other","glomerular","epithelial","cells","."),4123135). assertion_content_comment('tOboGo_GlomerulusDevelopment',s("The","progression","of","the","glomerulus","over","time","from","its","initial","formation","until","its","mature","state",".","The","glomerulus","is","a","capillary","tuft","which","forms","a","close","network","with","the","visceral","epithelium","(","podocytes",")","and","the","mesangium","to","form","the","filtration","barrier","and","is","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney",".","The","glomerulus","is","part","of","the","nephron","and","is","restricted","to","one","body","segment","."),4058831). assertion_content_comment('tOboGo_GlomerulusMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","glomerulus","are","generated","and","organized",".","The","glomerulus","is","a","capillary","tuft","surrounded","by","Bowman","'","s","capsule","in","nephrons","of","the","vertebrate","kidney","."),4081409). assertion_content_comment('tOboGo_GlomerulusVasculatureDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","glomerulus","vasculature","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","glomerulus","vasculature","and","ends","with","the","mature","structure",".","The","glomerulus","vasculature","is","composed","of","the","tubule","structures","that","carry","blood","or","lymph","in","the","glomerulus","."),4122600). assertion_content_comment('tOboGo_GlomerulusVasculatureMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","glomerulus","vasculature","are","generated","and","organized",".","The","glomerulus","vasculature","is","composed","of","the","tubule","structures","that","carry","blood","or","lymph","in","the","glomerulus","."),4123981). assertion_content_comment('tOboGo_GlomusDevelopment',s("The","progression","of","the","glomus","over","time","from","its","initial","formation","until","its","mature","state",".","The","glomus","forms","from","the","splanchnic","intermediate","mesoderm","and","is","the","vascularized","filtration","unit",",","filtering","the","blood","before","it","enters","the","tubules",".","The","glomus","is","external","to","the","nephron","and","extends","over","more","than","one","body","segment","."),4125802). assertion_content_comment('tOboGo_GlossopharyngealNerveDevelopment',s("Various","sensory","and","motor","branches","of","the","glossopharyngeal","nerve","supply","nerve","connections","to","the","pharynx","and","back","of","the","tongue",".","The","branchial","motor","component","contains","motor","fibers","that","innervate","muscles","that","elevate","the","pharynx","and","larynx",",","and","the","tympanic","branch","supplies","parasympathetic","fibers","to","the","otic","ganglion","."),4044246). assertion_content_comment('tOboGo_GlossopharyngealNerveFormation',s("The","process","that","gives","rise","to","the","glossopharyngeal","nerve",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","Various","sensory","and","motor","branches","of","the","glossopharyngeal","nerve","supply","nerve","connections","to","the","pharynx","and","back","of","the","tongue",".","The","branchial","motor","component","contains","motor","fibers","that","innervate","muscles","that","elevate","the","pharynx","and","larynx",",","and","the","tympanic","branch","supplies","parasympathetic","fibers","to","the","otic","ganglion","."),4044275). assertion_content_comment('tOboGo_GlossopharyngealNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","glossopharyngeal","nerve","to","attain","its","fully","functional","state",".","Various","sensory","and","motor","branches","of","the","glossopharyngeal","nerve","supply","nerve","connections","to","the","pharynx","and","back","of","the","tongue",".","The","branchial","motor","component","contains","motor","fibers","that","innervate","muscles","that","elevate","the","pharynx","and","larynx",",","and","the","tympanic","branch","supplies","parasympathetic","fibers","to","the","otic","ganglion","."),4044846). assertion_content_comment('tOboGo_GlossopharyngealNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","glossopharyngeal","nerve","is","generated","and","organized",".","Various","sensory","and","motor","branches","of","the","glossopharyngeal","nerve","supply","nerve","connections","to","the","pharynx","and","back","of","the","tongue",".","The","branchial","motor","component","contains","motor","fibers","that","innervate","muscles","that","elevate","the","pharynx","and","larynx",",","and","the","tympanic","branch","supplies","parasympathetic","fibers","to","the","otic","ganglion","."),4044251). assertion_content_comment('tOboGo_GlossopharyngealNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","glossopharyngeal","nerve",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","Various","sensory","and","motor","branches","of","the","glossopharyngeal","nerve","supply","nerve","connections","to","the","pharynx","and","back","of","the","tongue",".","The","branchial","motor","component","contains","motor","fibers","that","innervate","muscles","that","elevate","the","pharynx","and","larynx",",","and","the","tympanic","branch","supplies","parasympathetic","fibers","to","the","otic","ganglion","."),4044263). assertion_content_comment('tOboGo_GlucagonReceptorActivity',s("Combining","with","glucagon","to","initiate","a","change","in","cell","activity","."),4198181). assertion_content_comment('tOboGo_GlucagonReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","glucagon","receptor","."),4322886). assertion_content_comment('tOboGo_GlucagonSecretion',s("The","regulated","release","of","glucagon","from","secretory","granules","in","the","A","(","alpha",")","cells","of","the","pancreas","(","islets","of","Langerhans",")"),4132993). assertion_content_comment('tOboGo_GlucanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucans",",","polysaccharides","consisting","only","of","glucose","residues","."),4009098). assertion_content_comment('tOboGo_GlucanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucans",",","polysaccharides","consisting","only","of","glucose","residues","."),4008837). assertion_content_comment('tOboGo_GlucanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucans",",","polysaccharides","consisting","only","of","glucose","residues","."),4008717). assertion_content_comment('tOboGo_GlucanosyltransferaseActivity',s("Catalysis","of","the","splitting","and","linkage","of","glucan","molecules",",","resulting","in","glucan","chain","elongation","."),4313856). assertion_content_comment('tOboGo_GlucarateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucarate",",","the","anion","of","glucaric","acid","."),4239371). assertion_content_comment('tOboGo_GlucarateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucarate",",","the","anion","of","glucaric","acid","."),4239401). assertion_content_comment('tOboGo_GlucarateDehydrataseActivity',s("Catalysis","of","the","reaction",":","D-glucarate","=","5-dehydro-4-deoxy-D-glucarate","+","H2O","."),4249656). assertion_content_comment('tOboGo_GlucarateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucarate",",","the","dianion","of","glucaric","acid",",","an","aldaric","acid","derived","from","either","glucose","or","gulose",".","There","are","two","enantiomers","L-","and","D-glucarate","."),4239343). assertion_content_comment('tOboGo_GlucocorticoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucocorticoids",",","hormonal","C21","corticosteroids","synthesized","from","cholesterol","."),4057519). assertion_content_comment('tOboGo_GlucocorticoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucocorticoids",",","hormonal","C21","corticosteroids","synthesized","from","cholesterol","."),4057409). assertion_content_comment('tOboGo_GlucocorticoidMediatedSignalingPathway',s("A","series","of","molecular","signals","mediated","by","the","detection","of","a","glucocorticoid","hormone","."),4324767). assertion_content_comment('tOboGo_GlucocorticoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucocorticoids",",","hormonal","C21","corticosteroids","synthesized","from","cholesterol",".","Glucocorticoids","act","primarily","on","carbohydrate","and","protein","metabolism",",","and","have","anti-inflammatory","effects","."),4057404). assertion_content_comment('tOboGo_GlucocorticoidReceptorActivity',s("Combining","with","a","glucocorticoid","to","initiate","a","change","in","cell","activity","."),4200063). assertion_content_comment('tOboGo_GlucocorticoidReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","glucocorticoid","receptor","."),4320493). assertion_content_comment('tOboGo_GlucocorticoidReceptorImportIntoNucleus',s("The","directed","movement","of","a","glucocorticoid","receptor","into","the","nucleus","."),3993087). assertion_content_comment('tOboGo_GlucocorticoidReceptorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","a","glucocorticoid","binding","to","its","receptor","."),3993065). assertion_content_comment('tOboGo_GlucokinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","D-glucose","=","ADP","+","D-glucose-6-phosphate","."),4207931). assertion_content_comment('tOboGo_GlucomannanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucomannan",",","a","polysaccharide","composed","of","D-glucose","and","D-mannose",".","The","mannose","units","form","the","backbone","structure","(","a","linear","main","chain",")","with","the","D-glucose","as","single","side-units","."),4332147). assertion_content_comment('tOboGo_GluconateChannelActivity',"OBSOLETE.",4295429). assertion_content_comment('tOboGo_GluconateDehydrataseActivity',s("Catalysis","of","the","reaction",":","D-gluconate","=","2-dehydro-3-deoxy-D-gluconate","+","H","(","2",")","O","."),4377082). assertion_content_comment('tOboGo_GluconateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","D-gluconate","+","NADP","+","=","dehydro-D-gluconate","+","NADPH","+","H","+"),4249677). assertion_content_comment('tOboGo_GluconateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","gluconate","from","one","side","of","the","membrane","to","the","other",".","Gluconate","is","the","aldonic","acid","derived","from","glucose","."),4290269). assertion_content_comment('tOboGo_GluconateTransmembraneTransport',s("The","directed","movement","of","gluconate","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Gluconate","is","the","aldonic","acid","derived","from","glucose","."),4083072). assertion_content_comment('tOboGo_GluconateTransport',s("The","directed","movement","of","gluconate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Gluconate","is","the","aldonic","acid","derived","from","glucose","."),4064682). assertion_content_comment('tOboGo_Gluconeogenesis',s("The","formation","of","glucose","from","noncarbohydrate","precursors",",","such","as","pyruvate",",","amino","acids","and","glycerol","."),4010488). assertion_content_comment('tOboGo_GluconokinaseActivity',s("Catalysis","of","the","reaction",":","D-gluconate","+","ATP","=","6-phospho-D-gluconate","+","ADP","+","2","H","(","+",")"),4349656). assertion_content_comment('tOboGo_GluconolactonaseActivity',s("Catalysis","of","the","reaction",":","D-glucono-1",",","5-lactone","+","H2O","=","D-gluconate","."),4207894). assertion_content_comment('tOboGo_GlucosamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosamine","(","2-amino-2-deoxyglucopyranose",")",",","an","aminodeoxysugar","that","occurs","in","combined","form","in","chitin","."),4084245). 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assertion_content_comment('tOboGo_GlucoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucose",",","the","aldohexose","gluco-hexose","."),4010423). assertion_content_comment('tOboGo_GlucoseCatabolicProcessToButanediol',s("The","anaerobic","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucose","into","2",",","3-butanediol","and","other","substances",";","effected","by","some","members","of","the","Enterobacteriaceae",",","e.g",".","Enterobacter",",","Erwinia",",","Klebsiella",",","and","Serratia","."),4244333). 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assertion_content_comment('tOboGo_GlucoseMediatedSignalingPathway',s("The","process","in","which","a","change","in","the","level","of","mono-","and","disaccharide","glucose","trigger","the","expression","of","genes","controlling","metabolic","and","developmental","processes","."),4335444). assertion_content_comment('tOboGo_GlucoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucose",",","the","aldohexose","gluco-hexose",".","D-glucose","is","dextrorotatory","and","is","sometimes","known","as","dextrose",";","it","is","an","important","source","of","energy","for","living","organisms","and","is","found","free","as","well","as","combined","in","homo-","and","hetero-oligosaccharides","and","polysaccharides","."),4008982). assertion_content_comment('tOboGo_GlucoseOxidaseActivity',s("Catalysis","of","the","reaction",":","beta-D-glucose","+","O2","=","D-glucono-1",",","5-lactone","+","H2O2","."),4358806). 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assertion_content_comment('tOboGo_GlucoseUniporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","glucose","(","out",")","=","glucose","(","in",")"),4296590). assertion_content_comment('tOboGo_GlucosidaseActivity',s("Catalysis","of","the","hydrolysis","of","glucosyl","compounds",",","substances","containing","a","group","derived","from","a","cyclic","form","of","glucose","or","a","glucose","derivative","."),4182366). assertion_content_comment('tOboGo_GlucosideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","glucosides","from","one","side","of","the","membrane","to","the","other",".","Glucosides","are","glycosides","in","which","the","sugar","group","is","a","glucose","residue","."),4216524). assertion_content_comment('tOboGo_GlucosideTransport',s("The","directed","movement","of","glucosides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Glucosides","are","glycosides","in","which","the","sugar","group","is","a","glucose","residue","."),4157417). assertion_content_comment('tOboGo_GlucosinolateBiosyntheticProcessFromHomomethionine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosinolates","from","other","compounds","including","homomethionine","."),4340666). assertion_content_comment('tOboGo_GlucosinolateBiosyntheticProcessFromPhenylalanine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosinolates","from","other","compounds","including","phenylalanine","."),4340652). assertion_content_comment('tOboGo_GlucosinolateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosinolates",",","substituted","thioglucosides","found","in","rapeseed","products","and","related","cruciferae","."),4029104). assertion_content_comment('tOboGo_GlucosinolateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucosinolates",",","substituted","thioglucosides","found","in","rapeseed","products","and","related","cruciferae","."),4245580). assertion_content_comment('tOboGo_GlucosinolateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucosinolates",",","substituted","thioglucosides","found","in","rapeseed","products","and","related","cruciferae",".","They","are","metabolized","to","a","variety","of","toxic","products","which","are","most","likely","the","cause","of","hepatocytic","necrosis","in","animals","and","humans","."),4029101). assertion_content_comment('tOboGo_GlucosylceramidaseActivity',s("Catalysis","of","the","reaction",":","D-glucosyl-N-acylsphingosine","+","H2O","=","D-glucose","+","N-acylsphingosine","."),4208036). assertion_content_comment('tOboGo_GlucosylceramideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosylceramides",",","any","compound","formed","by","the","replacement","of","the","glycosidic","hydroxyl","group","of","a","cyclic","form","of","glucose","by","a","ceramide","group","."),4098342). assertion_content_comment('tOboGo_GlucosylceramideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucosylceramides",",","any","compound","formed","by","the","replacement","of","the","glycosidic","hydroxyl","group","of","a","cyclic","form","of","glucose","by","a","ceramide","group","."),4230923). assertion_content_comment('tOboGo_GlucosylceramideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucosylceramides",",","any","compound","formed","by","the","replacement","of","the","glycosidic","hydroxyl","group","of","a","cyclic","form","of","glucose","by","a","ceramide","group",".","They","are","neutral","glycolipids","containing","equimolar","amounts","of","fatty","acid",",","glucose",",","and","sphingosine","or","a","sphingosine","derivative","."),4098260). assertion_content_comment('tOboGo_GlucosylglycerolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucosylglycerol",",","alpha-D-glucopyranosyl-alpha-","(","1",",","2",")","-glycerol","."),4286463). assertion_content_comment('tOboGo_GlucosylglycerolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucosylglycerol",",","alpha-D-glucopyranosyl-alpha-","(","1",",","2",")","-glycerol","."),4286451). assertion_content_comment('tOboGo_GlucosylglycerolTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","glucosylglycerol","from","one","side","of","the","membrane","to","the","other",".","A","glucosylglycerol","is","an","alpha-D-glucopyranosyl-alpha-","(","1",",","2",")","-glycerol","."),4286476). assertion_content_comment('tOboGo_GlucosylglycerolTransport',s("The","directed","movement","of","glucosylglycerol",",","alpha-D-glucopyranosyl-alpha-","(","1",",","2",")","-glycerol",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4286486). assertion_content_comment('tOboGo_GlucosyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","glucosyl","group","to","an","acceptor","molecule",",","typically","another","carbohydrate","or","a","lipid","."),4181866). assertion_content_comment('tOboGo_GlucuronanLyaseActivity',s("Catalysis","of","the","eliminative","cleavage","of","(","1-","&","gt",";","4",")","-beta-D-glucuronans","to","give","oligosaccharides","with","4-deoxy-beta-D-gluc-4-enuronosyl","groups","at","their","non-reducing","ends",".","Complete","degradation","of","glucuronans","results","in","the","formation","of","tetrasaccharides","."),4345276). 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assertion_content_comment('tOboGo_GlucuronateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","glucuronate","from","one","side","of","the","membrane","to","the","other",".","Glucuronate","is","the","uronic","acid","formally","derived","from","glucose","by","oxidation","of","the","hydroxymethylene","group","at","C-6","to","a","carboxyl","group","."),4297325). assertion_content_comment('tOboGo_GlucuronateTransport',s("The","directed","movement","of","glucuronate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290762). assertion_content_comment('tOboGo_Glucuronide_MonovalentCationSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","glucuronide","(","out",")","+","monovalent","cation","(","out",")","=","glucuronide","(","in",")","+","monovalent","cation","(","in",")"),4292499). assertion_content_comment('tOboGo_GlucuronoarabinoxylanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","xylan",",","a","polymer","containing","a","beta-","(","1-","&","gt",";","4",")","-linked","D-xylose","backbone","decorated","with","glucuronic","acid","and","arabinose","side","units","."),4333529). assertion_content_comment('tOboGo_GlucuronokinaseActivity',s("Catalysis","of","the","reaction",":","D-glucuronate","+","ATP","=","1-phospho-alpha-D-glucuronate","+","ADP","+","2","H","(","+",")"),4377233). assertion_content_comment('tOboGo_GlucuronolactoneReductaseActivity',s("Catalysis","of","the","reaction",":","L-gulono-1",",","4-lactone","+","NADP","(","+",")","=","D-glucurono-3",",","6-lactone","+","H","(","+",")","+","NADPH","."),4377209). assertion_content_comment('tOboGo_GlucuronosideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glucuronosides",",","compound","composed","of","a","hydroxy","compound","linked","to","a","glucuronate","residue","."),4239415). assertion_content_comment('tOboGo_GlucuronosideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glucuronosides",",","compound","composed","of","a","hydroxy","compound","linked","to","a","glucuronate","residue","."),4239315). assertion_content_comment('tOboGo_GlucuronosideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glucuronosides",",","any","compound","formed","by","combination","in","glycosidic","linkage","of","a","hydroxy","compound","with","the","anomeric","carbon","atom","of","a","glucuronate","."),4239309). assertion_content_comment('tOboGo_GlucuronosideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","glucuronosides","from","one","side","of","the","membrane","to","the","other",".","Glucuronosides","are","any","compound","formed","by","combination","of","glycosidic","linkage","of","a","hydroxy","compound","(","e.g",".","an","alcohol","or","a","saccharide",")","with","the","anomeric","carbon","atom","of","glucuronate","."),4292495). assertion_content_comment('tOboGo_GlucuronosideTransport',s("The","directed","movement","of","glucuronosides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Glucuronosides","are","any","compound","formed","by","combination","of","glycosidic","linkage","of","a","hydroxy","compound","(","e.g",".","an","alcohol","or","a","saccharide",")","with","the","anomeric","carbon","atom","of","glucuronate","."),4291252). assertion_content_comment('tOboGo_GlucuronosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-glucuronate","+","acceptor","=","UDP","+","acceptor","beta-D-glucuronoside","."),4181739). 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assertion_content_comment('tOboGo_GlutamateAspartatePorterActivity',s("OBSOLETE",".","Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","polar","amino","acid","(","out",")","=","ADP","+","phosphate","+","polar","amino","acid","(","in",")"),4289863). assertion_content_comment('tOboGo_GlutamateAspartate_SodiumSymporterActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","(","glutamate","or","aspartate",")","(","out",")","+","Na","+","(","out",")","=","(","glutamate","or","aspartate",")","(","in",")","+","Na","+","(","in",")"),4295874). assertion_content_comment('tOboGo_GlutamateBinding',s("Interacting","selectively","and","non-covalently","with","glutamate",",","the","anion","of","2-aminopentanedioic","acid","."),4254807). 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assertion_content_comment('tOboGo_GlutamateCatabolicProcessToFumarateUsingGlutamateSynthaseNADPH',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","into","fumarate","of","glutamate",",","catalyzed","by","the","enzyme","glutamate","synthase","(","NADPH",")","(","EC",":","1.4.1.13",")"),4241451). assertion_content_comment('tOboGo_GlutamateCatabolicProcessToFumarateUsingGlutaminase',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","into","fumarate","of","glutamate",",","catalyzed","by","the","enzyme","glutaminase","(","EC",":","3.5.1.2",")"),4241439). assertion_content_comment('tOboGo_GlutamateCatabolicProcessToOrnithine',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glutamate","into","other","compounds",",","including","ornithine","."),4242979). 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assertion_content_comment('tOboGo_GlutamateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-glutamate","+","H2O","+","NAD","+","=","2-oxoglutarate","+","NH3","+","NADH","+","H","+"),4207645). assertion_content_comment('tOboGo_GlutamateDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","L-glutamate","+","H2O","+","NADP","+","=","2-oxoglutarate","+","NH3","+","NADPH","+","H","+"),4207689). assertion_content_comment('tOboGo_GlutamateFormimidoyltransferaseActivity',s("Catalysis","of","the","reaction",":","5-formimidoyltetrahydrofolate","+","L-glutamate","=","tetrahydrofolate","+","N-formimidoyl-L-glutamate","."),4310234). assertion_content_comment('tOboGo_GlutamateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glutamate",",","the","anion","of","2-aminopentanedioic","acid","."),4141173). 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assertion_content_comment('tOboGo_Glutamate_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","glutamate","(","out",")","+","Na","+","(","out",")","=","glutamate","(","in",")","+","Na","+","(","in",")"),4292589). assertion_content_comment('tOboGo_GlutamateSynthaseActivityNADHOrNADPHAsAcceptor',s("Catalysis","of","the","reaction",":","2","L-glutamate","+","NAD","(","P",")","+","=","L-glutamine","+","2-oxoglutarate","+","NAD","(","P",")","H","+","H","+"),4207777). assertion_content_comment('tOboGo_GlutamateSynthaseActivity',s("Catalysis","of","the","formation","of","L-glutamine","and","2-oxoglutarate","from","L-glutamate",",","using","NADH",",","NADPH","or","ferredoxin","as","hydrogen","acceptors","."),4207774). assertion_content_comment('tOboGo_GlutamateSynthaseComplexNADH',s("A","protein","complex","that","in","yeast","consists","of","a","large","and","a","small","subunit",".","Possesses","glutamate","synthase","(","NADH",")","activity","."),4093375). assertion_content_comment('tOboGo_GlutamateSynthaseComplexNADPH',s("A","complex","that","possesses","glutamate","synthase","(","NADPH",")","activity","."),4259637). assertion_content_comment('tOboGo_GlutamateSynthaseComplex',s("A","complex","that","possesses","glutamate","synthase","activity","."),4093373). assertion_content_comment('tOboGo_GlutamateSynthaseFerredoxinActivity',s("Catalysis","of","the","reaction",":","2","L-glutamate","+","2","oxidized","ferredoxin","=","L-glutamine","+","2-oxoglutarate","+","2","reduced","ferredoxin","+","2","H","+"),4303484). assertion_content_comment('tOboGo_GlutamateSynthaseNADHActivity',s("Catalysis","of","the","reaction",":","2","L-glutamate","+","NAD","(","+",")","=","2-oxoglutarate","+","L-glutamine","+","H","(","+",")","+","NADH","."),4303454). assertion_content_comment('tOboGo_GlutamateSynthaseNADPHActivity',s("Catalysis","of","the","reaction",":","2","L-glutamate","+","NADP","(","+",")","=","2-oxoglutarate","+","L-glutamine","+","H","(","+",")","+","NADPH","."),4207779). assertion_content_comment('tOboGo_GlutamateUptakeInvolvedInSynapticTransmission',s("The","uptake","of","L-glutamate","by","neurons","or","glial","cells",".","This","process","leads","to","inactivation","and","recycling","of","neurotransmitters","."),4120508). assertion_content_comment('tOboGo_GlutaminaseActivity',s("Catalysis","of","the","reaction",":","L-glutamine","+","H2O","=","L-glutamate","+","NH3","."),4207840). assertion_content_comment('tOboGo_GlutamineBinding',s("Interacting","selectively","and","non-covalently","with","glutamine",",","2",",","5-diamino-5-oxopentanoic","acid","."),4175695). assertion_content_comment('tOboGo_GlutamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glutamine",",","2-amino-4-carbamoylbutanoic","acid","."),4231380). assertion_content_comment('tOboGo_GlutamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glutamine",",","2-amino-4-carbamoylbutanoic","acid","."),4231366). assertion_content_comment('tOboGo_GlutamineFamilyAminoAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","amino","acids","of","the","glutamine","family",",","comprising","arginine",",","glutamate",",","glutamine","and","proline","."),4139246). assertion_content_comment('tOboGo_GlutamineFamilyAminoAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","amino","acids","of","the","glutamine","family",",","comprising","arginine",",","glutamate",",","glutamine","and","proline","."),4231361). assertion_content_comment('tOboGo_GlutamineFamilyAminoAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","amino","acids","of","the","glutamine","family",",","comprising","arginine",",","glutamate",",","glutamine","and","proline","."),3979015). assertion_content_comment('tOboGo_GlutamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glutamine",",","2-amino-4-carbamoylbutanoic","acid","."),4042385). assertion_content_comment('tOboGo_GlutamineSecretion',s("The","controlled","release","of","glutamine","by","a","cell",",","a","group","of","cells",",","or","a","tissue","."),4336290). assertion_content_comment('tOboGo_GlutamineTransport',s("The","directed","movement","of","glutamine",",","2-amino-4-carbamoylbutanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4145801). assertion_content_comment('tOboGo_GlutamylAminopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","a","N-terminal","glutamate","(","and","to","a","lesser","extent","aspartate",")","from","a","peptide","."),4210026). assertion_content_comment('tOboGo_GlutaredoxinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","small","disulfide-containing","redox","protein","that","serves","as","a","glutathione-disulfide","oxidoreductase","."),4316253). assertion_content_comment('tOboGo_Glutaredoxin',s("OBSOLETE",".","A","small","disulfide-containing","redox","protein","that","serves","as","a","glutathione-disulfide","oxidoreductase","."),4259195). assertion_content_comment('tOboGo_GlutathioneBinding',s("Interacting","selectively","and","non-covalently","with","glutathione",";","a","tripeptide","composed","of","the","three","amino","acids","cysteine",",","glutamic","acid","and","glycine","."),4318545). assertion_content_comment('tOboGo_GlutathioneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glutathione",",","the","tripeptide","glutamylcysteinylglycine",",","which","acts","as","a","coenzyme","for","some","enzymes","and","as","an","antioxidant","in","the","protection","of","sulfhydryl","groups","in","enzymes","and","other","proteins","."),4229362). assertion_content_comment('tOboGo_GlutathioneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glutathione",",","the","tripeptide","glutamylcysteinylglycine",",","which","acts","as","a","coenzyme","for","some","enzymes","and","as","an","antioxidant","in","the","protection","of","sulfhydryl","groups","in","enzymes","and","other","proteins","."),4229346). assertion_content_comment('tOboGo_GlutathioneConjugationReaction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228865). assertion_content_comment('tOboGo_GlutathioneDehydrogenaseAscorbateActivity',s("Catalysis","of","the","reaction",":","dehydroascorbate","+","2","glutathione","=","L-ascorbate","+","glutathione","disulfide","."),4300242). assertion_content_comment('tOboGo_GlutathioneDisulfideOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","2","glutathione","+","electron","acceptor","=","glutathione","disulfide","+","electron","donor","."),4207491). assertion_content_comment('tOboGo_GlutathioneImportIntoVacuole',s("The","directed","movement","of","glutathione","into","the","vacuole","."),4169049). assertion_content_comment('tOboGo_GlutathioneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glutathione",",","the","tripeptide","glutamylcysteinylglycine",",","which","acts","as","a","coenzyme","for","some","enzymes","and","as","an","antioxidant","in","the","protection","of","sulfhydryl","groups","in","enzymes","and","other","proteins",";","it","has","a","specific","role","in","the","reduction","of","hydrogen","peroxide","(","H2O2",")","and","oxidized","ascorbate",",","and","it","participates","in","the","gamma-glutamyl","cycle","."),4228172). assertion_content_comment('tOboGo_GlutathioneOxidaseActivity',s("Catalysis","of","the","reaction",":","2","glutathione","+","O","(","2",")","=","glutathione","disulfide","+","H","(","2",")","O","(","2",")"),4377378). assertion_content_comment('tOboGo_GlutathionePeroxidaseActivity',s("Catalysis","of","the","reaction",":","2","glutathione","+","hydrogen","peroxide","=","oxidized","glutathione","+","2","H2O","."),4203724). assertion_content_comment('tOboGo_GlutathioneSynthaseActivity',s("Catalysis","of","the","reaction",":","L-gamma-glutamyl-L-cysteine","+","ATP","+","glycine","=","ADP","+","glutathione","+","2","H","(","+",")","+","phosphate","."),4207447). assertion_content_comment('tOboGo_GlutathioneThiolesteraseActivity',s("Catalysis","of","the","reaction",":","S-acylglutathione","+","H","(","2",")","O","=","a","carboxylate","+","glutathione","+","H","(","+",")"),4377401). assertion_content_comment('tOboGo_GlutathioneTransferaseActivity',s("Catalysis","of","the","reaction",":","R-X","+","glutathione","=","H-X","+","R-S-glutathione",".","R","may","be","an","aliphatic",",","aromatic","or","heterocyclic","group",";","X","may","be","a","sulfate",",","nitrile","or","halide","group","."),4207429). assertion_content_comment('tOboGo_GlutathioneTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","glutathione",",","the","tripeptide","glutamylcysteinylglycine",",","across","a","membrane","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4353740). assertion_content_comment('tOboGo_GlutathioneTransmembraneTransport',s("A","process","in","which","glutathione","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4169046). assertion_content_comment('tOboGo_GlutathioneTransport',s("The","directed","movement","of","glutathione",",","the","tripeptide","glutamylcysteinylglycine",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4169043). assertion_content_comment('tOboGo_GlutathionylspermidineAmidaseActivity',s("Catalysis","of","the","reaction",":","N1-","(","gamma-L-glutamyl-L-cysteinyl-glycyl",")","-spermidine","+","H2O","=","gamma-L-glutamyl-L-cysteinyl-glycine","+","spermidine","."),4249291). assertion_content_comment('tOboGo_GlutathionylspermidineSynthaseActivity',s("Catalysis","of","the","reaction",":","gamma-L-glutamyl-L-cysteinyl-glycine","+","spermidine","+","ATP","=","N1-","(","gamma-L-glutamyl-L-cysteinyl-glycyl",")","-spermidine","+","ADP","+","phosphate","."),4249245). assertion_content_comment('tOboGo_GlyceollinSynthaseActivity',s("Catalysis","of","the","reactions",":","2-dimethylallyl-","(","6aS",",","11aS",")","-3",",","6a",",","9-trihydroxypterocarpan","+","NADPH","+","H","+","+","O2","=","glyceollin","+","NADP","+","+","2","H2O",",","and","4-dimethylallyl-","(","6aS",",","11aS",")","-3",",","6a",",","9-trihydroxypterocarpan","+","NADPH","+","H","+","+","O2","=","glyceollin","+","NADP","+","+","2","H2O","."),4342150). assertion_content_comment('tOboGo_GlyceraldehydeDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","D-glyceraldehyde","+","H2O","+","NADP","+","=","D-glycerate","+","NADPH","+","H","+"),4327696). assertion_content_comment('tOboGo_GlyceraldehydeOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","D-glyceraldehyde","+","H2O","+","acceptor","=","D-glycerate","+","reduced","acceptor","."),4327662). assertion_content_comment('tOboGo_GlycerateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-glycerate","+","NAD","+","=","hydroxypyruvate","+","NADH","+","H","+"),4254127). assertion_content_comment('tOboGo_GlycerateKinaseActivity',s("Catalysis","of","the","reaction",":","D-glycerate","+","ATP","=","3-phospho-D-glycerate","+","ADP","+","2","H","(","+",")"),4249319). assertion_content_comment('tOboGo_GlycerolBiosyntheticProcessFromPyruvate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycerol",",","1",",","2",",","3-propanetriol",",","from","other","compounds",",","including","pyruvate","."),4098104). assertion_content_comment('tOboGo_GlycerolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycerol",",","1",",","2",",","3-propanetriol",",","a","sweet",",","hygroscopic",",","viscous","liquid",",","widely","distributed","in","nature","as","a","constituent","of","many","lipids","."),4010596). assertion_content_comment('tOboGo_GlycerolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycerol",",","1",",","2",",","3-propanetriol",",","a","sweet",",","hygroscopic",",","viscous","liquid",",","widely","distributed","in","nature","as","a","constituent","of","many","lipids","."),4242840). assertion_content_comment('tOboGo_GlycerolChannelActivity',s("Catalysis","of","facilitated","diffusion","of","glycerol","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel","without","evidence","for","a","carrier-mediated","mechanism","."),4295477). assertion_content_comment('tOboGo_GlycerolDehydrataseActivity',s("Catalysis","of","the","reaction",":","glycerol","=","3-hydroxypropanal","+","H2O","."),4351377). assertion_content_comment('tOboGo_GlycerolDehydrogenaseAcceptorActivity',s("Catalysis","of","the","reaction",":","A","+","glycerol","=","AH","(","2",")","+","glycerone","."),4377467). assertion_content_comment('tOboGo_GlycerolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","glycerol","+","NAD","(","+",")","=","glycerone","+","H","(","+",")","+","NADH","."),4249337). assertion_content_comment('tOboGo_GlycerolDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","glycerol","+","NADP","+","=","D-glyceraldehyde","+","NADPH","."),4377753). assertion_content_comment('tOboGo_GlycerolEtherBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycerol","ethers",",","any","anhydride","formed","between","two","organic","hydroxy","compounds",",","one","of","which","is","glycerol","."),4036996). assertion_content_comment('tOboGo_GlycerolEtherCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycerol","ethers",",","any","anhydride","formed","between","two","organic","hydroxy","compounds",",","one","of","which","is","glycerol","."),4037632). 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assertion_content_comment('tOboGo_GlycerolTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","glycerol","from","one","side","of","the","membrane","to","the","other",".","Glycerol","is","1",",","2",",","3-propanetriol",",","a","sweet",",","hygroscopic",",","viscous","liquid",",","widely","distributed","in","nature","as","a","constituent","of","many","lipids","."),4179026). assertion_content_comment('tOboGo_GlycerolTransport',s("The","directed","movement","of","glycerol","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Glycerol","is","1",",","2",",","3-propanetriol",",","a","sweet",",","hygroscopic",",","viscous","liquid",",","widely","distributed","in","nature","as","a","constituent","of","many","lipids","."),4151262). 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assertion_content_comment('tOboGo_GlycerophosphodiesterPhosphodiesteraseActivity',s("Catalysis","of","the","reaction",":","a","glycerophosphodiester","+","H2O","=","an","alcohol","+","sn-glycerol","3-phosphate","."),4249304). assertion_content_comment('tOboGo_GlycerophosphodiesterTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","glycerophosphodiesters","from","one","side","of","a","membrane","to","the","other",".","Glycerophosphodiesters","are","small","molecules","composed","of","glycerol-3-phosphate","and","an","alcohol",",","for","example",",","glycerophosphoinositol","."),4360398). 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assertion_content_comment('tOboGo_GlycerophosphoinositolInositolphosphodiesteraseActivity',s("Catalysis","of","the","reaction",":","H2O","+","1-","(","sn-glycero-3-phospho",")","-1D-myoinositol","=","1D-myo-inositol","1-phosphate","+","glycerol","."),4368467). assertion_content_comment('tOboGo_GlycerophospholipaseInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","a","glycerophospholipase",",","an","enzyme","that","catalyzes","of","the","hydrolysis","of","a","glycerophospholipid","."),4222161). assertion_content_comment('tOboGo_GlycerophospholipidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycerophospholipids",",","any","derivative","of","glycerophosphate","that","contains","at","least","one","O-acyl",",","O-alkyl",",","or","O-alkenyl","group","attached","to","the","glycerol","residue","."),4030217). assertion_content_comment('tOboGo_GlycerophospholipidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycerophospholipids",",","any","derivative","of","glycerophosphate","that","contains","at","least","one","O-acyl",",","O-alkyl",",","or","O-alkenyl","group","attached","to","the","glycerol","residue","."),4037929). assertion_content_comment('tOboGo_GlycerophospholipidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glycerophospholipids",",","any","derivative","of","glycerophosphate","that","contains","at","least","one","O-acyl",",","O-alkyl",",","or","O-alkenyl","group","attached","to","the","glycerol","residue","."),4030193). assertion_content_comment('tOboGo_GlycineAmidinotransferaseActivity',s("Catalysis","of","the","reaction",":","L-arginine","+","glycine","=","L-ornithine","+","guanidinoacetate","."),4297051). assertion_content_comment('tOboGo_GlycineBetaineBiosyntheticProcessFromCholine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","betaine","(","N-trimethylglycine",")","from","the","oxidation","of","choline","."),4239021). assertion_content_comment('tOboGo_GlycineBetaineBiosyntheticProcessFromGlycine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycine","betaine","from","other","compounds",",","including","glycine","."),4239037). assertion_content_comment('tOboGo_GlycineBetaineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycine","betaine",",","N-trimethylglycine","."),4239013). assertion_content_comment('tOboGo_GlycineBetaineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycine","betaine",",","N-trimethylglycine","."),4321451). 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assertion_content_comment('tOboGo_GlycineCleavageComplex',s("A","protein","complex","that","catalyzes","the","reversible","oxidation","of","glycine",".","In","E",".","coli",",","it","has","four","components",":","dihydrolipoamide","dehydrogenase",",","glycine","dehydrogenase","(","decarboxylating",")",",","lipoyl-GcvH-protein","and","aminomethyltransferase",",","also","known","as","L",",","P",",","H",",","and","T","."),4221014). assertion_content_comment('tOboGo_GlycineCleavageSystem',s("OBSOLETE",".","Catalysis","of","the","reactions",":","glycine","+","lipoylprotein","=","S-aminomethyldihydrolipoylprotein","+","carbon","dioxide","(","CO2",")",",","followed","by","S-aminomethyldihydrolipoylprotein","+","(","6S",")","-tetrahydrofolate","=","dihydrolipoylprotein","+","(","6R",")","-5",",","10-methylenetetrahydrofolate","+","ammonia",".","Made","up","of","two","components",",","aminomethyltransferase","and","glycine","dehydrogenase","(","decarboxylating",")"),4207215). assertion_content_comment('tOboGo_GlycineDecarboxylationViaGlycineCleavageSystem',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycine","by","oxidative","cleavage","to","carbon","dioxide",",","ammonia",",","and","a","methylene","group",",","mediated","by","enzymes","of","the","glycine","cleavage","complex","."),4207211). assertion_content_comment('tOboGo_GlycineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","glycine","+","H2O","+","NAD","+","=","glyoxylate","+","NH3","+","NADH","."),4377641). assertion_content_comment('tOboGo_GlycineDehydrogenaseCytochromeActivity',s("Catalysis","of","the","reaction",":","glycine","+","H2O","+","2","ferricytochrome","c","=","glyoxylate","+","NH3","+","2","ferrocytochrome","c","."),4377714). assertion_content_comment('tOboGo_GlycineDehydrogenaseDecarboxylatingActivity',s("Catalysis","of","the","reaction",":","glycine","+","lipoylprotein","=","S-aminomethyldihydrolipoylprotein","+","CO2","."),4207266). assertion_content_comment('tOboGo_GlycineFormimidoyltransferaseActivity',s("Catalysis","of","the","reaction",":","5-formimidoyltetrahydrofolate","+","glycine","=","(","6S",")","-5",",","6",",","7",",","8-tetrahydrofolate","+","N-formimidoylglycine","."),4310220). assertion_content_comment('tOboGo_GlycineHydroxymethyltransferaseActivity',s("Catalysis","of","the","reaction",":","5",",","10-methylenetetrahydrofolate","+","glycine","+","H2O","=","tetrahydrofolate","+","L-serine","."),4207301). assertion_content_comment('tOboGo_GlycineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glycine",",","aminoethanoic","acid","."),4207188). assertion_content_comment('tOboGo_GlycineOxidaseActivity',s("Catalysis","of","the","reactions",":","(","1",")","glycine","+","H2O","+","O2","=","glyoxylate","+","NH3","+","hydrogen","peroxide",";","(","2",")","D-alanine","+","H2O","+","O2","=","pyruvate","+","NH3","+","hydrogen","peroxide",";","(","3",")","sarcosine","+","H2O","+","O2","=","glyoxylate","+","methylamine","+","hydrogen","peroxide",";","(","4",")","N-ethylglycine","+","H2O","+","O2","=","glyoxylate","+","ethylamine","+","hydrogen","peroxide","."),4327640). assertion_content_comment('tOboGo_GlycineReceptorClustering',s("The","receptor","clustering","process","in","which","glycine","receptors","are","localized","to","distinct","domains","in","the","cell","membrane","."),4157682). assertion_content_comment('tOboGo_GlycineReductaseActivity',s("Catalysis","of","the","reaction",":","acetyl","phosphate","+","H","(","2",")","O","+","NH","(","4",")","(","+",")","+","thioredoxin","disulfide","=","glycine","+","H","(","+",")","+","phosphate","+","thioredoxin","."),4308398). assertion_content_comment('tOboGo_GlycineReductaseComplex',s("Complex","that","possesses","glycine","reductase","activity",";","usually","comprises","three","subunits",",","of","which","two","are","selenoproteins",";","the","subunits","are","typically","designated","selenoprotein","A",",","selenoprotein","B","and","protein","C","."),4309302). assertion_content_comment('tOboGo_Glycine_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","glycine","(","out",")","+","Na","+","(","out",")","=","glycine","(","in",")","+","Na","+","(","in",")"),4295861). assertion_content_comment('tOboGo_GlycineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","glycine","from","one","side","of","a","membrane","to","the","other",".","Glycine","is","aminoethanoic","acid","."),4293232). assertion_content_comment('tOboGo_GlycineTransport',s("The","directed","movement","of","glycine",",","aminoethanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293803). assertion_content_comment('tOboGo_Glycocalyx',s("A","viscous",",","carbohydrate","rich","layer","at","the","outermost","periphery","of","a","cell","."),4310944). assertion_content_comment('tOboGo_GlycochenodeoxycholateSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phospho-5","'","-adenylyl","sulfate","+","glycochenodeoxycholate","=","adenosine","3","'",",","5","'","-diphosphate","+","glycochenodeoxycholate","7-sulfate","+","H","(","+",")"),4343493). assertion_content_comment('tOboGo_GlycogenBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycogen",",","a","polydisperse",",","highly","branched","glucan","composed","of","chains","of","D-glucose","residues","."),4009104). assertion_content_comment('tOboGo_GlycogenCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycogen",",","a","polydisperse",",","highly","branched","glucan","composed","of","chains","of","D-glucose","residues","."),4008872). assertion_content_comment('tOboGo_GlycogenCellDevelopmentInvolvedInEmbryonicPlacentaDevelopment',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","glycogen","cell","of","the","placenta",".","A","glycogen","cell","is","a","vacuolated","glycogen-rich","cell","that","appears","in","compact","cell","islets","of","the","spongiotrophoblast","layer","."),4112624). assertion_content_comment('tOboGo_GlycogenDebranchingEnzymeActivity',s("Catalysis","of","the","cleavage","of","branch","points","in","branched","glycogen","polymers","."),4211736). assertion_content_comment('tOboGo_GlycogenGranule',s("Cytoplasmic","bead-like","structures","of","animal","cells",",","visible","by","electron","microscope",".","Each","granule","is","a","functional","unit","with","the","biosynthesis","and","catabolism","of","glycogen","being","catalyzed","by","enzymes","bound","to","the","granule","surface","."),4316798). assertion_content_comment('tOboGo_GlycogeninGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","glycogenin","=","UDP","+","glucosylglycogenin","."),4254111). assertion_content_comment('tOboGo_GlycogenMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glycogen",",","a","polydisperse",",","highly","branched","glucan","composed","of","chains","of","D-glucose","residues","in","alpha","(","1-","&","gt",";","4",")","glycosidic","linkage",",","joined","together","by","alpha","(","1-","&","gt",";","6",")","glycosidic","linkages","."),4008792). assertion_content_comment('tOboGo_GlycogenPhosphorylaseActivity',s("Catalysis","of","the","reaction",":","glycogen","+","phosphate","=","maltodextrin","+","alpha-D-glucose","1-phosphate","."),4246199). assertion_content_comment('tOboGo_GlycogenStarchSynthaseActivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","(","1",",","4",")","-alpha-D-glucosyl","(","n",")","=","UDP","+","(","1",",","4",")","-alpha-D-glucosyl","(","n","+","1",")"),4207226). assertion_content_comment('tOboGo_GlycolaldehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","glycolaldehyde","+","H","(","2",")","O","+","NAD","(","+",")","=","glycolate","+","2","H","(","+",")","+","NADH","."),4268437). assertion_content_comment('tOboGo_GlycolateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycolate",",","the","anion","of","hydroxyethanoic","acid","(","glycolic","acid",")"),4353070). assertion_content_comment('tOboGo_GlycolateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycolate",",","the","anion","of","hydroxyethanoic","acid","(","glycolic","acid",")"),4353118). assertion_content_comment('tOboGo_GlycolateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","A","+","glycolate","=","AH","(","2",")","+","glyoxylate","."),4237598). assertion_content_comment('tOboGo_GlycolateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glycolate",",","the","anion","of","hydroxyethanoic","acid","(","glycolic","acid",")"),4258707). assertion_content_comment('tOboGo_GlycolateOxidaseActivity',s("Catalysis","of","the","reaction",":","glycolate","+","O2","=","glyoxylate","+","hydrogen","peroxide","."),4249364). assertion_content_comment('tOboGo_GlycolateOxidaseComplex',s("An","enzyme","complex","that","catalyzes","the","oxidation","of","2-hydroxy","acid","to","form","2-oxo","acid","and","hydrogen","peroxide","(","H2O2",")","The","enzyme","is","a","flavoprotein","(","FMN",")"),4259770). assertion_content_comment('tOboGo_GlycolateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","glycolate","from","one","side","of","a","membrane","to","the","other",".","Glycolate","is","the","smallest","alpha-hydroxy","acid","(","AHA",")"),4326850). assertion_content_comment('tOboGo_GlycolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycol",",","any","of","a","class","of","alcohols","having","2","hydroxyl","groups","in","each","molecule","."),4074407). assertion_content_comment('tOboGo_GlycolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","glycol",",","any","of","a","class","of","alcohols","having","2","hydroxyl","groups","in","each","molecule","."),4315135). assertion_content_comment('tOboGo_GlycolipidBinding',s("Interacting","selectively","and","non-covalently","with","a","glycolipid",",","any","compound","containing","one","or","more","monosaccharide","residues","bound","by","a","glycosidic","linkage","to","a","hydrophobic","group","such","as","an","acylglycerol",",","a","sphingoid",",","a","ceramide","(","N-acylsphingoid",")","or","a","prenyl","phosphate","."),4282123). assertion_content_comment('tOboGo_GlycolipidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","glycolipid",",","a","class","of","1",",","2-di-O-acylglycerols","joined","at","oxygen","3","by","a","glycosidic","linkage","to","a","carbohydrate","part","(","usually","a","mono-",",","di-","or","tri-saccharide",")"),4024046). 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assertion_content_comment('tOboGo_GlycolipidTransporterActivity',s("Enables","the","directed","movement","of","glycolipids",",","compounds","containing","(","usually",")","1-4","linked","monosaccharide","residues","joined","by","a","glycosyl","linkage","to","a","lipid",",","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4269223). assertion_content_comment('tOboGo_GlycolipidTransport',s("The","directed","movement","of","glycolipids",",","compounds","containing","(","usually",")","1-4","linked","monosaccharide","residues","joined","by","a","glycosyl","linkage","to","a","lipid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4358096). assertion_content_comment('tOboGo_GlycolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","glycol",",","any","of","a","class","of","alcohols","having","2","hydroxyl","groups","in","each","molecule","."),4074402). assertion_content_comment('tOboGo_Glycolysis',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","monosaccharide","(","generally","glucose",")","into","pyruvate",",","with","the","concomitant","production","of","a","small","amount","of","ATP",".","Pyruvate","may","be","converted","to","ethanol",",","lactate",",","or","other","small","molecules",",","or","fed","into","the","TCA","cycle","."),4010429). assertion_content_comment('tOboGo_GlycolyticFermentation',s("Fermentation","that","includes","the","anaerobic","conversion","of","glucose","to","pyruvate","via","the","glycolytic","pathway","."),4096231). 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assertion_content_comment('tOboGo_GSEComplex',s("A","conserved","protein","complex","required","for","protein","sorting","from","endosome","to","the","plasma","membrane",".","In","budding","yeast",",","S",".","cerevisiae",",","this","complex","includes","Gtr1p",",","Gtr2p",",","Slm4p",",","Meh1p","and","Ltv1p","and","it","sorts","Gap1p","."),4357178). 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assertion_content_comment('tOboGo_GuanosineTetraphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","guanine","tetraphosphate","(","5","'","-ppGpp-3","'",")",",","a","derivative","of","guanine","riboside","with","four","phosphates","."),4294947). assertion_content_comment('tOboGo_GuanosineTetraphosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","guanine","tetraphosphate","(","5","'","-ppGpp-3","'",")",",","a","derivative","of","guanine","riboside","with","four","phosphates","."),4294930). assertion_content_comment('tOboGo_GuanosineTetraphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","guanine","tetraphosphate","(","5","'","-ppGpp-3","'",")",",","a","derivative","of","guanine","riboside","with","four","phosphates","."),4294924). assertion_content_comment('tOboGo_GuanylateCyclaseActivatorActivity',s("Increases","the","activity","of","guanylate","cyclase","."),4246865). assertion_content_comment('tOboGo_GuanylateCyclaseActivity',s("Catalysis","of","the","reaction",":","GTP","=","3","'",",","5","'","-cyclic","GMP","+","diphosphate","."),4208171). assertion_content_comment('tOboGo_GuanylateCyclaseComplexSoluble',s("Complex","that","possesses","guanylate","cyclase","activity","and","is","not","bound","to","a","membrane","."),4247232). assertion_content_comment('tOboGo_GuanylateCyclaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","guanylate","cyclase","."),4311655). assertion_content_comment('tOboGo_GuanylateCyclaseRegulatorActivity',s("Modulates","the","activity","of","guanylate","cyclase","."),4246863). assertion_content_comment('tOboGo_GuanylateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","GMP","=","ADP","+","GDP","."),4208240). assertion_content_comment('tOboGo_GuanylDeoxyribonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","guanyl","deoxyribonucleotide",",","any","compound","consisting","of","guanosine","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","deoxyribose","moiety","."),4331809). assertion_content_comment('tOboGo_GuanylNucleotideBinding',s("Interacting","selectively","and","non-covalently","with","guanyl","nucleotides",",","any","compound","consisting","of","guanosine","esterified","with","(","ortho",")","phosphate","."),4218772). assertion_content_comment('tOboGo_GuanylRibonucleotideBinding',s("Interacting","selectively","and","non-covalently","with","a","guanyl","ribonucleotide",",","any","compound","consisting","of","guanosine","esterified","with","(","ortho",")","phosphate","or","an","oligophosphate","at","any","hydroxyl","group","on","the","ribose","moiety","."),4218775). assertion_content_comment('tOboGo_GuanylyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","guanylyl","group","to","an","acceptor","."),4174769). assertion_content_comment('tOboGo_GuardCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","guard","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4029553). assertion_content_comment('tOboGo_GuardCellDifferentiation',s("The","process","in","which","a","guard","mother","cell","acquires","the","specialized","features","of","a","guard","cell","."),4029542). assertion_content_comment('tOboGo_GuardCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","stomatal","guard","cell",".","Guard","cells","are","located","in","the","leaf","epidermis","and","pairwise","surround","stomatal","pores",",","which","allow","CO2","influx","for","photosynthetic","carbon","fixation","and","water","loss","via","transpiration","to","the","atmosphere","."),4031319). assertion_content_comment('tOboGo_GuardCellMorphogenesis',s("Generation","and","organization","of","the","polarized","cell","that","is","capable","of","turgor","driven","movement","."),4029575). assertion_content_comment('tOboGo_GuardMotherCellCytokinesis',s("The","stereotyped","symmetric","cell","division","by","which","guard","mother","cell","give","rise","to","stomatal","guard","cells","."),4032097). assertion_content_comment('tOboGo_GuardMotherCellDifferentiation',s("The","process","in","which","a","meristemoid","acquires","the","specialized","features","of","a","guard","mother","cell","."),4029511). assertion_content_comment('tOboGo_GuidingStereospecificSynthesisActivity',s("The","orientation","of","free","radical","substrates","in","such","a","way","that","only","a","particular","stereoisomer","is","synthesized","by","an","enzyme",".","Best","characterized","as","a","function","during","lignan","biosynthesis","."),4312996). assertion_content_comment('tOboGo_GurkenReceptorActivity',s("Combining","with","the","ligand","Gurken","to","initiate","a","change","in","cell","activity","."),4255442). assertion_content_comment('tOboGo_GurkenReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","gurken","growth","factor","receptor","."),4255368). assertion_content_comment('tOboGo_GurkenReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","epidermal","growth","factor","receptor","binding","to","the","ligand","Gurken","."),4255451). assertion_content_comment('tOboGo_GynoeciumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","gynoecium","over","time",",","from","its","formation","to","the","mature","structure",".","The","gynoecium","is","the","collective","name","for","the","carpels","of","a","flower","."),4028888). assertion_content_comment('tOboGo_H1HistamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","H1","histamine","receptor","."),4324431). assertion_content_comment('tOboGo_H2AHistoneAcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","histone","H2A","L-lysine","=","CoA","+","histone","H2A","N6-acetyl-L-lysine","."),4289109). assertion_content_comment('tOboGo_H2BHistoneAcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","histone","H2B","L-lysine","=","CoA","+","histone","H2B","N6-acetyl-L-lysine","."),4289122). assertion_content_comment('tOboGo_H2HistamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","H2","histamine","receptor","."),4324421). assertion_content_comment('tOboGo_H3HistamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","H3","histamine","receptor","."),4324451). assertion_content_comment('tOboGo_H3HistoneAcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","histone","H3","=","CoA","+","acetyl-histone","H3","."),4288969). assertion_content_comment('tOboGo_H3HistoneAcetyltransferaseComplex',s("A","multisubunit","complex","that","catalyzes","the","acetylation","of","histone","H3","."),4176413). assertion_content_comment('tOboGo_H4H2AHistoneAcetyltransferaseComplex',s("A","multisubunit","complex","that","catalyzes","the","acetylation","of","histones","H4","and","H2A","."),4317317). assertion_content_comment('tOboGo_H4HistamineReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","H4","histamine","receptor","."),4324551). assertion_content_comment('tOboGo_H4HistoneAcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","histone","H4","=","CoA","+","acetyl-histone","H4","."),4328406). assertion_content_comment('tOboGo_H9MelatoninReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","H9","melatonin","receptor","."),4323549). assertion_content_comment('tOboGo_HA1ClathrinAdaptor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220558). assertion_content_comment('tOboGo_HA2ClathrinAdaptor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220570). assertion_content_comment('tOboGo_HabenulaDevelopment',s("The","progression","of","the","habenula","over","time","from","its","initial","formation","until","its","mature","state",".","The","habenula","is","the","group","of","nuclei","that","makes","up","the","stalk","of","the","pineal","gland","."),4046424). assertion_content_comment('tOboGo_Habituation',s("A","decrease","in","a","behavioral","response","to","a","repeated","stimulus",".","This","is","exemplified","by","the","failure","of","a","person","to","show","a","startle","response","to","a","loud","noise","that","has","been","repeatedly","presented","."),4361947). assertion_content_comment('tOboGo_HairCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","hair","cell","."),3982391). assertion_content_comment('tOboGo_HairCycleProcess',s("A","multicellular","organismal","process","involved","in","the","cyclical","phases","of","growth","(","anagen",")",",","regression","(","catagen",")",",","quiescence","(","telogen",")",",","and","shedding","(","exogen",")","in","the","life","of","a","hair",";","one","of","the","collection","or","mass","of","filaments","growing","from","the","skin","of","an","animal",",","and","forming","a","covering","for","a","part","of","the","head","or","for","any","part","or","the","whole","of","the","body","."),4053530). assertion_content_comment('tOboGo_HairCycle',s("The","cyclical","phases","of","growth","(","anagen",")",",","regression","(","catagen",")",",","quiescence","(","telogen",")",",","and","shedding","(","exogen",")","in","the","life","of","a","hair",";","one","of","the","collection","or","mass","of","filaments","growing","from","the","skin","of","an","animal",",","and","forming","a","covering","for","a","part","of","the","head","or","for","any","part","or","the","whole","of","the","body","."),4053520). assertion_content_comment('tOboGo_HairFollicleCellProliferation',s("The","multiplication","or","reproduction","of","hair","follicle","cells",",","resulting","in","the","expansion","of","a","cell","population","."),4128324). assertion_content_comment('tOboGo_HairFollicleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","hair","follicle","over","time",",","from","its","formation","to","the","mature","structure",".","A","hair","follicle","is","a","tube-like","opening","in","the","epidermis","where","the","hair","shaft","develops","and","into","which","the","sebaceous","glands","open","."),4062696). assertion_content_comment('tOboGo_HairFollicleMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","hair","follicle","to","attain","its","fully","functional","state","."),4077867). assertion_content_comment('tOboGo_HairFollicleMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","hair","follicle","are","generated","and","organized","."),4062699). assertion_content_comment('tOboGo_HairFolliclePlacodeFormation',s("The","developmental","process","in","which","a","hair","placode","forms",".","An","hair","follicle","placode","is","a","thickening","of","the","ectoderm","that","will","give","rise","to","the","hair","follicle","bud","."),4110842). assertion_content_comment('tOboGo_HalfBridgeOfSpindlePoleBody',s("Structure","adjacent","to","the","plaques","of","the","spindle","pole","body","."),4007245). assertion_content_comment('tOboGo_HaloacetateDehalogenaseActivity',s("Catalysis","of","the","reaction",":","haloacetate","+","H2O","=","glycolate","+","halide","."),4274262). assertion_content_comment('tOboGo_HaloalkaneDehalogenaseActivity',s("Catalysis","of","the","reaction",":","1-haloalkane","+","H2O","=","a","primary","alcohol","+","halide","."),4274274). assertion_content_comment('tOboGo_HalogenatedHydrocarbonCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","halogenated","hydrocarbons",",","any","hydrocarbon","with","one","or","more","halogen","atoms","attached","to","it","."),4238296). assertion_content_comment('tOboGo_HalogenatedHydrocarbonMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","halogenated","hydrocarbons",",","any","hydrocarbon","with","one","or","more","halogen","atoms","attached","to","it",".","Halogens","include","fluorine",",","chlorine",",","bromine","and","iodine","."),4045248). assertion_content_comment('tOboGo_HalogenMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","halogen",",","elements","of","Group","VII",";","includes","metabolism","of","halogen-containing","compounds","."),4174197). assertion_content_comment('tOboGo_HaltereDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","haltere","over","time",",","from","its","formation","to","the","mature","structure",".","The","haltere","is","the","club-shaped","'","balancers","'","found","on","each","side","of","the","metathorax","among","the","true","flies","(","Diptera",")","They","are","the","much-modified","hind","wings","."),4018052). assertion_content_comment('tOboGo_HaltereDiscDevelopment',s("Progression","of","the","haltere","imaginal","disc","over","time",",","from","its","initial","formation","through","to","its","metamorphosis","to","form","the","adult","capitellum",",","pedicel",",","haltere","sclerite",",","metathoracic","spiracle","and","metanotum","."),4018042). assertion_content_comment('tOboGo_HaltereDiscMorphogenesis',s("The","process","in","which","the","anatomical","structures","derived","from","the","haltere","disc","are","generated","and","organized",".","This","includes","the","transformation","of","a","haltere","imaginal","disc","from","a","monolayered","epithelium","in","the","larvae","of","holometabolous","insects","into","the","recognizable","adult","capitellum",",","pedicel",",","haltere","sclerite",",","metathoracic","spiracle","and","metanotum","."),4018105). assertion_content_comment('tOboGo_HaltereMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","haltere","are","generated","and","organized","."),4107418). assertion_content_comment('tOboGo_HamameloseKinaseActivity',s("Catalysis","of","the","reaction",":","D-hamamelose","+","ATP","=","D-hamamelose","2","'","-phosphate","+","ADP","+","2","H","(","+",")"),4378691). assertion_content_comment('tOboGo_HaptoglobinBinding',s("Interacting","selectively","and","non-covalently","with","a","haptoglobin",",","any","alpha2","globulin","of","blood","plasma","that","can","combine","with","free","oxyhemoglobin","to","form","a","stable","complex","."),4323261). assertion_content_comment('tOboGo_HarderianGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","Harderian","gland","over","time",",","from","its","formation","to","the","mature","structure",".","The","Harderian","gland","is","an","anterior","orbital","structure","usually","associated","with","the","nictitating","membrane",",","and","produces","and","secretes","a","variety","of","substances","to","the","eye",",","depending","upon","the","species","."),4173618). assertion_content_comment('tOboGo_HardPalateDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","the","hard","palate","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","structure","and","ends","with","the","mature","structure",",","whatever","form","that","may","be","including","its","natural","destruction",".","The","hard","palate","is","the","anterior","portion","of","the","palate","consisting","of","bone","and","mucous","membranes","."),4109651). assertion_content_comment('tOboGo_HatchingBehavior',s("The","specific","actions","or","reactions","of","an","organism","during","the","emergence","from","an","egg","shell",".","In","Drosophila","for","example",",","the","larva","swings","its","head","reiteratively","through","a","semicircular","arc",",","using","its","mouth","hooks","to","tear","apart","the","chorion","in","front","of","it","and","thus","free","itself","from","within","the","egg","shell","."),4071991). assertion_content_comment('tOboGo_HatchingGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","hatching","gland","over","time",",","from","its","formation","to","the","mature","structure",".","The","cells","of","the","hatching","gland","contain","enzymes","responsible","for","solubilization","of","the","egg","chorion",",","facilitating","the","hatching","process","."),4330152). assertion_content_comment('tOboGo_Hatching',s("The","emergence","of","an","immature","organism","from","a","protective","structure","."),3987114). assertion_content_comment('tOboGo_HAUSComplex',s("A","protein","complex","that","localizes","to","interphase","centrosomes","and","to","mitotic","spindle","tubules","and","regulates","mitotic","spindle","assembly","and","centrosome","integrity",";","in","human",",","the","complex","consists","of","eight","subunits",",","some","of","which","are","homologous","to","subunits","of","the","Drosophila","Augmin","complex","."),4177453). assertion_content_comment('tOboGo_HaustoriumMotherCellFormationOnOrNearHost',s("The","process","in","which","a","symbiont","cell","is","formed","on","or","near","its","host","organism",",","via","separated","from","the","tip","of","an","infection","hypha","by","a","septum",".","The","haustorium","mother","cell","usually","contains","2-4","fungal","nuclei",",","and","its","function","is","to","attach","and","penetrate","the","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146657). assertion_content_comment('tOboGo_Haustorium',s("A","projection","from","a","cell","or","tissue","that","penetrates","the","host","'","s","cell","wall","and","invaginates","the","host","cell","membrane","."),4083846). assertion_content_comment('tOboGo_HDA1Complex',s("A","tetrameric","histone","deacetylase","complex","that","contains","a","Class","II","deacetylase","catalytic","subunit",".","In","S",".","cerevisiae","it","is","composed","of","two","Hda1p","subunits","along","with","Hda2p","and","Hda3p","."),4178931). assertion_content_comment('tOboGo_HDELSequenceBinding',s("Interacting","selectively","and","non-covalently","with","a","HDEL","sequence",",","the","C","terminus","tetrapeptide","sequence","His-Asp-Glu-Leu","found","in","proteins","that","are","to","be","retained","in","the","endoplasmic","reticulum","."),4300581). assertion_content_comment('tOboGo_HeadDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","head","from","an","initial","condition","to","its","mature","state",".","The","head","is","the","anterior-most","division","of","the","body","."),4114749). assertion_content_comment('tOboGo_HeadInvolution',s("Movement","of","the","anterior","ectoderm","to","the","interior","of","the","embryo","."),4016051). assertion_content_comment('tOboGo_HeadKidneyDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","head","kidney","over","time",",","from","its","formation","to","the","mature","structure",".","The","head","kidney","is","a","pronephros","that","consists","of","fused","bilateral","lobes","located","in","the","anterior","part","of","the","kidney",".","It","is","analogous","to","the","mammalian","bone","marrow","and","the","primary","site","of","definitive","hematopoiesis","."),4122622). assertion_content_comment('tOboGo_HeadKidneyFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","head","kidney",".","The","head","kidney","is","a","pronephros","that","consists","of","fused","bilateral","lobes","located","in","the","anterior","part","of","the","kidney","."),4122663). assertion_content_comment('tOboGo_HeadKidneyMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","head","kidney","to","attain","its","fully","functional","state",".","The","head","kidney","is","a","pronephros","that","consists","of","fused","bilateral","lobes","located","in","the","anterior","part","of","the","kidney","."),4122696). assertion_content_comment('tOboGo_HeadKidneyMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","head","kidney","are","generated","and","organized",".","The","head","kidney","is","a","pronephros","that","consists","of","fused","bilateral","lobes","located","in","the","anterior","part","of","the","kidney","."),4122632). assertion_content_comment('tOboGo_HeadKidneyStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","head","kidney",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","head","kidney","is","a","pronephros","that","consists","of","fused","bilateral","lobes","located","in","the","anterior","part","of","the","kidney","."),4122653). assertion_content_comment('tOboGo_HeadMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","head","are","generated","and","organized",".","The","head","is","the","anterior-most","division","of","the","body","."),4114751). assertion_content_comment('tOboGo_HeadSegmentation',s("Partitioning","the","head","anlage","into","a","fixed","number","of","segmental","units",".","The","number","of","segments","composing","the","insect","head","has","long","been","a","subject","of","debate",",","but","it","is","generally","agreed","that","there","are","6","or","7","segments",".","From","anterior","to","posterior","the","head","segments","are","the","procephalic","segments","(","labral",",","(","ocular",")",",","antennal","and","intercalary",")","and","the","gnathal","segments","(","mandibular",",","maxillary","and","labial",")"),4019479). 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assertion_content_comment('tOboGo_HemolymphCoagulation',s("Any","process","in","which","factors","in","the","hemolymph","(","the","invertebrate","equivalent","of","vertebrate","blood","and","lymph",")","precipitate","into","insoluble","clots","in","order","to","prevent","loss","of","body","fluid",",","and","at","the","same","time","prevent","the","movement","of","microbes",".","Hemolymph","coagulation","is","also","part","of","the","invertebrate","humoral","immune","response","."),4078439). assertion_content_comment('tOboGo_HemolysinActivity',s("OBSOLETE",".","Any","substance","that","causes","the","lysis","of","red","blood","cells","."),4292569). 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assertion_content_comment('tOboGo_HepaticobiliarySystemDevelopment',s("The","progression","of","the","hepaticobiliary","system","over","time",",","from","its","formation","to","the","mature","structure",".","The","hepaticobiliary","system","is","responsible","for","metabolic","and","catabolic","processing","of","small","molecules","absorbed","from","the","blood","or","gut",",","hormones","and","serum","proteins",",","detoxification",",","storage","of","glycogen",",","triglycerides",",","metals","and","lipid","soluble","vitamins","and","excretion","of","bile",".","Included","are","the","synthesis","of","albumin",",","blood","coagulation","factors",",","complement",",","and","specific","binding","proteins","."),3986623). 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assertion_content_comment('tOboGo_HeterocycleBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","heterocyclic","compounds",",","those","with","a","cyclic","molecular","structure","and","at","least","two","different","atoms","in","the","ring","(","or","rings",")"),4014171). assertion_content_comment('tOboGo_HeterocycleCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","heterocyclic","compounds",",","those","with","a","cyclic","molecular","structure","and","at","least","two","different","atoms","in","the","ring","(","or","rings",")"),4005176). assertion_content_comment('tOboGo_HeterocycleMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","heterocyclic","compounds",",","those","with","a","cyclic","molecular","structure","and","at","least","two","different","atoms","in","the","ring","(","or","rings",")"),4005088). assertion_content_comment('tOboGo_HeterocystDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","heterocyst",",","a","differentiated","cell","in","certain","cyanobacteria","whose","purpose","is","to","fix","nitrogen","."),4317620). assertion_content_comment('tOboGo_HeteroduplexFormation',s("The","formation","of","a","stable","duplex","DNA","that","contains","one","strand","from","each","of","the","two","recombining","DNA","molecules","."),3976871). assertion_content_comment('tOboGo_HeterogeneousNuclearRibonucleoproteinComplex',s("Particulate","complex","of","heterogeneous","nuclear","RNA","(","hnRNA",";","a","heterogeneous","mixture","of","RNA","molecules","of","high","Mr","with","a","rapid","turnover","rate","that","occurs","in","cell","nuclei","during","protein","synthesis",";","it","is","the","form","of","RNA","synthesized","in","eukaryotes","by","RNA","polymerase","II",",","that","which","is","translated","into","protein",")","with","protein",",","which","is","cell-specific","and","heterogeneous",".","The","protein","component","may","play","a","role","in","the","processing","of","the","hnRNA","to","mRNA","."),4253677). assertion_content_comment('tOboGo_HeterogeneousNuclearRibonucleoprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4253682). assertion_content_comment('tOboGo_HeterophilicCellAdhesionInvolvedInCytoadherenceToMicrovasculatureMediatedByParasiteProtein',s("The","attachment","of","a","parasite","adhesion","molecule","to","a","nonidentical","adhesion","molecule","on","the","microvasculature","of","a","host","cell",",","thereby","adhering","the","parasite","to","the","host","cell","."),4095204). assertion_content_comment('tOboGo_HeteropolysaccharideBinding',s("Interacting","selectively","and","non-covalently","with","heteropolysaccharides",".","A","heteropolysaccharide","is","a","glycan","composed","of","more","than","one","type","of","monosaccharide","residue","."),4335108). assertion_content_comment('tOboGo_HeterotetramericADPGPyrophosphorylaseComplex',s("A","protein","complex","composed","of","four","different","subunits","that","possesses","ADPG","pyrophosphorylase","activity",".","An","example","of","this","process","is","found","in","Mus","musculus","."),4061513). assertion_content_comment('tOboGo_HeterotetramericDecaprenylDiphosphateSynthaseComplex',s("A","heterotetrameric","complex","located","in","the","mitochondrial","inner","membrane","that","possesses","di-trans",",","poly-cis-decaprenylcistransferase","activity",";","involved","in","ubiquinone","biosynthesis",".","In","S",".","pombe","it","is","a","heterotetramer","of","Dlp1","and","Dps1","."),4055793). assertion_content_comment('tOboGo_HexachlorocyclohexaneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hexachlorocyclohexane",",","a","cyclohexane","derivative","with","6","chlorine","atoms","attached","to","the","hexane","ring",".","Hexachlorocyclohexane","consists","of","a","mixture","of","8","different","isomers","and","was","used","a","commercial","insecticide",".","It","is","persistent","in","the","environment",",","causing","serious","soil","pollution","."),4240970). assertion_content_comment('tOboGo_HexadecanalBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hexadecanal",",","the","C16","straight","chain","aldehyde","."),4230362). assertion_content_comment('tOboGo_HexadecanalDehydrogenaseAcylatingActivity',s("Catalysis","of","the","reaction",":","CoA","+","NAD","(","+",")","+","palmitaldehyde","=","H","(","+",")","+","NADH","+","palmitoyl-CoA","."),4366010). assertion_content_comment('tOboGo_HexadecanalMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hexadecanal",",","the","C16","straight","chain","aldehyde","."),4230359). assertion_content_comment('tOboGo_HexadecanolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","hexadecanol","+","NAD","+","=","hexadecanal","+","NADH","."),4378811). assertion_content_comment('tOboGo_HexadecyltrimethylammoniumChlorideMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","hexadecyltrimethylammonium","chloride","+","NAD","(","P",")","H","+","H","+","+","O2","=","trimethylamine","+","hexadecanal","+","NAD","(","P",")","+","+","H2O","."),4351223). assertion_content_comment('tOboGo_HexamericIgMImmunoglobulinComplex',s("A","circulating","form","of","IgM","consisting","of","a","hexamer","of","IgM","core","units","with","a","single","J","chain","polypeptide","."),4169691). assertion_content_comment('tOboGo_HexanoyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","hexanoyl","(","CH3-","[","CH2","]","4-CO-",")","group","to","an","acceptor","molecule","."),4355126). assertion_content_comment('tOboGo_HexaprenyldihydroxybenzoateMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","3-hexaprenyl-4",",","5-dihydroxybenzoate","=","S-adenosyl-L-homocysteine","+","3-hexaprenyl-4-hydroxy-5-methoxybenzoate","."),4208114). assertion_content_comment('tOboGo_HexitolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hexitols",",","any","alditol","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4224966). assertion_content_comment('tOboGo_HexitolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hexitols",",","any","alditol","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4225026). assertion_content_comment('tOboGo_HexitolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","hexitol","+","acceptor","=","hexose","+","reduced","acceptor","."),4319654). assertion_content_comment('tOboGo_HexitolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hexitols",",","any","alditol","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4224796). assertion_content_comment('tOboGo_HexokinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","D-hexose","=","ADP","+","D-hexose","6-phosphate","."),4207918). assertion_content_comment('tOboGo_HexonBinding',s("Interacting","selectively","and","non-covalently","with","a","hexon",",","the","major","protein","component","of","the","icosahedral","capsid","of","an","adenovirus","."),4321335). assertion_content_comment('tOboGo_HexosaminidaseActivity',s("Catalysis","of","the","cleavage","of","hexosamine","or","N-acetylhexosamine","residues","(","e.g",".","N-acetylglucosamine",")","residues","from","gangliosides","or","other","glycoside","oligosaccharides","."),4185770). assertion_content_comment('tOboGo_HexoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hexose",",","any","monosaccharide","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4010482). assertion_content_comment('tOboGo_HexoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hexose",",","any","monosaccharide","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4010418). assertion_content_comment('tOboGo_Hexose_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","hexose","(","out",")","+","H","+","(","out",")","=","hexose","(","in",")","+","H","+","(","in",")"),4216443). assertion_content_comment('tOboGo_HexoseMediatedSignaling',s("A","series","of","molecular","signals","mediated","by","the","detection","of","hexose","."),4260356). assertion_content_comment('tOboGo_HexoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","a","hexose",",","any","monosaccharide","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4008979). assertion_content_comment('tOboGo_HexoseOxidaseActivity',s("Catalysis","of","the","reaction",":","beta-D-glucose","+","O2","=","D-glucono-1",",","5-lactone","+","H2O2","."),4378821). assertion_content_comment('tOboGo_HexosePhosphateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","hexose","phosphate","from","one","side","of","the","membrane","to","the","other",".","Hexose","phosphates","is","any","of","a","group","of","monophosphorylated","aldoses","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4292967). assertion_content_comment('tOboGo_HexosePhosphateTransport',s("The","directed","movement","of","hexose","phosphate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290712). assertion_content_comment('tOboGo_HexoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","hexose","sugar",",","a","monosaccharide","with","6","carbon","atoms",",","from","one","side","of","a","membrane","to","the","other","."),4020395). assertion_content_comment('tOboGo_HexoseTransmembraneTransport',s("The","directed","movement","of","hexose","across","a","membrane","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Hexoses","are","any","aldoses","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4083070). assertion_content_comment('tOboGo_HexoseTransport',s("The","directed","movement","of","hexose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Hexoses","are","any","aldoses","with","a","chain","of","six","carbon","atoms","in","the","molecule","."),4036537). assertion_content_comment('tOboGo_HexoseUniporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","hexose","(","out",")","=","hexose","(","in",")"),4254621). assertion_content_comment('tOboGo_Hexuronate_CationSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","hexuronate","(","out",")","+","cation","(","out",")","=","hexuronate","(","in",")","+","cation","(","in",")","The","hexuronate","may","be","glucuronate","or","galacturonate","."),4293275). assertion_content_comment('tOboGo_HexuronateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","hexuronates","from","one","side","of","the","membrane","to","the","other",".","A","hexuronate","is","any","monocarboxylic","acid","derived","from","a","hexose","by","oxidation","of","C-6","."),4293273). assertion_content_comment('tOboGo_HexuronateTransport',s("The","directed","movement","of","hexuronate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","A","hexuronate","is","any","monocarboxylic","acid","derived","from","a","hexose","by","oxidation","of","C-6","."),4290751). assertion_content_comment('tOboGo_HexuronideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","hexuronide","from","one","side","of","the","membrane","to","the","other",".","Hexuronides","are","any","compound","formed","by","combination","of","glycosidic","linkage","of","a","hydroxy","compound","(","e.g",".","an","alcohol","or","a","saccharide",")","with","the","anomeric","carbon","atom","of","a","hexuronate","."),4292493). assertion_content_comment('tOboGo_HexuronideTransport',s("The","directed","movement","of","hexuronide","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Hexuronides","are","any","compound","formed","by","combination","of","glycosidic","linkage","of","a","hydroxy","compound","(","e.g",".","an","alcohol","or","a","saccharide",")","with","the","anomeric","carbon","atom","of","a","hexuronate","."),4291242). assertion_content_comment('tOboGo_Hibernation',s("Any","process","in","which","an","organism","enters","and","maintains","a","period","of","dormancy","in","which","to","pass","the","winter",".","It","is","characterized","by","narcosis","and","by","sharp","reduction","in","body","temperature","and","metabolic","activity","and","by","a","depression","of","vital","signs","."),4097965). assertion_content_comment('tOboGo_HighAffinityArginineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","arginine","from","one","side","of","a","membrane","to","the","other",".","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations","."),4215607). assertion_content_comment('tOboGo_HighAffinityBasicAminoAcidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","basic","amino","acids","from","one","side","of","a","membrane","to","the","other",".","Acidic","amino","acids","have","a","pH","above","7",".","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations","."),4215577). assertion_content_comment('tOboGo_HighAffinityCopperIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Cu2","+","(","out",")","=","Cu2","+","(","in",")"),4297682). assertion_content_comment('tOboGo_HighAffinityFcReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4245557). assertion_content_comment('tOboGo_HighAffinityFerricUptakeTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","Fe","(","III",")","from","the","outside","of","a","cell","to","the","inside","of","a","cell","across","a","membrane","."),4297498). assertion_content_comment('tOboGo_HighAffinityGlutamineTransmembraneTransporterActivity',s("Catalysis","of","the","high","affinity","transfer","of","glutamine","from","one","side","of","the","membrane","to","the","other","."),4296372). assertion_content_comment('tOboGo_HighAffinityIgAReceptorActivity',s("Combining","with","high","affinity","with","an","immunoglobulin","of","an","IgA","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4375797). assertion_content_comment('tOboGo_HighAffinityIgEReceptorActivity',s("Combining","with","high","affinity","with","an","immunoglobulin","of","the","IgE","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4245524). assertion_content_comment('tOboGo_HighAffinityIgGReceptorActivity',s("Combining","with","high","affinity","with","an","immunoglobulin","of","an","IgG","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4245330). assertion_content_comment('tOboGo_HighAffinityIgMReceptorActivity',s("Combining","with","high","affinity","with","an","immunoglobulin","of","an","IgM","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4375815). assertion_content_comment('tOboGo_HighAffinityInorganicPhosphate_SodiumSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","HPO42-","(","out",")","+","Na","+","(","out",")","=","HPO42-","(","in",")","+","Na","+","(","in",")"),4216100). assertion_content_comment('tOboGo_HighAffinityIronPermeaseComplex',s("A","protein","complex","composed","of","a","multicopper","ferroxidase","that","oxidizes","Fe","(","II",")","to","Fe","(","III",")",",","and","a","ferric","iron","permease","that","transports","the","produced","Fe","(","III",")","into","the","cell","."),4340404). assertion_content_comment('tOboGo_HighAffinityLysineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","lysine","from","one","side","of","a","membrane","to","the","other",".","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations","."),4215931). assertion_content_comment('tOboGo_HighAffinityMetalIonUptakeTransporterActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","Me2","+","(","out",")","+","H","+","(","out",")","=","Me2","+","(","in",")","+","H","+","(","in",")","Me","can","be","Fe2","+",",","Mn2","+",",","Zn2","+",",","Cu2","+",",","Cd2","+",",","Ni2","+","or","Co2","+"),4296289). assertion_content_comment('tOboGo_HighAffinityOligopeptideTransporterActivity',s("Catalysis","of","the","transfer","of","oligopeptide","from","one","side","of","the","membrane","to","the","other",".","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations",".","Oligopeptides","are","molecules","that","contain","a","small","number","(","2","to","20",")","of","amino-acid","residues","connected","by","peptide","linkages","."),4296322). assertion_content_comment('tOboGo_HighAffinityPhosphateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","phosphate","from","one","side","of","the","membrane","to","the","other",".","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations","."),4384888). assertion_content_comment('tOboGo_HighAffinitySecondaryActiveAmmoniumTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","ammonium","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport",".","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations","."),4295724). assertion_content_comment('tOboGo_HighAffinitySodium_DicarboxylateSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","dicarboxylate","(","out",")","+","Na","+","(","out",")","=","dicarboxylate","(","in",")","+","Na","+","(","in",")","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations","."),4295987). assertion_content_comment('tOboGo_HighAffinitySulfate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","sulfate","(","out",")","+","H","+","(","out",")","=","sulfate","(","in",")","+","H","+","(","in",")","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations","."),4260905). assertion_content_comment('tOboGo_HighAffinitySulfateTransmembraneTransporterActivity',s("Catalysis","of","the","secondary","active","high","affinity","transfer","of","sulfate","from","one","side","of","the","membrane","to","the","other",".","Secondary","active","transport","is","catalysis","of","the","transfer","of","a","solute","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport",".","In","high","affinity","transport","the","transporter","is","able","to","bind","thesolute","even","if","it","is","only","present","at","very","low","concentrations","."),4295800). assertion_content_comment('tOboGo_HighAffinityZincUptakeTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","Zn2","+","(","out",")","=","Zn2","+","(","in",")",",","probably","powered","by","proton","motive","force",".","In","high","affinity","transport","the","transporter","is","able","to","bind","the","solute","even","if","it","is","only","present","at","very","low","concentrations","."),4345434). assertion_content_comment('tOboGo_HighDensityLipoproteinParticleMediatedSignaling',s("A","series","of","molecular","signals","mediated","by","the","detection","of","high","density","lipoprotein","particle","."),4109432). assertion_content_comment('tOboGo_HighMobilityGroupBox1Binding',s("Interacting","selectively","and","non-covalently","with","high","mobility","group","box","1","(","HMBGB1",")"),4173578). assertion_content_comment('tOboGo_HighMobilityGroupBox1ReceptorActivity',s("Combining","with","high","mobility","group","box","1","(","HMBGB1",")","to","initiate","a","change","in","cell","activity","."),4173642). assertion_content_comment('tOboGo_HighMolecularWeightBCellGrowthFactorReceptorActivity',s("Combining","with","a","high","molecular","weight","B","cell","growth","factor","to","initiate","a","change","in","cell","activity","."),4309774). assertion_content_comment('tOboGo_HighMolecularWeightBCellGrowthFactorReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","high","molecular","weight","B","cell","growth","factor","receptor","."),4309786). assertion_content_comment('tOboGo_HighMolecularWeightKininogenBinding',s("Interacting","selectively","and","non-covalently","with","a","kininogen","of","high","molecular","mass","."),4307236). assertion_content_comment('tOboGo_HighMolecularWeightKininogenReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","high","molecular","weight","kininogen","receptor","."),4307207). assertion_content_comment('tOboGo_HighMolecularWeightKininogenReceptorComplex',s("A","protein","complex","that","acts","as","a","receptor","for","high","molecular","weight","kininogens",".","In","humans",",","this","receptor","includes","the","CK1","and","uPAR","proteins","."),4061120). assertion_content_comment('tOboGo_HindbrainDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","hindbrain","over","time",",","from","its","formation","to","the","mature","structure",".","The","hindbrain","is","the","posterior","of","the","three","primary","divisions","of","the","developing","chordate","brain",",","or","the","corresponding","part","of","the","adult","brain","(","in","vertebrates",",","includes","the","cerebellum",",","pons",",","and","medulla","oblongata","and","controls","the","autonomic","functions","and","equilibrium",")"),4041264). assertion_content_comment('tOboGo_HindbrainFormation',s("The","process","that","gives","rise","to","the","hindbrain",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","The","hindbrain","is","the","region","consisting","of","the","medulla",",","pons","and","cerebellum",".","Areas","of","the","hindbrain","control","motor","and","autonomic","functions","."),4042943). assertion_content_comment('tOboGo_HindbrainMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","hindbrain","to","attain","its","fully","functional","state",".","The","hindbrain","is","the","region","consisting","of","the","medulla",",","pons","and","cerebellum",".","Areas","of","the","hindbrain","control","motor","and","autonomic","functions","."),4042682). assertion_content_comment('tOboGo_HindbrainMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","hindbrain","is","generated","and","organized",".","The","hindbrain","is","the","region","consisting","of","the","medulla",",","pons","and","cerebellum",".","Areas","of","the","hindbrain","control","motor","and","autonomic","functions","."),4042908). assertion_content_comment('tOboGo_HindbrainRadialGliaGuidedCellMigration',s("The","radially","directed","movement","of","a","cell","along","radial","glial","cells","in","the","hindbrain",".","Radial","migration","refers","to","a","directed","movement","from","the","internal","ventricular","area","to","the","outer","surface","of","the","hindbrain","."),4047859). assertion_content_comment('tOboGo_HindbrainStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","hindbrain",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","The","hindbrain","is","the","region","consisting","of","the","medulla",",","pons","and","cerebellum",".","Areas","of","the","hindbrain","control","motor","and","autonomic","functions","."),4043228). assertion_content_comment('tOboGo_HindbrainTangentialCellMigration',s("The","migration","of","a","cell","in","the","hindbrain","in","which","cells","move","orthogonal","to","the","direction","of","radial","migration","."),4047823). assertion_content_comment('tOboGo_HindgutContraction',s("A","process","in","which","force","is","generated","within","smooth","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","This","process","occurs","in","the","hindgut",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","hindgut","is","the","posterior","part","of","the","alimentary","canal",",","including","the","rectum",",","and","the","large","intestine","."),4092838). assertion_content_comment('tOboGo_HindgutMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","hindgut","are","generated","and","organized","."),4017629). assertion_content_comment('tOboGo_HindlimbMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","hindlimb","are","generated","and","organized","."),4071699). assertion_content_comment('tOboGo_HippocampusDevelopment',s("The","progression","of","the","hippocampus","over","time","from","its","initial","formation","until","its","mature","state","."),4041143). assertion_content_comment('tOboGo_HippoSignalingCascade',s("The","series","of","molecular","signals","mediated","by","the","serine/threonine","kinase","Hippo","or","one","of","its","orthologs",".","In","Drosophila",",","Hippo","in","complex","with","the","scaffold","protein","Salvador","(","Sav",")",",","phosphorylates","and","activates","Warts","(","Wts",")",",","which","in","turn","phosphorylates","and","inactivates","the","Yorkie","(","Yki",")","transcriptional","activator",".","The","core","fly","components","hippo",",","sav",",","wts","and","mats","are","conserved","in","mammals","as","STK4/3","(","MST1/2",")",",","SAV1/WW45",",","LATS1/2","and","MOB1","."),4071327). assertion_content_comment('tOboGo_HippurateHydrolaseActivity',s("Catalysis","of","the","reaction",":","N-benzoylglycine","+","H","(","2",")","O","=","benzoate","+","glycine","."),4378832). assertion_content_comment('tOboGo_HIRComplex',s("A","protein","complex","proposed","to","be","involved","in","replication-independent","nucleosome","assembly",",","by","promoting","histone","deposition","onto","DNA",".","For","example",",","in","Saccharomyces",",","the","complex","contains","Hir1p",",","Hir2p",",","Hir3p",",","and","Hpc2p","."),4362547). assertion_content_comment('tOboGo_HistamineBinding',s("Interacting","selectively","and","non-covalently","with","histamine",",","a","physiologically","active","amine",",","found","in","plant","and","animal","tissue","and","released","from","mast","cells","as","part","of","an","allergic","reaction","in","humans","."),4286018). assertion_content_comment('tOboGo_HistamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","histamine",",","a","physiologically","active","amine",",","found","in","plant","and","animal","tissue","and","released","from","mast","cells","as","part","of","an","allergic","reaction","in","humans","."),4383777). assertion_content_comment('tOboGo_HistamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","histamine",",","a","physiologically","active","amine",",","found","in","plant","and","animal","tissue","and","released","from","mast","cells","as","part","of","an","allergic","reaction","in","humans","."),4383793). assertion_content_comment('tOboGo_HistamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","histamine",",","a","physiologically","active","amine",",","found","in","plant","and","animal","tissue","and","released","from","mast","cells","as","part","of","an","allergic","reaction","in","humans","."),4383772). assertion_content_comment('tOboGo_HistamineOxidaseActivity',s("Catalysis","of","the","reaction",":","histamine","+","H2O","+","O2","=","imidazole-4-acetaldehyde","+","NH3","+","hydrogen","peroxide","+","H","+"),4192217). assertion_content_comment('tOboGo_HistamineProductionInvolvedInInflammatoryResponse',s("The","synthesis","or","release","of","histamine","following","a","stimulus","as","part","of","an","inflammatory","response",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),3993581). assertion_content_comment('tOboGo_HistamineReceptorActivity',s("Combining","with","histamine","to","initiate","a","change","in","cell","activity",".","Histamine","is","a","physiologically","active","amine",",","found","in","plant","and","animal","tissue","and","released","from","mast","cells","as","part","of","an","allergic","reaction","in","humans","."),4197983). assertion_content_comment('tOboGo_HistamineSecretionByBasophil',s("The","regulated","release","of","histamine","by","a","basophil","or","group","of","basophils","."),3996471). assertion_content_comment('tOboGo_HistamineSecretionByMastCell',s("The","regulated","release","of","histamine","by","a","mast","cell","or","group","of","mast","cells","."),3996401). assertion_content_comment('tOboGo_HistamineSecretionByPlatelet',s("The","regulated","release","of","histamine","by","a","platelet","or","group","of","platelets","."),3996461). assertion_content_comment('tOboGo_HistamineSecretionInvolvedInInflammatoryResponse',s("The","regulated","release","of","histamine","by","a","cell","or","group","of","cells","as","part","of","an","inflammatory","response","."),3993612). assertion_content_comment('tOboGo_HistamineSecretion',s("The","regulated","release","of","histamine","by","a","cell","or","group","of","cells",".","It","is","formed","by","decarboxylation","of","histidine","and","it","acts","through","receptors","in","smooth","muscle","and","in","secretory","systems","."),3993608). assertion_content_comment('tOboGo_HistamineTransport',s("The","directed","movement","of","histamine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Histamine","is","a","physiologically","active","amine",",","found","in","plant","and","animal","tissue","and","released","from","mast","cells","as","part","of","an","allergic","reaction","in","humans","."),3993606). assertion_content_comment('tOboGo_HistamineUptake',s("The","directed","movement","of","histamine","into","a","cell",",","typically","presynaptic","neurons","or","glial","cells",".","Histamine","is","a","physiologically","active","amine",",","found","in","plant","and","animal","tissue","and","released","from","mast","cells","as","part","of","an","allergic","reaction","in","humans","."),4121685). assertion_content_comment('tOboGo_HistidineArginineLysineOrnithinePorterActivity',s("OBSOLETE",".","Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","polar","amino","acid","(","out",")","=","ADP","+","phosphate","+","polar","amino","acid","(","in",")"),4293662). assertion_content_comment('tOboGo_HistidineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","histidine",",","2-amino-3-","(","1H-imidazol-4-yl",")","propanoic","acid","."),4345889). assertion_content_comment('tOboGo_HistidineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","histidine",",","2-amino-3-","(","1H-imidazol-4-yl",")","propanoic","acid","."),4231487). assertion_content_comment('tOboGo_HistidineCatabolicProcessToGlutamateAndFormamide',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","histidine","into","other","compounds",",","including","glutamate","and","formamide","."),4242966). assertion_content_comment('tOboGo_HistidineCatabolicProcessToGlutamateAndFormate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","histidine","into","other","compounds",",","including","glutamate","and","formate","."),4242953). assertion_content_comment('tOboGo_HistidineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","L-histidine","=","histamine","+","CO2","."),4208144). assertion_content_comment('tOboGo_HistidineFamilyAminoAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","amino","acids","of","the","histidine","family","."),4257123). assertion_content_comment('tOboGo_HistidineFamilyAminoAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","amino","acids","of","the","histidine","family","."),4231481). assertion_content_comment('tOboGo_HistidineFamilyAminoAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","amino","acids","of","the","histidine","family","."),4231464). assertion_content_comment('tOboGo_Histidine_HistamineAntiporterActivity',s("Catalysis","of","the","reaction",":","histidine","(","out",")","+","histamine","(","in",")","=","histidine","(","in",")","+","histamine","(","out",")"),4178065). assertion_content_comment('tOboGo_HistidineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","histidine",",","2-amino-3-","(","1H-imidazol-4-yl",")","propanoic","acid","."),4231468). assertion_content_comment('tOboGo_HistidinePhosphotransferKinaseActivity',s("Serves","as","a","phospho-His","intermediate","enabling","the","transfer","of","phospho","group","between","a","hybrid","kinase","and","a","response","regulator","."),4261822). assertion_content_comment('tOboGo_HistidineTransport',s("The","directed","movement","of","histidine",",","2-amino-3-","(","1H-imidazol-4-yl",")","propanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293813). assertion_content_comment('tOboGo_HistidinolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-histidinol","+","NAD","+","=","L-histidine","+","NADH","+","H","+"),4208059). assertion_content_comment('tOboGo_HistoblastMorphogenesis',s("The","process","in","which","the","anatomical","structures","derived","from","the","histoblast","disc","are","generated","and","organized",".","This","includes","the","transformation","of","histoblast","cells","into","adult","structures","during","pupal","metamorphosis",".","Histoblast","cells","are","cells","founded","in","the","embryo","that","are","the","progenitors","to","the","adult","abdomen","."),4018177). assertion_content_comment('tOboGo_HistogenesisAndOrganogenesis',s("OBSOLETE",".","The","generation","of","organized","tissues","or","of","whole","organs","."),4234583). assertion_content_comment('tOboGo_Histolysis',s("The","breakdown","of","tissues",";","usually",",","if","not","always",",","accompanied","by","cell","death",",","followed","by","the","complete","dissolution","of","dead","tissue","."),4015439). assertion_content_comment('tOboGo_HistoneAcetylation',s("The","modification","of","a","histone","by","the","addition","of","an","acetyl","group","."),4072862). assertion_content_comment('tOboGo_HistoneAcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","histone","=","CoA","+","acetyl-histone","."),4206413). assertion_content_comment('tOboGo_HistoneAcetyltransferaseBinding',s("Interacting","selectively","and","non-covalently","with","the","enzyme","histone","acetyltransferase","."),4381776). assertion_content_comment('tOboGo_HistoneAcetyltransferaseComplex',s("A","protein","complex","that","possesses","histone","acetyltransferase","activity","."),4066470). assertion_content_comment('tOboGo_HistoneAcetyltransferaseRegulatorActivity',s("Modulates","the","activity","of","histone","acetyltransferase","."),4381766). assertion_content_comment('tOboGo_HistoneArginineDemethylation',s("The","modification","of","a","histone","by","the","removal","of","a","methyl","group","from","an","arginine","residue","."),4180172). assertion_content_comment('tOboGo_HistoneArginineKinaseActivity',s("Catalysis","of","the","reaction",":","histone","L-arginine","+","ATP","=","histone","N","(","omega",")","-phospho-L-arginine","+","ADP","+","2","H","(","+",")"),4285108). assertion_content_comment('tOboGo_HistoneArginineMethylation',s("The","modification","of","a","histone","by","addition","of","a","methyl","group","to","an","arginine","residue","."),4328468). assertion_content_comment('tOboGo_HistoneBinding',s("Interacting","selectively","and","non-covalently","with","a","histone",",","any","of","a","group","of","water-soluble","proteins","found","in","association","with","the","DNA","of","plant","and","animal","chromosomes",".","They","are","involved","in","the","condensation","and","coiling","of","chromosomes","during","cell","division","and","have","also","been","implicated","in","nonspecific","suppression","of","gene","activity","."),4175136). assertion_content_comment('tOboGo_HistoneBiotinylation',s("The","modification","of","a","histone","by","the","addition","of","a","biotinyl","group","."),4164440). assertion_content_comment('tOboGo_HistoneDeacetylaseActivity',s("Catalysis","of","the","reaction",":","histone","N6-acetyl-L-lysine","+","H2O","=","histone","L-lysine","+","acetate",".","This","reaction","represents","the","removal","of","an","acetyl","group","from","a","histone",",","a","class","of","proteins","complexed","to","DNA","in","chromatin","and","chromosomes","."),4206222). assertion_content_comment('tOboGo_HistoneDeacetylaseBinding',s("Interacting","selectively","and","non-covalently","with","the","enzyme","histone","deacetylase","."),4314832). assertion_content_comment('tOboGo_HistoneDeacetylaseComplex',s("A","protein","complex","that","possesses","histone","deacetylase","activity","."),4073175). assertion_content_comment('tOboGo_HistoneDeacetylaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","histone","deacetylase",",","which","catalyzes","of","the","removal","of","acetyl","groups","from","histones",",","proteins","complexed","to","DNA","in","chromatin","and","chromosomes","."),4357902). assertion_content_comment('tOboGo_HistoneDeacetylaseRegulatorActivity',s("Modulates","the","activity","of","histone","deacetylase","."),4357900). assertion_content_comment('tOboGo_HistoneDeacetylationAtCentromere',s("The","removal","of","acetyl","groups","from","histones","in","centromeric","DNA","."),4062739). assertion_content_comment('tOboGo_HistoneDeacetylation',s("The","modification","of","histones","by","removal","of","acetyl","groups","."),4062737). assertion_content_comment('tOboGo_HistoneDemethylaseActivity',s("Catalysis","of","the","removal","of","a","methyl","group","from","a","histone","."),4171539). assertion_content_comment('tOboGo_HistoneDemethylation',s("The","modification","of","histones","by","removal","of","methyl","groups","."),4171597). assertion_content_comment('tOboGo_HistoneDephosphorylation',s("The","modification","of","histones","by","removal","of","phosphate","groups","."),4305459). assertion_content_comment('tOboGo_HistoneDeubiquitination',s("The","modification","of","histones","by","removal","of","ubiquitin","groups","."),4174516). assertion_content_comment('tOboGo_HistoneExchange',s("The","replacement",",","within","chromatin",",","of","resident","histones","or","histone","subunits","with","alternative",",","sometimes","variant",",","histones","or","subunits","."),4072701). assertion_content_comment('tOboGo_HistoneH2AAcetylation',s("The","modification","of","histone","H2A","by","the","addition","of","an","acetyl","group","."),4328220). assertion_content_comment('tOboGo_HistoneH2AMonoubiquitination',s("The","modification","of","histone","H2A","by","addition","of","a","single","ubiquitin","group",".","Steady-state","modification","of","histone","H2A","occurs","at","lysine","119","(","H2A-K119",")","in","metazoans",",","and","at","the","equivalent","residue","in","other","organisms","."),4378979). assertion_content_comment('tOboGo_HistoneH2AUbiquitination',s("The","modification","of","histone","H2A","by","addition","of","one","or","more","ubiquitin","groups","."),4174427). assertion_content_comment('tOboGo_HistoneH2BAcetylation',s("The","modification","of","histone","H2B","by","the","addition","of","an","acetyl","group","."),4328239). assertion_content_comment('tOboGo_HistoneH2BUbiquitination',s("The","modification","of","histone","H2B","by","addition","of","ubiquitin","groups","."),4170666). assertion_content_comment('tOboGo_HistoneH3Acetylation',s("The","modification","of","histone","H3","by","the","addition","of","an","acetyl","group","."),4074334). assertion_content_comment('tOboGo_HistoneH3Deacetylation',s("The","modification","of","histone","H3","by","the","removal","of","one","or","more","acetyl","groups","."),4171170). assertion_content_comment('tOboGo_HistoneH4Acetylation',s("The","modification","of","histone","H4","by","the","addition","of","an","acetyl","group","."),4143525). assertion_content_comment('tOboGo_HistoneH4Deacetylation',s("The","modification","of","histone","H4","by","the","removal","of","one","or","more","acetyl","groups","."),4177917). assertion_content_comment('tOboGo_HistoneKinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group","to","a","histone",".","Histones","are","any","of","a","group","of","water-soluble","proteins","found","in","association","with","the","DNA","of","plant","and","animal","chromosomes","."),4159078). assertion_content_comment('tOboGo_HistoneLocusBody',s("A","nuclear","body","associated","with","the","histone","gene","locus","that","is","thought","to","contain","all","of","the","factors","necessary","for","histone","mRNA","transcription","and","pre-mRNA","processing",".","In","Drosophila",",","U7","snRNP","is","located","in","the","histone","locus","body","rather","than","the","distinct","Cajal","body","."),4383008). assertion_content_comment('tOboGo_HistoneLysineDemethylation',s("The","modification","of","a","histone","by","the","removal","of","a","methyl","group","from","a","lysine","residue","."),4171599). assertion_content_comment('tOboGo_HistoneLysineMethylation',s("The","modification","of","a","histone","by","addition","of","a","methyl","group","to","a","lysine","residue","."),3975561). assertion_content_comment('tOboGo_HistoneMethylation',s("The","modification","of","histones","by","addition","of","methyl","groups","."),3975559). assertion_content_comment('tOboGo_HistoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","histone","=","S-adenosyl-L-homocysteine","+","methyl-histone",".","Histone","methylation","generally","occurs","on","either","an","arginine","or","lysine","residue","."),4177093). assertion_content_comment('tOboGo_HistoneMethyltransferaseComplex',s("A","multimeric","complex","that","is","able","to","catalyze","the","addition","of","methyl","groups","to","histone","proteins","."),4162326). assertion_content_comment('tOboGo_HistoneModification',s("The","covalent","alteration","of","one","or","more","amino","acid","residues","within","a","histone","protein","."),3975557). assertion_content_comment('tOboGo_HistoneMonoubiquitination',s("The","modification","of","histones","by","addition","of","a","single","ubiquitin","group","."),4332138). assertion_content_comment('tOboGo_HistoneMRNACatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","histone","messenger","RNA","(","mRNA",")"),4167247). assertion_content_comment('tOboGo_HistoneMRNAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","an","mRNA","encoding","a","histone","."),4167244). assertion_content_comment('tOboGo_HistonePhosphorylation',s("The","modification","of","histones","by","addition","of","phosphate","groups","."),4065961). assertion_content_comment('tOboGo_HistoneSerineKinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group","to","a","serine","residue","of","a","histone",".","Histones","are","any","of","a","group","of","water-soluble","proteins","found","in","association","with","the","DNA","of","plant","and","animal","chromosomes","."),4159163). assertion_content_comment('tOboGo_HistoneThreonineKinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group","to","a","threonine","residue","of","a","histone",".","Histones","are","any","of","a","group","of","water-soluble","proteins","found","in","association","with","the","DNA","of","plant","and","animal","chromosomes","."),4159080). assertion_content_comment('tOboGo_HistoneTyrosineKinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group","to","a","tyrosine","residue","of","a","histone",".","Histones","are","any","of","a","group","of","water-soluble","proteins","found","in","association","with","the","DNA","of","plant","and","animal","chromosomes","."),4376101). assertion_content_comment('tOboGo_HistoneUbiquitination',s("The","modification","of","histones","by","addition","of","ubiquitin","groups","."),4065462). assertion_content_comment('tOboGo_HLHDomainBinding',s("Interacting","selectively","and","non-covalently","with","Helix","Loop","Helix",",","a","domain","of","40-50","residues","that","occurs","in","specific","DNA-binding","proteins","that","act","as","transcription","factors",".","The","domain","is","formed","of","two","amphipathic","helices","joined","by","a","variable","length","linker","region","that","can","form","a","loop","and","it","mediates","protein","dimerization","."),4318202). assertion_content_comment('tOboGo_HMGBoxDomainBinding',s("Interacting","selectively","and","non-covalently","with","an","HMG","box","domain",",","a","protein","domain","that","consists","of","three","helices","in","an","irregular","array",".","HMG-box","domains","are","found","in","one","or","more","copies","in","HMG-box","proteins",",","which","form","a","large",",","diverse","family","involved","in","the","regulation","of","DNA-dependent","processes","such","as","transcription",",","replication",",","and","strand","repair",",","all","of","which","require","the","bending","and","unwinding","of","chromatin","."),4170853). assertion_content_comment('tOboGo_HolinActivity',s("Catalysis","of","the","temporally-regulated","formation","of","a","transmembrane","protein","hole","that","directly","or","indirectly","allows","murein","hydrolyases","to","access","their","cell","wall","substrate","."),4360137). 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assertion_content_comment('tOboGo_HomeostasisOfNumberOfCells',s("Any","biological","process","involved","in","the","maintenance","of","the","steady-state","number","of","cells","within","a","population","of","cells","."),3984710). assertion_content_comment('tOboGo_HomeostasisOfNumberOfCellsWithinATissue',s("Any","biological","process","involved","in","the","maintenance","of","the","steady-state","number","of","cells","within","a","population","of","cells","in","a","tissue","."),4110852). assertion_content_comment('tOboGo_HomeostasisOfNumberOfMeristemCells',s("Any","biological","process","involved","in","the","maintenance","of","the","steady-state","number","of","cells","within","a","population","of","cells","in","the","meristem","."),4235063). 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assertion_content_comment('tOboGo_HomogalacturonanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","pectidic","homogalacturonan",",","characterized","by","a","backbone","of","1",",","4-linked","alpha-D-GalpA","residues","that","can","be","methyl-esterified","at","C-6","and","carry","acetyl","groups","on","O-2","and","O-3","."),4335179). assertion_content_comment('tOboGo_HomogalacturonanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","homogalacturonan",",","a","pectidic","polymer",",","characterized","by","a","backbone","of","1",",","4-linked","alpha-D-GalpA","residues","that","can","be","methyl-esterified","at","C-6","and","carry","acetyl","groups","on","O-2","and","O-3","."),4338554). assertion_content_comment('tOboGo_HomogalacturonanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","homogalacturonan",",","a","pectin","characterized","by","a","backbone","of","alpha-","(","1-","&","gt",";","4",")","-linked","D-galacturonic","acid","residues","that","can","be","methyl-esterified","at","C-6","and","carry","acetyl","groups","on","O-2","and","O-3","."),4332179). assertion_content_comment('tOboGo_HomogentisateFarnesyltransferaseActivity',s("Catalysis","of","the","reaction",":","homogentisic","acid","+","farnesyl","diphosphate","=","2-methyl-6-farnesylplastoquinol","."),4331966). assertion_content_comment('tOboGo_HomogentisateGeranylgeranyltransferaseActivity',s("Catalysis","of","the","reaction",":","homogentisic","acid","+","geranylgeranyl","diphosphate","=","2-methyl-6-geranylgeranylplastoquinol","."),4331984). assertion_content_comment('tOboGo_HomogentisatePhytyltransferaseActivity',s("Catalysis","of","the","reaction",":","homogentisate","+","phytyl","diphosphate","+","H","+","=","2-methyl-6-phytyl-1",",","4-benzoquinone","+","CO2","+","diphosphate",".","2-methyl-6-phytyl-1",",","4-benzoquinone","is","also","known","as","2-methyl-6-phytylplastoquinol","."),4334200). assertion_content_comment('tOboGo_HomogentisatePrenyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","prenyl","group","from","one","compound","(","donor",")","to","homogentisic","acid","."),4331964). assertion_content_comment('tOboGo_HomogentisateSolanesyltransferaseActivity',s("Catalysis","of","the","reaction",":","homogentisic","acid","+","all-trans-nonaprenyl","diphosphate","+","3","H","+","=","2-methyl-6-solanyl-1",",","4-benzoquinonone","+","CO2","+","diphosphate",".","2-methyl-6-solanyl-1",",","4-benzoquinonone","is","also","known","as","2-methyl-6-solanesylplastoquinol","and","all-trans-nonaprenyl","diphosphate","as","solanesyl","diphosphate","."),4331975). assertion_content_comment('tOboGo_HomoglutathioneSynthaseActivity',s("Catalysis","of","the","reaction",":","beta-alanine","+","L-gamma-glutamyl-L-cysteine","+","ATP","=","gamma-L-glutamyl-L-cysteinyl-beta-alanine","+","ADP","+","2","H","(","+",")","+","phosphate","."),4378922). assertion_content_comment('tOboGo_Homoiothermy',s("Any","homoeostatic","process","in","which","an","organism","maintains","its","internal","body","temperature","at","a","relatively","constant","value",".","This","is","achieved","by","using","metabolic","processes","to","counteract","fluctuations","in","the","temperature","of","the","environment","."),4233803). assertion_content_comment('tOboGo_HomoisocitrateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","+","+","3-carboxy-2-hydroxyadipate","=","NADH","+","H","+","+","CO2","+","2-keto-adipate","."),4364250). assertion_content_comment('tOboGo_HomologousChromosomeMovementTowardsSpindlePoleInvolvedInHomologousChromosomeSegregation',s("The","directed","movement","of","homologous","chromosomes","from","the","center","of","the","spindle","towards","the","spindle","poles",",","mediated","by","the","shortening","of","microtubules","attached","to","the","chromosomes",",","that","contributes","to","meiosis","I","."),4122200). assertion_content_comment('tOboGo_HomologousChromosomeOrientationInvolvedInMeioticMetaphaseIPlateCongression',s("The","cell","cycle","process","in","which","the","sister","centromeres","of","one","chromosome","attach","to","microtubules","that","emanate","from","the","same","spindle","pole",",","which","ensures","that","homologous","maternal","and","paternal","chromosomes","are","pulled","in","opposite","directions","at","anaphase","of","meiosis","I","."),4060075). assertion_content_comment('tOboGo_HomologousChromosomeSegregation',s("The","cell","cycle","process","in","which","replicated","homologous","chromosomes","are","organized","and","then","physically","separated","and","apportioned","to","two","sets","during","the","first","division","of","the","meiotic","cell","cycle",".","Each","replicated","chromosome",",","composed","of","two","sister","chromatids",",","aligns","at","the","cell","equator",",","paired","with","its","homologous","partner",";","this","pairing","off",",","referred","to","as","synapsis",",","permits","genetic","recombination",".","One","homolog","(","both","sister","chromatids",")","of","each","morphologic","type","goes","into","each","of","the","resulting","chromosome","sets","."),4060028). 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assertion_content_comment('tOboGo_HomoserineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","homoserine","from","one","side","of","a","membrane","to","the","other",".","Homoserine","is","alpha-amino-gamma-hydroxybutyric","acid",",","an","intermediate","in","the","biosynthesis","of","cystathionine",",","threonine","and","methionine","."),4316135). assertion_content_comment('tOboGo_HomoserineTransport',s("The","directed","movement","of","homoserine",",","alpha-amino-gamma-hydroxybutyric","acid",",","an","intermediate","in","the","biosynthesis","of","cystathionine",",","threonine","and","methionine",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4316220). assertion_content_comment('tOboGo_HomospermidineSynthaseActivity',s("Catalysis","of","the","reaction",":","2","putrescine","=","NH3","+","sym-homospermidine","."),4367655). assertion_content_comment('tOboGo_HomotetramericADPGPyrophosphorylaseComplex',s("A","protein","complex","composed","of","four","identical","subunits","that","possesses","ADPG","pyrophosphorylase","activity",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4307522). assertion_content_comment('tOboGo_HopanoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hopanoids",",","pentacyclic","sterol-like","compounds","based","on","the","hopane","nucleus","."),4244962). assertion_content_comment('tOboGo_HopanoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hopanoids",",","pentacyclic","sterol-like","compounds","based","on","the","hopane","nucleus","."),4244906). 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assertion_content_comment('tOboGo_HormonalRegulationOfTheForceOfHeartContraction',s("The","process","in","which","the","hormones","modulates","the","force","of","heart","muscle","contraction",".","A","hormone","is","one","of","a","group","of","substances","formed","in","very","small","amounts","in","one","specialized","organ","or","group","of","cells","and","carried","(","sometimes","in","the","bloodstream",")","to","another","organ","or","group","of","cells",",","in","the","same","organism",",","upon","which","they","have","a","specific","regulatory","action","."),4194057). 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assertion_content_comment('tOboGo_HostProgrammedCellDeathInducedBySymbiont',s("Cell","death","in","a","host","resulting","from","activation","of","host","endogenous","cellular","processes","after","direct","or","indirect","interaction","with","a","symbiont","(","defined","as","the","smaller","of","two",",","or","more",",","organisms","engaged","in","symbiosis",",","a","close","interaction","encompassing","mutualism","through","parasitism",")","An","example","of","direct","interaction","is","contact","with","penetrating","hyphae","of","a","fungus",";","an","example","of","indirect","interaction","is","encountering","symbiont-secreted","molecules","."),4031156). 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assertion_content_comment('tOboGo_Hrd1pUbiquitinLigaseComplex',s("A","multiprotein","complex","that","recognizes","and","ubiquitinates","proteins","with","misfolded","luminal","and","membrane","domains","during","ER-associated","protein","degradation","(","ERAD",")","In","S",".","cerevisiae",",","this","complex","contains","the","ubiquitin","ligase","Hrd1p","."),4363455). assertion_content_comment('tOboGo_Hsc70ProteinRegulatorActivity',s("OBSOLETE",".","Binds","to","and","modulates","the","activity","of","the","molecular","chaperone","Hsc70","."),4269466). assertion_content_comment('tOboGo_HslUVProteaseActivity',s("OBSOLETE",".","Catalysis","of","the","ATP-dependent","hydrolysis","of","peptide","bonds","in","substrates","including","E",".","coli","SulA","and","misfolded","proteins","."),4260094). assertion_content_comment('tOboGo_HslUVProteaseComplex',s("A","protein","complex","that","possesses","ATP-dependent","protease","activity",";","consists","of","an","ATPase","large","subunit","with","homology","to","other","Clp","family","ATPases","and","a","peptidase","small","subunit","related","to","the","proteasomal","beta-subunits","of","eukaryotes",".","In","the","E",".","coli","complex",",","six","identical","subunits","of","both","the","ATPase",",","ClpY",",","and","the","protease",",","ClpQ",",","self-assemble","into","an","oligomeric","ring",",","and","two","rings","of","each","subunit",",","two","ClpQ","rings","surrounded","by","single","ClpY","rings",",","form","a","dumbbell-shaped","complex","."),4260081). assertion_content_comment('tOboGo_Hsp27ProteinBinding',s("Interacting","selectively","and","non-covalently","with","Hsp27","proteins",",","a","lightweight","heat","shock","protein","."),4279220). assertion_content_comment('tOboGo_Hsp27ProteinInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","the","Hsp27","molecular","chaperone","."),4336187). assertion_content_comment('tOboGo_Hsp27ProteinRegulatorActivity',s("OBSOLETE",".","Modulates","the","activity","of","the","Hsp27","molecular","chaperone","."),4336173). assertion_content_comment('tOboGo_Hsp70Hsc70ProteinInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","chaperones","of","the","Hsp70/Hsc70","class","."),4311323). assertion_content_comment('tOboGo_Hsp70Hsc70ProteinRegulatorActivity',s("OBSOLETE",".","Modulates","the","activity","of","chaperones","of","the","Hsp70/Hsc70","class","."),4311310). assertion_content_comment('tOboGo_Hsp70Hsp90OrganizingProteinActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4247262). assertion_content_comment('tOboGo_Hsp70ProteinBinding',s("Interacting","selectively","and","non-covalently","with","Hsp70","proteins",",","any","of","a","group","of","heat","shock","proteins","around","70kDa","in","size","."),4310812). assertion_content_comment('tOboGo_Hsp90Deacetylation',s("The","modification","of","an","Hsp90","protein","by","removal","of","acetyl","groups","."),4178735). assertion_content_comment('tOboGo_Hsp90ProteinBinding',s("Interacting","selectively","and","non-covalently","with","Hsp90","proteins",",","any","of","a","group","of","heat","shock","proteins","around","90kDa","in","size","."),4282254). assertion_content_comment('tOboGo_Hsp90ProteinInhibitorActivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","the","Hsp90","molecular","chaperone","."),4336244). assertion_content_comment('tOboGo_Hsp90ProteinRegulatorActivity',s("OBSOLETE",".","Binds","to","and","modulates","the","activity","of","the","molecular","chaperone","Hsp90","."),4336230). assertion_content_comment('tOboGo_Hub1ActivatingEnzymeActivity',s("Catalysis","of","the","activation","of","the","small","ubiquitin-related","modifier","Hub1",",","through","the","formation","of","an","ATP-dependent","high-energy","thiolester","bond","."),4314126). assertion_content_comment('tOboGo_Hub1HydrolaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4314106). assertion_content_comment('tOboGo_HULCComplex',s("A","ubiquitin-conjugating","enzyme","complex","that","contains","two","RING","finger","proteins",",","which","have","ubiquitin","ligase","activity",",","in","addition","to","a","protein","with","ubiquitin-conjugating","enzyme","activity",";","catalyzes","the","ubiquitination","of","histone","H2B","at","lysine","119","(","or","the","equivalent","residue",")","In","Schizosaccharomyces","the","subunits","are","Rhp1",",","Brl2/Rfp1","and","Brl1/Rfp2","."),4063354). assertion_content_comment('tOboGo_HulleCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","Hulle","cells","over","time",",","from","their","formation","to","the","mature","structures",".","Hulle","cells","are","specialized","multinucleate","cells","that","originate","from","a","nest-like","aggregation","of","hyphae","during","sexual","development","and","serve","as","nurse","cells","to","the","developing","cleistothecium",",","or","fruiting","body","."),4132444). assertion_content_comment('tOboGo_HumoralDefenseMechanismSensuProtostomia',s("OBSOLETE",".","The","specific","immune","response","mediated","by","antibodies",".","As","in",",","but","not","restricted","to",",","the","taxon","Protostomia","(","Protostomia",",","ncbi_taxonomy_id",":","33317",")"),4303498). assertion_content_comment('tOboGo_HumoralImmuneResponseMediatedByCirculatingImmunoglobulin',s("An","immune","response","dependent","upon","secreted","immunoglobulin",".","An","example","of","this","process","is","found","in","Mus","musculus","."),3999740). assertion_content_comment('tOboGo_HumoralImmuneResponse',s("An","immune","response","mediated","through","a","body","fluid","."),3986091). assertion_content_comment('tOboGo_HyalineLayer',s("A","multilayered","extraembryonic","matrix","that","functions","as","a","substrate","for","cell","adhesion","through","early","development",".","It","is","thought","to","protect","and","lubricate","the","embryo",",","stabilize","the","blastomeres","during","morphogenesis",",","and","regulate","nutrient","intake",".","The","major","constituent","of","the","hyaline","layer","is","the","protein","hyalin",".","This","matrix","has","been","found","in","echinoderms","."),4067434). assertion_content_comment('tOboGo_HyaluronanBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hyaluronan",",","the","naturally","occurring","anionic","form","of","hyaluronic","acid",",","any","member","of","a","group","of","glycosaminoglycans",",","the","repeat","units","of","which","consist","of","beta-1",",","4","linked","D-glucuronyl-beta-","(","1",",","3",")","-N-acetyl-D-glucosamine","."),4311784). assertion_content_comment('tOboGo_HyaluronanCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hyaluronan",",","the","naturally","occurring","anionic","form","of","hyaluronic","acid",",","any","member","of","a","group","of","glycosaminoglycans",",","the","repeat","units","of","which","consist","of","beta-1",",","4","linked","D-glucuronyl-beta-","(","1",",","3",")","-N-acetyl-D-glucosamine","."),4311799). assertion_content_comment('tOboGo_HyaluronanMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hyaluronan",",","the","naturally","occurring","anionic","form","of","hyaluronic","acid",",","any","member","of","a","group","of","glycosaminoglycans",",","the","repeat","units","of","which","consist","of","beta-1",",","4","linked","D-glucuronyl-beta-","(","1",",","3",")","-N-acetyl-D-glucosamine","."),4311558). assertion_content_comment('tOboGo_HyaluronanSynthaseActivity',s("Catalysis","of","the","reaction",":","UDP-D-glucuronate","+","UDP-N-acetyl-D-glucosamine","=","[","beta-N-acetyl-D-glucosaminyl","(","1",",","4",")","beta-D-glucuronosyl","(","1",",","3",")","]","(","n",")","+","2n","UDP","."),4269687). assertion_content_comment('tOboGo_HyaluronateLyaseActivity',s("Catalysis","of","the","reaction",":","hyaluronate","=","n","3-","(","4-deoxy-beta-D-gluc-4-enuronosyl",")","-N-acetyl-D-glucosamine","."),4309628). assertion_content_comment('tOboGo_HyaluronicAcidBinding',s("Interacting","selectively","and","non-covalently","with","hyaluronic","acid",",","a","polymer","composed","of","repeating","dimeric","units","of","glucuronic","acid","and","N-acetyl","glucosamine","."),4218989). assertion_content_comment('tOboGo_HyaluronoglucuronidaseActivity',s("Catalysis","of","the","random","hydrolysis","of","1",",","3-linkages","between","beta-D-glucuronate","and","N-acetyl-D-glucosamine","residues","in","hyaluronate","."),4344099). assertion_content_comment('tOboGo_HyalurononglucosaminidaseActivity',s("Catalysis","of","the","random","hydrolysis","of","1",",","4-linkages","between","N-acetyl-beta-D-glucosamine","and","D-glucuronate","residues","in","hyaluronate","."),4206275). assertion_content_comment('tOboGo_Hydrogen_AminoAcidSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","amino","acid","(","out",")","+","H","+","(","out",")","=","amino","acid","(","in",")","+","H","+","(","in",")"),4215683). assertion_content_comment('tOboGo_HydrogenaseAcceptorActivity',s("Catalysis","of","the","reaction",":","H2","+","A","=","AH2","."),4342777). assertion_content_comment('tOboGo_HydrogenDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","H2","+","NAD","+","=","H","+","+","NADH","."),4378857). assertion_content_comment('tOboGo_HydrogenDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","NADP","+","+","H2","=","NADPH","+","H","+"),4267860). assertion_content_comment('tOboGo_Hydrogen_GlucoseSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","glucose","+","H","+","=","glucose","+","H","+","Symporter","activity","enables","the","active","transport","of","a","solute","across","a","membrane","by","a","mechanism","whereby","two","or","more","species","are","transported","together","in","the","same","direction","in","a","tightly","coupled","process","not","directly","linked","to","a","form","of","energy","other","than","chemiosmotic","energy","."),4216446). assertion_content_comment('tOboGo_HydrogenIonChannelActivity',s("Catalysis","of","facilitated","diffusion","of","a","hydrogen","ion","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel","without","evidence","for","a","carrier-mediated","mechanism","."),4295450). assertion_content_comment('tOboGo_HydrogenIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","hydrogen","ions","from","one","side","of","a","membrane","to","the","other","."),4185361). assertion_content_comment('tOboGo_HydrogenIonTransportingATPSynthaseActivityRotationalMechanism',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ADP","+","phosphate","=","ATP","+","H2O",",","coupled","with","transport","of","H","+","down","a","concentration","gradient",",","by","a","rotational","mechanism","."),4185917). assertion_content_comment('tOboGo_HydrogenosomalMembrane',s("The","lipid","bilayer","surrounding","a","hydrogenosome","."),4099673). assertion_content_comment('tOboGo_HydrogenosomeLumen',s("The","volume","enclosed","by","the","hydrogenosome","membrane","."),4074831). assertion_content_comment('tOboGo_Hydrogenosome',s("A","spherical",",","membrane-bounded","organelle","found","in","some","anaerobic","protozoa",",","which","participates","in","ATP","and","molecular","hydrogen","formation","."),4074820). assertion_content_comment('tOboGo_HydrogenPeroxideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hydrogen","peroxide","(","H2O2",")",",","a","potentially","harmful","byproduct","of","aerobic","cellular","respiration","which","can","cause","damage","to","DNA","."),4024419). assertion_content_comment('tOboGo_HydrogenPeroxideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hydrogen","peroxide","(","H2O2",")"),4139924). assertion_content_comment('tOboGo_HydrogenPeroxideMediatedSignalingPathway',s("A","series","of","molecular","signals","mediated","by","the","detection","of","hydrogen","peroxide","(","H2O2",")"),4171849). assertion_content_comment('tOboGo_HydrogenPeroxideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hydrogen","peroxide","(","H2O2",")",",","a","potentially","harmful","byproduct","of","aerobic","cellular","respiration","which","can","cause","damage","to","DNA","."),4024243). assertion_content_comment('tOboGo_HydrogenPeroxideTransmembraneTransport',s("The","process","in","which","hydrogen","peroxide","is","transported","from","one","side","of","a","membrane","to","the","other",".","This","process","includes","the","actual","movement","of","the","solute",",","and","any","regulation","and","preparatory","steps",",","such","as","reduction","of","the","solute","."),4181197). assertion_content_comment('tOboGo_Hydrogen_ProlineSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","proline","(","out",")","+","H","+","(","out",")","=","proline","(","in",")","+","H","+","(","in",")"),4215881). assertion_content_comment('tOboGo_Hydrogen_QuinoneOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","+","menaquinone","=","reduced","menaquinone","."),4364761). assertion_content_comment('tOboGo_HydrogenSulfideBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hydrogen","sulfide",",","H2S","."),4179051). assertion_content_comment('tOboGo_HydrogenSulfideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hydrogen","sulfide",",","H2S","."),4179038). assertion_content_comment('tOboGo_HydrogensulfiteReductaseActivity',s("Catalysis","of","the","reaction",":","trithionate","+","acceptor","+","2","H2O","+","OH-","=","3","HSO3-","+","reduced","acceptor","."),4278941). assertion_content_comment('tOboGo_HydrogenTransport',s("The","directed","movement","of","hydrogen","(","H2","or","H","+",")",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4031681). assertion_content_comment('tOboGo_HydrolaseActivityActingOnAcidAnhydridesActingOnGTPInvolvedInCellularAndSubcellularMovement',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","GTP","to","directly","drive","the","cellular","or","subcellular","transport","of","a","substance","."),4274124). assertion_content_comment('tOboGo_HydrolaseActivityActingOnAcidAnhydridesCatalyzingTransmembraneMovementOfSubstances',s("Catalysis","of","the","hydrolysis","of","an","acid","anhydride","to","directly","drive","the","transport","of","a","substance","across","a","membrane","."),4168938). assertion_content_comment('tOboGo_HydrolaseActivityActingOnAcidAnhydridesInvolvedInCellularAndSubcellularMovement',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4301666). assertion_content_comment('tOboGo_HydrolaseActivityActingOnAcidAnhydrides',s("Catalysis","of","the","hydrolysis","of","any","acid","anhydride","."),4159546). assertion_content_comment('tOboGo_HydrolaseActivityActingOnAcidHalideBonds',s("Catalysis","of","the","hydrolysis","of","any","acid","halide","bond","."),4237252). assertion_content_comment('tOboGo_HydrolaseActivityActingOnEsterBonds',s("Catalysis","of","the","hydrolysis","of","any","ester","bond","."),4164391). assertion_content_comment('tOboGo_HydrolaseActivityActingOnEtherBonds',s("Catalysis","of","the","hydrolysis","of","any","ether","or","thioether","bond",",","-O-","or","-S-","respectively","."),4205809). assertion_content_comment('tOboGo_HydrolaseActivityActingOnGlycosylBonds',s("Catalysis","of","the","hydrolysis","of","any","glycosyl","bond","."),4157585). assertion_content_comment('tOboGo_HydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","various","bonds",",","e.g",".","C-O",",","C-N",",","C-C",",","phosphoric","anhydride","bonds",",","etc",".","Hydrolase","is","the","systematic","name","for","any","enzyme","of","EC","class","3","."),4157583). assertion_content_comment('tOboGo_HydrolyticDNADemethylation',s("The","hydrolytic","removal","of","the","methyl","group","from","one","or","more","nucleotides","within","a","DNA","molecule","."),4379247). assertion_content_comment('tOboGo_HydroperoxideDehydrataseActivity',s("Catalysis","of","the","reaction",":","(","9Z",",","11E",",","14Z",")","-","(","13S",")","-hydroperoxyoctadeca-9",",","11",",","14-trienoate","=","(","9Z",")","-","(","13S",")","-12",",","13-epoxyoctadeca-9",",","11-dienoate","+","H2O","."),4378883). assertion_content_comment('tOboGo_HydroperoxideReductaseActivity',s("Catalysis","of","the","reaction",":","2","RSH","+","ROOH","=","RSSR","+","ROH","+","H2O",".","This","reaction","is","the","thiol-dependent","conversion","of","an","organic","hydroperoxide","to","the","corresponding","alcohol","."),4337265). assertion_content_comment('tOboGo_HydrophobicUncoupler_HydrogenAntiporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","hydrophobic","uncoupler","(","in",")","+","H","+","(","out",")","=","hydrophobic","uncoupler","(","out",")","+","H","+","(","in",")","Hydrophobic","uncouplers","include","CCCP",",","benzalkonium","and","SDS","."),4292865). assertion_content_comment('tOboGo_HydroquinoneGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","hydroquinone","+","UDP-D-glucose","=","H","(","+",")","+","hydroquinone","O-beta-D-glucopyranoside","+","UDP","."),4269636). assertion_content_comment('tOboGo_Hydrotropism',s("Growth","or","movement","in","a","sessile","organism","toward","or","away","from","water",",","as","of","the","roots","of","a","plant","."),4335252). assertion_content_comment('tOboGo_HydroxyacylglutathioneHydrolaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-","(","2-hydroxyacyl",")","glutathione","+","H2O","=","glutathione","+","a","2-hydroxy","carboxylate","."),4206261). assertion_content_comment('tOboGo_HydroxyaminoBenzeneMutaseActivity',s("Catalysis","of","the","reaction",":","(","hydroxyamino",")","benzene","=","2-aminophenol","."),4273621). assertion_content_comment('tOboGo_HydroxyanthraquinoneGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","a","hydroxyanthraquinone","+","UDP-D-glucose","=","a","glucosyloxyanthraquinone","+","UDP","."),4366873). assertion_content_comment('tOboGo_HydroxyapatiteBinding',s("Interacting","selectively","and","non-covalently","with","hydroxyapatite",",","the","calcium","phosphate","mineral","of","formula","Ca10","(","PO4",")","6","(","OH",")","2","found","both","in","rocks","of","nonorganic","origin","and","as","a","component","of","bone","and","dentine","."),4358166). assertion_content_comment('tOboGo_HydroxyAromaticAminoAcidPermeaseActivity',s("OBSOLETE",".","Permease","for","hydroxy","and","aromatic","amino","acids","."),4292712). assertion_content_comment('tOboGo_HydroxycinnamoyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","hydroxycinnamoyl","group","to","an","acceptor","molecule","."),4275791). assertion_content_comment('tOboGo_HydroxycyclohexanecarboxylateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","1S",",","3R",",","4S",")","-3",",","4-dihydroxycyclohexane-1-carboxylate","+","NAD","(","+",")","=","(","1S",",","4S",")","-4-hydroxy-3-oxocyclohexane-1-carboxylate","+","H","(","+",")","+","NADH","."),4364052). assertion_content_comment('tOboGo_HydroxydechloroatrazineEthylaminohydrolaseActivity',s("Catalysis","of","the","reaction",":","4-","(","ethylamino",")","-2-hydroxy-6-","(","isopropylamino",")","-1",",","3",",","5-triazine","+","H2O","=","N-isopropylammelide","+","ethylamine","."),4274585). assertion_content_comment('tOboGo_HydroxyectoineBinding',s("Interacting","selectively","and","non-covalently","with","hydroxyectoine","."),4338336). assertion_content_comment('tOboGo_HydroxyectoineTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","hydroxyectoine","from","one","side","of","the","membrane","to","the","other","."),4337836). assertion_content_comment('tOboGo_HydroxyectoineTransport',s("The","directed","movement","of","hydroxyectoine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4338969). assertion_content_comment('tOboGo_HydroxyethylthiazoleKinaseActivity',s("Catalysis","of","the","reaction",":","5-","(","2-hydroxyethyl",")","-4-methylthiazole","+","ATP","=","4-methyl-5-","(","2-phosphoethyl",")","-thiazole","+","ADP","+","2","H","(","+",")"),4206248). assertion_content_comment('tOboGo_HydroxyglutamateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxy-L-glutamate","+","H","(","+",")","=","4-amino-3-hydroxybutanoate","+","CO","(","2",")"),4379011). assertion_content_comment('tOboGo_HydroxyisourateHydrolaseActivity',s("Catalysis","of","the","reaction",":","5-hydroxyisourate","+","H","(","2",")","O","=","5-hydroxy-2-oxo-4-ureido-2",",","5-dihydro-1H-imidazole-5-carboxylate","+","H","(","+",")"),4345067). assertion_content_comment('tOboGo_HydroxyjasmonateSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","a","hydroxyjasmonate","+","phosphoadenosine-5","'","-phosphosulfate","=","a","hydroxyjasmonate","sulfate","+","adenosine-3","'",",","5","'","-bisphosphate","."),4180934). assertion_content_comment('tOboGo_HydroxylamineOxidaseActivity',s("Catalysis","of","the","reaction",":","hydroxylamine","+","O","(","2",")","=","H","(","2",")","O","+","H","(","+",")","+","nitrite","."),4378999). assertion_content_comment('tOboGo_HydroxylamineOxidoreductaseActivity',s("Catalysis","of","the","reactions",":","hydroxylamine","+","NH3","=","hydrazine","+","H2O",",","and","hydrazine","+","acceptor","=","N2","+","reduced","acceptor","."),4342487). assertion_content_comment('tOboGo_HydroxylamineReductaseActivity',s("Catalysis","of","the","reaction",":","NH3","+","H2O","+","acceptor","=","hydroxylamine","+","reduced","acceptor","."),4266570). assertion_content_comment('tOboGo_HydroxylamineReductaseNADHActivity',s("Catalysis","of","the","reaction",":","NH3","+","NAD","+","+","H2O","=","hydroxylamine","+","NADH","+","H","+"),4265964). assertion_content_comment('tOboGo_HydroxylysineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hydroxylysine","(","5-hydroxy-2",",","6-diaminohexanoic","acid",")",",","a","chiral","alpha-amino","acid","."),4362041). assertion_content_comment('tOboGo_HydroxylysineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hydroxylysine","(","5-hydroxy-2",",","6-diaminohexanoic","acid",")",",","a","chiral","alpha-amino","acid","."),4362107). assertion_content_comment('tOboGo_HydroxylysineKinaseActivity',s("Catalysis","of","the","reaction",":","erythro-5-hydroxy-L-lysine","+","GTP","=","5-phosphonooxy-L-lysine","+","GDP","+","2","H","(","+",")"),4379129). assertion_content_comment('tOboGo_HydroxylysineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hydroxylysine","(","5-hydroxy-2",",","6-diaminohexanoic","acid",")",",","a","chiral","alpha-amino","acid",".","Hydroxylysine","is","found","in","collagen","and","commonly","has","galactose","and","then","glucose","added","sequentially","by","glycosyltransferases","."),4362038). assertion_content_comment('tOboGo_HydroxymalonateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","hydroxymalonate","+","NAD","(","+",")","=","H","(","+",")","+","NADH","+","oxomalonate","."),4379103). assertion_content_comment('tOboGo_HydroxymandelonitrileGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxymandelonitrile","+","UDP-D-glucose","=","H","(","+",")","+","taxiphyllin","+","UDP","."),4366886). assertion_content_comment('tOboGo_HydroxymandelonitrileLyaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxymandelonitrile","=","4-hydroxybenzaldehyde","+","hydrocyanate","."),4266541). assertion_content_comment('tOboGo_HydroxymethylbilaneSynthaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","4","porphobilinogen","=","hydroxymethylbilane","+","4","NH","(","4",")","(","+",")"),4206674). assertion_content_comment('tOboGo_HydroxymethylbutenylPyrophosphateReductaseActivity',s("Catalysis","of","the","formation","of","both","isopentenyl","pyrophosphate","and","dimethylallyl","pyrophosphate","from","(","E",")","-4-hydroxy-3-methyl-but-2-enyl","pyrophosphate","."),4312838). assertion_content_comment('tOboGo_HydroxymethylfurfuralReductaseActivity',s("Catalysis","of","the","reaction",":","5-hydroxymethylfurfural","+","NAD","(","P",")","H","+","H","+","=","2",",","5-bis-hydroxymethylfuran","+","NAD","(","P",")","+"),4342396). assertion_content_comment('tOboGo_HydroxymethylfurfuralReductaseNADHActivity',s("Catalysis","of","the","reaction",":","5-hydroxymethylfurfural","+","NADH","+","H","+","=","2",",","5-bis-hydroxymethylfuran","+","NAD","+"),4343388). assertion_content_comment('tOboGo_HydroxymethylfurfuralReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","5-hydroxymethylfurfural","+","NADPH","+","H","+","=","2",",","5-bis-hydroxymethylfuran","+","NADP","+"),4343887). assertion_content_comment('tOboGo_HydroxymethylmethylsilanediolOxidaseActivity',s("Catalysis","of","the","reaction",":","hydroxymethylmethylsilanediol","+","O2","+","2","H","+","+","2","e-","=","formylmethylsilanediol","+","2","H2O","."),4281676). assertion_content_comment('tOboGo_HydroxymethylpyrimidineKinaseActivity',s("Catalysis","of","the","reaction",":","4-amino-5-hydroxymethyl-2-methylpyrimidine","+","ATP","=","4-amino-2-methyl-5-phosphomethylpyrimidine","+","ADP","+","2","H","(","+",")"),4248319). assertion_content_comment('tOboGo_HydroxymethylsilanetriolOxidaseActivity',s("Catalysis","of","the","reaction",":","hydroxymethylsilanetriol","+","O2","+","2","H","+","+","2","e-","=","2","H2O","+","formylsilanetriol","."),4275607). assertion_content_comment('tOboGo_HydroxymonomethylisoproturonDimethylaminedehydrogenaseActivity',s("Catalysis","of","the","reaction",":","hydroxymonodemethylisoproturon","+","H2O","=","formaldehyde","+","4","'","-","(","2-hydroxyisopropyl",")","phenylurea","+","2","H","+","+","2","e-","."),4352624). assertion_content_comment('tOboGo_HydroxynitrilaseActivity',s("Catalysis","of","the","reaction",":","a","hydroxynitrile","=","cyanide","+","an","aldehyde","or","ketone","."),4266529). assertion_content_comment('tOboGo_HydroxyphenylpyruvateReductaseActivity',s("Catalysis","of","the","reaction",":","3-","(","4-hydroxyphenyl",")","lactate","+","NAD","+","=","3-","(","4-hydroxyphenyl",")","pyruvate","+","NADH","."),4379056). assertion_content_comment('tOboGo_HydroxyphytanateOxidaseActivity',s("Catalysis","of","the","reaction",":","(","2S",")","-2-hydroxyphytanate","+","O","(","2",")","=","2-oxophytanate","+","H","(","2",")","O","(","2",")"),4379179). assertion_content_comment('tOboGo_HydroxyprolineTransport',s("The","directed","movement","of","hydroxyproline","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4352325). assertion_content_comment('tOboGo_HydroxypyruvateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxypyruvate","+","H","(","+",")","=","CO","(","2",")","+","glycolaldehyde","."),4379168). assertion_content_comment('tOboGo_HydroxypyruvateIsomeraseActivity',s("Catalysis","of","the","reaction",":","3-hydroxypyruvate","=","2-hydroxy-3-oxopropanoate","."),4248331). assertion_content_comment('tOboGo_HydroxypyruvateReductaseActivity',s("Catalysis","of","the","reaction",":","D-glycerate","+","NADP","+","=","hydroxypyruvate","+","NADPH","+","H","+"),4305891). assertion_content_comment('tOboGo_HypermethylationOfCpGIsland',s("An","increase","in","the","epigenetic","methylation","of","cytosine","and","adenosine","residues","in","a","CpG","island","in","DNA",".","CpG","islands","are","genomic","regions","that","contain","a","high","frequency","of","the","CG","dinucleotide","and","are","often","associated","with","the","transcription","start","site","of","genes","."),4288919). assertion_content_comment('tOboGo_HyperosmoticResponse',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","or","cell","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","detection","of",",","or","exposure","to",",","a","hyperosmotic","environment",",","i.e",".","an","environment","with","a","higher","concentration","of","solutes","than","the","organism","or","cell","."),4011259). assertion_content_comment('tOboGo_HyperosmoticSalinityResponse',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","or","cell","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","detection","of",",","or","exposure","to",",","an","increase","in","the","concentration","of","salt","(","particularly","but","not","exclusively","sodium","and","chloride","ions",")","in","the","environment","."),4163443). assertion_content_comment('tOboGo_Hyperphosphorylation',s("OBSOLETE",".","The","excessive","phosphorylation","of","a","protein",",","as","a","result","of","activation","of","kinases",",","deactivation","of","phosphatases",",","or","both","."),4385235). assertion_content_comment('tOboGo_Hypersensitivity',s("An","inflammatory","response","to","an","exogenous","environmental","antigen","or","an","endogenous","antigen","initiated","by","the","adaptive","immune","system","."),3982916). assertion_content_comment('tOboGo_HyphalCellWall',s("The","cell","wall","surrounding","a","fungal","hypha","."),4310072). assertion_content_comment('tOboGo_HyphalGrowth',s("Growth","of","fungi","as","threadlike",",","tubular","structures","that","may","contain","multiple","nuclei","and","may","or","may","not","be","divided","internally","by","septa",",","or","cross-walls","."),4310103). assertion_content_comment('tOboGo_HyphalSeptinBand',s("A","septin","band",",","i.e",".","a","diffuse","ring","composed","of","a","series","of","septin","bars","running","parallel","to","the","long","axis","of","the","cell",",","located","at","the","junction","between","the","mother","cell","and","the","germ","tube","(","hypha",")","of","a","fungal","cell","growing","filamentously","."),4329478). assertion_content_comment('tOboGo_HyphalSeptinCap',s("A","faint","structure","formed","of","septins","found","at","the","leading","edge","of","growth","in","hyphae","of","fungal","cells","growing","filamentously",".","This","cap","of","septins","colocalizes","with","a","region","of","the","plasma","membrane","that","is","rich","in","ergosterol","."),4329469). assertion_content_comment('tOboGo_HyphalSeptinRing',s("A","tight","ring-shaped","structure","that","forms","in","the","division","plane","within","hyphae","of","filamentous","fungi","at","sites","where","a","septum","will","form",";","composed","of","septins","as","well","as","septin-associated","proteins","."),4329450). assertion_content_comment('tOboGo_HyphalTipPolarisome',s("Protein","complex","that","has","a","role","in","determining","cell","polarity",",","found","at","the","tip","of","a","growing","fungal","hypha","."),4060450). assertion_content_comment('tOboGo_HyphalTip',s("The","end",",","or","tip",",","of","a","fungal","hypha",",","where","polarized","growth","occurs","during","hyphal","elongation","."),4060440). assertion_content_comment('tOboGo_HyphopodiumFormationOnOrNearHost',s("The","process","in","which","a","specialized","structure",",","consisted","of","stalked",",","thick-walled",",","lobed","cells","of","vegetative","epiphytic","hyphae",",","is","formed",",","to","attach","and","penetrate","the","host","surface",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146611). assertion_content_comment('tOboGo_HypoblastDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","hypoblast","over","time",",","from","its","formation","to","the","mature","structure",".","The","hypoblast","is","a","tissue","formed","from","the","inner","cell","mass","that","lies","beneath","the","epiblast","and","gives","rise","to","extraembryonic","endoderm","."),4154840). assertion_content_comment('tOboGo_HypochlorousAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hypochlorous","acid","."),4375384). assertion_content_comment('tOboGo_HypochlorousAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hypochlorous","acid","."),4375298). assertion_content_comment('tOboGo_HypochlorousAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hypochlorous","acid","."),4375291). assertion_content_comment('tOboGo_HypochordDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","hypochord","over","time",",","from","its","formation","to","the","mature","structure",".","The","hypochord","is","a","transient","rod-like","structure","in","the","embryos","of","fish",",","lampreys","and","amphibians","that","is","located","immediately","ventral","to","the","notochord",".","The","hypochord","may","play","a","role","in","positioning","the","dorsal","aorta","."),4222051). assertion_content_comment('tOboGo_HypocretinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","hypocretin","receptor","."),4312848). assertion_content_comment('tOboGo_HypoglossalNerveDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","hypoglossal","nerve","over","time",",","from","its","formation","to","the","mature","structure",".","This","motor","nerve","innervates","all","the","intrinsic","and","all","but","one","of","the","extrinsic","muscles","of","the","tongue","."),4044296). assertion_content_comment('tOboGo_HypoglossalNerveFormation',s("The","process","that","gives","rise","to","the","hypoglossal","nerve",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts",".","This","motor","nerve","innervates","all","the","intrinsic","and","all","but","one","of","the","extrinsic","muscles","of","the","tongue","."),4044313). assertion_content_comment('tOboGo_HypoglossalNerveMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","hypoglossal","nerve","to","attain","its","fully","functional","state",".","This","motor","nerve","innervates","all","the","intrinsic","and","all","but","one","of","the","extrinsic","muscles","of","the","tongue","."),4044326). assertion_content_comment('tOboGo_HypoglossalNerveMorphogenesis',s("The","process","in","which","the","anatomical","structure","of","the","hypoglossal","nerve","is","generated","and","organized",".","This","motor","nerve","innervates","all","the","intrinsic","and","all","but","one","of","the","extrinsic","muscles","of","the","tongue","."),4044301). assertion_content_comment('tOboGo_HypoglossalNerveStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","hypoglossal","nerve",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure",".","This","motor","nerve","innervates","all","the","intrinsic","and","all","but","one","of","the","extrinsic","muscles","of","the","tongue","."),4044389). assertion_content_comment('tOboGo_HypoglossalNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","hypoglossal","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042832). assertion_content_comment('tOboGo_HypomethylationOfCpGIsland',s("An","decrease","in","the","epigenetic","methylation","of","cytosine","and","adenosine","residues","in","a","CpG","island","in","DNA",".","CpG","islands","are","genomic","regions","that","contain","a","high","frequency","of","the","CG","dinucleotide","and","are","often","associated","with","the","transcription","start","site","of","genes","."),4288878). assertion_content_comment('tOboGo_HyponitriteReductaseActivity',s("Catalysis","of","the","reaction",":","2","hydroxylamine","+","2","NAD","(","+",")","=","2","H","(","+",")","+","hyponitrous","acid","+","2","NADH","."),4379141). assertion_content_comment('tOboGo_HypophosphiteDioxygenaseActivity',s("Catalysis","of","the","reaction",":","hypophosphite","+","2-oxoglutarate","+","O2","=","succinate","+","phosphite","+","CO2","."),4349952). assertion_content_comment('tOboGo_HypophysisFormation',s("The","process","in","which","the","anatomical","structures","of","the","hypophysis","are","generated","and","organized",".","The","hypophysis","is","an","endocrine","gland","that","secretes","hormones","that","regulate","many","other","glands","."),4105652). assertion_content_comment('tOboGo_HypophysisMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","hypophysis","are","generated","and","organized",".","The","pituitary","gland","is","an","endocrine","gland","that","secretes","hormones","that","regulate","many","other","glands","."),4105627). assertion_content_comment('tOboGo_HypotaurineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","hypotaurine","+","NAD","(","+",")","=","H","(","+",")","+","NADH","+","taurine","."),4375150). assertion_content_comment('tOboGo_HypotaurocyamineKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","hypotaurocyamine","=","N","(","omega",")","-phosphohypotaurocyamine","+","ADP","+","2","H","(","+",")"),4374255). assertion_content_comment('tOboGo_HypothalamusCellDifferentiation',s("The","differentiation","of","cells","that","will","contribute","to","the","structure","and","function","of","the","hypothalamus","."),4047608). assertion_content_comment('tOboGo_HypothalamusCellMigration',s("The","directed","movement","of","a","cell","into","the","hypothalamus","region","of","the","forebrain","."),4050693). assertion_content_comment('tOboGo_HypothalamusDevelopment',s("The","progression","of","the","hypothalamus","region","of","the","forebrain",",","from","its","initial","formation","to","its","mature","state","."),4047606). assertion_content_comment('tOboGo_HypotonicResponse',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","or","cell","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","detection","of",",","or","exposure","to",",","a","hypotonic","environment",",","i.e",".","an","environment","with","a","lower","concentration","of","solutes","than","the","organism","or","cell","."),4163392). assertion_content_comment('tOboGo_HypotonicSalinityResponse',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","or","cell","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","detection","of",",","or","exposure","to",",","a","decrease","in","the","concentration","of","salt","(","particularly","but","not","exclusively","sodium","and","chloride","ions",")","in","the","environment","."),4163396). assertion_content_comment('tOboGo_HypoxanthineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","hypoxanthine",",","6-hydroxy","purine",",","an","intermediate","in","the","degradation","of","adenylate",".","Its","ribonucleoside","is","known","as","inosine","and","its","ribonucleotide","as","inosinate","."),4317685). assertion_content_comment('tOboGo_HypoxanthineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hypoxanthine",",","6-hydroxy","purine",",","an","intermediate","in","the","degradation","of","adenylate",".","Its","ribonucleoside","is","known","as","inosine","and","its","ribonucleotide","as","inosinate","."),4228145). assertion_content_comment('tOboGo_HypoxanthineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","hypoxanthine","+","NAD","+","+","H2O","=","xanthine","+","NADH","+","H","+"),4177428). assertion_content_comment('tOboGo_HypoxanthineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hypoxanthine",",","6-hydroxy","purine",",","an","intermediate","in","the","degradation","of","adenylate",".","Its","ribonucleoside","is","known","as","inosine","and","its","ribonucleotide","as","inosinate","."),4228142). assertion_content_comment('tOboGo_HypoxanthineOxidaseActivity',s("Catalysis","of","the","reaction",":","hypoxanthine","+","H2O","+","O2","=","xanthine","+","H2O2","."),4177391). assertion_content_comment('tOboGo_HypoxanthineOxidation',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","hypoxanthine","to","xanthine","and","thence","to","uric","acid","."),4228151). assertion_content_comment('tOboGo_HypoxanthinePhosphoribosyltransferaseActivity',s("Catalysis","of","the","reaction",":","IMP","+","diphosphate","=","hypoxanthine","+","5-phospho-alpha-D-ribose","1-diphosphate","."),4206732). assertion_content_comment('tOboGo_HypoxanthineSalvage',s("Any","process","that","generates","hypoxanthine",",","6-hydroxy","purine",",","from","derivatives","of","it","without","de","novo","synthesis","."),4317691). assertion_content_comment('tOboGo_HypoxanthineTransport',s("The","directed","movement","of","hypoxanthine",",","6-hydroxypurine",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4083480). assertion_content_comment('tOboGo_HypusineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","hypusine",",","N6-","(","4-amino-2-hydroxybutyl",")","-L-lysine","."),4210925). assertion_content_comment('tOboGo_HZone',s("A","relatively","pale","zone","traversing","the","center","of","the","A","band","of","a","sarcomere",",","visible","in","relaxed","muscle","fibers",";","consists","of","the","central","portion","of","thick","(","myosin",")","filaments","that","are","not","overlapped","by","thin","(","actin",")","filaments","."),4056864). assertion_content_comment('tOboGo_IBand',s("A","region","of","a","sarcomere","that","appears","as","a","light","band","on","each","side","of","the","Z","disc",",","comprising","a","region","of","the","sarcomere","where","thin","(","actin",")","filaments","are","not","overlapped","by","thick","(","myosin",")","filaments",";","contains","actin",",","troponin",",","and","tropomyosin",";","each","sarcomere","includes","half","of","an","I","band","at","each","end","."),4052662). assertion_content_comment('tOboGo_IceBinding',s("Interacting","selectively","and","non-covalently","with","ice",",","water","reduced","to","the","solid","state","by","cold","temperature",".","It","is","a","white","or","transparent","colorless","substance",",","crystalline",",","brittle",",","and","viscoidal","."),4233828). assertion_content_comment('tOboGo_IceNucleationActivity',s("OBSOLETE",".","Catalysis","of","the","formation","of","ice","crystals","in","extracellular","fluid","at","relatively","high","temperatures","(","up","to","-2","degrees","C",")","to","protect","the","organism","from","damage","by","intracellular","ice","formation",".","Ice","nucleation","proteins","function","by","binding","an","ice","crystal","and","then","encouraging","it","to","form","larger","crystals",".","Ice","nucleation","is","a","chemical","process","but","these","proteins","can","positively","regulate","it",".","There","are","two","different","uses","of","ice","nucleation","proteins",":","bacteria","secrete","them","extracellularly","to","cause","a","host","organism","'","s","cells","to","freeze","and","die",",","and","fish","use","them","to","protect","themselves","from","intracellular","ice","formation","."),4233835). assertion_content_comment('tOboGo_IceNucleationInhibitorActivity',s("OBSOLETE",".","Inhibits","the","formation","of","ice","crystals","."),4304066). assertion_content_comment('tOboGo_IcosahedralViralCapsid',s("The","protein","coat","that","surrounds","the","infective","nucleic","acid","in","some","virus","particles",";","the","subunits","are","arranged","to","form","an","icosahedron",",","a","solid","with","20","faces","and","12","vertices",".","Tobacco","satellite","necrosis","virus","has","such","a","capsid","structure","."),4237018). assertion_content_comment('tOboGo_IcosanoidBinding',s("Interacting","selectively","and","non-covalently","with","icosanoids",",","any","C20","polyunsaturated","fatty","acids","or","their","derivatives",",","including","the","leukotrienes","and","the","prostanoids","."),4268883). assertion_content_comment('tOboGo_IcosanoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","icosanoids",",","any","of","a","group","of","C20","polyunsaturated","fatty","acids","."),4045782). assertion_content_comment('tOboGo_IcosanoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","icosanoids",",","any","of","a","group","of","C20","polyunsaturated","fatty","acids","."),4045719). assertion_content_comment('tOboGo_IcosanoidReceptorActivity',s("Combining","with","an","icosanoid","to","initiate","a","change","in","cell","activity","."),4197779). assertion_content_comment('tOboGo_IcosanoidSecretion',s("The","controlled","release","of","icosanoids",",","any","of","a","group","of","C20","polyunsaturated","fatty","acids","."),4054650). assertion_content_comment('tOboGo_IcosanoidTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","icosanoids","from","one","side","of","the","membrane","to","the","other","."),4170127). assertion_content_comment('tOboGo_IcosanoidTransport',s("The","directed","movement","of","icosanoids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Icosanoids","are","unsaturated","C20","fatty","acids","and","skeletally","related","compounds","."),4054647). assertion_content_comment('tOboGo_IcosatetraenoicAcidBinding',s("Interacting","selectively","and","non-covalently","with","icosatetraenoic","acid",",","any","straight-chain","fatty","acid","with","twenty","carbon","atoms","and","four","double","bonds","per","molecule","."),4268893). assertion_content_comment('tOboGo_IdenticalProteinBinding',s("Interacting","selectively","and","non-covalently","with","an","identical","protein","or","proteins","."),4253200). assertion_content_comment('tOboGo_IDPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","IDP",",","inosine","5","'","-diphosphate","."),4356056). assertion_content_comment('tOboGo_IDPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","IDP",",","inosine","5","'","-diphosphate","."),4356071). assertion_content_comment('tOboGo_IDPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","IDP",",","inosine","5","'","-diphosphate","."),4227425). assertion_content_comment('tOboGo_IDPPhosphorylation',s("The","process","of","introducing","a","phosphate","group","into","IDP",",","inosine","(","5","'","-",")","diphosphate",",","to","produce","ITP","."),4227428). assertion_content_comment('tOboGo_IgABCellReceptorComplex',s("An","IgA","immunoglobulin","complex","that","is","present","in","the","plasma","membrane","of","B","cells","and","is","composed","of","two","identical","immunoglobulin","heavy","chains","of","an","IgA","isotype","and","two","identical","immunoglobulin","light","chains","and","a","signaling","subunit",",","a","heterodimer","of","the","Ig-alpha","and","Ig-beta","proteins","."),4169782). assertion_content_comment('tOboGo_IgABinding',s("Interacting","selectively","and","non-covalently","with","an","immunoglobulin","of","an","IgA","isotype","."),4233553). assertion_content_comment('tOboGo_IgAImmunoglobulinComplexCirculating',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","an","IgA","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",",","sometimes","complexed","with","J","chain","or","J","chain","and","secretory","component",",","and","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169566). assertion_content_comment('tOboGo_IgAImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgA","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",",","and","sometimes","complexed","with","J","chain","or","J","chain","and","secretory","component",".","An","IgA","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169562). assertion_content_comment('tOboGo_IgAReceptorActivity',s("Combining","with","an","immunoglobulin","of","an","IgA","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4245545). assertion_content_comment('tOboGo_IgDBCellReceptorComplex',s("An","IgD","immunoglobulin","complex","that","is","present","in","the","plasma","membrane","of","B","cells","and","is","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgD","isotype","and","two","identical","immunoglobulin","light","chains","and","a","signaling","subunit",",","a","heterodimer","of","the","Ig-alpha","and","Ig-beta","proteins","."),4169723). assertion_content_comment('tOboGo_IgDBinding',s("Interacting","selectively","and","non-covalently","with","an","immunoglobulin","of","a","D","isotype","."),4325064). assertion_content_comment('tOboGo_IgDImmunoglobulinComplexCirculating',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgD","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",",","and","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169812). assertion_content_comment('tOboGo_IgDImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgD","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","An","IgD","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169721). assertion_content_comment('tOboGo_IgEBCellReceptorComplex',s("An","IgE","immunoglobulin","complex","that","is","present","in","the","plasma","membrane","of","B","cells","and","is","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgE","isotype","and","two","identical","immunoglobulin","light","chains","and","a","signaling","subunit",",","a","heterodimer","of","the","Ig-alpha","and","Ig-beta","proteins","."),4169769). assertion_content_comment('tOboGo_IgEBinding',s("Interacting","selectively","and","non-covalently","with","an","immunoglobulin","of","the","IgE","isotype","."),4233562). assertion_content_comment('tOboGo_IgEImmunoglobulinComplexCirculating',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgE","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",",","and","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169757). assertion_content_comment('tOboGo_IgEImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgE","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","An","IgE","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169746). assertion_content_comment('tOboGo_IgEReceptorActivity',s("Combining","with","an","immunoglobulin","of","the","IgE","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4245522). assertion_content_comment('tOboGo_IgGBCellReceptorComplex',s("An","IgG","immunoglobulin","complex","that","is","present","in","the","plasma","membrane","of","B","cells","and","is","composed","of","two","identical","immunoglobulin","heavy","chains","of","an","IgG","isotype","and","two","identical","immunoglobulin","light","chains","and","a","signaling","subunit",",","a","heterodimer","of","the","Ig-alpha","and","Ig-beta","proteins","."),4169841). assertion_content_comment('tOboGo_IgGBinding',s("Interacting","selectively","and","non-covalently","with","an","immunoglobulin","of","an","IgG","isotype","."),4233571). assertion_content_comment('tOboGo_IgGImmunoglobulinComplexCirculating',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","an","IgG","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",",","and","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169868). assertion_content_comment('tOboGo_IgGImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","an","IgG","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","An","IgG","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169832). assertion_content_comment('tOboGo_IgGImmunoglobulinTranscytosisInEpithelialCellsMediatedByFcRnImmunoglobulinReceptor',s("The","process","of","transporting","IgG","immunoglobulin",",","via","transcytosis","using","the","FcRn","(","also","known","as","the","neonatal","Fc","receptor",";","gene","name","FCGRT",")",",","from","apical","surface","of","an","epithelial","cell","to","the","basolateral","surface","or","vice","versa","depending","on","the","location",".","This","process","is","used","for","uptake","of","IgG","from","the","milk","in","the","gut","in","rodents",",","for","transplacental","transport","of","IgG","from","mother","to","embryo","in","humans",",","and","for","maintenance","of","a","steady-state","distribution","of","IgG","across","epithelial","boundaries","in","general","in","adult","mammals","."),4381480). assertion_content_comment('tOboGo_IgGReceptorActivity',s("Combining","with","an","immunoglobulin","of","an","IgG","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4245321). assertion_content_comment('tOboGo_IgMBCellReceptorComplex',s("An","IgM","immunoglobulin","complex","that","is","present","in","the","plasma","membrane","of","B","cells","and","is","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgM","isotype","and","two","identical","immunoglobulin","light","chains","and","a","signaling","subunit",",","a","heterodimer","of","the","Ig-alpha","and","Ig-beta","proteins","."),4169646). assertion_content_comment('tOboGo_IgMBinding',s("Interacting","selectively","and","non-covalently","with","an","immunoglobulin","of","the","IgM","isotype","."),4375750). assertion_content_comment('tOboGo_IgMImmunoglobulinComplexCirculating',s("A","polymer","of","five","or","six","IgM","core","units","each","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgM","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",";","the","individual","IgM","core","units","are","held","together","via","disulfide","bonds","with","a","single","J","chain","polypeptide","acting","as","a","bridge","between","two","of","the","polymeric","units",".","Circulating","IgM","is","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","in","the","blood","or","lymph","."),4169667). assertion_content_comment('tOboGo_IgMImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgM","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",",","and","in","its","circulating","form","complexed","with","J","chain","in","polymeric","forms",".","An","IgM","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169644). assertion_content_comment('tOboGo_IgMReceptorActivity',s("Combining","with","an","immunoglobulin","of","the","IgM","isotype","via","the","Fc","region","to","initiate","a","change","in","cell","activity","."),4375753). assertion_content_comment('tOboGo_IgWImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgW","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","An","IgW","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169702). assertion_content_comment('tOboGo_IgXImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgX","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","An","IgX","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169681). assertion_content_comment('tOboGo_IgYImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgY","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","An","IgY","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4169500). assertion_content_comment('tOboGo_IgZImmunoglobulinComplex',s("A","protein","complex","composed","of","two","identical","immunoglobulin","heavy","chains","of","the","IgZ","isotype","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds",".","The","IgZ","isotype","is","also","known","as","the","IgT","isotype","in","certain","species","of","fish","."),4169510). assertion_content_comment('tOboGo_IkappaBKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","IkappaB","protein","=","ADP","+","IkappaB","phosphoprotein","."),4255520). assertion_content_comment('tOboGo_IkappaBKinaseComplex',s("A","protein","serine/threonine","kinase","that","phosphorylates","IkappaB",",","thereby","targeting","this","for","proteasomal","degradation","and","allowing","the","nuclear","translocation","of","kB",".","Composed","of","alpha",",","beta","and","gamma","subunits",",","the","latter","not","having","kinase","activity","but","presumed","to","play","a","regulatory","role","."),4255543). assertion_content_comment('tOboGo_ImaginalDiscDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","imaginal","disc","over","time",",","from","its","formation","to","the","metamorphosis","to","form","adult","structures",".","Imaginal","discs","are","epithelial","infoldings","in","the","larvae","of","holometabolous","insects","that","develop","into","adult","structures","(","legs",",","antennae",",","wings",",","etc.",")"),3982523). assertion_content_comment('tOboGo_ImaginalDiscEversion',s("The","eversion","(","turning","inside","out",")","of","imaginal","discs","from","their","peripodial","sacs",",","resulting","in","movement","of","the","epithelium","to","the","outside","of","the","larval","epidermis","."),4015366). assertion_content_comment('tOboGo_ImaginalDiscFusion',s("The","process","following","disc","eversion","whereby","imaginal","discs","fuse","with","adjacent","disc","derivatives","to","form","a","continuous","adult","epidermis","."),4098525). assertion_content_comment('tOboGo_ImaginalDiscFusionThoraxClosure',s("The","joining","of","the","parts","of","the","wing","imaginal","discs",",","giving","rise","to","the","adult","thorax","."),4098535). assertion_content_comment('tOboGo_ImaginalDiscGrowthFactorReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","imaginal","disc","growth","factor","receptor","."),4247122). assertion_content_comment('tOboGo_ImaginalDiscGrowth',s("The","increase","in","mass","of","imaginal","discs","by","cell","proliferation","prior","to","metamorphosis",".","Imaginal","discs","are","epithelial","infoldings","in","the","larvae","of","holometabolous","insects","that","develop","into","adult","structures","(","legs",",","antennae",",","wings",",","etc.",")","during","metamorphosis","from","larval","to","adult","form","."),4017697). assertion_content_comment('tOboGo_ImaginalDiscLineageRestriction',s("Formation","and/or","maintenance","of","a","lineage","boundary","between","compartments","in","an","imaginal","disc","that","cells","cannot","cross",",","thus","separating","the","populations","of","cells","in","each","compartment","."),4017778). assertion_content_comment('tOboGo_ImaginalDiscMorphogenesis',s("The","process","in","which","the","anatomical","structures","derived","from","an","imaginal","disc","are","generated","and","organized",".","The","imaginal","discs","are","epithelial","infoldings","in","the","larvae","of","holometabolous","insects","that","develop","into","adult","appendages","(","legs",",","antennae",",","wings",",","etc.",")","during","metamorphosis","from","larval","to","adult","form","."),3982557). assertion_content_comment('tOboGo_ImaginalDiscPatternFormation',s("The","regionalization","process","that","results","in","defined","areas","of","the","imaginal","disc","that","will","undergo","specific","cell","differentaiton",".","Imaginal","discs","are","epithelial","infoldings","in","the","larvae","of","holometabolous","insects","that","develop","into","adult","appendages","(","legs",",","antennae",",","wings",",","etc.",")","during","metamorphosis","from","larval","to","adult","form","."),4017686). assertion_content_comment('tOboGo_ImidazoloneHydrolaseActivity',s("Catalysis","of","the","reaction",":","N-formiminoglycine","=","imidazolone","+","H2O","."),4327386). assertion_content_comment('tOboGo_ImidazolonepropionaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-","(","4-oxo-4",",","5-dihydro-1H-imidazol-5-yl",")","propanoic","acid","+","H","(","2",")","O","=","N-formimidoyl-L-glutamate","+","H","(","+",")"),4266291). assertion_content_comment('tOboGo_IminodiacetateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","iminodiacetate","+","OH-","=","H","+","+","2","e-","+","glyoxylate","+","glycine","."),4278424). assertion_content_comment('tOboGo_ImmatureBCellDifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","an","immature","B","cell","."),4379653). assertion_content_comment('tOboGo_ImmatureTCellProliferationInThymus',s("The","expansion","of","an","immature","T","cell","population","by","cell","division","in","the","thymus","."),4066029). assertion_content_comment('tOboGo_ImmatureTCellProliferation',s("The","expansion","of","an","immature","T","cell","population","by","cell","division","."),4066026). assertion_content_comment('tOboGo_ImmediateEarlyViralMRNATranscription',s("The","transcriptional","period","of","the","earliest","expressed","viral","genes",",","mainly","encoding","transcriptional","regulators","."),4236737). assertion_content_comment('tOboGo_ImmortalizationOfHostCellByVirus',s("A","virus-induced","cellular","transformation","arising","in","immortalized","cells",",","or","cells","capable","of","indefinite","replication",",","due","to","their","ability","to","produce","their","own","telomerase","."),4236711). assertion_content_comment('tOboGo_ImmortalizationOfHostCell',s("The","modification","of","a","host","cell","into","an","immortal","cell","line","as","a","consequence","of","infection",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080035). assertion_content_comment('tOboGo_ImmuneComplexClearanceByErythrocytes',s("The","process","of","immune","complex","clearance","by","erythrocytes","."),4381491). assertion_content_comment('tOboGo_ImmuneComplexClearanceByMonocytesAndMacrophages',s("The","process","of","immune","complex","clearance","by","monocytes","or","macrophages","."),4151848). assertion_content_comment('tOboGo_ImmuneComplexClearance',s("A","process","directed","at","removing","immune","complexes","from","the","body",".","Immune","complexes","are","clusters","of","antibodies","bound","to","antigen",",","to","which","complement","may","also","be","fixed",",","and","which","may","precipitate","or","remain","in","solution","."),4151846). assertion_content_comment('tOboGo_ImmuneEffectorProcess',s("Any","process","of","the","immune","system","that","can","potentially","contribute","to","an","immune","response","."),3982812). assertion_content_comment('tOboGo_ImmuneResponseInBrainOrNervousSystem',s("An","immune","response","taking","place","in","the","brain","or","nervous","system","."),4379404). assertion_content_comment('tOboGo_ImmuneResponseInPeyerSPatch',s("Immune","response","taking","place","in","the","Peyer","'","s","patch",",","nodular","lymphoid","structures","on","the","serosal","surface","of","the","small","intestine","."),4379384). assertion_content_comment('tOboGo_ImmuneResponseInUrogenitalTract',s("An","immune","response","taking","place","in","the","urogenital","tract",".","The","urogenital","tract","."),4381415). assertion_content_comment('tOboGo_ImmuneResponse',s("Any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat","."),3982899). assertion_content_comment('tOboGo_ImmuneResponseToTumorCell',s("An","immune","system","process","that","functions","in","the","response","of","an","organism","to","a","tumor","cell","."),3999936). assertion_content_comment('tOboGo_ImmuneSystemDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","organismal","system","whose","objective","is","to","provide","calibrated","responses","by","an","organism","to","a","potential","internal","or","invasive","threat",",","over","time",",","from","its","formation","to","the","mature","structure",".","A","system","is","a","regularly","interacting","or","interdependent","group","of","organs","or","tissues","that","work","together","to","carry","out","a","given","biological","process","."),3988978). assertion_content_comment('tOboGo_ImmuneSystemProcess',s("Any","process","involved","in","the","development","or","functioning","of","the","immune","system",",","an","organismal","system","for","calibrated","responses","to","potential","internal","or","invasive","threats","."),3982810). assertion_content_comment('tOboGo_ImmunoglobulinBinding',s("Interacting","selectively","and","non-covalently","with","an","immunoglobulin","."),4233525). assertion_content_comment('tOboGo_ImmunoglobulinBiosyntheticProcessInvolvedInImmuneResponse',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","immunoglobulin","contributing","to","an","immune","response","."),3994322). assertion_content_comment('tOboGo_ImmunoglobulinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","immunoglobulin","."),3994228). assertion_content_comment('tOboGo_ImmunoglobulinComplexCirculating',s("An","immunoglobulin","complex","that","is","secreted","into","extracellular","space","and","found","in","mucosal","areas","or","other","tissues","or","circulating","in","the","blood","or","lymph",".","In","its","canonical","form",",","a","circulating","immunoglobulin","complex","is","composed","of","two","identical","heavy","chains","and","two","identical","light","chains",",","held","together","by","disulfide","bonds",".","Some","forms","of","are","polymers","of","the","basic","structure","and","contain","additional","components","such","as","J-chain","and","the","secretory","component","."),4077561). assertion_content_comment('tOboGo_ImmunoglobulinComplex',s("A","protein","complex","that","in","its","canonical","form","is","composed","of","two","identical","immunoglobulin","heavy","chains","and","two","identical","immunoglobulin","light","chains",",","held","together","by","disulfide","bonds","and","sometimes","complexed","with","additional","proteins",".","An","immunoglobulin","complex","may","be","embedded","in","the","plasma","membrane","or","present","in","the","extracellular","space",",","in","mucosal","areas","or","other","tissues",",","or","circulating","in","the","blood","or","lymph","."),4077557). assertion_content_comment('tOboGo_ImmunoglobulinMediatedImmuneResponse',s("An","immune","response","mediated","by","immunoglobulins",",","whether","cell-bound","or","in","solution","."),3982977). assertion_content_comment('tOboGo_ImmunoglobulinProductionInMucosalTissue',s("The","synthesis","and","release","of","immunoglobulin","in","the","mucosal","tissue","."),3993505). assertion_content_comment('tOboGo_ImmunoglobulinProductionInvolvedInImmunoglobulinMediatedImmuneResponse',s("The","appearance","of","immunoglobulin","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus","during","an","immune","response",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),3993153). assertion_content_comment('tOboGo_ImmunoglobulinProduction',s("The","appearance","of","immunoglobulin","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),3993149). assertion_content_comment('tOboGo_ImmunoglobulinReceptorActivity',s("Combining","with","the","Fc","region","of","an","immunoglobulin","protein","to","initiate","a","change","in","cell","activity","."),4245317). assertion_content_comment('tOboGo_ImmunoglobulinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","one","or","more","specific","sites","on","an","immunoglobulin","receptor","molecule","."),4348489). assertion_content_comment('tOboGo_ImmunoglobulinSecretionInvolvedInImmuneResponse',s("The","regulated","release","of","immunoglobulins","from","a","B","cell","or","plasma","cell","contributing","to","an","immune","response","."),3994346). assertion_content_comment('tOboGo_ImmunoglobulinSecretion',s("The","regulated","release","of","immunoglobulins","from","a","B","cell","or","plasma","cell",",","whose","mechanism","includes","the","use","of","alternate","polyadenylylation","signals","to","favor","the","biosynthesis","of","secreted","forms","of","immunoglobulin","over","membrane-bound","immunoglobulin","."),3994342). assertion_content_comment('tOboGo_ImmunoglobulinTranscytosisInEpithelialCellsMediatedByPolymericImmunoglobulinReceptor',s("The","process","of","transporting","polymeric","IgA","and","polymeric","IgM","immunoglobulin",",","via","transcytosis","mediated","by","the","polymeric","immunoglobulin","receptor","(","pIgR",")",",","from","the","basolateral","surface","to","apical","surface","of","an","epithelial","cell",".","At","the","apical","surface","the","immunoglobulin","binding","portion","of","the","pIgRis","cleaved","and","remains","bound","to","the","transported","immunoglobulin","as","secretory","component","(","SC",")","The","same","process","is","used","for","the","transport","and","excretion","of","IgA","immune","complexes","to","the","luminal","surface","of","the","mucosa","."),3993460). assertion_content_comment('tOboGo_ImmunoglobulinTranscytosisInEpithelialCells',s("The","process","of","transporting","immunoglobulin",",","via","transcytosis",",","from","one","side","of","an","epithelial","cell","to","the","other","."),3993457). assertion_content_comment('tOboGo_ImmunoglobulinVDJRecombination',s("The","process","in","which","immunoglobulin","gene","segments","are","recombined","within","a","single","locus","utilizing","the","conserved","heptamer","and","nonomer","recombination","signal","sequences","(","RSS",")","For","immunoglobulin","heavy","chains","V",",","D",",","and","J","gene","segments","are","joined",",","and","for","immunoglobulin","light","chains","V","and","J","gene","segments","are","joined","."),4170296). assertion_content_comment('tOboGo_ImmunologicalSynapseFormation',s("The","formation","of","an","area","of","close","contact","between","a","lymphocyte","(","T-",",","B-",",","or","natural","killer","cell",")","and","a","target","cell","through","the","clustering","of","particular","signaling","and","adhesion","molecules","and","their","associated","membrane","rafts","on","both","the","lymphocyte","and","target","cell",",","which","facilitates","activation","of","the","lymphocyte",",","transfer","of","membrane","from","the","target","cell","to","the","lymphocyte",",","and","in","some","situations","killing","of","the","target","cell","through","release","of","secretory","granules","and/or","death-pathway","ligand-receptor","interaction","."),3984594). assertion_content_comment('tOboGo_ImmunologicalSynapse',s("An","area","of","close","contact","between","a","lymphocyte","(","T-",",","B-",",","or","natural","killer","cell",")","and","a","target","cell","formed","through","the","clustering","of","particular","signaling","and","adhesion","molecules","and","their","associated","membrane","rafts","on","both","the","lymphocyte","and","the","target","cell","and","facilitating","activation","of","the","lymphocyte",",","transfer","of","membrane","from","the","target","cell","to","the","lymphocyte",",","and","in","some","situations","killing","of","the","target","cell","through","release","of","secretory","granules","and/or","death-pathway","ligand-receptor","interaction","."),4383378). assertion_content_comment('tOboGo_Immunophilin',s("OBSOLETE",".","Any","member","of","a","family","of","receptors","that","includes","the","major","FK506","binding","protein","FKBP","and","cyclophilin",".","These","two","proteins","are","unrelated","in","amino-acid","sequence",",","but","both","possess","peptidyl-prolyl","isomerase","activity","which","is","blocked","by","immunosuppressants","that","block","signal-transduction","pathways","leading","to","T","cell","activation","such","as","FK506","and","rapamycin",",","which","block","FKBP",",","or","cyclosporin","A",",","which","blocks","cyclophilin","."),4306930). assertion_content_comment('tOboGo_IMPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","IMP",",","inosine","monophosphate","."),4226936). assertion_content_comment('tOboGo_IMPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","IMP",",","inosine","monophosphate","."),4226771). assertion_content_comment('tOboGo_IMPCyclohydrolaseActivity',s("Catalysis","of","the","reaction",":","IMP","+","H2O","=","5-formamido-1-","(","5-phosphoribosyl",")","imidazole-4-carboxamide","."),4185993). assertion_content_comment('tOboGo_IMPDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","inosine","5","'","-phosphate","+","NAD","+","+","H2O","=","xanthosine","5","'","-phosphate","+","NADH","+","H","+"),4185871). assertion_content_comment('tOboGo_IMPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","IMP",",","inosine","monophosphate","."),4226683). assertion_content_comment('tOboGo_Importin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220331). assertion_content_comment('tOboGo_IMPSalvage',s("Any","process","which","produces","inosine","monophosphate","from","derivatives","of","it",",","without","de","novo","synthesis","."),4329801). assertion_content_comment('tOboGo_InactivationOfHog1',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4235598). assertion_content_comment('tOboGo_InactivationOfMAPKActivityInvolvedInCellWallBiogenesis',s("Any","process","that","terminates","the","activity","of","the","active","enzyme","MAP","kinase","in","the","context","of","cell","wall","biogenesis",",","the","assembly","and","arrangement","of","the","cell","wall",",","the","rigid","or","semi-rigid","envelope","lying","outside","the","cell","membrane","of","plant",",","fungal","and","most","prokaryotic","cells","."),3973060). assertion_content_comment('tOboGo_InactivationOfMAPKActivityInvolvedInConjugationWithCellularFusion',s("Any","process","that","terminates","the","activity","of","the","active","enzyme","MAP","kinase","in","the","context","of","conjugation","with","cellular","fusion","."),4129604). assertion_content_comment('tOboGo_InactivationOfMAPKActivityInvolvedInInnateImmuneResponse',s("Any","process","that","terminates","the","activity","of","the","active","enzyme","MAP","kinase","in","the","context","of","an","innate","immune","response",",","a","defense","response","mediated","by","germline","encoded","components","that","directly","recognize","components","of","potential","pathogens","."),4083041). assertion_content_comment('tOboGo_InactivationOfMAPKActivityInvolvedInOsmosensorySignalingPathway',s("Any","process","that","terminates","the","activity","of","the","active","enzyme","MAP","kinase","during","osmolarity","sensing","."),3972904). assertion_content_comment('tOboGo_InactivationOfMAPKActivity',s("Any","process","that","terminates","the","activity","of","the","active","enzyme","MAP","kinase","."),3972899). assertion_content_comment('tOboGo_InactivationOfMAPKDuringSporulationSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310032). assertion_content_comment('tOboGo_InactivationOfMAPKDuringSporulationSensuSaccharomyces',s("OBSOLETE",".","Downregulation","of","MAP","kinase","activity","in","the","context","of","sporulation",".","As","in",",","but","not","restricted","to",",","the","taxon","Saccharomyces","(","Saccharomyces",",","ncbi_taxonomy_id",":","4930",")"),4346454). assertion_content_comment('tOboGo_InactivationOfMAPKKActivity',s("Any","process","that","terminates","the","activity","of","the","active","enzyme","MAP","kinase","kinase","."),4118262). assertion_content_comment('tOboGo_InactivationOfMAPKKKActivity',s("Any","process","that","terminates","the","activity","of","the","active","enzyme","MAP","kinase","kinase","kinase","."),4118275). assertion_content_comment('tOboGo_InactivationOfMAPKMatingSensuFungi',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310428). assertion_content_comment('tOboGo_InactivationOfMAPKMatingSensuSaccharomyces',s("OBSOLETE",".","Downregulation","of","MAP","kinase","activity","in","the","context","of","transduction","of","mating","pheromone","signal",",","as","described","for","Saccharomyces","."),4346034). assertion_content_comment('tOboGo_InactivationOfMAPKPseudohyphalGrowth',s("OBSOLETE",".","Downregulation","of","MAP","kinase","activity","in","the","context","of","regulating","pseudohyphal","or","invasive","growth","."),4345956). assertion_content_comment('tOboGo_InactivationOfPaternalXChromosomeByGeneticImprinting',s("Compensating","for","the","two-fold","variation","in","X-chromosome",":","autosome","ratios","between","sexes","by","a","global","inactivation","of","all",",","or","most","of",",","the","genes","on","the","paternal","X-chromosome","in","the","XX","sex","by","genetic","imprinting","."),4156375). assertion_content_comment('tOboGo_InactivationOfPaternalXChromosome',s("Compensating","for","the","two-fold","variation","in","X-chromosome",":","autosome","ratios","between","sexes","by","a","global","inactivation","of","all",",","or","most","of",",","the","genes","specifically","on","the","paternal","X-chromosome","in","the","XX","sex","."),4156372). assertion_content_comment('tOboGo_InactivationOfRecombinationHML',s("The","inactivation","of","recombination","at","sequences","around","a","mating","type","donor","locus",",","with","the","consequence","that","the","other","donor","is","the","only","one","available","for","mating","type","switching",";","exemplified","by","the","HML","locus","and","surrounding","sequences","on","Chromosome","III","in","Saccharomyces","cerevisiae","."),4234446). assertion_content_comment('tOboGo_InactivationOfXChromosomeByDNAMethylation',s("Compensating","for","the","two-fold","variation","in","X-chromosome",":","autosome","ratios","between","sexes","by","a","global","inactivation","of","all",",","or","most","of",",","the","genes","on","one","of","the","X-chromosomes","in","the","XX","sex","by","a","mechanism","of","DNA","methylation","."),4156293). assertion_content_comment('tOboGo_InactivationOfXChromosomeByGeneticImprinting',s("Compensating","for","the","two-fold","variation","in","X-chromosome",":","autosome","ratios","between","sexes","by","a","global","inactivation","of","all",",","or","most","of",",","the","genes","on","one","of","the","X-chromosomes","in","the","XX","sex","by","genetic","imprinting","."),4156356). assertion_content_comment('tOboGo_InactivationOfXChromosomeByHeterochromatinFormation',s("Compensating","for","the","two-fold","variation","in","X-chromosome",":","autosome","ratios","between","sexes","by","a","global","inactivation","of","all",",","or","most","of",",","the","genes","on","one","of","the","X-chromosomes","in","the","XX","sex","by","the","mechanism","of","heterochromatin","formation","."),4156284). assertion_content_comment('tOboGo_InaDSignalingComplex',s("A","complex","of","proteins","that","are","involved","in","phototransduction","and","attached","to","the","transient","receptor","potential","(","TRP",")","channel",".","The","protein","connections","are","mediated","through","inaD","."),4033929). assertion_content_comment('tOboGo_IncipientCellularBudSite',s("The","portion","of","the","budding","yeast","plasma","membrane","where","a","daughter","cell","will","emerge",".","The","yeast","marks","this","spot","with","bud-site","selection","proteins","before","bud","emergence","occurs",".","Actin","is","polarized","to","this","spot","just","prior","to","and","during","bud","emergence","."),4345752). assertion_content_comment('tOboGo_InclusionBodyAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","an","inclusion","body","."),4150296). assertion_content_comment('tOboGo_InclusionBody',s("A","discrete","intracellular","part","formed","of","aggregated","molecules","such","as","proteins","or","other","biopolymers","."),4180241). assertion_content_comment('tOboGo_IndanolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","indan-1-ol","+","NAD","(","P",")","+","=","indanone","+","NAD","(","P",")","H","+","H","+"),4374290). assertion_content_comment('tOboGo_IndeterminateInflorescenceMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","determinate","inflorescences","are","generated","and","organized",".","A","determinate","inflorescence","is","one","that","can","produce","an","undefined","number","of","floral","meristems","."),4384826). assertion_content_comment('tOboGo_IndolalkylamineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","indolalkylamines",",","indole","or","indole","derivatives","containing","a","primary",",","secondary",",","or","tertiary","amine","group","."),4014205). assertion_content_comment('tOboGo_IndolalkylamineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","indolalkylamines",",","indole","or","indole","derivatives","containing","a","primary",",","secondary",",","or","tertiary","amine","group","."),4232112). assertion_content_comment('tOboGo_IndolalkylamineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","indolalkylamines",",","indole","or","indole","derivatives","containing","a","primary",",","secondary",",","or","tertiary","amine","group","."),4014059). assertion_content_comment('tOboGo_IndoleacetaldoximeDehydrataseActivity',s("Catalysis","of","the","reaction",":","(","indol-3-yl",")","acetaldehyde","oxime","=","(","indol-3-yl",")","acetonitrile","+","H","(","2",")","O","."),4374314). assertion_content_comment('tOboGo_IndoleacetamideHydrolaseActivity',s("Catalysis","of","the","reaction",":","indole-3-acetamide","+","H2O","=","indole-3-acetate","+","NH3",".","Indole-3-acetamide","is","known","as","IAM","and","indole-3-acetate","as","IAA","."),4326659). assertion_content_comment('tOboGo_IndoleaceticAcidAmideConjugateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","indole-3-acetic","acid","amide","conjugate",",","a","form","of","indoleacetic","acid","covalently","bound","to","an","amino","acid","or","polypeptide","through","an","amide","bond","."),4339216). assertion_content_comment('tOboGo_IndoleaceticAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","indole-3-acetic","acid",",","a","compound","which","functions","as","a","growth","regulator","in","plants","."),4260967). assertion_content_comment('tOboGo_IndoleaceticAcidBiosyntheticProcessViaTryptophan',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","indole-3-acetic","acid","that","occurs","through","metabolism","of","L-tryptophan","."),4262521). assertion_content_comment('tOboGo_IndoleAceticAcidCarboxylMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","indole","acetic","acid","+","S-adenosyl-methionine","=","methyl","indole","acetic","acid","ester","+","S-adenosyl-homocysteine","."),4279893). assertion_content_comment('tOboGo_IndoleaceticAcidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","indole-3-acetic","acid",",","a","compound","which","functions","as","a","growth","regulator","in","plants","."),4313383). assertion_content_comment('tOboGo_IndoleaceticAcidConjugateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","indole-3-acetic","acid","conjugate",",","a","form","of","indoleacetic","acid","covalently","bound","to","another","molecule","."),4339200). assertion_content_comment('tOboGo_IndoleaceticAcidConjugateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","indole-3-acetic","acid","conjugate",",","a","form","of","indoleacetic","acid","covalently","bound","to","another","molecule","."),4339185). assertion_content_comment('tOboGo_IndoleaceticAcidEsterConjugateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","indole-3-acetic","acid","amide","conjugate",",","a","form","of","indoleacetic","acid","covalently","bound","to","an","a","sugar","or","polyol","through","an","ester","bond","."),4339232). assertion_content_comment('tOboGo_IndoleaceticAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","indole-3-acetic","acid",",","a","compound","which","functions","as","a","growth","regulator","in","plants","."),4241839). assertion_content_comment('tOboGo_IndoleBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","indole","(","2",",","3-benzopyrrole",")",",","the","basis","of","many","biologically","active","substances","(","e.g",".","serotonin",",","tryptophan",")"),4312474). assertion_content_comment('tOboGo_IndolebutyricAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","indolebutyric","acid",",","a","compound","that","serves","as","an","active","or","storage","form","of","the","hormone","indole-3-acetic","acid","(","an","auxin",")","in","many","plants","."),4182276). assertion_content_comment('tOboGo_IndoleCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","indole","(","2",",","3-benzopyrrole",")",",","the","basis","of","many","biologically","active","substances","(","e.g",".","serotonin",",","tryptophan",")"),4312489). assertion_content_comment('tOboGo_IndoleGlucosinolateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","indole","glucosinolates",",","sulfur-containing","compounds","that","have","a","common","structure","linked","to","an","R","group","derived","from","tryptophan","."),4262684). assertion_content_comment('tOboGo_IndoleGlucosinolateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","indole","glucosinolates",",","sulfur-containing","compounds","that","have","a","common","structure","linked","to","an","R","group","derived","from","tryptophan","."),4313108). assertion_content_comment('tOboGo_IndoleGlucosinolateMetabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","indole","glucosinolates",".","Glucosinolates","are","sulfur-containing","compounds","that","have","a","common","structure","linked","to","an","R","group","derived","from","tryptophan",";","indoles","are","biologically","active","substances","based","on","2",",","3-benzopyrrole",",","formed","during","the","catabolism","of","tryptophan","."),4262680). assertion_content_comment('tOboGo_IndolelactateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","3-","(","indol-3-yl",")","lactate","+","NAD","(","+",")","=","3-","(","indol-3-yl",")","pyruvate","+","H","(","+",")","+","NADH","."),4374329). assertion_content_comment('tOboGo_IndoleMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","indole","(","2",",","3-benzopyrrole",")",",","the","basis","of","many","biologically","active","substances","(","e.g",".","serotonin",",","tryptophan",")"),4312462). assertion_content_comment('tOboGo_IndolePhytoalexinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","indole","phytoalexins",",","any","indole","compound","produced","by","plants","as","part","of","their","defense","response","."),4260706). assertion_content_comment('tOboGo_IndolePhytoalexinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","indole","phytoalexins",",","any","indole","compound","produced","by","plants","as","part","of","their","defense","response","."),4354278). assertion_content_comment('tOboGo_IndolePhytoalexinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","indole","phytoalexins",",","any","indole","compound","produced","by","plants","as","part","of","their","defense","response","."),4197028). assertion_content_comment('tOboGo_IndolepyruvateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","indolepyruvate","=","CO2","+","indole","acetaldehyde","."),4370305). assertion_content_comment('tOboGo_IndolepyruvateFerredoxinOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","(","indol-3-yl",")","pyruvate","+","CoA","+","oxidized","ferredoxin","=","S-2-","(","indol-3-yl",")","acetyl-CoA","+","CO2","+","reduced","ferredoxin","."),4327396). assertion_content_comment('tOboGo_IndolylacetylinositolArabinosyltransferaseActivity',s("Catalysis","of","the","reaction",":","1L-1-O-","(","indol-3-yl",")","acetyl-myo-inositol","+","UDP-L-arabinose","=","(","indol-3-yl",")","acetyl-myo-inositol","3-L-arabinoside","+","H","(","+",")","+","UDP","."),4267350). assertion_content_comment('tOboGo_InducedSystemicResistanceEthyleneMediatedSignalingPathway',s("The","series","of","molecular","signals","mediated","by","ethylene","(","ethene",")","involved","in","induced","systemic","resistance","."),4021933). assertion_content_comment('tOboGo_InducedSystemicResistanceJasmonicAcidMediatedSignalingPathway',s("The","series","of","molecular","signals","mediated","by","jasmonic","acid","involved","in","induced","systemic","resistance","."),4022017). assertion_content_comment('tOboGo_InducedSystemicResistance',s("A","response","to","non-pathogenic","bacteria","that","confers","broad","spectrum","systemic","resistance","to","disease","that","does","not","depend","upon","salicylic","acid","signaling","."),4021863). assertion_content_comment('tOboGo_InductionByHostOfSymbiontDefenseResponse',s("The","activation","by","an","organism","of","the","defense","response","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190776). assertion_content_comment('tOboGo_InductionByOrganismOfApoptosisInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates","programmed","cell","death","by","apoptosis","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190848). assertion_content_comment('tOboGo_InductionByOrganismOfDefenseResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("The","activation","by","an","organism","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190601). assertion_content_comment('tOboGo_InductionByOrganismOfImmuneResponseOfOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates","the","immune","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction",".","The","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat","."),4186952). assertion_content_comment('tOboGo_InductionByOrganismOfInducedSystemicResistanceInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates","induced","systemic","resistance",",","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196354). assertion_content_comment('tOboGo_InductionByOrganismOfInducedSystemicResistanceInSymbiont',s("OBSOLETE",".","Any","process","in","which","an","organism","activates","induced","systemic","resistance","in","the","symbiont",";","induced","systemic","resistance","is","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197083). assertion_content_comment('tOboGo_InductionByOrganismOfInnateImmunityInOtherOrganismInvolvedInSymbioticInteraction',s("The","activation","by","an","organism","of","the","innate","immune","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190607). assertion_content_comment('tOboGo_InductionByOrganismOfPhytoalexinProductionInOtherOrganismInvolvedInSymbioticInteraction',s("The","activation","by","an","organism","of","the","production","of","phytoalexins","that","occurs","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195780). assertion_content_comment('tOboGo_InductionByOrganismOfProgrammedCellDeathInOtherOrganismInvolvedInSymbioticInteraction',s("The","activation","by","an","organism","of","programmed","cell","death","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4188091). assertion_content_comment('tOboGo_InductionByOrganismOfSymbiontApoptosis',s("OBSOLETE",".","Any","process","by","which","an","organism","activates","programmed","cell","death","in","the","symbiont",",","where","programmed","cell","death","proceeds","by","apoptosis",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190834). assertion_content_comment('tOboGo_InductionByOrganismOfSymbiontImmuneResponse',s("OBSOLETE",".","Any","process","by","which","an","organism","activates","the","immune","response","of","the","symbiont","organism",";","the","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186942). assertion_content_comment('tOboGo_InductionByOrganismOfSymbiontInnateImmunity',s("OBSOLETE",".","The","activation","by","an","organism","of","the","innate","immune","response","of","the","symbiont","organism",";","the","innate","immune","response","is","the","symbiont","'","s","first","line","of","defense","against","infection",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190876). assertion_content_comment('tOboGo_InductionByOrganismOfSymbiontPhytoalexinProduction',s("OBSOLETE",".","The","activation","by","an","organism","of","the","production","of","phytoalexins","as","part","of","the","defense","response","of","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190669). assertion_content_comment('tOboGo_InductionByOrganismOfSymbiontProgrammedCellDeath',s("OBSOLETE",".","The","activation","by","an","organism","of","programmed","cell","death","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190680). assertion_content_comment('tOboGo_InductionByOrganismOfSystemicAcquiredResistanceInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","in","which","an","organism","activates","systemic","acquired","resistance",",","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",",","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196323). assertion_content_comment('tOboGo_InductionByOrganismOfSystemicAcquiredResistanceInSymbiont',s("OBSOLETE",".","Any","process","in","which","an","organism","activates","systemic","acquired","resistance","in","the","symbiont","organism",";","systemic","acquired","resistance","is","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4197096). assertion_content_comment('tOboGo_InductionBySymbiontInHostOfTumorNoduleOrGrowthContainingTransformedCells',s("The","process","in","which","an","organism","causes","the","formation","in","its","host","organism","of","an","abnormal","growth","whose","cells","have","been","transformed","and","continue","to","exist","in","the","absence","of","the","first","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4289217). assertion_content_comment('tOboGo_InductionBySymbiontInHostOfTumorNoduleOrGrowth',s("The","process","in","which","an","organism","causes","the","formation","of","an","abnormal","mass","of","cells","in","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4289207). assertion_content_comment('tOboGo_InductionBySymbiontOfHostApoptosis',s("Any","process","in","which","an","organism","activates","programmed","cell","death","in","the","host",",","where","programmed","cell","death","proceeds","by","apoptosis",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195242). assertion_content_comment('tOboGo_InductionBySymbiontOfHostDefenseResponse',s("The","activation","by","an","organism","of","the","defense","response","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190636). assertion_content_comment('tOboGo_InductionBySymbiontOfHostImmuneResponse',s("Any","process","in","which","an","organism","activates","the","immune","response","of","the","host","organism",";","the","immune","response","is","any","immune","system","process","that","functions","in","the","calibrated","response","of","an","organism","to","a","potential","internal","or","invasive","threat",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4186965). assertion_content_comment('tOboGo_InductionBySymbiontOfHostInducedSystemicResistance',s("Any","process","in","which","an","organism","activates","induced","systemic","resistance","in","the","host",";","induced","systemic","resistance","is","a","response","that","confers","broad","spectrum","systemic","resistance","to","disease","and","that","does","not","depend","upon","salicylic","acid","signaling",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4196362). assertion_content_comment('tOboGo_InductionBySymbiontOfHostInnateImmunity',s("The","activation","by","an","organism","of","the","innate","immune","response","of","the","host","organism",";","the","innate","immune","response","is","the","host","'","s","first","line","of","defense","against","infection",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4190614). assertion_content_comment('tOboGo_InductionBySymbiontOfHostPhytoalexinProduction',s("The","activation","by","an","organism","of","the","production","of","phytoalexins","as","part","of","the","defense","response","of","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195815). assertion_content_comment('tOboGo_InductionBySymbiontOfHostProgrammedCellDeath',s("The","activation","by","an","organism","of","programmed","cell","death","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195201). assertion_content_comment('tOboGo_InductionBySymbiontOfHostSystemicAcquiredResistance',s("Any","process","in","which","an","organism","activates","systemic","acquired","resistance","in","the","host","organism",";","systemic","acquired","resistance","is","a","salicylic","acid-mediated","response","that","confers","broad","spectrum","systemic","resistance",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4196331). assertion_content_comment('tOboGo_InductionByVirusOfHostApoptosis',s("The","set","of","viral","processes","that","result","in","the","induction","of","apoptosis","of","infected","cells",",","facilitating","release","and","spread","of","progeny","virions","."),4236815). assertion_content_comment('tOboGo_InductionByVirusOfModificationOfHostRNAPolymeraseII',s("The","viral","induction","of","modification","to","the","host","RNA","polymerase","II","."),4354891). assertion_content_comment('tOboGo_InductionInSymbiontOfTumorNoduleOrGrowthContainingTransformedCells',s("OBSOLETE",".","The","process","by","which","an","organism","causes","the","formation","in","its","symbiont","organism","of","an","abnormal","growth","whose","cells","have","been","transformed","and","continue","to","exist","in","the","absence","of","the","first","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282487). assertion_content_comment('tOboGo_InductionInSymbiontOfTumorNoduleOrGrowth',s("OBSOLETE",".","The","process","by","which","an","associated","organism","causes","the","formation","of","an","abnormal","mass","of","cells","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4282465). assertion_content_comment('tOboGo_InductionOfApoptosisByExtracellularSignals',s("Any","process","induced","by","extracellular","signals","that","directly","activates","any","of","the","steps","required","for","cell","death","by","apoptosis","."),4145613). assertion_content_comment('tOboGo_InductionOfApoptosisByGranzyme',s("Any","process","induced","by","granzyme","that","directly","activates","any","of","the","steps","required","for","cell","death","by","apoptosis",".","Granzymes","are","serine","proteases","that","are","secreted","by","cytotoxic","T","cells","and","natural","killer","cells","to","induce","apoptosis","in","target","cells","."),4253419). assertion_content_comment('tOboGo_InductionOfApoptosisByHormones',s("Any","process","induced","by","hormones","that","directly","activates","any","of","the","steps","required","for","cell","death","by","apoptosis","."),4253401). assertion_content_comment('tOboGo_InductionOfApoptosisByIntracellularSignals',s("Any","process","induced","by","intracellular","signals","that","directly","activates","any","of","the","steps","required","for","cell","death","by","apoptosis","."),4158217). assertion_content_comment('tOboGo_InductionOfApoptosisByIonicChanges',s("Any","process","induced","by","changes","in","intracellular","ion","homeostasis","that","directly","activates","any","of","the","steps","required","for","cell","death","by","apoptosis","."),4253410). assertion_content_comment('tOboGo_InductionOfApoptosisByOxidativeStress',s("The","activation",",","by","oxidative","stress",",","of","any","of","the","steps","required","for","cell","death","by","apoptosis","."),4253317). assertion_content_comment('tOboGo_InductionOfApoptosisByP53',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4232410). assertion_content_comment('tOboGo_InductionOfApoptosisInResponseToChemicalStimulus',s("Any","process","that","directly","activates","any","of","the","steps","required","for","cell","death","by","apoptosis","as","a","result","of","a","chemical","stimulus","."),4145627). assertion_content_comment('tOboGo_InductionOfApoptosis',s("A","process","that","directly","activates","any","of","the","steps","required","for","cell","death","by","apoptosis","."),3983110). assertion_content_comment('tOboGo_InductionOfApoptosisViaDeathDomainReceptors',s("Any","process","that","directly","activates","any","of","the","steps","required","for","cell","death","by","apoptosis","as","a","result","of","a","death","receptor","binding","to","one","of","its","physiological","ligands","."),4253428). assertion_content_comment('tOboGo_InductionOfAutolysinActivityInOtherOrganism',s("Any","process","in","which","an","organism","initiates","the","activity","of","the","inactive","enzyme","autolysin","in","another","organism",".","The","autolysin","enzyme","belongs","to",",","and","is","active","in",",","the","other","organism","."),4285453). assertion_content_comment('tOboGo_InductionOfBacterialAgglutination',s("Any","process","in","which","infecting","bacteria","are","clumped","together","by","a","host","organism","."),4317574). assertion_content_comment('tOboGo_InductionOfCompoundEyeRetinalCellProgrammedCellDeath',s("A","process","that","directly","activates","any","of","the","steps","required","for","programmed","cell","death","in","the","compound","eye","retina","."),4359934). assertion_content_comment('tOboGo_InductionOfConjugationUponCarbonStarvation',s("The","process","in","which","a","cell","initiates","conjugation","with","cellular","fusion","upon","carbon","starvation","."),4318805). assertion_content_comment('tOboGo_InductionOfConjugationUponNitrogenStarvation',s("The","process","in","which","a","cell","initiates","conjugation","with","cellular","fusion","upon","nitrogen","starvation","."),4114204). assertion_content_comment('tOboGo_InductionOfConjugationUponNutrientStarvation',s("The","process","in","which","a","cell","initiates","conjugation","with","cellular","fusion","upon","starvation","for","one","or","more","nutrients","."),4114202). assertion_content_comment('tOboGo_InductionOfConjugationWithCellularFusion',s("The","process","in","which","a","cell","initiates","conjugation","with","cellular","fusion",".","Conjugation","with","cellular","fusion","is","the","process","that","results","in","the","union","of","cellular","and","genetic","information","from","compatible","mating","types","."),4029925). assertion_content_comment('tOboGo_InductionOfHostImmuneResponseByVirus',s("The","induction","by","a","virus","of","an","immune","response","in","the","host","organism","."),4356556). assertion_content_comment('tOboGo_InductionOfNecroptosisByExtracellularSignals',s("Any","process","that","starts","the","inactive","process","of","necroptosis","as","a","result","of","a","signal","outside","the","cell",".","Necroptosis","is","a","necrotic","cell","death","process","that","results","from","the","activation","of","endogenous","cellular","processes",",","such","as","signaling","involving","death","domain","receptors","and","Toll-like","receptors","."),4160712). assertion_content_comment('tOboGo_InductionOfNecroptosis',s("Any","process","that","starts","the","inactive","process","of","necroptosis",".","Necroptosis","is","a","necrotic","cell","death","process","that","results","from","the","activation","of","endogenous","cellular","processes",",","such","as","signaling","involving","death","domain","receptors","and","Toll-like","receptors","."),4160693). assertion_content_comment('tOboGo_InductionOfNegativeChemotaxis',s("Any","process","that","initiates","the","directed","movement","of","a","motile","cell","or","organism","towards","a","lower","concentration","in","a","concentration","gradient","of","a","specific","chemical","."),4273112). assertion_content_comment('tOboGo_InductionOfPhytoalexinBiosyntheticProcess',s("The","activation","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","phytoalexins",",","low-molecular","mass",",","lipophilic","antimicrobial","compounds","that","accumulate","rapidly","at","sites","of","incompatible","pathogen","infection","."),4260988). assertion_content_comment('tOboGo_InductionOfPositiveChemotaxis',s("Any","process","that","initiates","the","directed","movement","of","a","motile","cell","or","organism","towards","a","higher","concentration","in","a","concentration","gradient","of","a","specific","chemical","."),4273212). assertion_content_comment('tOboGo_InductionOfProgrammedCellDeathByEcdysone',s("Any","process","induced","by","the","steroid","hormone","20-hydroxyecdysone","(","ecdysone",")","that","directly","activates","any","of","the","steps","required","for","programmed","cell","death","."),4073021). assertion_content_comment('tOboGo_InductionOfProgrammedCellDeathByHormones',s("Any","process","induced","by","hormones","that","directly","activates","any","of","the","steps","required","for","programmed","cell","death","."),4073019). assertion_content_comment('tOboGo_InductionOfProgrammedCellDeathInResponseToChemicalStimulus',s("A","process","which","directly","activates","any","of","the","steps","required","for","programmed","cell","death","as","a","result","of","a","chemical","stimulus","."),4145624). assertion_content_comment('tOboGo_InductionOfProgrammedCellDeath',s("A","process","which","directly","activates","any","of","the","steps","required","for","programmed","cell","death","."),3983078). assertion_content_comment('tOboGo_InductionOfRetinalProgrammedCellDeath',s("A","process","which","directly","activates","any","of","the","steps","required","for","programmed","cell","death","in","the","retina","."),4359932). assertion_content_comment('tOboGo_InductionOfSynapticPlasticityByChemicalSubstance',s("The","process","in","which","a","chemical","substance","activates","synaptic","plasticity",",","the","ability","of","synapses","to","change","as","circumstances","require","."),4183162). assertion_content_comment('tOboGo_InductionOfTumorNoduleOrGrowthContainingTransformedCellsInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","causes","the","formation","in","a","second","organism","of","an","abnormal","growth","whose","cells","have","been","transformed","and","continue","to","exist","in","the","absence","of","the","first","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4282598). assertion_content_comment('tOboGo_InductionOfTumorNoduleOrGrowthInOtherOrganismInvolvedInSymbioticInteraction',s("The","process","in","which","an","organism","causes","the","formation","of","an","abnormal","mass","of","cells","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4281381). assertion_content_comment('tOboGo_InductiveCellMigration',s("Migration","of","a","cell","in","a","multicellular","organism","that",",","having","changed","its","location",",","is","required","to","induce","normal","properties","in","one","or","more","cells","at","its","new","location",".","An","example","of","this","would","be","the","distal","tip","cells","of","Caenorhabditis","elegans","."),4232606). assertion_content_comment('tOboGo_InductiveMesenchymalToEpithelialCellSignaling',s("Signaling","at","short","range","from","mesenchymal","cells","to","cells","of","an","epithelium","that","results","in","a","developmental","change","in","the","epithelial","cells","."),4116817). assertion_content_comment('tOboGo_InfectedHostCellSurfaceKnob',s("Protrusion","that","develops","in","the","plasma","membrane","of","a","parasitized","erythrocyte",".","An","example","of","this","component","is","found","in","Plasmodium","species","."),4079985). assertion_content_comment('tOboGo_InfectionCushionFormationOnOrNearHost',s("The","process","in","which","an","organized","mass","of","hyphae","is","formed","on","or","near","the","host","organism",",","and","numerous","infective","hyphae","develop","from","the","hyphae","mass",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4146565). assertion_content_comment('tOboGo_InferiorColliculusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","inferior","colliculus","over","time",",","from","its","formation","to","the","mature","structure",".","The","inferior","colliculus","(","IC",")","(","Latin",",","lower","hill",")","is","the","principal","midbrain","nucleus","of","the","auditory","pathway","and","receives","input","from","several","more","peripheral","brainstem","nuclei","in","the","auditory","pathway",",","as","well","as","inputs","from","the","auditory","cortex",".","The","inferior","colliculus","has","three","subdivisions",":","the","central","nucleus","(","CIC",")",",","a","dorsal","cortex","(","DCIC",")","by","which","it","is","surrounded",",","and","an","external","cortex","(","ICX",")","which","is","located","laterally","."),4133511). assertion_content_comment('tOboGo_InferiorOlivaryNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","inferior","olivary","nucleus","over","time",",","from","its","formation","to","the","mature","structure",".","The","inferior","olivary","nucleus","is","a","capsule-shaped","structure","in","the","ventral","medulla","located","just","lateral","and","dorsal","to","the","medullary","pyramids",".","Neurons","in","the","inferior","olivary","nucleus","are","the","source","of","climbing","fiber","input","to","the","cerebellar","cortex",";","these","neurons","have","been","implicated","in","various","functions",",","such","as","learning","and","timing","of","movements","."),4043195). 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assertion_content_comment('tOboGo_InferiorOlivaryNucleusMaturation',s("A","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","the","inferior","olivary","nucleus","to","attain","its","fully","functional","state",".","The","inferior","olivary","nucleus","is","a","capsule-shaped","structure","in","the","ventral","medulla","located","just","lateral","and","dorsal","to","the","medullary","pyramids",".","Neurons","in","the","inferior","olivary","nucleus","are","the","source","of","climbing","fiber","input","to","the","cerebellar","cortex",";","these","neurons","have","been","implicated","in","various","functions",",","such","as","learning","and","timing","of","movements","."),4043263). 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assertion_content_comment('tOboGo_InferiorOlivaryNucleusStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","inferior","olivary","nucleus","structure",".","The","inferior","olivary","nucleus","is","a","capsule-shaped","structure","in","the","ventral","medulla","located","just","lateral","and","dorsal","to","the","medullary","pyramids",".","Neurons","in","the","inferior","olivary","nucleus","are","the","source","of","climbing","fiber","input","to","the","cerebellar","cortex",";","these","neurons","have","been","implicated","in","various","functions",",","such","as","learning","and","timing","of","movements","."),4043236). assertion_content_comment('tOboGo_InferiorRapheNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","inferior","raphe","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042628). assertion_content_comment('tOboGo_InferiorReticularFormationDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","inferior","reticular","formation","over","time",",","from","its","formation","to","the","mature","structure","."),4042699). assertion_content_comment('tOboGo_InferiorSalivaryNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","inferior","salivary","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4049438). assertion_content_comment('tOboGo_InflammatoryCellApoptosis',s("The","process","of","apoptosis","in","inflammatory","cells",",","any","cell","participating","in","the","inflammatory","response","to","a","foreign","substance","e.g",".","neutrophil",",","macrophage","."),4232394). assertion_content_comment('tOboGo_InflammatoryResponse',s("The","immediate","defensive","reaction","(","by","vertebrate","tissue",")","to","infection","or","injury","caused","by","chemical","or","physical","agents",".","The","process","is","characterized","by","local","vasodilation",",","extravasation","of","plasma","into","intercellular","spaces","and","accumulation","of","white","blood","cells","and","macrophages","."),3982887). assertion_content_comment('tOboGo_InflammatoryResponseToAntigenicStimulus',s("An","inflammatory","response","to","an","antigenic","stimulus",",","which","can","be","include","any","number","of","T","cell","or","B","cell","epitopes","."),3982901). assertion_content_comment('tOboGo_InflorescenceDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","inflorescence","over","time",",","from","its","formation","to","the","mature","structure","."),4029411). assertion_content_comment('tOboGo_InflorescenceMeristemGrowth',s("The","increase","in","size","or","mass","of","an","inflorescence","meristem",",","a","population","of","undifferentiated","cells","in","a","plant","shoot","which","produces","small","leaves","and","then","floral","meristems",",","which","will","give","rise","to","flowers","."),4029432). assertion_content_comment('tOboGo_InflorescenceMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","inflorescences","are","generated","and","organized",".","An","inflorescence","is","the","part","of","a","seed","plant","body","that","is","usually","above","ground","and","that","can","bear","flowers","."),4103727). assertion_content_comment('tOboGo_IngressionInvolvedInGastrulationWithMouthFormingSecond',s("The","migration","of","individual","cells","into","the","embryo","involved","in","deuterostomic","gastrulation","."),4109511). assertion_content_comment('tOboGo_InheritanceOfOxidativelyModifiedProteinsInvolvedInReplicativeCellAging',s("A","protein","localization","process","in","which","progeny","cells","acquire",",","or","are","barred","from","acquiring",",","proteins","that","have","been","altered","by","reaction","with","reactive","oxygen","species","in","dividing","aging","cells","."),3980150). assertion_content_comment('tOboGo_InhibinAComplex',s("Heterodimeric","hormone","composed","of","an","inhibin","alpha","subunit","complexed","with","an","inhibin","beta-A","subunit","."),4324672). assertion_content_comment('tOboGo_InhibinAlphaBinding',s("Interacting","selectively","and","non-covalently","with","inhibin","alpha","."),4349111). assertion_content_comment('tOboGo_InhibinBComplex',s("Heterodimeric","hormone","composed","of","an","inhibin","alpha","subunit","complexed","with","an","inhibin","beta-B","subunit","."),4324662). assertion_content_comment('tOboGo_InhibinBinding',s("Interacting","selectively","and","non-covalently","with","an","inhibin","monomer",",","any","of","the","polypeptides","that","combine","to","form","activin","and","inhibin","dimers","."),4349108). assertion_content_comment('tOboGo_InhibinComplexBinding',s("Interacting","selectively","and","non-covalently","with","an","inhibin","complex",",","a","dimer","of","one","inhibin-alpha","subunit","and","one","inhibin-beta","subunit","."),4349315). assertion_content_comment('tOboGo_InhibinComplex',s("Heterodimeric","hormone","composed","of","an","inhibin","alpha","subunit","complexed","with","either","an","inhibin","beta-A","subunit",",","to","form","inhibin","A",",","or","an","inhibin","beta-B","subunit",",","to","form","inhibin","B","."),4094616). assertion_content_comment('tOboGo_InhibinSecretion',s("The","regulated","release","of","an","inhibin",",","either","of","two","glycoproteins","(","designated","A","and","B",")",",","secreted","by","the","gonads","and","present","in","seminal","plasma","and","follicular","fluid",",","that","inhibit","pituitary","production","of","follicle-stimulating","hormone","."),4056124). assertion_content_comment('tOboGo_Inhibin',s("OBSOLETE",".","Either","of","two","glycoproteins","(","designated","A","and","B",")",",","secreted","by","the","gonads","and","present","in","seminal","plasma","and","follicular","fluid",",","that","inhibit","pituitary","production","of","follicle-stimulating","hormone","."),4302011). assertion_content_comment('tOboGo_InhibitionOfAcetylcholineUptake',s("Any","process","that","prevents","the","activation","of","the","directed","movement","of","acetylcholine","into","a","cell","."),4285236). assertion_content_comment('tOboGo_InhibitionOfAdenylateCyclaseActivityByAdrenergicReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","adrenergic","receptor","binding","to","its","physiological","ligand",",","followed","by","inhibition","of","adenylyl","cyclase","and","a","subsequent","decrease","in","the","concentration","of","cyclic","AMP","."),4170768). assertion_content_comment('tOboGo_InhibitionOfAdenylateCyclaseActivityByDopamineReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","dopamine","receptor","binding","to","its","physiological","ligand",",","followed","by","inhibition","of","adenylyl","cyclase","and","a","subsequent","decrease","in","the","concentration","of","cyclic","AMP","."),4235917). assertion_content_comment('tOboGo_InhibitionOfAdenylateCyclaseActivityByMetabotropicGlutamateReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","metabotropic","glutamate","receptor","binding","to","its","physiological","ligand",",","followed","by","inhibition","of","adenylyl","cyclase","and","a","subsequent","decrease","in","the","concentration","of","cyclic","AMP","."),4235982). assertion_content_comment('tOboGo_InhibitionOfAdenylateCyclaseActivityByMuscarinicAcetylcholineReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","muscarinic","acetylcholine","receptor","binding","to","its","physiological","ligand",",","followed","by","inhibition","of","adenylyl","cyclase","and","a","subsequent","decrease","in","the","concentration","of","cyclic","AMP","."),4235995). assertion_content_comment('tOboGo_InhibitionOfAdenylateCyclaseActivityByOpioidReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","an","opioid","receptor","binding","to","its","physiological","ligand",",","followed","by","inhibition","of","adenylyl","cyclase","and","a","subsequent","decrease","in","the","concentration","of","cyclic","AMP","."),4322367). assertion_content_comment('tOboGo_InhibitionOfAdenylateCyclaseActivityBySerotoninReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","serotonin","receptor","binding","to","its","physiological","ligand",",","followed","by","inhibition","of","adenylyl","cyclase","and","a","subsequent","decrease","in","the","concentration","of","cyclic","AMP","."),4235956). assertion_content_comment('tOboGo_InhibitionOfDopamineUptake',s("Any","process","that","prevents","the","activation","of","the","directed","movement","of","dopamine","into","a","cell","."),4284126). assertion_content_comment('tOboGo_InhibitionOfEpinephrineUptake',s("Any","process","that","prevents","the","activation","of","the","directed","movement","of","epinephrine","into","a","cell","."),4285128). assertion_content_comment('tOboGo_InhibitionOfHistamineUptake',s("Any","process","that","prevents","the","activation","of","the","directed","movement","of","histamine","into","a","cell","."),4284590). assertion_content_comment('tOboGo_InhibitionOfNeuroepithelialCellDifferentiation',s("Any","process","that","prevents","the","activation","of","neuroepithelial","cell","differentiation",".","Neuroepithelial","cell","differentiation","is","the","process","in","which","epiblast","cells","acquire","specialized","features","of","neuroepithelial","cells","."),3989755). assertion_content_comment('tOboGo_InhibitionOfNeurotransmitterUptake',s("Any","process","that","prevents","the","activation","of","the","directed","movement","of","a","neurotransmitter","into","a","cell","."),4284123). assertion_content_comment('tOboGo_InhibitionOfNorepinephrineUptake',s("Any","process","that","prevents","the","activation","of","the","directed","movement","of","norepinephrine","into","a","cell","."),4285140). assertion_content_comment('tOboGo_InhibitionOfSerotoninUptake',s("Any","process","that","prevents","the","activation","of","the","directed","movement","of","serotonin","into","a","cell","."),4284576). assertion_content_comment('tOboGo_InhibitorOfTheEstablishmentOfCompetenceForTransformationActivity',s("OBSOLETE",".","Inhibits","the","establishment","of","competence","for","transformation","."),4298551). assertion_content_comment('tOboGo_InhibitoryMHCClassIReceptorActivity',s("Combining","with","a","MHC","class","I","protein","complex","to","mediate","signaling","that","inhibits","activation","of","a","lymphocyte","."),4310931). assertion_content_comment('tOboGo_InhibitorySMADProtein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4215379). assertion_content_comment('tOboGo_InhibitorySynapse',s("A","synapse","in","which","an","action","potential","in","the","presynaptic","cell","reduces","the","probability","of","an","action","potential","occurring","in","the","postsynaptic","cell","."),4159352). assertion_content_comment('tOboGo_InitialSegment',s("Portion","of","the","axon","proximal","to","the","neuronal","cell","body",",","at","the","level","of","the","axon","hillock",".","The","action","potentials","that","propagate","along","the","axon","are","generated","at","the","level","of","this","initial","segment","."),4093148). assertion_content_comment('tOboGo_InitiationOfAcetateCatabolicProcessByAcetate',s("The","activation",",","by","acetate",",","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate","."),4086633). assertion_content_comment('tOboGo_InitiationOfAcetateCatabolicProcess',s("The","activation","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","acetate","."),4086628). assertion_content_comment('tOboGo_InitiationOfAdrenergicReceptorSignalTransduction',s("A","process","of","signal","initiation","in","which","epinephrine","or","norepinephrine","causes","activation","of","an","adrenergic","receptor","."),4125492). assertion_content_comment('tOboGo_InitiationOfAppressoriumOnOrNearHost',s("The","process","in","which","a","relatively","unspecialized","cell","starts","to","acquire","specialized","features","of","the","symbiont","appressorium","to","aid","in","infection","of","the","host",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147377). assertion_content_comment('tOboGo_InitiationOfDorsalClosure',s("Events","that","occur","at","the","start","of","dorsal","closure","."),4019726). assertion_content_comment('tOboGo_InitiationOfMovementInvolvedInCerebralCortexRadialGliaGuidedMigration',s("The","initial","stages","of","cell","motility","involved","in","the","glial-mediated","movement","of","cells","in","the","developing","cerebral","cortex","."),4049948). assertion_content_comment('tOboGo_InitiationOfNeuralTubeClosure',s("The","process","in","which","closure","points","are","established","at","multiple","points","and","along","the","neural","rostrocaudal","axis","."),4046447). assertion_content_comment('tOboGo_InitiationOfPrimordialOvarianFollicleGrowth',s("Increase","in","size","of","primordial","follicles","including","proliferation","and","shape","changes","of","granulosa","and/or","theca","cells","until","oocyte","is","surrounded","by","one","layer","of","cuboidal","shaped","granulosa","cells","(","primary","follicle",")"),3981836). assertion_content_comment('tOboGo_InitiationOfRoundaboutSignalTransduction',s("The","process","in","which","a","SLIT","protein","causes","activation","of","the","receptor",",","Roundabout","(","ROBO",")"),4082214). assertion_content_comment('tOboGo_InitiationOfSatelliteCellActivationByGrowthFactorSignallingInvolvedInSkeletalMuscleRegeneration',s("Signalling","between","growth","factors","and","their","receptors","that","results","in","the","activation","of","satellite","cell",",","where","this","process","is","involved","in","skeletal","muscle","regeneration",".","Satellite","cells","are","quiescent","cells","that","are","located","between","the","basal","lamina","and","the","plasmalemma","of","the","muscle","fiber",",","which","are","the","main","contributors","to","postnatal","muscle","growth",".","In","adult","muscle",",","satellite","cells","become","activated","to","divide","and","differentiate","in","response","to","muscle","damage","."),4321134). assertion_content_comment('tOboGo_InitiationOfSignalTransduction',s("The","process","in","which","a","signal","causes","activation","of","a","receptor",",","for","example",",","via","a","conformation","change","."),4052322). assertion_content_comment('tOboGo_InitiationOfSymbiontPenetrationPeg',s("The","process","in","which","a","relatively","unspecialized","cell","of","the","symbiont","starts","to","acquire","the","characteristics","of","a","mature","penetration","peg","to","penetrate","into","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4147185). assertion_content_comment('tOboGo_InitiationOfTCellReceptorSignalingByBindingOfAMHCComplexToTCellReceptor',s("The","process","in","which","binding","of","an","MHC","complex","to","T","cell","receptor","causes","activation","of","T","cell","receptor","signaling","."),4347085). assertion_content_comment('tOboGo_InitiationOfTCellReceptorSignaling',s("The","process","in","which","a","signal","causes","activation","of","T","cell","receptor","signaling","."),4052330). assertion_content_comment('tOboGo_InitiationOfViralInfection',s("The","set","of","processes","involved","in","the","start","of","virus","infection","of","cells","."),4045469). assertion_content_comment('tOboGo_InjectionOfSubstanceInToOtherOrganism',s("The","process","of","forcing","a","substance","into","another","organism",",","either","by","penetrating","the","skin","of","the","other","organism","or","by","applying","the","substance","externally","to","a","sensitive","tissue","such","as","those","that","surround","the","eyes","."),4380748). assertion_content_comment('tOboGo_InnateImmuneResponseActivatingCellSurfaceReceptorSignalingPathway',s("Any","series","of","molecular","signals","leading","to","activation","of","the","innate","immune","response","generated","as","a","consequence","of","binding","to","a","cell","surface","receptor","."),4377590). assertion_content_comment('tOboGo_InnateImmuneResponseInMucosa',s("Any","process","of","the","innate","immune","response","that","takes","place","in","the","mucosal","tissues","."),4377692). assertion_content_comment('tOboGo_InnateImmuneResponse',s("Innate","immune","responses","are","defense","responses","mediated","by","germline","encoded","components","that","directly","recognize","components","of","potential","pathogens","."),3986122). assertion_content_comment('tOboGo_InnerAcrosomalMembrane',s("The","acrosomal","membrane","region","that","underlies","the","acrosomal","vesicle","and","is","located","toward","the","sperm","nucleus",".","This","region","is","responsible","for","molecular","interactions","allowing","the","sperm","to","penetrate","the","zona","pellucida","and","fuses","with","the","egg","plasma","membrane","."),3990269). assertion_content_comment('tOboGo_InnerCellMassCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","inner","cell","mass","cell","."),3986934). assertion_content_comment('tOboGo_InnerCellMassCellFateCommitment',s("The","cell","fate","commitment","of","precursor","cells","that","will","become","inner","cell","mass","cells","."),3986945). assertion_content_comment('tOboGo_InnerCellMassCellProliferation',s("The","proliferation","of","cells","in","the","inner","cell","mass","."),3986989). assertion_content_comment('tOboGo_InnerCellMassCellularMorphogenesis',s("The","morphogenesis","of","cells","in","the","inner","cell","mass","."),3986968). assertion_content_comment('tOboGo_InnerEarDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","inner","ear","over","time",",","from","its","formation","to","the","mature","structure","."),3992724). assertion_content_comment('tOboGo_InnerEarMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","inner","ear","are","generated","and","organized",".","The","inner","ear","is","the","structure","in","vertebrates","that","contains","the","organs","of","balance","and","hearing",".","It","consists","of","soft","hollow","sensory","structures","(","the","membranous","labyrinth",")","containing","fluid","(","endolymph",")","surrounded","by","fluid","(","perilymph",")","and","encased","in","a","bony","cavity","(","the","bony","labyrinth",")","It","consists","of","two","chambers",",","the","sacculus","and","utriculus",",","from","which","arise","the","cochlea","and","semicircular","canals","respectively","."),3992726). assertion_content_comment('tOboGo_InnerEarReceptorCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","inner","ear","receptor","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","specific","fate","."),3992794). assertion_content_comment('tOboGo_InnerEarReceptorCellDifferentiationInvolvedInInnerEarSensoryEpitheliumRegeneration',s("Differentiation","of","new","inner","ear","sensory","hair","cells","to","replace","those","lost","or","destroyed","by","injury","."),4130556). assertion_content_comment('tOboGo_InnerEarReceptorCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells",",","acquire","specialized","structural","and/or","functional","features","of","inner","ear","receptor","cells",".","Inner","ear","receptor","cells","are","mechanorecptors","found","in","the","inner","ear","responsible","for","transducing","signals","involved","in","balance","and","sensory","perception","of","sound","."),3992791). assertion_content_comment('tOboGo_InnerEarReceptorCellFateCommitment',s("The","process","in","which","a","cell","becomes","committed","to","become","an","inner","ear","receptor","cell","."),4021551). 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assertion_content_comment('tOboGo_InnerMedullaryCollectingDuctDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","inner","medullary","collecting","duct","over","time",",","from","its","formation","to","the","mature","structure",".","The","inner","medullary","collecting","duct","is","the","portion","of","the","collecting","duct","that","lies","in","the","renal","inner","medulla","."),4158071). assertion_content_comment('tOboGo_InnerMembraneComplex',s("A","membrane","structure","formed","of","two","closely","aligned","lipid","bilayers","that","lie","beneath","the","plasma","membrane","and","form","part","of","the","pellicle","surrounding","an","apicomplexan","parasite","cell","."),4137196). 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assertion_content_comment('tOboGo_InosinateNucleosidaseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","IMP","=","D-ribose","5-phosphate","+","hypoxanthine","."),4374368). assertion_content_comment('tOboGo_InosineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","inosine",",","hypoxanthine","riboside",",","a","nucleoside","found","free","but","not","in","combination","in","nucleic","acids","except","in","the","anticodons","of","some","tRNAs","."),4227508). assertion_content_comment('tOboGo_InosineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","inosine",",","hypoxanthine","riboside",",","a","nucleoside","found","free","but","not","in","combination","in","nucleic","acids","except","in","the","anticodons","of","some","tRNAs","."),4227919). 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assertion_content_comment('tOboGo_InositolHeptakisphosphateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","diphospho-1D-myo-inositol-pentakisphosphate","=","ADP","+","bis","(","diphospho",")","-1D-myo-inositol-tetrakisphosphate",".","The","isomeric","configurations","of","the","diphospho-1D-myo-inositol-pentakisphosphate","(","PP-IP5",")","and","bis","(","diphospho",")","-1D-myo-inositol-tetrakisphosphate","(","bis-PP-IP4",")","are","unknown","."),4338222). assertion_content_comment('tOboGo_InositolHexakisphosphateBinding',s("Interacting","selectively","and","non-covalently","with","inositol","hexakisphosphate","."),4363524). assertion_content_comment('tOboGo_InositolHexakisphosphateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","1D-myo-inositol","1",",","2",",","3",",","4",",","5",",","6-hexakisphosphate","=","ADP","+","diphospho-1D-myo-inositol-pentakisphosphate","(","PP-IP5",";","isomer","unknown",")"),4179418). assertion_content_comment('tOboGo_InositolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","inositol",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","a","growth","factor","for","animals","and","microorganisms","."),4225490). assertion_content_comment('tOboGo_InositolOrPhosphatidylinositolKinaseActivity',s("Catalysis","of","the","phosphorylation","of","myo-inositol","(","1",",","2",",","3",",","5/4",",","6-cyclohexanehexol",")","or","a","phosphatidylinositol","."),4179401). assertion_content_comment('tOboGo_InositolOrPhosphatidylinositolPhosphataseActivity',s("Catalysis","of","the","removal","of","a","phosphate","group","from","phosphorylated","myo-inositol","(","1",",","2",",","3",",","5/4",",","6-cyclohexanehexol",")","or","a","phosphatidylinositol","."),4191191). assertion_content_comment('tOboGo_InositolOrPhosphatidylinositolPhosphorylation',s("The","process","of","introducing","a","phosphate","group","into","inositol","or","a","phosphatidylinositol",".","Inositol","is","the","cyclic","alcohol","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","which","is","widely","distributed","in","nature","and","acts","as","a","growth","factor","in","animals","and","microorganisms","."),4358225). assertion_content_comment('tOboGo_InositolOxygenaseActivity',s("Catalysis","of","the","reaction",":","myo-inositol","+","O","(","2",")","=","D-glucuronate","+","H","(","2",")","O","+","H","(","+",")"),4271820). assertion_content_comment('tOboGo_InositolPhosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","an","inositol","phosphate",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","with","one","or","more","phosphate","groups","attached","."),4034816). assertion_content_comment('tOboGo_InositolPhosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","an","inositol","phosphate",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","with","one","or","more","phosphate","groups","attached","."),4171397). assertion_content_comment('tOboGo_InositolPhosphateDephosphorylation',s("The","process","of","removing","a","phosphate","group","from","any","mono-","or","polyphosphorylated","inositol","."),4340776). assertion_content_comment('tOboGo_InositolPhosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","inositol","phosphate",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","with","one","or","more","phosphate","groups","attached","."),4034800). assertion_content_comment('tOboGo_InositolphosphoceramideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","inositolphosphoceramides",",","any","lipid","with","a","phosphodiester","bridge","between","an","inositol","residue","and","the","ceramide","group","."),4183635). assertion_content_comment('tOboGo_InositolPhosphoceramideSynthaseActivity',s("Catalysis","of","the","reaction",":","phytoceramide","+","inositol","phosphate","=","inositol","phosphoceramide","."),4300084). assertion_content_comment('tOboGo_InositolPhosphoceramideSynthaseComplex',s("A","protein","complex","that","possesses","inositol","phosphoceramide","synthase","activity","and","contains","a","catalytic","subunit","and","a","regulatory","subunit","(","Aur1p","and","Kei1p",",","respectively",",","in","Saccharomyces",")"),4178290). assertion_content_comment('tOboGo_InositolPhosphoceramideSynthaseRegulatorActivity',s("Modulates","the","activity","of","inositol","phosphoceramide","synthase","."),4178279). assertion_content_comment('tOboGo_InositolPhosphorylceramideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","inositol","phosphorylceramides",",","any","lipid","with","a","phosphodiester","bridge","between","an","inositol","residue","and","the","ceramide","group",".","The","phosphate-containing","group","is","the","trivalent","-P","(","O",")","=","and","the","ceramide","group","of","this","lipid","consists","of","phytosphingosine","and","a","hydroxy","C26","fatty","acid","."),4230737). assertion_content_comment('tOboGo_InositolPolyphosphateMultikinaseActivity',s("OBSOLETE",".","Catalysis","of","the","reactions",":","ATP","+","1D-myo-inositol","1",",","4",",","5-trisphosphate","=","ADP","+","1D-myo-inositol","1",",","4",",","5",",","6-tetrakisphosphate",",","and","ATP","+","1D-myo-inositol","1",",","4",",","5",",","6-tetrakisphosphate","=","ADP","+","1D-myo-inositol","1",",","3",",","4",",","5",",","6-pentakisphosphate","."),4269055). assertion_content_comment('tOboGo_InositolPyrophosphateSynthaseActivity',s("Catalysis","of","the","phosphorylation","of","inositol","phosphates","which","possess","diphosphate","bonds","."),4179415). assertion_content_comment('tOboGo_InositolTetrakisphosphateKinaseActivity',s("Catalysis","of","the","reaction",":","inositol","tetrakisphosphate","+","ATP","=","inositol","pentakisphosphate","+","ADP","."),4280166). assertion_content_comment('tOboGo_InositolTrisphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","inositol","trisphosphate",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","with","three","phosphate","groups","attached","."),4063753). assertion_content_comment('tOboGo_InositolTrisphosphateKinaseActivity',s("Catalysis","of","the","reaction",":","inositol","trisphosphate","+","ATP","=","inositol","tetrakisphosphate","+","ADP","."),4253769). assertion_content_comment('tOboGo_InositolTrisphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","myo-inositol","phosphate",",","1",",","2",",","3",",","4",",","5",",","6-cyclohexanehexol",",","with","three","phosphate","groups","attached","."),4063746). assertion_content_comment('tOboGo_InositolTrisphosphatePhosphataseActivity',s("Catalysis","of","the","removal","of","one","of","the","three","phosphate","groups","of","an","inositol","trisphosphate","."),4191922). assertion_content_comment('tOboGo_InsecticideCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","insecticides",",","chemicals","used","to","kill","insects","."),4313656). assertion_content_comment('tOboGo_InsecticideMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","insecticides",",","chemicals","used","to","kill","insects","."),4040961). assertion_content_comment('tOboGo_InsecticideResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228876). assertion_content_comment('tOboGo_InsecticideSusceptibilityResistance',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4304403). assertion_content_comment('tOboGo_Insemination',s("The","introduction","of","semen","or","sperm","into","the","genital","tract","of","a","female","."),4018868). assertion_content_comment('tOboGo_InsertionOrDeletionEditing',s("OBSOLETE",".","The","insertion","into","or","deletion","from","an","RNA","molecule","of","nucleotide","residues","not","encoded","in","DNA",";","takes","place","during","or","after","transcription","."),4305243). assertion_content_comment('tOboGo_InsolubleFraction',s("That","fraction","of","cells",",","prepared","by","disruptive","biochemical","methods",",","that","is","not","soluble","in","water","."),3988367). assertion_content_comment('tOboGo_InstarLarvalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","larva","over","time",",","from","its","formation","to","the","mature","structure",".","This","begins","with","the","newly","hatched","first-instar","larva",",","through","its","maturation","to","the","end","of","the","last","larval","stage",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4017472). assertion_content_comment('tOboGo_InstarLarvalOrPupalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","instar","larva","or","pupa","over","time",",","from","its","formation","to","the","mature","structure",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),3982553). assertion_content_comment('tOboGo_InstarLarvalOrPupalMorphogenesis',s("The","process",",","occurring","during","instar","larval","or","pupal","development",",","by","which","anatomical","structures","are","generated","and","organized","."),3982555). assertion_content_comment('tOboGo_InstrumentalAggressiveBehavior',s("Aggressive","behavior","directed","towards","obtaining","some","goal",",","considered","to","be","a","learned","response","to","a","situation","."),4375517). assertion_content_comment('tOboGo_InsulinBinding',s("Interacting","selectively","and","non-covalently","with","insulin",",","a","polypeptide","hormone","produced","by","the","islets","of","Langerhans","of","the","pancreas","in","mammals",",","and","by","the","homologous","organs","of","other","organisms","."),4325447). assertion_content_comment('tOboGo_InsulinControlElementActivatorComplex',s("Transcription","factor","complex","that","binds","to","the","insulin","control","element","(","ICE",")",",","a","DNA","sequence","element","found","within","the","5","'","-flanking","region","of","the","insulin","gene",",","and","activates","ICE-mediated","transcription","."),4311685). assertion_content_comment('tOboGo_InsulinProcessing',s("The","formation","of","mature","insulin","by","proteolysis","of","the","precursor","preproinsulin",".","The","signal","sequence","is","first","cleaved","from","preproinsulin","to","form","proinsulin",";","proinsulin","is","then","cleaved","to","release","the","C","peptide",",","leaving","the","A","and","B","chains","of","mature","insulin","linked","by","disulfide","bridges","."),4306683). assertion_content_comment('tOboGo_InsulinReceptorActivity',s("Combining","with","insulin","to","initiate","a","change","in","cell","activity","."),4213809). assertion_content_comment('tOboGo_InsulinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","insulin","receptor","."),4217236). assertion_content_comment('tOboGo_InsulinReceptorComplex',s("A","disulfide-bonded",",","heterotetrameric","receptor","complex",".","The","alpha","chains","are","entirely","extracellular",",","while","each","beta","chain","has","one","transmembrane","domain",".","The","ligand","binds","to","the","alpha","subunit","extracellular","domain","and","the","kinase","is","associated","with","the","beta","subunit","intracellular","domain","."),4008234). assertion_content_comment('tOboGo_InsulinReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","the","insulin","receptor","binding","to","insulin","."),4082287). assertion_content_comment('tOboGo_InsulinReceptorSubstrateBinding',s("Interacting","selectively","and","non-covalently","with","any","of","the","insulin","receptor","substrate","(","IRS",")","proteins",",","adaptor","proteins","that","bind","to","the","transphosphorylated","insulin","and","insulin-like","growth","factor","receptors",",","are","themselves","phosphorylated","and","in","turn","recruit","SH2","domain-containing","signaling","molecules","to","form","a","productive","signaling","complex","."),4325435). assertion_content_comment('tOboGo_InsulinSecretionInvolvedInCellularResponseToGlucoseStimulus',s("The","regulated","release","of","proinsulin","from","secretory","granules","(","B","granules",")","in","the","B","cells","of","the","pancreas",";","accompanied","by","cleavage","of","proinsulin","to","form","mature","insulin",",","in","response","to","a","glucose","stimulus","."),4081365). assertion_content_comment('tOboGo_InsulinSecretion',s("The","regulated","release","of","proinsulin","from","secretory","granules","(","B","granules",")","in","the","B","cells","of","the","pancreas",";","accompanied","by","cleavage","of","proinsulin","to","form","mature","insulin","."),4057045). assertion_content_comment('tOboGo_Insulin',s("OBSOLETE",".","A","polypeptide","hormone","that","stimulates","glucose","uptake","by","muscle","and","adipose","tissue",",","and","promotes","glycogenesis",",","lipogenesis","and","the","synthesis","of","proteins","and","nucleic","acids","."),4303370). assertion_content_comment('tOboGo_InsulysinActivity',s("OBSOLETE",".","Catalysis","of","the","degradation","of","insulin",",","glucagon","and","other","polypeptides",".","No","action","on","proteins","."),4210047). assertion_content_comment('tOboGo_IntegralToCellOuterMembrane',s("Located","such","that","some","or","all","of","the","gene","product","itself","penetrates","at","least","one","phospholipid","bilayer","of","the","external","outer","membrane","of","the","cell",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4292520). assertion_content_comment('tOboGo_IntegralToChloroplastInnerMembrane',s("Located","such","that","some","or","all","of","the","gene","product","itself","penetrates","at","least","one","phospholipid","bilayer","of","the","chloroplast","inner","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4058720). 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assertion_content_comment('tOboGo_IntegralToPeroxisomalMembrane',s("Penetrating","at","least","one","phospholipid","bilayer","of","a","peroxisomal","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4219923). assertion_content_comment('tOboGo_IntegralToPlasmaMembrane',s("Penetrating","at","least","one","phospholipid","bilayer","of","a","plasma","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),3973208). assertion_content_comment('tOboGo_IntegralToPlastidInnerMembrane',s("Penetrating","at","least","one","phospholipid","bilayer","of","a","plastid","inner","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4058716). assertion_content_comment('tOboGo_IntegralToPlastidMembrane',s("Penetrating","at","least","one","phospholipid","bilayer","of","a","plastid","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4058660). assertion_content_comment('tOboGo_IntegralToPlastidOuterMembrane',s("Penetrating","at","least","one","phospholipid","bilayer","of","a","plastid","outer","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4058663). assertion_content_comment('tOboGo_IntegralToSynapticVesicleMembrane',s("Penetrating","at","least","one","phospholipid","bilayer","of","a","synaptic","vesicle","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4048819). assertion_content_comment('tOboGo_IntegralToThylakoidMembrane',s("Penetrating","at","least","one","phospholipid","bilayer","of","a","thylakoid","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4058752). assertion_content_comment('tOboGo_IntegralToVacuolarMembrane',s("Located","such","that","some","or","all","of","the","gene","product","itself","penetrates","at","least","one","phospholipid","bilayer","of","the","vacuolar","membrane",".","May","also","refer","to","the","state","of","being","buried","in","the","bilayer","with","no","exposure","outside","the","bilayer","."),4172852). assertion_content_comment('tOboGo_IntegraseActivity',s("Catalysis","of","the","integration","of","one","segment","of","DNA","into","another","."),4247995). 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assertion_content_comment('tOboGo_InteractionWithHostViaProteinSecretedBySecComplex',s("An","interaction","with","the","host","organism","mediated","by","a","substance","secreted","by","the","symbiont","organism","by","a","Sec","complex",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080382). assertion_content_comment('tOboGo_InteractionWithHostViaProteinSecretedByTatComplex',s("An","interaction","with","the","host","organism","mediated","by","a","substance","secreted","by","the","symbiont","organism","by","a","Tat","complex",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080403). 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assertion_content_comment('tOboGo_InteractionWithSymbiontViaSecretedSubstanceInvolvedInSymbioticInteraction',s("An","interaction","with","the","symbiont","organism","mediated","by","a","substance","secreted","by","the","other","(","host",")","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4080270). assertion_content_comment('tOboGo_IntercalaryHeterochromatin',s("Any","of","the","regions","of","heterochromatin","that","form","a","reproducible","set","of","dense","bands","scattered","along","the","euchromatic","arms","in","polytene","chromosomes","."),4219698). assertion_content_comment('tOboGo_IntercalaryLeafletMorphogenesis',s("The","process","in","which","the","intercalary","leaflet","attains","its","shape",".","An","intercalary","leaflet","is","a","leaflet","that","develops","between","primary","leaflets","."),4161061). assertion_content_comment('tOboGo_IntercalatedDisc',s("A","complex","cell-cell","junction","at","which","myofibrils","terminate","in","cardiomyocytes",";","mediates","mechanical","and","electrochemical","integration","between","individual","cardiomyocytes",".","The","intercalated","disc","contains","regions","of","tight","mechanical","attachment","(","fasciae","adherentes","and","desmosomes",")","and","electrical","coupling","(","gap","junctions",")","between","adjacent","cells","."),4008069). assertion_content_comment('tOboGo_IntercellularBridgeOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","intracellular","bridge",".","An","intracellular","bridge","is","a","direct","link","between","the","cytoplasms","of","sister","cells","that","allows","cells","to","communicate","with","one","another","."),4018827). assertion_content_comment('tOboGo_IntercellularBridge',s("A","direct","link","between","the","cytoplasms","of","sister","cells","that","allows","cells","to","communicate","with","one","another",".","Germline","intercellular","bridges","facilitate","the","passage","of","cytoplasmic","components","between","cells","during","development",".","Intercellular","bridges","have","also","been","found","connecting","somatic","cells","."),4072015). assertion_content_comment('tOboGo_IntercellularCanaliculus',s("An","extremely","narrow","tubular","channel","located","between","adjacent","cells",".","An","instance","of","this","is","the","secretory","canaliculi","occurring","between","adjacent","parietal","cells","in","the","gastric","mucosa","of","vertebrates","."),4358696). assertion_content_comment('tOboGo_IntercellularTransport',s("The","movement","of","substances","between","cells","in","a","multicellular","organism","."),4332760). assertion_content_comment('tOboGo_InterchromatinGranule',s("A","class","of","nuclear","body","measuring","20-25","nm","in","diameter","and","distributed","throughout","the","interchromatin","space",",","linked","together","by","thin","fibrils",".","They","are","believed","to","be","storage","centers","for","various","snRNAs",",","snRNPs",",","serine/arginine-rich","proteins","and","RNA","polymerase","II",".","A","typical","mammalian","cell","contains","25-50","clusters","of","interchromatin","granules",".","Interchromatin","granule","clusters","do","not","contain","the","heterogeneous","nuclear","RNA-binding","proteins","(","hnRNPs",")"),4381809). assertion_content_comment('tOboGo_InterferonBinding',s("Interacting","selectively","and","non-covalently","with","an","interferon",",","a","protein","produced","by","the","immune","systems","of","many","animals","in","response","to","a","challenge","by","a","foreign","agent","."),4198252). assertion_content_comment('tOboGo_InterferonReceptorActivity',s("Combining","with","an","interferon","to","initiate","a","change","in","cell","activity","."),4198255). assertion_content_comment('tOboGo_IntergenicNuclearMRNATransSplicing',s("The","joining","together","of","two","independently","transcribed","RNAs","from","two","different","genes",",","each","of","which","also","produces","mRNA","(","s",")","via","cis-splicing","."),4362958). assertion_content_comment('tOboGo_InterkineticNuclearMigration',s("The","movement","of","the","nucleus","of","the","ventricular","zone","cell","between","the","apical","and","the","basal","zone","surfaces",".","Mitosis","occurs","when","the","nucleus","is","near","the","apical","surface",",","that","is",",","the","lumen","of","the","ventricle","."),4053381). assertion_content_comment('tOboGo_IntermediateFilamentAssociatedProtein',s("OBSOLETE",".","Proteins","that","associate","with","intermediate","filaments","and","function","in","the","supramolecular","organization","of","cellular","intermediate","filament","networks","."),4383304). assertion_content_comment('tOboGo_IntermediateFilamentBinding',s("Interacting","selectively","and","non-covalently","with","an","intermediate","filament",",","a","distinct","elongated","structure",",","characteristically","10","nm","in","diameter",",","that","occurs","in","the","cytoplasm","of","higher","eukaryotic","cells",".","Intermediate","filaments","form","a","fibrous","system",",","composed","of","chemically","heterogeneous","subunits","and","involved","in","mechanically","integrating","the","various","components","of","the","cytoplasmic","space","."),4237948). assertion_content_comment('tOboGo_IntermediateFilamentBundleAssembly',s("The","formation","of","the","bundles","of","intermediate","filaments",",","known","as","tonofilaments",".","Intermediate","filament-associated","proteins","(","IFAPs",")","cross-link","intermediate","filaments","with","one","another",",","forming","a","bundle","or","a","network",",","and","with","other","cell","structures",",","including","the","plasma","membrane",".","The","organization","of","intermediate","filaments","and","their","supportive","function","in","various","cells","types","depends","in","large","part","on","their","linkage","to","other","cell","structures","via","IFAPs","."),4300114). assertion_content_comment('tOboGo_IntermediateFilamentCytoskeletonOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","intermediate","filaments","and","their","associated","proteins","."),4051358). assertion_content_comment('tOboGo_IntermediateFilamentCytoskeleton',s("Cytoskeletal","structure","made","from","intermediate","filaments",",","typically","organized","in","the","cytosol","as","an","extended","system","that","stretches","from","the","nuclear","envelope","to","the","plasma","membrane",".","Some","intermediate","filaments","run","parallel","to","the","cell","surface",",","while","others","traverse","the","cytosol",";","together","they","form","an","internal","framework","that","helps","support","the","shape","and","resilience","of","the","cell","."),4007053). assertion_content_comment('tOboGo_IntermediateFilamentDepolymerization',s("Disassembly","of","intermediate","filaments","by","the","removal","of","component","monomers","from","a","filament","."),4051365). assertion_content_comment('tOboGo_IntermediateFilamentOrganization',s("Control","of","the","spatial","distribution","of","intermediate","filaments",";","includes","organizing","filaments","into","meshworks",",","bundles",",","or","other","structures",",","as","by","cross-linking","."),4300103). assertion_content_comment('tOboGo_IntermediateFilamentPolymerizationOrDepolymerization',s("Assembly","or","disassembly","of","intermediate","filaments","by","the","addition","or","removal","of","component","parts","from","a","filament","."),4051362). assertion_content_comment('tOboGo_IntermediateFilamentPolymerization',s("Assembly","of","intermediate","filaments","by","the","addition","of","component","monomers","to","a","filament",".","Polymerization","of","intermediate","filament","proteins","results","from","interactions","among","several","distinct","binding","sites","on","the","constituent","proteins",".","Nuclear","lamin","head-to-tail","polymers","arise","from","one","such","interaction",".","Deletion","analysis","localized","the","binding","sites","to","the","ends","of","the","rod","domain","that","are","highly","conserved","among","all","intermediate","filament","proteins",".","Data","indicate","that","one","type","of","interaction","in","intermediate","filament","protein","polymerization","is","the","longitudinal","binding","of","dimers","via","the","conserved","end","segments","of","the","coiled-coil","rod","domain","."),4051396). assertion_content_comment('tOboGo_IntermediateFilament',s("A","cytoskeletal","structure","that","forms","a","distinct","elongated","structure",",","characteristically","10","nm","in","diameter",",","that","occurs","in","the","cytoplasm","of","eukaryotic","cells",".","Intermediate","filaments","form","a","fibrous","system",",","composed","of","chemically","heterogeneous","subunits","and","involved","in","mechanically","integrating","the","various","components","of","the","cytoplasmic","space",".","Intermediate","filaments","may","be","divided","into","five","chemically","distinct","classes",":","Type","I",",","acidic","keratins",";","Type","II",",","basic","keratins",";","Type","III",",","including","desmin",",","vimentin","and","others",";","Type","IV",",","neurofilaments","and","related","filaments",";","and","Type","V",",","lamins","."),4007055). assertion_content_comment('tOboGo_IntermediateLayerOfSpindlePoleBody',s("Structure","between","the","central","and","outer","plaques","of","the","spindle","pole","body","."),4007205). assertion_content_comment('tOboGo_IntermediateMesodermalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","an","intermediate","mesoderm","cell","."),4101997). assertion_content_comment('tOboGo_IntermediateMesodermalCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","an","intermediate","mesoderm","cell","."),4102000). assertion_content_comment('tOboGo_IntermediateMesodermalCellFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","intermediate","mesoderm","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4102093). assertion_content_comment('tOboGo_IntermediateMesodermalCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","intermediate","mesoderm","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4102003). assertion_content_comment('tOboGo_IntermediateMesodermDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","intermediate","mesoderm","over","time",",","from","its","formation","to","the","mature","structure",".","The","intermediate","mesoderm","is","located","between","the","lateral","mesoderm","and","the","paraxial","mesoderm",".","It","develops","into","the","kidney","and","gonads","."),4101991). assertion_content_comment('tOboGo_IntermediateMesodermFormation',s("The","process","that","gives","rise","to","the","intermediate","mesoderm",".","This","process","pertains","to","the","initial","formation","of","the","structure","from","unspecified","parts","."),4101995). assertion_content_comment('tOboGo_IntermediateMesodermMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","intermediate","mesoderm","are","generated","and","organized","."),4101993). assertion_content_comment('tOboGo_IntermediateMesodermStructuralOrganization',s("The","process","that","contributes","to","the","act","of","creating","the","structural","organization","of","the","intermediate","mesoderm",".","This","process","pertains","to","the","physical","shaping","of","a","rudimentary","structure","."),4102082). assertion_content_comment('tOboGo_IntermediateReticularFormationDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","intermediate","reticular","formation","over","time",",","from","its","formation","to","the","mature","structure","."),4042710). assertion_content_comment('tOboGo_IntermembraneTransport',s("The","directed","movement","of","substances","between","the","intracellular","membranes","of","a","cell",",","for","example",",","the","transfer","of","glycolipids","from","the","endoplasmic","reticulum","to","other","cellular","membrane","structures","in","which","they","reside","."),4358605). assertion_content_comment('tOboGo_InternalGenitaliaMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","internal","genitalia","are","generated","and","organized",".","The","internal","genitalia","are","the","internal","sex","organs","such","as","the","uterine","tube",",","the","uterus","and","the","vagina","in","female","mammals",",","and","the","testis",",","seminal","vesicle",",","ejaculatory","duct","and","prostate","in","male","mammals","."),4382691). assertion_content_comment('tOboGo_InternalizationReceptorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4296730). assertion_content_comment('tOboGo_InternalMammaryGlandBudEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","epithelial","cell","of","the","mammary","placode","becomes","an","internal","epithelial","cell","of","the","mammary","gland","bud",".","Internal","cells","are","small","and","of","irregular","shape","."),4160987). assertion_content_comment('tOboGo_InternalProteinAminoAcidAcetylation',s("The","addition","of","an","acetyl","group","to","a","non-terminal","amino","acid","in","a","protein","."),4072846). assertion_content_comment('tOboGo_InternalSideOfCellOuterMembrane',s("The","side","of","the","outer","membrane","that","faces","the","periplasm","of","the","cell","."),4062397). assertion_content_comment('tOboGo_InternalSideOfPlasmaMembrane',s("The","side","of","the","plasma","membrane","that","faces","the","cytoplasm","."),4062159). assertion_content_comment('tOboGo_InterneuronMigrationFromTheSubpalliumToTheCortex',s("The","directed","movement","of","interneurons","from","the","subpallium","to","the","cortex","during","forebrain","development","."),4050733). assertion_content_comment('tOboGo_InternodePatterning',s("Determines","the","spacing","between","two","shoot","nodes",".","A","shoot","node","is","the","region","of","the","shoot","where","the","spikelet",",","flower",",","floret",",","branch",",","bud","and/or","leaves","are","attached","."),4148863). assertion_content_comment('tOboGo_InternodeRegionOfAxon',s("An","axon","part","that","is","located","between","the","nodes","of","Ranvier","and","surrounded","by","compact","myelin","sheath","."),4066508). assertion_content_comment('tOboGo_InterphaseChromosome',s("OBSOLETE",".","A","chromosome","found","in","the","cell","during","interphase","of","the","cell","cycle",".","Chromosomes","are","usually","decondensed","during","interphase","and","each","long","DNA","molecule","in","a","chromosome","is","divided","into","a","large","number","of","discrete","domains","that","are","folded","differently","."),4219781). assertion_content_comment('tOboGo_InterphaseMicrotubuleNucleationByInterphaseMicrotubuleOrganizingCenter',s("The","'","de","novo","'","formation","of","a","microtubule","by","the","interphase","microtubule","organizing","center","during","interphase",",","the","stage","of","cell","cycle","between","successive","rounds","of","chromosome","segregation","."),4118172). assertion_content_comment('tOboGo_InterphaseMicrotubuleOrganizingCenterAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components",",","including","gamma-tubulin","and","other","proteins",",","to","form","an","interphase","microtubule","organizing","center","."),4319187). assertion_content_comment('tOboGo_InterphaseMicrotubuleOrganizingCenter',s("A","microtubule","organizing","center","found","in","interphase","cells",",","which","organize","a","longitudinal","array","of","three","to","five","MT","bundles","from","the","nuclear","envelope","during","interphase",".","Each","MT","bundle","is","composed","of","two","to","seven","MTs","arranged","in","an","antiparallel","configuration",",","with","the","dynamic","MT","plus","ends","extending","toward","the","cell","tips","and","stable","minus","ends","near","the","nucleus","."),4107702). assertion_content_comment('tOboGo_InterphaseOfMeioticCellCycle',s("Interphase","occurring","as","part","of","the","meiotic","cell","cycle",".","Canonically",",","interphase","is","the","stage","of","the","cell","cycle","during","which","the","biochemical","and","physiologic","functions","of","the","cell","are","performed","and","replication","of","chromatin","occurs",".","A","meiotic","cell","cycle","is","one","in","which","canonically","a","cell","replicates","to","produce","four","offspring","with","half","the","chromosomal","content","of","the","progenitor","cell","."),4117942). assertion_content_comment('tOboGo_InterphaseOfMitoticCellCycle',s("Interphase","occurring","as","part","of","the","mitotic","cell","cycle",".","Canonically",",","interphase","is","the","stage","of","the","cell","cycle","during","which","the","biochemical","and","physiologic","functions","of","the","cell","are","performed","and","replication","of","chromatin","occurs",".","A","mitotic","cell","cycle","is","one","which","canonically","comprises","four","successive","phases","called","G1",",","S",",","G2",",","and","M","and","includes","replication","of","the","genome","and","the","subsequent","segregation","of","chromosomes","into","daughter","cells","."),3970769). assertion_content_comment('tOboGo_Interphase',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","interphase",",","the","stage","of","cell","cycle","between","successive","rounds","of","chromosome","segregation",".","Canonically",",","interphase","is","the","stage","of","the","cell","cycle","during","which","the","biochemical","and","physiologic","functions","of","the","cell","are","performed","and","replication","of","chromatin","occurs","."),3970764). assertion_content_comment('tOboGo_InterphotoreceptorMatrix',s("A","specialized","extracellularc","matrix","that","surrounds","the","photoreceptors","of","the","retina","and","lies","between","them","and","the","apical","surface","of","the","retinal","pigment","epithelium",".","The","IPM","has","been","implicated","in","several","important","activities","required","for","photoreceptor","function","and","maintenance","."),4347803). assertion_content_comment('tOboGo_InterspeciesInteractionBetweenOrganisms',s("Any","process","in","which","an","organism","has","an","effect","on","an","organism","of","a","different","species","."),3985618). assertion_content_comment('tOboGo_InterspeciesQuorumSensing',s("The","process","in","which","a","community","of","single-celled","organisms","of","different","species","monitors","population","density","by","detecting","the","concentration","of","small","diffusible","signal","molecules","."),4121252). assertion_content_comment('tOboGo_InterstitialCollagenaseActivity',s("OBSOLETE",".","Catalysis","of","the","preferential","cleavage","of","one","bond","in","native","collagen",".","Cleavage","of","the","triple","helix","of","collagen","at","about","three-quarters","of","the","length","of","the","molecule","from","the","N-terminus",",","at","Gly775-Ile776","in","the","alpha-1","(","I",")","chain",".","Cleaves","synthetic","substrates","and","alpha-macroglobulins","at","bonds","where","P1","'","is","a","hydrophobic","residue","."),4210067). assertion_content_comment('tOboGo_InterstitialMatrix',s("A","type","of","extracellular","matrix","found","in","interstitial","connective","tissue",",","characterized","by","the","presence","of","fibronectins",",","proteoglycans",",","and","types","I",",","III",",","V",",","VI",",","VII","and","XII","collagens","."),4220019). assertion_content_comment('tOboGo_IntestinalAbsorption',s("Any","process","in","which","nutrients","are","taken","up","from","the","contents","of","the","intestine","."),4035293). assertion_content_comment('tOboGo_IntestinalCholesterolAbsorption',s("Uptake","of","cholesterol","into","the","blood","by","absorption","from","the","small","intestine","."),4048337). assertion_content_comment('tOboGo_IntestinalEpithelialCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","columnar/cuboidal","epithelial","cell","of","the","intestine","over","time",",","from","its","formation","to","the","mature","structure","."),4117111). assertion_content_comment('tOboGo_IntestinalEpithelialCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","columnar/cuboidal","epithelial","cell","of","the","intestine","."),4117101). assertion_content_comment('tOboGo_IntestinalEpithelialCellMaturation',s("The","developmental","process",",","independent","of","morphogenetic","(","shape",")","change",",","that","is","required","for","a","columna/cuboidal","epithelial","cell","of","the","intestine","to","attain","its","fully","functional","state",".","A","columnar/cuboidal","epithelial","cell","of","the","intestine","mature","as","they","migrate","from","the","intestinal","crypt","to","the","villus","."),4117141). assertion_content_comment('tOboGo_IntestinalEpithelialStructureMaintenance',s("A","tissue","homeostatic","process","required","for","the","maintenance","of","the","structure","of","the","intestinal","epithelium","."),4110782). assertion_content_comment('tOboGo_IntestinalLipidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","into","fatty","acids","and","monoglycerides","of","lipids","in","the","small","intestine",".","Lipids","are","broken","down","by","lipases","released","by","the","pancreas","."),4288042). assertion_content_comment('tOboGo_IntestinalPhytosterolAbsorption',s("Any","process","in","which","phytosterols","are","taken","up","from","the","contents","of","the","intestine","."),4035295). assertion_content_comment('tOboGo_IntestineSmoothMuscleContraction',s("A","process","in","which","force","is","generated","within","smooth","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","This","process","occurs","in","the","intestine",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","intestine","is","the","section","of","the","alimentary","canal","from","the","stomach","to","the","anal","canal",".","It","includes","the","large","intestine","and","small","intestine","."),4321210). assertion_content_comment('tOboGo_Intine',s("The","innermost","of","the","major","layers","of","the","pollen","grain","wall","which","underlies","the","exine","and","borders","the","cytoplasm","."),4095401). assertion_content_comment('tOboGo_IntracellularAccumulationOfGlycerol',s("The","accumulation","of","glycerol","within","a","cell",",","for","example","by","increased","glycerol","biosynthesis","combined","with","decreased","permeability","of","the","cell","membrane","to","glycerol",",","in","response","to","the","detection","of","a","hyperosmotic","environment","."),4011278). assertion_content_comment('tOboGo_IntracellularAuxinTransport',s("The","directed","movement","of","auxins","within","a","cell",".","Auxins","are","a","group","of","plant","hormones","that","regulates","aspects","of","plant","growth","."),4181108). assertion_content_comment('tOboGo_IntracellularCalciumActivatedChlorideChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","chloride","by","a","channel","that","opens","in","response","to","stimulus","by","a","calcium","ion","or","ions",".","Transport","by","a","channel","involves","catalysis","of","facilitated","diffusion","of","a","solute","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel",",","without","evidence","for","a","carrier-mediated","mechanism","."),4217633). assertion_content_comment('tOboGo_IntracellularCAMPActivatedCationChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","cation","by","a","channel","that","opens","when","intracellular","cAMP","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4217716). assertion_content_comment('tOboGo_IntracellularCanaliculus',s("An","apical","plasma","membrane","part","that","forms","a","narrow","enfolded","luminal","membrane","channel",",","lined","with","numerous","microvilli",",","that","appears","to","extend","into","the","cytoplasm","of","the","cell",".","A","specialized","network","of","intracellular","canaliculi","is","a","characteristic","feature","of","parietal","cells","of","the","gastric","mucosa","in","vertebrates","."),4099233). assertion_content_comment('tOboGo_IntracellularCGMPActivatedCationChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","cation","by","a","channel","that","opens","when","intracellular","cGMP","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4217707). assertion_content_comment('tOboGo_IntracellularCholesterolTransport',s("The","directed","movement","of","cholesterol",",","cholest-5-en-3-beta-ol",",","within","cells","."),4056494). assertion_content_comment('tOboGo_IntracellularCopperIonTransporter',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4216692). assertion_content_comment('tOboGo_IntracellularCopperIonTransport',s("The","directed","movement","of","copper","(","Cu",")","ions","within","a","cell","."),4290008). assertion_content_comment('tOboGo_IntracellularCyclicNucleotideActivatedCationChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","cation","by","a","channel","that","opens","when","intracellular","cyclic","nucleotide","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4217677). assertion_content_comment('tOboGo_IntracellularCyclicNucleotideActivatedCationChannelComplex',s("A","protein","complex","that","forms","a","transmembrane","channel","through","which","cations","ions","may","pass","in","response","to","an","intracellular","cyclic","nucleotide","binding","to","the","channel","complex","or","one","of","its","constituent","parts","."),4269298). assertion_content_comment('tOboGo_IntracellularDefenseResponse',s("A","physiological","defense","response","which","occurs","intracellularly","."),4383060). assertion_content_comment('tOboGo_IntracellularDistributionOfMitochondria',s("Any","process","that","establishes","the","spatial","arrangement","of","mitochondria","within","the","cell","."),4334601). assertion_content_comment('tOboGo_IntracellularFerritinComplex',s("A","ferritin","complex","located","in","the","cell",".","Intracellular","ferritin","complexes","contain","24","subunits",",","in","a","mixture","of","L","(","light",")","chains","and","H","(","heavy",")","chains","."),4246889). assertion_content_comment('tOboGo_IntracellularImmatureSpore',s("A","cell","or","part","of","the","cell","that","constitutes","an","early","developmental","stage","of","a","spore",",","a","small","reproductive","body","that","is","highly","resistant","to","desiccation","and","heat","and","is","capable","of","growing","into","a","new","organism",",","produced","especially","by","certain","bacteria",",","fungi",",","algae",",","and","nonflowering","plants","."),4006960). assertion_content_comment('tOboGo_IntracellularLipidTransport',s("The","directed","movement","of","lipids","within","cells","."),4056490). assertion_content_comment('tOboGo_IntracellularMRNALocalizationInvolvedInAnteriorPosteriorAxisSpecification',s("Any","process","in","which","mRNA","is","transported","to",",","or","maintained","in",",","a","specific","location","within","the","oocyte","and/or","syncytial","embryo","that","contributes","to","the","specification","of","the","anterior/posterior","axis","."),4019038). assertion_content_comment('tOboGo_IntracellularMRNALocalizationInvolvedInPatternSpecificationProcess',s("Any","process","in","which","mRNA","is","transported","to",",","or","maintained","in",",","a","specific","location","within","an","oocyte","that","results","in","a","pattern","being","established","in","the","embryo","."),4019034). assertion_content_comment('tOboGo_IntracellularMRNALocalization',s("Any","process","in","which","mRNA","is","transported","to",",","or","maintained","in",",","a","specific","location","within","the","cell","."),4019026). assertion_content_comment('tOboGo_IntracellularNucleosideTransmembraneTransporterActivity',s("OBSOLETE",".","Enables","the","directed","movement","of","a","nucleoside",",","a","nucleobase","linked","to","either","beta-D-ribofuranose","(","ribonucleoside",")","or","2-deoxy-beta-D-ribofuranose","(","a","deoxyribonucleotide",")","within","a","cell","."),4346348). assertion_content_comment('tOboGo_IntracellularNucleosideTransport',s("The","directed","movement","of","a","nucleoside",",","a","nucleobase","linked","to","either","beta-D-ribofuranose","(","ribonucleoside",")","or","2-deoxy-beta-D-ribofuranose",",","(","a","deoxyribonucleotide",")",",","within","a","cell","."),4293956). assertion_content_comment('tOboGo_IntracellularOrganelleLumen',s("An","organelle","lumen","that","is","part","of","an","intracellular","organelle","."),3972755). assertion_content_comment('tOboGo_IntracellularOrganellePart',s("A","constituent","part","of","an","intracellular","organelle",",","an","organized","structure","of","distinctive","morphology","and","function",",","occurring","within","the","cell",".","Includes","constituent","parts","of","the","nucleus",",","mitochondria",",","plastids",",","vacuoles",",","vesicles",",","ribosomes","and","the","cytoskeleton","but","excludes","the","plasma","membrane","."),3971770). assertion_content_comment('tOboGo_IntracellularOrganelle',s("Organized","structure","of","distinctive","morphology","and","function",",","occurring","within","the","cell",".","Includes","the","nucleus",",","mitochondria",",","plastids",",","vacuoles",",","vesicles",",","ribosomes","and","the","cytoskeleton",".","Excludes","the","plasma","membrane","."),3971768). assertion_content_comment('tOboGo_IntracellularPart',s("Any","constituent","part","of","the","living","contents","of","a","cell",";","the","matter","contained","within","(","but","not","including",")","the","plasma","membrane",",","usually","taken","to","exclude","large","vacuoles","and","masses","of","secretory","or","ingested","material",".","In","eukaryotes","it","includes","the","nucleus","and","cytoplasm","."),3971392). assertion_content_comment('tOboGo_IntracellularPHElevation',s("Any","process","that","increases","the","internal","pH","of","a","cell",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4286545). assertion_content_comment('tOboGo_IntracellularPHReduction',s("Any","process","that","reduces","the","internal","pH","of","a","cell",",","measured","by","the","concentration","of","the","hydrogen","ion","."),4070011). assertion_content_comment('tOboGo_IntracellularProteinKinaseCascade',s("A","series","of","reactions","that","occur","within","the","cell",",","mediated","by","protein","kinases",",","which","occurs","as","a","result","of","a","single","trigger","reaction","or","compound","."),3972173). assertion_content_comment('tOboGo_IntracellularProteinTransmembraneTransport',s("The","directed","movement","of","proteins","in","a","cell",",","from","one","side","of","a","membrane","to","another","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4014004). assertion_content_comment('tOboGo_IntracellularProteinTransportInOtherOrganismInvolvedInSymbioticInteraction',s("The","directed","movement","of","an","organism","'","s","proteins","within","a","cell","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4045643). assertion_content_comment('tOboGo_IntracellularProteinTransport',s("The","directed","movement","of","proteins","in","a","cell",",","including","the","movement","of","proteins","between","specific","compartments","or","structures","within","a","cell",",","such","as","organelles","of","a","eukaryotic","cell","."),3970262). assertion_content_comment('tOboGo_IntracellularReceptorMediatedSignalingPathway',s("Any","series","of","molecular","signals","initiated","by","a","ligand","binding","to","an","receptor","located","within","a","cell","."),3993055). assertion_content_comment('tOboGo_IntracellularRegionOfHost',s("That","space","within","the","plasma","membrane","of","a","host","cell","."),4041858). assertion_content_comment('tOboGo_IntracellularSequesteringOfIronIon',s("The","process","of","binding","or","confining","iron","ions","in","an","intracellular","area","such","that","they","are","separated","from","other","components","of","a","biological","system","."),4011754). assertion_content_comment('tOboGo_IntracellularSignalTransductionInvolvedInCellSurfaceReceptorLinkedSignaling',s("The","process","in","which","a","signal","is","passed","on","from","a","receptor","at","the","cell","surface","to","downstream","components","within","the","cell",",","which","become","activated","themselves","to","further","propagate","the","signal","and","finally","trigger","a","change","in","the","function","or","state","of","the","cell","."),4016163). assertion_content_comment('tOboGo_IntracellularSignalTransduction',s("The","process","in","which","a","signal","is","passed","on","to","downstream","components","within","the","cell",",","which","become","activated","themselves","to","further","propagate","the","signal","and","finally","trigger","a","change","in","the","function","or","state","of","the","cell","."),3972165). assertion_content_comment('tOboGo_IntracellularSodiumActivatedPotassiumChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","potassium","by","a","channel","that","opens","in","response","to","stimulus","by","a","sodium","ion","or","ions",".","Transport","by","a","channel","involves","catalysis","of","facilitated","diffusion","of","a","solute","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel",",","without","evidence","for","a","carrier-mediated","mechanism",".","Sodium","activated","potassium","channels","have","distinctive","properties",",","including","a","large","single","channel","conductance",",","subconductance","states",",","and","a","block","of","single","channel","currents","at","positive","potentials",",","similar","to","inward","rectification","."),4217643). assertion_content_comment('tOboGo_IntracellularSterolTransport',s("The","directed","movement","of","sterols","within","cells","."),4056492). assertion_content_comment('tOboGo_Intracellular',s("The","living","contents","of","a","cell",";","the","matter","contained","within","(","but","not","including",")","the","plasma","membrane",",","usually","taken","to","exclude","large","vacuoles","and","masses","of","secretory","or","ingested","material",".","In","eukaryotes","it","includes","the","nucleus","and","cytoplasm","."),3971386). assertion_content_comment('tOboGo_IntracellularTransportOfViralCapsidInHostCell',s("The","directed","movement","of","viral","capsid","proteins","within","the","host","cell","."),4099460). assertion_content_comment('tOboGo_IntracellularTransportOfViralProteinsInHostCell',s("The","directed","movement","of","viral","proteins","within","the","host","cell","."),4045651). assertion_content_comment('tOboGo_IntracellularTransport',s("The","directed","movement","of","substances","within","a","cell","."),3970099). assertion_content_comment('tOboGo_IntracellularVesiclePatternRecognitionReceptorSignalingPathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","pattern","recognition","receptor","(","PRR",")","located","within","the","membrane","of","an","intracellular","vesicle","such","as","an","endosome","or","lysosome",".","Such","receptors","bind","for","molecular","patterns","based","on","a","repeating","or","polymeric","structures",",","like","those","of","polysaccharides","or","peptidoglycans",",","which","are","sometimes","associated","with","potential","pathogens","."),4382483). assertion_content_comment('tOboGo_IntracellularVirionTransport',s("The","directed","movement","of","a","virion","within","a","host","cell","from","one","location","to","another","."),4354930). assertion_content_comment('tOboGo_IntraconoidMicrotubule',s("A","microtubule","located","such","that","it","threads","through","the","conoid","and","projects","through","the","polar","ring","."),4066406). assertion_content_comment('tOboGo_IntraflagellarAnterogradeTransport',s("The","directed","movement","of","large","protein","complexes","along","microtubules","from","the","cell","body","toward","the","tip","of","a","cilium","or","flagellum",",","mediated","by","motor","proteins","."),4380963). assertion_content_comment('tOboGo_IntraflagellarRetrogradeTransport',s("The","directed","movement","of","large","protein","complexes","along","microtubules","from","the","tip","of","a","cilium","or","flagellum","toward","the","cell","body",",","mediated","by","motor","proteins","."),4380954). assertion_content_comment('tOboGo_IntraflagellarTransportInvolvedInCiliumMorphogenesis',s("The","bidirectional","movement","of","large","protein","complexes","along","microtubules","within","a","cilium","that","contributes","to","cilium","morphogenesis","."),4082484). assertion_content_comment('tOboGo_IntraflagellarTransportInvolvedInFlagellumOrganisation',s("The","bidirectional","movement","of","large","protein","complexes","along","microtubules","within","a","flagellum","that","contributes","to","flagellum","organisation","."),4082494). assertion_content_comment('tOboGo_IntraflagellarTransportParticleA',s("The","smaller","subcomplex","of","the","intraflagellar","transport","particle",";","characterized","complexes","have","molecular","weights","of","710-760","kDa","."),4061268). assertion_content_comment('tOboGo_IntraflagellarTransportParticleB',s("The","larger","subcomplex","of","the","intraflagellar","transport","particle",";","characterized","complexes","have","molecular","weights","around","550","kDa","."),4061257). assertion_content_comment('tOboGo_IntraflagellarTransportParticle',s("A","nonmembrane-bound","oligomeric","protein","complex","that","participates","in","bidirectional","transport","of","molecules","(","cargo",")","along","axonemal","microtubules","."),4061246). assertion_content_comment('tOboGo_IntraflagellarTransport',s("The","bidirectional","movement","of","large","protein","complexes","along","microtubules","within","a","cilium","or","flagellum",",","mediated","by","motor","proteins","."),4080570). assertion_content_comment('tOboGo_IntraglomerularMesangialCellProliferation',s("The","multiplication","or","reproduction","of","intraglomerular","glomerular","mesangium","cells","by","cell","division",",","resulting","in","the","expansion","of","their","population",".","Intraglomerular","mesangial","cells","are","specialized","pericytes","located","among","the","glomerular","capillaries","within","a","renal","corpuscle","of","a","kidney",".","They","are","required","for","filtration",",","structural","support","and","phagocytosis","."),4155903). assertion_content_comment('tOboGo_IntrahepaticBileDuctDevelopment',s("The","progression","of","the","intrahepatic","bile","ducts","over","time",",","from","their","formation","to","the","mature","structure",".","Intrahepatic","bile","ducts","(","bile","ducts","within","the","liver",")","collect","bile","from","bile","canaliculi","in","the","liver",",","and","connect","to","the","extrahepatic","bile","ducts","(","bile","ducts","outside","the","liver",")"),4081923). assertion_content_comment('tOboGo_IntralumenalVesicleFormation',s("The","evagination","of","the","endosome","membrane",",","resulting","in","the","formation","of","a","vesicle","."),4177407). assertion_content_comment('tOboGo_IntramolecularLyaseActivity',s("The","catalysis","of","certain","rearrangements","of","a","molecule","to","break","or","form","a","ring","."),4205101). assertion_content_comment('tOboGo_IntramolecularOxidoreductaseActivityInterconvertingAldosesAndKetoses',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","the","hydrogen","donor","and","acceptor",",","which","is","an","aldose","or","a","ketose",",","are","the","same","molecule",",","and","no","oxidized","product","appears","."),4184807). assertion_content_comment('tOboGo_IntramolecularOxidoreductaseActivityOtherIntramolecularOxidoreductases',s("OBSOLETE",".","A","grouping","term","for","intramolecular","oxidoreductases","that","cannot","be","more","accurately","categorized","."),4301804). assertion_content_comment('tOboGo_IntramolecularOxidoreductaseActivity',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","the","hydrogen","donor","and","acceptor","are","the","same","molecule",",","and","no","oxidized","product","appears","."),4184803). assertion_content_comment('tOboGo_IntramolecularOxidoreductaseActivityTransposingCCBonds',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","the","hydrogen","donor","and","acceptor","are","the","same","molecule",",","one","or","more","carbon-carbon","double","bonds","in","the","molecule","are","rearranged",",","and","no","oxidized","product","appears","."),4201611). assertion_content_comment('tOboGo_IntramolecularTransferaseActivityPhosphotransferases',s("Catalysis","of","the","transfer","of","a","phosphate","group","from","one","position","to","another","within","a","single","molecule","."),4203183). assertion_content_comment('tOboGo_IntramolecularTransferaseActivity',s("Catalysis","of","the","transfer","of","a","functional","group","from","one","position","to","another","within","a","single","molecule","."),4182147). assertion_content_comment('tOboGo_IntramolecularTransferaseActivityTransferringAcylGroups',s("Catalysis","of","the","transfer","of","an","acyl","group","from","one","position","to","another","within","a","single","molecule","."),4271041). assertion_content_comment('tOboGo_IntramolecularTransferaseActivityTransferringAminoGroups',s("Catalysis","of","the","transfer","of","an","amino","group","from","one","position","to","another","within","a","single","molecule","."),4264675). assertion_content_comment('tOboGo_IntramolecularTransferaseActivityTransferringHydroxyGroups',s("Catalysis","of","the","transfer","of","a","hydroxyl","group","from","one","position","to","another","within","a","single","molecule","."),4248525). assertion_content_comment('tOboGo_IntramolecularTransferaseActivityTransferringOtherGroups',s("OBSOLETE",".","A","grouping","term","for","intramolecular","transferases","that","cannot","be","more","accurately","categorized","."),4301843). assertion_content_comment('tOboGo_IntraspeciesInteractionBetweenOrganisms',s("Any","process","in","which","an","organism","has","an","effect","on","an","organism","of","the","same","species","."),4029594). assertion_content_comment('tOboGo_IntraspeciesQuorumSensing',s("The","process","in","which","single-celled","organisms","of","the","same","species","monitor","population","density","by","detecting","the","concentration","of","small",",","diffusible","signal","molecules","."),4196495). assertion_content_comment('tOboGo_IntrinsicToCellOuterMembrane',s("Located","in","the","cell","outer","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4062118). assertion_content_comment('tOboGo_IntrinsicToChloroplastInnerMembrane',s("Located","in","the","chloroplast","inner","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4058741). assertion_content_comment('tOboGo_IntrinsicToChloroplastOuterMembrane',s("Located","in","the","chloroplast","outer","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4058699). assertion_content_comment('tOboGo_IntrinsicToContractileVacuolarMembrane',s("Located","in","the","contractile","vacuolar","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4059417). assertion_content_comment('tOboGo_IntrinsicToEndoplasmicReticulumMembrane',s("Located","in","the","endoplasmic","reticulum","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4062241). assertion_content_comment('tOboGo_IntrinsicToEndosomeMembrane',s("Located","in","the","endosome","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4059373). assertion_content_comment('tOboGo_IntrinsicToExternalSideOfCellOuterMembrane',s("Located","in","the","outer","membrane","of","the","cell","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane",",","with","the","bulk","of","the","gene","product","located","on","the","side","opposite","to","the","side","that","faces","the","periplasm","."),4062360). assertion_content_comment('tOboGo_IntrinsicToExternalSideOfPlasmaMembraneInPeriplasmicSpace',s("Located","in","the","plasma","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane",",","with","the","bulk","of","the","gene","product","located","in","the","periplasmic","space","."),4062207). assertion_content_comment('tOboGo_IntrinsicToExternalSideOfPlasmaMembrane',s("Located","in","the","plasma","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane",",","with","the","bulk","of","the","gene","product","located","on","the","side","opposite","to","the","side","that","faces","the","cytoplasm","."),4062149). assertion_content_comment('tOboGo_IntrinsicToGolgiMembrane',s("Located","in","the","Golgi","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4062231). assertion_content_comment('tOboGo_IntrinsicToInternalSideOfCellOuterMembrane',s("Located","in","the","outer","membrane","of","the","cell","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane",",","with","the","bulk","of","the","gene","product","located","on","the","side","that","faces","the","periplasm","."),4062409). assertion_content_comment('tOboGo_IntrinsicToInternalSideOfPlasmaMembrane',s("Located","in","the","plasma","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane",",","with","the","bulk","of","the","gene","product","located","on","the","side","that","faces","the","cytoplasm","."),4062181). assertion_content_comment('tOboGo_IntrinsicToMembrane',s("Located","in","a","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),3973157). assertion_content_comment('tOboGo_IntrinsicToMitochondrialInnerMembrane',s("Located","in","the","mitochondrial","inner","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4007604). assertion_content_comment('tOboGo_IntrinsicToMitochondrialOuterMembrane',s("Located","in","the","mitochondrial","outer","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4059395). assertion_content_comment('tOboGo_IntrinsicToNuclearInnerMembrane',s("Located","in","the","nuclear","inner","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4062263). assertion_content_comment('tOboGo_IntrinsicToNuclearOuterMembrane',s("Located","in","the","nuclear","outer","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4059384). assertion_content_comment('tOboGo_IntrinsicToOrganelleMembrane',s("Located","in","an","organelle","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4007600). assertion_content_comment('tOboGo_IntrinsicToPeroxisomalMembrane',s("Located","in","the","peroxisomal","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4062129). assertion_content_comment('tOboGo_IntrinsicToPlasmaMembrane',s("Located","in","the","plasma","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),3973206). assertion_content_comment('tOboGo_IntrinsicToPlastidInnerMembrane',s("Located","in","a","plastid","inner","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4058737). assertion_content_comment('tOboGo_IntrinsicToPlastidMembrane',s("Located","in","a","plastid","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4058692). assertion_content_comment('tOboGo_IntrinsicToPlastidOuterMembrane',s("Located","in","a","plastid","outer","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4058695). assertion_content_comment('tOboGo_IntrinsicToThylakoidMembrane',s("Located","in","a","thylakoid","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4058635). assertion_content_comment('tOboGo_IntrinsicToVacuolarMembrane',s("Located","in","the","vacuolar","membrane","such","that","some","covalently","attached","portion","of","the","gene","product",",","for","example","part","of","a","peptide","sequence","or","some","other","covalently","attached","group","such","as","a","GPI","anchor",",","spans","or","is","embedded","in","one","or","both","leaflets","of","the","membrane","."),4059413). assertion_content_comment('tOboGo_IntronHoming',s("Lateral","transfer","of","an","intron","to","a","homologous","allele","that","lacks","the","intron",",","mediated","by","a","site-specific","endonuclease","encoded","within","the","mobile","intron","."),4222370). assertion_content_comment('tOboGo_IntronicBoxCDSnoRNAProcessing',s("Any","process","involved","in","the","conversion","of","a","primary","box","C/D","type","small","nucleolar","RNA","(","snoRNA",")","transcript","that","resides","within",",","and","is","processed","from",",","the","intron","of","a","pre-mRNA","into","a","mature","box","C/D","snoRNA","."),4348660). assertion_content_comment('tOboGo_IntronicBoxHACASnoRNAProcessing',s("Any","process","involved","in","the","conversion","of","a","primary","box","H/ACA","type","small","nucleolar","RNA","(","snoRNA",")","transcript","that","resides","within",",","and","is","processed","from",",","the","intron","of","a","pre-mRNA","into","a","mature","box","H/ACA","snoRNA","."),4348640). assertion_content_comment('tOboGo_IntronicSnoRNAProcessing',s("The","biogenesis","of","a","snoRNA","molecule","which","resides","within",",","and","is","processed","from",",","the","intron","of","a","pre-mRNA","."),4319247). assertion_content_comment('tOboGo_IntronicTranscriptionRegulatoryRegionDNABinding',s("Interacting","selectively","and","non-covalently","with","an","intronic","DNA","region","that","regulates","the","transcription","of","the","transcript","it","is","contained","within","."),4288218). assertion_content_comment('tOboGo_IntronlessViralMRNAExportFromHostNucleus',s("The","directed","movement","of","intronless","viral","mRNA","from","the","host","nucleus","to","the","cytoplasm","for","translation","."),4354795). assertion_content_comment('tOboGo_IntussusceptiveAngiogenesis',s("The","formation","of","new","blood","vessels","as","a","result","of","the","insertion","and","extension","of","lumenal","tissue","pillars","."),3990880). assertion_content_comment('tOboGo_InulinaseActivity',s("Catalysis","of","the","endohydrolysis","of","2",",","1-beta-D-fructosidic","linkages","in","inulin","."),4285438). assertion_content_comment('tOboGo_InulosucraseActivity',s("Catalysis","of","the","reaction",":","sucrose","+","2",",","1-beta-D-fructosyl","(","n",")","=","glucose","+","2",",","1-beta-D-fructosyl","(","n","+","1",")"),4373600). assertion_content_comment('tOboGo_InUteroEmbryonicDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","embryo","in","the","uterus","over","time",",","from","formation","of","the","zygote","in","the","oviduct",",","to","birth",".","An","example","of","this","process","is","found","in","Mus","musculus","."),3986643). assertion_content_comment('tOboGo_InvadopodiumMembrane',s("The","portion","of","the","plasma","membrane","surrounding","an","invadopodium","."),4128553). assertion_content_comment('tOboGo_Invadopodium',s("A","cell","projection","that","emerges","from","the","ECM-facing","surface","of","a","cell",",","is","enriched","in","actin","and","associated","cytoskeletal","proteins",",","and","displays","localized","proteolytic","activity","toward","the","substrate","."),4128543). assertion_content_comment('tOboGo_InvaginationInvolvedInGastrulationWithMouthFormingSecond',s("The","infolding","of","the","epithelial","sheet","into","the","embryo","involved","in","deuterostomic","gastrulation","."),4109490). assertion_content_comment('tOboGo_InvasiveGrowthInResponseToGlucoseLimitation',s("A","growth","pattern","exhibited","by","budding","haploid","cells","under","certain","growth","conditions",",","in","which","cells","retain","the","typical","axial","budding","pattern","of","haploids",",","but","become","elongated","and","fail","to","separate","after","division",";","during","growth","on","a","solid","substrate",",","this","results","in","penetration","of","cells","into","the","agar","medium",".","An","example","of","this","process","is","found","in","Saccharomyces","cerevisiae","."),4140749). assertion_content_comment('tOboGo_InvasiveGrowthInResponseToPheromone',s("The","growth","of","colonies","in","filamentous","chains","of","cells","as","a","result","of","a","pheromone","stimulus","."),4298540). assertion_content_comment('tOboGo_InvasiveGrowth',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236102). assertion_content_comment('tOboGo_Invertasome',s("A","complex","formed","by","a","recombinase",",","a","regulatory","protein",",","and","the","DNA","sequences","bound","by","each","protein",";","catalyzes","a","reversible","site-specific","recombination","reaction","that","results","in","the","alternate","expression","of","one","or","more","genes","in","various","contexts","."),4319429). assertion_content_comment('tOboGo_InvestmentCone',s("A","cytoskeletal","part","that","consists","of","a","microfilament-rich","cone","that","forms","round","each","nucleus","in","a","spermatogenic","cyst","and","translocates","the","length","of","the","cyst","during","sperm","individualization","."),4132260). assertion_content_comment('tOboGo_InvoluntarySkeletalMuscleContraction',s("A","process","in","which","force","is","generated","within","involuntary","skeletal","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","Involuntary","skeletal","muscle","is","skeletal","muscle","that","is","not","under","conscious","control","."),4193905). assertion_content_comment('tOboGo_InvolutionInvolvedInGastrulationWithMouthFormingSecond',s("The","inturning","of","an","epithelial","sheet","over","the","basal","surface","of","an","outer","layer","involved","in","deuterostomic","gastrulation","."),4109501). assertion_content_comment('tOboGo_InwardMigrationOfDeepNuclearNeurons',s("The","directed","movement","of","a","deep","nuclear","neuron","from","the","rostrodorsal","region","of","the","cerebellar","plate","to","their","final","more","ventral","position","."),4047995). assertion_content_comment('tOboGo_InwardRectifierChannel',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4217988). assertion_content_comment('tOboGo_InwardRectifierPotassiumChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","potassium","ion","by","an","inwardly-rectifying","voltage-gated","channel",".","An","inwardly","rectifying","current-voltage","relation","is","one","where","at","any","given","driving","force","the","inward","flow","of","K","+","ions","exceeds","the","outward","flow","for","the","opposite","driving","force",".","The","inward-rectification","is","due","to","a","voltage-dependent","block","of","the","channel","pore","by","a","specific","ligand","or","ligands",",","and","as","a","result","the","macroscopic","conductance","depends","on","the","difference","between","membrane","voltage","and","the","K","+","equilibrium","potential","rather","than","on","membrane","voltage","itself","."),4217984). assertion_content_comment('tOboGo_InwardRectifierPotassiumChannelInhibitorActivity',s("Stops",",","prevents",",","or","reduces","the","activity","of","an","inwardly","rectifying","potassium","channel","."),4173078). assertion_content_comment('tOboGo_IodideOxidation',s("The","chemical","reactions","and","pathways","by","which","iodide","is","converted","to","diiodine",",","with","the","concomitant","loss","of","electrons","."),4174230). assertion_content_comment('tOboGo_IodidePeroxidaseActivity',s("Catalysis","of","the","reaction",":","iodide","+","hydrogen","peroxide","=","iodine","+","2","H2O","."),4207032). assertion_content_comment('tOboGo_IodideTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","iodide","ions","from","one","side","of","a","membrane","to","the","other","."),4297376). assertion_content_comment('tOboGo_IodideTransport',s("The","directed","movement","of","iodide","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290682). assertion_content_comment('tOboGo_IonBinding',s("Interacting","selectively","and","non-covalently","with","ions",",","charged","atoms","or","groups","of","atoms","."),4079816). assertion_content_comment('tOboGo_IonChannelActivity',s("Catalysis","of","facilitated","diffusion","of","an","ion","(","by","an","energy-independent","process",")","by","passage","through","a","transmembrane","aqueous","pore","or","channel","without","evidence","for","a","carrier-mediated","mechanism","."),4158373). assertion_content_comment('tOboGo_IonChannelBinding',s("Interacting","selectively","and","non-covalently","with","one","or","more","specific","sites","on","an","ion","channel",",","a","protein","complex","that","spans","a","membrane","and","forms","a","water-filled","channel","across","the","phospholipid","bilayer","allowing","selective","ion","transport","down","its","electrochemical","gradient","."),4287810). assertion_content_comment('tOboGo_IonChannelComplex',s("A","protein","complex","that","spans","a","membrane","and","forms","a","water-filled","channel","across","the","phospholipid","bilayer","allowing","selective","ion","transport","down","its","electrochemical","gradient","."),3981966). assertion_content_comment('tOboGo_IonChannelInhibitorActivity',s("Stops",",","prevents",",","or","reduces","the","activity","of","an","ion","channel","."),4173064). assertion_content_comment('tOboGo_IonGatedChannelActivity',s("Catalysis","of","the","transmembrane","transfer","of","a","solute","by","a","channel","that","opens","in","response","to","a","specific","ion","stimulus","."),4159417). assertion_content_comment('tOboGo_IonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","ions","within","an","organism","or","cell","."),4003069). assertion_content_comment('tOboGo_IonotropicGlutamateReceptorActivity',s("Combining","with","glutamate","to","initiate","a","change","in","cell","activity","through","the","regulation","of","ion","channels","."),4198033). assertion_content_comment('tOboGo_IonotropicGlutamateReceptorBinding',s("Interacting","selectively","and","non-covalently","with","an","ionotropic","glutamate","receptor",".","Ionotropic","glutamate","receptors","bind","glutamate","and","exert","an","effect","through","the","regulation","of","ion","channels","."),4382700). assertion_content_comment('tOboGo_IonotropicGlutamateReceptorComplex',s("A","multimeric","assembly","of","four","or","five","subunits","which","form","a","structure","with","an","extracellular","N-terminus","and","a","large","loop","that","together","form","the","ligand","binding","domain",".","The","C-terminus","is","intracellular",".","The","ionotropic","glutamate","receptor","complex","itself","acts","as","a","ligand-gated","ion","channel",";","on","binding","glutamate",",","charged","ions","pass","through","a","channel","in","the","center","of","the","receptor","complex","."),4020718). assertion_content_comment('tOboGo_IonotropicGlutamateReceptorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","glutamate","binding","to","a","cell","surface","receptor",",","followed","by","the","movement","of","ions","through","a","channel","in","the","receptor","complex","."),4382620). assertion_content_comment('tOboGo_IonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","an","ion","from","one","side","of","a","membrane","to","the","other","."),4020448). assertion_content_comment('tOboGo_IonTransmembraneTransport',s("A","process","in","which","an","ion","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4073237). assertion_content_comment('tOboGo_IonTransport',s("The","directed","movement","of","charged","atoms","or","small","charged","molecules","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3990528). assertion_content_comment('tOboGo_IPAFInflammasomeComplex',s("A","protein","complex","that","consists","of","four","components",",","NALP1",",","PYCARD","(","ASC",")","(","27",")",",","caspase-1","and","caspase-5",",","and","includes","among","its","functions","that","of","being","the","primary","mediator","of","susceptibility","to","anthrax","lethal","toxin","."),4157850). assertion_content_comment('tOboGo_IprodioneAmidohydrolaseActivity',s("Catalysis","of","the","reaction",":","iprodione","+","OH-","=","3",",","5-dichlorophenylcarboximide","+","N-isopropylcarbamate","."),4274949). assertion_content_comment('tOboGo_IprodioneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","prodione",",","a","colorless",",","odorless","crystal",".","It","is","used","as","a","dicarboximide","contact","fungicide","to","control","a","wide","variety","of","crop","diseases","by","inhibiting","the","germination","of","spores","and","the","growth","of","the","fungal","mat","(","mycelium",")"),4272089). assertion_content_comment('tOboGo_IridophoreDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","an","iridophore",".","Iridophores","are","pigment","cells","derived","from","the","neural","crest",".","They","contain","guanidine","or","other","purine","crystals","deposited","in","stacks","called","reflecting","platets","or","iridisomes",".","This","gives","them","a","silver",",","gold",",","or","iridescent","appearance","."),4099966). assertion_content_comment('tOboGo_Iridosome',s("A","tissue-specific",",","membrane-bounded","cytoplasmic","organelle","within","which","purines","crystalize","in","reflective","stacks",".","Iridosomes","are","synthesized","in","iridophore","cells","and","are","silver",",","gold","or","iridescent","in","appearance","."),4326411). assertion_content_comment('tOboGo_IrisMorphogenesis',s("The","process","in","which","the","iris","is","generated","and","organized",".","The","iris","is","an","anatomical","structure","in","the","eye","whose","opening","forms","the","pupil",".","The","iris","is","responsible","for","controlling","the","diameter","and","size","of","the","pupil","and","the","amount","of","light","reaching","the","retina","."),4113589). assertion_content_comment('tOboGo_IronAssimilationByCaptureAndTransport',s("A","process","in","which","iron","(","Fe3","+",")","is","solubilized","by","binding","to","a","receptor","or","transport","protein","and","transported","into","a","cell","."),4338045). assertion_content_comment('tOboGo_IronAssimilationByChelationAndTransport',s("A","process","in","which","iron","(","Fe3","+",")","is","solubilized","by","ferric","iron-specific","chelators",",","known","as","siderophores",",","excreted","by","a","cell",";","the","iron-siderophore","complex","is","then","transported","into","the","cell","by","specific","cell","surface","receptors","."),4033965). assertion_content_comment('tOboGo_IronAssimilationByReductionAndTransport',s("A","process","in","which","iron","is","solubilized","by","reduction","from","Fe3","+","to","Fe2","+","via","a","cell","surface","reductase","and","subsequent","transport","of","the","iron","across","the","membrane","by","iron","uptake","proteins","."),4338054). assertion_content_comment('tOboGo_IronAssimilation',s("A","process","in","which","iron","is","solubilized","and","transported","into","a","cell","."),4011670). assertion_content_comment('tOboGo_IronChaperoneActivity',s("Assists","in","the","delivery","of","iron","ions","to","target","proteins","or","compartments","."),4348518). assertion_content_comment('tOboGo_IronChelateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","an","iron","chelate","from","one","side","of","a","membrane","to","the","other",".","An","iron","chelate","is","a","heterocyclic","compound","having","a","metal","ion","attached","by","coordinate","bonds","to","at","least","two","nonmetal","ions","."),4183848). assertion_content_comment('tOboGo_IronChelateTransport',s("The","directed","movement","of","iron","chelates","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","An","iron","chelate","is","a","heterocyclic","compound","having","a","metal","ion","attached","by","coordinate","bonds","to","at","least","two","nonmetal","ions","."),4033997). assertion_content_comment('tOboGo_IronIonBinding',s("Interacting","selectively","and","non-covalently","with","iron","(","Fe",")","ions","."),4079827). assertion_content_comment('tOboGo_IronIonHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","iron","ions","within","an","organism","or","cell","."),4011664). assertion_content_comment('tOboGo_IronIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","iron","(","Fe",")","ions","from","one","side","of","a","membrane","to","the","other","."),4183841). assertion_content_comment('tOboGo_IronIonTransmembraneTransport',s("A","process","in","which","an","iron","ion","is","transported","from","one","side","of","a","membrane","to","the","other","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4073325). assertion_content_comment('tOboGo_IronIonTransport',s("The","directed","movement","of","iron","(","Fe",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4033994). assertion_content_comment('tOboGo_IrritableAggressiveBehavior',s("Aggressive","behavior","induced","by","frustration","and","directed","against","an","available","target","."),4375557). assertion_content_comment('tOboGo_IsethionateChannelActivity',"OBSOLETE.",4295389). assertion_content_comment('tOboGo_ISG15ActivatingEnzymeActivity',s("Catalysis","of","the","activation","of","the","small","ubiquitin-related","modifier","ISG15",",","through","the","formation","of","an","ATP-dependent","high-energy","thiolester","bond","."),4245406). assertion_content_comment('tOboGo_ISG15CarrierActivity',s("Catalysis","of","the","transfer","of","ISG15","(","interferon-stimulated","gene-15",")","from","one","side","of","the","membrane","to","the","other","."),4234262). assertion_content_comment('tOboGo_ISG15LigaseActivity',s("Catalysis","of","the","covalent","attachment","of","the","ubiquitin-like","protein","ISG15","to","other","proteins","."),4314084). assertion_content_comment('tOboGo_ISGF3Complex',s("A","transcription","factor","complex","that","consists","of","a","Stat1-Stat2","heterodimer","and","the","IRF9","protein","."),4176602). assertion_content_comment('tOboGo_IsletAmyloidPolypeptideProcessing',s("The","formation","of","mature","islet","amyloid","polypeptide","(","IAPP",")","by","posttranslational","processing","of","pro-islet","amyloid","polypeptide","(","pro-IAPP",")"),4359669). assertion_content_comment('tOboGo_IsoamylaseActivity',s("Catalysis","of","the","hydrolysis","of","alpha-","(","1",",","6",")","-D-glucosidic","branch","linkages","in","glycogen",",","amylopectin","and","their","beta-limits","dextrins","."),4237624). assertion_content_comment('tOboGo_IsoamylaseComplex',s("A","protein","complex","whose","composition","varies","amongst","species",";","in","rice","it","probably","exists","in","a","homo-tetramer","to","homo-hexamer","form","and","in","Gram-negative","bacteria","as","a","dimer",".","Functions","in","the","hydrolysis","of","alpha-","(","1",",","6",")","-D-glucosidic","branch","linkages","."),4221248). assertion_content_comment('tOboGo_IsochorismataseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","isochorismate","=","2",",","3-dihydroxy-2",",","3-dihydrobenzoate","+","pyruvate","."),4248540). assertion_content_comment('tOboGo_IsochorismatePyruvateLyaseActivity',s("Catalysis","of","the","reaction",":","isochorismate","=","salicylate","+","pyruvate","."),4328674). assertion_content_comment('tOboGo_IsochorismateSynthaseActivity',s("Catalysis","of","the","reaction",":","chorismate","=","isochorismate","."),4248527). assertion_content_comment('tOboGo_IsocitrateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","isocitrate","+","acceptor","=","2-oxoglutarate","+","CO2","+","reduced","acceptor","."),4206864). assertion_content_comment('tOboGo_IsocitrateDehydrogenaseComplexNAD',s("Complex","that","possesses","isocitrate","dehydrogenase","(","NAD","+",")","activity","."),4221058). assertion_content_comment('tOboGo_IsocitrateDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","isocitrate","+","NAD","+","=","2-oxoglutarate","+","CO2","+","NADH","+","H","+"),4207053). assertion_content_comment('tOboGo_IsocitrateDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","isocitrate","+","NADP","+","=","2-oxoglutarate","+","CO2","+","NADPH","+","H","+"),4206877). assertion_content_comment('tOboGo_IsocitrateDehydrogenaseNADPKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","(","isocitrate","dehydrogenase","(","NADP",")",")","=","ADP","+","(","isocitrate","dehydrogenase","(","NADP",")",")","phosphate","."),4251821). assertion_content_comment('tOboGo_IsocitrateEpimeraseActivity',s("Catalysis","of","the","reaction",":","D-threo-isocitrate","=","D-erythro-isocitrate","."),4373209). assertion_content_comment('tOboGo_IsocitrateLyaseActivity',s("Catalysis","of","the","reaction",":","isocitrate","=","glyoxylate","+","succinate","."),4206902). assertion_content_comment('tOboGo_IsocitrateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","isocitrate",",","the","anion","of","isocitric","acid",",","1-hydroxy-1",",","2",",","3-propanetricarboxylic","acid",".","Isocitrate","is","an","important","intermediate","in","the","TCA","cycle","and","the","glycoxylate","cycle","."),4224501). assertion_content_comment('tOboGo_IsoflavonoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","isoflavonoids",",","a","group","of","water-soluble","phenolic","derivatives",",","isomeric","with","flavonoids","."),4260607). assertion_content_comment('tOboGo_IsoflavonoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","isoflavonoids",",","a","group","of","water-soluble","phenolic","derivatives",",","isomeric","with","flavonoids","."),4353003). assertion_content_comment('tOboGo_IsoflavonoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","isoflavonoids",",","a","group","of","water-soluble","phenolic","derivatives",",","isomeric","with","flavonoids",",","containing","a","flavan","skeleton",".","They","are","differentiated","from","flavonoids","by","the","point","of","attachment","of","the","aromatic","ring","group","."),4260604). assertion_content_comment('tOboGo_IsoflavonoidPhytoalexinBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","isoflavonoid","phytoalexins",",","a","group","of","water-soluble","phenolic","derivatives","isomeric","with","flavonoids","that","possess","antibiotic","activity","and","are","produced","by","plant","tissues","in","response","to","infection","."),4260745). assertion_content_comment('tOboGo_IsoflavonoidPhytoalexinCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","isoflavonoid","phytoalexins",",","a","group","of","water-soluble","phenolic","derivatives","isomeric","with","flavonoids","that","possess","antibiotic","activity","and","are","produced","by","plant","tissues","in","response","to","infection","."),4353037). assertion_content_comment('tOboGo_IsoflavonoidPhytoalexinMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","isoflavonoid","phytoalexins",",","a","group","of","water-soluble","phenolic","derivatives","isomeric","with","flavonoids","that","possess","antibiotic","activity","and","are","produced","by","plant","tissues","in","response","to","infection","."),4260741). assertion_content_comment('tOboGo_IsoleucineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","isoleucine",",","(","2R","*",",","3R","*",")","-2-amino-3-methylpentanoic","acid","."),4257188). assertion_content_comment('tOboGo_IsoleucineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","isoleucine",",","(","2R","*",",","3R","*",")","-2-amino-3-methylpentanoic","acid","."),4231569). assertion_content_comment('tOboGo_IsoleucineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","isoleucine",",","(","2R","*",",","3R","*",")","-2-amino-3-methylpentanoic","acid","."),4231437). assertion_content_comment('tOboGo_IsoleucineTransport',s("The","directed","movement","of","isoleucine",",","(","2R","*",",","3R","*",")","-2-amino-3-methylpentanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293825). assertion_content_comment('tOboGo_IsoleucineValine_SodiumSymporterActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","(","isoleucine","or","valine",")","(","out",")","+","Na","+","(","out",")","=","(","isoleucine","or","valine",")","(","in",")","+","Na","+","(","in",")"),4346336). assertion_content_comment('tOboGo_IsomaltuloseSynthaseActivity',s("Catalysis","of","the","reaction",":","sucrose","=","6-O-alpha-D-glucopyranosyl-D-fructofuranose","."),4270463). assertion_content_comment('tOboGo_IsomeraseActivity',s("Catalysis","of","the","geometric","or","structural","changes","within","one","molecule",".","Isomerase","is","the","systematic","name","for","any","enzyme","of","EC","class","5","."),4174307). assertion_content_comment('tOboGo_IsonicotinateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","isonicotinate","+","acceptor","+","H2O","=","2-hydroxyisonicotinate","+","reduced","acceptor","."),4351046). assertion_content_comment('tOboGo_IsonicotinateReductaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","isonicotinate","+","2","H","+","+","2","e-","=","1",",","4-dihydroisonicotinate","."),4351066). assertion_content_comment('tOboGo_IsonicotinicAcidHydrazideHydrolaseActivity',s("Catalysis","of","the","reaction",":","isoniazid","+","H2O","=","isonicotinate","+","hydrazine","."),4350992). assertion_content_comment('tOboGo_IsonocardicinSynthaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","+","nocardicin","E","=","S-methyl-5","'","-thioadenosine","+","H","(","+",")","+","isonocardicin","A","."),4270476). assertion_content_comment('tOboGo_IsooctaneMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","isooctane","+","1/2","O2","=","2",",","4",",","4-trimethyl-1-pentanol","."),4350784). assertion_content_comment('tOboGo_IsopentenylAdenineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","cytokinin","6-isopentenyladenine","."),4360170). assertion_content_comment('tOboGo_IsopentenylAdenineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","cytokinin","6-isopentenyladenine","."),4360186). assertion_content_comment('tOboGo_IsopentenylAdenineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","the","cytokinin","6-isopentenyladenine","."),4360157). assertion_content_comment('tOboGo_IsopentenylDiphosphateBiosyntheticProcessMevalonatePathwayInvolvedInTerpenoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","isopentenyl","diphosphate","by","the","mevalonate","pathway","that","contributes","to","terpenoid","biosynthesis",".","This","pathway","converts","acetate",",","in","the","form","of","acetyl-CoA",",","to","isopentenyl","diphosphate","(","IPP",")","through","a","series","of","mevalonate","intermediates","."),4118933). assertion_content_comment('tOboGo_IsopentenylDiphosphateBiosyntheticProcessMevalonatePathway',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","isopentenyl","diphosphate",",","via","the","intermediate","mevalonate",".","This","pathway","converts","acetate",",","in","the","form","of","acetyl-CoA",",","to","isopentenyl","diphosphate","(","IPP",")",",","the","fundamental","unit","in","isoprenoid","biosynthesis",",","through","a","series","of","mevalonate","intermediates","."),4118925). assertion_content_comment('tOboGo_IsopentenylDiphosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","isopentenyl","diphosphate",",","an","isomer","of","dimethylallyl","diphosphate","and","the","key","precursor","of","all","isoprenoids","."),4023893). assertion_content_comment('tOboGo_IsopentenylDiphosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","isopentenyl","diphosphate",",","an","isomer","of","dimethylallyl","diphosphate","and","the","key","precursor","of","all","isoprenoids","."),4023885). assertion_content_comment('tOboGo_IsopeptidaseActivity',s("Catalysis","of","the","hydrolysis","of","an","isopeptide","bond",".","An","isopeptide","bond","is","an","amide","linkage","between","a","carboxyl","group","of","one","amino","acid","and","an","amino","group","of","another","amino","acid","in","which","at","least","one","of","these","groups","is","not","on","the","a-carbon","of","one","of","the","amino","acids","(","for","example",",","the","link","between","an","epsilon-amino","group","of","a","lysine","molecule","to","a","carboxyl","group","on","a","second","amino","acid","is","an","isopeptide","bond",")"),4179585). assertion_content_comment('tOboGo_IsopiperitenolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","1S",",","6R",")","-isopiperitenol","+","NAD","(","+",")","=","(","6R",")","-isoperitenone","+","H","(","+",")","+","NADH","."),4281776). assertion_content_comment('tOboGo_IsopreneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","isoprene",",","C5H8","."),4325344). assertion_content_comment('tOboGo_IsopreneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","isoprene",",","C5H8","."),4325369). assertion_content_comment('tOboGo_IsopreneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","isoprene",",","C5H8","."),4325337). assertion_content_comment('tOboGo_IsopreneSynthaseActivity',s("Catalysis","of","the","reaction",":","dimethylallyl","diphosphate","=","diphosphate","+","isoprene","."),4360742). assertion_content_comment('tOboGo_IsoprenoidBinding',s("Interacting","selectively","and","non-covalently","with","any","isoprenoid","compound",",","isoprene","(","2-methylbuta-1",",","3-diene",")","or","compounds","containing","or","derived","from","linked","isoprene","(","3-methyl-2-butenylene",")","residues","."),4219033). assertion_content_comment('tOboGo_IsoprenoidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","isoprenoid","compound",",","isoprene","(","2-methylbuta-1",",","3-diene",")","or","compounds","containing","or","derived","from","linked","isoprene","(","3-methyl-2-butenylene",")","residues","."),4010001). assertion_content_comment('tOboGo_IsoprenoidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","isoprenoid","compound",",","isoprene","(","2-methylbuta-1",",","3-diene",")","or","compounds","containing","or","derived","from","linked","isoprene","(","3-methyl-2-butenylene",")","residues","."),4092348). assertion_content_comment('tOboGo_IsoprenoidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","isoprenoid","compounds",",","isoprene","(","2-methylbuta-1",",","3-diene",")","or","compounds","containing","or","derived","from","linked","isoprene","(","3-methyl-2-butenylene",")","residues","."),4009992). assertion_content_comment('tOboGo_IsoprenoidTransport',s("The","directed","movement","of","isoprenoids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Isoprenoids","comprise","a","group","of","compounds","containing","or","derived","from","linked","isoprene","(","3-methyl-2-butenylene",")","residues","."),4168013). assertion_content_comment('tOboGo_IsopropanolDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","propan-2-ol","=","acetone","+","H","(","+",")","+","NADPH","."),4270453). assertion_content_comment('tOboGo_IsopropylmalateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","isopropylmalate","from","one","side","of","the","membrane","to","the","other","."),4354434). assertion_content_comment('tOboGo_IsopropylmalateTransport',s("The","directed","movement","of","isopropylmalate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4354443). assertion_content_comment('tOboGo_IsoproturonDimethylaminedehydrogenaseActivity',s("Catalysis","of","the","reaction",":","isoproturon","+","H2O","=","formaldehyde","+","monodemethylisoproturon","+","2","H","+","+","2","e-","."),4352588). assertion_content_comment('tOboGo_IsopullulanaseActivity',s("Catalysis","of","the","hydrolysis","of","pullulan","to","isopanose","(","6-alpha-maltosylglucose",")"),4285525). assertion_content_comment('tOboGo_IsoquinolineAlkaloidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","isoquinoline","alkaloids",",","alkaloid","compounds","that","contain","bicyclic","N-containing","aromatic","rings","and","are","derived","from","a","3",",","4-dihydroxytyramine","(","dopamine",")","precursor","that","undergoes","a","Schiff","base","addition","with","aldehydes","of","different","origin","."),4260790). assertion_content_comment('tOboGo_IsoquinolineAlkaloidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","isoquinoline","alkaloids",",","alkaloid","compounds","that","contain","bicyclic","N-containing","aromatic","rings","and","are","derived","from","a","3",",","4-dihydroxytyramine","(","dopamine",")","precursor","that","undergoes","a","Schiff","base","addition","with","aldehydes","of","different","origin","."),4166674). assertion_content_comment('tOboGo_IsoquinolineAlkaloidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","isoquinoline","alkaloids",",","alkaloid","compounds","that","contain","bicyclic","N-containing","aromatic","rings","and","are","derived","from","a","3",",","4-dihydroxytyramine","(","dopamine",")","precursor","that","undergoes","a","Schiff","base","addition","with","aldehydes","of","different","origin","."),4166670). assertion_content_comment('tOboGo_IsotropicCellGrowth',s("The","process","in","which","a","cell","irreversibly","increases","in","size","uniformly","in","all","directions",".","In","general",",","a","rounded","cell","morphology","reflects","isotropic","cell","growth","."),4287543). assertion_content_comment('tOboGo_IsotypeSwitching',s("The","switching","of","activated","B","cells","from","IgM","biosynthesis","to","biosynthesis","of","other","isotypes","of","immunoglobulin",",","accomplished","through","a","recombination","process","involving","an","intrachromosomal","deletion","involving","switch","regions","that","reside","5","'","of","each","constant","region","gene","segment","in","the","immunoglobulin","heavy","chain","locus","."),4086073). assertion_content_comment('tOboGo_IsotypeSwitchingToIgAIsotypes',s("The","switching","of","activated","B","cells","from","IgM","biosynthesis","to","biosynthesis","of","an","IgA","isotype",",","accomplished","through","a","recombination","process","involving","an","intrachromosomal","deletion","between","switch","regions","that","reside","5","'","of","the","IgM","and","one","of","the","IgA","constant","region","gene","segments","in","the","immunoglobulin","heavy","chain","locus","."),4103821). assertion_content_comment('tOboGo_IsotypeSwitchingToIgDIsotypes',s("The","switching","of","activated","B","cells","from","IgM","biosynthesis","to","IgD","biosynthesis",",","accomplished","through","a","recombination","process","involving","an","intrachromosomal","deletion","between","switch","regions","that","reside","5","'","of","the","IgM","and","IgD","constant","region","gene","segments","in","the","immunoglobulin","heavy","chain","locus","."),4103581). assertion_content_comment('tOboGo_IsotypeSwitchingToIgEIsotypes',s("The","switching","of","activated","B","cells","from","IgM","biosynthesis","to","IgE","biosynthesis",",","accomplished","through","a","recombination","process","involving","an","intrachromosomal","deletion","between","switch","regions","that","reside","5","'","of","the","IgM","and","IgE","constant","region","gene","segments","in","the","immunoglobulin","heavy","chain","locus","."),4103778). assertion_content_comment('tOboGo_IsotypeSwitchingToIgGIsotypes',s("The","switching","of","activated","B","cells","from","IgM","biosynthesis","to","biosynthesis","of","an","IgG","isotype",",","accomplished","through","a","recombination","process","involving","an","intrachromosomal","deletion","between","switch","regions","that","reside","5","'","of","the","IgM","and","one","of","the","IgG","constant","region","gene","segments","in","the","immunoglobulin","heavy","chain","locus","."),4103642). assertion_content_comment('tOboGo_ISW1Complex',s("A","protein","complex","that","contains","an","ISWI-family","ATPase","such","as","Saccharomyces","Isw1p",",","and","acts","to","modify","chromatin","structure","."),4305596). assertion_content_comment('tOboGo_ISWIComplex',s("Any","chromatin","remodeling","complex","that","contains","an","ATPase","subunit","of","the","ISWI","family","."),4305594). assertion_content_comment('tOboGo_ITPBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ITP",",","inosine","triphosphate","."),4348393). assertion_content_comment('tOboGo_ITPCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ITP",",","inosine","(","5","'","-",")","triphosphate","."),4227450). assertion_content_comment('tOboGo_ITPMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ITP",",","inosine","triphosphate","."),4227447). assertion_content_comment('tOboGo_JAKPathwaySignalTransductionAdaptorActivity',s("The","binding","activity","of","a","molecule","that","brings","together","two","molecules","of","the","JAK","signal","transduction","pathway",",","permitting","them","to","function","in","a","coordinated","way","."),4256157). assertion_content_comment('tOboGo_JasmonicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","jasmonic","acid",",","a","fatty","acid","derivative","."),4147806). assertion_content_comment('tOboGo_JasmonicAcidMediatedSignalingPathway',s("A","series","of","molecular","signals","mediated","by","jasmonic","acid","."),4022013). assertion_content_comment('tOboGo_JasmonicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","jasmonic","acid",",","a","fatty","acid","derivative","with","the","formula","(","1R-","(","1","alpha",",","2","beta","(","Z",")",")",")","-3-oxo-2-","(","2-pentenyl",")","cyclopentaneacetic","acid","."),4147788). assertion_content_comment('tOboGo_JNKCascade',s("A","cascade","of","protein","kinase","activities",",","culminating","in","the","phosphorylation","and","activation","of","a","member","of","the","JUN","kinase","subfamily","of","stress-activated","protein","kinases",",","which","in","turn","are","a","subfamily","of","mitogen-activated","protein","(","MAP",")","kinases","that","is","activated","primarily","by","cytokines","and","exposure","to","environmental","stress","."),4016524). assertion_content_comment('tOboGo_JumpResponse',s("The","sudden",",","usually","upward",",","movement","off","the","ground","or","other","surface","through","sudden","muscular","effort","in","the","legs",",","following","exposure","to","an","external","stimulus","."),4235037). assertion_content_comment('tOboGo_JunctionalMembraneComplex',s("Complex","formed","in","muscle","cells","between","the","membrane","of","the","sarcoplasmic","reticulum","and","invaginations","of","the","plasma","membrane","(","T-tubules",")"),4048017). assertion_content_comment('tOboGo_JunctionalSarcoplasmicReticulumMembrane',s("The","part","of","the","sarcoplasmic","reticulum","membrane","that","contains","calcium","release","channels",",","is","devoted","to","calcium","release","and","is","juxtaposed","to","transverse","tubule","membrane",".","The","junctional","sarcoplasmic","reticulum","membrane","consists","of","the","junctional","region","of","the","terminal","cisterna","membrane","."),4320734). assertion_content_comment('tOboGo_JUNKinaseActivity',s("Catalysis","of","the","reaction",":","JUN","+","ATP","=","JUN","phosphate","+","ADP",".","This","reaction","is","the","phosphorylation","and","activation","of","members","of","the","JUN","family",",","a","gene","family","that","encodes","nuclear","transcription","factors","."),4200699). assertion_content_comment('tOboGo_JUNKinaseBinding',s("Interacting","selectively","and","non-covalently","with","JUN","kinase",",","an","enzyme","that","catalyzes","the","phosphorylation","and","activation","of","members","of","the","JUN","family","."),4253622). assertion_content_comment('tOboGo_JUNKinaseKinaseActivity',s("Catalysis","of","the","phosphorylation","of","tyrosine","and","threonine","residues","in","a","c-Jun","NH2-terminal","kinase","(","JNK",")",",","a","member","of","a","subgroup","of","mitogen-activated","protein","kinases","(","MAPKs",")",",","which","signal","in","response","to","cytokines","and","exposure","to","environmental","stress",".","JUN","kinase","kinase","(","JNKK",")","is","a","dual-specificity","protein","kinase","kinase","and","requires","activation","by","a","serine/threonine","kinase","JUN","kinase","kinase","kinase","."),4252688). assertion_content_comment('tOboGo_JUNKinaseKinaseKinaseActivity',s("Catalysis","of","the","reaction",":","JNKK","+","ATP","=","JNKK","phosphate","+","ADP",".","This","reaction","is","the","phosphorylation","and","activation","of","JUN","kinase","kinases","(","JNKKs",")"),4200623). assertion_content_comment('tOboGo_JUNKinaseKinaseKinaseKinaseActivity',s("Catalysis","of","the","phosphorylation","and","activation","of","JUN","kinase","kinase","kinases","(","JNKKKs",")"),4316577). assertion_content_comment('tOboGo_JUNKinasePhosphataseActivity',s("Catalysis","of","the","reaction",":","JUN","kinase","serine/threonine/tyrosine","phosphate","+","H2O","=","JUN","kinase","serine/threonine/tyrosine","+","phosphate","."),4252533). assertion_content_comment('tOboGo_JUNPhosphorylation',s("The","process","of","introducing","a","phosphate","group","into","a","JUN","protein","."),4016641). assertion_content_comment('tOboGo_JuvenileHormoneAcidMethyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","juvenile","hormone","acid","."),4381745). assertion_content_comment('tOboGo_JuvenileHormoneBinding',s("Interacting","selectively","and","non-covalently","with","juvenile","hormone",",","the","three","sesquiterpenoid","derivatives","that","function","to","maintain","the","larval","state","of","insects","at","molting","and","that","may","be","required","for","other","processes",",","e.g",".","oogenesis","."),4219077). assertion_content_comment('tOboGo_JuvenileHormoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","juvenile","hormones",",","the","three","sesquiterpenoid","derivatives","that","function","to","maintain","the","larval","state","of","insects","at","molting","and","that","may","be","required","for","other","processes",",","e.g",".","oogenesis","."),4015603). assertion_content_comment('tOboGo_JuvenileHormoneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","juvenile","hormones",",","the","three","sesquiterpenoid","derivatives","that","function","to","maintain","the","larval","state","of","insects","at","molting","and","that","may","be","required","for","other","processes",",","e.g",".","oogenesis","."),4092396). assertion_content_comment('tOboGo_JuvenileHormoneEpoxideHydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","the","epoxide","in","a","juvenile","hormone","to","the","corresponding","diol","."),4247084). assertion_content_comment('tOboGo_JuvenileHormoneMediatedSignalingPathway',s("A","series","of","molecular","signals","initiated","by","the","binding","of","juvenile","hormone","to","a","receptor",",","and","ending","with","regulation","of","cell","state","or","activity","."),4380045). assertion_content_comment('tOboGo_JuvenileHormoneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","juvenile","hormones",",","the","three","sesquiterpenoid","derivatives","that","function","to","maintain","the","larval","state","of","insects","at","molting","and","that","may","be","required","for","other","processes",",","e.g",".","oogenesis","."),4015526). assertion_content_comment('tOboGo_JuvenileHormoneReceptorActivity',s("Combining","with","juvenile","hormone","to","initiate","a","change","in","cell","activity","."),4200093). assertion_content_comment('tOboGo_JuvenileHormoneResponseElementBinding',s("Interacting","selectively","and","non-covalently","with","the","juvenile","hormone","response","element","(","JHRE",")",",","a","conserved","sequence","found","in","the","promoters","of","genes","whose","expression","is","regulated","in","response","to","juvenile","hormone","."),4175261). assertion_content_comment('tOboGo_JuvenileHormoneSecretion',s("The","regulated","release","of","juvenile","hormones",",","the","three","sesquiterpenoid","derivatives","that","function","to","maintain","the","larval","state","of","insects","at","molting","and","that","may","be","required","for","other","processes",",","e.g",".","oogenesis","."),4015385). assertion_content_comment('tOboGo_JuxtaglomerularApparatusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","juxtaglomerular","apparatus","over","time",",","from","its","formation","to","the","mature","structure",".","The","juxtaglomerular","apparatus","is","an","anatomical","structure","that","lies","adjacent","to","the","glomerulus","and","regulates","kidney","function","."),4122897). assertion_content_comment('tOboGo_JuxtaglomerulusCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","juxtaglomerulus","cell","over","time",",","from","its","formation","to","the","mature","structure","."),4122909). assertion_content_comment('tOboGo_JuxtaglomerulusCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","that","characterize","the","juxtaglomerulus","cells","of","the","kidney","as","it","progresses","from","its","formation","to","the","mature","state","."),4122899). assertion_content_comment('tOboGo_JuxtaglomerulusCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","juxtaglomerulus","cell","."),4123146). assertion_content_comment('tOboGo_JuxtaparanodeRegionOfAxon',s("A","region","of","an","axon","near","a","node","of","Ranvier","that","is","between","the","paranode","and","internode","regions","."),4097990). assertion_content_comment('tOboGo_KainateSelectiveGlutamateReceptorActivity',s("An","ionotropic","glutamate","receptor","activity","that","exhibits","fast","gating","by","glutamate",",","acts","by","opening","a","cation","channel","permeable","to","sodium","and","potassium",",","and","for","which","kainate","is","an","agonist","."),4295220). assertion_content_comment('tOboGo_KainateSelectiveGlutamateReceptorComplex',s("An","assembly","of","four","or","five","subunits","which","form","a","structure","with","an","extracellular","N-terminus","and","a","large","loop","that","together","form","the","ligand","binding","domain",".","The","C-terminus","is","intracellular",".","The","ionotropic","glutamate","receptor","complex","itself","acts","as","a","ligand","gated","ion","channel",";","on","binding","glutamate",",","charged","ions","pass","through","a","channel","in","the","center","of","the","receptor","complex",".","Kainate","receptors","are","multimeric","assemblies","of","GluR5-7","and","KA-1/2","subunits","."),4337094). assertion_content_comment('tOboGo_KanamycinKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","kanamycin","=","ADP","+","2","H","(","+",")","+","kanamycin","3","'","-phosphate","."),4248500). assertion_content_comment('tOboGo_KAntigenBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","K","antigen",",","a","capsular","polysaccharide","antigen","carried","on","the","surface","of","bacterial","capsules","that","masks","somatic","(","O",")","antigens","."),4257379). assertion_content_comment('tOboGo_KAntigenMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","K","antigen",",","a","capsular","polysaccharide","antigen","carried","on","the","surface","of","bacterial","capsules","that","masks","somatic","(","O",")","antigens","."),4257376). assertion_content_comment('tOboGo_KaryogamyInvolvedInConjugationWithCellularFusion',s("During","sexual","reproduction",",","the","creation","of","a","single","nucleus","from","multiple","nuclei","as","a","result","of","fusing","the","lipid","bilayers","that","surround","each","nuclei",".","This","occurs","after","cytogamy","."),3977818). assertion_content_comment('tOboGo_KaryogamyInvolvedInConjugationWithMutualGeneticExchange',s("During","sexual","reproduction",",","the","creation","of","a","single","nucleus","from","multiple","nuclei","as","a","result","of","fusing","the","lipid","bilayers","that","surround","each","nuclei",".","This","occurs","after","the","mutual","exchange","of","nuclei","."),3977945). assertion_content_comment('tOboGo_Karyogamy',s("The","creation","of","a","single","nucleus","from","multiple","nuclei","as","a","result","of","fusing","the","lipid","bilayers","that","surround","each","nuclei","."),3977805). assertion_content_comment('tOboGo_KaryopherinDockingComplex',s("A","subcomplex","of","the","nuclear","pore","complex","that","interacts","with","karyopherin-cargo","complexes",";","a","well-characterized","example","in","Saccharomyces","contains","Asm4p",",","Nup53p",",","and","Nup170p","."),4061280). assertion_content_comment('tOboGo_KaryosomeFormation',s("The","chromosome","organization","process","in","which","meiotic","chromosomes","in","the","oocyte","nucleus","cluster","together","to","form","a","compact","spherical","structure","called","the","karyosome","."),4052172). assertion_content_comment('tOboGo_KataninComplex',s("A","complex","possessing","an","activity","that","couples","ATP","hydrolysis","to","the","severing","of","microtubules",";","usually","a","heterodimer","comprising","a","catalytic","subunit","(","often","60kDa",")","and","a","regulatory","subunit","(","often","80","kDa",")"),4020576). assertion_content_comment('tOboGo_KDELSequenceBinding',s("Interacting","selectively","and","non-covalently","with","a","KDEL","sequence",",","the","C","terminus","tetrapeptide","sequence","Lys-Asp-Glu-Leu","found","in","proteins","that","are","to","be","retained","in","the","endoplasmic","reticulum","."),4215157). assertion_content_comment('tOboGo_KdoTransferaseActivity',s("Catalysis","of","the","reactions",":","(","KDO",")","-lipid","IVA","+","CMP-3-deoxy-D-manno-octulosonate","=","KDO2-lipid","IVA","+","CMP",",","and","lipid","IVA","+","CMP-3-deoxy-D-manno-octulosonate","=","(","KDO",")","-lipid","IVA","+","CMP","."),4326963). assertion_content_comment('tOboGo_KeratanSulfateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","keratan","sulfate",",","a","glycosaminoglycan","with","repeat","units","consisting","of","beta-1",",","4-linked","D-galactopyranosyl-beta-","(","1",",","4",")","-N-acetyl-D-glucosamine","6-sulfate","and","with","variable","amounts","of","fucose",",","sialic","acid","and","mannose","units",";","keratan","sulfate","chains","are","covalently","linked","by","a","glycosidic","attachment","through","the","trisaccharide","galactosyl-galactosyl-xylose","to","peptidyl-threonine","or","serine","residues","."),4284828). assertion_content_comment('tOboGo_KeratanSulfateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","keratan","sulfate",",","a","glycosaminoglycan","with","repeat","units","consisting","of","beta-1",",","4-linked","D-galactopyranosyl-beta-","(","1",",","4",")","-N-acetyl-D-glucosamine","6-sulfate","and","with","variable","amounts","of","fucose",",","sialic","acid","and","mannose","units",";","keratan","sulfate","chains","are","covalently","linked","by","a","glycosidic","attachment","through","the","trisaccharide","galactosyl-galactosyl-xylose","to","peptidyl-threonine","or","serine","residues","."),4313123). assertion_content_comment('tOboGo_KeratanSulfateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","keratan","sulfate",",","a","glycosaminoglycan","with","repeat","units","consisting","of","beta-1",",","4-linked","D-galactopyranosyl-beta-","(","1",",","4",")","-N-acetyl-D-glucosamine","6-sulfate","and","with","variable","amounts","of","fucose",",","sialic","acid","and","mannose","units",";","keratan","sulfate","chains","are","covalently","linked","by","a","glycosidic","attachment","through","the","trisaccharide","galactosyl-galactosyl-xylose","to","peptidyl-threonine","or","serine","residues","."),4284822). assertion_content_comment('tOboGo_KeratanSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","keratan","=","adenosine","3","'",",","5","'","-bisphosphate","+","keratan","6","'","-sulfate","."),4300011). assertion_content_comment('tOboGo_KeratinFilament',s("A","filament","composed","of","acidic","and","basic","keratins","(","types","I","and","II",")",",","typically","expressed","in","epithelial","cells",".","The","keratins","are","the","most","diverse","classes","of","IF","proteins",",","with","a","large","number","of","keratin","isoforms","being","expressed",".","Each","type","of","epithelium","always","expresses","a","characteristic","combination","of","type","I","and","type","II","keratins","."),4301095). assertion_content_comment('tOboGo_Keratinization',s("The","process","in","which","the","cytoplasm","of","the","outermost","cells","of","the","vertebrate","epidermis","is","replaced","by","keratin",".","Keratinization","occurs","in","the","stratum","corneum",",","feathers",",","hair",",","claws",",","nails",",","hooves",",","and","horns","."),4058425). assertion_content_comment('tOboGo_KeratinocyteActivation',s("A","change","in","the","morphology","or","behavior","of","a","keratinocyte","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand",".","Upon","activation",",","keratinocytes","become","migratory","and","hyperproliferative",",","and","produce","growth","factors","and","cytokines","."),4337085). assertion_content_comment('tOboGo_KeratinocyteDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","keratinocyte","over","time",",","from","its","formation","to","the","mature","structure","."),4006287). assertion_content_comment('tOboGo_KeratinocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","keratinocyte","."),4006284). assertion_content_comment('tOboGo_KeratinocyteMigration',s("The","directed","movement","of","a","keratinocyte",",","epidermal","cells","which","synthesize","keratin",",","from","one","site","to","another","."),4118836). assertion_content_comment('tOboGo_KeratinocyteProliferation',s("The","multiplication","or","reproduction","of","keratinocytes",",","resulting","in","the","expansion","of","a","cell","population",".","Keratinocytes","are","epidermal","cells","which","synthesize","keratin","and","undergo","a","characteristic","change","as","they","move","upward","from","the","basal","layers","of","the","epidermis","to","the","cornified","(","horny",")","layer","of","the","skin","."),4036666). assertion_content_comment('tOboGo_KetoAcidFormateLyaseActivity',s("Catalysis","of","the","reaction",":","2-oxobutanoate","+","CoA","=","propionyl-CoA","+","formate","."),4327464). assertion_content_comment('tOboGo_KetogluconateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ketogluconate",",","the","anion","of","ketogluconic","acid",",","an","aldonic","acid","derived","from","glucose","containing","a","ketonic","carbonyl","group","."),4351694). assertion_content_comment('tOboGo_KetogluconateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ketogluconate",",","the","anion","of","ketogluconic","acid",",","an","aldonic","acid","derived","from","glucose","containing","a","ketonic","carbonyl","group","."),4351666). assertion_content_comment('tOboGo_KetogluconateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","ketogluconate",",","the","anion","of","ketogluconic","acid",",","an","aldonic","acid","derived","from","glucose","containing","a","ketonic","carbonyl","group","."),4242502). assertion_content_comment('tOboGo_KetohexokinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","D-fructose","=","ADP","+","D-fructose","1-phosphate","."),4206968). assertion_content_comment('tOboGo_KetoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ketones",",","a","class","of","organic","compounds","that","contain","the","carbonyl","group",",","CO",",","and","in","which","the","carbonyl","group","is","bonded","only","to","carbon","atoms",".","The","general","formula","for","a","ketone","is","RCOR",",","where","R","and","R","are","alkyl","or","aryl","groups","."),4015783). assertion_content_comment('tOboGo_KetoneBodyBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ketone","bodies",",","any","one","of","the","three","substances",":","acetoacetate",",","D-3-hydroxybutyrate","(","beta-hydroxybutyrate",")","or","acetone",".","Biosynthesis","involves","the","formation","of","hydroxymethylglutaryl-CoA",",","which","is","cleaved","to","acetate","and","acetyl-CoA","."),4362000). assertion_content_comment('tOboGo_KetoneBodyCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ketone","bodies",",","any","one","of","the","three","substances",":","acetoacetate",",","D-3-hydroxybutyrate","(","beta-hydroxybutyrate",")","or","acetone",".","Ketone","bodies","can","be","used","as","an","energy","source","as","an","alternative","to","glucose",".","Utilization","of","ketone","bodies","in","peripheral","tissues","involves","conversion","of","acetoacetate","to","acetoacetyl-CoA",",","which","is","then","converted","to","two","molecules","of","acetyl-CoA","."),4362016). assertion_content_comment('tOboGo_KetoneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ketones",",","a","class","of","organic","compounds","that","contain","the","carbonyl","group",",","CO",",","and","in","which","the","carbonyl","group","is","bonded","only","to","carbon","atoms",".","The","general","formula","for","a","ketone","is","RCOR",",","where","R","and","R","are","alkyl","or","aryl","groups","."),4027369). assertion_content_comment('tOboGo_KetoreductaseActivity',s("Catalysis","of","the","reduction","of","a","ketone","group","to","form","the","corresponding","alcohol","."),4297894). assertion_content_comment('tOboGo_KetosteroidMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","O2","+","NADPH","+","progesterone","=","H2O","+","NADP","+","+","testosterone","acetate","."),4364992). assertion_content_comment('tOboGo_KexinActivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","the","Arg-Xaa","bond","in","Lys-Arg-Xaa","and","Arg-Arg-Xaa","to","process","Yeast","alpha-factor","pheromone","and","killer","toxin","precursors","."),4209617). assertion_content_comment('tOboGo_KidneyDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","kidney","over","time",",","from","its","formation","to","the","mature","structure",".","The","kidney","is","an","organ","that","filters","the","blood","and/or","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),3984288). assertion_content_comment('tOboGo_KidneyEpitheliumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","epithelium","in","the","kidney","over","time",",","from","its","formation","to","the","mature","structure",".","An","epithelium","is","a","tissue","that","covers","the","internal","or","external","surfaces","of","an","anatomical","structure","."),4006061). assertion_content_comment('tOboGo_KidneyFieldSpecification',s("The","process","that","results","in","the","delineation","of","regions","of","the","embryo","into","the","area","in","which","the","kidney","rudiment","will","develop","."),4059214). assertion_content_comment('tOboGo_KidneyMesenchymalCellProliferation',s("The","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","mesenchymal","cell","population","in","the","kidney","."),4122845). assertion_content_comment('tOboGo_KidneyMesenchymeDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","kidney","mesenchyme","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","kidney","mesenchyme","and","ends","with","the","mature","structure",".","Kidney","mesenchyme","is","the","tissue","made","up","of","loosely","connected","mesenchymal","cells","in","the","kidney","."),4122773). assertion_content_comment('tOboGo_KidneyMesenchymeMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","kidney","mesenchymal","tissue","are","generated","and","organized",".","Kidney","mesenchyme","is","the","tissue","made","up","of","loosely","connected","mesenchymal","cells","in","the","kidney","."),4122793). assertion_content_comment('tOboGo_KidneyMorphogenesis',s("Morphogenesis","of","a","kidney",".","A","kidney","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4006030). assertion_content_comment('tOboGo_KidneyRudimentFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","kidney","rudiment","from","unspecified","parts",".","A","kidney","is","an","organ","that","filters","the","blood","and","excretes","the","end","products","of","body","metabolism","in","the","form","of","urine","."),4059211). assertion_content_comment('tOboGo_KidneySmoothMuscleCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","smooth","muscle","cell","in","the","kidney","."),4124892). assertion_content_comment('tOboGo_KidneySmoothMuscleTissueDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","smooth","muscle","in","the","kidney","over","time",",","from","its","formation","to","the","mature","structure","."),4124881). assertion_content_comment('tOboGo_KidneyStromaDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","kidney","stroma","over","time",",","from","its","formation","to","the","mature","structure",".","The","kidney","stroma","is","the","mesenchyme","of","the","mature","kidney","."),4158089). assertion_content_comment('tOboGo_KievitoneHydrataseActivity',s("Catalysis","of","the","reaction",":","kievitone","hydrate","=","H","(","2",")","O","+","H","(","+",")","+","kievitone","."),4270050). assertion_content_comment('tOboGo_KillerActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4234737). assertion_content_comment('tOboGo_KillingByHostOfSymbiontCells',s("Any","process","mediated","by","an","organism","that","results","in","the","death","of","cells","in","the","symbiont","organism",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4122245). assertion_content_comment('tOboGo_KillingBySymbiontOfHostCells',s("Any","process","mediated","by","an","organism","that","results","in","the","death","of","cells","in","the","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),3985724). assertion_content_comment('tOboGo_KillingOfCellsInOtherOrganismInvolvedInSymbioticInteraction',s("Any","process","mediated","by","an","organism","that","results","in","the","death","of","cells","in","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),3985721). assertion_content_comment('tOboGo_KillingOfCellsOfOtherOrganism',s("Any","process","in","an","organism","that","results","in","the","killing","of","cells","of","another","organism",",","including","in","some","cases","the","death","of","the","other","organism",".","Killing","here","refers","to","the","induction","of","death","in","one","cell","by","another","cell",",","not","cell-autonomous","death","due","to","internal","or","other","environmental","conditions","."),3985716). assertion_content_comment('tOboGo_KinaseActivatorActivity',s("Increases","the","activity","of","a","kinase",",","an","enzyme","which","catalyzes","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","substrate","molecule","."),4217300). assertion_content_comment('tOboGo_KinaseActivity',s("Catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","substrate","molecule","."),4157278). assertion_content_comment('tOboGo_KinaseBinding',s("Interacting","selectively","and","non-covalently","with","a","kinase",",","any","enzyme","that","catalyzes","the","transfer","of","a","phosphate","group","."),4073908). assertion_content_comment('tOboGo_KinaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","kinase",",","an","enzyme","which","catalyzes","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","substrate","molecule","."),4200311). assertion_content_comment('tOboGo_KinaseRegulatorActivity',s("Modulates","the","activity","of","a","kinase",",","an","enzyme","which","catalyzes","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","a","substrate","molecule","."),4200276). assertion_content_comment('tOboGo_KinesinBinding',s("Interacting","selectively","and","non-covalently","and","stoichiometrically","with","kinesin",",","a","member","of","a","superfamily","of","microtubule-based","motor","proteins","that","perform","force-generating","tasks","such","as","organelle","transport","and","chromosome","segregation","."),4233904). assertion_content_comment('tOboGo_KinesinComplex',s("Any","complex","that","includes","a","dimer","of","molecules","from","the","kinesin","superfamily",",","a","group","of","related","proteins","that","contain","an","extended","region","of","predicted","alpha-helical","coiled","coil","in","the","main","chain","that","likely","produces","dimerization",".","The","native","complexes","of","several","kinesin","family","members","have","also","been","shown","to","contain","additional","peptides",",","often","designated","light","chains","as","all","of","the","noncatalytic","subunits","that","are","currently","known","are","smaller","than","the","chain","that","contains","the","motor","unit",".","Kinesin","complexes","generally","possess","a","force-generating","enzymatic","activity",",","or","motor",",","which","converts","the","free","energy","of","the","gamma","phosphate","bond","of","ATP","into","mechanical","work","."),4221536). assertion_content_comment('tOboGo_KinesinIComplex',s("A","complex","of","two","kinesin","heavy","chains","and","two","kinesin","light","chains","."),4301883). assertion_content_comment('tOboGo_KinesinIIComplex',s("A","complex","consisting","of","two","distinct","motor","subunits","that","form","a","heterodimer","complexed","with","a","third","non-motor","accessory","subunit",",","the","kinesin","associated","protein","or","KAP",";","the","KIF3","heterodimer","interacts","via","its","C-terminal","portion","with","KAP",",","which","is","thought","to","regulate","the","binding","of","the","motor","to","cargo","membranes","."),4301892). assertion_content_comment('tOboGo_KinesinMotorActivity',s("OBSOLETE",".","The","hydrolysis","of","ATP","(","and","GTP",")","that","drives","the","microtubular","motor","along","microtubules","."),4304339). assertion_content_comment('tOboGo_Kinesis',s("The","movement","of","a","cell","or","organism","in","response","to","a","stimulus","in","which","the","rate","of","movement","depends","on","the","intensity","(","rather","than","the","direction",")","of","the","stimulus","."),4313293). assertion_content_comment('tOboGo_KinetochoreAssembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","kinetochore",",","a","multisubunit","complex","that","is","located","at","the","centromeric","region","of","DNA","and","provides","an","attachment","point","for","the","spindle","microtubules","."),4118227). assertion_content_comment('tOboGo_KinetochoreBinding',s("Interacting","selectively","and","non-covalently","with","a","kinetochore",",","a","proteinaceous","structure","on","a","condensed","chromosome",",","beside","the","centromere",",","to","which","the","spindle","fibers","are","attached","."),4324681). assertion_content_comment('tOboGo_KinetochoreMicrotubule',s("Any","of","the","spindle","microtubules","that","attach","to","the","kinetochores","of","chromosomes","by","their","plus","ends",",","and","maneuver","the","chromosomes","during","mitotic","or","meiotic","chromosome","segregation","."),4221730). assertion_content_comment('tOboGo_KinetochoreMotorActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4255173). assertion_content_comment('tOboGo_KinetochoreOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","kinetochore",",","a","multisubunit","complex","that","is","located","at","the","centromeric","region","of","DNA","and","provides","an","attachment","point","for","the","spindle","microtubules","."),4118221). assertion_content_comment('tOboGo_Kinetochore',s("A","multisubunit","complex","that","is","located","at","the","centromeric","region","of","DNA","and","provides","an","attachment","point","for","the","spindle","microtubules","."),3976696). assertion_content_comment('tOboGo_Kinetoplast',s("A","sub-structure","within","the","large","single","mitochondrion","of","kinetoplastid","parasites","and","which","is","closely","associated","with","the","flagellar","pocket","and","basal","body","of","the","flagellum","."),4079994). assertion_content_comment('tOboGo_KininCascade',s("A","series","of","reactions","that","takes","place","outside","the","cell","that","occur","as","a","result","of","by-products","of","tissue","damage",",","including","collagen",",","cartilage",",","and","basement","membrane",".","The","ultimate","product","of","the","kinin","cascade","include","kallidin","and","bradykinin",",","agents","known","to","induce","smooth","muscle","contraction",",","vasoconstriction",",","and","increased","vascular","permeability","."),3992132). assertion_content_comment('tOboGo_KininogenBinding',s("Interacting","selectively","and","non-covalently","with","a","kininogen",",","any","of","a","group","of","plasma","proteins","that","are","kinin","precursors","."),4307223). assertion_content_comment('tOboGo_Kinocilium',s("A","nonmotile","primary","cilium","that","is","found","at","the","apical","surface","of","auditory","receptor","cells",".","The","kinocilium","is","surrounded","by","actin-based","stereocilia","."),4108709). assertion_content_comment('tOboGo_KisspeptinReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","kisspeptin","receptor","."),4322821). assertion_content_comment('tOboGo_Klinokinesis',s("The","movement","of","a","cell","or","organism","in","response","to","a","stimulus","in","which","the","frequency","or","magnitude","of","turning","behavior","is","altered","."),4313304). assertion_content_comment('tOboGo_KojibiosePhosphorylaseActivity',s("Catalysis","of","the","reaction",":","kojibiose","+","phosphate","=","beta-D-glucose","1-phosphate","+","D-glucose","."),4343139). assertion_content_comment('tOboGo_KU70Binding',s("Interacting","selectively","and","non-covalently","with","Ku70",",","a","protein","involved","in","non-homologous","DNA","end","joining","."),4258303). assertion_content_comment('tOboGo_Ku70_Ku80Complex',s("Heterodimeric","protein","complex","composed","of","a","70","kDa","and","a","80","kDa","subunit",",","binds","DNA","through","a","channel","formed","by","the","heterodimer",".","Functions","in","DNA","double","stranded","break","repair",",","chromosome","maintenance",",","transcription","regulation",",","V","(","D",")","J","recombination",",","and","activation","of","DNA-PK","."),4325395). assertion_content_comment('tOboGo_KupfferSVesicleDevelopment',s("The","progression","of","the","Kupffer","'","s","vesicle","over","time","from","its","initial","formation","until","its","mature","state",".","The","Kupffer","'","s","vesicle","is","a","small","but","distinctive","epithelial","sac","containing","fluid",",","located","midventrally","posterior","to","the","yolk","cell","or","its","extension",",","and","transiently","present","during","most","of","the","segmentation","period","."),4179933). assertion_content_comment('tOboGo_KynurenicAcidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","kynurenic","acid",",","4-hydroxyquinoline-2-carboxylic","acid","."),4360282). assertion_content_comment('tOboGo_KynurenicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","kynurenic","acid",",","4-hydroxyquinoline-2-carboxylic","acid","."),4360269). assertion_content_comment('tOboGo_KynureninaseActivity',s("Catalysis","of","the","reaction",":","L-kynurenine","+","H2O","=","anthranilate","+","L-alanine","."),4309999). assertion_content_comment('tOboGo_KynurenineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","kynurenine",",","the","amino","acid","3-","(","2-aminobenzoyl",")","-alanine","."),4179318). assertion_content_comment('tOboGo_L27DomainBinding',s("Interacting","selectively","and","non-covalently","with","a","L27","domain","of","a","protein",".","L27","is","composed","of","conserved","negatively","charged","amino","acids","and","a","conserved","aromatic","amino","acid",".","L27","domains","can","assemble","proteins","involved","in","signaling","and","establishment","and","maintenance","of","cell","polarity","into","complexes","by","interacting","in","a","heterodimeric","manner","."),4073816). assertion_content_comment('tOboGo_LabialDiscDevelopment',s("Progression","of","the","labial","imaginal","disc","over","time",",","from","its","initial","formation","through","to","its","metamorphosis","to","form","adult","structures","including","parts","of","the","proboscis","."),4017738). assertion_content_comment('tOboGo_LabialDiscMorphogenesis',s("The","process","in","which","the","anatomical","structures","derived","from","the","labial","disc","are","generated","and","organized",".","This","includes","the","transformation","of","a","labial","imaginal","disc","from","a","monolayered","epithelium","in","the","larvae","of","holometabolous","insects","into","recognizable","adult","structures","including","parts","of","the","proboscis","."),4017748). assertion_content_comment('tOboGo_LabrumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","labrum","over","time",",","from","its","formation","to","the","mature","structure","."),4107292). assertion_content_comment('tOboGo_LabrumMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","labrum","are","generated","and","organized","."),4107356). assertion_content_comment('tOboGo_LabyrinthineLayerBloodVesselDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","blood","vessel","of","the","labyrinthine","layer","of","the","placenta","over","time",",","from","its","formation","to","the","mature","structure",".","The","embryonic","vessels","grow","through","the","layer","to","come","in","close","contact","with","the","maternal","blood","supply","."),4112675). assertion_content_comment('tOboGo_LabyrinthineLayerDevelopment',s("The","process","in","which","the","labyrinthine","layer","of","the","placenta","progresses",",","from","its","formation","to","its","mature","state","."),4112439). assertion_content_comment('tOboGo_LabyrinthineLayerFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","labyrinthine","layer","of","the","placenta","."),4112654). assertion_content_comment('tOboGo_LabyrinthineLayerMorphogenesis',s("The","process","in","which","the","labyrinthine","layer","of","the","placenta","is","generated","and","organized","."),4112470). assertion_content_comment('tOboGo_LaccaseActivity',s("Catalysis","of","the","reaction",":","4","benzenediol","+","O2","=","4","benzosemiquinone","+","2","H2O","."),4254297). assertion_content_comment('tOboGo_LacrimalGlandDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","lacrimal","gland","over","time",",","from","its","formation","to","the","mature","structure",".","The","lacrimal","gland","produces","secretions","that","lubricate","and","protect","the","cornea","of","the","eye","."),4070482). assertion_content_comment('tOboGo_LactaldehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-lactaldehyde","+","NAD","+","+","H2O","=","(","S",")","-lactate","+","NADH","+","H","+"),4248487). assertion_content_comment('tOboGo_LactaldehydeReductaseActivity',s("Catalysis","of","the","reaction",":","propane-1",",","2-diol","+","NAD","+","=","lactaldehyde","+","NADH","+","H","+"),4192006). assertion_content_comment('tOboGo_LactaldehydeReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","propane-1",",","2-diol","=","(","S",")","-lactaldehyde","+","H","(","+",")","+","NADPH","."),4270339). assertion_content_comment('tOboGo_LactaseActivity',s("Catalysis","of","the","reaction",":","lactose","+","H2O","=","D-glucose","+","D-galactose","."),4345344). assertion_content_comment('tOboGo_LactateAldolaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-lactate","=","acetaldehyde","+","formate","."),4270238). assertion_content_comment('tOboGo_LactateBiosyntheticProcessFromPyruvate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lactate","from","other","compounds",",","including","pyruvate","."),4238420). assertion_content_comment('tOboGo_LactateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lactate",",","the","anion","of","lactic","acid","."),4238397). assertion_content_comment('tOboGo_LactateChannelActivity',"OBSOLETE.",4295379). assertion_content_comment('tOboGo_LactateDehydrogenaseActivity',s("Catalysis","of","the","oxidation","of","lactate","to","produce","pyruvate","."),4205737). assertion_content_comment('tOboGo_LactateFermentationToPropionateAndAcetate',s("The","anaerobic","enzymatic","conversion","of","lactate","to","propionate",",","concomitant","with","the","oxidation","of","lactate","to","acetate","and","CO2","and","yielding","energy","in","the","form","of","adenosine","triphosphate","(","ATP",")"),4244266). assertion_content_comment('tOboGo_Lactate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","lactate","(","out",")","+","H","+","(","out",")","=","lactate","(","in",")","+","H","+","(","in",")"),4290235). assertion_content_comment('tOboGo_LactateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lactate",",","the","anion","of","lactic","acid","."),4224534). assertion_content_comment('tOboGo_LactateOxidation',s("The","chemical","reactions","and","pathways","resulting","in","the","conversion","of","lactate","to","other","compounds",",","such","as","pyruvate",",","with","concomitant","loss","of","electrons","."),4242265). assertion_content_comment('tOboGo_LactateRacemaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-lactate","=","(","R",")","-lactate","."),4270261). assertion_content_comment('tOboGo_LactateRacemization',s("Partial","conversion","of","one","lactate","enantiomer","into","another","so","that","the","specific","optical","rotation","is","decreased",",","or","even","reduced","to","zero",",","in","the","resulting","mixture","."),4238525). assertion_content_comment('tOboGo_LactateTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","lactate","from","one","side","of","the","membrane","to","the","other",".","Lactate","is","2-hydroxypropanoate",",","CH3-CHOH-COOH",";","L","(","+",")","-lactate","is","formed","by","anaerobic","glycolysis","in","animal","tissues",",","and","DL-lactate","is","found","in","sour","milk",",","molasses","and","certain","fruit","juices","."),4290231). assertion_content_comment('tOboGo_LactateTransport',s("The","directed","movement","of","lactate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Lactate","is","2-hydroxypropanoate",",","CH3-CHOH-COOH",";","L","(","+",")","-lactate","is","formed","by","anaerobic","glycolysis","in","animal","tissues",",","and","DL-lactate","is","found","in","sour","milk",",","molasses","and","certain","fruit","juices","."),4290856). assertion_content_comment('tOboGo_Lactation',s("The","secretion","of","milk","by","the","mammary","gland","."),4015270). assertion_content_comment('tOboGo_LacticAcidSecretion',s("The","controlled","release","of","lactic","acid",",","2-hydroxypropanoic","acid",",","by","a","cell","or","group","of","cells","."),4356939). assertion_content_comment('tOboGo_LactoferrinReceptorActivity',s("Combining","with","lactoferrin","to","initiate","a","change","in","cell","activity","."),4340331). assertion_content_comment('tOboGo_LactoferrinTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","lactoferrin","from","one","side","of","a","membrane","to","the","other","."),4340322). assertion_content_comment('tOboGo_LactoferrinTransport',s("The","directed","movement","of","lactoferrin","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4340383). assertion_content_comment('tOboGo_LactoneTransmembraneTransporterActivity',s("Enables","the","directed","movement","of","lactone","from","one","side","of","a","membrane","to","the","other",".","A","lactone","is","a","cyclic","ester","of","a","hydroxy","carboxylic","acid",",","containing","a","1-oxacycloalkan-2-one","structure",",","or","an","analogue","having","unsaturation","or","heteroatoms","replacing","one","or","more","carbon","atoms","of","the","ring","."),4316146). assertion_content_comment('tOboGo_LactoneTransport',s("The","directed","movement","of","lactone","from","one","side","of","a","membrane","to","the","other",".","A","lactone","is","a","cyclic","ester","of","a","hydroxy","carboxylic","acid",",","containing","a","1-oxacycloalkan-2-one","structure",",","or","an","analogue","having","unsaturation","or","heteroatoms","replacing","one","or","more","carbon","atoms","of","the","ring","."),4316210). assertion_content_comment('tOboGo_LactonohydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","lactone","rings","(","intramolecular","cyclic","esters",")","to","produce","a","hydroxyl","group","and","a","carboxyl","group","."),4221831). assertion_content_comment('tOboGo_LactoseBinding',s("Interacting","selectively","and","non-covalently","with","lactose",",","a","disaccharide","of","glucose","and","galactose",",","the","carbohydrate","of","milk","."),4309369). assertion_content_comment('tOboGo_LactoseBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lactose",",","the","disaccharide","galactopyranosyl-glucose","."),4221263). assertion_content_comment('tOboGo_LactoseCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lactose",",","the","disaccharide","galactopyranosyl-glucose","."),4220917). 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assertion_content_comment('tOboGo_LactoseHydrolysis',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4242242). assertion_content_comment('tOboGo_LactoseMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lactose",",","the","disaccharide","galactopyranosyl-glucose","."),4220913). assertion_content_comment('tOboGo_LactoseSynthaseActivity',s("Catalysis","of","the","reaction",":","UDP-galactose","+","D-glucose","=","UDP","+","lactose","."),4205845). assertion_content_comment('tOboGo_LactoseTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","lactose","from","one","side","of","the","membrane","to","the","other",".","Lactose","is","a","disaccharide","4-O-beta-D-galactopyranosyl-D-glucose",",","and","constitutes","roughly","5","%","of","the","milk","in","almost","all","mammals","."),4293082). 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assertion_content_comment('tOboGo_LamellipodiumAssemblyInvolvedInMesendodermalCellMigration',s("Formation","of","a","lamellipodium",",","a","thin","sheetlike","extension","of","the","surface","of","a","migrating","cell","that","contributes","to","the","directed","self-propelled","movement","of","a","mesendodermal","cell","."),4005744). assertion_content_comment('tOboGo_LamellipodiumAssembly',s("Formation","of","a","lamellipodium",",","a","thin","sheetlike","extension","of","the","surface","of","a","migrating","cell","."),4005734). assertion_content_comment('tOboGo_LamellipodiumMembrane',s("The","portion","of","the","plasma","membrane","surrounding","a","lamellipodium","."),4062349). assertion_content_comment('tOboGo_LamellipodiumMorphogenesis',s("A","process","that","is","carried","out","at","the","cellular","level","and","in","which","the","structure","of","a","lamellipodium","is","organized","."),4142438). assertion_content_comment('tOboGo_Lamellipodium',s("A","thin","sheetlike","process","extended","by","the","leading","edge","of","a","crawling","fibroblast",";","contains","a","dense","meshwork","of","actin","filaments","."),4052708). assertion_content_comment('tOboGo_LamellocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","hemocyte","precursor","cell","acquires","the","specialized","features","of","a","lamellocyte",".","Lamellocytes","are","a","hemocyte","lineage","that","exists","only","in","larvae",",","but","are","seldom","observed","in","healthy","animals",".","Lamellocytes","differentiate","massively","in","the","lymph","glands","after","parasitization","and","are","large","flat","cells","devoted","to","encapsulation","of","invaders","too","large","to","be","phagocytosed","by","plasmatocytes","."),4072163). assertion_content_comment('tOboGo_LaminaDensa',s("The","electron-dense","layer","of","the","basal","lamina",";","lies","just","below","the","lamina","lucida","."),4015990). assertion_content_comment('tOboGo_LaminaLucida',s("The","electron-lucent","layer","of","the","basal","lamina","adjacent","to","the","basal","plasma","membrane","of","the","cells","that","rest","on","the","lamina","."),4015970). assertion_content_comment('tOboGo_LaminaReticularis',s("A","layer","of","the","basal","lamina","that","contains","collagen","fibrils","and","connects","the","basal","lamina","to","the","underlying","connective","tissue","."),4015980). assertion_content_comment('tOboGo_LaminaribiosePhosphorylaseActivity',s("Catalysis","of","the","reaction",":","3-beta-D-glucosyl-D-glucose","+","phosphate","=","D-glucose","+","alpha-D-glucose","1-phosphate","."),4270285). assertion_content_comment('tOboGo_LaminaTerminalisFormation',s("The","process","in","which","the","anterior-most","portion","of","the","neural","axis","is","formed","by","closure","of","the","anterior","neuropore","."),4046492). assertion_content_comment('tOboGo_LaminBinding',s("Interacting","selectively","and","non-covalently","with","lamin",";","any","of","a","group","of","intermediate-filament","proteins","that","form","the","fibrous","matrix","on","the","inner","surface","of","the","nuclear","envelope","."),4193558). assertion_content_comment('tOboGo_LaminChromatinBinding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4193562). assertion_content_comment('tOboGo_LaminDepolymerization',s("The","cell","cycle","process","in","which","lamin","is","depolymerized","."),4012722). assertion_content_comment('tOboGo_LaminFilament',s("Any","of","a","group","of","intermediate-filament","proteins","that","form","the","fibrous","matrix","on","the","inner","surface","of","the","nuclear","envelope",".","They","are","classified","as","lamins","A",",","B","and","C","."),4007062). assertion_content_comment('tOboGo_LamininBinding',s("Interacting","selectively","and","non-covalently","with","laminins",",","glycoproteins","that","are","major","constituents","of","the","basement","membrane","of","cells","."),4318555). assertion_content_comment('tOboGo_LamininComplex',s("A","large",",","extracellular","glycoprotein","complex","composed","of","three","different","polypeptide","chains",",","alpha",",","beta","and","gamma",".","Provides","an","integral","part","of","the","structural","scaffolding","of","basement","membranes","."),4093300). assertion_content_comment('tOboGo_LamininReceptorActivity',s("Combining","with","a","laminin",",","a","glycoprotein","that","constitutes","the","majority","of","proteins","in","the","basement","membrane",",","to","initiate","a","change","in","cell","activity","."),4214874). assertion_content_comment('tOboGo_LamininReceptorProtein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220010). assertion_content_comment('tOboGo_LandsOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","Lands",",","a","class","of","nuclear","body","that","react","against","SP140","auto-antibodies","."),4307772). assertion_content_comment('tOboGo_LangerhansCellChemotaxis',s("The","movement","of","a","Langerhans","cell","in","response","to","an","external","stimulus","."),4381399). assertion_content_comment('tOboGo_LanosterolSynthaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2",",","3-epoxysqualene","=","lanosterol",".","This","is","a","cyclization","reaction","that","forms","the","sterol","nucleus","."),4346309). assertion_content_comment('tOboGo_LargeRibosomalSubunit',s("The","larger","of","the","two","subunits","of","a","ribosome",".","Two","sites","on","the","ribosomal","large","subunit","are","involved","in","translation",",","namely","the","aminoacyl","site","(","A","site",")","and","peptidyl","site","(","P","site",")"),3974548). assertion_content_comment('tOboGo_LargeUnchargedPolarMoleculeTransmembraneTransporterActivity',s("OBSOLETE",".","Catalysis","of","the","transfer","of","a","large","uncharged","polar","molecule","from","one","side","of","a","membrane","to","the","other","."),4331123). assertion_content_comment('tOboGo_LariciresinolReductaseActivity',s("Catalysis","of","the","reaction",":","lariciresinol","+","NADPH","+","H","+","=","secoisolariciresinol","+","NADP","+"),4335188). assertion_content_comment('tOboGo_LarvalBehavior',s("Behavior","in","a","larval","form","of","an","organism",",","an","immature","organism","that","must","undergo","metamorphosis","to","assume","adult","characteristics","."),4234963). assertion_content_comment('tOboGo_LarvalBehaviorSensuDrosophila',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4245670). assertion_content_comment('tOboGo_LarvalBehaviorSensuInsecta',s("OBSOLETE",".","Behavior","in","a","larval","form","of","an","organism",",","an","immature","organism","that","must","undergo","metamorphosis","to","assume","adult","characteristics",",","as","seen","in","insects","."),4234967). assertion_content_comment('tOboGo_LarvalBurrowingBehavior',s("Digging","into","the","substrate","by","non-feeding","larvae","in","search","for","food-free","sites","suitable","for","pupation","."),4382018). assertion_content_comment('tOboGo_LarvalCentralNervousSystemRemodeling',s("Reorganization","of","the","pre-existing",",","functional","larval","central","nervous","system","into","one","that","can","serve","the","novel","behavioral","needs","of","the","adult",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4071978). assertion_content_comment('tOboGo_LarvalDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","larva","over","time",",","from","its","formation","to","the","mature","structure",".","The","larva","is","the","early",",","immature","form","of","an","that","at","birth","or","hatching","is","fundamentally","unlike","its","parent","and","must","metamorphose","before","assuming","the","adult","characters","."),4017469). assertion_content_comment('tOboGo_LarvalFatBodyDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","larval","fat","body","over","time",",","from","its","formation","to","the","mature","structure",".","The","larval","fat","body","consists","of","a","bilaterally","symmetrical","monolayer","of","cells","lying","between","the","gut","and","the","muscles","of","the","body","wall",".","As","in","other","tissues","of","the","larva",",","the","cells","of","the","fat","body","complete","their","divisions","in","the","embryo","and","increase","in","size","and","ploidy","during","larval","life","."),4018365). assertion_content_comment('tOboGo_LarvalFeedingBehaviorSensuInsecta',s("OBSOLETE",".","Feeding","behavior","in","an","insect","larva","."),4255129). assertion_content_comment('tOboGo_LarvalFeedingBehavior',s("Feeding","behavior","in","a","larval","(","immature",")","organism","."),4255125). assertion_content_comment('tOboGo_LarvalForagingBehavior',s("The","movement","of","a","larva","through","a","feeding","substrate","whilst","feeding","on","food","."),4382029). assertion_content_comment('tOboGo_LarvalHeartDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","larval","heart","over","time",",","from","its","formation","to","the","mature","structure",".","In","Drosophila","the","larval","heart","(","dorsal","vessel",")","is","a","continuous","tube","of","mesodormal","cells","that","runs","beneath","the","dorsal","midline","of","the","epidermis",",","divided","into","an","anterior","aorta","and","a","posterior","heart","proper","."),4018334). assertion_content_comment('tOboGo_LarvalLocomotoryBehavior',s("Locomotory","behavior","in","a","larval","(","immature",")","organism","."),4255140). assertion_content_comment('tOboGo_LarvalLymphGlandHemocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","derived","from","the","larval","lymph","gland","acquires","the","specialized","features","of","a","mature","hemocyte",".","The","lymph","gland","consists","of","three","to","six","bilaterally","paired","lobes","that","are","attached","to","the","cardioblasts","during","larval","stages",",","and","it","degenerates","during","pupal","stages",".","Hemocytes","are","blood","cells","associated","with","a","hemocoel","(","the","cavity","containing","most","of","the","major","organs","of","the","arthropod","body",")","which","are","involved","in","defense","and","clotting","of","hemolymph",",","but","not","involved","in","transport","of","oxygen",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4072087). assertion_content_comment('tOboGo_LarvalLymphGlandHemopoiesis',s("The","production","of","blood","cells","from","the","larval","lymph","gland",".","The","lymph","gland","consists","of","three","to","six","bilaterally","paired","lobes","that","are","attached","to","the","cardioblasts","during","larval","stages",",","and","it","degenerates","during","pupal","stages","."),4072074). assertion_content_comment('tOboGo_LarvalMidgutCellProgrammedCellDeath',s("The","stage-specific","programmed","cell","death","of","cells","of","the","larval","midgut",",","during","histolysis","of","the","larval","organ","."),4073108). assertion_content_comment('tOboGo_LarvalMidgutHistolysis',s("The","stage-specific","break","down","of","the","larval","midgut","during","Drosophila","metamorphosis",",","to","allow","replacement","of","larval","structures","by","tissues","and","structures","that","form","the","adult","fly","."),4072798). assertion_content_comment('tOboGo_LarvalSalivaryGlandBoundarySpecification',s("Determination","in","a","larval","organism","of","where","the","salivary","gland","forms",",","the","total","number","of","salivary","gland","cells","and","how","many","cells","are","allocated","to","each","of","the","specialised","cell","types","within","the","salivary","gland","."),4017482). assertion_content_comment('tOboGo_LarvalSalivaryGlandMorphogenesis',s("The","process",",","occurring","in","the","larva",",","by","which","the","anatomical","structures","of","the","salivary","gland","are","generated","and","organized","."),4017533). assertion_content_comment('tOboGo_LarvalSerumProteinComplex',s("A","multisubunit","protein","complex","which",",","in","Drosophila",",","is","a","heterohexamer","of","three","subunits",",","alpha",",","beta","and","gamma",".","The","complex","is","thought","to","store","amino","acids","for","synthesis","of","adult","proteins","."),4006943). assertion_content_comment('tOboGo_LarvalSerumProteinSensuInsecta',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4216949). assertion_content_comment('tOboGo_LarvalSomaticMuscleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","larval","somatic","muscle","over","time",",","from","its","formation","to","the","mature","structure","."),4018550). assertion_content_comment('tOboGo_LarvalTurningBehavior',s("Fine-tuning","the","spatial","position","of","a","larva","in","response","to","variability","in","their","environment",".","For","example",",","reorientation","of","a","larva","in","the","direction","of","a","food","source","."),4382040). assertion_content_comment('tOboGo_LarvalVisceralMuscleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","larval","visceral","muscle","over","time",",","from","its","formation","to","the","mature","structure","."),4018590). assertion_content_comment('tOboGo_LarvalWalkingBehavior',s("The","actions","or","reactions","of","a","larval","organism","relating","to","the","progression","of","that","organism","along","the","ground","by","the","process","of","lifting","and","setting","down","each","leg","."),4255150). assertion_content_comment('tOboGo_LarvalWanderingBehavior',s("The","movement","of","a","third","instar","larva","through","a","substrate","in","search","of","a","pupation","site",".","This","movement","occurs","without","feeding","and","is","characterized","by","short","bursts","of","forward","movement",",","separated","by","stops","and","repeated","side-to-side","head","probes",",","followed","normally","by","a","change","in","direction","."),4382008). assertion_content_comment('tOboGo_LateDistalConvolutedTubuleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","late","distal","convoluted","tubule","over","time",",","from","its","formation","to","the","mature","structure",".","The","late","distal","convoluted","tubule","contains","DCT","cells","and","intercalated","(","IC",")","alpha","and","beta","cells","and","is","vasopressin-sensitive","."),4123743). assertion_content_comment('tOboGo_LateEndosomeLumen',s("The","volume","enclosed","by","the","membrane","of","a","late","endosome","."),4057224). assertion_content_comment('tOboGo_LateEndosomeMembrane',s("The","lipid","bilayer","surrounding","a","late","endosome","."),4057253). assertion_content_comment('tOboGo_LateEndosome',s("A","prelysosomal","endocytic","organelle","differentiated","from","early","endosomes","by","lower","lumenal","pH","and","different","protein","composition",".","Late","endosomes","are","more","spherical","than","early","endosomes","and","are","mostly","juxtanuclear",",","being","concentrated","near","the","microtubule","organizing","center","."),4057202). assertion_content_comment('tOboGo_LateEndosomeToGolgiTransport',s("The","directed","movement","of","substances","from","late","endosomes","to","the","Golgi","."),4357484). assertion_content_comment('tOboGo_LateEndosomeToVacuoleTransport',s("The","directed","movement","of","substances","from","late","endosomes","to","the","vacuole",".","In","yeast",",","after","transport","to","the","prevacuolar","compartment",",","endocytic","content","is","delivered","to","the","late","endosome","and","on","to","the","vacuole",".","This","pathway","is","analogous","to","endosome","to","lysosome","transport","."),4095657). assertion_content_comment('tOboGo_LateEndosomeToVacuoleTransportViaMultivesicularBodySortingPathway',s("The","directed","movement","of","substances","from","endosomes","to","vacuoles","by","a","pathway","in","which","molecules","are","sorted","into","multivesicular","bodies",",","which","then","fuse","with","the","vacuole","."),4095659). assertion_content_comment('tOboGo_LateMeioticRecombinationNoduleAssembly',s("During","meiosis",",","the","aggregation",",","arrangement","and","bonding","together","of","strand","exchange","proteins","(","recombinases",")","to","form","small",",","electron","dense","structures","in","association","with","meiotic","chromosomes","during","pachytene",".","Involved","in","the","catalysis","crossing","over","."),4313962). assertion_content_comment('tOboGo_LatentVirusInfection',s("A","viral","process","characterized","by","(","a",")","the","lack","of","efficient","expression","of","all","the","viral","genes","that","are","transcribed","during","productive","infection",",","and","(","b",")","the","activation","of","a","unique","latent","transcriptional","progam","."),4045168). assertion_content_comment('tOboGo_LatentVirusMaintenance',s("Any","process","required","for","maintaining","the","latent","form","of","the","viral","genome","within","a","cell","."),4045198). assertion_content_comment('tOboGo_LatentVirusReplication',s("Any","process","required","for","latent","viral","replication","in","a","cell","."),4045188). assertion_content_comment('tOboGo_LateralElementAssembly',s("The","cell","cycle","process","in","which","lateral","elements","are","formed",".","Axial","elements","form","a","proteinaceous","core","between","the","two","sister","chromatids","of","each","chromosome",";","the","two","axial","elements","then","connect","along","their","entire","lengths","by","fine","fibers","known","as","transverse","filaments",",","forming","the","lateral","elements","."),4122530). assertion_content_comment('tOboGo_LateralElement',s("A","proteinaceous","core","found","between","sister","chromatids","during","meiotic","prophase","."),3978398). assertion_content_comment('tOboGo_LateralGanglionicEminenceCellProliferation',s("The","multiplication","or","reproduction","of","lateral","ganglionic","eminence","cells",",","resulting","in","the","expansion","of","the","cell","population","."),4053439). assertion_content_comment('tOboGo_LateralGeniculateNucleusDevelopment',s("The","progression","of","the","lateral","geniculate","nucleus","over","time","from","its","initial","formation","until","its","mature","state",".","The","lateral","geniculate","nucleus","is","the","primary","processor","of","visual","information","received","from","the","retina","."),4049220). 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assertion_content_comment('tOboGo_LateralLineGanglionDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","lateral","line","ganglion","over","time",",","from","its","formation","to","the","mature","structure",".","The","lateral","line","ganglion","develops","from","cranial","ectodermal","placodes","situated","between","the","eye","and","ear","and","behind","the","ear","."),4105780). assertion_content_comment('tOboGo_LateralLineGanglionNeuronDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","lateral","line","ganglion","neuron","."),4105895). 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assertion_content_comment('tOboGo_LateralMotorColumnNeuronDifferentiation',s("The","process","in","which","differentiating","motor","neurons","in","the","neural","tube","acquire","the","specialized","structural","and/or","functional","features","of","lateral","motor","column","neurons",".","Lateral","motor","column","neurons","are","generated","only","on","limb","levels","and","send","axons","into","the","limb","mesenchyme",".","Differentiation","includes","the","processes","involved","in","commitment","of","a","cell","to","a","specific","fate","."),4041352). assertion_content_comment('tOboGo_LateralPartOfMotileCell',s("The","area","of","a","motile","cell","perpendicular","to","the","direction","of","movement","."),4320066). assertion_content_comment('tOboGo_LateralPlasmaMembrane',s("The","membranes","on","the","sides","of","epithelial","cells","which","lie","at","the","interface","of","adjacent","cells","."),4304348). assertion_content_comment('tOboGo_LateralPseudopodiumAssembly',s("The","extension","of","a","pseudopodium","from","the","lateral","area","of","a","cell","."),4059475). assertion_content_comment('tOboGo_LateralReticularNucleusDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","lateral","reticular","nucleus","over","time",",","from","its","formation","to","the","mature","structure","."),4042721). assertion_content_comment('tOboGo_LateralRootDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","lateral","root","over","time",",","from","its","formation","to","the","mature","structure",".","A","lateral","root","is","one","formed","from","pericycle","cells","located","on","the","xylem","radius","of","the","root",",","as","opposed","to","the","initiation","of","the","main","root","from","the","embryo","proper","."),4030565). assertion_content_comment('tOboGo_LateralRootFormation',s("The","process","that","gives","rise","to","a","lateral","root",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4030577). assertion_content_comment('tOboGo_LateralRootMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","lateral","root","are","generated","and","organized",".","A","lateral","root","is","one","formed","from","pericycle","cells","located","on","the","xylem","radius","of","the","root",",","as","opposed","to","the","initiation","of","the","main","root","from","the","embryo","proper","."),4030567). assertion_content_comment('tOboGo_LateralRootPrimordiumDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","lateral","root","primordium","over","time",",","which","initiates","the","formation","to","the","mature","structure",".","A","lateral","root","primordium","represents","an","organized","group","of","cells","derived","from","the","root","pericycle","that","will","differentiate","into","a","new","root",",","as","opposed","to","the","initiation","of","the","main","root","from","the","embryo","proper","."),4332260). assertion_content_comment('tOboGo_LateralSemicircularCanalDevelopment',s("The","progession","of","the","lateral","semicircular","canal","from","its","initial","formation","to","the","mature","structure","."),4156422). assertion_content_comment('tOboGo_LateralSproutingFromAnEpithelium',s("The","process","in","which","a","branch","forms","along","the","side","of","an","epithelium","."),4112228). assertion_content_comment('tOboGo_LateralSproutingInvolvedInLungMorphogenesis',s("The","process","in","which","a","branch","forms","along","the","side","of","the","lung","epithelial","tube","."),4117603). assertion_content_comment('tOboGo_LateralSproutingInvolvedInMammaryGlandDuctMorphogenesis',s("The","process","in","which","a","branch","forms","along","the","side","of","a","mammary","duct","."),4116940). assertion_content_comment('tOboGo_LateralSproutingInvolvedInUretericBudMorphogenesis',s("The","process","in","which","a","branch","forms","along","the","side","of","a","ureteric","bud","."),4112231). assertion_content_comment('tOboGo_LateralVentricleDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","lateral","ventricles","over","time",",","from","the","formation","to","the","mature","structure",".","The","two","lateral","ventricles","are","a","cavity","in","each","of","the","cerebral","hemispheres","derived","from","the","cavity","of","the","embryonic","neural","tube",".","They","are","separated","from","each","other","by","the","septum","pellucidum",",","and","each","communicates","with","the","third","ventricle","by","the","foramen","of","Monro",",","through","which","also","the","choroid","plexuses","of","the","lateral","ventricles","become","continuous","with","that","of","the","third","ventricle","."),4043612). assertion_content_comment('tOboGo_LateRecombinationNodule',s("An","electron","dense","structure","that","is","associated","with","meiotic","chromosomes","in","pachytene","during","meiosis","I","."),4219758). assertion_content_comment('tOboGo_LateStripeMelanocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","late","stripe","melanocyte","(","LSM",")","In","zebrafish",",","LSMs","develop","during","the","second","phase","(","3-4","weeks","of","development",")","of","the","larva-to-adult","transition","(","2-4","weeks","of","development",")"),4099900). assertion_content_comment('tOboGo_LateViralMRNATranscription',s("The","last","group","of","viral","genes","to","be","transcribed","during","the","viral","life","cycle",";","genes","consist","mainly","of","those","encoding","structural","proteins","."),4236748). assertion_content_comment('tOboGo_LathosterolOxidaseActivity',s("Catalysis","of","the","reaction",":","5-alpha-cholest-7-en-3-beta-ol","+","O2","=","cholesta-5",",","7-dien-3-beta-ol","+","H2O2","."),4270204). assertion_content_comment('tOboGo_LatrotoxinReceptorActivity',s("Combining","with","alpha-latrotoxin",",","a","potent","presynaptic","neurotoxin",",","to","initiate","a","change","in","cell","activity","."),4305159). assertion_content_comment('tOboGo_LauricAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lauric","acid",",","a","fatty","acid","with","the","formula","CH3","(","CH2",")","10COOH",".","Derived","from","vegetable","sources","."),4384965). assertion_content_comment('tOboGo_LauroyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","lauroyl","(","dodecanoyl",")","group","from","one","compound","to","another","."),4248459). assertion_content_comment('tOboGo_LavandulylDiphosphateSynthaseActivity',s("Catalysis","of","the","reaction",":","2","dimethylallyl","diphosphate","=","diphosphate","+","lavandulyl","diphosphate","."),4343829). assertion_content_comment('tOboGo_LayerFormationInCerebralCortex',s("The","detachment","of","cells","from","radial","glial","fibers","at","the","appropriate","time","when","they","cease","to","migrate","and","form","distinct","layer","in","the","cerebral","cortex","."),4049978). assertion_content_comment('tOboGo_LBDDomainBinding',s("Interacting","selectively","and","non-covalently","with","the","LBD",",","the","ligand","binding","domain","found","in","nuclear","receptors",".","In","general",",","the","LBDs","consist","of","three","layers","comprised","of","twelve","alpha-helices","and","several","beta-strands","that","are","organized","around","a","lipophilic","ligand-binding","pocket","."),4277149). assertion_content_comment('tOboGo_LeadingEdgeCellDifferentiation',s("The","process","in","which","relatively","unspecialized","cells","acquire","specialized","structural","and/or","functional","features","of","leading","edge","cells",",","cells","at","the","front","of","a","migrating","epithelial","sheet","."),4019814). assertion_content_comment('tOboGo_LeadingEdgeCellFateCommitment',s("The","commitment","of","cells","to","leading","edge","cell","fate","and","their","capacity","to","differentiate","into","leading","edge","cells",".","Leading","edge","cells","are","found","at","the","front","of","a","migrating","epithelial","sheet","."),4019816). assertion_content_comment('tOboGo_LeadingEdgeCellFateDetermination',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","leading","edge","cell","regardless","of","its","environment",";","upon","determination",",","the","cell","fate","cannot","be","reversed","."),4019846). assertion_content_comment('tOboGo_LeadingEdgeMembrane',s("The","portion","of","the","plasma","membrane","surrounding","the","leading","edge","of","a","motile","cell","."),4051615). assertion_content_comment('tOboGo_LeadingStrandElongation',s("The","synthesis","of","DNA","from","a","template","strand","in","the","5","'","to","3","'","direction",";","leading","strand","elongation","is","continuous","as","it","proceeds","in","the","same","direction","as","the","replication","fork","."),4223778). assertion_content_comment('tOboGo_LeadIonBinding',s("Interacting","selectively","and","non-covalently","with","lead","(","Pb",")","ions","."),4337721). assertion_content_comment('tOboGo_LeadIonTransmembraneTransporterActivity',s("Catalysis","of","the","transfer","of","lead","(","Pb",")","ions","from","one","side","of","a","membrane","to","the","other","."),4252827). assertion_content_comment('tOboGo_LeadIonTransport',s("The","directed","movement","of","lead","(","Pb",")","ions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4289884). assertion_content_comment('tOboGo_LeadSulfideOxidation',s("The","chemical","reactions","and","pathways","resulting","in","the","conversion","of","lead","sulfide","to","lead","sulfate","."),4240040). assertion_content_comment('tOboGo_LeafAbscission',s("The","controlled","shedding","of","a","leaf","."),4156491). assertion_content_comment('tOboGo_LeafDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","leaf","over","time",",","from","its","formation","to","the","mature","structure","."),4031393). assertion_content_comment('tOboGo_LeafFormation',s("The","process","that","gives","rise","to","a","leaf",".","This","process","pertains","to","the","initial","formation","of","a","structure","from","unspecified","parts","."),4031405). assertion_content_comment('tOboGo_LeafletFormation',s("The","developmental","process","pertaining","to","the","initial","formation","of","a","leaflet","from","unspecified","parts",".","A","leaflet","is","one","of","the","ultimate","segments","of","a","compound","leaf","."),4149615). assertion_content_comment('tOboGo_LeafletMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","leaflet","are","generated","and","organized","."),4111256). assertion_content_comment('tOboGo_LeafMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","leaf","are","generated","and","organized","."),4031395). assertion_content_comment('tOboGo_LeafPapilla',s("A","plant","cell","papilla","that","is","part","of","a","leaf","papilla","cell","."),4155180). assertion_content_comment('tOboGo_LeafPhyllotacticPatterning',s("The","radial","pattern","formation","process","that","results","in","the","formation","of","leaf","primordia","around","the","center","of","a","shoot","apical","meristem","."),4161052). assertion_content_comment('tOboGo_LeafProximalDistalPatternFormation',s("The","regionalization","process","within","a","leaf","by","which","specific","areas","of","cell","differentiation","are","determined","along","a","proximal/distal","axis","."),4336328). assertion_content_comment('tOboGo_LeafSenescence',s("The","process","that","occurs","in","a","leaf","near","the","end","of","its","active","life","that","is","associated","with","the","dismantling","of","cell","components","and","membranes",",","loss","of","functional","chloroplasts",",","and","an","overall","decline","in","metabolism","."),4333978). assertion_content_comment('tOboGo_LeafShaping',s("The","developmental","process","that","pertains","to","the","organization","of","a","leaf","in","three-dimensional","space","once","the","structure","has","initially","formed","."),4031460). assertion_content_comment('tOboGo_LeafVascularTissuePatternFormation',s("Vascular","tissue","pattern","formation","as","it","occurs","in","the","leaf","of","vascular","plants","."),4332412). assertion_content_comment('tOboGo_LeakChannelActivity',s("Enables","the","transport","of","a","solute","across","a","membrane","via","a","narrow","pore","channel","that","is","open","even","in","an","unstimulated","or","'","resting","'","state","."),4332942). assertion_content_comment('tOboGo_LearningOrMemory',s("The","acquisition","and","processing","of","information","and/or","the","storage","and","retrieval","of","this","information","over","time","."),4150484). assertion_content_comment('tOboGo_Learning',s("Any","process","in","an","organism","in","which","a","relatively","long-lasting","adaptive","behavioral","change","occurs","as","the","result","of","experience","."),4150486). assertion_content_comment('tOboGo_Lectin',s("OBSOLETE",".","Lectins","are","proteins","obtained","particularly","from","the","seeds","of","leguminous","plants",",","but","also","from","many","other","plant","and","animal","sources",",","that","have","binding","sites","for","specific","mono","or","oligosaccharides","in","cell","walls","or","membranes",".","They","thereby","change","the","physiology","of","the","membrane","to","cause","agglutination",",","mitosis",",","or","other","biochemical","changes","in","the","cell","."),4218877). assertion_content_comment('tOboGo_LeftHornOfSinusVenosusDevelopment',s("The","progression","of","the","left","horn","of","the","sinus","venosus","from","its","initial","formation","to","the","mature","structure","."),4135223). assertion_content_comment('tOboGo_LeftLungDevelopment',s("The","biological","process","whose","specific","outcome","is","the","progression","of","a","left","lung","from","an","initial","condition","to","its","mature","state",".","This","process","begins","with","the","formation","of","the","left","lung","and","ends","with","the","mature","structure",".","The","left","lung","is","the","lung","which","is","on","the","left","side","of","the","anterior","posterior","axis","looking","from","a","dorsal","to","ventral","aspect","."),4117774). assertion_content_comment('tOboGo_LeftLungMorphogenesis',s("The","process","in","which","anatomical","structures","of","the","left","lung","are","generated","and","organized","."),4117785). assertion_content_comment('tOboGo_LeftRightAxisSpecification',s("The","establishment",",","maintenance","and","elaboration","of","the","left/right","axis",".","The","left/right","axis","is","defined","by","a","line","that","runs","orthogonal","to","both","the","anterior/posterior","and","dorsal/ventral","axes",".","Each","side","is","defined","from","the","viewpoint","of","the","organism","rather","of","the","observer","(","as","per","anatomical","axes",")"),4131532). assertion_content_comment('tOboGo_LeftRightPatternFormation',s("The","pattern","specification","process","that","results","in","the","subdivision","of","the","left/right","axis","in","space","to","define","an","area","or","volume","in","which","specific","patterns","of","cell","differentiation","will","take","place","or","in","which","cells","interpret","a","specific","environment","."),4112944). assertion_content_comment('tOboGo_LeftVentricularCardiacMuscleTissueMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","left","cardiac","ventricle","muscle","are","generated","and","organized","."),4194164). assertion_content_comment('tOboGo_LeftVentricularCompactMyocardiumMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","cardiac","left","ventricular","compact","myocardium","are","generated","and","organized","."),4194194). assertion_content_comment('tOboGo_LeftVentricularTrabecularMyocardiumMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","cardiac","left","ventricular","trabecular","myocardium","are","generated","and","organized","."),4194215). assertion_content_comment('tOboGo_LegDiscAnteriorPosteriorLineageRestriction',s("Formation","and/or","maintenance","of","a","lineage","boundary","between","anterior","and","posterior","compartments","of","the","leg","disc","that","cells","cannot","cross",",","thus","separating","the","populations","of","cells","in","each","compartment","."),4072306). assertion_content_comment('tOboGo_LegDiscAnteriorPosteriorPatternFormation',s("The","establishment",",","maintenance","and","elaboration","of","the","anterior/posterior","axis","of","the","leg","imaginal","disc","."),4072286). assertion_content_comment('tOboGo_LegDiscDevelopment',s("Progression","of","the","leg","imaginal","disc","over","time",",","from","its","initial","formation","through","to","its","metamorphosis","to","form","adult","structures","including","the","leg",",","coxa","and","ventral","thoracic","pleura","."),4018084). assertion_content_comment('tOboGo_LegDiscMorphogenesis',s("The","process","in","which","the","anatomical","structures","derived","from","the","leg","disc","are","generated","and","organized",".","This","includes","the","transformation","of","a","leg","imaginal","disc","from","a","monolayered","epithelium","in","the","larvae","of","holometabolous","insects","into","recognizable","adult","structures","including","the","leg",",","coxa","and","ventral","thoracic","pleura","."),4018094). assertion_content_comment('tOboGo_LegDiscPatternFormation',s("The","process","that","gives","rise","to","the","patterns","of","cell","differentiation","in","the","leg","imaginal","disc","."),4070879). assertion_content_comment('tOboGo_LegDiscProximalDistalPatternFormation',s("The","establishment",",","maintenance","and","elaboration","of","the","proximal/distal","axis","of","the","leg","imaginal","disc",",","a","precursor","to","the","adult","leg","."),4234404). 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assertion_content_comment('tOboGo_LensFiberCellDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","lens","fiber","cell","over","time",",","from","its","formation","to","the","mature","structure",".","Cell","development","does","not","include","the","steps","involved","in","committing","a","cell","to","a","lens","fiber","cell","fate",".","A","lens","fiber","cell","is","any","of","the","elongated",",","tightly","packed","cells","that","make","up","the","bulk","of","the","mature","lens","in","a","camera-type","eye","."),4137247). 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assertion_content_comment('tOboGo_LensFiberCellFateCommitment',s("The","process","in","which","the","developmental","fate","of","a","cell","becomes","restricted","such","that","it","will","develop","into","a","lens","fiber","cell",".","A","lens","fiber","cell","is","any","of","the","elongated",",","tightly","packed","cells","that","make","up","the","bulk","of","the","mature","lens","in","a","camera-type","eye","."),4137236). assertion_content_comment('tOboGo_LensFiberCellMorphogenesis',s("The","process","in","which","the","structures","of","a","lens","fiber","cell","are","generated","and","organized",".","This","process","occurs","while","the","initially","relatively","unspecialized","cell","is","acquiring","the","specialized","features","of","a","lens","fiber","cell",".","A","lens","fiber","cell","is","any","of","the","elongated",",","tightly","packed","cells","that","make","up","the","bulk","of","the","mature","lens","in","a","camera-type","eye","."),4137259). assertion_content_comment('tOboGo_Leptotene',s("A","cell","cycle","process","comprising","the","steps","by","which","a","cell","progresses","through","the","first","stage","of","prophase","I","in","meiosis",",","in","which","chromosomes","first","become","visible","."),3973672). assertion_content_comment('tOboGo_LeucineBinding',s("Interacting","selectively","and","non-covalently","with","2-amino-4-methylpentanoic","acid","."),4176633). assertion_content_comment('tOboGo_LeucineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","leucine",",","2-amino-4-methylpentanoic","acid","."),4257203). assertion_content_comment('tOboGo_LeucineCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","leucine",",","2-amino-4-methylpentanoic","acid","."),4231541). assertion_content_comment('tOboGo_LeucineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","L-leucine","+","H2O","+","NAD","+","=","4-methyl-2-oxopentanoate","+","NH3","+","NADH","."),4270157). assertion_content_comment('tOboGo_LeucineImport',s("The","directed","movement","of","leucine","into","a","cell","or","organelle","."),4115133). assertion_content_comment('tOboGo_LeucineIsoleucineValinePorterActivity',s("OBSOLETE",".","Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","nonpolar","amino","acid","(","out",")","=","ADP","+","phosphate","+","nonpolar","amino","acid","(","in",")"),4289767). assertion_content_comment('tOboGo_LeucineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","leucine",",","2-amino-4-methylpentanoic","acid","."),4231523). assertion_content_comment('tOboGo_LeucineTransport',s("The","directed","movement","of","leucine",",","2-amino-4-methylpentanoic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4115129). assertion_content_comment('tOboGo_LeucineValineIsoleucinePermeaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4296362). assertion_content_comment('tOboGo_LeucineZipperDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","leucine","zipper","domain",",","a","protein","secondary","structure","exhibiting","a","periodic","repetition","of","leucine","residues","at","every","seventh","position","over","a","distance","covering","eight","helical","turns","."),4324690). 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assertion_content_comment('tOboGo_LeucocyanidinOxygenaseActivity',s("Catalysis","of","the","reaction",":","leucocyanidin","+","2-oxoglutarate","+","O2","=","cis-","or","trans-dihydroquercetin","+","succinate","+","CO2","+","2","H2O","."),4268036). assertion_content_comment('tOboGo_LeucokininReceptorActivity',s("Combining","with","a","leucokinin",",","any","of","several","octapeptide","hormones","found","in","insects",",","to","initiate","a","change","in","cell","activity","."),4306515). assertion_content_comment('tOboGo_LeucophoreDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","the","specialized","features","of","a","leucophore","cell",".","Leucophores","are","pigment","cells","derived","from","the","neural","crest",".","They","contain","uric","acid","or","other","purine","crystals",",","deposited","in","stacks","called","leucosomes",".","This","gives","them","a","white","appearance","."),4104981). assertion_content_comment('tOboGo_LeucoplastFission',s("The","creation","of","two","or","more","leucoplasts","by","division","of","one","leucoplast",".","A","leucoplast","is","a","colorless","plastid","involved","in","the","synthesis","of","monoterpenes","."),4325683). assertion_content_comment('tOboGo_LeucoplastOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","leucoplast",".","A","leucoplast","is","a","colorless","plastid","involved","in","the","synthesis","of","monoterpenes","."),4261037). assertion_content_comment('tOboGo_Leucoplast',s("A","colorless","plastid","involved","in","the","synthesis","of","monoterpenes","."),4023005). assertion_content_comment('tOboGo_LeucoplastStroma',s("The","space","enclosed","by","the","double","membrane","of","a","leucoplast","."),4023015). assertion_content_comment('tOboGo_Leucosome',s("A","tissue-specific",",","membrane-bounded","cytoplasmic","organelle","within","which","uric","acid","and/or","purines","crystalize","in","reflective","stacks",".","Leucosomes","are","synthesized","in","leucophore","cells","and","have","a","whitish","cast","."),4326351). assertion_content_comment('tOboGo_LeucylAminopeptidaseActivity',s("OBSOLETE",".","Catalysis","of","the","release","of","an","N-terminal","amino","acid",",","Xaa-Xbb-",",","in","which","Xaa","is","preferably","Leu",",","but","may","be","other","amino","acids","including","Pro","although","not","Arg","or","Lys",",","and","Xbb","may","be","Pro","."),4210863). assertion_content_comment('tOboGo_LeucyltransferaseActivity',s("Catalysis","of","the","reaction",":","L-leucyl-tRNA","+","protein","=","tRNA","+","L-leucyl-protein","."),4248470). assertion_content_comment('tOboGo_LeukemiaInhibitoryFactorReceptorActivity',s("Combining","with","leukemia","inhibitory","factor","to","initiate","a","change","in","cell","activity","."),4198809). assertion_content_comment('tOboGo_LeukemiaInhibitoryFactorReceptorBinding',s("Interacting","selectively","and","non-covalently","with","the","leukemia","inhibitory","factor","receptor","."),4214447). assertion_content_comment('tOboGo_LeukemiaInhibitoryFactorSignalingPathwayInvolvedInForebrainNeuronFateCommitment',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","leukemia","inhibitory","factor","receptor","binding","to","one","of","its","physiological","ligands","that","contributes","to","the","commitment","of","a","neuroblast","to","a","neuronal","fate",".","The","neuron","will","reside","in","the","forebrain","."),4053416). assertion_content_comment('tOboGo_LeukemiaInhibitoryFactorSignalingPathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","leukemia","inhibitory","factor","receptor","binding","to","one","of","its","physiological","ligands","."),4053412). assertion_content_comment('tOboGo_LeukocyteActivationInvolvedInImmuneResponse',s("A","change","in","morphology","and","behavior","of","a","leukocyte","resulting","from","exposure","to","a","specific","antigen",",","mitogen",",","cytokine",",","cellular","ligand",",","or","soluble","factor",",","leading","to","the","initiation","or","perpetuation","of","an","immune","response","."),3992417). assertion_content_comment('tOboGo_LeukocyteActivationInvolvedInInflammatoryResponse',s("A","change","in","the","morphology","or","behavior","of","a","leukocyte","resulting","from","exposure","to","an","activating","factor","such","as","a","cellular","or","soluble","ligand",",","leading","to","the","initiation","or","perpetuation","of","an","inflammatory","response","."),3992340). assertion_content_comment('tOboGo_LeukocyteActivation',s("A","change","in","morphology","and","behavior","of","a","leukocyte","resulting","from","exposure","to","a","specific","antigen",",","mitogen",",","cytokine",",","cellular","ligand",",","or","soluble","factor","."),3984560). assertion_content_comment('tOboGo_LeukocyteAdhesiveActivation',s("The","activation","of","loosely","bound","or","rolling","leukocytes","by","signals","displayed","on","blood","vessel","endothelial","cells",",","which","is","typically","the","second","step","in","cellular","extravasation","."),4100917). assertion_content_comment('tOboGo_LeukocyteAggregation',s("The","adhesion","of","one","leukocyte","to","one","or","more","other","leukocytes","via","adhesion","molecules","."),4141702). assertion_content_comment('tOboGo_LeukocyteApoptosis',s("The","process","of","apoptosis","in","a","leukocyte","."),3993758). assertion_content_comment('tOboGo_LeukocyteChemotaxisInvolvedInImmuneResponse',s("The","movement","of","an","immune","cell","in","response","to","an","external","stimulus","a","part","of","an","immune","response","."),4377367). assertion_content_comment('tOboGo_LeukocyteChemotaxisInvolvedInInflammatoryResponse',s("The","movement","of","an","immune","cell","in","response","to","an","external","stimulus","contributing","to","an","inflammatory","response","."),4377389). assertion_content_comment('tOboGo_LeukocyteChemotaxis',s("The","movement","of","a","leukocyte","in","response","to","an","external","stimulus","."),3997946). assertion_content_comment('tOboGo_LeukocyteDegranulation',s("The","regulated","exocytosis","of","secretory","granules","by","a","leukocyte","."),3996373). assertion_content_comment('tOboGo_LeukocyteDifferentiation',s("The","process","in","which","a","relatively","unspecialized","hemopoietic","precursor","cell","acquires","the","specialized","features","of","a","leukocyte",".","A","leukocyte","is","an","achromatic","cell","of","the","myeloid","or","lymphoid","lineages","capable","of","ameboid","movement",",","found","in","blood","or","other","tissue","."),3988991). assertion_content_comment('tOboGo_LeukocyteHomeostasis',s("The","process","of","regulating","the","proliferation","and","elimination","of","cells","of","the","immune","system","such","that","the","total","number","of","cells","of","a","particular","cell","type","within","a","whole","or","part","of","an","organism","is","stable","over","time","in","the","absence","of","an","outside","stimulus","."),3984798). assertion_content_comment('tOboGo_LeukocyteMediatedCytotoxicity',s("The","directed","killing","of","a","target","cell","by","a","leukocyte","."),3983005). assertion_content_comment('tOboGo_LeukocyteMediatedImmunity',s("Any","process","involved","in","the","carrying","out","of","an","immune","response","by","a","leukocyte","."),3982814). assertion_content_comment('tOboGo_LeukocyteMigrationInvolvedInImmuneResponse',s("The","movement","of","a","leukocyte","within","or","between","different","tissues","and","organs","of","the","body","as","part","of","an","immune","response","."),3995983). assertion_content_comment('tOboGo_LeukocyteMigrationInvolvedInInflammatoryResponse',s("The","movement","of","a","leukocyte","within","or","between","different","tissues","and","organs","of","the","body","contributing","to","an","inflammatory","response","."),3995966). assertion_content_comment('tOboGo_LeukocyteMigration',s("The","movement","of","a","leukocyte","within","or","between","different","tissues","and","organs","of","the","body","."),3995958). assertion_content_comment('tOboGo_LeukocyteProliferation',s("The","expansion","of","a","leukocyte","population","by","cell","division","."),3984845). assertion_content_comment('tOboGo_LeukocyteTetheringOrRolling',s("Transient","adhesive","interactions","between","leukocytes","and","endothelial","cells","lining","blood","vessels","mediated","primarily","by","selectins","and","which","are","typically","the","first","step","in","cellular","extravasation","."),4100897). assertion_content_comment('tOboGo_LeukotrieneB4ReceptorActivity',s("Combining","with","leukotriene","B4",",","LTB4",",","to","initiate","a","change","in","cell","activity",".","Leukotriene","B4","is","also","known","as","(","6Z",",","8E",",","10E",",","14Z",")","-","(","5S",",","12R",")","-5",",","12-dihydroxyicosa-6",",","8",",","10",",","14-tetraen-1-oate","."),4383897). assertion_content_comment('tOboGo_LeukotrieneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","leukotriene",",","a","pharmacologically","active","substance","derived","from","a","polyunsaturated","fatty","acid",",","such","as","arachidonic","acid","."),4239973). assertion_content_comment('tOboGo_LeukotrieneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","leukotriene",",","a","pharmacologically","active","substance","derived","from","a","polyunsaturated","fatty","acid",",","such","as","arachidonic","acid","."),4231036). assertion_content_comment('tOboGo_LeukotrieneProductionInvolvedInInflammatoryResponse',s("The","synthesis","or","release","of","any","leukotriene","following","a","stimulus","as","part","of","an","inflammatory","response",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4084354). assertion_content_comment('tOboGo_LeukotrieneReceptorActivity',s("Combining","with","a","leukotriene","to","initiate","a","change","in","cell","activity",".","Leukotrienes","are","pharmacologically","active","substances","with","a","set","of","three","conjugated","double","bonds",";","some","contain","a","peptide","group","based","on","cysteine","."),4197992). assertion_content_comment('tOboGo_LeukotrieneReceptorBinding',s("Interacting","selectively","and","non-covalently","with","a","leukotriene","receptor","."),4322836). assertion_content_comment('tOboGo_LeukotrieneTransport',s("The","directed","movement","of","leukotrienes","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Leukotrienes","are","linear","C20","endogenous","metabolites","of","arachidonic","acid","(","icosa-5",",","8",",","11",",","14-tetraenoic","acid",")","containing","a","terminal","carboxy","function","and","four","or","more","double","bonds","(","three","or","more","of","which","are","conjugated",")","as","well","as","other","functional","groups","."),4170082). assertion_content_comment('tOboGo_LevanaseActivity',s("Catalysis","of","the","random","hydrolysis","of","2",",","6-beta-D-fructofuranosidic","linkages","in","2",",","6-beta-D-fructans","(","levans",")","containing","more","than","3","fructose","units","."),4319968). assertion_content_comment('tOboGo_LevansucraseActivity',s("Catalysis","of","the","reaction",":","sucrose","+","2",",","6-beta-D-fructosyl","(","n",")","=","glucose","+","2",",","6-beta-D-fructosyl","(","n","+","1",")"),4270130). assertion_content_comment('tOboGo_LevopimaradieneSynthaseActivity',s("Catalysis","of","the","reaction",":","(","+",")","-copalyl","diphosphate","=","abieta-8","(","14",")",",","12-diene","+","diphosphate","."),4191330). assertion_content_comment('tOboGo_LewisAEpitopeBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","Lewis","a","epitope",",","a","trisaccharide","(","Fuc-alpha-1-","&","gt",";","4","(","Gal-beta-1-","&","gt",";","3",")","GlcNAc",")","characteristic","of","plant","protein","N-linked","oligosaccharides","."),4332792). assertion_content_comment('tOboGo_LeydigCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","structural","and/or","functional","features","of","a","Leydig","cell",".","A","Leydig","cell","is","a","testosterone-secreting","cell","in","the","interstitial","area",",","between","the","seminiferous","tubules",",","in","the","testis","."),4063092). assertion_content_comment('tOboGo_LicheninaseActivity',s("Catalysis","of","the","hydrolysis","of","1",",","4-beta-D-glucosidic","linkages","in","beta-D-glucans","containing","1",",","3-","and","1",",","4-bonds","."),4316156). assertion_content_comment('tOboGo_LicodioneSynthaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","liquiritigenin","+","NADPH","+","O","(","2",")","=","H","(","2",")","O","+","licodione","+","NADP","(","+",")"),4342231). assertion_content_comment('tOboGo_Lid2Complex',s("A","protein","complex","that","is","thought","to","be","involved","in","regulation","of","chromatin","remodeling",".","In","Schizosaccharomyces","the","complex","contains","Lid1p",",","Ash2p",",","Ecm5p",",","Snt2p",",","and","Sdc1p","."),4384977). assertion_content_comment('tOboGo_LifelongOtolithMineralization',s("The","formation","and","growth","of","otoliths","throughout","the","life","of","the","organism",".","Otoliths","are","the","large","extracellular","ear-stones","of","the","fish","inner","ear",",","produced","by","precipitation","of","specific","crystal","forms","of","calcium","carbonate","on","organic","matrices",".","The","otolith","enlarges","throughout","the","life","of","the","fish",",","as","layers","of","calcium","carbonate","are","added","."),4319058). assertion_content_comment('tOboGo_LigandBindingToTCellReceptor',s("Binding","of","a","diffusible","ligand","to","a","T","cell","receptor","as","part","of","a","signaling","process","."),4346797). assertion_content_comment('tOboGo_LigaseActivityFormingPhosphoricEsterBonds',s("Catalysis","of","the","joining","of","two","molecules",",","or","two","groups","within","a","single","molecule",",","via","a","phosphoric","ester","bond",",","with","the","concomitant","hydrolysis","of","the","diphosphate","bond","in","ATP","or","a","similar","triphosphate","."),4183898). assertion_content_comment('tOboGo_LigaseActivity',s("Catalysis","of","the","joining","of","two","substances",",","or","two","groups","within","a","single","molecule",",","with","the","concomitant","hydrolysis","of","the","diphosphate","bond","in","ATP","or","a","similar","triphosphate","."),4155380). assertion_content_comment('tOboGo_LigaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","ligase","."),4222186). assertion_content_comment('tOboGo_LigaseRegulatorActivity',s("Modulates","the","activity","of","a","ligase","."),4074097). assertion_content_comment('tOboGo_LightAbsorption',s("The","reception","of","a","photon","by","a","cell","."),4033844). assertion_content_comment('tOboGo_LightTransducerActivity',s("Absorbing","energy","from","one","or","more","photons","and","transferring","their","energy","to","another","molecule",",","usually","a","protein",",","within","the","cell","."),4320617). 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assertion_content_comment('tOboGo_LigninCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lignins",",","a","class","of","polymers","of","phenylpropanoid","units","."),4353401). assertion_content_comment('tOboGo_LigninMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lignins",",","a","class","of","polymers","of","phenylpropanoid","units","."),4262494). assertion_content_comment('tOboGo_LigninNetwork',s("An","extracellular","matrix","part","that","consists","of","lignin","in","the","form","of","a","three-dimensional","polymeric","network",".","Lignins","are","complex","racemic","aromatic","heteropolymers","derived","from","a","variety","of","phenylpropane","monomers","coupled","together","by","an","assortment","of","carbon-carbon","and","ether","linkages",".","Lignin","is","crucial","for","structural","integrity","of","the","cell","wall","and","stiffness","and","strength","of","the","stem",".","In","addition",",","lignin","waterproofs","the","cell","wall",",","enabling","transport","of","water","and","solutes","through","the","vascular","system",",","and","plays","a","role","in","protecting","plants","against","pathogens","."),4103938). assertion_content_comment('tOboGo_LimbBasalEpidermalCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","limb","epidermal","basal","cell",".","A","epidermal","basal","cell","cell","is","a","cell","that","retains","the","ability","to","divide","and","proliferate","throughout","life","to","provide","progenitor","cells","that","can","differentiate","into","more","specialized","cell","of","the","limb","epidermis","."),4114070). assertion_content_comment('tOboGo_LimbBasalEpidermalCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","limb","basal","epidermal","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4114101). assertion_content_comment('tOboGo_LimbBudFormation',s("The","process","pertaining","to","the","initial","formation","of","a","limb","bud","from","unspecified","parts",".","This","process","begins","with","the","formation","of","a","local","condensation","of","mesenchyme","cells","within","the","prospective","limb","field",",","and","ends","when","a","limb","bud","is","recognizable","."),4071264). assertion_content_comment('tOboGo_LimbDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","limb","over","time",",","from","its","formation","to","the","mature","structure",".","A","limb","is","an","appendage","of","an","animal","used","for","locomotion","or","grasping",".","Examples","include","legs",",","arms","or","some","types","of","fin","."),4018137). assertion_content_comment('tOboGo_LimbEpidermisDevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","epidermis","of","the","limb","over","time",",","from","its","formation","to","the","mature","structure",".","The","limb","epidermis","is","the","outer","epithelial","layer","of","the","limb",",","it","is","a","complex","stratified","squamous","epithelium","."),4114059). assertion_content_comment('tOboGo_LimbEpidermisStratification',s("The","pattern","specification","process","that","results","in","the","subdivision","of","the","epidermis","of","the","limb","in","space","to","define","a","volume","in","which","specific","patterns","of","basal","cell",",","spinous","cell","and","granular","cells","will","differentiate","giving","rise","to","the","layers","of","the","limb","epidermis","."),4114090). assertion_content_comment('tOboGo_LimbGranularCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","limb","epidermal","granular","cell","."),4114111). assertion_content_comment('tOboGo_LimbGranularCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","an","limb","granular","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4114122). assertion_content_comment('tOboGo_LimbicSystemDevelopment',s("The","progression","of","the","limbic","system","over","time","from","its","initial","formation","until","its","mature","state",".","The","limbic","system","is","a","collection","of","structures","in","the","brain","involved","in","emotion",",","motivation","and","emotional","aspects","of","memory","."),4041141). assertion_content_comment('tOboGo_LimbMorphogenesis',s("The","process","in","which","the","anatomical","structures","of","a","limb","are","generated","and","organized",".","A","limb","is","an","appendage","of","an","animal","used","for","locomotion","or","grasping",".","Examples","include","legs",",","arms","or","some","types","of","fin","."),4018140). assertion_content_comment('tOboGo_LimbSpinousCellDifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","features","of","a","limb","epidermal","spinous","cell","."),4114080). assertion_content_comment('tOboGo_LimbSpinousCellFateSpecification',s("The","process","in","which","a","cell","becomes","capable","of","differentiating","autonomously","into","a","limb","spinous","cell","in","an","environment","that","is","neutral","with","respect","to","the","developmental","pathway",";","upon","specification",",","the","cell","fate","can","be","reversed","."),4114133). assertion_content_comment('tOboGo_LIMDomainBinding',s("Interacting","selectively","and","non-covalently","with","a","LIM","domain","(","for","Lin-11","Isl-1","Mec-3",")","of","a","protein",",","a","domain","with","seven","conserved","cysteine","residues","and","a","histidine",",","that","binds","two","zinc","ions","and","acts","as","an","interface","for","protein-protein","interactions","."),4311968). assertion_content_comment('tOboGo_LimitDextrinaseActivity',s("Catalysis","of","the","hydrolysis","of","(","1",",","6",")","-alpha-D-glucosidic","linkages","in","alpha-","and","beta-limit","dextrins","of","amylopectin","and","glycogen",",","and","in","amylopectin","and","pullulan","."),4332421). assertion_content_comment('tOboGo_LimoneneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","limonene","(","4-isopropenyl-1-methyl-cyclohexene",")",",","a","monocyclic","monoterpene","."),4353641). assertion_content_comment('tOboGo_LimoneneCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","limonene","(","4-isopropenyl-1-methyl-cyclohexene",")",",","a","monocyclic","monoterpene","."),4353656). assertion_content_comment('tOboGo_LimoneneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","limonene","(","4-isopropenyl-1-methyl-cyclohexene",")",",","a","monocyclic","monoterpene","."),4272100). assertion_content_comment('tOboGo_LimoneneMonooxygenaseActivity',s("Catalysis","of","a","monooxygenase","reaction","in","which","oxygen","is","incorporated","into","limonene","."),4191026). assertion_content_comment('tOboGo_LimonoidGlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","limonin","=","glucosyl-limonin","+","UDP","."),4277667). assertion_content_comment('tOboGo_LinamarinSynthaseActivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","2-hydroxy-2-methylpropanenitrile","=","UDP","+","linamarin","."),4270780). assertion_content_comment('tOboGo_LinearElementAssembly',s("The","cell","cycle","process","in","which","a","proteinaceous","scaffold",",","related","to","the","synaptonemal","complex",",","is","assembled","in","association","with","S",".","pombe","chromosomes","during","meiotic","prophase","."),4061141). assertion_content_comment('tOboGo_LinearElement',s("A","proteinaceous","scaffold","associated","with","S",".","pombe","chromosomes","during","meiotic","prophase",".","Linear","elements","have","a","structure","related","to","but","not","equivalent","to","the","synaptonemal","complex","."),4061192). assertion_content_comment('tOboGo_LinearVestibuloocularReflex',s("A","vestibular","reflex","by","which","a","response","to","a","linear","acceleration","stimulus","begins","with","an","afferent","nerve","impulse","from","a","receptor","in","the","otolith","and","ends","with","the","compensatory","action","of","eye","muscles",".","Signaling","never","reaches","a","level","of","consciousness","."),4159643). assertion_content_comment('tOboGo_LinoleateDiolSynthaseActivity',s("Catalysis","of","the","reaction",":","linoleate","+","O2","=","(","9Z",",","12Z",")","-","(","7S",",","8S",")","-dihydroxyoctadeca-9",",","12-dienoate","."),4342828). assertion_content_comment('tOboGo_LinoleateIsomeraseActivity',s("Catalysis","of","the","reaction",":","linoleate","=","9-cis",",","11-trans-octadecadienoate","."),4270796). assertion_content_comment('tOboGo_LinoleicAcidBinding',s("Interacting","selectively","and","non-covalently","with","linoleic","acid",",","the","18-carbon","unsaturated","fatty","acid","(","9Z",",","12Z",")","-octadeca-9",",","12-dienoic","acid","."),4174490). assertion_content_comment('tOboGo_LinoleicAcidEpoxygenaseActivity',s("Catalysis","of","an","NADPH-","and","oxygen-dependent","reaction","that","converts","linoleic","acid","to","a","cis-epoxyoctadecenoic","acid","."),4172686). assertion_content_comment('tOboGo_LinoleicAcidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","linoleic","acid",",","an","unsaturated","omega-6","fatty","acid","that","has","the","molecular","formula","C18H32O2","."),4326459). assertion_content_comment('tOboGo_LipaseActivatorActivity',s("Increases","the","activity","of","a","lipase",",","an","enzyme","that","catalyzes","of","the","hydrolysis","of","a","lipid","."),4160038). assertion_content_comment('tOboGo_LipaseActivity',s("Catalysis","of","the","hydrolysis","of","a","lipid","or","phospholipid","."),4174183). assertion_content_comment('tOboGo_LipaseBinding',s("Interacting","selectively","and","non-covalently","with","any","lipase","."),4376775). assertion_content_comment('tOboGo_LipaseInhibitorActivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","lipase",",","an","enzyme","that","catalyzes","of","the","hydrolysis","of","a","lipid","."),4156716). assertion_content_comment('tOboGo_LipidABiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lipid","A",",","the","glycolipid","group","of","bacterial","lipopolysaccharides",",","consisting","of","six","fatty","acyl","chains","linked","to","two","glucosamine","residues","."),4024066). assertion_content_comment('tOboGo_LipidAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lipid","A",",","the","glycolipid","group","of","bacterial","lipopolysaccharides",",","consisting","of","six","fatty","acyl","chains","linked","to","two","glucosamine","residues","."),4024062). assertion_content_comment('tOboGo_LipidAntigenAssemblyWithMHCClassIbProteinComplex',s("The","binding","of","a","lipid","antigen","to","the","antigen","binding","groove","of","an","MHC","class","Ib","protein","complex",".","Class","Ib","here","refers","to","non-classical","class","I","molecules",",","such","as","those","of","the","CD1","gene","family","."),3993983). assertion_content_comment('tOboGo_LipidAntigenBinding',s("Interacting","selectively","and","non-covalently","with","a","lipid","antigen","."),4307110). assertion_content_comment('tOboGo_LipidAntigenTransport',s("The","directed","movement","of","a","lipid","antigen","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),3993880). assertion_content_comment('tOboGo_LipidAPhosphateMethyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosylmethionine","(","SAM",")","to","the","1-phosphate","group","of","lipid","A","."),4327372). assertion_content_comment('tOboGo_LipidBinding',s("Interacting","selectively","and","non-covalently","with","a","lipid","."),4071630). assertion_content_comment('tOboGo_LipidBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","lipids",",","compounds","soluble","in","an","organic","solvent","but","not",",","or","sparingly",",","in","an","aqueous","solvent","."),4009936). assertion_content_comment('tOboGo_LipidCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","lipids",",","compounds","soluble","in","an","organic","solvent","but","not",",","or","sparingly",",","in","an","aqueous","solvent","."),4037665). assertion_content_comment('tOboGo_LipidDigestion',s("The","whole","of","the","physical",",","chemical",",","and","biochemical","processes","carried","out","by","living","organisms","to","break","down","ingested","lipids","into","components","that","may","be","easily","absorbed","and","directed","into","metabolism","."),4048335). assertion_content_comment('tOboGo_LipidGlycosylation',s("Covalent","attachment","of","a","glycosyl","residue","to","a","lipid","molecule","."),4312052). assertion_content_comment('tOboGo_LipidHomeostasis',s("Any","process","involved","in","the","maintenance","of","an","internal","steady","state","of","lipid","within","an","organism","or","cell","."),4141353). assertion_content_comment('tOboGo_LipidKinaseActivity',s("Catalysis","of","the","phosphorylation","of","a","simple","or","complex","lipid","."),4206456). assertion_content_comment('tOboGo_LipidLocalization',s("Any","process","in","which","a","lipid","is","transported","to",",","or","maintained","in",",","a","specific","location","."),3993874). assertion_content_comment('tOboGo_LipidMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","lipids",",","compounds","soluble","in","an","organic","solvent","but","not",",","or","sparingly",",","in","an","aqueous","solvent",".","Includes","fatty","acids",";","neutral","fats",",","other","fatty-acid","esters",",","and","soaps",";","long-chain","(","fatty",")","alcohols","and","waxes",";","sphingoids","and","other","long-chain","bases",";","glycolipids",",","phospholipids","and","sphingolipids",";","and","carotenes",",","polyprenols",",","sterols",",","terpenes","and","other","isoprenoids","."),4009916). assertion_content_comment('tOboGo_LipidModification',s("The","covalent","alteration","of","one","or","more","fatty","acids","in","a","lipid",",","resulting","in","a","change","in","the","properties","of","the","lipid","."),4037125). assertion_content_comment('tOboGo_LipidOxidation',s("The","removal","of","one","or","more","electrons","from","a","lipid",",","with","or","without","the","concomitant","removal","of","a","proton","or","protons",",","by","reaction","with","an","electron-accepting","substance",",","by","addition","of","oxygen","or","by","removal","of","hydrogen","."),4057944). assertion_content_comment('tOboGo_LipidParticleOrganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","lipid","particle","."),4357101).