:- include('dir.header'). assertion_content_comment('oboGo_Number111_Trichloro_22_Bis_4_ChlorophenylEthaneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","1",",","1",",","1-trichloro-2",",","2-bis-","(","4-chlorophenyl",")","ethane","(","DDT",")",",","a","chlorinated","broad","spectrum","contact","insecticide","."),4045256). assertion_content_comment('oboGo_Number111Trichloroethanereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","1",",","1",",","1-trichloroethane","+","2","H","+","+","2","e-","=","1",",","1-dichloroethane","+","HCl","."),4276697). assertion_content_comment('oboGo_Number112Trichloroethenereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","trichloroethene","+","2","H","+","+","2","e-","=","HCl","+","1",",","2-dichloroethene","."),4277010). assertion_content_comment('oboGo_Number11_Beta_HydroxysteroidDehydrogenaseNADActivity_4',s("OBSOLETE",".","Catalysis","of","the","reaction",":","an","11-beta-hydroxysteroid","+","NAD","+","=","an","11-oxosteroid","+","NADH","+","H","+"),4338004). assertion_content_comment('oboGo_Number11BetaHydroxysteroiddehydrogenasenadactivity',s("Catalysis","of","the","reaction",":","an","11-beta-hydroxysteroid","+","NAD","+","=","an","11-oxosteroid","+","NADH","+","H","+"),4175030). assertion_content_comment('oboGo_Number11_Beta_HydroxysteroidDehydrogenaseNADPActivity_4',s("OBSOLETE",".","Catalysis","of","the","reaction",":","an","11-beta-hydroxysteroid","+","NADP","+","=","an","11-oxosteroid","+","NADPH","+","H","+"),4338014). assertion_content_comment('oboGo_Number11_Beta_HydroxysteroidDehydrogenaseNADPActivity_6',s("Catalysis","of","the","reaction",":","an","11-beta-hydroxysteroid","+","NAD","(","P",")","+","=","an","11-oxosteroid","+","NAD","(","P",")","H","+","H","+"),4188551). assertion_content_comment('oboGo_Number11BetaHydroxysteroiddehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","an","11-beta-hydroxysteroid","+","NADP","+","=","an","11-oxosteroid","+","NADPH","+","H","+"),4175039). assertion_content_comment('oboGo_Number11Cisretinalbinding',s("Interacting","selectively","and","non-covalently","with","11-cis","retinal",",","an","isomer","of","retinal","that","plays","an","important","role","in","the","visual","process","in","most","vertebrates",".","11-cis","retinal","combines","with","opsin","in","the","rods","(","scotopsin",")","to","form","rhodopsin","or","visual","purple",".","Retinal","is","one","of","the","three","compounds","that","makes","up","vitamin","A","."),4219064). assertion_content_comment('oboGo_Number11CisRetinylPalmitatehydrolaseactivity',s("Catalysis","of","the","reaction",":","11-cis-retinyl","palmitate","+","H","(","2",")","O","=","11-cis-retinol","+","H","(","+",")","+","palmitate","."),4371515). assertion_content_comment('oboGo_Number11_Dichloro_22_Bis4_ChlorophenylEthaneDehydrochlorinaseActivity',s("Catalysis","of","the","reaction",":","1",",","1-dichloro-2",",","2-bis","(","4-chlorophenyl",")","ethane","=","HCl","+","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethene",".","1",",","1-dichloro-2",",","2-bis","(","4-chlorophenyl",")","ethane","is","also","known","as","DDD",";","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethene","is","also","known","as","DDMU","."),4273465). assertion_content_comment('oboGo_Number11_Dichloro_22_Bis4_ChlorophenylEtheneDehalogenaseActivity',s("Catalysis","of","the","reaction",":","1",",","1-dichloro-2",",","2-bis","(","4-chlorophenyl",")","ethene","+","H","+","+","2","e-","=","Cl-","+","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethene",".","1",",","1-dichloro-2",",","2-bis","(","4-chlorophenyl",")","ethene","is","also","known","as","DDE",";","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethene","is","also","known","as","DDMU","."),4275356). assertion_content_comment('oboGo_Number11_Dichloro_2_Dihydroxy_4_Chlorophenyl_4_ChlorophenylEthene12_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","1",",","1-dichloro-2-","(","dihydroxy-4","'","-chorophenyl",")","-2-","(","4-chlorophenyl",")","ethene","+","O2","=","6-oxo-2-hydroxy-7-","(","4-chlorophenyl",")","-3",",","8",",","8-trichloroocta-2E",",","4E",",","7-trienoate","."),4278891). assertion_content_comment('oboGo_Number11Dichloroethanereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","1",",","1-dichloroethane","+","2","H","+","+","2","e-","=","chloroethane","+","HCl","."),4348768). assertion_content_comment('oboGo_Number11_O_Demethyl_17_O_DeacetylvindolineO_MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","11-O-demethyl-17-O-deacetylvindoline","=","S-adenosyl-L-homocysteine","+","17-O-deacetylvindoline","."),4308431). assertion_content_comment('oboGo_Number123Tribromopropanemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","1",",","2",",","3-tribromopropane",",","a","toxic","and","volatile","organic","compound","commonly","used","as","a","nematocide","in","agriculture","."),4272537). assertion_content_comment('oboGo_Number124Trichlorobenzenemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","1",",","2",",","4-trichlorobenzene",",","a","derivative","of","benzene","with","chlorine","atoms","attached","to","positions","1",",","2","and","4","of","the","ring",".","It","is","a","colorless","liquid","used","as","a","solvent","in","chemical","manufacturing",",","in","dyes","and","intermediates",",","dielectric","fluid",",","synthetic","transformer","oils",",","lubricants",",","heat-transfer","medium","and","insecticides","."),4272379). assertion_content_comment('oboGo_Number12AlphaLFucosidaseactivity',s("Catalysis","of","the","reaction",":","H2O","+","methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside","=","L-fucose","+","methyl","beta-D-galactoside","."),4371669). assertion_content_comment('oboGo_Number12BetaFructan1fFructosyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","1",",","2-beta-D-fructosyl",")","(","n",")","+","(","1",",","2-beta-D-fructosyl",")","(","m",")","=","(","1",",","2-beta-D-fructosyl",")","(","n","+","1",")","+","(","1",",","2-beta-D-fructosyl",")","(","m-1",")"),4367792). assertion_content_comment('oboGo_Number12_Bis4_Hydroxyphenyl_2_ProponolDehydrataseActivity',s("Catalysis","of","the","reaction",":","1",",","2-bis","(","4-hydroxyphenyl",")","-2-propanol","=","4",",","4","'","-dihydroxy-alpha-methylstilbene","+","H2O","."),4352552). assertion_content_comment('oboGo_Number12Dehydroreticuliniumreductasenadphactivity',s("Catalysis","of","the","reaction",":","(","R",")","-reticuline","+","NADP","(","+",")","=","1",",","2-dehydroreticuline","+","H","(","+",")","+","NADPH","."),4365744). assertion_content_comment('oboGo_Number12Diacylglycerol3BetaGalactosyltransferaseactivity',s("Catalysis","of","the","reaction",":","1",",","2-diacyl-sn-glycerol","+","UDP-D-galactose","=","1",",","2-diacyl-3-beta-D-galactosyl-sn-glycerol","+","H","(","+",")","+","UDP","."),4359322). assertion_content_comment('oboGo_Number12Diacylglycerol3Glucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","1",",","2-diacylglycerol","+","UDP-D-glucose","=","3-D-glucosyl-1",",","2-diacylglycerol","+","UDP","."),4366558). assertion_content_comment('oboGo_Number12_Diacyl_Sn_Glycero_3_PhosphocholineMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","any","1",",","2-diacyl-sn-glycero-3-phosphocholine",",","the","compounds","most","commonly","designated","lecithin","."),4230607). assertion_content_comment('oboGo_Number12Dichloroethanecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","1",",","2-dichloroethane",",","a","major","commodity","chemical","used",",","for","example",",","in","the","manufacture","of","vinyl","chloride","."),4238306). assertion_content_comment('oboGo_Number12Dichloroethanemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","1",",","2-dichloroethane",",","a","major","commodity","chemical","used",",","for","example",",","in","the","manufacture","of","vinyl","chloride","."),4238274). assertion_content_comment('oboGo_Number12Dichloroethenereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","1",",","2-dichloroethene","+","2","H","+","+","2","e-","=","HCl","+","vinyl","chloride","."),4275311). assertion_content_comment('oboGo_Number12Dihydrovomileninereductaseactivity',s("Catalysis","of","the","reaction",":","17-O-acetylnorajmaline","+","NADP","(","+",")","=","1",",","2-dihydrovomilenine","+","H","(","+",")","+","NADPH","."),4277992). assertion_content_comment('oboGo_Number12_Dihydroxy_125678_HexyhadronaphthaleneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","cis-1",",","2-dihydroxy-1",",","2",",","5",",","6",",","7",",","8-hexahydronaphthalene","+","NAD","+","=","1",",","2-dihydroxy-5",",","6",",","7",",","8-tetrahydronaphthalene","+","NADH","+","H","+"),4350529). assertion_content_comment('oboGo_Number12_Dihydroxy_5678_TetrahydronaphthaleneExtradiolDioxygenaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxy-5",",","6",",","7",",","8-tetrahydronaphthalene","+","O2","=","4-","(","2-oxocyclohexyl",")","-2-hydroxy-buta-2",",","4-dienoate","+","H","+"),4350538). assertion_content_comment('oboGo_Number12_Dihydroxy_6_Methylcyclohexa_35_DienecarboxylateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","1",",","6-dihydroxy-2-methylcyclohexa-2",",","4-dienecarboxylate","+","NAD","(","+",")","=","3-methylcatechol","+","CO","(","2",")","+","NADH","."),4278350). assertion_content_comment('oboGo_Number12_Dihydroxy_7_HydroxymethylnaphthaleneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxy-7-hydroxymethylnaphthalene","+","O2","=","2-hydroxy-7-hydroxymethylchromene-2-carboxylate","."),4352174). assertion_content_comment('oboGo_Number12_Dihydroxy_8_CarboxynaphthaleneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxy-8-carboxynaphthalene","+","O2","=","2-carboxy-2-hydroxy-8-carboxychromene","."),4352228). assertion_content_comment('oboGo_Number12_Dihydroxy_8_MethylnaphthaleneDioxygenaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxy-8-methylnaphthalene","+","O2","=","2-hydroxy-8-methylchromene-2-carboxylate","+","H","+"),4352192). assertion_content_comment('oboGo_Number12Dihydroxyfluorene11AlphaDioxygenaseactivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxyfluorene","+","O2","=","2-hydroxy-4-","(","2-oxo-1",",","3-dihydro-2H-inden-1-ylidene",")","but-2-enoic","acid","."),4278873). assertion_content_comment('oboGo_Number12_Dihydroxynaphthalene_6_Sulfonate18a_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxynaphthalene-6-sulfonate","+","O2","=","H","+","+","(","Z",")","-4-","(","2-hydroxy-5-sulfonatophenyl",")","-2-oxo-3-butenoate","."),4278836). assertion_content_comment('oboGo_Number12Dihydroxynaphthalenedioxygenaseactivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxynaphthalene","+","O2","=","2-hydroxychromene-2-carboxylate",".","C6","of","the","substrate","molecular","may","have","an","NH2","group","attached","."),4278912). assertion_content_comment('oboGo_Number12DihydroxyPhenanthreneglycosyltransferaseactivity',s("Catalysis","of","the","reaction",":","1",",","2-dihydroxyphenanthrene","+","UDP-glucose","=","2-hydroxy-1-phenanthryl-beta-D-glucopyranoside","+","UDP","."),4275117). assertion_content_comment('oboGo_Number12Hydroxydihydrochelirubine12OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","12-hydroxydihydrochelirubine","+","S-adenosyl-L-methionine","(","1","+",")","=","S-adenosyl-L-homocysteine","+","dihydromacarpine","+","H","(","+",")"),4309242). assertion_content_comment('oboGo_Number12Oxophytodienoatereductaseactivity',s("Catalysis","of","the","reaction",":","8-","[","(","1R",",","2R",")","-3-oxo-2-","{","(","Z",")","-pent-2-en-1-yl","}","cyclopentyl","]","octanoate","+","NADP","(","+",")","=","(","15Z",")","-12-oxophyto-10",",","15-dienoate","+","H","(","+",")","+","NADPH","."),4305821). assertion_content_comment('oboGo_Number1346_Tetrachloro_14_CyclohexadieneHalidohydrolaseActivity',s("Catalysis","of","the","reaction",":","alkyl","halide","+","H2O","=","alcohol","+","HCl",".","Substrates","are","1",",","3","(","R",")",",","4",",","6","(","R",")","-tetrachloro-1",",","4-cyclohexadiene","(","forms","2",",","4",",","5-trichloro-2",",","5-cyclohexadiene-1-ol",")","and","2",",","4",",","5-trichloro-2",",","5-cyclohexadiene-1-ol","(","forms","2",",","5-dichloro-2",",","5-cyclohexadiene-1",",","4-diol",")"),4274406). assertion_content_comment('oboGo_Number1_35_Dichloro_26_Dihydroxy_4_MethoxyphenylHexan_1_OneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","1-","(","3",",","5-dichloro-2",",","6-dihydroxy-4-methoxyphenyl",")","hexan-1-one",",","also","known","as","DIF-1",",","differentiation-inducing","factor-1",".","DIF-1","is","a","secreted","chlorinated","molecule","that","controls","cell","fate","during","development","of","Dictyostelium","cells","."),4318814). assertion_content_comment('oboGo_Number13AlphaGlucanbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","alpha-1",",","3","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-alpha-D-glucosidic","bonds","."),4130593). assertion_content_comment('oboGo_Number13AlphaGlucanmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","alpha-1",",","3","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-alpha-D-glucosidic","bonds","."),4130588). assertion_content_comment('oboGo_Number13AlphaLFucosidaseactivity',s("Catalysis","of","the","hydrolysis","of","1",",","3-linkages","between","alpha-L-fucose","and","N-acetylglucosamine","residues","in","glycoproteins","."),4344788). assertion_content_comment('oboGo_Number13BetaDGlucanbinding',s("Interacting","selectively","and","non-covalently","with","1",",","3-beta-D-glucans","."),4384366). assertion_content_comment('oboGo_Number13BetaDGlucanbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta-1",",","3","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-beta-D-glucosidic","bonds","."),4063972). assertion_content_comment('oboGo_Number13BetaDGlucancatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","beta-1",",","3","glucans","."),4225063). assertion_content_comment('oboGo_Number13BetaDGlucanmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","beta-1",",","3","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-beta-D-glucosidic","bonds","."),4063945). assertion_content_comment('oboGo_Number13BetaDGlucanphosphorylaseactivity',s("Catalysis","of","the","reaction",":","1",",","3-beta-D-glucosyl","(","n",")","+","phosphate","=","1",",","3-beta-D-glucosyl","(","n-1",")","+","alpha-D-glucose","1-phosphate",";","substrates","include","laminarin","."),4371682). assertion_content_comment('oboGo_Number13BetaDGlucanreceptoractivity',s("Combining","with","1",",","3-beta-D","glucans","to","initiate","a","change","in","cell","activity","."),4384380). assertion_content_comment('oboGo_Number13BetaDGlucansynthaseactivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","1",",","3-beta-D-glucosyl","(","n",")","=","UDP","+","1",",","3-beta-D-glucosyl","(","n","+","1",")"),4188593). assertion_content_comment('oboGo_Number13BetaDGlucansynthasecomplex',s("A","protein","complex","that","catalyzes","the","transfer","of","a","glucose","group","from","UDP-glucose","to","a","1",",","3-beta-D-glucan","chain","."),4346105). assertion_content_comment('oboGo_Number13BetaGalactosylNAcetylhexosaminephosphorylaseactivity',s("Catalysis","of","the","reaction",":","phosphate","+","beta-D-galactopyranosyl-","(","1",",","3",")","-N-acetyl-D-glucosamine","=","N-acetyl-D-glucosamine","+","alpha-D-galactopyranose","1-phosphate","."),4269723). assertion_content_comment('oboGo_Number13BetaGlucanosyltransferaseactivity',s("Catalysis","of","the","splitting","and","linkage","of","1",",","3-beta-glucan","molecules",",","resulting","in","1",",","3-beta-glucan","chain","elongation","."),4313865). assertion_content_comment('oboGo_Number13BetaOligoglucanphosphorylaseactivity',s("Catalysis","of","the","reaction",":","oligomeric","1",",","3-beta-D-glucosyl","(","n",")","+","phosphate","=","1",",","3-beta-D-glucosyl","(","n-1",")","+","alpha-D-glucose","1-phosphate","."),4371696). assertion_content_comment('oboGo_Number13_Dichloro_2_PropanolBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","1",",","3-dichloro-2-propanol","(","DCP",")",",","a","halohydrin","suspected","of","being","carcinogenic",",","mutagenic","and","genotoxic","."),4349718). assertion_content_comment('oboGo_Number13_Dichloro_2_PropanolCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","1",",","3-dichloro-2-propanol","(","DCP",")",",","a","halohydrin","suspected","of","being","carcinogenic",",","mutagenic","and","genotoxic","."),4349610). assertion_content_comment('oboGo_Number13_Dichloro_2_PropanolMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","1",",","3-dichloro-2-propanol","(","DCP",")",",","a","halohydrin","suspected","of","being","carcinogenic",",","mutagenic","and","genotoxic",".","DCP","is","used","as","a","general","solvent",",","as","an","intermediate","in","organic","synthesis","and","in","paints",",","varnishes",",","lacquers",",","water","colors",",","binders","and","photographic","lacquers","."),4272294). assertion_content_comment('oboGo_Number13Dichloropropenemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","members","of","the","1",",","3-dichloropropene","family",",","which","includes","cis-","and","trans-1",",","3-dichloropropene",".","The","1",",","3-dichloropropenes","are","chlorinated","hydrocarbons","and","the","major","active","ingredients","of","commercial","products","for","control","of","plant-parasitic","nematodes","."),4272307). assertion_content_comment('oboGo_Number13Hydroxydocosanoate13BetaGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","13-hydroxydocosanoate","+","UDP-D-glucose","=","13-beta-D-glucosyloxydocosanoate","+","UDP","."),4366542). assertion_content_comment('oboGo_Number13HydroxylupinineoTigloyltransferaseactivity',s("Catalysis","of","the","reaction",":","13-hydroxylupanine","+","2-methylcrotonoyl-CoA","=","13-","(","2-methylcrotonoyloxy",")","lupanine","+","CoA","."),4367739). assertion_content_comment('oboGo_Number13Propanedioldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","propane-1",",","3-diol","+","NAD","+","=","3-hydroxypropanal","+","NADH","+","H","+"),4371472). assertion_content_comment('oboGo_Number14_3_3ProteinBinding',s("Interacting","selectively","and","non-covalently","with","a","14-3-3","protein",".","A","14-3-3","protein","is","any","of","a","large","family","of","approximately","30kDa","acidic","proteins","which","exist","primarily","as","homo-","and","heterodimers","within","all","eukaryotic","cells",",","and","have","been","implicated","in","the","modulation","of","distinct","biological","processes","by","binding","to","specific","phosphorylated","sites","on","diverse","target","proteins",",","thereby","forcing","conformational","changes","or","influencing","interactions","between","their","targets","and","other","molecules",".","Each","14-3-3","protein","sequence","can","be","roughly","divided","into","three","sections",":","a","divergent","amino","terminus",",","the","conserved","core","region","and","a","divergent","carboxyl","terminus",".","The","conserved","middle","core","region","of","the","14-3-3s","encodes","an","amphipathic","groove","that","forms","the","main","functional","domain",",","a","cradle","for","interacting","with","client","proteins","."),4170708). assertion_content_comment('oboGo_Number14AlphaDGlucan1AlphaDGlucosylmutaseactivity',s("Catalysis","of","the","reaction",":","4-","(","1",",","4-alpha-D-glucosyl",")","(","n-1",")","-D-glucose","=","1-alpha-D-","(","1",",","4-alpha-D-glucosyl",")","(","n-1",")","-alpha-D-glucopyranoside","."),4369714). assertion_content_comment('oboGo_Number14AlphaGlucan6AlphaGlucosyltransferaseactivity',s("Catalysis","of","the","transfer","an","alpha-D-glucosyl","residue","in","a","1",",","4-alpha-D-glucan","to","the","primary","hydroxy","group","of","glucose",",","free","or","combined","in","a","1",",","4-alpha-D-glucan","."),4330623). assertion_content_comment('oboGo_Number14AlphaGlucanbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","alpha-1",",","4","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","4-alpha-D-glucosidic","bonds","."),4176873). assertion_content_comment('oboGo_Number14AlphaGlucanbranchingenzymeactivity',s("Catalysis","of","the","transfer","of","a","segment","of","a","1",",","4-alpha-D-glucan","chain","to","a","primary","hydroxyl","group","in","a","similar","glucan","chain","."),4188567). assertion_content_comment('oboGo_Number14AlphaGlucanmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","alpha-1",",","4","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","4-alpha-D-glucosidic","bonds","."),4176868). assertion_content_comment('oboGo_Number14BetaDXylansynthaseactivity',s("Catalysis","of","the","reaction",":","UDP-D-xylose","+","1",",","4-beta-D-xylan","(","n",")","=","UDP","+","1",",","4-beta-D-xylan","(","n","+","1",")"),4371457). assertion_content_comment('oboGo_Number14Dichlorobenzenecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","1",",","4-dichlorobenzene","(","p-dichlorobenzene","or","paramoth",")",",","a","derivative","of","benzene","with","two","chlorine","atoms","attached","at","opposite","positions","on","the","ring","."),4238332). assertion_content_comment('oboGo_Number14Dichlorobenzenemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","1",",","4-dichlorobenzene","(","p-dichlorobenzene","or","paramoth",")",",","a","derivative","of","benzene","with","two","chlorine","atoms","attached","at","opposite","positions","on","the","ring",".","It","forms","white","crystals","at","room","temperature","and","is","used","as","an","insecticidal","fumigant",",","particularly","in","mothballs","."),4238328). assertion_content_comment('oboGo_Number14Dihydroisonicotinate23Dioxygenaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","1",",","4-dihydroisonicotinate","+","O2","=","gamma-N-formylaminovinylacetaldehyde","+","CO2","."),4351104). assertion_content_comment('oboGo_Number14_Dihydroxy_2_NaphthoateOctaprenyltransferaseActivity',s("Catalysis","of","the","reaction",":","1",",","4-dihydroxy-2-naphthoate","+","polyprenylpyrophosphate","=","dimethylmenaquinone","+","diphosphate","+","CO2","."),4351247). assertion_content_comment('oboGo_Number14_Dihydroxy_2_Naphthoyl_CoASynthaseActivity',s("Catalysis","of","the","reaction",":","O-succinylbenzoyl-CoA","=","1",",","4-dihydroxy-2-naphthoate","+","CoA","."),4248798). assertion_content_comment('oboGo_Number1_4_Iodo_25_DimethoxyphenylPropan_2_AmineBinding',s("Interacting","selectively","and","non-covalently","with","the","amine","1-","(","4-iodo-2",",","5-dimethoxyphenyl",")","propan-2-amine",",","a","serotonin","receptor","agonist","that","can","act","as","a","psychedelic","drug","."),4170737). assertion_content_comment('oboGo_Number14Lactonaseactivity',s("Catalysis","of","the","reaction",":","H2O","+","a","1",",","4-lactone","=","a","4-hydroxyacid","."),4266412). assertion_content_comment('oboGo_Number1516Dihydrobiliverdin_Ferredoxinoxidoreductaseactivity',s("Catalysis","of","the","reaction",":","15",",","16-dihydrobiliverdin","+","oxidized","ferredoxin","=","biliverdin","IXa","+","reduced","ferredoxin","."),4278013). assertion_content_comment('oboGo_Number15AnhydroDFructosedehydrataseactivity',s("Catalysis","of","the","reaction",":","1",",","5-anhydro-D-fructose","=","1",",","5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose","+","H2O","."),4345207). assertion_content_comment('oboGo_Number15AnhydroDFructosereductase15AnhydroDMannitolFormingactivity',s("Catalysis","of","the","reaction",":","1",",","5-anhydro-D-mannitol","+","NADP","(","+",")","=","1",",","5-anhydro-D-fructose","+","H","(","+",")","+","NADPH","."),4341988). assertion_content_comment('oboGo_Number15AnhydroDFructosereductaseactivity',s("Catalysis","of","the","reaction",":","1",",","5-anhydro-D-glucitol","+","NADP","(","+",")","=","1",",","5-anhydro-D-fructose","+","H","(","+",")","+","NADPH","."),4268531). assertion_content_comment('oboGo_Number15Hydroxyicosatetraenoatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","+","+","(","15S",")","-15-hydroxy-5",",","8",",","11-cis-13-trans-icosatetraenoate","=","NAD","(","P",")","H","+","H","+","+","15-oxo-5",",","8",",","11-cis-13-trans-icosatetraenoate","."),4364317). assertion_content_comment('oboGo_Number15HydroxyprostaglandinDdehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","(","5Z",",","13E",")","-","(","15S",")","-9-alpha",",","15-dihydroxy-11-oxoprosta-5",",","13-dienoate","=","NADPH","+","H","+","+","(","5Z",",","13E",")","-9-alpha-hydroxy-11",",","15-dioxoprosta-5",",","13-dienoate","."),4363880). assertion_content_comment('oboGo_Number15Hydroxyprostaglandindehydrogenasenadactivity',s("Catalysis","of","the","reaction",":","(","5Z",",","13E",")","-","(","15S",")","-11-alpha",",","15-dihydroxy-9-oxoprost-13-enoate","+","NAD","+","=","(","5Z",",","13E",")","-11-alpha-hydroxy-9",",","15-dioxoprost-13-enoate","+","NADH","+","H","+"),4304820). assertion_content_comment('oboGo_Number15Hydroxyprostaglandindehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","prostaglandin","E","(","1",")","=","15-dehydro-prostaglandin","E1","+","H","(","+",")","+","NADPH","."),4363903). assertion_content_comment('oboGo_Number15HydroxyprostaglandinIdehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","prostaglandin","I","(","2",")","=","15-dehydro-prostaglandin","I","(","2",")","+","H","(","+",")","+","NADPH","."),4364303). assertion_content_comment('oboGo_Number15Oxoprostaglandin13Oxidaseactivity',s("Catalysis","of","the","reaction",":","(","5Z",")","-","(","15S",")","-11-alpha-hydroxy-9",",","15-dioxoprostanoate","+","NAD","(","P",")","+","=","(","5Z",")","-","(","15S",")","-11-alpha-hydroxy-9",",","15-dioxoprosta-13-enoate","+","NAD","(","P",")","H","+","H","+"),4371499). assertion_content_comment('oboGo_Number1_5_Phosphoribosyl_5_5_PhosphoribosylaminoMethylideneaminoImidazole_4_CarboxamideIsomeraseActivity',s("Catalysis","of","the","reaction",":","1-","(","5-phosphoribosyl",")","-5-","[","(","5-phosphoribosylamino",")","methylideneamino","]","imidazole-4-carboxamide","=","5-","[","(","5-phospho-1-deoxy-D-ribulos-1-ylimino",")","methylamino","]","-1-","(","5-phospho-D-ribosyl",")","imidazole-4-carboxamide","."),4184810). assertion_content_comment('oboGo_Number16AlphaHydroxyprogesteronedehydrataseactivity',s("Catalysis","of","the","reaction",":","16-alpha-hydroxyprogesterone","=","H2O","+","16-dehydroprogesterone","."),4369321). assertion_content_comment('oboGo_Number16AlphaHydroxysteroiddehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","16-alpha-hydroxysteroid","=","NADPH","+","H","+","+","16-oxosteroid","."),4364494). assertion_content_comment('oboGo_Number16AlphaLFucosidaseactivity',s("Catalysis","of","the","hydrolysis","of","1",",","6-linkages","between","alpha-L-fucose","and","N-acetyl-D-glucosamine","in","glycopeptides","such","as","immunoglobulin","G","glycopeptide","and","fucosyl-asialo-agalacto-fetuin","."),4344809). assertion_content_comment('oboGo_Number16BetaGlucanbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta-1",",","6","glucans","."),4114291). assertion_content_comment('oboGo_Number16BetaGlucancatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","beta-1",",","6","glucans","."),4225045). assertion_content_comment('oboGo_Number16BetaGlucanmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","beta-1",",","6","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","6-beta-D-glucosidic","bonds","."),4114285). assertion_content_comment('oboGo_Number16_Dihydroxy_5_Methylcyclohexa_24_DienecarboxylateDehydrogenaseActivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","1",",","6-dihydroxy-5-methylcyclohexa-2",",","4-dienecarboxylate","+","NAD","+","=","3-methylcatechol","+","CO2","+","NADH","+","H","+"),4278532). assertion_content_comment('oboGo_Number16_Dihydroxycyclohexa_24_Diene_1_CarboxylateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","+","+","1",",","6-dihydroxycyclohexa-2",",","4-diene-1-carboxylate","=","NADH","+","CO2","+","catechol","."),4365885). assertion_content_comment('oboGo_Number16Hydroxysteroidepimeraseactivity',s("Catalysis","of","the","reaction",":","16-alpha-hydroxysteroid","=","16-beta-hydroxysteroid","."),4371555). assertion_content_comment('oboGo_Number16_Methoxy_23_Dihydro_3_HydroxytabersonineN_MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-hydroxy-16-methoxy-2",",","3-dihydrotabersonine","+","S-adenosyl-L-methionine","=","S-adenosyl-L-homocysteine","+","deacetoxyvindoline","+","H","(","+",")"),4308470). assertion_content_comment('oboGo_Number17_Alpha20_Alpha_Dihydroxypregn_4_En_3_OneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","+","+","17-alpha",",","20-alpha-dihydroxypregn-4-en-3-one","=","NAD","(","P",")","H","+","H","+","+","17-alpha-hydroxyprogesterone","."),4364428). assertion_content_comment('oboGo_Number17AlphaHydroxyprogesteronealdolaseactivity',s("Catalysis","of","the","reaction",":","17-alpha-hydroxyprogesterone","=","acetaldehyde","+","4-androstene-3",",","17-dione","."),4370187). assertion_content_comment('oboGo_Number17BetaHydroxysteroiddehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","a","17-beta-hydroxysteroid","+","NADP","+","=","a","17-oxosteroid","+","NADPH","+","H","+"),4157662). assertion_content_comment('oboGo_Number17BetaKetosteroidreductaseactivity',s("Catalysis","of","the","reaction",":","a","17-beta-ketosteroid","+","NADPH","+","H","+","=","a","17-beta-hydroxysteroid","+","NADP","+"),4157888). assertion_content_comment('oboGo_Number17ODeacetylvindolineoAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","1R",",","9R",",","10S",",","11R",",","12R",",","19R",")","-12-ethyl-10",",","11-dihydroxy-5-methoxy-10-","(","methoxycarbonyl",")","-8-methyl-8",",","16-diazapentacyclo","[","10.6.1.0","^","{","1",",","9","}",".0","^","{","2",",","7","}",".0","^","{","16",",","19","}","]","nonadeca-2","(","7",")",",","3",",","5",",","13-tetraen-16-ium","+","acetyl-CoA","=","(","1R",",","9R",",","10S",",","11R",",","12R",",","19R",")","-11-","(","acetyloxy",")","-12-ethyl-10-hydroxy-5-methoxy-10-","(","methoxycarbonyl",")","-8-methyl-8",",","16-diazapentacyclo","[","10.6.1.0","^","{","1",",","9","}",".0","^","{","2",",","7","}",".0","^","{","16",",","19","}","]","nonadeca-2","(","7",")",",","3",",","5",",","13-tetraen-16-ium","+","CoA","."),4365275). assertion_content_comment('oboGo_Number1_Acylglycerol_3_PhosphateO_AcyltransferaseActivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","1-acyl-sn-glycerol-3-phosphate","=","CoA","+","1",",","2-diacyl-sn-glycerol-3-phosphate","."),4188511). assertion_content_comment('oboGo_Number1AcylglycerophosphocholineoAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-acyl-sn-glycero-3-phosphocholine","+","acyl-CoA","=","phosphatidylcholine","+","CoA","."),4366224). assertion_content_comment('oboGo_Number1_Alkenyl_2_AcylglycerolCholinePhosphotransferaseActivity',s("Catalysis","of","the","reaction",":","1-alkenyl-2-acylglycerol","+","CDP-choline","=","plasmenylcholine","+","CMP","."),4368000). assertion_content_comment('oboGo_Number1AlkenylglycerophosphocholineoAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-alkenylglycerophosphocholine","+","acyl-CoA","=","1-alkenyl-2-acylglycerophosphocholine","+","CoA","."),4365306). assertion_content_comment('oboGo_Number1AlkenylglycerophosphoethanolamineoAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-alkenylglycerophosphoethanolamine","+","acyl-CoA","=","1-alkenyl-2-acyl-glycerophosphoethanolamine","+","CoA","."),4365242). assertion_content_comment('oboGo_Number1_Alkyl_2_AcetylglycerolO_AcyltransferaseActivity',s("Catalysis","of","the","reaction",":","1-O-alkyl-2-acetyl-sn-glycerol","+","acyl-CoA","=","1-O-alkyl-2-acetyl-3-acyl-sn-glycerol","+","CoA","."),4365171). assertion_content_comment('oboGo_Number1_Alkyl_2_AcetylglycerophosphocholineEsteraseActivity',s("Catalysis","of","the","reaction",":","2-acetyl-1-alkyl-sn-glycero-3-phosphocholine","+","H2O","=","1-alkyl-sn-glycero-3-phosphocholine","+","acetate","."),4188972). assertion_content_comment('oboGo_Number1_Alkyl_2_AcetylglycerophosphocholineEsteraseComplex',s("An","enzyme","complex","composed","of","two","catalytic","alpha","subunits",",","which","form","a","catalytic","dimer",",","and","a","non-catalytic",",","regulatory","beta","subunit",";","the","catalytic","dimer","may","be","an","alpha1/alpha1","or","alpha2/alpha2","homodimer",",","or","an","alpha1/alpha2","heterodimer",".","Modulates","the","action","of","platelet-activating","factor","(","PAF",")"),4255951). assertion_content_comment('oboGo_Number1AlkylglycerophosphocholineoAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-alkyl-sn-glycero-3-phosphocholine","+","acetyl-CoA","=","1-alkyl-2-acetyl-sn-glycero-3-phosphocholine","+","CoA","."),4366167). assertion_content_comment('oboGo_Number1AlkylglycerophosphocholineoAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-alkyl-sn-glycero-3-phosphocholine","+","acyl-CoA","=","1-alkyl-2-acyl-sn-glycero-3-phosphocholine","+","CoA","."),4366099). assertion_content_comment('oboGo_Number1Alpha25Dihydroxyvitamind324Hydroxylaseactivity',s("Catalysis","of","the","hydroxylation","of","C-24","of","1-alpha",",","25-hydroxycholecalciferol","(","25-hydroxyvitamin","D3",";","calcitriol",")"),4309652). assertion_content_comment('oboGo_Number1_Aminocyclopropane_1_CarboxylateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","1-aminocyclopropane-1-carboxylate",",","a","natural","product","found","in","plant","tissues",".","It","is","a","key","intermediate","in","the","biosynthesis","of","ethylene","(","ethene",")",",","a","fruit-ripening","hormone","in","plants","."),4314243). assertion_content_comment('oboGo_Number1_Aminocyclopropane_1_CarboxylateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","1-aminocyclopropane-1-carboxylate",",","a","natural","product","found","in","plant","tissues",".","It","is","a","key","intermediate","in","the","biosynthesis","of","ethylene","(","ethene",")",",","a","fruit-ripening","hormone","in","plants","."),4314270). assertion_content_comment('oboGo_Number1_Aminocyclopropane_1_CarboxylateDeaminaseActivity',s("Catalysis","of","the","reaction",":","1-aminocyclopropane-1-carboxylate","+","H","(","2",")","O","=","2-oxobutanate","+","NH","(","4",")","(","+",")"),4250987). assertion_content_comment('oboGo_Number1_Aminocyclopropane_1_CarboxylateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","1-aminocyclopropane-1-carboxylate",",","the","anion","of","1-aminocyclopropane-1-carboxylic","acid",",","a","natural","product","found","in","plant","tissues",".","It","is","a","key","intermediate","in","the","biosynthesis","of","ethylene","(","ethene",")",",","a","fruit-ripening","hormone","in","plants","."),4273169). assertion_content_comment('oboGo_Number1_Aminocyclopropane_1_CarboxylateOxidaseActivity',s("Catalysis","of","the","reaction",":","1-aminocyclopropane-1-carboxylate","+","L-ascorbate","+","O","(","2",")","=","CO","(","2",")","+","dehydroascorbate","+","ethylene","+","2","H","(","2",")","O","+","hydrogen","cyanide",".","Ethene","is","also","known","as","ethylene","."),4262479). assertion_content_comment('oboGo_Number1_Aminocyclopropane_1_CarboxylateSynthaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","=","1-aminocyclopropane-1-carboxylate","+","S-methyl-5","'","-thioadenosine","+","H","(","+",")"),4301725). assertion_content_comment('oboGo_Number1Butanolbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","1-butanol",",","an","alkyl","primary","alcohol","with","the","formula","C4H10O","."),4166725). assertion_content_comment('oboGo_Number1Butanolmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","1-butanol",",","an","alkyl","primary","alcohol","with","the","formula","C4H10O","."),4166720). assertion_content_comment('oboGo_Number1_Chloro_22_Bis4_ChlorophenylEthaneDehydrochlorinaseActivity',s("Catalysis","of","the","reaction",":","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethane","=","HCl","+","unsym-bis","(","4-chlorophenyl",")","ethene",".","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethane","is","also","known","as","DDMS",";","unsym-bis","(","4-chlorophenyl",")","ethene","is","also","known","as","DDNU","."),4273660). assertion_content_comment('oboGo_Number1_Chloro_22_Bis4_ChlorophenylEthaneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethene","+","2","H","+","+","2","e-","=","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethane",".","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethene","is","also","known","as","DDMU",";","1-chloro-2",",","2-bis","(","4-chlorophenyl",")","ethane","is","also","known","as","DDMS","."),4277249). assertion_content_comment('oboGo_Number1_Chloro_4_NitrosobenzeneNitroreductaseActivity',s("Catalysis","of","the","reaction",":","1-chloro-4-nitrosobenzene","+","NADPH","+","H","+","=","1-chloro-4-hydroxylaminobenzene","+","NADP","+","+","H2O","."),4190998). assertion_content_comment('oboGo_Number1D_1_Guanidino_3_Amino_13_Dideoxy_Scyllo_InositolTransaminaseActivity',s("Catalysis","of","the","reaction",":","1D-1-guanidino-3-amino-1",",","3-dideoxy-scyllo-inositol","+","pyruvate","=","1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol","+","L-alanine","."),4368838). assertion_content_comment('oboGo_Number1_Deoxy_D_Xylulose_5_PhosphateReductoisomeraseActivity',s("Catalysis","of","the","reaction",":","2-C-methyl-D-erythritol","4-phosphate","+","NADP","(","+",")","=","1-deoxy-D-xylulose","5-phosphate","+","H","(","+",")","+","NADPH","."),4308382). assertion_content_comment('oboGo_Number1_Deoxy_D_Xylulose_5_PhosphateSynthaseActivity',s("Catalysis","of","the","reaction",":","D-glyceraldehyde","3-phosphate","+","H","(","+",")","+","pyruvate","=","1-deoxy-D-xylulose","5-phosphate","+","CO","(","2",")"),4251017). assertion_content_comment('oboGo_Number1_Hydro_11a_Dihydroxy_9_FluorenoneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","1-hydro-1",",","1a-dihydroxy-9-fluorenone","+","H2O","=","2",",","3-dihydroxy-2","'","-carboxybiphenyl","+","3","H","+","+","2","e-","."),4349598). assertion_content_comment('oboGo_Number1_Hydroxy_2_NaphthaldehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","1-hydroxy-2-naphthaldehyde","+","NAD","+","+","H2O","=","NADH","+","H","+","+","1-hydroxy-2-naphthoate","."),4277520). assertion_content_comment('oboGo_Number1_Hydroxy_2_Naphthoate12_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","1-hydroxy-2-naphthoate","+","O2","=","(","3E",")","-4-","(","2-carboxyphenyl",")","-2-oxobut-3-enoate","."),4275377). assertion_content_comment('oboGo_Number1_Hydroxy_2_NaphthoateHydroxylaseActivity',s("Catalysis","of","the","reaction",":","1-hydroxy-2-naphthoate","+","O2","+","NADPH","+","2","H","+","=","NADP","+","+","H2O","+","CO2","+","1",",","2-dihydroxynaphthalene","."),4275904). assertion_content_comment('oboGo_Number1_Hydroxy_2_Oxolimonene12_MonooxygenaseActivity',s("Catalysis","of","the","reaction",":","(","1S",",","4R",")","-1-hydroxy-2-oxolimonene","+","NADPH","+","O2","=","NADP","+","+","OH-","+","(","3R",")","-3-isopropenyl-6-oxoheptanoate","."),4276258). assertion_content_comment('oboGo_Number1_Hydroxy_44_Dimethylpentan_3_OneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","1-hydroxy-4",",","4-dimethylpentan-3-one","=","4",",","4-dimethyl-3-oxopentanal","+","2","H","+","+","2","e-","."),4351010). assertion_content_comment('oboGo_Number1_Hydroxy_6_MethoxypyreneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","1-hydroxy-6-methoxypyrene","+","XCH3","=","1",",","6-dimethoxypyrene","+","HX","."),4348896). assertion_content_comment('oboGo_Number1_Hydroxycyclohexan_1_YlAcetyl_CoALyaseActivity',s("Catalysis","of","the","reaction",":","(","1-hydroxycyclohexan-1-yl",")","acetyl-CoA","=","acetyl-CoA","+","cyclohexanone","."),4370244). assertion_content_comment('oboGo_Number1Hydroxypyrene67Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","1-hydroxypyrene","+","O2","+","2","H","+","+","2","e-","=","1-hydroxypyrene-6",",","7-oxide","+","H2O","."),4350259). assertion_content_comment('oboGo_Number1Hydroxypyrene78Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","1-hydroxypyrene","+","O2","+","2","H","+","+","2","e-","=","1-hydroxypyrene-7",",","8-oxide","+","H2O","."),4350331). assertion_content_comment('oboGo_Number1Hydroxypyrenemethyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-hydroxypyrene","+","XCH3","=","1-methoxypyrene","+","HX","."),4350250). assertion_content_comment('oboGo_Number1Hydroxypyrenesulfotransferaseactivity',s("Catalysis","of","the","reaction",":","1-hydroxypyrene","+","XSO3-","=","1-pyrenylsulfate","+","HX","."),4350241). assertion_content_comment('oboGo_Number1Indanonedioxygenaseactivity',s("Catalysis","of","the","reaction",":","1-indanone","+","NADPH","+","1/2","O2","=","NADP","+","+","3-hydroxy-1-indanone","."),4276934). assertion_content_comment('oboGo_Number1Indanonemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","1-indanone","+","NADPH","+","1/2","O2","=","NADP","+","+","3",",","4-dihydrocoumarin","."),4277001). assertion_content_comment('oboGo_Number1Methoxypyrene67Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","1-methoxypyrene","+","O2","+","2","H","+","+","2","e-","=","1-methoxypyrene-6",",","7-oxide","+","H2O","."),4348905). assertion_content_comment('oboGo_Number1Methyladenosinenucleosidaseactivity',s("Catalysis","of","the","reaction",":","1-methyladenosine","+","H","(","2",")","O","=","1-methyladenine","+","ribofuranose","."),4371445). assertion_content_comment('oboGo_Number1Methylguanosinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","1-methylguanosine","."),4181414). assertion_content_comment('oboGo_Number1Methylnaphthalenehydroxylaseactivity',s("Catalysis","of","the","reaction",":","1-methylnaphthalene","+","NADH","+","H","+","+","O2","=","1-hydroxymethylnaphthalene","+","NAD","+","+","H2O","."),4352183). assertion_content_comment('oboGo_Number1Methylpentylsuccinatesynthaseactivity',s("Catalysis","of","the","reaction",":","fumarate","+","n-hexane","=","(","1-methylpentyl",")","succinate","."),4352669). assertion_content_comment('oboGo_Number1Naphthaldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","1-naphthaldehyde","+","NAD","+","+","H2O","=","1-naphthoic","acid","+","NADH","+","H","+"),4352210). assertion_content_comment('oboGo_Number1Naphthoicaciddioxygenaseactivity',s("Catalysis","of","the","reaction",":","1-naphthoic","acid","+","NADH","+","O2","+","H","+","=","cis-1",",","2-dihydroxy-1",",","2-dihydro-8-carboxynaphthalene","+","NAD","+"),4352091). assertion_content_comment('oboGo_Number1_Nitro_12_Dihydro_135_TriazineHydrolaseActivity',s("Catalysis","of","the","reaction",":","1-nitro-1",",","2-dihydro-1",",","3",",","5-triazine","+","2","H2O","=","1-nitro-1",",","3",",","5-triazinane-2",",","4-diol","."),4352579). assertion_content_comment('oboGo_Number1_Oxa_2_OxocycloheptaneLactonaseActivity',s("Catalysis","of","the","reaction",":","1-oxa-2-oxocycloheptane","+","H2O","=","6-hydroxyhexanoate","."),4275099). assertion_content_comment('oboGo_Number1Phenanthrolglycosyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-phenanthrol","+","glucose","=","1-phenanthryl-beta-D-glucopyranoside","+","H2O","."),4275228). assertion_content_comment('oboGo_Number1Phenanthrolmethyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-phenanthrol","+","X-CH3","=","X","+","1-methoxyphenanthrene","."),4275219). assertion_content_comment('oboGo_Number1Phenanthrolsulfotransferaseactivity',s("Catalysis","of","the","reaction",":","1-phenanthrol","+","X-SO3","(","-",")","=","HX","+","1-phenanthrylsulfate","."),4275136). assertion_content_comment('oboGo_Number1Phenylethanoldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-1-phenylethanol","=","acetophenone","+","H2","."),4281667). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_3_KinaseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","+","ATP","=","a","1-phosphatidyl-1D-myo-inositol","3-phosphate","+","ADP","+","2","H","(","+",")"),4297617). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_3_KinaseRegulatorActivity',s("Modulates","the","activity","of","the","enzyme","1-phosphatidylinositol-3-kinase","activity","."),4297582). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_3_Phosphate5_KinaseActivity',s("Catalysis","of","the","reaction",":","a","1-phosphatidyl-1D-myo-inositol","3-phosphate","+","ATP","=","a","1-phosphatidyl-1D-myo-inositol","3",",","5-bisphosphate","+","ADP","+","2","H","(","+",")"),4346678). assertion_content_comment('oboGo_Number1Phosphatidylinositol4Kinaseactivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","+","ATP","=","1-phosphatidyl-1D-myo-inositol","4-phosphate","+","ADP","+","2","H","(","+",")"),4206460). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_4_Phosphate3_KinaseClassIAComplex',s("A","heterodimeric","protein","complex","that","possesses","1-phosphatidylinositol-4-phosphate","3-kinase","activity",";","comprises","a","catalytic","Class","IA","phosphoinositide","3-kinase","(","PI3K",")","subunit","of","110-120","kDa","and","an","associated","SH2","domain-containing","regulatory","subunit","that","is","a","member","of","a","family","of","related","proteins","often","called","p85","proteins",".","Class","I","PI3Ks","phosphorylate","phosphatidylinositol","[","PI","]",",","phosphatidylinositol-4-phosphate","[","PI","(","4",")","P","]","and","phosphatidylinositol-4",",","5-bisphosphate","[","PI","(","4",",","5",")","P2","]",",","and","are","divided","into","subclasses","A","and","B","according","to","the","type","of","adaptor","subunit","with","which","they","associate",".","Through","the","interaction","with","the","SH2-containing","adaptor","subunits",",","Class","IA","PI3K","catalytic","subunits","are","linked","to","tyrosine","kinase","signaling","pathways","."),4220746). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_4_Phosphate3_KinaseClassIBComplex',s("A","heterodimeric","protein","complex","that","possesses","1-phosphatidylinositol-4-phosphate","3-kinase","activity",";","comprises","a","catalytic","Class","IB","phosphoinositide","3-kinase","(","PI3K",")","subunit","of","110-120","kDa","and","an","associated","regulatory","subunit","that","is","larger","than",",","and","unrelated","to",",","the","p85","proteins","present","in","class","IA","complexes",".","Class","I","PI3Ks","phosphorylate","phosphatidylinositol","[","PI","]",",","phosphatidylinositol-4-phosphate","[","PI","(","4",")","P","]","and","phosphatidylinositol-4",",","5-bisphosphate","[","PI","(","4",",","5",")","P2","]","and","are","divided","into","subclasses","A","and","B","according","to","the","type","of","adaptor","subunit","with","which","they","associate",".","Class","IB","PI3Ks","are","stimulated","by","G-proteins","and","do","not","interact","with","the","SH2-domain","containing","adaptors","that","bind","to","Class","IA","PI3Ks","."),4220733). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_4_Phosphate5_KinaseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","4-phosphate","+","ATP","=","1-phosphatidyl-1D-myo-inositol","4",",","5-bisphosphate","+","ADP","+","2","H","(","+",")"),4206522). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_4_PhosphateKinaseClassIA',s("OBSOLETE",".","A","class","I","PI3K","activated","by","tyrosine","phosphorylation","events","."),4206536). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_4_PhosphateKinaseClassIB',s("OBSOLETE",".","A","class","I","PI3K","activated","via","heterotrimeric","G-proteins","."),4206547). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_5_Phosphate4_KinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","1-phosphatidyl-1D-myo-inositol","5-phosphate","=","ADP","+","1-phosphatidyl-1D-myo-inositol","4",",","5-bisphosphate","."),4253640). assertion_content_comment('oboGo_Number1_Phosphatidylinositol_5_PhosphateKinase',s("OBSOLETE",".","Catalysis","of","the","reaction",":","diphosphate","+","a","purine","nucleoside","=","phosphate","+","a","purine","mononucleotide","."),4253647). assertion_content_comment('oboGo_Number1Phosphatidylinositolbinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylinositol",",","any","glycophospholipid","with","its","sn-glycerol","3-phosphate","residue","is","esterified","to","the","1-hydroxyl","group","of","1D-myo-inositol","."),4218908). assertion_content_comment('oboGo_Number1Phosphofructokinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","D-fructose","1-phosphate","=","ADP","+","D-fructose","1",",","6-bisphosphate","."),4251001). assertion_content_comment('oboGo_Number1_Pyrroline_4_Hydroxy_2_CarboxylateDeaminaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxy-1-pyrroline-2-carboxylate","+","H","(","2",")","O","+","H","(","+",")","=","2",",","5-dioxopentanoate","+","NH","(","4",")","(","+",")"),4369893). assertion_content_comment('oboGo_Number1_Pyrroline_5_CarboxylateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","1-pyrroline-5-carboxylate","+","NAD","+","+","H2O","=","L-glutamate","+","NADH","+","H","+"),4188622). assertion_content_comment('oboGo_Number1Pyrrolinedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","1-pyrroline","+","NAD","+","+","2","H2O","=","4-aminobutanoate","+","NADH","+","2","H","+"),4342405). assertion_content_comment('oboGo_Number21URnabinding',s("Interacting","selectively","and","non-covalently","with","a","21U-RNA",",","a","21-nucleotide","RNA","characterized","by","a","uridine","5","'","-monophosphate","and","a","modified","3","'","end","resistant","to","periodate","degradation",".","21U-RNAs","are","derived","from","distinct",",","autonomously","expressed","loci","within","the","genome","."),4352351). assertion_content_comment('oboGo_Number21URnacatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","21U-RNAs",",","a","class","of","single-stranded","RNA","molecules","of","about","21","nucleotides","in","length","characterized","by","a","uridine","5","'","-monophosphate","and","a","modified","3","'","end","resistant","to","periodate","degradation",".","21U-RNAs","are","derived","from","distinct",",","autonomously","expressed","loci","within","the","genome","."),4352395). assertion_content_comment('oboGo_Number21URnametabolicprocess',s("The","chemical","reactions","and","pathways","involving","21U-RNAs",",","a","class","of","single-stranded","RNA","molecules","of","about","21","nucleotides","in","length","characterized","by","a","uridine","5","'","-monophosphate","and","a","modified","3","'","end","resistant","to","periodate","degradation",".","21U-RNAs","are","derived","from","distinct",",","autonomously","expressed","loci","within","the","genome","."),4352384). assertion_content_comment('oboGo_Number223Trihydroxybiphenyldioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxybenzenoid","+","O2","=","H","+","+","distal","extradiol","ring","cleavage",".","Substrates","are","2",",","2","'",",","3-trihydroxybiphenyl","(","forms","2-hydroxy-6-oxo-6-","(","2-hydroxyphenyl",")","-hexa-2",",","4-dienoate",")","and","2",",","2","'",",","3-trihydroxydiphenylether","(","forms","2",",","3-hydroxy-6-oxo-6-","(","2-hydroxyphenyl",")","-hexa-2",",","4-dienoate",")"),4278864). assertion_content_comment('oboGo_Number22_Bis4_Hydroxyphenyl_1_PropanolHydroxylaseActivity',s("Catalysis","of","the","reaction",":","2",",","2-bis","(","4-hydroxyphenyl",")","-1-propanol","+","NADH","+","H","+","+","O2","=","2",",","3-bis","(","4-hydroxyphenyl",")","-1",",","2-propanediol","+","NAD","+","+","H2O","."),4352543). assertion_content_comment('oboGo_Number22Dialkylglycinedecarboxylasepyruvateactivity',s("Catalysis","of","the","reaction",":","2",",","2-dialkylglycine","+","H","(","+",")","+","pyruvate","=","L-alanine","+","CO","(","2",")","+","dialkyl","ketone","."),4370277). assertion_content_comment('oboGo_Number2_2_MethylthioEthylmalateSynthaseActivity',s("Catalysis","of","the","reaction",":","2-oxo-4-methylthiobutanoate","+","acetyl-CoA","+","H2O","=","2-","(","2","'","-methylthio",")","ethylmalic-acid","+","coenzyme","A","+","H","+"),4334209). assertion_content_comment('oboGo_Number2345_Tetrahydropyridine_26_DicarboxylateN_SuccinyltransferaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2",",","3",",","4",",","5-tetrahydrodipicolinate","+","H","(","2",")","O","+","succinyl-CoA","=","L-2-succinylamino-6-oxopimelate","+","CoA","."),4251065). assertion_content_comment('oboGo_Number236Trihydroxyisonicotinatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","2",",","3",",","6-trihydroxyisonicotinate","=","2",",","3",",","6-trihydroxypyridine","+","CO2","."),4351028). assertion_content_comment('oboGo_Number23_Bis4_Hydroxyphenyl_12_PropanediolDioxygenaseActivity',s("Catalysis","of","the","reaction",":","2",",","3-bis","(","4-hydroxyphenyl",")","-1",",","2-propanediol","+","O2","=","4-hydroxyphenacyl","alcohol","+","4-hydroxybenzoate","+","2","H","+","+","2","e-","."),4352570). assertion_content_comment('oboGo_Number23BisphosphoDGlycerate2Phosphohydrolaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-bisphospho-D-glycerate","+","H","(","2",")","O","=","3-phospho-D-glycerate","+","phosphate","."),4212339). assertion_content_comment('oboGo_Number23BisphosphoglycerateDependentphosphoglyceratemutaseactivity',s("Catalysis","of","the","reaction",":","2-phospho-D-glycerate","=","3-phospho-D-glycerate",";","this","reaction","requires","the","cofactor","2",",","3-bisphosphoglycerate","."),4358982). assertion_content_comment('oboGo_Number23BisphosphoglycerateIndependentphosphoglyceratemutaseactivity',s("Catalysis","of","the","reaction",":","2-phospho-D-glycerate","=","3-phospho-D","glycerate",";","this","reaction","does","not","require","the","cofactor","2",",","3-bisphosphoglycerate","."),4358971). assertion_content_comment('oboGo_Number23CyclicNucleotide2Phosphodiesteraseactivity',s("Catalysis","of","the","reaction",":","nucleoside","2","'",",","3","'","-cyclic","phosphate","+","H2O","=","nucleoside","3","'","-phosphate","."),4251043). assertion_content_comment('oboGo_Number23CyclicNucleotide3Phosphodiesteraseactivity',s("Catalysis","of","the","reaction",":","nucleoside","2","'",",","3","'","-cyclic","phosphate","+","H2O","=","nucleoside","2","'","-phosphate","."),4212050). assertion_content_comment('oboGo_Number23DiaminopropionatenOxalyltransferaseactivity',s("Catalysis","of","the","reaction",":","3-amino-L-alanine","+","oxalyl-CoA","=","N","(","3",")","-oxalyl-L-2",",","3-diaminopropanoate","+","CoA","."),4366329). assertion_content_comment('oboGo_Number23_Dihydro_23_DihydroxybenzoateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","2S",",","3S",")","-2",",","3-dihydroxy-2",",","3-dihydrobenzoate","+","NAD","(","+",")","=","2",",","3-dihydroxybenzoate","+","H","(","+",")","+","NADH","."),4251105). assertion_content_comment('oboGo_Number23_Dihydroxy_23_Dihydro_P_CumateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","cis-2",",","3-dihydroxy-2",",","3-dihydro-p-cumate","+","NAD","(","+",")","=","2",",","3-dihydroxy-p-cumate","+","H","(","+",")","+","NADH","."),4278457). assertion_content_comment('oboGo_Number23_Dihydroxy_23_Dihydro_PhenylpropionateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","cis-3-","(","3-carboxyethyl",")","-3",",","5-cyclohexadiene-1",",","2-diol","+","NAD","+","=","NADH","+","H","+","+","3-","(","2",",","3-dihydroxyphenyl",")","propionate","."),4277240). assertion_content_comment('oboGo_Number23_Dihydroxy_2_Carboxybiphenyl12_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxy-2","'","-carboxybiphenyl","+","O2","=","2-hydroxy-6-oxo-6-","(","2-carboxyphenyl",")","-hexa-2",",","4-dienoate","+","H","+"),4349589). assertion_content_comment('oboGo_Number23Dihydroxybenzoate23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxybenzoate","+","O","(","2",")","=","2-carboxy-cis",",","cis-muconate","+","2","H","(","+",")"),4365127). assertion_content_comment('oboGo_Number23Dihydroxybenzoate34Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxybenzoate","+","O","(","2",")","=","2-hydroxy-3-","(","3-oxoprop-1-enyl",")","but-2-enedioate","+","H","(","+",")"),4299967). assertion_content_comment('oboGo_Number23DihydroxybenzoateSerineligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","2",",","3-dihydroxybenzoate","+","L-serine","=","products","of","ATP","breakdown","+","N-","(","2",",","3-dihydroxybenzoyl",")","-L-serine","."),4371297). assertion_content_comment('oboGo_Number23Dihydroxybenzoyladenylatesynthaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxybenzoate","+","ATP","=","2",",","3-dihydroxybenzoyl","5","'","-adenylate","+","diphosphate","."),4251093). assertion_content_comment('oboGo_Number23Dihydroxybiphenyl12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxybiphenyl","+","O2","=","2-hydroxy-6-phenylhexa-2",",","4-dienoic","acid","."),4328932). assertion_content_comment('oboGo_Number23Dihydroxyddt12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxy","DDT","+","O2","=","6-oxo-2-hydroxy-7-","(","4-chlorophenyl",")","-3",",","8",",","8",",","8-tetrachloroocta-2E",",","4E-dienoate","."),4279040). assertion_content_comment('oboGo_Number23Dihydroxydiphenyletherdioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxydiphenyl","ether","+","O2","+","H2O","=","2-hydroxymuconate","+","phenol","."),4348687). assertion_content_comment('oboGo_Number23DihydroxyEthylbenzene12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxyethylbenzene","+","O2","=","H","+","+","2-hydroxy-6-oxoocta-2",",","4-dienoate","."),4278846). assertion_content_comment('oboGo_Number23Dihydroxyindole23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxyindole","+","O","(","2",")","=","anthranilate","+","CO","(","2",")","+","H","(","+",")"),4371309). assertion_content_comment('oboGo_Number23DihydroxyPCumatedioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxy-p-cumate","+","O2","=","2-hydroxy-3-carboxy-6-oxo-7-methylocta-2",",","4-dienoate","."),4278690). assertion_content_comment('oboGo_Number23_Diketo_5_Methylthiopentyl_1_PhosphateEnolaseActivity',s("Catalysis","of","the","reaction",":","2",",","3-diketo-5-methylthiopentyl-1-phosphate","(","DK-MTP-1-P",")","=","H","+","+","2-hydroxy","3-keto-5-methylthiopentenyl-1-phosphate","(","HK-MTPenyl-1-P",")","2",",","3-diketo-5-methylthiopentyl-1-phosphate","is","also","known","as","DK-MTP-1-P",",","and","2-hydroxy","3-keto-5-methylthiopentenyl-1-phosphate","as","HK-MTPenyl-1-P","."),4326315). assertion_content_comment('oboGo_Number23Dimethylmalatelyaseactivity',s("Catalysis","of","the","reaction",":","(","2R",",","3S",")","-2",",","3-dimethylmalate","=","propanoate","+","pyruvate","."),4371319). assertion_content_comment('oboGo_Number244_Trimethyl_1_PentanolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethyl-1-pentanol","=","2",",","4",",","4-trimethylpentanal","+","2","H","+","+","2","e-","."),4350902). assertion_content_comment('oboGo_Number244_Trimethyl_3_Hydroxypentanoyl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethyl-3-hydroxypentanoyl-CoA","=","2",",","4",",","4-trimethyl-3-oxopentanoyl-CoA","+","2","H","+","+","2","e-","."),4350956). assertion_content_comment('oboGo_Number244_Trimethyl_3_OxopentanoateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethyl-3-oxopentanoate","+","H","+","=","2",",","2-dimethyl-3-pentanone","+","CO2","."),4350820). assertion_content_comment('oboGo_Number244_Trimethyl_3_Oxopentanoyl_CoA2_C_PropanoylTransferaseActivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethyl-3-oxopentanoyl-CoA","+","CoASH","=","pivalyl-CoA","+","propanoyl-CoA","."),4350802). assertion_content_comment('oboGo_Number244_Trimethyl_3_Oxopentanoyl_CoAThioesteraseActivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethyl-3-oxopentanoyl-CoA","+","OH-","=","2",",","4",",","4-trimethyl-3-oxopentanoate","+","CoASH","."),4350947). assertion_content_comment('oboGo_Number244_Trimethylpent_2_Enoyl_CoAHydrataseActivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethylpent-2-enoyl-CoA","+","H2O","=","2",",","4",",","4-trimethyl-3-hydroxypentanoyl-CoA","."),4350929). assertion_content_comment('oboGo_Number244Trimethylpentanaldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethylpentanal","+","H2O","=","2",",","4",",","4-trimethylpentanoate","+","3","H","+","+","2","e-","."),4350874). assertion_content_comment('oboGo_Number244TrimethylpentanoateCoaligaseactivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethylpentanoate","+","CoASH","=","2",",","4",",","4-trimethylpentanoyl-CoA","+","OH-","."),4350884). assertion_content_comment('oboGo_Number244TrimethylpentanoylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4",",","4-trimethylpentanoyl-CoA","=","2",",","4",",","4-trimethylpent-2-enoyl-CoA","+","2","H","+","+","2","e-","."),4350938). assertion_content_comment('oboGo_Number245Trichlorophenoxyaceticacidbiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2",",","4",",","5-trichlorophenoxyacetic","acid",",","a","chlorinated","aromatic","compound","widely","used","as","a","herbicide","."),4354234). assertion_content_comment('oboGo_Number245Trichlorophenoxyaceticacidcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2",",","4",",","5-trichlorophenoxyacetic","acid",",","a","chlorinated","aromatic","compound","widely","used","as","a","herbicide","."),4354220). assertion_content_comment('oboGo_Number245Trichlorophenoxyaceticacidmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2",",","4",",","5-trichlorophenoxyacetic","acid",",","a","chlorinated","aromatic","compound","which","is","widely","used","as","a","herbicide",",","often","as","a","weed","killer","for","home","lawns","."),4272910). assertion_content_comment('oboGo_Number245Trichlorophenoxyaceticacidoxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4",",","5-trichlorophenoxyacetic","acid","+","1/2","O2","=","glyoxylate","+","2",",","4",",","5-trichlorophenol","."),4275402). assertion_content_comment('oboGo_Number246Trinitrotoluenebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2",",","4",",","6-trinitrotoluene",",","1-methyl-2",",","4",",","6-trinitrobenzene","."),4353568). assertion_content_comment('oboGo_Number246Trinitrotoluenecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2",",","4",",","6-trinitrotoluene",",","1-methyl-2",",","4",",","6-trinitrobenzene",",","a","highly","explosive","pale","yellow","crystalline","solid","."),4353583). assertion_content_comment('oboGo_Number246Trinitrotoluenemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2",",","4",",","6-trinitrotoluene",",","1-methyl-2",",","4",",","6-trinitrobenzene",",","a","highly","explosive","pale","yellow","crystalline","solid",".","It","is","prepared","from","toluene","treated","with","concentrated","sulfuric","and","nitric","acids","and","is","used","in","shells",",","bombs",",","and","blasting","explosives","."),4272567). assertion_content_comment('oboGo_Number24Diaminopentanoatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4-diaminopentanoate","+","H2O","+","NAD","(","P",")","+","=","2-amino-4-oxopentanoate","+","NH3","+","NAD","(","P",")","H","+","H","+"),4371397). assertion_content_comment('oboGo_Number24Dichloroanilinereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4-dichloroaniline","+","2","H","+","+","2","e-","=","4-chloroaniline","+","HCl","."),4352759). assertion_content_comment('oboGo_Number24Dichlorobenzoatebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2",",","4-dichlorobenzoate",",","a","chlorinated","aromatic","compound","which","is","a","key","intermediate","in","the","aerobic","degradation","of","polychlorinated","biphenyls","(","PCBs",")"),4353102). assertion_content_comment('oboGo_Number24Dichlorobenzoatecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2",",","4-dichlorobenzoate",",","a","chlorinated","aromatic","compound","which","is","a","key","intermediate","in","the","aerobic","degradation","of","polychlorinated","biphenyls","(","PCBs",")"),4353147). assertion_content_comment('oboGo_Number24DichlorobenzoateCoaligaseactivity',s("Catalysis","of","the","reaction",":","2",",","4-dichlorobenzoate","+","ATP","+","CoASH","=","AMP","+","diphosphate","+","2",",","4-dichlorobenzoyl-CoA","."),4273787). assertion_content_comment('oboGo_Number24Dichlorobenzoatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2",",","4-dichlorobenzoate",",","a","chlorinated","aromatic","compound","which","is","a","key","intermediate","in","the","aerobic","degradation","of","polychlorinated","biphenyls","(","PCBs",")"),4273293). assertion_content_comment('oboGo_Number24DichlorobenzoylCoareductaseactivity',s("Catalysis","of","the","reaction",":","4-chlorobenzoyl-CoA","+","chloride","+","NADP","(","+",")","=","2",",","4-dichlorobenzoyl-CoA","+","NADPH","."),4278488). assertion_content_comment('oboGo_Number24Dichlorophenol6Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4-dichlorophenol","+","NADPH","+","H","+","+","O2","=","3",",","5-dichlorocatechol","+","NADP","+","+","H2O","."),4276592). assertion_content_comment('oboGo_Number24DichlorophenoxyacetatealphaKetoglutaratedioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4-dichlorophenoxyacetic","acid","=","glyoxylate","+","2",",","4-dichlorophenol","."),4276964). assertion_content_comment('oboGo_Number24Dichlorophenoxyacetatedehalogenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4-dichlorophenoxyacetic","acid","+","H","+","+","2","e-","=","Cl-","+","4-chlorophenoxyacetate","."),4275292). assertion_content_comment('oboGo_Number24Dichlorophenoxyaceticacidbiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2",",","4-dichlorophenoxyacetic","acid",",","a","chlorinated","phenoxy","compound","which","functions","as","a","systemic","herbicide","and","is","used","to","control","many","types","of","broadleaf","weeds","."),4353132). assertion_content_comment('oboGo_Number24Dichlorophenoxyaceticacidcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2",",","4-dichlorophenoxyacetic","acid",",","a","chlorinated","phenoxy","compound","which","functions","as","a","systemic","herbicide","and","is","used","to","control","many","types","of","broadleaf","weeds","."),4349842). assertion_content_comment('oboGo_Number24Dichlorophenoxyaceticacidmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2",",","4-dichlorophenoxyacetic","acid",",","a","chlorinated","phenoxy","compound","which","functions","as","a","systemic","herbicide","and","is","used","to","control","many","types","of","broadleaf","weeds","."),4272280). assertion_content_comment('oboGo_Number24DienoylCoareductasenadphactivity',s("Catalysis","of","the","reaction",":","trans-2",",","3-didehydroacyl-CoA","+","NADP","+","=","trans",",","trans-2",",","3",",","4",",","5-tetradehydroacyl-CoA","+","NADPH","+","H","+"),4250858). assertion_content_comment('oboGo_Number24_Dihydroxy_6_N_EthylAmino_135_TriazineAminohydrolaseActivity',s("Catalysis","of","the","reaction",":","2",",","4-dihydroxy-6-","(","N","'","-ethyl",")","amino-1",",","3",",","5-triazine","+","H2O","=","CH3CH2NH2","+","cyanuric","acid","."),4274775). assertion_content_comment('oboGo_Number24_Dihydroxy_7_Methoxy_2H_14_Benzoxazin_34H_One2_D_GlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","2",",","4-dihydroxy-7-methoxy-2H-1",",","4-benzoxazin-3","(","4H",")","-one","+","UDP-D-glucose","=","2",",","4-dihydroxy-7-methoxy-2H-1",",","4-benzoxazin-3","(","4H",")","-one","2-D-glucoside","+","UDP","."),4367187). assertion_content_comment('oboGo_Number24Dihydroxyacetophenonedioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4","'","-dihydroxyacetophenone","+","O","(","2",")","=","4-hydroxybenzoate","+","formate","+","2","H","(","+",")"),4365160). assertion_content_comment('oboGo_Number24_Dihydroxyhept_2_Ene_17_DioateAldolaseActivity',s("Catalysis","of","the","reaction",":","2",",","4-dihydroxy-hept-trans-2-ene-1",",","7-dioate","=","pyruvate","+","succinic","semialdehyde","."),4274035). assertion_content_comment('oboGo_Number24Dinitrocyclohexanonehydrolaseactivity',s("Catalysis","of","the","reaction",":","2",",","4-dinitrocyclohexanone","+","OH-","=","4",",","6-dinitrohexanoate","."),4349058). assertion_content_comment('oboGo_Number24Hydroxycholesterol7alphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","(","24R",")","-cholest-5-ene-3beta",",","24-diol","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","(","24R",")","-7alpha",",","24-dihydroxycholesterol","+","H","(","2",")","O","+","NADP","(","+",")"),4342124). assertion_content_comment('oboGo_Number24MethylenesterolcMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","24-methylidenelophenol","+","S-adenosyl-L-methionine","(","1","+",")","=","(","Z",")","-24-ethylidenelophenol","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4308974). assertion_content_comment('oboGo_Number25_Diamino_6_Ribitylamino_43H_Pyrimidinone5_PhosphateDeaminaseActivity',s("Catalysis","of","the","reaction",":","2",",","5-diamino-6-","(","5-phospho-D-ribitylamino",")","pyrimidin-4","(","3H",")","-one","+","H2O","=","5-amino-6-","(","5-phospho-D-ribosylamino",")","uracil","+","ammonia","."),4325789). assertion_content_comment('oboGo_Number25Diaminovaleratetransaminaseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","ornithine","=","5-amino-2-oxopentanoate","+","L-glutamate","."),4371383). assertion_content_comment('oboGo_Number25_Dichloro_25_Cyclohexadiene_14_DiolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2",",","5-dichloro-2",",","5-cyclohexadiene-1",",","4-diol","+","NAD","+","=","NADH","+","H","+","+","2",",","5-dichlorohydroquinone","."),4278633). assertion_content_comment('oboGo_Number25Dichlorohydroquinonereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","organohalide","+","2","H","+","+","2","e-","=","R-H","+","HCl",".","Reactants","include","chlorohydroquinone","(","forms","hydroquinone",")","and","2",",","5-dichlorohydroquinone","(","forms","chlorohydroquinone",")"),4275347). assertion_content_comment('oboGo_Number25Didehydrogluconatereductaseactivity',s("Catalysis","of","the","reaction",":","2-dehydro-D-gluconate","+","NADP","+","=","2",",","5-didehydro-D-gluconate","+","NADPH","+","H","+"),4267885). assertion_content_comment('oboGo_Number25Dihydroxypyridine56Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","H2O","+","O2","+","2",",","5-dihydroxypyridine","=","formate","+","maleamate","."),4365081). assertion_content_comment('oboGo_Number25Dihydroxypyridinecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2",",","5-dihydroxypyridine","."),4242611). assertion_content_comment('oboGo_Number25Dihydroxypyridinecatabolicprocesstofumarate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2",",","5-dihydroxypyridine","to","form","fumarate",".","2",",","5-dihydroxypyridine","is","dioxygenated","to","give","maleamate","and","formate",";","the","maleamate","from","this","reaction","is","then","converted","to","maleate",",","which","is","then","isomerized","to","fumurate","."),4242617). assertion_content_comment('oboGo_Number25Dihydroxypyridinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2",",","5-dihydroxypyridine","."),4242606). assertion_content_comment('oboGo_Number25Dioxopiperazinehydrolaseactivity',s("Catalysis","of","the","reaction",":","2",",","5-dioxopiperazine","+","H","(","2",")","O","=","glycylglycine","."),4371420). assertion_content_comment('oboGo_Number25Dioxovaleratedehydrogenasenadactivity',s("Catalysis","of","the","reaction",":","2",",","5-dioxopentanoate","+","NAD","+","+","H2O","=","2-oxoglutarate","+","NADH","+","H","+"),4288464). assertion_content_comment('oboGo_Number25Dioxovaleratedehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","2",",","5-dioxopentanoate","+","NADP","+","+","H2O","=","2-oxoglutarate","+","NADPH","+","H","+"),4371408). assertion_content_comment('oboGo_Number25_Hydroxycholecalciferol_24_HydroxylaseActivity',s("Catalysis","of","the","hydroxylation","of","C-24","of","25-hydroxycholecalciferol","(","25-hydroxyvitamin","D3",")","to","form","24","(","R",")",",","25-dihydroxycholecalciferol","."),4255807). assertion_content_comment('oboGo_Number25Hydroxycholesterol7alphaHydroxylaseactivity',s("Catalysis","of","the","reactions",":","cholest-5-ene-3beta",",","25-diol","+","NADPH","+","H","+","+","O2","=","cholest-5-ene-3beta",",","7alpha",",","25-triol","+","NADP","+","+","H2O",",","and","cholest-5-ene-3beta",",","27-diol","+","NADPH","+","H","+","+","O2","=","cholest-5-ene-3beta",",","7alpha",",","27-triol","+","NADP","+","+","H2O","."),4342137). assertion_content_comment('oboGo_Number2_5_OligoadenylateSynthetaseActivity',s("Catalysis","of","the","reaction",":","ATP","=","pppA","(","2","'","p5","'","A",")","n","oligomers",".","This","reaction","requires","the","binding","of","double-stranded","RNA","."),4383194). assertion_content_comment('oboGo_Number2_5_RNALigaseActivity',s("Catalysis","of","the","formation","of","a","phosphodiester","bond","between","the","2","'","-hydroxyl","group","at","the","end","of","one","DNA","chain","and","the","5","'","-phosphate","group","at","the","end","of","another","."),4251032). assertion_content_comment('oboGo_Number2_5_Triphosphoribosyl_3_Dephospho_CoABiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2","'","-","(","5","'","'","-triphosphoribosyl",")","-3","'","-dephospho-CoA",",","a","derivative","of","coenzyme","A","."),4239443). assertion_content_comment('oboGo_Number2_5_Triphosphoribosyl_3_Dephospho_CoAMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","2","'","-","(","5","'","'","-triphosphoribosyl",")","-3","'","-dephospho-CoA",",","a","derivative","of","coenzyme","A","."),4239440). assertion_content_comment('oboGo_Number26BetaFructan6Levanbiohydrolaseactivity',s("Catalysis","of","the","hydrolysis","of","2",",","6-beta-D-fructofuranan",",","to","remove","successive","disaccharide","residues","as","levanbiose",",","i.e",".","6-","(","beta-D-fructofuranosyl",")","-D-fructose",",","from","the","end","of","the","chain","."),4344327). assertion_content_comment('oboGo_Number26DichloroPHydroquinone12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","6-dichlorohydroquinone","+","O2","+","H2O","=","HCl","+","2","H","+","+","2-chloromaleylacetate","."),4278719). assertion_content_comment('oboGo_Number26Dihydroxybenzothiazolemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","6-dihydroxybenzothiazole","+","1/2","O2","=","2",",","6",",","7-trihydroxybenzothiazole","."),4350893). assertion_content_comment('oboGo_Number26_Dihydroxycyclohexane_1_Carboxyl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2",",","6-dihydroxycyclohexane-1-carboxyl-CoA","=","2","H","+","+","2","e-","+","6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA","."),4277259). assertion_content_comment('oboGo_Number26Dihydroxypseudooxynicotinehydrolaseactivity',s("Catalysis","of","the","reaction",":","2",",","6-dihydroxypseudooxynicotine","+","H2O","=","2",",","6-dihydroxypyridine","+","4-methylaminobutyrate","."),4348750). assertion_content_comment('oboGo_Number26Dihydroxypyridine3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","6-dihydroxypyridine","+","H","(","+",")","+","NADH","+","O","(","2",")","=","2",",","3",",","6-trihydroxypyridine","+","H","(","2",")","O","+","NAD","(","+",")"),4276529). assertion_content_comment('oboGo_Number26_Dimethyl_5_Methylene_3_Oxo_Heptanoyl_CoAC_AcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","2",",","6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA","+","CoASH","=","3-isopropylbut-3-enoyl-CoA","+","propanoyl-CoA","."),4348805). assertion_content_comment('oboGo_Number26_Dioxo_6_Phenylhexa_3_EnoateHydrolaseActivity',s("Catalysis","of","the","reaction",":","2",",","6-dioxo-6-phenylhexa-3-enoate","+","H2O","=","benzoate","+","2-oxopent-4-enoate","."),4274394). assertion_content_comment('oboGo_Number27Hydroxycholesterol7AlphaMonooxygenaseactivity',s("Catalysis","of","the","reaction",":","O2","+","NADPH","+","27-hydroxycholesterol","=","H2O","+","NADP","+","+","7-alpha",",","27-dihydroxycholesterol","."),4364556). assertion_content_comment('oboGo_Number2Acetamidomethylenesuccinatehydrolaseactivity',s("Catalysis","of","the","reaction",":","2","H2O","+","2-","(","acetamidomethylene",")","succinate","=","CO2","+","NH3","+","succinate","semialdehyde","+","acetate","."),4370088). assertion_content_comment('oboGo_Number2Acetolactatemutaseactivity',s("Catalysis","of","the","reaction",":","2-acetolactate","=","3-hydroxy-3-methyl-2-oxobutanoate","."),4371341). assertion_content_comment('oboGo_Number2_Acylglycerol_3_PhosphateO_AcyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-acyl-sn-glycerol","3-phosphate","+","acyl-CoA","=","L-phosphatidate","+","CoA","."),4365552). assertion_content_comment('oboGo_Number2AcylglyceroloAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","2-acylglycerol","=","CoA","+","diacylglycerol","."),4188992). assertion_content_comment('oboGo_Number2AcylglycerophosphocholineoAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","2-acyl-sn-glycero-3-phosphocholine","+","acyl-CoA","=","1",",","2-diacyl-sn-glycero-3-phosphocholine","+","CoA","."),4366087). assertion_content_comment('oboGo_Number2Alkenalreductaseactivitynadpactivity',s("Catalysis","of","the","reaction",":","n-alkanal","+","NADP","+","=","alk-2-enal","+","NADPH","+","H","+"),4381275). assertion_content_comment('oboGo_Number2Alkenalreductaseactivity',s("Catalysis","of","the","reaction",":","n-alkanal","+","NAD","(","P",")","+","=","alk-2-enal","+","NAD","(","P",")","H","+","H","+"),4334846). assertion_content_comment('oboGo_Number2_Alkyn_1_OlDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2-butyne-1",",","4-diol","+","NAD","(","+",")","=","4-hydroxy-2-butynal","+","H","(","+",")","+","NADH","."),4371331). assertion_content_comment('oboGo_Number2AlphaHydroxytaxane2OBenzoyltransferaseactivity',s("Catalysis","of","the","reaction",":","10-deacetyl-2-debenzoylbaccatin","III","+","benzoyl-CoA","=","10-deacetylbaccatin","III","+","CoA","."),4277679). assertion_content_comment('oboGo_Number2_Amino_4_Hydroxy_6_HydroxymethyldihydropteridineDiphosphokinaseActivity',s("Catalysis","of","the","reaction",":","2-amino-4-hydroxy-6-hydroxymethyl-7",",","8-dihydropteridine","+","ATP","=","(","2-amino-4-hydroxy-7",",","8-dihydropteridin-6-yl",")","methyl","diphosphate","+","AMP","+","2","H","(","+",")"),4189053). assertion_content_comment('oboGo_Number2_Amino_5_Formylamino_6_5_PhosphoribosylaminoPyrimidin_43H_OneFormate_LyaseActivity',s("Catalysis","of","the","reaction",":","2-amino-5-formylamino-6-","(","5-phosphoribosylamino",")","pyrimidin-4","(","3H",")","-one","+","H2O","=","2",",","5-diamino-6-","(","5-phosphoribosylamino",")","pyrimidin-4","(","3H",")","-one","+","formate","."),4325830). assertion_content_comment('oboGo_Number2Aminoadipatetransaminaseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","L-2-aminoadipate","=","2-oxoadipate","+","L-glutamate","."),4371368). assertion_content_comment('oboGo_Number2Aminobenzenesulfonate23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2-aminobenzenesulfonate","+","2","H","(","+",")","+","NADH","+","O","(","2",")","=","2",",","3-dihydroxybenzenesulfonate","+","NAD","(","+",")","+","NH","(","4",")","(","+",")","2",",","3-dihydroxybenzenesulfonate","is","also","known","as","3-sulfocatechol","."),4276037). assertion_content_comment('oboGo_Number2Aminobenzenesulfonatebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2-aminobenzenesulfonate",",","an","aromatic","sulfonate","used","in","organic","synthesis","and","in","the","manufacture","of","various","dyes","and","medicines","."),4353985). assertion_content_comment('oboGo_Number2Aminobenzenesulfonatecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2-aminobenzenesulfonate",",","an","aromatic","sulfonate","used","in","organic","synthesis","and","in","the","manufacture","of","various","dyes","and","medicines","."),4354019). assertion_content_comment('oboGo_Number2Aminobenzenesulfonatedesulfonation',s("The","removal","of","the","sulfonate","group","from","2-aminobenzenesulfonate",",","an","aromatic","sulfonate","used","in","organic","synthesis","and","in","the","manufacture","of","various","dyes","and","medicines","."),4240949). assertion_content_comment('oboGo_Number2Aminobenzenesulfonatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2-aminobenzenesulfonate",",","aniline-o-sulfonic","acid",",","an","aromatic","sulfonate","used","in","organic","synthesis","and","in","the","manufacture","of","various","dyes","and","medicines","."),4240944). assertion_content_comment('oboGo_Number2AminobenzoylCoareductaseactivity',s("Catalysis","of","the","reaction",":","2-aminobenzoyl-CoA","+","2","H","+","+","2","e-","=","NH3","+","benzoyl-CoA","."),4278371). assertion_content_comment('oboGo_Number2_Aminobiphenyl_23_Diol12_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","2","'","-aminobiphenyl-2",",","3-diol","+","O2","=","H","+","+","2-hydroxy-6-oxo-","(","2","'","-aminophenyl",")","-hexa-2",",","4-dienoate","."),4278800). assertion_content_comment('oboGo_Number2Aminoethylphosphonatebinding',s("Interacting","selectively","and","non-covalently","with","2-aminoethylphosphonate","."),4338129). assertion_content_comment('oboGo_Number2Aminoethylphosphonatecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2-aminoethylphosphonate",",","also","known","as","ciliatine","."),4244094). assertion_content_comment('oboGo_Number2Aminoethylphosphonatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2-aminoethylphosphonate",",","most","abundant","and","ubiquitous","of","naturally","occurring","phosphonates",".","It","is","typically","found","as","a","conjugate","of","glycans",",","lipids",",","and","proteins",",","which","in","turn","perform","essential","biochemical","functions","in","specialized","lower","organisms","."),4244087). assertion_content_comment('oboGo_Number2AminoethylphosphonatePyruvatetransaminaseactivity',s("Catalysis","of","the","reaction",":","(","2-aminoethyl",")","phosphonate","+","pyruvate","=","L-alanine","+","phosphonoacetaldehyde","."),4369165). assertion_content_comment('oboGo_Number2Aminoethylphosphonatetransmembranetransporteractivity',s("Enables","the","directed","movement","of","2-aminoethylphosphonate","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4338114). assertion_content_comment('oboGo_Number2Aminoethylphosphonatetransportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","2-aminoethylphosphonate","(","out",")","=","ADP","+","phosphate","+","2-aminoethylphosphonate","(","in",")"),4338118). assertion_content_comment('oboGo_Number2Aminoethylphosphonatetransport',s("The","directed","movement","of","2-aminoethylphosphonate",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4338141). assertion_content_comment('oboGo_Number2_Aminohexano_6_LactamRacemaseActivity',s("Catalysis","of","the","reaction",":","L-2-aminohexano-6-lactam","=","D-2-aminohexano-6-lactam","."),4369593). assertion_content_comment('oboGo_Number2Aminohexanoatetransaminaseactivity',s("Catalysis","of","the","reaction",":","L-2-aminohexanoate","+","2-oxoglutarate","=","2-oxohexanoate","+","L-glutamate","."),4371353). assertion_content_comment('oboGo_Number2Aminomuconatedeaminaseactivity',s("Catalysis","of","the","reaction",":","2-aminomuconate","+","H","(","2",")","O","+","H","(","+",")","=","(","Z",")","-5-oxohex-2-enedioate","+","NH","(","4",")","(","+",")"),4268782). assertion_content_comment('oboGo_Number2Aminophenol16Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2-aminophenol","+","O2","=","2-aminomuconic","semialdehyde","."),4278710). assertion_content_comment('oboGo_Number2Butanoneoxidaseactivity',s("Catalysis","of","the","reaction",":","methyl","ethyl","ketone","+","O2","=","H2O","+","ethyl","acetate","."),4277080). assertion_content_comment('oboGo_Number2_Carboxy_2_Hydroxy_8_CarboxychromeneIsomeraseActivity',s("Catalysis","of","the","reaction",":","2-carboxy-2-hydroxy-8-carboxychromene","=","2-hydroxy-3-carboxybenzalpyruvate","."),4352219). assertion_content_comment('oboGo_Number2Carboxybenzaldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-carboxybenzaldehyde","+","NAD","+","+","H2O","=","NADH","+","2","H","+","+","phthalate","."),4277502). assertion_content_comment('oboGo_Number2_Carboxy_D_Arabinitol_1_PhosphataseActivity',s("Catalysis","of","the","reaction",":","2-carboxy-D-arabinitol","1-phosphate","+","H","(","2",")","O","=","2-carboxy-D-arabinitol","+","phosphate","."),4371158). assertion_content_comment('oboGo_Number2_Chloro_46_Dihydroxy_135_TriazineHydrolaseActivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4274425). assertion_content_comment('oboGo_Number2_Chloro_4_Carboxymethylenebut_2_En_14_OlideIsomeraseActivity',s("Catalysis","of","the","reaction",":","cis-2-chloro-4-carboxymethylenebut-2-en-1",",","4-olide","=","trans-2-chloro-4-carboxymethylenebut-2-en-1",",","4-olide","."),4369510). assertion_content_comment('oboGo_Number2_Chloro_4_Hydroxy_6_Amino_135_TriazineAminohydrolaseActivity',s("Catalysis","of","the","reaction",":","2-chloro-4-hydroxy-6-amino-1",",","3",",","5-triazine","+","OH-","=","2",",","4-dihydroxy-6-amino-1",",","3",",","5-triazine","+","Cl-","."),4274784). assertion_content_comment('oboGo_Number2Chlorobenzoate12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2-chlorobenzoate","+","NADH","+","H","+","+","O2","=","catechol","+","chloride","+","NAD","+","+","CO2","."),4276052). assertion_content_comment('oboGo_Number2ChloroNIsopropylacetanilide12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2-chloro-N-isopropylacetanilide","+","O2","+","2","H","+","+","NADH","=","2-chloro-N-isopropylacetamide","+","catechol","+","NAD","+"),4350223). assertion_content_comment('oboGo_Number2ChloroNIsopropylacetanilidebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2-chloro-N-isopropylacetanilide",",","an","acylanide","herbicide","widely","used","to","protect","corn",",","onion",",","cabbage",",","rose","bushes",",","and","ornamental","plants","."),4349866). assertion_content_comment('oboGo_Number2ChloroNIsopropylacetanilidecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2-chloro-N-isopropylacetanilide",",","an","acylanide","herbicide","widely","used","to","protect","corn",",","onion",",","cabbage",",","rose","bushes",",","and","ornamental","plants","."),4349890). assertion_content_comment('oboGo_Number2ChloroNIsopropylacetanilidemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2-chloro-N-isopropylacetanilide",",","an","acylanide","herbicide","widely","used","to","protect","corn",",","onion",",","cabbage",",","rose","bushes",",","and","ornamental","plants","."),4273374). assertion_content_comment('oboGo_Number2ChloroNIsopropylacetanilidereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","2-chloro-N-isopropylacetanilide","+","H","+","+","2","e-","=","Cl-","+","N-isopropylacetanilide","."),4275338). assertion_content_comment('oboGo_Number2CMethylDErythritol24Cyclodiphosphatesynthaseactivity',s("Catalysis","of","the","reaction",":","4-CDP-2-C-methyl-D-erythritol","2-phosphate","=","2-C-methyl-D-erythritol","2",",","4-cyclic","diphosphate","+","CMP","."),4251247). assertion_content_comment('oboGo_Number2CMethylDErythritol4Phosphatecytidylyltransferaseactivity',s("Catalysis","of","the","reaction",":","2-C-methyl-D-erythritol","4-phosphate","+","CTP","=","4-CDP-2-C-methyl-D-erythritol","+","diphosphate","."),4269027). assertion_content_comment('oboGo_Number2CoumarateoBetaGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","trans-2-coumarate","+","UDP-D-glucose","=","trans-beta-D-glucosyl-2-hydroxycinnamate","+","H","(","+",")","+","UDP","."),4366657). assertion_content_comment('oboGo_Number2Coumaratereductaseactivity',s("Catalysis","of","the","reaction",":","3-","(","2-hydroxyphenyl",")","propanoate","+","NAD","(","+",")","=","trans-2-coumarate","+","H","(","+",")","+","NADH","."),4373833). assertion_content_comment('oboGo_Number2_Decaprenyl_6_Methoxy_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-decaprenyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-methionine","=","2-decaprenyl-3-methyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-homocysteine","."),4324923). assertion_content_comment('oboGo_Number2_Dehydro_3_Deoxy_6_PhosphogalactonateAldolaseActivity',s("Catalysis","of","the","reaction",":","6-phospho-2-dehydro-3-deoxy-D-galactonate","=","D-glyceraldehyde","3-phosphate","+","pyruvate","."),4250938). assertion_content_comment('oboGo_Number2_Dehydro_3_Deoxy_D_Gluconate5_DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","+","+","2-dehydro-3-deoxy-D-gluconate","=","NADH","+","(","4S",")","-4",",","6-dihydroxy-2",",","5-dioxohexanoate","."),4364520). assertion_content_comment('oboGo_Number2_Dehydro_3_Deoxy_D_Gluconate6_DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-3-deoxy-D-gluconate","+","NADP","(","+",")","=","(","4S",",","5S",")","-4",",","5-dihydroxy-2",",","6-dioxohexanoate","+","H","(","+",")","+","NADPH","."),4364534). assertion_content_comment('oboGo_Number2_Dehydro_3_Deoxy_D_PentonateAldolaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-3-deoxy-D-arabinonate","=","glycolaldehyde","+","pyruvate","."),4370128). assertion_content_comment('oboGo_Number2_Dehydro_3_DeoxygalactonokinaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-3-deoxy-D-galactonate","+","ATP","=","6-phospho-2-dehydro-3-deoxy-D-galactonate","+","ADP","+","2","H","(","+",")"),4250843). assertion_content_comment('oboGo_Number2_Dehydro_3_DeoxyglucarateAldolaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-3-deoxy-D-glucarate","=","pyruvate","+","tartronate","semialdehyde","."),4250828). assertion_content_comment('oboGo_Number2_Dehydro_3_DeoxygluconokinaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-3-deoxy-D-gluconate","+","ATP","=","2-dehydro-3-deoxy-6-phospho-D-gluconate","+","ADP","+","2","H","(","+",")"),4250810). assertion_content_comment('oboGo_Number2_Dehydro_3_Deoxy_L_ArabinonateDehydrataseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-3-deoxy-L-arabinonate","=","2",",","5-dioxopentanoate","+","H","(","2",")","O","."),4370201). assertion_content_comment('oboGo_Number2_Dehydro_3_Deoxy_L_PentonateAldolaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-3-deoxy-L-pentonate","=","glycolaldehyde","+","pyruvate","."),4370361). assertion_content_comment('oboGo_Number2_Dehydro_3_Deoxy_PhosphogluconateAldolaseActivity',s("Catalysis","of","the","reaction",":","2-dehydro-3-deoxy-D-gluconate","6-phosphate","=","pyruvate","+","D-glyceraldehyde","3-phosphate","."),4250914). assertion_content_comment('oboGo_Number2Dehydropantoate2Reductaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-pantoate","+","NADP","(","+",")","=","2-dehydropantoate","+","H","(","+",")","+","NADPH","."),4250873). assertion_content_comment('oboGo_Number2Dehydropantoatealdolaseactivity',s("Catalysis","of","the","reaction",":","2-dehydropantoate","=","3-methyl-2-oxobutanoate","+","formaldehyde","."),4270025). assertion_content_comment('oboGo_Number2DehydropantolactonereductaseaSpecificactivity',s("Catalysis","of","the","reaction",":","(","R",")","-pantolactone","+","NADP","+","=","2-dehydropantolactone","+","NADPH","+","H","+","The","reaction","is","A-specific","(","i.e",".","the","pro-R","hydrogen","is","transferred","from","the","4-position","of","reduced","nicotinamide","cofactor",")","with","respect","to","NADP","+"),4364024). assertion_content_comment('oboGo_Number2DehydropantolactonereductasebSpecificactivity',s("Catalysis","of","the","reaction",":","(","R",")","-pantolactone","+","NADP","+","=","2-dehydropantolactone","+","NADPH","+","H","+","The","reaction","is","B-specific","(","i.e",".","the","pro-S","hydrogen","is","transferred","from","the","4-position","of","reduced","nicotinamide","cofactor",")","with","respect","to","NADP","+"),4237516). assertion_content_comment('oboGo_Number2DeoxyDGluconate3Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-deoxy-D-gluconate","+","NAD","+","=","3-dehydro-2-deoxy-D-gluconate","+","NADH","+","H","+"),4250971). assertion_content_comment('oboGo_Number2_Deoxyglucose_6_PhosphataseActivity',s("Catalysis","of","the","reaction",":","2-deoxy-D-glucose-6-phosphate","+","H2O","=","2-deoxy-D-glucose","+","phosphate","."),4188914). assertion_content_comment('oboGo_Number2Deoxyglucosidaseactivity',s("Catalysis","of","the","reaction",":","H2O","+","a","2-deoxy-alpha-D-glucoside","=","2-deoxy-D-glucose","+","an","alcohol","."),4371170). assertion_content_comment('oboGo_Number2DeoxymugineicAcid2Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2","'","-deoxymugineate","+","2-oxoglutarate","+","O","(","2",")","=","CO","(","2",")","+","H","(","+",")","+","mugineate","+","succinate","."),4342701). assertion_content_comment('oboGo_Number2Deoxyribonucleotidebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","2","'","-deoxyribonucleotide",",","a","compound","consisting","of","2","'","-deoxyribonucleoside","(","a","base","linked","to","a","2","'","-deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222903). assertion_content_comment('oboGo_Number2Deoxyribonucleotidemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","a","2","'","-deoxyribonucleotide",",","a","compound","consisting","of","2","'","-deoxyribonucleoside","(","a","base","linked","to","a","2","'","-deoxyribose","sugar",")","esterified","with","a","phosphate","group","at","either","the","3","'","or","5","'","-hydroxyl","group","of","the","sugar","."),4222874). assertion_content_comment('oboGo_Number2Deoxyribose1Phosphatebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2-deoxyribose","1-phosphate",",","the","phosphorylated","sugar","1-phospho-2-deoxyribose","."),4225363). assertion_content_comment('oboGo_Number2Deoxyribose1Phosphatecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","deoxyribose","1-phosphate",",","the","phosphorylated","sugar","1-phospho-2-deoxyribose","."),4225419). assertion_content_comment('oboGo_Number2Deoxyribose1Phosphatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2-deoxyribose","1-phosphate",",","the","phosphorylated","sugar","1-phospho-2-deoxyribose","."),4225342). assertion_content_comment('oboGo_Number2Enoatereductaseactivity',s("Catalysis","of","the","reaction",":","butanoate","+","NAD","+","=","2-butenoate","+","NADH","+","H","+"),4371286). assertion_content_comment('oboGo_Number2Ethylmalatesynthaseactivity',s("Catalysis","of","the","reaction",":","2-oxobutanate","+","acetyl-CoA","+","H","(","2",")","O","=","(","R",")","-2-ethylmalate","+","CoA","+","H","(","+",")"),4266975). assertion_content_comment('oboGo_Number2Fe_2SElectronTransferCarrier',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259451). assertion_content_comment('oboGo_Number2FuroateCoaligaseactivity',s("Catalysis","of","the","reaction",":","2-furoate","+","ATP","+","CoA","=","2-furoyl-CoA","+","AMP","+","diphosphate","+","H","(","+",")"),4371274). assertion_content_comment('oboGo_Number2FuroylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-furoyl-CoA","+","A","+","H","(","2",")","O","=","5-hydroxy-2-furoyl-CoA","+","AH","(","2",")","+","H","(","+",")"),4371260). assertion_content_comment('oboGo_Number2HaloaciddehalogenaseconfigurationInvertingactivity',s("Catalysis","of","the","reactions",":","(","S",")","-2-haloacid","+","H2O","=","(","R",")","-2-hydroxyacid","+","halide",",","and","(","R",")","-2-haloacid","+","H2O","=","(","S",")","-2-hydroxyacid","+","halide","."),4344996). assertion_content_comment('oboGo_Number2HaloaciddehalogenaseconfigurationRetainingactivity',s("Catalysis","of","the","reactions",":","(","S",")","-2-haloacid","+","H2O","=","(","S",")","-2-hydroxyacid","+","halide",",","and","(","R",")","-2-haloacid","+","H2O","=","(","R",")","-2-hydroxyacid","+","halide","."),4345011). assertion_content_comment('oboGo_Number2_Heptaprenyl_6_Methoxy_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-heptaprenyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-methionine","=","2-heptaprenyl-3-methyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-homocysteine","."),4324934). assertion_content_comment('oboGo_Number2Hexadecenalreductaseactivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","palmitaldehyde","=","trans-hexadec-2-enal","+","H","(","+",")","+","NADPH","."),4371249). assertion_content_comment('oboGo_Number2_Hexaprenyl_6_Methoxy_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-hexaprenyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-methionine","=","2-hexaprenyl-3-methyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-homocysteine","."),4318250). assertion_content_comment('oboGo_Number2_Hydroxy_14_BenzoquinoneReductaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-1",",","4-benzoquinone","+","2","H","(","+",")","+","NADH","=","benzene-1",",","2",",","4-triol","+","NAD","(","+",")"),4277955). assertion_content_comment('oboGo_Number2_Hydroxy_2H_BenzoHChromene_2_CarboxylateIsomeraseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-2","H-benzo","[","h","]","chromene-2-carboxylate","=","cis","-4-","(","1","'","-hydroxynaphth-2","'","-yl",")","-2-oxobut-3-enoate","."),4273493). assertion_content_comment('oboGo_Number2_Hydroxy_2_Methyl_13_DicarbonateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-2-methyl-1",",","3-dicarbonate","+","H","+","=","CO2","+","L-lactate","."),4274167). assertion_content_comment('oboGo_Number2_Hydroxy_3_Carboxy_6_Oxo_7_Methylocta_24_DienoateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-3-carboxy-6-oxo-7-methylocta-2",",","4-dienoate","=","CO2","+","2-hydroxy-6-oxo-7-methylocta-2",",","4-dienoate","."),4274188). assertion_content_comment('oboGo_Number2_Hydroxy_3_Carboxy_BenzalpyruvateHydratase_AldolaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-3-carboxybenzalpyruvate","+","H2O","=","3-formylsalicylic","acid","+","pyruvate","."),4352237). assertion_content_comment('oboGo_Number2_Hydroxy_3_Keto_5_Methylthiopentenyl_1_PhosphatePhosphataseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate","+","H2O","=","1",",","2-dihydroxy-5-","(","methylthio",")","pent-1-en-3-one","+","phosphate",".","2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate","is","also","known","as","HK-MTPenyl-P",",","and","1",",","2-dihydroxy-3-keto-5-methylthiopentene","as","DHK-MTPene","."),4326329). assertion_content_comment('oboGo_Number2_Hydroxy_3_MethylbenzalpyruvateHydratase_AldolaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-3-methylbenzalpyruvate","+","H2O","=","pyruvate","+","3-methylsalicylaldehyde","."),4352714). assertion_content_comment('oboGo_Number2_Hydroxy_3_OxoadipateSynthaseActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","glyoxylate","+","H","(","+",")","=","2-hydroxy-3-oxoadipate","+","CO","(","2",")"),4266948). assertion_content_comment('oboGo_Number2_Hydroxy_3_OxopropionateReductaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-glycerate","+","NADP","+","=","2-hydroxy-3-oxopropanoate","+","NADPH","+","H","+"),4250959). assertion_content_comment('oboGo_Number2_Hydroxy_4_HydroxymethylbenzalpyruvateHydratase_AldolaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-4-hydroxymethylbenzalpyruvate","+","H2O","=","pyruvate","+","4-hydroxymethylsalicylaldehyde","."),4352156). assertion_content_comment('oboGo_Number2_Hydroxy_4_Isopropenylcyclohexane_1_Carboxyl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA","=","4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA","+","2","H","+","+","2","e-","."),4349776). assertion_content_comment('oboGo_Number2_Hydroxy_6_Ketonona_24_DienedoicAcidHydrolaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-6-keto-nona-2",",","4-dienedioate","+","OH-","=","cis-2-hydroxypenta-2",",","4-dienoate","+","succinate","."),4274343). assertion_content_comment('oboGo_Number2_Hydroxy_6_Oxo_6_2_AminophenylHexa_24_DienoateHydrolaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-6-oxo-","(","2","'","-aminophenyl",")","-hexa-2",",","4-dienoate","+","H2O","=","2-aminobenzoate","+","cis-2-hydroxypenta-2",",","4-dienoate","."),4274621). assertion_content_comment('oboGo_Number2_Hydroxy_6_Oxo_6_2_Carboxyphenyl_Hexa_24_DienoateHydrolaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-6-oxo-6-","(","2-carboxyphenyl",")","-hexa-2",",","4-dienoate","+","H2O","=","cis-2-hydroxypenta-2",",","4-dienoate","+","phthalate","+","H","+"),4349978). assertion_content_comment('oboGo_Number2_Hydroxy_6_Oxo_6_Phenylhexa_24_DienoateReductaseActivity',s("Catalysis","of","the","reaction",":","2",",","6-dioxo-6-phenylhexanoate","+","NADP","(","+",")","=","2-hydroxy-6-oxo-6-phenylhexa-2",",","4-dienoate","+","H","(","+",")","+","NADPH","."),4365859). assertion_content_comment('oboGo_Number2_Hydroxy_6_Oxo_7_Methylocta_24_DienoateHydrolaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-6-oxo-7-methylocta-2",",","4-dienoate","+","H2O","=","cis-2-hydroxypenta-2",",","4-dienoate","+","isobutyrate","."),4274630). assertion_content_comment('oboGo_Number2_Hydroxy_6_Oxohepta_24_DienoateHydrolaseActivity',s("Catalysis","of","the","reaction",":","cis",",","cis-2-hydroxy-6-oxohept-2",",","4-dienoate","+","OH-","=","cis-2-hydroxypenta-2",",","4-dienoate","+","acetate","."),4274648). assertion_content_comment('oboGo_Number2_Hydroxy_6_Oxoocta_24_DienoateHydrolaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-6-oxoocta-2",",","4-dienoate","+","H2O","=","H","+","+","propanoate","+","cis-2-hydroxypenta-2",",","4-dienoate","."),4274657). assertion_content_comment('oboGo_Number2_Hydroxy_7_Hydroxymethylchromene_2_CarboxylateIsomeraseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-7-hydroxymethylchromene-2-carboxylate","=","2-hydroxy-4-hydroxymethylbenzalpyruvate","."),4352165). assertion_content_comment('oboGo_Number2_Hydroxy_8_Methylchromene_2_CarboxylateIsomeraseActivity',s("Catalysis","of","the","reaction",":","2-hydroxy-8-methylchromene-2-carboxylate","=","2-hydroxy-3-methylbenzalpyruvate","."),4352705). assertion_content_comment('oboGo_Number2Hydroxyacylsphingosine1BetaGalactosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-galactose","+","2-","(","2-hydroxyacyl",")","sphingosine","=","UDP","+","1-","(","beta-D-galactosyl",")","-2-","(","2-hydroxyacyl",")","sphingosine","."),4188925). assertion_content_comment('oboGo_Number2Hydroxybenzothiazolemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxybenzothiazole","+","1/2","O2","=","2",",","6-dihydroxybenzothiazole","."),4350838). assertion_content_comment('oboGo_Number2_Hydroxybiphenyl_2_SulfinateDesulfinaseActivity',s("Catalysis","of","the","reaction",":","2","'","-hydroxybiphenyl-2-sulfinate","+","H","(","2",")","O","=","biphenyl-2-ol","+","sulfite","."),4274918). assertion_content_comment('oboGo_Number2Hydroxybiphenyl3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","biphenyl-2-ol","+","H","(","+",")","+","NADH","+","O","(","2",")","=","biphenyl-2",",","3-diol","+","H","(","2",")","O","+","NAD","(","+",")"),4371239). assertion_content_comment('oboGo_Number2_Hydroxy_But_3_EnylGlucosinolateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","progoitrin",",","a","2-hydroxy-but-3-enyl","glucosinolate",".","Glucosinolates","are","substituted","thioglucosides","found","in","rapeseed","products","and","related","cruciferae",",","and","progoitrin","has","been","implicated","in","causing","goiters","in","mammals","and","bitter","taste","in","cruciferous","vegetables","."),4181896). assertion_content_comment('oboGo_Number2_Hydroxychromene_2_CarboxylateIsomeraseActivity',s("Catalysis","of","the","reaction",":","2-hydroxychromene-2-carboxylate","=","(","3E",")","-4-","(","2-hydroxyphenyl",")","-2-oxobut-3-enoate",".","(","3E",")","-4-","(","2-hydroxyphenyl",")","-2-oxobut-3-enoate","is","also","known","as","trans-o-hydroxybenzylidenepyruvate","."),4273839). assertion_content_comment('oboGo_Number2_Hydroxycyclohexane_1_Carboxyl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2-hydroxycyclohexane-1-carboxyl-CoA","=","2","H","+","+","2","e-","+","2-ketocyclohexane-1-carboxyl-CoA","."),4277268). assertion_content_comment('oboGo_Number2Hydroxycyclohexanone2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxycyclohexan-1-one","+","NADPH","+","O","(","2",")","=","6-oxohexanoate","+","H","(","2",")","O","+","NADP","(","+",")"),4364610). assertion_content_comment('oboGo_Number2Hydroxydaidzeinreductaseactivity',s("Catalysis","of","the","reaction",":","2","'","-hydroxydihydrodaidzein","+","NADP","+","=","2","'","-hydroxydaidzein","+","NADPH","+","H","+"),4371527). assertion_content_comment('oboGo_Number2_Hydroxydec_24_Diene_110_DioateHydrataseActivity',s("Catalysis","of","the","reaction",":","2-hydroxydec-2",",","4-diene-1",",","10-dioate","+","H2O","=","(","2Z",")","-2",",","4-dihydroxydec-2-enedioate","."),4350556). assertion_content_comment('oboGo_Number2Hydroxyglutaratedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-2-hydroxyglutarate","+","acceptor","=","2-oxoglutarate","+","reduced","acceptor","."),4371221). assertion_content_comment('oboGo_Number2Hydroxyglutaratesynthaseactivity',s("Catalysis","of","the","reaction",":","glyoxylate","+","H","(","2",")","O","+","propanoyl-CoA","=","2-hydroxyglutarate","+","CoA","+","H","(","+",")"),4237405). assertion_content_comment('oboGo_Number2HydroxyglutarylCoadehydrataseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-2-hydroxyglutaryl-CoA","=","H2O","+","glutaconyl-CoA","."),4326341). assertion_content_comment('oboGo_Number2_Hydroxyhexa_24_DienoateHydrataseActivity',s("Catalysis","of","the","reaction",":","(","2E",",","4E",")","-2-hydroxyhexa-2",",","4-dienoate","+","H2O","=","4-hydroxy-2-oxohexanoate","."),4350856). assertion_content_comment('oboGo_Number2Hydroxyisobutyrate3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxyisobutyrate","+","1/2","O2","=","2",",","3-dihydroxy-2-methyl","propionate","."),4275598). assertion_content_comment('oboGo_Number2Hydroxyisobutyratedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxyisobutyrate","+","H","+","=","CO2","+","2-propanol","."),4274158). assertion_content_comment('oboGo_Number2Hydroxyisobutyratedehydrataseactivity',s("Catalysis","of","the","reaction",":","2-hydroxyisobutyrate","=","H2O","+","methacrylate","."),4273949). assertion_content_comment('oboGo_Number2HydroxyisocaproatecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","2-oxoisocaproate","+","CoA","=","(","R",")","-2-hydroxyisocaproyl-CoA","."),4326281). assertion_content_comment('oboGo_Number2Hydroxyisoflavanonedehydrataseactivity',s("Catalysis","of","the","reaction",":","2",",","7",",","4","'","-trihydroxyisoflavanone","=","daidzein","+","H2O","."),4345311). assertion_content_comment('oboGo_Number2Hydroxyisoflavanonesynthaseactivity',s("Catalysis","of","the","reaction",":","apigenin","+","2","NADPH","+","2","H","+","+","O2","=","2-hydroxy-2",",","3-dihydrogenistein","+","2","NADP","+","+","H2O","."),4342254). assertion_content_comment('oboGo_Number2Hydroxyisoflavonereductaseactivity',s("Catalysis","of","the","reaction",":","vestitone","+","NADP","+","=","2","'","-hydroxyformononetin","+","NADPH","+","H","+"),4371542). assertion_content_comment('oboGo_Number2Hydroxyisonicotinatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxyisonicotinate","+","acceptor","+","H2O","=","citrazinate","+","reduced","acceptor","."),4351037). assertion_content_comment('oboGo_Number2Hydroxyisophthalatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxyisophthalic","acid","=","salicylate","+","CO2","."),4352082). assertion_content_comment('oboGo_Number2Hydroxylaminobenzoatereductaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxylaminobenzoate","+","NAD","(","P",")","H","=","anthranilate","+","NAD","(","P",")","+","+","H2O","."),4352831). assertion_content_comment('oboGo_Number2_Hydroxymethyl_3_AcetamidomethyleneSuccinateHydrolaseActivity',s("Catalysis","of","the","reaction",":","(","2Z",")","-2-","(","acetamidomethylene",")","-3-","(","hydroxymethyl",")","succinate","+","2","H","(","2",")","O","+","H","(","+",")","=","2-","(","hydroxymethyl",")","-4-oxobutanoate","+","acetate","+","CO","(","2",")","+","NH","(","4",")","(","+",")"),4370016). assertion_content_comment('oboGo_Number2Hydroxymethylglutaratedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-","(","hydroxymethyl",")","glutarate","+","NAD","(","+",")","=","2-formylglutarate","+","H","(","+",")","+","NADH","."),4326260). assertion_content_comment('oboGo_Number2HydroxymuconateSemialdehydehydrolaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxymuconate","semialdehyde","+","H2O","=","formate","+","2-oxopent-4-enoate","."),4274380). assertion_content_comment('oboGo_Number2HydroxyPhenylacetatehydroxylaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxyphenylacetate","+","NADH","+","O2","=","NAD","+","+","OH-","+","homogentisate","."),4276231). assertion_content_comment('oboGo_Number2HydroxypropylComlyaseactivity',s("Catalysis","of","the","reactions",":","(","R",")","-2-hydroxypropyl-CoM","=","H-S-CoM","+","(","R",")","-1",",","2-epoxypropane",",","and","(","S",")","-2-hydroxypropyl-CoM","=","H-S-CoM","+","(","S",")","-1",",","2-epoxypropane","."),4268111). assertion_content_comment('oboGo_Number2Hydroxypyridine5Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxypyridine","+","AH","(","2",")","+","O","(","2",")","=","2",",","5-dihydroxypyridine","+","A","+","H","(","2",")","O","."),4371209). assertion_content_comment('oboGo_Number2Hydroxyquinoline56Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","quinolin-2-ol","+","NADH","+","H","+","+","O2","=","2",",","5",",","6-trihydroxy-5",",","6-dihydroquinoline","+","NAD","+"),4276011). assertion_content_comment('oboGo_Number2Hydroxyquinoline8Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADH","+","O","(","2",")","+","quinolin-2-ol","=","H","(","2",")","O","+","NAD","(","+",")","+","quinoline-2",",","8-diol","."),4342185). assertion_content_comment('oboGo_Number2Hydroxytetrahydrofurandehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxytetrahydrofuran","=","2","H","+","+","2","e-","+","butyrolactone","."),4281729). assertion_content_comment('oboGo_Number2Hydroxytetrahydrofuranisomeraseactivity',s("Catalysis","of","the","reaction",":","2-hydroxytetrahydrofuran","=","4-hydroxybutyraldehyde","."),4273830). assertion_content_comment('oboGo_Number2Indanonemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","2-indanone","+","NADPH","+","1/2","O2","=","NADP","+","+","3-isochromanone","."),4276907). assertion_content_comment('oboGo_Number2Isopropylmalatesynthaseactivity',s("Catalysis","of","the","reaction",":","3-methyl-2-oxobutanoate","+","acetyl-CoA","+","H","(","2",")","O","=","(","2S",")","-2-isopropylmalate","+","CoA","+","H","(","+",")"),4188954). assertion_content_comment('oboGo_Number2_Keto_3_DeoxygalactonateAldolaseActivity',s("Catalysis","of","the","reaction",":","2-keto-3-deoxygalactonate","=","D-glyceraldehyde","+","pyruvate","."),4325777). assertion_content_comment('oboGo_Number2_Keto_3_DeoxygluconateAldolaseActivity',s("Catalysis","of","the","reaction",":","2-keto-3-deoxygluconate","=","D-glyceraldehyde","+","pyruvate","."),4325766). assertion_content_comment('oboGo_Number2_Keto_3_Deoxygluconate_HydrogenSymporterActivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","2-keto-3-deoxygluconate","(","out",")","+","H","+","(","out",")","=","2-keto-3-deoxygluconate","(","in",")","+","H","+","(","in",")"),4290273). assertion_content_comment('oboGo_Number2_Keto_3_DeoxygluconateTransport',s("The","directed","movement","of","2-keto-3-deoxygluconate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4351325). assertion_content_comment('oboGo_Number2_Keto_4_MethylthiobutyrateAminotransferaseActivity',s("Catalysis","of","the","reaction",":","2-keto-4-methylthiobutyrate","+","L-glutamine","=","2-oxoglutaramate","+","L-methionine","."),4325733). assertion_content_comment('oboGo_Number2KetobutyrateformateLyaseactivity',s("Catalysis","of","the","reaction",":","2-oxobutanoate","+","coenzyme","A","=","propionyl-CoA","+","formate","."),4326810). assertion_content_comment('oboGo_Number2_Ketocyclohexane_1_Carboxyl_CoAHydrolaseActivity',s("Catalysis","of","the","reaction",":","2-ketocyclohexane-1-carboxyl-CoA","+","H2O","=","pimeloyl-CoA","."),4275079). assertion_content_comment('oboGo_Number2_Mercaptobenzothiazole_Cis_67_DihydrodiolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2-mercaptobenzothiazole-cis-6",",","7-dihydrodiol","=","6",",","7-dihydroxy-2-mercaptobenzothiazole","+","2","H","+","+","2","e-","."),4350674). assertion_content_comment('oboGo_Number2Mercaptobenzothiazoledesulfuraseactivity',s("Catalysis","of","the","reaction",":","2-mercaptobenzothiazole","+","reduced","acceptor","=","benzothiazole","+","hydrogen","sulfide","+","oxidized","acceptor","."),4350911). assertion_content_comment('oboGo_Number2Mercaptobenzothiazoledioxygenaseactivity',s("Catalysis","of","the","reaction",":","2-mercaptobenzothiazole","+","O2","+","2","H","+","+","2","e-","=","2-mercaptobenzothiazole-cis-6",",","7-dihydrodiol","."),4350656). assertion_content_comment('oboGo_Number2Mercaptobenzothiazolemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","2-mercaptobenzothiazole","+","1/2","O2","=","6-hydroxy-2-mercaptobenzothiazole","."),4350629). assertion_content_comment('oboGo_Number2_Methyl_6_Phytyl_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-methyl-6-phytyl-1",",","4-benzoquinone","+","S-adenosyl-methionine","=","2",",","3-dimethyl-6-phytyl-1",",","4-benzoquinone","+","S-adenosyl-homocysteine","."),4279883). assertion_content_comment('oboGo_Number2_Methyl_6_Solanyl_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-methyl-6-solanyl-1",",","4-benzoquinone","+","S-adenosyl-methionine","=","2",",","3-dimethyl-6-solanyl-1",",","4-benzoquinone","+","S-adenosyl-homocysteine","."),4279853). assertion_content_comment('oboGo_Number2MethylacylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-methylbutanoyl-CoA","+","acceptor","=","2-methylbut-2-enoyl-CoA","+","reduced","acceptor","."),4188827). assertion_content_comment('oboGo_Number2MethylBranchedChainEnoylCoareductaseactivity',s("Catalysis","of","the","reaction",":","2-methylbutanoyl-CoA","+","NAD","(","+",")","=","2-methylbut-2-enoyl-CoA","+","H","(","+",")","+","NADH","."),4365849). assertion_content_comment('oboGo_Number2Methylbutanol_Nadpoxidoreductaseactivity',s("Catalysis","of","the","reaction",":","2-methylbutanol","+","NADP","+","=","2-methylbutanal","+","NADPH","+","H","+"),4330712). assertion_content_comment('oboGo_Number2Methylcitratedehydrataseactivity',s("Catalysis","of","the","reaction",":","(","2S",",","3S",")","-2-methylcitrate","=","cis-2-methylaconitate","+","H","(","2",")","O","."),4371195). assertion_content_comment('oboGo_Number2Methylcitratesynthaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","oxaloacetate","+","propanoyl-CoA","=","(","2R",",","3S",")","-2-methylcitrate","+","CoA","+","H","(","+",")"),4267023). assertion_content_comment('oboGo_Number2Methyleneglutaratemutaseactivity',s("Catalysis","of","the","reaction",":","2-methyleneglutarate","=","2-methylene-3-methylsuccinate","."),4371183). assertion_content_comment('oboGo_Number2Methylguanosinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2-methylguanosine","."),4181340). assertion_content_comment('oboGo_Number2_Methylhex_2_Enoyl_CoAHydrataseActivity',s("Catalysis","of","the","reaction",":","2-methylhex-2-enoyl-CoA","+","H2O","=","3-hydroxy-2-methylhexanoyl-CoA","."),4350367). assertion_content_comment('oboGo_Number2MethylhexanoylCoacAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","4-methyl-3-oxooctanoyl-CoA","+","CoA","=","acetyl-CoA","+","2-methylhexanoyl-CoA","."),4350349). assertion_content_comment('oboGo_Number2MethylhexanoylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-methylhexanoyl-CoA","=","2-methylhex-2-enoyl-CoA","+","2","H","+","+","e-","."),4350376). assertion_content_comment('oboGo_Number2Methylisocitratedehydrataseactivity',s("Catalysis","of","the","reaction",":","(","2S",",","3R",")","-3-hydroxybutane-1",",","2",",","3-tricarboxylate","=","cis-2-methylaconitate","+","H","(","2",")","O","."),4369340). assertion_content_comment('oboGo_Number2Methylnaphthalenehydroxylaseactivity',s("Catalysis","of","the","reaction",":","2-methylnaphthalene","+","NADH","+","O2","+","H","+","=","2-hydroxymethylnaphthalene","+","NAD","+","+","H2O","."),4352201). assertion_content_comment('oboGo_Number2Methylthiobenzothiazolemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","2-","(","methylthio",")","benzothiazole","+","1/2","O2","=","2-","(","methylsulfinyl",")","benzothiazole","."),4350847). assertion_content_comment('oboGo_Number2Micrometercircledna',s("A","plasmid","commonly","found","in","Saccharomyces",",","inherited","in","a","non-Mendelian","manner","and","often","present","in","100-400","copies","."),4219866). assertion_content_comment('oboGo_Number2Micrometerplasmidpartitioning',s("The","process","in","which","copies","of","the","2-micrometer","plasmid",",","found","in","fungi","such","as","Saccharomyces",",","are","distributed","to","daughter","cells","upon","cell","division","."),4310821). assertion_content_comment('oboGo_Number2Naphthaldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-naphthaldehyde","+","NAD","+","+","H2O","=","2-naphthoate","+","NADH","+","H","+"),4352064). assertion_content_comment('oboGo_Number2NaphthoatecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","2-naphthoyl-CoA","+","OH-","=","2-naphthoate","+","CoASH","."),4350775). assertion_content_comment('oboGo_Number2Nitrophenol2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","2-nitrophenol","+","2","H","(","+",")","+","2","NADPH","+","O","(","2",")","=","catechol","+","H","(","2",")","O","+","2","NADP","(","+",")","+","nitrite","."),4371002). assertion_content_comment('oboGo_Number2Nitropropanebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2-nitropropane",",","a","clear",",","colorless","liquid","with","a","mild",",","fruity","odor","."),4349913). assertion_content_comment('oboGo_Number2Nitropropanecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2-nitropropane",",","a","clear",",","colorless","liquid","with","a","mild",",","fruity","odor","."),4349940). assertion_content_comment('oboGo_Number2Nitropropanemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2-nitropropane",",","a","clear",",","colorless","liquid","with","a","mild",",","fruity","odor",".","2-nitropropane","is","used","principally","as","a","solvent","and","chemical","intermediate",".","As","a","solvent",",","it","is","used","in","inks",",","paints",",","adhesives",",","varnishes",",","polymers",",","and","synthetic","materials",".","It","is","a","feedstock","for","the","manufacture","of","2-nitro-2-methyl-1-propanol","and","2-amino-2-methyl-1-propanol","."),4272731). assertion_content_comment('oboGo_Number2_Nonaprenyl_6_Methoxy_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-nonaprenyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-methionine","=","2-nonaprenyl-3-methyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-homocysteine","."),4324945). assertion_content_comment('oboGo_Number2_Octaprenyl_3_Methyl_5_Hydroxy_6_Methoxy_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1",",","4-benzoquinol","+","S-adenosyl-L-methionine","=","ubiquinol","+","S-adenosyl-L-homocysteine","."),4324896). assertion_content_comment('oboGo_Number2_Octaprenyl_3_Methyl_6_Methoxy_14_BenzoquinolHydroxylaseActivity',s("Catalysis","of","the","reaction",":","2-octaprenyl-3-methyl-6-methoxy-1",",","4-benzoquinol","+","O2","+","H","+","=","2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1",",","4-benzoquinol","+","H2O","."),4326272). assertion_content_comment('oboGo_Number2_Octaprenyl_6_Methoxy_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-octaprenyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-methionine","=","2-octaprenyl-3-methyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-homocysteine","."),4318261). assertion_content_comment('oboGo_Number2_Octaprenyl_6_MethoxyphenolHydroxylaseActivity',s("Catalysis","of","the","reaction",":","2-octaprenyl-6-methoxyphenol","+","O2","+","4","H","+","=","2-octaprenyl-6-methoxy-1",",","4-benzoquinol","+","H2O","."),4251293). assertion_content_comment('oboGo_Number2Octaprenylphenolhydroxylaseactivity',s("Catalysis","of","the","reaction",":","2","2-octaprenylphenol","+","O2","=","2","2-octaprenyl-6-hydroxyphenol","."),4237690). assertion_content_comment('oboGo_Number2_Octoprenyl_3_Methyl_6_Methoxy_14_BenzoquinoneHydroxylaseActivity',s("Catalysis","of","the","reaction",":","2-octoprenyl-3-methyl-6-methoxy-1",",","4-benzoquinone","+","O2","=","2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1",",","4-benzoquinone","."),4251283). assertion_content_comment('oboGo_Number2_Oxo_4_Hydroxy_4_Carboxy_5_UreidoimidazolineDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","5-hydroxy-2-oxo-4-ureido-2",",","5-dihydro-1H","imidazole-5-carboxylate","+","H","+","=","S-allantoin","+","CO2","."),4183587). assertion_content_comment('oboGo_Number2OxoAcidreductaseactivity',s("Catalysis","of","the","reaction",":","a","(","2R",")","-hydroxy-carboxylate","+","acceptor","=","a","2-oxo-carboxylate","+","reduced","acceptor","."),4342014). assertion_content_comment('oboGo_Number2Oxoadipatereductaseactivity',s("Catalysis","of","the","reaction",":","2-hydroxyadipate","+","NAD","(","+",")","=","2-oxoadipate","+","H","(","+",")","+","NADH","."),4371146). assertion_content_comment('oboGo_Number2Oxoaldehydedehydrogenasenadactivity',s("Catalysis","of","the","reaction",":","a","2-oxoaldehyde","+","NAD","+","+","H2O","=","a","2-oxo","acid","+","NADH","+","H","+"),4371130). assertion_content_comment('oboGo_Number2Oxoaldehydedehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","a","2-oxoaldehyde","+","NADP","+","+","H2O","=","a","2-oxo","acid","+","NADPH","+","H","+"),4371032). assertion_content_comment('oboGo_Number2Oxobutyratebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","2-oxobutyrate",",","the","anion","of","the","organic","acid","2-oxobutyric","acid",",","which","contains","a","ketone","group","on","carbon","2","."),4348932). assertion_content_comment('oboGo_Number2Oxobutyratecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","2-oxobutyrate",",","the","anion","of","the","organic","acid","2-oxobutyric","acid",",","which","contains","a","ketone","group","on","carbon","2","."),4243681). assertion_content_comment('oboGo_Number2Oxobutyratemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","2-oxobutyrate",",","the","anion","of","the","organic","acid","2-oxobutyric","acid",",","which","contains","a","ketone","group","on","carbon","2","."),4243676). assertion_content_comment('oboGo_Number2Oxobutyratesynthaseactivity',s("Catalysis","of","the","reaction",":","2-oxobutanoate","+","CoA","+","oxidized","ferredoxin","=","propanoyl-CoA","+","CO2","+","reduced","ferredoxin","."),4277344). assertion_content_comment('oboGo_Number2_Oxo_Delta3_455_Trimethylcyclopentenylacetyl_CoA12_MonooxygenaseActivity',s("Catalysis","of","the","reaction",":","2-oxo-delta3-4",",","5",",","5-trimethylcyclopentenylacetyl-CoA","+","NADH","+","H","+","+","O2","=","NAD","+","+","H2O","+","delta2",",","5-3",",","4",",","4-trimethylpimelyl-CoA","."),4276148). assertion_content_comment('oboGo_Number2_Oxo_Delta3_455_Trimethylcyclopentenylacetyl_CoASynthetaseActivity',s("Catalysis","of","the","reaction",":","2-oxo-delta3-4",",","5",",","5-trimethylcyclopentenylacetate","+","ATP","+","CoA","=","AMP","+","diphosphate","+","2-oxo-delta3-4",",","5",",","5-trimethylcyclopentenylacetyl-CoA","."),4273731). assertion_content_comment('oboGo_Number2Oxoglutaratecarboxylaseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","ATP","+","bicarbonate","=","ADP","+","2","H","(","+",")","+","oxalosuccinate","+","phosphate","."),4361093). assertion_content_comment('oboGo_Number2Oxoglutaratedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","H","(","+",")","=","CO","(","2",")","+","succinate","semialdehyde","."),4251319). assertion_content_comment('oboGo_Number2OxoglutarateDependentdioxygenaseactivity',s("Hydroxylase",",","with","2-oxoglutarate","as","one","donor",",","and","incorporation","or","reduction","of","one","atom","each","of","oxygen","into","both","donors","."),4332488). assertion_content_comment('oboGo_Number2Oxoglutaratemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","oxoglutarate",",","the","dianion","of","2-oxoglutaric","acid",".","It","is","a","key","constituent","of","the","TCA","cycle","and","a","key","intermediate","in","amino-acid","metabolism","."),4224469). assertion_content_comment('oboGo_Number2Oxoglutaratesynthaseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","CoA","+","oxidized","ferredoxin","=","succinyl-CoA","+","CO2","+","reduced","ferredoxin","."),4371015). assertion_content_comment('oboGo_Number2OxoglutarylCoathioesteraseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutaryl-CoA","+","OH-","=","2-oxoglutarate","+","CoASH","."),4350692). assertion_content_comment('oboGo_Number2_Oxo_Hept_3_Ene_17_DioateHydrataseActivity',s("Catalysis","of","the","reaction",":","cis-2-oxohept-3-ene-1",",","7-dioate","+","H2O","=","2",",","4-dihydroxy-hept-trans-2-ene-1",",","7-dioate","."),4273594). assertion_content_comment('oboGo_Number2Oxoisovaleratedehydrogenaseacylatingactivity',s("Catalysis","of","the","reaction",":","NAD","+","+","CoA","+","2-keto-isovalerate","=","NADH","+","CO2","+","isobutyryl-CoA","."),4365999). assertion_content_comment('oboGo_Number2_Oxopent_4_EnoateHydrataseActivity',s("Catalysis","of","the","reaction",":","4-hydroxy-2-oxopentanoate","=","2-oxopent-4-enoate","+","H2O","."),4251304). assertion_content_comment('oboGo_Number2OxopropylComreductasecarboxylatingactivity',s("Catalysis","of","the","reaction",":","acetoacetate","+","coenzyme","M","+","NADP","(","+",")","=","2-oxopropyl-coenzyme","M","+","CO","(","2",")","+","NADPH","."),4277859). assertion_content_comment('oboGo_Number2Phenanthrolsulfotransferaseactivity',s("Catalysis","of","the","reaction",":","2-phenanthrol","+","X-SO3","(","-",")","=","HX","+","2-phenanthrylsulfate","."),4275186). assertion_content_comment('oboGo_Number2Phosphosulfolactatephosphataseactivity',s("Catalysis","of","the","reaction",":","(","2R",")","-O-phospho-3-sulfolactate","+","H","(","2",")","O","=","(","R",")","-3-sulfolactate","+","phosphate","."),4268625). assertion_content_comment('oboGo_Number2Phosphotransferaseactivity',s("Catalysis","of","the","transfer","of","a","phosphate","group","from","one","compound","to","the","2","'","position","of","another","."),4251083). assertion_content_comment('oboGo_Number2_Phytyl_14_NaphthoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","demethylphylloquinone","+","S-adenosyl-L-methionine","=","phylloquinone","+","S-adenosyl-L-homocysteine","+","H","+"),4191278). assertion_content_comment('oboGo_Number2_Polyprenyl_6_Methoxy_14_BenzoquinoneMethyltransferaseActivity',s("Catalysis","of","the","reaction",":","2-polyprenyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-methionine","=","2-polyprenyl-3-methyl-6-methoxy-1",",","4-benzoquinone","+","S-adenosyl-L-homocysteine","."),4253523). assertion_content_comment('oboGo_Number2_Pyrone_46_DicarboxylateLactonaseActivity',s("Catalysis","of","the","reaction",":","2-oxo-2H-pyran-4",",","6-dicarboxylate","+","H","(","2",")","O","=","4-carboxy-2-hydroxyhexa-2",",","4-dienedioate","+","H","(","+",")"),4371068). assertion_content_comment('oboGo_Number2RHydroxypropylComdehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-","(","R",")","-hydroxypropyl-coenzyme","M","+","NAD","(","+",")","=","2-oxopropyl-coenzyme","M","+","H","(","+",")","+","NADH","."),4267934). assertion_content_comment('oboGo_Number2SHydroxypropylComdehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2-","(","S",")","-hydroxypropyl-coenzyme","M","+","NAD","(","+",")","=","2-oxopropyl-coenzyme","M","+","H","(","+",")","+","NADH","."),4267922). assertion_content_comment('oboGo_Number2_Succinyl_5_Enolpyruvyl_6_Hydroxy_3_Cyclohexene_1_Carboxylic_AcidSynthaseActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","H","(","+",")","+","isochorismate","=","5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate","+","CO","(","2",")"),4173811). assertion_content_comment('oboGo_Number2_Succinyl_6_Hydroxy_24_Cyclohexadiene_1_CarboxylateSynthaseActivity_3',s("OBSOLETE",".","Catalysis","of","the","reaction",":","2-oxoglutarate","+","isochorismate","=","2-succinyl-6-hydroxy-2",",","4-cyclohexadiene-1-carboxylate","+","pyruvate","+","CO2","."),4351315). assertion_content_comment('oboGo_Number2_Succinyl_6_Hydroxy_24_Cyclohexadiene_1_CarboxylateSynthaseActivity',s("Catalysis","of","the","reaction",":","5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate","=","(","1R",",","6R",")","-2-succinyl-6-hydroxycyclohexa-2",",","4-diene-1-carboxylate","+","pyruvate","."),4173783). assertion_content_comment('oboGo_Number2Z_24_Dihydroxydec_2_EnedioateAldolaseActivity',s("Catalysis","of","the","reaction",":","(","2Z",")","-2",",","4-dihydroxydec-2-enedioate","=","pyruvate","+","7-oxoheptanoate","."),4350602). assertion_content_comment('oboGo_Number3_23_DihydroxyphenylPropionate12_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","3-","(","2",",","3-dihydroxyphenyl",")","propionate","+","O2","=","2-hydroxy-6-keto-nona-2",",","4-dienedioate","."),4278902). assertion_content_comment('oboGo_Number325Bisphosphatenucleotidaseactivity',s("Catalysis","of","the","reaction",":","adenosine","3","'",",","5","'","-bisphosphate","+","H2O","=","adenosine","5","'","-phosphate","+","phosphate","."),4253806). assertion_content_comment('oboGo_Number3355Tetrabromobisphenolareductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","3",",","3","'",",","5",",","5","'","-tetrabromobisphenol","A","+","2","H","+","+","2","e-","=","3",",","3","'",",","5-tribromobisphenol","A","+","HBr","."),4352732). assertion_content_comment('oboGo_Number335Tribromobisphenolareductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","3",",","3","'",",","5-tribromobisphenol","A","+","2","H","+","+","2","e-","=","3",",","3","'","-dibromobisphenol","A","+","HBr","."),4352859). assertion_content_comment('oboGo_Number33Dibromobisphenolareductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","3",",","3","'","-dibromobisphenol","A","+","2","H","+","+","2","e-","=","3-monobromobisphenol","A","+","HBr","."),4352850). assertion_content_comment('oboGo_Number3_3_HydroxyPhenylpropionateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","3-","(","3-hydroxy",")","phenylpropionate",",","a","hydroxylated","derivative","of","phenylpropionate","."),4243950). assertion_content_comment('oboGo_Number3_3_HydroxyphenylPropionateHydroxylaseActivity',s("Catalysis","of","the","reaction",":","3-","(","3-hydroxyphenyl",")","propionate","+","NADH","+","oxygen","+","H","+","=","3-","(","2",",","3-dihydroxyphenyl",")","propionate","+","NAD","+","+","H2O","."),4251260). assertion_content_comment('oboGo_Number3_3_HydroxyPhenylpropionateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","3-","(","3-hydroxy",")","phenylpropionate",",","a","hydroxylated","derivative","of","phenylpropionate","."),4243947). assertion_content_comment('oboGo_Number34DichloroanilinenMalonyltransferaseactivity',s("Catalysis","of","the","reaction",":","3",",","4-dichloroaniline","+","malonyl-CoA","=","N-","(","3",",","4-dichlorophenyl",")","malonamate","+","CoA","."),4365203). assertion_content_comment('oboGo_Number34Didehydroretinalbinding',s("Interacting","selectively","and","non-covalently","with","3",",","4-didehydroretinal",",","a","form","of","retinal","that","plays","a","role","in","the","visual","process","in","freshwater","fish","and","some","amphibians","analogous","to","that","of","all-trans","retinal","in","other","vertebrates",".","3",",","4-didehydro-11-cis-retinal","combines","with","an","opsin","to","form","cyanopsin","(","cone",")","or","porphyropsin","(","rod",")"),4297096). assertion_content_comment('oboGo_Number34Dihydrocoumarinhydrolaseactivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydrocoumarin","+","H2O","=","3-","(","2-hydroxyphenyl",")","propionate","."),4275039). assertion_content_comment('oboGo_Number34_Dihydroxy_2_Butanone_4_PhosphateSynthaseActivity',s("Catalysis","of","the","reaction",":","D-ribulose","5-phosphate","=","(","2S",")","-2-hydroxy-3-oxobutyl","phosphate","+","formate","+","H","(","+",")"),4251237). assertion_content_comment('oboGo_Number34_Dihydroxy_34_DihydrofluoreneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","+",")","-","(","3S",",","4R",")","-cis-3",",","4-dihydroxy-3",",","4-dihydrofluorene","=","3",",","4-dihydroxyfluorene","+","2","H","+","+","2","e-","."),4349803). assertion_content_comment('oboGo_Number34_Dihydroxy_910_Secoandrosta_13510_Triene_917_Dione45_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydroxy-9",",","10-secoandrosta-1",",","3",",","5","(","10",")","-triene-9",",","17-dione","+","O","(","2",")","=","3-hydroxy-5",",","9",",","17-trioxo-4",",","5",":","9",",","10-disecoandrosta-1","(","10",")",",","2-dien-4-oate","+","H","(","+",")"),4365138). assertion_content_comment('oboGo_Number34Dihydroxyfluorene44AlphaDioxygenaseactivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydroxyfluorene","+","O2","=","2-hydroxy-4-","(","1-oxo-1",",","3-dihydro-2H-inden-2-ylidene",")","but-2-enoic","acid","."),4278809). assertion_content_comment('oboGo_Number34Dihydroxyphenanthrenedioxygenaseactivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydroxyphenanthrene","+","O2","=","H","+","+","2-hydroxy-2","H-benzo","[","h","]","chromene-2-carboxylate","."),4278791). assertion_content_comment('oboGo_Number34Dihydroxyphenylacetate23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydroxyphenylacetate","+","O","(","2",")","=","5-formyl-2-hydroxyhepta-2",",","4-dienedioate","+","H","(","+",")"),4251270). assertion_content_comment('oboGo_Number34Dihydroxyphthalatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydroxyphthalate","+","H","(","+",")","=","3",",","4-dihydroxybenzoate","+","CO","(","2",")"),4371090). assertion_content_comment('oboGo_Number35CyclicAmpphosphodiesteraseactivity',s("Catalysis","of","the","reaction",":","adenosine","3","'",",","5","'","-cyclic","phosphate","+","H2O","=","adenosine","5","'","-phosphate","."),4212072). assertion_content_comment('oboGo_Number35Cyclicdiguanylicacidmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","3","'",",","5","'","-cyclic","diguanylic","acid",",","a","cyclic","purine","dinucleotide","in","which","the","base","groups","are","guanine","."),4191884). assertion_content_comment('oboGo_Number35CyclicGmpphosphodiesteraseactivity',s("Catalysis","of","the","reaction",":","guanosine","3","'",",","5","'","-cyclic","phosphate","+","H2O","=","guanosine","5","'","-phosphate","."),4371048). assertion_content_comment('oboGo_Number35CyclicNucleotidephosphodiesteraseactivity',s("Catalysis","of","the","reaction",":","nucleoside","3","'",",","5","'","-cyclic","phosphate","+","H2O","=","nucleoside","5","'","-phosphate","."),4211488). assertion_content_comment('oboGo_Number35_Dibromo_4_HydroxybenzoateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","3",",","5-dibromo-4-hydroxybenzoate","+","H","+","=","CO2","+","2",",","6-dibromophenol","."),4274207). assertion_content_comment('oboGo_Number35Dichlorocatechol12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","3",",","5-dichlorocatechol","+","O2","=","2","H","+","2",",","4-dichloro-cis",",","cis-muconate","."),4278701). assertion_content_comment('oboGo_Number35Dichlorophenylcarboximidehydrolaseactivity',s("Catalysis","of","the","reaction",":","3",",","5-dichlorophenylcarboximide","+","OH-","=","(","3",",","5-dichlorophenylurea",")","acetate","."),4274723). assertion_content_comment('oboGo_Number35Dichlorophenylureaacetateamidohydrolaseactivity',s("Catalysis","of","the","reaction",":","(","3",",","5-dichlorophenylurea",")","acetate","+","OH-","=","3",",","5-dichloroaniline","+","N-carboxyglycine","."),4274940). assertion_content_comment('oboGo_Number3_5DNAHelicaseActivity',s("Catalysis","of","the","unwinding","of","the","DNA","helix","in","the","direction","3","'","to","5","'"),4317502). assertion_content_comment('oboGo_Number3_5DNARNAHelicaseActivity',s("Catalysis","of","the","unwinding","of","a","DNA/RNA","duplex","in","the","direction","3","'","to","5","'"),4341188). assertion_content_comment('oboGo_Number3_5_ExodeoxyribonucleaseActivity',s("Catalysis","of","the","sequential","cleavage","of","mononucleotides","from","a","free","3","'","terminus","of","a","DNA","molecule","."),4255417). assertion_content_comment('oboGo_Number3_5ExonucleaseActivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","nucleic","acids","by","removing","nucleotide","residues","from","the","3","'","end","."),4204855). assertion_content_comment('oboGo_Number3_5_ExoribonucleaseActivity',s("Catalysis","of","the","sequential","cleavage","of","mononucleotides","from","a","free","3","'","terminus","of","an","RNA","molecule","."),4204882). assertion_content_comment('oboGo_Number3_5RNAHelicaseActivity',s("Catalysis","of","the","unwinding","of","an","RNA","helix","in","the","direction","3","'","to","5","'"),4357157). assertion_content_comment('oboGo_Number35Xylenolmethylhydroxylaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxytoluene","+","NADH","+","O2","=","NAD","+","+","OH-","+","3-hydroxybenzyl","alcohol","."),4275962). assertion_content_comment('oboGo_Number37Dimethylquercitin4OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","3","'",",","4","'",",","5-trihydroxy-3",",","7-dimethoxyflavone","+","S-adenosyl-L-methionine","(","1","+",")","=","3","'",",","5-dihydroxy-3",",","4","'",",","7-trimethoxyflavone","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4308643). assertion_content_comment('oboGo_Number38Divinylprotochlorophyllidea8Vinylreductaseactivity',s("Catalysis","of","the","reaction",":","divinyl","protochlorophyllide","a","+","NADPH","+","H","+","=","monovinyl","protochlorophyllide","a","+","NADP","+"),4279833). assertion_content_comment('oboGo_Number39Dihydroxypterocarpan6aMonooxygenaseactivity',s("Catalysis","of","the","reaction",":","(","6aR",",","11aR",")","-3",",","9-dihydroxypterocarpan","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","(","6aS",",","11aS",")","-3",",","6a",",","9-trihydroxypterocarpan","+","H","(","2",")","O","+","NADP","(","+",")","(","6aS",",","11aS",")","-3",",","6a",",","9-trihydroxypterocarpan","is","also","known","as","(","-",")","-glycinol","."),4365043). assertion_content_comment('oboGo_Number3AciNitropropanoateoxidaseactivity',s("Catalysis","of","the","reaction",":","3-aci-nitropropanoate","+","H","(","2",")","O","+","O","(","2",")","=","3-oxopropanoate","+","H","(","2",")","O","(","2",")","+","nitrite","."),4371078). assertion_content_comment('oboGo_Number3alpha7alpha12alpha_Trihydroxy_5beta_Cholest_24_Enoyl_CoAHydrataseActivity',s("Catalysis","of","the","reaction",":","(","24R",",","25R",")","-3alpha",",","7alpha",",","12alpha",",","24-tetrahydroxy-5beta-cholestanoyl-CoA","=","(","24E",")","-3alpha",",","7alpha",",","12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA","+","H2O","."),4345298). assertion_content_comment('oboGo_Number3alpha7alpha12alpha_Trihydroxy_5beta_Cholestanoyl_CoA24_HydroxylaseActivity',s("Catalysis","of","the","reaction",":","(","25R",")","-3alpha",",","7alpha",",","12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA","+","H2O","+","acceptor","=","(","24R",",","25R",")","-3alpha",",","7alpha",",","12alpha",",","24-tetrahydroxy-5beta-cholestan-26-oyl-CoA","+","reduced","acceptor","."),4342321). assertion_content_comment('oboGo_Number3_Alpha7_Alpha12_Alpha_Trihydroxycholestan_26_Al26_OxidoreductaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","NAD","+","+","3-alpha",",","7-alpha",",","12-alpha-trihydroxy-5-beta-cholestan-26-al","=","NADH","+","3-alpha",",","7-alpha",",","12-alpha-trihydroxy-5-beta-cholestanate","."),4366021). assertion_content_comment('oboGo_Number3alpha7alpha12beta_Trihydroxy_5beta_CholanateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","3alpha",",","7alpha",",","12beta-trihydroxy-5beta-cholanate","+","NADP","(","+",")","=","3alpha",",","7alpha-dihydroxy-12-oxo-5beta-cholanate","+","H","(","+",")","+","NADPH","."),4371486). assertion_content_comment('oboGo_Number3_Alpha7_Alpha_Dihydroxy_5_Beta_Cholestanate_CoALigaseActivity',s("Catalysis","of","the","reaction",":","CoA","+","3-alpha",",","7-alpha-dihydroxy-5-beta-cholestanate","+","ATP","=","3-alpha",",","7-alpha-dihydroxy-5-beta-cholestanoyl-CoA","+","diphosphate","+","AMP","."),4369642). assertion_content_comment('oboGo_Number3_Alpha_Hydroxy_5_Beta_Androstane_17_One3_Alpha_DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","+","+","3-alpha-hydroxy-5-beta-androstane-17-one","=","NADH","+","H","+","+","5-beta-androstane-3",",","17-dione","."),4364442). assertion_content_comment('oboGo_Number3AlphaHydroxycholanatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","lithocholate","+","NAD","(","+",")","=","3-oxo-5beta-cholanate","+","H","(","+",")","+","NADH","."),4364191). assertion_content_comment('oboGo_Number3AlphaHydroxyglycyrrhetinatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3alpha-hydroxyglycyrrhetinate","+","NADP","(","+",")","=","3-oxoglycyrrhetinate","+","H","(","+",")","+","NADPH","."),4364338). assertion_content_comment('oboGo_Number3AminobutyrylCoaammoniaLyaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-aminobutanoyl-CoA","=","crotonoyl-CoA","+","NH","(","4",")","(","+",")"),4369376). assertion_content_comment('oboGo_Number3_AminopropylL_Aspartyl_1_AminoPhosphoryl_5_AdenosineBiosyntheticProcessFromAsparagine',s("The","modification","of","asparagine","to","(","3-aminopropyl",")","(","L-aspartyl-1-amino",")","phosphoryl-5","'","-adenosine","as","found","in","microcin","C7","produced","from","the","mccA","gene","in","E",".","coli","plasmid","pMccC7","."),4359035). assertion_content_comment('oboGo_Number3beta_Hydroxy_5alpha_SteroidDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","3beta-hydroxy-5alpha-pregnane-20-one","+","NADP","(","+",")","=","5alpha-pregnane-3",",","20-dione","+","H","(","+",")","+","NADPH","."),4341791). assertion_content_comment('oboGo_Number3beta_Hydroxy_5beta_SteroidDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","3beta-hydroxy-5beta-pregnane-20-one","+","NADP","(","+",")","=","5beta-pregnan-3",",","20-dione","+","H","(","+",")","+","NADPH","."),4341844). assertion_content_comment('oboGo_Number3BetaHydroxyDelta5Steroiddehydrogenaseactivity',s("Catalysis","of","the","reaction",":","a","3-beta-hydroxy-delta","(","5",")","-steroid","+","NAD","+","=","a","3-oxo-delta","(","5",")","-steroid","+","NADH","+","H","+"),4188841). assertion_content_comment('oboGo_Number3CarboxyCiscisMuconatecycloisomeraseactivity',s("Catalysis","of","the","reaction",":","2-","(","carboxymethyl",")","-5-oxo-2",",","5-dihydro-2-furoate","=","3-carboxy-cis",",","cis-muconate","+","H","(","+",")"),4369699). assertion_content_comment('oboGo_Number3Carboxyethylcatechol23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","O2","+","3-","(","2",",","3-dihydroxyphenyl",")","propanoate","=","2-hydroxy-6-oxonona-2",",","4-diene-1",",","9-dioate","."),4365056). assertion_content_comment('oboGo_Number3Carboxymuconatecycloisomerasetypeiiactivity',s("Catalysis","of","the","reaction",":","3-sulfomuconate","=","4-sulfolactone","."),4273821). assertion_content_comment('oboGo_Number3Chloroacrylicacidmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","3-chloroacrylic","acid",",","ClHC","=","CHCOOH",",","a","chlorinated","derivative","of","acrylic","acid","."),4273388). assertion_content_comment('oboGo_Number3Chloroallylaldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3-chloroallyl","aldehyde","+","H2O","=","2","H","+","+","2","e-","+","3-chloroacrylic","acid","."),4213271). assertion_content_comment('oboGo_Number3ChloroDAlaninedehydrochlorinaseactivity',s("Catalysis","of","the","reaction",":","3-chloro-D-alanine","+","H2O","=","pyruvate","+","chloride","+","NH3","."),4237475). assertion_content_comment('oboGo_Number3Cyanoalaninehydrataseactivity',s("Catalysis","of","the","reaction",":","L-asparagine","=","3-cyano-L-alanine","+","H","(","2",")","O","+","H","(","+",")"),4371115). assertion_content_comment('oboGo_Number3_Deamino_3_OxonicotianamineReductaseActivity',s("Catalysis","of","the","reaction",":","2","'","-deoxymugineic","acid","+","NAD","(","P",")","+","=","3","'","'","-deamino-3","'","'","-oxonicotianamine","+","NAD","(","P",")","H","+","H","+"),4341801). assertion_content_comment('oboGo_Number3DehydroLGulonate2Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3-dehydro-L-gulonate","+","NAD","(","P",")","+","=","(","4R",",","5S",")","-4",",","5",",","6-trihydroxy-2",",","3-dioxohexanoate","+","NAD","(","P",")","H","+","H","+"),4371102). assertion_content_comment('oboGo_Number3_Dehydro_L_Gulonate_6_PhosphateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","3-dehydro-L-gulonate","6-phosphate","+","H","(","+",")","=","L-xylulose","5-phosphate","+","CO","(","2",")"),4344908). assertion_content_comment('oboGo_Number3Dehydroquinatedehydrataseactivity',s("Catalysis","of","the","reaction",":","3-dehydroquinate","=","3-dehydroshikimate","+","H","(","2",")","O","."),4188866). assertion_content_comment('oboGo_Number3Dehydroquinatesynthaseactivity',s("Catalysis","of","the","reaction",":","7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","=","3-dehydroquinate","+","phosphate","."),4188886). assertion_content_comment('oboGo_Number3Dehydroshikimatedehydrataseactivity',s("Catalysis","of","the","reaction",":","3-dehydroshikimate","=","3",",","4-dihydroxybenzoate","+","H2O",".","3",",","4-dihydroxybenzoate","is","also","known","as","protocatechuate","."),4358797). assertion_content_comment('oboGo_Number3Dehydrosphinganinereductaseactivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","sphinganine","=","3-dehydrosphinganine","+","H","(","+",")","+","NADPH","."),4370984). assertion_content_comment('oboGo_Number3DemethylstaurosporineoMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","3","'","-demethylstaurosporine","+","S-adenosyl-L-methionine","=","S-adenosyl-L-homocysteine","+","H","(","+",")","+","staurosporine","."),4309088). assertion_content_comment('oboGo_Number3_Demethylubiquinone_93_O_MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","3-demethylubiquinone-9","=","S-adenosyl-L-homocysteine","+","ubiquinone-9","."),4251335). assertion_content_comment('oboGo_Number3_Deoxy_2_OctulosonidaseActivity',s("Catalysis","of","the","endohydrolysis","of","the","beta-ketopyranosidic","linkages","of","3-deoxy-D-manno-2-octulosonate","in","capsular","polysaccharides","."),4344819). assertion_content_comment('oboGo_Number3_Deoxy_7_PhosphoheptulonateSynthaseActivity',s("Catalysis","of","the","reaction",":","D-erythrose","4-phosphate","+","H","(","2",")","O","+","phosphoenolpyruvate","=","7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","+","phosphate","."),4189008). assertion_content_comment('oboGo_Number3_Deoxy_8_PhosphooctulonateSynthaseActivity',s("Catalysis","of","the","reaction",":","D-arabinose","5-phosphate","+","H","(","2",")","O","+","phosphoenolpyruvate","=","8-phospho-3-deoxy-D-manno-oct-2-ulosonate","+","2","H","(","+",")","+","phosphate","."),4250891). assertion_content_comment('oboGo_Number3DeoxyDMannoOctulosonatealdolaseactivity',s("Catalysis","of","the","reaction",":","3-deoxy-D-manno-octulosonate","=","D-arabinose","+","pyruvate","."),4370099). assertion_content_comment('oboGo_Number3_Deoxy_Manno_Octulosonate_8_PhosphataseActivity',s("Catalysis","of","the","reaction",":","8-phospho-3-deoxy-D-manno-oct-2-ulosonate","+","H","(","2",")","O","=","3-deoxy-D-manno-octulosonate","+","phosphate","."),4237394). assertion_content_comment('oboGo_Number3DeoxyMannoOctulosonatecytidylyltransferaseactivity',s("Catalysis","of","the","reaction",":","CTP","+","3-deoxy-D-manno-octulosonate","=","diphosphate","+","CMP-3-deoxy-D-manno-octulosonate","."),4251117). assertion_content_comment('oboGo_Number3Deoxyoctulosonaseactivity',s("Catalysis","of","the","reaction",":","3-deoxyoctulosonyl-lipopolysaccharide","+","H2O","=","3-deoxyoctulosonic","acid","+","lipopolysaccharide","."),4268602). assertion_content_comment('oboGo_Number3E_48_Dimethyl_137_NonatrieneSynthaseActivity',s("Catalysis","of","the","reaction",":","(","E",")","-nerolidol","+","NADPH","+","O2","=","DMNT","+","NADP","+","+","2H2O",".","It","is","unknown","whether","this","reaction","proceeds","by","the","direct","release","of","the","4-carbon","compound","but-1-en-3-one",",","or","whether","the","substrate","is","first","degraded","to","C11-geranylacetone","and","then","cleaved","to","produce","DMNT","and","acetone","."),4073702). assertion_content_comment('oboGo_Number3Ethylmalatesynthaseactivity',s("Catalysis","of","the","reaction",":","butanoyl-CoA","+","glyoxylate","+","H","(","2",")","O","=","3-ethylmalate","+","CoA","+","H","(","+",")"),4267010). assertion_content_comment('oboGo_Number3Fe_4S4Fe_4SElectronTransferCarrier',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259429). assertion_content_comment('oboGo_Number3Flapendonucleaseactivity',s("Catalysis","of","the","cleavage","of","a","3","'","flap","structure","in","DNA",",","but","not","other","DNA","structures",";","processes","the","3","'","ends","of","Okazaki","fragments","in","lagging","strand","DNA","synthesis","."),4384921). assertion_content_comment('oboGo_Number3FlapStructureddnabinding',s("Interacting","selectively","and","non-covalently","with","a","3","'","-flap","structure","in","DNA",".","A","DNA","flap","structure","is","one","in","which","a","single-stranded","3","'","-end","of","DNA","or","RNA","protrudes","from","a","double-stranded","DNA","molecule","."),4173201). assertion_content_comment('oboGo_Number3Formiminopyruvatehydrolaseactivity',s("Catalysis","of","the","reaction",":","3-formiminopyruvate","+","H2O","=","3-formylpyruvate","+","HN3","."),4351205). assertion_content_comment('oboGo_Number3Formylsalicylateoxidaseactivity',s("Catalysis","of","the","reaction",":","3-formylsalicylic","acid","+","O2","+","H2O","=","2-hydroxyisophthalic","acid","+","hydrogen","peroxide","."),4352073). assertion_content_comment('oboGo_Number3GalactosylNAcetylglucosaminide4AlphaLFucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","GDP-L-fucose","+","beta-D-galactosyl-","(","1",",","3",")","-N-acetyl-D-glucosaminyl-R","=","GDP","+","beta-D-galactosyl-","(","1",",","3",")","-","[","alpha-L-fucosyl-","(","1",",","4",")","]","-N-acetyl-D-glucosaminyl-R","."),4269476). assertion_content_comment('oboGo_Number3Hsahydroxylaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxy-9",",","10-secoandrosta-1",",","3",",","5","(","10",")","-triene-9",",","17-dione","+","NADPH","+","H","+","+","O2","=","3",",","4-dihydroxy-9",",","10-secoandrosta-1",",","3",",","5","(","10",")","-triene-9",",","17-dione","+","NADP","+","+","H2O","."),4350430). assertion_content_comment('oboGo_Number3_Hydroxy_26_Dimethyl_5_Methylene_Heptanoyl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxy-2",",","6-dimethyl-5-methylene-heptanoyl-CoA","+","NAD","+","=","2",",","6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA","+","NADH","+","+","H","+"),4348777). assertion_content_comment('oboGo_Number3_Hydroxy_2_Methylbutyryl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","+","+","2-methyl-3-hydroxybutyryl-CoA","=","NADH","+","H","+","+","2-methylaceto-acetyl-CoA","."),4364064). assertion_content_comment('oboGo_Number3_Hydroxy_2_Methylhexanoyl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxy-2-methylhexanoyl-CoA","=","2-methyl-3-oxohexanoyl-CoA","+","2","H","+","+","2","e-","."),4350421). assertion_content_comment('oboGo_Number3_Hydroxy_2_Methylpyridine_45_Dicarboxylate4_DecarboxylaseActivity',s("Catalysis","of","the","reaction",":","5-hydroxy-6-methylpyridine-3",",","4-dicarboxylate","+","H","(","+",")","=","5-hydroxy-6-methylpyridine-3-carboxylate","+","CO","(","2",")"),4370293). assertion_content_comment('oboGo_Number3_Hydroxy_2_MethylpyridinecarboxylateDioxygenaseActivity',s("Catalysis","of","the","reaction",":","O2","+","NAD","(","P",")","H","+","H","+","+","3-hydroxy-2-methylpyridine-5-carboxylate","=","NAD","(","P",")","+","+","2-","(","acetamidomethylene",")","succinate","."),4364945). assertion_content_comment('oboGo_Number3_Hydroxy_2_Methylquinolin_4_One24_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxy-2-methylquinolin-4","(","1H",")","-one","+","H","(","+",")","+","O","(","2",")","=","N-acetylanthranilate","+","CO","."),4268073). assertion_content_comment('oboGo_Number3_Hydroxy_2_Naphthoate23_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxy-2-naphthoate","+","O2","=","(","3E",")","-3-","[","(","6Z",")","-6-","(","carboxymethylene",")","cyclohexa-2",",","4-dien-1-ylidene","]","-2-oxopropanate","."),4349040). assertion_content_comment('oboGo_Number3_Hydroxy_3_Isohexenylglutaryl_CoALyaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxy-3-","(","4-methylpent-3-en-1-yl",")","glutaryl-CoA","+","4","H","(","+",")","=","7-methyl-3-oxooct-6-enoyl-CoA","+","acetate","."),4370140). assertion_content_comment('oboGo_Number3_Hydroxy_4_Methyloctanoyl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","3-hydroxy-4-methyloctanoyl-CoA","=","4-methyl-3-oxooctanoyl-CoA","+","2","H","+","+","2","e-","."),4352425). assertion_content_comment('oboGo_Number3_Hydroxy_4_Oxoquinoline24_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","O2","+","3-hydroxy-1H-quinolin-4-one","=","carbon","monoxide","+","N-formylanthranilate","."),4365094). assertion_content_comment('oboGo_Number3HydroxyacylAcylCarrierProteindehydrataseactivity',s("Catalysis","of","the","reaction",":","a","(","3R",")","-3-hydroxyacyl-","[","acyl-carrier","protein","]","=","H2O","+","a","trans-delta2-enoyl-acyl-","[","acyl-carrier","protein","]"),4208822). assertion_content_comment('oboGo_Number3HydroxyacylCoadehydrataseactivity',s("Catalysis","of","the","reaction",":","alkene-CoA","+","H2O","=","alcohol-CoA",".","Substrates","are","crotonoyl-CoA","(","producing","3-hydroxyacyl-CoA",")","and","2",",","3-didehydro-pimeloyl-CoA","(","producing","3-hydroxypimeloyl-CoA",")"),4273922). assertion_content_comment('oboGo_Number3HydroxyacylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-hydroxyacyl-CoA","+","NAD","+","=","3-oxoacyl-CoA","+","NADH","+","H","+"),4189404). assertion_content_comment('oboGo_Number3Hydroxyaminophenolmutaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxyaminophenol","=","aminohydroquinone","."),4361031). assertion_content_comment('oboGo_Number3Hydroxyanthranilate34Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxyanthranilate","+","O","(","2",")","=","cis",",","cis-2-amino-3-","(","3-oxoprop-1-enyl",")","but-2-enedioate","+","H","(","+",")"),4363072). assertion_content_comment('oboGo_Number3Hydroxyanthranilate4CMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxyanthranilate","+","S-adenosyl-L-methionine","=","3-hydroxy-4-methylanthranilate","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4308484). assertion_content_comment('oboGo_Number3Hydroxyanthranilateoxidaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxyanthranilate","+","O","(","2",")","=","6-imino-5-oxocyclohexa-1",",","3-dienecarboxylate","+","H","(","2",")","O","(","2",")"),4370973). assertion_content_comment('oboGo_Number3Hydroxyaspartatealdolaseactivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-hydroxy-L-aspartate","=","glycine","+","glyoxylate","."),4370959). assertion_content_comment('oboGo_Number3Hydroxybenzoate2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxybenzoate","+","AH","(","2",")","+","O","(","2",")","=","2",",","3-dihydroxybenzoate","+","A","+","H","(","2",")","O","."),4370909). assertion_content_comment('oboGo_Number3Hydroxybenzoate4Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxybenzoate","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","3",",","4-dihydroxybenzoate","+","H","(","2",")","O","+","NADP","(","+",")"),4276567). assertion_content_comment('oboGo_Number3Hydroxybenzoate6Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxybenzoate","+","H","(","+",")","+","NADH","+","O","(","2",")","=","2",",","5-dihydroxybenzoate","+","H","(","2",")","O","+","NAD","(","+",")"),4276578). assertion_content_comment('oboGo_Number3HydroxybenzylAlcoholdehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxybenzyl","alcohol","+","NADP","(","+",")","=","3-hydroxybenzaldehyde","+","H","(","+",")","+","NADPH","."),4364277). assertion_content_comment('oboGo_Number3Hydroxybenzylalcoholmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","3-hydroxybenzyl","alcohol",",","an","aromatic","compound","which","is","an","intermediate","in","several","metabolic","pathways",",","including","the","biosynthesis","of","patulin",",","a","toxin","and","antiviral","agent","produced","by","some","moulds","such","as","Penicillium","patulinum","."),4272076). assertion_content_comment('oboGo_Number3Hydroxybutyratedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-3-hydroxybutanoate","+","NAD","(","+",")","=","acetoacetate","+","H","(","+",")","+","NADH","."),4189392). assertion_content_comment('oboGo_Number3HydroxybutyrylCoadehydrataseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-3-hydroxybutanoyl-CoA","=","crotonoyl-CoA","+","H","(","2",")","O","."),4189376). assertion_content_comment('oboGo_Number3HydroxybutyrylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-hydroxybutanoyl-CoA","+","NADP","+","=","3-acetoacetyl-CoA","+","NADPH","+","H","+"),4251138). assertion_content_comment('oboGo_Number3HydroxybutyrylCoaepimeraseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-hydroxybutanoyl-CoA","=","(","R",")","-3-hydroxybutanoyl-CoA","."),4251224). assertion_content_comment('oboGo_Number3HydroxybutyrylCoathiolaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxy-5-oxohexanoyl-CoA","+","CoASH","=","3-hydroxybutyryl-CoA","+","acetyl-CoA","."),4275255). assertion_content_comment('oboGo_Number3Hydroxycyclohexanonedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxycyclohexanone","+","A","=","AH","(","2",")","+","cyclohexane-1",",","3-dione","."),4370898). assertion_content_comment('oboGo_Number3HydroxydecanoylAcylCarrierProteindehydrataseactivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-hydroxydecanoyl-","[","acyl-carrier","protein","]","=","2",",","3-decenoyl-","[","acyl-carrier","protein","]","or","3",",","4-decenoyl-","[","acyl-carrier","protein","]","+","H2O","."),4251199). assertion_content_comment('oboGo_Number3Hydroxyisobutyratedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxy-2-methylpropanoate","+","NAD","+","=","2-methyl-3-oxopropanoate","+","NADH","+","H","+"),4253822). assertion_content_comment('oboGo_Number3HydroxyisobutyrylCoahydrolaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxy-2-methylpropanoyl-CoA","+","H2O","=","CoA","+","3-hydroxy-2-methylpropanoate","."),4189347). assertion_content_comment('oboGo_Number3Hydroxymenthonedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","5R",")","-3-hydroxymenthone","+","NAD","+","=","mentha-1",",","3-dione","+","NADH","+","H","+"),4350721). assertion_content_comment('oboGo_Number3Hydroxymethylcephemcarbamoyltransferaseactivity',s("Catalysis","of","the","reaction",":","a","3-hydroxymethylceph-3-em-4-carboxylate","+","carbamoyl-phosphate","=","phosphate","+","a","3-carbamoyloxymethylcephem","."),4365362). assertion_content_comment('oboGo_Number3HydroxyNMethylSCoclaurine4OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","3","'","-hydroxy-N-methyl-","(","S",")","-coclaurine","=","S-adenosyl-L-homocysteine","+","(","S",")","-reticuline","."),4309221). assertion_content_comment('oboGo_Number3HydroxyoctanoylAcylCarrierProteindehydrataseactivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-hydroxyoctanoyl-","[","acyl-carrier","protein","]","=","H2O","+","2-octenoyl-","[","acyl-carrier","protein","]"),4369423). assertion_content_comment('oboGo_Number3HydroxypalmitoylAcylCarrierProteindehydrataseactivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-hydroxypalmitoyl-","[","acyl-carrier","protein","]","=","2-hexadecenoyl-","[","acyl-carrier","protein","]","+","H2O","."),4208826). assertion_content_comment('oboGo_Number3Hydroxyphenylacetate6Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","O2","+","NAD","(","P",")","H","+","3-hydroxyphenylacetate","=","H2O","+","NAD","(","P",")","+","+","homogentisate","."),4364599). assertion_content_comment('oboGo_Number3Hydroxyphenylacetatebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","3-hydroxyphenylacetate",",","1",",","3-benzenediol","monoacetate",",","also","known","as","resorcinol","monoacetate","."),4354050). assertion_content_comment('oboGo_Number3Hydroxyphenylacetatecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","3-hydroxyphenylacetate",",","1",",","3-benzenediol","monoacetate",",","also","known","as","resorcinol","monoacetate","."),4243833). assertion_content_comment('oboGo_Number3Hydroxyphenylacetatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","3-hydroxyphenylacetate",",","1",",","3-benzenediol","monoacetate",",","also","known","as","resorcinol","monoacetate","."),4243697). assertion_content_comment('oboGo_Number3Hydroxyphenylpropanoatetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","3-hydroxyphenyl","propanoate","from","one","side","of","the","membrane","to","the","other","."),4293303). assertion_content_comment('oboGo_Number3Hydroxyphenylpropanoatetransport',s("The","directed","movement","of","3-hydroxyphenyl","propanoate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4290876). assertion_content_comment('oboGo_Number3Hydroxyphenylpropionate_Hydrogenionsymporteractivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","3-hydroxyphenyl","propionate","(","out",")","+","H","+","(","out",")","=","3-hydroxyphenyl","propionate","(","in",")","+","H","+","(","in",")"),4293306). assertion_content_comment('oboGo_Number3Hydroxyphenylpropionicacidtransporteractivity',s("Enables","the","directed","movement","of","3-hydroxyphenylpropionic","acid","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4315819). assertion_content_comment('oboGo_Number3Hydroxyphenylpropionicacidtransport',s("The","directed","movement","of","3-hydroxyphenylpropionic","acid","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4315787). assertion_content_comment('oboGo_Number3HydroxypimeloylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxypimelyl-CoA","+","NAD","(","+",")","=","3-oxopimelyl-CoA","+","H","(","+",")","+","NADH","."),4277435). assertion_content_comment('oboGo_Number3Hydroxypropionatedehydrogenasenadactivity',s("Catalysis","of","the","reaction",":","3-hydroxypropanoate","+","NAD","(","+",")","=","3-oxopropanoate","+","H","(","+",")","+","NADH","."),4370888). assertion_content_comment('oboGo_Number3Hydroxypropionatedehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","3-hydroxypropionate","+","NADP","+","=","malonate","semialdehyde","+","NADPH","+","H","+"),4378791). assertion_content_comment('oboGo_Number3HydroxypropionylCoadehydrataseactivity',s("Catalysis","of","the","reaction",":","3-hydroxypropionyl-CoA","=","acrylyl-CoA","+","H2O","."),4328139). assertion_content_comment('oboGo_Number3HydroxypropionylCoasynthetaseactivity',s("Catalysis","of","the","reaction",":","3-hydroxypropionate","+","ATP","+","CoA","=","3-hydroxypropionyl-CoA","+","AMP","+","diphosphate","."),4328106). assertion_content_comment('oboGo_Number3_Imidazol_5_YlLactateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-","(","imidazol-5-yl",")","lactate","+","NADP","+","=","3-","(","imidazol-5-yl",")","pyruvate","+","NADPH","+","H","+"),4237611). assertion_content_comment('oboGo_Number3_Isopropenyl_6_Oxoheptanoyl_CoASynthetaseActivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-isopropenyl-6-oxoheptanoate","+","CoA-SH","+","ATP","=","H2O","+","ADP/AMP","+","mono/diphosphate","+","(","3R",")","-3-isopropenyl-6-oxoheptanoyl-CoA","."),4273761). assertion_content_comment('oboGo_Number3_Isopropylbut_3_Enoyl_CoAThioesteraseActivity',s("Catalysis","of","the","reaction",":","3-isopropylbut-3-enoyl-CoA","+","H2O","=","3-isopropylbut-3-enoic","acid","+","CoASH","."),4348796). assertion_content_comment('oboGo_Number3Isopropylmalatedehydrataseactivity',s("Catalysis","of","the","reaction",":","3-isopropylmalate","=","2-isopropylmaleate","+","H2O","."),4189360). assertion_content_comment('oboGo_Number3Isopropylmalatedehydratasecomplex',s("A","heterodimeric","enzyme","complex","composed","of","subunits","leuC","and","leuD",".","Catalyzes","the","isomerization","between","2-isopropylmalate","and","3-isopropylmalate",",","via","the","formation","of","2-isopropylmaleate","."),4259924). assertion_content_comment('oboGo_Number3Isopropylmalatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3-carboxy-2-hydroxy-4-methylpentanoate","+","NAD","+","=","3-carboxy-4-methyl-2-oxopentanoate","+","NADH","+","H","+"),4189285). assertion_content_comment('oboGo_Number3_Keto_5_AminohexanoateCleavageActivity',s("Catalysis","of","the","reaction",":","3-keto-5-aminohexanoate","+","acetyl-CoA","=","L-3-aminobutyryl-CoA","+","acetoacetate","."),4326249). assertion_content_comment('oboGo_Number3KetoglucoseReductaseactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","3-dehydro-alpha-D-glucose","=","NADPH","+","alpha-D-glucose","."),4384911). assertion_content_comment('oboGo_Number3KetopimelylCoathiolaseactivity',s("Catalysis","of","the","reaction",":","3-ketopimeloyl-CoA","+","CoA","=","glutaryl-CoA","+","acetyl-CoA","."),4275264). assertion_content_comment('oboGo_Number3KetoSphinganinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","3-keto-sphinganine",",","a","derivative","of","sphinganine","with","a","ketone","group","at","C3",".","It","is","an","intermediate","in","the","synthesis","of","sphingosine","."),4230668). assertion_content_comment('oboGo_Number3Ketosterolreductaseactivity',s("Catalysis","of","the","reaction",":","a","3-beta-hydroxyl","sterol","+","NADP","+","=","a","3-keto","sterol","+","NADPH","+","H","+"),4346378). assertion_content_comment('oboGo_Number3KetovalidoxylaminecNLyaseactivity',s("Catalysis","of","the","reaction",":","4-nitrophenyl-3-ketovalidamine","=","4-nitroaniline","+","5-D-","(","5/6",")","-5-C-","(","hydroxymethyl",")","-2",",","6-dihydroxycyclohex-2-en-1-one","+","H","(","+",")"),4370875). assertion_content_comment('oboGo_Number3Mercaptopyruvatesulfurtransferaseactivity',s("Catalysis","of","the","reaction",":","3-mercaptopyruvate","+","cyanide","=","pyruvate","+","thiocyanate","."),4301457). assertion_content_comment('oboGo_Number3_Methyl_2_Oxo_12_Dihydroquinoline6_MonooxygenaseActivity',s("Catalysis","of","the","reaction",":","3-methyl-2-oxo-1",",","2-dihydroquinoline","+","O2","+","2","H","+","+","2","e-","=","H2O","+","6-hydroxy-3-methyl-2-oxo-1",",","2-dihydroquinoline","."),4276240). assertion_content_comment('oboGo_Number3_Methyl_2_OxobutanoateDehydrogenase2_Methylpropanoyl_TransferringActivity',s("Catalysis","of","the","reaction",":","3-methyl-2-oxobutanoate","+","lipoamide","=","S-","(","2-methylpropanoyl",")","dihydrolipoamide","+","CO2","."),4189314). assertion_content_comment('oboGo_Number3_Methyl_2_OxobutanoateDehydrogenaseAcetyl_TransferringKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","3-methyl-2-oxobutanoate","dehydrogenase","(","acetyl-transferring",")","=","ADP","+","3-methyl-2-oxobutanoate","dehydrogenase","(","acetyl-transferring",")","phosphate","."),4368965). assertion_content_comment('oboGo_Number3_Methyl_2_OxobutanoateDehydrogenaseFerredoxinActivity',s("Catalysis","of","the","reaction",":","3-methyl-2-oxobutanoate","+","CoA","+","oxidized","ferredoxin","=","S-","(","2-methylpropanoyl",")","-CoA","+","CO2","+","reduced","ferredoxin","."),4327477). assertion_content_comment('oboGo_Number3_Methyl_2_OxobutanoateDehydrogenaseLipoamideComplex',s("A","protein","complex","that","catalyzes","the","reaction","3-methyl-2-oxobutanoate","+","lipoamide","=","S-","(","2-methylpropanoyl",")","-dihydrolipoamide","+","carbon","dioxide","(","CO2",")","This","requires","thiamine","diphosphate",";","the","enzyme","also","acts","on","(","S",")","-3-methyl-2-oxopentanoate","and","4-methyl-2-oxo-pentanoate","."),4040901). assertion_content_comment('oboGo_Number3_Methyl_2_OxobutanoateDehydrogenaseLipoamide_PhosphataseActivity',s("Catalysis","of","the","reaction",":","H2O","+","[","3-methyl-2-oxobutanoate","dehydrogenase","(","lipoamide",")","]","phosphate","=","phosphate","+","[","3-methyl-2-oxobutanoate","dehydrogenase","(","lipoamide",")","]"),4368658). assertion_content_comment('oboGo_Number3_Methyl_2_OxobutanoateHydroxymethyltransferaseActivity',s("Catalysis","of","the","reaction",":","5",",","10-methylenetetrahydrofolate","+","3-methyl-2-oxobutanoate","=","tetrahydrofolate","+","2-dehydropantoate","."),4189231). assertion_content_comment('oboGo_Number3_Methyl_5_Hydroxy_6_3_Carboxy_3_Oxopropenyl_1H_2_PyridonHydratase_AldolaseActivity',s("Catalysis","of","the","reaction",":","3-methyl-5-hydroxy-6-","(","3-carboxy-3-oxopropenyl",")","-1H-2-pyridon","+","H2O","=","2-oxobut-3-enanoate","+","2",",","5",",","6-trihydroxy-3-methylpyridine","."),4273958). assertion_content_comment('oboGo_Number3Methylbutanol_Nadoxidoreductaseactivity',s("Catalysis","of","the","reaction",":","3-methylbutanol","+","NAD","+","=","3-methylbutanal","+","NADH","+","H","+","3-methylbutanal","is","also","known","as","isovaleraldehyde","."),4191404). assertion_content_comment('oboGo_Number3_Methylbutanol_NADPOxidoreductaseActivity_1',s("Catalysis","of","the","reaction",":","3-methylbutanol","+","NAD","(","P",")","+","=","3-methylbutanal","+","NAD","(","P",")","H","+","H","+","3-methylbutanal","is","also","known","as","isovaleraldehyde","."),4358743). assertion_content_comment('oboGo_Number3Methylbutanol_Nadpoxidoreductaseactivity',s("Catalysis","of","the","reaction",":","3-methylbutanol","+","NADP","+","=","3-methylbutanal","+","NADPH","+","H","+","3-methylbutanal","is","also","known","as","isovaleraldehyde","."),4191368). assertion_content_comment('oboGo_Number3MethylcrotonylCoacarboxylasecomplexmitochondrial',s("A","heterodimeric","complex","having","3-methylcrotonyl-CoA","carboxylase","activity",".","The","alpha","subunit","has","a","covalently","bound","biotin","essential","for","the","ATP-dependent","carboxylation",".","The","beta","subunit","possess","carboxyltransferase","activity","which","presumably","is","essential","for","binding","to","3-methylcrotonyl-CoA","."),4376003). assertion_content_comment('oboGo_Number3Methyleneoxindolereductaseactivity',s("Catalysis","of","the","reaction",":","3-methyloxindole","+","NADP","(","+",")","=","3-methyleneoxindole","+","H","(","+",")","+","NADPH","."),4370948). assertion_content_comment('oboGo_Number3Methylquercitin7OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","3","'",",","4","'",",","5",",","7-tetrahydroxy-3-methoxyflavone","+","S-adenosyl-L-methionine","(","1","+",")","=","3","'",",","4","'",",","5-trihydroxy-3",",","7-dimethoxyflavone","+","S-adenosyl-L-homocysteine","."),4308604). assertion_content_comment('oboGo_Number3Methylquinolinecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","3-methylquinoline",",","C10H9N",",","an","aromatic","compound","composed","of","a","benzene","ring","and","a","heterocyclic","N-containing","ring","."),4240548). assertion_content_comment('oboGo_Number3Methylquinolinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","3-methylquinoline",",","C10H9N",",","an","aromatic","compound","composed","of","a","benzene","ring","and","a","heterocyclic","N-containing","ring","."),4240543). assertion_content_comment('oboGo_Number3Methylsalicylaldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","3-methylsalicylaldehyde","+","NAD","+","=","3-methylsalicylate","+","NADH","+","H","+"),4352723). assertion_content_comment('oboGo_Number3MethylthiopropylDesulfoglucosinolatesulfotransferaseactivity',s("Catalysis","of","the","reaction",":","3-methylthiopropyl-desulfoglucosinolate","+","3","'","-phosphoadenosine","5","'","-phosphosulfate","=","3-methylthiopropyl-glucosinolate","+","adenosine","3","'",",","5","'","-bisphosphate","."),4182788). assertion_content_comment('oboGo_Number3MethylthiopropylglucosinolatesOxygenaseactivity',s("Catalysis","of","the","conversion","of","3-methylthiopropyl","glucosinolate","to","3-methylsulfinylpropyl","glucosinolate","."),4181515). assertion_content_comment('oboGo_Number3Monobromobisphenolareductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","3-monobromobisphenol","A","+","2","H","+","+","2","e-","=","bisphenol","A","+","HBr","."),4352777). assertion_content_comment('oboGo_Number3NFormylFormiminopyruvatehydrolaseactivity',s("Catalysis","of","the","reaction",":","3-","(","N-formyl",")","-formiminopyruvate","+","H2O","=","3-formiminopyruvate","+","formate","."),4350169). assertion_content_comment('oboGo_Number3Nitrophenolnitroreductaseactivity',s("Catalysis","of","the","reaction",":","3-nitrophenol","+","2","NADH","+","2","H","+","=","3-hydroxyaminophenol","+","2","NAD","+","+","H2O","."),4348669). assertion_content_comment('oboGo_Number3Nucleotidaseactivity',s("Catalysis","of","the","reaction",":","a","3","'","-ribonucleotide","+","H2O","=","a","ribonucleoside","+","phosphate","."),4256056). assertion_content_comment('oboGo_Number3_Octaprenyl_4_HydroxybenzoateCarboxy_LyaseActivity',s("Catalysis","of","the","reaction",":","3-octaprenyl-4-hydroxy","benzoate","=","2-octaprenylphenol","+","CO2","."),4251182). assertion_content_comment('oboGo_Number3_Oxo_2_2_PentenylCyclopentane_1_OctanoicAcidCoALigaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","3-oxo-2-","(","2","'","-pentenyl",")","-cyclopentane-1-octanoic","acid","+","coenzyme","A","=","AMP","+","diphosphate","+","3-oxo-2-","(","2","'","-pentenyl",")","-cyclopentane-1-octanoyl-CoA","+","H","+","3-oxo-2-","(","2","'","-pentenyl",")","-cyclopentane-1-octanoic","acid","is","also","known","as","OPC-8",":","0","."),4333397). assertion_content_comment('oboGo_Number3_Oxo_5_Alpha_Steroid4_DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","a","3-oxo-5-alpha-steroid","+","acceptor","=","a","3-oxo-delta","(","4",")","-steroid","+","reduced","acceptor","."),4189257). assertion_content_comment('oboGo_Number3_Oxo_5_Beta_Steroid4_DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","a","3-oxo-5-beta-steroid","+","acceptor","=","a","3-oxo-D4-steroid","+","reduced","acceptor","."),4370935). assertion_content_comment('oboGo_Number3OxoacidcoaTransferaseactivity',s("Catalysis","of","the","reaction",":","succinyl-CoA","+","a","3-oxo","acid","=","succinate","+","a","3-oxo-acyl-CoA","."),4256209). assertion_content_comment('oboGo_Number3OxoacylAcylCarrierProteinreductasenadhactivity',s("Catalysis","of","the","reaction",":","NAD","+","+","OH-acyl-","[","acyl-carrier","protein","]","=","NADH","+","H","+","+","B-ketoacyl-","[","acyl-carrier","protein","]"),4363959). assertion_content_comment('oboGo_Number3OxoacylAcylCarrierProteinreductasenadphactivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-hydroxyacyl-","[","acyl-carrier","protein","]","+","NADP","+","=","3-oxoacyl-","[","acyl-carrier","protein","]","+","NADPH","+","H","+"),4208899). assertion_content_comment('oboGo_Number3OxoacylAcylCarrierProteinsynthaseactivity',s("Catalysis","of","the","reaction",":","acyl-","[","acyl-carrier","protein","]","+","malonyl-","[","acyl-carrier","protein","]","=","3-oxoacyl-","[","acyl-carrier","protein","]","+","CO2","+","[","acyl-carrier","protein","]"),4208864). assertion_content_comment('oboGo_Number3OxoadipatecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","succinyl-CoA","+","3-oxoadipate","=","succinate","+","3-oxoadipyl-CoA","."),4370922). assertion_content_comment('oboGo_Number3OxoadipateenolLactonaseactivity',s("Catalysis","of","the","reaction",":","3-oxoadipate","enol-lactone","+","H2O","=","3-oxoadipate","."),4370647). assertion_content_comment('oboGo_Number3OxoadipylCoathiolaseactivity',s("Catalysis","of","the","reaction",":","succinyl-CoA","+","acetyl-CoA","=","CoA","+","3-oxoadipyl-CoA","."),4343033). assertion_content_comment('oboGo_Number3OxoDelta45Steroid5BetaReductaseactivity',s("Definition",":","Catalysis","of","the","reaction",":","a","3-oxo-delta-4",",","5-steroid","+","NADPH","+","H","(","+",")","=","a","5-beta-3-oxo-steroid","+","NADP","(","+",")"),4380273). assertion_content_comment('oboGo_Number3Oxolauratedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","3-oxolaurate","+","H","(","+",")","=","2-undecanone","+","CO","(","2",")"),4266660). assertion_content_comment('oboGo_Number3Oxosteroid1Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","a","3-oxosteroid","+","acceptor","=","a","3-oxo-D1-steroid","+","reduced","acceptor","."),4370663). assertion_content_comment('oboGo_Number3Phenanthrolsulfotransferaseactivity',s("Catalysis","of","the","reaction",":","3-phenanthrol","+","X-SO3","(","-",")","=","HX","+","3-phenanthrylsulfate","."),4275146). assertion_content_comment('oboGo_Number3Phenylpropionatecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","3-phenylpropionate",",","the","anion","of","phenylpropanoic","acid","."),4239725). assertion_content_comment('oboGo_Number3Phenylpropionatedioxygenaseactivity',s("Catalysis","of","the","reaction",":","3-phenylpropionate","+","NADH","+","H","+","+","O2","=","NAD","+","+","cis-3-","(","3-carboxyethyl",")","-3",",","5-cyclohexadiene-1",",","2-diol","."),4251167). assertion_content_comment('oboGo_Number3Phenylpropionatedioxygenasecomplex',s("Enzyme","complex","consisting","of","four","proteins",":","the","two","subunits","of","the","hydroxylase","component","(","hcaE","and","hcaF",")",",","a","ferredoxin","(","hcaC",")","and","a","ferredoxin","reductase","(","hcaD",")","Converts","3-phenylpropionic","acid","(","PP",")","into","cis-3-","(","3-carboxyethyl",")","-3",",","5-cyclohexadiene-1",",","2-diol","(","PP-dihydrodiol",")"),4259716). assertion_content_comment('oboGo_Number3Phenylpropionatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","3-phenylpropionate",",","the","anion","of","phenylpropanoic","acid",".","It","is","produced","from","putrefaction","of","proteins","in","soil","or","breakdown","of","several","constituents","of","plants",",","such","as","lignin",",","various","oils","and","resins","."),4239717). assertion_content_comment('oboGo_Number3Phenylpropionicacidtransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","3-phenylpropionic","acid","from","one","side","of","the","membrane","to","the","other","."),4314929). assertion_content_comment('oboGo_Number3Phenylpropionicacidtransport',s("The","directed","movement","of","3-phenylpropionic","acid","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4314942). assertion_content_comment('oboGo_Number3Phosphoadenosine5Phosphosulfatebinding',s("Interacting","selectively","and","non-covalently","with","3","'","-phosphoadenosine","5","'","-phosphosulfate","(","PAPS",")",",","a","naturally","occurring","mixed","anhydride",".","It","is","an","intermediate","in","the","formation","of","a","variety","of","sulfo","compounds","in","biological","systems","."),4277582). assertion_content_comment('oboGo_Number3Phosphoadenosine5Phosphosulfatebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","3","'","-phosphoadenosine","5","'","-phosphosulfate",",","a","naturally","occurring","mixed","anhydride",".","It","is","an","intermediate","in","the","formation","of","a","variety","of","sulfo","compounds","in","biological","systems","."),4266793). assertion_content_comment('oboGo_Number3Phosphoadenosine5Phosphosulfatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","3","'","-phosphoadenosine","5","'","-phosphosulfate",",","a","naturally","occurring","mixed","anhydride",".","It","is","an","intermediate","in","the","formation","of","a","variety","of","sulfo","compounds","in","biological","systems","."),4266780). assertion_content_comment('oboGo_Number3Phosphoadenosine5Phosphosulfatetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","3","'","-phosphoadenosine","5","'","-phosphosulfate",",","a","naturally","occurring","mixed","anhydride","synthesized","from","adenosine","5","'","-phosphosulfate",",","from","one","side","of","a","membrane","to","the","other","."),4361916). assertion_content_comment('oboGo_Number3Phosphoadenosine5Phosphosulfatetransport',s("The","directed","movement","of","3","'","-phosphoadenosine","5","'","-phosphosulfate",",","a","naturally","occurring","mixed","anhydride","synthesized","from","adenosine","5","'","-phosphosulfate",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4361894). assertion_content_comment('oboGo_Number3Phosphoglyceratephosphataseactivity',s("Catalysis","of","the","reaction",":","3-phospho-D-glycerate","+","H","(","2",")","O","=","D-glycerate","+","phosphate","."),4370623). assertion_content_comment('oboGo_Number3PhosphoglyceroylPhosphatePolyphosphatephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","long-chain-polyphosphate","+","3-phospho-D-glyceroyl-phosphate","=","long-chain-polyphosphate","+","3-phosphoglycerate","."),4368289). assertion_content_comment('oboGo_Number3PhosphoinositideDependentproteinkinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","a","protein","=","ADP","+","a","phosphoprotein",".","This","reaction","requires","the","presence","of","a","phosphatidylinositol-3-phosphate","."),4202355). assertion_content_comment('oboGo_Number3PhosphoinositideDependentproteinkinasebinding',s("Interacting","selectively","and","non-covalently","with","a","3-phosphoinositide-dependent","protein","kinase","."),4324700). assertion_content_comment('oboGo_Number3Phosphoshikimate1Carboxyvinyltransferaseactivity',s("Catalysis","of","the","reaction",":","3-phosphoshikimate","+","phosphoenolpyruvate","=","5-O-","(","1-carboxyvinyl",")","-3-phosphoshikimate","+","phosphate","."),4189179). assertion_content_comment('oboGo_Number3Phytaseactivity',s("Catalysis","of","the","reaction",":","myo-inositol","hexakisphosphate","+","H2O","=","D-myo-inositol","1",",","2",",","4",",","5",",","6-pentakisphosphate","+","phosphate","."),4303148). assertion_content_comment('oboGo_Number3Propylmalatesynthaseactivity',s("Catalysis","of","the","reaction",":","glyoxylate","+","H","(","2",")","O","+","pentanoyl-CoA","=","3-propylmalate","+","CoA","+","H","(","+",")"),4267037). assertion_content_comment('oboGo_Number3R_3_Isopropenyl_6_Oxoheptanoate_CoALigaseADP_FormingActivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-isopropenyl-6-oxoheptanoate","+","CoA-SH","+","ATP","=","H2O","+","ADP","+","phosphate","+","(","3R",")","-3-isopropenyl-6-oxoheptanoyl-CoA","."),4191493). assertion_content_comment('oboGo_Number3R_3_Isopropenyl_6_Oxoheptanoate_CoALigaseAMP_FormingActivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-isopropenyl-6-oxoheptanoate","+","CoA-SH","+","ATP","=","H2O","+","AMP","+","diphosphate","+","(","3R",")","-3-isopropenyl-6-oxoheptanoyl-CoA","."),4191504). assertion_content_comment('oboGo_Number3RHydroxyacylCoadehydrataseactivity',s("Catalysis","of","the","reaction",":","3R-hydroxyacyl-CoA","=","2E-enoyl-CoA","+","H2O","."),4182267). assertion_content_comment('oboGo_Number3RHydroxymyristoylAcylCarrierProteindehydrataseactivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-hydroxytetradecanoyl-","[","acyl-carrier","protein","]","=","tetradecenoyl-","[","acyl-carrier","protein","]","+","H2O","."),4253263). assertion_content_comment('oboGo_Number3S4R_34_Dihydroxycyclohexa_15_Diene_14_DicarboxylateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","3S",",","4R",")","-3",",","4-dihydroxycyclohexa-1",",","5-diene-1",",","4-dicarboxylate","+","NAD","(","+",")","=","3",",","4-dihydroxybenzoate","+","CO","(","2",")","+","NADH","."),4365708). assertion_content_comment('oboGo_Number3SCitramalylCoalyaseactivity',s("Catalysis","of","the","reaction",":","(","3S",")","-citramalyl-CoA","=","acetyl-CoA","+","pyruvate","."),4373996). assertion_content_comment('oboGo_Number3Splicesitecleavageexonligation',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4224280). assertion_content_comment('oboGo_Number3Trnaprocessingendoribonucleaseactivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","RNA",",","removing","extra","3","'","nucleotides","from","tRNA","precursor",",","generating","3","'","termini","of","tRNAs",".","A","3","'","-hydroxy","group","is","left","at","the","tRNA","terminus","and","a","5","'","-phosphoryl","group","is","left","at","the","trailer","molecule","."),4317089). assertion_content_comment('oboGo_Number3TyrosylDnaphosphodiesteraseactivity',s("Catalysis","of","the","hydrolysis","of","3","'","-phosphotyrosyl","groups","formed","as","covalent","intermediates","(","in","DNA","backbone","breakage",")","between","DNA","topoisomerase","I","and","DNA","."),4265925). assertion_content_comment('oboGo_Number3UtrMediatedmrnadestabilization',s("An","mRNA","destabilization","process","in","which","one","or","more","RNA-binding","proteins","associate","with","the","3","'","-untranslated","region","(","UTR",")","of","an","mRNA","."),4156262). assertion_content_comment('oboGo_Number3UtrMediatedmrnastabilization',s("An","mRNA","stabilization","process","in","which","one","or","more","RNA-binding","proteins","associate","with","the","3","'","-untranslated","region","(","UTR",")","of","an","mRNA","."),4177957). assertion_content_comment('oboGo_Number4_1_Ethyl_14_Dimethyl_PentylPhenolMonoxygenaseActivity',s("Catalysis","of","the","reaction",":","4-","(","1-ethyl-1",",","4-dimethyl-pentyl",")","phenol","+","O2","+","2","H","+","+","2","e-","=","hydroquinone","+","3",",","6-dimethylheptan-3-ol","."),4351214). assertion_content_comment('oboGo_Number4_2_Carboxyphenyl_2_Oxobut_3_EnoateAldolaseActivity',s("Catalysis","of","the","reaction",":","(","3E",")","-4-","(","2-carboxyphenyl",")","-2-oxobut-3-enoate","=","2-carboxybenzaldehyde","+","pyruvate","."),4274021). assertion_content_comment('oboGo_Number4_2_HydroxyisopropylPhenylureaAmidohydrolaseActivity',s("Catalysis","of","the","reaction",":","4","'","-","(","2-hydroxyisopropyl",")","phenylurea","+","H2O","=","4","'","-","(","2-hydroxyisopropyl",")","phenylaniline","+","carbamic","acid","."),4352615). assertion_content_comment('oboGo_Number4_2_Oxocyclohexyl_2_Hydroxy_Buta_24_DienoateHydrolaseActivity',s("Catalysis","of","the","reaction",":","4-","(","2-oxocyclohexyl",")","-2-hydroxy-buta-2",",","4-dienoate","+","H2O","=","2-hydroxydec-2",",","4-diene-1",",","10-dioate","+","H","+"),4350547). assertion_content_comment('oboGo_Number44DihydroxyAlphaMethylstilbenedioxygenaseactivity',s("Catalysis","of","the","reaction",":","4",",","4","'","-dihydroxy-alpha-methylstilbene","+","O2","=","4-hydroxybenzaldehyde","+","4-hydroxyacetophenone","+","2","H","+","+","2","e-","."),4352561). assertion_content_comment('oboGo_Number44_Dimethyl_3_OxopentanalDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","4",",","4-dimethyl-3-oxopentanal","+","H2O","=","4",",","4-dimethyl-3-oxopentanoate","+","3","H","+","+","2","e-","."),4350793). assertion_content_comment('oboGo_Number44_Dimethyl_3_OxopentanoateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","4",",","4-dimethyl-3-oxopentanoate","+","H","+","=","3",",","3-dimethyl-2-butanone","+","CO2","."),4350811). assertion_content_comment('oboGo_Number44_Dimethyl_9beta19_Cyclopropylsterol_4alpha_MethylOxidaseActivity',s("Catalysis","of","the","reaction",":","4",",","4-dimethyl-9beta",",","19-cyclopropylsterol","+","3","NADPH","+","3","H","+","+","3","O2","=","4-alpha-carboxy",",","4-beta-methyl-9beta",",","19-cyclopropylsterol","+","3","NADP","+","+","3","H2O",".","This","overall","reaction","proceeds","through","a","series","of","three","successive","monooxygenations","of","the","alpha","methyl","group","on","the","C4","carbon","(","CH3","to","CH2OH","to","CHO","to","COOH",")"),4182562). assertion_content_comment('oboGo_Number45Dihydroxybenzoapyrenedioxygenaseactivity',s("Catalysis","of","the","reaction",":","4",",","5-dihydroxybenzo","(","a",")","pyrene","+","O2","=","4",",","5-chrysenedicarboxylate","."),4348977). assertion_content_comment('oboGo_Number45Dihydroxybenzoapyrenemethyltransferaseactivity',s("Catalysis","of","the","reaction",":","4",",","5-dihydroxybenzo","(","a",")","pyrene","+","C1","unit","=","hydroxymethoxybenzo","(","a",")","pyrene","."),4349004). assertion_content_comment('oboGo_Number45Dihydroxyphthalatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","4",",","5-dihydroxyphthalate","=","3",",","4-dihydroxybenzoate","+","CO2","."),4274177). assertion_content_comment('oboGo_Number45Dihydroxypyrenedioxygenaseactivity',s("Catalysis","of","the","reaction",":","4",",","5-dihydroxypyrene","+","O2","=","phenanthrene-4",",","5-dicarboxylate","+","2","H","+"),4350313). assertion_content_comment('oboGo_Number46_Dichloro_3_Methylcatechol12_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","4",",","6-dichloro-3-methylcatechol","+","O2","=","3",",","5-dichloro-3-methyl-cis",",","cis-muconate","+","2","H","+"),4348869). assertion_content_comment('oboGo_Number46Pyruvylatedgalactoseresiduebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","pyruvylated","galactose","residue","4-6-O-","[","(","R",")","(","1-carboxyethylidine",")","]","-Gal-beta-1",",","3-",".","The","galactose","residue","is","part","of","a","larger","polysaccharide","chain","."),4111722). assertion_content_comment('oboGo_Number46Pyruvylatedgalactoseresiduemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","the","pyruvylated","galactose","residue","4-6-O-","[","(","R",")","(","1-carboxyethylidine",")","]","-Gal-beta-1",",","3-",".","The","galactose","residue","is","part","of","a","larger","polysaccharide","chain","."),4111715). assertion_content_comment('oboGo_Number4812_Trimethyltrideca_13711_TetraeneSynthaseActivity',s("Catalysis","of","the","reaction",":","(","EE",")","-geranyllinalool","+","NADPH","+","O2","=","TMTT","+","NADP","+","+","2H2O",".","It","is","unknown","whether","this","reaction","proceeds","by","the","direct","release","of","the","4-carbon","compound","but-1-en-3-one",",","or","whether","the","substrate","is","first","degraded","to","C18-farnesylacetone","and","then","cleaved","to","produce","TMTT","and","acetone","."),4073691). assertion_content_comment('oboGo_Number49Dshahydrolaseactivity',s("Catalysis","of","the","reaction",":","(","3E",",","1Z",")","-4",",","5-9",",","10-diseco-3-hydroxy-5",",","9",",","17-trioxoandrosta-1","(","10",")",",","2-diene-4-oate","+","H2O","=","(","2E",",","4E",")","-2-hydroxyhexa-2",",","4-dienoate","+","9",",","17-dioxo-1",",","2",",","3",",","4",",","10",",","19-hexanorandrostan-5-oate","+","H","+"),4350520). assertion_content_comment('oboGo_Number4Acetamidobutyratedeacetylaseactivity',s("Catalysis","of","the","reaction",":","4-acetamidobutanoate","+","H2O","=","acetate","+","4-aminobutanoate","."),4370636). assertion_content_comment('oboGo_Number4AcetamidobutyrylCoadeacetylaseactivity',s("Catalysis","of","the","reaction",":","4-acetamidobutanoyl-CoA","+","H","(","2",")","O","=","4-aminobutanoyl-CoA","+","acetate","."),4370706). assertion_content_comment('oboGo_Number4Ad9alphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","androst-4-ene-3",",","17-dione","+","O2","+","2","H","+","+","2","e-","=","9alpha-hydroxy-4-androstene-3",",","17-dione","+","H2O","."),4350865). assertion_content_comment('oboGo_Number4_Alpha_D_1_Gt4_Alpha_D_GlucanoTrehaloseTrehalohydrolaseActivity',s("Catalysis","of","the","hydrolysis","of","alpha-","(","1-","&","gt",";","4",")","-D-glucosidic","linkage","in","4-alpha-D-","{","(","1-","&","gt",";","4",")","-alpha-D-glucanosyl","}","n","trehalose","to","yield","trehalose","and","alpha-","(","1-","&","gt",";","4",")","-D-glucan","."),4344420). assertion_content_comment('oboGo_Number4AlphaGlucanotransferaseactivity',s("Catalysis","of","the","transfer","of","a","segment","of","a","(","1",",","4",")","-alpha-D-glucan","to","a","new","4-position","in","an","acceptor",",","which","may","be","glucose","or","(","1",",","4",")","-alpha-D-glucan","."),4211747). assertion_content_comment('oboGo_Number4AlphaHydroxytetrahydrobiopterindehydrataseactivity',s("Catalysis","of","the","reaction",":","(","6R",")","-6-","(","L-erythro-1",",","2-dihydroxypropyl",")","-5",",","6",",","7",",","8-tetrahydro-4a-hydroxypterin","=","(","6R",")","-6-","(","L-erythro-1",",","2-dihydroxypropyl",")","-7",",","8-dihydro-6H-pterin","+","H","(","2",")","O","."),4246649). assertion_content_comment('oboGo_Number4_Alpha_Methyl_Delta7_Sterol_4alpha_MethylOxidaseActivity',s("Catalysis","of","the","reaction",":","4-alpha-methyl-delta7-sterol","+","3","NADPH","+","3","H","+","+","3","O2","=","4-alpha-carboxy",",","delta7-sterol","+","3","NADP","+","+","3","H2O",".","This","overall","reaction","proceeds","through","a","series","of","three","successive","monooxygenations","of","the","alpha","methyl","group","on","the","C4","carbon","(","CH3","to","CH2OH","to","CHO","to","COOH",")"),4182797). assertion_content_comment('oboGo_Number4_Amino_2_Nitroso_6_NitrotolueneReductaseActivity',s("Catalysis","of","the","reaction",":","4-amino-2-hydroxylamino-6-nitrotoluene","+","NADP","+","=","NADPH","+","H","+","+","4-amino-2-nitroso-6-nitrotoluene","."),4279011). assertion_content_comment('oboGo_Number4_Amino_3_IsothiazolidinoneBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","4-amino-3-isothiazolinone",",","five-membered","saturated","heterocyclic","ring","structures","containing","a","sulfur","and","a","nitrogen","in","the","1-position","and","2-positions","respectively","."),4385281). assertion_content_comment('oboGo_Number4_Amino_4_DeoxychorismateLyaseActivity',s("Catalysis","of","the","reaction",":","4-amino-4-deoxychorismate","=","4-aminobenzoate","+","H","(","+",")","+","pyruvate","."),4245824). assertion_content_comment('oboGo_Number4_Amino_4_DeoxychorismateSynthaseActivity',s("Catalysis","of","the","reaction",":","L-glutamine","+","chorismate","=","4-amino-4-deoxychorismate","+","L-glutamate",".","It","is","composed","of","two","enzymatic","activities","(","which","may","be","present","on","one","or","two","polypeptides",")",";","the","first","is","a","glutaminase","which","yields","ammonia","from","glutamine",",","releasing","glutamate",".","The","ammonia","is","used","by","the","second","activity","which","catalyzes","the","amination","of","chorismate","to","form","4-amino-4-deoxychorismate","."),4245844). assertion_content_comment('oboGo_Number4_Amino_5_Hydroxymethyl_2_MethylpyrimidineDiphosphataseActivity',s("Catalysis","of","the","reaction",":","4-amino-5-hydroxymethyl-2-methylpyrimidine","pyrophosphate","+","H2O","=","hydroxymethylpyrimidine","phosphate","+","phosphate","+","H","+"),4375358). assertion_content_comment('oboGo_Number4_Amino_5_Hydroxymethyl_2_MethylpyrimidinePhosphateSynthaseActivity',s("Catalysis","of","the","reaction",":","5-aminoimidazole","ribonucleotide","+","S-adenosylmethionine","=","4-amino-5-hydroxymethyl-2-methylpyrimidine","phosphate","+","5","'","deoxyadenosine","."),4174311). assertion_content_comment('oboGo_Number4Aminobenzenesulfonate34Dioxygenasedeaminatingactivity',s("Catalysis","of","the","reaction",":","4-aminobenzenesulfonate","+","2","H","+","+","O2","+","2","e-","=","NH3","+","4-sulfocatechol","."),4276877). assertion_content_comment('oboGo_Number4Aminobenzoate1Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","4-aminobenzoate","+","NADPH","+","H","+","+","O2","=","4-hydroxyaniline","+","NADP","+","+","H2O","+","CO2","."),4276405). assertion_content_comment('oboGo_Number4Aminobenzoate34Dioxygenasedeaminatingactivity',s("Catalysis","of","the","reaction",":","4-aminobenzoate","+","2","H","+","+","O2","+","2","e-","=","NH3","+","3",",","4-dihydroxybenzoate","."),4276982). assertion_content_comment('oboGo_Number4Aminobenzoateaminoacidsynthetaseactivity',s("Catalysis","of","the","reaction",":","4-aminobenzoate","+","ATP","+","amino","acid","=","4-aminobenzoyl","amino","acid","conjugate","+","AMP","+","diphosphate","."),4191294). assertion_content_comment('oboGo_Number4Aminobutyrate_2Oxoglutaratetransaminaseactivity',s("Catalysis","of","the","reaction",":","4-aminobutanoate","+","2-oxoglutarate","=","succinate","semialdehyde","+","L-glutamate","."),4357063). assertion_content_comment('oboGo_Number4Aminobutyrate_Pyruvatetransaminaseactivity',s("Catalysis","of","the","reaction",":","4-aminobutanoate","+","pyruvate","=","succinate","semialdehyde","+","alanine","."),4357091). assertion_content_comment('oboGo_Number4Aminobutyratetransaminaseactivity',s("Catalysis","of","the","reaction",":","4-aminobutanoate","+","amino","group","acceptor","=","succinate","semialdehyde","+","amino","acid","."),4189193). assertion_content_comment('oboGo_Number4Aminobutyratetransaminasecomplex',s("A","homodimeric","protein","complex","that","possesses","4-aminobutyrate","transaminase","activity","."),4329115). assertion_content_comment('oboGo_Number4_Carboxy_2_Hydroxymuconate_6_SemialdehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","4-carboxy-2-hydroxy-cis",",","cis-muconate","6-semialdehyde","+","NADP","+","=","4-carboxy-2-hydroxy-cis",",","cis-muconate","+","NADPH","+","H","+"),4278301). assertion_content_comment('oboGo_Number4_Carboxy_4_SulfoazobenzeneMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","4-carboxy-4","'","-sulfoazobenzene",",","a","sulfonated","azo","compound","synthesized","by","nitro-amine","condensation","from","sulfanilic","acid","and","4-nitrobenzoic","acid","."),4273402). assertion_content_comment('oboGo_Number4_Carboxy_4_SulfoazobenzeneReductaseActivity',s("Catalysis","of","the","reaction",":","4-carboxy-4","'","-sulfoazobenzene","+","4","H","+","+","4","e-","=","4-aminobenzoate","+","4-aminobenzenesulfonate","."),4279020). assertion_content_comment('oboGo_Number4_Carboxymethyl_4_MethylbutenolideMutaseActivity',s("Catalysis","of","the","reaction",":","4-carboxymethyl-4-methylbut-2-en-1",",","4-olide","=","4-carboxymethyl-3-methylbut-2-en-1",",","4-olide","."),4369542). assertion_content_comment('oboGo_Number4Carboxymuconolactonedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-2-","(","carboxymethyl",")","-5-oxo-2",",","5-dihydro-2-furoate","+","H","(","+",")","=","5-oxo-4",",","5-dihydro-2-furylacetate","+","CO","(","2",")"),4370719). assertion_content_comment('oboGo_Number4Chlorobenzaldehydeoxidaseactivity',s("Catalysis","of","the","reaction",":","4-chlorobenzaldehyde","+","2","H2O","=","4-chlorobenzoate","+","2","H","+","+","2","e-","."),4277529). assertion_content_comment('oboGo_Number4ChlorobenzoateCoaligaseactivity',s("Catalysis","of","the","reaction",":","4-chlorobenzoate","+","CoA","+","ATP","=","4-chlorobenzoyl-CoA","+","AMP","+","diphosphate",".","This","reaction","requires","magnesium","and","is","part","of","the","bacterial","2",",","4-dichlorobenzoate","degradation","pathway","."),4273264). assertion_content_comment('oboGo_Number4Chlorobenzoatedehalogenaseactivity',s("Catalysis","of","the","reaction",":","4-chlorobenzoate","+","H","(","2",")","O","=","4-hydroxybenzoate","+","chloride","+","H","(","+",")"),4370682). assertion_content_comment('oboGo_Number4ChlorobenzoylCoadehalogenaseactivity',s("Catalysis","of","the","reaction",":","4-chlorobenzoyl-CoA","+","H2O","=","4-hydroxybenzoyl","CoA","+","chloride","."),4274240). assertion_content_comment('oboGo_Number4Chlorobiphenylmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","4-chlorobiphenyl",",","a","member","of","the","polychlorinated","biphenyl","(","PCB",")","group","of","compounds",",","a","very","stable","group","of","synthetic","organic","compounds","composed","of","a","biphenyl","nucleus","with","1-10","chlorine","substituents",".","4-chlorobiphenyl","has","been","used","as","a","model","substrate","to","investigate","PCB","degradation","."),4273440). assertion_content_comment('oboGo_Number4Chloronitrobenzenenitroreductaseactivity',s("Catalysis","of","the","reaction",":","4-chloronitrobenzene","+","NADPH","+","H","+","=","1-chloro-4-nitrosobenzene","+","NADP","+","+","H2O","."),4190989). assertion_content_comment('oboGo_Number4Chlorophenoxyacetatemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","4-chlorophenoxyacetate","+","1/2","O2","=","glyoxylate","+","4-chlorophenol","."),4275578). assertion_content_comment('oboGo_Number4Chlorophenylacetate34Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","4-chlorophenylacetate","+","NADH","+","O","(","2",")","=","3",",","4-dihydroxyphenylacetate","+","chloride","+","NAD","(","+",")"),4276103). assertion_content_comment('oboGo_Number4CoumarateCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","4-coumarate","+","CoA","=","AMP","+","diphosphate","+","4-coumaroyl-CoA","."),4303860). assertion_content_comment('oboGo_Number4Cresoldehydrogenasehydroxylatingactivity',s("Catalysis","of","the","reaction",":","4-cresol","+","acceptor","+","H2O","=","4-hydroxybenzaldehyde","+","reduced","acceptor","."),4276655). assertion_content_comment('oboGo_Number4_Cytidine5_Diphospho_2_C_Methyl_D_ErythritolKinaseActivity',s("Catalysis","of","the","reaction",":","4-CDP-2-C-methyl-D-erythritol","+","ATP","=","4-CDP-2-C-methyl-D-erythritol","2-phosphate","+","ADP","+","2","H","(","+",")"),4269155). assertion_content_comment('oboGo_Number4_Deoxy_L_Threo_5_Hexosulose_UronateKetol_IsomeraseActivity',s("Catalysis","of","the","reaction",":","5-dehydro-4-deoxy-D-glucuronate","=","3-deoxy-D-glycero-2",",","5-hexodiulosonate","."),4251155). assertion_content_comment('oboGo_Number4Dimethylaminophenylazoxybenzenereductaseactivity',s("Catalysis","of","the","reaction",":","4-","(","dimethylamino",")","azobenzene","+","H","(","2",")","O","+","NADP","(","+",")","=","4-","(","dimethylamino",")","phenylazoxybenzene","+","H","(","+",")","+","NADPH","."),4365563). assertion_content_comment('oboGo_Number4Formylbenzenesulfonatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-formylbenzenesulfonate","+","H","(","2",")","O","+","NAD","(","+",")","=","4-sulfobenzoate","+","2","H","(","+",")","+","NADH","."),4277115). assertion_content_comment('oboGo_Number4GalactosylNAcetylglucosaminide3AlphaLFucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","GDP-beta-L-fucose","+","beta-D-galactosyl-","(","1",",","4",")","-N-acetyl-D-glucosaminyl-R","=","GDP","+","1",",","4-beta-D-galactosyl-","(","1",",","4",")","-","[","alpha-L-fucosyl-","(","1",",","4",")","]","-N-acetyl-D-glucosaminyl-R","."),4269095). assertion_content_comment('oboGo_Number4_Hydroxy_2_KetopimelateAldolaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxy-2-ketopimelate","=","succinate","semialdehyde","+","pyruvate","."),4327002). assertion_content_comment('oboGo_Number4_Hydroxy_2_OxoglutarateAldolaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxy-2-oxoglutarate","=","pyruvate","+","glyoxylate","."),4252027). assertion_content_comment('oboGo_Number4_Hydroxy_2_OxovalerateAldolaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxy-2-oxopentanoate","=","acetaldehyde","+","pyruvate","."),4252010). assertion_content_comment('oboGo_Number4_Hydroxy_3_Methylbut_2_En_1_YlDiphosphateReductaseActivity',s("Catalysis","of","the","reaction",":","(","E",")","-4-hydroxy-3-methylbut-2-en-1-yl","diphosphate","+","NAD","(","P",")","H","+","H","+","=","isopentenyl","diphosphate","+","NAD","(","P",")","+","+","H2O",".","Note","that","(","E",")","-4-hydroxy-3-methylbut-2-en-1-yl","diphosphate","is","an","alternative","name","for","1-hydroxy-2-methyl-2-","(","E",")","-butenyl","4-diphosphate","."),4279842). assertion_content_comment('oboGo_Number4_Hydroxy_3_Methylbut_2_En_1_YlDiphosphateSynthaseActivity',s("Catalysis","of","the","reaction",":","(","E",")","-4-hydroxy-3-methylbut-2-en-1-yl","diphosphate","+","H2O","+","2","oxidized","ferredoxin","=","2-C-methyl-D-erythritol","2",",","4-cyclodiphosphate","+","2","reduced","ferredoxin","."),4351233). assertion_content_comment('oboGo_Number4_Hydroxy_4_Methyl_2_OxoglutarateAldolaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxy-4-methyl-2-oxoglutarate","=","2","pyruvate","."),4370173). assertion_content_comment('oboGo_Number4Hydroxyacetophenonemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","4","'","-hydroxyacetophenone","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","4-hydroxyphenyl","acetate","+","H","(","2",")","O","+","NADP","(","+",")"),4342170). assertion_content_comment('oboGo_Number4Hydroxybenzaldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzaldehyde","+","NAD","+","+","H2O","=","4-hydroxybenzoate","+","NADH","+","H","+"),4277138). assertion_content_comment('oboGo_Number4Hydroxybenzoate1Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzoate","+","NADPH","+","H","+","+","O2","=","hydroquinone","+","NADP","+","+","H2O","+","CO2","."),4276464). assertion_content_comment('oboGo_Number4Hydroxybenzoate3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzoate","+","NADPH","+","H","+","+","O2","=","protocatechuate","+","NADP","+","+","H2O","."),4276183). assertion_content_comment('oboGo_Number4Hydroxybenzoate3Monooxygenasenadphactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzoate","+","NAD","(","P",")","H","+","H","+","+","O2","=","3",",","4-dihydroxybenzoate","+","NAD","(","P",")","+","+","H2O","."),4276418). assertion_content_comment('oboGo_Number4Hydroxybenzoate4OBetaDGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzoate","+","UDP-D-glucose","=","4-","(","beta-D-glucosyloxy",")","benzoate","+","H","(","+",")","+","UDP","."),4367154). assertion_content_comment('oboGo_Number4Hydroxybenzoateaminoacidsynthetaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzoate","+","ATP","+","amino","acid","=","4-hydroxybenzoyl","amino","acid","conjugate","+","AMP","+","diphosphate","."),4191163). assertion_content_comment('oboGo_Number4HydroxybenzoateCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","4-hydroxybenzoate","+","CoA","=","AMP","+","diphosphate","+","4-hydroxybenzoyl-CoA","."),4273772). assertion_content_comment('oboGo_Number4Hydroxybenzoatedecaprenyltransferaseactivity',s("Catalysis","of","the","reaction",":","all-trans-decaprenyl","diphosphate","+","4-hydroxybenzoate","=","3-decaprenyl-4-hydroxybenzoate","+","diphosphate","."),4373342). assertion_content_comment('oboGo_Number4Hydroxybenzoatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzoate","+","H","(","+",")","=","CO","(","2",")","+","phenol","."),4274146). assertion_content_comment('oboGo_Number4Hydroxybenzoatenonaprenyltransferaseactivity',s("Catalysis","of","the","reaction",":","p-hydroxybenzoate","+","solanesyl","pyrophosphate","=","nonaprenyl-4-hydroxybenzoate","+","diphosphate","."),4367638). assertion_content_comment('oboGo_Number4Hydroxybenzoateoctaprenyltransferaseactivity',s("Catalysis","of","the","reaction",":","farnesylfarnesylgeranyl","diphosphate","+","p-hydroxybenzoate","=","3-octaprenyl-4-hydroxybenzoate","+","diphosphate","."),4255722). assertion_content_comment('oboGo_Number4HydroxybenzoylCoareductaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzoyl-CoA","+","acceptor","=","benzoyl-CoA","+","reduced","acceptor","."),4278381). assertion_content_comment('oboGo_Number4HydroxybenzoylCoathioesteraseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybenzoyl-CoA","+","H","(","2",")","O","=","4-hydroxybenzoate","+","CoA","+","H","(","+",")"),4275059). assertion_content_comment('oboGo_Number4HydroxybutanoylCoadehydrataseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybutanoyl-CoA","=","vinylacetyl-CoA","+","H2O","."),4325816). assertion_content_comment('oboGo_Number4Hydroxybutaraldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybutyraldehyde","+","H2O","=","2","H","+","+","2","e-","+","4-hydroxybutanoate","."),4277608). assertion_content_comment('oboGo_Number4HydroxybutyratecoaTransferaseactivity',s("Catalysis","of","the","transfer","of","a","coenzyme","A","(","CoA",")","group","to","4-hydroxybutyrate","."),4255685). assertion_content_comment('oboGo_Number4Hydroxybutyratedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxybutanoate","+","NAD","(","+",")","=","H","(","+",")","+","NADH","+","succinate","semialdehyde","."),4370694). assertion_content_comment('oboGo_Number4Hydroxycatechol12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","O2","+","benzene-1",",","2",",","4-triol","=","maleylacetate","."),4365150). assertion_content_comment('oboGo_Number4Hydroxycyclohexanecarboxylatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","trans-4-hydroxycyclohexanecarboxylate","+","NAD","(","+",")","=","4-oxocyclohexanecarboxylate","+","H","(","+",")","+","NADH","."),4364349). assertion_content_comment('oboGo_Number4Hydroxyglutamatetransaminaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxy-L-glutamate","+","2-oxoglutarate","=","4-hydroxy-2-oxoglutarate","+","L-glutamate","."),4370732). assertion_content_comment('oboGo_Number4Hydroxymandelateoxidaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-4-hydroxymandelate","+","H","(","+",")","+","O","(","2",")","=","4-hydroxybenzaldehyde","+","CO","(","2",")","+","H","(","2",")","O","(","2",")"),4370743). assertion_content_comment('oboGo_Number4Hydroxymandelatesynthaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxyphenylpyruvate","+","O2","=","4-hydroxymandelate","+","CO2","."),4268087). assertion_content_comment('oboGo_Number4Hydroxymethylbenzenesulfonatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-","(","hydroxymethyl",")","benzenesulfonate","+","NAD","(","+",")","=","4-formylbenzenesulfonate","+","H","(","+",")","+","NADH","."),4277412). assertion_content_comment('oboGo_Number4Hydroxymethylsalicyaldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxymethylsalicylaldehyde","+","NAD","+","+","H2O","=","4-hydroxymethylsalicylate","+","NADH","+","2","H","+"),4352147). assertion_content_comment('oboGo_Number4HydroxymuconicSemialdehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","&","lt",";","stereo","&","gt",";","cis",",","trans","&","lt",";","/stereo","&","gt",";","-4-hydroxymuconate","semialdehyde","+","H","(","2",")","O","+","NAD","(","+",")","=","2","H","(","+",")","+","maleylacetate","+","NADH","."),4277221). assertion_content_comment('oboGo_Number4Hydroxyphenylacetaldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NAD","+","+","(","4-hydroxyphenyl",")","acetaldehyde","+","H2O","=","NADH","+","4-hydroxyphenylacetate","."),4366038). assertion_content_comment('oboGo_Number4HydroxyphenylacetaldehydeOximeisomeraseactivity',s("Catalysis","of","the","reaction",":","(","E",")","-4-hydroxyphenylacetaldehyde","oxime","=","(","Z",")","-4-hydroxyphenylacetaldehyde","oxime","."),4369522). assertion_content_comment('oboGo_Number4Hydroxyphenylacetaldehydeoximemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","(","Z",")","-","(","4-hydroxyphenyl",")","acetaldehyde","oxime","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","(","S",")","-4-hydroxymandelonitrile","+","2","H","(","2",")","O","+","NADP","(","+",")"),4267978). assertion_content_comment('oboGo_Number4Hydroxyphenylacetate1Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxyphenylacetate","+","NADPH","+","H","+","+","O2","=","homogentisate","+","NADP","+","+","H2O","."),4276502). assertion_content_comment('oboGo_Number4Hydroxyphenylacetate3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxyphenylacetate","+","NADH","+","H","+","+","O2","=","3",",","4-dihydroxyphenylacetate","+","NAD","+","+","H2O","."),4276541). assertion_content_comment('oboGo_Number4Hydroxyphenylacetatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","(","4-hydroxyphenyl",")","acetate","+","H","(","+",")","=","4-cresol","+","CO","(","2",")"),4325801). assertion_content_comment('oboGo_Number4Hydroxyphenylpyruvatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","(","4-hydroxyphenyl",")","pyruvate","+","H","(","+",")","=","(","4-hydroxyphenyl",")","acetaldehyde","+","CO","(","2",")"),4268840). assertion_content_comment('oboGo_Number4Hydroxyphenylpyruvatedioxygenaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxyphenylpyruvate","+","O2","=","homogentisate","+","CO2","."),4189811). assertion_content_comment('oboGo_Number4Hydroxyphenylpyruvateoxidaseactivity',s("Catalysis","of","the","reaction",":","2","(","4-hydroxyphenyl",")","pyruvate","+","O","(","2",")","=","2","(","4-hydroxyphenyl",")","acetate","+","2","CO","(","2",")"),4277371). assertion_content_comment('oboGo_Number4Hydroxyprolinebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","4-hydroxyproline",",","C5H9NO3",",","a","derivative","of","the","amino","acid","proline","."),4241399). assertion_content_comment('oboGo_Number4Hydroxyprolinecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","4-hydroxyproline",",","C5H9NO3",",","a","derivative","of","the","amino","acid","proline","."),4241281). assertion_content_comment('oboGo_Number4Hydroxyprolineepimeraseactivity',s("Catalysis","of","the","reaction",":","trans-4-hydroxy-L-proline","=","cis-4-hydroxy-D-proline","."),4370754). assertion_content_comment('oboGo_Number4Hydroxyprolinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","4-hydroxyproline",",","C5H9NO3",",","a","derivative","of","the","amino","acid","proline",".","The","presence","of","hydroxyproline","is","essential","to","produce","stable","triple","helical","tropocollagen",",","hence","the","problems","caused","by","ascorbate","deficiency","in","scurvy",".","This","unusual","amino","acid","is","also","present","in","considerable","amounts","in","the","major","glycoprotein","of","primary","plant","cell","walls","."),4241267). assertion_content_comment('oboGo_Number4_Hydroxypyridine_3_HydroxylaseActivity',s("Catalysis","of","the","reaction",":","4-hydroxypyridine","+","O2","+","H","+","+","NADPH","=","pyridine-3",",","4-diol","+","H2O","+","NADP","+"),4351187). assertion_content_comment('oboGo_Number4Hydroxyquinoline3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADH","+","O","(","2",")","+","quinolin-4-ol","=","H","(","2",")","O","+","NAD","(","+",")","+","quinoline-3",",","4-diol","."),4364587). assertion_content_comment('oboGo_Number4_Hydroxythreonine_4_PhosphateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","4-","(","phosphonooxy",")","-threonine","+","NAD","+","=","2-amino-3-oxo-4-phosphonooxybutyrate","+","NADH","+","H","+"),4268543). assertion_content_comment('oboGo_Number4_Isopropenyl_2_Ketocyclohexane_1_Carboxyl_CoAHydrolaseActivity',s("Catalysis","of","the","reaction",":","4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA","+","H2O","=","3-isopropenylpimelyl-CoA","."),4349785). assertion_content_comment('oboGo_Number4Isopropylanilinedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-isopropylaniline","+","H2O","=","4","'","-","(","2-hydroxyisopropyl",")","phenylaniline","+","2","H","+","+","2","e-","."),4352633). assertion_content_comment('oboGo_Number4Ketotorulene3Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","4-ketotorulene","+","a","reduced","electron","acceptor","+","oxygen","=","3-hydroxy-4-ketotorulene","+","an","oxidized","electron","acceptor","+","H2O","."),4190921). assertion_content_comment('oboGo_Number4MethoxybenzoatemonooxygenaseoDemethylatingactivity',s("Catalysis","of","the","reaction",":","4-methoxybenzoate","+","AH","(","2",")","+","O","(","2",")","=","4-hydroxybenzoate","+","A","+","formaldehyde","+","H","(","2",")","O","."),4276619). assertion_content_comment('oboGo_Number4Methoxyisoflavone2Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","formononetin","+","NADPH","+","O2","=","2","'","-hydroxyformononetin","+","NADP","+","+","H2O","."),4377742). assertion_content_comment('oboGo_Number4MethyleneglutamateAmmonialigaseactivity',s("Catalysis","of","the","reaction",":","4-methylene-L-glutamate","+","ATP","+","NH","(","4",")","(","+",")","=","4-methylene-L-glutamine","+","AMP","+","diphosphate","+","2","H","(","+",")"),4370768). assertion_content_comment('oboGo_Number4Methyleneglutaminaseactivity',s("Catalysis","of","the","reaction",":","4-methylene-L-glutamine","+","H","(","2",")","O","=","4-methylene-L-glutamate","+","NH","(","4",")","(","+",")"),4370779). assertion_content_comment('oboGo_Number4_Methyloct_2_Enoyl_CoAHydrataseActivity',s("Catalysis","of","the","reaction",":","4-methyloct-2-enoyl-CoA","+","H2O","=","3-hydroxy-4-methyloctanoyl-CoA","."),4352416). assertion_content_comment('oboGo_Number4MethyloctanoylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-methyloctanoyl-CoA","=","4-methyloct-2-enoyl-CoA","+","2","H","+","+","2","e-","."),4352407). assertion_content_comment('oboGo_Number4Methyloxaloacetateesteraseactivity',s("Catalysis","of","the","reaction",":","4-methoxy-2",",","4-dioxobutanoate","+","H","(","2",")","O","=","H","(","+",")","+","methanol","+","oxaloacetate","."),4370791). assertion_content_comment('oboGo_Number4MethylthiobutylDesulfoglucosinolatesulfotransferaseactivity',s("Catalysis","of","the","reaction",":","4-methylthiobutyl-desulfoglucosinolate","+","3","'","-phosphoadenosine","5","'","-phosphosulfate","=","4-methylthiobutyl-glucosinolate","+","adenosine","3","'",",","5","'","-bisphosphate","."),4182815). assertion_content_comment('oboGo_Number4MethylthiopropylglucosinolatesOxygenaseactivity',s("Catalysis","of","the","conversion","of","4-methylthiopropyl","glucosinolate","to","4-methylsulfinylpropyl","glucosinolate","."),4181506). assertion_content_comment('oboGo_Number4MethylumbelliferylBetaDGlucopyranosidebetaGlucosidaseactivity',s("Catalysis","of","the","hydrolysis","of","glucosidic","link","in","4-methylumbelliferyl-beta-D-glucopyranoside","."),4182416). assertion_content_comment('oboGo_Number4Nitrocatechol4Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","4-nitrocatechol","+","O2","+","4","e-","+","3","H","+","=","H2O","+","nitrite","+","1",",","2",",","4-benzenetriol","."),4275588). assertion_content_comment('oboGo_Number4Nitrophenol2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","4-nitrophenol","+","H","(","+",")","+","NADH","+","O","(","2",")","=","4-nitrocatechol","+","H","(","2",")","O","+","NAD","(","+",")"),4276952). assertion_content_comment('oboGo_Number4Nitrophenol4Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","p-nitrophenol","+","O2","+","NADPH","=","H2O","+","NADP","+","+","nitrite","+","p-benzoquinone","."),4275971). assertion_content_comment('oboGo_Number4Nitrophenolbiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","4-nitrophenol",",","a","nitroaromatic","compound","which","is","used","in","the","production","of","dyes",",","leather","treatment","agents",",","fungicides","and","as","an","intermediate","in","the","production","of","the","insecticide","parathion","."),4351730). assertion_content_comment('oboGo_Number4Nitrophenolcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","4-nitrophenol",",","a","nitroaromatic","compound","which","is","used","in","the","production","of","dyes",",","leather","treatment","agents",",","fungicides","and","as","an","intermediate","in","the","production","of","the","insecticide","parathion","."),4351716). assertion_content_comment('oboGo_Number4Nitrophenolmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","4-nitrophenol",",","a","nitroaromatic","compound","which","is","used","in","the","production","of","dyes",",","leather","treatment","agents",",","fungicides","and","as","an","intermediate","in","the","production","of","the","insecticide","parathion","."),4272524). assertion_content_comment('oboGo_Number4Nitrophenylphosphataseactivity',s("Catalysis","of","the","reaction",":","4-nitrophenyl","phosphate","+","H2O","=","4-nitrophenol","+","phosphate","."),4189792). assertion_content_comment('oboGo_Number4Nitrotoluenebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","4-nitrotoluene",",","1-methyl-4-nitrobenzene","."),4353262). assertion_content_comment('oboGo_Number4Nitrotoluenecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","4-nitrotoluene",",","1-methyl-4-nitrobenzene","."),4238022). assertion_content_comment('oboGo_Number4Nitrotoluenemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","4-nitrotoluene",",","1-methyl-4-nitrobenzene",".","It","is","a","light","yellow","liquid","with","a","weak","aromatic","odor","."),4238002). assertion_content_comment('oboGo_Number4Oxalmesaconatehydrataseactivity',s("Catalysis","of","the","reaction",":","2-hydroxy-4-oxobutane-1",",","2",",","4-tricarboxylate","=","(","1E",")","-4-oxobut-1-ene-1",",","2",",","4-tricarboxylate","+","H","(","2",")","O","."),4370802). assertion_content_comment('oboGo_Number4Oxalocrotonatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","4-oxalocrotonate","=","CO2","+","2-oxopent-4-enoate","."),4370377). assertion_content_comment('oboGo_Number4Oxoprolinereductaseactivity',s("Catalysis","of","the","reaction",":","4-hydroxy-L-proline","+","NAD","+","=","4-oxoproline","+","NADH","+","H","+"),4305878). assertion_content_comment('oboGo_Number4Phenanthrolsulfotransferaseactivity',s("Catalysis","of","the","reaction",":","4-phenanthrol","+","X-SO3","(","-",")","=","HX","+","4-phenanthrylsulfate","."),4275156). assertion_content_comment('oboGo_Number4Phosphoerythronatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","4-phospho-D-erythronate","+","NAD","(","+",")","=","(","R",")","-3-hydroxy-2-oxo-4-phosphonooxybutanoate","+","H","(","+",")","+","NADH","."),4341999). assertion_content_comment('oboGo_Number4Phytaseactivity',s("Catalysis","of","the","reaction",":","myo-inositol","hexakisphosphate","+","H2O","=","1-myo-inositol","1",",","2",",","3",",","4",",","5-pentakisphosphate","+","phosphate","."),4251907). assertion_content_comment('oboGo_Number4Pyridoxolactonaseactivity',s("Catalysis","of","the","reaction",":","4-pyridoxolactone","+","H","(","2",")","O","=","4-pyridoxate","+","H","(","+",")"),4370817). assertion_content_comment('oboGo_Number4SLimonenesynthaseactivity',s("Catalysis","of","the","reaction",":","geranyl","diphosphate","=","limonene","+","diphosphate","."),4268131). assertion_content_comment('oboGo_Number4Sulfobenzoate34Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","4-sulfobenzoate","+","H","(","+",")","+","NADH","+","O","(","2",")","=","3",",","4-dihydroxybenzoate","+","NAD","(","+",")","+","sulfite","."),4276113). assertion_content_comment('oboGo_Number4Toluenecarboxylatebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","4-toluenecarboxylate",",","4-methylbenzenecarboxylate",",","the","anion","of","carboxylic","acid","attached","to","a","methylbenzene","molecule","."),4353415). assertion_content_comment('oboGo_Number4Toluenecarboxylatecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","4-toluenecarboxylate",",","4-methylbenzenecarboxylate",",","the","anion","of","carboxylic","acid","attached","to","a","methylbenzene","molecule","."),4243792). assertion_content_comment('oboGo_Number4Toluenecarboxylatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","4-toluenecarboxylate",",","4-methylbenzenecarboxylate",",","the","anion","of","carboxylic","acid","attached","to","a","methylbenzene","molecule","."),4243786). assertion_content_comment('oboGo_Number4Trimethylammoniobutyraldehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NAD","+","+","4-trimethylammoniobutanal","=","NADH","+","4-trimethylammoniobutanoate","."),4366049). assertion_content_comment('oboGo_Number510MethylenetetrahydrofolateDependentmethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","an","acceptor","molecule",";","dependent","on","the","presence","of","5",",","10-methylenetetrahydrofolate","."),4202182). assertion_content_comment('oboGo_Number510MethylenetetrahydrofolateDependenttrnam5u54methyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","5",",","10-methylenetetrahydrofolate","to","the","C5","atom","of","the","uridine","residue","at","position","54","in","a","tRNA","molecule","."),4308409). assertion_content_comment('oboGo_Number510Methylenetetrahydrofolateoxidation',"OBSOLETE.",4228353). assertion_content_comment('oboGo_Number5_34_Diacetoxybut_1_Ynyl_22_BithiopheneDeacetylaseActivity',s("Catalysis","of","the","reaction",":","5-","(","3",",","4-diacetoxybut-1-ynyl",")","-2",",","2","'","-bithiophene","+","H","(","2",")","O","=","5-","(","3-hydroxy-4-acetoxybut-1-ynyl",")","-2",",","2","'","-bithiophene","+","acetate","+","H","(","+",")"),4368723). assertion_content_comment('oboGo_Number5_3DNAHelicaseActivity',s("Catalysis","of","the","unwinding","of","the","DNA","helix","in","the","direction","5","'","to","3","'"),4317492). assertion_content_comment('oboGo_Number5_3DNARNAHelicaseActivity',s("Catalysis","of","the","unwinding","of","a","DNA/RNA","duplex","in","the","direction","5","'","to","3","'"),4341198). assertion_content_comment('oboGo_Number5_3ExodeoxyribonucleaseActivity',s("Catalysis","of","the","sequential","cleavage","of","mononucleotides","from","a","free","5","'","terminus","of","a","DNA","molecule","."),4183337). assertion_content_comment('oboGo_Number5_3ExonucleaseActivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","nucleic","acids","by","removing","nucleotide","residues","from","the","5","'","end","."),4183334). assertion_content_comment('oboGo_Number5_3ExoribonucleaseActivity',s("Catalysis","of","the","sequential","cleavage","of","mononucleotides","from","a","free","5","'","terminus","of","an","RNA","molecule","."),4204898). assertion_content_comment('oboGo_Number5_3RNAHelicaseActivity',s("Catalysis","of","the","unwinding","of","an","RNA","helix","in","the","direction","5","'","to","3","'"),4331751). assertion_content_comment('oboGo_Number56_Dihydroxy_3_Methyl_2_Oxo_1256_TetrahydroquinolineDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","5",",","6-dihydroxy-3-methyl-5",",","6-dihydroquinolin-2","(","1H",")","-one","+","NAD","(","+",")","=","5",",","6-dihydroxy-3-methyl-2-oxo-1",",","2-dihydroquinoline","+","H","(","+",")","+","NADH","."),4278509). assertion_content_comment('oboGo_Number56_Dihydroxy_3_Methyl_2_Oxo_12_DihydroquinolineDioxygenaseActivity',s("Catalysis","of","the","reaction",":","5",",","6-dihydroxy-3-methyl-2-oxo-1",",","2-dihydroquinoline","+","O2","=","3-methyl-5-hydroxy-6-","(","3-carboxy-3-oxopropenyl",")","-1H-2-pyridon","."),4278882). assertion_content_comment('oboGo_Number5Acylphosphoadenosinehydrolaseactivity',s("Catalysis","of","the","reaction",":","5","'","-acylphosphoadenosine","+","H2O","=","AMP","+","a","carboxylate","."),4370827). assertion_content_comment('oboGo_Number5alpha_Androstane_3beta17beta_DiolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","5alpha-androstane-3beta",",","17beta-diol","+","NADP","(","+",")","=","17beta-hydroxy-5alpha-androstan-3-one","+","H","(","+",")","+","NADPH","."),4363943). assertion_content_comment('oboGo_Number5AlphaHydroxysteroiddehydrataseactivity',s("Catalysis","of","the","reaction",":","5alpha-ergosta-7",",","22-diene-3beta",",","5-diol","=","ergosterol","+","H","(","2",")","O","."),4370838). assertion_content_comment('oboGo_Number5_Amino_4_ImidazoleCarboxylateLyaseActivity',s("Catalysis","of","the","reaction",":","5-aminoimidazole","+","CO2","=","5-amino-4-imidazole","carboxylate","."),4325743). assertion_content_comment('oboGo_Number5_Amino_6_5_PhosphoribitylaminoUracilPhosphataseActivity',s("Catalysis","of","the","reaction",":","5-amino-6-","(","5-phosphoribitylamino",")","-2",",","4","(","1H",",","3H",")","-pyrimidinedione","+","H2O","=","5-amino-6-ribitylamino-2",",","4","(","1H",",","3H",")","-pyrimidinedione","+","orthophosphate","."),4325755). assertion_content_comment('oboGo_Number5_Amino_6_5_PhosphoribosylaminoUracilReductaseActivity',s("Catalysis","of","the","reaction",":","5-amino-6-","(","5-phosphoribitylamino",")","uracil","+","NADP","(","+",")","=","5-amino-6-","(","5-phosphoribosylamino",")","uracil","+","H","(","+",")","+","NADPH","."),4251997). assertion_content_comment('oboGo_Number5Aminolevulinatesynthaseactivity',s("Catalysis","of","the","reaction",":","glycine","+","H","(","+",")","+","succinyl-CoA","=","5-aminolevulinate","+","CO","(","2",")","+","CoA","."),4189561). assertion_content_comment('oboGo_Number5Aminopentanamidaseactivity',s("Catalysis","of","the","reaction",":","5-aminopentanamide","+","H2O","=","5-aminopentanoate","+","NH3","."),4370850). assertion_content_comment('oboGo_Number5Aminosalicylatedioxygenaseactivity',s("Catalysis","of","the","reaction",":","5-aminosalicylate","+","O2","=","cis-4-amino-6-carboxy-2-oxo-hexa-3",",","5-dienoate","."),4352750). assertion_content_comment('oboGo_Number5Aminovaleratetransaminaseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","5-aminopentanoate","=","5-oxopentanoate","+","L-glutamate","."),4370862). assertion_content_comment('oboGo_Number5beta_Cholestane_3alpha7alpha_Diol12alpha_HydroxylaseActivity',s("Catalysis","of","the","reaction",":","5beta-cholestane-3alpha",",","7alpha-diol","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","5beta-cholestane-3alpha",",","7alpha",",","12alpha-triol","+","H","(","2",")","O","+","NADP","(","+",")"),4342055). assertion_content_comment('oboGo_Number5Carbamoylmethyluridinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","5-carbamoylmethyluridine","."),4181386). assertion_content_comment('oboGo_Number5Carboxyaminoimidazoleribonucleotidemutaseactivity',s("Catalysis","of","the","reaction",":","5-carboxyamino-1-","(","5-phospho-D-ribosyl",")","imidazole","=","5-amino-1-","(","5-phospho-D-ribosyl",")","imidazole-4-carboxylate","."),4361017). assertion_content_comment('oboGo_Number5Carboxyaminoimidazoleribonucleotidesynthaseactivity',s("Catalysis","of","the","reaction",":","5-amino-1-","(","5-phospho-D-ribosyl",")","imidazole","+","ATP","+","bicarbonate","=","5-carboxyamino-1-","(","5-phospho-D-ribosyl",")","imidazole","+","ADP","+","3","H","(","+",")","+","phosphate","."),4361106). assertion_content_comment('oboGo_Number5_Carboxymethyl_2_HydroxymuconateDelta_IsomeraseActivity',s("Catalysis","of","the","reaction",":","5-carboxymethyl-2-hydroxymuconate","=","5-carboxy-2-oxohept-3-enedioate","."),4251979). assertion_content_comment('oboGo_Number5_Carboxymethyl_2_Hydroxymuconic_SemialdehydeDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","5-carboxymethyl-2-hydroxymuconate","semialdehyde","+","H2O","+","NAD","+","=","5-carboxymethyl-2-hydroxymuconate","+","NADH","+","H","+"),4277209). assertion_content_comment('oboGo_Number5_Chloro_124_TrihydroxybenzeneDechlorinaseActivity',s("Catalysis","of","the","reaction",":","5-chloro-1",",","2",",","4-trihydroxybenzene","=","Cl-","+","H","+","+","2-hydroxy-1",",","4-benzoquinone","."),4273563). assertion_content_comment('oboGo_Number5_Chloro_2_HydroxymuconicSemialdehydeDehalogenaseActivity',s("Catalysis","of","the","reaction",":","5-chloro-2-hydroxymuconic","semialdehyde","+","H","+","+","2","e-","=","Cl-","+","2-hydroxymuconic","semialdehyde","."),4275302). assertion_content_comment('oboGo_Number5_Chloro_2_Oxopent_4_EnoateHydrataseActivity',s("Catalysis","of","the","reaction",":","5-chloro-2-oxopent-4-enoate","+","H2O","=","5-chloro-4-hydroxy-2-oxopentanate","."),4350196). assertion_content_comment('oboGo_Number5_Chloro_4_Hydroxy_2_OxopentanateAldolaseActivity',s("Catalysis","of","the","reaction",":","5-chloro-4-hydroxy-2-oxopentanate","=","pyruvate","+","chloroacetaldehyde","."),4350187). assertion_content_comment('oboGo_Number5_Dehydro_2_DeoxygluconokinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","5-dehydro-2-deoxy-D-gluconate","=","ADP","+","6-phospho-5-dehydro-2-deoxy-D-gluconate","."),4370550). assertion_content_comment('oboGo_Number5_Dehydro_2_DeoxyphosphogluconateAldolaseActivity',s("Catalysis","of","the","reaction",":","6-phospho-5-dehydro-2-deoxy-D-gluconate","=","3-oxopropanoate","+","glycerone","phosphate","."),4370115). assertion_content_comment('oboGo_Number5_Dehydro_4_DeoxyglucarateDehydrataseActivity',s("Catalysis","of","the","reaction",":","5-dehydro-4-deoxy-D-glucarate","+","H","(","+",")","=","2",",","5-dioxopentanoate","+","CO","(","2",")","+","H","(","2",")","O","."),4370214). assertion_content_comment('oboGo_Number5_Deoxyribose_5_PhosphateLyaseActivity',s("Catalysis","of","the","beta-elimination","of","the","5","'","deoxyribose-5-phosphate","at","an","abasic","site","in","DNA","where","a","DNA-","(","apurinic","or","apyrimidinic","site",")","lyase","has","already","cleaved","the","C-O-P","bond","3","'","to","the","apurinic","or","apyrimidinic","site","."),4284094). assertion_content_comment('oboGo_Number5ExoHydroxycamphordehydrogenaseactivity',s("Catalysis","of","the","reaction",":","5-exo-hydroxycamphor","+","NAD","+","=","NADH","+","H","+","+","2",",","5-diketocamphane","."),4281738). assertion_content_comment('oboGo_Number5Flapendonucleaseactivity',s("Catalysis","of","the","cleavage","of","a","5","'","flap","structure","in","DNA",",","but","not","other","DNA","structures",";","processes","the","5","'","ends","of","Okazaki","fragments","in","lagging","strand","DNA","synthesis","."),4267624). assertion_content_comment('oboGo_Number5FlapStructureddnabinding',s("Interacting","selectively","and","non-covalently","with","a","5","'","-flap","structure","in","DNA",".","A","DNA","flap","structure","is","one","in","which","a","single-stranded","5","'","-end","of","DNA","or","RNA","protrudes","from","a","double-stranded","DNA","molecule",".","5","'","-flap","structures","can","be","formed","during","DNA","repair","or","lagging","strand","synthesis",";","in","the","latter","case","RNA","flaps","form","from","lagging","strand","RNA","primers","."),4173170). assertion_content_comment('oboGo_Number5FormyltetrahydrofolatecycloLigaseactivity',s("Catalysis","of","the","reaction",":","5-formyltetrahydrofolate","+","ATP","=","5",",","10-methenyltetrahydrofolate","+","ADP","+","H","(","+",")","+","phosphate","."),4311943). assertion_content_comment('oboGo_Number5Formyltetrahydrofolatetransporteractivity',s("Enables","the","directed","movement","of","5-formyltetrahydrofolate",",","the","formylated","derivative","of","tetrahydrofolate",",","into",",","out","of",",","within",",","or","between","cells","."),4295295). assertion_content_comment('oboGo_Number5Formyltetrahydrofolatetransport',s("The","directed","movement","of","5-formyltetrahydrofolate",",","the","formylated","derivative","of","tetrahydrofolate",",","into",",","out","of",",","within",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4294218). assertion_content_comment('oboGo_Number5FormyluracildnanGlycosylaseactivity',s("Catalysis","of","the","removal","of","5-formyluracil","bases","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","oxidized","pyrimidine","and","the","deoxyribose","sugar","."),4360941). assertion_content_comment('oboGo_Number5_Guanidino_2_OxopentanoateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","5-guanidino-2-oxopentanoate","+","H","(","+",")","=","4-guanidinobutanal","+","CO","(","2",")"),4370347). assertion_content_comment('oboGo_Number5Ht1receptoractivity',s("A","serotonin","receptor","activity","that","acts","via","coupling","to","Gi/Go","to","initiate","a","change","in","cell","activity","."),4361428). assertion_content_comment('oboGo_Number5Ht2receptoractivity',s("A","serotonin","receptor","activity","that","acts","via","coupling","to","G11/q","to","initiate","a","change","in","cell","activity","."),4361394). assertion_content_comment('oboGo_Number5_Hydroxy_6E8Z11Z14Z_IcosatetraenoicAcidBinding',s("Interacting","selectively","and","non-covalently","with","5-hydroxy-6E",",","8Z",",","11Z",",","14Z-icosatetraenoic","acid",",","a","straight-chain","fatty","acid","with","twenty","carbon","atoms","and","four","double","bonds","."),4277647). assertion_content_comment('oboGo_Number5Hydroxyfuranocoumarin5OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","5-hydroxyfuranocoumarin","=","S-adenosyl-L-homocysteine","+","5-methoxyfuranocoumarin","."),4308561). assertion_content_comment('oboGo_Number5HydroxymethyluracildnanGlycosylaseactivity',s("Catalysis","of","the","removal","of","5-hydroxymethyluracil","bases","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","oxidized","pyrimidine","and","the","deoxyribose","sugar","."),4360931). assertion_content_comment('oboGo_Number5HydroxypentanoatecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","5-hydroxypentanoate","+","acetyl-CoA","=","5-hydroxy-pentanoyl-CoA","+","acetate","."),4370563). assertion_content_comment('oboGo_Number5_Hydroxypyrrole_2_CarboxylateTautomeraseActivity',s("Catalysis","of","the","reaction",":","5-hydroxypyrrole-2-carboxylate","=","5-oxo-4",",","5-dihydropyrrole-2-carboxylate","."),4348842). assertion_content_comment('oboGo_Number5Hydroxyvaleratedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","5-hydroxyvalerate","+","NAD","+","=","5-oxovalerate","+","NADH","."),4347504). assertion_content_comment('oboGo_Number5_Methyl_5678_Tetrahydromethanopterin_DependentMethyltransferaseActivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","an","acceptor","molecule",",","dependent","on","the","presence","of","5-methyl-5",",","6",",","7",",","8-tetrahydromethanopterin","."),4306541). assertion_content_comment('oboGo_Number5Methylcytosinebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","5-methylcytosine",",","a","methylated","base","of","DNA","."),4348041). assertion_content_comment('oboGo_Number5Methylcytosinecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","5-methylcytosine",",","a","methylated","base","of","DNA","."),4226347). assertion_content_comment('oboGo_Number5Methylcytosinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","5-methylcytosine",",","a","methylated","base","of","DNA","."),4226344). assertion_content_comment('oboGo_Number5_Methyldeoxycytidine_5_PhosphateKinaseActivity',s("Catalysis","of","the","reaction",":","2","'","-deoxy-5-methyl-5","'","-cytidylate","+","ATP","=","5-methyldeoxycytidine","diphosphate","+","ADP","+","H","(","+",")"),4368400). assertion_content_comment('oboGo_Number5MethyltetrahydrofolateDependentmethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","an","acceptor","molecule",";","dependent","on","the","presence","of","5-methyltetrahydrofolate","."),4251945). assertion_content_comment('oboGo_Number5MethyltetrahydropteroyltriglutamateHomocysteinesMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","5-methyltetrahydropteroyltri-L-glutamate","+","L-homocysteine","=","L-methionine","+","tetrahydropteroyltri-L-glutamate","."),4189601). assertion_content_comment('oboGo_Number5MethyltetrahydropteroyltriLGlutamateDependentmethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","an","acceptor","molecule",";","dependent","on","the","presence","of","5-methyltetrahydropteroyltri-L-glutamate","."),4189599). assertion_content_comment('oboGo_Number5MethylthiopentylDesulfoglucosinolatesulfotransferaseactivity',s("Catalysis","of","the","reaction",":","5-methylthiopentyl-desulfoglucosinolate","+","3","'","-phosphoadenosine","5","'","-phosphosulfate","=","5-methylthiopentyl-glucosinolate","+","adenosine","3","'",",","5","'","-bisphosphate","."),4182806). assertion_content_comment('oboGo_Number5MethylthiopropylglucosinolatesOxygenaseactivity',s("Catalysis","of","the","conversion","of","5-methylthiopropyl","glucosinolate","to","5-methylsulfinylpropyl","glucosinolate","."),4181497). assertion_content_comment('oboGo_Number5Nucleotidaseactivity',s("Catalysis","of","the","reaction",":","a","5","'","-ribonucleotide","+","H2O","=","a","ribonucleoside","+","phosphate","."),4256071). assertion_content_comment('oboGo_Number5_O_4_Coumaroyl_D_Quinate3_MonooxygenaseActivity',s("Catalysis","of","the","reaction",":","O2","+","NADPH","+","H","+","+","trans-5-O-","(","4-coumaroyl",")","-D-quinate","=","H2O","+","NADP","+","+","trans-5-O-caffeoyl-D-quinate","."),4365031). assertion_content_comment('oboGo_Number5_Oxo_45_Dihydropyrrole_2_CarboxylateAmidaseActivity',s("Catalysis","of","the","reaction",":","5-oxo-4",",","5-dihydropyrrole-2-carboxylate","+","2","H2O","=","2-oxoglutarate","+","NH3","."),4348833). assertion_content_comment('oboGo_Number5_Oxo_6E8Z11Z14Z_IcosatetraenoicAcidBinding',s("Interacting","selectively","and","non-covalently","with","5-oxo-6E",",","8Z",",","11Z",",","14Z-icosatetraenoic","acid",",","a","straight-chain","fatty","acid","with","twenty","carbon","atoms","and","four","double","bonds","."),4277637). assertion_content_comment('oboGo_Number5_Oxopent_3_Ene_125_TricarboxylateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","5-oxopent-3-ene-1",",","2",",","5-tricarboxylate","=","2-oxohept-3-enedioate","+","CO2","."),4274005). assertion_content_comment('oboGo_Number5OxoprolinaseatpHydrolyzingactivity',s("Catalysis","of","the","reaction",":","5-oxo-L-proline","+","ATP","+","2","H","(","2",")","O","=","L-glutamate","+","ADP","+","2","H","(","+",")","+","phosphate","."),4257817). assertion_content_comment('oboGo_Number5Oxovaleratedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","5-oxovalerate","+","NADP","+","+","H2O","=","glutarate","+","NADPH","+","H","+"),4221871). assertion_content_comment('oboGo_Number5Phosphoribose1Diphosphatebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","5-phosphoribose","1-diphosphate",",","also","known","as","5-phosphoribosyl-1-pyrophosphate","."),4225305). assertion_content_comment('oboGo_Number5Phosphoribose1Diphosphatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","5-phosphoribose","1-diphosphate",",","also","known","as","5-phosphoribosyl-1-pyrophosphate","."),4225301). assertion_content_comment('oboGo_Number5Phosphoribosyl1Pyrophosphatepyrophosphataseactivity',s("Catalysis","of","the","reaction",":","5-phospho-alpha-D-ribose","1-diphosphate","+","H2O","=","ribose","1",",","5","bisphosphate","+","phosphate","+","H","+"),4317456). assertion_content_comment('oboGo_Number5Phytaseactivity',s("Catalysis","of","the","reaction",":","H2O","+","myo-inositol","hexakisphosphate","=","phosphate","+","1L-myo-inositol","1",",","2",",","3",",","4",",","6-pentakisphosphate","."),4268638). assertion_content_comment('oboGo_Number5Pyridoxatedioxygenaseactivity',s("Catalysis","of","the","reaction",":","5-pyridoxate","+","NADPH","+","O","(","2",")","=","(","2Z",")","-2-","(","acetamidomethylene",")","-3-","(","hydroxymethyl",")","succinate","+","NADP","(","+",")"),4370525). assertion_content_comment('oboGo_Number5S_Hydroxyperoxy_6E8Z11Z14Z_IcosatetraenoicAcidBinding',s("Interacting","selectively","and","non-covalently","with","5","(","S",")","-hydroxyperoxy-6E",",","8Z",",","11Z",",","14Z-icosatetraenoic","acid",",","a","straight-chain","fatty","acid","with","twenty","carbon","atoms","and","four","double","bonds","."),4277617). assertion_content_comment('oboGo_Number5TyrosylDnaphosphodiesteraseactivity',s("Catalysis","of","the","hydrolysis","of","5","'","-phosphotyrosyl","groups","formed","as","covalent","intermediates","(","in","DNA","backbone","breakage",")","between","DNA","topoisomerase","II","and","DNA","."),4174383). assertion_content_comment('oboGo_Number5_Ureido_4_ImidazoleCarboxylateHydrolaseActivity',s("Catalysis","of","the","reaction",":","5-ureido-4-imidazole","carboxylate","+","H2O","=","5-amino-4-imidazole","carboxylate","+","NH3","+","CO2","."),4325713). assertion_content_comment('oboGo_Number5Valerolactonehydrolaseactivity',s("Catalysis","of","the","reaction",":","5-valerolactone","+","H2O","=","5-hydroxyvalerate","."),4221833). assertion_content_comment('oboGo_Number67Dihydropteridinereductaseactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","5",",","6",",","7",",","8-tetrahydropteridine","=","NADPH","+","H","+","+","6",",","7-dihydropteridine","."),4211409). assertion_content_comment('oboGo_Number67_Dimethyl_8_RibityllumazineSynthaseActivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydroxy-2-butanone-4-phosphate","+","5-amino-6-ribitylamino-2",",","4","(","1H",",","3H",")","-pyrimidinedione","=","6",",","7-dimethyl-8-ribityllumazine","+","phosphate","."),4363618). assertion_content_comment('oboGo_Number6Acetylglucosedeacetylaseactivity',s("Catalysis","of","the","reaction",":","6-acetyl-D-glucose","+","H","(","2",")","O","=","D-glucose","+","acetate","+","H","(","+",")"),4370537). assertion_content_comment('oboGo_Number6AlphaMaltosylglucosebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","6-alpha-maltosylglucose",",","also","known","as","isopanose","."),4285585). assertion_content_comment('oboGo_Number6AlphaMaltosylglucosecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","6-alpha-maltosylglucose",",","also","known","as","isopanose","."),4285536). assertion_content_comment('oboGo_Number6AlphaMaltosylglucosemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","6-alpha-maltosylglucose",",","also","known","as","isopanose","."),4285482). assertion_content_comment('oboGo_Number6AminohexanoateCyclicDimerhydrolaseactivity',s("Catalysis","of","the","reaction",":","1",",","8-diazacyclotetradecane-2",",","9-dione","+","H","(","2",")","O","=","N-","(","6-aminohexanoyl",")","-6-aminohexanoate","."),4234024). assertion_content_comment('oboGo_Number6AminohexanoateDimerhydrolaseactivity',s("Catalysis","of","the","reaction",":","N-","(","6-aminohexanoyl",")","-6-aminohexanoate","+","H2O","=","2","6-aminohexanoate","."),4234012). assertion_content_comment('oboGo_Number6Aminohexanoatetransaminaseactivity',s("Catalysis","of","the","reaction",":","6-aminohexanoate","+","alpha-ketoglutarate","=","glutamate","+","6-oxohexanoate","."),4275108). assertion_content_comment('oboGo_Number6BetaHydroxyhyoscyamineepoxidaseactivity',s("Catalysis","of","the","reaction",":","(","6S",")","-6-hydroxyhyoscyamine","+","2-oxoglutarate","+","O","(","2",")","=","CO","(","2",")","+","H","(","2",")","O","+","H","(","+",")","+","scopolamine","+","succinate","."),4370498). assertion_content_comment('oboGo_Number6_Carboxy_5678_TetrahydropterinSynthaseActivity',s("Catalysis","of","the","reaction",":","7",",","8-dihydroneopterin","triphosphate","+","H2O","=","6-carboxy-5",",","6",",","7",",","8-tetrahydropterin","+","acetaldehyde","+","PPPi","."),4175745). assertion_content_comment('oboGo_Number6CarboxyhexanoateCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","CoA","+","pimelate","=","AMP","+","diphosphate","+","H","(","+",")","+","pimelyl-CoA","."),4312277). assertion_content_comment('oboGo_Number6Deoxychalconesynthaseactivity',s("Catalysis","of","the","reaction",":","3","malonyl-CoA","+","4-coumaroyl-CoA","+","NADPH","+","H","+","=","4","CoA","+","isoliquiritigenin","+","3","CO2","+","NADP","+","+","H2O","."),4342840). assertion_content_comment('oboGo_Number6EndoHydroxycineoledehydrogenaseactivity',s("Catalysis","of","the","reaction",":","6-endo-hydroxycineole","+","NAD","(","+",")","=","6-oxocineole","+","H","(","+",")","+","NADH","."),4299725). assertion_content_comment('oboGo_Number6GFructosyltransferaseactivity',s("Catalysis","of","the","reaction",":","[","1-beta-D-fructofuranosyl-","(","2-","&","gt",";","1",")","-","]","m","+","1","alpha-D-glucopyranoside","+","[","1-beta-D-fructofuranosyl-","(","2-","&","gt",";","1",")","-","]","n","+","1","alpha-D-glucopyranoside","=","[","1-beta-D-fructofuranosyl-","(","2-","&","gt",";","1",")","-","]","m","alpha-D-glucopyranoside","+","[","1-beta-D-fructofuranosyl-","(","2-","&","gt",";","1",")","-","]","n","+","1","beta-D-fructofuranosyl-","(","2-","&","gt",";","6",")","-alpha-D-glucopyranoside","(","m","&","gt",";","0",";","n","&","gt",";","=","0",")"),4343273). assertion_content_comment('oboGo_Number6_Hydroxy_2_MercaptobenzothiazoleMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","6-hydroxy-2-mercaptobenzothiazole","+","1/2","O2","=","6",",","7-dihydroxy-2-mercaptobenzothiazole","."),4350638). assertion_content_comment('oboGo_Number6_Hydroxy_3_Methyl_2_Oxo_12_Dihydroquinoline6_MonooxygenaseActivity',s("Catalysis","of","the","reaction",":","6-hydroxy-3-methyl-2-oxo-1",",","2-dihydroquinoline","+","O2","+","2","H","+","+","2","e-","=","H2O","+","5",",","6-dihydroxy-3-methyl-2-oxo-1",",","2-dihydroquinoline","."),4276331). assertion_content_comment('oboGo_Number6_Hydroxy_3_SuccinoylpyridineHydrolaseActivity',s("Catalysis","of","the","reaction",":","6-hydroxy-3-succinoylpyridine","+","H2O","=","succinic","semialdehyde","+","2",",","5-dihydroxypyridine","."),4350394). assertion_content_comment('oboGo_Number6Hydroxycineolebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","6-hydroxycineole","(","6-hydroxy-1",",","8-epoxy-p-menthane",")",",","a","hydrocarbon","with","the","formula","C10H18O2","."),4353017). assertion_content_comment('oboGo_Number6Hydroxycineolecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","6-hydroxycineole","(","6-hydroxy-1",",","8-epoxy-p-menthane",")",",","a","hydrocarbon","with","the","formula","C10H18O2","."),4244152). assertion_content_comment('oboGo_Number6Hydroxycineolemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","6-hydroxycineole","(","6-hydroxy-1",",","8-epoxy-p-menthane",")",",","a","hydrocarbon","with","the","formula","C10H18O2","."),4244135). assertion_content_comment('oboGo_Number6_Hydroxycyclohex_1_Ene_1_Carboxyl_CoAHydrataseActivity',s("Catalysis","of","the","reaction",":","6-hydroxycyclohex-1-ene-1-carboxyl-CoA","+","H2O","=","2",",","6-dihydroxycyclohexane-1-carboxyl-CoA","."),4273913). assertion_content_comment('oboGo_Number6Hydroxyhexanoatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","6-hydroxyhexanoate","+","NAD","(","+",")","=","6-oxohexanoate","+","H","(","+",")","+","NADH","."),4277402). assertion_content_comment('oboGo_Number6HydroxymelleinoMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","6-hydroxymellein","+","S-adenosyl-L-methionine","=","6-methoxymellein","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4308507). assertion_content_comment('oboGo_Number6Hydroxynicotinate3Monooxygenaseactivity',s("Catalysis","of","the","oxidative","decarboxylation","of","6-hydroxynicotinate","to","2",",","5-dihydroxypyridine",",","dependent","on","O2",",","NADH","+","H","+","and","FAD","."),4325723). assertion_content_comment('oboGo_Number6Hydroxynicotinatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","6-hydroxynicotinate","+","H","(","2",")","O","+","O","(","2",")","=","2",",","6-dihydroxynicotinate","+","H","(","2",")","O","(","2",")"),4325924). assertion_content_comment('oboGo_Number6Hydroxynicotinatereductaseactivity',s("Catalysis","of","the","reaction",":","1",",","4",",","5",",","6-tetrahydro-6-oxonicotinate","+","oxidized","ferredoxin","=","6-hydroxynicotinate","+","reduced","ferredoxin","."),4370510). assertion_content_comment('oboGo_Number6Hydroxypseudooxynicotinedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","6-hydroxypseudooxynicotine","+","H2O","+","OH-","=","6-hydroxy-3-succinoylpyridine","+","4","H","+","+","4","e-","+","methylamine","."),4350214). assertion_content_comment('oboGo_Number6HydroxypseudoOxynicotinemonooxygenaseactivity',s("Catalysis","of","the","reaction",":","2","6-hydroxypseudooxynicotine","+","O2","=","2","2",",","6-dihydroxypseudooxynicotine","."),4276757). assertion_content_comment('oboGo_Number6Methylsalicylatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","6-methylsalicylate","+","H","(","+",")","=","3-cresol","+","CO","(","2",")"),4370599). assertion_content_comment('oboGo_Number6Methylsalicylicacidsynthaseactivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","3","H","(","+",")","+","3","malonyl-CoA","+","NADPH","=","6-methylsalicylate","+","3","CO","(","2",")","+","4","CoA","+","H","(","2",")","O","+","NADP","(","+",")"),4277720). assertion_content_comment('oboGo_Number6MethylthiopropylglucosinolatesOxygenaseactivity',s("Catalysis","of","the","conversion","of","6-methylthiopropyl","glucosinolate","to","6-methylsulfinylpropyl","glucosinolate","."),4181488). assertion_content_comment('oboGo_Number6OMethylnorlaudanosoline5OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","6-O-methylnorlaudanosoline","=","S-adenosyl-L-homocysteine","+","nororientaline","."),4309211). assertion_content_comment('oboGo_Number6_Oxo_2_Hydroxy_7_4_Chlorophenyl_388_Trichloroocta_2E4E7_TrienoateHydrolaseActivity',s("Catalysis","of","the","reaction",":","6-oxo-2-hydroxy-7-","(","4","'","-chlorophenyl",")","-3",",","8",",","8-trichloroocta-2Z",",","4Z",",","7-trienoate","+","H2O","=","2-","(","4","'","-chlorophenyl",")","-3",",","3-dichloropropenoate","+","cis-2-Hydroxy-3-chloropenta-2",",","4-dienone","+","H","+"),4274352). assertion_content_comment('oboGo_Number6_Oxo_2_Hydroxycyclohexane_1_Carboxyl_CoAHydrolaseActivity',s("Catalysis","of","the","reaction",":","6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA","+","H2O","=","3-hydroxypimeloyl-CoA","."),4275070). assertion_content_comment('oboGo_Number6Oxocineoledehydrogenaseactivity',s("Catalysis","of","the","reaction",":","6-oxocineole","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","1",",","6",",","6-trimethyl-2",",","7-dioxabicyclo","[","3.2.2","]","nonan-3-one","+","H","(","2",")","O","+","NADP","(","+",")"),4370612). assertion_content_comment('oboGo_Number6Oxohexanoatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","6-oxohexanoate","+","NADP","+","+","H2O","=","adipate","+","NADPH","+","H","+"),4277105). assertion_content_comment('oboGo_Number6PhosphoBetaGalactosidaseactivity',s("Catalysis","of","the","reaction",":","a","6-phospho-beta-D-galactoside","+","H2O","=","6-phospho-D-galactose","+","an","alcohol","."),4344624). assertion_content_comment('oboGo_Number6PhosphoBetaGlucosidaseactivity',s("Catalysis","of","the","reaction",":","6-phospho-beta-D-glucoside-","(","1",",","4",")","-D-glucose","+","H2O","=","D-glucose","6-phosphate","+","glucose","."),4251922). assertion_content_comment('oboGo_Number6_Phosphofructo_2_KinaseActivity',s("Catalysis","of","the","reaction",":","beta-D-fructose","6-phosphate","+","ATP","=","beta-D-fructose","2",",","6-bisphosphate","+","ADP","+","2","H","(","+",")"),4189663). assertion_content_comment('oboGo_Number6_Phosphofructo_2_KinaseFructose_26_Biphosphatase1Complex',s("A","homodimeric",",","bifunctional","enzyme","complex","which","catalyzes","the","synthesis","and","degradation","of","fructose","2",",","6-bisphosphate",",","and","is","required","for","both","glycolysis","and","gluconeogenesis","."),4325540). assertion_content_comment('oboGo_Number6Phosphofructokinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","D-fructose-6-phosphate","=","ADP","+","D-fructose","1",",","6-bisphosphate","."),4189641). assertion_content_comment('oboGo_Number6Phosphofructokinasecomplex',s("A","protein","complex","that","possesses","6-phosphofructokinase","activity",";","homodimeric",",","homooctameric",",","and","allosteric","homotetrameric","forms","are","known","."),4220774). assertion_content_comment('oboGo_Number6Phosphofructokinasereduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228278). assertion_content_comment('oboGo_Number6Phosphogluconolactonaseactivity',s("Catalysis","of","the","reaction",":","6-O-phosphono-D-glucono-1",",","5-lactone","+","H","(","2",")","O","=","6-phospho-D-gluconate","+","H","(","+",")"),4269753). assertion_content_comment('oboGo_Number6Pyruvoyltetrahydropterin2Reductaseactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","6-lactoyl-5",",","6",",","7",",","8-tetrahydropterin","=","NADPH","+","H","+","+","6-pyruvoyltetrahydropterin","."),4363997). assertion_content_comment('oboGo_Number6Pyruvoyltetrahydropterinsynthaseactivity',s("Catalysis","of","the","reaction",":","7",",","8-dihydroneopterin","3","'","-triphosphate","=","6-pyruvoyl-5",",","6",",","7",",","8-tetrahydropterin","+","H","(","+",")","+","triphosphate","."),4189679). assertion_content_comment('oboGo_Number78Dihydroxybenzoapyrenedioxygenaseactivity',s("Catalysis","of","the","reaction",":","benzo","(","a",")","pyrene-cis-7",",","8-dihydrodiol","+","O2","=","cis-4-","(","7-hydroxypyren-8-yl",")","-2-oxobut-3-enoate","."),4350484). assertion_content_comment('oboGo_Number78Dihydroxykynurenate88aDioxygenaseactivity',s("Catalysis","of","the","reaction",":","7",",","8-dihydroxykynurenate","+","O","(","2",")","=","5-","(","3-carboxylato-3-oxoprop-1-en-1-yl",")","-4",",","6-dihydroxypyridine-2-carboxylate","+","H","(","+",")"),4364680). assertion_content_comment('oboGo_Number7alpha_Hydroxycholest_4_En_3_One12alpha_HydroxylaseActivity',s("Catalysis","of","the","reaction",":","7alpha-hydroxycholest-4-en-3-one","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","7alpha",",","12alpha-dihydroxycholest-4-en-3-one","+","H","(","2",")","O","+","NADP","(","+",")"),4342027). assertion_content_comment('oboGo_Number7BetaHydroxysteroiddehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","a","7-beta-hydroxysteroid","=","NADPH","+","H","+","+","a","7-oxosteroid","."),4363917). assertion_content_comment('oboGo_Number7_Cyano_7_DeazaguanineTRNA_RibosyltransferaseActivity',s("Catalysis","of","the","reaction",":","tRNA","guanine","+","7-cyano-7-deazaguanine","=","tRNA","7-cyano-7-deazaguanine","+","guanine","."),4326633). assertion_content_comment('oboGo_Number7Dehydrocholesterolreductaseactivity',s("Catalysis","of","the","reaction",":","cholesterol","+","NADP","+","=","cholesta-5",",","7-dien-3-beta-ol","+","NADPH","+","H","+"),4370575). assertion_content_comment('oboGo_Number7Deoxyloganin7Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","7-deoxyloganin","+","NADPH","+","H","+","+","O2","=","loganin","+","NADP","+","+","H2O","."),4267968). assertion_content_comment('oboGo_Number7HydroxyChlorophyllideaoxygenaseactivity',s("Catalysis","of","the","reaction",":","7-hydroxychlorophyllide","a","+","NADPH","+","O2","+","H","+","=","chlorophyllide","b","+","NADP","+","+","2","H2O","."),4190957). assertion_content_comment('oboGo_Number7Methylguanosinebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","7-methylguanosine",",","a","modified","nucleoside","that","forms","a","cap","at","the","5","'","-terminus","of","eukaryotic","mRNA","."),4253090). assertion_content_comment('oboGo_Number7Methylguanosinecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","7-methylguanosine",",","a","modified","nucleoside","that","forms","a","cap","at","the","5","'","-terminus","of","eukaryotic","mRNA","."),4351865). assertion_content_comment('oboGo_Number7Methylguanosinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","7-methylguanosine",",","a","modified","nucleoside","that","forms","a","cap","at","the","5","'","-terminus","of","eukaryotic","mRNA","."),4253074). assertion_content_comment('oboGo_Number7MethylthioheptylDesulfoglucosinolatesulfotransferaseactivity',s("Catalysis","of","the","reaction",":","7-methylthioheptyl-desulfoglucosinolate","+","3","'","-phosphoadenosine","5","'","-phosphosulfate","=","7-methylthioheptyl-glucosinolate","+","adenosine","3","'",",","5","'","-bisphosphate","."),4182824). assertion_content_comment('oboGo_Number7MethylthiopropylglucosinolatesOxygenaseactivity',s("Catalysis","of","the","conversion","of","7-methylthiopropyl","glucosinolate","to","7-methylsulfinylpropyl","glucosinolate","."),4181479). assertion_content_comment('oboGo_Number8_Amino_7_OxononanoateSynthaseActivity',s("Catalysis","of","the","reaction",":","L-alanine","+","H","(","+",")","+","pimelyl-CoA","=","8-amino-7-oxononanoate","+","CO","(","2",")","+","CoA","."),4252050). assertion_content_comment('oboGo_Number8Hydroxyfuranocoumarin8OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","xanthotoxol","=","S-adenosyl-L-homocysteine","+","xanthotoxin",".","Xanthotoxol","is","also","known","as","8-hydroxyfuranocoumarin","and","xanthotoxin","as","8-methoxyfuranocoumarin","."),4308542). assertion_content_comment('oboGo_Number8Hydroxyquercitin8OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","3",",","3","'",",","4","'",",","5",",","7",",","8-hexahydroxyflavone","+","S-adenosyl-L-methionine","(","1","+",")","=","3",",","3","'",",","4","'",",","5",",","7-pentahydroxy-8-methoxyflavone","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4308669). assertion_content_comment('oboGo_Number8MethylthiooctylDesulfoglucosinolatesulfotransferaseactivity',s("Catalysis","of","the","reaction",":","8-methylthiooctyl-desulfoglucosinolate","+","3","'","-phosphoadenosine","5","'","-phosphosulfate","=","8-methylthiooctyl-glucosinolate","+","adenosine","3","'",",","5","'","-bisphosphate","."),4182734). assertion_content_comment('oboGo_Number8MethylthiopropylglucosinolatesOxygenaseactivity',s("Catalysis","of","the","conversion","of","8-methylthiopropyl","glucosinolate","to","8-methylsulfinylpropyl","glucosinolate","."),4181470). assertion_content_comment('oboGo_Number8_Oxo_78_DihydrodeoxyguanosineTriphosphatePyrophosphataseActivity',s("Catalysis","of","the","reaction",":","8-oxo-7",",","8-dihydrodeoxyguanosine-triphosphate","+","H2O","=","8-oxo-7",",","8-dihydrodeoxyguanosine","phosphate","+","diphosphate",".","8-oxo-7",",","8-dihydrodeoxyguanosine-triphosphate",",","or","8-oxo-dGTP",",","is","the","oxidised","form","of","the","free","guanine","nucleotide","and","can","act","as","a","potent","mutagenic","substrate","for","DNA","synthesis","causing","transversion","mutations",".","8-oxo-dGTPase","hydrolyses","8-oxo-dGTP","to","its","monophosphate","form","to","prevent","the","misincorporation","of","8-oxo-dGTP","into","cellular","DNA","."),4378628). assertion_content_comment('oboGo_Number8_Oxo_78_DihydroguanineDNAN_GlycosylaseActivity',s("Catalysis","of","the","removal","of","8-oxo-7",",","8-dihydroguanine","bases","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","oxidized","purine","and","the","deoxyribose","sugar","."),4360965). assertion_content_comment('oboGo_Number8_Oxo_78_DihydroguanosineTriphosphatePyrophosphataseActivity',s("Catalysis","of","the","reaction",":","8-oxo-7",",","8-dihydroguanosine","triphosphate","=","8-oxo-7",",","8-dihydroguanosine","phosphate","+","diphosphate",".","8-oxo-7",",","8-dihydroguanosine","triphosphate","(","8-oxo-GTP",")","is","the","oxidised","form","of","the","free","guanine","nucleotide","and","can","act","as","a","potent","mutagenic","substrate","for","transcription","."),4255695). assertion_content_comment('oboGo_Number8Oxocoformycinreductaseactivity',s("Catalysis","of","the","reaction",":","coformycin","+","NADP","(","+",")","=","8-oxocoformycin","+","2","H","(","+",")","+","NADPH","."),4370588). assertion_content_comment('oboGo_Number910910CarotenoidCleavingdioxygenaseactivity',s("Catalysis","of","the","oxidative","cleavage","of","carotenoids","at","the","(","9",",","10",")","and/or","(","9","'",",","10","'",")","double","bond","."),4333418). assertion_content_comment('oboGo_Number910Dihydroxybenzoapyrenedioxygenaseactivity',s("Catalysis","of","the","reaction",":","9",",","10-dihydroxybenzo","(","a",")","pyrene","+","O2","=","cis-4-","(","8-hydroxypyren-7-yl",")","-2-oxobut-3-enoate","."),4350502). assertion_content_comment('oboGo_Number9CisEpoxycarotenoiddioxygenaseactivity',s("Catalysis","of","the","reactions",":","a","9-cis-epoxycarotenoid","+","O2","=","2-cis",",","4-trans-xanthoxin","+","a","12","'","-apo-carotenal",";","9-cis-violaxanthin","+","O2","=","2-cis",",","4-trans-xanthoxin","+","(","3S",",","5R",",","6S",")","-5",",","6-epoxy-3-hydroxy-5",",","6-dihydro-12","'","-apo-beta-caroten-12","'","-al",";","and","9","'","-cis-neoxanthin","+","O2","=","2-cis",",","4-trans-xanthoxin","+","(","3S",",","5R",",","6R",")","-5",",","6-dihydroxy-6",",","7-didehydro-5",",","6-dihydro-12","'","-apo-beta-caroten-12","'","-al","."),4299369). assertion_content_comment('oboGo_Number9CisRetinoicacidbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","9-cis-retinoic","acid",",","a","metabolically","active","vitamin","A","derivative","."),4315989). assertion_content_comment('oboGo_Number9CisRetinoicacidmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","9-cis-retinoic","acid",",","a","metabolically","active","vitamin","A","derivative","."),4315961). assertion_content_comment('oboGo_Number9_Fluorenone_34_DioxygenaseActivity',s("Catalysis","of","the","reaction",":","9-fluorenone","+","O2","+","2","H","+","+","2","e-","=","1-hydro-1",",","1a-dihydroxy-9-fluorenone","."),4349541). assertion_content_comment('oboGo_Number9Fluorenonedioxygenaseactivity',s("Catalysis","of","the","reaction",":","9-fluorenone","+","2","NADPH","+","O2","=","2","NADP","+","+","3",",","4-dihydroxy-3",",","4-dihydro-9-fluorenone","."),4276841). assertion_content_comment('oboGo_Number9Phenanthrolglycosyltransferaseactivity',s("Catalysis","of","the","reaction",":","9-phenanthrol","+","glucose","=","9-phenanthryl-beta-D-glucopyranoside","+","H2O","."),4275237). assertion_content_comment('oboGo_Number9Phenanthrolsulfotransferaseactivity',s("Catalysis","of","the","reaction",":","9-phenanthrol","+","X-SO3","(","-",")","=","HX","+","9-phenanthrylsulfate","."),4275176). assertion_content_comment('oboGo_Number9PhenanthroludpGlucuronosyltransferaseactivity',s("Catalysis","of","the","reaction",":","9-phenanthrol","+","UDP-glucuronate","=","9-phenanthryl-beta-D-glucuronide","+","UDP","."),4275246). assertion_content_comment('oboGo_Nup107_160Complex',s("A","subcomplex","of","the","nuclear","pore","complex","(","NPC",")","involved","in","mRNA","export","and","NPC","assembly",".","Contains","conserved","nucleoporins","and","other","proteins",";","for","example",",","the","Saccharomyces","complex","contains","Nup84p",",","Nup85p",",","Nup120p",",","Nup145p-C",",","Seh1p",",","Sec13p",",","and","Nup133p","."),4062956). assertion_content_comment('oboGo_O3_N_Acetylglucosamine_1_Phosphoryl_L_SerineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","O3-","(","N-acetylglucosamine-1-phosphoryl",")","-L-serine",".","The","recovery","of","O-phosphorylserine","from","acid","hydrolysates","suggests","N-acetylglucosamine-1-phosphate","residues","are","esterified","to","peptidyl","serines","through","phosphoester","bonds","."),4281852). assertion_content_comment('oboGo_O3_Phosphoglycosyl_D_Mannose_1_Phosphoryl_L_SerineBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","O3-","(","phosphoglycosyl-D-mannose-1-phosphoryl",")","-L-serine",".","The","polypeptide","backbones","of","glycoproteins","and","mucin-like","proteoglycans","are","extensively","modified","with","a","complex","array","of","phosphoglycan","chains","that","are","linked","to","Ser/Thr-rich","domains","via","a","common","Man-alpha1-PO4-Ser","linkage","."),4281877). assertion_content_comment('oboGo_O6AlkylguanineDnabinding',s("Interacting","selectively","and","non-covalently","with","O6-alkylguanine","adducts","in","DNA","."),4329325). assertion_content_comment('oboGo_OAcetylhomoserineaminocarboxypropyltransferaseactivity',s("Catalysis","of","the","reaction",":","O-acetyl-L-homoserine","+","methanethiol","=","L-methionine","+","acetate","."),4185167). assertion_content_comment('oboGo_OAcetylhomoserinesulfhydrylaseactivity',s("Catalysis","of","the","reaction",":","O-acetyl-L-homoserine","+","hydrogen","sulfide","=","homocysteine","+","acetate","."),4279189). assertion_content_comment('oboGo_OAcetyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","acetyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4206300). assertion_content_comment('oboGo_OAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","acyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4182479). assertion_content_comment('oboGo_OAminophenoloxidaseactivity',s("Catalysis","of","the","reaction",":","2","2-aminophenol","+","3","O2","=","2","isophenoxazine","+","6","H2O","."),4271396). assertion_content_comment('oboGo_OButanoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","butyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4355321). assertion_content_comment('oboGo_ODecanoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","decyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4355230). assertion_content_comment('oboGo_ODemethylpuromycinoMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","O-demethylpuromycin","=","S-adenosyl-L-homocysteine","+","puromycin","."),4308838). assertion_content_comment('oboGo_ODihydroxycoumarin7OGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","7",",","8-dihydroxycoumarin","+","UDP-D-glucose","=","daphnin","+","H","(","+",")","+","UDP","."),4366603). assertion_content_comment('oboGo_OdontogenesisOfDentineContainingtooth',s("The","process","whose","specific","outcome","is","the","progression","of","a","dentine-containing","tooth","over","time",",","from","its","formation","to","the","mature","structure",".","A","dentine-containing","tooth","is","a","hard",",","bony","organ","borne","on","the","jaw","or","other","bone","of","a","vertebrate",",","and","are","composed","mainly","of","dentine",",","a","dense","calcified","substance",",","covered","by","a","layer","of","enamel","."),4078513). assertion_content_comment('oboGo_OFucosylpeptide3BetaNAcetylglucosaminyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","beta-D-GlcNAc","residue","from","UDP-D-GlcNAc","to","the","fucose","residue","of","a","fucosylated","protein","acceptor","."),4343149). assertion_content_comment('oboGo_OGlycanprocessingcore1',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","the","core","1","O-glycan","structure",",","Gal-beta-1-","&","gt",";","3-GalNAc","."),4303554). assertion_content_comment('oboGo_OGlycanprocessingcore2',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","the","core","2","O-glycan","structure",",","GlcNAc-beta-1-","&","gt",";","6","(","Gal-beta-1-","&","gt",";","3",")","-GalNAc","."),4303647). assertion_content_comment('oboGo_OGlycanprocessingcore3',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","the","core","3","O-glycan","structure",",","GlcNAc-beta-1-","&","gt",";","3-GalNAc","."),4303637). assertion_content_comment('oboGo_OGlycanprocessingcore4',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","the","core","4","O-glycan","structure",",","GlcNAc-beta-1-","&","gt",";","6","(","GlcNAc-beta-1-","&","gt",";","3",")","-GalNAc","."),4303657). assertion_content_comment('oboGo_OGlycanprocessingcore5',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","the","core","5","O-glycan","structure",",","GalNAc-alpha-1-","&","gt",";","3-GalNAc","."),4319369). assertion_content_comment('oboGo_OGlycanprocessingcore6',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","the","core","6","O-glycan","structure",",","GlcNAc-beta-1-","&","gt",";","6-GalNAc","."),4319379). assertion_content_comment('oboGo_OGlycanprocessingcore7',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","the","core","7","O-glycan","structure",",","GalNAc-alpha-1-","&","gt",";","6-GalNAc","."),4319389). assertion_content_comment('oboGo_OGlycanprocessingcore8',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","the","core","8","O-glycan","structure",",","Gal-alpha-1-","&","gt",";","3-GalNAc","."),4319399). assertion_content_comment('oboGo_OGlycanprocessing',s("The","stepwise","addition","of","sugar","residues","to","the","initially","added","O-linked","sugar","(","usually","GalNAc",")","to","form","a","core","O-glycan","structure","."),4303552). assertion_content_comment('oboGo_OGlycosidebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","O-glycosides",",","any","compound","in","which","a","glycosyl","group","has","been","substituted","into","a","hydroxyl","group","."),4303121). assertion_content_comment('oboGo_OGlycosidecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","O-glycosides",",","any","compound","in","which","a","glycosyl","group","has","been","substituted","into","a","hydroxyl","group","."),4303107). assertion_content_comment('oboGo_OGlycosidemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","O-glycosides",",","any","compound","in","which","a","glycosyl","group","has","been","substituted","into","a","hydroxyl","group","."),4303095). assertion_content_comment('oboGo_OHexanoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","hexyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4355263). assertion_content_comment('oboGo_OHydroxycinnamoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","hydroxycinnamoyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4275821). assertion_content_comment('oboGo_OHydroxylaminobenzoatemutaseactivity',s("Catalysis","of","the","reaction",":","o-hydroxylaminobenzoate","=","3-hydroxyanthranilate","."),4348723). assertion_content_comment('oboGo_OleoylAcylCarrierProteinhydrolaseactivity',s("Catalysis","of","the","reaction",":","oleoyl-","[","acyl-carrier","protein","]","+","H2O","=","[","acyl-carrier","protein","]","+","oleate","."),4208678). assertion_content_comment('oboGo_Oligo_16_GlucosidaseActivity',s("Catalysis","of","the","hydrolysis","of","1",",","6-alpha-D-glucosidic","linkages","in","some","oligosaccharides","produced","from","starch","and","glycogen","by","alpha-amylase",",","and","in","isomaltose","."),4204420). assertion_content_comment('oboGo_OligopeptideTransportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","oligopeptide","(","out",")","=","ADP","+","phosphate","+","oligopeptide","(","in",")"),4291610). assertion_content_comment('oboGo_Oligosaccharide4AlphaDGlucosyltransferaseactivity',s("Catalysis","of","the","transfer","of","the","non-reducing","terminal","alpha-D-glucose","residue","from","a","1",",","4-alpha-D-glucan","to","the","4-position","of","an","alpha-D-glucan",",","thus","bringing","about","the","hydrolysis","of","oligosaccharides","."),4343174). assertion_content_comment('oboGo_OligosaccharideDiphosphodolicholdiphosphataseactivity',s("Catalysis","of","the","reaction",":","H2O","+","oligosaccharide-diphosphodolichol","=","dolichol-phosphate","+","oligosaccharide","phosphate","."),4370265). assertion_content_comment('oboGo_OligosaccharideLipidintermediateassembly',s("The","cellular","metabolic","process","in","which","an","intermediate","molecule","of","dolichol-P-man","or","dolicol-P-Glc","is","assembled","to","be","used","in","N-linked","glycosylation","."),4010135). assertion_content_comment('oboGo_OligosaccharideReducingEndxylanaseactivity',s("Catalysis","of","the","hydrolysis","of","1",",","4-beta-D-xylose","residues","from","the","reducing","end","of","oligosaccharides","."),4344467). assertion_content_comment('oboGo_OligosaccharideTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","oligosaccharide","(","out",")","=","ADP","+","phosphate","+","oligosaccharide","(","in",")"),4291580). assertion_content_comment('oboGo_OligoxyloglucanBetaGlycosidaseactivity',s("Catalysis","of","the","hydrolysis","of","1",",","4-beta-D-glucosidic","links","in","oligoxyloglucans","so","as","to","remove","successive","isoprimeverose","(","i.e",".","alpha-xylo-1",",","6-beta-D-glucosyl-",")","residues","from","the","non-reducing","chain","ends","."),4344844). assertion_content_comment('oboGo_OligoxyloglucanReducingEndSpecificcellobiohydrolaseactivity',s("Catalysis","of","the","hydrolysis","of","cellobiose","from","the","reducing","end","of","xyloglucans","consisting","of","a","beta-1",",","4-linked","glucan","carrying","alpha-D-xylosyl","groups","on","O-6","of","the","glucose","residues",".","To","be","a","substrate",",","the","first","residue","must","be","unsubstituted",",","the","second","residue","may","bear","a","xylosyl","group",",","whether","further","glycosylated","or","not",",","and","the","third","residue",",","which","becomes","the","new","terminus","by","the","action","of","the","enzyme",",","is","preferably","xylosylated",",","but","this","xylose","residue","must","not","be","further","substituted","."),4344432). assertion_content_comment('oboGo_OLinoleoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","linoleoyl","(","(","9Z",",","12Z",")","-octadeca-9",",","12-dienoyl",")","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4331772). assertion_content_comment('oboGo_OMalonyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","malonyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4275811). assertion_content_comment('oboGo_Omega_3FattyAcidDesaturaseActivity',s("Catalysis","of","the","introduction","of","an","omega-3","double","bond","into","the","fatty","acid","hydrocarbon","chain","."),4262015). assertion_content_comment('oboGo_Omega_6FattyAcidDesaturaseActivity',s("Catalysis","of","the","introduction","of","an","omega-6","double","bond","into","the","fatty","acid","hydrocarbon","chain","."),4299798). assertion_content_comment('oboGo_OmegaAmidaseactivity',s("Catalysis","of","the","reaction",":","a","monoamide","of","a","dicarboxylic","acid","+","H2O","=","a","dicarboxylate","+","NH3","."),4271347). assertion_content_comment('oboGo_OmegaHydroxydecanoatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","10-hydroxydecanoate","+","NAD","(","+",")","=","10-oxodecanoate","+","H","(","+",")","+","NADH","."),4271359). assertion_content_comment('oboGo_OMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","the","oxygen","atom","of","an","acceptor","molecule","."),4175356). assertion_content_comment('oboGo_OncogeneInducedsenescence',s("A","cellular","senescence","process","associated","with","the","dismantling","of","a","cell","as","a","response","to","oncogenic","stress",",","such","as","the","activation","of","the","Ras","oncogenic","family","."),4155140). assertion_content_comment('oboGo_OncostatinMreceptoractivity',s("Combining","with","oncostatin-M","to","initiate","a","change","in","cell","activity","."),4198458). assertion_content_comment('oboGo_OncostatinMreceptorbinding',s("Interacting","selectively","and","non-covalently","with","the","oncostatin-M","receptor","."),4214400). assertion_content_comment('oboGo_OncostatinMreceptorcomplex',s("A","heterodimeric","receptor","for","the","cytokine","oncostatin-M","(","OSM",")","In","humans","the","receptor","complex","is","made","up","of","the","gene","products","gp130","and","OSMR-beta","."),4008257). assertion_content_comment('oboGo_OneCarboncompoundtransport',s("The","directed","movement","of","one-carbon","compounds","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4245436). assertion_content_comment('oboGo_OneCarbonmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","the","transfer","of","one-carbon","units","in","various","oxidation","states","."),3975503). assertion_content_comment('oboGo_OOctanoyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","octanoyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4254019). assertion_content_comment('oboGo_OocyteGrowthInGermariumDerivedeggchamber',s("The","increase","in","volume","of","an","oocyte","during","the","growth","phase","of","the","egg","chamber",",","once","the","egg","chamber","has","left","the","germarium",".","An","example","of","this","process","is","found","in","Drosophila","melanogaster","."),4052182). assertion_content_comment('oboGo_OocyteLocalizationInvolvedInGermariumDerivedeggchamberformation',s("Directed","movement","of","the","oocyte",",","following","its","specification",",","from","its","original","central","position","in","the","cyst","to","a","posterior","position","relative","to","the","nurse","cells","of","the","egg","chamber",",","and","its","maintenance","in","this","posterior","location",".","This","is","the","first","sign","of","anterior-posterior","asymmetry","in","the","developing","egg","chamber","."),4051975). assertion_content_comment('oboGo_OPalmitoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","palmitoyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4212199). assertion_content_comment('oboGo_OpenFormFourWayjunctiondnabinding',s("Interacting","selectively","and","non-covalently","with","DNA","containing","the","open","form","of","a","four-way","junction",",","also","known","as","a","Holliday","junction",",","a","structure","where","two","DNA","double","strands","are","held","together","by","reciprocal","exchange","of","two","of","the","four","strands",",","one","strand","each","from","the","two","original","helices",".","The","open","form","of","a","four-way","junction","can","be","diagrammed","without","any","of","the","strands","crossing","over","."),4362758). assertion_content_comment('oboGo_OPhosphoLSerine_2Oxoglutarateaminotransferaseactivity',s("Catalysis","of","the","reaction",":","O-phospho-L-serine","+","2-oxoglutarate","=","3-phosphonooxypyruvate","+","L-glutamate","."),4203431). assertion_content_comment('oboGo_OPhosphoserinesulfhydrylaseactivity',s("Catalysis","of","the","reaction",":","O-phospho-L-serine","+","hydrogen","sulfide","=","L-cysteine","+","phosphate","."),4343862). assertion_content_comment('oboGo_OplophorusLuciferin2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","Oplophorus","luciferin","+","O2","=","oxidized","Oplophorus","luciferin","+","CO2","+","hnu","."),4342641). assertion_content_comment('oboGo_OpticCupFormationInvolvedInCameraTypeeyedevelopment',s("The","developmental","process","pertaining","to","the","initial","formation","of","the","optic","cup",",","a","two-walled","vesicle","formed","from","the","optic","vesicle","."),4004567). assertion_content_comment('oboGo_OpticCupMorphogenesisInvolvedInCameraTypeeyedevelopment',s("The","invagination","of","the","optic","vesicle","to","form","two-walled","indentations",",","the","optic","cups",",","that","will","go","on","to","form","the","retina",".","This","process","begins","with","the","optic","vesicle","becoming","a","two-walled","structure","and","its","subsequent","shape","changes",".","It","does","not","include","the","fate","commitment","of","cells","to","become","the","pigmented","retina","and","the","neural","retina",".","An","example","of","this","process","is","found","in","Mus","musculus","."),3990063). assertion_content_comment('oboGo_OpticPlacodeFormationInvolvedInCameraTypeeyeformation',s("Establishment","and","formation","of","the","optic","placode",",","paired","ectodermal","placodes","that","become","invaginated","to","form","the","embryonic","lens","vesicles","."),4098809). assertion_content_comment('oboGo_OPyrocatechuatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-dihydroxybenzoate","+","H","(","+",")","=","catechol","+","CO","(","2",")"),4271371). assertion_content_comment('oboGo_Orcinol2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADH","+","O","(","2",")","+","orcinol","=","2",",","3",",","5-trihydroxytoluene","+","H","(","2",")","O","+","NAD","(","+",")"),4276556). assertion_content_comment('oboGo_OrganellarVoltageGatedchloridechannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","chloride","ion","by","a","voltage-gated","channel",".","The","membrane","is","an","organellar","membrane","."),4295198). assertion_content_comment('oboGo_OrganelleEnclosinglipidmonolayer',s("A","lipid","monolayer","that","surrounds","and","encloses","an","organelle","."),4065764). assertion_content_comment('oboGo_OrganicAcidTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","organic","acid","(","out/in",")","=","ADP","+","phosphate","+","organic","acid","(","in/out",")"),4337792). assertion_content_comment('oboGo_OrnithineAcylacylcarrierproteinnAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","3R",")","-3-hydroxyacyl-","[","acyl-carrier","protein","]","+","L-ornithine","=","lyso-ornithine","lipid","+","[","acyl-carrier","protein","]"),4327547). assertion_content_comment('oboGo_OrnithineN5Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","L-ornithine","+","O2","+","H","+","=","N5-hydroxy-L-ornithine","+","H2O","."),4319016). assertion_content_comment('oboGo_OrnithineNBenzoyltransferaseactivity',s("Catalysis","of","the","reaction",":","L-ornithine","+","2","benzoyl-CoA","=","N","(","2",")",",","N","(","5",")","-dibenzoyl-L-ornithine","+","2","CoA","+","2","H","(","+",")"),4271288). assertion_content_comment('oboGo_OrnithineOxoAcidtransaminaseactivity',s("Catalysis","of","the","reaction",":","L-ornithine","+","a","2-oxo","acid","=","L-glutamate","5-semialdehyde","+","an","L-amino","acid","."),4204234). assertion_content_comment('oboGo_Orotidine_5_PhosphateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","orotidine","5","'","-phosphate","=","CO","(","2",")","+","UMP","."),4203905). assertion_content_comment('oboGo_OrsellinateDepsidehydrolaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","orsellinate","depside","=","2","o-orsellinate","+","H","(","+",")"),4271197). assertion_content_comment('oboGo_OrthoTrichlorophenolreductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","2",",","4",",","6-trichlorophenol","+","2","H","+","+","2","e-","=","2",",","4-dichlorophenol","+","HCl","."),4275535). assertion_content_comment('oboGo_OSialoglycoproteincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","O-sialoglycoproteins",",","glycoproteins","which","contain","sialic","acid","as","one","of","their","carbohydrates",".","They","are","often","found","on","or","in","the","cell","or","tissue","membranes","and","participate","in","a","variety","of","biological","activities","."),4300216). assertion_content_comment('oboGo_OSialoglycoproteinendopeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","O-sialoglycoproteins",";","cleaves","the","-Arg31-Asp32-","bond","in","glycophorin","A",".","Does","not","cleave","unglycosylated","proteins",",","desialylated","glycoproteins","or","glycoproteins","that","are","only","N-glycosylated","."),4253971). assertion_content_comment('oboGo_OSinapoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","sinapoyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4301297). assertion_content_comment('oboGo_OsmosensorySignalingPathwayViaTwoComponentsystem',s("A","series","of","molecular","signals","generated","in","response","to","osmotic","change",",","as","mediated","through","a","two-component","(","phosphorelay",")","system","."),4235457). assertion_content_comment('oboGo_OSuccinylbenzoateCoaligaseactivity',s("Catalysis","of","the","reaction",":","2-succinylbenzoate","+","ATP","+","CoA","=","2-succinylbenzoyl-CoA","+","AMP","+","diphosphate"),4251488). assertion_content_comment('oboGo_OSuccinylbenzoatesynthaseactivity',s("Catalysis","of","the","reaction",":","2-succinylbenzoate","+","H2O","=","2-succinyl-6-hydroxy-2",",","4-cyclohexadiene-1-carboxylate","."),4326050). assertion_content_comment('oboGo_OSuccinyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","succinyl","group","to","an","oxygen","atom","on","the","acceptor","molecule","."),4249501). assertion_content_comment('oboGo_OtherCarbonCarbonlyaseactivity',s("OBSOLETE",".","A","grouping","term","for","carbon-carbon","lyases","that","cannot","be","more","accurately","categorized","."),4301645). assertion_content_comment('oboGo_OtherCarbonNitrogenligaseactivity',s("OBSOLETE",".","A","grouping","term","for","carbon-nitrogen","ligases","that","cannot","be","more","accurately","categorized","."),4301854). assertion_content_comment('oboGo_OtherCarbonNitrogenlyaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","a","carbon-nitrogen","bond",".","Enzymes","with","this","activity","are","'","miscellaneous","'","carbon-nitrogen","lyases","that","cannot","be","grouped","into","one","of","the","specific","subclasses","of","the","carbon-nitrogen","lyases","."),4301713). assertion_content_comment('oboGo_OtherCarbonOxygenlyaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","a","carbon-oxygen","bond",".","Enzymes","with","this","activity","are","'","miscellaneous","'","carbon-oxygen","lyases","that","cannot","be","grouped","into","one","of","the","specific","subclasses","of","the","carbon-oxygen","lyases","."),4301688). assertion_content_comment('oboGo_OuterMembraneBoundedperiplasmicspace',s("The","region","between","the","inner","(","cytoplasmic","or","plasma",")","membrane","and","outer","membrane","of","organisms","with","two","membranes","such","as","Gram","negative","bacteria",".","These","periplasmic","spaces","are","relatively","thick","and","contain","a","thin","cell","wall","."),4048864). assertion_content_comment('oboGo_OvarianFollicleCellCelladhesion',s("The","attachment","of","a","somatic","follicle","cell","to","another","somatic","follicle","cell","or","to","its","substratum",",","the","germline","cells",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4018802). assertion_content_comment('oboGo_OvuleProducingovarydevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","ovary","that","produces","an","ovule","over","time",",","from","its","formation","to","the","mature","structure",".","The","ovary","is","the","enlarged","basal","portion","of","a","carpel","and","matures","into","a","fruit",".","An","ovule","is","the","multicellular","structure","that","gives","rise","to","and","contains","the","female","reproductive","cells",",","and","develops","into","a","seed","."),4028913). assertion_content_comment('oboGo_OvumProducingovarydevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","an","ovary","that","produces","an","ovum","over","time",",","from","its","formation","to","the","mature","structure","."),3981102). assertion_content_comment('oboGo_OvumProducingovarymorphogenesis',s("The","process","in","which","an","ovum-producing","ovary","is","generated","and","organized","."),4113343). assertion_content_comment('oboGo_OxalateCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","CoA","+","oxalate","=","AMP","+","diphosphate","+","H","(","+",")","+","oxalyl-CoA","."),4264428). assertion_content_comment('oboGo_OxalateCoATransferaseactivity',s("Catalysis","of","the","reaction",":","oxalate","+","succinyl-CoA","=","oxalyl-CoA","+","succinate","."),4271207). assertion_content_comment('oboGo_OxalylCoadecarboxylaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","oxalyl-CoA","=","CO","(","2",")","+","formyl-CoA","."),4247506). assertion_content_comment('oboGo_OxidationDependentproteincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds",",","initiated","by","the","oxidation","of","one","or","more","amino","acid","residues","in","the","protein","."),4175704). assertion_content_comment('oboGo_OxidationReductionprocess',s("A","metabolic","process","that","results","in","the","removal","or","addition","of","one","or","more","electrons","to","or","from","a","substance",",","with","or","without","the","concomitant","removal","or","addition","of","a","proton","or","protons","."),4008782). assertion_content_comment('oboGo_OxidativeSingleStrandeddnademethylation',s("Removal","of","the","methyl","group","from","one","or","more","nucleotides","within","a","single-stranded","DNA","molecule","involving","the","oxidation","(","i.e",".","electron","loss",")","of","one","or","more","atoms","."),4378587). assertion_content_comment('oboGo_OxidativeSingleStrandedrnademethylation',s("Removal","of","the","methyl","group","from","one","or","more","nucleotides","within","a","single-stranded","RNA","molecule","involving","the","oxidation","(","i.e",".","electron","loss",")","of","one","or","more","atoms","."),4378567). assertion_content_comment('oboGo_OxidativeStressInducedprematuresenescence',s("A","cellular","senescence","process","associated","with","the","dismantling","of","a","cell","as","a","response","to","oxidative","stress",",","e.g",".","high","levels","of","reactive","oxygen","species",",","such","as","superoxide","anions",",","hydrogen","peroxide",",","and","hydroxyl","radicals","."),4155131). assertion_content_comment('oboGo_OxidizedBaseLesionDNANGlycosylaseactivity',s("Catalysis","of","the","removal","of","oxidized","bases","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","target","damaged","DNA","base","and","the","deoxyribose","sugar",".","The","reaction","releases","a","free","base","and","leaves","an","apurinic/apyrimidinic","(","AP",")","site","."),4249865). assertion_content_comment('oboGo_OxidizedLowDensitylipoproteincatabolicprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","oxidized","low-density","lipoproteins","."),4300458). assertion_content_comment('oboGo_OxidizedPurineBaseLesionDNANGlycosylaseactivity',s("Catalysis","of","the","removal","of","oxidized","purine","bases","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","oxidized","purine","and","the","deoxyribose","sugar",".","The","reaction","involves","the","formation","of","a","covalent","enzyme-substrate","intermediate",".","Release","of","the","enzyme","and","free","base","by","a","beta-elimination","or","a","beta",",","gamma-elimination","mechanism","results","in","the","cleavage","of","the","DNA","backbone","3","'","of","the","apurinic","(","AP",")","site","."),4254906). assertion_content_comment('oboGo_OxidizedPyrimidineBaseLesionDNANGlycosylaseactivity',s("Catalysis","of","the","removal","oxidized","pyrimidine","bases","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","oxidized","pyrimidine","and","the","deoxyribose","sugar",".","The","reaction","involves","formation","of","a","covalent","enzyme-pyrimidine","base","intermediate",".","Release","of","the","enzyme","and","free","base","by","a","beta-elimination","or","a","beta",",","gamma-elimination","mechanism","results","in","the","cleavage","of","the","DNA","backbone","3","'","of","the","apyrimidinic","(","AP",")","site","."),4249868). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnASulfurGroupOfDonorsIronSulfurproteinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","sulfur-containing","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","iron-sulfur","protein","."),4265456). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnCHOhgroupofdonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-OH","group","act","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4157655). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnCHOrCH2GroupsWithAnIronSulfurproteinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","iron-sulfur","protein","."),4186650). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnHydrogenAsDonorIronSulfurproteinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","acts","as","an","electron","donor","and","reduces","an","iron-sulfur","protein","."),4248413). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnIronSulfurproteinsasdonorsdinitrogenasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","iron-sulfur","protein","acts","as","a","hydrogen","or","electron","donor","and","reduces","dinitrogen","."),4276676). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnIronSulfurproteinsasdonorsnadornadpasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","iron-sulfur","protein","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","or","NADP","."),4208619). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnIronSulfurproteinsasdonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","iron-sulfur","protein","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4208616). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnOtherNitrogenousCompoundsAsDonorsIronSulfurproteinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","nitrogenous","group",",","excluding","NH","and","NH2","groups",",","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","iron-sulfur","protein","."),4305640). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygen2Oxoglutarateasonedonorandincorporationofoneatomeachofoxygenintobothdonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","2-oxoglutarate","and","one","other","donor",",","and","one","atom","of","oxygen","is","incorporated","into","each","donor","."),4175169). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenReducedIronSulfurproteinasonedonorandincorporationofoneatomofoxygen',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","reduced","iron-sulfur","protein","and","one","other","donor",",","and","one","atom","of","oxygen","is","incorporated","into","one","donor","."),4180900). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnPairedDonorsWithIncorporationOrReductionOfMolecularOxygenWith2Oxoglutarateasonedonorandtheotherdehydrogenated',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","hydrogen","or","electrons","are","transferred","from","2-oxoglutarate","and","one","other","donor",",","and","the","latter","donor","is","dehydrogenated","."),4265945). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheAldehydeOrOxoGroupOfDonorsIronSulfurproteinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","an","aldehyde","or","ketone","(","oxo",")","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","iron-sulfur","protein","."),4237721). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHChgroupofdonorscytochromeasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-CH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","cytochrome","."),4181982). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHChgroupofdonorsironSulfurproteinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-CH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","iron-sulfur","protein","."),4277917). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHChgroupofdonorsnadornadpasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-CH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","or","NADP","."),4186369). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHChgroupofdonorsotheracceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-CH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","quinone","or","related","compound",",","a","cytochrome",",","an","iron-sulfur","protein",",","NAD",",","NADP","or","oxygen","."),4305766). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHChgroupofdonorsoxygenasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-CH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","oxygen","."),4186289). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHChgroupofdonorsquinoneorrelatedcompoundasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-CH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","quinone","or","related","compound","."),4178959). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHChgroupofdonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-CH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4177834). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNh2groupofdonorscytochromeasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","cytochrome","molecule","."),4305744). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNh2groupofdonorsdisulfideasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","disulfide","group","."),4207263). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNh2groupofdonorsironSulfurproteinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","iron-sulfur","protein","."),4303481). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNh2groupofdonorsnadornadpasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","+","or","NADP","."),4207643). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNh2groupofdonorsotheracceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","a","cytochrome",",","disulfide",",","an","iron-sulfur","protein",",","NAD",",","NADP","or","oxygen","."),4305755). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNh2groupofdonorsoxygenasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","oxygen","molecule","."),4186638). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNh2groupofdonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4186424). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNh2groupofdonorswithaquinoneorsimilarcompoundasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH2","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","quinone","or","similar","compound","."),4186427). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNhgroupofdonorsdisulfideasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","disulfide","."),4200829). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNhgroupofdonorsflavinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","flavin","."),4266194). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNhgroupofdonorsironSulfurproteinasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","iron-sulfur","protein","."),4228346). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNhgroupofdonorsnadornadpasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","or","NADP","."),4165078). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNhgroupofdonorsotheracceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","quinone","or","similar","compound",",","disulfide",",","NAD",",","NADP",",","oxygen","or","a","flavin","."),4305663). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNhgroupofdonorsoxygenasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","oxygen","."),4237109). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNhgroupofdonorsquinoneorsimilarcompoundasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","quinone","or","similar","compound","."),4211028). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHNhgroupofdonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-NH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor","."),4165075). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHOhgroupofdonorscytochromeasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-OH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","cytochrome","molecule","."),4205748). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHOhgroupofdonorsdisulfideasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-OH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","disulfide","molecule","."),4302187). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHOhgroupofdonorsnadornadpasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-OH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","+","or","NADP","."),4157658). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHOhgroupofdonorsotheracceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-OH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","acceptor","other","than","a","cytochrome",",","disulfide",",","NAD",",","NADP",",","oxygen","or","a","quinone","or","similar","compound","."),4302178). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHOhgroupofdonorsoxygenasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-OH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","an","oxygen","molecule","."),4186882). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnTheCHOhgroupofdonorsquinoneorsimilarcompoundasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-OH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","quinone","or","a","similar","acceptor","molecule","."),4186608). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnXHandyHtoformanxYbond',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","X-H","and","Y-H","form","X-Y","."),4266114). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnXHandyHtoformanxYbondwithadisulfideasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","X-H","and","Y-H","form","X-Y","and","the","acceptor","is","disulfide","."),4266328). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnXHandyHtoformanxYbondwithotheracceptors',s("OBSOLETE",".","Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","X-H","and","Y-H","form","X-Y","and","the","acceptor","is","not","disulfide","or","oxygen","."),4266247). assertion_content_comment('oboGo_OxidoreductaseActivityActingOnXHandyHtoformanxYbondwithoxygenasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","X-H","and","Y-H","form","X-Y","and","the","acceptor","is","oxygen","."),4266117). assertion_content_comment('oboGo_OxidoreductionDrivenactivetransmembranetransporteractivity',s("Primary","active","transport","of","a","solute","across","a","membrane",",","driven","by","exothermic","flow","of","electrons","from","a","reduced","substrate","to","an","oxidized","substrate",".","Primary","active","transport","is","catalysis","of","the","transport","of","a","solute","across","a","membrane",",","up","the","solute","'","s","concentration","gradient",",","by","binding","the","solute","and","undergoing","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","primary","energy","source","."),4291729). assertion_content_comment('oboGo_OxoAcidLyaseactivity',s("Catalysis","of","the","cleavage","of","a","C-C","bond","by","other","means","than","by","hydrolysis","or","oxidation",",","of","a","3-hydroxy","acid","."),4206650). assertion_content_comment('oboGo_OxoglutarateDehydrogenaseNADPActivity_9',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","CoA","+","NAD","(","P",")","+","=","succinyl-CoA","+","CO2","+","NAD","(","P",")","H","."),4353897). assertion_content_comment('oboGo_OxoglutarateDehydrogenaseSuccinylTransferringactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","lipoamide","=","S-succinyldihydrolipoamide","+","CO2","."),4203948). assertion_content_comment('oboGo_OxygenDependentprotoporphyrinogenoxidaseactivity',s("Catalysis","of","the","reaction",":","3","O","(","2",")","+","protoporphyrinogen","IX","=","3","H","(","2",")","O","(","2",")","+","protoporphyrin","IX","."),4200918). assertion_content_comment('oboGo_OXylenebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","o-xylene",",","(","1",",","2-dimethylbenzene",")","a","colorless",",","liquid","aromatic","hydrocarbon","."),4353523). assertion_content_comment('oboGo_OXylenecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","o-xylene",",","(","1",",","2-dimethylbenzene",")","a","colorless",",","liquid","aromatic","hydrocarbon","."),4313708). assertion_content_comment('oboGo_OXylenemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","o-xylene",",","(","1",",","2-dimethylbenzene",")","a","colorless",",","liquid","aromatic","hydrocarbon","."),4272828). assertion_content_comment('oboGo_Oxysterol7AlphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","an","oxysterol","+","NADPH","+","O2","=","7-alpha-hydroxylated","oxysterol","+","NADP","+","+","H2O","."),4255595). assertion_content_comment('oboGo_PalmitoleoylAcylCarrierProteinDependentacyltransferaseactivity',s("Catalysis","of","the","reaction",":","a","palmitoleoyl-","[","acyl-carrier","protein","]","+","alpha-KDO-","(","2-","&","gt",";","4",")","-alpha-KDO-","(","2-","&","gt",";","6",")","-lipid","IVA","=","KDO2-","(","palmitoleoyl",")","-lipid","IVA","+","a","holo-","[","acyl-carrier","protein","]"),4247624). assertion_content_comment('oboGo_PalmitoylAcylCarrierProteinhydrolaseactivity',s("Catalysis","of","the","reaction",":","palmitoyl-","[","acyl-carrier","protein","]","+","H2O","=","[","acyl-carrier","protein","]","+","palmitate","."),4304653). assertion_content_comment('oboGo_PalmitoylCoa9Desaturaseactivity',s("Catalysis","of","the","reaction",":","palmitoyl-CoA","+","AH2","+","O2","=","palmitoleic","acid","(","16",":","1delta9",")","+","A","+","2","H2O","."),4337192). assertion_content_comment('oboGo_PalmitoylCoahydrolaseactivity',s("Catalysis","of","the","reaction",":","palmitoyl-CoA","+","H2O","=","CoA","+","palmitate","."),4304604). assertion_content_comment('oboGo_PalmitoylCoaoxidaseactivity',s("Catalysis","of","the","reaction",":","palmitoyl-CoA","+","O2","=","trans-2",",","3-dehydropalmitoyl-CoA","+","hydrogen","peroxide","."),4304811). assertion_content_comment('oboGo_PalmitoylProteinhydrolaseactivity',s("Catalysis","of","the","reaction",":","palmitoyl-protein","+","H2O","=","palmitate","+","protein","."),4254190). assertion_content_comment('oboGo_PAminobenzoatesynthetase',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4247615). assertion_content_comment('oboGo_PAminobenzoylGlutamatetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","p-aminobenzoyl-glutamate","from","one","side","of","a","membrane","to","the","other",".","p-aminobenzoyl-glutamate","is","the","anion","of","p-aminobenzoyl-glutamic","acid","."),4293381). assertion_content_comment('oboGo_PAminobenzoylGlutamatetransport',s("The","directed","movement","of","p-aminobenzoyl-glutamate",",","the","anion","of","p-aminobenzoyl-glutamic","acid",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293793). assertion_content_comment('oboGo_PAminobenzoylGlutamateuptaketransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","p-aminobenzoyl-glutamate","from","the","outside","of","a","cell","to","the","inside","of","the","cell","across","a","membrane","."),4293384). assertion_content_comment('oboGo_PanNeuralprocess',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4234726). assertion_content_comment('oboGo_PantetheinePhosphateadenylyltransferaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","pantetheine","4","'","-phosphate","=","3","'","-dephospho-CoA","+","diphosphate","."),4204041). assertion_content_comment('oboGo_Pantoate4Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-pantoate","+","NAD","(","+",")","=","(","R",")","-4-dehydropantoate","+","H","(","+",")","+","NADH","."),4271265). assertion_content_comment('oboGo_PantoateBetaAlanineligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","(","R",")","-pantoate","+","beta-alanine","=","AMP","+","diphosphate","+","(","R",")","-pantothenate","."),4203933). assertion_content_comment('oboGo_PantothenateBiosyntheticProcessFrom2Oxypantoyllactone',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pantothenate",",","the","anion","of","pantothenic","acid",",","from","other","compounds",",","including","2-oxypantoyl","lactone","."),4339044). assertion_content_comment('oboGo_Par3ApcKif3acomplex',s("A","protein","complex","that","contains","Par3",",","the","tumor","suppressor","protein","adenomatous","polyposis","coli","(","APC",")",",","and","the","kinesin-related","protein","KIF3A",";","involved","in","establishing","neuronal","cell","polarity","."),4349462). assertion_content_comment('oboGo_ParaAminobenzoicacidbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","para-aminobenzoic","acid",",","an","intermediate","in","the","synthesis","of","folic","acid",",","a","compound","which","some","organisms",",","e.g",".","prokaryotes",",","eukaryotic","microbes",",","and","plants",",","can","synthesize","de","novo",".","Others",",","notably","mammals",",","cannot",".","In","yeast",",","it","is","present","as","a","factor","in","the","B","complex","of","vitamins","."),4245700). assertion_content_comment('oboGo_ParaAminobenzoicacidmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","para-aminobenzoic","acid",",","an","intermediate","in","the","synthesis","of","folic","acid",",","a","compound","which","some","organisms",",","e.g",".","prokaryotes",",","eukaryotic","microbes",",","and","plants",",","can","synthesize","de","novo",".","Others",",","notably","mammals",",","cannot",".","In","yeast",",","it","is","present","as","a","factor","in","the","B","complex","of","vitamins","."),4245689). assertion_content_comment('oboGo_ParaAminobenzoicacidpabasynthase',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4245854). assertion_content_comment('oboGo_ParaAminobenzoylGlutamatehydrolaseactivity',s("Catalysis","of","the","reaction",":","para-aminobenzoyl-glutamate","+","H2O","=","para-aminobenzoate","+","L-glutamate","."),4170159). assertion_content_comment('oboGo_PassiveInductionOfHostCellMediatedimmuneresponsebyvirus',s("The","unintentional","stimulation","by","a","virus","of","a","cell-mediated","host","defense","response","to","viral","infection",",","as","part","of","the","viral","infectious","cycle","."),4357051). assertion_content_comment('oboGo_PathogenAssociatedmolecularpatterndependentinductionbyorganismofinnateimmunityofotherorganisminvolvedinsymbioticinteraction',s("Any","process","that","involves","recognition","of","a","pathogen-associated","molecular","pattern",",","and","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195076). assertion_content_comment('oboGo_PathogenAssociatedmolecularpatterndependentinductionbyorganismofsymbiontinnateimmunity',s("OBSOLETE",".","This","term","was","not","defined","before","being","made","obsolete","."),4187519). assertion_content_comment('oboGo_PathogenAssociatedmolecularpatterndependentinductionbysymbiontofhostinnateimmunity',s("Any","process","that","involves","recognition","of","a","pathogen-associated","molecular","pattern",",","and","by","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","the","host","organism",";","the","innate","immune","response","is","the","host","'","s","first","line","of","defense","against","infection",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195085). assertion_content_comment('oboGo_PathogenAssociatedmolecularpatterndependentmodulationbyorganismofinnateimmunityinotherorganisminvolvedinsymbioticinteraction',s("Any","process","that","involves","recognition","of","a","pathogen-associated","molecular","pattern",",","and","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","innate","immune","response",",","the","first","line","of","defense","against","infection",",","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195061). assertion_content_comment('oboGo_PathogenAssociatedmolecularpatterndependentmodulationbyorganismofsymbiontinnateimmunity',s("OBSOLETE",".","This","term","was","not","defined","before","being","made","obsolete","."),4187414). assertion_content_comment('oboGo_PathogenAssociatedmolecularpatterndependentmodulationbysymbiontofhostinnateimmunity',s("Any","process","that","involves","recognition","of","a","pathogen-associated","molecular","pattern",",","and","by","which","an","organism","modulates","the","frequency",",","rate","or","extent","of","the","innate","immune","response","of","the","host","organism",";","the","innate","immune","response","is","the","host","'","s","first","line","of","defense","against","infection",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4195064). assertion_content_comment('oboGo_PathwayRestrictedsmadproteinphosphorylation',s("The","process","of","introducing","a","phosphate","group","on","to","a","pathway","restricted","SMAD","protein",".","A","pathway","restricted","SMAD","protein","is","an","effector","protein","that","acts","directly","downstream","of","the","transforming","growth","factor","family","receptor","."),4037058). assertion_content_comment('oboGo_PathwaySpecificsmadprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4215355). assertion_content_comment('oboGo_PBenzoquinonereductasenadphactivity',s("Catalysis","of","the","reaction",":","1",",","4-benzoquinone","+","H","(","+",")","+","NADPH","=","hydroquinone","+","NADP","(","+",")"),4279030). assertion_content_comment('oboGo_PCNAP21complex',s("A","protein","complex","that","contains","the","cyclin-dependent","protein","kinase","inhibitor","p21WAF1/CIP1","bound","to","PCNA",";","formation","of","the","complex","inhibits","DNA","replication","."),4174610). assertion_content_comment('oboGo_PCoumarate3Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","shikimate","or","quinate","ester","of","p-coumaric","acid","+","NADPH","+","H","+","+","O2","=","caffeic","acid","conjugate","(","caffeoyl","shikimic","acid","or","chlorogenic","acid",")","+","H2O","+","NADP","+"),4351334). assertion_content_comment('oboGo_PCumate23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","p-cumate","+","NADH","+","H","+","+","O2","=","NAD","+","+","cis-2",",","3-dihydroxy-2",",","3-dihydro-p-cumate","."),4278680). assertion_content_comment('oboGo_PCymenecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","p-cymene",",","1-methyl-4-isopropylbenzene",",","one","of","the","alkyl-substituted","aromatic","hydrocarbons","found","in","volatile","oils","from","over","100","plants","."),4240573). assertion_content_comment('oboGo_PCymenemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","p-cymene",",","1-methyl-4-isopropylbenzene",",","one","of","the","alkyl-substituted","aromatic","hydrocarbons","found","in","volatile","oils","from","over","100","plants","."),4240569). assertion_content_comment('oboGo_PCymenemethylhydroxylaseactivity',s("Catalysis","of","the","reaction",":","p-cymene","+","NADH","+","O2","=","NAD","+","+","OH-","+","p-cumic","alcohol","."),4276645). assertion_content_comment('oboGo_PDX1Pbx1bMrg1complex',s("A","protein","complex","that","contains","the","homeodomain","proteins","PDX1",",","PBX1b","and","MRG1","(","MEIS2",")","and","is","involved","in","the","transcriptional","regulation","of","pancreatic","acinar","cell-specific","genes","."),4348559). assertion_content_comment('oboGo_PectateDisaccharideLyaseactivity',s("Catalysis","of","the","eliminative","cleavage","of","4-","(","4-deoxy-a-D-galact-4-enuronosyl",")","-D-galacturonate","from","the","reducing","end","of","pectate",",","i.e",".","de-esterified","pectin","."),4369753). assertion_content_comment('oboGo_Pelargonidin3OGlucosidebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","pelargonidin","3-O-glucoside",",","a","basic","anthocyanin","responsible","for","red","to","magenta","coloration","of","flowers","and","fruits","."),4339318). assertion_content_comment('oboGo_PElementbinding',s("Interacting","selectively","and","non-covalently","with","any","P-element",",","a","class","of","Drosophila","transposon","responsible","for","hybrid","dysgenesis","."),4193331). assertion_content_comment('oboGo_PentaSnrnpcomplex',s("A","ribonucleoprotein","complex","formed","by","the","association","of","the","U1",",","U2",",","U4/U6","and","U5","small","nuclear","ribonucleoproteins","."),4167613). assertion_content_comment('oboGo_PentosePhosphateshuntnonOxidativebranch',s("The","branch","of","the","pentose-phosphate","shunt","which","does","not","involve","oxidation","reactions",".","It","comprises","a","series","of","sugar","phosphate","interconversions",",","starting","with","ribulose","5-P","and","producing","fructose","6-P","and","glyceraldehyde","3-P","."),4021231). assertion_content_comment('oboGo_PentosePhosphateshuntoxidativebranch',s("The","branch","of","the","pentose-phosphate","shunt","which","involves","the","oxidation","of","glucose","6-P","and","produces","ribulose","5-P",",","reduced","NADP","+","and","carbon","dioxide","(","CO2",")"),4021215). assertion_content_comment('oboGo_PentosePhosphateshunt',s("The","process","in","which","glucose","is","oxidized",",","coupled","to","NADPH","synthesis",".","Glucose","6-P","is","oxidized","with","the","formation","of","carbon","dioxide","(","CO2",")",",","ribulose","5-phosphate","and","reduced","NADP",";","ribulose","5-P","then","enters","a","series","of","reactions","interconverting","sugar","phosphates",".","The","pentose","phosphate","pathway","is","a","major","source","of","reducing","equivalents","for","biosynthesis","reactions","and","is","also","important","for","the","conversion","of","hexoses","to","pentoses","."),4021189). assertion_content_comment('oboGo_PeptidaseActivityActingOnDAminoacidpeptides',s("Catalysis","of","the","hydrolysis","of","peptide","bonds","formed","between","D-amino","acids","."),4180766). assertion_content_comment('oboGo_PeptidaseActivityActingOnLAminoacidpeptides',s("Catalysis","of","the","hydrolysis","of","peptide","bonds","formed","between","L-amino","acids","."),4168565). assertion_content_comment('oboGo_PeptideAcetylCoasecondaryactivetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","peptide-acetyl-CoA","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","chemiosmotic","source","of","energy",".","Chemiosmotic","sources","of","energy","include","uniport",",","symport","or","antiport","."),4296393). assertion_content_comment('oboGo_PeptideAlphaNAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","peptide","=","CoA","+","N-alpha-acetylpeptide",".","This","reaction","is","the","acetylation","of","the","N-terminal","amino","acid","residue","of","a","peptide","or","protein","."),4204022). assertion_content_comment('oboGo_PeptideAntigenTransportingatpaseactivity',s("Catalysis","of","the","reaction",":","peptide","antigen","(","in",")","+","ATP","=","peptide","antigen","(","out",")","+","ADP","+","phosphate","."),4291879). assertion_content_comment('oboGo_PeptideAspartatebetaDioxygenaseactivity',s("Catalysis","of","the","reaction",":","peptide","L-aspartate","+","2-oxoglutarate","+","O2","=","peptide","3-hydroxy-L-aspartate","+","succinate","+","CO2","."),4204076). assertion_content_comment('oboGo_PeptideCrossLinking',s("The","formation","of","a","covalent","cross-link","between","or","within","protein","chains","."),4040471). assertion_content_comment('oboGo_PeptideCross_LinkingVia2_Amino_3_Isothiazolidinone_L_Serine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","cysteine-peptidyl","serine","cross-link","through","a","process","of","forming","first","an","intermediate","cysteine","sulfenic","acid","by","peroxide","oxidation",",","followed","by","condensation","with","the","alpha-amido","of","the","following","serine","residue","and","the","release","of","water","."),4385308). assertion_content_comment('oboGo_PeptideCrossLinkingvia2IminoGlutamicacid5Imidazolinoneglycine',s("The","formation","of","the","non-fluorescent","protein","chromophore","cross-link","from","the","alpha-carboxyl","carbon","of","residue","n",",","a","glutamic","acid",",","to","the","alpha-amino","nitrogen","of","residue","n","+","2",",","a","glycine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","1",".","This","cross-linking","is","coupled","with","a","dehydrogenation","of","residue","n","+","1","to","form","a","double","bond","between","the","alpha","and","beta","carbons",".","This","modification","is","found","in","the","GFP-like","non-fluorescent","red","chromoprotein","from","the","sea","anemone","Radianthus","macrodactylus","."),4285940). assertion_content_comment('oboGo_PeptideCross_LinkingVia2_Imino_Glutaminyl_5_ImidazolinoneGlycine',s("The","formation","of","the","fluorescent","protein","FP583","chromophore","cross-link","from","the","alpha-carboxyl","carbon","of","residue","n",",","a","glutamine",",","to","the","alpha-amino","nitrogen","of","residue","n","+","2",",","a","glycine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","1",".","This","cross-linking","is","coupled","with","a","dehydrogenation","of","residue","n","+","1","to","form","a","double","bond","between","the","alpha","and","beta","carbons","."),4245213). assertion_content_comment('oboGo_PeptideCrossLinkingvia2IminoMethionine5Imidazolinoneglycine',s("The","formation","of","the","fluorescent","protein","FP611","chromophore","cross-link","from","the","alpha-carboxyl","carbon","of","residue","n",",","a","methionine",",","to","the","alpha-amino","nitrogen","of","residue","n","+","2",",","a","glycine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","1",".","This","cross-linking","is","coupled","with","a","dehydrogenation","of","residue","n","+","1","to","form","a","double","bond","between","the","alpha","and","beta","carbons",".","This","modification","is","found","in","the","GFP-like","fluorescent","chromoprotein","from","the","sea","anemone","Entacmaea","quadricolor","."),4285925). assertion_content_comment('oboGo_PeptideCrossLinkingvia2r6rLanthionine',s("The","formation","of","a","protein-protein","cross-link","between","peptidyl-serine","and","peptidyl-cysteine","by","the","synthesis","of","(","2R",",","6R",")","-lanthionine","(","L-lanthionine",")"),4284770). assertion_content_comment('oboGo_PeptideCross_LinkingVia2S3S4Xi6R_3_Methyl_LanthionineSulfoxide',s("The","formation","of","a","protein-protein","cross-link","between","peptidyl-threonine","and","peptidyl-cysteine","by","the","synthesis","of","(","2S",",","3S",",","4Xi",",","6R",")","-3-methyl-lanthionine","sulfoxide","(","3-methyl-L-lanthionine","sulfoxide",")",",","as","found","in","the","antibiotic","actagardine","."),4357870). assertion_content_comment('oboGo_PeptideCross_LinkingVia2S3S6R_3_Methyl_Lanthionine',s("The","formation","of","a","protein-protein","cross-link","between","peptidyl-threonine","and","peptidyl-cysteine","by","the","synthesis","of","(","2S",",","3S",",","6R",")","-3-methyl-lanthionine","(","3-methyl-L-lanthionine",")"),4284701). assertion_content_comment('oboGo_PeptideCrossLinkingvia2SLCysteinylDAlloThreonine',s("The","post-translational","cross-linking","of","a","cysteine","residue","to","an","L-threonine","residue","to","form","2-","(","S-L-cysteinyl",")","-D-allo-threonine","."),4362169). assertion_content_comment('oboGo_PeptideCrossLinkingvia2SLCysteinylDPhenylalanine',s("The","cross-linking","of","a","cysteine","residue","to","an","L-phenylalanine","residue","to","form","2-","(","S-L-cysteinyl",")","-D-phenylalanine","."),4362181). assertion_content_comment('oboGo_PeptideCrossLinkingvia2SLCysteinylLHistidine',s("The","modification","of","peptidyl-histidine","and","peptidyl-cysteine","to","form","a","2","'","-","(","S-L-cysteinyl",")","-L-histidine","protein","cross-link","."),4279906). assertion_content_comment('oboGo_PeptideCrossLinkingvia2SLCysteinylLPhenylalanine',s("The","cross-linking","of","a","cysteine","residue","to","an","L-phenylalanine","residue","to","form","2-","(","S-L-cysteinyl",")","-L-phenylalanine","."),4362193). assertion_content_comment('oboGo_PeptideCross_LinkingVia2_Tetrahydropyridinyl_5_ImidazolinoneGlycine',s("The","formation","of","a","2-tetrahydropyridinyl-5-imidazolinone","protein","chromophore","cross-link","from","the","alpha-carboxyl","carbon","of","residue","n",",","a","lysine",",","to","the","alpha-amino","nitrogen","of","residue","n","+","2",",","a","glycine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","1",".","This","cross-linking","is","coupled","with","a","dehydrogenation","of","residue","n","+","1","to","form","a","double","bond","between","the","alpha","and","beta","carbons",".","In","addition",",","the","residue","N","lysine","undergoes","cyclization",".","The","alpha-amino","nitrogen","is","replaced","by","the","epsilon-amino","nitrogen",",","the","peptide","chain","is","broken",",","residue","N-1","is","released","as","an","amide",",","and","a","double","bond","is","formed","between","the","alpha-carbon","and","the","nitrogen","so","that","a","tetrahydropyridine","ring","results",".","This","modification","is","found","in","the","GFP-like","fluorescent","chromoprotein","FP538","from","the","sea","anemone","Zoanthus","species","."),4285870). assertion_content_comment('oboGo_PeptideCross_LinkingVia3_1_L_Histidyl_L_Tyrosine',s("The","modification","of","peptidyl-histidine","and","peptidyl-tyrosine","to","form","a","3","'","-","(","1","'","-L-histidyl",")","-L-tyrosine","protein","cross-link","."),4284746). assertion_content_comment('oboGo_PeptideCross_LinkingVia3_2_MethylthioEthyl_6_4_Hydroxybenzylidene_5_Iminopiperazin_2_One',s("The","formation","of","a","2-keto-5-iminopiperazine","protein","chromophore","cross-link","from","the","alpha-amino","nitrogen","of","residue","n",",","a","methionine",",","to","the","alpha-carboxyl","carbon","of","residue","n","+","1",",","a","tyrosine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","2",".","This","cross-linking","is","coupled","with","a","dehydrogenation","of","residue","n","+","1","to","form","a","double","bond","between","the","alpha","and","beta","carbons","."),4285955). assertion_content_comment('oboGo_PeptideCross_LinkingVia3_3_L_Histidyl_L_Tyrosine',s("The","modification","of","peptidyl-histidine","and","peptidyl-tyrosine","to","form","a","3-","(","3","'","-L-histidyl",")","-L-tyrosine","protein","cross-link","."),4284780). assertion_content_comment('oboGo_PeptideCross_LinkingVia3_3_L_Tyrosinyl_L_Tyrosine',s("The","modification","of","two","peptidyl-tyrosines","to","form","a","3","'","-","(","3","'","-L-tyrosinyl",")","-L-tyrosine","protein","cross-link","."),4307424). assertion_content_comment('oboGo_PeptideCrossLinkingvia3O4LTyrosinylLTyrosine',s("The","modification","of","two","peptidyl-tyrosines","to","form","a","3","'","-","(","O4","'","-L-tyrosinyl",")","-L-tyrosine","protein","cross-link","."),4307435). assertion_content_comment('oboGo_PeptideCrossLinkingvia3SLCysteinylLAsparticacid',s("The","cross-linking","of","a","cysteine","residue","to","an","aspartic","acid","residue","to","form","3-","(","S-L-cysteinyl",")","-L-aspartic","acid","."),4232974). assertion_content_comment('oboGo_PeptideCrossLinkingvia3SLCysteinylLTyrosine',s("The","thioether","cross-linking","of","a","cysteine","residue","to","a","tyrosine","residue","to","form","3","'","-","(","S-L-cysteinyl",")","-L-tyrosine",",","found","in","galactose","oxidase","."),4279918). assertion_content_comment('oboGo_PeptideCross_LinkingVia4_Amino_3_Isothiazolidinone',s("The","formation","of","4-amino-3-isothiazolinone","cross-links","by","the","formation","of","a","sulfenylamide","bond","between","cysteine","or","cysteine","sulfenic","acid",",","and","the","alpha-amido","of","the","following","residue","."),4385306). assertion_content_comment('oboGo_PeptideCrossLinkingvia4LTryptophanLTryptophylquinone',s("The","cross-linking","of","a","tryptophan","residue","to","tryptophyl","quinone","to","form","4","'","-","(","L-tryptophan",")","-L-tryptophyl","quinone",",","a","cofactor","found","at","the","active","site","of","methylamine","dehydrogenase","."),4042143). assertion_content_comment('oboGo_PeptideCrossLinkingvia4SLCysteinylLGlutamicacid',s("The","cross-linking","of","a","cysteine","residue","to","a","glutamic","acid","residue","to","form","4-","(","S-L-cysteinyl",")","-L-glutamic","acid","."),4232996). assertion_content_comment('oboGo_PeptideCrossLinkingvia4SLCysteinylLTryptophylquinone',s("The","cross-linking","of","a","cysteine","residue","to","tryptophyl","quinone","to","form","4","'","-","(","S-L-cysteinyl",")","-L-tryptophyl","quinone",",","a","cofactor","found","at","the","active","site","of","amine","dehydrogenase","."),4232747). assertion_content_comment('oboGo_PeptideCrossLinkingvia5Imidazolinoneglycine',s("The","formation","of","a","protein","active","site","cross-link","from","the","alpha-carboxyl","carbon","of","residue","n",",","an","alanine",",","serine","or","cysteine",",","to","the","alpha-amino","nitrogen","of","residue","n","+","2",",","a","glycine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","1",".","This","cross-linking","is","coupled","with","an","oxidation","of","residue","n","+","1","to","form","an","active","aldehyde","."),4275738). assertion_content_comment('oboGo_PeptideCrossLinkingvia5N6LLysineLTopaquinone',s("The","cross-linking","of","the","epsilon-amino","group","of","a","peptidyl-lysine","with","peptidyl-topaquinone",",","a","modified","tyrosine","residue","."),4285042). assertion_content_comment('oboGo_PeptideCrossLinkingviaanoxazoleorthiazole',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","serine-peptidyl","glycine",",","or","peptidyl","cysteine-peptidyl","glycine","cross-link","by","the","condensation","of","the","serine","hydroxyl","or","cysteine","thiol","with","the","carbonyl","of","the","preceding","residue","and","alpha-beta","dehydrogenation","."),4284685). assertion_content_comment('oboGo_PeptideCrossLinkingviachondroitin4Sulfateglycosaminoglycan',s("The","formation","of","a","cross-link","between","peptide","chains","mediated","by","a","chondroitin","4-sulfate","glycosaminoglycan","that","originates","from","a","typical","O-glycosidic","link","to","serine","of","one","chain",";","the","other","chain","is","esterified",",","via","the","alpha-carbon","of","its","C-terminal","Asp",",","to","C-6","of","an","internal","N-acetylgalactosamine","of","the","glycosaminoglycan","chain","."),4233515). assertion_content_comment('oboGo_PeptideCrossLinkingviaglycineoxazolecarboxylicacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","serine-peptidyl","glycine","cross-link","by","the","condensation","of","a","serine","hydroxyl","with","the","carbonyl","of","the","preceding","residue","and","alpha-beta","dehydrogenation","."),4284929). assertion_content_comment('oboGo_PeptideCrossLinkingviaglycinethiazolecarboxylicacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","cysteine-peptidyl","glycine","cross-link","by","the","condensation","of","a","cysteine","thiol","with","the","carbonyl","of","the","preceding","residue","and","alpha-beta","dehydrogenation","."),4284960). assertion_content_comment('oboGo_PeptideCross_LinkingViaL_Alanyl_5_ImidazolinoneGlycine',s("The","formation","of","a","protein","active","site","cross-link","from","the","alpha-carboxyl","carbon","of","residue","N",",","an","alanine",",","to","the","alpha-amino","nitrogen","of","residue","N","+","2",",","a","glycine",",","coupled","with","the","formation","of","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","N","+","1","which","loses","one","hydrogen",",","and","the","loss","of","a","molecule","of","water","."),4279398). assertion_content_comment('oboGo_PeptideCrossLinkingvialanthionineor3MethylLanthionine',s("The","synthesis","of","(","2R",",","6R",")","-lanthionine",",","sn-","(","2S",",","6R",")","-lanthionine","or","(","2S",",","3S",",","6R",")","-3-methyl-lanthionine",",","forming","an","intra-polypeptide","cross-link","between","peptidyl-cysteine",",","and","peptidyl-serine","or","peptidyl-threonine",";","dehydration","of","the","serine","or","threonine","residue","to","the","alpha",",","beta-unsaturated","amino","acid","is","the","first","step",";","a","bond","then","forms","between","the","ethylene","(","ethene",")","group","thus","formed","and","the","sulfur","atom","of","a","cysteine",",","with","the","inversion","of","the","configuration","of","the","alpha","carbon","of","the","serine","or","threonine","occurring","during","the","process","."),4284338). assertion_content_comment('oboGo_PeptideCrossLinkingvialAsparagine5Imidazolinoneglycine',s("The","formation","of","the","fluorescent","protein","FP506","chromophore","cross-link","from","the","alpha-carboxyl","carbon","of","residue","n",",","an","asparagine",",","to","the","alpha-amino","nitrogen","of","residue","n","+","2",",","a","glycine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","1",".","This","cross-linking","is","coupled","with","a","dehydrogenation","of","residue","n","+","1","to","form","a","double","bond","between","the","alpha","and","beta","carbons","."),4285896). assertion_content_comment('oboGo_PeptideCrossLinkingvialCysteineoxazolecarboxylicacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","serine-peptidyl","cysteine","cross-link","by","the","condensation","of","a","serine","hydroxyl","with","the","carbonyl","of","the","preceding","residue","and","alpha-beta","dehydrogenation","."),4284905). assertion_content_comment('oboGo_PeptideCrossLinkingvialCysteineoxazolinecarboxylicacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","serine-peptidyl","cysteine","cross-link","by","the","condensation","of","a","serine","hydroxyl","with","the","carbonyl","of","the","preceding","residue","."),4284917). assertion_content_comment('oboGo_PeptideCrossLinkingvialCysteinethiazolecarboxylicacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","cysteine-peptidyl","cysteine","cross-link","by","the","condensation","of","a","cysteine","thiol","with","the","carbonyl","of","the","preceding","residue","and","alpha-beta","dehydrogenation","."),4284869). assertion_content_comment('oboGo_PeptideCross_LinkingViaL_Cysteinyl_5_ImidazolinoneGlycine',s("The","formation","of","a","protein","active","site","cross-link","from","the","alpha-carboxyl","carbon","of","residue","N",",","a","cysteine",",","to","the","alpha-amino","nitrogen","of","residue","N","+","2",",","a","glycine",",","coupled","with","the","formation","of","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","N","+","1","which","loses","one","hydrogen",",","and","the","loss","of","a","molecule","of","water","."),4275742). assertion_content_comment('oboGo_PeptideCrossLinkingvialCysteinylLSelenocysteine',s("The","formation","of","a","selenide-sulfide","bond","to","form","the","cystine-like","L-cysteinyl-L-selenocysteine",",","as","in","vertebrate","selenopeptide","P","."),4274510). assertion_content_comment('oboGo_PeptideCrossLinkingvialCystine',s("The","oxidation","of","two","peptidyl-cysteine","residues","to","form","a","peptidyl-L-cystine","(","dicysteine",")","in","which","segments","of","peptide","chain","are","linked","by","a","disulfide","bond",";","the","cross-link","may","be","between","different","or","the","same","peptide","chain","."),4279377). assertion_content_comment('oboGo_PeptideCrossLinkingvialHistidylLTyrosine',s("The","modification","of","peptidyl-histidine","and","peptidyl-tyrosine","to","form","a","protein","cross-link","."),4284744). assertion_content_comment('oboGo_PeptideCrossLinkingvialLysine5Imidazolinoneglycine',s("The","formation","of","a","fluorescent","protein","chromophore","cross-link","from","the","alpha-carboxyl","carbon","of","residue","n",",","a","lysine",",","to","the","alpha-amino","nitrogen","of","residue","n","+","2",",","a","glycine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","1",".","This","cross-linking","is","coupled","with","a","dehydrogenation","of","residue","n","+","1","to","form","a","double","bond","between","the","alpha","and","beta","carbons","."),4285910). assertion_content_comment('oboGo_PeptideCrossLinkingvialLysinethiazolecarboxylicacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","cysteine-peptidyl","lysine","cross-link","by","the","condensation","of","a","cysteine","thiol","with","the","carbonyl","of","the","preceding","residue","and","alpha-beta","dehydrogenation","."),4284858). assertion_content_comment('oboGo_PeptideCrossLinkingvialLysinoalanine',s("The","modification","of","peptidyl-lysine","and","peptidyl-serine","to","form","a","(","2Xi",",","9S",")","-L-lysinoalanine","cross-link","."),4280558). assertion_content_comment('oboGo_PeptideCrossLinkingvialPhenylalaninethiazolecarboxylicacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","cysteine-peptidyl","phenylalanine","cross-link","by","the","condensation","of","a","cysteine","thiol","with","the","carbonyl","of","the","preceding","residue","and","alpha-beta","dehydrogenation","."),4284893). assertion_content_comment('oboGo_PeptideCrossLinkingvialSerinethiazolecarboxylicacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","peptidyl","cysteine-peptidyl","serine","cross-link","by","the","condensation","of","a","cysteine","thiol","with","the","carbonyl","of","the","preceding","residue","and","alpha-beta","dehydrogenation","."),4284881). assertion_content_comment('oboGo_PeptideCross_LinkingViaL_Seryl_5_ImidazolinoneGlycine',s("The","formation","of","the","green","fluorescent","protein","chromophore","cross-link","from","the","alpha-carboxyl","carbon","of","residue","n",",","a","serine",",","to","the","alpha-amino","nitrogen","of","residue","n","+","2",",","a","glycine",",","and","a","dehydration","to","form","a","double","bond","to","the","alpha-amino","nitrogen","of","residue","n","+","1",".","This","cross-linking","is","coupled","with","a","dehydrogenation","of","residue","n","+","1","to","form","a","double","bond","between","the","alpha","and","beta","carbons","."),4280218). assertion_content_comment('oboGo_PeptideCrossLinkingvian6LIsoaspartylLLysinepresumedcatalytic',s("The","formation","of","isopeptide","bonds","by","ligation","of","peptidyl-lysine","and","peptidyl-asparagine","residues",";","occurs","in","mammals","in","proteins","as","yet","unidentified","by","a","mechanism","probably","analogous","to","that","of","transglutaminase","reactions","."),4233069). assertion_content_comment('oboGo_PeptideCrossLinkingvian6LIsoaspartylLLysine',s("The","formation","of","isopeptide","bonds","by","ligation","of","peptidyl-lysine","and","peptidyl-asparagine","residues","."),4233067). assertion_content_comment('oboGo_PeptideCross_LinkingViaS_2_Aminovinyl_3_Methyl_D_Cysteine',s("The","formation","of","a","cross-link","between","peptidyl-cysteine","and","peptidyl-threonine","via","the","formation","of","S-","(","2-aminovinyl",")","-3-methyl-D-cysteine","."),4284633). assertion_content_comment('oboGo_PeptideCross_LinkingViaS_2_Aminovinyl_D_Cysteine',s("The","synthesis","of","(","S",",","Z",")","-S-","(","2-aminovinyl",")","cysteine","forming","an","intra-polypeptide","cross-link","between","serine","and","cysteine","."),4284308). assertion_content_comment('oboGo_PeptideCross_LinkingViaS_5_L_Tryptoph_6_Yl_L_Tyrosin_3_Yl_L_Methionin_S_Ium',s("The","cross-linking","of","a","tyrosine","residue","to","a","tryptophan","residue","and","a","methionine","residue","to","form","S-","[","5","'","-","(","L-tryptoph-6","'","-yl",")","-L-tyrosin-3","'","-yl","]","-L-methionin-S-ium","."),4275834). assertion_content_comment('oboGo_PeptideCrossLinkingviasGlycylLCysteine',s("The","formation","of","S-","(","peptidyl-glycyl",")","-peptidyl-cysteine","cross-links","by","the","formation","of","a","thiolester","between","cysteine","and","the","carboxy-terminal","glycine","of","ubiquitin","and","other","proteins","."),4280244). assertion_content_comment('oboGo_PeptideCrossLinkingviasLIsoglutamylLCysteine',s("The","modification","of","peptidyl-glutamine","and","peptidyl-cysteine","to","form","a","S-","(","L-isoglutamyl",")","-L-cysteine","protein","cross-link","."),4279971). assertion_content_comment('oboGo_PeptideCross_LinkingViaSn_2S6R_Lanthionine',s("The","formation","of","a","protein-protein","cross-link","between","peptidyl-serine","and","peptidyl-cysteine","by","the","synthesis","of","sn-","(","2S",",","6R",")","-lanthionine","(","meso-lanthione",")"),4284758). assertion_content_comment('oboGo_PeptideMatingPheromoneMaturationInvolvedInPheromoneInducedunidirectionalconjugation',s("The","formation","of","a","mature","peptide","mating","pheromone","by","proteolysis","and/or","modification","of","a","peptide","precursor",",","occurring","in","the","context","of","pheromone-induced","unidirectional","conjugation","."),4130987). assertion_content_comment('oboGo_PeptideMethioninerSOxidereductaseactivity',s("Catalysis","of","the","reaction",":","L-methionine","residue","+","H","(","2",")","O","+","thioredoxin","disulfide","=","L-methionine","(","R",")","-S-oxide","residue","+","thioredoxin","."),4342497). assertion_content_comment('oboGo_PeptideMethionineSSOxidereductaseactivity',s("Catalysis","of","the","reactions",":","peptide-L-methionine","+","thioredoxin","disulfide","+","H2O","=","peptide-L-methionine","(","S",")","-S-oxide","+","thioredoxin",",","and","L-methionine","+","thioredoxin","disulfide","+","H2O","=","L-methionine","(","S",")","-S-oxide","+","thioredoxin","."),4246266). assertion_content_comment('oboGo_PeptideN4NAcetylBetaGlucosaminylasparagineamidaseactivity',s("Catalysis","of","the","reaction",":","4-N-","(","N-acetyl-D-glucosaminyl",")","-protein","+","H2O","=","N-acetyl-beta-D-glucosaminylamine","+","peptide","L-aspartate",".","This","reaction","is","the","hydrolysis","of","an","N4-","(","acetyl-beta-D-glucosaminyl",")","asparagine","residue","in","which","the","N-acetyl-D-glucosamine","residue","may","be","further","glycosylated",",","to","yield","a","(","substituted",")","N-acetyl-beta-D-glucosaminylamine","and","the","peptide","containing","an","aspartic","residue","."),4346279). assertion_content_comment('oboGo_PeptideNAcetyltransferaseactivity',s("Catalysis","of","the","acetylation","of","an","amino","acid","residue","of","a","peptide","or","protein",",","according","to","the","reaction",":","acetyl-CoA","+","peptide","=","CoA","+","N-acetylpeptide","."),4204020). assertion_content_comment('oboGo_PeptideOFucosyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","alpha-L-fucosyl","residue","from","GDP-","beta-L-fucose","to","the","serine","hydroxy","group","of","a","protein","acceptor","."),4362202). assertion_content_comment('oboGo_PeptideReceptorActivityGProteincoupled',s("Combining","with","an","extracellular","or","intracellular","peptide","to","initiate","a","G-protein","mediated","change","in","cell","activity",".","A","G-protein","is","a","signal","transduction","molecule","that","alternates","between","an","inactive","GDP-bound","and","an","active","GTP-bound","state","."),4159873). assertion_content_comment('oboGo_PeptideTransportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","peptide","(","in",")","=","ADP","+","phosphate","+","peptide","(","out",")","Peptides","exported","include","alpha-hemolysin",",","cyclolysin",",","colicin","V","and","siderophores","from","Gram-negative","bacteria",",","and","bacteriocin",",","subtilin",",","competence","factor","and","pediocin","from","Gram-positive","bacteria","."),4291605). assertion_content_comment('oboGo_PeptideTryptophan23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","peptide","tryptophan","+","O2","=","peptide","formylkynurenine","."),4271160). assertion_content_comment('oboGo_PeptidoglycanAssociatedpeptidetransport',s("The","directed","movement","of","peptidoglycan","peptides","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Peptidoglycan","peptides","are","the","oligopeptides","found","in","peptidoglycan","networks","which","cross-link","the","polysaccharide","chains","."),4293966). assertion_content_comment('oboGo_PeptidoglycanBasedcellwallbiogenesis',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","peptidoglycan-based","cell","wall",".","An","example","of","this","process","is","found","in","Escherichia","coli","."),4024080). assertion_content_comment('oboGo_PeptidoglycanBasedcellwallorganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","peptidoglycan-based","cell","wall","."),4321741). assertion_content_comment('oboGo_PeptidoglycanBasedcellwall',s("A","protective","structure","outside","the","cytoplasmic","membrane","composed","of","peptidoglycan","(","also","known","as","murein",")",",","a","molecule","made","up","of","a","glycan","(","sugar",")","backbone","of","repetitively","alternating","N-acetylglucosamine","and","N-acetylmuramic","acid","with","short",",","attached",",","cross-linked","peptide","chains","containing","unusual","amino","acids",".","An","example","of","this","component","is","found","in","Escherichia","coli","."),4023807). assertion_content_comment('oboGo_PeptidoglycanBetaNAcetylmuramidaseactivity',s("Catalysis","of","the","hydrolysis","of","terminal",",","non-reducing","N-acetylmuramic","residues","."),4344652). assertion_content_comment('oboGo_PeptidoglycanLDTranspeptidaseactivity',s("Catalysis","of","the","reaction",":","2","a","peptidoglycan","dimer","(","tetrapeptide",")","+","3","H2O","=","a","peptidoglycan","tetramer","with","L",",","D","cross-links","(","L-Lys-D-Asn-L-Lys",")","+","di-trans",",","poly-cis-undecaprenyl","diphosphate","+","4","D-alanine","."),4168608). assertion_content_comment('oboGo_PeptidoglycanProteincrossLinking',s("The","process","of","covalently","linking","peptidoglycan","(","murein",")","to","proteins","."),4237231). assertion_content_comment('oboGo_PeptidoglycanProteincrossLinkingvialAlanylPentaglycylMurein',s("The","process","of","linking","a","protein","to","peptidoglycan","via","a","carboxy","terminal","alanine","carboxyl","group","through","a","pentaglycyl","peptide","to","the","lysine","or","diaminopimelic","acid","of","the","peptidoglycan","."),4285884). assertion_content_comment('oboGo_PeptidoglycanProteincrossLinkingvialThreonylPentaglycylMurein',s("The","process","of","linking","a","protein","to","peptidoglycan","via","a","carboxy","terminal","threonine","carboxyl","group","through","a","pentaglycyl","peptide","to","the","lysine","or","diaminopimelic","acid","of","the","peptidoglycan","."),4316024). assertion_content_comment('oboGo_PeptidoglycanProteincrossLinkingvian6MureinylLLysine',s("The","process","of","linking","a","protein","to","peptidoglycan","via","the","epsilon","amino","group","of","lysine","to","the","diaminopimelic","acid","of","the","peptidoglycan","."),4237234). assertion_content_comment('oboGo_Peptidyl_1_ThioglycineBiosyntheticProcessCarboxy_Terminal',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","carboxy-terminal","peptidyl-1-thioglycine",",","which","has","a","carboxy-terminal","thiocarboxy-C","(","=","O",")","-SH","bond","."),4232788). assertion_content_comment('oboGo_Peptidyl_1_ThioglycineBiosyntheticProcessFromPeptidyl_Glycine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptidyl-1-thioglycine","from","other","compounds",",","including","peptidyl-glycine","."),4040513). assertion_content_comment('oboGo_Peptidyl_1_ThioglycineBiosyntheticProcessInternal',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","internal","peptidyl-1-thioglycine",",","which","has","an","internal","C","=","S","bond",",","instead","of","an","internal","C","=","O","bond",",","in","the","peptide","."),4232801). assertion_content_comment('oboGo_Peptidyl_5_Hydroxy_L_LysineTrimethylation',s("The","methylation","of","5-hydroxy-L-lysine","to","form","peptidyl-N6",",","N6",",","N6-trimethyl-5-hydroxy-L-lysine","."),4274488). assertion_content_comment('oboGo_PeptidylAlaninemodification',s("The","modification","of","peptidyl-alanine","."),4232721). assertion_content_comment('oboGo_PeptidylAllysineoxidationto2Aminoadipicacid',s("The","oxidation","of","allysine","to","2-aminoadipic","acid","."),4245226). assertion_content_comment('oboGo_PeptidylAminoacidmodification',s("The","alteration","of","an","amino","acid","residue","in","a","peptide","."),4016684). assertion_content_comment('oboGo_PeptidylArginineadpRibosylation',s("The","transfer",",","from","NAD",",","of","ADP-ribose","to","peptidyl-arginine","to","form","omega-N-","(","ADP-ribosyl",")","-L-arginine","."),4285019). assertion_content_comment('oboGo_PeptidylArgininec5Methylation',s("The","methylation","of","peptidyl-arginine","on","the","carbon","5","(","C5",")","residue","to","form","peptidyl-5-methyl-L-arginine","."),4285654). assertion_content_comment('oboGo_PeptidylArgininecMethylation',s("The","addition","of","a","methyl","group","onto","a","carbon","atom","of","an","arginine","residue","in","a","protein","."),4285652). assertion_content_comment('oboGo_PeptidylArgininecMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","the","carbon","atom","of","an","arginine","residue","in","a","protein","."),4382552). assertion_content_comment('oboGo_Peptidyl_ArginineDihydroxylationToPeptidyl_34_Dihydroxy_L_Arginine',s("The","dihydroxylation","of","peptidyl-arginine","to","form","peptidyl-3",",","4-dihydroxy-L-arginine","."),4307330). assertion_content_comment('oboGo_PeptidylArgininehydroxylation',s("The","hydroxylation","of","peptidyl-arginine","to","form","peptidyl-hydroxyarginine","."),4285187). assertion_content_comment('oboGo_Peptidyl_ArginineHydroxylationToPeptidyl_4_Hydroxy_L_Arginine',s("The","hydroxylation","of","peptidyl-arginine","to","form","peptidyl-4-hydroxy-L-arginine","."),4285189). assertion_content_comment('oboGo_PeptidylArgininemethylation',s("The","addition","of","a","methyl","group","to","an","arginine","residue","in","a","protein","."),4232665). assertion_content_comment('oboGo_PeptidylArgininemethylationtoasymmetricalDimethylarginine',s("The","process","of","methylation","of","peptidyl-arginine","to","form","peptidyl-N","(","omega",")",",","N","(","omega",")","-dimethyl-L-arginine","."),4232671). assertion_content_comment('oboGo_PeptidylArgininemethylationtosymmetricalDimethylarginine',s("The","process","of","methylation","of","peptidyl-arginine","to","form","peptidyl-N","(","omega",")",",","N","'","(","omega",")","-dimethyl-L-arginine","."),4232736). assertion_content_comment('oboGo_PeptidylArgininemodification',s("The","modification","of","peptidyl-arginine","."),4232663). assertion_content_comment('oboGo_PeptidylArgininen5Methylation',s("The","methylation","of","peptidyl-arginine","on","the","internal","nitrogen-5","(","N5",")","atom","(","also","called","delta-nitrogen",")","to","form","peptidyl-N5-methyl-L-arginine","."),4245636). assertion_content_comment('oboGo_PeptidylArgininenMethylation',s("The","addition","of","a","methyl","group","onto","a","nitrogen","atom","of","an","arginine","residue","in","a","protein","."),4232667). assertion_content_comment('oboGo_PeptidylArginineomegaNMethylation',s("The","addition","of","a","methyl","group","onto","a","terminal","nitrogen","(","omega","nitrogen",")","atom","of","an","arginine","residue","in","a","protein","."),4232669). assertion_content_comment('oboGo_PeptidylArgininephosphorylation',s("The","phosphorylation","of","peptidyl-arginine","to","form","omega-N-phospho-L-arginine","."),4285154). assertion_content_comment('oboGo_PeptidylAsparagineadpRibosylation',s("The","transfer",",","from","NAD",",","of","ADP-ribose","to","peptidyl-asparagine","to","form","peptidyl-N4-","(","ADP-ribosyl",")","-L-asparagine","."),4285008). assertion_content_comment('oboGo_PeptidylAsparaginehydroxylation',s("The","hydroxylation","of","peptidyl-asparagine","to","form","peptidyl-hydroxyasparagine","."),4231221). assertion_content_comment('oboGo_PeptidylAsparaginehydroxylationtoformlErythroBetaHydroxyasparagine',s("The","hydroxylation","of","peptidyl-asparagine","to","form","peptidyl-L-erythro-beta-hydroxyasparagine",";","catalyzed","by","peptide-aspartate","beta-dioxygenase","(","EC",":","1.14.11.16",")"),4281927). assertion_content_comment('oboGo_PeptidylAsparaginemethylation',s("The","methylation","of","peptidyl-asparagine","to","form","peptidyl-N4-methyl-L-asparagine","or","peptidyl-N4",",","N4-dimethyl-L-asparagine","."),4245039). assertion_content_comment('oboGo_PeptidylAsparaginemodification',s("The","modification","of","peptidyl-asparagine","."),4168150). assertion_content_comment('oboGo_PeptidylAsparagineracemization',s("The","racemization","of","peptidyl-asparagine","."),4284296). assertion_content_comment('oboGo_PeptidylAsparticacidasparaginehydroxylation',s("OBSOLETE",".","The","hydroxylation","of","peptidyl-aspartic","acid","or","asparagine","."),4231225). assertion_content_comment('oboGo_PeptidylAsparticacidcarboxylation',s("The","carboxylation","of","peptidyl-aspartic","acid","to","form","peptidyl-L-beta-carboxyaspartic","acid","."),4233503). assertion_content_comment('oboGo_PeptidylAsparticacidhydroxylation',s("The","hydroxylation","of","peptidyl-aspartic","acid","to","form","peptidyl-hydroxyaspartic","acid","."),4231208). assertion_content_comment('oboGo_PeptidylAsparticacidhydroxylationtoformlErythroBetaHydroxyasparticacid',s("The","hydroxylation","of","peptidyl-aspartic","acid","to","form","peptidyl-L-erythro-beta-hydroxyaspartic","acid",";","catalyzed","by","peptide-aspartate","beta-dioxygenase","(","EC",":","1.14.11.16",")"),4245169). assertion_content_comment('oboGo_PeptidylAsparticacidmodification',s("The","modification","of","peptidyl-aspartic","acid","."),4231206). assertion_content_comment('oboGo_PeptidylAsparticacidphosphorylation',s("The","phosphorylation","of","peptidyl-aspartic","acid","."),4281603). assertion_content_comment('oboGo_PeptidylAsparticacidreductiontoformlAspartylaldehyde',s("The","reduction","of","peptidyl-aspartic","acid","to","form","peptidyl-L-aspartyl","aldehyde",",","as","found","photosystem","II","P680","chlorophyll","A","apoprotein","."),4287502). assertion_content_comment('oboGo_PeptidylBetaCarboxyasparticacidbiosyntheticprocessfrompeptidylAsparticacid',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptidyl-beta-carboxyaspartic","acid","from","other","compounds",",","including","peptidyl-aspartic","acid","."),4245108). assertion_content_comment('oboGo_PeptidylCitrullinebiosyntheticprocessfrompeptidylArginine',s("The","hydrolysis","of","peptidyl-arginine","to","form","peptidyl-citrulline","."),4285165). assertion_content_comment('oboGo_PeptidylCysteineacetylation',s("The","acetylation","of","peptidyl-cysteine","."),4278143). assertion_content_comment('oboGo_PeptidylCysteineadpRibosylation',s("The","transfer",",","from","NAD",",","of","ADP-ribose","to","peptidyl-cysteine","to","form","peptidyl-S-","(","ADP-ribosyl",")","-L-cysteine","."),4285030). assertion_content_comment('oboGo_PeptidylCysteinecyclaseactivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4284939). assertion_content_comment('oboGo_PeptidylCysteinedesulfurization',s("The","desulfurization","of","peptidyl-L-cysteine","to","yield","L-alanine","and","elemental","sulfur",";","peptidyl-L-cysteine","persulfide","is","an","intermediate","."),4284438). assertion_content_comment('oboGo_PeptidylCysteineesterification',s("The","addition","of","an","ester","group","to","a","cysteine","residue","in","a","protein","."),4280109). assertion_content_comment('oboGo_PeptidylCysteinemethylation',s("The","methylation","of","peptidyl-cysteine","to","form","peptidyl-S-methyl-L-cysteine","."),4279632). assertion_content_comment('oboGo_PeptidylCysteinemodification',s("The","modification","of","peptidyl-cysteine","."),4141559). assertion_content_comment('oboGo_PeptidylCysteineoxidation',s("The","oxidation","of","peptidyl-cysteine","to","peptidyl-L-cysteine","sulfinic","acid","or","peptidyl-L-cysteine","sulfenic","acid","."),4279597). assertion_content_comment('oboGo_PeptidylCysteinephosphorylation',s("The","phosphorylation","of","peptidyl-cysteine","to","form","peptidyl-S-phospho-L-cysteine","."),4279520). assertion_content_comment('oboGo_PeptidylCysteinesAcetylation',s("The","acetylation","of","peptidyl-cysteine","to","form","peptidyl-S-acetyl-L-cysteine","."),4279498). assertion_content_comment('oboGo_PeptidylCysteinesCarbamoylation',s("The","carbamoylation","of","peptidyl-cysteine","to","form","peptidyl-S-carbamoyl-L-cysteine","."),4357285). assertion_content_comment('oboGo_PeptidylCysteinesNitrosylaseactivity',s("Catalysis","of","the","transfer","of","a","nitric","oxide","(","NO",")","group","to","a","sulphur","atom","within","a","cysteine","residue","of","a","protein","."),4379814). assertion_content_comment('oboGo_PeptidylCysteinesNitrosylation',s("The","covalent","addition","of","a","nitric","oxide","(","NO",")","group","to","the","sulphur","(","S",")","atom","of","a","cysteine","residue","in","a","protein",",","to","form","peptidyl-S-nitrosyl-L-cysteine","."),4141561). assertion_content_comment('oboGo_PeptidylCysteinesTransNitrosylation',s("Transfer","of","a","nitric","oxide","(","NO",")","group","from","one","cysteine","residue","to","another","."),4379825). assertion_content_comment('oboGo_PeptidylDAlanineracemizationdirect',s("The","racemization","of","peptidyl-alanine","."),4232869). assertion_content_comment('oboGo_PeptidylDAlanineracemization',s("The","formation","of","peptidyl-D-alanine",",","by","either","racemization","or","from","peptidyl-L-serine","."),4232723). assertion_content_comment('oboGo_PeptidylDAlanineracemizationviapeptidylLSerine',s("The","dehydration","of","peptidyl-serine",",","followed","by","hydrogenation","to","produce","peptidyl-D-alanine","."),4232726). assertion_content_comment('oboGo_PeptidylDehydroalaninebiosyntheticprocessfrompeptidylTyrosineorpeptidylSerine',s("The","formation","of","peptidyl-dehydroalanine","from","either","peptidyl-tyrosine","by","phenyl","transfer",",","or","from","peptidyl-serine",",","which","is","coupled","with","the","formation","of","5-imidazolinone","by","the","two","neighboring","residues",",","produces","an","4-methylidene-imidazole-5-one","active","site","of","some","amino","acid","ammonia-lyases",";","the","4-methylidene-imidazole-5-one",",","is","formed","autocatalytically","by","cyclization","and","dehydration","of","the","sequence","ASG","."),4280191). assertion_content_comment('oboGo_PeptidylDipeptidaseaactivity',s("OBSOLETE",".","Catalysis","of","the","release","of","a","C-terminal","dipeptide",",","Xaa-Xbb","from","oligopeptide-Xaa-Xbb",",","when","Xaa","is","not","Pro",",","and","Xbb","is","neither","Asp","nor","Glu",".","Converts","angiotensin","I","to","angiotensin","II","."),4210172). assertion_content_comment('oboGo_PeptidylDipeptidaseactivity',s("Catalysis","of","the","release","of","C-terminal","dipeptides","from","a","polypeptide","chain","."),4210169). assertion_content_comment('oboGo_PeptidylDipeptidasedcpactivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","unblocked",",","C-terminal","dipeptides","from","oligopeptides",",","with","broad","specificity",".","Does","not","hydrolyze","bonds","in","which","P1","'","is","Pro",",","or","both","P1","and","P1","'","are","Gly","."),4247710). assertion_content_comment('oboGo_PeptidylDipeptidaseinhibitoractivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","peptidyl-dipeptidase",".","Peptidyl-dipeptidase","activity","catalyzes","the","release","of","C-terminal","dipeptides","from","a","polypeptide","chain","."),4160615). assertion_content_comment('oboGo_PeptidylDiphthamidebiosyntheticprocessfrompeptidylHistidine',s("The","modification","of","peptidyl-histidine","to","2","'","-","(","3-carboxamido-3-","(","trimethylammonio",")","propyl",")","-L-histidine",",","known","as","diphthamide",",","found","in","translation","elongation","factor","eEF-2","."),4258412). assertion_content_comment('oboGo_PeptidylDiphthamidecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","peptidyl-diphthamide",",","a","modified","histidine","residue","."),4258363). assertion_content_comment('oboGo_PeptidylDiphthamidemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","peptidyl-diphthamide",",","a","modified","histidine","residue","."),4258359). assertion_content_comment('oboGo_PeptidylDiphthinebiosyntheticprocessfrompeptidylHistidine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptidyl-diphthine","from","other","compounds",",","including","peptidyl-histidine","."),4258440). assertion_content_comment('oboGo_PeptidylDiphthinecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","peptidyl-diphthine",",","a","modified","histidine","residue","."),4258426). assertion_content_comment('oboGo_PeptidylDiphthinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","peptidyl-diphthine",",","a","modified","histidine","residue","."),4258293). assertion_content_comment('oboGo_PeptidylGlutamicacidcarboxylation',s("The","gamma-carboxylation","of","peptidyl-glutamic","acid",";","catalyzed","by","the","vitamin","K","dependent","gamma-glutamyl","carboxylase","."),4258341). assertion_content_comment('oboGo_PeptidylGlutamicacidesterification',s("The","addition","of","an","ester","group","to","a","glutamic","acid","residue","in","a","protein","."),4245088). assertion_content_comment('oboGo_PeptidylGlutamicacidmethylation',s("The","addition","of","a","methyl","group","to","a","glutamic","acid","residue","in","a","protein","."),4283111). assertion_content_comment('oboGo_PeptidylGlutamicacidmodification',s("The","modification","of","peptidyl-glutamic","acid","."),4232994). assertion_content_comment('oboGo_PeptidylGlutamicacidpolyAdpRibosylation',s("This","modification","produces","peptidyl-glutamic","acid","poly-ADP-ribose","found","in","a","number","of","nuclear","proteins","under","certain","conditions","including","the","repair","of","single","strand","DNA","breaks",".","The","activated","form","of","the","generating","enzyme","poly","(","ADP-ribose",")","polymerase","is","itself","modified","in","this","way","."),4281867). assertion_content_comment('oboGo_PeptidylGlutaminaseactivity',s("Catalysis","of","the","reaction",":","alpha-N-peptidyl-L-glutamine","+","H2O","=","alpha-N-peptidyl-L-glutamate","+","NH3","."),4271081). assertion_content_comment('oboGo_PeptidylGlutamine2Methylation',s("The","methylation","of","glutamine","to","form","2-methyl-L-glutamine","."),4282036). assertion_content_comment('oboGo_PeptidylGlutamineesterification',s("The","addition","of","an","ester","group","to","a","glutamine","residue","in","a","protein","."),4245122). assertion_content_comment('oboGo_PeptidylGlutaminemethylation',s("The","addition","of","a","methyl","group","to","a","glutamine","residue","in","a","protein","."),4282026). assertion_content_comment('oboGo_PeptidylGlutaminemodification',s("The","modification","of","peptidyl-glutamine","."),4245065). assertion_content_comment('oboGo_PeptidylGlutamylpeptidehydrolyzingenzymeactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","bonds","after","acidic","amino","acids","and","after","branched","chain","amino","acids","."),4300654). assertion_content_comment('oboGo_PeptidylGlycinamidaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","H2O","+","peptidyl-glycinamide","=","glycinamide","+","peptide",".","Cleavage","of","C-terminal","glycinamide","from","a","polypeptide","."),4266856). assertion_content_comment('oboGo_PeptidylGlycinecholesterylesterbiosynthesisfrompeptidylGlycine',s("The","synthesis","of","peptidyl-glycine","cholest-5-en-3-beta-ol","ester","at","the","carboxy-terminus","of","autolytically","cleaved","proteins","."),4244978). assertion_content_comment('oboGo_PeptidylGlycinemodification',s("The","modification","of","peptidyl-glycine","."),4040441). assertion_content_comment('oboGo_PeptidylGlycylPhosphatidylethanolaminebiosyntheticprocessfrompeptidylGlycine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","C-terminal","peptidyl-glycine","ethanolamide-linked","phosphatide","following","hydrolysis","of","a","glycyl-peptide","bond",",","as","in","the","cleavage","of","arginine","from","the","carboxy-terminal","of","Apg8","followed","by","its","amidation","with","phosphatidylethanolamine","."),4266424). assertion_content_comment('oboGo_PeptidylHistidineadenylylation',s("The","adenylylation","of","peptidyl-histidine","to","form","peptidyl-1","'","-","(","phospho-5","'","-adenosine",")","-L-histidine","(","otherwise","known","as","tau-AMP-histidine",",","tele-AMP-histidine",")","or","peptidyl-3","'","-","(","phospho-5","'","-adenosine",")","-L-histidine","(","otherwise","known","as","pi-AMP-histidine",",","pros-AMP-histidine",")"),4287287). assertion_content_comment('oboGo_Peptidyl_HistidineAdenylylationToFormPeptidyl_1_Phospho_5_Adenosine_L_Histidine',s("The","adenylylation","of","peptidyl-histidine","to","form","peptidyl-1","'","-","(","phospho-5","'","-adenosine",")","-L-histidine","(","otherwise","known","as","tau-AMP-histidine",",","tele-AMP-histidine",")"),4287289). assertion_content_comment('oboGo_PeptidylHistidinebromination',s("The","bromination","of","peptidyl-histidine","to","form","peptidyl-L-bromohistidine",";","the","position","of","the","bromine","substitution","is","unknown","."),4284138). assertion_content_comment('oboGo_PeptidylHistidinemethylation',s("The","methylation","of","peptidyl-L-histidine","to","form","peptidyl-L-1","'","-methyl-L-histidine","(","otherwise","known","as","tau-methylhistidine",",","tele-methylhistidine",")","or","peptidyl-L-3","'","-methyl-L-histidine","(","otherwise","known","as","pi-methylhistidine",",","pros-methylhistidine",")"),4283101). assertion_content_comment('oboGo_PeptidylHistidinemethylationtoformprosMethylhistidine',s("The","methylation","of","peptidyl-L-histidine","to","form","peptidyl-L-3","'","-methyl-L-histidine","(","otherwise","known","as","pi-methylhistidine",",","pros-methylhistidine",")"),4306354). assertion_content_comment('oboGo_PeptidylHistidinemethylationtoformteleMethylhistidine',s("The","methylation","of","peptidyl-L-histidine","to","form","peptidyl-L-1","'","-methyl-L-histidine","(","otherwise","known","as","tau-methylhistidine",",","tele-methylhistidine",")"),4306408). assertion_content_comment('oboGo_PeptidylHistidinemodification',s("The","modification","of","peptidyl-histidine","."),4245000). assertion_content_comment('oboGo_PeptidylHistidinephosphorylation',s("The","phosphorylation","of","peptidyl-histidine","to","form","peptidyl-1","'","-phospho-L-histidine","(","otherwise","known","as","tau-phosphohistidine",",","tele-phosphohistidine",")","or","peptidyl-3","'","-phospho-L-histidine","(","otherwise","known","as","pi-phosphohistidine",",","pros-phosphohistidine",")"),4279542). assertion_content_comment('oboGo_PeptidylHistidineuridylylation',s("The","uridylylation","of","peptidyl-histidine","to","form","peptidyl-1","'","-","(","phospho-5","'","-uridine",")","-L-histidine","(","otherwise","known","as","tau-UMP-histidine",",","tele-UMP-histidine",")","or","peptidyl-3","'","-","(","phospho-5","'","-uridine",")","-L-histidine","(","otherwise","known","as","pi-UMP-histidine",",","pros-UMP-histidine",")"),4287255). assertion_content_comment('oboGo_Peptidyl_HistidineUridylylationToFormPeptidyl_1_Phospho_5_Uridine_L_Histidine',s("The","uridylylation","of","peptidyl-histidine","to","form","peptidyl-1","'","-","(","phospho-5","'","-uridine",")","-L-histidine","(","otherwise","known","as","tau-UMP-histidine",",","tele-UMP-histidine",")"),4287257). assertion_content_comment('oboGo_PeptidylIsoleucinemodification',s("The","modification","of","peptidyl-isoleucine","."),4258186). assertion_content_comment('oboGo_PeptidylIsoleucineracemization',s("The","racemization","of","peptidyl-isoleucine","."),4237201). assertion_content_comment('oboGo_Peptidyl_L_245_TopaquinoneBiosyntheticProcessFromPeptidyl_Tyrosine',s("The","modification","of","protein","tyrosine","to","L-2","'",",","4","'",",","5","'","-topaquinone",",","characteristic","of","the","active","site","of","copper","amine","oxidases","."),4284250). assertion_content_comment('oboGo_Peptidyl_L_345_TrihydroxyphenylalanineBiosyntheticProcessFromPeptidyl_Tyrosine',s("The","modification","of","protein","tyrosine","to","peptidyl-L-3","'",",","4","'",",","5","'","-dihydroxyphenylalanine","."),4284475). assertion_content_comment('oboGo_Peptidyl_L_34_DihydroxyphenylalanineBiosyntheticProcessFromPeptidyl_Tyrosine',s("The","modification","of","protein","tyrosine","to","peptidyl-L-3","'",",","4","'","-dihydroxyphenylalanine","(","DOPA",")"),4284280). assertion_content_comment('oboGo_Peptidyl_L_3_OxoalanineBiosyntheticProcessFromPeptidyl_CysteineOrPeptidyl_Serine',s("The","modification","of","peptidyl-cysteine","or","peptidyl-serine","to","peptidyl-L-3-oxoalanine",";","characteristic","of","the","active","sites","of","arylsulfatases","."),4284362). assertion_content_comment('oboGo_Peptidyl_L_3_PhenyllacticAcidBiosyntheticProcessFromPeptidyl_Phenylalanine',s("The","modification","of","a","N-terminal","peptidyl-phenylalanine","residue","by","either","oxidative","deamination","or","by","transamination","and","subsequent","reduction","to","form","peptidyl-L-3-phenyllactic","acid","."),4284216). assertion_content_comment('oboGo_PeptidylLacticacidbiosyntheticprocessfrompeptidylSerine',s("The","modification","of","N-terminal","peptidyl-serine","to","lactic","acid","."),4284388). assertion_content_comment('oboGo_PeptidylLAminoacidracemization',s("The","process","of","conversion","of","a","L-amino","acid","into","its","enantiomer",",","the","corresponding","D-amino","acid","."),4232710). assertion_content_comment('oboGo_PeptidylLBetaMethylthioasparaginebiosyntheticprocessfrompeptidylAsparagine',s("The","modification","of","peptidyl-asparagine","to","form","peptidyl-L-beta-methylthioasparagine",",","typical","of","bacterial","ribosomal","protein","S12","."),4314594). assertion_content_comment('oboGo_PeptidylLBetaMethylthioasparticacidbiosyntheticprocessfrompeptidylAsparticacid',s("The","modification","of","peptidyl-aspartic","acid","to","form","peptidyl-L-beta-methylthioaspartic","acid",",","typical","of","bacterial","ribosomal","protein","S12","."),4279646). assertion_content_comment('oboGo_PeptidylLCysteineglutathionedisulfidebiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","peptidyl-cysteine","by","covalent","addition","of","glutathione","to","form","peptidyl-L-cysteine","glutathione","disulfide","."),4285052). assertion_content_comment('oboGo_PeptidylLCysteinemethyldisulfidebiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","peptidyl-cysteine","to","form","peptidyl-L-cysteine","methyl","disulfide","."),4280045). assertion_content_comment('oboGo_PeptidylLCysteinemethylesterbiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","peptidyl-cysteine","to","form","peptidyl-L-cysteine","methyl","ester","."),4280111). assertion_content_comment('oboGo_PeptidylLCysteinesPalmitoylation',s("The","covalent","attachment","of","a","palmitoyl","group","to","a","sulfur","(","S",")","atom","within","a","cysteine","residue","to","form","peptidyl-S-palmitoyl-L-cysteine","."),4279954). assertion_content_comment('oboGo_PeptidylLeucineesterification',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptidyl-L-leucine","methyl","ester","."),4281916). assertion_content_comment('oboGo_PeptidylLeucinemodification',s("The","modification","of","peptidyl-leucine","."),4283228). assertion_content_comment('oboGo_PeptidylLeucineracemization',s("The","racemization","of","peptidyl-leucine","."),4237278). assertion_content_comment('oboGo_PeptidylLGlutamicacid5Methylesterbiosyntheticprocessfromglutamicacid',s("The","methyl","esterification","of","peptidyl-glutamic","acid","."),4245095). assertion_content_comment('oboGo_PeptidylLGlutamicacid5Methylesterbiosyntheticprocessfromglutamine',s("The","coupled","methyl","esterification","and","deamidation","of","peptidyl-glutamine","."),4245134). assertion_content_comment('oboGo_PeptidylLGlutamicacid5MethylesterbiosyntheticprocessfrompeptidylGlutamicacidorpeptidylGlutamine',s("The","methyl","esterification","of","peptidyl-glutamic","acid","or","peptidyl-glutamine","to","form","the","derivative","glutamic","acid","5-methyl","ester","."),4245090). assertion_content_comment('oboGo_PeptidylLGlutamyl5GlycerylphosphorylethanolaminebiosyntheticprocessfrompeptidylGlutamicacid',s("The","modification","of","peptidyl-glutamic","acid","residues","by","the","covalent","attachment","of","ethanolamine",",","itself","further","modified","by","the","addition","of","a","phosphoglycerol","unit","."),4284148). assertion_content_comment('oboGo_PeptidylLGlutamyl5OmegaHydroxyceramideesterbiosyntheticprocessfrompeptidylGlutamine',s("The","modification","of","peptidyl-glutamine","residues","by","deamidation","and","esterification","with","omega-hydroxyceramide","."),4266437). assertion_content_comment('oboGo_PeptidylLysine5Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","protein","L-lysine","+","2-oxoglutarate","+","O2","=","protein","5-hydroxy-L-lysine","+","succinate","+","CO2","."),4179066). assertion_content_comment('oboGo_PeptidylLysineacetylation',s("The","acetylation","of","peptidyl-lysine","."),4072858). assertion_content_comment('oboGo_PeptidylLysineadenylylation',s("The","adenylylation","of","peptidyl-lysine","to","form","peptidyl-N6-","(","phospho-5","'","-adenosine",")","-L-lysine","."),4279476). assertion_content_comment('oboGo_PeptidylLysinebiotinylation',s("The","covalent","modification","of","peptidyl-lysine","by","biotin","to","form","peptidyl-N6-biotinyl-L-lysine","."),4283122). assertion_content_comment('oboGo_PeptidylLysinecarboxyethylation',s("The","modification","of","peptidyl-lysine","to","form","peptidyl-N6-1-carboxyethyl-L-lysine","."),4280001). assertion_content_comment('oboGo_PeptidylLysinecarboxylation',s("The","modification","of","peptidyl-lysine","to","form","peptidyl-N6-carboxy-L-lysine","."),4279929). assertion_content_comment('oboGo_PeptidylLysinedeacetylation',s("The","removal","of","an","acetyl","group","from","an","acetylated","lysine","residue","in","a","peptide","or","protein","."),4348528). assertion_content_comment('oboGo_PeptidylLysinedihydroxylationto45DihydroxyLLysine',s("The","dihydroxylation","of","peptidyl-lysine","to","peptidyl-4",",","5-dihydroxy-L-lysine","."),4307340). assertion_content_comment('oboGo_PeptidylLysinedimethylation',s("The","methylation","of","peptidyl-lysine","to","form","peptidyl-N6",",","N6-dimethyl-L-lysine","."),4283018). assertion_content_comment('oboGo_PeptidylLysineesterification',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptidyl-L-lysine","methyl","ester","."),4306343). assertion_content_comment('oboGo_PeptidylLysineformylation',s("The","modification","of","peptidyl-lysine","to","form","peptidyl-N6-formyl-L-lysine","."),4280266). assertion_content_comment('oboGo_PeptidylLysineguanylylation',s("The","guanylylation","of","peptidyl-lysine","to","form","peptidyl-N6-","(","phospho-5","'","-guanosine",")","-L-lysine","."),4279790). assertion_content_comment('oboGo_PeptidylLysinehydroxylation',s("The","hydroxylation","of","peptidyl-lysine","to","form","peptidyl-hydroxylysine","."),4258377). assertion_content_comment('oboGo_PeptidylLysinehydroxylationto4HydroxyLLysine',s("The","hydroxylation","of","peptidyl-lysine","to","peptidyl-4-hydroxy-L-lysine","."),4282763). assertion_content_comment('oboGo_PeptidylLysinehydroxylationto5HydroxyLLysine',s("The","hydroxylation","of","peptidyl-lysine","to","peptidyl-5-hydroxy-L-lysine","."),4282743). assertion_content_comment('oboGo_PeptidylLysinelipoylation',s("The","lipoylation","of","peptidyl-lysine","to","form","peptidyl-N6-lipoyl-L-lysine","."),4283144). assertion_content_comment('oboGo_PeptidylLysinemethylation',s("The","methylation","of","peptidyl-lysine","to","form","either","the","mono-",",","di-","or","trimethylated","derivative","."),4274486). assertion_content_comment('oboGo_PeptidylLysinemodification',s("The","modification","of","peptidyl-lysine","."),4040452). assertion_content_comment('oboGo_PeptidylLysinemodificationtohypusine',s("The","modification","of","peptidyl-lysine","to","form","hypusine",",","N6-","(","4-amino-2-hydroxybutyl",")","-L-lysine","."),4210928). assertion_content_comment('oboGo_PeptidylLysinemodificationtopeptidylN6Pyruvicacid2IminylLLysine',s("The","modification","of","peptidyl-lysine","to","form","peptidyl-N6-pyruvic","acid","2-iminyl-L-lysine","."),4282312). assertion_content_comment('oboGo_PeptidylLysinemonomethylation',s("The","methylation","of","peptidyl-lysine","to","form","peptidyl-N6-methyl-L-lysine","."),4283028). assertion_content_comment('oboGo_PeptidylLysinemyristoylation',s("The","myristoylation","of","peptidyl-lysine","to","form","peptidyl-N6-myristoyl-L-lysine","."),4283007). assertion_content_comment('oboGo_PeptidylLysinen6Acetylation',s("The","acetylation","of","the","peptidyl-lysine","of","proteins","to","form","the","derivative","peptidyl-N6-acetyl-L-lysine",";","catalyzed","by","tubulin","N-acetyltransferase","."),4283654). assertion_content_comment('oboGo_PeptidylLysinen6Myristoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","myristoyl","group","to","the","N6","nitrogen","atom","on","a","lysine","residue","of","a","peptide","or","protein","molecule","."),4282986). assertion_content_comment('oboGo_PeptidylLysinen6Palmitoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","palmitoyl","group","to","the","N6","nitrogen","atom","on","a","lysine","residue","of","a","peptide","or","protein","molecule","."),4282966). assertion_content_comment('oboGo_PeptidylLysineoxidation',s("The","oxidation","of","the","terminal","amino-methylene","groups","of","peptidyl-L-lysine","or","peptidyl-5-hydroxy-L-lysine","to","aldehyde","groups","to","form","allysine","or","hydroxyallysine","residues",",","respectively",";","these","are","intermediates","in","the","formation","of","covalent","cross-links","between","adjacent","polypeptide","chains","in","proteins","such","as","collagens","."),4283155). assertion_content_comment('oboGo_PeptidylLysinepalmitoylation',s("The","palmitoylation","of","peptidyl-lysine","to","form","peptidyl-N6-palmitoyl-L-lysine","."),4282996). assertion_content_comment('oboGo_PeptidylLysinetrimethylation',s("The","methylation","of","peptidyl-lysine","to","form","peptidyl-N6",",","N6",",","N6-trimethyl-L-lysine","."),4283090). assertion_content_comment('oboGo_PeptidylMethioninemodification',s("The","modification","of","peptidyl-methionine","."),4258121). assertion_content_comment('oboGo_PeptidylMethionineoxidation',s("The","oxidation","of","peptidyl-L-methionine","to","peptidyl-L-methionine","sulfone","."),4284712). assertion_content_comment('oboGo_PeptidylMethionineracemization',s("The","racemization","of","peptidyl-methionine","."),4237266). assertion_content_comment('oboGo_PeptidylN4HydroxymethylLAsparaginebiosyntheticprocessfrompeptidylAsparagine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","N4-hydroxymethyl-L-asparagine","from","other","compounds",",","including","peptidyl-asparagine","."),4279419). assertion_content_comment('oboGo_Peptidyl_N6N6N6_Trimethyl_LysineHydroxylationToPeptidyl_N6N6N6_Trimethyl_5_Hydroxy_L_Lysine',s("The","hydroxylation","of","peptidyl-N6",",","N6",",","N6-trimethyl-L-lysine","to","form","peptidyl-N6",",","N6",",","N6-trimethyl-5-hydroxy-L-lysine","."),4274667). assertion_content_comment('oboGo_Peptidyl_O_Sn_1_Glycerophosphoryl_L_SerineBiosyntheticProcessFromPeptidyl_Serine',s("The","modification","of","peptidyl-serine","to","peptidyl-O-","(","sn-1-glycerophosphoryl",")","-L-serine","."),4282327). assertion_content_comment('oboGo_PeptidylOxazolinedehydrogenaseactivity',s("Catalysis","of","the","reduction","of","a","peptide-linked","oxazoline","to","oxazole","."),4284969). assertion_content_comment('oboGo_PeptidylPhenylalaninebromination',s("The","bromination","of","phenylalanine","."),4282721). assertion_content_comment('oboGo_Peptidyl_PhenylalanineBrominationToL_2_Bromophenylalanine',s("The","bromination","of","peptidyl-phenylalanine","to","form","L-2","'","-bromophenylalanine","."),4282753). assertion_content_comment('oboGo_Peptidyl_PhenylalanineBrominationToL_3_Bromophenylalanine',s("The","bromination","of","peptidyl-phenylalanine","to","form","L-3","'","-bromophenylalanine","."),4282733). assertion_content_comment('oboGo_Peptidyl_PhenylalanineBrominationToL_4_Bromophenylalanine',s("The","bromination","of","peptidyl-phenylalanine","to","form","L-4","'","-bromophenylalanine","."),4282723). assertion_content_comment('oboGo_PeptidylPhenylalaninemodification',s("The","modification","of","peptidyl-phenylalanine","."),4282719). assertion_content_comment('oboGo_PeptidylPhenylalanineracemization',s("The","racemization","of","peptidyl-phenylalanine","."),4237189). assertion_content_comment('oboGo_PeptidylProline3Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","peptidyl","L-proline","+","2-oxoglutarate","+","O2","=","peptidyl","trans-3-hydroxy-L-proline","+","succinate","+","CO2","."),4234324). assertion_content_comment('oboGo_PeptidylProline4Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","peptidyl","L-proline","+","2-oxoglutarate","+","O2","=","peptidyl","trans-4-hydroxy-L-proline","+","succinate","+","CO2","."),4203260). assertion_content_comment('oboGo_PeptidylProlinediHydroxylation',s("The","modification","of","peptidyl-proline","to","form","trans-2",",","3-cis-3",",","4-dihydroxy-L-proline","."),4285732). assertion_content_comment('oboGo_PeptidylProlinedioxygenaseactivity',s("Catalysis","of","the","transfer","of","a","hydroxyl","group","from","2-oxoglutarate","to","a","prolyl","residue","in","a","protein","."),4203248). assertion_content_comment('oboGo_PeptidylProlinehydroxylation',s("The","hydroxylation","of","peptidyl-proline","to","form","peptidyl-hydroxyproline","."),4242331). assertion_content_comment('oboGo_PeptidylProlinehydroxylationto3HydroxyLProline',s("The","modification","of","peptidyl-proline","to","form","3-hydroxy-L-proline",";","catalyzed","by","procollagen-proline","3-dioxygenase","."),4281359). assertion_content_comment('oboGo_PeptidylProlinehydroxylationto4HydroxyLProline',s("The","modification","of","peptidyl-proline","to","form","4-hydroxy-L-proline",";","catalyzed","by","procollagen-proline",",","2-oxoglutarate-4-dioxygenase","."),4281371). assertion_content_comment('oboGo_PeptidylProlinemodification',s("The","modification","of","peptidyl-proline","."),4125453). assertion_content_comment('oboGo_PeptidylProlylcisTransisomeraseactivity',s("Catalysis","of","the","reaction",":","peptidyl-proline","(","omega","=","180",")","=","peptidyl-proline","(","omega","=","0",")"),4192427). assertion_content_comment('oboGo_PeptidylProlylisomerasebreaction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4223941). assertion_content_comment('oboGo_PeptidylPyroglutamicacidbiosyntheticprocessusingglutaminylPeptidecyclotransferase',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","peptidyl-pyroglutamic","acid",",","catalyzed","by","glutaminyl-peptide","cyclotransferase","."),4258324). assertion_content_comment('oboGo_PeptidylPyrromethanecofactorlinkage',s("The","covalent","binding","of","a","pyrromethane","(","dipyrrin",")","cofactor","to","protein","via","the","sulfur","atom","of","cysteine","forming","dipyrrolylmethanemethyl-L-cysteine","."),4284646). assertion_content_comment('oboGo_Peptidyl_S_12_Hydroxyfarnesyl_L_CysteineBiosyntheticProcessFromPeptidyl_Cysteine',s("The","modification","of","peptidyl-cysteine","to","form","S-12-hydroxyfarnesyl-L-cysteine",";","formation","of","S-farnesycysteine","may","be","coupled","with","subsequent","cleavage","of","a","carboxy-terminal","tripeptide","for","the","CXXX","motif","and","methyl","esterification","of","the","farnesylated","cysteine","."),4280139). assertion_content_comment('oboGo_PeptidylSarcosineincorporation',s("The","incorporation","of","sarcosine","(","N-methylglycine",")","into","non-coded","peptides","."),4244843). assertion_content_comment('oboGo_PeptidylSCarbamoylLCysteinedehydration',s("The","dehydration","of","peptidyl-S-carbamoyl-L-cysteine","to","form","peptidyl-S-cyano-L-cysteine","."),4357251). assertion_content_comment('oboGo_PeptidylSDiacylglycerolLCysteinebiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","peptidyl-cysteine","to","form","peptidyl-S-diacylglycerol-L-cysteine",";","the","oleate","and","palmitate","actually","represent","mixtures","of","saturated","(","generally","at","3","'",")","and","unsaturated","(","generally","at","2","'",")","fatty","acids","."),4279948). assertion_content_comment('oboGo_PeptidylSDiphytanylglyceroldietherLCysteinebiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","cysteine","to","form","peptidyl-S-diphytanylglycerol","diether-L-cysteine","."),4285095). assertion_content_comment('oboGo_PeptidylSelenocysteinemodification',s("The","modification","of","peptidyl-selenocysteine","."),4274508). assertion_content_comment('oboGo_PeptidylSerineacetylation',s("The","acetylation","of","peptidyl-serine","."),4258154). assertion_content_comment('oboGo_PeptidylSerineadpRibosylation',s("The","transfer",",","from","NAD",",","of","ADP-ribose","to","peptidyl-serine","to","form","peptidyl-O-","(","ADP-ribosyl",")","-L-serine","."),4279409). assertion_content_comment('oboGo_PeptidylSerinecyclaseactivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4284988). assertion_content_comment('oboGo_PeptidylSerinedecanoylation',s("The","decanoylation","of","peptidyl-serine","to","form","peptidyl-O3-decanoyl-L-serine",",","typical","of","the","protein","ghrelin","."),4286151). assertion_content_comment('oboGo_PeptidylSerinedephosphorylation',s("The","removal","of","phosphoric","residues","from","peptidyl-O-phospho-L-serine","to","form","peptidyl-serine","."),4174392). assertion_content_comment('oboGo_PeptidylSerinemodification',s("The","modification","of","peptidyl-serine","."),4038979). assertion_content_comment('oboGo_PeptidylSerineoAcetylation',s("The","acetylation","of","peptidyl-serine","to","form","peptidyl-O-acetyl-L-serine","."),4307644). assertion_content_comment('oboGo_PeptidylSerineoctanoylation',s("The","octanoylation","of","peptidyl-serine","to","form","peptidyl-O3-octanoyl-L-serine",",","typical","of","the","protein","ghrelin","."),4285622). assertion_content_comment('oboGo_PeptidylSerineoGlucuronidation',s("The","O-glucuronidation","of","peptidyl-serine","to","form","peptidyl-O3-D-glucuronyl-L-serine","."),4281560). assertion_content_comment('oboGo_PeptidylSerinepalmitoylation',s("The","covalent","attachment","of","a","palmitoyl","group","to","an","oxygen","(","O",")","atom","in","a","serine","residue","to","form","peptidyl-O-palmitoyl-L-serine","."),4280075). assertion_content_comment('oboGo_PeptidylSerinephosphopantetheinylation',s("The","phosphopantetheinylation","of","peptidyl-serine","to","form","peptidyl-O-phosphopantetheine-L-serine","."),4284182). assertion_content_comment('oboGo_PeptidylSerinephosphorylationinvolvedinacrosomereaction',s("The","phosphorylation","of","peptidyl-serine","to","form","peptidyl-O-phospho-L-serine","that","is","part","of","the","acrosome","reaction","."),4117557). assertion_content_comment('oboGo_PeptidylSerinephosphorylation',s("The","phosphorylation","of","peptidyl-serine","to","form","peptidyl-O-phospho-L-serine","."),4065510). assertion_content_comment('oboGo_PeptidylSerineracemization',s("The","racemization","of","peptidyl-serine","."),4237213). assertion_content_comment('oboGo_PeptidylSerinesulfation',s("The","sulfation","of","peptidyl-serine","to","form","peptidyl-O-sulfo-L-serine","."),4272946). assertion_content_comment('oboGo_PeptidylSFarnesylLCysteinebiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","peptidyl-cysteine","to","form","peptidyl-S-farnesyl-L-cysteine",";","formation","of","S-farnesycysteine","may","be","coupled","with","subsequent","cleavage","of","a","carboxy-terminal","tripeptide","for","the","CXXX","motif","and","methyl","esterification","of","the","farnesylated","cysteine",";","the","residue","may","be","found","at","the","first","position","in","the","sequence","motif","C-X-X-","(","SAQCMT",")","*","where","the","second","and","third","positions","are","usually","aliphatic","."),4280125). assertion_content_comment('oboGo_PeptidylSGeranylgeranylLCysteinebiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","peptidyl-cysteine","to","form","peptidyl-S-geranylgeranylcysteine",";","formation","of","S-geranylgeranyl-L-cysteine","may","be","coupled","with","subsequent","cleavage","of","a","carboxy-terminal","tripeptide","for","the","CAAX","motif","and","methyl","esterification","of","the","geranylgeranylated","cysteine",";","methyl","esterification","but","not","cleavage","occurs","for","the","CXC","motif",".","For","the","type","II","geranylgeranyltransferase","the","residue","may","be","found","at","the","first","and","final","positions","in","the","sequence","motif","C-X-C","*","or","at","the","final","position","in","the","sequence","motif","C-C","*","These","motifs","are","necessary","but","not","sufficient","for","modification","."),4280087). assertion_content_comment('oboGo_PeptidylSMyristoylLCysteinebiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","peptidyl-cysteine","to","form","peptidyl-S-myristoyl-L-cysteine","."),4245594). assertion_content_comment('oboGo_PeptidylSPalmitoleylLCysteinebiosyntheticprocessfrompeptidylCysteine',s("The","modification","of","peptidyl-cysteine","to","form","peptidyl-S-palmitoleyl-L-cysteine","specifically","."),4232915). assertion_content_comment('oboGo_PeptidylThiazolinedehydrogenaseactivity',s("Catalysis","of","the","reduction","of","a","peptide-linked","thiazoline","to","thiazole","."),4284948). assertion_content_comment('oboGo_PeptidylThreonineadenylylation',s("The","adenylylation","of","peptidyl-threonine","to","form","peptidyl-O-","(","phospho-5","'","-adenosine",")","-L-threonine","."),4279745). assertion_content_comment('oboGo_PeptidylThreoninedecanoylation',s("The","decanoylation","of","peptidyl-threonine","to","form","peptidyl-O3-decanoyl-L-threonine",",","typical","of","the","protein","ghrelin","."),4286161). assertion_content_comment('oboGo_PeptidylThreoninemodification',s("The","modification","of","peptidyl-threonine","."),4025753). assertion_content_comment('oboGo_PeptidylThreonineoctanoylation',s("The","octanoylation","of","peptidyl-threonine","to","form","peptidyl-O3-octanoyl-L-threonine",",","typical","of","the","protein","ghrelin","."),4286171). assertion_content_comment('oboGo_PeptidylThreoninepalmitoylation',s("The","covalent","attachment","of","a","palmitoyl","group","to","an","oxygen","(","O",")","atom","in","a","threonine","residue","to","form","peptidyl-O-palmitoyl-L-threonine","."),4280062). assertion_content_comment('oboGo_PeptidylThreoninephosphorylation',s("The","phosphorylation","of","peptidyl-threonine","to","form","peptidyl-O-phospho-L-threonine","."),4025755). assertion_content_comment('oboGo_PeptidylThreonineracemization',s("The","racemization","of","peptidyl-L-threo-threonine","at","the","alpha-carbon","to","form","D-allo-threonine",".","This","is","coupled","with","the","formation","of","the","cross-link","2-","(","S-L-cysteinyl",")","-D-allo-threonine","."),4362157). assertion_content_comment('oboGo_PeptidylThreoninesulfation',s("The","sulfation","of","peptidyl-threonine","to","form","peptidyl-O-sulfo-L-threonine","."),4272999). assertion_content_comment('oboGo_PeptidylThyroninebiosyntheticprocessfrompeptidylTyrosine',s("The","formation","of","peptidyl-thyronine","from","peptidyl-tyrosine","in","thyroglobulin","by","phenyl","transfer","coupled","with","the","formation","of","peptidyl-dehydroalanine","."),4234138). assertion_content_comment('oboGo_PeptidylThyronineiodination',s("The","iodination","of","peptidyl-thyronine",",","formed","from","tyrosine","."),4281290). assertion_content_comment('oboGo_PeptidylThyronineiodinationtoform3355TetraiodoLThyronine',s("The","iodination","of","peptidyl-thyronine","to","form","peptidyl-3","'",",","3","'","'",",","5","'",",","5","'","'","-tetraiodo-L-thyronine","(","L-thyroxine",")"),4281303). assertion_content_comment('oboGo_PeptidylThyronineiodinationtoform335TriiodoLThyronine',s("The","iodination","of","peptidyl-thyronine","to","form","peptidyl-3","'",",","3","'","'",",","5","'","-triiodo-L-thyronine","(","triiodothyronine",")"),4281292). assertion_content_comment('oboGo_PeptidylTryptophanbromination',s("The","bromination","of","peptidyl-tryptophan",",","to","form","peptidyl-L-6","'","-bromotryptophan","."),4284351). assertion_content_comment('oboGo_PeptidylTryptophanhydroxylation',s("The","hydroxylation","of","peptidyl-tryptophan",",","to","form","peptidyl-L-3-hydroxytryptophan","."),4298462). assertion_content_comment('oboGo_PeptidylTryptophanmodification',s("The","chemical","alteration","of","a","tryptophan","residue","in","a","peptide","."),4042141). assertion_content_comment('oboGo_PeptidylTryptophanoxidationtotryptophylquinone',s("The","oxidation","of","peptidyl-tryptophan","to","form","tryptophan-6",",","7-dione",",","otherwise","known","as","tryptophyl","quinone",",","which","is","further","modified","by","cross-linking","to","either","tryptophan","or","cysteine","."),4042168). assertion_content_comment('oboGo_PeptidylTryptophanracemization',s("The","racemization","of","peptidyl-tryptophan","."),4237290). assertion_content_comment('oboGo_PeptidylTryptophansuccinylation',s("The","modification","of","an","N-terminal","peptidyl-tryptophan","residue","to","form","peptidyl-N2-succinyl-L-tryptophan","."),4284240). assertion_content_comment('oboGo_PeptidylTyrosineadenylylation',s("The","adenylylation","of","peptidyl-tyrosine","to","form","peptidyl-O4","'","-","(","phospho-5","'","-adenosine",")","-L-tyrosine","."),4280231). assertion_content_comment('oboGo_PeptidylTyrosinedehydrogenation',s("The","oxidation","of","the","C","alpha-C","beta","bond","of","peptidyl-tyrosine","to","form","peptidyl-dehydrotyrosine","coupled","with","cyclization","of","neighboring","residues","."),4280206). assertion_content_comment('oboGo_Peptidyl_TyrosineDehydrogenationToFormE_23_Didehydrotyrosine',s("The","oxidation","of","the","C","alpha-C","beta","bond","of","peptidyl-tyrosine","to","form","peptidyl-","(","E",")","-2",",","3-didehydrotyrosine","coupled","with","cyclization","of","neighboring","residues","."),4307611). assertion_content_comment('oboGo_Peptidyl_TyrosineDehydrogenationToFormZ_23_Didehydrotyrosine',s("The","oxidation","of","the","C","alpha-C","beta","bond","of","peptidyl-tyrosine","to","form","peptidyl-","(","Z",")","-2",",","3-didehydrotyrosine","coupled","with","cyclization","of","neighboring","residues","."),4307621). assertion_content_comment('oboGo_PeptidylTyrosinedephosphorylation',s("The","removal","of","phosphoric","residues","from","peptidyl-O-phospho-tyrosine","to","form","peptidyl-tyrosine","."),4382852). assertion_content_comment('oboGo_PeptidylTyrosinehydroxylation',s("The","hydroxylation","of","peptidyl-tyrosine","to","form","peptidyl-dihydroxyphenylalanine","."),4279693). assertion_content_comment('oboGo_PeptidylTyrosinemodification',s("The","modification","of","peptidyl-tyrosine","."),4016686). assertion_content_comment('oboGo_PeptidylTyrosinephosphorylation',s("The","phosphorylation","of","peptidyl-tyrosine","to","form","peptidyl-O4","'","-phospho-L-tyrosine","."),4016688). assertion_content_comment('oboGo_PeptidylTyrosinesulfation',s("The","sulfation","of","peptidyl-tyrosine","residues","to","form","peptidyl-O4","'","-sulfo-L-tyrosine","."),4223929). assertion_content_comment('oboGo_PeptidylTyrosineuridylylation',s("The","uridylylation","of","peptidyl-tyrosine","to","form","peptidyl-O4","'","-","(","phospho-5","'","-uridine",")","-L-tyrosine",",","found","in","glutamine","synthetase","."),4284489). assertion_content_comment('oboGo_PeptidylValinemodification',s("The","modification","of","peptidyl-valine","."),4282857). assertion_content_comment('oboGo_PeptidylZDehydrobutyrinebiosyntheticprocessfrompeptidylThreonine',s("The","formation","of","(","Z",")","-dehydrobutyrine","by","the","dehydration","of","peptidyl-threonine","."),4284375). assertion_content_comment('oboGo_PerillicAcid_CoALigaseADPFormingactivity',s("Catalysis","of","the","reaction",":","perillic","acid","+","CoA-SH","+","ATP","=","H2O","+","ADP","+","phosphate","+","perillyl-CoA","."),4191418). assertion_content_comment('oboGo_PerillicAcid_CoALigaseAMPFormingactivity',s("Catalysis","of","the","reaction",":","perillic","acid","+","CoA-SH","+","ATP","=","H2O","+","AMP","+","diphosphate","+","perillyl-CoA","."),4191482). assertion_content_comment('oboGo_PerillylAlcoholdehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NAD","(","+",")","+","perillyl","alcohol","=","H","(","+",")","+","NADH","+","perillyl","aldehyde","."),4281786). assertion_content_comment('oboGo_PerillylCoahydrataseactivity',s("Catalysis","of","the","reaction",":","perillyl-CoA","+","H2O","=","2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA","."),4348741). assertion_content_comment('oboGo_PerillylCoasynthetaseactivity',s("Catalysis","of","the","reaction",":","perillic","acid","+","CoA-SH","+","ATP","=","H2O","+","ADP/AMP","+","mono/diphosphate","+","perillyl-CoA","."),4273751). assertion_content_comment('oboGo_PeripheralNervousSystemNonMyelinatedaxonensheathment',s("The","process","in","which","a","non-myelinating","Schwann","cell","membrane","encircles","an","axon","in","the","peripheral","nervous","system",".","A","single","non-myelinating","Schwann","cell","will","typically","associate","with","multiple","axons","."),4329880). assertion_content_comment('oboGo_PeroxidaseHemelinkage',s("The","covalent","linkage","of","heme","to","peroxidase","."),4282009). assertion_content_comment('oboGo_PeroxidaseHemelinkageviadihydroxyhemeLAspartylesterLGlutamylesterLMethioninesulfonium',s("The","covalent","linkage","of","heme","to","peroxidase","via","dihydroxyheme-L-aspartyl","ester-L-glutamyl","ester-L-methionine","sulfonium","."),4282014). assertion_content_comment('oboGo_PeroxidaseHemelinkageviadihydroxyhemeLAspartylesterLGlutamylester',s("The","covalent","linkage","of","heme","to","peroxidase","via","dihydroxyheme-L-aspartyl","ester-L-glutamyl","ester","."),4282048). assertion_content_comment('oboGo_PeroxisomalFattyAcylCoatransporteractivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","fatty","acyl","CoA","(","cis",")","=","ADP","+","phosphate","+","fatty","acyl","CoA","(","trans",")","The","transport","of","fatty","acyl","CoA","into","and","out","of","peroxisomes","."),4216192). assertion_content_comment('oboGo_PeroxisomalLongChainfattyacidimport',s("The","directed","movement","of","long-chain","fatty","acids","into","a","peroxisome","."),4294373). assertion_content_comment('oboGo_PeroxisomeAssemblyatpaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",".","ATP","hydrolysis","to","import","and","assemble","peroxisome","components","into","the","organelle","."),4252569). assertion_content_comment('oboGo_PeroxisomeMatrixTargetingSignal_1Binding',s("Interacting","selectively","and","non-covalently","with","a","type","1","peroxisome","targeting","signal",",","a","tripeptide","with","the","consensus","sequence","(","S/A/C",")","-","(","K/R/H",")","-L","."),4214945). assertion_content_comment('oboGo_PeroxisomeMatrixTargetingSignal_2Binding',s("Interacting","selectively","and","non-covalently","with","a","type","2","peroxisome","targeting","signal",",","a","nonapeptide","with","a","broad","consensus","sequence","of","(","R/K",")","-","(","L/V/I",")","-","(","XXXXX",")","-","(","H/Q",")","-","(","L/A/F",")"),4214919). assertion_content_comment('oboGo_PhagosomeLysosomedockinginvolvedinapoptoticcellclearance',s("The","initial","attachment","of","a","phagosome","membrane","to","a","lysosome","membrane","that","occurs","as","a","part","of","apoptotic","cell","clearance",".","Docking","requires","only","that","the","proteins","come","close","enough","to","interact","and","adhere","."),4151188). assertion_content_comment('oboGo_PhagosomeLysosomedocking',s("The","initial","attachment","of","a","phagosome","membrane","to","a","lysosome","membrane",".","Docking","requires","only","that","the","proteins","come","close","enough","to","interact","and","adhere","."),4151184). assertion_content_comment('oboGo_PhagosomeLysosomefusioninvolvedinapoptoticcellclearance',s("The","creation","of","a","phagolysosome","from","a","phagosome","and","a","lysosome","as","a","part","of","apoptotic","cell","clearance","."),4151167). assertion_content_comment('oboGo_PhagosomeLysosomefusion',s("The","creation","of","a","phagolysosome","from","a","phagosome","and","a","lysosome","."),4151164). assertion_content_comment('oboGo_Phenanthrene_12_EpoxideHydrolaseActivity',s("Catalysis","of","the","reaction",":","phenanthrene-1",",","2-oxide","+","H2O","=","trans-1",",","2-dihydrodiolphenanthrene","."),4274958). assertion_content_comment('oboGo_Phenanthrene12Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","phenanthrene","+","O2","+","NADH","+","H","+","=","H2O","+","NAD","+","+","phenanthrene-1",",","2-oxide","."),4276249). assertion_content_comment('oboGo_Phenanthrene_34_EpoxideHydrolaseActivity',s("Catalysis","of","the","reaction",":","phenanthrene-3",",","4-oxide","+","H2O","=","trans-3",",","4-dihydrodiolphenanthrene","."),4274967). assertion_content_comment('oboGo_Phenanthrene34Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","phenanthrene","+","O2","+","NADH","+","H","+","=","H2O","+","NAD","+","+","phenanthrene-3",",","4-oxide","."),4276139). assertion_content_comment('oboGo_Phenanthrene_45_DicarboxylateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","phenanthrene-4",",","5-dicarboxylate","+","H","+","=","phenanthrene-4-carboxylate","+","CO2","."),4350304). assertion_content_comment('oboGo_Phenanthrene_4_CarboxylateDioxygenaseActivity',s("Catalysis","of","the","reaction",":","phenanthrene-4-carboxylate","+","2","H","+","+","2","e-","+","O2","=","cis-3",",","4-phenanthrenedihydrodiol-4-carboxylate","."),4348887). assertion_content_comment('oboGo_Phenanthrene_910_EpoxideHydrolase9R10R_FormingActivity',s("Catalysis","of","the","reaction",":","phenanthrene-9",",","10-oxide","+","H2O","=","trans-9R",",","10R-dihydrodiolphenanthrene","."),4274996). assertion_content_comment('oboGo_Phenanthrene_910_EpoxideHydrolase9S10S_FormingActivity',s("Catalysis","of","the","reaction",":","phenanthrene-9",",","10-oxide","+","H2O","=","trans-9","(","S",")",",","10","(","S",")","-dihydrodiolphenanthrene","."),4273244). assertion_content_comment('oboGo_Phenanthrene_910_EpoxideHydrolaseActivity',s("Catalysis","of","the","reaction",":","phenanthrene-9",",","10-oxide","+","H2O","=","trans-9",",","10-dihydrodiolphenanthrene","."),4237168). assertion_content_comment('oboGo_Phenanthrene910Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","phenanthrene","+","O2","+","NADH","+","H","+","=","H2O","+","NAD","+","+","phenanthrene-9",",","10-oxide","."),4275941). assertion_content_comment('oboGo_PhenanthreneCatabolicProcessViaTrans_9R10R_Dihydrodiolphenanthrene',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenanthrene",",","a","tricyclic","aromatic","hydrocarbon",",","where","trans-9","(","R",")",",","10","(","R",")","-dihydrodiolphenanthrene","is","the","principal","intermediate","metabolite","."),4272791). assertion_content_comment('oboGo_PhenanthreneCatabolicProcessViaTrans_9S10S_Dihydrodiolphenanthrene',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","phenanthrene",",","a","tricyclic","aromatic","hydrocarbon",",","where","trans-9","(","S",")",",","10","(","S",")","-dihydrodiolphenanthrene","is","the","principal","intermediate","metabolite","."),4272779). assertion_content_comment('oboGo_PhenanthreneEpoxidehydrolaseactivity',s("Catalysis","of","the","reaction",":","a","phenanthrene","dioxide","+","H2O","=","a","dihydrodiolphenanthrene","."),4237166). assertion_content_comment('oboGo_Phenol2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","phenol","+","NADPH","+","H","+","+","O2","=","catechol","+","NADP","+","+","H2O","."),4276517). assertion_content_comment('oboGo_PhenolBetaGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","a","phenol","=","UDP","+","an","aryl","beta-D-glucoside","."),4271094). assertion_content_comment('oboGo_PhenolContainingcompoundbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","phenol",",","any","compound","containing","one","or","more","hydroxyl","groups","directly","attached","to","an","aromatic","carbon","ring","."),4074299). assertion_content_comment('oboGo_PhenolContainingcompoundcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","phenol",",","any","compound","containing","one","or","more","hydroxyl","groups","directly","attached","to","an","aromatic","carbon","ring","."),4158871). assertion_content_comment('oboGo_PhenolContainingcompoundmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","a","phenol",",","any","compound","containing","one","or","more","hydroxyl","groups","directly","attached","to","an","aromatic","carbon","ring","."),3991999). assertion_content_comment('oboGo_PhenolOMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","phenol","=","S-adenosyl-L-homocysteine","+","anisole","+","H","(","+",")"),4308894). assertion_content_comment('oboGo_PhenylacetateCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","CoA","+","phenylacetate","=","AMP","+","diphosphate","+","H","(","+",")","+","phenylacetyl-CoA","."),4369628). assertion_content_comment('oboGo_PhenylacetylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","2","1",",","4-benzoquinone","+","H","(","2",")","O","+","phenylacetyl-CoA","=","2","hydroquinone","+","phenylglyoxylyl-CoA","."),4342279). assertion_content_comment('oboGo_PhenylacetylCoahydrolaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","phenylglyoxylyl-CoA","=","CoA","+","H","(","+",")","+","phenylglyoxylate","."),4343408). assertion_content_comment('oboGo_Phenylalanine2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","L-phenylalanine","+","O","(","2",")","=","2-phenylacetamide","+","CO","(","2",")","+","H","(","2",")","O","."),4271055). assertion_content_comment('oboGo_Phenylalanine4Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","L-phenylalanine","+","tetrahydrobiopterin","+","O2","=","L-tyrosine","+","4-alpha-hydroxytetrahydrobiopterin","."),4205419). assertion_content_comment('oboGo_PhenylalanineAmmoniaLyaseactivity',s("Catalysis","of","the","reaction",":","L-phenylalanine","=","trans-cinnamate","+","NH3","."),4299333). assertion_content_comment('oboGo_PhenylalanineNAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","L-phenylalanine","+","acetyl-CoA","=","N-acetyl-L-phenylalanine","+","CoA","+","H","(","+",")"),4271111). assertion_content_comment('oboGo_PhenylalanineRacemaseATPHydrolyzingactivity',s("Catalysis","of","the","reaction",":","L-phenylalanine","+","ATP","+","H","(","2",")","O","=","D-phenylalanine","+","AMP","+","diphosphate","+","2","H","(","+",")"),4369580). assertion_content_comment('oboGo_PhenylalanineTrnaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","L-phenylalanine","+","tRNA","(","Phe",")","=","AMP","+","diphosphate","+","L-phenylalanyl-tRNA","(","Phe",")"),4199831). assertion_content_comment('oboGo_PhenylalanineTrnaligasecomplex',s("An","enzyme","complex","that","catalyzes","the","ligation","of","phenylalanine","to","tRNA","(","Phe",")",",","forming","L-phenylalanyl-tRNA","(","Phe",")"),4259880). assertion_content_comment('oboGo_PhenylalanylTrnaaminoacylation',s("The","process","of","coupling","phenylalanine","to","phenylalanyl-tRNA",",","catalyzed","by","phenylalanyl-tRNA","synthetase",".","In","tRNA","aminoacylation",",","the","amino","acid","is","first","activated","by","linkage","to","AMP","and","then","transferred","to","either","the","2","'","-","or","the","3","'","-hydroxyl","group","of","the","3","'","-adenosine","residue","of","the","tRNA","."),4179446). assertion_content_comment('oboGo_PhenylethanolamineNMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","phenylethanolamine","=","S-adenosyl-L-homocysteine","+","N-methylphenylethanolamine","."),4203641). assertion_content_comment('oboGo_PheromoneDependentsignaltransductioninvolvedinconjugationwithcellularfusion',s("A","signal","transduction","process","resulting","in","the","relay",",","amplification","or","dampening","of","a","signal","generated","in","response","to","pheromone","exposure","in","organisms","that","undergo","conjugation","with","cellular","fusion",".","An","example","of","this","process","is","found","in","Saccharomyces","cerevisiae","."),3977490). assertion_content_comment('oboGo_PheromoneInducedunidirectionalconjugation',s("The","process","of","unidirectional","(","polarized",")","transfer","of","genetic","information","in","response","to","a","pheromone",".","It","involves","direct","cellular","contact","between","a","donor","and","recipient","cell",";","the","contact","is","followed","by","the","formation","of","a","cellular","bridge","that","physically","connects","the","cells",";","some","or","all","of","the","chromosome","(","s",")","of","one","cell","(","'","male","'",")","is","then","transferred","into","the","other","cell","(","'","female","'",")",";","unidirectional","conjugation","occurs","between","cells","of","different","mating","types","."),3978552). assertion_content_comment('oboGo_PhorbolDiesterhydrolaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","phorbol","12",",","13-dibutanoate","=","butanoate","+","H","(","+",")","+","phorbol","13-butanoate","."),4263091). assertion_content_comment('oboGo_Phosphate_AcylAcylcarrierproteinacyltransferaseactivity',s("Catalysis","of","the","reaction",":","acyl-","[","acyl-carrier","protein","]","+","orthophosphate","=","acyl","phosphate","+","[","acyl-carrier","protein","]"),4327558). assertion_content_comment('oboGo_PhosphateTransmembraneTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","phosphate","(","out",")","=","ADP","+","phosphate","+","phosphate","(","in",")"),4291400). assertion_content_comment('oboGo_PhosphatidateSteroloAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","a","phosphatidate","+","a","sterol","=","a","sterol","ester","+","a","lysophosphatidate","."),4182490). assertion_content_comment('oboGo_Phosphatidylcholine12Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","1-acyl-2-oleoyl-sn-glycero-3-phosphocholine","+","H","(","+",")","+","NADH","+","O","(","2",")","=","1-acyl-2-","[","(","S",")","-12-hydroxyoleoyl","]","-sn-glycero-3-phosphocholine","+","H","(","2",")","O","+","NAD","(","+",")"),4263062). assertion_content_comment('oboGo_PhosphatidylcholineBiosynthesisFromPhosphorylEthanolamineviacdpNMethylethanolamine',s("The","phosphatidylcholine","biosynthetic","process","that","begins","with","an","initial","N-methylation","with","phospho-base","phosphoethanolamine",",","followed","by","two","downstream","N-methylations","on","phosphatidyl-bases",",","phosphatidyl-N-methylethanolamine","and","phosphatidyl-N-dimethylethanolamine",".","The","process","ends","with","the","conversion","of","a","phosphatidyl-N-dimethylethanolamine","to","a","phosphatidylcholine","."),4178827). assertion_content_comment('oboGo_PhosphatidylcholineBiosynthesisFromPhosphorylEthanolaminevianDimethylethanolaminephosphateandcdpCholine',s("The","phosphatidylcholine","biosynthetic","process","that","begins","with","three","consecutive","N-methylation","steps","that","are","carried","out","on","phospho-bases",",","phosphoethanolamine",",","phospho-N-methylethanolamine",",","and","phospho-N-dimethylethanolamine",";","the","process","ends","with","the","conversion","of","a","phosphatidyl-N-dimethylethanolamine","to","a","phosphatidylcholine","."),4178911). assertion_content_comment('oboGo_PhosphatidylcholineBiosynthesisFromPhosphorylEthanolaminevianDimethylethanolaminephosphateandcdpNDimethylethanolamine',s("The","phosphatidylcholine","biosynthetic","process","that","begins","with","two","N-methylations","with","phospho-base","phosphoethanolamine","and","phospho-N-methylethanolamine",",","followed","by","a","downstream","N-methylation","on","phosphatidyl-base","phosphatidyl-N-dimethylethanolamine",";","the","process","ends","with","the","conversion","of","a","phosphatidyl-N-dimethylethanolamine","to","a","phosphatidylcholine","."),4178836). assertion_content_comment('oboGo_Phosphatidylcholine_CardiolipinOLinoleoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","linoleoyl","(","(","9Z",",","12Z",")","-octadeca-9",",","12-dienoyl",")","group","from","phosphatidylcholine","to","an","oxygen","atom","on","a","cardiolipin","molecule","."),4331781). assertion_content_comment('oboGo_PhosphatidylcholineDolicholoAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","1",",","2-diacyl-sn-glycero-3-phosphocholine","+","dolichol","=","1-acyl-sn-glycero-3-phosphocholine","+","acyldolichol","."),4366133). assertion_content_comment('oboGo_PhosphatidylcholineRetinoloAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","retinol-","[","cellular-retinol-binding-protein","]","+","phosphatidylcholine","=","retinyl-ester-","[","cellular-retinol-binding-protein","]","+","2-acylglycerophosphocholine","."),4366364). assertion_content_comment('oboGo_PhosphatidylcholineSteroloAcyltransferaseactivatoractivity',s("Increases","the","activity","of","phosphatidylcholine-sterol","O-acyltransferase",",","an","enzyme","that","converts","cholesterol","and","phosphatidylcholine","(","lecithins",")","to","cholesteryl","esters","and","lyso-phosphatidylcholines","."),4160047). assertion_content_comment('oboGo_PhosphatidylcholineSteroloAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","phosphatidylcholine","+","a","sterol","=","a","sterol","ester","+","1-acylglycerophosphocholine","."),4203782). assertion_content_comment('oboGo_Phosphatidylethanolamine_Kdo2Lipidaphosphoethanolaminetransferaseactivity',s("Catalysis","of","the","reaction",":","Kdo2-lipid","A","+","phosphatidylethanolamine","=","phosphoethanolamine-Kdo2-lipid","A","+","diacylglycerol","."),4327360). assertion_content_comment('oboGo_PhosphatidylethanolamineNMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","phosphatidylethanolamine","=","S-adenosyl-L-homocysteine","+","H","(","+",")","+","phosphatidyl-N-methylethanolamine","."),4203765). assertion_content_comment('oboGo_PhosphatidylethanolamineSteroloAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","a","phosphatidylethanolamine","+","a","sterol","=","a","sterol","ester","+","a","lysophosphatidylethanolamine","."),4182481). assertion_content_comment('oboGo_PhosphatidylglycerolMembraneOligosaccharideglycerophosphotransferaseactivity',s("Catalysis","of","the","reaction",":","phosphatidylglycerol","+","membrane-derived-oligosaccharide","D-glucose","=","1",",","2-diacyl-sn-glycerol","+","membrane-derived-oligosaccharide","6-","(","glycerophospho",")","-D-glucose","."),4247769). assertion_content_comment('oboGo_PhosphatidylglycerolProlipoproteindiacylglyceryltransferaseactivity',s("Catalysis","of","the","transfer","of","the","diacylglyceryl","group","from","phosphatidylglycerol","to","the","sulfhydryl","group","of","the","prospective","N-terminal","cysteine","residue","in","an","unmodified","prolipoprotein","."),4247759). assertion_content_comment('oboGo_Phosphatidylinositol_345_Trisphosphate3_PhosphataseActivity',s("Catalysis","of","the","reaction",":","phosphatidylinositol-3",",","4",",","5-trisphosphate","+","H2O","=","phosphatidylinositol-4",",","5-bisphosphate","+","phosphate","."),4304265). assertion_content_comment('oboGo_Phosphatidylinositol_345_Trisphosphate5_PhosphataseActivity',s("Catalysis","of","the","reaction",":","phosphatidylinositol-3",",","4",",","5-trisphosphate","+","H2O","=","phosphatidylinositol-3",",","4-bisphosphate","+","phosphate","."),4357524). assertion_content_comment('oboGo_Phosphatidylinositol_345_TrisphosphateBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylinositol-3",",","4",",","5-trisphosphate",",","a","derivative","of","phosphatidylinositol","in","which","the","inositol","ring","is","phosphorylated","at","the","3","'",",","4","'","and","5","'","positions","."),4218898). assertion_content_comment('oboGo_Phosphatidylinositol_34_Bisphosphate3_PhosphataseActivity',s("Catalysis","of","the","reaction",":","phosphatidylinositol-3",",","4-bisphosphate","+","H2O","=","phosphatidylinositol-4-phosphate","+","phosphate","."),4281583). assertion_content_comment('oboGo_Phosphatidylinositol_34_Bisphosphate4_PhosphataseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-myo-inositol","3",",","4-bisphosphate","+","H2O","=","1-phosphatidyl-1D-myo-inositol","3-phosphate","+","phosphate","."),4207090). assertion_content_comment('oboGo_Phosphatidylinositol_34_BisphosphateBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylinositol-3",",","4-bisphosphate",",","a","derivative","of","phosphatidylinositol","in","which","the","inositol","ring","is","phosphorylated","at","the","3","'","and","4","'","positions","."),4318221). assertion_content_comment('oboGo_Phosphatidylinositol_35_Bisphosphate3_PhosphataseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","3",",","5-bisphosphate","+","H2O","=","a","1-phosphatidyl-1D-myo-inositol","5-phosphate","+","phosphate","+","2","H","+"),4191201). assertion_content_comment('oboGo_Phosphatidylinositol_35_Bisphosphate5_PhosphataseActivity',s("Catalysis","of","the","reaction",":","phosphatidylinositol-3",",","5-bisphosphate","+","H2O","=","phosphatidylinositol-3-phosphate","+","orthophosphate","."),4327498). assertion_content_comment('oboGo_Phosphatidylinositol_35_BisphosphateBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylinositol-3",",","5-bisphosphate",",","a","derivative","of","phosphatidylinositol","in","which","the","inositol","ring","is","phosphorylated","at","the","3","'","and","5","'","positions","."),4182288). assertion_content_comment('oboGo_Phosphatidylinositol3Kinaseactivityclassiii',s("OBSOLETE",".","A","phosphoinositide","3-kinase","which","can","only","phosphorylate","phosphatidylinositol","."),4304293). assertion_content_comment('oboGo_Phosphatidylinositol3Kinaseactivityclassii',s("OBSOLETE",".","A","phosphoinositide","3-kinase","which","can","phosphorylate","phosphatidylinositol","and","phosphatidylinositol-4-phosphate",";","the","human","form","can","phosphorylate","phosphatidylinositol-4",",","5-bisphosphate","in","the","presence","of","phosphatidylserine","."),4304281). assertion_content_comment('oboGo_Phosphatidylinositol3Kinaseactivityclassi',s("OBSOLETE",".","A","heterodimeric","phosphoinositide","3-kinase","which","can","phosphorylate","phosphatidylinositol",",","phosphatidylinositol-4-phosphate","or","phosphatidylinositol-4",",","5-bisphosphate",".","Also","possesses","intrinsic","protein","kinase","activity","."),4304306). assertion_content_comment('oboGo_Phosphatidylinositol3Kinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","a","phosphatidylinositol","=","ADP","+","a","phosphatidylinositol","3-phosphate",".","This","reaction","is","the","addition","of","a","phosphate","group","to","an","inositol","lipid","at","the","3","'","position","of","the","inositol","ring","to","generate","the","3-phosphoinositides",":","phosphatidylinositol-3-phosphate","[","PI","(","3",")","P","]",",","phosphatidylinositol-3",",","4-bisphosphate","[","PI","(","3",",","4",")","P2","]","and","phosphatidylinositol-3",",","4",",","5-trisphosphate","[","PI","(","3",",","4",",","5",")","P3","]"),4297614). assertion_content_comment('oboGo_Phosphatidylinositol3Kinasebinding',s("Interacting","selectively","and","non-covalently","with","a","phosphatidylinositol","3-kinase",",","any","enzyme","that","catalyzes","the","addition","of","a","phosphate","group","to","an","inositol","lipid","at","the","3","'","position","of","the","inositol","ring","."),4325528). assertion_content_comment('oboGo_Phosphatidylinositol3Kinasecascadeinvolvedininsulinreceptorsignaling',s("The","process","in","which","a","signal","is","passed","from","the","insulin","receptor","to","components","of","the","phosphatidylinositol","3-kinase","(","PI3K",")","cascade",",","which","become","activated","themselves","to","further","propagate","the","signal","and","finally","trigger","a","change","in","the","function","or","state","of","the","cell","."),4082300). assertion_content_comment('oboGo_Phosphatidylinositol3Kinasecascade',s("A","series","of","reactions",",","mediated","by","the","intracellular","phosphatidylinositol","3-kinase","(","PI3K",")","PI3K","cascades","lie","downstream","of","many","cell","surface","receptor","linked","signaling","pathways","and","regulate","numerous","cellular","functions","."),4039913). assertion_content_comment('oboGo_Phosphatidylinositol3Kinaseclassicatalystactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","1-phosphatidyl-1D-myo-inositol","=","ADP","+","1-phosphatidyl-1D-myo-inositol","3-phosphate","."),4297664). assertion_content_comment('oboGo_Phosphatidylinositol3Kinaseclassiregulatoractivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","1-phosphatidyl-1D-myo-inositol","=","ADP","+","1-phosphatidyl-1D-myo-inositol","3-phosphate","."),4297587). assertion_content_comment('oboGo_Phosphatidylinositol3Kinasecomplexclassiii',s("A","complex","containing","a","heterodimer","of","a","catalytic","Class","III","phosphoinositide","3-kinase","(","PI3K",")","subunit","bound","to","a","regulatory","(","adaptor",")","subunit",".","Class","III","PI3Ks","have","a","substrate","specificity","restricted","to","phosphatidylinositol","(","PI",")"),4381754). assertion_content_comment('oboGo_Phosphatidylinositol3Kinasecomplexii',s("A","protein","complex","that","posseses","phosphatidylinositol","3-kinase","activity","and","is","involved","in","vacuolar","protein","sorting","(","VPS",")","via","endosomes",".","In","budding","yeast",",","this","complex","consists","of","Vps30p",",","Vps34p",",","VPS38","and","Vps15p","."),4360349). assertion_content_comment('oboGo_Phosphatidylinositol3Kinasecomplexi',s("A","protein","complex","that","posseses","phosphatidylinositol","3-kinase","activity","and","is","involved","in","autophagy",".","In","budding","yeast",",","this","complex","consists","of","Vps30p",",","Vps34p",",","Atg14p","and","Vps15p","."),4360338). assertion_content_comment('oboGo_Phosphatidylinositol3Kinasecomplex',s("A","complex","containing","a","heterodimer","of","a","catalytic","subunit","and","a","regulatory","(","adaptor",")","subunit","of","any","phosphatidylinositol","3-kinase","(","PI3K",")"),4220707). assertion_content_comment('oboGo_Phosphatidylinositol3Kinaseregulatoractivity',s("Modulates","the","activity","of","any","of","the","phosphatidylinositol","3-kinases","(","PI3Ks",")","Regulatory","subunits","can","link","a","PI3K","catalytic","subunit","to","upstream","signaling","events","and","help","position","the","catalytic","subunits","close","to","their","lipid","substrates","."),4297578). assertion_content_comment('oboGo_Phosphatidylinositol_3_PhosphataseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","3-phosphate","+","H2O","=","1-phosphatidyl-1D-myo-inositol","+","phosphate","."),4206568). assertion_content_comment('oboGo_Phosphatidylinositol_3_PhosphateBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylinositol-3-phosphate",",","a","derivative","of","phosphatidylinositol","in","which","the","inositol","ring","is","phosphorylated","at","the","3","'","position","."),4329820). assertion_content_comment('oboGo_Phosphatidylinositol_45_Bisphosphate3_KinaseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","4",",","5-bisphosphate","+","ATP","=","a","1-phosphatidyl-1D-myo-inositol","3",",","4",",","5-trisphosphate","+","ADP","+","2","H","(","+",")"),4297656). assertion_content_comment('oboGo_Phosphatidylinositol_45_Bisphosphate4_PhosphataseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-myo-inositol","4",",","5-bisphosphate","+","H2O","=","1-phosphatidyl-1D-myo-inositol","3-phosphate","+","phosphate","."),4352462). assertion_content_comment('oboGo_Phosphatidylinositol_45_Bisphosphate5_PhosphataseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","4",",","5-bisphosphate","+","H","(","2",")","O","=","1-phosphatidyl-1D-myo-inositol","4-phosphate","+","phosphate","."),4206598). assertion_content_comment('oboGo_Phosphatidylinositol_45_BisphosphateBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylinositol-4",",","5-bisphosphate",",","a","derivative","of","phosphatidylinositol","in","which","the","inositol","ring","is","phosphorylated","at","the","4","'","and","5","'","positions","."),4218917). assertion_content_comment('oboGo_Phosphatidylinositol_45_BisphosphateHydrolysis',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236241). assertion_content_comment('oboGo_Phosphatidylinositol_4_Phosphate3_KinaseActivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","4-phosphate","+","ATP","=","1-phosphatidyl-1D-myo-inositol","3",",","4-bisphosphate","+","ADP","+","2","H","(","+",")"),4297640). assertion_content_comment('oboGo_Phosphatidylinositol_4_PhosphateBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylinositol-4-phosphate",",","a","derivative","of","phosphatidylinositol","in","which","the","inositol","ring","is","phosphorylated","at","the","4","'","position","."),4174341). assertion_content_comment('oboGo_Phosphatidylinositol_4_PhosphatePhosphataseActivity',s("Catalysis","of","the","reaction",":","phosphatidylinositol-4-phosphate","+","H2O","=","phosphatidylinositol","+","orthophosphate","."),4327568). assertion_content_comment('oboGo_Phosphatidylinositol_5_PhosphateBinding',s("Interacting","selectively","and","non-covalently","with","phosphatidylinositol-5-phosphate",",","a","derivative","of","phosphatidylinositol","in","which","the","inositol","ring","is","phosphorylated","at","the","5","'","position","."),4332573). assertion_content_comment('oboGo_PhosphatidylinositolAlphaMannosyltransferaseactivity',s("Catalysis","of","the","transfer","of","one","or","more","alpha-D-mannose","residues","from","GDP-mannose","to","positions","2",",","6","and","others","in","1-phosphatidyl-myo-inositol","."),4325966). assertion_content_comment('oboGo_PhosphatidylinositolDiacylglycerolLyaseactivity',s("Catalysis","of","the","reaction",":","1-phosphatidyl-1D-myo-inositol","=","D-myo-inositol","1",",","2-cyclic","phosphate","+","diacylglycerol","."),4206627). assertion_content_comment('oboGo_PhosphatidylinositolMediatedsignaling',s("A","series","of","molecular","signals","in","which","a","cell","uses","a","phosphatidylinositol-mediated","signaling","to","convert","a","signal","into","a","response",".","Phosphatidylinositols","include","phosphatidylinositol","(","PtdIns",")","and","its","phosphorylated","derivatives","."),4233036). assertion_content_comment('oboGo_PhosphatidylinositolNAcetylglucosaminyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-D-glucosamine","+","phosphatidylinositol","=","UDP","+","N-acetyl-D-glucosaminylphosphatidylinositol","."),4258256). assertion_content_comment('oboGo_PhosphatidylinositolPhosphate4Phosphataseactivity',s("Catalysis","of","the","removal","the","of","the","4-phosphate","group","of","a","phosphatidylinositol","phosphate","."),4207086). assertion_content_comment('oboGo_PhosphatidylinositolPhosphate5Phosphataseactivity',s("Catalysis","of","the","removal","the","of","the","5-phosphate","group","of","a","phosphatidylinositol","phosphate","."),4206594). assertion_content_comment('oboGo_PhosphatidylNDimethylethanolaminenMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","phosphatidyl-N-dimethylethanolamine","=","S-adenosyl-L-homocysteine","+","phosphatidylcholine","."),4181524). assertion_content_comment('oboGo_PhosphatidylNMethylethanolaminenMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","phosphatidyl-N-methylethanolamine","=","S-adenosyl-L-homocysteine","+","phosphatidyl-N-dimethylethanolamine","."),4363693). assertion_content_comment('oboGo_PhosphatidylNMonomethylethanolaminebiosyntheticprocess',s("The","chemical","reactions","and","pathways","involving","phosphatidyl-N-monomethylethanolamine","(","PMME",")",",","a","derivative","of","phosphatidylethanolamine","with","a","methylated","amine","group","."),4230445). assertion_content_comment('oboGo_PhosphatidylNMonomethylethanolaminemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","phosphatidyl-N-monomethylethanolamine","(","PMME",")",",","a","derivative","of","phosphatidylethanolamine","with","a","methylated","amine","group",".","Present","in","trace","levels","in","plants","and","slightly","higher","in","bacteria","."),4230440). assertion_content_comment('oboGo_PhosphatidylserineSpecificphospholipasea1activity',s("Catalysis","of","the","reaction",":","phosphatidylcholine","+","H2O","=","2-acylglycerophosphocholine","+","a","fatty","acid","anion","."),4269572). assertion_content_comment('oboGo_PhosphoadenylylSulfatereductasethioredoxinactivity',s("Catalysis","of","the","reaction",":","adenosine","3","'",",","5","'","-diphosphate","+","H","(","+",")","+","sulfite","+","thioredoxin","disulfide","=","3","'","-phospho-5","'","-adenylyl","sulfate","+","thioredoxin",".","Thioredoxin","disulfide","is","the","oxidized","form","of","thioredoxin",";","3","'","-phosphoadenosine","5","'","-phosphosulfate","is","also","known","as","PAPS","."),4203658). assertion_content_comment('oboGo_PhosphoenolpyruvateDependentsugarphosphotransferasecomplex',s("Includes","phosphoenolpyruvate-protein","phosphatase","(","enzyme","I","of","the","phosphotransferase","system",")","and","protein-N","(","PI",")","-phosphohistidine-sugar","phosphotransferase","(","enzyme","II","of","the","phosphotransferase","system",")"),4237918). assertion_content_comment('oboGo_PhosphoenolpyruvateDependentsugarphosphotransferasesystem',s("The","uptake","and","phosphorylation","of","specific","carbohydrates","from","the","extracellular","environment",";","uptake","and","phosphorylation","are","coupled",",","making","the","PTS","a","link","between","the","uptake","and","metabolism","of","sugars",";","phosphoenolpyruvate","is","the","original","phosphate","donor",";","phosphoenolpyruvate","passes","the","phosphate","via","a","signal","transduction","pathway",",","to","enzyme","1","(","E1",")",",","which","in","turn","passes","it","on","to","the","histidine","protein",",","HPr",";","the","next","step","in","the","system","involves","sugar-specific","membrane-bound","complex",",","enzyme","2","(","EII",")",",","which","transports","the","sugar","into","the","cell",";","it","includes","the","sugar","permease",",","which","catalyzes","the","transport","reactions",";","EII","is","usually","divided","into","three","different","domains",",","EIIA",",","EIIB",",","and","EIIC","."),4258527). assertion_content_comment('oboGo_PhosphoenolpyruvateGlyceronephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","glycerone","+","phosphoenolpyruvate","=","glycerone","phosphate","+","pyruvate","."),4368986). assertion_content_comment('oboGo_PhosphoenolpyruvateProteinphosphotransferaseactivity',s("Catalysis","of","the","reaction",":","phosphoenolpyruvate","+","protein","L-histidine","=","pyruvate","+","protein","N","(","pi",")","-phospho-L-histidine","."),4247810). assertion_content_comment('oboGo_PhosphoethanolamineNMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","ethanolamine","phosphate","=","S-adenosyl-L-homocysteine","+","N-methylethanolamine","phosphate","."),4346238). assertion_content_comment('oboGo_PhosphoglucomutaseGlucoseCofactoractivity',s("Catalysis","of","the","reaction",":","glucose-1-phosphate","=","glucose-6-phosphate",";","using","D-glucose","as","a","cofactor","."),4369531). assertion_content_comment('oboGo_Phosphogluconate2Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","6-phospho-D-gluconate","+","NADP","+","=","6-phospho-2-dehydro-D-gluconate","+","NADPH","."),4246285). assertion_content_comment('oboGo_PhospholipaseCMediatedactivationofappressoriumformation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","symbiont","phospholipase","C-mediated","signal","transduction","during","appressorium","formation","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153852). assertion_content_comment('oboGo_PhospholipidHydroperoxideglutathioneperoxidaseactivity',s("Catalysis","of","the","reaction",":","a","lipid","hydroperoxide","+","2","reduced","glutathione","=","2","H2O","+","lipid","+","2","oxidized","glutathione","."),4364774). assertion_content_comment('oboGo_PhospholipidScrambling_8',s("OBSOLETE",".","The","trans-bilayer","migration","of","phospholipids","accelerated","by","a","phospholipid","scramblase","upon","binding","calcium","ions","."),4254434). assertion_content_comment('oboGo_PhospholipidTranslocatingatpaseactivity',s("Catalysis","of","the","movement","of","phospholipids","from","one","membrane","bilayer","leaflet","to","the","other","(","phospolipid","'","flippase","'","activity",")",",","driven","by","the","hydrolysis","of","ATP","."),4213138). assertion_content_comment('oboGo_PhosphomethylethanolamineNMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","N-methylethanolamine","phosphate","+","S-adenosyl-L-methionine","=","N",",","N-dimethylethanolamine","phosphate","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4192096). assertion_content_comment('oboGo_PhosphoNAcetylmuramoylPentapeptideTransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine","+","undecaprenyl","phosphate","=","UMP","+","N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol","."),4247723). assertion_content_comment('oboGo_PhosphonateTransmembraneTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","phosphonate","(","out",")","=","ADP","+","phosphate","+","phosphonate","(","in",")","A","phosphonate","is","any","salt",",","anion",",","or","ester","of","phosphonic","acid","(","HPO","(","OH",")","2",")"),4291417). assertion_content_comment('oboGo_PhosphopantothenateCysteineligaseactivity',s("Catalysis","of","the","reaction",":","CTP","+","(","R",")","-4","'","-phosphopantothenate","+","L-cysteine","=","CMP","+","diphosphate","+","(","R",")","-4","'","-phosphopantothenoyl-L-cysteine",".","Cysteine","can","be","replaced","by","some","of","its","derivatives","."),4202840). assertion_content_comment('oboGo_PhosphoramidateHexosephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","hexose","+","phosphoramidate","=","hexose","1-phosphate","+","NH3","."),4368249). assertion_content_comment('oboGo_PhosphoribosylamineGlycineligaseactivity',s("Catalysis","of","the","reaction",":","5-phospho-D-ribosylamine","+","ATP","+","glycine","=","N","(","1",")","-","(","5-phospho-D-ribosyl",")","glycinamide","+","ADP","+","2","H","(","+",")","+","phosphate","."),4202885). assertion_content_comment('oboGo_PhosphoribosylAmpcyclohydrolaseactivity',s("Catalysis","of","the","reaction",":","1-","(","5-phosphonatoribosyl",")","-5","'","-AMP","+","H","(","2",")","O","=","1-","(","5-phosphoribosyl",")","-5-","[","(","5-phosphoribosylamino",")","methylideneamino","]","imidazole-4-carboxamide","."),4202918). assertion_content_comment('oboGo_PhosphoribosylAtpdiphosphataseactivity',s("Catalysis","of","the","reaction",":","1-","(","5-phospho-D-ribosyl",")","-ATP","+","H","(","2",")","O","=","1-","(","5-phosphonatoribosyl",")","-5","'","-AMP","+","diphosphate","+","H","(","+",")"),4202905). assertion_content_comment('oboGo_PhosphoribosylformylglycinamidineCycloLigaseactivity',s("Catalysis","of","the","reaction",":","2-","(","formamido",")","-N","(","1",")","-","(","5-phospho-D-ribosyl",")","acetamidine","+","ATP","=","5-amino-1-","(","5-phospho-D-ribosyl",")","imidazole","+","ADP","+","2","H","(","+",")","+","phosphate","."),4203495). assertion_content_comment('oboGo_PhosphorusOxygenlyaseactivity',s("Catalysis","of","the","cleavage","of","a","phosphorus-oxygen","bond","by","other","means","than","by","hydrolysis","or","oxidation",",","or","conversely","adding","a","group","to","a","double","bond","."),4206625). assertion_content_comment('oboGo_PhosphorylationGatedchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","solute","by","a","channel","that","opens","in","response","to","phosphorylation","of","one","of","its","constituent","parts","."),4331028). assertion_content_comment('oboGo_PhosphorylationOfRNAPolymeraseIICTerminaldomainserine2residues',s("The","process","of","introducing","a","phosphate","group","onto","a","serine","residue","at","position","2","within","the","heptapeptide","repeat","(","YSPTSPS",")","of","the","C-terminal","domain","of","RNA","polymerase","II",".","Typically",",","phosphorylation","of","serine","2","(","Ser2",")","occurs","subsequent","to","phosphorylation","of","serine","5","and","is","thus","seen","in","the","middle","and","3","'","ends","of","genes",".","In","vivo",",","Ser5","phosphorylation","is","primarily","performed","by","CTDK-I","in","S",".","cerevisiae","or","CDK9","in","metazoans","."),4172618). assertion_content_comment('oboGo_PhosphorylationOfRNAPolymeraseIICTerminaldomainserine5residues',s("The","process","of","introducing","a","phosphate","group","onto","a","serine","residue","at","position","5","within","the","heptapeptide","repeat","(","YSPTSPS",")","of","the","C-terminal","domain","of","RNA","polymerase","II",".","Typically",",","phosphorylation","of","serine","5","(","Ser5",")","occurs","near","the","5","'","ends","of","genes",".","It","is","generally","still","observed","in","the","middle","of","genes",",","overlapping","with","phosphorylation","of","serine","2",",","but","is","generally","not","present","at","the","3","'","ends","of","genes",".","In","vivo",",","Ser5","phosphorylation","occurs","primarily","through","the","action","of","TFIIH","(","KIN28","in","S",".","cerevisiae",",","CKD7","in","metazoans",")"),4172879). assertion_content_comment('oboGo_PhosphorylationOfRNAPolymeraseIICTerminaldomain',s("The","process","of","introducing","a","phosphate","group","on","to","an","amino","acid","residue","in","the","C-terminal","domain","of","RNA","polymerase","II",".","Typically",",","this","occurs","during","the","transcription","cycle","and","results","in","production","of","an","RNA","polymerase","II","enzyme","where","the","carboxy-terminal","domain","(","CTD",")","of","the","largest","subunit","is","extensively","phosphorylated",",","often","referred","to","as","hyperphosphorylated","or","the","II","(","0",")","form",".","Specific","types","of","phosphorylation","within","the","CTD","are","usually","associated","with","specific","regions","of","genes",",","though","there","are","exceptions",".","The","phosphorylation","state","regulates","the","association","of","specific","complexes","such","as","the","capping","enzyme","or","3","'","-RNA","processing","machinery","to","the","elongating","RNA","polymerase","complex","."),4172612). assertion_content_comment('oboGo_PhosphoserineTrnacysligaseactivity',s("Catalysis","of","the","reaction",":","tRNA","(","Cys",")","+","O-phospho-L-serine","+","ATP","=","AMP","+","diphosphate","+","phosphoseryl-tRNA","(","Cys",")"),4327533). assertion_content_comment('oboGo_PhotinusLuciferin4MonooxygenaseatpHydrolyzingactivity',s("Catalysis","of","the","reaction",":","O2","+","ATP","+","Photinus","luciferin","=","light","+","diphosphate","+","AMP","+","CO2","+","oxidized","Photinus","luciferin","."),4365110). assertion_content_comment('oboGo_PhotoreceptorCyclicNucleotidephosphodiesteraseactivity',s("Catalysis","of","the","reaction",":","nucleoside","cyclic","phosphate","+","H2O","=","nucleoside","phosphate",".","This","reaction","is","the","hydrolysis","of","bonds","in","a","cyclic","nucleotide","."),4211507). assertion_content_comment('oboGo_PhotosyntheticElectronTransportChain_6',s("OBSOLETE",".","A","series","of","membrane-linked","oxidation-reduction","reactions","in","which","electrons","are","transferred","from","an","initial","electron","donor","through","a","series","of","intermediates","to","a","final","electron","acceptor","(","usually","oxygen",")"),4259516). assertion_content_comment('oboGo_Phthalate34CisDihydrodioldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","phthalate","3",",","4-cis-dihydrodiol","+","NAD","+","=","3",",","4-dihydroxyphthalate","+","NADH","+","H","+"),4350403). assertion_content_comment('oboGo_Phthalate34Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","phthalate","+","O2","+","NADH","+","H","+","=","phthalate","3",",","4-cis-dihydrodiol","+","NAD","+"),4350385). assertion_content_comment('oboGo_Phthalate45CisDihydrodioldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","cis-4",",","5-dihydroxycyclohexa-2",",","6-diene-1",",","2-dicarboxylate","+","NAD","(","+",")","=","4",",","5-dihydroxyphthalate","+","H","(","+",")","+","NADH","."),4278478). assertion_content_comment('oboGo_Phthalate45Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADH","+","O","(","2",")","+","phthalate","=","cis-4",",","5-dihydroxycyclohexa-2",",","6-diene-1",",","2-dicarboxylate","+","NAD","(","+",")"),4276127). assertion_content_comment('oboGo_PhylloquinoneMonooxygenase23Epoxidizingactivity',s("Catalysis","of","the","reaction",":","AH","(","2",")","+","O","(","2",")","+","phylloquinone","=","2",",","3-epoxyphylloquinone","+","A","+","H","(","2",")","O","."),4364637). assertion_content_comment('oboGo_PhytanateCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","CoA","+","phytanate","=","AMP","+","diphosphate","+","H","(","+",")","+","phytanoyl-CoA","."),4263005). assertion_content_comment('oboGo_PhytanoylCoadioxygenaseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","O","(","2",")","+","phytanoyl-CoA","=","2-hydroxyphytanoyl-CoA","+","CO","(","2",")","+","succinate","."),4384897). assertion_content_comment('oboGo_PiBody',s("A","P","granule","that","contains","the","PIWIL2-TDRD1","module",",","a","set","of","proteins","that","act","in","the","primary","piRNA","pathway",".","The","pi-body","corresponds","to","the","cementing","material","between","mitochondria","found","in","gonocytes","."),4171385). assertion_content_comment('oboGo_PIClnSmproteincomplex',s("A","protein","complex","that","contains","pICln","(","CLNS1A",")","and","several","Sm","proteins",",","including","SmD1",",","SmD2",",","SmE",",","SmF",",","and","SmG","."),4349091). assertion_content_comment('oboGo_PimeloylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NAD","(","+",")","+","pimelyl-CoA","=","2",",","3-didehydropimeloyl-CoA","+","H","(","+",")","+","NADH","."),4278543). assertion_content_comment('oboGo_Pinacolone5Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","2",",","2-dimethyl-3-pentanone","+","1/2","O2","=","1-hydroxy-4",",","4-dimethylpentan-3-one","."),4351001). assertion_content_comment('oboGo_PiPBody',s("A","P","granule","that","contains","the","PIWIL4-TDRD9","module",",","a","set","of","proteins","that","act","in","the","secondary","piRNA","pathway","."),4171376). assertion_content_comment('oboGo_PiperidineNPiperoyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","E",",","E",")","-piperoyl-CoA","+","piperidine","=","N-","[","(","E",",","E",")","-piperoyl","]","piperidine","+","CoA","+","H","(","+",")"),4263028). assertion_content_comment('oboGo_PituitaryAdenylateCyclaseActivatingpolypeptidereceptoractivity',s("A","G-protein","coupled","receptor","that","interacts","with","pituitary","adenylate","cyclase-activating","polypeptide","."),4383918). assertion_content_comment('oboGo_PituitaryAdenylateCyclaseActivatingpolypeptidereceptorbinding',s("Interacting","selectively","and","non-covalently","with","a","pituitary","adenylate","cyclase-activating","polypeptide","receptor","."),4324133). assertion_content_comment('oboGo_PivalateCoaligaseactivity',s("Catalysis","of","the","reaction",":","pivalate","+","H","+","+","HSCoA","+","ATP","=","pivalyl-CoA","+","PPi","+","AMP","."),4349692). assertion_content_comment('oboGo_PivalylCoamutaseactivity',s("Catalysis","of","the","reaction",":","pivalyl-CoA","=","3-methylbutyryl-CoA","."),4349668). assertion_content_comment('oboGo_PlantTypecellwallassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","cellulose-","and","pectin-containing","cell","wall","."),4031914). assertion_content_comment('oboGo_PlantTypecellwallbiogenesis',s("A","cellular","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","and","arrangement","of","constituent","parts","of","a","cellulose","and","pectin-containing","cell","wall",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),4021475). assertion_content_comment('oboGo_PlantTypecellwallcellulosemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","cellulose",",","a","linear","beta1-4","glucan","of","molecular","mass","50-400","kDa","with","the","pyranose","units","in","the","-4C1","conformation",",","as","part","of","the","organization","and","biogenesis","of","the","cell","wall","."),4109998). assertion_content_comment('oboGo_PlantTypecellwallloosening',s("The","series","of","events","causing","chemical","and","structural","alterations","of","an","existing","cellulose","and","pectin-containing","cell","wall","that","results","in","greater","extensibility","of","the","wall",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),4262358). assertion_content_comment('oboGo_PlantTypecellwallmodificationinvolvedinmultidimensionalcellgrowth',s("The","series","of","events","that","occur","during","cell","growth","that","result","in","chemical","or","structural","changes","to","existing","cell","walls","of","the","type","composed","chiefly","of","cellulose","and","pectin",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),4262563). assertion_content_comment('oboGo_PlantTypecellwallmodification',s("The","series","of","events","leading","to","chemical","and","structural","alterations","of","an","existing","cellulose","and","pectin-containing","cell","wall","that","can","result","in","loosening",",","increased","extensibility","or","disassembly",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),4021726). assertion_content_comment('oboGo_PlantTypecellwallorganizationorbiogenesis',s("A","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","cellulose-","and","pectin-containing","cell","wall","."),4021472). assertion_content_comment('oboGo_PlantTypecellwallorganization',s("A","process","that","results","in","the","assembly","and","arrangement","of","constituent","parts","of","the","cellulose","and","pectin-containing","cell","wall",",","or","in","the","disassembly","of","the","cellulose","and","pectin-containing","cell","wall",".","This","process","is","carried","out","at","the","cellular","level",".","An","example","of","this","process","is","found","in","Arabidopsis","thaliana","."),4021709). assertion_content_comment('oboGo_PlantTypecellwall',s("A","more","or","less","rigid","stucture","lying","outside","the","cell","membrane","of","a","cell","and","composed","of","cellulose","and","pectin","and","other","organic","and","inorganic","substances","."),4023031). assertion_content_comment('oboGo_PlantTypehypersensitiveresponse',s("The","rapid",",","localized","death","of","plant","cells","in","response","to","invasion","by","a","pathogen","."),4031159). assertion_content_comment('oboGo_PlantTypesporedevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","spore","over","time",",","from","its","formation","to","the","mature","structure",".","The","spore","gives","rise","to","gametophytes","."),4023123). assertion_content_comment('oboGo_PlantTypevacuolelumen',s("The","volume","enclosed","within","the","vacuolar","membrane","of","a","vacuole","that","retains","the","same","shape","regardless","of","cell","cycle","phase",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),3975085). assertion_content_comment('oboGo_PlantTypevacuolemembrane',s("The","lipid","bilayer","surrounding","a","vacuole","that","retains","the","same","shape","regardless","of","cell","cycle","phase",".","The","membrane","separates","its","contents","from","the","cytoplasm","of","the","cell",".","An","example","of","this","component","is","found","in","Arabidopsis","thaliana","."),4022647). assertion_content_comment('oboGo_PlantTypevacuole',s("A","closed","structure","that","is","completely","surrounded","by","a","unit","membrane",",","contains","liquid",",","and","retains","the","same","shape","regardless","of","cell","cycle","phase",".","An","example","of","this","structure","is","found","in","Arabidopsis","thaliana","."),3974379). assertion_content_comment('oboGo_PlasmaKallikreinKinincascade',s("A","series","of","reactions","that","takes","place","outside","the","cell","occurring","in","response","to","tissue","damage","and","initiated","within","blood","plasma","by","the","action","of","activated","Factor","XII","(","Hageman","Factor",")","on","prekallikrein","to","convert","it","to","plasma","kallikrein",",","and","the","subsequent","reaction","of","plasma","kallikrein","with","high","molecular","weight","kininogen",".","The","ultimate","product","of","the","plasma","kallikrein-kinin","cascade","is","bradykinin",",","an","agent","known","to","induce","smooth","muscle","contraction",",","vasoconstriction",",","and","increased","vascular","permeability","."),3996009). assertion_content_comment('oboGo_PlasmaMembraneCationTransportingatpase',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4212962). assertion_content_comment('oboGo_PlasmaMembraneDerivedchromatophoremembrane',s("The","lipid","bilayer","associated","with","a","plasma","membrane-derived","chromatophore",";","surrounds","chromatophores","that","form","complete","vesicles","."),4056848). assertion_content_comment('oboGo_PlasmaMembraneDerivedchromatophore',s("A","pigment-bearing","structure","that","is","derived","from","the","cytoplasmic","membrane",",","sometimes","consisting","of","simple","invaginations","and","sometimes","a","complete","vesicle",".","This","component","is","found","in","certain","photosynthetic","bacteria","and","cyanobacteria","."),4052841). assertion_content_comment('oboGo_PlasmaMembraneDerivedphotosystemi',s("A","protein","complex","located","in","the","plasma","membrane-derived","thylakoid",".","The","photosystem","functions","as","a","light-dependent","plastocyanin-ferredoxin","oxidoreductase",",","transferring","electrons","from","plastocyanin","to","ferredoxin",".","Examples","of","this","complex","are","found","in","bacterial","species","."),4052986). assertion_content_comment('oboGo_PlasmaMembraneDerivedthylakoidlumen',s("The","volume","enclosed","by","a","plasma","membrane-derived","thylakoid","."),4057742). assertion_content_comment('oboGo_PlasmaMembraneDerivedthylakoidmembrane',s("The","pigmented","membrane","of","a","plasma","membrane-derived","thylakoid","."),4056853). assertion_content_comment('oboGo_PlasmaMembraneDerivedthylakoidphotosystemii',s("A","protein","complex",",","located","in","the","membrane-derived","thylakoid",",","containing","the","P680","reaction","center",".","In","the","light",",","PSII","functions","as","a","water-plastoquinone","oxidoreductase",",","transferring","electrons","from","water","to","plastoquinone","."),4052960). assertion_content_comment('oboGo_PlasmaMembraneDerivedthylakoidribulosebisphosphatecarboxylasecomplex',s("A","complex",",","located","in","the","plasma","membrane-derived","thylakoid",",","containing","either","both","large","and","small","subunits","or","just","small","subunits",".","It","carries","out","the","activity","of","producing","3-phosphoglycerate","from","carbon","dioxide","and","ribulose-1",",","5-bisphosphate","."),4103105). assertion_content_comment('oboGo_PlasmaMembraneDerivedthylakoid',s("A","thylakoid","that","is","derived","from","and","attached","to",",","but","not","necessarily","continuous","with",",","the","plasma","membrane",",","and","is","not","enclosed","in","a","plastid",".","It","bears","the","photosynthetic","pigments","in","photosynthetic","cyanobacteria","."),4052946). assertion_content_comment('oboGo_PlasmaMembraneLightHarvestingcomplex',s("A","plasma","membrane","protein-pigment","complex","that","may","be","closely","or","peripherally","associated","to","photosynthetic","reaction","centers","that","participate","in","harvesting","and","transferring","radiant","energy","to","the","reaction","center",".","Examples","of","this","complex","are","found","in","bacterial","species","."),4052844). assertion_content_comment('oboGo_PlasmaMembraneLongChainfattyacidtransporter',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4345503). assertion_content_comment('oboGo_PlasmaMembraneLongChainfattyacidtransport',s("The","directed","movement","of","long-chain","fatty","acids","across","the","plasma","membrane","."),4024595). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingatpsynthasecatalyticcore',s("The","hexamer","that","possesses","the","catalytic","activity","of","the","plasma","membrane","hydrogen-transporting","ATP","synthase",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4086287). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingatpsynthasecentralstalk',s("One","of","two","stalks","that","connect","the","catalytic","core","of","the","hydrogen-transporting","ATP","synthase","to","the","plasma","membrane-associated","Fo","proteins",";","rotates","within","the","catalytic","core","during","catalysis",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4085646). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingatpsynthasecomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","proton-transporting","ATP","synthase","in","the","plasma","membrane","."),4063555). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingatpsynthasecomplexcatalyticcoref1',s("The","catalytic","sector","of","the","plasma","membrane","hydrogen-transporting","ATP","synthase",";","it","comprises","the","catalytic","core","and","central","stalk",",","and","is","peripherally","associated","with","the","plasma","membrane","when","the","entire","ATP","synthase","is","assembled",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4085632). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingatpsynthasecomplexcouplingfactorfo',s("All","non-F1","subunits","of","the","plasma","membrane","hydrogen-transporting","ATP","synthase",",","including","integral","and","peripheral","plasma","membrane","proteins","."),4086301). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingatpsynthasecomplex',s("A","proton-transporting","ATP","synthase","complex","found","in","the","plasma","membrane",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4085626). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingatpsynthasestatorstalk',s("One","of","two","stalks","that","connect","the","catalytic","core","of","the","hydrogen-transporting","ATP","synthase","to","the","plasma","membrane-associated","F0","proteins",";","is","thought","to","prevent","futile","rotation","of","the","catalytic","core",".","Examples","of","this","component","are","found","in","Bacterial","species","."),4086316). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingvTypeatpasecomplex',s("A","proton-transporting","two-sector","ATPase","complex","found","in","the","plasma","membrane","."),3973273). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingvTypeatpasev0domain',s("The","V0","domain","of","a","proton-transporting","V-type","ATPase","found","in","the","plasma","membrane","."),3973378). assertion_content_comment('oboGo_PlasmaMembraneProtonTransportingvTypeatpasev1domain',s("The","V1","domain","of","a","proton-transporting","V-type","ATPase","found","in","the","plasma","membrane","."),3973276). assertion_content_comment('oboGo_PlasmodesmataMediatedintercellulartransport',s("The","movement","of","substances","between","cells","via","plasmodesmata",".","Plasmodesmata","is","a","fine","cytoplasmic","channel",",","found","in","all","higher","plants",",","that","connects","the","cytoplasm","of","one","cell","to","that","of","an","adjacent","cell","."),4332762). assertion_content_comment('oboGo_PlastidAcetateCoATransferasecomplex',s("An","acetate","CoA-transferase","complex","located","in","the","stroma","of","a","plastid","."),4054555). assertion_content_comment('oboGo_PlastidAcetylCoacarboxylasecomplex',s("An","acetyl-CoA","carboxylase","complex","located","in","the","stroma","of","a","plastid","."),4054532). assertion_content_comment('oboGo_PlastidEncodedplastidrnapolymerasecomplexa',s("A","plastid-encoded","DNA-directed","RNA","polymerase","complex","that","resembles","eubacterial","multisubunit","RNA","polymerases",",","with","a","core","composed","of","alpha",",","beta",",","and","beta-prime","subunits",".","An","additional","subunit",",","a","sigma","factor",",","is","required","for","promoter","recognition",".","PEP-A","is","generated","from","the","PEP-B","form","during","chloroplast","maturation","to","generate","a","complex","composed","of","at","least","thirteen","polypeptides","that","is","not","sensitive","to","the","antibiotic","rifampicin",",","like","its","precursor","form","the","PEP-B","complex","."),4362901). assertion_content_comment('oboGo_PlastidEncodedplastidrnapolymerasecomplexb',s("A","plastid-encoded","DNA-directed","RNA","polymerase","complex","that","resembles","eubacterial","multisubunit","RNA","polymerases","with","a","core","composed","of","alpha",",","beta",",","and","beta-prime","subunits",".","An","additional","subunit",",","a","sigma","factor",",","is","required","for","promoter","recognition",".","PEP-B","is","distinguished","from","PEP-A","by","its","sensitivity","to","the","antibiotic","rifampicin",".","PEP-B","is","found","in","both","etioplasts","and","chloroplasts",",","but","is","the","predominate","form","in","etioplasts",".","It","forms","the","core","of","the","PEP-A","form",";","the","conversion","from","PEP-B","to","PEP-A","occurs","during","chloroplast","maturation","."),4362851). assertion_content_comment('oboGo_PlastidEncodedplastidrnapolymerasecomplex',s("An","RNA","polymerase","complex","containing","polypeptides","encoded","by","the","plastid","genome",".","Plastid-encoded","DNA-directed","RNA","polymerases","resemble","eubacterial","multisubunit","RNA","polymerases",",","with","a","core","composed","of","alpha",",","beta",",","and","beta-prime","subunits",".","Some","forms","contain","multiple","additional","subunits",".","An","additional","sigma","factor","subunit","is","required","for","promoter","recognition","."),4362597). assertion_content_comment('oboGo_PlastidPEPArnapolymeraseactivity',s("Catalysis","of","the","reaction",":","nucleoside","triphosphate","+","RNA","(","n",")","=","diphosphate","+","RNA","(","n","+","1",")","Utilizes","a","DNA","template","that","contains","a","plastid","PEP-A","RNA","polymerase","II","specific","promoter","to","direct","initiation","and","catalyses","DNA-template-directed","extension","of","the","3","'","-end","of","an","RNA","strand","by","one","nucleotide","at","a","time",".","Can","initiate","a","chain","'","de","novo","'"),4355961). assertion_content_comment('oboGo_PlastidPEPBrnapolymeraseactivity',s("Catalysis","of","the","reaction",":","nucleoside","triphosphate","+","RNA","(","n",")","=","diphosphate","+","RNA","(","n","+","1",")","Utilizes","a","DNA","template","that","contains","a","plastid","PEP-B","RNA","polymerase","II","specific","promoter","to","direct","initiation","and","catalyses","DNA-template-directed","extension","of","the","3","'","-end","of","an","RNA","strand","by","one","nucleotide","at","a","time",".","Can","initiate","a","chain","'","de","novo","'"),4355970). assertion_content_comment('oboGo_PlastidSingleSubunittypernapolymerasebinding',s("Interacting","selectively","and","non-covalently","with","a","single","subunit","plastid","RNA","polymerase","enzyme",",","which","is","composed","of","a","single","catalytic","subunit","similar","to","the","RNA","polymerase","enzymes","from","phages","T3",",","T7",",","and","SP6","."),4356110). assertion_content_comment('oboGo_PlastoquinolPlastocyaninreductaseactivity',s("Catalysis","of","the","reaction",":","plastoquinol-1","+","2","oxidized","plastocyanin","=","plastoquinone","+","2","reduced","plastocyanin","."),4259415). assertion_content_comment('oboGo_PlateletActivatingfactoracetyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-radyl-2-acyl-sn-glycero-3-phospholipid","+","1-alkyl-2-acetyl-sn-glycero-3-phosphocholine","=","1-alkyl-2-lyso-sn-glycero-3-phosphocholine","+","1-radyl-2-acetyl-sn-glycero-3-phospholipid","."),4366439). assertion_content_comment('oboGo_PlateletDerivedgrowthfactoralphaReceptoractivity',s("Combining","with","platelet-derived","growth","factor","isoform","PDGF-AA",",","PDGF-BB","or","PDGF-AB","to","initiate","a","change","in","cell","activity","."),4214177). assertion_content_comment('oboGo_PlateletDerivedgrowthfactorbetaReceptoractivity',s("Combining","with","platelet-derived","growth","factor","isoform","PDGF-BB","or","PDGF-AB","to","initiate","a","change","in","cell","activity","."),4214188). assertion_content_comment('oboGo_PlateletDerivedgrowthfactorbinding',s("Interacting","selectively","and","non-covalently","with","platelet-derived","growth","factor","."),4334632). assertion_content_comment('oboGo_PlateletDerivedgrowthfactorproduction',s("The","appearance","of","any","platelet-derived","growth","factor","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4150859). assertion_content_comment('oboGo_PlateletDerivedgrowthfactorreceptoractivity',s("Combining","with","platelet-derived","growth","factor","to","initiate","a","change","in","cell","activity","."),4214173). assertion_content_comment('oboGo_PlateletDerivedgrowthfactorreceptorAlphasignalingpathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","platelet-derived","growth","factor","receptor-alpha","binding","to","one","of","its","physiological","ligands","."),4144566). assertion_content_comment('oboGo_PlateletDerivedgrowthfactorreceptorBetasignalingpathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","platelet-derived","growth","factor","receptor-beta","binding","to","one","of","its","physiological","ligands","."),4144465). assertion_content_comment('oboGo_PlateletDerivedgrowthfactorreceptorbinding',s("Interacting","selectively","and","non-covalently","with","the","platelet-derived","growth","factor","receptor","."),4217208). assertion_content_comment('oboGo_PlateletDerivedgrowthfactorreceptorsignalingpathway',s("The","series","of","molecular","signals","generated","as","a","consequence","of","a","platelet-derived","growth","factor","receptor","binding","to","one","of","its","physiological","ligands","."),4026161). assertion_content_comment('oboGo_PlusEnddirectedmicrofilamentmotoractivity',s("Catalysis","of","movement","along","a","microfilament","towards","the","plus","end",",","coupled","to","the","hydrolysis","of","a","nucleoside","triphosphate","(","usually","ATP",")","The","plus","end","of","an","actin","filament","is","the","end","that","preferentially","adds","actin","monomers","."),4159583). assertion_content_comment('oboGo_PlusEndDirectedmicrotubulemotoractivity',s("Catalysis","of","movement","along","a","microtubule","toward","the","plus","end",",","coupled","to","the","hydrolysis","of","ATP","(","or","GTP",")"),4252578). assertion_content_comment('oboGo_PlusEnddirectedmicrotubulesliding',s("The","movement","of","one","microtubule","along","another","microtubule",",","where","the","motion","is","directed","towards","the","plus","ends","of","the","microtubules","."),4321961). assertion_content_comment('oboGo_PlusEndDirectedorganelletransportalongmicrotubule',s("The","directed","movement","of","an","organelle","towards","the","plus","end","of","a","microtubule",",","mediated","by","motor","proteins",".","This","process","begins","with","the","attachment","of","an","organelle","to","a","microtubule",",","and","ends","when","the","organelle","reaches","its","final","destination","."),4158819). assertion_content_comment('oboGo_PlusEndDirectedvesicletransportalongmicrotubule',s("The","directed","movement","of","a","vesicle","towards","the","plus","end","of","a","microtubule",",","mediated","by","motor","proteins",".","This","process","begins","with","the","attachment","of","a","vesicle","to","a","microtubule",",","and","ends","when","the","vesicle","reaches","its","final","destination","."),4158831). assertion_content_comment('oboGo_PlusEndkinesincomplex',s("Any","complex","that","includes","a","dimer","of","molecules","from","the","kinesin","superfamily","and","any","associated","proteins",",","and","moves","towards","the","plus","end","of","a","microtubule","."),4221547). assertion_content_comment('oboGo_PlusEndspecificmicrotubuledepolymerization',s("The","removal","of","tubulin","heterodimers","from","the","plus","end","of","a","microtubule","."),4176001). assertion_content_comment('oboGo_PMAInduciblemembraneproteinectodomainproteolysis',s("The","proteolytic","cleavage","of","transmembrane","proteins","and","release","of","their","ectodomain","that","occurs","after","induction","by","phorbol-12-myristate-13-acetate","(","PMA",")",",","a","protein","kinase","C","agonist","."),4287137). assertion_content_comment('oboGo_PMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","the","phosphorus","atom","of","an","acceptor","molecule","."),4183508). assertion_content_comment('oboGo_PointedEndactinfilamentcapping',s("The","binding","of","a","protein","or","protein","complex","to","the","pointed","(","or","minus",")","end","of","an","actin","filament",",","thus","preventing","the","addition",",","exchange","or","removal","of","further","actin","subunits","."),4285341). assertion_content_comment('oboGo_PointedEndactinfilamentuncapping',s("The","removal","of","capping","protein","from","the","pointed","(","or","minus",")","end","of","actin","filaments","to","free","the","ends","for","addition",",","exchange","or","removal","of","further","actin","subunits","."),4285382). assertion_content_comment('oboGo_PolarAminoacidTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","polar","amino","acid","(","out",")","=","ADP","+","phosphate","+","polar","amino","acid","(","in",")"),4289812). assertion_content_comment('oboGo_PollenPistilinteraction',s("The","interaction","between","a","pollen","grain","and","pistil","."),4021950). assertion_content_comment('oboGo_Poly3Hydroxyalkanoatebinding',s("Interacting","selectively","and","non-covalently","with","poly","(","3-hydroxyalkanoate",")","s",",","polyesters","of","3-hydroxyacids","produced","as","intracellular","granules","by","a","large","variety","of","bacteria","."),4318391). assertion_content_comment('oboGo_Poly3Hydroxyalkanoatebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","poly","(","3-hydroxyalkanoates",")",",","polyesters","of","3-hydroxyacids","produced","as","intracellular","granules","by","a","large","variety","of","bacteria","."),4093325). assertion_content_comment('oboGo_Poly3Hydroxyalkanoatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","poly","(","3-hydroxyalkanoates",")",",","polyesters","of","3-hydroxyacids","produced","as","intracellular","granules","by","a","large","variety","of","bacteria","."),4093320). assertion_content_comment('oboGo_Poly3Hydroxybutyratedepolymeraseactivity',s("Catalysis","of","the","reaction",":","H2O","+","poly","[","(","R",")","-3-hydroxybutanoate","]","(","n",")","=","poly","[","(","R",")","-3-hydroxybutanoate","]","(","x",")","+","poly","[","(","R",")","-3-hydroxybutanoate","]","(","n-x",")",";","x","=","1-5","."),4269374). assertion_content_comment('oboGo_Poly3Hydroxyoctanoatedepolymeraseactivity',s("Catalysis","of","the","reaction",":","H2O","+","poly","[","(","R",")","-3-hydroxyoctanoate","]","(","n",")","=","poly","[","(","R",")","-3-hydroxyoctanoate","]","(","x",")","+","poly","[","(","R",")","-3-hydroxyoctanoate","]","(","n-x",")",";","x","=","1-5","."),4269242). assertion_content_comment('oboGo_PolyAbinding',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4224097). assertion_content_comment('oboGo_PolyadenylationDependentmrnacatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","messenger","RNA","(","mRNA",")","molecule",",","initiated","by","the","enzymatic","addition","of","a","sequence","of","adenylyl","residues","(","polyadenylation",")","at","the","3","'","end","the","target","mRNA","."),4167198). assertion_content_comment('oboGo_PolyadenylationDependentncrnacatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","noncoding","RNA","(","ncRNA",")","molecule",",","initiated","by","the","enzymatic","addition","of","a","sequence","of","adenylyl","residues","(","polyadenylation",")","at","the","3","'","end","the","target","ncRNA","."),4095149). assertion_content_comment('oboGo_PolyadenylationDependentrnacatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","an","RNA","molecule",",","initiated","by","initiated","by","the","enzymatic","addition","of","a","sequence","of","adenylyl","residues","(","polyadenylation",")","at","the","3","'","-end","of","the","target","RNA","."),4095147). assertion_content_comment('oboGo_PolyadenylationDependentsnorna3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","a","snoRNA","molecule","linked","to","prior","polyadenylation","of","the","3","'","-end","of","the","precursor","snoRNA","."),4167145). assertion_content_comment('oboGo_PolyAdpDRibosebinding',s("Interacting","selectively","and","non-covalently","with","polymeric","ADP-D-ribose",",","a","polymer","that","is","composed","of","poly-ADP-D-ribose","units","linked","through","1",",","2-glycosidic","bonds","at","the","ribose","ring","."),4157739). assertion_content_comment('oboGo_PolyADPRiboseglycohydrolaseactivity',s("Catalysis","of","the","hydrolysis","of","poly","(","ADP-ribose",")","at","glycosidic","(","1","'","'","-2","'",")","linkage","of","ribose-ribose","bond","to","produce","free","ADP-ribose","."),4203420). assertion_content_comment('oboGo_PolyAlphaLGuluronatelyaseactivity',s("Catalysis","of","the","eliminative","cleavage","of","polysaccharides","containing","a","terminal","a-L-guluronate","group",",","to","give","oligopolysaccharides","with","4-deoxy-a-L-erythro-hex-4-enuronosyl","groups","at","their","nonreducing","ends","."),4369234). assertion_content_comment('oboGo_PolyamineTransportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","polyamine","(","out",")","=","ADP","+","phosphate","+","polyamine","(","in",")"),4291432). assertion_content_comment('oboGo_PolyASpecificribonucleaseactivity',s("Catalysis","of","the","exonucleolytic","cleavage","of","poly","(","A",")","to","5","'","-AMP","."),4204885). assertion_content_comment('oboGo_PolyBetaDMannuronatelyaseactivity',s("Catalysis","of","the","eliminative","cleavage","of","polysaccharides","containing","beta-D-mannuronate","residues","to","give","oligosaccharides","with","4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl","groups","at","their","ends","."),4299952). assertion_content_comment('oboGo_Polygalacturonate4AlphaGalacturonosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-D-galacturonate","+","1",",","4-alpha-D-galacturonosyl","(","n",")","=","1",",","4-alpha-D-galacturonosyl","(","n","+","1",")","+","UDP","."),4367051). assertion_content_comment('oboGo_PolyGammaGlutamatebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","poly-gamma-glutamate",",","a","polymer","of","D-","and/or","L-glutamic","acid","residues","linked","by","gamma-peptidyl","bonds","."),4174880). assertion_content_comment('oboGo_PolyGammaGlutamatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","poly-gamma-glutamate",",","a","polymer","of","D-","and/or","L-glutamic","acid","residues","linked","by","gamma-peptidyl","bonds","."),4174869). assertion_content_comment('oboGo_PolyGlutaminetractbinding',s("Interacting","selectively","and","non-covalently","with","a","polyglutamine","tract",",","i.e",".","a","series","of","consecutive","glutamine","residues",",","in","a","protein","."),4256166). assertion_content_comment('oboGo_PolyGlycerolPhosphatealphaGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","poly","(","glycerol","phosphate",")","+","UDP-D-glucose","=","alpha-D-glucosylpoly","(","glycerol","phosphate",")","+","UDP","."),4367090). assertion_content_comment('oboGo_PolyHydroxybutyratebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","poly-hydroxybutyrate","(","PHB",")",",","a","polymer","of","beta-hydroxybutyrate","and","a","common","storage","material","of","prokaryotic","cells","."),4316552). assertion_content_comment('oboGo_PolyHydroxybutyratemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","poly-hydroxybutyrate","(","PHB",")",",","a","polymer","of","beta-hydroxybutyrate","and","a","common","storage","material","of","prokaryotic","cells","."),4316524). assertion_content_comment('oboGo_PolymeraseIIIRegulatoryRegionSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","part","of","a","regulatory","region","that","controls","transcription","by","RNA","polymerase","III",".","The","transcribed","region","might","be","contain","a","single","gene","or","a","cistron","containing","multiple","genes","."),4356517). assertion_content_comment('oboGo_PolyNAcetyllactosaminebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","poly-N-acetyllactosamine",",","a","carbohydrate","composed","of","N-acetyllactosamine","repeats","(","Gal-beta-1",",","4-GlcNAc-beta-1",",","3",")","n","."),4312246). assertion_content_comment('oboGo_PolyNAcetyllactosaminecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","poly-N-acetyllactosamine",",","a","carbohydrate","composed","of","N-acetyllactosamine","repeats","(","Gal-beta-1",",","4-GlcNAc-beta-1",",","3",")","n","."),4312231). assertion_content_comment('oboGo_PolyNAcetyllactosaminemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","poly-N-acetyllactosamine",",","a","carbohydrate","composed","of","N-acetyllactosamine","repeats","(","Gal-beta-1",",","4-GlcNAc-beta-1",",","3",")","n","."),4312218). assertion_content_comment('oboGo_PolyneuridineAldehydeesteraseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","polyneuridine","aldehyde","=","16-epivellosimine","+","CO","(","2",")","+","methanol","."),4269262). assertion_content_comment('oboGo_PolyNMethylPropylamination',s("The","modification","of","peptidyl-lysine","by","the","addition","of","an","N6-propylamino","and","of","propylmethylamino","units",",","forming","N6-","(","propylamino-poly","(","propylmethylamino",")","-propyldimethylamine",")","-L-lysine",",","typical","of","the","silicate","binding","protein","silaffin","."),4285711). assertion_content_comment('oboGo_Polynucleotide3Phosphataseactivity',s("Catalysis","of","the","reaction",":","3","'","-phosphopolynucleotide","+","H2O","=","a","polynucleotide","+","phosphate",".","Hydrolyzes","the","free","3","'","-phosphate","resulting","from","single","strand","breaks","in","DNA","due","to","oxidative","damage","."),4351389). assertion_content_comment('oboGo_Polynucleotide5HydroxylKinaseactivity',s("Catalysis","of","the","reaction",":","NTP","+","5","'","-dephosphopolynucleotide","=","NDP","+","5","'","-phosphopolynucleotide",".","The","polynucleotide","may","be","DNA","or","RNA","."),4280983). assertion_content_comment('oboGo_Polynucleotide5Phosphataseactivity',s("Catalysis","of","the","reaction",":","5","'","-phosphopolynucleotide","+","H2O","=","polynucleotide","+","phosphate","."),4203387). assertion_content_comment('oboGo_PolypeptideNAcetylgalactosaminyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-D-galactosamine","+","polypeptide","=","UDP","+","N-acetyl-D-galactosaminyl-polypeptide",".","This","reaction","is","the","modification","of","serine","or","threonine","residues","in","polypeptide","chains","by","the","transfer","of","a","N-acetylgalactose","from","UDP-N-acetylgalactose","to","the","hydroxyl","group","of","the","amino","acid",";","it","is","the","first","step","in","O-glycan","biosynthesis","."),4203325). assertion_content_comment('oboGo_PolyphosphateGlucosephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","beta-D-glucose","+","long","chain","polyphosphate","=","glucose-6-phosphate","+","long","chain","polyphosphate","."),4368276). assertion_content_comment('oboGo_PolyPurinetractbinding',s("Interacting","selectively","and","non-covalently","with","any","stretch","of","purines","(","adenine","or","guanine",")","in","an","RNA","molecule","."),4176696). assertion_content_comment('oboGo_PolyPyrimidinetractbinding',s("Interacting","selectively","and","non-covalently","with","any","stretch","of","pyrimidines","(","cytosine","or","uracil",")","in","an","RNA","molecule","."),4246208). assertion_content_comment('oboGo_PolyRibitolPhosphatebetaGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","poly","(","ribitol","phosphate",")","+","UDP-D-glucose","=","beta-D-glucosylpoly","(","ribitol","phosphate",")","+","UDP","."),4367103). assertion_content_comment('oboGo_PolyRibitolPhosphatenAcetylglucosaminyltransferaseactivity',s("Catalysis","of","the","reaction",":","poly","(","ribitol","phosphate",")","+","UDP-N-acetyl-D-glucosamine","=","N-acetyl-D-glucosaminyl-poly","(","ribitol","phosphate",")","+","UDP","."),4367142). assertion_content_comment('oboGo_PolysaccharideOMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","1",",","4-N1-D-glucooligosaccharide","=","S-adenosyl-L-homocysteine","+","oligosaccharide","containing","6-methyl-D-glucose","units","."),4308872). assertion_content_comment('oboGo_PolysialicAcidoAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","an","alpha-2",",","8-linked","polymer","of","sialic","acid","=","CoA","+","polysialic","acid","acetylated","at","O-7","or","O-9","."),4264361). assertion_content_comment('oboGo_PolyvinylAlcoholdehydrogenaseacceptoractivity',s("Catalysis","of","the","reaction",":","acceptor","+","polyvinyl","alcohol","=","donor-H2","+","oxidized","polyvinyl","alcohol","."),4364835). assertion_content_comment('oboGo_PolyvinylAlcoholoxidaseactivity',s("Catalysis","of","the","reaction",":","polyvinyl","alcohol","+","O2","=","oxidized","polyvinyl","alcohol","+","H2O2","."),4264375). assertion_content_comment('oboGo_PoreFormingtoxinactivity',s("OBSOLETE",".","Catalysis","of","the","transport","of","electrolytes","and","other","small","molecules","across","a","cell","membrane",".","They","are","synthesized","by","one","cell","and","secreted","for","insertion","into","the","membrane","of","another","cell","where","they","form","transmembrane","pores",".","They","may","exert","their","toxic","effects","by","allowing","the","free","flow","of","electrolytes","and","other","small","molecules","across","the","membrane",",","or","they","may","allow","entry","into","the","target","cell","cytoplasm","of","a","toxin","protein","that","ultimately","kills","the","cell","."),4295180). assertion_content_comment('oboGo_PositiveRegulationByHostOfDefenseRelatedsymbiontmapkinaseMediatedsignaltransductionpathway',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","symbiont","MAP","kinase-mediated","signal","transduction","pathways","during","the","symbiont","defense","response",".","The","symbiont","is","defined","as","the","smaller","of","the","organisms","involved","in","a","symbiotic","interaction","."),4184212). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontAdenylateCyclaseMediatedsignaltransduction',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","adenylate","cyclase-mediated","signal","transduction","in","the","symbiont","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154525). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontCalciumOrCalmodulinMediatedsignaltransduction',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","calcium","or","calmodulin-mediated","signal","transduction","in","the","symbiont","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153275). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontCAMPMediatedsignaltransduction',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","cAMP-mediated","signal","transduction","in","the","symbiont","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153655). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontGProteincoupledreceptorproteinsignaltransduction',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","G-protein","coupled","receptor","protein","signal","transduction",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154024). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontProteinKinaseMediatedsignaltransduction',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","protein","kinase-mediated","signal","transduction","in","the","symbiont","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154374). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontReceptorMediatedsignaltransduction',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","receptor-mediated","signal","transduction","in","the","symbiont",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153997). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontSignalTransductionMediatedByGProteinalphasubunit',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","signal","transduction","mediated","by","G-protein","alpha","subunit",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154037). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontSignalTransductionMediatedByGProteinbetasubunit',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","signal","transduction","mediated","by","G-protein","beta","subunit",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154113). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontSignalTransductionMediatedByGProteingammasubunit',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","symbiont","signal","transduction","mediated","by","G-protein","gamma","subunit",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154134). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontTransmembraneReceptorMediatedcampsignaltransduction',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","transmembrane","receptor-mediated","cAMP","signal","transduction","in","the","symbiont","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154194). assertion_content_comment('oboGo_PositiveRegulationByHostOfSymbiontTransmembraneReceptorMediatedsignaltransduction',s("Any","process","in","which","the","host","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","transmembrane","receptor-mediated","signal","transduction","in","the","symbiont",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154010). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedcalciumDependentproteinkinasepathwayinotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","calcium-dependent","protein","kinase","pathways","that","occur","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196577). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedcalciumionfluxinotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","fluxes","of","calcium","ions","that","occur","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190512). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedcallosedepositioninotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","accumulation","of","callose","that","occurs","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196394). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedcellwallcallosedepositioninotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","deposition","by","a","second","organism","of","callose","in","its","cell","walls",",","occurring","as","part","of","the","defense","response",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196452). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedcellwallthickeninginotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","thickening","of","cell","walls","that","occurs","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4185054). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedethyleneMediatedsignaltransductionpathwayinotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","ethylene-mediated","signal","transduction","pathways","that","occur","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196020). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedjasmonicacidMediatedsignaltransductionpathwayinotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","jasmonic","acid-mediated","signal","transduction","pathways","that","occur","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4196213). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedmapkinaseMediatedsignaltransductionpathwayinotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","MAP","kinase-mediated","signal","transduction","pathways","that","occur","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4184197). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatednitricoxideproductioninotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","production","of","nitric","oxide","that","occurs","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4195857). assertion_content_comment('oboGo_PositiveRegulationByOrganismOfDefenseRelatedreactiveoxygenspeciesproductioninotherorganisminvolvedinsymbioticinteraction',s("Any","process","in","which","an","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","production","of","reactive","oxygen","species","that","occurs","as","part","of","the","defense","response","of","a","second","organism",",","where","the","two","organisms","are","in","a","symbiotic","interaction","."),4190287). 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assertion_content_comment('oboGo_PositiveRegulationOfAdenylateCyclaseActivityByGProteinsignalingpathway',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","adenylate","cyclase","activity","that","is","an","integral","part","of","the","series","of","molecular","signals","generated","as","a","consequence","of","a","G-protein","coupled","receptor","binding","to","its","physiological","ligand",",","resulting","in","a","subsequent","change","in","the","concentration","of","cyclic","AMP","."),4170460). assertion_content_comment('oboGo_PositiveRegulationOfAdultChitinContainingcuticlepigmentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","establishment","of","the","adult","pattern","of","pigmentation","in","the","cuticle","of","an","organism","."),4104117). assertion_content_comment('oboGo_PositiveRegulationOfAlphaBetatcellactivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","alpha-beta","T","cell","activation","."),4069824). assertion_content_comment('oboGo_PositiveRegulationOfAlphaBetatcelldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","alpha-beta","T","cell","differentiation","."),4069836). assertion_content_comment('oboGo_PositiveRegulationOfAlphaBetatcellproliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","alpha-beta","T","cell","proliferation","."),4098928). assertion_content_comment('oboGo_PositiveRegulationOfAntiApoptosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","anti-apoptosis","."),4091114). assertion_content_comment('oboGo_PositiveRegulationOfAntibodyDependentcellularcytotoxicity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","antibody-dependent","cellular","cytotoxicity","."),3984385). assertion_content_comment('oboGo_PositiveRegulationOfAntigenReceptorMediatedsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","pathways","initiated","by","the","cross-linking","of","an","antigen","receptor","on","a","B-","or","T","cell","."),4052399). assertion_content_comment('oboGo_PositiveRegulationOfArp23ComplexMediatedactinnucleation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","Arp2/3","complex-mediated","actin","nucleation","."),4143780). assertion_content_comment('oboGo_PositiveRegulationOfB_1BCellDifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","B-1","B","cell","differentiation","."),3989260). assertion_content_comment('oboGo_PositiveRegulationOfBiosyntheticProcessOfAntibacterialPeptidesActiveAgainstGramNegativebacteria',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","biosynthesis","of","antibacterial","peptides","active","against","Gram-negative","bacteria","."),4011325). assertion_content_comment('oboGo_PositiveRegulationOfBiosyntheticProcessOfAntibacterialPeptidesActiveAgainstGramPositivebacteria',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","biosynthesis","of","antibacterial","peptides","active","against","Gram-positive","bacteria","."),4011343). assertion_content_comment('oboGo_PositiveRegulationOfBloodPressureByEpinephrineNorepinephrine',s("Any","process","in","which","the","force","of","blood","traveling","through","the","circulatory","system","is","increased","by","the","chemicals","epinephrine","and","norepinephrine","."),3991505). assertion_content_comment('oboGo_PositiveRegulationOfBrainDerivedneurotrophicfactorreceptoractivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","brain-derived","neurotrophic","factor","receptor","activity","."),4322132). assertion_content_comment('oboGo_PositiveRegulationOfBrainDerivedneurotrophicfactorreceptorsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","via","the","brain-derived","neurotrophic","factor","receptor","signaling","pathway","."),4060486). assertion_content_comment('oboGo_PositiveRegulationOfCalcidiol1Monooxygenaseactivity',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","calcidiol","1-monooxygenase","activity",".","Calcidiol","1-monooxygenase","activity","is","the","catalysis","of","the","reaction",":","calcidiol","+","NADPH","+","H","+","+","O2","=","calcitriol","+","NADP","+","+","H2O","."),4160684). assertion_content_comment('oboGo_PositiveRegulationOfCalcineurinNfatsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","via","the","calcineurin-NFAT","signaling","pathway","."),4132110). assertion_content_comment('oboGo_PositiveRegulationOfCalciumDependentcellCelladhesion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","calcium-dependent","cell-cell","adhesion","."),4098556). assertion_content_comment('oboGo_PositiveRegulationOfCalciumIndependentcellCelladhesion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","calcium-independent","cell-cell","adhesion","."),4119323). assertion_content_comment('oboGo_PositiveRegulationOfCalciumIonDependentexocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","calcium","ion-dependent","exocytosis","."),4092656). assertion_content_comment('oboGo_PositiveRegulationOfCalciumIonTransportViaStoreOperatedcalciumchannelactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","calcium","ions","via","a","store-operated","calcium","channel","."),4329748). assertion_content_comment('oboGo_PositiveRegulationOfCalciumIonTransportViaVoltageGatedcalciumchannelactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","calcium","ions","via","the","activity","of","voltage-gated","calcium","channels","."),4183029). assertion_content_comment('oboGo_PositiveRegulationOfCalciumMediatedsignaling',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","calcium-mediated","signaling","."),4100729). assertion_content_comment('oboGo_PositiveRegulationOfCalciumOrCalmodulinMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","calcium","or","calmodulin-mediated","signal","transduction","as","a","result","of","detecting","host","molecules","in",",","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152615). assertion_content_comment('oboGo_PositiveRegulationOfCAMPDependentproteinkinaseactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cAMP-dependent","protein","kinase","activity","."),4171687). assertion_content_comment('oboGo_PositiveRegulationOfCAMPMediatedsignalinginresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","cAMP-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152549). assertion_content_comment('oboGo_PositiveRegulationOfCAMPMediatedsignaling',s("Any","process","which","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","cAMP-mediated","signaling",",","a","series","of","molecular","signals","in","which","a","cell","uses","cyclic","AMP","to","convert","an","extracellular","signal","into","a","response","."),4096472). assertion_content_comment('oboGo_PositiveRegulationOfCD4PositivealphaBetatcellactivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CD4-positive",",","alpha-beta","T","cell","activation","."),4069857). assertion_content_comment('oboGo_PositiveRegulationOfCD4PositivealphaBetatcelldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CD4-positive",",","alpha","beta","T","cell","differentiation","."),4069860). assertion_content_comment('oboGo_PositiveRegulationOfCD4PositivealphaBetatcellproliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CD4-positive",",","alpha-beta","T","cell","proliferation","."),4144395). assertion_content_comment('oboGo_PositiveRegulationOfCD4Positivecd25PositivealphaBetaregulatorytcelldifferentiationinvolvedinimmuneresponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","differentiation","of","CD4-positive",",","CD25-positive",",","alpha-beta","regulatory","T","cells","as","part","of","an","immune","response","."),4069913). assertion_content_comment('oboGo_PositiveRegulationOfCD4Positivecd25PositivealphaBetaregulatorytcelldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","differentiation","of","CD4-positive",",","CD25-positive",",","alpha-beta","regulatory","T","cells","."),4069900). assertion_content_comment('oboGo_PositiveRegulationOfCD8PositivealphaBetacytotoxictcellextravasation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CD8-positive",",","alpha-beta","cytotoxic","T","cell","extravasation","."),4142323). assertion_content_comment('oboGo_PositiveRegulationOfCD8PositivealphaBetatcelldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CD8-positive",",","alpha-beta","T","cell","differentiation","."),4095856). assertion_content_comment('oboGo_PositiveRegulationOfCD8PositivealphaBetatcellextravasation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CD8-positive",",","alpha-beta","T","cell","extravasation","."),4142319). assertion_content_comment('oboGo_PositiveRegulationOfCD8PositivealphaBetatcellproliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CD8-positive",",","alpha-beta","T","cell","proliferation","."),4144233). assertion_content_comment('oboGo_PositiveRegulationOfCellCelladhesionmediatedbycadherin',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cell-cell","adhesion","mediated","by","cadherin","."),4139129). assertion_content_comment('oboGo_PositiveRegulationOfCellCelladhesionmediatedbyintegrin',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","cell-cell","adhesion","mediated","by","integrin","."),4063729). assertion_content_comment('oboGo_PositiveRegulationOfCellCelladhesion',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","cell","adhesion","to","another","cell","."),4053506). assertion_content_comment('oboGo_PositiveRegulationOfCellMatrixadhesion',s("Any","process","that","activates","or","increases","the","rate","or","extent","of","cell","adhesion","to","an","extracellular","matrix","."),3988299). assertion_content_comment('oboGo_PositiveRegulationOfCellSubstrateadhesion',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","cell-substrate","adhesion",".","Cell-substrate","adhesion","is","the","attachment","of","a","cell","to","the","underlying","substrate","via","adhesion","molecules","."),3988296). assertion_content_comment('oboGo_PositiveRegulationOfCellularChaperoneMediatedproteincomplexassembly',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","cellular","chaperone-mediated","protein","complex","assembly",".","Cellular","chaperone-mediated","protein","complex","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","protein","complex",",","occurring","at","the","level","of","an","individual","cell",",","mediated","by","chaperone","molecules","that","do","not","form","part","of","the","finished","complex","."),4149786). assertion_content_comment('oboGo_PositiveRegulationOfCGMPMediatedsignaling',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","cGMP-mediated","signaling",".","cGMP-mediated","signaling","is","a","series","of","molecular","signals","in","which","a","cell","uses","cyclic","GMP","to","convert","an","extracellular","signal","into","a","response","."),4024933). assertion_content_comment('oboGo_PositiveRegulationOfChemokineCCmotifligand1production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-C","motif",")","ligand","1","."),4130018). assertion_content_comment('oboGo_PositiveRegulationOfChemokineCCmotifligand4production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-C","motif",")","ligand","4","."),4130156). assertion_content_comment('oboGo_PositiveRegulationOfChemokineCCmotifligand5production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-C","motif",")","ligand","5","."),4130046). assertion_content_comment('oboGo_PositiveRegulationOfChemokineCCmotifligand6production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-C","motif",")","ligand","6","(","CCL6",")"),4084149). assertion_content_comment('oboGo_PositiveRegulationOfChemokineCCmotifligand6secretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","the","regulated","release","of","chemokine","(","C-C","motif",")","ligand","6","(","CCL6",")","from","a","cell","or","group","of","cells","."),4084167). assertion_content_comment('oboGo_PositiveRegulationOfChemokineCXCmotifligand1production',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chemokine","(","C-X-C","motif",")","ligand","1","production","."),4143304). assertion_content_comment('oboGo_PositiveRegulationOfChemokineCXCmotifligand2production',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chemokine","(","C-X-C","motif",")","ligand","2","production","."),4143366). assertion_content_comment('oboGo_PositiveRegulationOfChemokineCXCmotifligand9production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-X-C","motif",")","ligand","9","."),4083254). assertion_content_comment('oboGo_PositiveRegulationOfChemokineMediatedsignalingpathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","series","of","molecular","events","generated","as","a","consequence","of","a","chemokine","binding","to","a","cell","surface","receptor","."),4133066). assertion_content_comment('oboGo_PositiveRegulationOfChemotaxisToCAMPByDIF_2',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","by","the","action","of","DIF-2",".","DIF-2","is","a","chlorinated","alkylphenone","."),4156126). assertion_content_comment('oboGo_PositiveRegulationOfChitinBasedcuticletanning',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","chitin-based","cuticular","tanning","."),4090921). assertion_content_comment('oboGo_PositiveRegulationOfChromatinSilencingAtSilentMatingTypecassette',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","chromatin","silencing","at","silent","mating-type","cassette",".","Chromatin","silencing","at","silent","mating-type","cassette","is","the","repression","of","transcription","at","silent","mating-type","loci","by","altering","the","structure","of","chromatin","."),4150083). assertion_content_comment('oboGo_PositiveRegulationOfChronicInflammatoryResponseToNonAntigenicstimulus',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","chronic","inflammatory","response","to","a","non-antigenic","stimulus","."),4000520). assertion_content_comment('oboGo_PositiveRegulationOfCircadianSleepWakeCycleNonRemsleep',s("Any","process","that","activates","or","increases","the","duration","or","quality","of","non-rapid","eye","movement","(","NREM",")","sleep","."),4091897). assertion_content_comment('oboGo_PositiveRegulationOfClathrinMediatedendocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","clathrin-mediated","endocytosis","."),4142990). assertion_content_comment('oboGo_PositiveRegulationOfCorticotropinReleasinghormonesecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","corticotropin-releasing","hormone","from","a","cell","or","group","of","cells","."),4118419). assertion_content_comment('oboGo_PositiveRegulationOfCyclicNucleotidephosphodiesteraseactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cyclic","nucleotide","phosphodiesterase","activity",",","the","catalysis","of","the","reaction",":","nucleotide","3","'",",","5","'","-cyclic","phosphate","+","H2O","=","nucleotide","5","'","-phosphate","."),4286205). assertion_content_comment('oboGo_PositiveRegulationOfCyclinDependentproteinkinaseactivityinvolveding1s',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CDK","activity","contributing","to","the","G1/S","transition","of","the","cell","cycle","."),4322233). assertion_content_comment('oboGo_PositiveRegulationOfCyclinDependentproteinkinaseactivityinvolveding2m',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CDK","activity","involved","in","the","G2/M","transition","of","the","cell","cycle","."),4322282). assertion_content_comment('oboGo_PositiveRegulationOfCyclinDependentproteinkinaseactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","CDK","activity","."),4297934). assertion_content_comment('oboGo_PositiveRegulationOfCytokineMediatedsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","cytokine","mediated","signaling","pathway","."),3987814). assertion_content_comment('oboGo_PositiveRegulationOfDentineContainingtoothbudformationbymesenchymalEpithelialsignaling',s("Any","process","that","initiates","the","formation","of","a","tooth","bud","by","the","secretion","of","a","signal","from","a","mesenchymal","cell","and","its","reception","and","subsequent","change","in","the","identity","of","an","epithelial","cell","of","the","tooth","bud","."),4161006). assertion_content_comment('oboGo_PositiveRegulationOfDNADependentdnareplicationinitiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","initiation","of","DNA-dependent","DNA","replication","."),4054599). assertion_content_comment('oboGo_PositiveRegulationOfDNADependentdnareplication',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA-dependent","DNA","replication","."),4027856). assertion_content_comment('oboGo_PositiveRegulationOfDNATopoisomeraseATPHydrolyzingactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","topoisomerase","(","ATP-hydrolyzing",")","activity","."),4172484). assertion_content_comment('oboGo_PositiveRegulationOfEndo_14_Beta_XylanaseActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","endo-1",",","4-beta-xylanase","activity",",","the","catalysis","of","the","endohydrolysis","of","1",",","4-beta-D-xylosidic","linkages","in","xylans","."),4286736). assertion_content_comment('oboGo_PositiveRegulationOfERK1AndERK2CascadeViaTNFSF11Mediatedsignaling',s("Any","TNFSF11-mediated","signaling","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","ERK1","and","ERK2","cascade","."),4171025). assertion_content_comment('oboGo_PositiveRegulationOfEstablishmentOfBloodBrainbarrier',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","establishment","of","the","blood-brain","barrier",",","a","selectively","permeable","structural","and","functional","barrier","that","exists","between","the","capillaries","and","the","brain","."),4151480). assertion_content_comment('oboGo_PositiveRegulationOfFastTwitchskeletalmusclefibercontraction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","fast-twitch","skeletal","muscle","contraction","."),4058409). assertion_content_comment('oboGo_PositiveRegulationOfFattyAcidBetaOxidation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","fatty","acid","beta-oxidation","."),4058020). assertion_content_comment('oboGo_PositiveRegulationOfFemaleReceptivityPostMating',s("Any","process","that","increases","the","receptiveness","of","a","female","to","male","advances","subsequent","to","mating","."),4348186). assertion_content_comment('oboGo_PositiveRegulationOfFibronectinDependentthymocytemigration',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","fibronectin-dependent","thymocyte","migration","."),4142821). assertion_content_comment('oboGo_PositiveRegulationOfFollicleStimulatinghormonesecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","follicle-stimulating","hormone","."),4099764). assertion_content_comment('oboGo_PositiveRegulationOfForminNucleatedactincableassembly',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","formin-nucleated","actin","cable","assembly",".","Formin-nucleated","actin","cable","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","formin-nucleated","actin","cable",".","A","formin-nucleated","actin","cable","is","an","actin","filament","bundle","that","consists","of","short","filaments","organized","into","bundles","of","uniform","polarity",",","and","is","nucleated","by","formins","."),4150693). assertion_content_comment('oboGo_PositiveRegulationOfFructose16Bisphosphate1Phosphataseactivity',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","fructose","1",",","6-bisphosphate","1-phosphatase","activity",".","Fructose","1",",","6-bisphosphate","1-phosphatase","activity","is","the","catalysis","of","the","reaction",":","D-fructose","1",",","6-bisphosphate","+","H2O","=","D-fructose","6-phosphate","+","phosphate","."),4160760). assertion_content_comment('oboGo_PositiveRegulationOfFructose16Bisphosphatemetabolicprocess',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","fructose","1",",","6-bisphosphate","metabolism",".","Fructose","1",",","6-bisphosphate","metabolism","is","the","chemical","reactions","and","pathways","involving","fructose","1",",","6-bisphosphate",",","also","known","as","FBP",".","The","D","enantiomer","is","a","metabolic","intermediate","in","glycolysis","and","gluconeogenesis","."),4116423). assertion_content_comment('oboGo_PositiveRegulationOfGammaAminobutyricacidsecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","gamma-aminobutyric","acid","."),4039360). assertion_content_comment('oboGo_PositiveRegulationOfGammaAminobutyricaciduptakeinvolvedintransmissionofnerveimpulse',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","gamma-aminobutyric","acid","(","GABA",",","4-aminobutyrate",")","into","a","neuron","or","glial","cell","."),4120631). assertion_content_comment('oboGo_PositiveRegulationOfGammaDeltatcellactivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","gamma-delta","T","cell","activation","."),4088279). assertion_content_comment('oboGo_PositiveRegulationOfGammaDeltatcelldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","gamma-delta","T","cell","differentiation","."),4088290). assertion_content_comment('oboGo_PositiveRegulationOfGammaDeltatcellproliferation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","gamma-delta","T","cell","proliferation","."),4098975). assertion_content_comment('oboGo_PositiveRegulationOfGeneSpecifictranscriptionelongationfromrnapolymeraseiipromoter',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","gene-specific","RNA","elongation",",","the","extension","of","an","RNA","molecule","from","a","specific","gene","or","genes","after","transcription","initiation","by","the","addition","of","ribonucleotides",",","catalyzed","by","RNA","polymerase","II","."),4154888). assertion_content_comment('oboGo_PositiveRegulationOfGeneSpecifictranscriptionfromrnapolymeraseiipromoter',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","specifically","regulated","synthesis","of","RNA","from","DNA","encoding","a","specific","gene","or","set","of","genes","by","RNA","polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter","."),4013745). assertion_content_comment('oboGo_PositiveRegulationOfGeneSpecifictranscriptioninvolvedinunfoldedproteinresponse',s("The","activation","of","genes","whose","promoters","contain","a","specific","sequence","elements","such","as","the","unfolded","protein","response","element","(","UPRE",";","consensus","CAGCGTG",")","or","the","ER","stress-response","element","(","ERSE",";","CCAAN","(","N",")","9CCACG",")",",","as","a","result","of","signaling","via","the","unfolded","protein","response","."),4013614). assertion_content_comment('oboGo_PositiveRegulationOfGeneSpecifictranscription',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","DNA-dependent","transcription","of","a","specific","gene","or","genes","."),4013588). assertion_content_comment('oboGo_PositiveRegulationOfGlutamateCysteineligaseactivity',s("Any","process","that","activates","or","increases","the","activity","of","glutamate-cysteine","ligase",",","typically","by","lowering","its","sensitivity","to","inhibition","by","glutathione","and","by","increasing","its","affinity","for","glutamate","."),4382606). assertion_content_comment('oboGo_PositiveRegulationOfGProteinalphasubunitMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","G-protein","alpha","subunit-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152300). assertion_content_comment('oboGo_PositiveRegulationOfGProteinbetasubunitMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","G-protein","beta","subunit-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152442). assertion_content_comment('oboGo_PositiveRegulationOfGProteincoupledreceptorproteinsignalingpathwayinresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","G-protein","coupled","receptor","protein-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152295). assertion_content_comment('oboGo_PositiveRegulationOfGProteincoupledreceptorproteinsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","G-protein","coupled","receptor","protein","signaling","pathway","activity","."),4091036). assertion_content_comment('oboGo_PositiveRegulationOfGProteingammasubunitMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","G-protein","gamma","subunit-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152385). assertion_content_comment('oboGo_PositiveRegulationOfGranulocyteColonyStimulatingfactorproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","granulocyte","colony-stimulating","factor","."),4129121). assertion_content_comment('oboGo_PositiveRegulationOfGranulocyteMacrophageColonyStimulatingfactorbiosyntheticprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","granulocyte","macrophage","colony-stimulating","factor","."),4089586). assertion_content_comment('oboGo_PositiveRegulationOfGranulocyteMacrophageColonyStimulatingfactorproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","granulocyte","macrophage","colony-stimulating","factor","production","."),4068279). assertion_content_comment('oboGo_PositiveRegulationOfHeartRateByEpinephrineNorepinephrine',s("The","process","in","which","the","presence","of","epinephrine","or","norepinephrine","in","the","bloodstream","activates",",","maintains","or","increases","the","rate","of","heart","contraction","."),3991592). assertion_content_comment('oboGo_PositiveRegulationOfHeterotypicCellCelladhesion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","heterotypic","cell-cell","adhesion","."),4076723). assertion_content_comment('oboGo_PositiveRegulationOfHighDensitylipoproteinparticleassembly',s("Any","process","that","increases","the","frequency",",","rate",",","or","extent","of","high-density","lipoprotein","particle","assembly",".","High-density","lipoprotein","particle","assembly","is","the","aggregation","and","arrangement","of","proteins","and","lipids","to","form","a","high-density","lipoprotein","particle","."),4150344). assertion_content_comment('oboGo_PositiveRegulationOfHighDensitylipoproteinparticleclearance',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","high-density","lipoprotein","particle","clearance",".","High-density","lipoprotein","particle","clearance","is","the","process","in","which","a","high-density","lipoprotein","particle","is","removed","from","the","blood","via","receptor-mediated","endocytosis","and","its","constituent","parts","degraded","."),4035765). assertion_content_comment('oboGo_PositiveRegulationOfHistoneH3K14acetylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","addition","of","an","acetyl","group","to","histone","H3","at","position","14","of","the","histone","."),4128581). assertion_content_comment('oboGo_PositiveRegulationOfHistoneH3K27methylation',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","histone","H3-K27","methylation",".","Histone","H3-K27","methylation","is","the","modification","of","histone","H3","by","addition","of","a","methyl","group","to","lysine","at","position","27","of","the","histone","."),4135148). assertion_content_comment('oboGo_PositiveRegulationOfHistoneH3K36methylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","covalent","addition","of","a","methyl","group","to","the","lysine","at","position","36","of","histone","H3","."),3975885). assertion_content_comment('oboGo_PositiveRegulationOfHistoneH3K4methylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","covalent","addition","of","a","methyl","group","to","the","lysine","at","position","4","of","histone","H3","."),4121368). assertion_content_comment('oboGo_PositiveRegulationOfHistoneH3K9acetylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","histone","H3-K9","acetylation","."),4143606). assertion_content_comment('oboGo_PositiveRegulationOfHistoneH3K9methylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","covalent","addition","of","a","methyl","group","to","the","lysine","at","position","9","of","histone","H3","."),4121436). assertion_content_comment('oboGo_PositiveRegulationOfHistoneH4K16acetylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","histone","H4-K16","acetylation","."),4144153). assertion_content_comment('oboGo_PositiveRegulationOfHistoneH4K20methylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","covalent","addition","of","a","methyl","group","to","the","lysine","at","position","20","of","histone","H4","."),4131308). assertion_content_comment('oboGo_PositiveRegulationOfHomotypicCellCelladhesion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","homotypic","cell-cell","adhesion","."),4076777). assertion_content_comment('oboGo_PositiveRegulationOfHostSeekingbehavior',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","any","behavior","associated","with","finding","a","host","organism","."),4067315). assertion_content_comment('oboGo_PositiveRegulationOfIKappabkinasenfKappabcascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","an","I-kappaB","kinase/NF-kappaB","induced","cascade","."),4083742). assertion_content_comment('oboGo_PositiveRegulationOfInositol_145_TrisphosphateReceptorActivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","activity","of","the","IP3","receptor","."),4322012). assertion_content_comment('oboGo_PositiveRegulationOfInositolPolyphosphate5Phosphataseactivity',s("Any","process","that","increases","the","rate","or","frequency","of","inositol-polyphosphate","5-phosphatase","activity",",","the","catalysis","of","the","reactions",":","D-myo-inositol","1",",","4",",","5-trisphosphate","+","H2O","=","myo-inositol","1",",","4-bisphosphate","+","phosphate",",","and","1D-myo-inositol","1",",","3",",","4",",","5-tetrakisphosphate","+","H2O","=","1D-myo-inositol","1",",","3",",","4-trisphosphate","+","phosphate","."),4336049). assertion_content_comment('oboGo_PositiveRegulationOfInsulinLikegrowthfactorreceptorsignalingpathway',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","insulin-like","growth","factor","receptor","signaling","."),4094911). assertion_content_comment('oboGo_PositiveRegulationOfInterferonAlphabiosyntheticprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interferon-alpha","."),4085993). assertion_content_comment('oboGo_PositiveRegulationOfInterferonAlphaproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interferon-alpha","production","."),4068312). assertion_content_comment('oboGo_PositiveRegulationOfInterferonBetabiosyntheticprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interferon-beta","."),4084754). assertion_content_comment('oboGo_PositiveRegulationOfInterferonBetaproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interferon-beta","production","."),4068162). assertion_content_comment('oboGo_PositiveRegulationOfInterferonBetasecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interferon-beta","secretion","."),4083830). assertion_content_comment('oboGo_PositiveRegulationOfInterferonGammabiosyntheticprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interferon-gamma","."),4097037). assertion_content_comment('oboGo_PositiveRegulationOfInterferonGammaMediatedsignalingpathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","series","of","molecular","events","generated","as","a","consequence","of","interferon-gamma","binding","to","a","cell","surface","receptor","."),4114685). assertion_content_comment('oboGo_PositiveRegulationOfInterferonGammaproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interferon-gamma","production",".","Interferon-gamma","is","also","known","as","type","II","interferon","."),4068179). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_10BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-10","."),4096904). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_10Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-10","production","."),4069041). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_11BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-11","."),4084889). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_11Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-11","production","."),4069058). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_12BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-12","."),4086388). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_12Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-12","production","."),4069109). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_13BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-13","."),4084932). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_13Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-13","production","."),4069126). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_14BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-14","."),4084992). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_14Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-14","production","."),4069075). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_15BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-15","."),4085052). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_15Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-15","production","."),4069092). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_16BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-16","."),4085112). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_16Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-16","production","."),4069177). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_17BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-17","."),4085168). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_17Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-17","production","."),4069143). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_18BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-18","."),4085211). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_18_MediatedSignalingPathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","interleukin-18-mediated","signaling","pathway","."),4145566). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_18Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-18","production","."),4069160). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_19BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-19","."),4085271). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_19Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-19","production","."),4069228). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1AlphaBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-1","alpha","."),4101642). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1AlphaProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-1","alpha","production","."),4068213). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1AlphaSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","interleukin-1","alpha","from","a","cell","or","group","of","cells","."),4101713). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1BetaBiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-1","beta","."),4101622). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1BetaProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-1","beta","production","."),4068230). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1BetaSecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","interleukin-1","beta","from","a","cell","or","group","of","cells","."),4101752). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-1","."),4084812). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-1","production","."),4068204). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_1Secretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","regulated","release","of","interleukin-1","from","a","cell","or","group","of","cells","."),4101705). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_20BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-20","."),4085390). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_20Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-20","production","."),4069194). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_21BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-21","."),4085450). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_21Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-21","production","."),4069211). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_22BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-22","."),4085510). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_22Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-22","production","."),4069296). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_23BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-23","."),4085549). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_23Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-23","production","."),4069279). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_24BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-24","."),4088961). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_24Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-24","production","."),4069262). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_25BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-25","."),4088675). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_25Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-25","production","."),4069364). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_26BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-26","."),4088620). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_26Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-26","production","."),4069347). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_27BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-27","."),4088730). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_27_MediatedSignalingPathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","series","of","molecular","events","generated","as","a","consequence","of","interleukin-27","binding","to","a","cell","surface","receptor","."),4132967). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_27Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-27","production","."),4069330). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_2BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-2","."),4086448). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_2Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-2","production","."),4069245). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_35BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-35","."),4132754). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_35_MediatedSignalingPathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","series","of","molecular","events","generated","as","a","consequence","of","interleukin-35","binding","to","a","cell","surface","receptor","."),4132845). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_35Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-35","production","."),4132792). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_3BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-3","."),4089398). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_3Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-3","production","."),4069313). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_4BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-4","."),4089355). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_4_DependentIsotypeSwitchingToIgEIsotypes',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","interleukin-4-dependent","isotype","switching","to","IgE","isotypes","."),4144296). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_4Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-4","production","."),4069415). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_5BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-5","."),4089295). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_5Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-5","production","."),4069398). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_6BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-6","."),4089235). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_6_MediatedSignalingPathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","series","of","molecular","events","generated","as","a","consequence","of","interleukin-6","binding","to","a","cell","surface","receptor","."),4132916). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_6Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-6","production","."),4069381). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_7BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-7","."),4089175). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_7Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-7","production","."),4069482). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_8BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-8","."),4089115). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_8Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-8","production","."),4069465). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_8Secretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","interleukin-8","secretion","."),4145789). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_9BiosyntheticProcess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-9","."),4089055). assertion_content_comment('oboGo_PositiveRegulationOfInterleukin_9Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","interleukin-9","production","."),4069448). assertion_content_comment('oboGo_PositiveRegulationOfIP_10Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","IP-10","."),4129251). assertion_content_comment('oboGo_PositiveRegulationOfJAKStatcascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","JAK-STAT","signaling","pathway","activity","."),4078909). assertion_content_comment('oboGo_PositiveRegulationOfLactationByMesenchymalEpithelialcellsignaling',s("The","process","that","increases","the","rate",",","frequency",",","or","extent","of","lactation","as","a","result","of","the","secretion","of","a","signal","from","the","mammary","fat","and","its","reception","by","a","mammary","epithelial","cell","."),4112169). assertion_content_comment('oboGo_PositiveRegulationOfLGlutamatetransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","L-glutamate","transport","."),3990866). assertion_content_comment('oboGo_PositiveRegulationOfLigandDependentnuclearreceptortranscriptioncoactivatoractivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ligand-dependent","nuclear","receptor","transcription","coactivator","activity","."),4169953). assertion_content_comment('oboGo_PositiveRegulationOfLightActivatedchannelactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","light-activated","channel","activity","."),4298173). assertion_content_comment('oboGo_PositiveRegulationOfLipopolysaccharideMediatedsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","in","response","to","detection","of","lipopolysaccharide","."),4056770). assertion_content_comment('oboGo_PositiveRegulationOfLongDayphotoperiodismflowering',s("Any","process","that","activates",",","maintains","or","increases","long-day","photoperiodism",",","where","the","response","associated","with","the","photoperiodism","is","flowering",".","Flowering","is","defined","by","the","switch","from","the","vegetative","to","the","reproductive","phase","."),4106365). assertion_content_comment('oboGo_PositiveRegulationOfLongTermneuronalsynapticplasticity',s("A","process","that","increases","long-term","neuronal","synaptic","plasticity",",","the","ability","of","neuronal","synapses","to","change","long-term","as","circumstances","require",".","Long-term","neuronal","synaptic","plasticity","generally","involves","increase","or","decrease","in","actual","synapse","numbers","."),4385159). assertion_content_comment('oboGo_PositiveRegulationOfLowDensitylipoproteinparticlereceptorbiosyntheticprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","low-density","lipoprotein","receptors","."),4091443). assertion_content_comment('oboGo_PositiveRegulationOfLowDensitylipoproteinparticlereceptorcatabolicprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","low-density","lipoprotein","particle","receptors","."),4070463). assertion_content_comment('oboGo_PositiveRegulationOfMacrophageInflammatoryProtein_1GammaProduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","macrophage","inflammatory","protein-1","gamma","."),4129979). assertion_content_comment('oboGo_PositiveRegulationOfMammaryPlacodeFormationByMesenchymalEpithelialsignaling',s("Any","process","that","initiates","the","formation","of","a","mammary","placode","through","a","mechanism","that","mediates","the","transfer","of","information","from","a","mesenchymal","cell","to","an","epithelial","cell","resulting","in","the","epithelial","cell","adopting","the","identity","of","a","cell","of","the","mammary","placode","."),4111876). assertion_content_comment('oboGo_PositiveRegulationOfMAPKinaseMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","MAP","kinase-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152511). assertion_content_comment('oboGo_PositiveRegulationOfMetanephricMesenchymalCellMigrationByPlateletDerivedgrowthfactorreceptorBetasignalingpathway',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","metanephric","mesenchymal","cell","migration","as","a","result","of","the","series","of","molecular","signals","generated","as","a","consequence","of","a","platelet-derived","growth","factor","receptor-beta","binding","to","one","of","its","physiological","ligands","."),4381335). assertion_content_comment('oboGo_PositiveRegulationOfMethylationDependentchromatinsilencing',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","repression","of","transcription","by","methylation","of","DNA",",","leading","to","the","formation","of","heterochromatin","."),4150728). assertion_content_comment('oboGo_PositiveRegulationOfMinusEndDirectedmicrotubulemotoractivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","minus-end-directed","microtubule","motor","activity","."),4155733). assertion_content_comment('oboGo_PositiveRegulationOfMonocyteChemotacticProtein_1Production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","monocyte","chemotactic","protein-1","."),4130207). assertion_content_comment('oboGo_PositiveRegulationOfMRNA3Endprocessing',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","mRNA","3","'","-end","processing","."),4058221). assertion_content_comment('oboGo_PositiveRegulationOfMultiOrganismprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","a","multi-organism","process",",","a","process","in","which","an","organism","has","an","effect","on","another","organism","of","the","same","or","different","species","."),3985931). assertion_content_comment('oboGo_PositiveRegulationOfMyD88DependenttollLikereceptorsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","MyD88-dependent","toll-like","receptor","signaling","pathway","."),4076937). assertion_content_comment('oboGo_PositiveRegulationOfMyD88IndependenttollLikereceptorsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","MyD88-independent","toll-like","receptor","signaling","pathway","."),4076923). assertion_content_comment('oboGo_PositiveRegulationOfMyosinLightChainPhosphataseactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","myosin-light-chain-phosphatase","activity","."),4379209). assertion_content_comment('oboGo_PositiveRegulationOfNeutrophilMediatedKillingOfGramNegativebacterium',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","gram-negative","bacterium","by","a","neutrophil","."),4131714). assertion_content_comment('oboGo_PositiveRegulationOfNeutrophilMediatedKillingOfGramPositivebacterium',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","directed","killing","of","a","gram-positive","bacterium","by","a","neutrophil","."),4131750). assertion_content_comment('oboGo_PositiveRegulationOfNFKappabimportintonucleus',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transfer","of","NF-kappaB",",","a","transcription","factor","for","eukaryotic","RNA","polymerase","II","promoters",",","from","the","cytoplasm","into","the","nucleus",",","across","the","nuclear","membrane","."),4020199). assertion_content_comment('oboGo_PositiveRegulationOfNFKappabtranscriptionfactoractivitybyeroverloadresponse',s("The","conversion","of","inactive","NF-kappaB","to","the","active","form",",","thereby","allowing","it","to","activate","transcription","of","target","genes",",","as","a","result","of","signaling","from","the","endoplasmic","reticulum","."),4013462). assertion_content_comment('oboGo_PositiveRegulationOfNFKappabtranscriptionfactoractivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","activity","of","the","transcription","factor","NF-kappaB","."),4013456). assertion_content_comment('oboGo_PositiveRegulationOfNitricOxidesynthase2biosyntheticprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","enzyme","nitric","oxide","synthase","2","."),4122057). assertion_content_comment('oboGo_PositiveRegulationOfNitricOxidesynthaseactivity',s("Any","process","that","activates","or","increases","the","activity","of","the","enzyme","nitric-oxide","synthase","."),4279051). assertion_content_comment('oboGo_PositiveRegulationOfNitricOxidesynthasebiosyntheticprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","enzyme","nitric","oxide","synthase","."),4122106). assertion_content_comment('oboGo_PositiveRegulationOfNonCanonicalwntreceptorsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","non-canonical","Wnt","receptor","signaling","pathway","."),4090538). assertion_content_comment('oboGo_PositiveRegulationOfNonProfessionalantigenpresentingcellantigenprocessingandpresentation',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","non-professional","antigen","presenting","cell","antigen","processing","and","presentation","."),3994502). assertion_content_comment('oboGo_PositiveRegulationOfNuclearTranscribedmrnacatabolicprocessnonsenseMediateddecay',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","nuclear-transcribed","mRNA","catabolic","process",",","nonsense-mediated","decay","."),4144094). assertion_content_comment('oboGo_PositiveRegulationOfNuclearTranscribedmrnapolyatailshortening',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","poly","(","A",")","tail","shortening","of","a","nuclear-transcribed","mRNA",".","Poly","(","A",")","tail","shortening","is","the","decrease","in","length","of","the","poly","(","A",")","tail","of","an","mRNA","from","full","length","to","an","oligo","(","A",")","length","."),4115470). assertion_content_comment('oboGo_PositiveRegulationOfNucleotideBindingoligomerizationdomaincontaining1signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","the","nucleotide-binding","oligomerization","domain","containing","1","(","NOD1",")","pathway","."),4136513). assertion_content_comment('oboGo_PositiveRegulationOfNucleotideBindingoligomerizationdomaincontaining2signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","the","nucleotide-binding","oligomerization","domain","containing","2","(","NOD2",")","pathway","."),4136464). assertion_content_comment('oboGo_PositiveRegulationOfNucleotideBindingoligomerizationdomaincontainingsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","the","nucleotide-binding","oligomerization","domain","containing","(","NOD",")","pathway","."),4136458). assertion_content_comment('oboGo_PositiveRegulationOfOdontogenesisOfDentineContainingtooth',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","formation","and","development","of","teeth",",","the","hard",",","bony","appendages","that","are","borne","on","the","jaws",",","or","on","other","bones","in","the","walls","of","the","mouth","or","pharynx","of","most","vertebrates","."),4078609). assertion_content_comment('oboGo_PositiveRegulationOfPathwayRestrictedsmadproteinphosphorylation',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","pathway-restricted","SMAD","protein","phosphorylation",".","Pathway-restricted","SMAD","proteins","and","common-partner","SMAD","proteins","are","involved","in","the","transforming","growth","factor","beta","receptor","signaling","pathways","."),4037093). assertion_content_comment('oboGo_PositiveRegulationOfPeptidylCysteinesNitrosylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","peptidyl-cysteine","S-nitrosylation","."),4141584). assertion_content_comment('oboGo_PositiveRegulationOfPeptidylSerinephosphorylationofstatprotein',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","phosphorylation","of","a","serine","residue","of","a","STAT","(","Signal","Transducer","and","Activator","of","Transcription",")","protein","."),4347917). assertion_content_comment('oboGo_PositiveRegulationOfPeptidylSerinephosphorylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","phosphorylation","of","peptidyl-serine","."),4065543). assertion_content_comment('oboGo_PositiveRegulationOfPeptidylThreoninephosphorylation',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","peptidyl-threonine","phosphorylation",".","Peptidyl-threonine","phosphorylation","is","the","phosphorylation","of","peptidyl-threonine","to","form","peptidyl-O-phospho-L-threonine","."),4025787). assertion_content_comment('oboGo_PositiveRegulationOfPeptidylTyrosinephosphorylation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","phosphorylation","of","peptidyl-tyrosine","."),4027174). assertion_content_comment('oboGo_PositiveRegulationOfPheromoneDependentsignaltransductioninvolvedinconjugationwithcellularfusion',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","pheromone-dependent","signal","transduction","during","conjugation","with","cellular","fusion",",","a","signal","transduction","process","resulting","in","the","relay",",","amplification","or","dampening","of","a","signal","generated","in","response","to","pheromone","exposure","in","organisms","that","undergo","conjugation","with","cellular","fusion","."),4149740). assertion_content_comment('oboGo_PositiveRegulationOfPhosphatidylinositol3Kinaseactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","phosphatidylinositol","3-kinase","activity","."),4325493). assertion_content_comment('oboGo_PositiveRegulationOfPhosphatidylinositol3Kinasecascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","phosphatidylinositol","3-kinase","cascade","."),4039958). assertion_content_comment('oboGo_PositiveRegulationOfPlantTypehypersensitiveresponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","hypersensitive","response","in","a","plant","."),4077070). assertion_content_comment('oboGo_PositiveRegulationOfPlasmaKallikreinKinincascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","the","plasma","kallikrein-kinin","cascade","."),3996652). assertion_content_comment('oboGo_PositiveRegulationOfPlasmaMembraneLongChainfattyacidtransport',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","plasma","membrane","long-chain","fatty","acid","transport",".","Plasma","membrane","long-chain","fatty","acid","transport","is","the","directed","movement","of","long-chain","fatty","acids","across","the","plasma","membrane","."),4024819). assertion_content_comment('oboGo_PositiveRegulationOfPlateletDerivedgrowthfactorproduction',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","the","appearance","of","any","platelet-derived","growth","factor","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4150938). assertion_content_comment('oboGo_PositiveRegulationOfPlateletDerivedgrowthfactorreceptorAlphasignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","platelet-derived","growth","factor","receptor-alpha","signaling","pathway","."),4144609). assertion_content_comment('oboGo_PositiveRegulationOfPlateletDerivedgrowthfactorreceptorBetasignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","platelet-derived","growth","factor","receptor-beta","signaling","pathway","."),4144508). assertion_content_comment('oboGo_PositiveRegulationOfPlateletDerivedgrowthfactorreceptorsignalingpathway',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","platelet-derived","growth","factor","receptor","signaling","pathway","."),4026198). assertion_content_comment('oboGo_PositiveRegulationOfPlusEndDirectedmicrotubulemotoractivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","plus-end-directed","microtubule","motor","activity","."),4155798). assertion_content_comment('oboGo_PositiveRegulationOfPositiveChemotaxisToCAMPByDIF_1',s("Any","process","that","increases","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","by","the","action","of","DIF-1",".","DIF-1","is","a","chlorinated","alkylphenone","."),4156136). assertion_content_comment('oboGo_PositiveRegulationOfPostEmbryonicdevelopment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","post-embryonic","development",".","Post-embryonic","development","is","defined","as","the","process","whose","specific","outcome","is","the","progression","of","the","organism","over","time",",","from","the","completion","of","embryonic","development","to","the","mature","structure","."),4021305). assertion_content_comment('oboGo_PositiveRegulationOfPreMicrornaprocessing',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","pre-microRNA","processing","."),4143945). assertion_content_comment('oboGo_PositiveRegulationOfProstaglandinEndoperoxidesynthaseactivity',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","prostaglandin-endoperoxide","synthase","activity",".","Prostaglandin-endoperoxide","synthase","activity","is","the","catalysis","of","the","reaction",":","arachidonate","+","donor-H2","+","2","O2","=","prostaglandin","H2","+","acceptor","+","H2O","."),4160802). assertion_content_comment('oboGo_PositiveRegulationOfProstaglandinEsynthaseactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","prostaglandin-E","synthase","activity","."),4172562). assertion_content_comment('oboGo_PositiveRegulationOfProTcelldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","pro-T","cell","differentiation","."),4141451). assertion_content_comment('oboGo_PositiveRegulationOfProteasomalUbiquitinDependentproteincatabolicprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds",",","initiated","by","the","covalent","attachment","of","ubiquitin",",","and","mediated","by","the","proteasome","."),4012135). assertion_content_comment('oboGo_PositiveRegulationOfProteinUbiquitinationInvolvedInUbiquitinDependentproteincatabolicprocess',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","protein","ubiquitination","involved","in","ubiquitin-dependent","protein","catabolic","process","."),4138772). assertion_content_comment('oboGo_PositiveRegulationOfReceptorMediatedendocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","receptor","mediated","endocytosis",",","the","uptake","of","external","materials","by","cells",",","utilizing","receptors","to","ensure","specificity","of","transport","."),3992670). assertion_content_comment('oboGo_PositiveRegulationOfReceptorMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","receptor-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152287). assertion_content_comment('oboGo_PositiveRegulationOfRedOrFarRedlightsignalingpathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","the","red","or","far-red","signaling","pathway",",","the","series","of","molecular","signals","initiated","upon","sensing","by","photoreceptor","molecules","of","red","light","or","far","red","light","."),4151665). assertion_content_comment('oboGo_PositiveRegulationOfResponseToInterferonGamma',s("Any","process","that","decreases","the","rate",",","frequency","or","extent","of","a","response","to","interferon-gamma",".","Response","to","interferon","gamma","is","a","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","an","interferon-gamma","stimulus","."),4114677). assertion_content_comment('oboGo_PositiveRegulationOfRyanodineSensitivecalciumReleasechannelactivity',s("Any","process","that","increases","the","activity","of","a","ryanodine-sensitive","calcium-release","channel",".","The","ryanodine-sensitive","calcium-release","channel","catalyzes","the","transmembrane","transfer","of","a","calcium","ion","by","a","channel","that","opens","when","a","ryanodine","class","ligand","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4160442). assertion_content_comment('oboGo_PositiveRegulationOfSalivaryGlandFormationByMesenchymalEpithelialsignaling',s("Any","process","that","induces","the","formation","of","the","salivary","gland","field","by","means","of","the","secretion","of","a","signal","by","a","mesenchymal","cell","and","its","reception","and","interpretation","by","an","epithelial","cell","resulting","in","it","adopting","the","identity","of","a","salivary","gland","bud","cell","."),4112116). assertion_content_comment('oboGo_PositiveRegulationOfSequenceSpecificdnabindingtranscriptionfactoractivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","activity","of","a","transcription","factor",",","any","factor","involved","in","the","initiation","or","regulation","of","transcription","."),4013448). assertion_content_comment('oboGo_PositiveRegulationOfShortDayphotoperiodismflowering',s("Any","process","that","activates",",","maintains","or","increases","short-day","photoperiodism",",","where","the","response","associated","with","the","photoperiodism","is","flowering",".","Flowering","is","defined","by","the","switch","from","the","vegetative","to","the","reproductive","phase","."),4106309). assertion_content_comment('oboGo_PositiveRegulationOfShortTermneuronalsynapticplasticity',s("A","process","that","increases","short-term","neuronal","synaptic","plasticity",",","the","ability","of","neuronal","synapses","to","change","in","the","short-term","as","circumstances","require",".","Short-term","neuronal","synaptic","plasticity","generally","involves","increasing","or","decreasing","synaptic","sensitivity","."),4385128). assertion_content_comment('oboGo_PositiveRegulationOfSingleStrandedtelomericdnabinding',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","single-stranded","telomeric","DNA","binding","."),4160181). assertion_content_comment('oboGo_PositiveRegulationOfSlowTwitchskeletalmusclefibercontraction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","slow-twitch","skeletal","muscle","contraction","."),4058329). assertion_content_comment('oboGo_PositiveRegulationOfSodiumDependentphosphatetransport',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","sodium-dependent","phosphate","transport","."),4137941). assertion_content_comment('oboGo_PositiveRegulationOfSodiumIonTransportViaVoltageGatedsodiumchannelactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","directed","movement","of","sodium","ions","via","the","activity","of","voltage-gated","sodium","channels","."),4155019). assertion_content_comment('oboGo_PositiveRegulationOfSporeBearingorgandevelopment',s("Any","process","that","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","spore-bearing","organ","development",",","a","process","in","which","hyphae","grow","into","special","aggregates","called","fruiting","bodies","that","produce","new","spores","."),4059648). assertion_content_comment('oboGo_PositiveRegulationOfSREBPMediatedsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","SREBP-mediated","signaling","pathway","."),4137657). assertion_content_comment('oboGo_PositiveRegulationOfStressActivatedmapkcascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","stress-activated","MAPK","cascade","."),4070213). assertion_content_comment('oboGo_PositiveRegulationOfStressActivatedproteinkinasesignalingcascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signaling","via","the","stress-activated","protein","kinase","signaling","cascade","."),4070202). assertion_content_comment('oboGo_PositiveRegulationOfSymbiontAdenylateCyclaseMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","adenylate","cyclase-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4154591). assertion_content_comment('oboGo_PositiveRegulationOfSymbiontProteinKinaseMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","protein","kinase-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152420). assertion_content_comment('oboGo_PositiveRegulationOfTelomereMaintenanceViaSemiConservativereplication',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","the","semi-conservative","replication","of","telomeric","DNA","."),4054135). assertion_content_comment('oboGo_PositiveRegulationOfTheForceOfHeartContractionByCirculatingEpinephrineNorepinephrine',s("Any","process","that","increases","the","force","with","which","the","cardiac","muscles","of","the","heart","pump","blood","through","the","circulatory","system","as","a","result","of","the","presence","of","epinephrine","or","norepinephrine","in","the","bloodstream","."),4003964). assertion_content_comment('oboGo_PositiveRegulationOfTheForceOfHeartContractionByEpinephrineNorepinephrine',s("Any","process","that","increases","the","force","with","which","the","cardiac","muscles","of","the","heart","pump","blood","through","the","circulatory","system","as","a","result","of","the","presence","of","epinephrine","or","norepinephrine","in","the","bloodstream","or","released","from","the","nerve","endings","."),3991566). assertion_content_comment('oboGo_PositiveRegulationOfTheForceOfHeartContractionByNeuronalEpinephrineNorepinephrine',s("Any","process","that","increases","the","force","with","which","the","cardiac","muscles","of","the","heart","pump","blood","through","the","circulatory","system","as","a","result","of","the","presence","of","epinephrine","or","norepinephrine","released","from","the","nerve","endings","."),4003992). assertion_content_comment('oboGo_PositiveRegulationOfTHelper17celldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","17","cell","differentiation","."),4139662). assertion_content_comment('oboGo_PositiveRegulationOfTHelper17cellextravasation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","17","cell","extravasation","."),4142190). assertion_content_comment('oboGo_PositiveRegulationOfTHelper17celllineagecommitment',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","17","cell","lineage","commitment","."),4143102). assertion_content_comment('oboGo_PositiveRegulationOfTHelper17typeimmuneresponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","17","type","immune","response","."),4139722). assertion_content_comment('oboGo_PositiveRegulationOfTHelper1cellactivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","1","cell","activation","."),4144831). assertion_content_comment('oboGo_PositiveRegulationOfTHelper1cellcytokineproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","1","cell","cytokine","production","."),4145089). assertion_content_comment('oboGo_PositiveRegulationOfTHelper1celldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","1","cell","differentiation","."),4086775). assertion_content_comment('oboGo_PositiveRegulationOfTHelper1typeimmuneresponse',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","a","T-helper","1","type","immune","response","."),4000721). assertion_content_comment('oboGo_PositiveRegulationOfTHelper2cellactivation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","2","cell","activation","."),4144308). assertion_content_comment('oboGo_PositiveRegulationOfTHelper2cellcytokineproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","2","cell","cytokine","production","."),4144992). assertion_content_comment('oboGo_PositiveRegulationOfTHelper2celldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","2","cell","differentiation","."),4086810). assertion_content_comment('oboGo_PositiveRegulationOfTHelpercelldifferentiation',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","T-helper","cell","differentiation","."),4086752). assertion_content_comment('oboGo_PositiveRegulationOfThyroidStimulatinghormonesecretion',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","thyroid-stimulating","hormone","secretion","."),4143656). assertion_content_comment('oboGo_PositiveRegulationOfTissueKallikreinKinincascade',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","the","tissue","kallikrein-kinin","cascade","."),3996620). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor10signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","10","signaling","pathway","."),4075952). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor11signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","11","signaling","pathway","."),4075889). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor12signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","12","signaling","pathway","."),4076146). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor13signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","13","signaling","pathway","."),4076120). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor15signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","toll-like","receptor","15","signaling","pathway","."),4141945). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor1signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","1","signaling","pathway","."),4076986). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor21signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","toll-like","receptor","21","signaling","pathway","."),4142416). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor2signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","2","signaling","pathway","."),4076244). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor3signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","3","signaling","pathway","."),4076329). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor4signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","4","signaling","pathway","."),4076280). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor5signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","5","signaling","pathway","."),4076427). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor6signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","6","signaling","pathway","."),4076365). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor7signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","7","signaling","pathway","."),4076502). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor8signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","8","signaling","pathway","."),4076551). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptor9signalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","9","signaling","pathway","."),4076489). assertion_content_comment('oboGo_PositiveRegulationOfTollLikereceptorsignalingpathway',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","signaling","pathway","."),4075871). assertion_content_comment('oboGo_PositiveRegulationOfTranscriptionDNADependent',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","cellular","DNA-dependent","transcription","."),4012780). assertion_content_comment('oboGo_PositiveRegulationOfTranscriptionElongationDNADependent',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","elongation",",","the","extension","of","an","RNA","molecule","after","transcription","initiation","and","promoter","clearance","by","the","addition","of","ribonucleotides","catalyzed","by","a","DNA-dependent","RNA","polymerase","."),4065312). assertion_content_comment('oboGo_PositiveRegulationOfTranscriptionInitiationDNADependent',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA-dependent","transcription","initiation","."),4116012). assertion_content_comment('oboGo_PositiveRegulationOfTranscriptionInvolvedInG2MPhaseofmitoticcellcycle',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","transcription","of","target","genes","that","are","transcribed","as","part","of","the","G2/M","phase","of","the","mitotic","cell","cycle","."),4155427). assertion_content_comment('oboGo_PositiveRegulationOfTranscriptionMatingTypespecific',s("Any","mating-type","specific","process","that","activates","or","increases","the","rate","of","transcription","."),4298281). assertion_content_comment('oboGo_PositiveRegulationOfTranscriptionTerminationDNADependent',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","DNA-dependent","transcription","termination",",","the","process","in","which","transcription","is","completed",";","the","formation","of","phosphodiester","bonds","ceases",",","the","RNA-DNA","hybrid","dissociates",",","and","RNA","polymerase","releases","the","DNA","."),4117200). assertion_content_comment('oboGo_PositiveRegulationOfTranscriptionViaSterolRegulatoryElementBindingInvolvedInERNuclearsterolresponsepathway',s("The","process","in","which","a","sterol","regulatory","element","binding","protein","(","SREBP",")","mediates","an","increase","in","rate","or","extent","of","transcription","of","nuclear","target","genes","in","response","to","sterol","depletion",".","SREBPs","are","transcription","factors","that","bind","sterol","regulatory","elements","(","SREs",")",",","DNA","motifs","found","in","the","promoters","of","target","genes","."),4013759). assertion_content_comment('oboGo_PositiveRegulationOfTransformingGrowthFactorBeta1production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","transforming","growth","factor-beta1","."),4064397). assertion_content_comment('oboGo_PositiveRegulationOfTransformingGrowthFactorBeta2production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","transforming","growth","factor-beta2","."),4064415). assertion_content_comment('oboGo_PositiveRegulationOfTransformingGrowthFactorBeta3production',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","transforming","growth","factor-beta3","."),4064433). assertion_content_comment('oboGo_PositiveRegulationOfTransformingGrowthFactorBetaproduction',s("Any","process","that","activates","or","increases","the","frequency",",","rate",",","or","extent","of","production","of","transforming","growth","factor-beta","."),4064390). assertion_content_comment('oboGo_PositiveRegulationOfTranslationNcRNAMediated',s("Any","process",",","mediated","by","small","non-coding","RNAs",",","that","activates","or","increases","the","rate","that","mRNAs","are","effectively","translated","into","protein","."),4297977). assertion_content_comment('oboGo_PositiveRegulationOfTransmembraneReceptorMediatedcampsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","transmembrane","receptor-mediated","cAMP","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4153602). assertion_content_comment('oboGo_PositiveRegulationOfTransmembraneReceptorMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","activates",",","maintains","or","increases","the","frequency",",","rate","or","extent","of","its","transmembrane","receptor-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152291). assertion_content_comment('oboGo_PositiveRegulationOfTranspositionDNAMediated',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","DNA","transposition","."),3975376). assertion_content_comment('oboGo_PositiveRegulationOfTranspositionRNAMediated',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","RNA-mediated","transposition",".","RNA-mediated","transposition","is","a","type","of","transpositional","recombination","which","occurs","via","an","RNA","intermediate","."),4029884). assertion_content_comment('oboGo_PositiveRegulationOfTwoComponentsignaltransductionsystemphosphorelay',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","signal","transduction","via","a","two-component","phosphorelay","signal","transduction","system","."),4137352). assertion_content_comment('oboGo_PositiveRegulationOfTypeIInterferonMediatedsignalingpathway',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","a","type","I","interferon-mediated","signaling","pathway",".","A","type","I","interferon-mediated","signaling","pathway","is","the","series","of","molecular","events","generated","as","a","consequence","of","a","type","I","interferon","binding","to","a","cell","surface","receptor","."),4114565). assertion_content_comment('oboGo_PositiveRegulationOfUbiquitinDependentendocytosis',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ubiquitin-dependent","endocytosis","."),4142520). assertion_content_comment('oboGo_PositiveRegulationOfUbiquitinProteinligaseactivityinvolvedinmeioticcellcycle',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","ubiquitin","ligase","activity","during","the","meiotic","cell","cycle","."),4286360). assertion_content_comment('oboGo_PositiveRegulationOfUbiquitinProteinligaseactivityinvolvedinmitoticcellcycle',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","ubiquitin","ligase","activity","that","contributes","to","the","mitotic","cell","cycle","."),4012415). assertion_content_comment('oboGo_PositiveRegulationOfUbiquitinProteinligaseactivity',s("Any","process","that","activates",",","maintains","or","increases","the","rate","of","ubiquitin","ligase","activity",",","the","catalysis","of","the","reaction",":","ATP","+","ubiquitin","+","protein","lysine","=","AMP","+","diphosphate","+","protein","N-ubiquityllysine","."),4012401). assertion_content_comment('oboGo_PositiveRegulationOfUbiquitinSpecificproteaseactivity',s("Any","process","that","activates","or","increases","the","frequency",",","rate","or","extent","of","ubiquitin-specific","protease","activity","."),4170418). assertion_content_comment('oboGo_PositiveRegulationOfVacuoleFusionNonAutophagic',s("Any","process","that","increases","the","frequency",",","rate","or","extent","of","the","fusion","of","two","vacuole","membranes","to","form","a","single","vacuole","."),4136118). assertion_content_comment('oboGo_PositiveRegulationOfVeryLowDensitylipoproteinparticleremodeling',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","very-low-density","lipoprotein","particle","remodeling",".","Very-low-density","lipoprotein","particle","remodeling","is","the","acquisition",",","loss","or","modification","of","a","protein","or","lipid","within","a","very-low-density","lipoprotein","particle",",","including","the","hydrolysis","of","triglyceride","by","hepatic","lipase","or","lipoprotein","lipase","and","the","subsequent","loss","of","free","fatty","acid","."),4038071). assertion_content_comment('oboGo_PositiveRegulationOfVitaminD24Hydroxylaseactivity',s("Any","process","that","increases","the","rate",",","frequency","or","extent","of","vitamin","D","24-hydroxylase","activity",".","Vitamin","D","24-hydroxylase","activity","catalyzes","the","hydroxylation","of","C-24","of","any","form","of","vitamin","D","."),4336866). assertion_content_comment('oboGo_PostChaperonintubulinfoldingpathway',s("Completion","of","folding","of","alpha-","and","beta-tubulin",";","takes","place","subsequent","to","chaperonin-mediated","partial","folding",";","mediated","by","a","complex","of","folding","cofactors","."),4013197). assertion_content_comment('oboGo_PostEmbryonicanalfinmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","anal","fin","are","generated","and","organized",".","An","anal","fin","is","an","unpaired","medial","fin","on","the","ventral","aspect","near","the","caudal","end","of","a","fish",",","which","provides","lateral","stability","while","swimming","."),4382230). assertion_content_comment('oboGo_PostEmbryonicanteriormidgutectodermalmorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","anterior","midgut","(","ectodermal",")","are","generated","and","organized",",","during","the","post-embryonic","phase","."),4106516). assertion_content_comment('oboGo_PostEmbryonicappendagemorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","an","appendage","are","generated","and","organized",".","An","appendage","is","an","organ","or","part","that","is","attached","to","the","trunk","of","an","organism",",","such","as","a","limb","or","a","branch","."),3982476). assertion_content_comment('oboGo_PostEmbryonicbodymorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","post-embryonic","soma","are","generated","and","organized","."),4232519). assertion_content_comment('oboGo_PostEmbryoniccameraTypeeyedevelopment',s("The","process","occurring","during","the","post-embryonic","phase","whose","specific","outcome","is","the","progression","of","the","camera-type","eye","over","time",",","from","its","formation","to","the","mature","structure","."),4062827). assertion_content_comment('oboGo_PostEmbryoniccameraTypeeyemorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","eye","are","generated","and","organized","during","post-embryonic","development","."),4106408). assertion_content_comment('oboGo_PostEmbryoniccardiacmusclecellgrowthinvolvedinheartmorphogenesis',s("The","growth","of","a","cardiac","muscle","cell","during","the","postembryonic","period","that","contributes","to","the","shaping","of","the","heart","."),4002923). assertion_content_comment('oboGo_PostEmbryoniccaudalfinmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","caudal","fin","are","generated","and","organized",".","The","caudal","fin","is","an","unpaired","medial","fin","mounted","at","the","caudal","end","of","the","fish","and","is","the","main","fin","used","for","propulsion","."),4382220). assertion_content_comment('oboGo_PostEmbryonicdevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","organism","over","time",",","from","the","completion","of","embryonic","development","to","the","mature","structure",".","See","embryonic","development","."),3982470). assertion_content_comment('oboGo_PostEmbryonicdigestivetractmorphogenesis',s("The","process",",","occurring","during","the","post-embryonic","phase",",","by","which","the","anatomical","structures","of","the","digestive","tract","are","generated","and","organized",".","The","digestive","tract","is","the","anatomical","structure","through","which","food","passes","and","is","processed","."),4106510). assertion_content_comment('oboGo_PostEmbryonicdorsalfinmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","dorsal","fin","are","generated","and","organized",".","A","dorsal","fin","is","an","unpaired","medial","fin","on","the","dorsal","aspect","of","a","fish","that","provides","lateral","stability","while","swimming",".","Generally","fish","have","one","or","two","dorsal","fins","."),4382210). assertion_content_comment('oboGo_PostEmbryonicectodermaldigestivetractdevelopment',s("The","process",",","occurring","during","the","post-embryonic","phase",",","whose","specific","outcome","is","the","progression","of","the","ectodermal","gut","over","time",",","from","its","formation","to","the","mature","structure","."),4106498). assertion_content_comment('oboGo_PostEmbryonicectodermaldigestivetractmorphogenesis',s("The","process",",","occurring","during","the","post-embryonic","phase",",","by","which","the","anatomical","structures","of","the","ectodermal","gut","are","generated","and","organized","."),4106513). assertion_content_comment('oboGo_PostEmbryoniceyemorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","eye","are","generated","and","organized",".","The","eye","is","the","organ","of","sight","."),4106404). assertion_content_comment('oboGo_PostEmbryonicforegutmorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","foregut","are","generated","and","organized",",","during","the","post-embryonic","phase","."),4106546). assertion_content_comment('oboGo_PostEmbryonicforelimbmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","forelimb","are","generated","and","organized",".","The","forelimbs","are","the","front","limbs","of","an","organism","."),4382166). assertion_content_comment('oboGo_PostEmbryonicgenitaliamorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","genitalia","are","generated","and","organized","."),4105316). assertion_content_comment('oboGo_PostEmbryonichemopoiesis',s("The","stages","of","blood","cell","formation","that","take","place","after","completion","of","embryonic","development","."),4071757). assertion_content_comment('oboGo_PostEmbryonichindgutmorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","hindgut","are","generated","and","organized",",","during","the","post-embryonic","phase","."),4106526). assertion_content_comment('oboGo_PostEmbryonichindlimbmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","hindlimb","are","generated","and","organized","."),4382197). assertion_content_comment('oboGo_PostEmbryoniclimbmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","limb","are","generated","and","organized",".","A","limb","is","an","appendage","of","an","animal","used","for","locomotion","or","grasping","."),4018165). assertion_content_comment('oboGo_PostEmbryonicmedialfinmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","medial","fin","are","generated","and","organized",".","Medial","fins","are","unpaired","fins","of","fish",",","usually","located","dorsomedially","or","ventromedially","and","primarily","used","for","stability","while","swimming","."),4382179). assertion_content_comment('oboGo_PostEmbryonicmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","anatomical","structures","are","generated","and","organized","."),3982472). assertion_content_comment('oboGo_PostEmbryonicorgandevelopment',s("Development",",","taking","place","during","the","post-embryonic","phase",",","of","a","tissue","or","tissues","that","work","together","to","perform","a","specific","function","or","functions",".","Development","pertains","to","the","process","whose","specific","outcome","is","the","progression","of","a","structure","over","time",",","from","its","formation","to","the","mature","structure",".","Organs","are","commonly","observed","as","visibly","distinct","structures",",","but","may","also","exist","as","loosely","associated","clusters","of","cells","that","work","together","to","perform","a","specific","function","or","functions","."),3982510). assertion_content_comment('oboGo_PostEmbryonicorganmorphogenesis',s("Morphogenesis",",","during","the","post-embryonic","phase",",","of","a","tissue","or","tissues","that","work","together","to","perform","a","specific","function","or","functions",".","Morphogenesis","pertains","to","process","in","which","anatomical","structures","are","generated","and","organized",".","Organs","are","commonly","observed","as","visibly","distinct","structures",",","but","may","also","exist","as","loosely","associated","clusters","of","cells","that","work","together","to","perform","a","specific","function","or","functions","."),3982513). assertion_content_comment('oboGo_PostEmbryonicpectoralfinmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","pectoral","fin","are","generated","and","organized",".","Pectoral","fins","are","bilaterally","paired","fins","mounted","laterally","and","located","behind","the","gill","covers","of","fish",".","These","fins","are","used","for","lateral","mobility","and","propulsion","."),4382169). assertion_content_comment('oboGo_PostEmbryonicpelvicfinmorphogenesis',s("The","process",",","occurring","after","embryonic","development",",","by","which","the","anatomical","structures","of","the","pelvic","fin","are","generated","and","organized",".","The","pelvic","fins","are","bilaterally","paired","fins","mounted","in","a","ventral-lateral","position","on","most","fish",".","These","fins","are","used","primarily","for","lateral","mobility","and","propulsion","."),4382200). assertion_content_comment('oboGo_PostEmbryonicretinamorphogenesisincameraTypeeye',s("The","process","in","which","the","anatomical","structure","of","the","retina","is","generated","and","organized","in","a","camera-type","eye","during","the","post-embryonic","life","stage"),4109307). assertion_content_comment('oboGo_PostEmbryonicrootdevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","the","post-embryonic","root","over","time",",","from","its","formation","to","the","mature","structure","."),4030553). assertion_content_comment('oboGo_PostEmbryonicrootmorphogenesis',s("The","process","in","which","the","anatomical","structures","of","the","post-embryonic","root","are","generated","and","organized",".","The","post-embryonic","root","is","the","root","formed","after","the","embryonic","phase","has","been","completed","."),4030555). assertion_content_comment('oboGo_PostGolgivesicleMediatedtransport',s("The","directed","movement","of","substances","from","the","Golgi","to","other","parts","of","the","cell",",","including","organelles","and","the","plasma","membrane",",","mediated","by","small","transport","vesicles","."),4025284). assertion_content_comment('oboGo_PostLysosomalvacuole',s("A","membrane-bounded","intracellular","vesicle","formed","late","in","the","endocytic","pathway","when","the","pH","in","the","vacuole","becomes","neutral","prior","to","exocytosis","."),4329414). assertion_content_comment('oboGo_PostMatingbehavior',s("The","specific","actions","or","reactions","of","an","organism","following","mating","."),4077823). assertion_content_comment('oboGo_PostMatingoviposition',s("The","deposition","of","eggs",",","either","fertilized","or","not",",","upon","a","surface","or","into","a","medium",",","following","mating","."),4104620). assertion_content_comment('oboGo_PostMrnareleasespliceosomalcomplex',s("A","spliceosomal","complex","that","is","formed","following","the","release","of","the","spliced","product","from","the","post-spliceosomal","complex","and","contains","the","excised","intron","and","three","snRNPs",",","including","U5","."),4167751). assertion_content_comment('oboGo_PostSpliceosomalcomplex',s("A","spliceosomal","complex","that","is","formed","following","the","second","splicing","event","and","contains","the","spliced","product",",","the","excised","intron",",","and","three","snRNPs",",","including","U5","."),4167881). assertion_content_comment('oboGo_PostTranslationalproteinacetylation',s("The","addition","of","an","acetyl","group","to","one","or","more","amino","acids","in","a","protein",",","occurring","after","the","protein","has","been","completely","translated","and","released","from","the","ribosome","."),4357372). assertion_content_comment('oboGo_PostTranslationalproteinmodification',s("The","process","of","covalently","altering","one","or","more","amino","acids","in","a","protein","after","the","protein","has","been","completely","translated","and","released","from","the","ribosome","."),4129695). assertion_content_comment('oboGo_PotassiumIonTransportingatpasecomplex',s("Protein","complex","that","carries","out","the","reaction",":","ATP","+","H2O","+","K","+","(","out",")","=","ADP","+","phosphate","+","K","+","(","in",")","It","is","a","high","affinity","potassium","uptake","system",".","The","E",".","coli","complex","consists","of","4","proteins",":","KdpA","is","the","potassium","ion","translocase",",","KdpB","is","the","ATPase",",","and","KdpC","and","KdpF","seem","to","be","involved","in","assembly","and","stabilization","of","the","complex","."),4319212). assertion_content_comment('oboGo_PotassiumTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","K","+","(","out",")","=","ADP","+","phosphate","+","K","+","(","in",")"),4219110). assertion_content_comment('oboGo_PPBondHydrolysisDrivenproteintransmembranetransporteractivity',s("Primary","active","carrier-mediated","transport","of","a","protein","across","a","membrane",",","driven","by","the","hydrolysis","of","the","diphosphate","bond","of","inorganic","pyrophosphate",",","ATP",",","or","another","nucleoside","triphosphate",".","The","transport","protein","may","or","may","not","be","transiently","phosphorylated",",","but","the","substrate","is","not","phosphorylated","."),4252479). assertion_content_comment('oboGo_PPBondHydrolysisDriventransmembranetransporteractivity',s("Primary","active","transport","of","a","solute","across","a","membrane",",","driven","by","the","hydrolysis","of","the","diphosphate","bond","of","inorganic","pyrophosphate",",","ATP",",","or","another","nucleoside","triphosphate",".","The","transport","protein","may","or","may","not","be","transiently","phosphorylated",",","but","the","substrate","is","not","phosphorylated",".","Primary","active","transport","is","catalysis","of","the","transport","of","a","solute","across","a","membrane",",","up","the","solute","'","s","concentration","gradient",",","by","binding","the","solute","and","undergoing","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","a","primary","energy","source","."),4168925). assertion_content_comment('oboGo_PRDubcomplex',s("A","multimeric","protein","complex","that","removes","monoubiquitin","from","histone","H2A",".","In","Drosophila","and","mammals",",","the","core","of","the","complex","is","composed","of","Calypso/BAP1","and","Asx/ASXL1",",","respectively","."),4378988). assertion_content_comment('oboGo_PreAutophagosomalstructuremembrane',s("A","cellular","membrane","associated","with","the","pre-autophagosomal","structure","."),4077103). assertion_content_comment('oboGo_PreAutophagosomalstructure',s("A","punctate","structure","localized","in","the","vicinity","of","the","vacuole","that","is","required","for","the","formation","of","autophagosomes","."),4077087). assertion_content_comment('oboGo_PreBcellallelicexclusion',s("Expression","of","a","single","heavy","chain","allele","during","pre-B","cell","differentiation","."),4379781). assertion_content_comment('oboGo_PreBcelldifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","pre-B","cell",".","Pre-B","cells","follow","the","pro-B","cell","stage","of","immature","B","cell","differentiation","and","undergo","rearrangement","of","heavy","chain","V",",","D",",","and","J","gene","segments","."),4379659). assertion_content_comment('oboGo_PreBcellreceptorcomplex',s("An","immunoglobulin-like","complex","that","is","present","in","at","least","the","plasma","membrane","of","pre-B","cells",",","and","that","is","composed","of","two","identical","immunoglobulin","heavy","chains","and","two","surrogate","light","chains",",","each","composed","of","the","lambda-5","and","VpreB","proteins",",","and","a","signaling","subunit",",","a","heterodimer","of","the","Ig-alpha","and","Ig-beta","proteins","."),4383039). assertion_content_comment('oboGo_PreBcellreceptorexpression',s("The","process","leading","up","to","expression","of","the","pre-B","cell","receptor","on","the","surface","of","pre-B","cells",",","including","expression","of","the","surrogate","light","chain",",","association","of","the","surrogate","light","chain","with","heavy","chain",",","and","expression","of","the","complete","pre-B","cell","receptor","on","the","cell","surface","."),4379670). assertion_content_comment('oboGo_Precorrin_2C20_MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","precorrin-2","=","S-adenosyl-L-homocysteine","+","H","(","+",")","+","precorrin-3A","."),4309027). assertion_content_comment('oboGo_Precorrin_2DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","(","+",")","+","precorrin-2","=","2","H","(","+",")","+","NADH","+","sirohydrochlorin","."),4256432). assertion_content_comment('oboGo_Precorrin_3BC17_MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","precorrin-3B","=","S-adenosyl-L-homocysteine","+","precorrin","4","."),4309000). assertion_content_comment('oboGo_Precorrin_3BSynthaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADH","+","O","(","2",")","+","precorrin-3A","=","H","(","2",")","O","+","NAD","(","+",")","+","precorrin-3B","."),4327593). assertion_content_comment('oboGo_Precorrin_4C11_MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","precorrin-4","=","S-adenosyl-L-homocysteine","+","precorrin","5","."),4348107). assertion_content_comment('oboGo_Precorrin_6AReductaseActivity',s("Catalysis","of","the","reaction",":","precorrin-6B","+","NADP","+","=","precorrin-6A","+","NADPH","+","H","+"),4302394). assertion_content_comment('oboGo_Precorrin_6ASynthaseDeacetylatingActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","H","(","2",")","O","+","precorrin-5","=","S-adenosyl-L-homocysteine","+","acetate","+","2","H","(","+",")","+","precorrin-6X","."),4327606). assertion_content_comment('oboGo_Precorrin_6YC515_MethyltransferaseDecarboxylatingActivity',s("Catalysis","of","the","reaction",":","2","S-adenosyl-L-methionine","+","precorrin-6Y","=","2","S-adenosyl-L-homocysteine","+","precorrin-8X","+","CO2","."),4348119). assertion_content_comment('oboGo_Precorrin_8XMethylmutaseActivity',s("Catalysis","of","the","reaction",":","precorrin-8X","=","hydrogenobyrinate","."),4302349). assertion_content_comment('oboGo_Pregnan_21_OlDehydrogenaseNADActivity',s("Catalysis","of","the","reaction",":","NAD","(","+",")","+","pregnan-21-ol","=","H","(","+",")","+","NADH","+","pregnan-21-al","."),4364416). assertion_content_comment('oboGo_Pregnan_21_OlDehydrogenaseNADPActivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","pregnan-21-ol","=","H","(","+",")","+","NADPH","+","pregnan-21-al","."),4364456). assertion_content_comment('oboGo_PreMicrornaContainingribonucleoproteincomplexexportfromnucleus',s("The","directed","movement","of","a","ribonucleoprotein","complex","that","contains","pre-microRNA","from","the","nucleus","to","the","cytoplasm","."),4164019). assertion_content_comment('oboGo_PreMicrornaexportfromnucleus',s("Transport","of","pre-microRNAs","(","pre-miRNAs",")","from","the","nucleus","to","the","cytoplasm",".","Pre-miRNAs","are","a","~","60-70","nucleotide","stem","loop","intermediate","in","miRNA","production",",","produced","by","the","nuclear","cleavage","of","a","primary","miRNA","(","pri-mRNA",")","transcript",".","Pre-miRNAs","are","transported","from","the","nucleus","to","the","cytoplasm","where","further","cleavage","occurs","to","produce","a","mature","miRNA","product","."),4071020). assertion_content_comment('oboGo_PreMicrornaprocessing',s("Any","process","involved","in","the","conversion","of","a","pre-microRNA","transcript","into","a","mature","microRNA","molecule","."),4061063). assertion_content_comment('oboGo_PreMirnabinding',s("Interacting","selectively","and","non-covalently","with","a","precursor","microRNA","(","pre-miRNA",")","transcript",",","a","stem-loop-containing","precursor","of","microRNA","."),4178391). assertion_content_comment('oboGo_PreMrna3Splicesitebinding',s("Interacting","selectively","and","non-covalently","with","the","pre-mRNA","3","'","splice","site","sequence","."),4307968). assertion_content_comment('oboGo_PreMrna5Splicesitebinding',s("Interacting","selectively","and","non-covalently","with","the","pre-mRNA","5","'","splice","site","sequence","."),4307884). assertion_content_comment('oboGo_PreMrnabranchpointbinding',s("Interacting","selectively","and","non-covalently","with","a","pre-mRNA","branch","point","sequence",",","located","upstream","of","the","3","'","splice","site","."),4300026). assertion_content_comment('oboGo_PreMrnacleavagefactoractivity',s("OBSOLETE",".","Any","activity","required","for","the","process","of","mRNA","cleavage","."),4309874). assertion_content_comment('oboGo_PreMrnasplicingfactoractivity',s("OBSOLETE",".","An","activity","involved","in","the","removal","of","an","intron","from","a","pre-mRNA","."),4255940). assertion_content_comment('oboGo_PrenylDependentcaaxproteaseactivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4254322). assertion_content_comment('oboGo_PrenylDiphosphataseactivity',s("Catalysis","of","the","reaction",":","prenyl","diphosphate","+","H2O","=","prenol","+","diphosphate","."),4264348). assertion_content_comment('oboGo_PreReplicativecomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","the","pre-replicative","complex",",","a","protein-DNA","complex","that","forms","at","eukaryotic","DNA","replication","origins","during","late","M","phase",";","its","presence","is","required","for","replication","initiation","."),4010924). assertion_content_comment('oboGo_PreReplicativecomplex',s("A","protein-DNA","complex","assembled","at","eukaryotic","DNA","replication","origins","during","late","mitosis","and","G1",",","allowing","the","origin","to","become","competent",",","or","'","licensed","'",",","for","replication",".","The","complex","normally","includes","the","origin","recognition","complex","(","ORC",")",",","Cdc6",",","Cdt1","and","the","MiniChromosome","Maintenance","(","Mcm2-7",")","proteins","."),4220211). assertion_content_comment('oboGo_PresequenceTranslocaseAssociatedimportmotor',s("Protein","complex","located","on","the","matrix","side","of","the","mitochondrial","inner","membrane","and","associated","with","the","presequence","translocase","complex",";","hydrolyzes","ATP","to","provide","the","force","to","drive","import","of","proteins","into","the","mitochondrial","matrix","."),3981802). assertion_content_comment('oboGo_PreSnornpcomplex',s("A","ribonucleoprotein","complex","that","contains","a","precursor","small","nucleolar","RNA","(","pre-snoRNA",")","and","associated","proteins",",","and","forms","during","small","nucleolar","ribonucleoprotein","complex","(","snoRNP",")","assembly",".","Pre-snoRNP","complexes","may","contain","proteins","not","found","in","the","corresponding","mature","snoRNP","complexes","."),4176353). assertion_content_comment('oboGo_PreTcellreceptorcomplex',s("A","receptor","complex","found","on","immature","T","cells","consisting","of","a","T","cell","receptor","beta","chain","and","the","pre-TCR-alpha","chain",",","along","with","additional","signaling","components","including","CD3","family","members","and","additional","signaling","proteins","."),4095756). assertion_content_comment('oboGo_PreTubularaggregateformation',s("The","cell","adhesion","process","in","which","mesenchyme","cells","adhere","to","one","another","in","the","initial","stages","of","the","formation","of","the","pre-tubular","aggregate",",","the","earliest","recognizable","structure","of","the","kidney","."),4123542). assertion_content_comment('oboGo_PrimarySexDeterminationGermLine',s("The","transmission","of","information","about","sexual","status",",","from","the","initial","general","determination",",","to","signals","specific","to","the","germ-line","."),4015948). assertion_content_comment('oboGo_PriMirnabinding',s("Interacting","selectively","and","non-covalently","with","a","primary","microRNA","(","pri-miRNA",")","transcript",",","an","RNA","molecule","that","is","processed","into","a","short","hairpin-shaped","structure","called","a","pre-miRNA","and","finally","into","a","functional","miRNA",".","Both","double-stranded","and","single-stranded","regions","of","a","pri-miRNA","are","required","for","binding","."),4178570). assertion_content_comment('oboGo_PristanateCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","pristanate","+","CoA","=","AMP","+","diphosphate","+","pristanoyl-CoA","."),4173844). assertion_content_comment('oboGo_PristanoylCoaoxidaseactivity',s("Catalysis","of","the","reaction",":","pristanoyl-CoA","+","O2","=","trans-2",",","3-dehydropristanoyl-CoA","+","hydrogen","peroxide","."),4304788). assertion_content_comment('oboGo_ProBcelldifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","pro-B","cell",".","Pro-B","cells","are","the","earliest","stage","of","the","B","cell","lineage","and","undergo","heavy","chain","D","and","J","gene","rearrangements",",","although","they","are","not","fully","committed","."),4379633). assertion_content_comment('oboGo_ProboscisMorphogenesisClypeoLabraldiscDerived',s("The","process","in","which","the","anatomical","structures","of","the","proboscis","that","are","derived","from","the","clypeo-labral","disc","are","generated","and","organized","."),4025248). assertion_content_comment('oboGo_ProboscisMorphogenesisEyeAntennaldiscDerived',s("The","process","in","which","the","anatomical","structures","of","the","proboscis","that","are","derived","from","the","eye-antennal","disc","are","generated","and","organized","."),4025259). assertion_content_comment('oboGo_ProboscisMorphogenesisLabialDiscDerived',s("The","process","in","which","the","anatomical","structures","of","the","proboscis","that","are","derived","from","the","labial","disc","are","generated","and","organized","."),4025227). assertion_content_comment('oboGo_ProcessingOf27SPreRrna',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4310249). assertion_content_comment('oboGo_ProcollagenCEndopeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","the","C-terminal","propeptide","at","Ala-Asp","in","type","I","and","II","procollagens","and","at","Arg-Asp","in","type","III","."),4268729). assertion_content_comment('oboGo_ProcollagenLysine5Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","procollagen","L-lysine","+","2-oxoglutarate","+","O2","=","procollagen","5-hydroxy-L-lysine","+","succinate","+","CO2","."),4254170). assertion_content_comment('oboGo_ProcollagenNEndopeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","the","N-propeptide","of","collagen","chain","alpha-1","(","I",")","at","Pro-Gln","and","of","alpha-1","(","II",")","and","alpha-2","(","I",")","chains","at","Ala-Gln","."),4269425). assertion_content_comment('oboGo_ProcollagenProline3Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","procollagen","L-proline","+","2-oxoglutarate","+","O2","=","procollagen","trans-3-hydroxy-L-proline","+","succinate","+","CO2","."),4234326). assertion_content_comment('oboGo_ProcollagenProline4Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","procollagen","L-proline","+","2-oxoglutarate","+","O2","=","procollagen","trans-4-hydroxy-L-proline","+","succinate","+","CO2","."),4203264). assertion_content_comment('oboGo_ProcollagenProline4Dioxygenasecomplexalphaiiitype',s("A","procollagen-proline","4-dioxygenase","complex","that","contains","alpha","subunits","of","the","type","III","isoform","."),4173473). assertion_content_comment('oboGo_ProcollagenProline4Dioxygenasecomplexalphaiitype',s("A","procollagen-proline","4-dioxygenase","complex","that","contains","alpha","subunits","of","the","type","II","isoform",";","its","activity","is","inhibited","by","poly","(","L-proline",")","only","at","high","concentrations","."),4173484). assertion_content_comment('oboGo_ProcollagenProline4Dioxygenasecomplexalphaitype',s("A","procollagen-proline","4-dioxygenase","complex","that","contains","alpha","subunits","of","the","type","I","isoform",";","its","activity","is","readily","inhibited","by","poly","(","L-proline",")"),4173495). assertion_content_comment('oboGo_ProcollagenProline4Dioxygenasecomplex',s("A","protein","complex","that","catalyzes","the","formation","of","procollagen","trans-4-hydroxy-L-proline","and","succinate","from","procollagen","L-proline","and","2-oxoglutarate",",","requiring","Fe2","+","and","ascorbate",".","Contains","two","alpha","subunits","that","contribute","to","most","parts","of","the","catalytic","sites",",","and","two","beta","subunits","that","are","identical","to","protein-disulfide","isomerase","."),4173469). assertion_content_comment('oboGo_ProcollagenProlinedioxygenaseactivity',s("Catalysis","of","the","reaction",":","procollagen","L-proline","+","2-oxoglutarate","+","O2","=","procollagen","trans-hydroxy-L-proline","+","succinate","+","CO2","."),4203250). assertion_content_comment('oboGo_ProductionOfTaSirnasinvolvedinrnainterference',s("Cleavage","of","double-stranded","RNA","to","form","trans-acting","small","interfering","RNA","molecules","(","siRNAs",")","of","21-23","nucleotides",".","ta-siRNAs","arise","from","PolII","genes","and","function","like","miRNAs","to","guide","cleavage","of","target","mRNAs","."),4335396). assertion_content_comment('oboGo_Progesterone11AlphaMonooxygenaseactivity',s("Catalysis","of","the","reaction",":","AH","(","2",")","+","O","(","2",")","+","progesterone","=","11alpha-hydroxyprogesterone","+","A","+","H","(","2",")","O","."),4263266). assertion_content_comment('oboGo_Progesterone5AlphaReductaseactivity',s("Catalysis","of","the","reaction",":","5-alpha-pregnan-3",",","20-dione","+","NADP","+","=","progesterone","+","NADPH","."),4263309). assertion_content_comment('oboGo_ProlactinReleasingpeptidereceptorbinding',s("Interacting","selectively","and","non-covalently","with","a","prolactin-releasing","peptide","receptor","."),4324083). assertion_content_comment('oboGo_Proline3Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","L-proline","+","2-oxoglutarate","+","O2","=","cis-3-hydroxy-L-proline","+","succinate","+","CO2","."),4342712). assertion_content_comment('oboGo_ProlineCatabolicProcessTo2Oxoglutarate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","proline","into","other","compounds",",","including","2-oxoglutarate","."),4240982). assertion_content_comment('oboGo_ProlineRichregionbinding',s("Interacting","selectively","and","non-covalently","with","a","proline-rich","region",",","i.e",".","a","region","that","contains","a","high","proportion","of","proline","residues",",","in","a","protein","."),4180031). assertion_content_comment('oboGo_ProlineTrnaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","L-proline","+","tRNA","(","Pro",")","=","AMP","+","diphosphate","+","L-prolyl-tRNA","(","Pro",")"),4199779). assertion_content_comment('oboGo_ProlylTrnaaminoacylation',s("The","process","of","coupling","proline","to","prolyl-tRNA",",","catalyzed","by","prolyl-tRNA","synthetase",".","In","tRNA","aminoacylation",",","the","amino","acid","is","first","activated","by","linkage","to","AMP","and","then","transferred","to","either","the","2","'","-","or","the","3","'","-hydroxyl","group","of","the","3","'","-adenosine","residue","of","the","tRNA","."),4179466). assertion_content_comment('oboGo_PromoterClearanceDuringDNADependenttranscription',s("Any","process","involved","in","the","transition","from","the","initiation","to","the","elongation","phases","of","transcription","by","a","DNA-dependent","RNA","polymerase",",","generally","including","a","conformational","change","from","the","initiation","conformation","to","the","elongation","conformation",".","Promoter","clearance","often","involves","breaking","contact","with","transcription","factors","involved","only","in","the","initiation","phase","and","making","contacts","with","elongation","specific","factors","."),3980399). assertion_content_comment('oboGo_PromoterClearanceFromBacterialTypernapolymerasepromoter',s("Any","process","involved","in","the","transition","from","the","initiation","to","the","elongation","phase","of","transcription","by","a","bacterial-type","RNA","polymerase",",","generally","including","a","conformational","change","from","the","initiation","conformation","to","the","elongation","conformation",".","Promoter","clearance","generally","involves","dissociation","of","the","sigma","initiation","factor","."),3980581). assertion_content_comment('oboGo_Propane_13_DiamineOxidaseActivity',s("Catalysis","of","the","reaction",":","propane-1",",","3-diamine","+","H2O","+","O2","=","3-aminopropanal","+","NH3","+","hydrogen","peroxide","+","H","+"),4191007). assertion_content_comment('oboGo_PropanediolPhosphatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NAD","(","+",")","+","propane-1",",","2-diol","1-phosphate","=","H","(","+",")","+","hydroxyacetone","phosphate","+","NADH","."),4263211). assertion_content_comment('oboGo_PropanoylCoacAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","3alpha",",","7alpha",",","12alpha-trihydroxy-5beta-cholanoyl-CoA","+","propanoyl-CoA","=","CoA","+","3alpha",",","7alpha",",","12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA","."),4343109). assertion_content_comment('oboGo_PropionateCatabolicProcess2Methylcitratecycle',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","propionate","that","occurs","in","the","2-methylcitrate","cycle","."),4243846). assertion_content_comment('oboGo_PropionateCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","propanoate","+","CoA","=","AMP","+","diphosphate","+","propanoyl-CoA","."),4263242). assertion_content_comment('oboGo_PropionateCoATransferaseactivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","propanoate","=","acetate","+","propanoyl-CoA","."),4275006). assertion_content_comment('oboGo_PropionylCoac2Trimethyltridecanoyltransferaseactivity',s("Catalysis","of","the","reaction",":","4",",","8",",","12-trimethyltridecanoyl-CoA","+","propanoyl-CoA","=","3-oxopristanoyl-CoA","+","CoA","."),4277838). assertion_content_comment('oboGo_PropionylCoacarboxylaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","propanoyl-CoA","+","HCO3-","=","ADP","+","phosphate","+","(","S",")","-methylmalonyl-CoA","."),4203209). assertion_content_comment('oboGo_PropionylCoadehydrogenaseactivity',s("Catalysis","of","the","irreversible","NADH-dependent","formation","of","propionyl-CoA","from","acryloyl-CoA","."),4327132). assertion_content_comment('oboGo_PropionylCoa_SuccinatecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","succinate","+","propionyl-CoA","=","succinyl-CoA","+","propionate","."),4327142). assertion_content_comment('oboGo_ProstaglandinA1deltaIsomeraseactivity',s("Catalysis","of","the","reaction",":","prostaglandin","A1","=","prostaglandin","C1","."),4263323). assertion_content_comment('oboGo_ProstaglandinDsynthaseactivity',s("Catalysis","of","the","reaction",":","prostaglandin","H","(","2",")","=","prostaglandin","D","(","2",")"),4202493). assertion_content_comment('oboGo_ProstaglandinE29Reductaseactivity',s("Catalysis","of","the","reaction",":","(","5Z",",","13E",")","-","(","15S",")","-9-alpha",",","11-alpha",",","15-trihydroxyprosta-5",",","13-dienoate","+","NADP","+","=","(","5Z",",","13E",")","-","(","15S",")","-11-alpha",",","15-dihydroxy-9-oxoprosta-5",",","13-dienoate","+","NADPH","."),4263355). assertion_content_comment('oboGo_ProstaglandinEndoperoxidesynthaseactivity',s("Catalysis","of","the","reaction",":","arachidonate","+","donor-H2","+","2","O2","=","prostaglandin","H2","+","acceptor","+","H2O","."),4202476). assertion_content_comment('oboGo_ProstaglandinEsynthaseactivity',s("Catalysis","of","the","reaction",":","prostaglandin","H","(","2",")","=","prostaglandin","E","(","2",")"),4263335). assertion_content_comment('oboGo_ProstaglandinF2Alphareceptorbinding',s("Interacting","selectively","and","non-covalently","with","a","prostaglandin","F2-alpha","receptor","."),4323804). assertion_content_comment('oboGo_ProstaglandinFsynthaseactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","(","5Z",",","13E",")","-","(","15S",")","-9-alpha",",","11-alpha",",","15-trihydroxyprosta-5",",","13-dienoate","=","NADPH","+","H","+","+","(","5Z",",","13E",")","-","(","15S",")","-9-alpha",",","15-dihydroxy-11-oxoprosta-5",",","13-dienoate","."),4364132). assertion_content_comment('oboGo_ProstaglandinIsynthaseactivity',s("Catalysis","of","the","reaction",":","prostaglandin","H","(","2",")","=","prostaglandin","I","(","2",")"),4246312). assertion_content_comment('oboGo_ProTcelldifferentiation',s("The","process","in","which","a","precursor","cell","type","acquires","the","specialized","features","of","a","pro-T","cell",".","Pro-T","cells","are","the","earliest","stage","of","the","T","cell","lineage","but","are","not","fully","committed","."),3996200). assertion_content_comment('oboGo_ProTcelllineagecommitment',s("The","process","in","which","a","lymphoid","progenitor","cell","becomes","committed","to","becoming","a","pro-T","cell","."),3998444). assertion_content_comment('oboGo_ProteasomalUbiquitinDependentproteincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds",",","initiated","by","the","covalent","attachment","of","ubiquitin",",","and","mediated","by","the","proteasome","."),4012079). assertion_content_comment('oboGo_ProteasomalUbiquitinIndependentproteincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds","that","is","mediated","by","the","proteasome","but","do","not","involve","ubiquitin","."),4332774). assertion_content_comment('oboGo_ProteasomeActivatingnucleotidasecomplex',s("A","multisubunit","complex","that","recognizes","and","unfolds","core","proteasome","substrate","proteins",",","and","translocates","them","to","the","core","complex","in","an","ATP","dependent","manner","."),4053706). assertion_content_comment('oboGo_ProteasomeCoreComplexAlphaSubunitcomplex',s("The","proteasome","core","subcomplex","that","constitutes","the","two","outer","rings","of","the","proteasome","core","complex",".","An","example","of","this","component","is","found","in","Mus","musculus","."),4042422). assertion_content_comment('oboGo_ProteasomeCoreComplexBetaSubunitcomplex',s("The","proteasome","core","subcomplex","that","constitutes","the","two","inner","rings","of","the","proteasome","core","complex",".","An","example","of","this","component","is","found","in","Mus","musculus","."),4042411). assertion_content_comment('oboGo_ProtectionFromNonHomologousendjoiningattelomere',s("A","process","that","prevents","non-homologous","end","joining","at","telomere",",","thereby","ensuring","that","telomeres","do","not","fuse","."),4056683). assertion_content_comment('oboGo_ProteinADPRibosylation',s("The","transfer",",","from","NAD",",","of","ADP-ribose","to","protein","amino","acids","."),4036634). assertion_content_comment('oboGo_ProteinAminoAcidTerminalNGlycosylation',s("The","glycosylation","of","a","nitrogen","atom","of","a","free","alpha","amino","terminal","of","a","peptide","."),4231111). assertion_content_comment('oboGo_ProteinArgininedeiminaseactivity',s("Catalysis","of","the","reaction",":","protein","L-arginine","+","H2O","=","protein","L-citrulline","+","NH3","."),4202509). assertion_content_comment('oboGo_ProteinArgininen5Methyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosyl-L-methionine","to","the","delta-nitrogen","atom","of","peptidyl-arginine","residues","."),4245646). assertion_content_comment('oboGo_ProteinArgininenMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","(","protein",")","-arginine","=","S-adenosyl-L-homocysteine","+","(","protein",")","-N-methyl-arginine","."),4177082). assertion_content_comment('oboGo_ProteinArginineomegaNasymmetricmethyltransferaseactivity',s("Catalysis","of","the","addition","of","a","second","methyl","group","to","methylated","peptidyl-arginine",".","Methylation","is","on","the","same","terminal","nitrogen","(","omega","nitrogen",")","residue","that","was","previously","methylated",",","resulting","in","asymmetrical","peptidyl-N","(","omega",")",",","N","(","omega",")","-dimethylated","arginine","residues","."),4382584). assertion_content_comment('oboGo_ProteinArginineomegaNmonomethyltransferaseactivity',s("Catalysis","of","the","addition","of","a","methyl","group","to","either","of","the","unmethylated","terminal","nitrogen","atoms","(","also","called","omega","nitrogen",")","in","peptidyl-arginine","to","form","an","omega-N-G-monomethylated","arginine","residue","."),4382595). assertion_content_comment('oboGo_ProteinArginineomegaNsymmetricmethyltransferaseactivity',s("Catalysis","of","the","addition","of","a","second","methyl","group","to","methylated","peptidyl-arginine",".","Methylation","is","on","the","terminal","nitrogen","(","omega","nitrogen",")","residue","that","is","not","already","methylated",",","resulting","in","symmetrical","peptidyl-N","(","omega",")",",","N","'","(","omega",")","-dimethyled","arginine","residues","."),4382562). assertion_content_comment('oboGo_ProteinAutoAdpRibosylation',s("The","ADP-ribosylation","by","a","protein","of","one","or","more","of","its","own","amino","acid","residues",",","or","residues","on","an","identical","protein","."),4173981). assertion_content_comment('oboGo_ProteinBasedcuticleattachmenttoepithelium',s("Attaching","of","a","protein-based","cuticle","to","the","epithelium","underlying","it","."),4015244). assertion_content_comment('oboGo_ProteinBasedcuticledevelopment',s("Synthesis","and","deposition","of","a","protein-based","noncellular",",","hardened",",","or","membranous","secretion","from","an","epithelial","sheet",".","An","example","of","this","is","found","in","Caenorhabditis","elegans","."),4020632). assertion_content_comment('oboGo_ProteinBilinlinkage',s("The","covalent","linkage","of","bilin","and","a","protein","."),4265903). assertion_content_comment('oboGo_ProteinCarbohydratecomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","carbohydrates","to","form","a","protein-carbohydrate","complex","."),3996130). assertion_content_comment('oboGo_ProteinCarbohydratecomplexdisassembly',s("The","disaggregation","of","a","protein-carbohydrate","complex","into","its","constituent","components","."),4337076). assertion_content_comment('oboGo_ProteinCarbohydratecomplex',s("A","macromolecular","complex","containing","both","protein","and","carbohydrate","molecules","."),4172346). assertion_content_comment('oboGo_ProteinCarbohydratecomplexsubunitorganization',s("Any","process","in","which","macromolecules","aggregate",",","disaggregate",",","or","are","modified",",","resulting","in","the","formation",",","disassembly",",","or","alteration","of","a","protein-carbohydrate","complex","."),3996128). assertion_content_comment('oboGo_ProteinCarboxylOMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","a","carboxyl","group","on","a","protein","."),4183608). assertion_content_comment('oboGo_ProteinCatenaneFormationViaN6LIsoaspartylLLysineautocatalytic',s("The","autocatalytic","formation","of","isopeptide","bonds","by","ligation","of","peptidyl-lysine","and","peptidyl-asparagine","residues",";","known","to","occur","in","the","capsid","of","some","bacteriophage",",","such","as","HK97",",","where","it","is","thought","to","provide","a","mechanism","for","stabilizing","the","capsid","."),4233090). assertion_content_comment('oboGo_ProteinChondroitinsulfatelinkageviachondroitinsulfatedGlucuronylDGalactosylDGalactosylDXylosylLSerine',s("Chondroitin","sulfate","components","are","covalently","linked","to","a","core","glycoprotein","via","O-glycosidic","linkages","between","xylose","and","serine","residues","."),4281314). assertion_content_comment('oboGo_ProteinChromophorelinkage',s("The","covalent","or","noncovalent","attachment","of","a","chromophore","to","a","protein","."),4232774). assertion_content_comment('oboGo_ProteinChromophorelinkageviapeptidylCysteine',s("The","covalent","linking","of","a","chromophore","to","a","protein","via","peptidyl-cysteines","."),4232776). assertion_content_comment('oboGo_Protein_ChromophoreLinkageViaPeptidyl_N6_3_Dehydroretinal_L_Lysine',s("The","modification","of","peptidyl-lysine","to","form","N6-3",",","4-didehydroretinylidene-L-lysine","."),4233007). assertion_content_comment('oboGo_ProteinChromophorelinkageviapeptidylN6RetinalLLysine',s("The","modification","of","peptidyl-lysine","to","form","N6-retinal-L-lysine","."),4280569). assertion_content_comment('oboGo_Protein_ChromophoreLinkageViaPeptidyl_S_4_Hydroxycinnamyl_L_Cysteine',s("The","synthesis","of","the","chromophore","S-4-hydroxycinnamyl-L-cysteine","."),4279669). assertion_content_comment('oboGo_ProteinCInhibitorAcrosincomplex',s("A","heterodimeric","protein","complex","of","protein","C","inhibitor","and","acrosin",";","complex","formation","inhibits","the","protease","activity","of","acrosin","."),4066418). assertion_content_comment('oboGo_ProteinCLinkedglycosylation',s("A","protein","glycosylation","process","in","which","a","sugar","unit","is","added","to","a","protein","via","a","C","atom","."),4279361). assertion_content_comment('oboGo_ProteinCLinkedglycosylationvia2AlphaMannosylLTryptophan',s("The","glycosylation","of","a","peptidyl-tryptophan","residue","by","the","transfer","of","alpha-mannopyranose","from","dolichyl-activated","mannose","to","the","indole","ring","."),4281246). assertion_content_comment('oboGo_ProteinCLinkedglycosylationviatryptophan',s("The","glycosylation","of","a","carbon","atom","of","a","peptidyl-tryptophan","residue","."),4279365). assertion_content_comment('oboGo_ProteinCoenzymealinkage',s("The","formation","of","a","linkage","between","a","protein","amino","acid","and","coenzyme","A","."),4280410). assertion_content_comment('oboGo_ProteinCofactorlinkage',s("The","covalent","attachment","of","a","cofactor","to","a","protein","."),4257401). assertion_content_comment('oboGo_ProteinCTerminalamidation',s("The","formation","of","a","C-terminal","amide","by","hydrolysis","and","oxidation","of","an","interior","peptide","in","a","secreted","protein","."),4282910). assertion_content_comment('oboGo_ProteinCTerminalcarboxyloMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","the","oxygen","atom","of","a","carboxyl","group","at","the","C-terminal","of","a","protein","."),4189904). assertion_content_comment('oboGo_ProteinCTerminalleucinecarboxyloMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","protein","L-leucine","=","S-adenosyl-L-homocysteine","+","protein","L-leucine","methyl","ester",".","This","modification","occurs","only","at","the","oxygen","atoms","of","the","free","alpha","carboxyl","group","of","a","leucine","residue","at","the","C-terminus","of","the","protein","."),4281807). assertion_content_comment('oboGo_ProteinCTerminalmethylesteraseactivity',s("Catalysis","of","the","reaction",":","C-terminal","protein","amino","acid","methyl","ester","+","H2O","=","protein","amino","acid","+","methanol","."),4280891). assertion_content_comment('oboGo_ProteinCTerminalsIsoprenylcysteinecarboxyloMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","protein","C-terminal","S-farnesyl-L-cysteine","=","S-adenosyl-L-homocysteine","+","protein","C-terminal","S-farnesyl-L-cysteine","methyl","ester","."),4202330). assertion_content_comment('oboGo_ProteinCTerminusbinding',s("Interacting","selectively","and","non-covalently","with","a","protein","C-terminus",",","the","end","of","any","peptide","chain","at","which","the","1-carboxy","function","of","a","constituent","amino","acid","is","not","attached","in","peptide","linkage","to","another","amino-acid","residue","."),4247001). assertion_content_comment('oboGo_ProteinCysteinesAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","acyl","group","to","a","sulfur","atom","on","the","cysteine","of","a","protein","molecule","."),4245614). assertion_content_comment('oboGo_ProteinCysteinesMyristoyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","myristoyl","group","to","a","sulfur","atom","on","a","cysteine","residue","of","a","protein","molecule","."),4245616). assertion_content_comment('oboGo_ProteinCysteinesPalmitoleyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","palmitoleyl","group","to","a","sulfur","atom","on","the","cysteine","of","a","protein","molecule","."),4245626). assertion_content_comment('oboGo_ProteinCysteineThioloxidation',s("OBSOLETE",".","Oxidation","of","two","cysteine","sulfhydryl","groups","(","thiols",")","in","one","protein","by","a","disulfide","bond","in","a","second","protein","to","form","a","disulfide","bond","in","the","first","protein","and","two","reduced","sulfhydryls","in","the","second",".","The","oxidized","cysteines","linked","by","a","disulfide","bond","is","known","as","cystine","."),4231168). assertion_content_comment('oboGo_ProteinDeAdpRibosylation',s("The","process","of","removing","one","or","more","ADP-ribose","residues","from","a","protein","."),4280857). assertion_content_comment('oboGo_ProteinDermatansulfatelinkageviadermatan4SulfatedGlucuronylDGalactosylDGalactosylDXylosylLSerine',s("Dermatan","sulfate","components","are","covalently","linked","to","a","core","glycoprotein","via","O-glycosidic","linkages","between","xylose","and","serine","residues","."),4281325). assertion_content_comment('oboGo_ProteinDeubiquitinationInvolvedInUbiquitinDependentproteincatabolicprocess',s("The","removal","of","one","or","more","ubiquitin","groups","from","a","protein","as","part","of","a","process","of","ubiquitin-dependent","protein","catabolism","."),4125939). assertion_content_comment('oboGo_ProteinDisulfideIsomerasereaction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4223973). assertion_content_comment('oboGo_ProteinDisulfidereductaseactivity',s("Catalysis","of","the","reaction",":","protein-dithiol","+","NAD","(","P",")","+","=","protein-disulfide","+","NAD","(","P",")","H","+","H","+"),4365592). assertion_content_comment('oboGo_ProteinDisulfidereductaseglutathioneactivity',s("Catalysis","of","the","reaction",":","2","glutathione","+","protein-disulfide","=","oxidized","glutathione","+","protein-dithiol","."),4228196). assertion_content_comment('oboGo_ProteinDisulfidereduction',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4228215). assertion_content_comment('oboGo_ProteinDnacomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","DNA","molecules","to","form","a","protein-DNA","complex","."),3977223). assertion_content_comment('oboGo_ProteinDnacomplexdisassembly',s("The","disaggregation","of","a","protein-DNA","complex","into","its","constituent","components","."),4011109). assertion_content_comment('oboGo_ProteinDnacomplexremodeling',s("The","acquisition",",","loss",",","or","modification","of","macromolecules","within","a","complex",",","resulting","in","the","alteration","of","an","existing","complex","."),3980447). assertion_content_comment('oboGo_ProteinDnacomplex',s("A","macromolecular","complex","containing","both","protein","and","DNA","molecules","."),3978439). assertion_content_comment('oboGo_ProteinDnacomplexsubunitorganization',s("Any","process","in","which","macromolecules","aggregate",",","disaggregate",",","or","are","modified",",","resulting","in","the","formation",",","disassembly",",","or","alteration","of","a","protein-DNA","complex","."),3977220). assertion_content_comment('oboGo_ProteinDnacomplextransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","protein-DNA","complexes","from","one","side","of","a","membrane","to","the","other","."),4295603). assertion_content_comment('oboGo_ProteinDnacomplextransport',s("The","directed","movement","of","protein-DNA","complexes","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4294298). assertion_content_comment('oboGo_ProteinDnacovalentcrossLinking',s("The","formation","of","a","covalent","cross-link","between","DNA","and","a","protein","."),4284507). assertion_content_comment('oboGo_ProteinDnacovalentcrossLinkingviapeptidylSerine',s("The","formation","of","a","covalent","cross-link","between","DNA","and","a","peptidyl-serine","residue","by","the","formation","of","O-","(","phospho-5","'","-DNA",")","-L-serine","."),4284845). assertion_content_comment('oboGo_ProteinDnacovalentcrossLinkingviapeptidylThreonine',s("The","formation","of","a","covalent","cross-link","between","DNA","and","a","peptidyl-threonine","residue","by","the","formation","of","O-","(","phospho-5","'","-DNA",")","-L-threonine","."),4284511). assertion_content_comment('oboGo_ProteinDnacovalentcrossLinkingviapeptidylTyrosine',s("The","formation","of","a","covalent","cross-link","between","DNA","and","a","peptidyl-tyrosine","residue","."),4284531). assertion_content_comment('oboGo_ProteinDnacovalentcrossLinkingviathe3EndtopeptidylTyrosine',s("The","formation","of","a","covalent","cross-link","between","DNA","and","a","peptidyl-tyrosine","residue","by","the","formation","of","O4","'","-","(","phospho-3","'","-DNA",")","-L-tyrosine","."),4298472). assertion_content_comment('oboGo_ProteinDnacovalentcrossLinkingviathe5EndtopeptidylTyrosine',s("The","formation","of","a","covalent","cross-link","between","DNA","and","a","peptidyl-tyrosine","residue","by","the","formation","of","O4","'","-","(","phospho-5","'","-DNA",")","-L-tyrosine","."),4284534). assertion_content_comment('oboGo_ProteinDnaisrecomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","DNA","molecules","to","form","a","protein-DNA","complex",",","in","which","the","complex","is","formed","through","interaction","of","the","protein","(","s",")","with","a","interferon-stimulated","response","element","(","ISRE",")","in","the","DNA","."),4383018). assertion_content_comment('oboGo_ProteinDnaloadingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",",","to","drive","the","assembly","of","a","protein","or","protein","complex","onto","a","DNA","molecule","."),4193469). assertion_content_comment('oboGo_ProteinDnaRnacomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","DNA","molecules","to","form","a","protein-DNA","complex","."),4358214). assertion_content_comment('oboGo_ProteinDnaRnacomplexdisassembly',s("The","disaggregation","of","a","protein-DNA-RNA","complex","into","its","constituent","components","."),3980513). assertion_content_comment('oboGo_ProteinDnaRnacomplexremodeling',s("The","acquisition",",","loss",",","or","modification","of","macromolecules","within","a","complex",",","resulting","in","the","alteration","of","an","existing","complex","."),4358087). assertion_content_comment('oboGo_ProteinDnaRnacomplex',s("A","macromolecular","complex","containing","protein",",","DNA",",","and","RNA","molecules","."),4358204). assertion_content_comment('oboGo_ProteinDnaRnacomplexsubunitorganization',s("Any","process","in","which","macromolecules","aggregate",",","disaggregate",",","or","are","modified",",","resulting","in","the","formation",",","disassembly",",","or","alteration","of","a","protein-DNA-RNA","complex","."),3980510). assertion_content_comment('oboGo_ProteinExportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",";","drives","the","concomitant","secretion","of","proteins","."),4252488). assertion_content_comment('oboGo_ProteinFadlinkage',s("The","formation","of","a","linkage","between","a","protein","amino","acid","and","flavin-adenine","dinucleotide","(","FAD",")"),4280819). assertion_content_comment('oboGo_Protein_FADLinkageVia1_8alpha_FAD_L_Histidine',s("The","formation","of","a","protein-FAD","linkage","via","1","'","-","(","8-alpha-FAD",")","-L-histidine","."),4280925). assertion_content_comment('oboGo_Protein_FADLinkageVia3_8alpha_FAD_L_Histidine',s("The","formation","of","a","protein-FAD","linkage","via","3","'","-","(","8-alpha-FAD",")","-L-histidine","."),4280914). assertion_content_comment('oboGo_Protein_FADLinkageViaO4_8alpha_FAD_L_Tyrosine',s("The","formation","of","a","protein-FAD","linkage","via","O4","'","-","(","8-alpha-FAD",")","-L-tyrosine","."),4280903). assertion_content_comment('oboGo_Protein_FADLinkageViaS_8alpha_FAD_L_Cysteine',s("The","formation","of","a","protein-FAD","linkage","via","S-","(","8-alpha-FAD",")","-L-cysteine","."),4280830). assertion_content_comment('oboGo_ProteinFmnlinkage',s("The","formation","of","a","linkage","between","a","protein","amino","acid","and","flavin","mononucleotide","(","FMN",")"),4275696). assertion_content_comment('oboGo_Protein_FMNLinkageVia1_8alpha_FMN_L_Histidine',s("The","formation","of","a","protein-FMN","linkage","via","1","'","-","(","8alpha-FMN",")","-L-histidine","."),4275752). assertion_content_comment('oboGo_Protein_FMNLinkageVia3_8alpha_FMN_L_Histidine',s("The","formation","of","a","protein-FMN","linkage","via","3","'","-","(","8alpha-FMN",")","-L-histidine","."),4275762). assertion_content_comment('oboGo_ProteinFmnlinkageviao3RiboflavinphosphorylLSerine',s("The","formation","of","a","protein-FMN","linkage","via","O3-riboflavin","phosphoryl-L-serine","."),4275698). assertion_content_comment('oboGo_ProteinFmnlinkageviao3RiboflavinphosphorylLThreonine',s("The","formation","of","a","protein-FMN","linkage","via","O3-riboflavin","phosphoryl-L-threonine","."),4275718). assertion_content_comment('oboGo_Protein_FMNLinkageViaS_4a_FMN_L_Cysteine',s("The","formation","of","a","protein-FMN","linkage","via","S-","(","4a-FMN",")","-L-cysteine","."),4275708). assertion_content_comment('oboGo_Protein_FMNLinkageViaS_6_FMN_L_Cysteine',s("The","formation","of","a","protein-FMN","linkage","via","S-","(","6-FMN",")","-L-cysteine","."),4279433). assertion_content_comment('oboGo_ProteinGlucosylgalactosylhydroxylysineglucosidaseactivity',s("Catalysis","of","the","reaction",":","H2O","+","protein","alpha-D-glucosyl-1",",","2-beta-D-galactosyl-L-hydroxylysine","=","protein","beta-D-galactosyl-L-hydroxylysine","+","beta-D-glucose","."),4370432). assertion_content_comment('oboGo_ProteinGlutamatemethylesteraseactivity',s("Catalysis","of","the","reaction",":","protein","L-glutamate","O","(","5",")","-methyl","ester","+","H2O","=","protein","L-glutamate","+","methanol","."),4248074). assertion_content_comment('oboGo_ProteinGlutamateoMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","protein","L-glutamate","=","S-adenosyl-L-homocysteine","+","protein","L-glutamate","5-methyl","ester",";","this","reaction","is","the","methylation","of","peptidyl-L-glutamate","to","form","peptidyl-L-glutamate","5-methyl","ester","."),4248152). assertion_content_comment('oboGo_ProteinGlutamicacidligaseactivity',s("Catalysis","of","the","posttranslational","transfer","of","one","or","more","glutamate","residues","to","a","specific","residue","on","a","target","protein","."),4176149). assertion_content_comment('oboGo_ProteinGlutaminegammaGlutamyltransferaseactivity',s("Catalysis","of","the","reaction",":","protein","glutamine","+","alkylamine","=","protein","N5-alkylglutamine","+","NH3",".","This","reaction","is","the","formation","of","the","N6-","(","L-isoglutamyl",")","-L-lysine","isopeptide",",","resulting","in","cross-linking","polypeptide","chains",";","the","gamma-carboxamide","groups","of","peptidyl-glutamine","residues","act","as","acyl","donors",",","and","the","6-amino-groups","of","peptidyl-lysine","residues","act","as","acceptors",",","to","give","intra-","and","intermolecular","N6-","(","5-glutamyl",")","lysine","cross-links","."),4187720). assertion_content_comment('oboGo_ProteinGlutamineglutaminaseactivity',s("Catalysis","of","the","reaction",":","protein","L-glutamine","+","H2O","=","protein","L-glutamate","+","NH3","."),4268421). assertion_content_comment('oboGo_ProteinGlycineligaseactivityelongating',s("Catalysis","of","the","posttranslational","transfer","of","one","or","more","glycine","residues","to","a","glycine","residue","covalently","attached","to","the","gamma-carboxyl","group","of","a","glutamate","residue","on","a","target","protein",",","resulting","in","the","elongation","of","a","polyglycine","side","chain","."),4176183). assertion_content_comment('oboGo_ProteinGlycineligaseactivityinitiating',s("Catalysis","of","the","posttranslational","transfer","of","a","glycine","residue","to","the","gamma-carboxyl","group","(","s",")","of","one","or","more","specific","glutamate","residues","on","a","target","protein","."),4176193). assertion_content_comment('oboGo_ProteinGlycineligaseactivity',s("Catalysis","of","the","posttranslational","transfer","of","one","or","more","glycine","residues","to","a","specific","glutamate","residue","on","a","target","protein","."),4176180). assertion_content_comment('oboGo_ProteinHemelinkage',s("The","covalent","linkage","of","heme","and","a","protein","."),4265875). assertion_content_comment('oboGo_ProteinHemelinkagevia1LHistidine',s("The","covalent","linkage","of","heme","and","a","protein","via","1","'","-L-histidine","(","otherwise","known","as","tau-heme-histidine",",","tele-heme-histidine",")"),4357847). assertion_content_comment('oboGo_ProteinHemelinkagevia3LHistidine',s("The","covalent","linkage","of","heme","and","a","protein","via","3","'","-L-histidine","(","otherwise","known","as","pi-heme-histidine",",","pros-heme-histidine",")"),4285633). assertion_content_comment('oboGo_ProteinHemep460linkage',s("The","linkage","of","protein","to","heme","P460","."),4281983). assertion_content_comment('oboGo_ProteinHemep460linkageviahemep460BisLCysteineLLysine',s("The","linkage","of","protein","to","heme","P460","via","heme","P460-bis-L-cysteine-L-lysine","."),4281988). assertion_content_comment('oboGo_ProteinHemep460linkageviahemep460BisLCysteineLTyrosine',s("The","linkage","of","protein","to","heme","P460","via","heme","P460-bis-L-cysteine-L-tyrosine","."),4282181). assertion_content_comment('oboGo_ProteinHeparansulfatelinkageviaheparansulfatedGlucuronylDGalactosylDGalactosylDXylosylLSerine',s("Heparan","sulfate","components","are","covalently","linked","to","a","core","glycoprotein","via","O-glycosidic","linkages","between","xylose","and","serine","residues","."),4281336). assertion_content_comment('oboGo_ProteinHistidinenMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","protein","L-histidine","=","S-adenosyl-L-homocysteine","+","protein","N-methyl-L-histidine","."),4284263). assertion_content_comment('oboGo_ProteinHistidineProsKinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","protein","L-histidine","=","ADP","+","protein","N","(","pi",")","-phospho-L-histidine","."),4256034). assertion_content_comment('oboGo_ProteinHistidineTeleKinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","protein","L-histidine","=","ADP","+","protein","N","(","tau",")","-phospho-L-histidine","."),4256020). assertion_content_comment('oboGo_ProteinHormonereceptoractivity',s("Combining","with","a","protein","hormone","to","initiate","a","change","in","cell","activity","."),4071579). assertion_content_comment('oboGo_ProteinInsertionIntoERMembraneByInternalUncleavedSignalAnchorsequence',s("A","process","of","protein","insertion","into","the","endoplasmic","reticulum","(","ER",")","membrane","in","which","signal","anchor","sequences","function","as","both","ER","signal","sequences","and","membrane","anchor","sequences","."),4301059). assertion_content_comment('oboGo_ProteinInsertionIntoERMembraneByNTerminalcleavedsignalsequence',s("A","process","of","protein","insertion","into","the","endoplasmic","reticulum","(","ER",")","membrane","in","which","N-terminal","cleaved","signal","sequences","direct","polypeptides","to","the","ER","."),4300766). assertion_content_comment('oboGo_ProteinInsertionIntoERMembraneByStopTransfermembraneAnchorsequence',s("A","process","of","protein","insertion","into","the","endoplasmic","reticulum","(","ER",")","membrane","in","which","stop-transfer","membrane-anchor","sequences","become","an","ER","membrane","spanning","helix","."),4301081). assertion_content_comment('oboGo_ProteinK11Linkedubiquitination',s("A","protein","ubiquitination","process","in","which","ubiquitin","monomers","are","attached","to","a","protein",",","and","then","ubiquitin","polymers","are","formed","by","linkages","between","lysine","residues","at","position","11","of","the","ubiquitin","monomers",".","K11-linked","polyubiquitination","targets","the","substrate","protein","for","degradation",".","The","anaphase-promoting","complex","promotes","the","degradation","of","mitotic","regulators","by","assembling","K11-linked","polyubiquitin","chains","."),4177681). assertion_content_comment('oboGo_ProteinK27Linkedubiquitination',s("A","protein","ubiquitination","process","in","which","a","polymer","of","ubiquitin",",","formed","by","linkages","between","lysine","residues","at","position","27","of","the","ubiquitin","monomers",",","is","added","to","a","protein","."),4287920). assertion_content_comment('oboGo_ProteinK29Linkeddeubiquitination',s("A","protein","deubiquitination","process","in","which","a","K29-linked","ubiquitin","chain",",","i.e",".","a","polymer","of","ubiquitin","formed","by","linkages","between","lysine","residues","at","position","29","of","the","ubiquitin","monomers",",","is","removed","from","a","protein","."),4379067). assertion_content_comment('oboGo_ProteinK29Linkedubiquitination',s("A","protein","ubiquitination","process","in","which","a","polymer","of","ubiquitin",",","formed","by","linkages","between","lysine","residues","at","position","29","of","the","ubiquitin","monomers",",","is","added","to","a","protein",".","K29-linked","ubiquitination","targets","the","substrate","protein","for","degradation","."),4378934). assertion_content_comment('oboGo_ProteinK48Linkeddeubiquitination',s("A","protein","deubiquitination","process","in","which","a","K48-linked","ubiquitin","chain",",","i.e",".","a","polymer","of","ubiquitin","formed","by","linkages","between","lysine","residues","at","position","48","of","the","ubiquitin","monomers",",","is","removed","from","a","protein","."),4164502). assertion_content_comment('oboGo_ProteinK48Linkedubiquitination',s("A","protein","ubiquitination","process","in","which","a","polymer","of","ubiquitin",",","formed","by","linkages","between","lysine","residues","at","position","48","of","the","ubiquitin","monomers",",","is","added","to","a","protein",".","K48-linked","ubiquitination","targets","the","substrate","protein","for","degradation","."),4177967). assertion_content_comment('oboGo_ProteinK63Linkeddeubiquitination',s("A","protein","deubiquitination","process","in","which","a","K63-linked","ubiquitin","chain",",","i.e",".","a","polymer","of","ubiquitin","formed","by","linkages","between","lysine","residues","at","position","63","of","the","ubiquitin","monomers",",","is","removed","from","a","protein","."),4174528). assertion_content_comment('oboGo_ProteinK63Linkedubiquitination',s("A","protein","ubiquitination","process","in","which","a","polymer","of","ubiquitin",",","formed","by","linkages","between","lysine","residues","at","position","63","of","the","ubiquitin","monomers",",","is","added","to","a","protein",".","K63-linked","ubiquitination","does","not","target","the","substrate","protein","for","degradation",",","but","is","involved","in","several","pathways",",","notably","as","a","signal","to","promote","error-free","DNA","postreplication","repair","."),4174437). assertion_content_comment('oboGo_ProteinK6Linkeddeubiquitination',s("A","protein","deubiquitination","process","in","which","a","K6-linked","ubiquitin","chain",",","i.e",".","a","polymer","of","ubiquitin","formed","by","linkages","between","lysine","residues","at","position","6","of","the","ubiquitin","monomers",",","is","removed","from","a","protein","."),4287911). assertion_content_comment('oboGo_ProteinK6Linkedubiquitination',s("A","protein","ubiquitination","process","in","which","a","polymer","of","ubiquitin",",","formed","by","linkages","between","lysine","residues","at","position","6","of","the","ubiquitin","monomers",",","is","added","to","a","protein",".","K6-linked","ubiquitination","is","involved","in","DNA","repair","."),4080416). assertion_content_comment('oboGo_ProteinKeratansulfatelinkageviakeratansulfatedGlucuronylDGalactosylDGalactosylDXylosylLThreonine',s("Keratan","sulfate","components","are","covalently","linked","to","a","core","glycoprotein","via","O-glycosidic","linkages","between","xylose","and","threonine","residues","."),4281347). assertion_content_comment('oboGo_ProteinLipidcomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","lipids","to","form","a","protein-lipid","complex","."),3993979). assertion_content_comment('oboGo_ProteinLipidcomplexbinding',s("Interacting","selectively","and","non-covalently","with","a","protein-lipid","complex",",","any","macromolecular","complex","that","contains","both","protein","and","lipid","molecules","."),4171098). assertion_content_comment('oboGo_ProteinLipidcomplexdisassembly',s("The","disaggregation","of","a","protein-lipid","complex","into","its","constituent","components","."),4125691). assertion_content_comment('oboGo_ProteinLipidcomplexremodeling',s("The","acquisition",",","loss","or","modification","of","a","protein","or","lipid","within","a","protein-lipid","complex","."),4038025). assertion_content_comment('oboGo_ProteinLipidcomplex',s("A","macromolecular","complex","containing","both","protein","and","lipid","molecules","."),4075038). assertion_content_comment('oboGo_ProteinLipidcomplexsubunitorganization',s("Any","process","in","which","macromolecules","aggregate",",","disaggregate",",","or","are","modified",",","resulting","in","the","formation",",","disassembly",",","or","alteration","of","a","protein-lipid","complex","."),3993977). assertion_content_comment('oboGo_ProteinLIsoaspartatedAspartateoMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","protein","L-beta-aspartate","=","S-adenosyl-L-homocysteine","+","protein","L-beta-aspartate","methyl","ester","."),4201075). assertion_content_comment('oboGo_ProteinLocalizationToPreAutophagosomalstructure',s("Any","process","in","which","a","protein","is","transported","to",",","or","maintained","at",",","the","pre-autophagosomal","structure","(","PAS",")"),4357472). assertion_content_comment('oboGo_ProteinLysine6Oxidaseactivity',s("Catalysis","of","the","reaction",":","peptidyl-L-lysyl-peptide","+","H2O","+","O2","=","peptidyl-allysyl-peptide","+","NH3","+","hydrogen","peroxide","."),4200948). assertion_content_comment('oboGo_ProteinLysinelysylation',s("The","addition","of","lysine","group","to","a","lysine","residue","in","a","protein",",","producing","N6-","(","lysyl",")","-L-lysine",".","This","modification","is","observed","in",",","and","is","probably","unique","to",",","translation","elongation","factor","P","(","EF-P",")"),4125568). assertion_content_comment('oboGo_ProteinLysinenMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosyl-L-methionine","to","the","epsilon-amino","group","of","a","lysine","residue","in","a","protein","substrate","."),4283057). assertion_content_comment('oboGo_ProteinMethionineROxidereductaseactivity',s("Catalysis","of","the","reaction",":","L-methionine","R-oxide","+","thioredoxin","=","L-methionine","+","thioredoxin","disulfide",";","can","act","on","oxidized","methionine","in","peptide","linkage","with","specificity","for","the","R","enantiomer",".","Thioredoxin","disulfide","is","the","oxidized","form","of","thioredoxin","."),4363052). assertion_content_comment('oboGo_ProteinMethionineSOxidereductaseactivity',s("Catalysis","of","the","reaction",":","L-methionine","S-oxide","+","thioredoxin","=","L-methionine","+","thioredoxin","disulfide",";","can","act","on","oxidized","methionine","in","peptide","linkage","with","specificity","for","the","S","enantiomer",".","Thioredoxin","disulfide","is","the","oxidized","form","of","thioredoxin","."),4157840). assertion_content_comment('oboGo_ProteinN6LLysylLLysinemodificationtoproteinN6BetaLysylLLysine',s("The","modification","of","an","N6-","(","lysyl",")","-L-lysine","residue","in","a","protein",",","producing","protein-N6-","(","beta-lysyl",")","-L-lysine","(","(","2S",")","-2-amino-6-","(","[","(","2S",")","-2",",","6-diaminohexanoyl","]","amino",")","hexanoic","acid",")","This","modification","is","observed","in",",","and","is","probably","unique","to",",","translation","elongation","factor","P","(","EF-P",")"),4125969). assertion_content_comment('oboGo_ProteinNAcetylglucosaminyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-D-glucosamine","+","protein","=","UDP","+","4-N-","(","N-acetyl-D-glucosaminyl",")","-protein","."),4303621). assertion_content_comment('oboGo_ProteinNAcetylglucosaminyltransferasecomplex',s("Heterotrimeric","enzyme","complex",",","which","in","humans","is","composed","of","two","large","subunits","of","the","same","size",",","and","one","smaller","subunit",".","Functions","in","the","addition","of","nucleotide-activated","sugars","onto","the","polypeptide","."),4267550). assertion_content_comment('oboGo_ProteinNeddylationDuringNEDD8ClassDependentproteincatabolicprocess',s("OBSOLETE",".","Covalent","attachment","of","the","ubiquitin-like","protein","NEDD8","(","or","equivalent","protein",")","to","another","protein",",","as","a","part","of","NEDD8-dependant","protein","catabolism","."),4315569). assertion_content_comment('oboGo_ProteinNLinkedglucosylationviaasparagine',s("A","process","of","protein","N-linked","glycosylation","via","asparagine","in","which","glucose","is","added","to","the","N4","of","asparagine",",","forming","an","(","S",")","-2-amino-4-","(","D-glucopyranosyl",")","amino-4-oxobutanoic","acid","residue","."),4168175). assertion_content_comment('oboGo_ProteinNLinkedglycosylation',s("A","protein","glycosylation","process","in","which","a","sugar","unit","is","added","to","a","protein","via","the","N4","atom","of","peptidyl-asparagine",",","the","omega-N","of","arginine",",","or","the","N1","'","atom","peptidyl-tryptophan","."),4009794). assertion_content_comment('oboGo_ProteinNLinkedglycosylationviaarginine',s("The","glycosylation","of","protein","via","peptidyl-arginine",",","omega-N-glycosyl-L-arginine","."),4313139). assertion_content_comment('oboGo_ProteinNLinkedglycosylationviaasparagine',s("The","glycosylation","of","protein","via","the","N4","atom","of","peptidyl-asparagine","forming","N4-glycosyl-L-asparagine",";","the","most","common","form","is","N-acetylglucosaminyl","asparagine",";","N-acetylgalactosaminyl","asparagine","and","N4","glucosyl","asparagine","also","occur",".","This","modification","typically","occurs","in","extracellular","peptides","with","an","N-X-","(","ST",")","motif",".","Partial","modification","has","been","observed","to","occur","with","cysteine",",","rather","than","serine","or","threonine",",","in","the","third","position",";","secondary","structure","features","are","important",",","and","proline","in","the","second","or","fourth","positions","inhibits","modification","."),4168152). assertion_content_comment('oboGo_ProteinNLinkedglycosylationviatryptophan',s("The","glycosylation","of","protein","via","peptidyl-tryptophan",",","1","'","-glycosyl-L-tryptophan",";","results","in","the","formation","of","an","(","S",")","-2-amino-3-","(","1-D-mannopyranosyloxy-1H-indol-3-yl",")","propanoic","acid","residue","."),4280432). assertion_content_comment('oboGo_ProteinNLinkednAcetylgalactosaminylationviaasparagine',s("A","process","of","protein","N-linked","glycosylation","via","asparagine","in","which","N-acetylgalactosamine","is","added","to","the","N4","of","asparagine",",","forming","an","(","S",")","-2-amino-4-","(","2-acetamido-2-deoxy-beta-D-galactopyranosyl",")","amino-4-oxobutanoic","acid","residue","."),4168185). assertion_content_comment('oboGo_ProteinNLinkednAcetylglucosaminylationviaasparagine',s("A","process","of","protein","N-linked","glycosylation","via","asparagine","in","which","N-acetylglucosamine","is","added","to","the","N4","of","asparagine",",","forming","an","(","S",")","-2-amino-4-","(","2-acetamido-2-deoxy-beta-D-glucopyranosyl",")","amino-4-oxobutanoic","acid","residue","."),4168155). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineBetaGlucosidephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","beta-glucoside","(","out",")","=","protein","histidine","+","beta-glucoside","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333288). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineCellobiosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","cellobiose","(","out",")","=","protein","histidine","+","cellobiose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333169). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineFructosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","fructose","(","out",")","=","protein","histidine","+","fructose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333332). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineGalactitolphosphotransferasesystemtransmembranetransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","galactitol","(","out",")","=","protein","histidine","+","galactitol","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333180). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineGalactosaminephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","galactosamine","(","out",")","=","protein","histidine","+","galactosamine","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333321). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineGlucosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","glucose","(","out",")","=","protein","histidine","+","glucose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333136). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineLactosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","lactose","(","out",")","=","protein","histidine","+","lactose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333236). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineMaltosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","maltose","(","out",")","=","protein","histidine","+","maltose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333202). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineMannitolphosphotransferasesystemtransmembranetransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","mannitol","(","out",")","=","protein","histidine","+","mannitol","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333191). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineMannosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","mannose","(","out",")","=","protein","histidine","+","mannose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333213). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineNAcetylgalactosaminephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","N-acetylgalactosamine","(","out",")","=","protein","histidine","+","N-acetylgalactosamine","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333300). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineNAcetylglucosaminephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","N-acetylglucosamine","(","out",")","=","protein","histidine","+","N-acetylglucosamine","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333277). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineSorbitolphosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","sorbitol","(","out",")","=","protein","histidine","+","sorbitol","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333158). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineSorbosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","sorbose","(","out",")","=","protein","histidine","+","sorbose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333225). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineSucrosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","sucrose","(","out",")","=","protein","histidine","+","sucrose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333343). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineSugarphosphotransferaseactivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","sugar","(","out",")","=","protein","histidine","+","sugar","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4248118). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineSugarphosphotransferasecomplex',s("An","enzyme","complex","that","catalyzes","the","transfer","of","a","phosphate","from","protein","N","(","PI",")","-phosphohistidine","to","a","sugar","molecule",".","It","is","enzyme","II","of","the","phosphotransferase","system","."),4260203). assertion_content_comment('oboGo_ProteinNpiPhosphohistidineTrehalosephosphotransferasesystemtransporteractivity',s("Catalysis","of","the","PEP-dependent",",","phosphoryl","transfer-driven","transport","of","substances","across","a","membrane",".","The","transport","happens","by","catalysis","of","the","reaction",":","protein","N-phosphohistidine","+","trehalose","(","out",")","=","protein","histidine","+","trehalose","phosphate","(","in",")","This","differs","from","primary","and","secondary","active","transport","in","that","the","solute","is","modified","during","transport","."),4333354). assertion_content_comment('oboGo_ProteinNTerminalasparagineamidohydrolaseactivity',s("Catalysis","of","the","deamidation","of","an","N-terminal","asparagine","residue","in","a","peptide","or","protein","."),4255763). assertion_content_comment('oboGo_ProteinNTerminalglutamineamidohydrolaseactivity',s("Catalysis","of","the","deamidation","of","an","N-terminal","glutamin","residue","of","a","protein","."),4176374). assertion_content_comment('oboGo_ProteinNTerminusbinding',s("Interacting","selectively","and","non-covalently","with","a","protein","N-terminus",",","the","end","of","any","peptide","chain","at","which","the","2-amino","(","or","2-imino",")","function","of","a","constituent","amino","acid","is","not","attached","in","peptide","linkage","to","another","amino-acid","residue","."),4320539). assertion_content_comment('oboGo_ProteinOGlucuronidation',s("The","modification","of","a","protein","by","glucuronidation","on","an","amino","acid","oxygen","atom","."),4281557). assertion_content_comment('oboGo_ProteinOLinkedglycosylation',s("A","protein","glycosylation","process","in","which","a","sugar","unit","is","added","to","a","protein","via","the","hydroxyl","group","of","peptidyl-serine",",","peptidyl-threonine",",","peptidyl-hydroxylysine",",","or","peptidyl-hydroxyproline",",","or","via","the","phenol","group","of","peptidyl-tyrosine",",","forming","an","O-glycan","."),4038967). assertion_content_comment('oboGo_ProteinOLinkedglycosylationviahydroxylysine',s("The","glycosylation","of","protein","via","the","O5","atom","of","peptidyl-hydroxylysine",",","forming","O5-glycosyl-L-hydroxylysine",";","the","most","common","form","is","galactosyl","hydroxylysine","."),4280399). assertion_content_comment('oboGo_ProteinOLinkedglycosylationviahydroxyproline',s("The","glycosylation","of","proteins","via","04","atom","of","hydroxyproline","to","form","O4-glycosyl-L-hydroxyproline",";","the","most","common","form","is","arabinofuranosyl-4-proline","."),4280277). assertion_content_comment('oboGo_ProteinOLinkedglycosylationviaserine',s("The","glycosylation","of","protein","via","the","O3","atom","of","peptidyl-serine",",","forming","O3-glycosyl-L-serine",";","the","most","common","forms","are","N-acetylgalactosaminyl",",","mannosyl",",","galactosyl",",","and","xylosyl","serine","."),4038981). assertion_content_comment('oboGo_ProteinOLinkedglycosylationviathreonine',s("The","glycosylation","of","protein","via","the","O3","atom","of","peptidyl-threonine",",","forming","O3-glycosyl-L-threonine",";","the","most","common","forms","are","N-acetylgalactosaminyl",",","mannosyl",",","and","galactosyl","threonine","."),4280364). assertion_content_comment('oboGo_ProteinOLinkedglycosylationviatyrosine',s("The","glycosylation","of","protein","via","the","O4","'","atom","of","peptidyl-tyrosine",",","O4","'","-glycosyl-L-tyrosine",";","the","carbohydrate","is","glucose",",","the","origin","for","glycogen","."),4280444). assertion_content_comment('oboGo_ProteinOLinkedmannosylation',s("The","transfer","of","mannose","from","dolichyl","activated","mannose","to","the","hydroxyl","group","of","a","seryl","or","threonyl","residue","of","a","protein","acceptor","molecule",",","to","form","an","O-linked","protein-sugar","linkage","."),4382661). assertion_content_comment('oboGo_ProteinPeptidylProlylisomerization',s("The","modification","of","a","protein","by","cis-trans","isomerization","of","a","proline","residue","."),4362786). assertion_content_comment('oboGo_ProteinPhosphateLinkedglycosylation',s("The","glycosylation","of","peptidyl-amino","acids","through","a","phosphoester","bond","forming",",","for","example",",","GlcNAc-alpha-1-P-Ser","residues","."),4281844). assertion_content_comment('oboGo_ProteinPhosphateLinkedglycosylationviaserine',s("The","glycosylation","of","peptidyl-serine","through","a","phosphoester","bond","forming",",","for","example",",","GlcNAc-alpha-1-P-Ser","residues","."),4281848). assertion_content_comment('oboGo_ProteinPhosphoribosyldephosphoCoenzymealinkage',s("The","linkage","of","phosphoribosyl","dephospho-coenzyme","A","to","protein","via","peptidyl-serine",",","to","form","O-","(","phosphoribosyl","dephospho-coenzyme","A",")","-L-serine",";","it","is","uncertain","whether","the","phosphoribosyl","glycosidic","attachment","to","the","dephospho-coenzyme","A","is","alpha","or","beta",",","and","through","the","2","'","or","the","3","'","position","."),4280421). assertion_content_comment('oboGo_ProteinPhosphoribosyldephosphoCoenzymealinkageviaoPhosphoribosyldephosphoCoenzymeaLSerine',s("The","formation","of","a","protein-phosphoribosyl","dephospho-coenzyme","A","linkage","via","O-","(","phosphoribosyl","dephospho-coenzyme","A",")","-L-serine","."),4282192). assertion_content_comment('oboGo_ProteinPhycobiliviolinlinkage',s("The","linkage","of","the","chromophore","phycobiliviolin","to","phycoerythrocyanin","."),4265915). assertion_content_comment('oboGo_ProteinPhycobiliviolinlinkageviasPhycobiliviolinLCysteine',s("The","linkage","of","the","chromophore","phycobiliviolin","to","phycoerythrocyanin","via","S-phycobiliviolin-L-cysteine","."),4282203). assertion_content_comment('oboGo_ProteinPhycocyanobilinlinkage',s("The","linkage","of","the","chromophore","phycocyanobilin","to","phycocyanin","or","allophycocyanin","."),4265905). assertion_content_comment('oboGo_ProteinPhycocyanobilinlinkageviasPhycocyanobilinLCysteine',s("The","linkage","of","the","chromophore","phycocyanobilin","to","phycocyanin","or","allophycocyanin","via","S-phycocyanobilin-L-cysteine","."),4282227). assertion_content_comment('oboGo_ProteinPhycoerythrobilinlinkage',s("The","linkage","of","the","chromophore","phycoerythrobilin","to","phycoerythrins","."),4268958). assertion_content_comment('oboGo_ProteinPhycoerythrobilinlinkageviaphycoerythrobilinBisLCysteine',s("The","linkage","of","the","chromophore","phycoerythrobilin","to","phycoerythrin","via","phycoerythrobilin-bis-L-cysteine","."),4284566). assertion_content_comment('oboGo_ProteinPhycoerythrobilinlinkageviasPhycoerythrobilinLCysteine',s("The","linkage","of","the","chromophore","phycoerythrobilin","to","phycoerythrocyanin","via","S-phycoerythrobilin-L-cysteine","."),4284555). assertion_content_comment('oboGo_ProteinPhycourobilinlinkage',s("The","linkage","of","the","chromophore","phycourobilin","to","phycoerythrins","."),4268948). assertion_content_comment('oboGo_ProteinPhycourobilinlinkageviaphycourobilinBisLCysteine',s("The","linkage","of","the","chromophore","phycourobilin","to","phycoerythrins","via","phycourobilin-bis-L-cysteine","."),4282215). assertion_content_comment('oboGo_ProteinPhytochromobilinlinkage',s("The","linkage","of","the","chromophore","phytochromobilin","to","phycocyanin","or","allophycocyanin","."),4268927). assertion_content_comment('oboGo_ProteinPhytochromobilinlinkageviasPhytochromobilinLCysteine',s("The","linkage","of","the","chromophore","phytochromobilin","to","phycocyanin","or","allophycocyanin","via","S-phytochromobilin-L-cysteine","."),4282168). assertion_content_comment('oboGo_ProteinPiiuridylyltransferaseactivity',s("Catalysis","of","the","reaction",":","UTP","+","(","protein-PII",")","=","diphosphate","+","uridylyl-","(","protein-PII",")"),4251843). assertion_content_comment('oboGo_ProteinPolyAdpRibosylation',s("The","transfer","of","multiple","ADP-ribose","residues","from","NAD","to","a","protein","amino","acid",",","forming","a","poly","(","ADP-ribose",")","chain","."),4174020). assertion_content_comment('oboGo_Protein_Pyridoxal_5_PhosphateLinkage',s("The","formation","of","a","linkage","between","a","protein","amino","acid","and","pyridoxal-5-phosphate","."),4280490). assertion_content_comment('oboGo_Protein_Pyridoxal_5_PhosphateLinkageViaPeptidyl_N6_PyridoxalPhosphate_L_Lysine',s("The","modification","of","peptidyl-lysine","to","form","N6-pyridoxal","phosphate-L-lysine","."),4280492). assertion_content_comment('oboGo_ProteinPyrroloquinolineQuinonelinkage',s("OBSOLETE",".","The","covalent","cross-linking","of","pyrroloquinoline-quinone","to","peptidyl-glutamic","acid","and","peptidyl-tyrosine","."),4279387). assertion_content_comment('oboGo_ProteinSelfAssociation',s("Interacting","selectively","and","non-covalently","with","a","domain","within","the","same","polypeptide","."),4325382). assertion_content_comment('oboGo_ProteinSerineepimeraseactivity',s("Catalysis","of","the","reaction",":","(","protein",")","-L-serine","=","(","protein",")","-D-serine","."),4282069). assertion_content_comment('oboGo_ProteinSLinkedglycosylation',s("A","protein","glycosylation","process","in","which","a","sugar","unit","is","added","to","a","protein","via","a","sulfur","atom","of","a","peptidyl-amino-acid","such","as","cysteine","or","methionine","."),4280384). assertion_content_comment('oboGo_ProteinSLinkedglycosylationviacysteine',s("The","glycosylation","of","protein","via","the","sulfur","atom","of","peptidyl-cysteine",",","forming","S-glycosyl-L-cysteine","."),4280387). assertion_content_comment('oboGo_ProteinSynthesizinggtpaseactivityelongation',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate","."),4303061). assertion_content_comment('oboGo_ProteinSynthesizinggtpaseactivityinitiation',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate","."),4303085). assertion_content_comment('oboGo_ProteinSynthesizinggtpaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate",".","A","GTPase","involved","in","protein","synthesis",".","In","the","initiation","factor","complex",",","it","is","IF-2b","(","98","kDa",")","that","binds","GTP","and","subsequently","hydrolyzes","it","in","prokaryotes",".","In","eukaryotes",",","it","is","eIF-2","(","150","kDa",")","that","binds","GTP",".","In","the","elongation","phase",",","the","GTP-hydrolyzing","proteins","are","the","EF-Tu","polypeptide","of","the","prokaryotic","transfer","factor","(","43","kDa",")",",","the","eukaryotic","elongation","factor","EF-1a","(","53","kDa",")",",","the","prokaryotic","EF-G","(","77","kDa",")",",","the","eukaryotic","EF-2","(","70-110","kDa",")","and","the","signal","recognition","particle","that","play","a","role","in","endoplasmic","reticulum","protein","synthesis","(","325","kDa",")","EF-Tu","and","EF1a","catalyze","binding","of","aminoacyl-tRNA","to","the","ribosomal","A-site",",","while","EF-G","and","EF-2","catalyze","the","translocation","of","peptidyl-tRNA","from","the","A-site","to","the","P-site",".","GTPase","activity","is","also","involved","in","polypeptide","release","from","the","ribosome","with","the","aid","of","the","pRFs","and","eRFs","."),4252644). assertion_content_comment('oboGo_ProteinSynthesizinggtpaseactivitytermination',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate","."),4303047). assertion_content_comment('oboGo_ProteinTargetingToMembraneInvolvedInUbiquitinDependentproteincatabolicprocessviathemultivesicularbodysortingpathway',s("The","process","of","directing","proteins","towards","a","membrane","using","signals","contained","within","the","protein",",","occurring","that","contributes","to","ubiquitin-dependent","protein","catabolism","via","the","MVB","pathway",";","the","destruction","of","a","protein","or","peptide","covalently","tagged","with","a","ubiquitin",",","via","the","multivesicular","body","(","MVB",")","sorting","pathway","."),4095622). assertion_content_comment('oboGo_ProteinTargetingToVacuoleInvolvedInUbiquitinDependentproteincatabolicprocessviathemultivesicularbodysortingpathway',s("The","process","of","directing","proteins","towards","the","vacuole","using","signals","contained","within","the","protein",",","occurring","that","contributes","to","protein","catabolism","via","the","multivesicular","body","(","MVB",")","pathway","."),4095663). assertion_content_comment('oboGo_ProteinTetrapyrrolelinkage',s("The","covalent","linking","of","a","tetrapyrrole","to","a","protein","."),4265873). assertion_content_comment('oboGo_ProteinThiolDisulfideexchange',s("Oxidation","of","two","organic","sulfhydryl","groups","(","thiols",")","by","a","disulfide","compound","to","form","a","disulfide","bond",",","according","to","the","reaction","RS-SR","+","R","'","SH","=","R","'","S-SR","+","RSH","."),4223985). assertion_content_comment('oboGo_ProteinTransmembranetransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","protein","(","out",")","=","ADP","+","phosphate","+","protein","(","in",")"),4252483). assertion_content_comment('oboGo_ProteinTyrosinePhosphataseActivityMetalDependent',s("Catalysis","of","the","reaction",":","protein","tyrosine","phosphate","+","H2O","=","protein","tyrosine","+","phosphate",".","This","reaction","requires","metal","ions","."),4307472). assertion_content_comment('oboGo_ProteinTyrosinePhosphataseActivityViaThiolPhosphateintermediate',s("The","catalysis","of","phosphate","removal","from","a","phosphotyrosine","using","cysteine","as","a","nucleophile","and","proceed","by","means","of","a","thiol-phosphate","intermediate","."),4307463). assertion_content_comment('oboGo_ProteinTyrosinesulfotransferaseactivity',s("Catalysis","of","the","reaction",":","3","'","-phosphoadenosine","5","'","-phosphosulfate","+","protein","tyrosine","=","adenosine","3","'",",","5","'","-bisphosphate","+","protein","tyrosine-O-sulfate","."),4254270). assertion_content_comment('oboGo_ProteinUbiquitinationInvolvedInUbiquitinDependentproteincatabolicprocess',s("The","process","in","which","a","ubiquitin","group",",","or","multiple","groups",",","are","covalently","attached","to","the","target","protein",",","thereby","initiating","the","degradation","of","that","protein","."),4077398). assertion_content_comment('oboGo_ProtoaphinAgluconedehydratasecyclizingactivity',s("Catalysis","of","the","reaction",":","protoaphin","aglucone","=","H","(","2",")","O","+","xanthoaphin","."),4369443). assertion_content_comment('oboGo_ProtocadherinAlphaProtocadherinGammacomplex',s("A","protein","complex","that","contains","two","cell","adhesion","molecules",",","a","protocadherin-alpha","and","a","protocadherin-gamma",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4164981). assertion_content_comment('oboGo_ProtocadherinAlphaV4ProtocadherinGammaA1complex',s("A","protein","complex","that","contains","the","cell","adhesion","molecules","protocadherin-alpha-v4","and","protocadherin-gamma-a1",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4165011). assertion_content_comment('oboGo_ProtocadherinAlphaV4ProtocadherinGammaA3complex',s("A","protein","complex","that","contains","the","cell","adhesion","molecules","protocadherin-alpha-v4","and","protocadherin-gamma-a3",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4165001). assertion_content_comment('oboGo_ProtocadherinAlphaV4ProtocadherinGammaB2complex',s("A","protein","complex","that","contains","the","cell","adhesion","molecules","protocadherin-alpha-v4","and","protocadherin-gamma-b2",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4165031). assertion_content_comment('oboGo_ProtocadherinAlphaV4ProtocadherinGammaB4complex',s("A","protein","complex","that","contains","the","cell","adhesion","molecules","protocadherin-alpha-v4","and","protocadherin-gamma-b4",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4165021). assertion_content_comment('oboGo_ProtocadherinAlphaV7ProtocadherinGammaA1complex',s("A","protein","complex","that","contains","the","cell","adhesion","molecules","protocadherin-alpha-v7","and","protocadherin-gamma-a1",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4165130). assertion_content_comment('oboGo_ProtocadherinAlphaV7ProtocadherinGammaA3complex',s("A","protein","complex","that","contains","the","cell","adhesion","molecules","protocadherin-alpha-v7","and","protocadherin-gamma-a3",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4165120). assertion_content_comment('oboGo_ProtocadherinAlphaV7ProtocadherinGammaB2complex',s("A","protein","complex","that","contains","the","cell","adhesion","molecules","protocadherin-alpha-v7","and","protocadherin-gamma-b2",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4165140). assertion_content_comment('oboGo_ProtocadherinAlphaV7ProtocadherinGammaB4complex',s("A","protein","complex","that","contains","the","cell","adhesion","molecules","protocadherin-alpha-v7","and","protocadherin-gamma-b4",",","and","is","involved","in","the","regulation","of","protein","localization","to","the","plasma","membrane","."),4165199). assertion_content_comment('oboGo_Protocatechuate34Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","3",",","4-dihydroxybenzoate","+","O2","=","3-carboxy-cis",",","cis-muconate","."),4278652). assertion_content_comment('oboGo_Protocatechuate34Dioxygenasetypeiiactivity',s("Catalysis","of","the","reaction",":","4-sulfocatechol","+","O2","=","3-sulfomuconate","."),4278818). assertion_content_comment('oboGo_Protocatechuate45Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","protocatechuate","+","O2","=","4-carboxy-2-hydroxymuconate","semialdehyde","."),4278667). assertion_content_comment('oboGo_ProtocatechuateCatabolicProcessMetaCleavage',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","protocatechuate",",","the","anion","of","3",",","4-dihydroxybenzoic","acid",",","to","yield","oxaloacetate","and","pyruvate","."),4243739). assertion_content_comment('oboGo_ProtocatechuateCatabolicProcessOrthoCleavage',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","protocatechuate",",","the","anion","of","3",",","4-dihydroxybenzoic","acid",",","to","yield","beta-ketoadipate","."),4243764). assertion_content_comment('oboGo_ProtonDependentoligopeptidesecondaryactivetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","oligopeptide","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","proton","movement","."),4219675). assertion_content_comment('oboGo_ProtonDependentpeptidesecondaryactivetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","peptide","from","one","side","of","a","membrane","to","the","other",",","up","its","concentration","gradient",".","The","transporter","binds","the","solute","and","undergoes","a","series","of","conformational","changes",".","Transport","works","equally","well","in","either","direction","and","is","driven","by","proton","movement","."),4296309). assertion_content_comment('oboGo_ProtonTransportingatpaseactivityrotationalmechanism',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","H","+","(","in",")","=","ADP","+","phosphate","+","H","+","(","out",")",",","by","a","rotational","mechanism","."),4185956). assertion_content_comment('oboGo_ProtonTransportingatpsynthasecatalyticcore',s("The","hexamer","that","possesses","the","catalytic","activity","of","the","mitochondrial","hydrogen-transporting","ATP","synthase","."),4007495). assertion_content_comment('oboGo_ProtonTransportingatpsynthasecentralstalk',s("One","of","two","stalks","that","connect","the","catalytic","core","of","the","hydrogen-transporting","ATP","synthase","to","the","membrane-associated","Fo","proteins",";","rotates","within","the","catalytic","core","during","catalysis","."),4007802). assertion_content_comment('oboGo_ProtonTransportingatpsynthasecomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","proton-transporting","ATP","synthase","(","also","known","as","F-type","ATPase",")",",","a","two-sector","ATPase","found","in","the","inner","membrane","of","mitochondria","and","chloroplasts",",","and","in","bacterial","plasma","membranes","."),4063541). assertion_content_comment('oboGo_ProtonTransportingatpsynthasecomplexbiogenesis',s("The","biogenesis","of","a","proton-transporting","ATP","synthase","(","also","known","as","F-type","ATPase",")",",","a","two-sector","ATPase","found","in","the","inner","membrane","of","mitochondria","and","chloroplasts",",","and","in","bacterial","plasma","membranes",".","Includes","the","synthesis","of","constituent","proteins","and","their","aggregation",",","arrangement","and","bonding","together","."),4063538). assertion_content_comment('oboGo_ProtonTransportingatpsynthasecomplexcatalyticcoref1',s("The","sector","of","a","hydrogen-transporting","ATP","synthase","complex","in","which","the","catalytic","activity","resides",";","it","comprises","the","catalytic","core","and","central","stalk",",","and","is","peripherally","associated","with","a","membrane",",","such","as","the","plasma","membrane","or","the","mitochondrial","inner","membrane",",","when","the","entire","ATP","synthase","is","assembled","."),3974155). assertion_content_comment('oboGo_ProtonTransportingatpsynthasecomplexcouplingfactorfo',s("All","non-F1","subunits","of","a","hydrogen-transporting","ATP","synthase",",","including","integral","and","peripheral","membrane","proteins","."),3974181). assertion_content_comment('oboGo_ProtonTransportingatpsynthasecomplex',s("A","proton-transporting","two-sector","ATPase","complex","that","catalyzes","the","phosphorylation","of","ADP","to","ATP","during","oxidative","phosphorylation",".","The","complex","comprises","a","membrane","sector","(","F0",")","that","carries","out","proton","transport","and","a","cytoplasmic","compartment","sector","(","F1",")","that","catalyzes","ATP","synthesis","by","a","rotational","mechanism",";","the","extramembrane","sector","(","containing","3","a","and","3","b","subunits",")","is","connected","via","the","d-subunit","to","the","membrane","sector","by","several","smaller","subunits",".","Within","this","complex",",","the","g","and","e","subunits","and","the","9-12","c","subunits","rotate","by","consecutive","120","degree","angles","and","perform","parts","of","ATP","synthesis",".","This","movement","is","driven","by","the","hydrogen","ion","electrochemical","potential","gradient","."),3974103). assertion_content_comment('oboGo_ProtonTransportingatpsynthasestatorstalk',s("One","of","two","stalks","that","connect","the","catalytic","core","of","the","hydrogen-transporting","ATP","synthase","to","the","membrane-associated","Fo","proteins",";","is","thought","to","prevent","futile","rotation","of","the","catalytic","core","."),3974209). assertion_content_comment('oboGo_ProtonTransportingtwoSectoratpasecomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","proton-transporting","two-sector","ATPase","complex",",","a","large","protein","complex","that","catalyzes","the","synthesis","or","hydrolysis","of","ATP","by","a","rotational","mechanism",",","coupled","to","the","transport","of","protons","across","a","membrane","."),4063527). assertion_content_comment('oboGo_ProtonTransportingtwoSectoratpasecomplexcatalyticdomain',s("A","protein","complex","that","forms","part","of","a","proton-transporting","two-sector","ATPase","complex","and","catalyzes","ATP","hydrolysis","or","synthesis",".","The","catalytic","domain","(","F1",",","V1",",","or","A1",")","comprises","a","hexameric","catalytic","core","and","a","central","stalk",",","and","is","peripherally","associated","with","the","membrane","when","the","two-sector","ATPase","is","assembled","."),3973247). assertion_content_comment('oboGo_ProtonTransportingtwoSectoratpasecomplexprotonTransportingdomain',s("A","protein","complex","that","forms","part","of","a","proton-transporting","two-sector","ATPase","complex","and","carries","out","proton","transport","across","a","membrane",".","The","proton-transporting","domain","(","F0",",","V0",",","or","A0",")","includes","integral","and","peripheral","membrane","proteins","."),3973370). assertion_content_comment('oboGo_ProtonTransportingtwoSectoratpasecomplex',s("A","large","protein","complex","that","catalyzes","the","synthesis","or","hydrolysis","of","ATP","by","a","rotational","mechanism",",","coupled","to","the","transport","of","protons","across","a","membrane",".","The","complex","comprises","a","membrane","sector","(","F0",",","V0",",","or","A0",")","that","carries","out","proton","transport","and","a","cytoplasmic","compartment","sector","(","F1",",","V1",",","or","A1",")","that","catalyzes","ATP","synthesis","or","hydrolysis",".","Two","major","types","have","been","characterized",":","V-type","ATPases","couple","ATP","hydrolysis","to","the","transport","of","protons","across","a","concentration","gradient",",","whereas","F-type","ATPases",",","also","known","as","ATP","synthases",",","normally","run","in","the","reverse","direction","to","utilize","energy","from","a","proton","concentration","or","electrochemical","gradient","to","synthesize","ATP",".","A","third","type",",","A-type","ATPases","have","been","found","in","archaea",",","and","are","closely","related","to","eukaryotic","V-type","ATPases","but","are","reversible","."),3973243). assertion_content_comment('oboGo_ProtonTransportingvTypeatpasecomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","proton-transporting","V-type","ATPase","complex",",","proton-transporting","two-sector","ATPase","complex","that","couples","ATP","hydrolysis","to","the","transport","of","protons","across","a","concentration","gradient","."),4180150). assertion_content_comment('oboGo_ProtonTransportingvTypeatpasecomplex',s("A","proton-transporting","two-sector","ATPase","complex","that","couples","ATP","hydrolysis","to","the","transport","of","protons","across","a","concentration","gradient",".","The","resulting","transmembrane","electrochemical","potential","of","H","+","is","used","to","drive","a","variety","of","(","i",")","secondary","active","transport","systems","via","H","+","-dependent","symporters","and","antiporters","and","(","ii",")","channel-mediated","transport","systems",".","The","complex","comprises","a","membrane","sector","(","V0",")","that","carries","out","proton","transport","and","a","cytoplasmic","compartment","sector","(","V1",")","that","catalyzes","ATP","hydrolysis",".","V-type","ATPases","are","found","in","the","membranes","of","organelles","such","as","vacuoles",",","endosomes",",","and","lysosomes",",","and","in","the","plasma","membrane","."),3973257). assertion_content_comment('oboGo_ProtonTransportingvTypeatpasev0domain',s("A","protein","complex","that","forms","part","of","a","proton-transporting","V-type","ATPase","and","mediates","proton","transport","across","a","membrane",".","The","V0","complex","consists","of","at","least","four","different","subunits","(","a",",","c",",","d","and","e",")",";","six","or","more","c","subunits","form","a","proton-binding","rotor","ring","."),3973373). assertion_content_comment('oboGo_ProtonTransportingvTypeatpasev1domain',s("A","protein","complex","that","forms","part","of","a","proton-transporting","V-type","ATPase","and","catalyzes","ATP","hydrolysis",".","The","V1","complex","consists","of",":","(","1",")","a","globular","headpiece","with","three","alternating","copies","of","subunits","A","and","B","that","form","a","ring",",","(","2",")","a","central","rotational","stalk","composed","of","single","copies","of","subunits","D","and","F",",","and","(","3",")","a","peripheral","stalk","made","of","subunits","C",",","E",",","G","and","H",".","Subunits","A","and","B","mediate","the","hydrolysis","of","ATP","at","three","reaction","sites","associated","with","subunit","A","."),3973260). assertion_content_comment('oboGo_Protopine6Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADPH","+","O","(","2",")","+","protopine","=","6-hydroxyprotopine","+","H","(","2",")","O","+","NADP","(","+",")"),4364981). assertion_content_comment('oboGo_ProXcarboxypeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","a","Pro-Xaa","bond","to","release","a","C-terminal","amino","acid","."),4255231). assertion_content_comment('oboGo_ProXmetallocarboxypeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","a","Pro-Xaa","bond","by","a","metallopeptidase","mechanism","to","release","a","C-terminal","amino","acid","."),4319703). assertion_content_comment('oboGo_PrunasinBetaGlucosidaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-prunasin","+","H","(","2",")","O","=","D-glucose","+","mandelonitrile","."),4263438). assertion_content_comment('oboGo_PSIAssociatedLightHarvestingcomplexilhciasubcomplex',s("A","pigment","protein","complex","that","forms","part","of","the","photosystem","I","associated","light-harvesting","complex","I",";","contains","two","proteins","(","usually","about","24","and","21.5","kDa",")",";","has","a","fluorescence","maximum","between","680","and","690","nm","."),4306734). assertion_content_comment('oboGo_PSIAssociatedLightHarvestingcomplexilhcibsubcomplex',s("A","pigment","protein","complex","that","forms","part","of","the","photosystem","I","associated","light-harvesting","complex","I",";","contains","two","proteins","(","usually","about","20","kDa",")",";","has","a","fluorescence","maximum","of","730","nm","."),4306714). assertion_content_comment('oboGo_PSIAssociatedLightHarvestingcomplexi',s("Protein-pigment","complex","associated","with","photosystem","I","."),4261709). assertion_content_comment('oboGo_PSIIAssociatedLightHarvestingcomplexiicatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","one","or","more","components","of","the","light-harvesting","complex","of","photosystem","II","."),4027906). assertion_content_comment('oboGo_PSIIAssociatedLightHarvestingcomplexiicorecomplexlhciiasubcomplex',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4306694). assertion_content_comment('oboGo_PSIIAssociatedLightHarvestingcomplexiicorecomplexlhciicsubcomplex',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4306705). assertion_content_comment('oboGo_PSIIAssociatedLightHarvestingcomplexiicorecomplexlhciidsubcomplex',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4306725). assertion_content_comment('oboGo_PSIIAssociatedLightHarvestingcomplexiicorecomplex',s("The","pigment-protein","complex","primarily","associated","to","PSII","in","higher","plants",",","green","algae","and","cyanobacteria","that","directly","transfers","electrons","to","the","reaction","center","."),4022779). assertion_content_comment('oboGo_PSIIAssociatedLightHarvestingcomplexiiperipheralcomplexlhciibsubcomplex',s("A","pigment","protein","complex","that","forms","part","of","the","photosystem","II","associated","light-harvesting","complex","II",";","contains","two","proteins","(","usually","about","28","and","27","kDa",")",",","and","may","contain","a","third",";","peripherally","located","relative","to","other","LHC","polypeptides","."),4052887). assertion_content_comment('oboGo_PSIIAssociatedLightHarvestingcomplexiiperipheralcomplex',s("Pigment-protein","complex","primarily","associated","to","PSII","in","plants",",","green","algae","and","cyanobacteria",".","Involved","in","state","transitions","that","cause","migration","to","PSI","under","certain","environmental","conditions","such","as","high","light","."),4022796). assertion_content_comment('oboGo_PSIIAssociatedLightHarvestingcomplexii',s("Protein-pigment","complex","associated","with","photosystem","II","."),4022764). assertion_content_comment('oboGo_PTefbCapmethyltransferasecomplexlocalization',s("Any","process","in","which","the","P-TEFb-cap","methyltransferase","complex","is","transported","to",",","or","maintained","in",",","a","specific","location","."),4179083). assertion_content_comment('oboGo_PTefbCapmethyltransferasecomplex',s("A","protein","complex","that","is","formed","by","the","association","of","positive","transcription","elongation","factor","complex","b","(","P-TEFb",")","with","the","mRNA","capping","methyltransferase","."),4177524). assertion_content_comment('oboGo_PteridineContainingcompoundbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","compound","containing","pteridine","(","pyrazino","(","2",",","3-dipyrimidine",")",")",",","e.g",".","pteroic","acid",",","xanthopterin","and","folic","acid","."),4229456). assertion_content_comment('oboGo_PteridineContainingcompoundcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","compound","containing","pteridine","(","pyrazino","(","2",",","3-dipyrimidine",")",")",",","e.g",".","pteroic","acid",",","xanthopterin","and","folic","acid","."),4233193). assertion_content_comment('oboGo_PteridineContainingcompoundmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","any","compound","containing","pteridine","(","pyrazino","(","2",",","3-dipyrimidine",")",")",",","e.g",".","pteroic","acid",",","xanthopterin","and","folic","acid","."),4080141). assertion_content_comment('oboGo_PulegonereductaseIsomenthoneassubstrateactivity',s("Catalysis","of","the","reaction",":","(","+",")","-isomenthone","+","NADP","+","=","(","+",")","-pulegone","+","NADPH","+","H","+"),4186508). assertion_content_comment('oboGo_PulegonereductaseMenthoneassubstrateactivity',s("Catalysis","of","the","reaction",":","(","-",")","-menthone","+","NADP","+","=","(","+",")","-pulegone","+","NADPH","+","H","+"),4186383). assertion_content_comment('oboGo_PupalChitinBasedcuticledevelopment',s("Synthesis","and","deposition","of","a","chitin-based","pupal","cuticle",".","At","the","end","of","the","prepupal","period","the","insect","is","covered","by","the","pupal","cuticle","which","continues","to","be","elaborated","into","the","pupal","period",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4020704). assertion_content_comment('oboGo_PurineContainingcompoundbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","purine-containing","compound",",","i.e",".","any","compound","that","contains","purine","or","a","formal","derivative","thereof","."),4027700). assertion_content_comment('oboGo_PurineContainingcompoundcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","purine-containing","compound",",","i.e",".","any","compound","that","contains","purine","or","a","formal","derivative","thereof","."),4005182). assertion_content_comment('oboGo_PurineContainingcompoundmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","a","purine-containing","compound",",","i.e",".","any","compound","that","contains","purine","or","a","formal","derivative","thereof","."),4005091). assertion_content_comment('oboGo_PurineContainingcompoundsalvage',s("Any","process","that","generates","a","purine-containing","compound",",","any","nucleobase",",","nucleoside",",","nucleotide","or","nucleic","acid","that","contains","a","purine","base",",","from","derivatives","of","them","without","de","novo","synthesis","."),4227206). assertion_content_comment('oboGo_PurineContainingcompoundtransmembranetransport',s("The","directed","movement","of","a","purine-containing","compound","across","a","membrane",".","A","purine-containing","compound","is","any","compound","that","contains","purine","or","a","formal","derivative","thereof","."),4053848). assertion_content_comment('oboGo_PurineImidazoleRingcyclaseactivity',s("Catalysis","of","the","reaction",":","DNA","4",",","6-diamino-5-formamidopyrimidine","=","DNA","adenine","+","H2O","."),4263489). assertion_content_comment('oboGo_PurineNTPDependenthelicaseactivity',s("Catalysis","of","the","reaction",":","purine","NTP","+","H2O","=","purine","NDP","+","phosphate",",","to","drive","the","unwinding","of","a","DNA","or","RNA","helix","."),4180579). assertion_content_comment('oboGo_PurineNucleosidephosphorylaseactivity',s("Catalysis","of","the","reaction",":","purine","nucleoside","+","phosphate","=","purine","+","alpha-D-ribose","1-phosphate","."),4200755). assertion_content_comment('oboGo_PurinergicNucleotideReceptorActivityGProteincoupled',s("Combining","with","a","purine","nucleotide","and","transmitting","the","signal","to","a","heterotrimeric","G-protein","complex","to","initiate","a","change","in","cell","activity","."),4300718). assertion_content_comment('oboGo_PurineRichnegativeregulatoryelementbinding',s("Interacting","selectively","and","non-covalently","with","a","30-bp","purine-rich","negative","regulatory","element",";","the","best","characterized","such","element","is","found","in","the","first","intronic","region","of","the","rat","cardiac","alpha-myosin","heavy","chain","gene",",","and","contains","two","palindromic","high-affinity","Ets-binding","sites","(","CTTCCCTGGAAG",")","The","presence","of","this","element","restricts","expression","of","the","gene","containing","it","to","cardiac","myocytes","."),4335066). assertion_content_comment('oboGo_PurineSpecificmismatchbasepairdnanGlycosylaseactivity',s("Catalysis","of","the","removal","of","purines","present","in","mismatches",",","especially","opposite","oxidized","purines",",","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","target","damaged","DNA","base","and","the","deoxyribose","sugar",".","The","reaction","releases","a","free","base","and","leaves","an","apurinic","(","AP",")","site","."),4363786). assertion_content_comment('oboGo_PurineSpecificnucleoside_Sodiumsymporteractivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","purine","(","out",")","+","Na","+","(","out",")","=","nucleoside","(","in",")","+","Na","+","(","in",")"),4295674). assertion_content_comment('oboGo_PutrescineBiosyntheticProcessFromArginineViaNCarbamoylputrescine',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","putrescine",",","1",",","4-diaminobutane",",","from","other","compounds",",","including","arginine",",","via","the","intermediate","N-carbamoylputrescine",";","in","this","pathway",",","arginine","is","converted","to","agmatine",",","and","agmatine","is","converted","to","putrescine","in","two","single","enzymatic","steps","."),4338506). assertion_content_comment('oboGo_PutrescineImportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","putrescine","(","out",")","=","ADP","+","phosphate","+","putrescine","(","in",")"),4293622). assertion_content_comment('oboGo_PutrescineNHydroxycinnamoyltransferaseactivity',s("Catalysis","of","the","reaction",":","caffeoyl-CoA","+","putrescine","=","N-caffeoylputrescine","+","CoA","+","H","(","+",")"),4366400). assertion_content_comment('oboGo_PutrescineNMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","putrescine","=","N-methylputrescine","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4308816). assertion_content_comment('oboGo_Pwp2pContainingsubcomplexof90spreribosome',s("A","protein","complex","that","forms","a","subcomplex","of","the","90S","preribosome","and","can","interact","directly","with","the","5","'","External","Transcribed","Spacer","(","ETS",")","of","the","full","length","pre-rRNA","transcript",".","In","S",".","cerevisiae",",","it","sediments","at","25-30","S","and","is","composed","of","Pwp2p",",","Dip2p",",","Utp21p",",","Utp13p",",","Utp18p",",","and","Utp6p","."),4075054). assertion_content_comment('oboGo_PXylenebiosyntheticprocess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","p-xylene","(","1",",","4-dimethylbenzene",")",",","a","colorless",",","liquid","aromatic","hydrocarbon","."),4353445). assertion_content_comment('oboGo_PXylenecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","p-xylene","(","1",",","4-dimethylbenzene",")",",","a","colorless",",","liquid","aromatic","hydrocarbon","."),4313692). assertion_content_comment('oboGo_PXylenemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","p-xylene",",","(","1",",","4-dimethylbenzene",")","a","colorless",",","liquid","aromatic","hydrocarbon","."),4272815). assertion_content_comment('oboGo_Pyrene12Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","pyrene","+","O2","+","2","H","+","+","2","e-","=","pyrene-1",",","2-oxide","+","H2O","."),4350268). assertion_content_comment('oboGo_Pyrene_45_EpoxideHydrolaseActivity',s("Catalysis","of","the","reaction",":","pyrene-4",",","5-oxide","+","H2O","=","trans-4",",","5-dihydroxy-4",",","5-dihydropyrene","."),4350277). assertion_content_comment('oboGo_Pyrene45Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","pyrene","+","O2","+","2","H","+","+","2","e-","=","pyrene-4",",","5-oxide","+","H2O","."),4350286). assertion_content_comment('oboGo_Pyridine_34_DiolDioxygenaseActivity',s("Catalysis","of","the","reaction",":","pryidine-3",",","4-diol","+","O2","=","3-","(","N-formyl",")","-formiminopyruvate","."),4351196). assertion_content_comment('oboGo_PyridineContainingcompoundbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pyridine-containing","compound",",","i.e",".","any","compound","that","contains","pyridine","or","a","formal","derivative","thereof","."),4157192). assertion_content_comment('oboGo_PyridineContainingcompoundcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","pyridine-containing","compound",",","i.e",".","any","compound","that","contains","pyridine","or","a","formal","derivative","thereof","."),4157208). assertion_content_comment('oboGo_PyridineContainingcompoundmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","a","pyridine-containing","compound",",","i.e",".","any","compound","that","contains","pyridine","or","a","formal","derivative","thereof","."),4021153). assertion_content_comment('oboGo_PyridineNMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","+","pyridine","=","N-methylpyridinium","+","S-adenosyl-L-homocysteine","."),4308658). assertion_content_comment('oboGo_Pyridoxal4Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NAD","(","+",")","+","pyridoxal","=","4-pyridoxolactone","+","H","(","+",")","+","NADH","."),4263540). assertion_content_comment('oboGo_Pyridoxal5Phosphatesalvage',s("Any","process","that","generates","pyridoxal","5","'","-phosphate",",","the","active","form","of","vitamin","B6",",","from","derivatives","of","it","without","de","novo","synthesis","."),4258778). assertion_content_comment('oboGo_PyridoxamineOxaloacetatetransaminaseactivity',s("Catalysis","of","the","reaction",":","oxaloacetate","+","pyridoxamine","=","L-aspartate","+","pyridoxal","."),4237649). assertion_content_comment('oboGo_PyridoxaminePhosphateoxidaseactivity',s("Catalysis","of","the","reaction",":","pyridoxamine","5","'","-phosphate","+","H2O","+","O2","=","pyridoxal","5","'","-phosphate","+","NH3","+","hydrogen","peroxide","."),4200844). assertion_content_comment('oboGo_PyridoxaminePhosphatetransaminaseactivity',s("Catalysis","of","the","reaction",":","pyridoxamine","5","'","-phosphate","+","2-oxoglutarate","=","pyridoxal","5","'","-phosphate","+","D-glutamate","."),4237635). assertion_content_comment('oboGo_PyridoxaminePyruvatetransaminaseactivity',s("Catalysis","of","the","reaction",":","pyridoxamine","+","pyruvate","=","L-alanine","+","pyridoxal","."),4369210). assertion_content_comment('oboGo_Pyridoxine4Oxidaseactivity',s("Catalysis","of","the","reaction",":","pyridoxine","+","O2","=","pyridoxal","+","H2O2","."),4263566). assertion_content_comment('oboGo_Pyridoxine5Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","pyridoxine","+","acceptor","=","isopyridoxal","+","reduced","acceptor","."),4263551). assertion_content_comment('oboGo_Pyridoxine5OBetaDGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","pyridoxine","+","UDP-D-glucose","=","5","'","-O-beta-D-glucosylpyridoxine","+","H","(","+",")","+","UDP","."),4366994). assertion_content_comment('oboGo_Pyridoxine5Phosphatesynthaseactivity',s("Catalysis","of","the","reaction",":","1-deoxy-D-xylulose","5-phosphate","+","3-amino-2-oxopropyl","phosphate","=","2","H","(","2",")","O","+","H","(","+",")","+","phosphate","+","pyridoxine","5","'","-phosphate","."),4343771). assertion_content_comment('oboGo_Pyridoxine_NADP4Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","pyridoxine","=","H","(","+",")","+","NADPH","+","pyridoxal","."),4263525). assertion_content_comment('oboGo_Pyrimidine_5_NucleotideNucleosidaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","a","pyrimidine","5","'","-nucleotide","=","ribose-5-phosphate","+","a","pyrimidine","."),4370420). assertion_content_comment('oboGo_PyrimidineAndadenineSpecific_Sodiumsymporteractivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","(","pyrimidine","nucleoside","or","adenine",")","(","out",")","+","Na","+","(","out",")","=","(","pyrimidine","nucleoside","or","adenine",")","(","in",")","+","Na","+","(","in",")"),4295813). assertion_content_comment('oboGo_PyrimidineContainingcompoundbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","pyrimidine-containing","compound",",","i.e",".","any","compound","that","contains","pyrimidine","or","a","formal","derivative","thereof","."),4157176). assertion_content_comment('oboGo_PyrimidineContainingcompoundcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","pyrimidine-containing","compound",",","i.e",".","any","compound","that","contains","pyrimidine","or","a","formal","derivative","thereof","."),4157161). assertion_content_comment('oboGo_PyrimidineContainingcompoundmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","a","pyrimidine-containing","compound",",","i.e",".","any","compound","that","contains","pyrimidine","or","a","formal","derivative","thereof","."),4010795). assertion_content_comment('oboGo_PyrimidineContainingcompoundsalvage',s("Any","process","that","generates","a","pyrimidine-containing","compound",",","any","nucleobase",",","nucleoside",",","nucleotide","or","nucleic","acid","that","contains","a","pyrimidine","base",",","from","derivatives","of","them","without","de","novo","synthesis","."),4225832). assertion_content_comment('oboGo_PyrimidineContainingcompoundtransmembranetransport',s("The","directed","movement","of","a","pyrimidine-containing","compound","across","a","membrane",".","A","pyrimidine-containing","compound","is","any","compound","that","contains","pyrimidine","or","a","formal","derivative","thereof","."),4053816). assertion_content_comment('oboGo_PyrimidineDeoxynucleoside1Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2","'","-deoxyuridine","+","2-oxoglutarate","+","O","(","2",")","=","2-deoxy-D-ribono-1",",","4-lactone","+","CO","(","2",")","+","succinate","+","uracil","."),4365069). assertion_content_comment('oboGo_PyrimidineDeoxynucleoside2Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","2","'","-deoxyuridine","+","2-oxoglutarate","+","O","(","2",")","=","CO","(","2",")","+","succinate","+","uridine","."),4364927). assertion_content_comment('oboGo_PyrimidineDimerDNANGlycosylaseactivity',s("Catalysis","of","the","removal","of","pyrimidine","dimers","by","removing","the","5","'","pyrimidine","of","the","dimer","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","5","'","pyrimidine","of","the","dimer","and","the","deoxyribose","sugar",".","The","reaction","releases","the","5","'","pyrimidine","of","the","dimer","and","leaves","an","apurinic","(","AP",")","site",".","The","reaction","involves","the","formation","of","a","covalent","enzyme","substrate","intermediate",".","Release","of","the","enzyme","and","free","base","by","a","beta-elimination","or","a","beta",",","gamma-elimination","mechanism","results","in","the","cleavage","of","the","DNA","backbone","3","'","of","the","apyrimidinic","(","AP",")","site","."),4363777). assertion_content_comment('oboGo_PyrimidineDimerRepairByNucleotideExcisionrepair',s("The","repair","of","UV-induced","T-T",",","C-T",",","and","C-C","dimers","by","the","recognition","and","removal","of","the","damaged","DNA","strand","from","the","DNA","helix","as","an","oligonucleotide",".","The","small","gap","left","in","the","DNA","helix","is","filled","in","by","the","sequential","action","of","DNA","polymerase","and","DNA","ligase","."),4363809). assertion_content_comment('oboGo_PyrimidineDimerrepairdnadamageexcision',s("OBSOLETE",".","The","excision","of","damaged","DNA","during","pyrimidine-dimer","repair",".","A","large","multienzyme","complex","scans","the","DNA","for","a","distortion","in","the","double","helix","rather","than","for","a","specific","base","change",".","Once","a","bulky","lesion","is","found",",","the","phosphodiester","backbone","of","the","abnormal","strand","is","cleaved","on","both","sides","of","the","distortion",",","and","the","portion","of","the","strand","containing","the","lesion","(","an","oligonucleotide",")","is","peeled","away","from","the","DNA","double","helix","by","a","DNA","helicase","enzyme","."),4223812). assertion_content_comment('oboGo_PyrimidineDimerrepairdnadamagerecognition',s("OBSOLETE",".","The","location","of","pyrimidine","dimers","by","a","large","multienzyme","complex","that","scans","the","DNA","for","distortions","in","the","double","helix","caused","by","pyrimidine","dimers","."),4223824). assertion_content_comment('oboGo_PyrimidineNucleosidephosphorylaseactivity',s("Catalysis","of","the","reaction",":","pyrimidine","nucleoside","+","phosphate","=","pyrimidine","+","alpha-D-ribose","1-phosphate","."),4303209). assertion_content_comment('oboGo_PyrimidineNucleotideSugartransport',s("The","directed","movement","of","pyrimidine","nucleotide-sugars","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Pyrimidine","nucleotide-sugars","are","pyrimidine","nucleotides","in","glycosidic","linkage","with","a","monosaccharide","or","monosaccharide","derivative","."),4158272). assertion_content_comment('oboGo_PyrimidinergicNucleotideReceptorActivityGProteincoupled',s("Combining","with","a","pyrimidine","nucleotide","and","transmitting","the","signal","to","a","heterotrimeric","G-protein","complex","to","initiate","a","change","in","cell","activity","."),4171653). assertion_content_comment('oboGo_PyrimidineSpecificmismatchbasepairdnanGlycosylaseactivity',s("Catalysis","of","the","removal","of","mismatched","pyrimidine","bases","in","DNA",".","Enzymes","with","this","activity","recognize","and","remove","pyrimidines","present","in","mismatches","by","cleaving","the","N-C1","'","glycosidic","bond","between","the","target","damaged","DNA","base","and","the","deoxyribose","sugar",".","The","reaction","releases","a","free","base","and","leaves","an","apyrimidinic","(","AP",")","site","."),4256146). assertion_content_comment('oboGo_Pyrogallol12Oxygenaseactivity',s("Catalysis","of","the","reaction",":","O","(","2",")","+","pyrogallol","=","(","Z",")","-5-oxohex-2-enedioate","+","2","H","(","+",")"),4263589). assertion_content_comment('oboGo_PyroglutamylPeptidaseactivity',s("Catalysis","of","the","release","of","the","N-terminal","pyroglutamyl","group","from","a","peptide","or","protein","."),4209210). assertion_content_comment('oboGo_PyroglutamylPeptidaseiactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","pyroglutamyl-peptide","+","H2O","=","pyroglutamate","+","peptide","."),4209213). assertion_content_comment('oboGo_PyroglutamylPeptidaseiiactivity',s("OBSOLETE",".","Catalysis","of","the","release","of","the","N-terminal","pyroglutamyl","group","from","pGlu-His-Xaa","tripeptides","and","pGlu-His-Xaa-Gly","tetrapeptides","."),4302080). assertion_content_comment('oboGo_PyrophosphateDependentphosphofructokinasecomplexalphaSubunitcomplex',s("Refers","to","the","alpha","subunit","of","the","heterodimeric","complex","that","possesses","pyrophosphate-dependent","phosphofructokinase","activity","."),4030670). assertion_content_comment('oboGo_PyrophosphateDependentphosphofructokinasecomplexbetaSubunitcomplex',s("Refers","to","the","beta","subunit","of","the","heterodimeric","complex","that","possesses","pyrophosphate-dependent","phosphofructokinase","activity","."),4030659). assertion_content_comment('oboGo_PyrophosphateDependentphosphofructokinasecomplex',s("Heterodimeric","complex","that","catalyzes","the","pyrophosphate-dependent","phosphorylation","of","D-fructose","6-phosphate","into","D-fructose","1",",","6-bisphosphate","."),4030648). assertion_content_comment('oboGo_Pyrrole_2_CarboxylateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","pryrole-2-carboxylate","+","H","+","=","pyrrole","+","CO2","."),4348814). assertion_content_comment('oboGo_Pyrrole_2_CarboxylateMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","pryrole-2-carboxylate","+","NADH","+","O2","+","H","+","=","5-hydroxypyrrole-2-carboxylate","+","NAD","+","+","H2O","."),4348851). assertion_content_comment('oboGo_Pyrroline_2_CarboxylateReductaseActivity',s("Catalysis","of","the","reaction",":","L-proline","+","NAD","(","P",")","+","=","1-pyrroline-2-carboxylate","+","NAD","(","P",")","H","+","H","+"),4263600). assertion_content_comment('oboGo_Pyrroline_5_CarboxylateReductaseActivity',s("Catalysis","of","the","reaction",":","L-proline","+","NADP","+","=","1-pyrroline-5-carboxylate","+","NADPH","+","H","+"),4200807). assertion_content_comment('oboGo_PyrroloquinolineQuinonesynthaseactivity',s("Catalysis","of","the","reaction",":","6-","(","2-amino-2-carboxyethyl",")","-7",",","8-dioxo-1",",","2",",","3",",","4",",","7",",","8-hexahydroquinoline-2",",","4-dicarboxylate","+","3","O","(","2",")","=","2","H","(","2",")","O","+","2","H","(","2",")","O","(","2",")","+","H","(","+",")","+","pyrroloquinoline","quinone","."),4342589). assertion_content_comment('oboGo_PyrrolysylTrnasynthetaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","L-pyrrolysine","+","tRNA","(","Pyl",")","=","AMP","+","diphosphate","+","L-pyrrolysyl-tRNA","(","Pyl",")"),4327905). assertion_content_comment('oboGo_PyruvateDehydrogenaseAcetylTransferringactivity',s("Catalysis","of","the","reaction",":","pyruvate","+","lipoamide","=","S-acetyldihydrolipoamide","+","CO2","."),4201112). assertion_content_comment('oboGo_PyruvateDehydrogenaseAcetylTransferringkinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","pyruvate","dehydrogenase","(","acetyl-transferring",")","=","ADP","+","pyruvate","dehydrogenase","(","acetyl-transferring",")","phosphate","."),4201214). assertion_content_comment('oboGo_PyruvateDehydrogenaseNADPActivity_7',s("Catalysis","of","the","reaction",":","pyruvate","+","CoA","+","NAD","(","P",")","+","=","acetyl-CoA","+","CO2","+","NAD","(","P",")","H","."),4353938). assertion_content_comment('oboGo_PyruvateFlavodoxinoxidoreductaseactivity',s("Catalysis","of","the","reaction",":","pyruvate","+","CoA","+","oxidized","flavodoxin","=","acetyl-CoA","+","CO2","+","reduced","flavodoxin","."),4326577). assertion_content_comment('oboGo_PyruvateKinasePhosphataseactivity',s("Catalysis","of","the","reaction",":","[","pyruvate","kinase","]","phosphate","+","H2O","=","[","pyruvate","kinase","]","+","phosphate","."),4267362). assertion_content_comment('oboGo_PyruvateOxidaseCoAAcetylatingactivity',s("Catalysis","of","the","reaction",":","CoA","+","H","(","+",")","+","O","(","2",")","+","pyruvate","=","acetyl-CoA","+","CO","(","2",")","+","H","(","2",")","O","(","2",")"),4263679). assertion_content_comment('oboGo_QuaternaryAmmoniumCompoundTransportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","quaternary","amine","(","out",")","=","ADP","+","phosphate","+","quaternary","amine","(","in",")"),4291533). assertion_content_comment('oboGo_Quercetin23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","O","(","2",")","+","quercetin","=","2-","(","3",",","4-dihydroxybenzoyloxy",")","-4",",","6-dihydroxybenzoate","+","CO","."),4246636). assertion_content_comment('oboGo_Quercetin_33_Bissulfate7_SulfotransferaseActivity',s("Catalysis","of","the","reaction",":","quercetin","3",",","3","'","-bissulfate","+","3","'","-phosphoadenosine","5","'","-phosphosulfate","=","quercetin","3",",","3","'",",","7-trissulfate","+","adenosine","3","'",",","5","'","-bisphosphate","."),4367936). assertion_content_comment('oboGo_Quercetin3_O_GlucosyltransferaseActivity_7',s("Catalysis","of","the","transfer","of","a","glucosyl","group","from","UDP-glucose","to","the","3","'","-hydroxy","group","of","a","quercetin","molecule","."),4182022). assertion_content_comment('oboGo_Quercetin3OGlucosyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","glucosyl","group","from","UDP-glucose","to","the","3-hydroxy","group","of","a","quercetin","molecule","."),4182004). assertion_content_comment('oboGo_Quercetin3OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","3",",","5",",","7",",","3","'",",","4","'","-pentahydroxyflavone","=","S-adenosyl-L-homocysteine","+","3-methoxy-5",",","7",",","3","'",",","4","'","-tetrahydroxy-flavone","."),4308580). assertion_content_comment('oboGo_Quercetin_3_Sulfate3_SulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phospho-5","'","-adenylyl","sulfate","+","quercetin","3-sulfate","=","adenosine","3","'",",","5","'","-diphosphate","+","H","(","+",")","+","quercetin","3",",","3","'","-disulfate","."),4367909). assertion_content_comment('oboGo_Quercetin_3_Sulfate4_SulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phospho-5","'","-adenylyl","sulfate","+","quercetin","3-sulfate","=","adenosine","3","'",",","5","'","-diphosphate","+","H","(","+",")","+","quercetin","3",",","4","'","-disulfate","."),4367896). assertion_content_comment('oboGo_Quercetin4OGlucosyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","glucosyl","group","from","UDP-glucose","to","the","4","'","-hydroxy","group","of","a","quercetin","molecule","."),4182031). assertion_content_comment('oboGo_Quercetin7OGlucosyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","glucosyl","group","from","UDP-glucose","to","the","7-hydroxy","group","of","a","quercetin","molecule","."),4182013). assertion_content_comment('oboGo_QuercetinOGlucosidebiosyntheticprocess',s("The","chemical","reactions","and","pathways","leading","to","the","formation","of","O-glucosylated","derivatives","of","quercetin","."),4338894). assertion_content_comment('oboGo_QuercetinOGlucosidemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","O-glucosylated","derivatives","of","quercetin","."),4338891). assertion_content_comment('oboGo_QueuineTRNARibosyltransferaseactivity',s("Catalysis","of","the","reaction",":","tRNA","guanine","+","queuine","=","tRNA","queuine","+","guanine","."),4254233). assertion_content_comment('oboGo_Quinaldate4Oxidoreductaseactivity',s("Catalysis","of","the","reaction",":","A","+","H","(","2",")","O","+","quinaldate","=","AH","(","2",")","+","kynurenate","."),4365722). assertion_content_comment('oboGo_Quinate5Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","quinate","+","NAD","+","=","5-dehydroquinate","+","NADH","+","H","+"),4312025). assertion_content_comment('oboGo_QuinateDehydrogenasePyrroloquinolineQuinoneactivity',s("Catalysis","of","the","reaction",":","quinate","+","pyrroloquinoline-quinone","=","5-dehydroquinate","+","reduced","pyrroloquinoline-quinone","."),4371433). assertion_content_comment('oboGo_QuinateOHydroxycinnamoyltransferaseactivity',s("Catalysis","of","the","reaction",":","feruloyl-CoA","+","quinate","=","O-feruloylquinate","+","CoA","."),4367822). assertion_content_comment('oboGo_Quinine3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADPH","+","O","(","2",")","+","quinine","=","3-hydroxyquinine","+","H","(","2",")","O","+","NADP","(","+",")"),4268022). assertion_content_comment('oboGo_Quinoline2Oxidoreductaseactivity',s("Catalysis","of","the","reaction",":","quinoline","+","acceptor","+","H2O","=","isoquinolin-1","(","2H",")","-one","+","reduced","acceptor","."),4278404). assertion_content_comment('oboGo_Quinoline_4_Carboxylate2_OxidoreductaseActivity',s("Catalysis","of","the","reaction",":","A","+","H","(","2",")","O","+","quinoline-4-carboxylate","=","2-oxo-1",",","2-dihydroquinoline-4-carboxylate","+","AH","(","2",")"),4365790). assertion_content_comment('oboGo_R___1234_TetrahydronaphtholDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-1",",","2",",","3",",","4-tetrahydronaphthol","=","1",",","2",",","3",",","4-tetrahydronaphthalone","+","2","H","+","+","2","e-","."),4350620). assertion_content_comment('oboGo_R_2_HaloacidDehalogenaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-2-haloacid","+","H2O","=","(","S",")","-2-hydroxyacid","+","halide","."),4344982). assertion_content_comment('oboGo_R_2_HydroxyacidDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-sulfolactate","+","NAD","(","P",")","+","=","3-sulfopyruvate","+","NAD","(","P",")","H","+","H","+"),4267908). assertion_content_comment('oboGo_R_2_Hydroxy_FattyAcidDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-2-hydroxystearate","+","NAD","(","+",")","=","2-oxostearate","+","H","(","+",")","+","NADH","."),4364290). assertion_content_comment('oboGo_R_2_HydroxyglutarateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-2-hydroxyglutarate","+","acceptor","=","2-oxoglutarate","+","reduced","acceptor","."),4183488). assertion_content_comment('oboGo_R_2_HydroxyisocaproateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","2-oxoisocaproate","+","NADH","+","H","+","=","(","R",")","-2-hydroxyisocaproate","+","NAD","+"),4326293). assertion_content_comment('oboGo_R_2_MethylmalateDehydrataseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-citramalate","=","2-methylmaleate","+","H","(","2",")","O","."),4371587). assertion_content_comment('oboGo_R_3_Amino_2_Methylpropionate_PyruvateTransaminaseActivity',s("Catalysis","of","the","reaction",":","(","2R",")","-3-amino-2-methylpropanoate","+","pyruvate","=","2-methyl-3-oxopropanoate","+","L-alanine","."),4369115). assertion_content_comment('oboGo_R_3_Hydroxyacid_EsterDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","ethyl","(","R",")","-3-hydroxyhexanoate","+","NADP","(","+",")","=","ethyl","3-oxohexanoate","+","H","(","+",")","+","NADPH","."),4366062). assertion_content_comment('oboGo_R_4_HydroxymandelateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","(","R",")","-4-hydroxymandelate",",","the","anion","of","(","R",")","-4-hydroxymandelic","acid","."),4243334). assertion_content_comment('oboGo_R_4_HydroxymandelateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","(","R",")","-4-hydroxymandelate",",","the","anion","of","a","hydroxylated","derivative","of","mandelate","(","alpha-hydroxybenzeneacetate",")"),4243331). assertion_content_comment('oboGo_R_4_HydroxyphenyllactateDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","+","+","(","R",")","-3-","(","4-hydroxyphenyl",")","lactate","=","NAD","(","P",")","H","+","H","+","+","3-","(","4-hydroxyphenyl",")","pyruvate","."),4364012). assertion_content_comment('oboGo_R_6_HydroxynicotineOxidaseActivity',s("Catalysis","of","the","reaction",":","(","R",")","-6-hydroxynicotine","+","H","(","2",")","O","+","O","(","2",")","=","6-hydroxypseudooxynicotine","+","H","(","2",")","O","(","2",")"),4278129). assertion_content_comment('oboGo_R8CellMediatedphotoreceptororganization',s("The","regionalization","process","that","coordinates","the","recruitment","and","organization","of","other","non-R8","photoreceptors","by","the","R8","photoreceptor","."),4088538). assertion_content_comment('oboGo_RabGDPDissociationinhibitoractivity',s("Prevents","the","dissociation","of","GDP","from","the","small","GTPase","Rab",",","thereby","preventing","GTP","from","binding","."),4215200). assertion_content_comment('oboGo_RabGuanylNucleotideexchangefactoractivity',s("Stimulates","the","exchange","of","guanyl","nucleotides","associated","with","a","GTPase","of","the","Rab","family",".","Under","normal","cellular","physiological","conditions",",","the","concentration","of","GTP","is","higher","than","that","of","GDP",",","favoring","the","replacement","of","GDP","by","GTP","in","association","with","the","GTPase","."),4267428). assertion_content_comment('oboGo_RabProteingeranylgeranyltransferasecomplex',s("A","heterodimeric","enzyme","complex",",","which","in","mammals","is","composed","of","an","alpha","and","a","beta","subunit",",","and","which","associates","with","an","accessory","protein","Rep","(","Rab","escort","protein",")","Catalyzes","of","the","transfer","of","a","geranyl-geranyl","group","from","geranylgeranyl","pyrophosphate","to","a","Rab","protein","."),4221070). assertion_content_comment('oboGo_RacGuanylNucleotideexchangefactoractivity',s("Stimulates","the","exchange","of","guanyl","nucleotides","associated","with","a","GTPase","of","the","Rac","family",".","Under","normal","cellular","physiological","conditions",",","the","concentration","of","GTP","is","higher","than","that","of","GDP",",","favoring","the","replacement","of","GDP","by","GTP","in","association","with","the","GTPase","."),4308271). assertion_content_comment('oboGo_Rad17RFCLikecomplex',s("A","pentameric","protein","complex","related","to","replication","factor","C",",","which","loads","a","trimeric","complex","of","checkpoint","proteins","(","known","as","the","checkpoint","clamp","or","9-1-1","complex",")","onto","DNA","at","damage","sites",";","functions","in","DNA","damage","cell","cycle","checkpoints",".","In","Schizosaccharomyces","pombe","the","subunits","are","known","as","Rad17",",","Rfc2",",","Rfc3",",","Rfc4",",","and","Rfc5",",","while","in","Saccharomyces","cerevisiae","the","subunits","are","known","as","Rad24p",",","Rfc2p",",","Rfc3p",",","Rfc4p",",","and","Rfc5p","."),4319808). assertion_content_comment('oboGo_Rad51BRad51ccomplex',s("A","DNA","recombinase","mediator","complex","that","contains","the","Rad51","paralogs","RAD51B","and","RAD51C",",","or","orthologs","thereof","."),4347326). assertion_content_comment('oboGo_Rad51BRad51cRad51dXrcc2complex',s("A","DNA","recombinase","mediator","complex","that","contains","the","Rad51","paralogs","RAD51B",",","RAD51C",",","RAD51D",",","and","XRCC2",",","or","orthologs","thereof","."),4347369). assertion_content_comment('oboGo_Rad51CXrcc3complex',s("A","DNA","recombinase","mediator","complex","that","contains","the","Rad51","paralogs","RAD51C","and","XRCC3",",","or","orthologs","thereof","."),4347336). assertion_content_comment('oboGo_RAD52Ercc4Ercc1complex',s("A","nucleotide-excision","repair","complex","formed","by","the","association","of","the","heterodimeric","endonuclease","XPF/ERCC4-ERCC1","(","Rad1p","and","Rad10p","in","S",".","cerevisiae",")","with","the","RAD52","protein","."),4172919). assertion_content_comment('oboGo_RaffinoseRaffinosealphaGalactotransferaseactivity',s("Catalysis","of","the","reaction",":","2","raffinose","=","sucrose","+","1F-alpha-D-galactosylraffinose","."),4366958). assertion_content_comment('oboGo_RalGuanylNucleotideexchangefactoractivity',s("Stimulates","the","exchange","of","guanyl","nucleotides","associated","with","a","GTPase","of","the","Ral","family",".","Under","normal","cellular","physiological","conditions",",","the","concentration","of","GTP","is","higher","than","that","of","GDP",",","favoring","the","replacement","of","GDP","by","GTP","in","association","with","the","GTPase","."),4255241). assertion_content_comment('oboGo_RAminopropanoldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-1-aminopropan-2-ol","+","NAD","(","+",")","=","aminoacetone","+","H","(","+",")","+","NADH","."),4237435). assertion_content_comment('oboGo_RANBindingprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220276). assertion_content_comment('oboGo_RanGuanylNucleotideexchangefactoractivity',s("Stimulates","the","exchange","of","guanyl","nucleotides","associated","with","a","GTPase","of","the","Ran","family",".","Under","normal","cellular","physiological","conditions",",","the","concentration","of","GTP","is","higher","than","that","of","GDP",",","favoring","the","replacement","of","GDP","by","GTP","in","association","with","the","GTPase","."),4215520). assertion_content_comment('oboGo_RapGuanylNucleotideexchangefactoractivity',s("Stimulates","the","exchange","of","guanyl","nucleotides","associated","with","a","GTPase","of","the","Rap","family",".","Under","normal","cellular","physiological","conditions",",","the","concentration","of","GTP","is","higher","than","that","of","GDP",",","favoring","the","replacement","of","GDP","by","GTP","in","association","with","the","GTPase","."),4268505). assertion_content_comment('oboGo_RasGAPFynLynYescomplex',s("A","protein","complex","that","consists","of","a","GTPase","activator","protein","(","GAP",")","for","Ras","and","three","Src","family","protein","tyrosine","kinases",",","Fyn",",","Lyn","and","Yes",".","The","complex","is","involved","in","signaling","upon","platelet","activation","."),4348457). assertion_content_comment('oboGo_RasGuanylNucleotideexchangefactoractivity',s("Stimulates","the","exchange","of","guanyl","nucleotides","associated","with","a","GTPase","of","the","Ras","superfamily",".","Under","normal","cellular","physiological","conditions",",","the","concentration","of","GTP","is","higher","than","that","of","GDP",",","favoring","the","replacement","of","GDP","by","GTP","in","association","with","the","GTPase","."),4215518). assertion_content_comment('oboGo_RaucaffricineBetaGlucosidaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","raucaffricine","=","D-glucose","+","vomilenine","."),4263645). assertion_content_comment('oboGo_RbE2fcomplex',s("A","multiprotein","complex","containing","a","heterodimeric","E2F","transcription","factor","and","a","Retinoblastoma","(","Rb",")","family","member",".","This","complex","is","capable","of","repressing","transcription","of","E2F-regulated","genes","in","order","to","regulate","cell","cycle","progression","."),4381998). assertion_content_comment('oboGo_RBenzylsuccinylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-2-benzylsuccinyl-CoA","+","2","electron-transferring","flavoprotein","=","(","E",")","-2-benzylidenesuccinyl-CoA","+","2","reduced","electron-transferring","flavoprotein","."),4342435). assertion_content_comment('oboGo_RC_1DNARecombinationComplex',s("A","protein","complex","that","contains","DNA","ligase","III",",","DNA","polymerase","epsilon",",","a","5","'","-3","'","exonuclease",",","and","the","SMC1","and","SMC2","proteins",",","and","is","involved","in","recombinational","repair","of","deletions","and","gaps","in","DNA","."),4175969). assertion_content_comment('oboGo_RCitramalatesynthaseactivity',s("Catalysis","of","the","reaction",":","pyruvate","+","acetyl-CoA","+","H2O","=","(","R",")","-citramalate","+","CoA","."),4326303). assertion_content_comment('oboGo_RCitramalylCoalyaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-citramalyl-CoA","=","pyruvate","+","acetyl-CoA","."),4288495). assertion_content_comment('oboGo_RDehydropantoatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-4-dehydropantoate","+","H","(","2",")","O","+","NAD","(","+",")","=","(","R",")","-3",",","3-dimethylmalate","+","2","H","(","+",")","+","NADH","."),4371616). assertion_content_comment('oboGo_ReceptorAssociatedproteinactivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4302425). assertion_content_comment('oboGo_ReceptorMediatedendocytosisoflowDensitylipoproteinparticleinvolvedincholesteroltransport',s("A","receptor-mediated","endocytosis","process","that","results","in","the","uptake","of","low-density","lipoprotein","by","cells","."),4148995). assertion_content_comment('oboGo_ReceptorMediatedendocytosisofvirusbyhost',s("A","receptor-mediated","endocytosis","process","in","which","a","host","cell","takes","up","a","virus","particle",";","successive","instances","of","virus","endocytosis","result","in","the","accumulation","of","virus","particles","within","the","cell","."),4045581). assertion_content_comment('oboGo_ReceptorMediatedendocytosis',s("An","endocytosis","process","in","which","cell","surface","receptors","ensure","specificity","of","transport",".","A","specific","receptor","on","the","cell","surface","binds","tightly","to","the","extracellular","macromolecule","(","the","ligand",")","that","it","recognizes",";","the","plasma-membrane","region","containing","the","receptor-ligand","complex","then","undergoes","endocytosis",",","forming","a","transport","vesicle","containing","the","receptor-ligand","complex","and","excluding","most","other","plasma-membrane","proteins",".","Receptor-mediated","endocytosis","generally","occurs","via","clathrin-coated","pits","and","vesicles","."),3989821). assertion_content_comment('oboGo_ReceptorTyrosineKinaseLikeorphanreceptorbinding',s("Interaction","with","the","receptor","tyrosine","kinase-like","orphan","receptor","(","Ror",")"),4214750). assertion_content_comment('oboGo_RecQHelicaseTopoiiicomplex',s("A","complex","containing","a","RecQ","family","helicase","and","a","topoisomerase","III","homologue",";","may","also","include","one","or","more","additional","proteins",";","conserved","from","E",".","coli","to","human","."),4319418). assertion_content_comment('oboGo_RecruitmentOf3Endprocessingfactorstornapolymeraseiiholoenzymecomplex',s("The","process","in","which","proteins","required","for","3","'","-end","transcript","processing","become","associated","with","the","RNA","polymerase","II","holoenzyme","complex","and","the","3","'","end","of","a","transcript","."),4074654). assertion_content_comment('oboGo_RecruitmentOfHelicasePrimasecomplextodnalesions',s("The","recruitment","of","the","helicase-primase","complex","to","viral","DNA","lesions","during","viral","DNA","repair","."),4099427). assertion_content_comment('oboGo_RedFarRedlightphototransduction',s("The","sequence","of","reactions","within","a","cell","required","to","convert","absorbed","photons","from","red","or","far-red","light","into","a","molecular","signal",";","the","red",",","far-red","light","range","is","defined","as","having","a","wavelength","within","the","range","660-730","nm","."),4023251). assertion_content_comment('oboGo_RedOrFarRedlightphotoreceptoractivity',s("The","function","of","absorbing","and","responding","to","electromagnetic","radiation","with","a","wavelength","of","approximately","660-730nm",".","The","response","may","involve","a","change","in","conformation","."),4262237). assertion_content_comment('oboGo_RedOrFarRedlightsignalingpathway',s("The","series","of","molecular","signals","initiated","upon","sensing","by","photoreceptor","molecules","of","red","light","or","far","red","light",".","Red","light","is","electromagnetic","radiation","of","wavelength","of","580-700nm",".","Far","red","light","is","electromagnetic","radiation","of","wavelength","700-800nm",".","An","example","of","this","response","is","seen","at","the","beginning","of","many","plant","species","developmental","stages",".","These","include","germination",",","and","the","point","when","cotyledon","expansion","is","triggered",".","In","certain","species","these","processes","take","place","in","response","to","absorption","of","red","light","by","the","pigment","molecule","phytochrome",",","but","the","signal","can","be","reversed","by","exposure","to","far","red","light",".","During","the","initial","phase","the","phytochrome","molecule","is","only","present","in","the","red","light","absorbing","form",",","but","on","absorption","of","red","light","it","changes","to","a","far","red","light","absorbing","form",",","triggering","progress","through","development",".","An","immediate","short","period","of","exposure","to","far","red","light","entirely","returns","the","pigment","to","its","initial","state","and","prevents","triggering","of","the","developmental","process",".","A","thirty","minute","break","between","red","and","subsequent","far","red","light","exposure","renders","the","red","light","effect","irreversible",",","and","development","then","occurs","regardless","of","whether","far","red","light","exposure","subsequently","occurs","."),4023236). assertion_content_comment('oboGo_RedoxActivedisulfidebondelectroncarrier',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259462). assertion_content_comment('oboGo_RedSensitiveopsin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4297138). assertion_content_comment('oboGo_ReductivePentosePhosphatecycle',s("The","fixation","of","carbon","dioxide","(","CO2",")","as","glucose","in","the","chloroplasts","of","C3","plants",";","uses","ATP","and","NADPH","formed","in","the","light","reactions","of","photosynthesis",";","carbon","dioxide","reacts","with","ribulose","1",",","5-bisphosphate","(","catalyzed","by","the","function","of","ribulose-bisphosphate","carboxylase",")","to","yield","two","molecules","of","3-phosphoglycerate",";","these","are","then","phosphorylated","by","ATP","to","1",",","3-bisphosphateglyceraldehyde","which",",","in","turn",",","is","then","reduced","by","NADPH","to","glyceraldehyde","3-phosphate",".","The","glyceraldehyde","3-phosphate","is","converted","to","fructose","5-phosphate","and","ribulose","5-phosphate","by","aldolase","and","other","enzymes",";","the","ribulose","5-phosphate","is","phosphorylated","by","ATP","to","ribulose","1",",","5-bisphosphate","."),4045013). assertion_content_comment('oboGo_ReEntryintomitoticcellcycleafterpheromonearrestsensusaccharomyces',s("OBSOLETE",".","The","resumption","of","the","Saccharomyces","mitotic","cell","division","cycle","by","pheromone-arrested","cells","that","have","not","mated","."),4360014). assertion_content_comment('oboGo_ReEntryintomitoticcellcycleafterpheromonearrest',s("The","resumption","of","the","mitotic","cell","division","cycle","by","pheromone-arrested","cells","that","have","not","mated",".","An","example","of","this","process","is","found","in","Saccharomyces","cerevisiae","."),4360011). assertion_content_comment('oboGo_ReEntryintomitoticcellcycle',s("The","resumption","of","the","mitotic","cell","division","cycle","by","cells","that","were","in","a","quiescent","or","other","non-dividing","state","."),4137278). assertion_content_comment('oboGo_RegulationOf13AlphaGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","alpha-1",",","3","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-alpha-D-glucosidic","bonds","."),4130690). assertion_content_comment('oboGo_RegulationOf13AlphaGlucanmetabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","alpha-1",",","3","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-alpha-D-glucosidic","bonds","."),4130684). assertion_content_comment('oboGo_RegulationOf13BetaDGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta-1",",","3","glucans","."),4063993). assertion_content_comment('oboGo_RegulationOf13BetaDGlucanmetabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","beta-1",",","3","glucans","."),4063960). assertion_content_comment('oboGo_RegulationOf16BetaGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta-1",",","6","glucans","."),4114310). assertion_content_comment('oboGo_RegulationOf1_Aminocyclopropane_1_CarboxylateMetabolicProcess',s("Regulation","of","the","chemical","reactions","and","pathways","involving","1-aminocyclopropane-1-carboxylate",",","the","anion","of","1-aminocyclopropane-1-carboxylic","acid",",","a","natural","product","found","in","plant","tissues",".","It","is","a","key","intermediate","in","the","biosynthesis","of","ethylene","(","ethene",")",",","a","fruit-ripening","hormone","in","plants","."),4336337). assertion_content_comment('oboGo_RegulationOf1Phosphatidylinositol4Kinaseactivity',s("Any","process","that","modulates","the","activity","of","the","enzyme","1-phosphatidylinositol","4-kinase","."),4317403). assertion_content_comment('oboGo_RegulationOf1_Phosphatidylinositol_4_Phosphate5_KinaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","catalysis","of","the","reaction",":","ATP","+","1-phosphatidyl-1D-myo-inositol","4-phosphate","=","ADP","+","1-phosphatidyl-1D-myo-inositol","4",",","5-bisphosphate","."),4155553). assertion_content_comment('oboGo_RegulationOf46Pyruvylatedgalactoseresiduebiosyntheticprocess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","4",",","6-pyruvylated","galactose","residue","biosynthetic","process",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","pyruvylated","galactose","residue","4-6-O-","[","(","R",")","(","1-carboxyethylidine",")","]","-Gal-beta-1",",","3-",".","The","galactose","residue","is","part","of","a","larger","polysaccharide","chain","."),4111742). assertion_content_comment('oboGo_RegulationOfAcetylCoabiosyntheticprocessfrompyruvate',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","acetyl-CoA","from","pyruvate","."),4030153). assertion_content_comment('oboGo_RegulationOfActinCytoskeletonOrganizationByCellCelladhesion',s("Any","cell-cell","adhesion","process","that","modulates","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","cytoskeletal","structures","comprising","actin","filaments","and","their","associated","proteins","."),4154822). assertion_content_comment('oboGo_RegulationOfActinFilamentBasedprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","any","cellular","process","that","depends","upon","or","alters","the","actin","cytoskeleton","."),4014736). assertion_content_comment('oboGo_RegulationOfActivationInducedcelldeathoftcells',s("Any","process","that","modulates","the","occurrence","or","rate","of","activation-induced","cell","death","of","T","cells","."),4137475). assertion_content_comment('oboGo_RegulationOfAcuteInflammatoryResponseToNonAntigenicstimulus',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","an","acute","inflammatory","response","to","a","non-antigenic","stimulus","."),4000567). assertion_content_comment('oboGo_RegulationOfAcylCoabiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","acyl-CoA","."),4101304). assertion_content_comment('oboGo_RegulationOfAdenylateCyclaseActivityInvolvedInGProteinsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","adenylate","cyclase","activity","that","is","an","integral","part","of","the","series","of","molecular","signals","generated","as","a","consequence","of","a","G-protein","coupled","receptor","binding","to","its","physiological","ligand",",","resulting","in","a","subsequent","change","in","the","concentration","of","cyclic","AMP","."),4027771). assertion_content_comment('oboGo_RegulationOfAdultChitinContainingcuticlepigmentation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","establishment","of","the","adult","pattern","of","pigmentation","in","the","cuticle","of","an","organism","."),4104114). assertion_content_comment('oboGo_RegulationOfAlpha_Amino_3_Hydroxy_5_Methyl_4_IsoxazolePropionateSelectiveGlutamateReceptorActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","alpha-amino-3-hydroxy-5-methyl-4-isoxazole","propionate","selective","glutamate","receptor","activity","."),4170254). assertion_content_comment('oboGo_RegulationOfAlphaBetatcellactivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","alpha-beta","T","cell","activation","."),4069577). assertion_content_comment('oboGo_RegulationOfAlphaBetatcelldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","alpha-beta","T","cell","differentiation","."),4069583). assertion_content_comment('oboGo_RegulationOfAlphaBetatcellproliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","alpha-beta","T","cell","proliferation","."),4098913). assertion_content_comment('oboGo_RegulationOfAlphaGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","relusting","in","the","formation","of","alpha-glucans","."),4063877). assertion_content_comment('oboGo_RegulationOfAlphaGlucanmetabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","alpha-glucans","."),4063873). assertion_content_comment('oboGo_RegulationOfAntiApoptosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","anti-apoptosis","."),4042090). assertion_content_comment('oboGo_RegulationOfAntibodyDependentcellularcytotoxicity',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","antibody-dependent","cellular","cytotoxicity","."),3983370). assertion_content_comment('oboGo_RegulationOfAntigenReceptorMediatedsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signaling","pathways","initiated","by","the","cross-linking","of","an","antigen","receptor","on","a","B-","or","T","cell","."),4052356). assertion_content_comment('oboGo_RegulationOfArp23ComplexMediatedactinnucleation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","actin","nucleation","mediated","by","the","Arp2/3","complex","and","interacting","proteins","."),4075109). assertion_content_comment('oboGo_RegulationOfAscosporeWall13BetaDGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","ascospore","wall","1",",","3-beta-glucan","biosynthetic","process",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","1",",","3-beta-glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-beta-D-glucosidic","bonds",",","found","in","the","walls","of","ascospores","."),4111617). assertion_content_comment('oboGo_RegulationOfAscosporeWallBetaGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","ascospore","wall","beta-glucan","biosynthetic","process",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta-glucans",",","compounds","composed","of","glucose","residues","linked","by","beta-D-glucosidic","bonds",",","found","in","the","walls","of","ascospores","."),4111600). assertion_content_comment('oboGo_RegulationOfB_1BCellDifferentiation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","B-1","B","cell","differentiation",".","B-1","B","cells","are","a","distinct","subset","of","B","cells","characterized","as","being","CD5","positive",",","found","predominantly","in","the","peritoneum",",","pleural","cavities",",","and","spleen",",","and","enriched","for","self-reactivity","."),3989124). assertion_content_comment('oboGo_RegulationOfBetaGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","relusting","in","the","formation","of","beta-glucans","."),4063931). assertion_content_comment('oboGo_RegulationOfBetaGlucanmetabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","beta-glucans","."),4063904). assertion_content_comment('oboGo_RegulationOfBetaLactamaseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","beta-lactamase","activity",",","the","hydrolysis","of","a","beta-lactam","to","yield","a","substituted","beta-amino","acid","."),4337916). assertion_content_comment('oboGo_RegulationOfBiosyntheticProcessOfAntibacterialPeptidesActiveAgainstGramNegativebacteria',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","biosynthesis","of","antibacterial","peptides","active","against","Gram-negative","bacteria","."),4000837). assertion_content_comment('oboGo_RegulationOfBiosyntheticProcessOfAntibacterialPeptidesActiveAgainstGramPositivebacteria',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","biosynthesis","of","antibacterial","peptides","active","against","Gram-positive","bacteria","."),4000878). assertion_content_comment('oboGo_RegulationOfBloodVesselSizeByReninAngiotensin',s("The","process","in","which","the","diameter","of","a","blood","vessel","is","changed","due","to","activity","of","the","renin-angiotensin","system","."),3990480). assertion_content_comment('oboGo_RegulationOfBloodVolumeByReninAngiotensin',s("The","process","in","which","the","renin-angiotensin","system","controls","the","rate","of","fluid","intake","and","output","into","the","blood","."),3991392). assertion_content_comment('oboGo_RegulationOfBrainDerivedneurotrophicfactorreceptoractivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","brain-derived","neurotrophic","factor","receptor","activity","."),4322126). assertion_content_comment('oboGo_RegulationOfBrainDerivedneurotrophicfactorreceptorsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signaling","via","the","brain-derived","neurotrophic","factor","receptor","signaling","pathway","."),4060480). assertion_content_comment('oboGo_RegulationOfBranchingInvolvedInMammaryCordMorphogenesisByFatPrecursorCellEpithelialcellsignaling',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","branching","of","the","mammary","gland","cord","as","a","result","of","a","signal","being","created","by","a","mammary","fat","precursor","cell","and","its","subsequent","reception","and","interpretation","by","a","mammary","cord","epithelial","cell","."),4111972). assertion_content_comment('oboGo_RegulationOfBranchingInvolvedInSalivaryGlandMorphogenesisByEpithelialMesenchymalsignaling',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","salivary","gland","branching","as","a","result","of","the","transfer","of","information","from","the","epithelial","cells","to","the","mesenchymal","cells","of","the","salivary","gland","."),4160949). assertion_content_comment('oboGo_RegulationOfBranchingInvolvedInSalivaryGlandMorphogenesisByExtracellularMatrixEpithelialcellsignaling',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","salivary","gland","branching","as","a","result","of","the","transfer","of","information","from","the","extracellular","matrix","to","the","epithelium","of","the","salivary","gland","."),4160938). assertion_content_comment('oboGo_RegulationOfBranchingInvolvedInSalivaryGlandMorphogenesisByMesenchymalEpithelialsignaling',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","branching","involved","in","salivary","gland","morphogenesis","as","a","result","of","signals","being","generated","by","the","mesenchyme","and","received","and","interpreted","by","the","salivary","gland","epithelium","."),4160927). assertion_content_comment('oboGo_RegulationOfCalcidiol1Monooxygenaseactivity',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","calcidiol","1-monooxygenase","activity",".","Calcidiol","1-monooxygenase","activity","is","catalysis","of","the","reaction",":","calcidiol","+","NADPH","+","H","+","+","O2","=","calcitriol","+","NADP","+","+","H2O","."),4160682). assertion_content_comment('oboGo_RegulationOfCalcineurinNfatsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signaling","via","the","calcineurin-NFAT","signaling","pathway","."),4132106). assertion_content_comment('oboGo_RegulationOfCalciumDependentcellCelladhesion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","attachment","of","one","cell","to","another","cell","via","adhesion","molecules","that","require","the","presence","of","calcium","for","the","interaction","."),4098553). assertion_content_comment('oboGo_RegulationOfCalciumIndependentcellCelladhesion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","attachment","of","one","cell","to","another","cell","via","adhesion","molecules","that","do","not","require","the","presence","of","calcium","for","the","interaction","."),4119305). assertion_content_comment('oboGo_RegulationOfCalciumIonDependentexocytosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","calcium","ion-dependent","exocytosis","."),4040913). assertion_content_comment('oboGo_RegulationOfCalciumIonTransportViaStoreOperatedcalciumchannelactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","calcium","ions","via","a","store-operated","calcium","channel","."),4329735). assertion_content_comment('oboGo_RegulationOfCalciumIonTransportViaVoltageGatedcalciumchannelactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","calcium","ions","via","a","voltage-gated","calcium","channel","."),4183001). assertion_content_comment('oboGo_RegulationOfCalciumMediatedsignaling',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","calcium-mediated","signaling",",","the","process","in","which","a","cell","uses","calcium","ions","to","convert","an","extracellular","signal","into","a","response","."),4100725). assertion_content_comment('oboGo_RegulationOfCalciumOrCalmodulinMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","its","calcium","or","calmodulin-mediated","signal","transduction","as","a","result","of","detecting","host","molecules","in",",","on","or","near","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152598). assertion_content_comment('oboGo_RegulationOfCAMPDependentproteinkinaseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cAMP-dependent","protein","kinase","activity","."),4171674). assertion_content_comment('oboGo_RegulationOfCAMPMediatedsignalinginresponsetohost',s("Any","process","in","which","the","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","its","cAMP-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152544). assertion_content_comment('oboGo_RegulationOfCAMPMediatedsignaling',s("Any","process","which","modulates","the","frequency",",","rate","or","extent","of","cAMP-mediated","signaling",",","a","series","of","molecular","signals","in","which","a","cell","uses","cyclic","AMP","to","convert","an","extracellular","signal","into","a","response","."),4096468). assertion_content_comment('oboGo_RegulationOfCD4PositivealphaBetatcellactivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CD4-positive",",","alpha-beta","T","cell","activation","."),4069598). assertion_content_comment('oboGo_RegulationOfCD4PositivealphaBetatcelldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","CD4-positive",",","alpha","beta","T","cell","differentiation","."),4069601). assertion_content_comment('oboGo_RegulationOfCD4PositivealphaBetatcellproliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CD4-positive",",","alpha-beta","T","cell","proliferation","."),4144383). assertion_content_comment('oboGo_RegulationOfCD4Positivecd25PositivealphaBetaregulatorytcelldifferentiationinvolvedinimmuneresponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","differentiation","of","CD4-positive",",","CD25-positive",",","alpha-beta","regulatory","T","cells","as","part","of","an","immune","response","."),4069760). assertion_content_comment('oboGo_RegulationOfCD4Positivecd25PositivealphaBetaregulatorytcelldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","differentiation","of","CD4-positive",",","CD25-positive",",","alpha-beta","regulatory","T","cells","."),4069632). assertion_content_comment('oboGo_RegulationOfCD8PositivealphaBetacytotoxictcellextravasation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CD8-positive",",","alpha-beta","cytotoxic","T","cell","extravasation","."),4142298). assertion_content_comment('oboGo_RegulationOfCD8PositivealphaBetatcelldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","CD8-positive",",","alpha-beta","T","cell","differentiation","."),4095845). assertion_content_comment('oboGo_RegulationOfCD8PositivealphaBetatcellextravasation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CD8-positive",",","alpha-beta","T","cell","extravasation","."),4142284). assertion_content_comment('oboGo_RegulationOfCD8PositivealphaBetatcellproliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CD8-positive",",","alpha-beta","T","cell","proliferation","."),4144230). assertion_content_comment('oboGo_RegulationOfCellAdhesionInvolvedInHeartMorphogenesisByNonCanonicalwntsignalingpathway',s("Any","process","that","decreased","the","extent","of","cell","adhesion","that","contributes","to","the","shaping","of","the","heart","."),4261581). assertion_content_comment('oboGo_RegulationOfCellCelladhesioninvolvedingastrulation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","attachment","of","a","cell","to","another","cell","affecting","gastrulation","."),4076720). assertion_content_comment('oboGo_RegulationOfCellCelladhesionmediatedbycadherin',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell-cell","adhesion","mediated","by","cadherin","."),4139105). assertion_content_comment('oboGo_RegulationOfCellCelladhesionmediatedbyintegrin',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","cell-cell","adhesion","mediated","by","integrin","."),4063703). assertion_content_comment('oboGo_RegulationOfCellCelladhesion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","attachment","of","a","cell","to","another","cell","."),4006321). assertion_content_comment('oboGo_RegulationOfCellMatrixadhesion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","attachment","of","a","cell","to","the","extracellular","matrix","."),3987973). assertion_content_comment('oboGo_RegulationOfCellProliferationInvolvedInImaginalDiscDerivedwingmorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","multiplication","or","reproduction","of","cells",",","resulting","in","the","expansion","of","a","cell","population","that","contributes","to","imaginal","disc-derived","wing","morphogenesis","."),4151960). assertion_content_comment('oboGo_RegulationOfCellSubstrateadhesion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cell-substrate","adhesion",".","Cell-substrate","adhesion","is","the","attachment","of","a","cell","to","the","underlying","substrate","via","adhesion","molecules","."),3987970). assertion_content_comment('oboGo_RegulationOfCellSubstratejunctionassembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","cell-substrate","junction","assembly",".","Cell-substrate","junction","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","junction","between","a","cell","and","its","substrate","."),4122376). assertion_content_comment('oboGo_RegulationOfCellularChaperoneMediatedproteincomplexassembly',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","cellular","chaperone-mediated","protein","complex","assembly",".","Cellular","chaperone-mediated","protein","complex","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","protein","complex",",","occurring","at","the","level","of","an","individual","cell",",","mediated","by","chaperone","molecules","that","do","not","form","part","of","the","finished","complex","."),4149783). assertion_content_comment('oboGo_RegulationOfCellWall13AlphaGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","1",",","3-alpha-glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-alpha-D-glucosidic","bonds",",","found","in","the","walls","of","cells","."),4130716). assertion_content_comment('oboGo_RegulationOfCellWall13AlphaGlucanmetabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","alpha-1",",","3","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-alpha-D-glucosidic","bonds",",","found","in","the","walls","of","cells","."),4130710). assertion_content_comment('oboGo_RegulationOfCellWall13BetaDGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","1",",","3-beta-glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-beta-D-glucosidic","bonds",",","found","in","the","walls","of","cells","."),4111613). assertion_content_comment('oboGo_RegulationOfCentrioleCentriolecohesion',s("Any","process","that","modulates","the","extent","to","which","the","two","centrioles","within","a","centrosome","remain","tightly","paired",";","may","be","mediated","by","the","assembly","and","disassembly","of","a","proteinaceous","linker","."),4061182). assertion_content_comment('oboGo_RegulationOfCGMPMediatedsignaling',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","cGMP-mediated","signaling",".","cGMP-mediated","signaling","is","a","series","of","molecular","signals","in","which","a","cell","uses","cyclic","GMP","to","convert","an","extracellular","signal","into","a","response","."),4024732). assertion_content_comment('oboGo_RegulationOfChemokineCCmotifligand1production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-C","motif",")","ligand","1","."),4130012). assertion_content_comment('oboGo_RegulationOfChemokineCCmotifligand4production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-C","motif",")","ligand","4","."),4130071). assertion_content_comment('oboGo_RegulationOfChemokineCCmotifligand5production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-C","motif",")","ligand","5","."),4129934). assertion_content_comment('oboGo_RegulationOfChemokineCCmotifligand6production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-C","motif",")","ligand","6","(","CCL6",")"),4084077). assertion_content_comment('oboGo_RegulationOfChemokineCCmotifligand6secretion',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","regulated","release","of","chemokine","(","C-C","motif",")","ligand","6","(","CCL6",")","from","a","cell","or","group","of","cells","."),4084093). assertion_content_comment('oboGo_RegulationOfChemokineCXCmotifligand1production',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chemokine","(","C-X-C","motif",")","ligand","1","production","."),4143247). assertion_content_comment('oboGo_RegulationOfChemokineCXCmotifligand2production',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chemokine","(","C-X-C","motif",")","ligand","2","production","."),4143289). assertion_content_comment('oboGo_RegulationOfChemokineCXCmotifligand9production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","chemokine","(","C-X-C","motif",")","ligand","9","."),4083221). assertion_content_comment('oboGo_RegulationOfChemokineMediatedsignalingpathway',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","series","of","molecular","events","generated","as","a","consequence","of","a","chemokine","binding","to","a","cell","surface","receptor","."),4133062). assertion_content_comment('oboGo_RegulationOfChitinBasedcuticletanning',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","chitin-based","cuticular","tanning","."),4015344). assertion_content_comment('oboGo_RegulationOfChromatinSilencingAtSilentMatingTypecassette',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","chromatin","silencing","at","silent","mating-type","cassette",".","Chromatin","silencing","at","silent","mating-type","cassette","is","the","repression","of","transcription","at","silent","mating-type","loci","by","altering","the","structure","of","chromatin","."),4136060). assertion_content_comment('oboGo_RegulationOfChronicInflammatoryResponseToNonAntigenicstimulus',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","chronic","inflammatory","response","to","a","non-antigenic","stimulus","."),4000517). assertion_content_comment('oboGo_RegulationOfCircadianSleepWakeCycleNonRemsleep',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","non-rapid","eye","movement","sleep","."),4079699). assertion_content_comment('oboGo_RegulationOfClathrinMediatedendocytosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","clathrin-mediated","endocytosis","."),4142965). assertion_content_comment('oboGo_RegulationOfCorticotropinReleasinghormonesecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","corticotropin-releasing","hormone","secretion","."),4095782). assertion_content_comment('oboGo_RegulationOfCyclicNucleotidephosphodiesteraseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cyclic","nucleotide","phosphodiesterase","activity",",","the","catalysis","of","the","reaction",":","nucleotide","3","'",",","5","'","-cyclic","phosphate","+","H2O","=","nucleotide","5","'","-phosphate","."),4285973). assertion_content_comment('oboGo_RegulationOfCyclinDependentproteinkinaseactivityinvolvedbyg1s',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CDK","activity","contributing","to","the","G1/S","transition","of","the","cell","cycle","."),4059721). assertion_content_comment('oboGo_RegulationOfCyclinDependentproteinkinaseactivityinvolveding2m',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CDK","activity","contributing","to","the","G2/M","transition","of","the","cell","cycle","."),4056816). assertion_content_comment('oboGo_RegulationOfCyclinDependentproteinkinaseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","CDK","activity","."),4056812). assertion_content_comment('oboGo_RegulationOfCysteineTypeendopeptidaseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cysteine-type","endopeptidase","activity","."),4170349). assertion_content_comment('oboGo_RegulationOfCytokineMediatedsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","cytokine","mediated","signaling","pathway","."),3987740). assertion_content_comment('oboGo_RegulationOfDNADependentdnareplicationinitiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","initiation","of","DNA-dependent","DNA","replication",";","the","process","in","which","DNA","becomes","competent","to","replicate",".","In","eukaryotes",",","replication","competence","is","established","in","early","G1","and","lost","during","the","ensuing","S","phase","."),4047230). assertion_content_comment('oboGo_RegulationOfDNADependentdnareplication',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","DNA-dependent","DNA","replication",",","the","process","in","which","new","strands","of","DNA","are","synthesized",",","using","parental","DNA","as","a","template","for","the","DNA-dependent","DNA","polymerases","that","synthesize","the","new","strands","."),4027820). assertion_content_comment('oboGo_RegulationOfDNATopoisomeraseATPHydrolyzingactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","DNA","topoisomerase","(","ATP-hydrolyzing",")","activity","."),4172452). assertion_content_comment('oboGo_RegulationOfDoubleStrandbreakrepairviahomologousrecombination',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","error-free","repair","of","a","double-strand","break","in","DNA","in","which","the","broken","DNA","molecule","is","repaired","using","homologous","sequences","."),4027326). assertion_content_comment('oboGo_RegulationOfDXylosecatabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","xylose","."),4095976). assertion_content_comment('oboGo_RegulationOfEndo_14_Beta_XylanaseActivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","endo-1",",","4-beta-xylanase","activity",",","the","catalysis","of","the","endohydrolysis","of","1",",","4-beta-D-xylosidic","linkages","in","xylans","."),4286708). assertion_content_comment('oboGo_RegulationOfERToGolgiVesicleMediatedtransportbygtphydrolysis',s("The","GTP","hydrolysis","process","that","modulates","the","rate",",","frequency",",","or","extent","of","ER","to","Golgi","vesicle-mediated","transport",",","the","directed","movement","of","substances","from","the","endoplasmic","reticulum","(","ER",")","to","the","Golgi",",","mediated","by","COP","II","vesicles","."),4005368). assertion_content_comment('oboGo_RegulationOfERToGolgiVesicleMediatedtransport',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","ER","to","Golgi","vesicle-mediated","transport",",","the","directed","movement","of","substances","from","the","endoplasmic","reticulum","(","ER",")","to","the","Golgi",",","mediated","by","COP","II","vesicles",".","Small","COP","II","coated","vesicles","form","from","the","ER","and","then","fuse","directly","with","the","cis-Golgi",".","Larger","structures","are","transported","along","microtubules","to","the","cis-Golgi","."),4005366). assertion_content_comment('oboGo_RegulationOfEstablishmentOfBloodBrainbarrier',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","establishment","of","the","blood-brain","barrier",",","a","selectively","permeable","structural","and","functional","barrier","that","exists","between","the","capillaries","and","the","brain","."),4151464). assertion_content_comment('oboGo_RegulationOfFastTwitchskeletalmusclefibercontraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fast-twitch","skeletal","muscle","contraction","."),4058150). assertion_content_comment('oboGo_RegulationOfFattyAcidBetaOxidation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fatty","acid","bbeta-oxidation","."),4057971). assertion_content_comment('oboGo_RegulationOfFemaleReceptivityPostMating',s("Any","process","that","modulates","the","receptiveness","of","a","female","to","male","advances","subsequent","to","mating","."),4299585). assertion_content_comment('oboGo_RegulationOfFibronectinDependentthymocytemigration',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fibronectin-dependent","thymocyte","migration","."),4142781). assertion_content_comment('oboGo_RegulationOfFollicleStimulatinghormonesecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","follicle-stimulating","hormone","."),4099696). assertion_content_comment('oboGo_RegulationOfForminNucleatedactincableassembly',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","formin-nucleated","actin","cable","assembly",".","Formin-nucleated","actin","cable","assembly","is","the","aggregation",",","arrangement","and","bonding","together","of","a","set","of","components","to","form","a","formin-nucleated","actin","cable",".","A","formin-nucleated","actin","cable","is","an","actin","filament","bundle","that","consists","of","short","filaments","organized","into","bundles","of","uniform","polarity",",","and","is","nucleated","by","formins","."),4150628). assertion_content_comment('oboGo_RegulationOfFructose16Bisphosphate1Phosphataseactivity',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","fructose","1",",","6-bisphosphate","1-phosphatase","activity",".","Fructose","1",",","6-bisphosphate","1-phosphatase","activity","is","the","catalysis","of","the","reaction",":","D-fructose","1",",","6-bisphosphate","+","H2O","=","D-fructose","6-phosphate","+","phosphate","."),4160758). assertion_content_comment('oboGo_RegulationOfFructose16Bisphosphatemetabolicprocess',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","fructose","1",",","6-bisphosphate","metabolism",".","Fructose","1",",","6-bisphosphate","metabolism","is","the","chemical","reactions","and","pathways","involving","fructose","1",",","6-bisphosphate",",","also","known","as","FBP",".","The","D","enantiomer","is","a","metabolic","intermediate","in","glycolysis","and","gluconeogenesis","."),4116420). assertion_content_comment('oboGo_RegulationOfFungalTypecellwall13AlphaGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","1",",","3-alpha-glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-alpha-D-glucosidic","bonds",",","found","in","fungal-type","cell","walls",",","including","those","of","ascospores","."),4130742). assertion_content_comment('oboGo_RegulationOfFungalTypecellwall13AlphaGlucanmetabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","alpha-1",",","3","glucans",",","compounds","composed","of","glucose","residues","linked","by","1",",","3-alpha-D-glucosidic","bonds",",","found","in","the","walls","of","ascospores","."),4130736). assertion_content_comment('oboGo_RegulationOfFungalTypecellwallbetaGlucanbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","fungal-type","cell","wall","beta-glucan","biosynthesis",",","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","beta-glucans",",","compounds","composed","of","glucose","residues","linked","by","beta-D-glucosidic","bonds",",","found","in","the","walls","of","fungal","cells","."),4111597). assertion_content_comment('oboGo_RegulationOfFungalTypecellwallbiogenesis',s("Any","process","that","modulates","the","process","in","which","a","cell","wall","is","synthesized",",","aggregates",",","and","bonds","together",".","The","fungal-type","cell","wall","contains","beta-glucan","and","may","contain","chitin","."),4065266). assertion_content_comment('oboGo_RegulationOfFungalTypecellwallorganization',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","formation",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","fungal-type","cell","wall","."),4075671). assertion_content_comment('oboGo_RegulationOfGammaAminobutyricacidsecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","regulated","release","of","gamma-aminobutyric","acid","."),4039353). assertion_content_comment('oboGo_RegulationOfGammaAminobutyricaciduptakeinvolvedintransmissionofnerveimpulse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","directed","movement","of","gamma-aminobutyric","acid","(","GABA",",","4-aminobutyrate",")","into","a","neuron","or","glial","cell","."),4120575). assertion_content_comment('oboGo_RegulationOfGammaDeltatcellactivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gamma-delta","T","cell","activation","."),4088218). assertion_content_comment('oboGo_RegulationOfGammaDeltatcelldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gamma-delta","T","cell","differentiation","."),4088224). assertion_content_comment('oboGo_RegulationOfGammaDeltatcellproliferation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","gamma-delta","T","cell","proliferation","."),4098960). 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assertion_content_comment('oboGo_RegulationOfInterleukin_4_DependentIsotypeSwitchingToIgEIsotypes',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","interleukin-4-dependent","isotype","switching","to","IgE","isotypes","."),4144292). assertion_content_comment('oboGo_RegulationOfInterleukin_4Production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","interleukin-4","production","."),4067809). assertion_content_comment('oboGo_RegulationOfInterleukin_5BiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-5","."),4089286). assertion_content_comment('oboGo_RegulationOfInterleukin_5Production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","interleukin-5","production","."),4067624). 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assertion_content_comment('oboGo_RegulationOfInterleukin_8Secretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","interleukin-8","secretion","."),4145773). assertion_content_comment('oboGo_RegulationOfInterleukin_9BiosyntheticProcess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","interleukin-9","."),4089046). assertion_content_comment('oboGo_RegulationOfInterleukin_9Production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","interleukin-9","production","."),4068424). assertion_content_comment('oboGo_RegulationOfIP_10Production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","IP-10","."),4129157). assertion_content_comment('oboGo_RegulationOfIsopentenylDiphosphateBiosyntheticProcessMevalonateIndependentpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","isopentenyl","diphosphate","produced","via","the","methylerythritol","(","MEP",")","pathway","(","mevalonate-independent",")"),4030742). assertion_content_comment('oboGo_RegulationOfJAKStatcascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","JAK-STAT","signaling","pathway","."),4027131). assertion_content_comment('oboGo_RegulationOfLArginineimport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","L-arginine","import",".","L-arginine","import","is","the","directed","movement","of","L-arginine",",","the","L-enantiomer","of","2-amino-5-guanidinopentanoic","acid",",","into","a","cell","or","organelle","."),4035106). assertion_content_comment('oboGo_RegulationOfLAscorbicacidbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","L-ascorbic","acid","biosynthetic","process","."),4138345). assertion_content_comment('oboGo_RegulationOfLGlutamatetransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","L-glutamate","transport","."),3990680). assertion_content_comment('oboGo_RegulationOfLigandDependentnuclearreceptortranscriptioncoactivatoractivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","ligand-dependent","nuclear","receptor","transcription","coactivator","activity","."),4169950). assertion_content_comment('oboGo_RegulationOfLightActivatedchannelactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","light-activated","channel","activity","."),4298170). assertion_content_comment('oboGo_RegulationOfLightActivatedvoltageGatedcalciumchannelactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","light-activated","voltage-gated","calcium","channel","activity","."),4332912). assertion_content_comment('oboGo_RegulationOfLipopolysaccharideMediatedsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signaling","in","response","to","detection","of","lipopolysaccharide","."),4056765). assertion_content_comment('oboGo_RegulationOfLongDayphotoperiodismflowering',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","long-day","photoperiodism",",","where","the","response","associated","with","the","photoperiodism","is","flowering",".","Flowering","is","defined","by","the","switch","from","the","vegetative","to","the","reproductive","phase","."),4106362). assertion_content_comment('oboGo_RegulationOfLongTermneuronalsynapticplasticity',s("A","process","that","modulates","long-term","neuronal","synaptic","plasticity",",","the","ability","of","neuronal","synapses","to","change","long-term","as","circumstances","require",".","Long-term","neuronal","synaptic","plasticity","generally","involves","increase","or","decrease","in","actual","synapse","numbers","."),4385082). assertion_content_comment('oboGo_RegulationOfLowDensitylipoproteinparticleclearance',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","low-density","lipoprotein","particle","clearance",".","Low-density","lipoprotein","particle","clearance","is","the","process","in","which","a","low-density","lipoprotein","particle","is","removed","from","the","blood","via","receptor-mediated","endocytosis","and","its","constituent","parts","degraded","."),4035887). assertion_content_comment('oboGo_RegulationOfLowDensitylipoproteinparticlereceptorbiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","low-density","lipoprotein","particle","receptors","."),4091413). assertion_content_comment('oboGo_RegulationOfLowDensitylipoproteinparticlereceptorcatabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","low-density","lipoprotein","particle","receptors","."),4070437). assertion_content_comment('oboGo_RegulationOfMacrophageInflammatoryProtein_1GammaProduction',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","macrophage","inflammatory","protein-1","gamma","."),4129973). assertion_content_comment('oboGo_RegulationOfMammaryGlandCordElongationByMammaryFatPrecursorCellEpithelialcellsignaling',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","mammary","gland","cord","elongation","as","a","result","of","a","signal","being","created","by","a","mesenchymal","cell","that","is","a","precursor","to","the","mammary","fat","and","its","subsequent","reception","and","interpretation","by","an","mammary","cord","epithelial","cell","."),4112075). assertion_content_comment('oboGo_RegulationOfMAPKinaseMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","its","MAP","kinase-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152499). assertion_content_comment('oboGo_RegulationOfMetanephricCommaShapedbodymorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","metanephric","comma-shaped","body","morphogenesis","."),4139553). assertion_content_comment('oboGo_RegulationOfMetanephricSShapedbodymorphogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","metanephric","S-shaped","body","morphogenesis","."),4139539). assertion_content_comment('oboGo_RegulationOfMethylationDependentchromatinsilencing',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","repression","of","transcription","by","methylation","of","DNA",",","leading","to","the","formation","of","heterochromatin","."),4150713). assertion_content_comment('oboGo_RegulationOfMicrotubuleBasedmovement',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","microtubule-based","movement",",","the","movement","of","organelles",",","other","microtubules","and","other","particles","along","microtubules",",","mediated","by","motor","proteins","."),4005851). assertion_content_comment('oboGo_RegulationOfMicrotubuleBasedprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","any","cellular","process","that","depends","upon","or","alters","the","microtubule","cytoskeleton","."),4005848). assertion_content_comment('oboGo_RegulationOfMinusEndDirectedmicrotubulemotoractivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","minus-end-directed","microtubule","motor","activity","."),4155729). assertion_content_comment('oboGo_RegulationOfMonocyteChemotacticProtein_1Production',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","production","of","monocyte","chemotactic","protein-1","."),4130202). assertion_content_comment('oboGo_RegulationOfMRNA3Endprocessing',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","mRNA","3","'","-end","processing",",","any","process","involved","in","forming","the","mature","3","'","end","of","an","mRNA","molecule","."),4058200). assertion_content_comment('oboGo_RegulationOfMRNAStabilityNcRNAMediated',s("Any","process",",","mediated","by","small","non-coding","RNAs",",","that","modulates","the","propensity","of","mRNA","molecules","to","degradation",".","Includes","processes","that","both","stabilize","and","destabilize","mRNAs","."),4178214). assertion_content_comment('oboGo_RegulationOfMultiOrganismprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","a","multi-organism","process",",","a","process","in","which","an","organism","has","an","effect","on","another","organism","of","the","same","or","different","species","."),3977478). assertion_content_comment('oboGo_RegulationOfMultivesicularBodySizeInvolvedInUbiquitinDependentproteincatabolism',s("Any","process","that","modulates","the","volume","of","a","multivesicular","body","as","part","of","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","covalently","tagged","with","ubiquitin","."),4335858). assertion_content_comment('oboGo_RegulationOfMyD88DependenttollLikereceptorsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","MyD88-dependent","toll-like","receptor","signaling","pathway","."),4076861). assertion_content_comment('oboGo_RegulationOfMyD88IndependenttollLikereceptorsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","MyD88-independent","toll-like","receptor","signaling","pathway","."),4076905). assertion_content_comment('oboGo_RegulationOfMyosinLightChainPhosphataseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","myosin-light-chain-phosphatase","activity","."),4379197). assertion_content_comment('oboGo_RegulationOfNeutrophilMediatedKillingOfGramNegativebacterium',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","neutrophil","mediated","killing","of","a","gram-negative","bacterium",",","the","directed","killing","of","a","gram-negative","bacterium","by","a","neutrophil","."),4131710). assertion_content_comment('oboGo_RegulationOfNeutrophilMediatedKillingOfGramPositivebacterium',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","neutrophil","mediated","killing","of","a","gram-positive","bacterium",",","the","directed","killing","of","a","gram-positive","bacterium","by","a","neutrophil","."),4131746). assertion_content_comment('oboGo_RegulationOfNFKappabimportintonucleus',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","transfer","of","NF-kappaB",",","a","transcription","factor","for","eukaryotic","RNA","polymerase","II","promoters",",","from","the","cytoplasm","into","the","nucleus",",","across","the","nuclear","membrane","."),4016314). assertion_content_comment('oboGo_RegulationOfNitricOxidesynthase2biosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","enzyme","nitric-oxide","synthase","2","."),4122027). assertion_content_comment('oboGo_RegulationOfNitricOxidesynthaseactivity',s("Any","process","that","modulates","the","activity","of","the","enzyme","nitric-oxide","synthase","."),4273064). assertion_content_comment('oboGo_RegulationOfNitricOxidesynthasebiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","enzyme","nitric-oxide","synthase","."),4122091). assertion_content_comment('oboGo_RegulationOfNMethylDAspartateselectiveglutamatereceptoractivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","N-methyl-D-aspartate","selective","glutamate","receptor","activity","."),4170244). assertion_content_comment('oboGo_RegulationOfNonCanonicalwntreceptorsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","non-canonical","Wnt","receptor","signaling","pathway","."),4019916). assertion_content_comment('oboGo_RegulationOfNonProfessionalantigenpresentingcellantigenprocessingandpresentation',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","non-professional","antigen","presenting","cell","antigen","processing","and","presentation","."),3994499). assertion_content_comment('oboGo_RegulationOfNTerminalproteinpalmitoylation',s("Any","process","that","modulates","the","rate","frequency","or","extent","of","the","covalent","attachment","of","a","palmitoyl","group","to","the","N-terminal","amino","acid","residue","of","a","protein","."),4116089). assertion_content_comment('oboGo_RegulationOfNuclearTranscribedmrnacatabolicprocessnonsenseMediateddecay',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","nuclear-transcribed","mRNA","catabolic","process",",","nonsense-mediated","decay","."),4144085). assertion_content_comment('oboGo_RegulationOfNuclearTranscribedmrnapolyatailshortening',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","poly","(","A",")","tail","shortening","of","a","nuclear-transcribed","mRNA",".","Poly","(","A",")","tail","shortening","is","the","decrease","in","length","of","the","poly","(","A",")","tail","of","an","mRNA","from","full","length","to","an","oligo","(","A",")","length","."),4115455). assertion_content_comment('oboGo_RegulationOfNucleotideBindingoligomerizationdomaincontaining1signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","nucleotide-binding","oligomerization","domain","containing","1","(","NOD1",")","pathway","."),4136495). assertion_content_comment('oboGo_RegulationOfNucleotideBindingoligomerizationdomaincontaining2signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","nucleotide-binding","oligomerization","domain","containing","2","(","NOD2",")","pathway","."),4136432). assertion_content_comment('oboGo_RegulationOfNucleotideBindingoligomerizationdomaincontainingsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","nucleotide-binding","oligomerization","domain","containing","(","NOD",")","pathway","."),4136414). assertion_content_comment('oboGo_RegulationOfOdontogenesisOfDentineContainingtooth',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","formation","and","development","of","teeth",",","the","hard",",","bony","appendages","which","are","borne","on","the","jaws",",","or","on","other","bones","in","the","walls","of","the","mouth","or","pharynx","of","most","vertebrates","."),4078541). assertion_content_comment('oboGo_RegulationOfPathwayRestrictedsmadproteinphosphorylation',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","pathway-restricted","SMAD","protein","phosphorylation",".","Pathway-restricted","SMAD","proteins","and","common-partner","SMAD","proteins","are","involved","in","the","transforming","growth","factor","beta","receptor","signaling","pathways","."),4037077). assertion_content_comment('oboGo_RegulationOfPentosePhosphateshunt',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","pentose-phosphate","shunt",",","the","process","in","which","glucose","is","oxidized",",","coupled","to","NADPH","synthesis","."),4096174). assertion_content_comment('oboGo_RegulationOfPeptidylCysteinesNitrosylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","peptidyl-cysteine","S-nitrosylation","."),4141581). assertion_content_comment('oboGo_RegulationOfPeptidylSerinephosphorylationofstatprotein',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","phosphorylation","of","a","serine","residue","of","a","STAT","(","Signal","Transducer","and","Activator","of","Transcription",")","protein","."),4065563). assertion_content_comment('oboGo_RegulationOfPeptidylSerinephosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","phosphorylation","of","peptidyl-serine","."),4065529). assertion_content_comment('oboGo_RegulationOfPeptidylThreoninephosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","peptidyl-threonine","phosphorylation",".","Peptidyl-threonine","phosphorylation","is","the","phosphorylation","of","peptidyl-threonine","to","form","peptidyl-O-phospho-L-threonine","."),4025773). assertion_content_comment('oboGo_RegulationOfPeptidylTyrosinephosphorylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","phosphorylation","of","peptidyl-tyrosine","."),4027143). assertion_content_comment('oboGo_RegulationOfPheromoneDependentsignaltransductioninvolvedinconjugationwithcellularfusion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","pheromone-dependent","signal","transduction","during","conjugation","with","cellular","fusion",",","a","signal","transduction","process","resulting","in","the","relay",",","amplification","or","dampening","of","a","signal","generated","in","response","to","pheromone","exposure","in","organisms","that","undergo","conjugation","with","cellular","fusion","."),4035549). assertion_content_comment('oboGo_RegulationOfPhosphatidylinositol3Kinaseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","phosphatidylinositol","3-kinase","activity",",","the","catalysis","of","the","transfer","of","a","phosphate","group",",","usually","from","ATP",",","to","an","inositol","lipid","at","the","3","'","position","of","the","inositol","ring","."),4325473). assertion_content_comment('oboGo_RegulationOfPhosphatidylinositol3Kinasecascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","phosphatidylinositol","3-kinase","cascade","."),4039934). assertion_content_comment('oboGo_RegulationOfPlantTypecellwallorganizationorbiogenesis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","involving","plant-type","cell","wall","organization","or","biogenesis",".","Plant-type","cell","wall","organization","or","biogenesis","is","a","process","that","results","in","the","biosynthesis","of","constituent","macromolecules",",","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","a","cellulose-","and","pectin-containing","cell","wall","."),4147726). assertion_content_comment('oboGo_RegulationOfPlantTypehypersensitiveresponse',s("Any","endogenous","process","that","modulates","the","frequency",",","rate","or","extent","of","the","plant","hypersensitive","response","."),4031175). assertion_content_comment('oboGo_RegulationOfPlasmaKallikreinKinincascade',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","plasma","kallikrein-kinin","cascade","."),3996019). assertion_content_comment('oboGo_RegulationOfPlasmaMembraneLongChainfattyacidtransport',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","plasma","membrane","long-chain","fatty","acid","transport",".","Plasma","membrane","long-chain","fatty","acid","transport","is","the","directed","movement","of","long-chain","fatty","acids","across","the","plasma","membrane","."),4024626). assertion_content_comment('oboGo_RegulationOfPlateletDerivedgrowthfactorproduction',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","the","appearance","of","any","platelet-derived","growth","factor","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4150869). assertion_content_comment('oboGo_RegulationOfPlateletDerivedgrowthfactorreceptorAlphasignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","platelet-derived","growth","factor","receptor-alpha","signaling","pathway","."),4144579). assertion_content_comment('oboGo_RegulationOfPlateletDerivedgrowthfactorreceptorBetasignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","platelet-derived","growth","factor","receptor-beta","signaling","pathway","."),4144487). assertion_content_comment('oboGo_RegulationOfPlateletDerivedgrowthfactorreceptorsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","platelet-derived","growth","factor","receptor","signaling","pathway","."),4026182). assertion_content_comment('oboGo_RegulationOfPlusEndDirectedmicrotubulemotoractivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","plus-end-directed","microtubule","motor","activity","."),4155780). assertion_content_comment('oboGo_RegulationOfPoly3Hydroxyalkanoatebiosyntheticprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","chemical","reactions","and","pathways","resulting","in","the","formation","of","poly","(","3-hydroxyalkanoates",")",",","polyesters","of","3-hydroxyacids","produced","as","intracellular","granules","by","a","large","variety","of","bacteria","."),4093342). assertion_content_comment('oboGo_RegulationOfPositiveChemotaxisToCAMPByDIF_1',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","by","the","action","of","DIF-1",".","DIF-1","is","a","chlorinated","alkylphenone","."),4156103). assertion_content_comment('oboGo_RegulationOfPositiveChemotaxisToCAMPByDIF_2',s("Any","process","that","modulates","the","rate",",","frequency",",","or","extent","of","directed","movement","of","a","motile","cell","or","organism","up","a","concentration","gradient","of","3","'",",","5","'","-cAMP","by","the","action","of","DIF-2",".","DIF-2","is","a","chlorinated","alkylphenone","."),4156074). assertion_content_comment('oboGo_RegulationOfPostEmbryonicdevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","post-embryonic","development",".","Post-embryonic","development","is","defined","as","the","process","whose","specific","outcome","is","the","progression","of","the","organism","over","time",",","from","the","completion","of","embryonic","development","to","the","mature","structure","."),4015847). assertion_content_comment('oboGo_RegulationOfPostEmbryonicrootdevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","post-embryonic","root","development","."),4138614). assertion_content_comment('oboGo_RegulationOfPostMatingoviposition',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","deposition","of","eggs",",","either","fertilized","or","not",",","upon","a","surface","or","into","a","medium",",","following","mating","."),4104630). assertion_content_comment('oboGo_RegulationOfPreMicrornaprocessing',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","pre-microRNA","processing","."),4143933). assertion_content_comment('oboGo_RegulationOfPreTubularaggregateformationbycellCellsignaling',s("Any","process","that","mediates","the","transfer","of","information","from","one","cell","to","another","that","modulates","the","rate",",","frequency",",","or","extent","of","pre-tubular","aggregate","formation",".","Pre-tubular","aggregate","formation","is","the","cell","adhesion","process","in","which","mammary","mesenchyme","cells","adhere","to","one","another","in","the","initial","stages","of","the","formation","of","the","pre-tubular","aggregate",",","the","earliest","recognizable","structure","of","the","kidney","."),4123556). assertion_content_comment('oboGo_RegulationOfProstaglandinEndoperoxidesynthaseactivity',s("Any","process","that","modulates","the","rate",",","frequency","or","prostaglandin-endoperoxide","synthase","activity",".","Prostaglandin-endoperoxide","synthase","activity","is","the","catalysis","of","the","reaction",":","arachidonate","+","donor-H2","+","2","O2","=","prostaglandin","H2","+","acceptor","+","H2O","."),4160796). assertion_content_comment('oboGo_RegulationOfProstaglandinEsynthaseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","prostaglandin-E","synthase","activity","."),4172549). assertion_content_comment('oboGo_RegulationOfProTcelldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","pro-T","cell","differentiation","."),4141447). assertion_content_comment('oboGo_RegulationOfProteasomalUbiquitinDependentproteincatabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds",",","initiated","by","the","covalent","attachment","of","ubiquitin",",","and","mediated","by","the","proteasome","."),4012130). assertion_content_comment('oboGo_RegulationOfProteinADPRibosylation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","ADP-ribosylation",".","Protein","ADP-ribosylation","is","the","transfer",",","from","NAD",",","of","ADP-ribose","to","protein","amino","acids","."),4036652). assertion_content_comment('oboGo_RegulationOfProteinKinaseMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","its","protein","kinase-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152408). assertion_content_comment('oboGo_RegulationOfProteinUbiquitinationInvolvedInUbiquitinDependentproteincatabolicprocess',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","protein","ubiquitination","involved","in","ubiquitin-dependent","protein","catabolic","process","."),4138724). assertion_content_comment('oboGo_RegulationOfProtonTransportingatpaseactivityrotationalmechanism',s("Any","process","that","modulates","the","rate","of","ATP","hydrolysis","by","an","ATPase",".","Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","H","+","(","in",")","=","ADP","+","phosphate","+","H","+","(","out",")",",","by","a","rotational","mechanism","."),4335879). assertion_content_comment('oboGo_RegulationOfPSIIAssociatedLightHarvestingcomplexiicatabolicprocess',s("Any","process","that","modulates","the","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","one","or","more","components","of","the","light-harvesting","complex","of","photosystem","II","."),4027919). assertion_content_comment('oboGo_RegulationOfReceptorMediatedendocytosis',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","receptor","mediated","endocytosis",",","the","uptake","of","external","materials","by","cells",",","utilizing","receptors","to","ensure","specificity","of","transport","."),3989853). assertion_content_comment('oboGo_RegulationOfReceptorMediatedsignaltransductioninresponsetohost',s("Any","process","in","which","the","symbiont","organism","modulates","the","frequency",",","rate","or","extent","of","its","receptor-mediated","signal","transduction","as","a","result","of","detecting","molecules","of","its","host","organism",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4152228). assertion_content_comment('oboGo_RegulationOfRedOrFarRedlightsignalingpathway',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","the","red","or","far-red","signaling","pathway",",","the","series","of","molecular","signals","initiated","upon","sensing","by","photoreceptor","molecules","of","red","light","or","far","red","light","."),4151422). assertion_content_comment('oboGo_RegulationOfReductivePentosePhosphatecycle',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","reductive","pentose-phosphate","cycle","."),4147709). assertion_content_comment('oboGo_RegulationOfResponseToInterferonGamma',s("Any","process","that","modulates","the","rate",",","frequency","or","extent","of","a","response","to","interferon-gamma",".","Response","to","interferon","gamma","is","a","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","an","interferon-gamma","stimulus","."),4114646). assertion_content_comment('oboGo_RegulationOfRetrogradeVesicleMediatedtransportgolgitoer',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","retrograde","vesicle-mediated","transport",",","Golgi","to","ER","."),4137821). assertion_content_comment('oboGo_RegulationOfRhoDependentproteinserinethreoninekinaseactivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","Rho-dependent","protein","serine/threonine","kinase","activity","."),4169078). assertion_content_comment('oboGo_RegulationOfRyanodineSensitivecalciumReleasechannelactivity',s("Any","process","that","modulates","the","activity","of","a","ryanodine-sensitive","calcium-release","channel",".","The","ryanodine-sensitive","calcium-release","channel","catalyzes","the","transmembrane","transfer","of","a","calcium","ion","by","a","channel","that","opens","when","a","ryanodine","class","ligand","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4160440). assertion_content_comment('oboGo_RegulationOfSequenceSpecificdnabindingtranscriptionfactoractivity',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","activity","of","a","transcription","factor",",","any","factor","involved","in","the","initiation","or","regulation","of","transcription","."),4013434). assertion_content_comment('oboGo_RegulationOfShortDayphotoperiodismflowering',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","short-day","photoperiodism",",","where","the","response","associated","with","the","photoperiodism","is","flowering",".","Flowering","is","defined","by","the","switch","from","the","vegetative","to","the","reproductive","phase","."),4106290). assertion_content_comment('oboGo_RegulationOfShortTermneuronalsynapticplasticity',s("A","process","that","modulates","short-term","neuronal","synaptic","plasticity",",","the","ability","of","neuronal","synapses","to","change","in","the","short-term","as","circumstances","require",".","Short-term","neuronal","synaptic","plasticity","generally","involves","increasing","or","decreasing","synaptic","sensitivity","."),4385117). assertion_content_comment('oboGo_RegulationOfSingleStrandedtelomericdnabinding',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","binding","to","single-stranded","telomeric","DNA","."),4160154). assertion_content_comment('oboGo_RegulationOfSkeletalMuscleContractionByChemoMechanicalenergyconversion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","skeletal","muscle","contraction","by","regulating","force","and","velocity","of","shortening",".","The","force","of","skeletal","muscle","contraction","is","produced","by","acto-myosin","interaction","processes","through","formation","of","cross","bridges",".","The","shortening","leads","to","reduction","of","length","of","muscle","fiber","and","sarcomeres","."),4038885). assertion_content_comment('oboGo_RegulationOfSlowTwitchskeletalmusclefibercontraction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","slow-twitch","skeletal","muscle","contraction","."),4058324). assertion_content_comment('oboGo_RegulationOfSmoothMuscleCellMatrixadhesion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","smooth","muscle","cell-matrix","adhesion","."),4138463). assertion_content_comment('oboGo_RegulationOfSodiumDependentphosphatetransport',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","sodium-dependent","phosphate","transport","."),4137930). assertion_content_comment('oboGo_RegulationOfSporeBearingorgandevelopment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","spore-bearing","organ","development",",","a","process","in","which","hyphae","grow","into","special","aggregates","called","fruiting","bodies","that","produce","new","spores","."),4059609). assertion_content_comment('oboGo_RegulationOfSREBPMediatedsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","SREBP-mediated","signaling","pathway","."),4137628). assertion_content_comment('oboGo_RegulationOfStressActivatedmapkcascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signal","transduction","mediated","by","the","stress-activated","MAPK","cascade","."),4070156). assertion_content_comment('oboGo_RegulationOfStressActivatedproteinkinasesignalingcascade',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","signaling","via","a","stress-activated","protein","kinase","signaling","cascade","."),4016610). assertion_content_comment('oboGo_RegulationOfSystemicArterialBloodPressureByCirculatoryEpinephrineNorepinephrine',s("The","process","in","which","epinephrine-norepinephrine","modulate","the","force","with","which","blood","passes","through","the","circulatory","system","."),4193594). assertion_content_comment('oboGo_RegulationOfSystemicArterialBloodPressureByCirculatoryReninAngiotensin',s("The","process","in","which","angiotensinogen","metabolites","in","the","bloodstream","modulate","the","force","with","which","blood","passes","through","the","circulatory","system",".","The","process","begins","when","renin","is","released","and","cleaves","angiotensinogen","."),3991436). assertion_content_comment('oboGo_RegulationOfSystemicArterialBloodPressureByLocalRenalReninAngiotensin',s("The","process","in","which","angiotensinogen","metabolites","in","the","kidney","modulate","the","force","with","which","blood","passes","through","the","renal","circulatory","system",".","The","process","begins","when","renin","cleaves","angiotensinogen","."),4193914). assertion_content_comment('oboGo_RegulationOfSystemicArterialBloodPressureByNorepinephrineEpinephrine',s("The","process","in","which","the","secretion","of","norepinephrine","or","epinephrine","into","the","bloodstream","modulates","the","force","with","which","blood","passes","through","the","circulatory","system","."),3991068). assertion_content_comment('oboGo_RegulationOfSystemicArterialBloodPressureByReninAngiotensin',s("The","process","in","which","renin-angiotensin","modulates","the","force","with","which","blood","passes","through","the","circulatory","system","."),3990476). assertion_content_comment('oboGo_RegulationOfSystemicArterialBloodPressureInvolvedInAcutePhaseresponse',s("Any","process","that","modulates","the","force","with","which","blood","travels","through","the","circulatory","system","that","contributes","to","the","acute","phase","response",".","The","acute","phase","response","occurs","during","the","early","phases","of","an","infection","and","is","marked","by","changes","in","the","production","of","plasma","proteins","such","as","C-reactive","protein","."),3995998). assertion_content_comment('oboGo_RegulationOfTelomereMaintenanceViaSemiConservativereplication',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","the","semi-conservative","replication","of","telomeric","DNA","."),4054131). assertion_content_comment('oboGo_RegulationOfTHelper17celldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","17","cell","differentiation","."),4139635). assertion_content_comment('oboGo_RegulationOfTHelper17cellextravasation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","17","cell","extravasation","."),4142164). assertion_content_comment('oboGo_RegulationOfTHelper17celllineagecommitment',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","17","cell","lineage","commitment","."),4143074). assertion_content_comment('oboGo_RegulationOfTHelper17typeimmuneresponse',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","17","type","immune","response","."),4139631). assertion_content_comment('oboGo_RegulationOfTHelper1cellactivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","1","cell","activation","."),4144827). assertion_content_comment('oboGo_RegulationOfTHelper1cellcytokineproduction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","1","cell","cytokine","production","."),4145065). assertion_content_comment('oboGo_RegulationOfTHelper1celldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","1","cell","differentiation","."),4086771). assertion_content_comment('oboGo_RegulationOfTHelper1typeimmuneresponse',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","a","T-helper","1","type","immune","response","."),4000718). assertion_content_comment('oboGo_RegulationOfTHelper2cellactivation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","2","cell","activation","."),4144202). assertion_content_comment('oboGo_RegulationOfTHelper2cellcytokineproduction',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","2","cell","cytokine","production","."),4144968). assertion_content_comment('oboGo_RegulationOfTHelper2celldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","2","cell","differentiation","."),4086730). assertion_content_comment('oboGo_RegulationOfTHelpercelldifferentiation',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","T-helper","cell","differentiation","."),4086709). assertion_content_comment('oboGo_RegulationOfThyroidStimulatinghormonesecretion',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","thyroid-stimulating","hormone","secretion","."),4143651). assertion_content_comment('oboGo_RegulationOfTissueKallikreinKinincascade',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","tissue","kallikrein-kinin","cascade","."),3994311). assertion_content_comment('oboGo_RegulationOfTollLikereceptor10signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","10","signaling","pathway","."),4075947). assertion_content_comment('oboGo_RegulationOfTollLikereceptor11signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","11","signaling","pathway","."),4075884). assertion_content_comment('oboGo_RegulationOfTollLikereceptor12signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","12","signaling","pathway","."),4075839). assertion_content_comment('oboGo_RegulationOfTollLikereceptor13signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","13","signaling","pathway","."),4076115). assertion_content_comment('oboGo_RegulationOfTollLikereceptor15signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","toll-like","receptor","15","signaling","pathway","."),4141932). assertion_content_comment('oboGo_RegulationOfTollLikereceptor1signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","1","signaling","pathway","."),4076960). assertion_content_comment('oboGo_RegulationOfTollLikereceptor21signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","toll-like","receptor","21","signaling","pathway","."),4142399). assertion_content_comment('oboGo_RegulationOfTollLikereceptor2signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","2","signaling","pathway","."),4076226). assertion_content_comment('oboGo_RegulationOfTollLikereceptor3signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","3","signaling","pathway","."),4076190). assertion_content_comment('oboGo_RegulationOfTollLikereceptor4signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","4","signaling","pathway","."),4076275). assertion_content_comment('oboGo_RegulationOfTollLikereceptor5signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","5","signaling","pathway","."),4076316). assertion_content_comment('oboGo_RegulationOfTollLikereceptor6signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","6","signaling","pathway","."),4076360). assertion_content_comment('oboGo_RegulationOfTollLikereceptor7signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","7","signaling","pathway","."),4076388). assertion_content_comment('oboGo_RegulationOfTollLikereceptor8signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","8","signaling","pathway","."),4076525). assertion_content_comment('oboGo_RegulationOfTollLikereceptor9signalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","9","signaling","pathway","."),4076463). assertion_content_comment('oboGo_RegulationOfTollLikereceptorsignalingpathway',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","toll-like","receptor","signaling","pathway","."),4075834). assertion_content_comment('oboGo_RegulationOfTranscriptionCouplednucleotideExcisionrepair',s("Any","process","that","modulates","the","frequency",",","rate",",","or","extent","of","the","nucleotide-excision","repair","process","that","carries","out","preferential","repair","of","DNA","lesions","on","the","actively","transcribed","strand","of","the","DNA","duplex",".","In","addition",",","the","transcription-coupled","nucleotide-excision","repair","pathway","is","required","for","the","recognition","and","repair","of","a","small","subset","of","lesions","that","are","not","recognized","by","the","global","genome","nucleotide","excision","repair","pathway","."),4151891). assertion_content_comment('oboGo_RegulationOfTranscriptionDNADependent',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","cellular","DNA-dependent","transcription","."),3971043). assertion_content_comment('oboGo_RegulationOfTranscriptionElongationDNADependent',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","transcription","elongation",",","the","extension","of","an","RNA","molecule","after","transcription","initiation","and","promoter","clearance","by","the","addition","of","ribonucleotides","catalyzed","by","a","DNA-dependent","RNA","polymerase","."),4065306). assertion_content_comment('oboGo_RegulationOfTranscriptionFromRNAPolymeraseIIPromoterInResponseToUVInduceddnadamage',s("Any","process","that","modulates","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","as","a","result","of","a","UV","damage","stimulus","."),4335829). 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assertion_content_comment('oboGo_ResponseToIntraSdnadamagecheckpointsignal',s("A","process","that","acts","directly","to","delay","or","stop","progression","through","the","cell","cycle","in","response","to","signals","generated","as","a","result","of","intra-S","DNA","damage","checkpoint","signaling",";","contributes","to","an","intra-S","DNA","damage","checkpoint","."),4128270). assertion_content_comment('oboGo_ResponseToJasmonicAcidStimulusInvolvedInJasmonicAcidAndEthyleneDependentsystemicresistance',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","jasmonic","acid","stimulus","received","in","the","context","of","the","jasmonic","acid-","and","ethylene","(","ethene",")","-dependent","process","that","confers","broad","spectrum","systemic","resistance","to","disease","in","response","to","wounding","or","a","pathogen","."),4054739). assertion_content_comment('oboGo_ResponseToLAscorbicacid',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","an","L-ascorbic","acid","(","vitamin","C",")","stimulus","."),4166126). assertion_content_comment('oboGo_ResponseToLongDayphotoperiod',s("OBSOLETE",".","A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","photoperiod",",","an","intermittent","cycle","of","light","(","day",")","and","dark","(","night",")","photoperiod","regimes",",","with","the","light","phase","being","longer","than","the","dark","."),4307542). assertion_content_comment('oboGo_ResponseToLowDensitylipoproteinparticlestimulus',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","low-density","lipoprotein","particle","stimulus","."),4109365). assertion_content_comment('oboGo_ResponseToLowFluenceBlueLightStimulusByBlueLowFluencesystem',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","the","detection","of","a","low","fluence","blue","light","stimulus","by","the","blue","low-fluence","system",".","Blue","light","is","electromagnetic","radiation","with","a","wavelength","of","between","440","and","500nm",".","The","blue","low-fluence","system","responds","to","blue","light","at","or","below","0.1","micromols/m2",".","In","certain","species","excitation","of","the","blue","low","fluence","system","induces","the","transcription","of","a","number","of","nuclear","and","plastid","coded","genes","."),4335558). assertion_content_comment('oboGo_ResponseToNonIonicosmoticstress',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","stimulus","indicating","an","increase","or","decrease","in","the","concentration","of","non-ionic","solutes","(","e.g",".","mannitol",",","sorbitol",")","in","the","environment","."),4163652). assertion_content_comment('oboGo_ResponseToPheromoneInvolvedInPheromoneInducedunidirectionalconjugation',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","pheromone","stimulus","that","contributes","to","the","process","of","pheromone-induced","unidirectional","conjugation","."),3978562). assertion_content_comment('oboGo_ResponseToPurineContainingcompound',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","purine-containing","compound","stimulus","."),4162011). assertion_content_comment('oboGo_ResponseToShortDayphotoperiod',s("OBSOLETE",".","A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","photoperiod",",","an","intermittent","cycle","of","light","(","day",")","and","dark","(","night",")","photoperiod","regimes",",","with","the","dark","phase","being","longer","than","the","light","."),4307483). assertion_content_comment('oboGo_ResponseToSMcheckpointsignal',s("A","process","that","acts","directly","to","delay","or","stop","progression","through","the","cell","cycle","in","response","to","signals","generated","as","a","result","of","S-M","checkpoint","signaling",";","contributes","to","an","S-M","checkpoint","."),4127846). assertion_content_comment('oboGo_ResponseToTrehalose_6_PhosphateStimulus',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","trehalose-6-phosphate","stimulus","."),4162553). assertion_content_comment('oboGo_ResponseToUVA',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","UV-A","radiation","stimulus",".","UV-A","radiation","(","UV-A","light",")","spans","the","wavelengths","400","to","500","nm","."),4163270). assertion_content_comment('oboGo_ResponseToUVB',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","UV-B","radiation","stimulus",".","UV-B","radiation","(","UV-B","light",")","spans","the","wavelengths","290","to","320","nm","."),4163296). assertion_content_comment('oboGo_ResponseToUVC',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","a","UV-C","radiation","stimulus",".","UV-C","radiation","(","UV-C","light",")","spans","the","wavelengths","100","to","290","nm","."),4163327). assertion_content_comment('oboGo_ResponseToXRay',s("A","change","in","state","or","activity","of","a","cell","or","an","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","X-ray","radiation",".","An","X-ray","is","a","form","of","electromagnetic","radiation","with","a","wavelength","in","the","range","of","10","nanometers","to","100","picometers","(","corresponding","to","frequencies","in","the","range","30","PHz","to","3","EHz",")"),4163487). assertion_content_comment('oboGo_RetinaDevelopmentInCameraTypeeye',s("The","process","whose","specific","outcome","is","the","progression","of","the","retina","over","time",",","from","its","formation","to","the","mature","structure",".","The","retina","is","the","innermost","layer","or","coating","at","the","back","of","the","eyeball",",","which","is","sensitive","to","light","and","in","which","the","optic","nerve","terminates","."),4004639). assertion_content_comment('oboGo_RetinaMorphogenesisInCameraTypeeye',s("The","process","in","which","the","anatomical","structure","of","the","retina","is","generated","and","organized","."),4033540). assertion_content_comment('oboGo_RetinaVasculatureDevelopmentInCameraTypeeye',s("The","process","whose","specific","outcome","is","the","progression","of","the","vasculature","of","the","retina","over","time",",","from","its","formation","to","the","mature","structure","."),4134765). assertion_content_comment('oboGo_RetinaVasculatureMorphogenesisInCameraTypeeye',s("The","process","in","which","the","vasculature","of","the","retina","is","generated","and","organized","."),4134799). assertion_content_comment('oboGo_RetinoicAcid4Hydroxylaseactivity',s("Catalysis","of","the","conversion","of","retinoic","acid","to","4-hydroxy-retinoic","acid","."),4255773). assertion_content_comment('oboGo_RetinoicAcidMetabolicProcessInSpinalCordAnteriorPosteriorpatterning',s("The","chemical","reactions","and","pathways","involving","the","synthesis","and","degradation","of","retionic","acid","that","results","in","the","spatial","identity","of","regions","along","the","anterior-posterior","axis","of","the","spinal","cord","."),4048515). assertion_content_comment('oboGo_RetinoicAcidResponsiveelementbinding',s("Interacting","selectively","with","a","retinoic","acid-responsive","element",",","a","variable","direct","repeat","of","the","sequence","PuGGTCA","spaced","by","five","nucleotides","(","DR5",")","found","in","the","promoters","of","retinoic","acid-responsive","genes",",","to","which","retinoic","acid","receptors","bind","."),4287831). assertion_content_comment('oboGo_RetinoidXreceptoractivity',s("Combining","with","9-cis","retinoic","acid","to","initiate","a","change","in","cell","activity","."),4200052). assertion_content_comment('oboGo_RetinolOFattyAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","retinol","=","CoA","+","retinyl","ester","."),4263785). assertion_content_comment('oboGo_RetinylPalmitateesteraseactivity',s("Catalysis","of","the","reaction",":","retinyl","palmitate","+","H2O","=","retinol","+","palmitate","."),4263741). assertion_content_comment('oboGo_RetrogradeVesicleMediatedtransportgolgitoer',s("The","directed","movement","of","substances","from","the","Golgi","back","to","the","endoplasmic","reticulum",",","mediated","by","vesicles","bearing","specific","protein","coats","such","as","COPI","or","COG","."),4025397). assertion_content_comment('oboGo_ReverseTranscriptionInvolvedInRNAMediatedtransposition',s("The","synthesis","of","DNA","from","an","RNA","transposon","intermediate","."),4055074). assertion_content_comment('oboGo_RGS6Dnmt1Dmap1complex',s("A","protein","complex","formed","by","the","association","of","RGS6",",","a","negative","regulator","of","heterotrimeric","G","protein","signaling",",","with","the","DMAP1-Dnmt1","transcriptional","repressor","complex",";","in","the","complex",",","RGS6","inhibits","the","transcriptional","repressor","activity","of","DMAP1","."),4172909). assertion_content_comment('oboGo_RhamnoseTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","rhamnose","(","out/in",")","=","ADP","+","phosphate","+","rhamnose","(","in/out",")"),4338297). assertion_content_comment('oboGo_Rhamnulose_1_PhosphateAldolaseActivity',s("Catalysis","of","the","reaction",":","L-rhamnulose","1-phosphate","=","glycerone","phosphate","+","(","S",")","-lactaldehyde","."),4248244). assertion_content_comment('oboGo_RhoDependentproteinserinethreoninekinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","a","protein","=","ADP","+","a","phosphoprotein",".","This","reaction","requires","binding","of","the","GTPase","Rho","."),4157354). assertion_content_comment('oboGo_RhodopsinLikereceptoractivity',s("OBSOLETE",".","A","G-protein","coupled","receptor","that","is","structurally/functionally","related","to","the","rhodopsin","receptor","."),4361415). assertion_content_comment('oboGo_RhodopsinMediatedGProteinsignalingcoupledtoip3secondmessenger',s("The","series","of","molecular","signals","generated","as","a","consequence","of","light","impinging","on","rhodopsin","molecules","in","a","photoreceptor","cell",",","followed","by","the","activation","of","phospholipase","C","and","the","subsequent","release","of","inositol","trisphosphate","."),4049066). assertion_content_comment('oboGo_RhoGDPDissociationinhibitoractivity',s("Prevents","the","dissociation","of","GDP","from","the","small","GTPase","Rho",",","thereby","preventing","GTP","from","binding","."),4215209). assertion_content_comment('oboGo_RhoGDPDissociationinhibitorbinding',s("Interacting","selectively","and","non-covalently","with","a","Rho","GDP-dissociation","inhibitor","protein","."),4279239). assertion_content_comment('oboGo_RhoGuanylNucleotideexchangefactoractivity',s("Stimulates","the","exchange","of","guanyl","nucleotides","associated","with","a","GTPase","of","the","Rho","family",".","Under","normal","cellular","physiological","conditions",",","the","concentration","of","GTP","is","higher","than","that","of","GDP",",","favoring","the","replacement","of","GDP","by","GTP","in","association","with","the","GTPase","."),4215540). assertion_content_comment('oboGo_Rhp55Rhp57complex',s("A","conserved","heterodimeric","DNA","recombinase","mediator","complex","that","contains","the","RecA","family","proteins","Rhp55p","and","Rph57","in","Schizosaccharomyces",",","or","orthologs","thereof","(","e.g",".","Rad55p","and","Rad57p","in","Saccharomyces",")"),4347379). assertion_content_comment('oboGo_Ribitol2Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","D-ribitol","+","NAD","(","+",")","=","D-ribulose","+","H","(","+",")","+","NADH","."),4263810). assertion_content_comment('oboGo_Ribitol_5_Phosphate2_DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","D-ribitol","5-phosphate","+","NAD","(","P",")","+","=","D-ribulose","5-phosphate","+","NAD","(","P",")","H","+","H","+"),4263825). assertion_content_comment('oboGo_RibitolCatabolicProcessToXylulose5Phosphate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","ribitol","to","form","xylulose","5-phosphate",".","Ribitol","is","initially","converted","to","D-ribulose",",","which","is","phosphorylated","to","form","ribulose","5-phosphate",",","which","is","then","converted","into","xylulose","5-phosphate","."),4241187). assertion_content_comment('oboGo_RibonucleasePolyUSpecificactivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","poly","(","U",")","to","fragments","terminated","by","3","'","-hydroxy","and","5","'","-phosphate","groups","."),4344011). assertion_content_comment('oboGo_RibonucleosideDiphosphatereductaseactivity',s("Catalysis","of","the","reaction",":","2","'","-deoxyribonucleoside","diphosphate","+","thioredoxin","disulfide","+","H2O","=","ribonucleoside","diphosphate","+","thioredoxin",".","Thioredoxin","disulfide","is","the","oxidized","form","of","thioredoxin","."),4201356). assertion_content_comment('oboGo_RibonucleosideDiphosphatereductasecomplex',s("An","enzyme","complex","composed","of","2-4","or","more","subunits",",","which","usually","contains","nonheme","iron","and","requires","ATP","for","catalysis",".","Catalyzes","the","formation","of","2","'","-deoxyribonucleoside","diphosphate","and","thioredoxin","disulfide","from","ribonucleoside","diphosphate","and","thioredoxin","."),4221349). assertion_content_comment('oboGo_RibonucleosideTriphosphatereductaseactivity',s("Catalysis","of","the","reaction",":","2","'","-deoxyribonucleoside","triphosphate","+","thioredoxin","disulfide","+","H2O","=","ribonucleoside","triphosphate","+","thioredoxin","."),4223433). assertion_content_comment('oboGo_Ribose15Bisphosphateisomeraseactivity',s("Catalysis","of","the","reaction",":","D-ribose","1",",","5-bisphosphate","=","D-ribulose","1",",","5-bisphosphate","."),4328663). assertion_content_comment('oboGo_Ribose15Bisphosphatephosphokinaseactivity',s("Catalysis","of","the","reaction",":","D-ribose","1",",","5-diphosphate","+","ATP","=","5-phospho-alpha-D-ribose","1-diphosphate","+","ADP","+","H","(","+",")"),4343706). assertion_content_comment('oboGo_Ribose1Dehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","NADP","(","+",")","+","ribofuranose","=","D-ribonate","+","2","H","(","+",")","+","NADPH","."),4263797). assertion_content_comment('oboGo_Ribose_5_PhosphateAdenylyltransferaseActivity',s("Catalysis","of","the","reaction",":","D-ribose","5-phosphate","+","ADP","+","H","(","+",")","=","ADP-ribose","+","phosphate","."),4368177). assertion_content_comment('oboGo_Ribose_5_Phosphate_AmmoniaLigaseActivity',s("Catalysis","of","the","reaction",":","D-ribose","5-phosphate","+","ATP","+","NH","(","4",")","(","+",")","=","5-phospho-D-ribosylamine","+","ADP","+","2","H","(","+",")","+","phosphate","."),4263926). assertion_content_comment('oboGo_Ribose_5_PhosphateIsomeraseActivity',s("Catalysis","of","the","reaction",":","D-ribose","5-phosphate","=","D-ribulose","5-phosphate","."),4201406). assertion_content_comment('oboGo_RibosomalProteinAlaninenAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","ribosomal-protein","L-alanine","=","CoA","+","ribosomal-protein","N-acetyl-L-alanine","."),4248215). assertion_content_comment('oboGo_RibosomalProteinAlaninenAcetyltransferasecomplex',s("An","enzyme","complex","that","catalyzes","the","transfer","of","an","acetyl","group","to","ribosomal-protein","alanine",",","forming","ribosomal-protein","acetylalanine","."),4259847). assertion_content_comment('oboGo_RibosomalS6Glutamicacidligaseactivity',s("Catalysis","of","the","posttranslational","transfer","of","one","or","more","glutamic","acid","residues","to","the","C-terminus","of","ribosomal","protein","S6","."),4284544). assertion_content_comment('oboGo_Ribulose_15_BisphosphateCarboxylaseOxygenaseActivatorActivity',s("Increases","the","activity","of","rubisco","by","the","removal","of","otherwise","inhibitory","sugar","phosphates",":","RuBP",",","and","in","some","plants",",","2-carboxyarabinitol","1-phosphate","."),4358353). assertion_content_comment('oboGo_RibuloseBisphosphatecarboxylaseactivity',s("Catalysis","of","the","reaction",":","D-ribulose","1",",","5-bisphosphate","+","CO2","+","H2O","=","2","3-phospho-D-glycerate","."),4302260). assertion_content_comment('oboGo_RibuloseBisphosphatecarboxylaseLysinenMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","[","ribulose-1",",","5-bisphosphate","carboxylase","]","-lysine","=","S-adenosyl-L-homocysteine","+","[","ribulose-1",",","5-bisphosphate","carboxylase","]","-N6-methyl-L-lysine","."),4309038). assertion_content_comment('oboGo_RibulosePhosphate3Epimeraseactivity',s("Catalysis","of","the","reaction",":","D-ribulose","5-phosphate","=","D-xylulose","5-phosphate","."),4201382). assertion_content_comment('oboGo_Ric1pRgp1pcomplex',s("A","protein","complex","that","acts","as","a","nucleotide","exchange","factor","for","the","GTPase","Ypt6p",",","and","is","required","for","fusion","of","endosome-derived","vesicles","with","the","Golgi","."),4361293). assertion_content_comment('oboGo_RieskeIronSulfurprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4345593). assertion_content_comment('oboGo_RifamycinBoxidaseactivity',s("Catalysis","of","the","reaction",":","2","H","(","+",")","+","O","(","2",")","+","rifamycin","B","=","H","(","2",")","O","(","2",")","+","rifamycin","O","."),4263902). assertion_content_comment('oboGo_RINGLikezincfingerdomainbinding',s("Interacting","selectively","and","non-covalently","with","a","RING-like","zinc","finger","domain","domain","of","a","protein",".","The","RING-like","domain","is","a","zinc","finger","domain","that","is","related","to","the","C3HC4","RING","finger","domain","."),4172018). assertion_content_comment('oboGo_RINGLikezincfingerdomainMediatedcomplexassembly',s("A","process","of","protein","complex","assembly","in","which","the","arrangement","and","bonding","together","of","the","set","of","components","that","form","the","protein","complex","is","mediated","by","a","RING-like","zinc","finger","domain","interaction","."),4172027). assertion_content_comment('oboGo_RipeningNonClimacteric',s("A","ripening","process","that","does","not","involve","a","respiratory","burst","."),4262585). assertion_content_comment('oboGo_RIPHomotypicInteractionMotifMediatedcomplexassembly',s("A","process","of","protein","complex","assembly","in","which","the","arrangement","and","bonding","together","of","the","set","of","components","that","form","the","protein","complex","is","mediated","by","a","RIP","homotypic","interaction","motif","(","RHIM",")","interaction","."),4171611). assertion_content_comment('oboGo_RISCLoadingcomplex',s("A","trimeric","ribonucleoprotein","complex","that","and","is","required","for","the","formation","of","a","mature","RNA","induced","silencing","complex","(","RISC",")","In","humans","the","complex","is","composed","of","the","endonuclease","Dicer","(","DICER1",")","and","TRBP","(","TARBP2",")","in","association","with","the","Argonaute","protein","Ago2","(","EIF2C2/AGO2",")","Within","the","complex",",","Dicer","and","TRBP","are","required","to","process","precursor","miRNAs","(","pre-miRNAs",")","to","mature","miRNAs","and","then","load","them","onto","Ago2",".","Ago2","bound","to","the","mature","miRNA","constitutes","the","minimal","RISC","and","may","subsequently","dissociate","from","Dicer","and","TRBP","."),4175149). assertion_content_comment('oboGo_RLactaldehydereductaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-propane-1",",","2-diol","+","NAD","+","=","(","R",")","-lactaldehyde","+","NADH","+","H","+"),4192012). assertion_content_comment('oboGo_RLimonene12Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","(","+",")","-","(","4R",")","-limonene","+","NAD","(","P",")","H","+","H","+","+","O2","=","NAD","(","P",")","+","+","H2O","+","(","4R",")","-limonene-1",",","2-epoxide","."),4275950). assertion_content_comment('oboGo_RLimonenesynthaseactivity',s("Catalysis","of","the","reaction",":","geranyl","diphosphate","=","(","4R",")","-limonene","+","diphosphate","."),4360513). assertion_content_comment('oboGo_RLinaloolsynthaseactivity',s("Catalysis","of","the","reaction",":","geranyl","diphosphate","+","H","(","2",")","O","=","(","R",")","-linalool","+","diphosphate","."),4360754). assertion_content_comment('oboGo_RMandelatecatabolicprocesstobenzoate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","(","R",")","-mandelate","into","other","compounds",",","including","benzoate","."),4243360). assertion_content_comment('oboGo_RMandelatecatabolicprocesstocatechol',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","(","R",")","-mandelate","into","other","compounds",",","including","catechol","."),4243373). assertion_content_comment('oboGo_RNA2ORibosemethylationguideactivity',s("Specifies","the","site","of","2","'","-O-ribose","methylation","in","an","RNA","molecule","by","base","pairing","with","a","short","sequence","around","the","target","residue","."),4310535). assertion_content_comment('oboGo_RNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","an","RNA","molecule","."),3974343). assertion_content_comment('oboGo_RNA_3_PhosphateCyclaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","RNA","3","'","-terminal-phosphate","=","AMP","+","diphosphate","+","RNA","terminal-2","'",",","3","'","-cyclic-phosphate","."),4185209). assertion_content_comment('oboGo_RNA5Endprocessing',s("Any","process","involved","in","forming","the","mature","5","'","end","of","an","RNA","molecule","."),3976175). assertion_content_comment('oboGo_RNA7Methylguanosinecapbinding',s("Interacting","selectively","and","non-covalently","with","the","7-methylguanosine","group","added","cotranscriptionally","to","the","5","'","end","of","RNA","molecules","transcribed","by","polymerase","II","."),4362872). assertion_content_comment('oboGo_RNAAdenosineUridineinsertion',s("The","modification","of","an","RNA","molecule","by","insertion","of","an","adenosine-uridine","dinucleotide","."),4176663). assertion_content_comment('oboGo_RNACytidineUridineinsertion',s("The","modification","of","an","RNA","molecule","by","insertion","of","an","cytidine-uridine","dinucleotide","."),4176727). assertion_content_comment('oboGo_RNADependentatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",";","this","reaction","requires","the","presence","of","RNA",",","and","it","drives","another","reaction","."),4213006). assertion_content_comment('oboGo_RNADependentdnareplication',s("A","DNA","replication","process","that","uses","RNA","as","a","template","for","RNA-dependent","DNA","polymerases","(","e.g",".","reverse","transcriptase",")","that","synthesize","the","new","strands","."),4055069). assertion_content_comment('oboGo_RNADirecteddnapolymeraseactivity',s("Catalysis","of","the","reaction",":","deoxynucleoside","triphosphate","+","DNA","(","n",")","=","diphosphate","+","DNA","(","n","+","1",")","Catalyzes","RNA-template-directed","extension","of","the","3","'","-","end","of","a","DNA","strand","by","one","deoxynucleotide","at","a","time","."),3974943). assertion_content_comment('oboGo_RNADirecteddnapolymerasegroupiiintronencoded',s("OBSOLETE",".","Catalysis","of","RNA-template-directed","extension","of","the","3","'","-","end","of","a","DNA","strand","by","one","deoxynucleotide","at","a","time",";","cannot","initiate","a","chain","de","novo","."),4187026). assertion_content_comment('oboGo_RNADirecteddnapolymerasetransposonencoded',s("OBSOLETE",".","Catalysis","of","RNA-template-directed","extension","of","the","3","'","-","end","of","a","DNA","strand","by","one","deoxynucleotide","at","a","time",";","cannot","initiate","a","chain","de","novo","."),4185198). assertion_content_comment('oboGo_RNADirectedrnapolymeraseactivity',s("Catalysis","of","the","reaction",":","nucleoside","triphosphate","+","RNA","(","n",")","=","diphosphate","+","RNA","(","n","+","1",")",";","uses","an","RNA","template","."),4186995). assertion_content_comment('oboGo_RNADirectedrnapolymerasecomplex',s("A","protein","complex","that","possesses","RNA-directed","RNA","polymerase","activity","."),4319780). assertion_content_comment('oboGo_RNAGuanosineCytidineinsertion',s("The","modification","of","an","RNA","molecule","by","insertion","of","an","guanosine-cytidine","dinucleotide","."),4176737). assertion_content_comment('oboGo_RNAGuanosineUridineinsertion',s("The","modification","of","an","RNA","molecule","by","insertion","of","an","guanosine-uridine","insertion","dinucleotide","."),4176747). assertion_content_comment('oboGo_RNAInducedsilencingcomplex',s("A","ribonucleoprotein","complex","that","contains","members","of","the","Argonaute","family","of","proteins",",","small","interfering","RNAs","(","siRNAs",")","or","microRNAs","(","miRNAs",")",",","and","miRNA","or","siRNA-complementary","mRNAs",",","in","addition","to","a","number","of","accessory","factors",".","The","RISC","complex","is","involved","in","posttranscriptional","repression","of","gene","expression","through","downregulation","of","translation","or","induction","of","mRNA","degradation","."),4304960). assertion_content_comment('oboGo_RNAMediateddnarecombination',s("The","reverse","transcription","of","an","RNA","molecule","followed","by","recombination","between","the","resultant","cDNA","and","its","homologous","chromosomal","allele","."),4313934). assertion_content_comment('oboGo_RNAPolymeraseICorePromoterSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","the","regulatory","region","composed","of","the","transcription","start","site","and","binding","sites","for","transcription","factors","of","the","RNA","polymerase","I","transcription","machinery",".","This","site","is","often","referred","to","as","the","core","element","."),4357778). assertion_content_comment('oboGo_RNAPolymeraseICorePromoterSequenceSpecificdnabindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","the","regulatory","region","composed","of","the","transcription","start","site","and","binding","sites","for","transcription","factors","of","the","RNA","polymerase","I","transcription","machinery","in","order","to","modulate","transcription","by","RNA","polymerase","I","."),4357700). assertion_content_comment('oboGo_RNAPolymeraseIEnhancerSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","RNA","polymerase","I","(","Pol","I",")","enhancer",".","In","mammalian","cells",",","enhancers","are","distal","sequences","that","increase","the","utilization","of","promoters",",","and","can","function","in","either","orientation","and","in","any","location","(","upstream","or","downstream",")","relative","to","the","core","promoter","."),4357768). assertion_content_comment('oboGo_RNAPolymeraseIEnhancerSequenceSpecificdnabindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","RNA","polymerase","I","(","Pol","I",")","enhancer","in","order","to","modulate","transcription","by","RNA","polymerase","I","."),4358056). assertion_content_comment('oboGo_RNAPolymeraseIICarboxyTerminaldomainkinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","(","DNA-directed","RNA","polymerase","II",")","=","ADP","+","phospho-","(","DNA-directed","RNA","polymerase","II",")",";","phosphorylation","occurs","on","residues","in","the","carboxy-terminal","domain","(","CTD",")","repeats","."),4255182). assertion_content_comment('oboGo_RNAPolymeraseIICorePromoterProximalRegionSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","in","cis","with","and","relatively","close","to","a","core","promoter","for","RNA","polymerase","II","."),4363376). assertion_content_comment('oboGo_RNAPolymeraseIICorePromoterProximalRegionSequenceSpecificdnabindingtranscriptionfactoractivityinvolvedinnegativeregulationoftranscription',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","in","cis","with","and","relatively","close","to","a","core","promoter","for","RNA","polymerase","II","(","RNAP","II",")","in","order","to","stop",",","prevent",",","or","reduce","the","frequency",",","rate","or","extent","of","transcription","from","an","RNA","polymerase","II","promoter","."),4355816). assertion_content_comment('oboGo_RNAPolymeraseIICorePromoterProximalRegionSequenceSpecificdnabindingtranscriptionfactoractivityinvolvedinpositiveregulationoftranscription',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","in","cis","with","and","relatively","close","to","a","core","promoter","for","RNA","polymerase","II","(","RNAP","II",")","in","order","to","activate","or","increase","the","frequency",",","rate","or","extent","of","transcription","from","the","RNAP","II","promoter","."),4355825). assertion_content_comment('oboGo_RNAPolymeraseIICorePromoterProximalRegionSequenceSpecificdnabindingtranscriptionfactoractivityinvolvedinpreinitiationcomplexassembly',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","in","cis","with","and","relatively","close","to","a","core","promoter","for","RNA","polymerase","II","(","RNAP","II",")","in","order","to","promote","formation","of","the","transcriptional","preinitiation","complex","(","PIC",")",",","the","formation","of","which","is","a","prerequisite","for","transcription","from","the","RNA","polymerase","II","promoter","."),4355852). assertion_content_comment('oboGo_RNAPolymeraseIICorePromoterProximalRegionSequenceSpecificdnabindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","in","cis","with","and","relatively","close","to","a","core","promoter","for","RNA","polymerase","II","(","RNAP","II",")","in","order","to","modulate","transcription","by","RNAP","II","."),4355814). assertion_content_comment('oboGo_RNAPolymeraseIICorePromoterSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","the","regulatory","region","composed","of","the","transcription","start","site","and","binding","sites","for","transcription","factors","of","the","RNA","polymerase","II","basal","transcription","machinery","."),4363366). assertion_content_comment('oboGo_RNAPolymeraseIICorePromoterSequenceSpecificdnabindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","in","an","RNA","polymerase","II","(","Pol","II",")","core","promoter",",","the","region","composed","of","the","transcription","start","site","and","binding","sites","for","transcription","factors","of","the","Pol","II","basal","transcription","machinery",",","in","order","to","modulate","transcription","by","Pol","II",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","a","protein","or","macromolecular","complex","."),4355841). assertion_content_comment('oboGo_RNAPolymeraseIIEnhancerSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","RNA","polymerase","II","(","Pol","II",")","enhancer",".","In","mammalian","cells",",","enhancers","are","distal","sequences","that","increase","the","utilization","of","some","promoters",",","and","can","function","in","either","orientation","and","in","any","location","(","upstream","or","downstream",")","relative","to","the","core","promoter","."),4363399). assertion_content_comment('oboGo_RNAPolymeraseIIIHybridTypePromoterSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","a","part","of","a","hybrid","type","promoter","that","controls","transcription","by","RNA","polymerase","III","(","Pol","III",")","A","hybrid","Pol","III","promoter","contains","both","regulatory","elements","both","upstream","and","downstream","of","the","transcription","initiation","site",".","An","example","gene","with","such","a","promoter","is","the","S",".","cerevisiae","U6","gene","."),4356520). assertion_content_comment('oboGo_RNAPolymeraseIIIHybridTypePromoterTFIIIBTypetranscriptionfactoractivity',s("Once","recruited","to","an","RNA","polymerase","III","hybrid","type","promoter",",","binds","to","DNA",",","recruits","RNA","polymerase","III","and","facilitates","the","transition","from","the","closed","to","the","open","complex","."),4356298). assertion_content_comment('oboGo_RNAPolymeraseIIIntronicTranscriptionRegulatoryRegionSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","an","RNA","polymerase","II","intronic","DNA","sequence","that","regulates","the","transcription","of","the","transcript","it","is","contained","within","."),4357809). assertion_content_comment('oboGo_RNAPolymeraseIIIPromoterSequenceSpecificdnabindingtfiiibrecruitingtranscriptionfactoractivity',s("The","function","of","binding","to","a","specific","DNA","sequence","motif","in","an","RNA","polymerase","III","(","Pol","III",")","promoter","in","order","to","recruit","the","Pol","III","recruiting","factor","TFIIIB","to","the","promoter","."),4356497). assertion_content_comment('oboGo_RNAPolymeraseIIIType1PromoterSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","a","part","of","a","type","1","promoter","that","controls","transcription","by","RNA","polymerase","III",".","Type","1","promoters","are","found","in","5S","rRNA","genes",",","downstream","of","the","transcription","start","site","within","the","sequence","of","the","mature","RNA",",","and","require","TFIIIA","for","recognition","."),4356972). assertion_content_comment('oboGo_RNAPolymeraseIIIType1PromoterSequenceSpecificdnabindingtfiiibrecruitingtranscriptionfactoractivity',s("The","function","of","binding","to","a","specific","DNA","sequence","motif","in","a","type","1","RNA","polymerase","III","(","Pol","III",")","promoter","in","order","to","recruit","the","Pol","III","recruiting","factor","TFIIIB","to","the","promoter",".","For","type","1","Pol","III","promoters",",","this","requires","both","TFIIIA","and","TFIIIC","."),4356927). assertion_content_comment('oboGo_RNAPolymeraseIIIType1PromoterSequenceSpecificdnabindingtfiiicrecruitingtranscriptionfactoractivity',s("The","function","of","binding","to","a","specific","DNA","sequence","motif","in","a","type","1","RNA","polymerase","III","(","Pol","III",")","promoter","in","order","to","recruit","the","transcription","factor","TFIIIC","to","the","promoter","."),4358002). assertion_content_comment('oboGo_RNAPolymeraseIIIType1PromoterTFIIIBTypetranscriptionfactoractivity',s("Once","recruited","to","an","RNA","polymerase","III","type","1","promoter","by","TFIIIA-type","and","TFIIIC-type","factors",",","binds","to","DNA",",","recruits","RNA","polymerase","III","and","facilitates","the","transition","from","the","closed","to","the","open","complex","."),4356710). assertion_content_comment('oboGo_RNAPolymeraseIIIType2PromoterSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","a","part","of","a","type","2","promoter","that","controls","transcription","by","RNA","polymerase","III",".","Type","2","promoters","consist","of","an","A","box","and","a","B","box","downstream","of","the","transcription","start","site","within","the","sequence","within","the","sequence","of","the","mature","RNA",".","Type","2","promoters","are","found","in","many","tRNA","genes","as","well","as","in","other","small","RNAs","."),4356962). assertion_content_comment('oboGo_RNAPolymeraseIIIType2PromoterSequenceSpecificdnabindingtfiiibrecruitingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","motif","in","a","type","2","RNA","polymerase","III","(","Pol","III",")","promoter","in","order","to","recruit","TFIIIB","to","the","promoter",".","For","type","2","Pol","III","promoters",",","this","requires","TFIIIC","activity","."),4356720). assertion_content_comment('oboGo_RNAPolymeraseIIIType2PromoterTFIIIBTypetranscriptionfactoractivity',s("Once","recruited","to","an","RNA","polymerase","III","type","2","promoter","by","a","TFIIIC-type","factor",",","binds","to","DNA",",","recruits","RNA","polymerase","III","and","facilitates","the","transition","from","the","closed","to","the","open","complex","."),4356689). assertion_content_comment('oboGo_RNAPolymeraseIIIType3PromoterSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","is","a","part","of","a","type","3","promoter","that","controls","transcription","by","RNA","polymerase","III","(","Pol","III",")","A","type","3","Pol","III","promoter","is","composed","of","elements","upstream","of","the","transcription","start","site",",","including","a","TATA","box",".","The","human","U6","snRNA","gene","has","a","type","3","promoter",".","Type","3","Pol","III","promoters","have","not","been","observed","in","S",".","cerevisiae","."),4356906). assertion_content_comment('oboGo_RNAPolymeraseIIIType3PromoterTFIIIBTypetranscriptionfactoractivity',s("Once","recruited","to","an","RNA","polymerase","III","type","3","promoter","by","SNAP-type","and","TFIIIC-type","factors",",","binds","to","DNA",",","recruits","RNA","polymerase","III","and","facilitates","the","transition","from","the","closed","to","the","open","complex","."),4356669). assertion_content_comment('oboGo_RNAPolymeraseIIRegulatoryRegionSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","specific","sequence","of","DNA","that","is","part","of","a","regulatory","region","that","controls","the","transcription","of","a","gene","or","cistron","by","RNA","polymerase","II","."),4357806). assertion_content_comment('oboGo_RNAPolymeraseIRegulatoryRegionSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","specific","sequence","of","DNA","that","is","part","of","a","regulatory","region","that","controls","the","transcription","of","a","gene","or","cistron","by","RNA","polymerase","I","."),4357736). assertion_content_comment('oboGo_RNAPolymeraseIUpstreamControlElementSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","the","upstream","control","element","(","UCE",",","or","alternately","referred","to","as","the","upstream","element",")",",","a","sequence","of","DNA","that","is","in","cis","with","and","relatively","close","to","a","core","promoter","for","RNA","polymerase","I","."),4357738). assertion_content_comment('oboGo_RNAPolymeraseIUpstreamControlElementSequenceSpecificdnabindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","the","upstream","control","element","(","UCE",",","or","alternately","referred","to","as","the","upstream","element",",","UE",")",",","a","sequence","of","DNA","that","is","in","cis","with","and","relatively","close","to","a","core","promoter","for","RNA","polymerase","I","in","order","to","modulate","transcription","by","RNA","polymerase","I","."),4357719). assertion_content_comment('oboGo_RNAProteincovalentcrossLinking',s("The","formation","of","a","covalent","cross-link","between","RNA","and","a","protein","."),4280306). assertion_content_comment('oboGo_RNAProteincovalentcrossLinkingviapeptidylSerine',s("The","formation","of","a","covalent","cross-link","between","RNA","and","a","peptidyl-serine","residue","by","the","formation","of","O-","(","phospho-5","'","-5NA",")","-L-serine","."),4280309). assertion_content_comment('oboGo_RNAProteincovalentcrossLinkingviapeptidylTyrosine',s("The","formation","of","a","covalent","cross-link","between","RNA","and","a","peptidyl-tyrosine","residue","by","the","formation","of","O4","'","-","(","phospho-5","'","-RNA",")","-L-tyrosine","."),4284791). assertion_content_comment('oboGo_RNAStemLoopbinding',s("Interacting","selectively","and","non-covalently","with","a","stem-loop","in","an","RNA","molecule",".","An","RNA","stem-loop","is","a","secondary","RNA","structure","consisting","of","a","double-stranded","RNA","(","dsRNA",")","stem","and","a","terminal","loop","."),4379606). assertion_content_comment('oboGo_RNAStrandExchangeactivity',s("Facilitates","the","displacement","of","one","strand","of","an","RNA-RNA","duplex","and","its","replacement","with","a","different","strand","of","higher","complementarity","."),4360777). assertion_content_comment('oboGo_RPantolactonedehydrogenaseflavinactivity',s("Catalysis","of","the","reaction",":","(","R",")","-pantolactone","+","A","=","2-dehydropantolactone","+","AH","(","2",")"),4364747). assertion_content_comment('oboGo_Rpd3LExpandedcomplex',s("A","protein","complex","that","contains","a","histone","deacetylase","and","is","part","of","the","chromatin","remodeling","machinery",".","In","Saccharomyces","cerevisiae","this","complex","contains","the","Rpd3p",",","Sin3p",",","Ume1p",",","Pho23p",",","Sap30p",",","Sds3p",",","Cti6p",",","Rxt2p",",","Rxt3p",",","Dep1p",",","Ume6p",",","Ash1p",",","Dot6p",",","Snt1",",","Sif2p",",","Set3p",",","Hos2p",",","Tos4p","and","Tod6p","proteins","."),4137382). assertion_content_comment('oboGo_RPTPLikeproteinbinding',s("Interacting","selectively","and","non-covalently","with","proteins","with","similar","structure/function","to","receptor","protein","tyrosine","phosphatases","."),4313912). assertion_content_comment('oboGo_RRButanedioldehydrogenaseactivity',s("Catalysis","of","the","reversible","reaction",":","(","R",",","R",")","-butane-2",",","3-diol","+","NAD","+","=","(","R",")","-acetoin","+","NADH","+","H","+"),4363819). assertion_content_comment('oboGo_RRNA2OMethylation',s("The","addition","of","a","methyl","group","to","the","2","'","-oxygen","atom","of","a","nucleotide","residue","in","an","rRNA","molecule","during","ribosome","biogenesis","."),4362480). assertion_content_comment('oboGo_RRNA2ORibosemethylationguideactivity',s("Specifies","the","site","of","2","'","-O-ribose","methylation","in","an","rRNA","molecule","by","base","pairing","with","a","short","sequence","around","the","target","residue","."),4310568). assertion_content_comment('oboGo_RRNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","an","rRNA","molecule","."),3976100). assertion_content_comment('oboGo_RRNA5Endprocessing',s("Any","process","involved","in","forming","the","mature","5","'","end","of","an","rRNA","molecule","."),3976182). assertion_content_comment('oboGo_RRNAAdenineC2Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","C2-methyladenine","."),4180555). assertion_content_comment('oboGo_RRNAAdenineN6Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","N6-methyladenine","."),4248008). assertion_content_comment('oboGo_RRNAAdenineN6n6Dimethyltransferaseactivity',s("Catalysis","of","the","dimethylation","two","adjacent","A","residues","in","the","loop","closing","the","3","'","-terminal","stem","of","the","18S","rRNA",",","using","S-adenosyl-L-methionine","as","a","methyl","donor","."),4346067). assertion_content_comment('oboGo_RRNAAdenosine_2_O__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","a","single","residue","of","2","'","-O-methyladenosine","."),4308777). assertion_content_comment('oboGo_RRNAContainingribonucleoproteincomplexexportfromnucleus',s("The","directed","movement","of","a","ribonucleoprotein","complex","that","contains","ribosomal","RNA","from","the","nucleus","to","the","cytoplasm","."),3970146). assertion_content_comment('oboGo_RRNACytosine_2_O__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","2","'","-O-methylcytosine","."),4177349). assertion_content_comment('oboGo_RRNACytosineC5Methyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosyl-L-methionine","to","cytosine","to","form","5-methylcytosine","in","small","subunit","ribosomal","RNA","."),4259996). assertion_content_comment('oboGo_RRNACytosineN4Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","N4-methylcytosine","."),4164166). assertion_content_comment('oboGo_RRNAGuanineN1Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","N1-methylguanine","."),4248026). assertion_content_comment('oboGo_RRNAGuanineN2Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","N2-methylguanine","."),4248280). assertion_content_comment('oboGo_RRNAGuanineN7Methylation',s("The","addition","of","a","methyl","group","to","the","N7","atom","in","the","base","portion","of","a","guanine","nucleotide","residue","in","an","rRNA","molecule","."),4175885). assertion_content_comment('oboGo_RRNAGuanineN7Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","N7-methylguanine","."),4180492). assertion_content_comment('oboGo_RRNAGuanosine_2_O__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","2","'","-O-methylguanosine","."),4180622). assertion_content_comment('oboGo_RRNANGlycosylaseactivity',s("Catalysis","of","the","hydrolysis","of","the","N-glycosylic","bond","at","A-4324","in","28S","rRNA","from","rat","ribosomes","or","corresponding","sites","in","28S","RNA","from","other","species","."),4307865). assertion_content_comment('oboGo_RRNAPseudouridineN3Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","N3-methylpseudouridine","."),4180642). assertion_content_comment('oboGo_RRNAUridine_2_O__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","2","'","-O-methyluridine","."),4253216). assertion_content_comment('oboGo_RRNAUridineC5Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","C5-methyluridine","."),4180534). assertion_content_comment('oboGo_RRNAUridineN3Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","rRNA","=","S-adenosyl-L-homocysteine","+","rRNA","containing","N3-methyluridine","."),4180513). assertion_content_comment('oboGo_RS_1_Benzyl_1234_TetrahydroisoquinolineN_MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","(","RS",")","-1-benzyl-1",",","2",",","3",",","4-tetrahydroisoquinoline","=","S-adenosyl-L-homocysteine","+","N-methyl-","(","RS",")","-1-benzyl-1",",","2",",","3",",","4-tetrahydroisoquinoline","."),4309176). assertion_content_comment('oboGo_RSmadbinding',s("Interacting","selectively","and","non-covalently","with","a","receptor-regulated","SMAD","signaling","protein","."),4175512). assertion_content_comment('oboGo_RSNorcoclaurine6OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","(","RS",")","-norcoclaurine","=","S-adenosyl-L-homocysteine","+","(","RS",")","-coclaurine","."),4309055). assertion_content_comment('oboGo_RubberCisPolyprenylcistransferaseactivity',s("Catalysis","of","the","reaction",":","poly-cis-polyprenyl","diphosphate","+","isopentenyl","diphosphate","=","diphosphate","+","a","poly-cis-polyprenyl","diphosphate","longer","by","one","C5","unit","."),4263973). assertion_content_comment('oboGo_Rubredoxin_NADPReductaseActivity_2',s("Catalysis","of","the","reaction",":","reduced","rubredoxin","+","NADP","+","=","oxidized","rubredoxin","+","NADPH","+","H","+"),4296926). assertion_content_comment('oboGo_RubredoxinNadpreductaseactivity',s("Catalysis","of","the","reaction",":","reduced","rubredoxin","+","NAD","(","P",")","+","=","oxidized","rubredoxin","+","NAD","(","P",")","H","+","H","+"),4296909). assertion_content_comment('oboGo_RubredoxinNadreductaseactivity',s("Catalysis","of","the","reaction",":","reduced","rubredoxin","+","NAD","+","=","oxidized","rubredoxin","+","NADH","+","H","+"),4296947). assertion_content_comment('oboGo_RyanodineSensitivecalciumReleasechannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","calcium","ion","by","a","channel","that","opens","when","a","ryanodine","class","ligand","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4217574). assertion_content_comment('oboGo_S_23_Di_O_GeranylgeranylglycerylPhosphateSynthaseActivity',s("Catalysis","of","the","transfer","of","a","geranylgeranyl","group","from","geranylgeranyl","diphosphate","to","(","S",")","-3-O-geranylgeranylglyceryl","phosphate","to","form","(","S",")","-2",",","3-di-O-geranylgeranylglyceryl","phosphate","."),4328907). assertion_content_comment('oboGo_S_2_5_Amino_1_5_Phospho_D_RibosylImidazole_4_CarboxamidoSuccinateAMP_LyaseFumarate_FormingActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2-","(","5-amino-1-","(","5-phospho-D-ribosyl",")","imidazole-4-carboxamido",")","succinate","=","fumarate","+","5-amino-1-","(","5-phospho-D-ribosyl",")","imidazole-4-carboxamide","."),4177035). assertion_content_comment('oboGo_S_2_HaloacidDehalogenaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2-haloacid","+","H2O","=","(","R",")","-2-hydroxyacid","+","halide","."),4274296). assertion_content_comment('oboGo_S_2_Hydroxy_AcidOxidaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2-hydroxy-acid","+","O2","=","2-oxo","acid","+","hydrogen","peroxide","."),4186884). assertion_content_comment('oboGo_S_2_Hydroxy_FattyAcidDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-2-hydroxystearate","+","NAD","(","+",")","=","2-oxostearate","+","H","(","+",")","+","NADH","."),4364847). assertion_content_comment('oboGo_S_2_MethylmalateDehydrataseActivity',s("Catalysis","of","the","reaction",":","S-citramalate","=","H","(","2",")","O","+","mesaconate","."),4371628). assertion_content_comment('oboGo_S_3_Amino_2_MethylpropionateTransaminaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-amino-2-methylpropanoate","+","2-oxoglutarate","=","2-methyl-3-oxopropanoate","+","L-glutamate","."),4367678). assertion_content_comment('oboGo_S_3_Hydroxyacid_EsterDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","ethyl","(","S",")","-3-hydroxyhexanoate","+","NADP","(","+",")","=","ethyl","3-oxohexanoate","+","H","(","+",")","+","NADPH","."),4365953). assertion_content_comment('oboGo_S_3_O_GeranylgeranylglycerylPhosphateSynthaseActivity',s("Catalysis","of","the","alkylation","of","the","primary","hydroxyl","group","in","(","S",")","-glyceryl","phosphate","by","geranylgeranyl","diphosphate","to","form","(","S",")","-3-O-geranylgeranylglyceryl","phosphate","."),4328891). assertion_content_comment('oboGo_S_6_HydroxynicotineOxidaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-6-hydroxynicotine","+","H","(","2",")","O","+","O","(","2",")","=","6-hydroxypseudooxynicotine","+","H","(","2",")","O","(","2",")"),4278115). assertion_content_comment('oboGo_SabineneHydratesynthaseactivity',s("Catalysis","of","the","reaction",":","geranyl","diphosphate","+","H","(","2",")","O","=","diphosphate","+","sabinene","hydrate","."),4266207). assertion_content_comment('oboGo_Sabinoldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","+",")","-cis-sabinol","+","NAD","(","+",")","=","(","1S",",","5S",")","-sabinone","+","H","(","+",")","+","NADH","."),4371740). assertion_content_comment('oboGo_SaccharopineDehydrogenaseNADLGlutamateFormingactivity',s("Catalysis","of","the","reaction",":","L-saccharopine","+","H","(","2",")","O","+","NAD","(","+",")","=","L-glutamate","+","allysine","+","H","(","+",")","+","NADH","."),4365692). assertion_content_comment('oboGo_SaccharopineDehydrogenaseNADLLysineFormingactivity',s("Catalysis","of","the","reaction",":","L-saccharopine","+","H","(","2",")","O","+","NAD","(","+",")","=","2-oxoglutarate","+","L-lysine","+","H","(","+",")","+","NADH","."),4201437). assertion_content_comment('oboGo_SaccharopineDehydrogenaseNADPLGlutamateFormingactivity',s("Catalysis","of","the","reaction",":","L-saccharopine","+","H","(","2",")","O","+","NADP","(","+",")","=","L-allysine","+","L-glutamate","+","H","(","+",")","+","NADPH","."),4201452). assertion_content_comment('oboGo_SaccharopineDehydrogenaseNADPLLysineFormingactivity',s("Catalysis","of","the","reaction",":","L-saccharopine","+","H","(","2",")","O","+","NADP","(","+",")","=","2-oxoglutarate","+","L-lysine","+","H","(","+",")","+","NADPH","."),4365678). assertion_content_comment('oboGo_SAcetyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","acetyl","group","to","a","sulfur","atom","on","the","acceptor","molecule","."),4201162). assertion_content_comment('oboGo_SAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","acyl","group","to","a","sulfur","atom","on","the","acceptor","molecule","."),4201160). assertion_content_comment('oboGo_SAdenosylhomocysteinecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","S-adenosylhomocysteine",",","forming","homocysteine","and","then","methionine","."),4242317). assertion_content_comment('oboGo_SAdenosylhomocysteinedeaminaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-homocysteine","+","H","(","2",")","O","+","H","(","+",")","=","S-inosyl-L-homocysteine","+","NH","(","4",")","(","+",")"),4264071). assertion_content_comment('oboGo_SAdenosylhomocysteinemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","S-adenosylhomocysteine",";","the","L-enantiomer","is","formed","from","S-adenosylmethionine","and","is","a","strong","inhibitor","of","S-adenosylmethionine-mediated","methylation","reactions",".","It","can","be","cleaved","to","form","adenosine","and","homocysteine","."),4242314). assertion_content_comment('oboGo_SAdenosylLMethionine_Benzoicacidcarboxylmethyltransferaseactivity',s("Catalysis","of","the","reaction",":","benzoate","+","S-adenosyl-L-methionine","=","methylbenzoate","+","S-adenosyl-L-homocysteine","."),4181031). assertion_content_comment('oboGo_SAdenosylmethioninaminebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","S-adenosylmethioninamine",",","(","5-deoxy-5-adenosyl",")","(","3-aminopropyl",")","methylsulfonium","salt","."),4231666). assertion_content_comment('oboGo_SAdenosylmethioninaminemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","S-adenosylmethioninamine",",","(","5-deoxy-5-adenosyl",")","(","3-aminopropyl",")","methylsulfonium","salt","."),4231663). assertion_content_comment('oboGo_SAdenosylmethioninebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","S-adenosylmethionine",",","S-","(","5","'","-adenosyl",")","-L-methionine",",","an","important","intermediate","in","one-carbon","metabolism","."),4231630). assertion_content_comment('oboGo_SAdenosylmethioninecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","S-adenosylmethionine",",","S-","(","5","'","-adenosyl",")","-L-methionine",",","an","important","intermediate","in","one-carbon","metabolism","."),4274546). assertion_content_comment('oboGo_SAdenosylmethioninecycle',s("A","cyclic","series","of","interconversions","involving","S-adenosylmethionine",",","S-adenosyl-L-homocysteine",",","L-cysteine",",","and","L-methionine",".","Couples","utilization","of","the","methyl","group","of","SAM","with","recycling","of","the","homocysteinyl","group","and","regeneration","of","methionine","."),4045914). assertion_content_comment('oboGo_SAdenosylmethionineDependentmethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosyl-L-methionine","to","a","substrate","."),4164158). assertion_content_comment('oboGo_SAdenosylmethionineDependenttrnam5u54methyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosyl-L-methionine","to","the","C5","atom","of","the","uridine","residue","at","position","54","in","a","tRNA","molecule","."),4308420). assertion_content_comment('oboGo_SAdenosylmethioninemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","S-adenosylmethionine",",","S-","(","5","'","-adenosyl",")","-L-methionine",",","an","important","intermediate","in","one-carbon","metabolism","."),4045908). assertion_content_comment('oboGo_SAdenosylmethioninetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","S-adenosylmethionine","from","one","side","of","a","membrane","to","the","other",".","S-adenosylmethionine","is","S-","(","5","'","-adenosyl",")","-L-methionine",",","an","important","intermediate","in","one-carbon","metabolism","."),4345729). assertion_content_comment('oboGo_SAdenosylmethioninetransport',s("The","directed","movement","of","S-adenosylmethionine",",","S-","(","5","'","-adenosyl",")","-L-methionine",",","an","important","intermediate","in","one-carbon","metabolism",",","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293708). assertion_content_comment('oboGo_SAdenosylmethionine_TrnaribosyltransferaseIsomeraseactivity',s("Catalysis","of","the","reaction",":","S-adenosylmethionine","+","7-","(","aminomethyl",")","-7-deazaguanosine-tRNA","=","adenine","+","methionine","+","epoxyqueuosine-tRNA",".","7-","(","aminomethyl",")","-7-deazaguanosine-tRNA","is","also","known","as","preQ1-tRNA",",","and","epoxyqueuosine-tRNA","as","oQ-tRNA","."),4287052). assertion_content_comment('oboGo_SAGATypecomplex',s("A","histone","acetyltransferase","complex","that","acetylates","nucleosomal","H3","and","H2B","and","is","required","for","the","expression","of","a","subset","of","Pol","II-transcribed","genes",".","The","budding","yeast","complex","includes","the","acetyltransferase","Gcn5p",",","several","proteins","of","the","Spt","and","Ada","families",",","and","several","TBP-associate","proteins","(","TAFs",")",";","analogous","complexes","in","other","species","have","analogous","compositions",",","and","usually","contain","homologs","of","the","yeast","proteins","."),4066473). assertion_content_comment('oboGo_SalicylAlcoholbetaDGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","salicyl","alcohol","+","UDP-D-glucose","=","H","(","+",")","+","salicin","+","UDP","."),4264017). assertion_content_comment('oboGo_Salicylate1Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","salicylate","+","NADH","+","H","+","+","O2","=","catechol","+","NAD","+","+","H2O","+","CO2","."),4276158). assertion_content_comment('oboGo_Salicylate5Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","salicylate","+","O2","+","NAD","(","P",")","H","+","H","+","=","gentisate","+","H2O","+","NAD","(","P",")","+"),4349565). assertion_content_comment('oboGo_SalicylicAcidGlucosyltransferaseEsterFormingactivity',s("Catalysis","of","the","reaction",":","salicylic","acid","+","UDP-glucose","=","salicylic","acid","glucose","ester","+","UDP","."),4191640). assertion_content_comment('oboGo_SalicylicAcidGlucosyltransferaseGlucosideFormingactivity',s("Catalysis","of","the","reaction",":","salicylic","acid","+","UDP-glucose","=","salicylic","acid","2-O-glucoside","+","UDP","."),4191654). assertion_content_comment('oboGo_SAlkylcysteinelyaseactivity',s("Catalysis","of","the","reaction",":","an","S-alkyl-L-cysteine","+","H2O","=","an","alkyl","thiol","+","NH3","+","pyruvate","."),4264053). assertion_content_comment('oboGo_SAlkylthiohydroximatelyaseactivity',s("Catalysis","of","the","conversion","of","a","S-alkylthiohydroximate","to","a","thiohydroximate","."),4181460). assertion_content_comment('oboGo_Salutaridinol7OAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","7S",")","-salutaridinol","+","acetyl-CoA","=","(","7S",")","-O-acetylsalutaridinol","+","CoA","."),4366213). assertion_content_comment('oboGo_SarcosineDimethylglycineNMethyltransferaseactivity',s("Catalysis","of","the","reactions",":","S-adenosyl-L-methionine","+","sarcosine","=","S-adenosyl-L-homocysteine","+","N",",","N-dimethylglycine",",","and","S-adenosyl-L-methionine","+","N",",","N-dimethylglycine","=","S-adenosyl-L-homocysteine","+","betaine","."),4342951). assertion_content_comment('oboGo_SarGuanylNucleotideexchangefactoractivity',s("Stimulates","the","exchange","of","guanyl","nucleotides","associated","with","a","GTPase","of","the","Sar","family",".","Under","normal","cellular","physiological","conditions",",","the","concentration","of","GTP","is","higher","than","that","of","GDP",",","favoring","the","replacement","of","GDP","by","GTP","in","association","with","the","GTPase","."),4215249). assertion_content_comment('oboGo_Sarsapogenin3BetaGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","25S",")","-5beta-spirostan-3beta-ol","+","UDP-D-glucose","=","(","25S",")","-5beta-spirostan-3beta-yl","beta-D-glucoside","+","H","(","+",")","+","UDP","."),4366749). assertion_content_comment('oboGo_SatelliteDNABinding_2',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4222485). assertion_content_comment('oboGo_SC5b_7Complex',s("A","protein","complex","that","consist","of","complement","components","C5b6","and","C7","stably","inserted","in","a","cell","membrane",".","Formation","of","the","SC5b-7","complex","is","the","first","phase","of","membrane","attack","complex","assembly","."),4072367). assertion_content_comment('oboGo_SCanadinesynthaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-tetrahydrocolumbamine","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","(","S",")","-canadine","+","2","H","(","2",")","O","+","NADP","(","+",")"),4364904). assertion_content_comment('oboGo_SCarboxymethylcysteinesynthaseactivity',s("Catalysis","of","the","reaction",":","3-chloro-L-alanine","+","thioglycolate","=","S-carboxymethyl-L-cysteine","+","chloride","+","H","(","+",")"),4264041). assertion_content_comment('oboGo_SCarnitine3Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-carnitine","+","NAD","(","+",")","=","3-dehydrocarnitine","+","H","(","+",")","+","NADH","."),4364237). assertion_content_comment('oboGo_SCFDependentproteasomalubiquitinDependentproteincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds",",","initiated","by","the","covalent","attachment","of","ubiquitin",",","with","ubiquitin-protein","ligation","catalyzed","by","an","SCF","(","Skp1/Cul1/F-box","protein",")","complex",",","and","mediated","by","the","proteasome","."),4318826). assertion_content_comment('oboGo_SCheilanthifolinesynthaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-scoulerine","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","(","S",")","-cheilanthifoline","+","2","H","(","2",")","O","+","NADP","(","+",")"),4364893). assertion_content_comment('oboGo_SchmidtLantermanincisure',s("Regions","within","compact","myelin","in","which","the","cytoplasmic","faces","of","the","enveloping","myelin","sheath","are","not","tightly","juxtaposed",",","and","include","cytoplasm","from","the","cell","responsible","for","making","the","myelin",".","Schmidt-Lanterman","incisures","occur","in","the","compact","myelin","internode",",","while","lateral","loops","are","analogous","structures","found","in","the","paranodal","region","adjacent","to","the","nodes","of","Ranvier","."),4093096). assertion_content_comment('oboGo_SCoclaurineNMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","(","S",")","-coclaurine","=","S-adenosyl-L-homocysteine","+","(","S",")","-N-methylcoclaurine","."),4309078). assertion_content_comment('oboGo_ScribApcBetaCatenincomplex',s("A","protein","complex","that","contains","the","Scribble","protein","(","a","cell","polarity","determinant",")",",","the","tumor","suppressor","protein","adenomatous","polyposis","coli","(","APC",")",",","and","beta-catenin",";","may","be","involved","in","the","control","of","cell","proliferation","."),4349522). assertion_content_comment('oboGo_ScribApccomplex',s("A","protein","complex","that","contains","the","Scribble","protein","(","a","cell","polarity","determinant",")","and","the","tumor","suppressor","protein","adenomatous","polyposis","coli","(","APC",")",";","may","be","involved","in","the","control","of","cell","proliferation","."),4349450). assertion_content_comment('oboGo_ScylloInosamine4Kinaseactivity',s("Catalysis","of","the","reaction",":","1-amino-1-deoxy-scyllo-inositol","+","ATP","=","1-amino-1-deoxy-scyllo-inositol","4-phosphate","+","ADP","+","2","H","(","+",")"),4263990). assertion_content_comment('oboGo_Scyllo_Inosamine_4_PhosphateAmidinotransferaseActivity',s("Catalysis","of","the","reaction",":","1-amino-1-deoxy-scyllo-inositol","4-phosphate","+","L-arginine","=","1-guanidino-1-deoxy-scyllo-inositol","4-phosphate","+","L-ornithine","."),4297164). assertion_content_comment('oboGo_SecondaryAlcoholoxidaseactivity',s("Catalysis","of","the","reaction",":","O","(","2",")","+","secondary","alcohol","=","H","(","2",")","O","(","2",")","+","ketone","."),4341966). assertion_content_comment('oboGo_SecondMessengerMediatedsignaling',s("A","series","of","molecular","signals","in","which","an","ion","or","small","molecule","is","formed","or","released","into","the","cytosol",",","thereby","helping","relay","the","signal","within","the","cell","."),4024711). assertion_content_comment('oboGo_SecondU12Typespliceosomaltransesterificationactivity',s("OBSOLETE",".","Catalysis","of","the","second","transesterification","reaction","of","U12-type","spliceosomal","mRNA","splicing",".","Ligation","of","the","two","exons","occurs","via","a","transesterification","reaction","where","the","free","3","'","-hydroxyl","group","of","the","5","'","exon","is","the","nucleophile","attacking","the","3","'","splice","site",".","Non-expressed","sequences","are","now","detached","from","the","exons",".","In","cis","splicing",",","the","intron","is","in","a","lariat","structure",".","The","catalytic","site","is","thought","to","be","formed","by","U6","and/or","U2","snRNAs","and/or","associated","proteins","."),4362969). assertion_content_comment('oboGo_SecondU2Typespliceosomaltransesterificationactivity',s("OBSOLETE",".","Catalysis","of","the","second","transesterification","reaction","of","U2-type","spliceosomal","mRNA","splicing",".","Ligation","of","the","two","exons","occurs","via","a","transesterification","reaction","where","the","free","3","'","-hydroxyl","group","of","the","5","'","exon","is","the","nucleophile","attacking","the","3","'","splice","site",".","Non-expressed","sequences","are","now","detached","from","the","exons",".","In","cis","splicing",",","the","intron","is","in","a","lariat","structure",".","The","catalytic","site","is","thought","to","be","formed","by","U6","and/or","U2","snRNAs","and/or","associated","proteins","."),4362947). assertion_content_comment('oboGo_SecretinLikereceptoractivity',s("OBSOLETE",".","A","G-protein","coupled","receptor","that","is","structurally/functionally","related","to","the","secretin","receptor","."),4383935). assertion_content_comment('oboGo_Sedoheptulose_7_Phosphate_D_Glyceraldehyde_3_PhosphateGlyceronetransferaseActivity',s("Catalysis","of","the","reaction",":","sedoheptulose","7-phosphate","+","D-glyceraldehyde","3-phosphate","=","D-erythrose","4-phosphate","+","D-fructose","6-phosphate","."),4199314). assertion_content_comment('oboGo_SedoheptuloseBisphosphataseactivity',s("Catalysis","of","the","reaction",":","sedoheptulose","1",",","7-bisphosphate","+","H2O","=","sedoheptulose","7-phosphate","+","phosphate","."),4264096). assertion_content_comment('oboGo_SeleniumContainingprostheticgroupbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","a","prosthetic","group","that","contains","selenium",",","as","in","the","selenium-dependent","molybdenum","hydroxylases",".","The","selenium","atom","in","the","prosthetic","group","is","required","for","enzymatic","function","but","is","labile","to","a","variety","of","treatments","."),4174810). assertion_content_comment('oboGo_SeleniumContainingprostheticgroupmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","a","prosthetic","group","that","contains","selenium",",","as","in","the","selenium-dependent","molybdenum","hydroxylases",".","The","selenium","atom","in","the","prosthetic","group","is","required","for","enzymatic","function","but","is","labile","to","a","variety","of","treatments","."),4174799). assertion_content_comment('oboGo_SemaphorinPlexinsignalingpathwayinvolvedinoutflowtractmorphogenesis',s("A","series","of","molecular","signals","generated","as","a","consequence","of","a","semaphorin","receptor","(","composed","of","a","plexin","and","a","neurophilin",")","binding","to","a","semaphorin","ligand","that","contributes","to","outflow","tract","morphogenesis","."),4129524). assertion_content_comment('oboGo_SemaphorinPlexinsignalingpathwayinvolvedinregulationofphotoreceptorcellaxonguidance',s("Any","semaphorin-plexin","signaling","pathway","that","is","involved","in","regulation","of","photoreceptor","cell","axon","guidance","."),4139828). assertion_content_comment('oboGo_SemaphorinPlexinsignalingpathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","a","semaphorin","receptor","(","composed","of","a","plexin","and","a","neurophilin",")","binding","to","a","semaphorin","ligand","."),4129520). assertion_content_comment('oboGo_SeMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","the","selenium","atom","of","an","acceptor","molecule","."),4183517). assertion_content_comment('oboGo_SenecionineNOxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADPH","+","O","(","2",")","+","senecionine","=","H","(","2",")","O","+","NADP","(","+",")","+","senecionine","N-oxide","."),4342069). assertion_content_comment('oboGo_SenescenceAssociatedvacuole',s("A","lytic","vacuole","that","is","maintained","at","acidic","pH","and","has","different","tonoplast","composition","compared","to","the","central","vacuole",".","Found","during","leaf","senescence","and","develops","in","the","peripheral","cytoplasm","of","cells","that","contain","chloroplast","."),4335213). assertion_content_comment('oboGo_SepTrna_CysTrnasynthaseactivity',s("Catalysis","of","the","reaction",":","O-phospho-L-seryl-tRNACys","+","sulfide","=","L-cysteinyl-tRNACys","+","phosphate","."),4327892). assertion_content_comment('oboGo_SequenceSpecificcorepromoterbindingrnapolymeraseiitranscriptionfactoractivityinvolvedinpreinitiationcomplexformation',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","in","an","RNA","polymerase","II","(","Pol","II",")","core","promoter",",","the","region","composed","of","the","transcription","start","site","and","binding","sites","for","transcription","factors","of","the","Pol","II","basal","transcription","machinery",",","in","order","to","promote","formation","of","the","transcriptional","preinitiation","complex","(","PIC",")",",","the","formation","of","which","is","a","prerequisite","for","transcription","from","the","RNA","polymerase","II","promoter","."),4355843). assertion_content_comment('oboGo_SequenceSpecificdnabindingbacterialTypernapolymerasetranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","in","order","to","modulate","transcription","by","bacterial-type","RNA","polymerase",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","a","protein","or","macromolecular","complex","."),4357989). assertion_content_comment('oboGo_SequenceSpecificdnabindingmitochondrialrnapolymerasetranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","in","order","to","modulate","transcription","by","mitochondrial","RNA","polymerase",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","a","protein","or","macromolecular","complex","."),4358257). assertion_content_comment('oboGo_SequenceSpecificdnabindingrnapolymeraseiiitranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","in","order","to","modulate","transcription","by","RNA","polymerase","III",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","a","protein","or","macromolecular","complex","."),4356485). assertion_content_comment('oboGo_SequenceSpecificdnabindingrnapolymeraseiitranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","in","order","to","modulate","transcription","by","RNA","polymerase","II",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","a","protein","or","macromolecular","complex","."),4192839). assertion_content_comment('oboGo_SequenceSpecificdnabindingrnapolymeraseitranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","in","order","to","modulate","transcription","by","RNA","polymerase","I",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","a","protein","or","macromolecular","complex","."),4357698). assertion_content_comment('oboGo_SequenceSpecificdnabindingrnapolymeraserecruitingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","and","recruiting","RNA","polymerase","to","the","DNA","in","order","to","form","the","preinitiation","complex","(","PIC",")"),4356781). assertion_content_comment('oboGo_SequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","DNA","of","a","specific","nucleotide","composition",",","e.g",".","GC-rich","DNA","binding",",","or","with","a","specific","sequence","motif","or","type","of","DNA","e.g",".","promotor","binding","or","rDNA","binding","."),4163863). assertion_content_comment('oboGo_SequenceSpecificdnabindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","DNA","sequence","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","a","protein","or","macromolecular","complex","."),4192837). assertion_content_comment('oboGo_SequenceSpecificdnabindingtranscriptionfactorrecruitingtranscriptionfactoractivity',s("The","function","of","binding","to","a","specific","DNA","sequence","and","recruiting","another","transcription","factor","to","the","DNA","in","order","to","modulate","transcription",".","The","recruited","factor","may","bind","DNA","directly",",","or","may","be","colocalized","via","protein-protein","interactions","."),4356475). assertion_content_comment('oboGo_SequenceSpecificenhancerbindingrnapolymeraseiitranscriptionfactoractivity',s("Functions","to","initiate","or","regulate","RNA","polymerase","II","transcription","by","binding","an","enhancer","region","of","DNA","."),4192841). assertion_content_comment('oboGo_SequenceSpecifictranscriptionregulatoryregiondnabindingrnapolymeraseiitranscriptionfactorrecruitingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","specific","sequence","of","DNA","that","is","part","of","a","regulatory","region","that","controls","transcription","of","that","section","of","the","DNA","by","RNA","polymerase","II","and","recruiting","another","transcription","factor","to","the","DNA","in","order","to","modulate","transcription","by","RNAP","II","."),4358446). assertion_content_comment('oboGo_SerGlyTrnaalahydrolaseactivity',s("Catalysis","of","the","hydrolysis","of","misacylated","Ser-tRNA","(","Ala",")","and","Gly-tRNA","(","Ala",")"),4328731). assertion_content_comment('oboGo_Serine2Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","L-serine","+","H2O","+","NAD","+","=","3-hydroxypyruvate","+","NH3","+","NADH","."),4264159). assertion_content_comment('oboGo_Serine3Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","L-serine","+","NADP","(","+",")","=","L-alpha-formylglycine","+","2","H","(","+",")","+","NADPH","."),4318776). assertion_content_comment('oboGo_SerineCPalmitoyltransferaseactivity',s("Catalysis","of","the","reaction",":","L-serine","+","H","(","+",")","+","palmitoyl-CoA","=","3-dehydrosphinganine","+","CO","(","2",")","+","CoA","."),4201526). assertion_content_comment('oboGo_SerineCPalmitoyltransferasecomplex',s("An","enzyme","complex","that","catalyzes","the","transfer","of","a","palmitoyl","on","to","serine",",","forming","3-dehydro-D-sphinganine","."),4269734). assertion_content_comment('oboGo_SerineEthanolaminephosphatephosphodiesteraseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","serine","phosphoethanolamine","=","H","(","+",")","+","phosphoethanolamine","+","serine","."),4368546). assertion_content_comment('oboGo_SerineGlyoxylatetransaminaseactivity',s("Catalysis","of","the","reaction",":","L-serine","+","glyoxylate","=","3-hydroxypyruvate","+","glycine","."),4264125). assertion_content_comment('oboGo_SerineIsocitratelyasepathway',s("A","one-carbon","metabolic","process","in","which","acetyl-CoA","is","produced","from","formaldehyde","and","carbon","dioxide","."),4240960). assertion_content_comment('oboGo_SerineOAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","L-serine","+","acetyl-CoA","=","O-acetyl-L-serine","+","CoA","."),4256378). assertion_content_comment('oboGo_SerineOAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","acyl","group","to","an","oxygen","atom","on","the","serine","molecule","."),4256375). assertion_content_comment('oboGo_SerinePhosphoethanolaminesynthaseactivity',s("Catalysis","of","the","reaction",":","L-serine","+","CDP-ethanolamine","=","L-serine-phosphoethanolamine","+","CMP","+","H","(","+",")"),4369281). assertion_content_comment('oboGo_SerinePyruvateaminotransferasecomplex',s("An","enzyme","complex","that","catalyzes","the","formation","of","hydroxypyruvate","and","alanine","from","serine","and","pyruvate","."),4221336). assertion_content_comment('oboGo_SerinePyruvatetransaminaseactivity',s("Catalysis","of","the","reaction",":","L-serine","+","pyruvate","=","3-hydroxypyruvate","+","L-alanine","."),4201544). assertion_content_comment('oboGo_SerineSulfateammoniaLyaseactivity',s("Catalysis","of","the","reaction",":","L-serine","O-sulfate","+","H2O","=","pyruvate","+","NH3","+","sulfate","."),4264147). assertion_content_comment('oboGo_SerineTrnaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","L-serine","+","tRNA","(","Ser",")","=","AMP","+","diphosphate","+","L-seryl-tRNA","(","Ser",")"),4199797). assertion_content_comment('oboGo_SerineTypeaminopeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","a","peptide","bond","not","more","than","three","residues","from","the","N-terminus","of","a","polypeptide","chain","by","a","catalytic","mechanism","that","involves","a","catalytic","triad","consisting","of","a","serine","nucleophile","that","is","activated","by","a","proton","relay","involving","an","acidic","residue","(","e.g",".","aspartate","or","glutamate",")","and","a","basic","residue","(","usually","histidine",")"),4180853). assertion_content_comment('oboGo_SerineTypecarboxypeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","a","peptide","bond","not","more","than","three","residues","from","the","C-terminus","of","a","polypeptide","chain","by","a","catalytic","mechanism","that","involves","a","catalytic","triad","consisting","of","a","serine","nucleophile","that","is","activated","by","a","proton","relay","involving","an","acidic","residue","(","e.g",".","aspartate","or","glutamate",")","and","a","basic","residue","(","usually","histidine",")"),4168605). assertion_content_comment('oboGo_SerineTypedAlaDAlacarboxypeptidaseactivity',s("Catalysis","of","the","reaction",":","(","Ac",")","2-L-Lys-D-alanyl-D-alanine","+","H2O","=","(","Ac",")","2-L-Lys-D-alanine","+","D-alanine","."),4256348). assertion_content_comment('oboGo_SerineTypeendopeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","internal",",","alpha-peptide","bonds","in","a","polypeptide","chain","by","a","catalytic","mechanism","that","involves","a","catalytic","triad","consisting","of","a","serine","nucleophile","that","is","activated","by","a","proton","relay","involving","an","acidic","residue","(","e.g",".","aspartate","or","glutamate",")","and","a","basic","residue","(","usually","histidine",")"),4187694). assertion_content_comment('oboGo_SerineTypeendopeptidaseinhibitoractivity',s("Stops",",","prevents","or","reduces","the","activity","of","serine-type","endopeptidases",",","enzymes","that","catalyze","the","hydrolysis","of","nonterminal","peptide","bonds","in","a","polypeptide","chain",";","a","serine","residue","(","and","a","histidine","residue",")","are","at","the","active","center","of","the","enzyme","."),4200355). assertion_content_comment('oboGo_SerineTypeexopeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","a","peptide","bond","not","more","than","three","residues","from","the","N-","or","C-terminus","of","a","polypeptide","chain","by","a","catalytic","mechanism","that","involves","a","catalytic","triad","consisting","of","a","serine","nucleophile","that","is","activated","by","a","proton","relay","involving","an","acidic","residue","(","e.g",".","aspartate","or","glutamate",")","and","a","basic","residue","(","usually","histidine",")"),4168603). assertion_content_comment('oboGo_SerineTypepeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","peptide","bonds","in","a","polypeptide","chain","by","a","catalytic","mechanism","that","involves","a","catalytic","triad","consisting","of","a","serine","nucleophile","that","is","activated","by","a","proton","relay","involving","an","acidic","residue","(","e.g",".","aspartate","or","glutamate",")","and","a","basic","residue","(","usually","histidine",")"),4168599). assertion_content_comment('oboGo_SerineTypeproXcarboxypeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","a","Pro-Xaa","bond","by","a","serine-type","peptidase","mechanism","to","release","a","C-terminal","amino","acid","."),4210511). assertion_content_comment('oboGo_SerineTypesignalpeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","a","signal","peptide","from","a","protein","precursor","by","a","serine","endopeptidase","mechanism","."),4248294). assertion_content_comment('oboGo_SerotoninActivatedcationSelectivechannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","cation","by","a","channel","that","opens","when","a","specific","extracellular","ligand","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts",",","and","that","is","activated","by","serotonin","."),4217944). assertion_content_comment('oboGo_SerotoninGatedcationchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","cation","by","a","channel","that","opens","when","serotonin","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4333090). assertion_content_comment('oboGo_SerTrnathrhydrolaseactivity',s("Catalysis","of","the","hydrolysis","of","misacylated","Ser-tRNA","(","Thr",")"),4328686). assertion_content_comment('oboGo_SerylTrnaaminoacylation',s("The","process","of","coupling","serine","to","seryl-tRNA",",","catalyzed","by","seryl-tRNA","synthetase",".","In","tRNA","aminoacylation",",","the","amino","acid","is","first","activated","by","linkage","to","AMP","and","then","transferred","to","either","the","2","'","-","or","the","3","'","-hydroxyl","group","of","the","3","'","-adenosine","residue","of","the","tRNA","."),4179526). assertion_content_comment('oboGo_SexDeterminationSomaticGonadalinteraction',s("The","process","that","mediates","the","interactions","between","somatic","cells","and","gonadal","cells","that","ultimately","results","in","the","specification","of","sexual","status","of","the","organism","."),4015959). assertion_content_comment('oboGo_SexSpecificpigmentation',s("Establishment","of","a","pattern","of","pigment","in","one","sex","that","is","not","observed","in","the","other","sex","."),4104204). assertion_content_comment('oboGo_SFormylglutathionehydrolaseactivity',s("Catalysis","of","the","reaction",":","S-formylglutathione","+","H","(","2",")","O","=","formate","+","glutathione","+","H","(","+",")"),4275049). assertion_content_comment('oboGo_SGlycosidebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","S-glycosides",",","any","compound","in","which","a","glycosyl","group","has","been","substituted","into","a","thiol","group","."),4029065). assertion_content_comment('oboGo_SGlycosidecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","S-glycosides",",","any","compound","in","which","a","glycosyl","group","has","been","substituted","into","a","thiol","group","."),4245484). assertion_content_comment('oboGo_SGlycosidemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","S-glycosides",",","any","compound","in","which","a","glycosyl","group","has","been","substituted","into","a","thiol","group","."),4029042). assertion_content_comment('oboGo_SH2DomainMediatedcomplexassembly',s("A","process","of","protein","complex","assembly","in","which","the","arrangement","and","bonding","together","of","the","set","of","components","that","form","the","protein","complex","is","mediated","by","an","SH2","domain","interaction","."),4172109). assertion_content_comment('oboGo_ShcEgfrcomplex',s("A","protein","complex","that","contains","the","epidermal","growth","factor","receptor","(","EGFR",")","and","the","adaptor","protein","Shc",",","and","is","involved","in","linking","EGFR","activation","to","the","p21-Ras","pathway","."),4175325). assertion_content_comment('oboGo_ShcGrb2Soscomplex',s("A","protein","complex","that","contains","Grb2",",","the","adaptor","protein","Shc","and","the","guanine","nucleotide","exchange","factor","Sos","(","or","an","ortholog","thereof",",","such","as","mSos1",")",",","and","is","involved","in","linking","EGFR","activation","to","the","p21-Ras","pathway","."),4177149). assertion_content_comment('oboGo_SheetFormingcollagen',s("Any","collagen","polymer","in","which","collagen","triple","helices","associate","to","form","sheet-like","networks","."),4007146). assertion_content_comment('oboGo_Shikimate5Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","shikimate","+","NADP","+","=","5-dehydroshikimate","+","NADPH","+","H","+"),4201673). assertion_content_comment('oboGo_ShikimateOHydroxycinnamoyltransferaseactivity',s("Catalysis","of","the","reaction",":","shikimate","+","coumaroyl-CoA","=","4-coumaroylshikimate","+","CoA","."),4366376). assertion_content_comment('oboGo_ShortBranchedChainAcylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","acceptor","=","2",",","3-dehydroacyl-CoA","+","reduced","acceptor",",","where","the","acyl","group","is","a","short","branched","chain","fatty","acid","residue","."),4301910). assertion_content_comment('oboGo_ShortChaincarboxylesteraseactivity',s("Catalysis","of","the","reaction",":","a","carboxylic","ester","+","H2O","=","an","alcohol","+","a","carboxylic","anion",",","where","the","carboxylic","chain","has","8","or","fewer","carbon","atoms","."),4246612). assertion_content_comment('oboGo_ShortChaincollagen',s("Any","assembly","of","collagen","in","which","the","collagen","chains","are","relatively","short","compared","to","the","fibrillar","collagens","."),4218067). assertion_content_comment('oboGo_ShortChainfattyacidbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fatty","acids","with","a","chain","length","of","less","than","8","carbons","."),4281204). assertion_content_comment('oboGo_ShortChainfattyacidcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","fatty","acids","with","a","chain","length","of","less","than","8","carbons","."),4243653). assertion_content_comment('oboGo_ShortChainfattyacidCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","a","short-chain","carboxylic","acid","+","CoA","=","AMP","+","diphosphate","+","an","acyl-CoA",";","short-chain","fatty","acids","have","chain","lengths","of","less","than","8","carbons","."),4320474). assertion_content_comment('oboGo_ShortChainfattyacidimport',s("The","directed","movement","of","short-chain","fatty","acids","into","a","cell","or","organelle",".","Short-chain","fatty","acids","are","fatty","acids","with","a","chain","length","of","less","than","8","carbons","."),4294476). assertion_content_comment('oboGo_ShortChainfattyacidmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","fatty","acids","with","a","chain","length","of","less","than","8","carbons","."),4243633). assertion_content_comment('oboGo_ShortChainfattyacidtransporteractivity',s("Enables","the","directed","movement","of","short-chain","fatty","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",".","Short-chain","fatty","acids","have","a","chain","length","of","less","than","8","carbons","."),4290408). assertion_content_comment('oboGo_ShortChainfattyacidtransport',s("The","directed","movement","of","short-chain","fatty","acids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Short-chain","fatty","acids","are","fatty","acids","with","a","chain","length","of","less","than","8","carbons","."),4294364). assertion_content_comment('oboGo_ShortChainfattyaciduptaketransporteractivity',s("Enables","the","directed","movement","of","short-chain","fatty","acids","into","a","cell","or","organelle",".","Short-chain","fatty","acids","have","a","chain","length","of","less","than","8","carbons","."),4290417). assertion_content_comment('oboGo_ShortDayphotoperiodismflowering',s("A","change","from","vegetative","to","reproductive","phase","as","a","result","of","detection","of",",","or","exposure","to",",","a","period","of","light","that","falls","short","of","the","critical","day","length",".","The","critical","day","length","varies","between","species",".","Although","the","term","is","short-day","is","used",",","most","species","actually","respond","to","the","duration","of","the","night",",","so","that","the","response","will","occur","when","a","period","of","darkness","exceeds","the","number","of","hours","defined","by","24","minus","the","critical","day","length","."),4106248). assertion_content_comment('oboGo_ShortDayphotoperiodism',s("A","change","in","state","or","activity","of","the","organism","(","in","terms","of","movement",",","secretion",",","enzyme","production",",","gene","expression",",","etc.",")","as","a","result","of","detection","of",",","or","exposure","to",",","a","day","length","that","falls","short","of","a","particular","duration","known","as","the","'","critical","day","length","'","The","critical","day","length","varies","between","species",".","Although","the","term","short-day","is","used",",","most","species","actually","respond","to","the","duration","of","the","night",",","so","that","the","response","will","occur","when","a","period","of","darkness","exceeds","the","number","of","hours","defined","by","24","hours","minus","the","critical","day","length","."),4106241). assertion_content_comment('oboGo_ShortTermmemory',s("The","memory","process","that","deals","with","the","storage",",","retrieval","and","modification","of","information","received","a","short","time","(","up","to","about","30","minutes",")","ago",".","This","type","of","memory","is","typically","dependent","on","direct",",","transient","effects","of","second","messenger","activation","."),4234943). assertion_content_comment('oboGo_ShortWaveSensitiveopsin',s("OBSOLETE",".","An","opsin","with","maximal","absorption","between","400","and","500","nm","."),4302757). assertion_content_comment('oboGo_SHydroxymethylglutathionedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","S-","(","hydroxymethyl",")","glutathione","+","NAD","(","P",")","+","=","S-formylglutathione","+","NAD","(","P",")","H","+","H","+"),4183361). assertion_content_comment('oboGo_SHydroxymethylglutathionesynthaseactivity',s("Catalysis","of","the","reaction",":","S-","(","hydroxymethyl",")","glutathione","=","formaldehyde","+","glutathione","."),4183235). assertion_content_comment('oboGo_SialateOAcetylesteraseactivity',s("Catalysis","of","the","reaction",":","N-acetyl-O-acetylneuraminate","(","free","or","glycosidically","bound",")","+","H2O","=","N-acetylneuraminate","+","acetate","."),4383751). assertion_content_comment('oboGo_Sid2Mob1complex',s("A","protein","complex","that","contains","a","protein","kinase","(","Sid2","in","S",".","pombe",")","and","its","regulatory","subunit","(","Mob1",")","The","Sid2p-Mob1p","kinase","complex","is","a","component","of","the","septation","initiation","network","in","fission","yeast","(","called","the","mitotic","exit","network","in","S",".","cerevisiae",")","and","is","required","for","cytokinesis",".","The","analogous","complex","in","S",".","cerevisiae","is","called","Dbf2p-Mob1p","complex","."),4348617). assertion_content_comment('oboGo_SignalRecognitionParticlegtpaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","GTP","+","H2O","=","GDP","+","phosphate",".","Activity","is","associated","with","the","signal-recognition","particle",",","a","protein","and","RNA-containing","structure","involved","in","endoplasmic","reticulum-associated","protein","synthesis","."),4252656). assertion_content_comment('oboGo_SignalTransductionInvolvedInIntraSdnadamagecheckpoint',s("A","signal","transduction","process","that","contributes","to","an","intra-S","DNA","damage","checkpoint","."),4128260). assertion_content_comment('oboGo_SignalTransductionInvolvedInSMcheckpoint',s("A","signal","transduction","process","that","contributes","to","an","S-M","checkpoint","."),4127932). assertion_content_comment('oboGo_SignalTransductionViaACisPhosphorylationevent',s("The","process","in","which","a","signal","is","conveyed","via","the","transfer","of","one","or","more","phosphate","groups","by","a","kinase","to","a","residue","in","the","same","kinase","molecule","."),4347064). assertion_content_comment('oboGo_SignalTransductionViaATransPhosphorylationevent',s("The","process","in","which","a","signal","is","conveyed","via","the","transfer","of","one","or","more","phosphate","groups","by","a","kinase","to","a","residue","in","a","different","molecule","."),4347075). assertion_content_comment('oboGo_SilverExportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","Ag","+","(","in",")","=","ADP","+","phosphate","+","Ag","+","(","out",")"),4292080). assertion_content_comment('oboGo_Sin3Typecomplex',s("Any","of","a","number","of","evolutionarily","conserved","histone","deacetylase","complexes","(","HDACs",")","containing","a","core","consisting","of","a","paired","amphipathic","helix","motif","protein","(","e.g",".","Sin3p","in","S",".","cerevisiae",",","Pst1","in","S",".","pombe","or","Sin3A","in","mammals",")","at","least","one","class","I","histone","deacetylase","(","e.g",".","Rpd3p","in","S",".","cerevisiae",",","Clr6","in","S",".","pombe",",","or","HDAC1","and","HDAC2","in","mammals",")",",","and","at","least","one","WD40","repeat","protein","(","e.g",".","Ume1p","in","S",".","cerevisiae",",","Prw1","in","S",".","pombe",",","or","RbAp46","and","RbAp48","in","mammals",")","These","complexes","also","contain","a","variable","number","of","other","proteins","that","direct","histone","binding",",","DNA","binding",",","or","add","other","functionality","to","the","complex","."),4132595). assertion_content_comment('oboGo_Sinapate1Glucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","sinapate","=","UDP","+","1-sinapoyl-D-glucose","."),4264182). assertion_content_comment('oboGo_SinapoylglucoseCholineoSinapoyltransferaseactivity',s("Catalysis","of","the","reaction",":","1-O-sinapoyl-beta-D-glucose","+","choline","=","O-sinapoylcholine","+","D-glucose","."),4367728). assertion_content_comment('oboGo_SinapoylglucoseMalateoSinapoyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-malate","+","1-O-sinapoyl-beta-D-glucose","=","D-glucose","+","sinapoyl","(","S",")","-malate","."),4301299). assertion_content_comment('oboGo_SinapoylglucoseSinapoylglucoseoSinapoyltransferaseactivity',s("Catalysis","of","the","reaction",":","2","1-O-sinapoyl-beta-D-glucose","=","1",",","2-di-O-sinapoyl-beta-D-glucose","+","D-glucose","."),4365294). assertion_content_comment('oboGo_SinapoylSpermidine_SinapoylCoANAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","sinapoyl","group","to","a","nitrogen","atom","on","the","spermidine","molecule","."),4182538). assertion_content_comment('oboGo_SingleSpeciesbiofilmformationinoronhostorganism',s("A","process","in","which","microorganisms","of","the","same","species","attach","to","and","grow","in","or","on","a","surface","in","a","host","species",",","and","produce","extracellular","polymers","that","facilitate","attachment","and","matrix","formation",",","resulting","in","an","alteration","in","the","phenotype","of","the","organisms","with","respect","to","growth","rate","and","gene","transcription",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4095237). assertion_content_comment('oboGo_SingleSpeciesbiofilmformationoninanimatesubstrate',s("A","process","in","which","microorganisms","of","the","same","species","attach","to","and","grow","on","an","inanimate","surface","such","as","a","rock","or","pipe",",","and","produce","extracellular","polymers","that","facilitate","attachment","and","matrix","formation",",","resulting","in","an","alteration","in","the","phenotype","of","the","organisms","with","respect","to","growth","rate","and","gene","transcription","."),4289134). assertion_content_comment('oboGo_SingleSpeciesbiofilmformation',s("A","process","in","which","microorganisms","of","the","same","species","attach","to","and","grow","on","a","surface","such",",","and","produce","extracellular","polymers","that","facilitate","attachment","and","matrix","formation",",","resulting","in","an","alteration","in","the","phenotype","of","the","organisms","with","respect","to","growth","rate","and","gene","transcription","."),4095234). assertion_content_comment('oboGo_Single_StrandedDNABinding_4',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4222474). assertion_content_comment('oboGo_SingleStrandeddnabinding',s("Interacting","selectively","and","non-covalently","with","single-stranded","DNA","."),4193374). assertion_content_comment('oboGo_SingleStrandeddnaDependentatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",";","this","reaction","requires","the","presence","of","single-stranded","DNA",",","and","it","drives","another","reaction","."),4267395). assertion_content_comment('oboGo_SingleStrandeddnaDependentatpDependentdnahelicaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",",","in","the","presence","of","single-stranded","DNA",";","drives","the","unwinding","of","a","DNA","helix","."),4267398). assertion_content_comment('oboGo_SingleStrandeddnaDependentatpDependentdnahelicasecomplex',s("A","protein","complex","that","possesses","single-stranded","DNA-dependent","DNA","helicase","activity","."),4267418). assertion_content_comment('oboGo_Single_StrandedDNASpecific3_5ExodeoxyribonucleaseActivity',s("Catalysis","of","the","sequential","cleavage","of","mononucleotides","from","a","free","3","'","terminus","of","a","single-stranded","DNA","molecule","."),4255432). assertion_content_comment('oboGo_Single_StrandedDNASpecific5_3ExodeoxyribonucleaseActivity',s("Catalysis","of","the","sequential","cleavage","of","nucleotides","(","such","as","mononucleotides","or","dinucleotides",")","from","a","free","5","'","terminus","of","a","single-stranded","DNA","molecule","."),4300036). assertion_content_comment('oboGo_SingleStrandeddnaspecificendodeoxyribonucleaseactivity',s("Catalysis","of","the","hydrolysis","of","ester","linkages","within","a","single-stranded","deoxyribonucleic","acid","molecule","by","creating","internal","breaks","."),4345322). assertion_content_comment('oboGo_SingleStrandeddnaspecificexodeoxyribonucleaseactivity',s("Catalysis","of","the","sequential","cleavage","of","mononucleotides","from","a","free","5","'","or","3","'","terminus","of","a","single-stranded","DNA","molecule","."),4255429). assertion_content_comment('oboGo_SingleStrandedrnabinding',s("Interacting","selectively","and","non-covalently","with","single-stranded","RNA","."),4176693). assertion_content_comment('oboGo_SingleStrandedtelomericdnabinding',s("Interacting","selectively","and","non-covalently","with","single-stranded","telomere-associated","DNA","."),4317967). assertion_content_comment('oboGo_SingleStrandselectiveuracildnanGlycosylaseactivity',s("Catalysis","of","the","cleavage","of","the","N-C1","'","glycosidic","bond","between","the","damaged","DNA","base","and","the","deoxyribose","sugar",",","releasing","a","free","base","and","leaving","an","apyrimidinic","(","AP",")","site",".","Enzymes","with","this","activity","recognize","and","remove","uracil","bases","present","in","single-stranded","DNA","."),4269581). assertion_content_comment('oboGo_SingleSubunittypernapolymerasebinding',s("Interacting","selectively","and","non-covalently","with","a","single","subunit","RNA","polymerase","enzyme",",","which","is","composed","of","a","single","catalytic","subunit","similar","to","the","RNA","polymerase","enzymes","from","phages","T3",",","T7",",","and","SP6","."),4356097). assertion_content_comment('oboGo_SingletOxygenMediatedprogrammedcelldeath',s("Programmed","cell","death","induced","by","singlet","oxygen",".","Programmed","cell","death","is","the","cell","death","resulting","from","activation","of","endogenous","cellular","processes","."),4332031). assertion_content_comment('oboGo_SiteSpecificdnaMethyltransferaseadenineSpecificactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","DNA","adenine","=","S-adenosyl-L-homocysteine","+","DNA","6-methylaminopurine","."),4256407). assertion_content_comment('oboGo_SiteSpecificdnaMethyltransferasecytosineN4Specificactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","DNA","cytosine","=","S-adenosyl-L-homocysteine","+","DNA","N4-methylcytosine","."),4290285). assertion_content_comment('oboGo_SiteSpecificdnareplicationterminationatrts1barrier',s("A","DNA","replication","termination","process","that","takes","place","at","the","RTS1","termination","site","in","the","mating","type","locus",",","in","a","specific","direction","required","for","subsequent","imprinting","and","mating-type","switching","."),4128822). assertion_content_comment('oboGo_SiteSpecificdnareplicationtermination',s("A","DNA","replication","termination","process","that","takes","place","at","a","specific","termination","site","."),4128819). assertion_content_comment('oboGo_SiteSpecificendodeoxyribonucleaseactivityspecificforalteredbase',s("Catalysis","of","the","hydrolysis","of","ester","linkages","at","specific","sites","within","a","deoxyribonucleic","acid","molecule","by","creating","internal","breaks","."),4301864). assertion_content_comment('oboGo_SiteSpecificrecombinaseactivity',s("Catalysis","of","the","formation","of","new","phosphodiester","bonds","between","a","pair","of","short",",","unique","DNA","target","sequences","."),4256526). assertion_content_comment('oboGo_SiteSpecifictelomereresolvaseactivity',s("Catalysis","of","a","site-specific","breakage","and","reunion","reaction","that","generates","two","hairpin","telomeres","from","a","replicated","telomere","substrate",".","Occurs","via","a","two-step","transesterification","with","a","protein-DNA","intermediate","similar","to","that","used","by","topoisomerases","and","site-specific","recombinases","."),4318272). assertion_content_comment('oboGo_Skp1ProteinHydroxyprolinenAcetylglucosaminyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetylglucosamine","+","Skp1-protein-hydroxyproline","=","UDP","+","Skp1-protein-O-","(","N-acetyl-D-glucosaminyl",")","hydroxyproline","."),4343125). assertion_content_comment('oboGo_SLactaldehydereductaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-propane-1",",","2-diol","+","NAD","+","=","(","S",")","-lactaldehyde","+","NADH","+","H","+"),4192024). assertion_content_comment('oboGo_SLactate2Kinaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-lactate","+","GTP","=","2-phospho-","(","S",")","-lactate","+","GDP","."),4327243). assertion_content_comment('oboGo_SLayerorganization',s("A","process","that","is","carried","out","at","the","cellular","level","which","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","an","S-layer","enveloping","the","cell",".","The","S-layer","is","a","crystalline","protein","layer","surrounding","some","bacteria","."),4298863). assertion_content_comment('oboGo_SLayer',s("A","crystalline","protein","layer","surrounding","some","bacteria","."),4311053). assertion_content_comment('oboGo_SLIKSAGALikecomplex',s("A","SAGA-type","histone","acetyltransferase","complex","that","contains","Rtg2","and","a","smaller","form","of","Spt7","than","the","fungal","SAGA","complex",",","and","lacks","Spt8",".","The","complex","is","involved","in","the","yeast","retrograde","response","pathway",",","which","is","important","for","gene","expression","changes","during","mitochondrial","dysfunction","."),4359564). assertion_content_comment('oboGo_SLimonene12Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","(","-",")","-","(","4S",")","-limonene","+","NAD","(","P",")","H","+","H","+","+","O2","=","NAD","(","P",")","+","+","H2O","+","(","4S",")","-limonene-1",",","2-epoxide","."),4191028). assertion_content_comment('oboGo_SLimonene3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","(","4S",")","-limonene","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","(","1S",",","6R",")","-isopiperitenol","+","H","(","2",")","O","+","NADP","(","+",")"),4276362). assertion_content_comment('oboGo_SLimonene6Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","(","-",")","-limonene","+","NADPH","+","H","+","+","O2","=","(","-",")","-trans-carveol","+","NADP","+","+","H2O","."),4276376). assertion_content_comment('oboGo_SLimonene7Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","(","4S",")","-limonene","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","(","4S",")","-perillyl","alcohol","+","H","(","2",")","O","+","NADP","(","+",")"),4276390). assertion_content_comment('oboGo_SLinaloolsynthaseactivity',s("Catalysis","of","the","reaction",":","geranyl","diphosphate","+","H","(","2",")","O","=","(","S",")","-linalool","+","diphosphate","."),4360594). assertion_content_comment('oboGo_SlitRobosignalingcomplex',s("A","protein-carbohydrate","complex","that","consists","of","a","transmembrane","roundabout","(","Robo",")","receptor",",","an","extracellular","Slit","ligand","and","heparin/heparan","sulfate","."),4172348). assertion_content_comment('oboGo_SlowTwitchskeletalmusclefibercontraction',s("A","process","in","which","force","is","generated","within","slow-twitch","skeletal","muscle","tissue",",","resulting","in","a","change","in","muscle","geometry",".","Force","generation","involves","a","chemo-mechanical","energy","conversion","step","that","is","carried","out","by","the","actin/myosin","complex","activity",",","which","generates","force","through","ATP","hydrolysis",".","The","slow-twitch","skeletal","muscle","is","characterized","by","slow","time","parameters",",","low","force","development","and","resistance","to","fatigue","."),4058306). assertion_content_comment('oboGo_Slx1Slx4complex',s("A","heterodimeric","protein","complex","that","possesses","an","endonuclease","activity","that","specifically","cleaves","certain","types","of","branched","DNA","structures",";","because","such","structures","often","form","during","the","replication","ribosomal","DNA","(","rDNA",")","repeats",",","the","complex","plays","a","role","in","the","maintenance","of","rDNA",".","The","subunits","are","known","as","Slx1","and","Slx","4","in","budding","and","fission","yeasts",",","and","are","conserved","in","eukaryotes","."),4341169). assertion_content_comment('oboGo_SMAD2Smad3proteincomplex',s("A","heteromeric","SMAD","protein","complex","that","contains","SMAD2","and","SMAD3","."),4164852). assertion_content_comment('oboGo_SMAD2Smad4proteincomplex',s("A","heteromeric","SMAD","protein","complex","that","contains","SMAD2","and","SMAD4","."),4164862). assertion_content_comment('oboGo_SMAD3Smad4proteincomplex',s("A","heteromeric","SMAD","protein","complex","that","contains","SMAD3","and","SMAD4","."),4164832). assertion_content_comment('oboGo_SmallConductanceCalciumActivatedpotassiumchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","potassium","by","a","channel","with","a","unit","conductance","of","2","to","20","picoSiemens","that","opens","in","response","to","stimulus","by","internal","calcium","ions",".","Small","conductance","calcium-activated","potassium","channels","are","more","sensitive","to","calcium","than","are","large","conductance","calcium-activated","potassium","channels",".","Transport","by","a","channel","involves","catalysis","of","facilitated","diffusion","of","a","solute","(","by","an","energy-independent","process",")","involving","passage","through","a","transmembrane","aqueous","pore","or","channel",",","without","evidence","for","a","carrier-mediated","mechanism","."),4304531). assertion_content_comment('oboGo_SmallConjugatingProteinSpecificendopeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","peptide","bonds","between","an","alpha-carboxyl","group","and","an","alpha-amino","group","within","a","small","protein","such","as","ubiquitin","or","a","ubiquitin-like","protein","(","e.g",".","APG8",",","ISG15",",","NEDD8",",","SUMO",")"),4179634). assertion_content_comment('oboGo_SmallConjugatingProteinSpecificisopeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","an","isopeptide","bond","between","a","small","protein","such","as","ubiquitin","or","a","ubiquitin-like","protein","(","e.g",".","APG8",",","ISG15",",","NEDD8",",","SUMO",")","and","a","protein","to","which","the","small","protein","has","been","conjugated","."),4179587). assertion_content_comment('oboGo_SmallConjugatingProteinSpecificproteaseactivity',s("Catalysis","of","the","hydrolysis","of","peptide","or","isopeptide","bonds","within","small","proteins","such","as","ubiquitin","or","ubiquitin-like","proteins","(","e.g",".","APG8",",","ISG15",",","NEDD8",",","SUMO",")",",","or","between","the","small","protein","and","a","larger","protein","to","which","it","has","been","conjugated","."),4171257). assertion_content_comment('oboGo_SmallMoleculecarrierortransporter',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4219551). assertion_content_comment('oboGo_SmallNucleolarRNA_1',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4219846). assertion_content_comment('oboGo_SmallSubunitprocessomeassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","proteins","and","RNA","molecules","to","form","a","small-subunit","processome","."),4074983). assertion_content_comment('oboGo_SmallSubunitprocessome',s("A","large","ribonucleoprotein","complex","that","is","an","early","preribosomal","complex",".","In","S",".","cerevisiae",",","it","has","a","size","of","80S","and","consists","of","the","35S","pre-rRNA",",","early-associating","ribosomal","proteins","most","of","which","are","part","of","the","small","ribosomal","subunit",",","the","U3","snoRNA","and","associated","proteins","."),4330207). assertion_content_comment('oboGo_SMalonyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","malonyl","group","to","a","sulfur","atom","on","the","acceptor","molecule","."),4208786). assertion_content_comment('oboGo_SMandelatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-2-hydroxy-2-phenylacetate","+","acceptor","=","2-oxo-2-phenylacetate","+","reduced","acceptor","."),4341891). assertion_content_comment('oboGo_Smc5Smc6complex',s("A","conserved","complex","that","contains","a","heterodimer","of","SMC","proteins","(","Smc5p","and","Smc6p",",","or","homologs","thereof",")","and","several","other","proteins",",","and","is","involved","in","DNA","repair","and","maintaining","cell","cycle","arrest","following","DNA","damage",".","In","S",".","cerevisiae",",","this","is","an","octameric","complex","called","Mms21-Smc5-Smc6","complex",",","with","at","least","five","of","its","subunits","conserved","in","fission","yeast","and","humans","."),4061431). assertion_content_comment('oboGo_SMcheckpoint',s("A","cell","cycle","checkpoint","which","halts","replication","in","response","to","nucleotide","depletion","."),4127810). assertion_content_comment('oboGo_SmDContainingsmnSmproteincomplex',s("An","SMN-Sm","protein","complex","formed","by","the","association","of","the","methylated","Sm","proteins","B/B","'",",","D1",",","D2",",","D3",",","E",",","F",",","and","G","with","the","SMN","complex","."),4349265). assertion_content_comment('oboGo_S_Methyl_5_ThioadenosinePhosphorylaseActivity',s("Catalysis","of","the","reaction",":","5","'","-methylthioadenosine","+","phosphate","=","adenine","+","5-methylthio-D-ribose","1-phosphate","."),4269513). assertion_content_comment('oboGo_S_Methyl_5_Thioribose_1_PhosphateIsomeraseActivity',s("Catalysis","of","the","reaction",":","S-methyl-5-thio-alpha-D-ribose","1-phosphate","=","S-methyl-5-thio-D-ribulose","1-phosphate","."),4359181). assertion_content_comment('oboGo_S_Methyl_5_ThioriboseKinaseActivity',s("Catalysis","of","the","reaction",":","S-methyl-5-thio-D-ribose","+","ATP","=","S-methyl-5-thio-alpha-D-ribose","1-phosphate","+","ADP","+","2","H","(","+",")"),4359202). assertion_content_comment('oboGo_SMethylmalonylCoahydrolaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-methylmalonyl-CoA","+","H","(","2",")","O","=","CoA","+","H","(","+",")","+","methylmalonate","."),4371646). assertion_content_comment('oboGo_SMethylmethioninebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","S-methyl-methionine","(","SMM",")","from","methionine","and","S-adenosyl-methionine","(","Ado-Met",")",",","catalyzed","by","methionine","S-methyltransferase","(","MMT",")","SMM","can","be","reconverted","to","methionine","by","donating","a","methyl","group","to","homocysteine",",","and","concurrent","operation","of","this","reaction","and","that","mediated","by","MMT","sets","up","the","SMM","cycle","."),4335430). assertion_content_comment('oboGo_SMethylmethioninecycle',s("A","cyclic","series","of","interconversions","involving","S-methyl-L-methionine",",","S-adenosyl-L-homocysteine",",","S-adenosyl-L-methionine",",","L-homocysteine",",","and","L-methionine",".","Converts","the","methionine","group","of","adenosylmethionine","back","to","free","methionine",",","and","may","serve","regulate","the","cellular","adenosylmethionine","level","."),4340837). assertion_content_comment('oboGo_SMethylmethioninemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","S-methyl-methionine","(","SMM",")","SMM","can","be","converted","to","methionine","by","donating","a","methyl","group","to","homocysteine",",","and","concurrent","operation","of","this","reaction","and","that","mediated","by","MMT","sets","up","the","SMM","cycle","."),4335425). assertion_content_comment('oboGo_SMethylmethioninetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","S-methylmethionine","from","one","side","of","a","membrane","to","the","other","."),4345875). assertion_content_comment('oboGo_SMethylmethioninetransport',s("The","directed","movement","of","S-methylmethionine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4293720). assertion_content_comment('oboGo_SMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","to","the","sulfur","atom","of","an","acceptor","molecule","."),4184021). assertion_content_comment('oboGo_SMNGemin2complex',s("A","protein","complex","that","contains","the","survival","motor","neuron","(","SMN",")","protein","and","Gemin2",";","may","form","the","stable","core","of","the","larger","SMN","complex","."),4349150). assertion_content_comment('oboGo_SMNSmproteincomplex',s("A","protein","complex","formed","by","the","association","of","several","methylated","Sm","proteins","with","the","SMN","complex",";","the","latter","contains","the","survival","motor","neuron","(","SMN",")","protein","and","at","least","eight","additional","integral","components",",","including","the","Gemin2-8","and","unrip","proteins",";","additional","proteins",",","including","galectin-1","and","galectin-3",",","are","also","found","in","the","SMN-SM","complex",".","The","SMN-Sm","complex","is","involved","in","spliceosomal","snRNP","assembly","in","the","cytoplasm","."),4349161). assertion_content_comment('oboGo_SmoothMuscleCellMatrixadhesion',s("The","binding","of","a","smooth","muscle","cell","to","the","extracellular","matrix","via","adhesion","molecules","."),4138445). assertion_content_comment('oboGo_SMT3Dependentproteincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds",",","initiated","by","covalent","attachment","of","the","ubiquitin-like","protein","SMT3","to","the","target","protein","."),4042107). assertion_content_comment('oboGo_Smt3Proteinconjugation',s("The","covalent","addition","to","a","protein","of","Smt3",",","a","ubiquitin-like","protein","."),4042121). assertion_content_comment('oboGo_S_N_Acetyl_1_PhenylethylamineHydrolaseActivity',s("Catalysis","of","the","reaction",":","N-acetylphenylethylamine","+","H","(","2",")","O","=","acetate","+","phenylethylamine","."),4268580). assertion_content_comment('oboGo_Sn_Glycerol_3_Phosphate1_GalactosyltransferaseActivity',s("Catalysis","of","the","reaction",":","sn-glycerol","3-phosphate","+","UDP-D-galactose","=","1-O-alpha-D-galactosyl-sn-glycerol","3-phosphate","+","H","(","+",")","+","UDP","."),4367538). assertion_content_comment('oboGo_Sn_Glycerol_3_Phosphate2_Alpha_GalactosyltransferaseActivity',s("Catalysis","of","the","reaction",":","sn-glycerol","3-phosphate","+","UDP-D-galactose","=","2-","(","alpha-D-galactosyl",")","-sn-glycerol","3-phosphate","+","H","(","+",")","+","UDP","."),4366573). assertion_content_comment('oboGo_Sn_Glycerol_3_Phosphate_Ubiquinone_8OxidoreductaseActivity',s("Catalysis","of","the","reaction",":","sn-glycerol","3-phosphate","+","ubiquinone-8","=","glycerone","phosphate","+","ubiquinol-8","."),4186621). assertion_content_comment('oboGo_Sn_Glycerol_3_Phosphate_UbiquinoneOxidoreductaseActivity',s("Catalysis","of","the","reaction",":","sn-glycerol","3-phosphate","+","a","ubiquinone","=","glycerone","phosphate","+","a","ubiquinol","."),4186619). assertion_content_comment('oboGo_SNitrosoglutathionebinding',s("Interacting","selectively","and","non-covalently","with","S-nitrosoglutathione",",","a","nitrosothiol","considered","to","be","a","natural","nitric","oxide","(","NO",")","donor","involved","in","S-nitrosylation",",","and","in","the","storage","and","transport","of","nitric","oxide","in","biological","systems","."),4380835). assertion_content_comment('oboGo_SNitrosoglutathionereductaseactivity',s("Catalysis","of","the","reaction",":","glutathione","N-hydroxysulfenamide","+","NADH","+","H","+","=","S-nitrosoglutathione","+","NAD","+"),4182979). assertion_content_comment('oboGo_SNorcoclaurinesynthaseactivity',s("Catalysis","of","the","reaction",":","4-","(","2-aminoethyl",")","benzene-1",",","2-diol","+","4-hydroxyphenylacetaldehyde","=","(","S",")","-norcoclaurine","+","H2O","."),4266147). assertion_content_comment('oboGo_SnoRNA3Endcleavage',s("The","endonucleolytic","cleavage","of","snoRNA","3","'","ends",",","which","is","required","for","mature","snoRNAs","to","be","functional","."),4317535). assertion_content_comment('oboGo_SnoRNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","a","snoRNA","molecule","."),4167142). assertion_content_comment('oboGo_SnoRNAGuidedRRNA2OMethylation',s("The","posttranscriptional","addition","of","methyl","groups","to","the","2","'","-oxygen","atom","of","nucleotide","residues","in","an","rRNA","molecule","during","ribosome","biogenesis","using","a","snoRNA","guide","that","targets","the","position","of","methylation","."),4362491). assertion_content_comment('oboGo_SnRNA2ORibosemethylationguideactivity',s("Activity","that","provides","specificity","to","a","methylase","by","using","base","complementarity","to","guide","site-specific","2","'","-O-ribose","methylations","to","a","small","nuclear","RNA","molecule","."),4310601). assertion_content_comment('oboGo_SnRNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","an","snRNA","molecule","."),4357567). assertion_content_comment('oboGo_SnRNAActivatingproteincomplex',s("A","protein","complex","that","recognizes","the","proximal","sequence","element","of","RNA","polymerase","II","and","III","snRNA","promoters","."),4237853). assertion_content_comment('oboGo_SnRNAContainingribonucleoproteincomplexexportfromnucleus',s("The","directed","movement","of","a","ribonucleoprotein","complex","that","contains","small","nuclear","RNA","from","the","nucleus","to","the","cytoplasm","."),4164252). assertion_content_comment('oboGo_SnRNAStemLoopbinding',s("Interacting","selectively","and","non-covalently","with","a","stem-loop","in","a","small","nuclear","RNA","(","snRNA",")","An","RNA","stem-loop","is","a","secondary","RNA","structure","consisting","of","a","double-stranded","RNA","(","dsRNA",")","stem","and","a","terminal","loop","."),4379610). assertion_content_comment('oboGo_SOD1_Bcl_2Complex',s("A","heterodimeric","protein","complex","formed","of","superoxide","dismutase","1","and","Bcl-2",".","Complex","formation","is","thought","to","link","superoxide","dismutase","to","an","apoptotic","pathway","."),4341642). assertion_content_comment('oboGo_SOD1Calcineurincomplex',s("A","protein","complex","formed","by","the","association","of","superoxide","dismutase","1","(","SOD1",")","with","calcineurin",";","complex","formation","is","implicated","in","activation","of","calcineurin","by","SOD1","."),4331553). assertion_content_comment('oboGo_SodiumDependentlAscorbatetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","L-ascorbate","(","out",")","+","Na","+","(","out",")","=","L-ascorbate","(","in",")","+","Na","+","(","in",")"),4178521). assertion_content_comment('oboGo_SodiumDependentmultivitamintransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","multivitamin","(","out",")","+","Na","+","(","out",")","=","multivitamin","(","in",")","+","Na","+","(","in",")","Multivitamins","include","pantothenate",",","biotin","and","lipoate","."),4254986). assertion_content_comment('oboGo_SodiumDependentorganicaniontransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","organic","anions","from","one","side","of","a","membrane","to","the","other",",","in","a","sodium","dependent","manner","."),4318437). assertion_content_comment('oboGo_SodiumDependentorganicaniontransport',s("The","directed",",","sodium-dependent",",","movement","of","organic","anions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4318419). assertion_content_comment('oboGo_SodiumDependentorganiccationtransport',s("The","directed",",","sodium-dependent",",","movement","of","organic","cations","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4176757). assertion_content_comment('oboGo_SodiumDependentphosphatetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","phosphate","(","PO4","3-",")","ions","from","one","side","of","a","membrane","to","the","other",",","requiring","sodium","ions","."),4296459). assertion_content_comment('oboGo_SodiumDependentphosphatetransport',s("The","directed","movement","of","phosphate","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",",","by","a","mechanism","dependent","upon","sodium","ions","."),4137920). assertion_content_comment('oboGo_SodiumExportingatpaseactivityphosphorylativemechanism',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","Na","+","(","in",")","=","ADP","+","phosphate","+","Na","+","(","out",")",";","by","a","phosphorylative","mechanism","."),4252923). assertion_content_comment('oboGo_SodiumIndependenticosanoidtransport',s("The","directed",",","sodium-independent",",","movement","of","icosanoids","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Icosanoids","are","unsaturated","C20","fatty","acids","and","skeletally","related","compounds","."),4170037). assertion_content_comment('oboGo_SodiumIndependentleukotrienetransport',s("The","directed",",","sodium-independent",",","movement","of","leukotrienes","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","Leukotrienes","are","linear","C20","endogenous","metabolites","of","arachidonic","acid","(","icosa-5",",","8",",","11",",","14-tetraenoic","acid",")","containing","a","terminal","carboxy","function","and","four","or","more","double","bonds","(","three","or","more","of","which","are","conjugated",")","as","well","as","other","functional","groups","."),4170169). assertion_content_comment('oboGo_SodiumIndependentorganicaniontransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","organic","anions","from","one","side","of","a","membrane","to","the","other",",","in","a","sodium","independent","manner","."),4296179). assertion_content_comment('oboGo_SodiumIndependentorganicaniontransport',s("The","directed",",","sodium-independent",",","movement","of","organic","anions","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4318428). assertion_content_comment('oboGo_SodiumIndependentprostaglandintransport',s("The","directed",",","sodium-independent",",","movement","of","prostaglandins","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4170050). assertion_content_comment('oboGo_SodiumIndependentthromboxanetransport',s("The","directed",",","sodium-independent",",","movement","of","thromboxanes","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","A","thromboxane","is","any","of","a","class","of","oxygenated","oxane","derivatives",",","originally","derived","from","prostaglandin","precursors","in","platelets",",","that","stimulate","aggregation","of","platelets","and","constriction","of","blood","vessels","."),4170040). assertion_content_comment('oboGo_SodiumIonTransportingfTypeatpasecomplex',s("A","sodium","ion-transporting","two-sector","ATPase","complex","that","catalyzes","the","phosphorylation","of","ADP","to","ATP",".","The","complex","comprises","a","membrane","sector","(","F0",")","that","carries","out","proton","transport","and","a","cytoplasmic","compartment","sector","(","F1",")","that","catalyzes","ATP","synthesis","by","a","rotational","mechanism","."),4304847). assertion_content_comment('oboGo_SodiumIonTransportingtwoSectoratpasecomplex',s("A","large","protein","complex","that","catalyzes","the","synthesis","or","hydrolysis","of","ATP","by","a","rotational","mechanism",",","coupled","to","the","transport","of","sodium","ions","across","a","membrane",".","The","complex","comprises","a","membrane","sector","(","F0","or","V0",")","that","carries","out","ion","transport","and","a","cytoplasmic","compartment","sector","(","F1","or","V1",")","that","catalyzes","ATP","synthesis","or","hydrolysis","."),4034338). assertion_content_comment('oboGo_SodiumIonTransportingvTypeatpasecomplex',s("A","sodium","ion-transporting","two-sector","ATPase","complex","that","couples","ATP","hydrolysis","to","the","transport","of","sodium","ions","across","a","concentration","gradient",".","The","complex","comprises","a","membrane","sector","(","V0",")","that","carries","out","proton","transport","and","a","cytoplasmic","compartment","sector","(","V1",")","that","catalyzes","ATP","hydrolysis","."),4304837). assertion_content_comment('oboGo_Sodium_PotassiumExchangingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","Na","+","(","in",")","+","K","+","(","out",")","=","ADP","+","phosphate","+","Na","+","(","out",")","+","K","+","(","in",")"),4219125). assertion_content_comment('oboGo_Sodium_PotassiumExchangingatpasecomplex',s("Sodium",":","potassium-exchanging","ATPases","are","tetrameric","proteins",",","consisting","of","two","large","alpha","subunits","and","two","smaller","beta","subunits",".","The","alpha","subunits","bear","the","active","site","and","penetrate","the","membrane",",","while","the","beta","subunits","carry","oligosaccharide","groups","and","face","the","cell","exterior","."),4008278). assertion_content_comment('oboGo_SodiumTranslocatingfTypeatpaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","+","Na","+","(","in",")","=","ADP","+","phosphate","+","Na","+","(","out",")","Found","in","eukaryotic","mitochondria","and","chloroplasts","and","in","bacteria","."),4304887). assertion_content_comment('oboGo_SodiumTranslocatingvTypeatpaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","+","Na","+","(","in",")","=","ADP","+","phosphate","+","Na","+","(","out",")","Found","in","vacuoles","of","eukaryotes","and","in","bacteria","."),4346635). assertion_content_comment('oboGo_SodiumTransportingatpaseactivityrotationalmechanism',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","Na","+","(","in",")","=","ADP","+","phosphate","+","Na","+","(","out",")",",","by","a","rotational","mechanism","."),4292141). assertion_content_comment('oboGo_SodiumTransportingatpsynthaseactivityrotationalmechanism',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ADP","+","phosphate","+","Na","+","(","out",")","=","ATP","+","H2O","+","Na","+","(","in",")",",","by","a","rotational","mechanism","."),4292128). assertion_content_comment('oboGo_SodiumTransportingtwoSectoratpaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","+","Na","+","(","in",")","=","ADP","+","phosphate","+","Na","+","(","out",")"),4292157). assertion_content_comment('oboGo_SomaticDiversificationOfDSCAMBasedimmunereceptors',s("The","somatic","process","that","results","in","the","generation","of","sequence","diversity","of","the","DSCAM-based","immune","receptors","of","insects","."),4377256). assertion_content_comment('oboGo_SomaticDiversificationOfFREPBasedimmunereceptors',s("The","process","that","results","in","the","generation","of","sequence","diversity","of","the","FREP-based","immune","receptors","of","snails","."),4381525). assertion_content_comment('oboGo_Sorbitol_6_PhosphataseActivity',s("Catalysis","of","the","reaction",":","D-glucitol","6-phosphate","+","H","(","2",")","O","=","D-glucitol","+","phosphate","."),4264210). assertion_content_comment('oboGo_Sorbitol_6_Phosphate2_DehydrogenaseActivity',s("Catalysis","of","the","reaction",":","D-sorbitol","6-phosphate","+","NAD","+","=","D-fructose","6-phosphate","+","NADH","+","H","+"),4256669). assertion_content_comment('oboGo_Sorbose5Dehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","L-sorbose","+","NADP","(","+",")","=","5-dehydro-D-fructose","+","H","(","+",")","+","NADPH","."),4264196). assertion_content_comment('oboGo_SpectrinAssociatedcytoskeleton',s("The","part","of","the","cytoskeleton","composed","of","spectrin",",","protein","4.1","and","ankyrin",".","Spectrin-associated","cytoskeleton","is","associated","with","the","plasma","membrane","."),4320686). assertion_content_comment('oboGo_SpermEggrecognition',s("The","initial","contact","step","made","between","the","sperm","plasma","membrane","and","outer","layer","of","the","egg","during","fertilization","."),4072615). assertion_content_comment('oboGo_Spermidine_CaffeoylCoANAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","caffeoyl","group","to","a","nitrogen","atom","on","the","spermidine","molecule","."),4182770). assertion_content_comment('oboGo_Spermidine_CoumaroylCoANAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","coumaroyl","group","to","a","nitrogen","atom","on","the","spermidine","molecule","."),4182761). assertion_content_comment('oboGo_Spermidine_FeruloylCoANAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","feruloyl","group","to","a","nitrogen","atom","on","the","spermidine","molecule","."),4182779). assertion_content_comment('oboGo_SpermidineImportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","spermidine","(","out",")","=","ADP","+","phosphate","+","spermidine","(","in",")"),4293597). assertion_content_comment('oboGo_Spermidine_SinapoylCoANAcyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","sinapoyl","group","to","a","nitrogen","atom","on","the","spermidine","molecule","."),4182752). assertion_content_comment('oboGo_SPhaseSpecifichistonemodification',s("The","covalent","alteration","of","one","or","more","amino","acid","residues","within","a","histone","protein","that","takes","place","during",",","and","results","in","a","modification","pattern","characteristic","of",",","S","phase","of","the","cell","cycle","."),4011081). assertion_content_comment('oboGo_SphericalHighDensitylipoproteinparticle',s("A","mature","high-density","lipoprotein","(","HDL",")","particle",",","converted","from","discoidal","HDL","particles","following","the","esterification","of","cholesterol","in","the","particle","by","phosphatidylcholine-sterol","O-acyltransferase","(","lecithin","cholesterol","acyltransferase",";","LCAT",")"),4355761). assertion_content_comment('oboGo_Sphinganine_1_PhosphateAldolaseActivity',s("Catalysis","of","the","reaction",":","sphinganine","1-phosphate","=","phosphoethanolamine","+","palmitaldehyde","."),4246332). assertion_content_comment('oboGo_Sphinganine_1_PhosphateBiosyntheticProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","sphinganine-1-phosphate",",","the","phosphorylated","derivative","of","D-erythro-2-amino-1",",","3-octadecanediol","."),4230635). assertion_content_comment('oboGo_Sphinganine_1_PhosphateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","sphinganine-1-phosphate",",","the","phosphorylated","derivative","of","D-erythro-2-amino-1",",","3-octadecanediol","."),4282283). assertion_content_comment('oboGo_Sphinganine_1_PhosphateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","sphinganine-1-phosphate",",","the","phosphorylated","derivative","of","D-erythro-2-amino-1",",","3-octadecanediol","."),4230628). assertion_content_comment('oboGo_SphingolipidDelta_4DesaturaseActivity',s("Catalysis","of","the","introduction","of","a","trans","double","bond","between","C4","and","C5","of","the","long","chain","base","region","of","a","sphingolipid",".","Sphingolipids","are","composed","of","a","long","chain","base","(","LCB",")","amide-linked","to","a","very","long","chain","fatty","acid","."),4314156). assertion_content_comment('oboGo_SphingolipidDelta_8DesaturaseActivity',s("Catalysis","of","the","formation","of","a","double","bond","between","C8","and","C9","of","the","long","chain","base","of","a","sphingolipid",".","For","example",",","sphinganine","(","d18",":","0",")","=","8-sphingenine","(","d18",":","1delta8",")",";","phytosphinganine","(","t18",":","0",")","=","8-phytosphingenine","(","t18",":","1delta8",")",";","and","4-sphingenine","(","18",":","1delta4",")","=","4",",","8-sphingadienine","(","d18",":","2delta4",",","8",")"),4191631). assertion_content_comment('oboGo_SphingolipidTranslocatingatpaseactivity',s("Catalysis","of","the","movement","of","sphingolipids","from","one","membrane","face","to","the","other","(","'","flippase","'","activity",")",",","driven","by","the","hydrolysis","of","ATP","."),4359977). assertion_content_comment('oboGo_Sphingosine_1_PhosphatePhosphataseActivity',s("Catalysis","of","the","reaction",":","sphingosine","1-phosphate","+","H2O","=","sphingosine","+","phosphate","."),4312786). assertion_content_comment('oboGo_SphingosineBetaGalactosyltransferaseactivity',s("Catalysis","of","the","reaction",":","sphingosine","+","UDP-D-galactose","=","H","(","+",")","+","psychosine","+","UDP","."),4367242). assertion_content_comment('oboGo_SphingosineNAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","sphingosine","=","CoA","+","N-acylsphingosine","."),4264280). assertion_content_comment('oboGo_SporeBearingorgandevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","spore-bearing","organ","over","time",",","from","its","formation","to","the","mature","structure",".","A","spore-bearing","organ","is","an","anatomical","structure","that","produces","new","spores","."),3978776). assertion_content_comment('oboGo_SporophyticSelfIncompatibility',s("OBSOLETE",".","A","mechanism","that","functions","to","prevent","self-fertilization","in","flowering","plants","that","is","determined","by","the","diploid","genotype","of","the","parent","plant",".","In","sporophytic","incompatibility","the","pollen","does","not","germinate",",","consequently","fertilization","does","not","take","place","."),4262228). assertion_content_comment('oboGo_SqualeneHopenecyclaseactivity',s("Catalysis","of","the","reaction",":","squalene","=","hop-22","(","29",")","-ene","."),4279209). assertion_content_comment('oboGo_SREBPMediatedsignalingpathway',s("A","series","of","molecular","signals","from","the","endoplasmic","reticulum","to","the","nucleus","generated","as","a","consequence","of","altered","levels","of","one","or","more","lipids",",","and","resulting","in","the","activation","of","transcription","by","SREBP","."),4013638). assertion_content_comment('oboGo_SREBPScapcomplex',s("A","protein","complex","formed","by","the","association","of","sterol","regulatory","element","binding","protein","(","SREBP",")","and","SREBP-cleavage-activating","protein","(","SCAP",")","in","the","ER","membrane",";","in","the","absence","of","sterols",",","the","SREBP-SCAP","complex","is","packaged","into","COPII","vesicles","and","travels","to","the","Golgi","apparatus","to","be","processed","."),4336983). assertion_content_comment('oboGo_SREBPScapInsigcomplex',s("A","protein","complex","formed","by","the","association","of","sterol","regulatory","element","binding","protein","(","SREBP",")",",","SREBP-cleavage-activating","protein","(","SCAP",")",",","and","an","Insig","protein","(","Insig-1","or","Insig-2",")","the","ER","membrane","."),4064022). assertion_content_comment('oboGo_SRFMyogeninE12complex',s("A","transcription","factor","complex","that","contains","the","serum","response","factor","(","SRF",")","and","the","basic","helix-loop-helix","proteins","myogenin","and","E12",",","and","is","involved","in","activating","transcription","of","muscle-specific","genes","."),4174954). assertion_content_comment('oboGo_SRibosylhomocysteinelyaseactivity',s("Catalysis","of","the","reaction",":","S-","(","5-deoxy-D-ribos-5-yl",")","-L-homocysteine","=","(","S",")","-4",",","5-dihydroxypentane-2",",","3-dione","+","L-homocysteine","."),4327918). assertion_content_comment('oboGo_SRPDependentcotranslationalproteintargetingtomembranedocking',s("The","process","in","which","an","SRP-bound","ribosome","forms","a","complex","with","the","SRP","receptor","in","the","ER","membrane",",","allowing","the","ribosome","to","bind","to","the","membrane",",","during","cotranslational","membrane","targeting","."),4013918). assertion_content_comment('oboGo_SRPDependentcotranslationalproteintargetingtomembranesignalsequenceprocessing',s("The","removal","of","the","signal","peptide","from","a","nascent","protein","during","cotranslational","membrane","targeting","."),4013950). assertion_content_comment('oboGo_SRPDependentcotranslationalproteintargetingtomembranesignalsequencerecognition',s("The","process","in","which","SRP","binds","to","the","signal","peptide","in","a","nascent","protein",",","causing","protein","elongation","to","pause",",","during","cotranslational","membrane","targeting","."),4013963). assertion_content_comment('oboGo_SRPDependentcotranslationalproteintargetingtomembrane',s("The","targeting","of","proteins","to","a","membrane","that","occurs","during","translation","and","is","dependent","upon","two","key","components",",","the","signal-recognition","particle","(","SRP",")","and","the","SRP","receptor",".","SRP","is","a","cytosolic","particle","that","transiently","binds","to","the","endoplasmic","reticulum","(","ER",")","signal","sequence","in","a","nascent","protein",",","to","the","large","ribosomal","unit",",","and","to","the","SRP","receptor","in","the","ER","membrane","."),4013895). assertion_content_comment('oboGo_SRPDependentcotranslationalproteintargetingtomembranetranslocation',s("The","process","during","cotranslational","membrane","targeting","wherein","proteins","move","across","a","membrane",".","SRP","and","its","receptor","initiate","the","transfer","of","the","nascent","chain","across","the","endoplasmic","reticulum","(","ER",")","membrane",";","they","then","dissociate","from","the","chain",",","which","is","transferred","to","a","set","of","transmembrane","proteins",",","collectively","called","the","translocon",".","Once","the","nascent","chain","translocon","complex","is","assembled",",","the","elongating","chain","passes","directly","from","the","large","ribosomal","subunit","into","the","centers","of","the","translocon",",","a","protein-lined","channel","within","the","membrane",".","The","growing","chain","is","never","exposed","to","the","cytosol","and","does","not","fold","until","it","reaches","the","ER","lumen","."),4014009). assertion_content_comment('oboGo_SRPIndependentcotranslationalproteinMembranetargeting',s("OBSOLETE",".","The","targeting","of","proteins","to","a","membrane","that","occurs","during","translation","and","is","independent","of","SRP","and","signal","recognition","."),4230312). assertion_content_comment('oboGo_SRPIndependentcotranslationalproteinMembranetargetingtranslocation',s("OBSOLETE",".","The","process","during","cotranslational","membrane","targeting","wherein","proteins","move","across","a","membrane",".","This","process","is","independent","of","SRP","and","signal","recognition","."),4298492). assertion_content_comment('oboGo_SSButanedioldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","S",",","S",")","-butane-2",",","3-diol","+","NAD","(","+",")","=","acetoin","+","H","(","+",")","+","NADH","."),4371656). assertion_content_comment('oboGo_SScoulerine9OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-scoulerine","+","S-adenosyl-L-methionine","(","1","+",")","=","(","S",")","-tetrahydrocolumbamine","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4309189). assertion_content_comment('oboGo_SShapedbodymorphogenesis',s("The","process","in","which","the","S-shaped","body","is","generated","and","organized",".","The","S-shaped","body","is","the","successor","of","the","comma-shaped","body","that","contributes","to","the","morphogenesis","of","the","nephron","."),4123647). assertion_content_comment('oboGo_SSL2Coretfiihcomplexportionofholotfiihcomplex',s("The","SSL2-core","TFIIH","complex","when","it","is","part","of","the","general","transcription","factor","TFIIH",".","It","is","composed","of","the","tightly","associated","five","subunit","core","TFIIH","subcomplex","plus","one","additional",",","less","tighly","associated","subunit",".","The","subunits","are","well","conserved","from","yeast","to","humans",".","In","S",".","cerevisiae",",","the","5-subunit","core","is","composed","of","Rad3",",","Tfb1",",","Tfb2",",","Ssl1",",","Tfb4","and","the","loosely","associated","subunit","is","Ssl2p","(","also","called","Rad25",")","In","humans",",","the","5","subunit","core","is","composed","of","ERCC2",",","p62",",","p55",",","p44",",","p34","and","the","loosely","associated","subunit","is","XPB","."),3976546). assertion_content_comment('oboGo_SSL2Coretfiihcomplexportionofnef3complex',s("The","SSL2-core","TFIIH","complex","when","it","is","part","of","the","nucleotide-excision","repair","factor","3","(","NEF3",")","It","is","composed","of","the","tightly","associated","5","subunit","core","TFIIH","subcomplex","plus","one","additional",",","less","tighly","associated","subunit",".","The","subunits","are","well","conserved","from","yeast","to","humans",".","In","S",".","cerevisiae",",","the","5-subunit","core","is","composed","of","Rad3",",","Tfb1",",","Tfb2",",","Ssl1",",","Tfb4","and","the","loosely","associated","subunit","is","Ssl2p","(","also","called","Rad25",")","In","humans",",","the","5","subunit","core","is","composed","of","ERCC2",",","p62",",","p55",",","p44",",","p34","and","the","loosely","associated","subunit","is","XPB","."),3976612). assertion_content_comment('oboGo_SSL2Coretfiihcomplex',s("A","complex","which","is","part","of","both","the","general","transcription","factor","TFIIH","and","the","nucleotide-excision","repair","factor","3","complex",".","It","is","composed","of","the","tightly","associated","5","subunit","core","TFIIH","subcomplex","plus","one","additional",",","more","loosely","associated","subunit",".","The","subunits","are","well","conserved","from","yeast","to","humans",".","In","S",".","cerevisiae",",","the","5-subunit","core","is","composed","of","Rad3",",","Tfb1",",","Tfb2",",","Ssl1",",","Tfb4","and","the","loosely","associated","subunit","is","Ssl2p","(","also","called","Rad25",")","In","humans",",","the","5","subunit","core","is","composed","of","ERCC2",",","p62",",","p55",",","p44",",","p34","and","the","loosely","associated","subunit","is","XPB","."),3976488). assertion_content_comment('oboGo_SStylopinesynthaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-cheilanthifoline","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","(","S",")","-stylopine","+","2","H","(","2",")","O","+","NADP","(","+",")"),4364861). assertion_content_comment('oboGo_SSuccinylglutathionehydrolaseactivity',s("Catalysis","of","the","reaction",":","S-succinylglutathione","+","H","(","2",")","O","=","glutathione","+","H","(","+",")","+","succinate","."),4264032). assertion_content_comment('oboGo_SSuccinyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","succinyl","group","to","a","sulfur","atom","on","the","acceptor","molecule","."),4211070). assertion_content_comment('oboGo_StearoylCoa9Desaturaseactivity',s("Catalysis","of","the","reaction",":","stearoyl-CoA","+","2","ferrocytochrome","b5","+","O2","+","2","H","+","=","oleoyl-CoA","+","2","ferricytochrome","b5","+","H2O","."),4201585). assertion_content_comment('oboGo_Stemar_13_EneSynthaseActivity',s("Catalysis","of","the","reaction",":","9-alpha-copalyl","diphosphate","=","stemar-13-ene","+","diphosphate","."),4360258). assertion_content_comment('oboGo_Sterigmatocystin7OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","sterigmatocystin","+","S-adenosyl-L-methionine","=","7-O-methylsterigmatocystin","+","S-adenosyl-homocysteine","."),4365446). assertion_content_comment('oboGo_Steroid11BetaMonooxygenaseactivity',s("Catalysis","of","the","reaction",":","a","steroid","+","reduced","adrenal","ferredoxin","+","O2","=","an","11-beta-hydroxysteroid","+","oxidized","adrenal","ferredoxin","+","H2O","."),4205290). assertion_content_comment('oboGo_Steroid17AlphaMonooxygenaseactivity',s("Catalysis","of","the","reaction",":","a","steroid","+","AH2","+","O2","=","a","17a-hydroxysteroid","+","A","+","H2O","."),4205236). assertion_content_comment('oboGo_Steroid21Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","a","steroid","+","donor-H2","+","O2","=","a","21-hydroxysteroid","+","acceptor","+","H2O","."),4205258). assertion_content_comment('oboGo_Steroid22Alphahydroxylaseactivity',s("Catalysis","of","the","reaction",":","5-alpha-campestanaol","+","O2","=","6-deoxocathasterone","+","H2O","."),4329971). assertion_content_comment('oboGo_Steroid7AlphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","a","steroid","+","donor-H2","+","O2","=","7-alpha-hydroxysteroid","+","H2O","."),4255509). assertion_content_comment('oboGo_Steroid9AlphaMonooxygenaseactivity',s("Catalysis","of","the","reaction",":","AH","(","2",")","+","O","(","2",")","+","pregna-4",",","9","(","11",")","-diene-3",",","20-dione","=","9",",","11alpha-epoxypregn-4-ene-3",",","20-dione","+","A","+","H","(","2",")","O","."),4264266). assertion_content_comment('oboGo_SteroidDehydrogenaseActivityActingOnTheCHChgroupofdonors',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-CH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","a","hydrogen","or","electron","acceptor",",","and","in","which","one","substrate","is","a","sterol","derivative","."),4189255). assertion_content_comment('oboGo_SteroidDehydrogenaseActivityActingOnTheCHOhgroupofdonorsnadornadpasacceptor',s("Catalysis","of","an","oxidation-reduction","(","redox",")","reaction","in","which","a","CH-OH","group","acts","as","a","hydrogen","or","electron","donor","and","reduces","NAD","+","or","NADP",",","and","in","which","one","substrate","is","a","sterol","derivative","."),4157660). assertion_content_comment('oboGo_SteroidDeltaIsomeraseactivity',s("Catalysis","of","the","reaction",":","a","3-oxo-delta","(","5",")","-steroid","=","a","3-oxo-delta","(","4",")","-steroid","."),4201614). assertion_content_comment('oboGo_SteroidLactonaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","testololactone","=","H","(","+",")","+","testolate","."),4264255). assertion_content_comment('oboGo_SteroidNAcetylglucosaminyltransferaseactivity',s("Catalysis","of","the","reaction",":","estradiol-17alpha","3-D-glucuronoside","+","UDP-N-acetyl-alpha-D-glucosamine","=","17alpha-","(","N-acetyl-D-glucosaminyl",")","-estradiol","3-D-glucuronoside","+","H","(","+",")","+","UDP","."),4367036). assertion_content_comment('oboGo_Sterol12AlphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","a","steroid","+","donor-H2","+","O2","=","12-alpha-hydroxysteroid","+","H2O","."),4255606). assertion_content_comment('oboGo_Sterol14Demethylaseactivity',s("Catalysis","of","the","reaction",":","obtusifoliol","+","3","O2","+","3","NADPH","+","3","H","+","=","4-alpha-methyl-5-alpha-ergosta-8",",","14",",","24","(","28",")","-trien-3-beta-ol","+","formate","+","3","NADP","+","+","3","H2O","."),4255618). assertion_content_comment('oboGo_Sterol24CMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","5-alpha-cholest-8",",","24-dien-3-beta-ol","=","S-adenosyl-L-homocysteine","+","24-methylene-5-alpha-cholest-8-en-3-beta-ol","."),4188722). assertion_content_comment('oboGo_Sterol3BetaGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","a","sterol","=","UDP","+","an","O-glucosylsterol","."),4283333). assertion_content_comment('oboGo_Sterol_4_Alpha_Carboxylate3_DehydrogenaseDecarboxylatingActivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","+","+","3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate","=","NAD","(","P",")","H","+","H","+","+","CO2","+","4-alpha-methyl-5-alpha-cholest-7-en-3-one","."),4364038). assertion_content_comment('oboGo_Sterol5Alphareductaseactivity',s("Catalysis","of","the","removal","of","a","C-5","double","bond","in","the","B","ring","of","a","sterol","."),4261881). assertion_content_comment('oboGo_SterolDependentproteinbinding',s("Interacting","selectively","and","non-covalently","with","any","protein","or","protein","complex","(","a","complex","of","two","or","more","proteins","that","may","include","other","nonprotein","molecules",")","in","the","presence","of","sterols","."),4178610). assertion_content_comment('oboGo_SterolOAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","a","sterol","=","CoA","+","a","sterol","ester","."),4201724). assertion_content_comment('oboGo_SterolRegulatoryElementBindingProteinCleavageInvolvedInERNuclearsterolresponsepathway',s("The","proteolytic","release","of","a","transcriptionally","active","sterol","regulatory","element","binding","protein","(","SREBP",")","from","intracellular","membranes",",","freeing","it","to","move","to","the","nucleus","and","upregulate","transcription","of","target","genes",",","in","response","to","depleted","sterol","levels","."),4013688). assertion_content_comment('oboGo_SterolRegulatoryElementBindingproteinproteaseactivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","peptide","bonds","within","a","sterol","regulatory","element","binding","protein","(","SREBP",")","SREBPs","are","transcription","factors","that","bind","sterol","regulatory","elements","(","SREs",")",",","DNA","motifs","found","in","the","promoters","of","target","genes","."),4267718). assertion_content_comment('oboGo_SterolRegulatoryElementBindingproteinsite1proteaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","a","Leu-Ser","bond","within","the","luminal","loop","of","a","sterol","regulatory","element","binding","protein","(","SREBP",")","This","activity","is","the","first","of","two","sequential","cleavage","reactions","and","cleaves","SREBP","into","two","membrane-bound","halves","."),4267753). assertion_content_comment('oboGo_SterolRegulatoryElementBindingproteinsite2proteaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage",",","within","the","membrane-spanning","helix",",","of","the","amino-terminal","half","(","the","intermediate","form",")","of","sterol","regulatory","element","binding","protein","(","SREBP",")","This","activity","releases","the","transcription","factor","domain","of","SREBP","from","the","membrane",",","freeing","it","to","enter","the","nucleus","."),4267730). assertion_content_comment('oboGo_SterolTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","sterol","(","in",")","=","ADP","+","phosphate","+","sterol","(","out",")"),4360922). assertion_content_comment('oboGo_SterylBetaGlucosidaseactivity',s("Catalysis","of","the","reaction",":","cholesteryl-beta-D-glucoside","+","H","(","2",")","O","=","D-glucose","+","cholesterol","."),4264325). assertion_content_comment('oboGo_SterylSulfataseactivity',s("Catalysis","of","the","reaction",":","3-beta-hydroxyandrost-5-en-17-one","3-sulfate","+","H2O","=","3-beta-hydroxyandrost-5-en-17-one","+","sulfate","."),4201774). assertion_content_comment('oboGo_STetrahydroprotoberberinenMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","(","S",")","-7",",","8",",","13",",","14-tetrahydroprotoberberine","=","S-adenosyl-L-homocysteine","+","cis-N-methyl-","(","S",")","-7",",","8",",","13",",","14-tetrahydroprotoberberine","."),4309200). assertion_content_comment('oboGo_StigmasterolUDPGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","a","sterol","=","UDP","+","O-glucosyl-stigmasterol","."),4283375). assertion_content_comment('oboGo_StimulatoryCTypelectinreceptorsignalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","C-type","lectin","receptor","capable","of","cellular","activation","."),4377630). assertion_content_comment('oboGo_StimulatoryKillerCellImmunoglobulinLikereceptorsignalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","killer","cell","immunoglobulin-like","receptor","capable","of","cellular","activation","."),4377594). assertion_content_comment('oboGo_Stn1Ten1complex',s("A","nuclear","telomere","cap","complex","that","is","formed","by","the","association","of","the","Stn1","and","Ten1","proteins","with","telomeric","DNA",";","in","some","species","a","third","protein","is","present","."),4179328). assertion_content_comment('oboGo_StoreOperatedcalciumchannelactivity',s("A","ligand-gated","ion","channel","activity","which","transports","calcium","in","response","to","emptying","of","intracellular","calcium","stores","."),4295230). assertion_content_comment('oboGo_StoreOperatedcalciumentry',s("A","calcium","ion","entry","mechanism","in","the","plasma","membrane","activated","by","the","depletion","of","calcium","ion","from","the","internal","calcium","ion","store","in","the","endoplasmic","reticulum","."),4374691). assertion_content_comment('oboGo_StrandInvasionInvolvedInGeneConversionAtMatingTypelocus',s("The","process","in","which","the","nucleoprotein","complex","(","composed","of","the","broken","single-strand","DNA","and","the","recombinase",")","searches","and","identifies","a","region","of","homology","in","intact","duplex","DNA","at","the","mating-type","locus",".","The","broken","single-strand","DNA","displaces","the","like","strand","and","forms","Watson-Crick","base","pairs","with","its","complement",",","forming","a","duplex","in","which","each","strand","is","from","one","of","the","two","recombining","DNA","molecules",".","This","process","occurs","as","part","of","gene","conversion","at","the","mating-type","locus","."),4073499). assertion_content_comment('oboGo_Streptomycin3Kinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","streptomycin","=","ADP","+","2","H","(","+",")","+","streptomycin","3","'","'","-phosphate","."),4264502). assertion_content_comment('oboGo_Streptomycin_6_PhosphataseActivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","streptomycin","6-phosphate","=","phosphate","+","streptomycin","."),4265779). assertion_content_comment('oboGo_StressActivatedmapkcascade',s("A","series","of","molecular","signals","in","which","a","stress-activated","MAP","kinase","cascade","relays","one","or","more","of","the","signals",";","MAP","kinase","cascades","involve","at","least","three","protein","kinase","activities","and","culminate","in","the","phosphorylation","and","activation","of","a","MAP","kinase","."),4070132). assertion_content_comment('oboGo_StressActivatedproteinkinasesignalingcascade',s("A","series","of","molecular","signals","in","which","a","stress-activated","protein","kinase","(","SAPK",")","cascade","relays","one","or","more","of","the","signals","."),4016516). assertion_content_comment('oboGo_StressInducedprematuresenescence',s("A","cellular","senescence","process","associated","with","the","dismantling","of","a","cell","as","a","response","to","environmental","factors","such","as","hydrogen","peroxide","or","X-rays","."),4155128). assertion_content_comment('oboGo_StretchActivatedcationSelectivecalciumchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","calcium","ion","by","a","channel","that","opens","in","response","to","a","mechanical","stress","in","the","form","of","stretching","."),4295210). assertion_content_comment('oboGo_STriazinecompoundcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","s-triazine","compound",".","These","compounds","include","many","pesticides","of","widespread","use","in","agriculture",",","and","are","characterized","by","a","symmetrical","hexameric","ring","consisting","of","alternating","carbon","and","nitrogen","atoms","."),4239690). assertion_content_comment('oboGo_STriazinecompoundmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","any","s-triazine","compound",".","These","compounds","include","many","pesticides","of","widespread","use","in","agriculture",",","and","are","characterized","by","a","symmetrical","hexameric","ring","consisting","of","alternating","carbon","and","nitrogen","atoms","."),4239671). assertion_content_comment('oboGo_STriazinehydrolaseactivity',s("Catalysis","of","the","reaction",":","1-halo","or","1-pseudohalo-S-triazine","=","1-hydroxy-S-triazine","."),4274315). assertion_content_comment('oboGo_StrictosidineBetaGlucosidaseactivity',s("Catalysis","of","the","reaction",":","3alpha","(","S",")","-strictosidine","+","H","(","2",")","O","=","D-glucose","+","strictosidine","aglycone","."),4266914). assertion_content_comment('oboGo_StromalEpithelialcellsignalinginvolvedinprostateglanddevelopment',s("The","process","of","transferring","information","from","a","stromal","cell","to","an","epithelial","cell","where","it","is","received","and","interpreted",",","as","part","of","prostate","gland","development","."),4096779). assertion_content_comment('oboGo_StructuralConstituentOfAdultChitinBasedcuticle',s("The","action","of","a","molecule","that","contributes","to","the","structural","integrity","of","the","chitin-based","cuticle","of","an","adult","organism",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4247398). assertion_content_comment('oboGo_StructuralConstituentOfChitinBasedcuticle',s("The","action","of","a","molecule","that","contributes","to","the","structural","integrity","of","a","chitin-based","cuticle",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4217594). assertion_content_comment('oboGo_StructuralConstituentOfChitinBasedlarvalcuticle',s("The","action","of","a","molecule","that","contributes","to","the","structural","integrity","of","the","chitin-based","cuticle","of","a","larva",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4247378). assertion_content_comment('oboGo_StructuralConstituentOfCollagenAndCuticulinBasedcuticle',s("The","action","of","a","molecule","that","contributes","to","the","structural","integrity","of","a","collagen","and","cuticulin-based","cuticle",".","An","example","of","this","process","is","found","in","Caenorhabditis","elegans","."),4312871). assertion_content_comment('oboGo_StructuralConstituentOfPupalChitinBasedcuticle',s("The","action","of","a","molecule","that","contributes","to","the","structural","integrity","of","the","chitin-based","cuticle","of","a","pupa",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4247388). assertion_content_comment('oboGo_StructureSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","DNA","of","a","specific","structure","or","configuration","e.g",".","triplex","DNA","binding","or","bent","DNA","binding","."),4173165). assertion_content_comment('oboGo_StyreneOxideisomeraseactivity',s("Catalysis","of","the","reaction",":","styrene","oxide","=","phenylacetaldehyde","."),4273848). assertion_content_comment('oboGo_SubstrateAdhesionDependentcellspreading',s("The","morphogenetic","process","that","results","in","flattening","of","a","cell","as","a","consequence","of","its","adhesion","to","a","substrate","."),4357227). assertion_content_comment('oboGo_SubstrateBoundcellmigrationadhesionreceptorrecycling',s("The","directed","movement","of","accumulated","adhesion","components","such","as","integrins","from","the","rear","of","a","migrating","cell","toward","the","cell","front",",","where","they","are","available","to","form","new","protrusions","and","adhesions","."),4011414). assertion_content_comment('oboGo_SubstrateDependentcellmigrationcellattachmenttosubstrate',s("The","formation","of","adhesions","that","stabilize","protrusions","at","the","leading","edge","of","a","migrating","cell",";","involves","integrin","activation",",","clustering",",","and","the","recruitment","of","structural","and","signaling","components","to","nascent","adhesions","."),4011435). assertion_content_comment('oboGo_SubstrateDependentcellmigrationcellcontraction',s("The","translocation","of","the","cell","body","forward","during","cell","migration",",","mediated","by","tractional","force","on","its","substrate","and","tension","in","the","cortical","cytoskeleton",".","Adhesions","transmit","propulsive","forces","and","serve","as","traction","points","over","which","the","cell","moves","."),4011392). assertion_content_comment('oboGo_SubstrateDependentcellmigrationcellextension',s("The","formation","of","a","cell","surface","protrusion",",","such","as","a","lamellipodium","or","filopodium",",","at","the","leading","edge","of","a","migrating","cell","."),4011424). assertion_content_comment('oboGo_SubstrateDependentcellmigration',s("The","orderly","movement","of","a","cell","from","one","site","to","another","along","a","substrate","such","as","the","extracellular","matrix",";","the","migrating","cell","forms","a","protrusion","that","attaches","to","the","substrate","."),4011389). assertion_content_comment('oboGo_SubstrateDependentcerebralcortextangentialmigration',s("The","process","where","neuronal","precursors","migrate","tangentially","in","the","cerebral","cortex",",","primarily","guided","through","physical","cell-cell","interactions","."),4051126). assertion_content_comment('oboGo_SubstrateIndependenttelencephalictangentialinterneuronmigration',s("The","directional","movement","of","tangentially","migrating","interneurons","that","are","not","guided","by","attaching","to","extracellular","substrates","."),4050731). assertion_content_comment('oboGo_SubstrateIndependenttelencephalictangentialmigration',s("The","process","where","neuronal","precursors","migrate","tangentially","in","the","telencephalon",",","primarily","guided","by","interactions","that","do","not","require","cell-cell","contact","."),4050729). assertion_content_comment('oboGo_SubstrateSpecificchannelactivity',s("Catalysis","of","energy-independent","facilitated","diffusion",",","mediated","by","passage","of","a","specific","solute","through","a","transmembrane","aqueous","pore","or","channel",".","Stereospecificity","is","not","exhibited","but","this","transport","may","be","specific","for","a","particular","molecular","species","or","class","of","molecules","."),4158371). assertion_content_comment('oboGo_SubstrateSpecifictransmembranetransporteractivity',s("Enables","the","transfer","of","a","specific","substance","or","group","of","related","substances","from","one","side","of","a","membrane","to","the","other","."),4020385). assertion_content_comment('oboGo_SubstrateSpecifictransporteractivity',s("Enables","the","directed","movement","of","a","specific","substance","or","group","of","related","substances","(","such","as","macromolecules",",","small","molecules",",","ions",")","into",",","out","of","or","within","a","cell",",","or","between","cells","."),4020383). assertion_content_comment('oboGo_SuccinateCitramalatecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","S-citramalate","+","succinyl-CoA","=","citramalyl-CoA","+","succinate","."),4368735). assertion_content_comment('oboGo_SuccinateCoaligaseactivity',s("Catalysis","of","the","reaction",":","succinate","+","CoA","+","nucleotide","triphosphate","=","nucleotide","diphosphate","+","phosphate","+","succinyl-CoA","."),4201797). assertion_content_comment('oboGo_SuccinateCoaligaseadpFormingactivity',s("Catalysis","of","the","reaction",":","ATP","+","succinate","+","CoA","=","ADP","+","succinyl-CoA","+","phosphate","."),4201807). assertion_content_comment('oboGo_SuccinateCoaligasecomplexadpForming',s("A","heterodimeric","enzyme","complex",",","composed","of","an","alpha","and","beta","chain",",","most","usually","found","in","(","but","not","limited","to",")","bacteria",".","Functions","in","the","TCA","cycle",",","hydrolyzing","succinyl-CoA","into","succinate","and","CoA",",","thereby","forming","ATP","."),4260145). assertion_content_comment('oboGo_SuccinateCoaligasecomplexgdpForming',s("A","heterodimeric","enzyme","complex",",","usually","composed","of","an","alpha","and","beta","chain",".","Functions","in","the","TCA","cycle",",","hydrolyzing","succinyl-CoA","into","succinate","and","CoA",",","thereby","forming","GTP","."),4298821). assertion_content_comment('oboGo_SuccinateCoaligasecomplex',s("A","heterodimeric","enzyme","complex",",","usually","composed","of","an","alpha","and","beta","chain",".","Functions","in","the","TCA","cycle",",","hydrolyzing","succinyl-CoA","into","succinate","and","CoA",",","thereby","forming","ATP","or","GTP","."),4260143). assertion_content_comment('oboGo_SuccinateCoaligasegdpFormingactivity',s("Catalysis","of","the","reaction",":","GTP","+","succinate","+","CoA","=","GDP","+","succinyl-CoA","+","phosphate","."),4201826). assertion_content_comment('oboGo_SuccinateHydroxymethylglutaratecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-hydroxy-3-methylglutarate","+","succinyl-CoA","=","3-hydroxy-3-methyl-glutaryl-CoA","+","succinate","."),4367884). assertion_content_comment('oboGo_SuccinateSemialdehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","succinate","semialdehyde","+","NAD","+","+","H2O","=","succinate","+","NADH","+","H","+"),4201737). assertion_content_comment('oboGo_SuccinateSemialdehydedehydrogenasebinding',s("Interacting","selectively","and","non-covalently","with","succinate-semialdehyde","dehydrogenase","."),4329127). assertion_content_comment('oboGo_SuccinateSemialdehydedehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","succinate","semialdehyde","+","NAD","(","P",")","+","+","H2O","=","succinate","+","NAD","(","P",")","H","+","H","+"),4256643). assertion_content_comment('oboGo_SuccinylCoahydrolaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","succinyl-CoA","=","CoA","+","H","(","+",")","+","succinate","."),4201751). assertion_content_comment('oboGo_SuccinylCoametabolicprocess',s("The","chemical","reactions","and","pathways","involving","succinyl-CoA",",","a","compound","composed","of","the","monovalent","acyl","group","3-carboxypropanoyl",",","derived","from","succinic","acid","by","loss","of","one","OH","group",",","linked","to","coenzyme","A","."),4014576). assertion_content_comment('oboGo_SuccinylCoapathway',s("The","chemical","reactions","that","utilize","succinyl-CoA","in","the","synthesis","of","protoporphyrin","IX","."),4014581). assertion_content_comment('oboGo_SuccinylCoa_RBenzylsuccinatecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-2-benzylsuccinate","+","succinyl-CoA","=","(","R",")","-2-benzylsuccinyl-CoA","+","succinate","."),4343507). assertion_content_comment('oboGo_SuccinylCoa_RCitramalatecoaTransferaseactivity',s("Catalysis","of","the","reaction",":","succinyl-CoA","+","(","R",")","-citramalate","=","succinate","+","(","R",")","-citramalyl-CoA","."),4328190). assertion_content_comment('oboGo_SuccinylDiaminopimelatedesuccinylaseactivity',s("Catalysis","of","the","reaction",":","N-succinyl-LL-2",",","6-diaminopimelate","+","H","(","2",")","O","=","LL-2",",","6-diaminopimelate","+","succinate","."),4256631). assertion_content_comment('oboGo_SuccinylglutamateSemialdehydedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","N-succinyl-L-glutamate","5-semialdehyde","+","H","(","2",")","O","+","NAD","(","+",")","=","N-succinyl-L-glutamate","+","2","H","(","+",")","+","NADH","."),4327180). assertion_content_comment('oboGo_SucraseIsomaltasecomplex',s("A","protein","complex","that","possesses","oligo-1",",","6-glucosidase","activity",";","the","complex","is","a","heterodimer","located","in","the","cell","membrane",",","and","is","formed","by","proteolytic","cleavage","of","a","single","precursor","polypeptide",".","The","two","subunits","have","different","substrate","specificities","."),4133801). assertion_content_comment('oboGo_Sucrose_16_Alpha_Glucan36_Alpha_GlucosyltransferaseActivity',s("Catalysis","of","the","reaction",":","sucrose","+","1",",","6-alpha-D-glucosyl","(","n",")","=","1",",","6-alpha-D-glucosyl","(","n","+","1",")","+","fructose","."),4366698). assertion_content_comment('oboGo_Sucrose1FFructosyltransferaseactivity',s("Catalysis","of","the","reaction",":","2","sucrose","=","D-glucose","+","1F-beta-D-fructosylsucrose","."),4265742). assertion_content_comment('oboGo_Sucrose6FAlphaGalactotransferaseactivity',s("Catalysis","of","the","reaction",":","sucrose","+","UDP-galactose","=","6F-alpha-D-galactosylsucrose","+","UDP","."),4366942). assertion_content_comment('oboGo_SucroseAlphaGlucosidaseactivity',s("Catalysis","of","the","reaction",":","sucrose","+","H2O","=","alpha-D-glucose","+","beta-D-fructose","."),4204385). assertion_content_comment('oboGo_SucroseCatabolicProcessUsingBetaFructofuranosidase',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","sucrose",",","catalyzed","by","the","enzyme","beta-fructofuranosidase","(","EC",":","3.2.1.26",")"),4243261). assertion_content_comment('oboGo_SucroseCatabolicProcessUsingGlucoside3Dehydrogenase',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","sucrose",",","catalyzed","by","the","enzyme","glucoside","3-dehydrogenase","(","EC",":","1.1.99.13",")"),4243197). assertion_content_comment('oboGo_SucrosePhosphataseactivity',s("Catalysis","of","the","reaction",":","sucrose","6F-phosphate","+","H2O","=","sucrose","+","phosphate","."),4265818). assertion_content_comment('oboGo_SucrosePhosphatesynthaseactivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","D-fructose","6-phosphate","=","UDP","+","sucrose","6-phosphate","."),4359161). assertion_content_comment('oboGo_SugarPhosphataseactivity',s("Catalysis","of","the","reaction",":","sugar","phosphate","+","H2O","=","sugar","+","phosphate","."),4265832). assertion_content_comment('oboGo_SugarTerminalPhosphataseactivity',s("Catalysis","of","the","reaction",":","H2O","+","a","sugar","phosphate","=","a","sugar","+","phosphate",";","for","example",":","D-glucose","6-phosphate","+","H2O","=","D-glucose","+","phosphate","."),4265842). assertion_content_comment('oboGo_SulfateAssimilationPhosphoadenylylSulfateReductionByPhosphoadenylylSulfatereductasethioredoxin',s("The","pathway","by","which","inorganic","sulfate","is","processed","and","incorporated","into","sulfated","compounds",",","where","the","phosphoadenylyl","sulfate","reduction","step","is","catalyzed","by","the","enzyme","phosphoadenylyl-sulfate","reductase","(","thioredoxin",")","(","EC",":","1.8.4.8",")"),4240029). assertion_content_comment('oboGo_SulfateTransmembraneTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","sulfate","(","out",")","=","ADP","+","phosphate","+","sulfate","(","in",")"),4291516). assertion_content_comment('oboGo_SulfolactateSulfoLyaseactivity',s("Catalysis","of","the","reaction",":","3-sulfolactate","=","pyruvate","+","sulfite","."),4360632). assertion_content_comment('oboGo_SulfurIncorporationIntoMetalloSulfurcluster',s("The","incorporation","of","exogenous","sulfur","into","a","metallo-sulfur","cluster","."),4062433). assertion_content_comment('oboGo_SulfurOxidationFerricIonDependent',s("A","sulfur","oxidation","process","that","proceeds","via","the","reaction","catalyzed","by","sulfur",":","ferric","ion","oxidoreductase",",","and","requires","the","presence","of","ferric","ion","(","Fe3","+",")"),4240735). assertion_content_comment('oboGo_SulfurOxygenaseReductaseActivity_4',s("Catalysis","of","the","reaction",":","4","sulfur","+","4","H2O","+","O2","=","2","hydrogen","sulfide","+","2","bisulfite","+","2","H","+"),4342627). assertion_content_comment('oboGo_SulochrinOxidaseBisdechlorogeodinFormingactivity',s("Catalysis","of","the","reaction",":","O","(","2",")","+","2","sulochrin","=","2","(","2R",")","-bisdechlorogeodin","+","2","H","(","2",")","O","."),4364789). assertion_content_comment('oboGo_SulochrinOxidaseBisdechlorogeodinFormingactivity',s("Catalysis","of","the","reaction",":","O","(","2",")","+","2","sulochrin","=","2","(","2S",")","-bisdechlorogeodin","+","2","H","(","2",")","O","."),4364800). assertion_content_comment('oboGo_SUMODependentproteincatabolicprocess',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4232959). assertion_content_comment('oboGo_SUMOSpecificendopeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","peptide","bonds","between","an","alpha-carboxyl","group","and","an","alpha-amino","group","within","the","small","conjugating","protein","SUMO","."),4179636). assertion_content_comment('oboGo_SUMOSpecificisopeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","an","isopeptide","bond","between","the","small","conjugating","protein","SUMO","and","a","protein","to","which","SUMO","has","been","conjugated","."),4179589). assertion_content_comment('oboGo_SUMOSpecificproteaseactivity',s("Catalysis","of","the","hydrolysis","of","SUMO",",","a","small","ubiquitin-related","modifier",",","from","previously","sumoylated","substrates","."),4179565). assertion_content_comment('oboGo_SUMOTargetedubiquitinligasecomplex',s("A","nuclear","ubiquitin","ligase","complex","that","specifically","targets","SUMOylated","proteins",";","the","complex","is","formed","of","homodimers","or","heterodimers","of","RNF4","family","ubiquitin","ligases","and","is","conserved","in","eukaryotes","."),4342161). assertion_content_comment('oboGo_SUNKashcomplex',s("A","protein","complex","that","spans","the","nuclear","outer","and","inner","membranes",",","thereby","linking","the","major","cytoplasmic","cytoskeleton","elements","to","the","nuclear","lumen",";","the","complex","is","conserved","in","eukaryotes","and","contains","proteins","with","SUN","and","KASH","domains","."),4072344). assertion_content_comment('oboGo_SuperoxideGeneratingnadphoxidaseactivatoractivity',s("Increases","the","activity","of","the","enzyme","superoxide-generating","NADPH","oxidase","."),4304039). assertion_content_comment('oboGo_SuperoxideGeneratingnadphoxidaseactivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","H","+","O2","=","NAD","(","P",")","H","+","O2-","."),4304093). assertion_content_comment('oboGo_SurfaceCoatOfCollagenAndCuticulinBasedcuticleextracellularmatrix',s("An","electron","dense",",","amorphous","envelope","that","comprises","the","outermost","layer","of","the","cuticle",".","The","surface","coat","is","loosely","apposed","to","the","epicuticle",",","has","distinct","biochemical","properties",",","is","synthesized","by","cells","other","than","the","underlying","hypodermis",",","and","is","labile",".","In","addition","to","serving","as","a","lubricant","to","protect","against","abrasion","and","dehydration",",","the","surface","coat","may","also","play","important","roles","in","infection","and","immune","evasion",".","An","example","of","this","component","is","found","in","Caenorhabditis","elegans","."),4108868). assertion_content_comment('oboGo_SUsnatereductaseactivity',s("Catalysis","of","the","reaction",":","(","6R",")","-2-acetyl-6-","(","3-acetyl-2",",","4",",","6-trihydroxy-5-methylphenyl",")","-3-hydroxy-6-methylcyclohexa-2",",","4-dien-1-one","+","NAD","(","+",")","=","(","S",")","-usnate","+","2","H","(","+",")","+","NADH","."),4361704). assertion_content_comment('oboGo_Swi5Sfr1complex',s("A","conserved","DNA","recombinase","mediator","complex","that","contains","two","Swi5","monomers","and","one","Sfr1","monomer","in","Schizosaccharomyces",",","or","orthologs","thereof","(","e.g",".","Sae3p","and","Mei5p","in","Saccharomyces",")"),4069028). assertion_content_comment('oboGo_Swi5Swi2complex',s("A","protein","complex","involved","that","contains","proteins","known","in","Schizosaccharomyces","as","Swi5","monomers","and","Swi2",",","and","is","involved","in","mating","type","switching","."),4073205). assertion_content_comment('oboGo_SWISNFTypecomplex',s("A","chromatin","remodeling","complex","that","contains","an","ortholog","of","the","Saccharomyces","ATPase","Swi2/Snf2","as","one","of","the","core","components","."),4169442). assertion_content_comment('oboGo_SymbiontContainingvacuolarmembranenetwork',s("Tubular","network","of","extensions","from","the","symbiont-containing","vacuole","membrane","that","protrude","into","the","host","cytoplasm","."),4041918). assertion_content_comment('oboGo_SymbiontContainingvacuolarspace',s("The","space","between","a","symbiont","plasma","membrane","and","the","symbiont-containing","vacuole","membrane","."),4042062). assertion_content_comment('oboGo_SymbiontContainingvacuolemembrane',s("The","lipid","bilayer","surrounding","a","symbiont-containing","vacuole",",","derived","from","both","the","host","and","symbiont","."),4041905). assertion_content_comment('oboGo_SymbiontContainingvacuole',s("Membrane-bounded","vacuole","within","a","host","cell","in","which","a","symbiont","organism","resides",".","The","vacuole","membrane","is","derived","from","both","the","host","and","symbiont","."),4041902). assertion_content_comment('oboGo_SymbiontEntryIntoHostCellFormingASymbiontContainingvacuole',s("The","invasion","by","a","symbiont","of","a","cell","of","its","host","organism",",","forming","a","vacuole","in","which","the","parasite","resides",".","The","vacuole","membrane","is","formed","from","lipids","and","proteins","derived","from","both","host","and","symbiont",".","Begins","when","the","symbiont","attaches","on","to","the","host","cell","membrane","which","invaginates","and","deepens","as","the","symbiont","enters",",","and","ends","when","the","host","cell","membrane","closes","behind","the","newly-formed","vacuole","."),4080286). assertion_content_comment('oboGo_SymNorspermidinesynthaseactivity',s("Catalysis","of","the","reaction",":","1",",","3-diaminopropane","+","S-adenosylmethioninamine","=","S-methyl-5","'","-thioadenosine","+","bis","(","3-aminopropyl",")","amine","+","H","(","+",")"),4265495). assertion_content_comment('oboGo_Synaptobrevin2_SNAP_25_Syntaxin_1a_ComplexinIComplex',s("A","SNARE","complex","that","contains","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","syntaxin","1a",",","and","complexin","I","(","or","orthologs","thereof",")"),4180377). assertion_content_comment('oboGo_Synaptobrevin2_SNAP_25_Syntaxin_1a_ComplexinIIComplex',s("A","SNARE","complex","that","contains","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","syntaxin","1a",",","and","complexin","II","(","or","orthologs","thereof",")"),4180599). assertion_content_comment('oboGo_Synaptobrevin2_SNAP_25_Syntaxin_1aComplex',s("A","SNARE","complex","that","contains","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","and","syntaxin","1a","(","or","orthologs","thereof",")"),4180698). assertion_content_comment('oboGo_Synaptobrevin2_SNAP_25_Syntaxin_2Complex',s("A","SNARE","complex","that","contains","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","and","syntaxin","2","(","or","orthologs","thereof",")"),4180711). assertion_content_comment('oboGo_Synaptobrevin2_SNAP_25_Syntaxin_3_ComplexinComplex',s("A","SNARE","complex","that","contains","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","syntaxin","3",",","and","a","complexin","(","or","orthologs","thereof",")"),4174629). assertion_content_comment('oboGo_Synaptobrevin2_SNAP_25_Syntaxin_3Complex',s("A","SNARE","complex","that","contains","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","and","syntaxin","3","(","or","orthologs","thereof",")"),4180722). assertion_content_comment('oboGo_Synaptobrevin2_SNAP_25_Syntaxin_4Complex',s("A","SNARE","complex","that","contains","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","and","syntaxin","4","(","or","orthologs","thereof",")"),4180733). assertion_content_comment('oboGo_Synaptotagmin_Synaptobrevin2_SNAP_25_Syntaxin_1a_Syntaxin_1b_Rab3a_ComplexinIIComplex',s("A","SNARE","complex","that","contains","synaptotagmin",",","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","syntaxin","1a",",","syntaxin1b",",","Rab3a",",","and","complexin","II","(","or","orthologs","thereof",")"),4173394). assertion_content_comment('oboGo_Synaptotagmin_Synaptobrevin2_SNAP_25_Syntaxin_1a_Syntaxin_1b_Rab3aComplex',s("A","SNARE","complex","that","contains","synaptotagmin",",","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","syntaxin","1a",",","syntaxin1b",",","and","Rab3a","(","or","orthologs","thereof",")"),4173405). assertion_content_comment('oboGo_Synaptotagmin_Synaptobrevin2_SNAP_25_Syntaxin_1a_Syntaxin_1b_Unc13Complex',s("A","SNARE","complex","that","contains","synaptotagmin",",","synaptobrevin","2","(","VAMP2",")",",","SNAP-25",",","syntaxin","1a",",","syntaxin1b",",","and","Unc13b","(","or","orthologs","thereof",")"),4176274). assertion_content_comment('oboGo_SynCopalyldiphosphatesynthaseactivity',s("Catalysis","of","the","reaction",":","geranylgeranyl","diphosphate","=","9alpha-copalyl","diphosphate","."),4286342). assertion_content_comment('oboGo_Syn_Pimara_715_DieneSynthaseActivity',s("Catalysis","of","the","reaction",":","9-alpha-copalyl","diphosphate","=","9-beta-pimara-7",",","15-diene","+","diphosphate","."),4360296). assertion_content_comment('oboGo_Syn_Stemod_1317_EneSynthaseActivity',s("Catalysis","of","the","reaction",":","9-alpha-copalyl","diphosphate","=","stemod-13","(","17",")","-ene","+","diphosphate","."),4360066). assertion_content_comment('oboGo_Syntaxin_13Binding',s("Interacting","selectively","and","non-covalently","with","the","SNAP","receptor","syntaxin-13","."),4309515). assertion_content_comment('oboGo_Syntaxin_1Binding',s("Interacting","selectively","and","non-covalently","with","the","SNAP","receptor","syntaxin-1","."),4269414). assertion_content_comment('oboGo_Syntaxin_2Binding',s("Interacting","selectively","and","non-covalently","with","the","SNAP","receptor","syntaxin-2","."),4309497). assertion_content_comment('oboGo_Syntaxin_3Binding',s("Interacting","selectively","and","non-covalently","with","the","SNAP","receptor","syntaxin-3","."),4309506). assertion_content_comment('oboGo_Syntaxin_5Binding',s("Interacting","selectively","and","non-covalently","with","the","SNAP","receptor","syntaxin-5","."),4283719). assertion_content_comment('oboGo_Syntaxin_6Binding',s("Interacting","selectively","and","non-covalently","with","the","SNAP","receptor","syntaxin-6","."),4266939). assertion_content_comment('oboGo_Syntaxin_6_Syntaxin_16_Vti1aComplex',s("A","SNARE","complex","that","contains","syntaxin","6",",","syntaxin","16",",","and","Vti1a","(","or","orthologs","thereof",")"),4180102). assertion_content_comment('oboGo_T2Induceddeoxynucleotidekinaseactivity',s("Catalysis","of","the","reactions",":","ATP","+","dGMP","=","ADP","+","dGDP",",","and","ATP","+","dTMP","=","ADP","+","dTDP","."),4265472). assertion_content_comment('oboGo_Tabersonine16Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADPH","+","O","(","2",")","+","tabersonine","=","16-hydroxytabersonine","+","H","(","2",")","O","+","NADP","(","+",")"),4267958). assertion_content_comment('oboGo_TAF4BContainingtranscriptionfactortfiidcomplex',s("A","transcription","factor","TFIID","complex","that","contains","the","TBP-associated","factor","TAF4B","(","also","known","as","TAFII105","in","human",")",",","a","cell-type-specific","variant","of","TAF4","."),4174619). assertion_content_comment('oboGo_Tagatose_6_PhosphateKinaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","D-tagatose","6-phosphate","=","ADP","+","D-tagatose","1",",","6-bisphosphate","."),4256767). assertion_content_comment('oboGo_TagatoseBisphosphatealdolaseactivity',s("Catalysis","of","the","reaction",":","D-tagatose","1",",","6-diphosphate","=","D-glyceraldehyde","3-phosphate","+","glycerone","phosphate","."),4256747). assertion_content_comment('oboGo_TailAnchoredmembraneproteininsertionintoermembrane',s("A","process","of","protein","insertion","into","the","endoplasmic","reticulum","(","ER",")","membrane","in","which","a","tail-anchored","(","TA",")","transmembrane","protein","is","incorporated","into","an","endoplasmic","reticulum","(","ER",")","membrane",".","TA","transmembrane","protein",",","also","named","type","II","transmembrane","proteins",",","contain","a","single","C-","terminal","transmembrane","region","."),4171036). assertion_content_comment('oboGo_TartronateOHydroxycinnamoyltransferaseactivity',s("Catalysis","of","the","reaction",":","hydroxymalonate","+","sinapoyl-CoA","=","CoA","+","sinapoyltartronate","."),4365263). assertion_content_comment('oboGo_TartronateSemialdehydesynthaseactivity',s("Catalysis","of","the","reaction",":","2","glyoxylate","+","H","(","+",")","=","2-hydroxy-3-oxopropanoate","+","CO","(","2",")"),4256699). assertion_content_comment('oboGo_TauProteinkinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","tau-protein","=","ADP","+","O-phospho-tau-protein","."),4265569). assertion_content_comment('oboGo_Taurine_2_OxoglutarateTransaminaseActivity',s("Catalysis","of","the","reaction",":","taurine","+","2-oxoglutarate","=","sulfoacetaldehyde","+","L-glutamate","."),4265596). assertion_content_comment('oboGo_TaurinePyruvateaminotransferaseactivity',s("Catalysis","of","the","reaction",":","pyruvate","+","taurine","=","L-alanine","+","sulfoacetaldehyde","."),4320139). assertion_content_comment('oboGo_TaurineTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","taurine","(","out",")","=","ADP","+","phosphate","+","taurine","(","in",")"),4291461). assertion_content_comment('oboGo_Taurochenodeoxycholate6alphaHydroxylaseactivity',s("Catalysis","of","the","reactions",":","taurochenodeoxycholate","+","NADPH","+","H","+","+","O2","=","taurohyocholate","+","NADP","+","+","H2O",",","and","lithocholate","+","NADPH","+","H","+","+","O2","=","hyodeoxycholate","+","NADP","+","+","H2O","."),4342096). assertion_content_comment('oboGo_Taxadien_5_Alpha_OlO_AcetyltransferaseActivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","taxa-4","(","20",")",",","11-dien-5alpha-ol","=","CoA","+","taxa-4","(","20",")",",","11-dien-5alpha-yl","acetate","."),4277742). assertion_content_comment('oboGo_Taxadiene5AlphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","AH","(","2",")","+","O","(","2",")","+","taxa-4",",","11-diene","=","A","+","H","(","2",")","O","+","taxa-4","(","20",")",",","11-dien-5alpha-ol","."),4278277). assertion_content_comment('oboGo_Taxane10BetaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADPH","+","O","(","2",")","+","taxa-4","(","20",")",",","11-dien-5alpha-yl","acetate","=","10beta-hydroxytaxa-4","(","20",")",",","11-dien-5alpha-yl","acetate","+","H","(","2",")","O","+","NADP","(","+",")"),4267774). assertion_content_comment('oboGo_Taxane13AlphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADPH","+","O","(","2",")","+","taxa-4","(","20",")",",","11-dien-5alpha-ol","=","H","(","2",")","O","+","NADP","(","+",")","+","taxa-4","(","20",")",",","11-dien-5alpha",",","13alpha-diol","."),4267814). assertion_content_comment('oboGo_Taxifolin8Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","taxifolin","+","NAD","(","P",")","H","+","H","+","+","O2","=","2",",","3-dihydrogossypetin","+","NAD","(","P",")","+","+","H2O","."),4265646). assertion_content_comment('oboGo_TBPClassproteinbindingrnapolymeraseiitranscriptionfactoractivityinvolvedinpreinitiationcomplexassembly',s("Interacting","selectively","and","non-covalently","with","a","member","of","the","class","of","TATA-binding","proteins","(","TBP",")",",","including","any","of","the","TBP-related","factors","(","TRFs",")",",","to","facilitate","the","aggregation",",","arrangement","and","bonding","together","of","proteins","on","RNA","polymerase","II","promoter","DNA","to","form","the","transcriptional","preinitiation","complex","(","PIC",")",",","the","formation","of","which","is","a","prerequisite","for","transcription","by","RNA","polymerase","."),4358406). assertion_content_comment('oboGo_TBPClassproteinbindingrnapolymeraseiitranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","member","of","the","class","of","TATA-binding","proteins","(","TBP",")",",","including","any","of","the","TBP-related","factors","(","TRFs",")",",","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","DNA","as","well","."),4358402). assertion_content_comment('oboGo_TBPClassproteinbinding',s("Interacting","selectively","and","non-covalently","with","a","member","of","the","class","of","TATA-binding","proteins","(","TBP",")",",","including","any","of","the","TBP-related","factors","(","TRFs",")"),4268715). assertion_content_comment('oboGo_TCellToleranceInductionInMucosalAssociatedlymphoidtissue',s("Tolerance","induction","taking","place","in","the","mucosal-associated","lymphoid","tissue","(","MALT",")","mediated","by","T","cells","."),4381369). assertion_content_comment('oboGo_Tea1CellEndcomplex',s("A","high","molecular","weight","complex","characterized","in","S",".","pombe","containing","the","cell-end","anchoring","protein","Tea1",".","This","complex","is","transported","to","the","cell","ends","by","microtubules","and","is","involved","in","bipolar","growth","and","the","maintennce","of","normal","cell","polarity","."),4060776). assertion_content_comment('oboGo_TEAD_1_YAPComplex',s("A","transcription","factor","complex","that","is","composed","of","the","DNA","biding","protein","TEAD-1","and","the","transcriptional","coactivator","YAP","."),4164814). assertion_content_comment('oboGo_TEAD_2MultiproteinComplex',s("A","protein","complex","that","consists","of","the","DNA","binding","protein","TEAD-2","bound","to","12","other","polypeptides","including","the","transcriptional","coactivator","YAP",",","the","multi-PDZ","domain","protein","MPDZ","(","also","called","MUPP1",")",",","a","14-3-3","domain","protein",",","and","others","."),4164843). assertion_content_comment('oboGo_TEAD_2_YAPComplex',s("A","transcription","factor","complex","that","is","composed","of","the","DNA","biding","protein","TEAD-2","and","the","transcriptional","coactivator","YAP","."),4164823). assertion_content_comment('oboGo_TEAD_3_YAPComplex',s("A","transcription","factor","complex","that","is","composed","of","the","DNA","biding","protein","TEAD-3","and","the","transcriptional","coactivator","YAP","."),4164916). assertion_content_comment('oboGo_TEAD_4_YAPComplex',s("A","transcription","factor","complex","that","is","composed","of","the","DNA","biding","protein","TEAD-4","and","the","transcriptional","coactivator","YAP","."),4164907). assertion_content_comment('oboGo_TeichoicAcidDAlanylation',s("The","formation","of","a","D-alanyl","ester","of","teichoic","acid",".","Alanylation","of","teichoic","acids","modulates","the","properties","of","the","bacterial","cell","wall","and","modulates","the","inflammatory","properties","of","the","teichoic","acid","."),4175561). assertion_content_comment('oboGo_TeichoicAcidTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","teichoic","acid","(","in",")","=","ADP","+","phosphate","+","teichoic","acid","(","out",")"),4292002). assertion_content_comment('oboGo_TelomereMaintenanceViaSemiConservativereplication',s("The","process","in","which","telomeric","DNA","is","synthesized","semi-conservatively","by","the","conventional","replication","machinery","and","telomeric","accessory","factors","."),4054079). assertion_content_comment('oboGo_TelomereTelomerasecomplex',s("A","complex","of","DNA","and","protein","located","at","the","end","of","a","linear","chromosome","that","enables","replication","of","the","telomeric","repeat","sequences","at","the","end","of","a","linear","chromosome","."),4131211). assertion_content_comment('oboGo_TemplateForSynthesisOfGRichstrandoftelomerednaactivity',s("Provision","of","the","template","used","by","reverse","transcriptase","to","synthesize","the","G-rich","strand","of","telomeric","DNA","."),3975029). assertion_content_comment('oboGo_Terephthalate12Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","NADH","+","O","(","2",")","+","terephthalate","=","(","3S",",","4R",")","-3",",","4-dihydroxycyclohexa-1",",","5-diene-1",",","4-dicarboxylate","+","NAD","(","+",")"),4276024). assertion_content_comment('oboGo_TerminalOGlycosylation',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4231121). assertion_content_comment('oboGo_TerminationOfRNAPolymeraseIITranscriptionExosomeDependent',s("The","process","in","which","transcription","of","nonpolyadenylated","RNA","polymerase","II","transcripts","is","terminated",";","coupled","to","the","maturation","of","the","RNA","3","'","-end","."),4307185). assertion_content_comment('oboGo_TerminationOfRNAPolymeraseIITranscriptionPolyACoupled',s("The","process","in","which","transcription","of","polyadenylated","RNA","polymerase","II","transcripts","is","terminated",";","cleavage","and","polyadenylylation","of","the","mRNA","3","'","end","is","coupled","to","transcription","termination","."),4307174). assertion_content_comment('oboGo_TerpenoidBiosyntheticProcessMevalonateDependent',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","terpenoids","via","isopentenyl","diphosphate",",","synthesized","by","the","mevalonate","pathway",".","Isopentenyl","diphosphate","(","IPP",")","is","the","fundamental","unit","in","terpenoid","biosynthesis",",","and","in","mevalonate-dependent","terpenoid","biosynthesis",",","acetate",",","in","the","form","of","acetyl-CoA",",","is","converted","to","isopentenyl","diphosphate","(","IPP",")","through","a","series","of","mevalonate","intermediates","."),4118902). assertion_content_comment('oboGo_TerpenoidBiosyntheticProcessMevalonateIndependent',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","terpenoids",",","independent","of","mevalonate",".","Isopentenyl","diphosphate","(","IPP",")","is","the","fundamental","unit","in","terpenoid","biosynthesis",",","and","in","mevalonate-independent","biosynthesis",",","it","is","produced","from","pyruvate","and","glyceraldehyde","3-phosphate","via","intermediates","including","1-deoxy-D-xylulose","5-phosphate","."),4119002). assertion_content_comment('oboGo_TertButylalcohol2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","tert-butyl","alcohol","+","1/2","O2","=","2-methyl-2-hydroxy-1-propanol","."),4275568). assertion_content_comment('oboGo_Testosterone15AlphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","testosterone","+","donor-H2","+","O2","=","15-alpha-hydroxytestosterone","+","H2O","."),4255554). assertion_content_comment('oboGo_Testosterone16AlphaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","testosterone","+","donor-H2","+","O2","=","6-alpha-hydroxytestosterone","+","H2O","."),4255648). assertion_content_comment('oboGo_Testosterone17BetaDehydrogenasenadactivity',s("Catalysis","of","the","reaction",":","testosterone","+","NAD","+","=","androst-4-ene-3",",","17-dione","+","NADH","."),4265657). assertion_content_comment('oboGo_Testosterone17BetaDehydrogenasenadpactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","testosterone","=","NADPH","+","H","+","+","androst-4-ene-3",",","17-dione","."),4364224). assertion_content_comment('oboGo_Testosterone6BetaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","testosterone","+","donor-H2","+","O2","=","6-beta-hydroxytestosterone","+","H2O","."),4277627). assertion_content_comment('oboGo_Tetraacyldisaccharide4Kinaseactivity',s("Catalysis","of","the","reaction",":","2",",","3-bis","(","3-hydroxytetradecanoyl",")","-D-glucosaminyl-","(","1-","&","gt",";","6",")","-beta-D-2",",","3-bis","(","3-hydroxytetradecanoyl",")","-beta-D-glucosaminyl","1-phosphate","+","ATP","=","ADP","+","2","H","(","+",")","+","lipid","IV","(","a",")"),4256687). assertion_content_comment('oboGo_TetrachloroPHydroquinonereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3",",","5",",","6-tetrachlorohydroquinone","+","2","glutathione","=","2",",","3",",","6-trichlorohydroquinone","+","glutathione","disulfide","+","HCl","."),4278930). assertion_content_comment('oboGo_Tetrahydrocolumbamine2OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-tetrahydrocolumbamine","+","S-adenosyl-L-methionine","(","1","+",")","=","S-adenosyl-L-homocysteine","+","H","(","+",")","+","tetrahydropalmatine","."),4308682). assertion_content_comment('oboGo_TetrahydrodipicolinateNAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","S",")","-2",",","3",",","4",",","5-tetrahydrodipicolinate","+","acetyl-CoA","+","H","(","2",")","O","=","L-2-acetamido-6-oxopimelate","+","CoA","."),4367752). assertion_content_comment('oboGo_TetrahydromethanopterinSMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","5-methyltetrahydromethanopterin","+","coenzyme","M","=","5",",","6",",","7",",","8-tetrahydromethanopterin","+","methyl-coenzyme","M",".","2-","(","methylthio",")","ethanesulfonate","is","also","known","as","methyl-CoM","."),4311998). assertion_content_comment('oboGo_Tetrahydrothiophene1Oxidereductaseactivity',s("Catalysis","of","the","reaction",":","tetrahydrothiophene","1-oxide","+","reduced","acceptor","=","tetrahydrothiophene","+","acceptor","."),4237776). assertion_content_comment('oboGo_TetralinRingHydroxylatingdioxygenaseactivity',s("Catalysis","of","the","reaction",":","tetralin","+","O2","+","NADH","+","H","+","=","cis-1",",","2-dihydroxy-1",",","2",",","5",",","6",",","7",",","8-hexahydronaphthalene","+","NAD","+"),4350593). assertion_content_comment('oboGo_TetrapyrroleBiosyntheticProcessFromGlycineAndSuccinylCoa',s("The","chemical","reactions","and","pathways","leading","to","the","formation","of","tetrapyrroles",",","natural","pigments","containing","four","pyrrole","rings","joined","by","one-carbon","units","linking","position","2","of","one","pyrrole","ring","to","position","5","of","the","next",",","from","other","compounds",",","including","glycine","and","succinyl-CoA","."),4340860). assertion_content_comment('oboGo_TFIIAClassbindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIA","class","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","DNA","as","well","."),4355684). assertion_content_comment('oboGo_TFIIAClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIA","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","by","RNA","polymerase","II","and","defined","as","a","basal","or","general","transcription","factor","."),4355532). assertion_content_comment('oboGo_TFIIBClassbindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIB","class","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","DNA","as","well","."),4355675). assertion_content_comment('oboGo_TFIIBClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIB","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","by","RNA","polymerase","II","and","defined","as","a","basal","or","general","transcription","factor","."),4355523). assertion_content_comment('oboGo_TFIIDClassbindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIID","class","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","DNA","as","well","."),4355666). assertion_content_comment('oboGo_TFIIDClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIID","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","by","RNA","polymerase","II","and","defined","as","a","basal","or","general","transcription","factor","."),4355514). assertion_content_comment('oboGo_TFIIEClassbindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIE","class","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","DNA","as","well","."),4355648). assertion_content_comment('oboGo_TFIIEClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIE","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","by","RNA","polymerase","II","and","defined","as","a","basal","or","general","transcription","factor","."),4355559). assertion_content_comment('oboGo_TFIIEClasstranscriptionfactorrecruitingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","(","RNAP","II",")","transcription","factor","of","the","TFIIE-class","in","order","to","recruit","it","to","the","RNAP","II","preinitiation","complex","(","PIC",")","in","order","to","modulate","transcription","by","RNAP","II","."),4358475). assertion_content_comment('oboGo_TFIIFClassbindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIF","class","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","DNA","as","well","."),4355629). assertion_content_comment('oboGo_TFIIFClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIF","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","by","RNA","polymerase","II","and","defined","as","a","basal","or","general","transcription","factor","."),4355550). assertion_content_comment('oboGo_TFIIFClasstranscriptionfactorrecruitingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","(","RNAP","II",")","transcription","factor","of","the","TFIIF-class","in","order","to","recruit","it","to","the","RNAP","II","preinitiation","complex","(","PIC",")","in","order","to","modulate","transcription","by","RNAP","II","."),4358465). assertion_content_comment('oboGo_TFIIHClassbindingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIH","class","in","order","to","modulate","transcription",".","The","transcription","factor","may","or","may","not","also","interact","selectively","with","DNA","as","well","."),4355586). assertion_content_comment('oboGo_TFIIHClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","transcription","factor","of","the","TFIIH","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","by","RNA","polymerase","II","and","defined","as","a","basal","or","general","transcription","factor","."),4355541). assertion_content_comment('oboGo_TFIIHClasstranscriptionfactorrecruitingtranscriptionfactoractivity',s("Interacting","selectively","and","non-covalently","with","a","basal","RNA","polymerase","II","(","RNAP","II",")","transcription","factor","of","the","TFIIH-class","in","order","to","recruit","it","to","the","RNAP","II","preinitiation","complex","(","PIC",")","in","order","to","modulate","transcription","by","RNAP","II","."),4358503). assertion_content_comment('oboGo_TFIIIAClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","an","RNA","polymerase","III","transcription","factor","of","the","TFIIIA","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","at","type","1","promoters","(","5S","genes",")","by","RNA","polymerase","III","."),4357930). assertion_content_comment('oboGo_TFIIIBClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","an","RNA","polymerase","III","transcription","factor","of","the","TFIIIB","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","by","RNA","polymerase","III","."),4357921). assertion_content_comment('oboGo_TFIIIBTypetranscriptionfactoractivity',s("Once","recruited","to","an","RNA","polymerase","III","promoter","by","one","or","more","other","transcription","factors",",","binds","to","DNA",",","recruits","RNA","polymerase","III","and","facilitates","the","transition","from","the","closed","to","the","open","complex","."),4356295). assertion_content_comment('oboGo_TFIIICClasstranscriptionfactorbinding',s("Interacting","selectively","and","non-covalently","with","an","RNA","polymerase","III","transcription","factor","of","the","TFIIIC","class",",","one","of","the","factors","involved","in","formation","of","the","preinitiation","complex","(","PIC",")","by","RNA","polymerase","III","."),4357939). assertion_content_comment('oboGo_TFIIICTop1Sub1complex',s("A","protein","complex","that","contains","TFIIIC",",","topoisomerase","1",",","and","Sub1/PC4",".","Characterized","in","human",",","the","complex","is","involved","in","regulating","transcription","from","RNA","polymerase","III","(","Pol","III",")","promoters",".","Topoisomerase","1","and","Sub1","enhance","the","accuracy","of","transcription","termination",",","and","promote","reinitiation","by","Pol","III","."),4073439). assertion_content_comment('oboGo_TGMismatchSpecificendonucleaseactivity',s("Catalysis","of","the","repair","of","T/G","mismatches","arising","from","deamination","of","5-methylcytosine","in","DNA","by","nicking","double-stranded","DNA","within","the","sequence","CT","(","AT",")","GN","or","NT","(","AT",")","GG","next","to","the","mismatched","thymidine","residue",".","The","incision","is","mismatch-dependent","and","strand-specific",",","in","favor","of","the","G-containing","strand",".","The","incision","serves","as","a","starting","point","for","subsequent","excision","repair","by","DNA","polymerase","I",",","which","excises","thymidine","and","reinserts","cytidine","."),4327878). assertion_content_comment('oboGo_ThalianDioldesaturaseactivity',s("Catalysis","of","the","reaction",":","a","thalian-diol","=","a","desaturated","thalian-diol",".","This","reaction","is","the","introduction","of","a","double","bond","to","a","thalian-diol","molecule","at","carbon","15","."),4182883). assertion_content_comment('oboGo_THelper17cellchemotaxis',s("The","directed","movement","of","a","T-helper","17","cell","in","response","to","an","external","stimulus","."),4381026). assertion_content_comment('oboGo_THelper17celldifferentiation',s("The","process","in","which","a","relatively","unspecialized","T","cell","acquires","the","specialized","features","of","a","T-helper","17","(","Th17",")","cell",".","A","Th17","cell","is","a","CD4-positive",",","alpha-beta","T","cell","with","the","phenotype","RORgamma-t-positive","that","produces","IL-17","."),4126072). assertion_content_comment('oboGo_THelper17cellextravasation',s("The","migration","of","a","T-helper","17","cell","from","the","blood","vessels","into","the","surrounding","tissue","."),4142140). assertion_content_comment('oboGo_THelper17celllineagecommitment',s("The","process","in","which","a","CD4-positive",",","alpha-beta","T","cell","becomes","committed","to","becoming","a","T-helper","17","cell",",","a","CD4-positive",",","alpha-beta","T","cell","with","the","phenotype","RORgamma-t-positive","that","produces","IL-17","."),4126083). assertion_content_comment('oboGo_THelper17typeimmuneresponse',s("An","immune","response","which","is","associated","with","resistance","to","intracellular","bacteria","with","a","key","role","in","inflammation","and","tissue","injury",".","This","immune","response","is","associated","with","pathological","autoimmune","conditions","such","as","multiple","sclerosis",",","arthritis","and","psoriasis","which","is","typically","orchestrated","by","the","production","of","particular","cytokines","by","T-helper","17","cells",",","most","notably","interleukin-17",",","IL-21","and","IL-22","."),4126060). assertion_content_comment('oboGo_THelper1cellactivation',s("The","change","in","morphology","and","behavior","of","a","T-helper","1","cell","resulting","from","exposure","to","a","mitogen",",","cytokine",",","chemokine",",","cellular","ligand",",","or","an","antigen","for","which","it","is","specific","."),4144808). assertion_content_comment('oboGo_THelper1cellchemotaxis',s("The","directed","movement","of","a","T-helper","1","cell","in","response","to","an","external","stimulus","."),4380996). assertion_content_comment('oboGo_THelper1cellcytokineproduction',s("Any","process","that","contributes","to","cytokine","production","by","a","T-helper","1","cell","."),4082443). assertion_content_comment('oboGo_THelper1celldiapedesis',s("The","passage","of","a","T-helper","1","cell","between","the","tight","junctions","of","endothelial","cells","lining","blood","vessels",",","typically","the","fourth","and","final","step","of","cellular","extravasation",".","A","T-helper","1","cell","is","a","CD4-positive",",","alpha-beta","T","cell","that","has","the","phenotype","T-bet-positive","and","produces","interferon-gamma","."),4082815). assertion_content_comment('oboGo_THelper1celldifferentiation',s("The","process","in","which","a","relatively","unspecialized","T","cell","acquires","the","specialized","features","of","a","T-helper","1","(","Th1",")","cell",".","A","Th1","cell","is","a","CD4-positive",",","alpha-beta","T","cell","that","has","the","phenotype","T-bet-positive","and","produces","interferon-gamma","."),3992618). assertion_content_comment('oboGo_THelper1cellextravasation',s("The","migration","of","a","T-helper","1","cell","from","the","blood","vessels","into","the","surrounding","tissue",".","A","T-helper","1","cell","is","a","CD4-positive",",","alpha-beta","T","cell","that","has","the","phenotype","T-bet-positive","and","produces","interferon-gamma","."),4082781). assertion_content_comment('oboGo_THelper1celllineagecommitment',s("The","process","in","which","a","CD4-positive",",","alpha-beta","T","cell","becomes","committed","to","becoming","a","T-helper","1","cell",",","a","CD4-positive",",","alpha-beta","T","cell","specialized","to","promote","immunological","processes","often","associated","with","resistance","to","intracellular","bacteria",",","fungi",",","and","protozoa",",","and","pathological","conditions","such","as","arthritis","."),3992629). assertion_content_comment('oboGo_THelper1typeimmuneresponse',s("An","immune","response","which","is","associated","with","resistance","to","intracellular","bacteria",",","fungi",",","and","protozoa",",","and","pathological","conditions","such","as","arthritis",",","and","which","is","typically","orchestrated","by","the","production","of","particular","cytokines","by","T-helper","1","cells",",","most","notably","interferon-gamma",",","IL-2",",","and","lymphotoxin","."),3992615). assertion_content_comment('oboGo_THelper2cellactivation',s("The","change","in","morphology","and","behavior","of","a","T","helper","2","cell","resulting","from","exposure","to","a","mitogen",",","cytokine",",","chemokine",",","cellular","ligand",",","or","an","antigen","for","which","it","is","specific","."),4144191). assertion_content_comment('oboGo_THelper2cellchemotaxis',s("The","directed","movement","of","a","T-helper","2","cell","in","response","to","an","external","stimulus","."),4381006). assertion_content_comment('oboGo_THelper2cellcytokineproduction',s("Any","process","that","contributes","to","cytokine","production","by","a","T-helper","2","cell","."),4082432). assertion_content_comment('oboGo_THelper2celldifferentiation',s("The","process","in","which","a","relatively","unspecialized","T","cell","acquires","specialized","features","of","a","T-helper","2","(","Th2",")","cell",".","A","Th2","cell","is","a","CD4-positive",",","alpha-beta","T","cell","that","has","the","phenotype","GATA-3-positive","and","produces","interleukin-4","."),3992558). assertion_content_comment('oboGo_THelper2celllineagecommitment',s("The","process","in","which","a","CD4-positive",",","alpha-beta","T","cell","becomes","committed","to","becoming","a","T-helper","2","cell",",","a","CD4-positive",",","alpha-beta","T","cell","specialized","to","promote","immunological","processes","often","associated","with","resistance","to","extracellular","organisms","such","as","helminths",",","enhanced","production","of","particular","antibody","isotypes",",","and","pathological","conditions","such","as","allergy","."),3992595). assertion_content_comment('oboGo_THelpercelldifferentiation',s("The","process","in","which","a","relatively","unspecialized","thymocyte","acquires","specialized","features","of","a","T-helper","cell","."),3992542). assertion_content_comment('oboGo_THelpercelllineagecommitment',s("The","process","in","which","a","CD4-positive",",","alpha-beta","T","cell","becomes","committed","to","becoming","a","T-helper","cell",",","a","CD4-positive",",","alpha-beta","T","cell","specialized","to","promote","various","immunological","processes","."),3992589). assertion_content_comment('oboGo_ThetinHomocysteinesMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","L-homocysteine","+","dimethylsulfonioacetate","=","(","methylthio",")","acetate","+","L-methionine","+","H","(","+",")"),4365484). assertion_content_comment('oboGo_ThiamineContainingcompoundbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","thiamine","(","vitamin","B1",")",",","and","related","compounds","."),4130819). assertion_content_comment('oboGo_ThiamineContainingcompoundcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","thiamine","(","vitamin","B1",")",",","and","compounds","derived","from","it","."),4257453). assertion_content_comment('oboGo_ThiamineContainingcompoundmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","thiamine","(","vitamin","B1",")",",","and","compounds","derived","from","it","."),4130784). assertion_content_comment('oboGo_ThiamineDiphosphatekinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","thiamin","diphosphate","=","ADP","+","thiamin","triphosphate","."),4265539). assertion_content_comment('oboGo_ThiaminePhosphatediphosphorylaseactivity',s("Catalysis","of","the","reaction",":","4-amino-2-methyl-5-diphosphomethylpyrimidine","+","4-methyl-5-","(","2-phosphoethyl",")","-thiazole","+","H","(","+",")","=","diphosphate","+","thiamine","phosphate","."),4201959). assertion_content_comment('oboGo_ThiaminePhosphatekinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","thiamine","phosphate","=","ADP","+","H","(","+",")","+","thiamine","diphosphate","."),4256945). assertion_content_comment('oboGo_ThiaminePyrophosphataseactivity',s("Catalysis","of","the","reaction",":","TDP","+","H2O","=","TMP","+","phosphate","."),4201868). assertion_content_comment('oboGo_ThiaminePyrophosphateTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","thiamine","pyrophosphate","(","out",")","=","ADP","+","phosphate","+","thiamine","pyrophosphate","(","in",")"),4289348). assertion_content_comment('oboGo_ThiamineTransportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","thiamine","(","out",")","=","ADP","+","phosphate","+","thiamine","(","in",")"),4331048). assertion_content_comment('oboGo_ThiaminTriphosphataseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","thiamine","triphosphate","=","H","(","+",")","+","phosphate","+","thiamine","diphosphate","."),4264867). assertion_content_comment('oboGo_ThioacetamideSOxidesOxygenaseactivity',s("Catalysis","of","the","reaction",":","thioacetamide","S-oxide","+","O2","+","2","H","+","+","2","e-","=","thioacetamide","S",",","S-dioxide","+","H2O","."),4350974). assertion_content_comment('oboGo_ThioacetamideSOxygenaseactivity',s("Catalysis","of","the","reaction",":","thioacetamide","+","O2","+","2","H","+","+","2","e-","=","thioacetamide","S-oxide","+","H2O","."),4350965). assertion_content_comment('oboGo_ThioethanolamineSAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","cysteamine","=","S-acetylcysteamine","+","CoA","."),4264825). assertion_content_comment('oboGo_ThioetherSMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","+","dimethyl","sulfide","=","S-adenosyl-L-homocysteine","+","trimethylsulfonium","."),4202199). assertion_content_comment('oboGo_ThiohydroximateBetaDGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","phenylthioacetohydroximate","+","UDP-D-glucose","=","desulfoglucotropeolin","+","UDP","."),4367199). assertion_content_comment('oboGo_ThiolDisulfideexchangeintermediateactivity',s("OBSOLETE",".","Functions","as","an","exchange","intermediate","in","thiol-disulfide","exchange","reactions","."),4310870). assertion_content_comment('oboGo_ThiolDrivenfumaratereductaseactivity',s("Catalysis","of","the","reaction",":","fumarate","+","coenzyme","M","+","coenzyme","B","=","succinate","+","coenzyme","M","+","coenzyme","B","+","heterodisulfide","."),4327099). assertion_content_comment('oboGo_ThiolSMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","a","thiol","=","S-adenosyl-L-homocysteine","+","a","thioether","."),4275207). assertion_content_comment('oboGo_ThiomorpholineCarboxylatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","NAD","(","P",")","+","+","thiomorpholine-3-carboxylate","=","NAD","(","P",")","H","+","3",",","4-dehydro-1",",","4-thiomorpholine-3-carboxylate","."),4365755). assertion_content_comment('oboGo_Thiophene_2_Carbonyl_CoAMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","AH","(","2",")","+","O","(","2",")","+","thiophene-2-carbonyl-CoA","=","5-hydroxythiophene-2-carbonyl-CoA","+","A","+","H","(","2",")","O","+","H","(","+",")"),4278238). assertion_content_comment('oboGo_Thiophene_2_Carboxylate_CoALigaseActivity',s("Catalysis","of","the","reaction",":","thiophene-2-carboxylate","+","ATP","+","CoASH","=","thiophene-2-carboxyl-CoA","+","AMP","+","PPi","."),4350702). assertion_content_comment('oboGo_ThiopurineSMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","a","thiopurine","=","S-adenosyl-L-homocysteine","+","a","thiopurine","S-methylether","."),4246363). assertion_content_comment('oboGo_ThioredoxinDisulfidereductaseactivity',s("Catalysis","of","the","reaction",":","NADP","(","+",")","+","thioredoxin","=","H","(","+",")","+","NADPH","+","thioredoxin","disulfide","."),4202241). assertion_content_comment('oboGo_Thioredoxin_Like2Fe_2SFerredoxin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4259405). assertion_content_comment('oboGo_ThiosulfateDithiolsulfurtransferaseactivity',s("Catalysis","of","the","reaction",":","dithioerythritol","+","thiosulfate","=","hydrogen","sulfide","+","dithioerythritol","disulfide","+","sulfite","."),4367833). assertion_content_comment('oboGo_ThiosulfateThiolsulfurtransferaseactivity',s("Catalysis","of","the","reaction",":","thiosulfate","+","2","glutathione","=","sulfite","+","glutathione","disulfide","+","sulfide","."),4264811). assertion_content_comment('oboGo_ThiosulfateTransmembraneTransportingatpaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","ATP","+","H2O","+","thiosulfate","(","out",")","=","ADP","+","phosphate","+","thiosulfate","(","in",")"),4329138). assertion_content_comment('oboGo_Threo_3_HydroxyaspartateAmmonia_LyaseActivity',s("Catalysis","of","the","reaction",":","(","3S",")","-3-hydroxy-L-aspartate","=","NH","(","4",")","(","+",")","+","oxaloacetate","."),4307150). assertion_content_comment('oboGo_ThreonineCatabolicProcessToAcetylCoa',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","threonine","(","2-amino-3-hydroxybutyric","acid",")","to","form","the","compound","acetyl-Coenzyme","A","."),4177228). assertion_content_comment('oboGo_ThreonineCatabolicProcessToDLactate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","threonine","(","2-amino-3-hydroxybutyric","acid",")","to","form","the","compound","methylglyoxal",",","which","is","subsequently","converted","to","D-lactate","."),4242276). assertion_content_comment('oboGo_ThreoninePhosphatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","O-phospho-L-threonine","+","H","(","+",")","=","(","R",")","-1-aminopropan-2-yl","phosphate","+","CO","(","2",")"),4335795). assertion_content_comment('oboGo_ThreonineTrnaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","L-threonine","+","tRNA","(","Thr",")","=","AMP","+","diphosphate","+","L-threonyl-tRNA","(","Thr",")"),4199760). assertion_content_comment('oboGo_ThreonineTypeendopeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","internal","peptide","bonds","in","a","polypeptide","chain","by","a","mechanism","in","which","the","hydroxyl","group","of","a","threonine","residue","at","the","active","center","acts","as","a","nucleophile","."),4209713). assertion_content_comment('oboGo_ThreonineTypepeptidaseactivity',s("Catalysis","of","the","hydrolysis","of","peptide","bonds","in","a","polypeptide","chain","by","a","mechanism","in","which","the","hydroxyl","group","of","a","threonine","residue","at","the","active","center","acts","as","a","nucleophile","."),4180784). assertion_content_comment('oboGo_ThreonylTrnaaminoacylation',s("The","process","of","coupling","threonine","to","threonyl-tRNA",",","catalyzed","by","threonyl-tRNA","synthetase",".","In","tRNA","aminoacylation",",","the","amino","acid","is","first","activated","by","linkage","to","AMP","and","then","transferred","to","either","the","2","'","-","or","the","3","'","-hydroxyl","group","of","the","3","'","-adenosine","residue","of","the","tRNA","."),4179546). assertion_content_comment('oboGo_ThromboxaneAsynthaseactivity',s("Catalysis","of","the","reaction",":","prostaglandin","H","(","2",")","=","thromboxane","A","(","2",")"),4202084). assertion_content_comment('oboGo_ThylakoidLightHarvestingcomplex',s("A","thylakoid","membrane","complex","of","chlorophylls","a","and","b","together","with","chlorophyll","a-b","binding","proteins",".","In","addition",",","LHCs","contain","a","number","of","other","proteins",",","the","function","of","which","is","speculative",",","together","with","accessory","pigments",".","The","LHCs","capture","and","transfer","energy","to","photosystems","I","and","II",".","An","example","of","this","is","found","in","Arabidopsis","thaliana","."),4022762). assertion_content_comment('oboGo_ThymidineTriphosphataseactivity',s("Catalysis","of","the","reaction",":","dTTP","+","H2O","=","dTDP","+","phosphate","."),4264838). assertion_content_comment('oboGo_Thymidylate5Phosphataseactivity',s("Catalysis","of","the","reaction",":","thymidylate","+","H2O","=","thymidine","+","phosphate","."),4264919). assertion_content_comment('oboGo_ThyroidHormonetransaminaseactivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","3",",","5",",","3","'","-triiodo-L-thyronine","=","3",",","5",",","3","'","-triiodothyropyruvate","+","L-glutamate","."),4343815). assertion_content_comment('oboGo_ThyroidStimulatinghormonereceptoractivity',s("Combining","with","thyroid-stimulating","hormone","to","initiate","a","change","in","cell","activity","."),4199021). assertion_content_comment('oboGo_ThyroidStimulatinghormoneSecretingcelldevelopment',s("The","process","whose","specific","outcome","is","the","progression","of","a","thyroid-stimulating","hormone-secreting","cell","over","time",",","from","its","formation","to","the","mature","structure",".","A","thyroid-stimulating","hormone-secreting","cell","is","a","basophil","cell","of","the","anterior","pituitary","that","produces","thyroid","stimulating","hormone",",","thyrotrophin","."),4107926). assertion_content_comment('oboGo_ThyroidStimulatinghormoneSecretingcelldifferentiation',s("The","process","in","which","a","relatively","unspecialized","cell","acquires","specialized","structural","and/or","functional","features","of","a","thyroid-stimulating","hormone-secreting","cell",".","A","thyroid-stimulating","hormone-secreting","cell","is","a","basophil","cell","of","the","anterior","pituitary","that","produces","thyroid-stimulating","hormone",",","thyrotrophin","."),4107911). assertion_content_comment('oboGo_ThyroidStimulatinghormonesecretion',s("The","regulated","release","of","thyroid-stimulating","hormone",",","a","peptide","hormone","that","stimulates","the","activity","of","the","thyroid","gland",",","from","secretory","granules","in","the","anterior","pituitary","."),4143630). assertion_content_comment('oboGo_ThyrotropinReleasinghormoneactivity',s("The","action","characteristic","of","thyrotropin-releasing","hormone","(","TRH",")",",","a","hormone","released","by","the","mammalian","hypothalamus","into","the","hypophyseal-portal","circulation","in","response","to","neural","and/or","chemical","stimuli",".","Upon","receptor","binding",",","TRH","increases","the","secretion","of","thyroid-stimulating","hormone","by","the","anterior","pituitary","."),4253692). assertion_content_comment('oboGo_ThyrotropinReleasingHormoneAndSecretagogueLikereceptorsactivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383584). assertion_content_comment('oboGo_ThyrotropinReleasinghormonebinding',s("Interacting","selectively","and","non-covalently","with","thyrotropin-releasing","hormone",",","a","tripeptide","hormone","that","stimulates","the","release","of","thyroid-stimulating","hormone","(","TSH",")","and","prolactin","by","the","anterior","pituitary","and","it","is","produced","by","the","hypothalamus","and","travels","across","the","median","eminence","to","the","pituitary","via","the","pituitary","portal","system","."),4286569). assertion_content_comment('oboGo_ThyrotropinReleasinghormonereceptoractivity',s("Combining","with","thyrotropin-releasing","hormone","to","initiate","a","change","in","cell","activity","."),4199033). assertion_content_comment('oboGo_ThyrotropinReleasinghormonereceptorbinding',s("Interacting","selectively","and","non-covalently","with","a","receptor","for","thyrotropin-releasing","hormone",",","a","tripeptide","hormone","that","is","produced","by","the","hypothalamus","and","stimulates","the","release","of","thyroid-stimulating","hormone","(","TSH",")","and","prolactin","by","the","anterior","pituitary","."),4321950). assertion_content_comment('oboGo_Thyroxine5_DeiodinaseActivity_5',s("Catalysis","of","the","reaction",":","3",",","3","'",",","5","'","-triiodo-L-thyronine","+","iodide","+","A","+","H","+","=","L-thyroxine","+","AH2","."),4342360). assertion_content_comment('oboGo_Thyroxine5Deiodinaseactivity',s("Catalysis","of","the","reaction",":","3",",","5",",","3","'","-L-triiodo-L-thyronine","+","iodide","+","acceptor","+","H","+","=","L-thyroxine","+","donor-H2","."),4199294). assertion_content_comment('oboGo_TIRAPDependenttollLikereceptor4signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","toll-like","receptor","4","where","the","TIRAP/MAL","adaptor","mediates","transduction","of","the","signal",".","Toll-like","4","receptors","are","pattern","recognition","receptors","that","bind","bacterial","lipopolysaccharide","(","LPS",")","to","initiate","an","innate","immune","response","."),4380125). assertion_content_comment('oboGo_TIRAPDependenttollLikereceptorsignalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","toll-like","receptor","where","the","TIRAP/MAL","adaptor","mediates","transduction","of","the","signal",".","Toll-like","receptors","directly","bind","pattern","motifs","from","a","variety","of","microbial","sources","to","initiate","innate","immune","response","."),4380111). assertion_content_comment('oboGo_TIRDomainMediatedcomplexassembly',s("A","process","of","protein","complex","assembly","in","which","the","arrangement","and","bonding","together","of","the","set","of","components","that","form","the","protein","complex","is","mediated","by","a","TIR","domain","interaction","."),4172138). assertion_content_comment('oboGo_TissueKallikreinKinincascade',s("A","series","of","reactions","that","takes","place","outside","the","cell","initiated","by","the","action","of","tissue","(","glandular",")","kallikreins","on","low","molecular","weight","kininogen","in","response","to","tissue","damage",".","Tissue","kallikreins","are","present","in","glandular","tissues","and","their","fluids",",","such","as","the","salivary","glands",",","sweat","glands",",","pancreas",",","and","kidney",".","The","ultimate","products","of","the","tissue","kallikrein-kinin","cascade","include","kallidin","and","bradykinin",",","agents","known","to","induce","smooth","muscle","contraction",",","vasoconstriction",",","and","increased","vascular","permeability","."),3994300). assertion_content_comment('oboGo_Tle3Aescomplex',s("A","transcriptional","repressor","complex","that","consists","of","a","heterodimer","of","the","proteins","Tle3","(","also","known","as","Grg3b",")","and","Aes","(","Grg5",")",",","which","are","homologs","of","the","Drosophila","groucho","gene","product","."),4176612). assertion_content_comment('oboGo_TNFSF11Mediatedsignalingpathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","TNFSF11","binding","to","a","cell","surface","receptor","."),4171021). assertion_content_comment('oboGo_TocopherolOMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","gamma-tocopherol","=","S-adenosyl-L-homocysteine","+","alpha-tocopherol","."),4264950). assertion_content_comment('oboGo_ToleranceInductionInGutAssociatedlymphoidtissue',s("Tolerance","induction","taking","place","in","the","gut-associated","lymphoid","tissue","(","GALT",")"),4379373). assertion_content_comment('oboGo_ToleranceInductionInMucosalAssociatedlymphoidtissue',s("Tolerance","induction","taking","place","in","the","mucosal-associated","lymphoid","tissue","(","MALT",")"),4379370). assertion_content_comment('oboGo_ToleranceInductionInNasopharyngealAssociatedlymphoidtissue',s("Tolerance","induction","taking","place","in","the","nasopharyngeal-associated","lymphoid","tissue","(","NALT",")"),4381357). assertion_content_comment('oboGo_TollLikereceptor10signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","10","."),4075927). assertion_content_comment('oboGo_TollLikereceptor11signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","11","."),4075850). assertion_content_comment('oboGo_TollLikereceptor12signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","12","."),4075814). assertion_content_comment('oboGo_TollLikereceptor13signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","13","."),4076095). assertion_content_comment('oboGo_TollLikereceptor15signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","15","."),4141921). assertion_content_comment('oboGo_TollLikereceptor1signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","1","."),4076948). assertion_content_comment('oboGo_TollLikereceptor1TollLikereceptor2proteincomplex',s("A","heterodimeric","protein","complex","containing","Toll-like","receptor","1","(","TLR1",")","and","Toll-like","receptor","2","(","TLR2",")"),4383101). assertion_content_comment('oboGo_TollLikereceptor21signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","21","."),4142379). assertion_content_comment('oboGo_TollLikereceptor2binding',s("Interacting","selectively","and","non-covalently","with","a","Toll-like","2","protein",",","a","pattern","recognition","receptor","that","binds","microbial","pattern","motifs","to","initiate","an","innate","immune","response","."),4380101). assertion_content_comment('oboGo_TollLikereceptor2signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","2","."),4076206). assertion_content_comment('oboGo_TollLikereceptor2TollLikereceptor6proteincomplex',s("A","heterodimeric","protein","complex","containing","Toll-like","receptor","2","(","TLR2",")","and","Toll-like","receptor","6","(","TLR6",")"),4383132). assertion_content_comment('oboGo_TollLikereceptor3signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","3","."),4076170). assertion_content_comment('oboGo_TollLikereceptor4binding',s("Interacting","selectively","and","non-covalently","with","a","Toll-like","4","protein",",","a","pattern","recognition","receptor","that","binds","bacterial","lipopolysaccharide","(","LPS",")","to","initiate","an","innate","immune","response","."),4380091). assertion_content_comment('oboGo_TollLikereceptor4signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","4","."),4076255). assertion_content_comment('oboGo_TollLikereceptor5signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","5","."),4076304). assertion_content_comment('oboGo_TollLikereceptor6signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","6","."),4076340). assertion_content_comment('oboGo_TollLikereceptor7signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","7","."),4076376). assertion_content_comment('oboGo_TollLikereceptor8signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","8","."),4076513). assertion_content_comment('oboGo_TollLikereceptor9signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","toll-like","receptor","9","."),4076451). assertion_content_comment('oboGo_TollLikereceptorbinding',s("Interacting","selectively","and","non-covalently","with","a","Toll-like","protein",",","a","pattern","recognition","receptor","that","binds","pattern","motifs","from","a","variety","of","microbial","sources","to","initiate","an","innate","immune","response","."),4380088). assertion_content_comment('oboGo_TollLikereceptorsignalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","toll-like","receptor",".","Toll-like","receptors","directly","bind","pattern","motifs","from","a","variety","of","microbial","sources","to","initiate","innate","immune","response","."),4075810). assertion_content_comment('oboGo_Toluene2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","toluene","+","1/2","O2","=","2-hydroxytoluene","."),4276278). assertion_content_comment('oboGo_Toluene3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","toluene","+","1/2","O2","=","3-hydroxytoluene","."),4276173). assertion_content_comment('oboGo_Toluene4Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","toluene","+","1/2","O2","=","4-hydroxytoluene","."),4275895). assertion_content_comment('oboGo_Toluene_4_SulfonateBiosyntheticProcess',s("OBSOLETE",".","The","chemical","reactions","and","pathways","resulting","in","the","formation","of","toluene-4-sulfonate",",","4-methylbenzenesulfonate",",","the","anion","of","sulfonic","acid","attached","to","a","methylbenzene","molecule","."),4353197). assertion_content_comment('oboGo_Toluene_4_SulfonateCatabolicProcess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","toluene-4-sulfonate",",","4-methylbenzenesulfonate",",","the","anion","of","sulfonic","acid","attached","to","a","methylbenzene","molecule","."),4353163). assertion_content_comment('oboGo_Toluene_4_SulfonateMetabolicProcess',s("The","chemical","reactions","and","pathways","involving","toluene-4-sulfonate",",","the","anion","of","4-toluene","sulfonic","acid",",","a","white","crystalline","solid","which","is","highly","hygroscopic","and","soluble","in","water","."),4272614). assertion_content_comment('oboGo_Toluene_4_SulfonateMonooxygenaseActivity',s("Catalysis","of","the","reaction",":","toluene-4-sulfonate","+","1/2","O2","+","H","+","=","HSO3","(","-",")","+","4-hydroxytoluene","."),4276221). assertion_content_comment('oboGo_TolueneContainingcompoundcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","toluene",",","methylbenzene","(","formula","C7H8",")",",","or","any","of","its","derivatives","."),4156660). assertion_content_comment('oboGo_TolueneContainingcompoundmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","toluene",",","methylbenzene","(","formula","C7H8",")",",","or","any","of","its","derivatives","."),4156632). assertion_content_comment('oboGo_TolueneOxidationVia2Hydroxytoluene',s("The","degradation","of","toluene","to","form","pyruvate","and","acetaldehyde",";","the","first","step","in","the","pathway","is","the","oxidation","of","toluene","to","form","2-hydroxytoluene","(","o-cresol",")"),4243545). assertion_content_comment('oboGo_TolueneOxidationVia3Hydroxytoluene',s("The","degradation","of","toluene","to","form","pyruvate","and","acetaldehyde",";","the","first","step","in","the","pathway","is","the","oxidation","of","toluene","to","form","3-hydroxytoluene","(","m-cresol",")"),4243535). assertion_content_comment('oboGo_TolueneOxidationVia4Hydroxytoluene',s("The","degradation","of","toluene","to","form","p-hydroxybenzoate",";","the","first","step","in","the","pathway","is","the","oxidation","of","toluene","to","form","4-hydroxytoluene","(","4-cresol",")"),4243525). assertion_content_comment('oboGo_TolueneOxidationViaToluene_Cis_12_Dihydrodiol',s("The","degradation","of","toluene","to","form","pyruvate","and","acetaldehyde",";","the","first","step","in","the","pathway","is","the","oxidation","of","toluene","to","form","toluene-cis-1",",","2-dihydrodiol","."),4244573). assertion_content_comment('oboGo_TolueneSulfonatemethylMonooxygenaseactivity',s("Catalysis","of","the","reaction",":","toluene-4-sulfonate","+","NADH","+","O2","=","NAD","+","+","OH-","+","4-sulfobenzyl","alcohol","."),4276211). assertion_content_comment('oboGo_TomatidineUDPGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-glucose","+","a","sterol","=","UDP","+","O-glucosyl-tomatidine","."),4283384). assertion_content_comment('oboGo_Tor2Mei2Ste11complex',s("A","protein","complex","that","contains","the","transcription","factor","Ste11","and","the","RNA","binding","protein","Mei2",";","involved","in","regulation","of","conjugation","in","fission","yeast","."),4361270). assertion_content_comment('oboGo_TpgContainingtelomerebindingcomplex',s("A","complex","composed","of","four","polypeptides",",","a","telomere-protecting","terminal","protein","(","Tpg",")",",","a","telomere-associated","protein","(","Tap",")",",","DNA","polymerase","(","PolA",")","and","topoisomerase","I","(","TopA",")",",","that","functions","in","the","replication","of","the","telomeric","regions","of","linear","chromosomes",",","plasmids","and","circular","replicons","of","some","bacterial","species","."),4327933). assertion_content_comment('oboGo_TraceAminereceptoractivity',s("Combining","with","a","trace","amine","to","initiate","a","change","in","cell","activity",".","Trace","amines","are","biogenic","amines","that","are","synthesized","from","aromatic","amino","acids","and","are","substrates","for","monoamine","oxidase",",","and","are","therefore","detectable","only","at","trace","levels","in","mammals","."),4360483). assertion_content_comment('oboGo_TRAILDeathInducingsignalingcomplex',s("A","protein","complex","formed","upon","binding","of","TRAIL","to","its","ligand",".","The","complex","includes","FADD/Mort1","and","procaspase-8","addition","to","the","ligand-bound","receptor","."),4320099). assertion_content_comment('oboGo_TRAMDependenttollLikereceptor4signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","toll-like","receptor","4","where","the","TRAM","adaptor","mediates","transduction","of","the","signal",".","Toll-like","4","receptors","are","pattern","recognition","receptors","that","bind","bacterial","lipopolysaccharide","(","LPS",")","to","initiate","an","innate","immune","response","."),4380325). assertion_content_comment('oboGo_TRAMDependenttollLikereceptorsignalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","toll-like","receptor","where","the","TRAM","adaptor","mediates","transduction","of","the","signal",".","Toll-like","receptors","directly","bind","pattern","motifs","from","a","variety","of","microbial","sources","to","initiate","innate","immune","response","."),4380163). assertion_content_comment('oboGo_Trans_12_Dihydrobenzene_12_DiolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","NADP","+","+","trans-1",",","2-dihydrobenzene-1",",","2-diol","=","NADPH","+","catechol","."),4365904). assertion_content_comment('oboGo_Trans_12_DihydrodiolphenanthreneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","trans-1",",","2-dihydrodiolphenanthrene","+","NAD","+","=","H","+","+","NADH","+","1",",","2-dihydroxyphenanthrene","."),4278624). assertion_content_comment('oboGo_Trans_2_Decenoyl_Acyl_Carrier_ProteinIsomeraseActivity',s("Catalysis","of","the","reaction",":","trans-dec-2-enoyl-","[","acyl-carrier","protein","]","=","cis-dec-3-enoyl-","[","acyl-carrier","protein","]"),4360709). assertion_content_comment('oboGo_Trans_2_Enoyl_CoAReductaseNADActivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","NAD","+","=","trans-didehydroacyl-CoA","+","NADH","."),4265044). assertion_content_comment('oboGo_Trans_2_Enoyl_CoAReductaseNADPHActivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","NADP","+","=","trans-2",",","3-dehydroacyl-CoA","+","NADPH","+","H","+"),4237699). assertion_content_comment('oboGo_Trans_2_Methyl_5_Isopropylhexa_25_DienalDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","trans-2-methyl-5-isopropylhexa-2",",","5-dienal","+","NAD","+","+","H2O","=","NADH","+","H","+","+","trans-2-methyl-5-isopropylhexa-2",",","5-dienoic","acid","."),4277561). assertion_content_comment('oboGo_Trans_2_Methyl_5_Isopropylhexa_25_Dienoate_CoALigaseActivity',s("Catalysis","of","the","reaction",":","trans-2-methyl-5-isopropylhexa-2",",","5-dienoic","acid","+","ATP","+","CoASH","=","trans-2-methyl-5-isopropylhexa-2",",","5-dienoyl-CoA","+","AMP","+","PPi","."),4348787). assertion_content_comment('oboGo_Trans_34_DihydrodiolphenanthreneSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","trans-3",",","4-dihydrodiolphenanthrene","+","2","X-SO3","(","-",")","=","2","HX","+","phenanthrene-3",",","4-dihydrodiolsulfate","conjugate","."),4275166). assertion_content_comment('oboGo_Trans_4_1_Hydroxynaphth_2_Yl_2_Oxobut_3_EnoateHydratase_AldolaseActivity',s("Catalysis","of","the","reaction",":","trans-4-","(","1","'","-hydroxynaphth-2","'","-yl",")","-2-oxobut-3-enoate","+","H2O","=","pyruvate","+","1-hydroxy-2-naphthaldehyde","."),4273895). assertion_content_comment('oboGo_Trans_4_2_3_Hydroxy_Thionaphthenyl_2_Oxo_3_ButenoateHydrataseActivity',s("Catalysis","of","the","reaction",":","trans-4-","(","2-","(","3-hydroxy",")","-thionaphthenyl",")","-2-oxo-3-butenoate","+","H2O","=","pyruvate","+","3-hydroxy-2-formylbenzothiophene","."),4273940). assertion_content_comment('oboGo_Trans_9R10R_DihydrodiolphenanthreneDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","trans-9R",",","10R-dihydrodiolphenanthrene","+","NAD","+","=","NADH","+","H","+","+","9",",","10-dihydroxyphenanthrene","."),4278553). assertion_content_comment('oboGo_Trans_9R10R_DihydrodiolphenanthreneSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","trans-9R",",","10R-dihydrodiolphenanthrene","+","2","X-SO3","(","-",")","=","2","HX","+","phenanthrene-9",",","10-dihydrodiolsulfate","conjugate","."),4275126). assertion_content_comment('oboGo_Trans_Acenaphthene_12_DiolDehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","+","-",")","-trans-acenaphthene-1",",","2-diol","+","2","NADP","(","+",")","=","acenaphthene-1",",","2-dione","+","2","H","(","+",")","+","2","NADPH","."),4364725). assertion_content_comment('oboGo_TransAcohdahydrolaseactivity',s("Catalysis","of","the","reaction",":","trans-4-amino-6-carboxy-2-oxo-hexa-3",",","5-dienoate","+","H2O","=","fumarylpyruvate","+","NH3","."),4352741). assertion_content_comment('oboGo_TransAconitate2Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","trans-aconitate","=","(","E",")","-3-","(","methoxycarbonyl",")","pent-2-enedioate","+","S-adenosyl-L-homocysteine","."),4308989). assertion_content_comment('oboGo_TransAconitate3Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","+","trans-aconitate","=","(","E",")","-2-","(","methoxycarbonylmethyl",")","but-2-enedioate","+","S-adenosyl-L-homocysteine","."),4359014). assertion_content_comment('oboGo_TransAssemblyOfSLContainingprecatalyticspliceosome',s("Assembly","of","a","spliceosomal","complex","containing","the","SL","RNA","and","the","pre-mRNA","to","be","joined",",","as","well","as","all","the","spliceosomal","snRNPs","involved","in","trans","leader","splicing",".","Formation","of","the","trans","leader","spliceosome","brings","together","the","quadruple","SL/U4/U5/U6","snRNP","and","the","complex","of","the","U2","snRNP","with","the","splice","site","of","the","pre-mRNA","."),3974640). assertion_content_comment('oboGo_TransCarveoldehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","1R",",","5S",")","-carveol","+","NAD","(","+",")","=","(","S",")","-carvone","+","H","(","+",")","+","NADH","."),4341856). assertion_content_comment('oboGo_TransChloroacrylicaciddehalogenaseactivity',s("Catalysis","of","the","reaction",":","trans-3-chloroacrylic","acid","+","H2O","=","H","+","+","malonate","semialdehyde","."),4274415). assertion_content_comment('oboGo_TransCinnamate2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","trans-cinnamate","+","H","(","+",")","+","NADPH","+","O","(","2",")","=","2-coumarate","+","H","(","2",")","O","+","NADP","(","+",")"),4265029). assertion_content_comment('oboGo_TransCinnamate4Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","trans-cinnamate","+","NADPH","+","H","+","+","O2","=","4-hydroxycinnamate","+","NADP","+","+","H2O","."),4301185). assertion_content_comment('oboGo_TranscriptionActivatingfactor30kd',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4220536). assertion_content_comment('oboGo_TranscriptionalActivationByPromoterEnhancerlooping',s("The","formation","and","maintenance","of","DNA","loops","that","juxtapose","the","promoter","and","enhancer","regions","of","RNA","polymerase","II-transcribed","genes","and","activate","transcription","from","an","RNA","polymerase","II","promoter","."),4169912). assertion_content_comment('oboGo_TranscriptionalActivationByPromoterTerminatorlooping',s("The","formation","and","maintenance","of","DNA","loops","that","juxtapose","the","promoter","and","terminator","regions","of","RNA","polymerase","II-transcribed","genes","and","activate","transcription","from","an","RNA","polymerase","II","promoter","."),4155652). assertion_content_comment('oboGo_TranscriptionalOpenComplexFormationAtBacterialTypernapolymerasepromoter',s("Any","process","involved","in","the","melting","of","the","DNA","hybrid","of","the","core","promoter","region","within","the","transcriptional","closed","complex","of","an","RNA","polymerase","II","preinitiation","complex","(","PIC",")","to","produce","an","open","complex","where","the","DNA","duplex","around","the","transcription","initiation","site","is","unwound","to","form","the","transcription","bubble","."),3980591). assertion_content_comment('oboGo_TranscriptionCouplednucleotideExcisionrepairdnadamagerecognition',s("The","identification","of","lesions","on","the","actively","transcribed","strand","of","the","DNA","duplex","as","well","as","a","small","subset","of","lesions","not","recognized","by","the","general","nucleotide-excision","repair","pathway","."),3976853). assertion_content_comment('oboGo_TranscriptionCouplednucleotideExcisionrepair',s("The","nucleotide-excision","repair","process","that","carries","out","preferential","repair","of","DNA","lesions","on","the","actively","transcribed","strand","of","the","DNA","duplex",".","In","addition",",","the","transcription-coupled","nucleotide-excision","repair","pathway","is","required","for","the","recognition","and","repair","of","a","small","subset","of","lesions","that","are","not","recognized","by","the","global","genome","nucleotide","excision","repair","pathway","."),3976838). assertion_content_comment('oboGo_TranscriptionDependenttetheringofrnapolymeraseiigenednaatnuclearperiphery',s("The","chromosome","organization","process","in","which","the","DNA","sequence","containing","a","gene","transcribed","by","RNA","polymerase","II","is","maintained","in","a","specific","location","at","the","nuclear","periphery",".","In","S",".","cerevisiae",",","this","process","involves","cis-acting","DNA","sequences","such","as","the","TATA","box","and","upstream","activating","sequence","(","UAS",")","elements",",","trans-acting","transcriptional","activators",",","and","also","the","3","'","-UTR","of","the","transcript","."),4363274). assertion_content_comment('oboGo_TranscriptionDNADependent',s("The","cellular","synthesis","of","RNA","on","a","template","of","DNA","."),3971038). assertion_content_comment('oboGo_TranscriptionElongationDNADependent',s("The","extension","of","an","RNA","molecule","after","transcription","initiation","and","promoter","clearance","at","a","DNA-dependent","RNA","polymerase","promoter","by","the","addition","of","ribonucleotides","catalyzed","by","an","RNA","polymerase","."),3980555). assertion_content_comment('oboGo_TranscriptionElongationFromBacterialTypernapolymerasepromoter',s("The","extension","of","an","RNA","molecule","after","transcription","initiation","and","promoter","clearance","at","a","bacterial-type","RNA","polymerase","promoter","by","the","addition","of","ribonucleotides","catalyzed","by","a","bacterial-type","RNA","polymerase","."),3980560). assertion_content_comment('oboGo_TranscriptionFactorTFIIIBAlphacomplex',s("A","transcription","factor","TFIIIB-beta","complex","that","contains","the","TATA-binding","protein","(","TBP",")",",","B","'","'","and","a","specialized","homolog","of","the","conserved","subunit","BRF","referred","to","as","BRFU","or","TFIIIB50",",","which","found","in","human","but","not","conserved","in","yeast",";","the","complex","is","involved","in","the","regulation","of","transcription","from","type","3","(","upstream",")","RNA","polymerase","III","promoters","."),4349285). assertion_content_comment('oboGo_TranscriptionFactorTFIIIBBetacomplex',s("A","transcription","factor","TFIIIB-beta","complex","that","contains","the","TATA-binding","protein","(","TBP",")",",","B","'","'","and","BRF",",","and","is","involved","in","the","regulation","of","transcription","from","type","2","RNA","polymerase","III","promoters","."),4349276). assertion_content_comment('oboGo_TranscriptionFromBacterialTypernapolymerasepromoter',s("The","synthesis","of","RNA","from","a","DNA","template","by","RNA","polymerase","II","(","Pol","II",")",",","originating","at","a","Pol","II-specific","promoter","."),3980526). assertion_content_comment('oboGo_TranscriptionInitiationDNADependent',s("Any","process","involved","in","the","assembly","of","the","RNA","polymerase","preinitiation","complex","(","PIC",")","at","the","core","promoter","region","of","a","DNA","template",",","resulting","in","the","subsequent","synthesis","of","RNA","from","that","promoter",".","The","initiation","phase","includes","PIC","assembly","and","the","formation","of","the","first","few","bonds","in","the","RNA","chain",",","including","abortive","initiation",",","which","occurs","when","the","first","few","nucleotides","are","repeatedly","synthesized","and","then","released",".","The","initiation","phase","ends","just","before","and","does","not","include","promoter","clearance",",","or","release",",","which","is","the","transition","between","the","initiation","and","elongation","phases","of","transcription","."),3979118). assertion_content_comment('oboGo_TranscriptionInitiationFromBacterialTypernapolymerasepromoter',s("Any","process","involved","in","the","assembly","of","bacterial-type","RNA","polymerase","preinitiation","complex","(","PIC",")","at","the","core","promoter","region","of","a","DNA","template",",","resulting","in","the","subsequent","synthesis","of","RNA","from","that","promoter",".","The","initiation","phase","includes","PIC","assembly","and","the","formation","of","the","first","few","bonds","in","the","RNA","chain",",","including","abortive","initiation",",","which","occurs","when","the","first","few","nucleotides","are","repeatedly","synthesized","and","then","released",".","The","initiation","phase","ends","just","before","and","does","not","include","promoter","clearance",",","or","release",",","which","is","the","transition","between","the","initiation","and","elongation","phases","of","transcription","."),3980571). assertion_content_comment('oboGo_TranscriptionRegulatoryRegionSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","specific","sequence","of","DNA","that","is","part","of","a","regulatory","region","that","controls","transcription","of","that","section","of","the","DNA",".","The","transcribed","region","might","be","described","as","a","gene",",","cistron",",","or","operon","."),4356335). assertion_content_comment('oboGo_TranscriptionRNA_Dependent_3',s("The","cellular","synthesis","of","RNA","on","a","template","of","RNA","."),4358066). assertion_content_comment('oboGo_TranscriptionRNADependent',s("OBSOLETE",":","The","cellular","synthesis","of","DNA","on","a","template","of","RNA","."),4223879). assertion_content_comment('oboGo_TranscriptionTerminationDNADependent',s("The","cellular","process","that","completes","DNA-dependent","transcription",";","the","formation","of","phosphodiester","bonds","ceases",",","the","RNA-DNA","hybrid","dissociates",",","and","RNA","polymerase","releases","the","DNA","."),3980485). assertion_content_comment('oboGo_TranscriptionTerminationFromBacterialTypernapolymerasepromoter',s("The","process","in","which","the","synthesis","of","an","RNA","molecule","by","a","bacterial-type","RNA","polymerase","using","a","DNA","template","is","completed","."),3980536). assertion_content_comment('oboGo_TranscriptionTerminationSiteSequenceSpecificdnabinding',s("Interacting","selectively","and","non-covalently","with","a","sequence","of","DNA","that","promotes","termination","by","RNA","polymerase",".","The","transcribed","region","might","be","described","as","a","gene",",","cistron",",","or","operon","."),4358312). assertion_content_comment('oboGo_TransepithelialLAscorbicacidtransport',s("The","directed","movement","of","L-ascorbic","acid","from","one","side","of","an","epithelium","to","the","other","."),4178173). assertion_content_comment('oboGo_TransEpoxysuccinatehydrolaseactivity',s("Catalysis","of","the","reaction",":","trans-2",",","3-epoxysuccinate","+","H","(","2",")","O","=","(","2R",",","3S",")","-tartrate","."),4265017). assertion_content_comment('oboGo_TransferaseActivityTransferringAcylGroupsOtherThanAminoAcylgroups',s("Catalysis","of","the","transfer","of","an","acyl","group",",","other","than","amino-acyl",",","from","one","compound","(","donor",")","to","another","(","acceptor",")"),4172660). assertion_content_comment('oboGo_TransferaseActivityTransferringAminoAcylgroups',s("Catalysis","of","the","transfer","of","an","amino-acyl","group","from","one","compound","(","donor",")","to","another","(","acceptor",")"),4187717). assertion_content_comment('oboGo_TransferaseActivityTransferringOneCarbongroups',s("Catalysis","of","the","transfer","of","a","one-carbon","group","from","one","compound","(","donor",")","to","another","(","acceptor",")"),4164114). assertion_content_comment('oboGo_TransferaseActivityTransferringPhosphorusContaininggroups',s("Catalysis","of","the","transfer","of","a","phosphorus-containing","group","from","one","compound","(","donor",")","to","another","(","acceptor",")"),3974932). assertion_content_comment('oboGo_TransferaseActivityTransferringSeleniumContaininggroups',s("Catalysis","of","the","transfer","of","a","selenium-containing","group","from","one","compound","(","donor",")","to","another","(","acceptor",")"),4211678). assertion_content_comment('oboGo_TransferaseActivityTransferringSulfurContaininggroups',s("Catalysis","of","the","transfer","of","a","sulfur-containing","group","from","one","compound","(","donor",")","to","another","(","acceptor",")"),4180928). assertion_content_comment('oboGo_TransFeruloylCoahydrataseactivity',s("Catalysis","of","the","reaction",":","trans-feruloyl-CoA","+","H2O","=","4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA","."),4268862). assertion_content_comment('oboGo_TransFeruloylCoasynthaseactivity',s("Catalysis","of","the","reaction",":","ferulic","acid","+","CoASH","+","ATP","=","trans-feruloyl-CoA","+","products","of","ATP","breakdown","."),4268347). assertion_content_comment('oboGo_TransformingGrowthFactorBeta1production',s("The","appearance","of","transforming","growth","factor-beta1","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4064231). assertion_content_comment('oboGo_TransformingGrowthFactorBeta1Typeiireceptorcomplex',s("A","protein","complex","that","consists","of","a","dimeric","transforming","growth","factor","beta","(","TGF-beta",")","type","II","receptor","bound","to","a","TGF-beta1","dimer","."),4180301). assertion_content_comment('oboGo_TransformingGrowthFactorBeta1TypeiireceptorTypeireceptorcomplex',s("A","protein","complex","that","is","formed","by","the","association","of","a","ligand-bound","TGF-beta","type","II","receptor","dimer","with","a","TGF-beta","type","I","receptor","dimer","."),4180287). assertion_content_comment('oboGo_TransformingGrowthFactorBeta2production',s("The","appearance","of","transforming","growth","factor-beta2","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4064300). assertion_content_comment('oboGo_TransformingGrowthFactorBeta3production',s("The","appearance","of","transforming","growth","factor-beta3","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels","."),4064340). assertion_content_comment('oboGo_TransformingGrowthFactorBetaproduction',s("The","appearance","of","any","member","of","the","transforming","growth","factor-beta","family","of","cytokines","due","to","biosynthesis","or","secretion","following","a","cellular","stimulus",",","resulting","in","an","increase","in","its","intracellular","or","extracellular","levels",".","Transforming","growth","factor-beta","family","members","include","TGF-B1",",","TGF-B2",",","and","TGF-B3","."),4064225). assertion_content_comment('oboGo_TransformingGrowthFactorBetaReceptorCommonPartnercytoplasmicmediatoractivity',s("A","TGF-beta","cytoplasmic","mediator","that","forms","a","complex","with","a","phosphorylated","pathway-specific","mediator",".","The","heterocomplex","translocates","to","the","nucleus","to","regulate","transcription","."),4215397). assertion_content_comment('oboGo_TransformingGrowthFactorBetaReceptorPathwaySpecificcytoplasmicmediatoractivity',s("A","TGF-beta","cytoplasmic","mediator","that","is","phosphorylated","by","a","TGFbeta","receptor","and","complexes","with","a","common-partner","mediator",".","The-","heterocomplex","translocates","to","the","nucleus","to","regulate","transcription","."),4215349). assertion_content_comment('oboGo_TransGeranylCoaisomeraseactivity',s("Catalysis","of","the","reaction",":","trans-geranyl-CoA","=","cis-geranyl-CoA","."),4351019). assertion_content_comment('oboGo_TransGolginetworkmembrane',s("The","lipid","bilayer","surrounding","any","of","the","compartments","that","make","up","the","trans-Golgi","network","."),4067469). assertion_content_comment('oboGo_TransGolginetwork',s("The","network","of","interconnected","tubular","and","cisternal","structures","located","at","the","side","of","the","Golgi","apparatus","distal","to","the","endoplasmic","reticulum",",","from","which","secretory","vesicles","emerge",".","The","trans-Golgi","network","is","important","in","the","later","stages","of","protein","secretion","where","it","is","thought","to","play","a","key","role","in","the","sorting","and","targeting","of","secreted","proteins","to","the","correct","destination","."),4067453). assertion_content_comment('oboGo_TransGolginetworktransportvesiclemembrane',s("The","lipid","bilayer","surrounding","a","vesicle","transporting","substances","between","the","trans-Golgi","network","and","other","parts","of","the","cell","."),4036158). assertion_content_comment('oboGo_TransGolginetworktransportvesicle',s("A","vesicle","that","mediates","transport","between","the","trans-Golgi","network","and","other","parts","of","the","cell","."),4036135). assertion_content_comment('oboGo_TransHexaprenyltranstransferaseactivity',s("Catalysis","of","the","reaction",":","all-trans-hexaprenyl","diphosphate","+","isopentenyl","diphosphate","=","all-trans-heptaprenyl","diphosphate","+","diphosphate","."),4345356). assertion_content_comment('oboGo_Trans_L_3_HydroxyprolineDehydrataseActivity',s("Catalysis","of","the","reaction",":","trans-L-3-hydroxyproline","=","1-pyrroline-2-carboxylate","+","H","(","2",")","O","+","H","(","+",")"),4265006). assertion_content_comment('oboGo_TranslationFactorActivityNonNucleicacidbinding',s("A","translation","regulator","activity","that","does","not","involve","binding","to","nucleic","acids","."),4300206). assertion_content_comment('oboGo_TranslationRepressorActivityNonNucleicacidbinding',s("Antagonizes","the","ribosome-mediated","translation","of","mRNA","into","a","polypeptide","but","does","not","bind","directly","to","nucleic","acid","."),4363639). assertion_content_comment('oboGo_Transmembrane1Electrontransfercarrier',s("Enables","transfer","of","one","electron","across","a","membrane","."),4333265). assertion_content_comment('oboGo_Transmembrane2Electrontransfercarrier',s("Enables","transfer","of","two","electrons","across","a","membrane","."),4333255). assertion_content_comment('oboGo_TransmembraneEphrinreceptoractivity',s("Combining","with","a","transmembrane","ephrin","to","initiate","a","change","in","cell","activity","."),4213854). assertion_content_comment('oboGo_TransmembraneReceptorProteinSerineThreonineKinaseReceptorAssociatedproteinactivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4268795). assertion_content_comment('oboGo_TransmitterGatedchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","solute","by","a","channel","that","opens","when","a","specific","neurotransmitter","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4331004). assertion_content_comment('oboGo_TransmitterGatedionchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","an","ion","by","a","channel","that","opens","when","a","specific","neurotransmitter","has","been","bound","by","the","channel","complex","or","one","of","its","constituent","parts","."),4331008). assertion_content_comment('oboGo_TransOctaprenyltranstransferaseactivity',s("Catalysis","of","the","reaction",":","all-trans-octaprenyl","diphosphate","+","isopentenyl","diphosphate","=","all-trans-nonaprenyl","diphosphate","+","diphosphate","."),4264987). assertion_content_comment('oboGo_TransOHydroxybenzylidenepyruvatehydrataseAldolaseactivity',s("Catalysis","of","the","reaction",":","2-oxo-3-enoate-4-benzenoid","+","H2O","=","pyruvate","+","benzaldehyde","derivative",".","Substrates","are","(","3E",")","-4-","(","5-amino-2-hydroxy-phenyl",")","-2-oxo-but-3-ene-1-oic-acid","(","forms","5-aminosalicylaldehyde",")","and","trans-o-hydroxybenzylidenepyruvate","(","forms","salicylaldehyde",")"),4273981). assertion_content_comment('oboGo_TransPentaprenyltranstransferaseactivity',s("Catalysis","of","the","reaction",":","all-trans-pentaprenyl","diphosphate","+","isopentenyl","diphosphate","=","all-trans-hexaprenyl","diphosphate","+","diphosphate","."),4384591). assertion_content_comment('oboGo_TranspositionDNAMediated',s("Any","process","involved","in","a","type","of","transpositional","recombination","which","occurs","via","a","DNA","intermediate","."),3975112). assertion_content_comment('oboGo_TranspositionRNAMediated',s("Any","process","involved","in","a","type","of","transpositional","recombination","which","occurs","via","an","RNA","intermediate","."),4029843). assertion_content_comment('oboGo_TransTranslation',s("A","translational","elongation","process","in","which","transfer","of","a","translating","ribosome","from","one","mRNA","to","another","RNA","template","takes","place",".","Trans-translation","occurs","during","tmRNA","release","of","stalled","ribosomes","."),4178205). assertion_content_comment('oboGo_TransZeatinbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","trans-zeatin",",","(","2E",")","-2-methyl-4-","(","9H-purin-6-ylamino",")","but-2-en-1-ol","."),4339596). assertion_content_comment('oboGo_TransZeatinmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","trans-zeatin",",","(","2E",")","-2-methyl-4-","(","9H-purin-6-ylamino",")","but-2-en-1-ol","."),4339593). assertion_content_comment('oboGo_TransZeatinoBetaDGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","trans-zeatin","+","UDP-D-glucose","=","O-beta-D-glucosyl-trans-zeatin","+","H","(","+",")","+","UDP","."),4267232). assertion_content_comment('oboGo_Trehalose6Phosphatephosphorylaseactivity',s("Catalysis","of","the","reaction",":","trehalose","6-phosphate","+","phosphate","=","glucose","6-phosphate","+","beta-D-glucose","1-phosphate","."),4269713). assertion_content_comment('oboGo_TrehaloseOMycolyltransferaseactivity',s("Catalysis","of","the","reaction",":","2","alpha",",","alpha","'","-trehalose","6-mycolate","=","alpha",",","alpha","'","-trehalose","6",",","6","'","-bismycolate","+","alpha",",","alpha-trehalose","."),4264976). assertion_content_comment('oboGo_TrehalosePhosphataseactivity',s("Catalysis","of","the","reaction",":","trehalose","6-phosphate","+","H2O","=","trehalose","+","phosphate","."),4199199). assertion_content_comment('oboGo_TriacetateLactonaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","triacetate","lactone","=","triacetate","."),4264961). assertion_content_comment('oboGo_TricaffeoylSpermidine_SAdenosylLMethionineoMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosyl-L-methionine","to","the","oxygen","atom","of","a","tricaffeoyl","spermidine","molecule","."),4182444). assertion_content_comment('oboGo_TrichloroPHydroquinonereductivedehalogenaseactivity',s("Catalysis","of","the","reaction",":","2",",","3",",","6-trichlorohydroquinone","+","2","glutathione","=","2",",","6-dichlorohydroquinone","+","glutathione","disulfide","+","HCl","."),4191515). assertion_content_comment('oboGo_Trichothecene3OAcetyltransferaseactivity',s("Catalysis","of","the","3-O-acetylation","of","a","trichothecene",".","Trichothecenes","are","sesquiterpene","epoxide","mycotoxins","that","act","as","potent","inhibitors","of","eukaryotic","protein","synthesis","."),4299459). assertion_content_comment('oboGo_TriCoumaroylorcaffeoylspermidinemetaHydroxylaseactivity',s("Catalysis","of","the","meta-hydroxylation","of","any","of","the","three","phenolic","rings","on","tricoumaroyl","spermidine","or","any","of","its","mono-","or","dicaffeoyl","spermidine","derivatives","."),4156972). assertion_content_comment('oboGo_TricoumaroylspermidineMetaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","tricoumaroyl","spermidine","+","NADPH","+","O2","=","dicoumaroyl","monocaffeoyl","spermidine","+","NADP","+","+","H2O","."),4157120). assertion_content_comment('oboGo_TRIFDependenttollLikereceptor4signalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","toll-like","4","receptor","where","the","TRIF","adaptor","mediates","transduction","of","the","signal",".","Toll-like","4","receptors","are","pattern","recognition","receptors","that","bind","bacterial","lipopolysaccharide","(","LPS",")","to","initiate","an","innate","immune","response","."),4380151). assertion_content_comment('oboGo_TRIFDependenttollLikereceptorsignalingpathway',s("Any","series","of","molecular","signals","generated","as","a","consequence","of","binding","to","a","toll-like","receptor","where","the","TRIF","adaptor","mediates","transduction","of","the","signal",".","Toll-like","receptors","directly","bind","pattern","motifs","from","a","variety","of","microbial","sources","to","initiate","innate","immune","response","."),4380138). assertion_content_comment('oboGo_TriFeruloylorhydroxyferuloylspermidinemetaHydroxylaseactivity',s("Catalysis","of","the","meta-hydroxylation","of","any","of","the","three","phenolic","rings","on","triferuloyl","spermidine","or","any","of","its","mono-","or","di-","(","hydroxyferuloyl",")","-spermidine","derivatives","."),4156943). assertion_content_comment('oboGo_TriferuloylspermidineMetaHydroxylaseactivity',s("Catalysis","of","the","reaction",":","triferuloyl","spermidine","+","NADPH","+","O2","=","diferuloyl","mono-","(","hydroxyferuloyl",")","spermidine","+","NADP","+","+","H2O","."),4156954). assertion_content_comment('oboGo_TriglycerideRichlipoproteinparticleclearance',s("The","process","in","which","a","triglyceride-rich","lipoprotein","particle","is","removed","from","the","blood","via","receptor-mediated","endocytosis","and","its","constituent","parts","degraded","."),4125650). assertion_content_comment('oboGo_TriglycerideRichlipoproteinparticleremodeling',s("The","acquisition",",","loss","or","modification","of","a","protein","or","lipid","within","a","triglyceride-rich","lipoprotein","particle",",","including","the","hydrolysis","of","triglyceride","by","lipoprotein","lipase",",","with","the","subsequent","loss","of","free","fatty","acid",",","and","the","transfer","of","cholesterol","esters","to","a","triglyceride-rich","lipoprotein","particle","by","cholesteryl","ester","transfer","protein","(","CETP",")",",","with","the","simultaneous","transfer","of","triglyceride","from","a","triglyceride-rich","lipoprotein","particle","."),4038041). assertion_content_comment('oboGo_TriglycerideRichlipoproteinparticle',s("A","plasma","lipoprotein","particle","that","has","a","hydrophobic","core","enriched","in","triglycerides","surrounded","by","an","amphipathic","monolayer","of","phospholipids",",","cholesterol","and","apolipoproteins",".","Triglyceride-rich","lipoproteinparticles","transport","lipids",",","which","are","non-covalently","associated","with","the","particles",",","in","the","blood","."),4355792). assertion_content_comment('oboGo_TriglycerideSteroloAcyltransferaseactivity',s("Catalysis","of","the","reaction",":","a","3-beta-hydroxysterol","+","triacylglycerol","=","a","3-beta-hydroxysterol","ester","+","1",",","2-diacylglycerol","."),4366109). assertion_content_comment('oboGo_TrihydroxyferuloylSpermidineOMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","trihydroxyferuloyl","spermidine","+","S-adenosyl-L-methionine","=","dihydroxyferuloyl-sinapoyl","spermidine","+","S-adenosyl-L-homocysteine","+","H","+"),4182082). assertion_content_comment('oboGo_TrihydroxyferuloylSpermidine_SAdenosylLMethionineoMethyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","methyl","group","from","S-adenosyl-L-methionine","to","the","oxygen","atom","of","a","trihydroxyferuloyl","spermidine","molecule","."),4182453). assertion_content_comment('oboGo_TrimethylamineNOxidereductaseactivity',s("Catalysis","of","the","reaction",":","NADH","+","H","+","+","trimethylamine-N-oxide","=","NAD","+","+","trimethylamine","+","H2O","."),4256845). assertion_content_comment('oboGo_TrimethylamineNOxidereductasecomplex',s("An","enzyme","complex","that","catalyzes","the","reduction","of","trimethylamine","N-oxide","to","trimethylamine","."),4259804). assertion_content_comment('oboGo_TrimethylamineNOxidereductasecytochromecactivity',s("Catalysis","of","the","reaction",":","trimethylamine","+","2","(","ferricytochrome","c",")","-subunit","+","H2O","=","trimethylamine-N-oxide","+","2","(","ferrocytochrome","c",")","-subunit","+","2","H","+"),4277885). assertion_content_comment('oboGo_TrimethylamineOxidealdolaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","trimethylamine","N-oxide","=","dimethylamine","+","formaldehyde","."),4265054). assertion_content_comment('oboGo_TrimethylsulfoniumTetrahydrofolatenMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","(","6S",")","-5",",","6",",","7",",","8-tetrahydrofolate","+","trimethylsulfonium","=","(","6S",")","-5-methyl-5",",","6",",","7",",","8-tetrahydrofolate","+","dimethyl","sulfide","+","H","(","+",")"),4365460). assertion_content_comment('oboGo_TriNButyltindioxygenaseactivity',s("Catalysis","of","the","reaction",":","tri-n-butyltin","+","O2","+","2","H","+","+","2","e-","=","H2O","+","beta-hydroxybutyldibutyltin","."),4275444). assertion_content_comment('oboGo_TriNButyltinmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","tri-n-butyltin",",","an","organometallic","compound","composed","of","three","butyl","chains","attached","to","a","tin","atom",".","Tri-n-butyltin","is","used","as","an","antifouling","agent","in","ship","bottom","paints","and","can","be","toxic","to","many","marine","organisms","."),4272703). assertion_content_comment('oboGo_TriosePhosphateisomeraseactivity',s("Catalysis","of","the","reaction",":","D-glyceraldehyde","3-phosphate","=","glycerone","phosphate","."),4199277). assertion_content_comment('oboGo_TriosePhosphate_Phosphateantiporteractivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","triose-phosphate","(","out",")","+","phosphate","(","in",")","=","triose-phosphate","(","in",")","+","phosphate","(","out",")"),4260950). assertion_content_comment('oboGo_TriosePhosphatetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","triose","phosphate","from","one","side","of","a","membrane","to","the","other","."),4168365). assertion_content_comment('oboGo_TripartiteATPIndependentperiplasmictransportercomplex',s("A","complex","consisting","of","two","membrane","proteins","and","one","extracytoplasmic","solute","receptor",".","Such","transporters","transport","a","variety","of","substrates","without","direct","ATP","power",",","instead","using","energy","from","ion","gradients","."),4319632). assertion_content_comment('oboGo_TripeptidylPeptidaseactivity',s("Catalysis","of","the","release","of","an","N-terminal","tripeptide","from","a","polypeptide","."),4209799). assertion_content_comment('oboGo_TripeptidylPeptidaseiactivity',s("OBSOLETE",".","Catalysis","of","the","release","of","an","N-terminal","tripeptide","from","a","polypeptide",";","requires","acid","pH","."),4237341). assertion_content_comment('oboGo_TripeptidylPeptidaseiiactivity',s("OBSOLETE",".","Catalysis","of","the","release","of","an","N-terminal","tripeptide","from","a","polypeptide","at","neutral","pH","."),4209802). assertion_content_comment('oboGo_TriphosphoribosylDephosphoCoasynthaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","3-dephospho-CoA","=","2","'","-","(","5","'","'","-triphosphoribosyl",")","-3","'","-dephospho-CoA","+","adenine","."),4362227). assertion_content_comment('oboGo_TripletCodonAminoacidadaptoractivity',s("The","codon","binding","activity","of","a","tRNA","that","positions","an","activated","amino","acid",",","mediating","its","insertion","at","the","correct","point","in","the","sequence","of","a","nascent","polypeptide","chain","during","protein","synthesis","."),4218346). assertion_content_comment('oboGo_TRNA_2_Methylthio_N_6_Cis_HydroxyIsopentenylAdenosine_HydroxylaseActivity',s("Catalysis","of","the","reaction",":","tRNA-","(","2-methylthio-N-6-isopentenyl","adenosine",")","=","tRNA-","(","2-methylthio-N-6-","(","cis-hydroxy",")","isopentenyl","adenosine",")","+","O2",".","2-methylthio-N-6-isopentenyl","adenosine","is","also","known","as","ms2i6A",";","2-methylthio-N-6-","(","cis-hydroxy",")","isopentenyl","adenosine","is","also","known","as","ms2io6A","and","2-methylthio-cis-ribozeatin","."),4298409). assertion_content_comment('oboGo_TRNA2ORibosemethylationguideactivity',s("Specifies","the","site","of","2","'","-O-ribose","methylation","in","a","tRNA","molecule","by","base","pairing","with","a","short","sequence","around","the","target","residue","."),4310612). assertion_content_comment('oboGo_TRNA2Phosphotransferaseactivity',s("Catalysis","of","the","reaction",":","2","'","-phospho-","[","ligated","tRNA","]","+","NAD","+","=","mature","tRNA","+","ADP","ribose","1","'","'",",","2","'","'","-phosphate","+","nicotinamide","+","H2O",".","This","reaction","is","the","transfer","of","the","splice","junction","2-phosphate","from","ligated","tRNA","to","NAD","+","to","produce","ADP-ribose","1","'","-2","'","cyclic","phosphate","."),4346491). assertion_content_comment('oboGo_TRNA2Selenouridinesynthaseactivity',s("Catalysis","of","the","reaction",":","5-methylaminomethyl-2-thiouridine","+","selenophosphate","=","5-methylaminomethyl-2-selenouridine","+","phosphate","(","at","the","wobble","position","in","tRNA",")"),4327216). assertion_content_comment('oboGo_TRNA3Endprocessing',s("The","process","in","which","the","3","'","end","of","a","pre-tRNA","molecule","is","converted","to","that","of","a","mature","tRNA","."),4157945). assertion_content_comment('oboGo_TRNA3Terminalccaaddition',s("Post-transcriptional","addition","of","the","terminal","3","'","CCA","sequence","to","a","tRNA","which","does","not","encode","this","sequence","within","the","primary","transcript","."),4383741). assertion_content_comment('oboGo_TRNA3Trailercleavageendonucleolytic',s("Endonucleolytic","cleavage","of","the","3","'","-end","of","the","pre-tRNA","as","part","of","the","process","of","generating","the","mature","3","'","-end","of","the","tRNA","."),4157953). assertion_content_comment('oboGo_TRNA3Trailercleavageexonucleolytic',s("Exonucleolytic","cleavage","of","the","3","'","-end","of","the","pre-tRNA","as","part","of","the","process","of","generating","the","mature","3","'","-end","of","the","tRNA","."),4357418). assertion_content_comment('oboGo_TRNA3Trailercleavage',s("Cleavage","of","the","3","'","-end","of","the","pre-tRNA","as","part","of","the","process","of","generating","the","mature","3","'","-end","of","the","tRNA",";","may","involve","endonucleolytic","or","exonucleolytic","cleavage",",","or","both","."),4157949). assertion_content_comment('oboGo_TRNA5Leaderremoval',s("Generation","of","the","mature","5","'","-end","of","the","tRNA",",","usually","via","an","endonucleolytic","cleavage","by","RNase","P","."),4383719). assertion_content_comment('oboGo_TRNA5_Methylaminomethyl_2_Thiouridylate_MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","5-methylaminomethyl-2-thiouridylate","."),4199264). assertion_content_comment('oboGo_TRNAA64_2_O_RibosylphosphateTransferaseActivity',s("Catalysis","of","the","transfer","of","a","phosphoribosyl","group","from","5","'","-phosphoribosyl-1","'","-pyrophosphate","to","position","64","of","initiator","tRNA","."),4318211). assertion_content_comment('oboGo_TRNAAdenine_5758_N1_MethyltransferaseActivity',s("Catalysis","of","the","methylation","of","adenine-57","and","adenine-58","in","the","T-loop","of","tRNA","."),4327166). assertion_content_comment('oboGo_TRNAAdenineN1Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","N1-methyladenine","."),4304761). assertion_content_comment('oboGo_TRNAAdenineN6Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","N6-methyladenine","."),4304689). assertion_content_comment('oboGo_TRNAContainingribonucleoproteincomplexexportfromnucleus',s("The","directed","movement","of","a","ribonucleoprotein","complex","that","contains","transfer","RNA","from","the","nucleus","to","the","cytoplasm","."),4164032). assertion_content_comment('oboGo_TRNACytosine_2_O__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","2","'","-O-methylcytosine","."),4192118). assertion_content_comment('oboGo_TRNACytosine_5__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","5-methylcytosine","."),4304748). assertion_content_comment('oboGo_TRNAExonLigationUtilizing23CyclicPhosphateOf5Exonassourceoflinkagephosphate',s("A","tRNA","exon","ligation","process","in","which","the","splice","junction","phosphate","is","derived","from","the","2","'",",","3","'","cyclic","phosphate","at","the","3","'","-end","of","the","5","'","-exon",".","This","type","of","ligation","to","rejoin","the","5","'","and","3","'","exons","of","a","tRNA","is","observed","in","wheat",",","Chlamydomonas",",","and","vertebrate","species","including","humans","."),4363265). assertion_content_comment('oboGo_TRNAGuanineN1Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","N1-methylguanine","."),4256655). assertion_content_comment('oboGo_TRNAGuanineN2Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","N2-methylguanine","."),4199240). assertion_content_comment('oboGo_TRNAGuanineN7Methyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","N7-methylguanine","."),4245923). assertion_content_comment('oboGo_TRNAGuanosine_2_O__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","2","'","-O-methylguanosine","."),4256806). assertion_content_comment('oboGo_TRNAIleLysidinesynthaseactivity',s("Catalysis","of","the","ligation","of","lysine","onto","the","cytidine","residue","present","at","the","wobble","position","(","usually","position","34",")","of","an","AUA-specific","isoleucine","tRNA",",","to","form","the","derivative","lysidine",".","This","modification","converts","both","the","codon","specificity","of","tRNA","(","Ile",")","from","AUG","to","AUA","and","its","amino","acid","specificity","from","methionine","to","isoleucine","."),4329831). assertion_content_comment('oboGo_TRNAIntronendonucleaseactivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","pre-tRNA",",","producing","5","'","-hydroxyl","and","2","'",",","3","'","-cyclic","phosphate","termini",",","and","specifically","removing","the","intron","."),4346474). assertion_content_comment('oboGo_TRNAIntronendonucleasecomplex',s("A","protein","complex","that","catalyzes","the","endonucleolytic","cleavage","of","pre-tRNA",",","producing","5","'","-hydroxyl","and","2","'",",","3","'","-cyclic","phosphate","termini",",","and","specifically","removing","the","intron","."),4346506). assertion_content_comment('oboGo_TRNANAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","cytidine","=","CoA","+","N4-acetylcytidine",".","The","cytidine","is","within","the","polynucleotide","chain","of","a","tRNA","."),4286251). assertion_content_comment('oboGo_TRNAQueuosinebetaMannosyltransferaseactivity',s("Catalysis","of","the","reaction",":","GDP-mannose","+","tRNA","(","Asp",")","-queuosine","=","GDP","+","tRNA","(","Asp",")","-O-5","'","'","-beta-D-mannosylqueuosine","."),4304738). assertion_content_comment('oboGo_TRNAReExportfromnucleus',s("The","directed","movement","from","the","nucleus","to","the","cytoplasm","of","a","tRNA","that","was","previously","exported","to","the","cytoplasm","and","then","imported","back","into","the","nucleus",".","The","processes","of","primary","tRNA","export","and","secondary","export","(","re-export",")","can","be","distinguished","because","in","organisms","in","which","tRNA","splicing","occurs","in","the","cytoplasm",",","the","export","of","a","mature","tRNA","must","occur","by","re-export","."),4172207). assertion_content_comment('oboGo_TRNASelenoModification',s("The","substitution","of","a","selenium","atom","for","a","sulfur","atom","in","a","ribonucleotide","in","a","tRNA","molecule","."),4173138). assertion_content_comment('oboGo_TRNA_SpecificAdenosine_37DeaminaseActivity',s("Catalysis","of","the","reaction",":","adenosine-37","+","H2O","=","inosine-37","+","NH3",",","in","a","tRNA-Ala","molecule","."),4327229). assertion_content_comment('oboGo_TRNASpecificadenosinedeaminaseactivity',s("Catalysis","of","the","reaction",":","adenosine","+","H2O","=","inosine","+","NH3",",","in","a","tRNA","molecule","."),4255995). assertion_content_comment('oboGo_TRNASpecificribonucleaseactivity',s("Catalysis","of","the","hydrolysis","of","phosphodiester","bonds","in","tRNA","molecules","."),4204774). assertion_content_comment('oboGo_TRNASplicingligasecomplex',s("A","protein","complex","that","catalyzes","the","ligation","of","cleaved","pre-tRNAs","by","directly","joining","spliced","tRNA","halves","to","mature-sized","tRNAs","by","incorporating","the","precursor-derived","splice","junction","phosphate","into","the","mature","tRNA","as","a","canonical","3","'",",","5","'","-phosphodiester","."),4157971). assertion_content_comment('oboGo_TRNAThioModification',s("The","addition","a","sulfur","atom","to","a","nucleotide","in","a","tRNA","molecule","."),4178192). assertion_content_comment('oboGo_TRNATypeintronsplicesiterecognitionandcleavage',s("RNA","processing","that","begins","when","the","tertiary","structure","of","a","tRNA","type","intron","is","recognized",",","and","ends","when","the","endonucleolytic","cleavage","of","the","RNA","at","both","the","5","'","and","3","'","splice","sites","occurs","."),3974849). assertion_content_comment('oboGo_TRNAUracil_2_O__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","2","'","-O-methyluracil","."),4192059). assertion_content_comment('oboGo_TRNAUracil_5__MethyltransferaseActivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","=","S-adenosyl-L-homocysteine","+","tRNA","containing","thymine","."),4256825). assertion_content_comment('oboGo_TRNAUridineaminocarboxypropyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tRNA","uridine","=","5","'","-methylthioadenosine","+","tRNA","3-","(","3-amino-3-carboxypropyl",")","-uridine","."),4304700). assertion_content_comment('oboGo_TRNAYsplicing',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4224108). assertion_content_comment('oboGo_TrypanothioneDisulfidereductaseactivity',s("Catalysis","of","the","reaction",":","NADP","+","+","trypanothione","=","NADPH","+","H","+","+","trypanothione","disulfide","."),4296882). assertion_content_comment('oboGo_Tryptophan23Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","L-tryptophan","+","O2","=","N-formyl-L-kynurenine","."),4199678). assertion_content_comment('oboGo_Tryptophan2CMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","(","1","+",")","+","L-tryptophan","=","S-adenosyl-L-homocysteine","+","L-2-methyltryptophan","+","H","(","+",")"),4308495). assertion_content_comment('oboGo_Tryptophan2Dioxygenaseactivity',s("Catalysis","of","the","reaction",":","L-tryptophan","+","O2","=","3-indoleglycolaldehyde","+","CO2","+","NH3","."),4264590). assertion_content_comment('oboGo_Tryptophan2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","L-tryptophan","+","O","(","2",")","=","CO","(","2",")","+","H","(","2",")","O","+","indole-3-acetamide","."),4264611). assertion_content_comment('oboGo_Tryptophan5Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","L-tryptophan","+","tetrahydrobiopterin","+","O2","=","5-hydroxy-L-tryptophan","+","4-alpha-hydroxytetrahydrobiopterin","+","H2O","."),4205144). assertion_content_comment('oboGo_TryptophanAlphaBetaOxidaseactivity',s("Catalysis","of","the","reaction",":","L-tryptophan","+","O","(","2",")","=","alpha",",","beta-didehydrotryptophan","+","H","(","2",")","O","(","2",")","+","H","(","+",")"),4277931). assertion_content_comment('oboGo_TryptophanCatabolicProcessToAcetylCoa',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","tryptophan","into","other","compounds",",","including","acetyl-CoA","."),4241861). assertion_content_comment('oboGo_TryptophanCatabolicProcessToIndole_3_Acetate',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","tryptophan","into","other","compounds",",","including","indole-3-acetate","."),4241845). assertion_content_comment('oboGo_TryptophanIndependentindoleaceticacidbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","indoleacetic","acid",",","independent","of","tryptophan","."),4262535). assertion_content_comment('oboGo_TryptophanPhenylpyruvatetransaminaseactivity',s("Catalysis","of","the","reaction",":","keto-phenylpyruvate","+","L-tryptophan","=","3-","(","indol-3-yl",")","pyruvate","+","L-phenylalanine","."),4367580). assertion_content_comment('oboGo_TryptophanTrnaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","L-tryptophan","+","tRNA","(","Trp",")","=","AMP","+","diphosphate","+","L-tryptophanyl-tRNA","(","Trp",")"),4199738). assertion_content_comment('oboGo_TryptophanylTrnaaminoacylation',s("The","process","of","coupling","tryptophan","to","tryptophanyl-tRNA",",","catalyzed","by","tryptophanyl-tRNA","synthetase",".","In","tRNA","aminoacylation",",","the","amino","acid","is","first","activated","by","linkage","to","AMP","and","then","transferred","to","either","the","2","'","-","or","the","3","'","-hydroxyl","group","of","the","3","'","-adenosine","residue","of","the","tRNA","."),4179201). assertion_content_comment('oboGo_TSC1Tsc2complex',s("A","heterodimeric","protein","complex","consisting","of","tumerin","and","hamartin",";","its","formation","may","regulate","hamartin","homomultimer","formation",".","The","complex","acts","as","a","GTPase","activating","protein","(","GAP",")","for","the","small","GTPase","(","Rheb",")",",","and","inhibits","the","TOR","signaling","pathway","."),4340546). assertion_content_comment('oboGo_TTubuleorganization',s("A","process","that","is","carried","out","at","the","cellular","level","that","results","in","the","assembly",",","arrangement","of","constituent","parts",",","or","disassembly","of","the","T-tubule",".","A","T-tubule","is","an","invagination","of","the","plasma","membrane","of","a","muscle","cell","that","extends","inward","from","the","cell","surface","around","each","myofibril","."),4066395). assertion_content_comment('oboGo_TTubule',s("Invagination","of","the","plasma","membrane","of","a","muscle","cell","that","extends","inward","from","the","cell","surface","around","each","myofibril",".","The","ends","of","T-tubules","make","contact","with","the","sarcoplasmic","reticulum","membrane","."),4048148). assertion_content_comment('oboGo_TubulinDependentatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",".","This","reaction","requires","the","presence","of","a","tubulin","dimer","to","accelerate","release","of","ADP","and","phosphate","."),4176010). assertion_content_comment('oboGo_TubulinGlutamicacidligaseactivity',s("Catalysis","of","the","posttranslational","transfer","of","one","or","more","glutamate","residues","to","the","gamma-carboxyl","group","(","s",")","of","one","or","more","specific","glutamate","residues","on","a","tubulin","molecule","."),4176153). assertion_content_comment('oboGo_TubulinGlycineligaseactivity',s("Catalysis","of","the","posttranslational","transfer","of","one","or","more","glycine","residues","to","a","specific","glutamate","residue","on","a","target","tubulin","molecule",";","acts","on","alpha","or","beta","tubulin","."),4176203). assertion_content_comment('oboGo_TubulinNAcetyltransferaseactivity',s("Catalysis","of","the","reaction",":","acetyl-CoA","+","(","alpha-tubulin",")","L-lysine","=","CoA","+","(","alpha-tubulin",")","N6-acetyl-L-lysine","."),4234186). assertion_content_comment('oboGo_TubulinSpecificchaperoneactivity',s("OBSOLETE",".","Assists","in","the","correct",",","non-covalent","assembly","of","tubulin-containing","structures","in","vivo",",","but","is","not","a","component","of","the","assembled","structures","when","performing","its","normal","biological","function","."),4269279). assertion_content_comment('oboGo_TubulinTyrosineligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","detyrosinated","alpha-tubulin","+","L-tyrosine","=","alpha-tubulin","+","ADP","+","phosphate","."),4199648). assertion_content_comment('oboGo_TubulinylTyrcarboxypeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","cleavage","of","the","Glu-Tyr","bond","to","release","the","C-terminal","tyrosine","residue","from","the","native","tyrosinated","tubulin",".","Inactive","on","Z-Glu-Tyr","."),4210532). assertion_content_comment('oboGo_TumorNecrosisFactorMediatedsignalingpathway',s("A","series","of","molecular","signals","generated","as","a","consequence","of","tumor","necrosis","factor","binding","to","a","cell","surface","receptor","."),4025818). assertion_content_comment('oboGo_TungstenIncorporationIntoMetalloSulfurcluster',s("The","incorporation","of","tungsten","into","a","metallo-sulfur","cluster","."),4287478). assertion_content_comment('oboGo_TungstenIncorporationIntoTungstenMolybdopterincomplex',s("The","incorporation","of","tungsten","into","a","tungsten-molybdopterin","complex","."),4287454). assertion_content_comment('oboGo_TungstenIncorporationViaLSelenocysteinyltungstenbismolybdopteringuaninedinucleotide',s("The","incorporation","of","tungsten","into","a","protein","via","L-selenocysteinyl","tungsten","bis","(","molybdopterin","guanine","dinucleotide",")"),4287457). assertion_content_comment('oboGo_TUtpcomplex',s("A","protein","complex","that","forms","a","subcomplex","of","the","90S","preribosome","and","is","required","for","the","subsequent","assembly","of","the","rest","of","the","preribosome",".","In","S",".","cerevisiae",",","it","is","composed","of","Utp5p",",","Utp4p",",","Nan1p",",","Utp8p",",","Utp9p",",","Utp10","and","Utp15p","."),4075007). assertion_content_comment('oboGo_TwoComponentresponseregulatoractivity',s("Responds","to","a","two-component","sensor","to","initiate","a","change","in","cell","state","or","activity",".","The","activity","of","the","response","regulator","is","regulated","by","transfer","of","a","phosphate","from","a","histidine","residue","in","the","sensor",",","to","an","aspartate","residue","in","the","response","regulator",".","Many","but","not","all","response","regulators","act","as","transcriptional","regulators","to","elicit","a","response","."),4346160). assertion_content_comment('oboGo_TwoComponentsensoractivity',s("Catalysis","of","the","phosphorylation","of","a","histidine","residue","in","response","to","detection","of","an","extracellular","signal","such","as","a","chemical","ligand","or","change","in","environment",",","to","initiate","a","change","in","cell","state","or","activity",".","The","two-component","sensor","is","a","histidine","kinase","that","autophosphorylates","a","histidine","residue","in","its","active","site",".","The","phosphate","is","then","transferred","to","an","aspartate","residue","in","a","downstream","response","regulator",",","to","trigger","a","response","."),4346171). assertion_content_comment('oboGo_TwoComponentsignaltransductionsystemphosphorelay',s("A","conserved","series","of","molecular","signals","found","in","prokaryotes","and","eukaryotes",";","involves","autophosphorylation","of","a","histidine","kinase","and","the","transfer","of","the","phosphate","group","to","an","aspartate","that","then","acts","as","a","phospho-donor","to","response","regulator","proteins","."),4021901). assertion_content_comment('oboGo_Type1MelaninConcentratinghormonereceptorbinding',s("Interacting","selectively","and","non-covalently","with","a","type","1","melanin-concentrating","hormone","receptor","."),4322992). assertion_content_comment('oboGo_Type2MelaninConcentratinghormonereceptorbinding',s("Interacting","selectively","and","non-covalently","with","a","type","2","melanin-concentrating","hormone","receptor","."),4322982). assertion_content_comment('oboGo_TypeIIIProteinVirulenceRelatedsecretoractivity',"OBSOLETE.",4292177). assertion_content_comment('oboGo_TypeIIISiteSpecificdeoxyribonucleaseactivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","DNA","to","give","double-stranded","fragments","with","terminal","5","'","-phosphates",".","ATP","hydrolysis","is","required",".","Cleavage","is","dependent","on","the","presence","of","two","copies","of","a","specific","recognition","sequence","in","an","inverse","orientation","in","the","DNA",".","Cleavage","occurs","at","a","specific","distance","from","one","of","the","recognition","sites","."),4290304). assertion_content_comment('oboGo_TypeIIISiteSpecificdeoxyribonucleasecomplex',s("A","heterodimeric","enzyme","complex","composed","of","two","subunits",",","Res","and","Mod",",","that","functions","as","an","endonuclease","and","cleaves","DNA",".","Cleavage","will","only","occur","when","there","are","two","un-methylated","copies","of","a","specific","recognition","site","in","an","inverse","orientation","on","the","DNA",".","Cleavage","occurs","at","a","specific","distance","away","from","one","of","the","recognition","sites",".","The","Mod","subunit","can","act","alone","as","a","methyltansferase",".","DNA","restriction","systems","such","as","this","are","used","by","bacteria","to","defend","against","phage","and","other","foreign","DNA","that","may","enter","a","cell","."),4233367). assertion_content_comment('oboGo_TypeIInterferonMediatedsignalingpathway',s("A","series","of","molecular","events","generated","as","a","consequence","of","a","type","I","interferon","binding","to","a","cell","surface","receptor",".","Type","I","interferons","include","the","interferon-alpha",",","beta",",","delta",",","episilon",",","zeta",",","kappa",",","tau",",","and","omega","gene","families","."),4114541). assertion_content_comment('oboGo_TypeIISiteSpecificdeoxyribonucleaseactivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","DNA","to","give","specific","double-stranded","fragments","with","terminal","5","'","-phosphates","and","3","'","hydroxyls",".","Cleavage","is","dependent","on","the","presence","in","the","DNA","of","a","specific","recognition","site",";","cleavage","occurs","at","or","very","near","this","recognition","site","."),4256889). assertion_content_comment('oboGo_TypeIISiteSpecificdeoxyribonucleasecomplex',s("A","protein","complex","that","functions","as","an","endonuclease","to","cleave","DNA","at","or","near","a","specific","recognition","site",",","when","that","site","is","unmethylated",".","These","complexes","may","be","dimers","or","tetramers",";","it","is","also","possible","for","the","endonuclease","to","be","in","a","complex","with","the","corresponding","methyltransferase","that","methylates","the","recognition","site",".","DNA","restriction","systems","such","as","this","are","used","by","bacteria","to","defend","against","phage","and","other","foreign","DNA","that","may","enter","a","cell","."),4260226). assertion_content_comment('oboGo_TypeISiteSpecificdeoxyribonucleaseactivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","DNA","to","give","random","double-stranded","fragments","with","terminal","5","'","or","3","'","protrusions",";","ATP","is","simultaneously","hydrolyzed",".","Cleavage","is","dependent","on","the","presence","in","the","DNA","of","a","specific","recognition","site",".","Cleavage","may","occur","hundreds","or","thousands","of","base","pairs","away","from","the","recognition","site","due","to","translocation","of","DNA","."),4256872). assertion_content_comment('oboGo_TypeISiteSpecificdeoxyribonucleasecomplex',s("A","multisubunit","complex","composed","of","two","copies","of","a","restriction","(","R",")","subunit",",","two","copies","of","a","methylation","(","M",")","subunit",",","and","one","copy","of","a","specificity","(","S",")","subunit",".","This","complex","recognizes","specific","short","DNA","sequences","(","through","the","S","subunit",")",",","and","binds","to","them",".","If","the","recognition","site","is","hemimethylated",",","the","complex","acts","as","a","methyltransferase","which","modifies","the","recognition","site",",","using","S-adenosylmethionine","as","the","methyl","donor",".","Only","the","M","and","S","subunits","are","required","for","this","reaction",".","If","the","complex","binds","to","an","unmethylated","recognition","site",",","then","the","complex","translocates","the","DNA","bidirectionally","in","an","ATP-dependent","manner",".","When","the","translocation","is","stalled","by","impact","with","another","complex","or","unusual","DNA","structure",",","the","enzyme","functions","as","an","endonuclease","and","cleavage","of","the","DNA","will","occur",",","hundreds","or","thousands","of","base","pairs","away","from","the","recognition","site",".","These","DNA","restriction","systems","are","used","by","bacteria","to","defend","against","phage","and","other","foreign","DNA","that","may","enter","a","cell","."),4233379). assertion_content_comment('oboGo_TypeIVPiliDependentaggregation',s("The","formation","of","bacterial","aggregates","in","liquid","culture","dependent","on","the","presence","of","Type","IV","pili","."),4194737). assertion_content_comment('oboGo_TypeIVPiliDependentlocalizedadherencetohost',s("Attachment","of","bacterial","clusters","to","the","surface","of","the","host","in","a","type","IV","pili","dependent","manner",".","The","host","is","defined","as","the","larger","of","the","organisms","involved","in","a","symbiotic","interaction","."),4194727). assertion_content_comment('oboGo_TypeIVPilusDependentmotility',s("Any","process","involved","in","the","controlled","movement","of","a","bacterial","cell","which","is","dependent","on","the","presence","of","type","IV","pili",".","Includes","social","gliding","motility","and","twitching","motility","."),4317725). assertion_content_comment('oboGo_TypeIVProteinDNAProteinsecretoractivity',"OBSOLETE.",4292167). assertion_content_comment('oboGo_TypeIVSiteSpecificdeoxyribonucleaseactivity',s("Catalysis","of","the","endonucleolytic","cleavage","of","DNA","in","a","site","specific","manner",".","Cleavage","is","dependent","on","the","presence","of","a","specific","recognition","site","in","the","DNA","which","must","be","modified","(","e.g",".","methylated",",","hydroxymethylated",",","glucosyl-hydroxymethylated",")"),4330443). assertion_content_comment('oboGo_TypeIVSiteSpecificdeoxyribonucleasecomplex',s("A","complex","consisting","of","two","proteins","which","acts","as","an","endonuclease","in","DNA","sequences","containing","a","specific","modified","recognition","site",".","Modifications","may","include","methylation",",","hydroxymethylation",",","and","glucosyl-hydroxymethylation","."),4330492). assertion_content_comment('oboGo_TyramineBetahydroxylaseactivity',s("Catalysis","of","the","hydroxylation","of","tyramine","to","form","octopamine","."),4199591). assertion_content_comment('oboGo_TyramineNFeruloyltransferaseactivity',s("Catalysis","of","the","reaction",":","feruloyl-CoA","+","tyramine","=","CoA","+","N-feruloyltyramine","."),4264702). assertion_content_comment('oboGo_TyramineNMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","tyramine","=","N-methyltyramine","+","S-adenosyl-L-homocysteine","+","H","(","+",")"),4308849). assertion_content_comment('oboGo_Tyrosine23Aminomutaseactivity',s("Catalysis","of","the","reaction",":","L-tyrosine","=","3-amino-3-","(","4-hydroxyphenyl",")","propanoate","."),4264677). assertion_content_comment('oboGo_Tyrosine3Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","L-tyrosine","+","tetrahydrobiopterin","+","O2","=","3",",","4-dihydroxy-L-phenylalanine","+","4-alpha-hydroxytetrahydrobiopterin","+","H2O","."),4205131). assertion_content_comment('oboGo_Tyrosine3Monooxygenasekinaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","[","tyrosine-3-monooxygenase","]","=","ADP","+","phospho-","[","tyrosine-3-monooxygenase","]"),4264728). assertion_content_comment('oboGo_TyrosineArginineligaseactivity',s("Catalysis","of","the","reaction",":","L-arginine","+","L-tyrosine","+","ATP","=","L-tyrosyl-L-arginine","+","AMP","+","diphosphate","+","2","H","(","+",")"),4264688). assertion_content_comment('oboGo_TyrosineBasedsiteSpecificrecombinaseactivity',s("Catalysis","of","the","formation","of","new","phosphodiester","bonds","between","a","pair","of","short",",","unique","DNA","target","sequences",";","occurs","through","a","phosphotyrosyl","intermediate","in","which","the","target","sequence","is","first","cleaved","by","the","nucleophilic","attack","by","a","tyrosine","in","the","active","site","."),4256901). assertion_content_comment('oboGo_TyrosineBiosyntheticProcessFromChorismateVia4Hydroxyphenylpyruvate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","tyrosine","from","other","compounds",",","including","chorismate",",","via","the","intermediate","4-hydroxyphenylpyruvate","."),4238647). assertion_content_comment('oboGo_TyrosineBiosyntheticProcessFromChorismateViaLArogenate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","tyrosine","from","other","compounds",",","including","chorismate",",","via","the","intermediate","L-arogenate","."),4340488). assertion_content_comment('oboGo_TyrosineEstersulfotransferaseactivity',s("Catalysis","of","the","reaction",":","3","'","-phospho-5","'","-adenylyl","sulfate","+","L-tyrosine","methyl","ester","=","L-tyrosine","methyl","ester","4-sulfate","+","adenosine","3","'",",","5","'","-diphosphate","+","H","(","+",")"),4269549). assertion_content_comment('oboGo_TyrosineNMonooxygenaseactivity',s("Catalysis","of","the","reaction",":","tyrosine","+","O2","+","NADPH","+","H","+","=","N-hydroxytyrosine","+","NADP","+","+","H2O","."),4264742). assertion_content_comment('oboGo_TyrosinePhenolLyaseactivity',s("Catalysis","of","the","reaction",":","L-tyrosine","+","H","(","2",")","O","=","NH","(","4",")","(","+",")","+","phenol","+","pyruvate","."),4264755). assertion_content_comment('oboGo_TyrosineTrnaligaseactivity',s("Catalysis","of","the","reaction",":","L-tyrosine","+","ATP","+","tRNA","(","Tyr",")","=","L-tyrosyl-tRNA","(","Tyr",")","+","AMP","+","diphosphate","+","2","H","(","+",")"),4199716). assertion_content_comment('oboGo_TyrosylDnaphosphodiesteraseactivity',s("Catalysis","of","the","hydrolysis","of","phosphotyrosyl","groups","formed","as","covalent","intermediates","(","in","DNA","backbone","breakage",")","between","a","DNA","topoisomerase","and","DNA","."),4174373). assertion_content_comment('oboGo_TyrosylTrnaaminoacylation',s("The","process","of","coupling","tyrosine","to","tyrosyl-tRNA",",","catalyzed","by","tyrosyl-tRNA","synthetase",".","In","tRNA","aminoacylation",",","the","amino","acid","is","first","activated","by","linkage","to","AMP","and","then","transferred","to","either","the","2","'","-","or","the","3","'","-hydroxyl","group","of","the","3","'","-adenosine","residue","of","the","tRNA","."),4179221). assertion_content_comment('oboGo_U12Typecatalyticstep1spliceosome',s("A","spliceosomal","complex","that","is","formed","by","the","displacement","of","the","U11","and","U4atac","snRNPs","from","the","precatalytic","spliceosome",";","the","U12",",","U5","and","U6atac","snRNPs","remain","associated","with","the","mRNA",".","This","complex",",","sometimes","called","the","activated","spliceosome",",","is","the","catalytically","active","form","of","the","spliceosome",",","and","includes","many","proteins","in","addition","to","those","found","in","the","U12",",","and","U5","and","U6atac","snRNPs","."),4167858). assertion_content_comment('oboGo_U12Typecatalyticstep2spliceosome',s("A","spliceosomal","complex","that","contains","the","U12",",","U5","and","U6atac","snRNPs","bound","to","a","splicing","intermediate","in","which","the","first","catalytic","cleavage","of","the","5","'","splice","site","has","occurred",".","The","precise","subunit","composition","differs","significantly","from","that","of","the","catalytic","step","1",",","or","activated",",","spliceosome",",","and","includes","many","proteins","in","addition","to","those","found","in","the","U12",",","U5","and","U6atac","snRNPs","."),4167793). assertion_content_comment('oboGo_U12TypepostMrnareleasespliceosomalcomplex',s("A","spliceosomal","complex","that","is","formed","following","the","release","of","the","spliced","product","from","the","post-spliceosomal","complex","and","contains","the","excised","intron","and","the","U12",",","U5","and","U6atac","snRNPs","."),4167830). assertion_content_comment('oboGo_U12TypepostSpliceosomalcomplex',s("A","spliceosomal","complex","that","is","formed","following","the","second","splicing","event","and","contains","the","spliced","product",",","the","excised","intron",",","and","three","snRNPs",",","including","U5","."),4167885). assertion_content_comment('oboGo_U12Typeprecatalyticspliceosome',s("A","spliceosomal","complex","that","is","formed","by","the","recruitment","of","the","preassembled","U4atac/U6atac.U5","tri-snRNP","to","the","U12-type","prespliceosome",".","Although","all","5","snRNPs","are","present",",","the","precatalytic","spliceosome","is","catalytically","inactive",".","The","precatalytic","spliceosome","includes","many","proteins","in","addition","to","those","found","in","the","U11",",","U12","and","U4atac/U6atac.U5","snRNPs","."),4167843). assertion_content_comment('oboGo_U12Typeprespliceosome',s("A","spliceosomal","complex","that","is","formed","by","the","cooperative","binding","of","the","heterodimeric","U11/U12","snRNP","to","the","5","'","splice","site","and","the","branch","point","sequence",".","The","U12-type","prespliceosome","includes","many","proteins","in","addition","to","those","found","in","the","U11/U12","heterodimeric","snRNPs",".","Commitment","to","a","given","pair","of","5","'","and","3","'","splice","sites","occurs","at","the","time","of","prespliceosome","formation","."),4167779). assertion_content_comment('oboGo_U12Typespliceosomalcomplex',s("Any","spliceosomal","complex","that","forms","during","the","splicing","of","a","messenger","RNA","primary","transcript","to","excise","an","intron",";","the","series","of","U12-type","spliceosomal","complexes","is","involved","in","the","splicing","of","the","majority","of","introns","that","contain","atypical","AT-AC","terminal","dinucleotides",",","as","well","as","other","non-canonical","introns",".","The","entire","splice","site","signal",",","not","just","the","terminal","dinucleotides",",","is","involved","in","determining","which","spliceosome","utilizes","the","site","."),4167773). assertion_content_comment('oboGo_U1SnRNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","a","U1","snRNA","molecule","."),4357620). assertion_content_comment('oboGo_U2SnRNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","a","U2","snRNA","molecule","."),4357610). assertion_content_comment('oboGo_U2Typecatalyticstep1spliceosome',s("A","spliceosomal","complex","that","is","formed","by","the","displacement","of","the","U1","and","U4","snRNPs","from","the","precatalytic","spliceosome",";","the","U2",",","U5","and","U6","snRNPs","remain","associated","with","the","mRNA",".","This","complex",",","sometimes","called","the","activated","spliceosome",",","is","the","catalytically","active","form","of","the","spliceosome",",","and","includes","many","proteins","in","addition","to","those","found","in","the","U2",",","and","U5","and","U6","snRNPs","."),4167701). assertion_content_comment('oboGo_U2Typecatalyticstep2spliceosome',s("A","spliceosomal","complex","that","contains","the","U2",",","U5","and","U6","snRNPs","bound","to","a","splicing","intermediate","in","which","the","first","catalytic","cleavage","of","the","5","'","splice","site","has","occurred",".","The","precise","subunit","composition","differs","significantly","from","that","of","the","catalytic","step","1",",","or","activated",",","spliceosome",",","and","includes","many","proteins","in","addition","to","those","found","in","the","U2",",","U5","and","U6","snRNPs","."),4167729). assertion_content_comment('oboGo_U2TypepostMrnareleasespliceosomalcomplex',s("A","spliceosomal","complex","that","is","formed","following","the","release","of","the","spliced","product","from","the","post-spliceosomal","complex","and","contains","the","excised","intron","and","the","U2",",","U5","and","U6","snRNPs","."),4167754). assertion_content_comment('oboGo_U2TypepostSpliceosomalcomplex',s("A","spliceosomal","complex","that","is","formed","following","the","second","splicing","event","and","contains","the","spliced","product",",","the","excised","intron",",","and","three","snRNPs",",","including","U5","."),4167899). assertion_content_comment('oboGo_U2Typeprecatalyticspliceosome',s("A","spliceosomal","complex","that","is","formed","by","the","recruitment","of","the","preassembled","U4/U6.U5","tri-snRNP","to","the","prespliceosome",".","Although","all","5","snRNPs","are","present",",","the","precatalytic","spliceosome","is","catalytically","inactive",".","The","precatalytic","spliceosome","includes","many","proteins","in","addition","to","those","found","in","the","U1",",","U2","and","U4/U6.U5","snRNPs","."),4167673). assertion_content_comment('oboGo_U2Typeprespliceosome',s("A","spliceosomal","complex","that","is","formed","by","association","of","the","5","'","splice","site","with","the","U1","snRNP",",","while","the","branch","point","sequence","is","recognized","by","the","U2","snRNP",".","The","prespliceosome","includes","many","proteins","in","addition","to","those","found","in","the","U1","and","U2","snRNPs",".","Commitment","to","a","given","pair","of","5","'","and","3","'","splice","sites","occurs","at","the","time","of","prespliceosome","formation","."),4167647). assertion_content_comment('oboGo_U2Typespliceosomalcomplex',s("Any","spliceosomal","complex","that","forms","during","the","splicing","of","a","messenger","RNA","primary","transcript","to","excise","an","intron","that","has","canonical","consensus","sequences","near","the","5","'","and","3","'","ends","."),4167630). assertion_content_comment('oboGo_U4atacU6atacXU5TriSnrnpcomplex',s("A","ribonucleoprotein","complex","formed","by","the","association","of","the","U4atac/U6atac","and","U5","small","nuclear","ribonucleoproteins","."),4167585). assertion_content_comment('oboGo_U4SnRNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","a","U4","snRNA","molecule","."),4357640). assertion_content_comment('oboGo_U4U6XU5TriSnrnpcomplex',s("A","ribonucleoprotein","complex","formed","by","the","association","of","the","U4/U6","and","U5","small","nuclear","ribonucleoproteins","."),4359004). assertion_content_comment('oboGo_U5SnRNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","a","U5","snRNA","molecule","."),4357630). assertion_content_comment('oboGo_U6SnRNA3Endbinding',s("Interacting","selectively","and","non-covalently","with","the","3","'","end","of","the","U6","small","nuclear","RNA","(","U6","snRNA",")"),4307958). assertion_content_comment('oboGo_U6SnRNA3Endprocessing',s("Any","process","involved","in","forming","the","mature","3","'","end","of","a","U6","snRNA","molecule","."),4357591). assertion_content_comment('oboGo_UAACodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UAA","codon","."),4340087). assertion_content_comment('oboGo_UACCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UAC","codon","."),4340098). assertion_content_comment('oboGo_UAGCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UAG","codon","."),4340076). assertion_content_comment('oboGo_UAUCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UAU","codon","."),4340110). assertion_content_comment('oboGo_UBC13Mms2complex',s("A","heterodimeric","ubiquitin","conjugating","enzyme","complex","that","catalyzes","assembly","of","K63-linked","polyubiquitin","chains",",","which","act","as","a","signal","to","promote","error-free","DNA","postreplication","repair",";","in","Saccharomyces","the","complex","comprises","Ubc13p","and","Mms2p","."),4319716). assertion_content_comment('oboGo_UBC13Uev1acomplex',s("A","heterodimeric","ubiquitin","conjugating","enzyme","complex","that","catalyzes","assembly","of","K63-linked","polyubiquitin","chains","and","is","involved","in","NF-kappaB","activation",".","In","humans","at","least",",","the","complex","comprises","the","ubiquitin-conjugating","enzyme","UBC13","and","ubiquitin-conjugating","enzyme","variant","1A","(","UEV1A",")"),4382959). assertion_content_comment('oboGo_UbiquinolCytochromeCreductaseactivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","CoQH2","+","2","ferricytochrome","c","=","CoQ","+","2","ferrocytochrome","c","+","2","H","+"),4246726). assertion_content_comment('oboGo_UbiquinoneBiosyntheticProcessVia2Polyprenylphenol',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ubiquinone",",","via","the","intermediates","2-polyprenylphenol","and","2-polyprenyl-6-hydroxyphenol","."),4329432). assertion_content_comment('oboGo_UbiquinoneBiosyntheticProcessVia34_Dihydroxy_5_Polyprenylbenzoate',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","ubiquinone",",","via","the","intermediates","3",",","4-dihydroxy-5-polyprenylbenzoate","and","3-methoxy-4-hydroxy-5-polyprenylbenzoate","."),4329423). assertion_content_comment('oboGo_UbiquitinCalmodulinligaseactivity',s("Catalysis","of","the","reaction",":","n","ATP","+","calmodulin","+","n","ubiquitin","=","n","AMP","+","n","diphosphate","+","ubiquitin","(","n",")","-calmodulin","."),4264781). assertion_content_comment('oboGo_UbiquitinDependentendocytosis',s("Endocytosis","of","a","protein","that","requires","the","substrate","to","be","modified","by","uniquitination",".","Several","plasma","membrane","proteins",",","including","cell","surface","permeases","and","some","receptors",",","are","targeted","for","internalization","by","endocytosis",",","and","are","thereafter","delivered","to","the","vacuole","or","lysosome",",","where","they","are","degraded","."),4142485). assertion_content_comment('oboGo_UbiquitinDependentproteincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","by","hydrolysis","of","its","peptide","bonds",",","initiated","by","the","covalent","attachment","of","a","ubiquitin","group",",","or","multiple","ubiquitin","groups",",","to","the","protein","."),4012061). assertion_content_comment('oboGo_UbiquitinDependentproteincatabolicprocessviathemultivesicularbodysortingpathway',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","covalently","tagged","with","ubiquitin",",","via","the","multivesicular","body","(","MVB",")","sorting","pathway",";","ubiquitin-tagged","proteins","are","sorted","into","MVBs",",","and","delivered","to","a","lysosome/vacuole","for","degradation","."),4095608). assertion_content_comment('oboGo_UbiquitinDependentproteincatabolicprocessviathenEndrulepathway',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","a","protein","or","peptide","covalently","tagged","with","ubiquitin",",","via","the","N-end","rule","pathway",".","In","the","N-end","rule","pathway",",","destabilizing","N-terminal","residues","(","N-degrons",")","in","substrates","are","recognized","by","E3","ligases","(","N-recognins",")",",","whereupon","the","substrates","are","linked","to","ubiquitin","and","then","delivered","to","the","proteasome","for","degradation","."),4172006). assertion_content_comment('oboGo_UbiquitinDependentsmadproteincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","SMAD","signaling","proteins","by","ubiquitination","and","targeting","to","the","proteasome","."),4046526). assertion_content_comment('oboGo_UbiquitinLikehydrolaseactivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4234177). assertion_content_comment('oboGo_UbiquitinProteinligaseactivatoractivity',s("Increases","the","activity","of","a","ubiquitin-protein","ligase",",","an","enzyme","that","catalyzes","the","covalent","attachment","of","ubiquitin","to","lysine","in","a","substrate","protein","."),4074101). assertion_content_comment('oboGo_UbiquitinProteinligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","ubiquitin","+","protein","lysine","=","AMP","+","diphosphate","+","protein","N-ubiquityllysine","."),4155394). assertion_content_comment('oboGo_UbiquitinProteinligaseinhibitoractivity',s("Stops",",","prevents","or","reduces","the","activity","of","a","ubiquitin-protein","ligase","."),4222189). assertion_content_comment('oboGo_UbiquitinProteinligaseregulatoractivity',s("Modulates","the","activity","of","a","ubiquitin-protein","ligase",",","an","enzyme","that","catalyzes","the","covalent","attachment","of","ubiquitin","to","lysine","in","a","substrate","protein","."),4074099). assertion_content_comment('oboGo_UbiquitinRibosomalproteinfusionprotein',s("OBSOLETE",".","A","protein","encoded","by","some","ubiquitin","genes","which","consists","of","a","single","copy","of","ubiquitin","fused","to","a","ribosomal","protein","."),4218178). assertion_content_comment('oboGo_UbiquitinSpecificprotease5activity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","the","Gly76-Lys48","isopeptide","bond","of","polyubiquitin","."),4252955). assertion_content_comment('oboGo_UbiquitinSpecificproteaseactivatoractivity',s("Increases","the","activity","of","a","ubiquitin-specific","protease",",","an","enzyme","that","catalyzes","the","hydrolysis","of","various","forms","of","polymeric","ubiquitin","sequences","."),4370489). assertion_content_comment('oboGo_UbiquitinSpecificproteaseactivity',s("Catalysis","of","the","hydrolysis","of","various","forms","of","polymeric","ubiquitin","sequences","."),4199543). assertion_content_comment('oboGo_UbiquitinUbiquitinligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","ubiquitin","+","protein","N-ubiquityl","(","n",")","lysine","=","AMP","+","diphosphate","+","protein","N-ubiquityl","(","n","+","1",")","lysine",".","This","reaction","is","the","ligation","of","ubiquitin","groups",",","via","isopeptide","bonds",",","to","extend","the","length","of","the","multiubiquitin","chain","attached","to","a","substrate","protein","."),4357167). assertion_content_comment('oboGo_UCACodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UCA","codon","."),4340122). assertion_content_comment('oboGo_UCCCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UCC","codon","."),4340158). assertion_content_comment('oboGo_UCGCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UCG","codon","."),4340134). assertion_content_comment('oboGo_UCUCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UCU","codon","."),4340146). assertion_content_comment('oboGo_UDP_23_DiacylglucosamineHydrolaseActivity',s("Catalysis","of","the","reaction",":","H2O","+","UDP-2",",","3-bis","(","3-hydroxymyristoyl",")","glucosamine","=","2",",","3-bis","(","3-hydroxymyristoyl",")","-beta-D-glucosaminyl","1-phosphate","+","UMP","."),4251504). assertion_content_comment('oboGo_UDP_2_Acetamido_4_Amino_246_TrideoxyglucoseTransaminaseActivity',s("Catalysis","of","the","reaction",":","2-oxoglutarate","+","UDP-2-acetamido-4-amino-2",",","4",",","6-trideoxy-D-glucose","=","L-glutamate","+","UDP-2-acetamido-4-dehydro-2",",","6-dideoxy-beta-D-glucose","."),4369197). assertion_content_comment('oboGo_UDP_3_O_3_HydroxymyristoylGlucosamineN_AcyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-3-O-","(","3-hydroxytetradecanoyl",")","glucosamine","+","(","R",")","-3-hydroxytetradecanoyl-","[","acyl-carrier","protein","]","=","UDP-2",",","3-bis","(","3-hydroxytetradecanoyl",")","glucosamine","+","[","acyl-carrier","protein","]"),4326118). assertion_content_comment('oboGo_UDP_3_O_3_HydroxymyristoylN_AcetylglucosamineDeacetylaseActivity',s("Catalysis","of","the","removal","of","an","acetyl","group","from","the","2-N","position","of","glucosamine","in","the","lipid","A","precursor","UDP-3-O-","(","R-3-hydroxymyristoyl",")","-N-acetylglucosamine","."),4251466). assertion_content_comment('oboGo_UDP_4_Keto_6_Deoxy_Glucose_35_EpimeraseActivity',s("Catalysis","of","the","reaction",":","UDP-4-keto-6-deoxyglucose","=","UDP-4-keto-rhamnose","."),4332812). assertion_content_comment('oboGo_UDP_4_Keto_Rhamnose_4_Keto_ReductaseActivity',s("Catalysis","of","the","reaction",":","UDP-4-keto-rhamnose","+","NADPH","=","UDP-rhamnose","+","NADP","+"),4332725). assertion_content_comment('oboGo_UDPActivatednucleotidereceptoractivity',s("Combining","with","a","nucleotide","and","transmitting","the","signal","to","a","heterotrimeric","G-protein","complex","to","initiate","a","change","in","cell","activity",",","activated","by","UDP","."),4300733). assertion_content_comment('oboGo_UDPArabinose4Epimeraseactivity',s("Catalysis","of","the","reaction",":","UDP-L-arabinose","=","UDP-alpha-D-xylose","."),4264795). assertion_content_comment('oboGo_UDPDApiosebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-D-apiose",",","uridinediphosphoapicose",",","a","substance","composed","of","apiose","in","glycosidic","linkage","with","uridine","diphosphate","."),4338743). assertion_content_comment('oboGo_UDPDApiosemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-D-apiose",",","uridinediphosphoapiose",",","a","substance","composed","of","apiose","in","glycosidic","linkage","with","uridine","diphosphate","."),4338731). assertion_content_comment('oboGo_UDPDGalactosebiosyntheticprocess',s("The","chemical","reactions","and","pathways","involving","UDP-D-galactose",",","a","substance","composed","of","D-galactose","in","glycosidic","linkage","with","guanosine","diphosphate","."),4187294). assertion_content_comment('oboGo_UDPDGalactosemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-D-galactose",",","a","substance","composed","of","D-galactose","in","glycosidic","linkage","with","guanosine","diphosphate","."),4187252). assertion_content_comment('oboGo_UDPDGalacturonatebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-D-galacturonate",",","a","substance","composed","of","galacturonic","acid","in","glycosidic","linkage","with","uridine","diphosphate","."),4339375). assertion_content_comment('oboGo_UDPDGalacturonatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-D-galacturonate",",","a","substance","composed","of","galacturonic","acid","in","glycosidic","linkage","with","uridine","diphosphate","."),4339249). assertion_content_comment('oboGo_UDPDXylosebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-D-xylose",",","uridinediphosphoxylose",",","a","substance","composed","of","xylose","in","glycosidic","linkage","with","uridine","diphosphate","."),4339079). assertion_content_comment('oboGo_UDPDXylosemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-D-xylose",",","uridinediphosphoxylose",",","a","substance","composed","of","xylose","in","glycosidic","linkage","with","uridine","diphosphate","."),4339058). assertion_content_comment('oboGo_UDPGalactopyranosemutaseactivity',s("Catalysis","of","the","reaction",":","UDP-D-galactopyranose","=","UDP-D-galacto-1",",","4-furanose","."),4251632). assertion_content_comment('oboGo_UDP_Galactose_Beta_N_AcetylglucosamineBeta_13_GalactosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-galactose","+","N-acetylglucosamine","=","galactose-beta-1",",","3-N-acetylglucosamine","+","UDP","."),4254419). assertion_content_comment('oboGo_UDP_Galactose_GlucosylceramideBeta_14_GalactosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-D-galactose","+","a","glucosylceramide","=","a","lactosylceramide","+","uridine-5","'","-diphosphate",".","The","glucosylceramide","has","sphinganine","as","the","long","chain","base","."),4254331). assertion_content_comment('oboGo_UDP_Galactose_N_GlycanBeta_13_GalactosyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-galactose","+","N-glycan","=","galactose-beta-1",",","3-N-glycan","+","UDP","."),4332821). assertion_content_comment('oboGo_UDPGalactosetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","UDP-galactose","from","one","side","of","the","membrane","to","the","other",".","UDP-galactose","is","a","substance","composed","of","galactose","in","glycosidic","linkage","with","uridine","diphosphate","."),4219437). assertion_content_comment('oboGo_UDPGalactosetransmembranetransport',s("The","directed","movement","of","UDP-galactose","across","a","membrane","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore","."),4158277). assertion_content_comment('oboGo_UDPGalactosetransport',s("The","directed","movement","of","UDP-galactose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","UDP-galactose","is","a","substance","composed","of","galactose","in","glycosidic","linkage","with","uridine","diphosphate","."),4158274). assertion_content_comment('oboGo_UDPGalactoseUdpNAcetylglucosaminegalactosephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-alpha-D-glucosamine","+","UDP-D-galactose","=","H","(","+",")","+","UDP-N-acetyl-6-","(","D-galactose-1-phospho",")","-D-glucosamine","+","UMP","."),4368027). assertion_content_comment('oboGo_UDPGalactosyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","galactose","group","from","UDP-galactose","to","an","acceptor","molecule","."),4184675). assertion_content_comment('oboGo_UDPGalacturonatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","UDP-alpha-D-galacturonate","=","CO","(","2",")","+","UDP-L-arabinose","."),4264767). assertion_content_comment('oboGo_UDPGlucosamine4Epimeraseactivity',s("Catalysis","of","the","reaction",":","UDP-glucosamine","=","UDP-galactosamine","."),4265132). assertion_content_comment('oboGo_UDPGlucose46Dehydrataseactivity',s("Catalysis","of","the","reaction",":","UDP-D-glucose","=","H","(","2",")","O","+","UDP-4-dehydro-6-deoxy-D-glucose","."),4265143). assertion_content_comment('oboGo_UDPGlucose_4Aminobenzoateacylglucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","4-aminobenzoate","+","UDP-glucose","=","p-aminobenzoate-beta-D-glucopyranosyl","ester","+","UDP","."),4182862). assertion_content_comment('oboGo_UDPGlucose4Epimeraseactivity',s("Catalysis","of","the","reaction",":","UDP-glucose","=","UDP-galactose","."),4187391). assertion_content_comment('oboGo_UDPGlucose6Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","2","NAD","(","+",")","+","UDP-alpha-D-glucose","=","3","H","(","+",")","+","2","NADH","+","UDP-alpha-D-glucuronate","."),4187381). assertion_content_comment('oboGo_UDPGlucosecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","UDP-glucose",",","uridinediphosphoglucose",",","a","substance","composed","of","glucose","in","glycosidic","linkage","with","uridine","diphosphate","."),4038150). assertion_content_comment('oboGo_UDPGlucoseGlycoproteinglucosephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","glycoprotein","D-mannose","+","UDP-D-glucose","=","glycoprotein","6-","(","D-glucose-1-phospho",")","-D-mannose","+","UMP","."),4368011). assertion_content_comment('oboGo_UDPGlucose_Glycoproteinglucosyltransferaseactivity',s("Catalysis","of","the","addition","of","UDP-glucose","on","to","asparagine-linked","(","N-linked",")","oligosaccharides","of","the","form","Man7-9GlcNAc2","on","incorrectly","folded","glycoproteins","."),4187268). assertion_content_comment('oboGo_UDP_Glucose_Hexose_1_PhosphateUridylyltransferaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-galactose","1-phosphate","+","UDP-D-glucose","=","alpha-D-glucose","1-phosphate","+","UDP-D-galactose","."),4246389). assertion_content_comment('oboGo_UDPGlucosemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-glucose",",","uridinediphosphoglucose",",","a","substance","composed","of","glucose","in","glycosidic","linkage","with","uridine","diphosphate","."),4038117). assertion_content_comment('oboGo_UDPGlucosetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","UDP-glucose","from","one","side","of","the","membrane","to","the","other",".","UDP-glucose","is","a","substance","composed","of","glucose","in","glycosidic","linkage","with","uridine","diphosphate","."),4219596). assertion_content_comment('oboGo_UDPGlucosetransport',s("The","directed","movement","of","UDP-glucose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","UDP-glucose","is","a","substance","composed","of","glucose","in","glycosidic","linkage","with","uridine","diphosphate","."),4291329). assertion_content_comment('oboGo_UDPGlucosyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","glucosyl","group","from","UDP-glucose","to","an","acceptor","molecule","."),4182002). assertion_content_comment('oboGo_UDPGlucuronate4Epimeraseactivity',s("Catalysis","of","the","reaction",":","UDP-alpha-D-glucuronate","=","UDP-alpha-D-galacturonate","."),4265158). assertion_content_comment('oboGo_UDPGlucuronate5Epimeraseactivity',s("Catalysis","of","the","reaction",":","UDP-alpha-D-glucuronate","=","UDP-L-iduronate","."),4265175). assertion_content_comment('oboGo_UDPGlucuronatebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-glucuronate",",","a","substance","composed","of","glucuronic","acid","in","glycosidic","linkage","with","uridine","diphosphate","."),4224916). assertion_content_comment('oboGo_UDPGlucuronatedecarboxylaseactivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","UDP-alpha-D-glucuronate","=","CO","(","2",")","+","UDP-alpha-D-xylose","."),4384576). assertion_content_comment('oboGo_UDPGlucuronatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-glucuronate",",","a","substance","composed","of","glucuronic","acid","in","glycosidic","linkage","with","uridine","diphosphate","."),4224896). assertion_content_comment('oboGo_UDPGlucuronicacidtransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","UDP-glucuronic","acid","from","one","side","of","the","membrane","to","the","other",".","UDP-glucuronic","acid","is","a","substance","composed","of","glucuronic","acid","in","glycosidic","linkage","with","uridine","diphosphate","."),4219587). assertion_content_comment('oboGo_UDPGlucuronicacidtransport',s("The","directed","movement","of","UDP-glucuronic","acid","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","UDP-glucuronic","acid","is","a","substance","composed","of","glucuronic","acid","in","glycosidic","linkage","with","uridine","diphosphate","."),4291338). assertion_content_comment('oboGo_UDPGlycosyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","glycosyl","group","from","a","UDP-sugar","to","a","small","hydrophobic","molecule","."),4181725). assertion_content_comment('oboGo_UDPLArabinosebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-L-arabinose",",","uridinediphosphoarabinose",",","a","substance","composed","of","arabinose","in","glycosidic","linkage","with","uridine","diphosphate","."),4338802). assertion_content_comment('oboGo_UDPLArabinosemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-L-arabinose",",","uridinediphosphoarabinose",",","a","substance","composed","of","arabinose","in","glycosidic","linkage","with","uridine","diphosphate","."),4338778). assertion_content_comment('oboGo_UDPLRhamnosesynthaseactivity',s("Catalysis","of","the","reaction",":","UDP-D-glucose","+","NADPH","+","H","+","=","UDP-L-rhamnose","+","NADP","+","+","H2O","."),4335232). assertion_content_comment('oboGo_UDP_N_Acetyl_D_Glucosamine_N_Acetylmuramoyl_L_Alanyl_D_Glutamyl_Meso_26_Diaminopimelyl_D_Alanyl_D_Alanine_Diphosphoundecaprenol4_Beta_N_AcetylglucosaminlytransferaseActivity',s("Catalysis","of","the","reaction",":","N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2",",","6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol","+","UDP-N-acetyl-D-glucosamine","=","N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2",",","6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine","+","UDP","."),4183478). assertion_content_comment('oboGo_UDP_N_Acetylgalactosamine_4_SulfateSulfotransferaseActivity',s("Catalysis","of","the","reaction",":","3","'","-phospho-5","'","-adenylyl","sulfate","+","UDP-N-acetyl-D-galactosamine","4-sulfate","=","adenosine","3","'",",","5","'","-diphosphate","+","H","(","+",")","+","UDP-N-acetyl-D-galactosamine","4",",","6-disulfate","."),4367923). assertion_content_comment('oboGo_UDPNAcetylgalactosaminebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-N-acetylgalactosamine",",","a","substance","composed","of","N-acetylgalactosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4238857). assertion_content_comment('oboGo_UDPNAcetylgalactosaminecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","UDP-N-acetylgalactosamine",",","a","substance","composed","of","N-acetylgalactosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4238817). assertion_content_comment('oboGo_UDPNAcetylgalactosaminediphosphorylaseactivity',s("Catalysis","of","the","reaction",":","UTP","+","N-acetyl-alpha-D-galactosamine","1-phosphate","=","diphosphate","+","UDP-N-acetyl-D-galactosamine","."),4191144). assertion_content_comment('oboGo_UDPNAcetylgalactosaminemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-N-acetylgalactosamine",",","a","substance","composed","of","N-acetylgalactosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4238813). assertion_content_comment('oboGo_UDP_N_Acetylgalactosamine_N_Acetylneuraminyl_Alpha_23_Galactosyl_Beta_R14_N_AcetylgalactosaminyltransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-N-acetylgalactosamine","+","N-acetylneuraminyl-alpha-2",",","3-galactosyl-beta-oligosaccharide","=","UDP","+","N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2",",","3-galactosyl-beta-oligosaccharide","."),4338095). assertion_content_comment('oboGo_UDPNAcetylgalactosaminetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","N-acetylgalactosamine","from","one","side","of","the","membrane","to","the","other",".","N-acetylgalactosamine","is","a","substance","composed","of","N-acetylgalactosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4219560). assertion_content_comment('oboGo_UDPNAcetylgalactosaminetransport',s("The","directed","movement","of","UDP-N-acetylgalactosamine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","UDP-N-acetylgalactosamine","is","a","substance","composed","of","N-acetylgalactosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4291320). assertion_content_comment('oboGo_UDPNAcetylglucosamine1Carboxyvinyltransferaseactivity',s("Catalysis","of","the","reaction",":","phosphoenolpyruvate","+","UDP-N-acetyl-alpha-D-glucosamine","=","phosphate","+","UDP-N-acetyl-3-O-","(","1-carboxyvinyl",")","-D-glucosamine","."),4251644). assertion_content_comment('oboGo_UDPNAcetylglucosamine2Epimeraseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-D-glucosamine","=","UDP-N-acetyl-D-mannosamine","."),4251668). assertion_content_comment('oboGo_UDPNAcetylglucosamine4Epimeraseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-D-glucosamine","=","UDP-N-acetyl-D-galactosamine","."),4186774). assertion_content_comment('oboGo_UDPNAcetylglucosamine6Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","H","(","2",")","O","+","2","NAD","(","+",")","+","UDP-N-acetyl-alpha-D-glucosamine","=","3","H","(","+",")","+","2","NADH","+","UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate","."),4364506). assertion_content_comment('oboGo_UDPNAcetylglucosaminebiosynthesisinvolvedinchitinbiosynthesis',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-N-acetylglucosamine",",","a","substance","composed","of","N-acetylglucosamine","in","glycosidic","linkage","with","uridine","diphosphate",",","that","contribute","to","the","biosynthesis","of","chitin","."),4084293). assertion_content_comment('oboGo_UDPNAcetylglucosaminebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-N-acetylglucosamine",",","a","substance","composed","of","N-acetylglucosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4084284). assertion_content_comment('oboGo_UDPNAcetylglucosaminecatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","UDP-N-acetylglucosamine",",","a","substance","composed","of","N-acetylglucosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4224620). assertion_content_comment('oboGo_UDPNAcetylglucosaminediphosphorylaseactivity',s("Catalysis","of","the","reaction",":","N-acetyl-alpha-D-glucosamine","1-phosphate","+","UTP","=","diphosphate","+","UDP-N-acetyl-alpha-D-glucosamine","."),4186829). assertion_content_comment('oboGo_UDPNAcetylglucosamineDolichylPhosphatenAcetylglucosaminephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-D-glucosamine","+","dolichyl","phosphate","=","UMP","+","N-acetyl-D-glucosaminyl-diphosphodolichol","."),4186790). assertion_content_comment('oboGo_UDPNAcetylglucosamineLysosomalEnzymenAcetylglucosaminephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetyl-D-glucosamine","+","lysosomal-enzyme","D-mannose","=","UMP","+","lysosomal-enzyme","N-acetyl-D-glucosaminyl-phospho-D-mannose","."),4186811). assertion_content_comment('oboGo_UDPNAcetylglucosamineLysosomalEnzymenAcetylglucosaminephosphotransferasecomplex',s("A","protein","complex","that","possesses","UDP-N-acetylglucosamine-lysosomal-enzyme","N-acetylglucosaminephosphotransferase","activity",";","the","bovine","complex","contains","disulfide-linked","homodimers","of","166-","and","51-kDa","subunits","and","two","identical",",","noncovalently","associated","56-kDa","subunits","."),4130975). assertion_content_comment('oboGo_UDPNAcetylglucosaminemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-N-acetylglucosamine",",","a","substance","composed","of","N-acetylglucosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4084281). assertion_content_comment('oboGo_UDP_N_Acetylglucosamine_Serine_ProteinN_Acetylglucosamine_1_PhosphotransferaseActivity',s("Catalysis","of","the","transfer","of","N-acetylglucosamine-1-phosphate","to","a","serine","residue","in","a","protein","."),4281797). assertion_content_comment('oboGo_UDPNAcetylglucosaminetransferasecomplex',s("A","multienzyme",",","heterooligomeric","complex","involved","in","dolichyl-linked","oligosaccharide","synthesis",".","In","yeast","the","complex","is","composed","of","Alg7p",",","which","catalyzes","the","first","step","(","GlcNAc1-PP-Dol","from","dolichol-phosphate","and","UDP-GlcNAc",")",",","and","Alg13p","plus","Alg14p",",","the","catalytic","and","anchoring","subunits","respectively",",","which","together","catalyze","the","second","step","(","GlcNAc2-PP-dolichol","from","GlcNAc1-PP-Dol","and","UDP-GlcNAc",")","of","dolichyl-linked","oligosaccharide","synthesis","."),4094382). assertion_content_comment('oboGo_UDPNAcetylglucosaminetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","a","UDP-N-acetylglucosamine","from","one","side","of","the","membrane","to","the","other",".","N-acetylglucosamine","is","a","substance","composed","of","N-acetylglucosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4219569). assertion_content_comment('oboGo_UDPNAcetylglucosaminetransport',s("The","directed","movement","of","UDP-N-acetylglucosamine","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","N-acetylglucosamine","is","a","substance","composed","of","N-acetylglucosamine",",","a","common","structural","unit","of","oligosaccharides",",","in","glycosidic","linkage","with","uridine","diphosphate","."),4291311). assertion_content_comment('oboGo_UDPNAcetylmuramatedehydrogenaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetylmuramate","+","NADP","+","=","UDP-N-acetyl-3-O-","(","1-carboxyvinyl",")","-D-glucosamine","+","NADPH","+","H","+"),4251716). assertion_content_comment('oboGo_UDPNAcetylmuramateLAlanineligaseactivity',s("Catalysis","of","the","reaction",":","L-alanine","+","ATP","+","UDP-N-acetylmuramate","=","ADP","+","2","H","(","+",")","+","phosphate","+","UDP-N-acetylmuramoyl-L-alanine","."),4251734). assertion_content_comment('oboGo_UDPNAcetylmuramoylalanineDGlutamateligaseactivity',s("Catalysis","of","the","reaction",":","D-glutamate","+","ATP","+","UDP-N-acetylmuramoyl-L-alanine","=","ADP","+","2","H","(","+",")","+","phosphate","+","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate","."),4251684). assertion_content_comment('oboGo_UDP_N_Acetylmuramoylalanyl_D_Glutamate_26_DiaminopimelateLigaseActivity',s("Catalysis","of","the","reaction",":","meso-2",",","6-diaminopimelate","+","ATP","+","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate","=","ADP","+","2","H","(","+",")","+","phosphate","+","UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2",",","6-diaminoheptanedioate","."),4251701). assertion_content_comment('oboGo_UDP_N_Acetylmuramoylalanyl_D_Glutamyl_26_Diaminopimelate_D_Alanyl_D_AlanineLigaseActivity',s("Catalysis","of","the","reaction",":","ATP","+","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2",",","6-diaminoheptanedioate","+","D-alanyl-D-alanine","=","ADP","+","phosphate","+","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine","."),4251622). assertion_content_comment('oboGo_UDPNAcetylmuramoylLAlanylDGlutamateLLysineligaseactivity',s("Catalysis","of","the","reaction",":","L-lysine","+","ATP","+","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate","=","ADP","+","2","H","(","+",")","+","phosphate","+","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine","."),4369774). assertion_content_comment('oboGo_UDP_N_Acetylmuramoyl_L_Alanyl_D_Glutamyl_Meso_26_Diaminopimelyl_D_Alanyl_D_Alanine_Undecaprenyl_PhosphateTransferaseActivity',s("Catalysis","of","the","reaction",":","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2",",","6-diaminopimelyl-D-alanyl-D-alanine","+","di-trans",",","poly-cis-undecaprenyl","phosphate","=","UMP","+","N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2",",","6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol","."),4183455). assertion_content_comment('oboGo_UDPNAcetylmuramoylpentapeptideLysinen6Alanyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine","+","L-alanyl-tRNA","=","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-","(","L-alanyl",")","-L-lysyl-D-alanyl-D-alanine","+","tRNA","."),4367776). assertion_content_comment('oboGo_UDPNAcetylmuramoylTripeptideDAlanylDAlanineligaseactivity',s("Catalysis","of","the","reaction",":","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine","+","ATP","+","D-alanyl-D-alanine","=","phosphate","+","UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine","+","ADP","."),4369802). assertion_content_comment('oboGo_UDPRhamnosebiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","UDP-L-rhamnose",",","a","substance","composed","of","rhamnose","in","glycosidic","linkage","with","uridine","diphosphate","."),4335491). assertion_content_comment('oboGo_UDPRhamnosemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","UDP-L-rhamnose",",","a","substance","composed","of","rhamnose","in","glycosidic","linkage","with","uridine","diphosphate","."),4335488). assertion_content_comment('oboGo_UDPSugardiphosphataseactivity',s("Catalysis","of","the","reaction",":","UDP-sugar","+","H2O","=","UMP","+","sugar","1-phosphate","."),4251587). assertion_content_comment('oboGo_UDPSulfoquinovose_Dagsulfoquinovosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-sulfoquinovose","+","1",",","2-diacylglycerol","=","sulfoquinovosyldiacylglycerol","+","UDP","."),4359230). assertion_content_comment('oboGo_UDPXylosetransmembranetransporteractivity',s("Catalysis","of","the","transfer","of","UDP-xylose","from","one","side","of","the","membrane","to","the","other",".","UDP-xylose","is","a","substance","composed","of","xylose","in","glycosidic","linkage","with","uridine","diphosphate","."),4219578). assertion_content_comment('oboGo_UDPXylosetransport',s("The","directed","movement","of","UDP-xylose","into",",","out","of","or","within","a","cell",",","or","between","cells",",","by","means","of","some","agent","such","as","a","transporter","or","pore",".","UDP-xylose","is","a","substance","composed","of","xylose","in","glycosidic","linkage","with","uridine","diphosphate","."),4291000). assertion_content_comment('oboGo_UDPXylosyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","xylosyl","group","from","UDP-xylose","to","an","acceptor","molecule","."),4267301). assertion_content_comment('oboGo_UFPSpecifictranscriptionfactormrnaprocessinginvolvedinendoplasmicreticulumunfoldedproteinresponse',s("The","spliceosome-independent","cleavage","and","ligation","of","the","mRNA","encoding","a","UFP-specific","transcription","factor","to","remove","a","single","intron",",","thereby","increasing","both","the","translational","efficiency","of","the","processed","mRNA","and","the","activity","of","the","protein","it","encodes","."),4061085). assertion_content_comment('oboGo_UGACodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UGA","codon","."),4340287). assertion_content_comment('oboGo_UGCCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UGC","codon","."),4340275). assertion_content_comment('oboGo_UGGCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UGG","codon","."),4340298). assertion_content_comment('oboGo_UGUCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UGU","codon","."),4340064). assertion_content_comment('oboGo_ULK1Atg13Fip200complex',s("A","protein","complex","that","is","essential","for","mammalian","autophagy",",","and","consists","of","at","least","3","proteins",":","ULK1",",","ATG13","and","RB1CC1","(","FIP200",")","This","complex","is","the","mammalian","counterpart","of","Atg1-Atg13-Atg17","in","yeast","."),4178000). assertion_content_comment('oboGo_UndecaprenylDiphosphataseactivity',s("Catalysis","of","the","reaction",":","all-trans-undecaprenyl","diphosphate","+","H","(","2",")","O","=","all-trans-undecaprenyl","phosphate","+","H","(","+",")","+","phosphate","."),4265235). assertion_content_comment('oboGo_UndecaprenyldiphosphoMuramoylpentapeptidebetaNAcetylglucosaminyltransferaseactivity',s("Catalysis","of","the","reaction",":","Mur2Ac","(","oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala",")","-diphosphoundecaprenol","+","UDP-N-acetyl-D-glucosamine","=","GlcNAc-","(","1",",","4",")","-Mur2Ac","(","oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala",")","-diphosphoundecaprenol","+","UDP","."),4269126). assertion_content_comment('oboGo_UndecaprenylPhosphategalactosephosphotransferaseactivity',s("Catalysis","of","the","reaction",":","all-trans-undecaprenyl","phosphate","+","UDP-D-galactose","=","alpha-D-galactosyl-diphosphoundecaprenol","+","UMP","."),4367869). assertion_content_comment('oboGo_UndecaprenylPhosphatemannosyltransferaseactivity',s("Catalysis","of","the","reaction",":","all-trans-undecaprenyl","phosphate","+","GDP-alpha-D-mannose","=","D-mannosyl","undecaprenyl","phosphate","+","GDP","."),4367118). assertion_content_comment('oboGo_UnfoldedProteinResponseCleavageOfPrimaryTranscriptEncodingUFPSpecifictranscriptionfactor',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4232434). assertion_content_comment('oboGo_UnfoldedProteinResponseLigationOfMRNAEncodingUFPSpecifictranscriptionfactorbyrnaligase',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4232422). assertion_content_comment('oboGo_UPlasminogenactivatorreceptoractivity',s("Combining","with","the","urokinase","plasminogen","activator","to","initiate","a","change","in","cell","activity","."),4309742). assertion_content_comment('oboGo_Uracil_5_CarboxylateDecarboxylaseActivity',s("Catalysis","of","the","reaction",":","H","(","+",")","+","uracil","5-carboxylate","=","CO","(","2",")","+","uracil","."),4265250). assertion_content_comment('oboGo_UracilDNANGlycosylaseactivity',s("Catalysis","of","the","cleavage","of","the","N-C1","'","glycosidic","bond","between","the","damaged","DNA","base","and","the","deoxyribose","sugar",",","releasing","a","free","base","and","leaving","an","apyrimidinic","(","AP",")","site",".","Enzymes","with","this","activity","recognize","and","remove","uracil","bases","in","DNA","that","result","from","the","deamination","of","cytosine","or","the","misincorporation","of","dUTP","opposite","an","adenine","."),4199531). assertion_content_comment('oboGo_UrateRibonucleotidephosphorylaseactivity',s("Catalysis","of","the","reaction",":","3-","(","beta-D-ribofuranosyl",")","uric","acid","+","phosphate","=","alpha-D-ribose","1-phosphate","+","H","(","+",")","+","urate","."),4265190). assertion_content_comment('oboGo_UreaTransportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","urea","(","out",")","=","ADP","+","phosphate","+","urea","(","in",")"),4338165). assertion_content_comment('oboGo_UridineDiphosphataseactivity',s("Catalysis","of","the","reaction",":","UDP","+","H2O","=","UMP","+","phosphate","."),4299939). assertion_content_comment('oboGo_UridineRichcytoplasmicpolyadenylylationelementbinding',s("Interacting","selectively","and","non-covalently","with","U-rich","sequence","in","the","3","'","-end","of","nuclear-transcribed","mRNAs",";","required","for","cytoplasmic","polyadenylylation","."),4257971). assertion_content_comment('oboGo_UroporphyrinIiicMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","2","S-adenosyl-L-methionine","+","uroporphyrin","III","=","2","S-adenosyl-L-homocysteine","+","precorrin-2","."),4199376). assertion_content_comment('oboGo_UroporphyrinogenIiisynthaseactivity',s("Catalysis","of","the","reaction",":","hydroxymethylbilane","=","H","(","2",")","O","+","uroporphyrinogen","III","."),4199357). assertion_content_comment('oboGo_UTPActivatednucleotidereceptoractivity',s("Combining","with","a","nucleotide","and","transmitting","the","signal","to","a","heterotrimeric","G-protein","complex","to","initiate","a","change","in","cell","activity",",","activated","by","UTP","."),4300907). assertion_content_comment('oboGo_UTP_Arabinose_1_PhosphateUridylyltransferaseActivity',s("Catalysis","of","the","reaction",":","alpha-L-arabinose","1-phosphate","+","UTP","=","UDP-L-arabinose","+","diphosphate","."),4332743). assertion_content_comment('oboGo_UTPCcomplex',s("A","protein","complex","that","forms","a","subcomplex","of","the","90S","preribosome",".","In","S",".","cerevisiae",",","it","is","composed","of","Rrp7p",",","Utp22p",",","Ckb1p",",","Cka1p",",","Ckb2p","and","Cka2p","."),4075020). assertion_content_comment('oboGo_UTP_Galactose_1_PhosphateUridylyltransferaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-galactose","1-phosphate","+","UTP","=","diphosphate","+","UDP-D-galactose","."),4267635). assertion_content_comment('oboGo_UTP_Glucose_1_PhosphateUridylyltransferaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-glucose","1-phosphate","+","UTP","=","diphosphate","+","UDP-D-glucose","."),4187211). assertion_content_comment('oboGo_UTP_Glucose_1_PhosphateUridylyltransferaseRegulatorActivity',s("Modulates","the","activity","of","UTP",":","glucose-1-phosphate","uridylyltransferase","."),4326105). assertion_content_comment('oboGo_UTP_Monosaccharide_1_PhosphateUridylyltransferaseActivity',s("Catalysis","of","the","reaction",":","UTP","+","a","monosaccharide","1-phosphate","=","diphosphate","+","UDP-monosaccharide","."),4187204). assertion_content_comment('oboGo_UTP_Xylose_1_PhosphateUridylyltransferaseActivity',s("Catalysis","of","the","reaction",":","alpha-D-xylose","1-phosphate","+","UTP","=","UDP-D-xylose","+","diphosphate","."),4368372). assertion_content_comment('oboGo_UUACodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UUA","codon","."),4340170). assertion_content_comment('oboGo_UUCCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UUC","codon","."),4339800). assertion_content_comment('oboGo_UUGCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UUG","codon","."),4340182). assertion_content_comment('oboGo_UUUCodonAminoacidadaptoractivity',s("A","triplet","codon-amino","acid","adaptor","activity","that","recognizes","a","UUU","codon","."),4339788). assertion_content_comment('oboGo_UVAbluelightphototransduction',s("The","sequence","of","reactions","within","a","cell","required","to","convert","absorbed","photons","from","UV-A","or","blue","light","into","a","molecular","signal",";","the","UV-A",",","blue","light","range","is","defined","as","having","a","wavelength","within","the","range","of","approximately","400-500","nm","."),4261666). assertion_content_comment('oboGo_UVDamageexcisionrepair',s("A","DNA","repair","process","that","is","initiated","by","an","endonuclease","that","introduces","a","single-strand","incision","immediately","5","'","of","a","UV-induced","damage","site",".","UV-damage","excision","repair","acts","on","both","cyclobutane","pyrimidine","dimers","(","CPDs",")","and","pyrimidine-pyrimidone","6-4","photoproducts","(","6-4PPs",")"),4178266). assertion_content_comment('oboGo_UVSensitiveopsin',s("OBSOLETE",".","An","opsin","with","maximal","absorption","below","400","nm","."),4297122). assertion_content_comment('oboGo_VacuolarHydrogenTransportingatpase',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4346251). assertion_content_comment('oboGo_VacuolarProtonTransportingvTypeatpasecomplexassembly',s("The","aggregation",",","arrangement","and","bonding","together","of","a","vacuolar","proton-transporting","V-type","ATPase","complex",",","proton-transporting","two-sector","ATPase","complex","that","couples","ATP","hydrolysis","to","the","transport","of","protons","across","the","vacuolar","membrane","."),4180154). assertion_content_comment('oboGo_VacuolarProtonTransportingvTypeatpasecomplex',s("A","proton-transporting","two-sector","ATPase","complex","found","in","the","vacuolar","membrane",",","where","it","acts","as","a","proton","pump","to","mediate","acidification","of","the","vacuolar","lumen","."),3973331). assertion_content_comment('oboGo_VacuolarProtonTransportingvTypeatpasev0domain',s("The","V0","domain","of","a","proton-transporting","V-type","ATPase","found","in","the","vacuolar","membrane","."),3973473). assertion_content_comment('oboGo_VacuolarProtonTransportingvTypeatpasev1domain',s("The","V1","domain","of","a","proton-transporting","V-type","ATPase","found","in","the","vacuolar","membrane","."),3973344). assertion_content_comment('oboGo_VacuoleFusionNonAutophagic',s("The","fusion","of","two","vacuole","membranes","to","form","a","single","vacuole","."),4064602). assertion_content_comment('oboGo_Valine_3_Methyl_2_OxovalerateTransaminaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-methyl-2-oxopentanoate","+","L-valine","=","3-methyl-2-oxobutanoate","+","L-isoleucine","."),4369182). assertion_content_comment('oboGo_ValinePyruvatetransaminaseactivity',s("Catalysis","of","the","reaction",":","L-valine","+","pyruvate","=","3-methyl-2-oxobutanoate","+","L-alanine","."),4257040). assertion_content_comment('oboGo_ValineTrnaligaseactivity',s("Catalysis","of","the","reaction",":","L-valine","+","ATP","+","tRNA","(","Val",")","=","L-valyl-tRNA","(","Val",")","+","AMP","+","diphosphate","+","2","H","(","+",")"),4199699). assertion_content_comment('oboGo_ValylTrnaaminoacylation',s("The","process","of","coupling","valine","to","valyl-tRNA",",","catalyzed","by","valyl-tRNA","synthetase",".","In","tRNA","aminoacylation",",","the","amino","acid","is","first","activated","by","linkage","to","AMP","and","then","transferred","to","either","the","2","'","-","or","the","3","'","-hydroxyl","group","of","the","3","'","-adenosine","residue","of","the","tRNA","."),4179241). assertion_content_comment('oboGo_VAMP4_Syntaxin_6_Syntaxin_16_Vti1aComplex',s("A","SNARE","complex","that","contains","VAMP4",",","syntaxin","6",",","syntaxin","16",",","and","Vti1a","(","or","orthologs","thereof",")"),4180091). assertion_content_comment('oboGo_VanadiumIncorporationIntoMetalloSulfurcluster',s("The","incorporation","of","vanadium","a","metallo-sulfur","cluster","such","as","VFe","(","7-8",")","S","(","n",")"),4306396). assertion_content_comment('oboGo_VanadiumIronnitrogenaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","8","reduced","ferredoxin","+","8","H","+","+","nitrogen","+","16","ATP","=","8","oxidized","ferredoxin","+","2","NH3","+","16","ADP","+","16","phosphate","."),4301447). assertion_content_comment('oboGo_VanadiumIronnitrogenasecomplex',s("An","enzyme","complex","containing","a","vanadium-iron","cluster","found","in","some","species",",","such","as","Azotobacter","vinelandii",".","It","is","composed","of","two","proteins",",","dinitrogenase","and","nitrogenase","reductase",";","dinitrogenase",",","the","vanadium-iron","protein",",","is","tetrameric","with","an","alpha2-beta2","structure",",","and","nitrogenase","reductase","is","a","homodimer","."),4301443). assertion_content_comment('oboGo_VanillateODemethylaseanaerobicactivity',s("Catalysis","of","the","reaction",":","vanillate","+","Co","+","=","Co3","+","-CH3","+","3",",","4-dihydroxybenzoate","."),4277071). assertion_content_comment('oboGo_VanillylAlcoholoxidaseactivity',s("Catalysis","of","the","reaction",":","O","(","2",")","+","vanillyl","alcohol","=","H","(","2",")","O","(","2",")","+","vanillin","."),4277424). assertion_content_comment('oboGo_VasodilationByNorepinephrineEpinephrineinvolvedinregulationofsystemicarterialbloodpressure',s("A","process","that","results","in","an","increase","in","the","diameter","of","an","artery","during","the","norepinephrine-epinephrine","response","to","blood","pressure","change","."),3991082). assertion_content_comment('oboGo_VasopressinLikereceptoractivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4383523). assertion_content_comment('oboGo_VentricularZoneCellProducingasymmetricradialglialcelldivisioninforebrain',s("The","unequal","mitotic","division","of","a","forebrain","radial","glial","cell","that","gives","rise","to","a","radial","glial","cell","and","a","ventricular","zone","cell","."),4047274). assertion_content_comment('oboGo_VeryLong_Chain_3_Hydroxyacyl_CoADehydrogenaseActivity',s("Catalysis","of","the","reaction",":","(","S",")","-3-hydroxyacyl-CoA","+","NAD","(","P",")","+","=","3-oxoacyl-CoA","+","NAD","(","P",")","H","+","H","+",",","where","the","acyl","group","is","a","very","long-chain","fatty","acid","residue",".","Very-long-chain","fatty","acids","have","a","chain","length","of","greater","than","18","carbons","."),4382921). assertion_content_comment('oboGo_VeryLongChainAcylCoadehydrogenaseactivity',s("Catalysis","of","the","reaction",":","acyl-CoA","+","acceptor","=","2",",","3-dehydroacyl-CoA","+","reduced","acceptor",",","where","the","acyl","group","is","a","very","long-chain","fatty","acid","residue","."),4267706). assertion_content_comment('oboGo_VeryLongChainfattyacidbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","fatty","acids","with","a","chain","length","of","C18","or","greater","."),4317234). assertion_content_comment('oboGo_VeryLongChainfattyacidcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","fatty","acids","with","a","chain","length","of","C18","or","greater","."),4317250). assertion_content_comment('oboGo_VeryLongChainfattyacidCoaligaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","a","very-long-chain","carboxylic","acid","+","CoA","=","AMP","+","diphosphate","+","an","acyl-CoA",";","very-long-chain","fatty","acids","have","chain","lengths","of","greater","than","C18","."),4320450). assertion_content_comment('oboGo_VeryLongChainfattyacidmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","fatty","acids","with","a","chain","length","of","C18","or","greater","."),4045826). assertion_content_comment('oboGo_VeryLowDensitylipoproteinparticleassembly',s("The","aggregation","and","arrangement","of","proteins","and","lipids","in","the","liver","to","form","a","very-low-density","lipoprotein","particle","."),4355638). assertion_content_comment('oboGo_VeryLowDensitylipoproteinparticlebinding',s("Interacting","selectively","and","non-covalently","with","a","low-density","lipoprotein","particle",",","a","triglyceride-rich","lipoprotein","particle","that","is","typically","composed","of","APOB100",",","APOE","and","APOCs","and","has","a","density","of","about","1.006","g/ml","and","a","diameter","of","between","20-80","nm","."),4311739). assertion_content_comment('oboGo_VeryLowDensitylipoproteinparticleclearance',s("The","process","in","which","a","very-low-density","lipoprotein","particle","is","removed","from","the","blood","via","receptor-mediated","endocytosis","and","its","constituent","parts","degraded","."),4038368). assertion_content_comment('oboGo_VeryLowDensitylipoproteinparticlereceptoractivity',s("Combining","with","a","very-low-density","lipoprotein","particle","to","initiate","a","change","in","cell","activity","."),4311743). assertion_content_comment('oboGo_VeryLowDensitylipoproteinparticlereceptorbinding',s("Interacting","selectively","and","non-covalently","with","a","very-low-density","lipoprotein","receptor","."),4173016). assertion_content_comment('oboGo_VeryLowDensitylipoproteinparticleremodeling',s("The","acquisition",",","loss","or","modification","of","a","protein","or","lipid","within","a","very-low-density","lipoprotein","particle",",","including","the","hydrolysis","of","triglyceride","by","hepatic","lipase","or","lipoprotein","lipase","and","the","subsequent","loss","of","free","fatty","acid","."),4038044). assertion_content_comment('oboGo_VeryLowDensitylipoproteinparticle',s("A","triglyceride-rich","lipoprotein","particle","that","is","typically","composed","of","APOB100",",","APOE","and","APOCs","and","has","a","density","of","about","1.006","g/ml","and","a","diameter","of","between","20-80","nm",".","It","is","found","in","blood","and","transports","endogenous","products","(","newly","synthesized","cholesterol","and","triglycerides",")","from","the","liver","."),4355902). assertion_content_comment('oboGo_VeryLowDensitylipoprotein',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4216159). assertion_content_comment('oboGo_VesicleFusingatpaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","ATP","+","H2O","=","ADP","+","phosphate",".","The","hydrolysis","of","ATP","by","an","AAA-ATPase",",","involved","in","the","heterotypic","fusion","of","membrane","vesicles","with","target","membranes","and","the","homotypic","fusion","of","various","membrane","compartments","."),4252557). assertion_content_comment('oboGo_VesicleFusion_5',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4219301). assertion_content_comment('oboGo_VesicleMediatedcholesteroltransport',s("The","directed","movement","of","cholesterol",",","cholest-5-en-3-beta-ol",",","or","cholesterol-containing","compounds",",","by","membrane-bounded","vesicles","."),4149017). assertion_content_comment('oboGo_VesicleMediatedtransportinvolvedinfloralorganabscission',s("The","directed","movement","of","substances","within","a","cell","by","a","cellular","process","that","begins","with","the","formation","of","membrane-bounded","vesicles","in","which","the","transported","substances","are","enclosed","or","located","in","the","vesicle","membrane","which","are","then","targeted","to",",","and","fuse","with",",","an","acceptor","membrane","contributing","to","the","shedding","of","a","floral","organ","."),4113907). assertion_content_comment('oboGo_VesicleMediatedtransport',s("A","cellular","transport","process","in","which","transported","substances","are","moved","in","membrane-bounded","vesicles",";","transported","substances","are","enclosed","in","the","vesicle","lumen","or","located","in","the","vesicle","membrane",".","The","process","begins","with","a","step","that","directs","a","substance","to","the","forming","vesicle",",","and","includes","vesicle","budding","and","coating",".","Vesicles","are","then","targeted","to",",","and","fuse","with",",","an","acceptor","membrane","."),3986713). assertion_content_comment('oboGo_VesicleTargeting_5',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4219313). assertion_content_comment('oboGo_VesicleTargetingCisGolgitorougher',s("The","process","in","which","vesicles","are","directed","to","specific","destination","membranes","during","transport","from","the","cis-Golgi","to","the","rough","ER","."),4025408). assertion_content_comment('oboGo_VesicleTargetingInterGolgicisterna',s("The","process","in","which","vesicles","are","directed","to","specific","destination","membranes","during","transport","from","one","Golgi","cisterna","to","another","."),4025451). assertion_content_comment('oboGo_VesicleTargetingRoughERToCisGolgi',s("The","process","in","which","vesicles","are","directed","to","specific","destination","membranes","during","transport","from","the","rough","endoplasmic","reticulum","to","the","cis-Golgi","."),4004930). assertion_content_comment('oboGo_VesicleTargetingTransGolgitoendosome',s("The","process","in","which","vesicles","are","directed","to","specific","destination","membranes","during","transport","from","the","trans-Golgi","to","the","endosome","."),4025303). assertion_content_comment('oboGo_VesicleTransport_5',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4232315). assertion_content_comment('oboGo_VicianinBetaGlucosidaseactivity',s("Catalysis","of","the","reaction",":","(","R",")","-vicianin","+","H","(","2",")","O","=","mandelonitrile","+","vicianose","."),4265362). assertion_content_comment('oboGo_VinylacetylCoadeltaIsomeraseactivity',s("Catalysis","of","the","reaction",":","vinylacetyl-CoA","=","crotonoyl-CoA","."),4265348). assertion_content_comment('oboGo_ViolaxanthinDeEpoxidaseactivity',s("Catalysis","of","the","reaction",":","violaxanthin","+","2","ascorbate","=","zeaxanthin","+","2","dehydroascorbate","+","2","H2O",";","and","antheraxanthin","+","ascorbate","=","zeaxanthin","+","dehydroascorbate","+","H2O","."),4351280). assertion_content_comment('oboGo_VioletSensitiveopsin',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4297154). assertion_content_comment('oboGo_ViralCapsidReEnvelopment',s("The","process","in","which","a","capsid","acquires","another","membrane","envelope",",","subsequent","to","acquiring","an","initial","membrane","envelope","."),4099287). assertion_content_comment('oboGo_ViralCellfusionmoleculeactivity',s("OBSOLETE","(","was","not","defined","before","being","made","obsolete",")"),4236958). assertion_content_comment('oboGo_ViralInducedprematuresenescence',s("A","cellular","senescence","process","associated","with","the","dismantling","of","a","cell","as","a","response","to","viral","infection","."),4155151). assertion_content_comment('oboGo_ViralRNADirectedrnapolymerasecomplex',s("A","virus-specific","protein","complex","that","possesses","RNA-dependent","RNA","polymerase","activity","and","replicates","the","genome","of","an","RNA","virus","."),4319840). assertion_content_comment('oboGo_VirusBuddingFromERMembraneByViralCapsidReEnvelopment',s("The","re-envelopment","of","a","virus",",","in","which","the","nucleocapsid","evaginates","from","the","host","endoplasmic","reticulum","membrane","system",",","thus","acquiring","an","additional","membrane","envelope","."),4356732). assertion_content_comment('oboGo_VirusBuddingFromGolgiMembraneByViralCapsidReEnvelopment',s("The","re-envelopment","of","a","virus",",","in","which","the","nucleocapsid","evaginates","from","the","host","Golgi","membrane","system",",","thus","acquiring","an","additional","membrane","envelope","."),4356746). assertion_content_comment('oboGo_VirusBuddingFromInnerNuclearMembraneByViralCapsidReEnvelopment',s("The","re-envelopment","of","a","virus",",","in","which","the","nucleocapsid","evaginates","from","the","host","inner","nuclear","membrane","system",",","thus","acquiring","an","additional","membrane","envelope","."),4355392). assertion_content_comment('oboGo_VirusBuddingFromNuclearMembraneByViralCapsidReEnvelopment',s("The","re-envelopment","of","a","virus",",","in","which","the","nucleocapsid","evaginates","from","the","host","nuclear","membrane","system",",","thus","acquiring","an","additional","membrane","envelope","."),4355180). assertion_content_comment('oboGo_VirusBuddingFromOuterNuclearMembraneByViralCapsidReEnvelopment',s("The","re-envelopment","of","a","virus",",","in","which","the","nucleocapsid","evaginates","from","the","host","outer","nuclear","membrane","system",",","thus","acquiring","an","additional","membrane","envelope","."),4355185). assertion_content_comment('oboGo_VirusBuddingFromPlasmaMembraneByViralCapsidReEnvelopment',s("The","re-envelopment","of","a","virus",",","in","which","the","nucleocapsid","evaginates","from","the","host","plasma","membrane","system",",","thus","acquiring","an","additional","membrane","envelope","."),4355380). assertion_content_comment('oboGo_VirusHostinteraction',s("Interactions",",","directly","with","the","host","cell","macromolecular","machinery",",","to","allow","virus","replication","."),4045613). assertion_content_comment('oboGo_VirusInfectedcellapoptosis',s("The","process","of","apoptosis","in","cells","infected","with","a","virus","."),4108113). assertion_content_comment('oboGo_VisceralMesodermEndoderminteractioninvolvedinmidgutdevelopment',s("The","process","of","cell-cell","signaling","between","visceral","mesoderm","cells","and","endoderm","cells","that","is","involved","in","the","differentiation","of","cells","in","the","midgut","."),4018282). assertion_content_comment('oboGo_VitaminD24Hydroxylaseactivity',s("Catalysis","of","the","hydroxylation","of","C-24","of","any","form","of","vitamin","D","."),4175115). assertion_content_comment('oboGo_VitaminD25Hydroxylaseactivity',s("Catalysis","of","the","hydroxylation","of","C-25","of","any","form","of","vitamin","D","."),4176766). assertion_content_comment('oboGo_VitaminD325Hydroxylaseactivity',s("Catalysis","of","the","reaction",":","vitamin","D3","+","NADPH","+","H","+","+","O2","=","calcidiol","+","NADP","+","+","H2O","."),4309642). assertion_content_comment('oboGo_VitaminKEpoxidereductasewarfarinInsensitiveactivity',s("Catalysis","of","the","reaction",":","3-hydroxy-2-methyl-3-phytyl-2",",","3-dihydronaphthoquinone","+","oxidized","dithiothreitol","+","H2O","=","2",",","3-epoxy-2",",","3-dihydro-2-methyl-3-phytyl-1",",","4-naphthoquinone","+","1",",","4-dithiothreitol","."),4364811). assertion_content_comment('oboGo_VitaminKEpoxidereductasewarfarinSensitiveactivity',s("Catalysis","of","the","reaction",":","2-methyl-3-phytyl-1",",","4-naphthoquinone","+","oxidized","dithiothreitol","+","H2O","=","2",",","3-epoxy-2",",","3-dihydro-2-methyl-3-phytyl-1",",","4-naphthoquinone","+","1",",","4-dithiothreitol","."),4364822). assertion_content_comment('oboGo_VitellineMembraneFormationInvolvedInChorionContainingeggshellformation',s("Construction","of","the","vitelline","membrane","portion","of","a","chorion-containing","eggshell",".","An","example","of","this","is","found","in","Drosophila","melanogaster","."),4018743). assertion_content_comment('oboGo_Vitexin2ORhamnoside7OMethyltransferaseactivity',s("Catalysis","of","the","reaction",":","S-adenosyl-L-methionine","+","vitexin","2","'","'","-O-beta-L-rhamnoside","=","S-adenosyl-L-homocysteine","+","7-O-methylvitexin","2","'","'","-O-beta-L-rhamnoside","."),4342901). assertion_content_comment('oboGo_VitexinBetaGlucosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-D-glucose","+","vitexin","=","H","(","+",")","+","UDP","+","vitexin","2","'","'","-O-beta-D-glucoside","."),4265320). assertion_content_comment('oboGo_VoltageGatedanionchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","an","anion","by","a","voltage-gated","channel",".","An","anion","is","a","negatively","charged","ion",".","A","voltage-gated","channel","is","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4218038). assertion_content_comment('oboGo_VoltageGatedanionchannelporinactivity',"OBSOLETE.",4292547). assertion_content_comment('oboGo_VoltageGatedcalciumchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","calcium","ion","by","a","voltage-gated","channel",".","A","voltage-gated","channel","is","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4218000). assertion_content_comment('oboGo_VoltageGatedcalciumchannelcomplexassembly',s("Cellular","protein","complex","assembly","that","results","in","the","formation","of","a","voltage-gated","calcium","channel","complex","."),4177690). assertion_content_comment('oboGo_VoltageGatedcalciumchannelcomplex',s("A","protein","complex","that","forms","a","transmembrane","channel","through","which","calcium","ions","may","pass","in","response","to","changes","in","membrane","potential","."),4221496). assertion_content_comment('oboGo_VoltageGatedcationchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","cation","by","a","voltage-gated","channel",".","A","cation","is","a","positively","charged","ion",".","A","voltage-gated","channel","is","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4217874). assertion_content_comment('oboGo_VoltageGatedchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","solute","by","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4217867). assertion_content_comment('oboGo_VoltageGatedchloridechannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","chloride","ion","by","a","voltage-gated","channel",".","A","voltage-gated","channel","is","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4218042). assertion_content_comment('oboGo_VoltageGatedionchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","an","ion","by","a","voltage-gated","channel",".","An","ion","is","an","atom","or","group","of","atoms","carrying","an","electric","charge","by","virtue","of","having","gained","or","lost","one","or","more","electrons",".","A","voltage-gated","channel","is","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4217869). assertion_content_comment('oboGo_VoltageGatedpotassiumchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","potassium","ion","by","a","voltage-gated","channel",".","A","voltage-gated","channel","is","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4217876). assertion_content_comment('oboGo_VoltageGatedprotonchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","proton","by","a","voltage-gated","channel",".","A","voltage-gated","channel","is","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4311210). assertion_content_comment('oboGo_VoltageGatedsodiumchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","sodium","ion","by","a","voltage-gated","channel",".","A","voltage-gated","channel","is","a","channel","whose","open","state","is","dependent","on","the","voltage","across","the","membrane","in","which","it","is","embedded","."),4218054). assertion_content_comment('oboGo_VoltageGatedsodiumchannelcomplex',s("A","sodium","channel","in","a","cell","membrane","whose","opening","is","governed","by","the","membrane","potential","."),3981974). assertion_content_comment('oboGo_VoltageGatedsulfateantiporteractivity',s("Catalysis","of","the","transfer","of","a","solute","or","solutes","from","one","side","of","a","membrane","to","the","other","according","to","the","reaction",":","sulfate","(","out",")","+","solute","(","in",")","=","solute","(","in",")","+","sulfate","(","out",")",",","by","a","channel","in","a","cell","membrane","whose","opening","is","governed","by","the","membrane","potential","."),4359944). assertion_content_comment('oboGo_VolumeSensitiveanionchannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","an","anion","by","a","volume-sensitive","channel",".","An","anion","is","a","negatively","charged","ion",".","A","volume-sensitive","channel","is","a","channel","that","responds","to","changes","in","the","volume","of","a","cell","."),4158680). assertion_content_comment('oboGo_VolumeSensitivechloridechannelactivity',s("Catalysis","of","the","transmembrane","transfer","of","a","chloride","ion","by","a","volume-sensitive","channel",".","A","volume-sensitive","channel","is","a","channel","that","responds","to","changes","in","the","volume","of","a","cell","."),4158694). assertion_content_comment('oboGo_Vomifoliol4Dehydrogenaseactivity',s("Catalysis","of","the","reaction",":","(","6S",",","9R",")","-6-hydroxy-3-oxo-alpha-ionol","+","NAD","(","+",")","=","(","6S",")","-6-hydroxy-3-oxo-alpha-ionone","+","H","(","+",")","+","NADH","."),4265310). assertion_content_comment('oboGo_WataseniaLuciferin2Monooxygenaseactivity',s("Catalysis","of","the","reaction",":","Watasenia","luciferin","+","O2","=","oxidized","Watasenia","luciferin","+","CO2","+","light","."),4265297). assertion_content_comment('oboGo_WaterSolublevitaminbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","any","of","a","diverse","group","of","vitamins","that","are","soluble","in","water","."),4046102). assertion_content_comment('oboGo_WaterSolublevitamincatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","any","of","a","diverse","group","of","vitamins","that","are","soluble","in","water","."),4229139). assertion_content_comment('oboGo_WaterSolublevitaminmetabolicprocess',s("The","chemical","reactions","and","pathways","involving","any","of","a","diverse","group","of","vitamins","that","are","soluble","in","water","."),4046064). assertion_content_comment('oboGo_WaxEsterhydrolaseactivity',s("Catalysis","of","the","reaction",":","a","wax","ester","+","H2O","=","a","long-chain","alcohol","+","a","long-chain","carboxylate","."),4265110). assertion_content_comment('oboGo_WD40Repeatdomainbinding',s("Interacting","selectively","and","non-covalently","with","a","WD40","repeat","domain","of","a","protein",".","The","WD40","repeat","is","a","short","structural","motif","of","approximately","40","amino","acids",",","often","terminating","in","a","tryptophan-aspartic","acid","(","W-D",")","dipeptide",".","Several","of","these","repeats","are","combined","to","form","a","type","of","protein","domain","called","the","WD","domain","."),4168849). assertion_content_comment('oboGo_WeibelPaladebody',s("A","large",",","elongated",",","rod-shaped","secretory","granule","characteristic","of","vascular","endothelial","cells","that","contain","a","number","of","structurally","and","functionally","distinct","proteins",",","of","which","the","best","characterized","are","von","Willebrand","factor","(","VWF",")","and","P-selectin",".","Weibel-Palade","bodies","are","formed","from","the","trans-Golgi","network","in","a","process","that","depends","on","VWF",",","which","is","densely","packed","in","a","highly","organized","manner",",","and","on","coat","proteins","that","remain","associated","with","the","granules",".","Upon","cell","stimulation",",","regulated","exocytosis","releases","the","contained","proteins","to","the","cell","surface",",","where","they","act","in","the","recruitment","of","platelets","and","leukocytes","and","in","inflammatory","and","vasoactive","responses","."),4347445). assertion_content_comment('oboGo_WideSpectrumproteaseinhibitoractivity',s("OBSOLETE",".","Stops",",","prevents","or","reduces","the","activity","of","a","protease","by","a","wide-spectrum","protease","inhibitor",".","A","wide-spectrum","protease","inhibitor","is","a","protein","having","a","peptide","stretch","which","contains","specific","cleavage","sites","for","different","proteinases","enabling","inhibition","of","all","four","classes","of","proteinases","by","formation","of","a","covalent","bond","between","the","inhibitor","and","the","protease","."),4267439). assertion_content_comment('oboGo_WMolybdopterincofactorbiosyntheticprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","formation","of","the","W-molybdopterin","cofactor",",","essential","for","the","catalytic","activity","of","some","enzymes",".","The","cofactor","consists","of","a","mononuclear","tungsten","ion","(","W",")","coordinated","by","one","or","two","molybdopterin","ligands","."),4306380). assertion_content_comment('oboGo_WMolybdopterincofactorcatabolicprocess',s("The","chemical","reactions","and","pathways","resulting","in","the","breakdown","of","the","W-molybdopterin","cofactor",",","essential","for","the","catalytic","activity","of","some","enzymes",".","The","cofactor","consists","of","a","mononuclear","tungsten","ion","(","W",")","coordinated","by","one","or","two","molybdopterin","ligands","."),4333781). assertion_content_comment('oboGo_WMolybdopterincofactormetabolicprocess',s("The","chemical","reactions","and","pathways","involving","the","W-molybdopterin","cofactor",",","essential","for","the","catalytic","activity","of","some","enzymes",".","The","cofactor","consists","of","a","mononuclear","tungsten","ion","(","W",")","coordinated","by","one","or","two","molybdopterin","ligands","."),4306365). assertion_content_comment('oboGo_WntProteinbinding',s("Interacting","selectively","and","non-covalently","with","Wnt-protein",",","a","secreted","growth","factor","involved","in","signaling","."),4258059). assertion_content_comment('oboGo_X11Likeproteinbinding',s("Interacting","selectively","and","non-covalently","with","X11-like","protein",",","a","neuron-specific","adaptor","protein","."),4316057). assertion_content_comment('oboGo_XenobioticTransportingatpaseactivity',s("Catalysis","of","the","reaction",":","ATP","+","H2O","+","xenobiotic","(","in",")","=","ADP","+","phosphate","+","xenobiotic","(","out",")"),4252729). assertion_content_comment('oboGo_XHisdipeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","Xaa-His","dipeptides","."),4251605). assertion_content_comment('oboGo_XOpioidreceptoractivity',s("Combining","with","an","opioid","to","initiate","a","change","in","cell","activity",",","with","the","pharmacological","characteristics","of","X-opioid","receptors","."),4297243). assertion_content_comment('oboGo_XProaminopeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","release","of","any","N-terminal","amino","acid",",","including","proline",",","that","is","linked","with","proline",",","even","from","a","dipeptide","or","tripeptide","."),4253988). assertion_content_comment('oboGo_XProdipeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","Xaa-Pro","dipeptides",";","also","acts","on","aminoacyl-hydroxyproline","analogs",".","No","action","on","Pro-Pro","."),4210329). assertion_content_comment('oboGo_XProdipeptidylPeptidaseactivity',s("OBSOLETE",".","Catalysis","of","the","hydrolysis","of","the","terminal","bond","of","Xaa-Pro-Xaa","motifs","to","release","unblocked",",","N-terminal","dipeptides","from","substrates","including","Ala-Pro-para-nitroanilide","and","(","sequentially",",","at","the","second",",","fourth","and","sixth","bonds",")","of","the","motif","Tyr-Pro-Phe-Pro-Gly-Pro-Ile","."),4269210). assertion_content_comment('oboGo_XRCC2Rad51dcomplex',s("A","heterodimeric","DNA","recombinase","mediator","complex","that","contains","the","Rad51","paralogs","RAD51D","and","XRCC2",",","or","orthologs","thereof",";","conserved","from","fission","yeast","to","human","but","absent","from","budding","yeast","."),4347359). assertion_content_comment('oboGo_Xylan13BetaXylosidaseactivity',s("Catalysis","of","the","hydrolysis","of","successive","xylose","residues","from","the","non-reducing","termini","of","1",",","3-beta-D-xylans","."),4344303). assertion_content_comment('oboGo_Xylan14BetaXylosidaseactivity',s("Catalysis","of","the","hydrolysis","of","1",",","4-beta-D-xylans","so","as","to","remove","successive","D-xylose","residues","from","the","non-reducing","termini","."),4256997). assertion_content_comment('oboGo_XylanAlpha_12_GlucuronosidaseActivity',s("Catalysis","of","the","hydrolysis","of","alpha-D-1",",","2-","(","4-O-methyl",")","glucuronosyl","links","in","the","main","chain","of","hardwood","xylans","."),4344856). assertion_content_comment('oboGo_XylanEndo_13_Beta_XylosidaseActivity',s("Catalysis","of","the","random","hydrolysis","of","1",",","3-beta-D-glycosidic","linkages","in","1",",","3-beta-D-xylans","."),4344193). assertion_content_comment('oboGo_Xyloglucan16AlphaXylosidaseactivity',s("Catalysis","of","the","hydrolysis","of","xyloglucan","side","chains","so","as","to","remove","unsubstituted","D-xylose","residues","attached","to","the","glucose","located","at","the","non-reducing","terminus","."),4181395). assertion_content_comment('oboGo_Xyloglucan4Glucosyltransferaseactivity',s("Catalysis","of","the","transfer","of","a","beta-D-glucosyl","residue","from","UDP-glucose","on","to","a","glucose","residue","in","xyloglucan",",","forming","a","beta-1",",","4-D-glucosyl-D-glucose","linkage","."),4343160). assertion_content_comment('oboGo_Xyloglucan6Xylosyltransferaseactivity',s("Catalysis","of","the","transfer","of","an","alpha-D-xylosyl","residue","from","UDP-D-xylose","to","a","glucose","residue","in","xyloglucan",",","forming","an","alpha-1",",","6-D-xylosyl-D-glucose","linkage","."),4343907). assertion_content_comment('oboGo_Xyloglucan_SpecificEndo_Beta_14_GlucanaseActivity',s("Catalysis","of","the","reaction",":","xyloglucan","+","H2O","=","xyloglucan","oligosaccharides",".","This","reaction","is","the","endohydrolysis","of","1",",","4-beta-D-glucosidic","linkages","in","xyloglucan","."),4344365). assertion_content_comment('oboGo_Xyloglucan_SpecificExo_Beta_14_GlucanaseActivity',s("Catalysis","of","the","reaction",":","xyloglucan","+","H2O","=","xyloglucan","oligosaccharides",".","This","reaction","is","the","exohydrolysis","of","1",",","4-beta-D-glucosidic","linkages","in","xyloglucan","."),4344456). assertion_content_comment('oboGo_Xylono_14_LactonaseActivity',s("Catalysis","of","the","reaction",":","D-xylono-1",",","4-lactone","+","H2O","=","D-xylonate","."),4267247). assertion_content_comment('oboGo_Xylosylprotein4BetaGalactosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-galactose","+","O-beta-D-xylosylprotein","=","UDP","+","4-beta-D-galactosyl-O-beta-D-xylosylprotein","."),4359144). assertion_content_comment('oboGo_Xylulose5Phosphatemetabolicprocess',s("The","chemical","reactions","and","pathways","involving","xylulose","5-phosphate",",","a","derivative","of","the","ketopentose","xylulose","phosphorylated","at","the","5","carbon",";","it","is","an","intermediate","in","the","pentose","phosphate","pathway","."),4241178). assertion_content_comment('oboGo_YeastFormcellwall',s("The","wall","surrounding","a","cell","of","a","dimorphic","fungus","growing","in","the","single-cell","budding","yeast","form",",","in","contrast","to","the","filamentous","or","hyphal","form","."),4310082). assertion_content_comment('oboGo_YFormdnabinding',s("Interacting","selectively","and","non-covalently","with","segment","of","DNA","shaped","like","a","Y",".","This","shape","occurs","when","DNA","contains","a","region","of","paired","double-stranded","DNA","on","one","end","and","a","region","of","unpaired","DNA","strands","on","the","opposite","end","."),4362810). assertion_content_comment('oboGo_Zeatin9Aminocarboxyethyltransferaseactivity',s("Catalysis","of","the","reaction",":","O-acetyl-L-serine","+","zeatin","=","L-lupinate","+","acetate","+","H","(","+",")"),4267113). assertion_content_comment('oboGo_ZeatinOBetaDXylosyltransferaseactivity',s("Catalysis","of","the","reaction",":","UDP-alpha-D-xylose","+","zeatin","=","O-beta-D-xylosylzeatin","+","H","(","+",")","+","UDP","."),4267303). assertion_content_comment('oboGo_ZFarnesyldiphosphatesynthaseactivity',s("Catalysis","of","the","reaction",":","geranyl","diphosphate","+","isopentenyl","diphosphate","=","2-cis",",","6-trans-farnesyl","diphosphate","+","diphosphate","."),4343840). assertion_content_comment('oboGo_ZfTrafdomainbinding',s("Interacting","selectively","and","non-covalently","with","a","TRAF-type","zinc","finger","domain","of","a","protein","."),4288412). assertion_content_comment('oboGo_ZfTrafdomainMediatedcomplexassembly',s("A","process","of","protein","complex","assembly","in","which","the","arrangement","and","bonding","together","of","the","set","of","components","that","form","the","protein","complex","is","mediated","by","a","TRAF-type","zinc","finger","(","zf-TRAF",")","domain","interaction","."),4172047). assertion_content_comment('oboGo_ZGammaBisabolenesynthaseactivity',s("Catalysis","of","the","reaction",":","2-trans",",","6-trans-farnesyl","diphosphate","=","(","Z",")","-gamma-bisabolene","+","diphosphate","."),4191438). assertion_content_comment('oboGo_ZincCadmiumCobaltNickelLeadEffluxatpaseactivity',s("OBSOLETE",".","Catalysis","of","the","reaction",":","Me2","+","(","in",")","+","ATP","=","Me2","+","(","out",")","+","ADP","+","phosphate",",","where","Me","is","Zn2","+",",","Cd2","+",",","Co2","+",",","Ni2","+","or","Pb2","+"),4252845). 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assertion_content('commentOnTextualInferenceProblem','iCW_PARC_33_TEP',"",1981727). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_34_TEP',"",1981738). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_35_TEP',"",1981749). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_36_TEP',"",1981760). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_37_TEP',"",1981771). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_38_TEP',"",1981782). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_39_TEP',"",1981793). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_3_TEP',"",1981397). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_40_TEP',"",1981804). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_41_TEP',"",1981815). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_42_TEP',"",1981826). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_43_TEP',"",1981837). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_44_TEP',"",1981848). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_45_TEP',"",1981859). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_46_TEP',"",1981870). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_47_TEP',"",1981881). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_48_TEP',"",1981892). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_49_TEP',"",1981903). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_4_TEP',"",1981408). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_50_TEP',"",1981914). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_51_TEP',"",1981925). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_52_TEP',"",1981936). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_53_TEP',"",1981947). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_54_TEP',"",1981958). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_55_TEP',"",1981969). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_56_TEP',"",1981980). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_57_TEP',"",1981991). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_58_TEP',"",1982002). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_59_TEP',"",1982013). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_5_TEP',"",1981419). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_60_TEP',"",1982024). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_61_TEP',"",1982035). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_62_TEP',"",1982046). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_63_TEP',"",1982057). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_64_TEP',"",1982068). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_65_TEP',"",1982079). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_66_TEP',"",1982090). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_67_TEP',"",1982101). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_68_TEP',"",1982112). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_69_TEP',"",1982123). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_6_TEP',"",1981430). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_70_TEP',"",1982134). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_71_TEP',"",1982145). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_72_TEP',"",1982156). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_73_TEP',"",1982167). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_74_TEP',"",1982178). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_75_TEP',"",1982189). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_76_TEP',"",1982200). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_7_TEP',"",1981441). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_8_TEP',"",1981452). assertion_content('commentOnTextualInferenceProblem','iCW_PARC_9_TEP',"",1981463). assertion_content('commentOnTextualInferenceProblem','iCW_St001TEP',"",1988430). assertion_content('commentOnTextualInferenceProblem','iCW_St002TEP',"",1988446). assertion_content('commentOnTextualInferenceProblem','iCW_St003TEP',"",1988462). assertion_content('commentOnTextualInferenceProblem','iCW_St004TEP',"",1988478). assertion_content('commentOnTextualInferenceProblem','iCW_St005TEP',"",1988494). assertion_content('commentOnTextualInferenceProblem','iCW_St006TEP',"",1988510). assertion_content('commentOnTextualInferenceProblem','iCW_St007TEP',"",1988526). assertion_content('commentOnTextualInferenceProblem','iCW_St008TEP',"",1988542). assertion_content('commentOnTextualInferenceProblem','iCW_St009TEP',"",1988558). assertion_content('commentOnTextualInferenceProblem','iCW_St010TEP',"",1988574). assertion_content('commentOnTextualInferenceProblem','iCW_St011TEP',"",1988590). assertion_content('commentOnTextualInferenceProblem','iCW_St012TEP',"",1988606). assertion_content('commentOnTextualInferenceProblem','iCW_St013TEP',"",1988622). assertion_content('commentOnTextualInferenceProblem','iCW_St014TEP',"",1988638). assertion_content('commentOnTextualInferenceProblem','iCW_St015TEP',"",1988654). assertion_content('commentOnTextualInferenceProblem','iCW_St016TEP',"",1988670). assertion_content('commentOnTextualInferenceProblem','iCW_St017TEP',"",1988686). assertion_content('commentOnTextualInferenceProblem','iCW_St018TEP',"",1988702). assertion_content('commentOnTextualInferenceProblem','iCW_St019TEP',"",1988718). assertion_content('commentOnTextualInferenceProblem','iCW_St020TEP',"",1988734). assertion_content('commentOnTextualInferenceProblem','iCW_St021TEP',"",1988750). assertion_content('commentOnTextualInferenceProblem','iCW_St022TEP',"",1988766). assertion_content('commentOnTextualInferenceProblem','iCW_St023TEP',"",1988782). assertion_content('commentOnTextualInferenceProblem','iCW_St024TEP',"",1988798). assertion_content('commentOnTextualInferenceProblem','iCW_St025TEP',"",1988814). assertion_content('commentOnTextualInferenceProblem','iCW_St026TEP',"",1988830). assertion_content('commentOnTextualInferenceProblem','iCW_St027TEP',"",1988846). assertion_content('commentOnTextualInferenceProblem','iCW_St028TEP',"",1988862). assertion_content('commentOnTextualInferenceProblem','iCW_St029TEP',"",1988878). assertion_content('commentOnTextualInferenceProblem','iCW_St030TEP',"",1988894). assertion_content('commentOnTextualInferenceProblem','iLCC_M_10_TEP',"",2035438). assertion_content('commentOnTextualInferenceProblem','iLCC_M_13_TEP',"",2035500). assertion_content('commentOnTextualInferenceProblem','iLCC_M_14_TEP',"",2035562). assertion_content('commentOnTextualInferenceProblem','iLCC_M_17_TEP',"",2035624). assertion_content('commentOnTextualInferenceProblem','iLCC_M_19_TEP',"",2035659). assertion_content('commentOnTextualInferenceProblem','iLCC_M_1_TEP',"",2035190). assertion_content('commentOnTextualInferenceProblem','iLCC_M_22_TEP',"",2035721). assertion_content('commentOnTextualInferenceProblem','iLCC_M_25_TEP',"",2035756). assertion_content('commentOnTextualInferenceProblem','iLCC_M_27_TEP',"",2035899). assertion_content('commentOnTextualInferenceProblem','iLCC_M_28_TEP',"",2036042). assertion_content('commentOnTextualInferenceProblem','iLCC_M_30_TEP',"",2036104). assertion_content('commentOnTextualInferenceProblem','iLCC_M_32_TEP',"",2036301). assertion_content('commentOnTextualInferenceProblem','iLCC_M_33_TEP',"",2036417). assertion_content('commentOnTextualInferenceProblem','iLCC_M_35_TEP',"",2036533). assertion_content('commentOnTextualInferenceProblem','iLCC_M_37_TEP',"",2036606). assertion_content('commentOnTextualInferenceProblem','iLCC_M_39_TEP',"",2036722). assertion_content('commentOnTextualInferenceProblem','iLCC_M_3_TEP',"",2035279). assertion_content('commentOnTextualInferenceProblem','iLCC_M_41_TEP',"",2036811). assertion_content('commentOnTextualInferenceProblem','iLCC_M_43_TEP',"",2036900). assertion_content('commentOnTextualInferenceProblem','iLCC_M_44_TEP',"",2037016). assertion_content('commentOnTextualInferenceProblem','iLCC_M_46_TEP',"",2037105). assertion_content('commentOnTextualInferenceProblem','iLCC_M_49_TEP',"",2037248). assertion_content('commentOnTextualInferenceProblem','iLCC_M_50_TEP',"",2037310). assertion_content('commentOnTextualInferenceProblem','iLCC_M_53_TEP',"",2037372). assertion_content('commentOnTextualInferenceProblem','iLCC_M_55_TEP',"",2037434). assertion_content('commentOnTextualInferenceProblem','iLCC_M_56_TEP',"",2037496). assertion_content('commentOnTextualInferenceProblem','iLCC_M_58_TEP',"",2037516). assertion_content('commentOnTextualInferenceProblem','iLCC_M_60_TEP',"",2037605). assertion_content('commentOnTextualInferenceProblem','iLCC_M_6_TEP',"",2035341). assertion_content('commentOnTextualInferenceProblem','iLCC_M_7_TEP',"",2035376). assertion_content('commentOnTextualInferenceProblem','lcch_0001Tep',"",2032115). assertion_content('commentOnTextualInferenceProblem','lcch_0002Tep',"",2032150). assertion_content('commentOnTextualInferenceProblem','lcch_0003Tep',"",2032185). assertion_content('commentOnTextualInferenceProblem','lcch_0004Tep',"",2032221). assertion_content('commentOnTextualInferenceProblem','lcch_0005Tep',"",2032257). assertion_content('commentOnTextualInferenceProblem','lcch_0006aTep',"",2032293). assertion_content('commentOnTextualInferenceProblem','lcch_0006bTep',"",2032329). assertion_content('commentOnTextualInferenceProblem','lcch_0006cTep',"",2032365). assertion_content('commentOnTextualInferenceProblem','lcch_0007Tep',"",2032400). assertion_content('commentOnTextualInferenceProblem','lcch_0008Tep',"",2032436). assertion_content('commentOnTextualInferenceProblem','lcch_0009Tep',"",2032472). assertion_content('commentOnTextualInferenceProblem','lcch_0010Tep',"",2032507). assertion_content('commentOnTextualInferenceProblem','lcch_0011Tep',"",2032542). assertion_content('commentOnTextualInferenceProblem','lcch_0012Tep',"",2032578). assertion_content('commentOnTextualInferenceProblem','lcch_0013Tep',"",2032614). assertion_content('commentOnTextualInferenceProblem','lcch_0014Tep',"",2032650). assertion_content('commentOnTextualInferenceProblem','lcch_0015Tep',"",2032686). assertion_content('commentOnTextualInferenceProblem','lcch_0016Tep',"",2032722). assertion_content('commentOnTextualInferenceProblem','lcch_0017Tep',"",2032758). assertion_content('commentOnTextualInferenceProblem','lcch_0018Tep',"",2032794). assertion_content('commentOnTextualInferenceProblem','lcch_0019Tep',"",2032830). assertion_content('commentOnTextualInferenceProblem','lcch_0020Tep',"",2032866). assertion_content('commentOnTextualInferenceProblem','lcch_0021Tep',"",2032901). assertion_content('commentOnTextualInferenceProblem','lcch_0022Tep',"",2032937). assertion_content('commentOnTextualInferenceProblem','lcch_0023Tep',"",2032973). assertion_content('commentOnTextualInferenceProblem','lcch_0024Tep',"",2033008). assertion_content('commentOnTextualInferenceProblem','lcch_0025Tep',"",2033044). assertion_content('commentOnTextualInferenceProblem','lcch_0026Tep',"",2033080). assertion_content('commentOnTextualInferenceProblem','lcch_0027Tep',"",2033116). assertion_content('commentOnTextualInferenceProblem','lcch_0028Tep',"",2033151). assertion_content('commentOnTextualInferenceProblem','lcch_0029Tep',"",2033187). assertion_content('commentOnTextualInferenceProblem','lcch_0030Tep',"",2033223). assertion_content('commentOnTextualInferenceProblem','lcch_0031Tep',"",2033259). assertion_content('commentOnTextualInferenceProblem','lcch_0032Tep',"",2033295). assertion_content('commentOnTextualInferenceProblem','lcch_0033Tep',"",2033331). assertion_content('commentOnTextualInferenceProblem','lcch_0034Tep',"",2033367). assertion_content('commentOnTextualInferenceProblem','lcch_0035Tep',"",2033403). assertion_content('commentOnTextualInferenceProblem','lcch_0036Tep',"",2033439). assertion_content_comment('ontologyAugmentsOntology',s("","(","#$","ontologyAugmentsOntology","AUG-ONT","ONT",")","","means","that","","AUG-ONT","","is","an","ontology","that","augments","","ONT",""),3231958). 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assertion_content_comment('patientHasBeenChronicUserOfDrug',s("(","#$","patientHasBeenChronicUserOfDrug","PATIENT","DRUG",")","means","that","PATIENT","has","been","a","chronic","user","of","DRUG","for","some","period","of","time","."),4944662). assertion_content_comment('patientHasBeenChronicUserOfNarcoticAntitussives',s("(","#$","patientHasBeenChronicUserOfNarcoticAntitussives","PATIENT",")","means","that","PATIENT","has","been","a","chronic","user","of","drugs","that","have","some","#$","NarcoticAntitussive","as","an","ingredient","for","a","period","of","180","days","or","more","."),4968814). assertion_content_comment('patientHasBeenChronicUserOfOpioidInjection',s("(","#$","patientHasBeenChronicUserOfOpioidInjection","PATIENT",")","means","that","PATIENT","has","been","a","chronic","user","of","injected","opioid","drugs","for","180","days","or","more","."),4973719). assertion_content_comment('patientHasClaimForGC3WithDosageForm',s("(","#$","patientHasClaimForGC3WithDosageForm","PAT","CLAIM","CODE","DOSAGE-TYPE",")","means","that","PAT","is","a","patient","whith","a","filing","of","a","claim","for","health","insurance","CLAIM","for","a","drug","with","the","GC3","code","CODE","that","has","the","dosage","form","DOSAGE-TYPE","."),4894713). assertion_content_comment('patientHasClaimForPharmaceuticalTypeExceedingDosesPerDay',s("(","#$","patientHasClaimForPharmaceuticalTypeExceedingDosesPerDay","PATIENT","DRUG-TYPE","N",")","means","that","PATIENT","has","at","some","point","filed","a","health","insurance","claim","for","the","#$","PharmacyFormalProductType","DRUG-TYPE","for","more","than","N","doses","per","day",",","without","a","corresponding","ER","pharmaceutical","."),4925212). assertion_content_comment('patientHasClaimOfTypeOnDateForGC3',s("(","#$","patientHasClaimOfTypeOnDateForGC3","PATIENT","CLAIM","CLAIM-TYPE","DATE","CODE",")","means","that","PATIENT","'","s","claim","for","a","narcotic","drug","CLAIM","is","processed","on","DATE","."),4897022). assertion_content_comment('patientHasClaimOnDateForNarcoticWithGC3',s("(","#$","patientHasClaimOfTypeOnDateForGC3","PATIENT","CLAIM","DATE","CODE",")","means","that","PATIENT","'","s","claim","for","a","narcotic","drug","CLAIM","for","a","drug","with","GC3","code","CODE","is","processed","on","DATE","."),4961004). assertion_content_comment('patientHasClaimOnDate',s("(","#$","patientHasClaimOnDate","PATIENT","CLAIM","DATE",")","means","that","PATIENT","'","s","claim","CLAIM","is","processed","on","DATE","."),4895932). assertion_content_comment('patientHasClaimsDispensednarcotic',s("(","#$","patientHasClaims-DispensedNarcotic","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","dispensed","narcotic","claims","made","by","PATIENT","."),4992204). assertion_content_comment('patientHasClaimsDispensednonnarcotic',s("(","#$","patientHasClaims-DispensedNonNarcotic","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","dispensed","non-narcotic","claims","made","by","PATIENT","."),4992331). assertion_content_comment('patientHasClaimsUndispensedernarcotic',s("(","#$","patientHasClaims-UndispensedIRNarcotic","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","undispensed","IR","narcotic","claims","made","by","PATIENT","."),4992363). assertion_content_comment('patientHasClaimsUndispensedirnarcotic',s("(","#$","patientHasClaims-UndispensedIRNarcotic","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","undispensed","IR","narcotic","claims","made","by","PATIENT","."),4992355). assertion_content_comment('patientHasClaimsUndispensednarcotic',s("(","#$","patientHasClaims-UndispensedNarcotic","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","non-dispensed","narcotic","claims","made","by","PATIENT","."),4992339). assertion_content_comment('patientHasClaimsUndispensednonnarcotic',s("(","#$","patientHasClaims-UndispensedNonNarcotic","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","non-dispensed","non-narcotic","claims","made","by","PATIENT","."),4992347). assertion_content_comment('patientHasConditionInHistoryAtOrPriorToEvent',s("(","#$","patientHasConditionInHistoryAtOrPriorToEvent","PATIENT","COND-TYPE","EVENT",")","means","that","at","some","point","prior","to","EVENT",",","patient","PATIENT","had","the","condition","COND-TYPE","."),4895012). assertion_content_comment('patientHasDCForDrugOnDateWithReleaseTypeAndSupply',s("(","#$","patientHasDCForDrugOnDateWithReleaseTypeAndSupply","PATIENT","DRUG","DATE","RELEASE-CLASS","SUPPLY",")","means","that","PATIENT","had","a","dispensed","claim","on","DATE","for","DRUG","(","in","RELEASE_CLASS",")","with","a","days","supply","of","SUPPLY","."),4958337). assertion_content_comment('patientHasDCForDrugOnDateWithSupply',s("(","#$","patientHasDCForDrugOnDateWithSupply","PATIENT","DRUG","DATE","SUPPLY",")","means","that","PATIENT","had","a","dispensed","claim","on","DATE","for","DRUG","with","a","days","supply","of","SUPPLY","."),4958092). assertion_content_comment('patientHasDiagnosesWithNamesSet',s("(","#$","patientHasDiagnosesWithNames-Set","PATIENT","SET",")","means","that","PATIENT","has","been","diagnosed","with","conditions","corresponding","to","the","ICD-9","codes","in","the","set","SET","."),4907036). assertion_content_comment('patientHasDosageRateForHICLInDurationBeforeClaim',s("(","#$","patientHasDosageRateForHICLInDurationBeforeClaim","PATIENT","CLAIM","DURATION","CODE","RATE",")","means","that","int","the","DURATION","time","before","CLAIM",",","PATIENT","was","acquiring","approved","prescription","for","the","drug","associated","with","HICL","code","CODE","at","a","rate","that","would","entail","the","consumption","of","those","drugs","at","RATE","."),4929177). assertion_content_comment('patientHasEarliestAcceptedClaimForHICLPriorToAcceptedClaimForHICLInDuration',s("(","#$","patientHasEarliestAcceptedClaimForHICLPriorToAcceptedClaimForHICLInDuration","PATIENT","CLAIM","CODE","DURATION","EARLY-CLAIM",")","means","that","EARLY-CLAIM","is","the","earliest","accepted","claim","for","PATIENT","for","a","drug","with","the","HICL","code","CODE",",","within","DURATION","before","the","accepted","claim","CLAIM","which","is","also","for","a","drug","with","the","HICL","code","CODE","."),4928902). assertion_content_comment('patientHasEquivalentERNarcoticDoseRateBetweenDates',s("(","#$","patientHasEquivalentERNarcoticDoseRateBetweenDates","PATIENT","DOSE-RATE","DATE1","DATE2",")","means","that","between","DATE1","and","DATE2",",","PATIENT","has","DOSE-RATE","for","extended","release","narcotics",",","where","DOSE-RATE","is","expressed","in","oral-morphine-equivalents","."),4961508). assertion_content_comment('patientHasEquivalentIRNarcoticDoseRateBetweenDates',s("(","#$","patientHasEquivalentIRNarcoticDoseRateBetweenDates","PATIENT","DOSE-RATE","DATE1","DATE2",")","means","that","between","DATE1","and","DATE2",",","PATIENT","has","DOSE-RATE","for","immediate","release","narcotics",",","where","DOSE-RATE","is","expressed","in","oral-morphine-equivalents","."),4961510). assertion_content_comment('patientHasHadIRDoseGreaterThanHalfOfERDose',s("(","#$","patientHasHadIRDoseGreaterThanHalfOfERDose","PAT",")","means","that","PAT","has","been","a","chronic","user","of","immediate","release","(","IR",")","opioids","for","some","period","of","time",",","during","which","their","corrected","dose","of","IR","opioids","was","greater","than","50","%","of","their","corrected","dose","of","extended","release","opioids","."),4956796). assertion_content_comment('patientHasHistory',s("Relates","a","patient","to","a","\"","history","\"","node","that","may","contain","various","nodes","used","to","specify","various","boolean","checks","to","see","whether","the","patient","had","a","history","of","certain","types","of","conditions","or","activities",".","A","typical","way","in","which","this","might","be","used","is","is",":","PATIENT","has","the","history","HISTORY",",","HISTORY","is","associated","with","a","#$","FamilyHistoryOfCoronaryArteryDisease","node","which","has","the","boolean","value","for","#$","familyHistoryOfDiseaseStatus","#$","True","."),3148113). assertion_content_comment('patientHasICD9CodesSet',s("(","#$","patientHasICD9Codes-Set","PATIENT","SET",")","means","that","PATIENT","has","been","diagnosed","with","conditions","corresponding","to","the","ICD-9","codes","in","the","set","SET","."),4907012). assertion_content_comment('patientHasInterleavedHICLsInChronicUseOfReleaseClass',s("(","#$","patientHasInterleavedHICLsInChronicUseOfReleaseClass","PATIENT","CLASS",")","means","that","PATIENT",",","during","a","chronic","use","of","drugs","in","the","release","class","CLASS",",","uses","at","least","two","pharmaceuticals","in","that","class","with","different","HICL","codes",",","and","they","do","not","just","switch","from","one","HICL","to","another","(","rather","they","use","one","HICL",",","\"","HICL-1","\"",",","then","another","HICL",",","\"","HICL-2","\"",",","and","then","another","HICL",",","\"","HICL-3","\"",":","HICL-1","and","HICL-3","may","or","may","not","be","different","from","each","other",",","but","both","are","different","form","HICL-2.",")"),4953768). assertion_content_comment('patientHasInterleavedNarcoticClaimsToDifferentGroupIDs',s("(","#$","patientHasInterleavedNarcoticClaimsToDifferentGroupIDs","PAT","CLAIM1","CLAIM2","CLAIM3",")","means","that","PAT","has","CLAIM1","and","CLAIM3","for","narcotics","on","one","group","ID",",","and","CLAIM2","on","another","group","ID",",","where","CLAIM2","is","processed","between","CLAIM1","and","CLAIM3","."),4941482). assertion_content_comment('patientHasMoreThanOneHICLInChronicUseOfReleaseClass',s("(","#$","patientHasMoreThanOneHICLInChronicUseOfReleaseClass","PATIENT","CLASS",")","means","that","PATIENT",",","during","a","chronic","use","of","drugs","in","the","release","class","CLASS",",","uses","at","least","two","pharmaceuticals","in","that","class","with","different","HICL","codes","."),4953164). assertion_content_comment('patientHasMultipleCoverages',s("(","#$","patientHasMultipleCoverages","PAT",")","means","that","PAT","has","used","more","than","one","benefit","to","accumulate","medication","."),4895409). assertion_content_comment('patientHasNarcoticClaimWithCustodianWithPrescriptionForPPTWithStatus',s("","(","patientHasNarcoticClaimWithCustodianWithPrescriptionForPPTWithStatus","PATIENT","PPT-TYPE","STATUS",")","","means","that","at","some","point","in","the","history","of","","PATIENT","",",","the","patient","of","the","claim","has","a","both","a","claim","for","an","opioid","(","an","instance","of","#$","CycRxOpioidType",")","and","a","custodian","with","another","claim","that","has","the","status","","STATUS","","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","a","#$","PharmacyFormalProductType","that","is","an","instance","of","","PPT-TYPE",""),4954654). assertion_content_comment('patientHasNarcoticClaimWithCustodianWithPrescriptionWithStatusForGC3',s("","(","patientHasNarcoticClaimWithCustodianWithPrescriptionWithStatusForGC3","PATIENT","CODE","STATUS",")","","means","that","at","some","point","in","the","history","of","","PATIENT","",",","","PATIENT","","has","a","both","a","claim","for","an","opioid","(","GC3","code","\"","H3A","\"",",","\"","B4D","\"",",","\"","H3C","\"",",","\"","H3N","\"",",","\"","B4Q","\"",",","\"","B6I","\"",",","\"","B3Q","\"","or","\"","H3W","\"",")","and","a","custodian","with","another","claim","that","has","the","status","","STATUS","","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","the","#$","PharmacyFormalProductType","that","has","the","GC3","code","","CODE",""),4931836). assertion_content_comment('patientHasNarcoticClaimWithDependentWithPrescriptionForPPTWithStatus',s("","(","patientHasNarcoticClaimWithDependentWithPrescriptionForPPTWithStatus","PATIENT","PPT-TYPE","STATUS",")","","means","that","at","some","point","in","the","history","of","","PATIENT","",",","","PATIENT","","has","a","both","a","claim","for","an","opioid","(","an","instance","of","#$","CycRxOpioidType",")","and","a","dependent","with","another","claim","that","has","the","status","","STATUS","","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","a","#$","PharmacyFormalProductType","that","is","an","instance","of","","PPT-TYPE",""),4954040). assertion_content_comment('patientHasNarcoticClaimWithDependentWithPrescriptionWithStatusForGC3',s("","(","patientHasNarcoticClaimWithDependentWithPrescriptionWithStatusForGC3","PATIENT","CODE","STATUS",")","","means","that","at","some","point","in","the","history","of","","PATIENT","",",","","PATIENT","","has","a","both","a","claim","for","an","opioid","(","GC3","code","\"","H3A","\"",",","\"","B4D","\"",",","\"","H3C","\"",",","\"","H3N","\"",",","\"","B4Q","\"",",","\"","B6I","\"",",","\"","B3Q","\"","or","\"","H3W","\"",")","and","a","dependent","with","another","claim","that","has","the","status","","STATUS","","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","the","#$","PharmacyFormalProductType","that","has","the","GC3","code","","CODE",""),4931837). assertion_content_comment('patientHasNarcoticClaimWithPrescriptionForPPTWithStatus',s("(","#$","patientHasNarcoticClaimWithPrescriptionForPPTWithStatus","PATIENT","PPT-TYPE","STATUS",")","means","that","at","some","point","in","the","history","of","PATIENT",",","PATIENT","has","a","both","a","claim","for","an","opioid","(","instance","of","#$","CycRxOpioidType",")","and","another","claim","that","has","the","status","STATUS","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","a","#$","PharmacyFormalProductType","that","is","an","instance","of","PPT-TYPE","."),4953675). assertion_content_comment('patientHasNarcoticClaimWithPrescriptionWithStatusForGC3',s("(","#$","patientHasNarcoticClaimWithPrescriptionWithStatusForGC3","PATIENT","CODE","STATUS",")","means","that","at","some","point","in","the","history","of","PATIENT",",","PATIENT","has","a","both","a","claim","for","an","opioid","(","GC3","code","\"","H3A","\"",",","\"","B4D","\"",",","\"","H3C","\"",",","\"","H3N","\"",",","\"","B4Q","\"",",","\"","B6I","\"",",","\"","B3Q","\"","or","\"","H3W","\"",")","and","another","claim","that","has","the","status","STATUS","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","the","#$","PharmacyFormalProductType","that","has","the","GC3","code","CODE","."),4894714). assertion_content_comment('patientHasNarcoticClaimWithSpouseWithPrescriptionForPPTWithStatus',s("","(","patientHasNarcoticClaimWithSpouseWithPrescriptionForPPTWithStatus","PATIENT","PPT-TYPE","STATUS",")","","means","that","at","some","point","in","the","history","of","","PATIENT","",",","","PATIENT","","has","a","both","a","claim","for","an","opioid","(","instance","of","#$","CycRxOpioidType",")","and","a","spouse","with","another","claim","claim","that","has","the","status","","STATUS","","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","a","#$","PharmacyFormalProductType","that","is","an","instance","of","","PPT-TYPE",""),4953688). assertion_content_comment('patientHasNarcoticClaimWithSpouseWithPrescriptionWithStatusForGC3',s("","(","patientHasNarcoticClaimWithSpouseWithPrescriptionWithStatusForGC3","PATIENT","CODE","STATUS",")","","means","that","at","some","point","in","the","history","of","","PATIENT","",",","","PATIENT","","has","a","both","a","claim","for","an","opioid","(","GC3","code","\"","H3A","\"",",","\"","B4D","\"",",","\"","H3C","\"",",","\"","H3N","\"",",","\"","B4Q","\"",",","\"","B6I","\"",",","\"","B3Q","\"","or","\"","H3W","\"",")","and","a","spouse","with","another","claim","claim","that","has","the","status","","STATUS","","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","the","#$","PharmacyFormalProductType","that","has","the","GC3","code","","CODE",""),4931030). assertion_content_comment('patientHasPharmaceuticalClaimsAll',s("(","#$","patientHasPharmaceuticalClaims-All","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","pharmaceutical","claims","made","by","PATIENT","."),4992381). assertion_content_comment('patientHasPharmaceuticalClaimsDispensed',s("(","#$","patientHasPharmaceuticalClaims-Dispensed","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","dispensed","pharmaceutical","claims","made","by","PATIENT","."),4992382). assertion_content_comment('patientHasPharmaceuticalClaimsUndispensednarcotic',s("(","#$","patientHasPharmaceuticalClaims-UndispensedNarcotic","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","undispensed","pharmaceutical","claims","made","by","PATIENT","."),4992402). assertion_content_comment('patientHasPharmaceuticalClaimsUndispensed',s("(","#$","patientHasPharmaceuticalClaims-Undispensed","PATIENT","SET-OF-PROFILE-LISTS",")","means","SET-OF-PROFILE-LISTS","contains","claim","information","for","all","undispensed","pharmaceutical","claims","made","by","PATIENT","."),4992403). assertion_content_comment('patientHasPrescriberTypeForOpioidClaim',s("(","#$","patientHasPrescriberTypeForOpioidClaim","PATIENT","DOC-TYPE",")","means","that","PATIENT","has","filed","a","claim","for","a","pharmaceutical","from","a","prescriber","of","type","DOC-TYPE","(","an","instance","of","#$","MedicalSpecialistType",")"),4973282). assertion_content_comment('patientHasPrescriptionWithStatusForDrugWithGC3',s("(","#$","patientHasPrescriptionWithStatusForDrugWithGC3","CLAIM","PATIENT","DRUG","GC3CODE","OTHER-CLAIM","STATUS",")","means","that","on","the","date","of","CLAIM","(","see","#$","claimProcessedOnDate",")",",","PATIENT","has","a","prior","claim","OTHER-CLAIM","with","status","STATUS","(","an","instance","of","#$","MedicalPrescriptionTypeByActiveStatus",")","for","the","#$","PharmacyFormalProductType","DRUG",",","which","is","a","drug","that","has","the","GC3","code","GC3CODE",".","Generally",",","having","an","active","prescription","means","that","OTHER-CLAIM","was","a","prescription","for","DRUG","that","was","filled","for","PATIENT","within","the","3","months","prior","to","DATE",",","whereas","having","an","inactive","prescription","means","that","OTHER-CLAIM","was","a","prescription","for","DRUG","was","filled","for","PATIENT","more","than","3","months","prior","to","DATE","no","further","prescription","for","DRUG","was","filled","for","PATIENT","within","the","last","3","months","."),4890392). assertion_content_comment('patientHasProviderWithSpecialtyForOpioidClaim',s("(","#$","patientHasProviderWithSpecialtyForOpioidClaim","PATIENT","SPECIALTY-TYPE",")","means","that","PATIENT","has","filed","a","claim","for","a","pharmaceutical","from","a","prescriber","of","type","SPECIALTY-TYPE","(","an","instance","of","#$","FieldOfStudy",")"),4973771). assertion_content_comment('patientHasSequentialClaimAndDrugProfilesForHICLAndReleaseType',s("(","#$","patientHasSequentialClaimAndDrugProfilesForHICLAndReleaseType","PATIENT","HICL","RELEASE","LIST-OF-PROFILE-LISTS",")","means","that","LIST-OF-PROFILE-LISTS","contains","claim","information","for","all","opioid","claims","made","by","PATIENT","for","a","single","pharmaceutical","agent","(","with","HICL","code",")","having","a","release","profile","of","RELEASE",",","irrespective","of","strength",",","dosage","form","or","other","properties",".","Elements","of","LIST-OF-PROFILE-LISTS","are","in","this","format",":","(","CLAIM","DATE","DAYS-SUPPLY","FILL-QTY","DRUG","HICL","MORPHINE-EQUIV-DOSE",")"),4961796). assertion_content_comment('patientHasSequentialClaimAndDrugProfilesForHICLRouteAndDosageType',s("(","#$","patientHasSequentialClaimAndDrugProfilesForHICLRouteAndDosageType","PATIENT","HICL","ROUTE","DOSAGE","LIST-OF-PROFILE-LISTS",")","means","that","LIST-OF-PROFILE-LISTS","contains","claim","information","for","all","opioid","claims","made","by","PATIENT","for","a","single","pharmaceutical","agent","(","with","HICL","code",")","having","an","administration","route","of","ROUTE","and","a","dosage","form","of","DOSAGE",",","irrespective","of","strength","or","other","properties",".","Elements","of","LIST-OF-PROFILE-LISTS","are","in","this","format",":","(","CLAIM","DATE","DAYS-SUPPLY","FILL-QTY","DRUG","HICL","ROUTE","DOSAGE","MORPHINE-EQUIV-DOSE",")"),4976941). assertion_content_comment('patientHasSequentialClaimAndDrugProfilesForNarcoticWithReleaseProfileBetweendates',s("(","#$","patientHasSequentialClaimAndDrugProfilesForNarcoticWithReleaseProfile-BetweenDates","PATIENT","NARCO-RELEASE-PROFILE","LIST-OF-PROFILE-LISTS","D1","D2",")","means","that","between","the","dates","D1","and","D2",",","PATIENT","has","had","claims","for","drugs","with","NARCO-RELEASE-PROFILE","on","dates","that","are","mentioned","in","\"","drug-profile","\"","lists","of","the","form","(","#$","TheList","CLAIM","DATE","DAYS-SUPPLY","DRUG","LABEL-TEXT","HICL","ADMIN","DOSAGE-FORM","STRENGTH",")",",","which","are","also","in","the","reverse-historical","sequence","of","the","elements","in","the","list","LIST","."),4949237). assertion_content_comment('patientHasSequentialClaimAndDrugProfilesForNarcoticWithReleaseProfile',s("(","#$","patientHasSequentialClaimAndDrugProfilesForNarcoticWithReleaseProfile","PATIENT","NARCO-RELEASE-PROFILE","LIST-OF-PROFILE-LISTS",")","means","that","PATIENT","has","had","claims","for","drugs","with","NARCO-RELEASE-PROFILE","on","dates","that","are","mentioned","in","\"","drug-profile","\"","lists","of","the","form","(","#$","TheList","CLAIM","DATE","DAYS-SUPPLY","DRUG","LABEL-TEXT","HICL","ADMIN","DOSAGE-FORM","STRENGTH",")",",","which","are","also","in","the","reverse-historical","sequence","of","the","elements","in","the","list","LIST","."),4947392). 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assertion_content_comment('patientHasSequentialClaimAndDrugProfilesForPharmaceuticalTypeAtStrength',s("(","#$","patientHasSequentialClaimAndDrugProfilesForPharmaceuticalType","PATIENT","DRUG","STRENGTH","LIST-OF-PROFILE-LISTS",")","means","that","PATIENT","has","had","claims","for","drug","DRUG","at","STRENGTH","on","dates","that","are","mentioned","in","\"","drug-profile","\"","lists","of","the","form","(","#$","TheList","CLAIM","DATE","DAYS-SUPPLY","DRUG","LABEL-TEXT","HICL","ADMIN","DOSAGE-FORM","STRENGTH",")",",","which","are","also","in","the","reverse-historical","sequence","of","the","elements","in","the","list","LIST","."),4949399). 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assertion_content_comment('patientHasSequentialClaimAndDrugProfilesForReleaseType',s("(","#$","patientHasSequentialClaimAndDrugProfilesForHICLAndReleaseType","PATIENT","RELEASE","LIST-OF-PROFILE-LISTS",")","means","that","LIST-OF-PROFILE-LISTS","contains","claim","information","for","all","claims","made","by","PATIENT","for","opioids","having","a","release","profile","of","RELEASE",",","irrespective","of","which","opioid","ingredient","they","contain",".","Elements","of","LIST-OF-PROFILE-LISTS","are","in","this","format",":","(","CLAIM","DATE","DAYS-SUPPLY","FILL-QTY","DRUG","HICL","MORPHINE-EQUIV-DOSE",")"),4963946). assertion_content_comment('patientHasSequentialNarcoticAntitussiveClaimAndDrugProfiles',s("(","#$","patientHasSequentialNarcoticAntitussiveClaimAndDrugProfiles","PATIENT","LIST-OF-PROFILE-LISTS",")","means","that","LIST-OF-PROFILE-LISTS","contains","claim","information","representing","all","claims","made","by","PATIENT","for","drugs","in","any","of","the","#$","NarcoticAntitussive","classes","(","i.e.",",","combination","drugs","whose","therapeutic","class","TC","is","such","that","(","#$","activeIngredientsOfType","TC","#$","NarcoticAntitussive",")","Elements","of","LIST-OF-PROFILE-LISTS","are","in","this","format",":","(","CLAIM","DATE","DAYS-SUPPLY","FILL-QTY","DRUG",")"),4968553). 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assertion_content_comment('patientHasTakenOver120MgOralMorhpineEquivalentForAtLeast90DaysAllcombined',s("(","#$","patientHasTakenOver120MgOralMorhpineEquivalentForAtLeast90Days-AllCombined","PATIENT",")","means","during","some","time","period","or","90","days","or","more",",","PATIENT","took","a","daily","dose","of","all","opioids","combined","that","exceeds","120","oral-morphine-equivalent","milligrams","per","day","."),4968021). assertion_content_comment('patientHasTakenOver120MgOralMorphineEquivalentForAtLeast90DaysOneironeer',s("(","#$","patientHasTakenOver120MgOralMorphineEquivalentForAtLeast90Days-OneIROneER","PATIENT",")","means","that","there","is","some","period","of","time","90","days","or","longer","during","which","PATIENT","is","taking","a","daily","dose","of","120","oral-morphine-equivalent","milligrams","per","day","of","opioids","that","include","only","one","immediate","release","agent","and","one","extended","release","agent","."),4964063). 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assertion_content_comment('patientHasTakenOver120MgOralMorphineEquivalentOfSingleIRAgentForAtLeast90Days',s("(","#$","patientHasTakenOver120MgOralMorphineEquivalentOfSingleIRAgentForAtLeast90Days","PATIENT",")","means","that","there","is","some","period","of","time","90","days","or","longer","during","which","PATIENT","is","taking","a","daily","dose","of","a","single","immediate","release","agent","(","drugs","that","share","a","HICL","code",")","that","exceeds","120","oral-morphine-equivalent","milligrams","per","day","."),4963963). assertion_content_comment('patientHasUnwarrantedNarcoticClaimDueToYouth',s("(","#$","patientHasUnwarrantedNarcoticClaimDueToYouth","PATIENT",")","means","that","on","the","date","of","a","claim","for","narcotics","for","PATIENT",",","PATIENT","was","considered","too","young","."),4895018). assertion_content_comment('patientInCareEvent',s("#$","ActorSlot","that","relates","an","instance","of","a","#$","MedicalCareEvent","to","the","#$","MedicalPatient","in","that","event","."),1077716). assertion_content_comment('patientMinimalYearAgeDuringMedicalEvent',s("","(","#$","patientMinimalYearAgeDuringMedicalEvent","PAT","EVT","TIME-QUANTITY",")","","means","that","the","#$","MedicalPatient","","PAT","","is","at","least","","TIME-QUANTITY","","old","at","the","time","of","the","start","of","the","event","","EVT","","Typically",",","the","units","are","expressed","in","#$","YearsDuration","."),3102613). assertion_content_comment('patientOfClaimDispensedopiate',s("(","#$","patientOfClaim-DispensedOpiate","CLAIM","PATIENT",")","means","that","the","claim","filed","in","the","#$","FilingAHealthInsuranceClaim",",","CLAIM",",","is","a","dispensed","claim","filed","for","an","opiate","provided","to","PATIENT","."),4971090). 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assertion_content_comment('patientStartedOnMedTypeStatusWRTEvent',s("(","#$","patientStartedOnMedTypeStatusWRTEvent","OP","MED-TYPE","?","STATUS",")","means","that","the","MED-TYPE","has","STATUS","true","if","the","patient","in","OP","started","receiving","medication","of","type","MED-TYPE","during","the","#$","MedicalCareEvent","OP","and","FALSE","if","they","received","meds","but","not","of","MED-TYPE","."),3351663). assertion_content_comment('patientTakingOver120MgOralMorhpineEquivalentBetweenDatesAllcombined',s("(","#$","patientTakingOver120MgOralMorhpineEquivalentBetweenDates-AllCombined","PATIENT","START-DATE","END-DATE",")","means","that","for","the","period","of","time","between","START-DATE","and","END-DATE",",","PATIENT","is","taking","a","daily","dose","of","all","opioids","combined","that","exceeds","120","oral-morphine-equivalent","milligrams","per","day","."),4960586). assertion_content_comment('patientTreatedHasHispanicEthnicity',s("A","#$","CCFHelperPredicate",".","(","#$","patientTreatedHasHispanicEthnicity","INDEX","True",")","means","that","INDEX","is","an","event","in","which","the","patient","treated","is","of","hispanic","ethnicity","."),3658062). assertion_content_comment('patientTreated',s("(","#$","patientTreated","TREATMENT","PATIENT",")","means","that","PATIENT",",","an","instance","of","#$","Animal",",","is","an","instance","of","#$","MedicalPatient","during","TREATMENT","(","an","instance","of","#$","MedicalTreatmentEvent",")","and","is","treated","by","that","TREATMENT","."),1078578). assertion_content_comment('patientWithERIrratiobetweendates',s("(","#$","patientWithER-IRRatioBetweenDates","PATIENT","RATIO","DATE1","DATE2",")","means","that","between","DATE1","and","DATE2",",","the","ratio","of","PATIENT","'","s","dosing","rate","with","extended","release","narcotics","to","their","dosing","rate","with","immediate","release","narcotics","is","RATIO","."),4948362). assertion_content_comment('patientWithoutClaimOfTypeWithinWindowBeforeOrAfterDate',s("(","#$","patientWithoutClaimOfTypeWithinWindowBeforeOrAfterDate","PATIENT","CLAIM-TYPE","WINDOW","DATE",")","means","that","in","the","period","of","time","starting","WINDOW","amount","of","time","before","DATE",",","and","ending","WINDOW","amount","of","time","after","DATE",",","PATIENT","had","no","claims","of","type","CLAIM-TYPE","."),4924178). assertion_content_comment('patientZipCodeAssociatedWithClaim',s("(","#$","patientZipCodeAssociatedWithClaim","CLAIM","ZIP-CODE",")","means","that","ZIP-CODE","is","the","ZIP","code","of","the","provider","location","associated","with","CLAIM","."),4988221). assertion_content_comment('patternTypeOriginatesFromResistLayerOfType',s("The","corresponding","predicate","(","#$","functionCorrespondingPredicate-Canonical",")","of","#$","EtchedWaferPatternTypeByReferenceLayerTypeFn",".","Where","LAYER-TYPE","is","a","collection","instance","of","#$","PhotoresistReferenceLayerType",",","(","#$","patternTypeOriginatesFromResistLayerOfType","LAYER-TYPE","ETCH-TYPE",")","means","that","ETCH-TYPE","is","the","collection","of","all","#$","EtchedWaferPatterns","deriving","from","#$","PhotolithographyProcess-SingleIteration","instances","wherein","the","#$","ResistLayer","involved","was","an","instance","of","LAYER-TYPE","."),3602926). 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assertion_content_comment('pavedWithType',s("(","#$","pavedWithType","THING","PAVING-MATERIAL",")","means","that","THING","is","paved","with","instances","of","PAVING-MATERIAL",",","and","is","therefore","an","instance","of","#$","Paved","."),5022457). assertion_content_comment('payer',s("","(","#$","payer","MONEY-TRANSFER","PAYER",")","","means","that","","MONEY-TRANSFER","","is","an","instance","of","#$","MoneyTransfer","in","which","","PAYER","","is","an","agent","which","provides","(","some","of",")","the","money","."),1160151). assertion_content_comment('payingWithObjectsOfType',s("A","predicate","corresponding","to","the","function","#$","PayingWithObjectsOfTypeFn",".","","(","#$","payingWithObjectsOfType","X","(","#$","PayingWithObjectsOfTypeFn","X",")",")","","will","always","be","true","for","","X","","meeting","the","relevant","arg","constraints","."),3067713). 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assertion_content_comment('paymentDueForAccount',s("The","agent","ARG1","owes","to","(","is","obliged","to","pay","toward",")","account","ARG2","the","amount","ARG4","by","the","date","ARG3",".","ARG3","is","the","payment","due","date",".","This","says","nothing","about","whether","the","payment","is","actually","made",".","It","is","just","a","way","of","stating","that","there","is","an","obligation","to","pay","."),1094711). assertion_content_comment('paymentDueForRequest',s("The","money","which","would","be","due","from","the","buyer","if","the","requested","purchase","transaction","was","completed","."),1060776). assertion_content_comment('paymentInForType',s("Payments","are","made","to","ARG1","for","events","of","type","ARG2","during","time","ARG3","of","total","ARG4","."),1056546). assertion_content_comment('paymentIn',s("Agent","ARG1","is","paid","(","for","a","debt","incurred","in","event","ARG2",")","at","time","ARG3","the","amount","of","money","ARG4","."),1055864). assertion_content_comment('paymentModeForPurchase',s("A","predicate","relating","types","of","things","that","people","pay","to","use","or","buy","and","common","payment","methods","for","using","or","buying","them",".","(","#$","paymentModeForPurchase","THINGTYPE","PAYMENTTYPE",")","means","that","PAYMENTTYPE","is","a","common","way","to","purchase","or","pay","to","use","an","instance","of","THINGTYPE","."),1046967). assertion_content_comment('paymentObligationValue',s("(","#$","paymentObligationValue","OBLIGATION","MONEY",")","means","that","MONEY","is","the","instance","of","#$","MonetaryValue","that","is","the","value","of","the","payment","obligation","(","see","#$","PaymentObligation",")","OBLIGATION",".","For","example",",","(","#$","paymentObligationValue","DryCleaningBill001","(","#$","Dollar-UnitedStates","3.5",")",")","means","that","the","value","of","drycleaning","bill","001","is","$","3.50","."),1730445). assertion_content_comment('paymentOutForType',s("ARG1","makes","payments","for","events","of","type","ARG2","during","time","ARG3","of","total","ARG4","."),1055633). assertion_content_comment('paymentOut',s("Agent","ARG1","pays","(","for","a","debt","incurred","in","event","ARG2",")","at","time","ARG3","the","amount","of","money","ARG4","."),1056088). assertion_content_comment('paymentScheduleForAgreement',s("(","#$","paymentScheduleForAgreement","SCHEDULE","AGREEMENT",")","says","that","SCHEDULE","is","a","schedule","for","making","payments","for","monies","owed","as","part","of","the","agreement","AGREEMENT","."),1674845). assertion_content_comment('paymentThroughActionType',s("A","predicate","corresponding","to","the","function","#$","PaymentThroughActionTypeFn",".","","(","#$","paymentThroughActionType","X","(","#$","PaymentThroughActionTypeFn","X",")",")","","will","always","be","true","for","","X","","meeting","the","relevant","arg","constraints","."),3069510). assertion_content_comment('payorCommercialInsuranceForHospitalVisit',s("A","#$","CCFHelperPredicate",".","(","#$","payorCommercialInsuranceForHospitalVisit","INDEX","#$","True",")","means","that","commercial","health","insurance","is","a","payor","for","the","hospital","visit","during","which","INDEX","takes","place","."),3655929). assertion_content_comment('payorGovIHSForHospitalVisit',s("A","#$","CCFHelperPredicate",".","(","#$","payorGovIHSForHospitalVisit","INDEX","#$","True",")","means","that","IHS","is","a","payor","for","the","hospital","visit","during","which","INDEX","takes","place","."),3655930). assertion_content_comment('payorGovMedicaidForHospitalVisit',s("A","#$","CCFHelperPredicate",".","(","#$","payorGovMedicaidForHospitalVisit","INDEX","#$","True",")","means","that","Medicaid","is","a","payor","for","the","hospital","visit","during","which","INDEX","takes","place","."),3655931). assertion_content_comment('payorGovMedicareForHospitalVisit',s("A","#$","CCFHelperPredicate",".","(","#$","payorGovMedicareForHospitalVisit","INDEX","#$","True",")","means","that","Medicare","is","a","payor","for","the","hospital","visit","during","which","INDEX","takes","place","."),3655932). assertion_content_comment('payorGovMilForHospitalVisit',s("A","#$","CCFHelperPredicate",".","(","#$","payorGovMilForHospitalVisit","INDEX","#$","True",")","means","that","U.S",".","military","insurance","is","a","payor","for","the","hospital","visit","during","which","INDEX","takes","place","."),3655933). assertion_content_comment('payorGovStateForHospitalVisit',s("A","#$","CCFHelperPredicate",".","(","#$","payorGovStateForHospitalVisit","INDEX","#$","True",")","means","that","state","health","insurance","is","a","payor","for","the","hospital","visit","during","which","INDEX","takes","place","."),3655934). assertion_content_comment('payorNonUSForHospitalVisit',s("A","#$","CCFHelperPredicate",".","(","#$","payorNonUSForHospitalVisit","INDEX","#$","True",")","means","that","non-U.S",".","(","i.e.",",","foreign",")","insurance","is","a","payor","for","the","hospital","visit","during","which","INDEX","takes","place","."),3655935). assertion_content_comment('payorSelfForHospitalVisit',s("A","#$","CCFHelperPredicate",".","(","#$","payorSelfForHospitalVisit","INDEX","#$","True",")","means","that","a","payor","for","the","hospital","visit","during","which","INDEX","takes","place","is","the","patient","treated","."),3655928). assertion_content_comment('pays',s("A","'","non-Davidsonian","'","#$","EventPredicate",".","#$","pays","is","the","relation","that","holds","between","the","#$","buyingAgent","in","a","#$","MoneyTransfer","and","the","#$","objectTendered","in","that","same","transfer","event",",","at","least","while","the","event","is","taking","place","."),878101). assertion_content_comment('pays',s("As","of","01/20/02","there","is","an","issue","attaching","to","the","concept","of","payment","that","remains","to","be","resolved",".","Specifically",",","#$","TenderObject","is","probably","too","restrictive","an","argument","constraint","for","this","and","for","related","predicates","such","as","#$","objectTendered",".","That","is","because","there","are","'","barter-like","'","cases","of","payment","where","what","is","paid","is","not","a","recognized","#$","TenderObject",",","at","least","by","Western","standards",".","What","is","probably","indicated","is","the","creation","of","a","direct","generalization","of","#$","objectTendered",",","and","by","extension",",","of","this","predicate","."),878104). assertion_content_comment('pays',s("The","#$","SocialBeing","doing","the","paying","in","a","#$","MoneyTransfer","may","be","only","a","proxy","for","the","agent","who","is","doing","the","buying","in","a","#$","MonetaryExchangeOfUserRights","that","is","of","broader","scope","."),878115). assertion_content_comment('pays',s("Where","PAYER","is","the","#$","buyingAgent","in","a","#$","MoneyTransfer","and","PAID","is","the","#$","objectOfTendered",",","it","is","true","that","(","#$","pays","PAYER","PAID",")","for","the","whole","duration","of","the","exchange",".","It","is","probably","not","the","case","that","the","assertion","continues","to","hold","for","all","time","to","come","after","the","exchange","in","question","is","over",",","but","this","remains","to","be","resolved","."),878102). assertion_content_comment('pays',s("Where","PAYER","is","the","#$","buyingAgent","in","a","#$","MoneyTransfer","and","PAID","is","the","#$","objectTendered",",","it","is","true","that","(","#$","pays","PAYER","PAID",")","for","the","whole","duration","of","the","exchange",".","It","is","probably","not","the","case","that","the","assertion","continues","to","hold","for","all","time","to","come","after","the","exchange","in","question","is","over",",","but","this","remains","to","be","resolved","."),878112). assertion_content_comment('pciDelayReason',s("A","#$","CCFHelperPredicate",".","(","#$","pciDelayReason","INDEX","REASON",")","means","that","INDEX","is","a","PCI","with","the","delay","reason","REASON","."),3657830). assertion_content_comment('pciHasAdmitSource',s("A","#$","CCFHelperPredicate",".","(","#$","pciHasAdmitSource","INDEX","SOURCE",")","means","that","INDEX","is","a","PCI","with","the","admit","source","."),3657884). assertion_content_comment('pciHasCardiacStressIschemiarisk',s("A","#$","CCFHelperPredicate",".","(","#$","pciHasPriorStressTestWithCMR-IschemiaRisk","INDEX","RESULT",")","means","that","INDEX","is","a","PCI","with","a","prior","cardiac","stress","showing","ischemia","risk","of","RESULT","(","per","the","CathPCIv4","definition",")"),3657184). assertion_content_comment('pciHasCardiomyopathyIndication',s("A","#$","CCFHelperPredicate",".","(","#$","pciHasCardiomyopathyIndication","PCI","#$","True",")","means","that","PCI","is","a","percutaneous","coronary","intervention","with","a","cardiomyopathy","indication","(","per","the","CathPCIv4","definition",")"),3657891). 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